TY - CPAPER T1 - A Us Fda Perspective on Safety Biomarkers and the Qualification Process T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313115003; 6137491 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Walton, M Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Bioindicators KW - FDA KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313115003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=A+Us+Fda+Perspective+on+Safety+Biomarkers+and+the+Qualification+Process&rft.au=Walton%2C+M&rft.aulast=Walton&rft.aufirst=M&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Vitro/in Silico/Exploratory Assessment of Pharmaceuticals T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313114770; 6137093 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Jacobs, A Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313114770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=In+Vitro%2Fin+Silico%2FExploratory+Assessment+of+Pharmaceuticals&rft.au=Jacobs%2C+A&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Multilaboratory Assessment of Best Practices for Measuring Injuryassociated Micrornas in Biofluids Using a Model of Isoproterenolinduced Myocardial Injury in Rats T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313106962; 6137310 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Thompson, K AU - Bauer, Y AU - Chen, T AU - Couttet, P AU - Ellinger-Ziegelbauer, H AU - Kanki, M AU - Leonard, J AU - Nassirpour, R AU - Searfoss, G AU - Sharapova, T AU - Kelsall, J AU - Uchiyama, H AU - Yuen, P AU - Spire, C AU - O'Lone, R Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Best practices KW - Injuries KW - Rats KW - miRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313106962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Multilaboratory+Assessment+of+Best+Practices+for+Measuring+Injuryassociated+Micrornas+in+Biofluids+Using+a+Model+of+Isoproterenolinduced+Myocardial+Injury+in+Rats&rft.au=Thompson%2C+K%3BBauer%2C+Y%3BChen%2C+T%3BCouttet%2C+P%3BEllinger-Ziegelbauer%2C+H%3BKanki%2C+M%3BLeonard%2C+J%3BNassirpour%2C+R%3BSearfoss%2C+G%3BSharapova%2C+T%3BKelsall%2C+J%3BUchiyama%2C+H%3BYuen%2C+P%3BSpire%2C+C%3BO%27Lone%2C+R&rft.aulast=Thompson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epigenetic and Mirna Dysregulation in Liver Nongenotoxic and Genotoxic Tumorigenesis T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313098189; 6137362 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Kutanzi, K AU - Melnyk, S AU - Koturbash, I AU - Pogribny, I Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Genotoxicity KW - Liver KW - miRNA KW - Tumorigenesis KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313098189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Epigenetic+and+Mirna+Dysregulation+in+Liver+Nongenotoxic+and+Genotoxic+Tumorigenesis&rft.au=Kutanzi%2C+K%3BMelnyk%2C+S%3BKoturbash%2C+I%3BPogribny%2C+I&rft.aulast=Kutanzi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Use of Computational Toxicology Tools and Databases at the Fda, Office of Food Additive Safety T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313088570; 6137024 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Arvidson, K Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Food additives KW - Toxicology KW - FDA KW - Databases KW - Computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313088570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Regulatory+Use+of+Computational+Toxicology+Tools+and+Databases+at+the+Fda%2C+Office+of+Food+Additive+Safety&rft.au=Arvidson%2C+K&rft.aulast=Arvidson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspectives of Contemporary Issues in Ocular Toxicology T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313073678; 6137107 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Chambers, W Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313073678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Regulatory+Perspectives+of+Contemporary+Issues+in+Ocular+Toxicology&rft.au=Chambers%2C+W&rft.aulast=Chambers&rft.aufirst=W&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Recognition of Nanoparticles by Macrophages--from Principles to Consequences and Toxicity T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313032865; 6137117 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Shvedova, A Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Toxicity KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313032865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Recognition+of+Nanoparticles+by+Macrophages--from+Principles+to+Consequences+and+Toxicity&rft.au=Shvedova%2C+A&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Immunomodulation and Cancer: A Regulatory Perspective T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313025216; 6137042 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Mellon, D Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Cancer KW - Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313025216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Immunomodulation+and+Cancer%3A+A+Regulatory+Perspective&rft.au=Mellon%2C+D&rft.aulast=Mellon&rft.aufirst=D&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The effect of hepatitis C treatment and human immunodeficiency virus (HIV) co-infection on the disease burden of hepatitis C among injecting drug users in Amsterdam AN - 928988935; 4279043 AB - Aims The hepatitis C virus (HCV) disease burden among injecting drug users (IDUs) is determined by HCV incidence, the long latency period of HCV, competing mortality causes, presence of co-infection and HCV treatment uptake. We examined the effect of these factors and estimated the HCV disease burden in Amsterdam. Design A Markov model was developed, incorporating HCV and human immunodeficiency virus (HIV), and parameterized with data from the Amsterdam Cohort Studies, surveillance studies and literature. Setting IDU population of Amsterdam. Measurements HCV infection simulated from its acute phase to HCV-related liver disease (i.e. decompensated cirrhosis and hepatocellular carcinoma). Findings The HCV prevalence among IDUs in Amsterdam increased to approximately 80% in the 1980s. From 2011 to 2025, the HCV-related disease prevalence will accordingly rise by 36%, from 57 cases (95% range 33–94) to 78 (95% range 43–138), respectively. In total, 945 (95% range 617–1309) individuals will develop HCV-related liver disease. This burden would have been 33% higher in the absence of HIV, resulting in 1219 cases (95% range 796–1663). In Amsterdam, 25% of HIV-negative IDUs receive successful HCV treatment, reducing the cumulative disease burden by 14% to 810 (95% range 520–1120). Further reduction of 36% can be achieved by improving treatment, resulting in 603 cases (95% range 384–851). Conclusions The hepatitis C virus burden among injecting drug users in Amsterdam has been reduced by a high competing mortality rate, particularly caused by HIV infection, and to a smaller extent by hepatitis C virus treatment. Improved hepatitis C virus treatment is expected to contribute to reduce the future hepatitis C virus disease burden. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Coutinho, Roel AU - Prins, Maria AU - Matser, Amy AU - Urbanus, Anouk AU - Geskus, Ronald AU - Kretzschmar, Mirjam AU - Xiridou, Maria AU - Buster, Marcel AD - Amsterdam Public Health Service ; Academic Medical Centre ; Utrecht University ; National Institute of Public Health and the Environment, Netherlands Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 614 EP - 623 VL - 107 IS - 3 SN - 0965-2140, 0965-2140 KW - Sociology KW - Hepatitis KW - Medical care KW - AIDS KW - Liver KW - Medical treatment KW - Diseases KW - Netherlands KW - HIV KW - Illness KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/928988935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+effect+of+hepatitis+C+treatment+and+human+immunodeficiency+virus+%28HIV%29+co-infection+on+the+disease+burden+of+hepatitis+C+among+injecting+drug+users+in+Amsterdam&rft.au=Coutinho%2C+Roel%3BPrins%2C+Maria%3BMatser%2C+Amy%3BUrbanus%2C+Anouk%3BGeskus%2C+Ronald%3BKretzschmar%2C+Mirjam%3BXiridou%2C+Maria%3BBuster%2C+Marcel&rft.aulast=Coutinho&rft.aufirst=Roel&rft.date=2012-03-01&rft.volume=107&rft.issue=3&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2011.03654.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5810 3617 6220; 5703 3617 6220; 482 3617 6220; 7890 5792 10484; 7875 5775 13521; 3617 6220; 10449 5772; 7473 1678; 6220; 275 462 129 DO - http://dx.doi.org/10.1111/j.1360-0443.2011.03654.x ER - TY - JOUR T1 - Medicare managed care and primary care quality: examining racial/ethnic effects across states AN - 926885604; 16381256 AB - The study assesses the role of Medicare Advantage (MA) plans in providing quality primary care in comparison to FFS Medicare in three states, New York, California, Florida, across three racial ethnic groups. The performance is measured in terms of providing better quality primary care, as defined by lowering the risks of preventable hospital admissions. Using 2004 hospital discharge data (HCUP-SID) of Agency for Healthcare Research and Quality for three states, a multivariate cross sectional design is used with individual admission as the unit of analysis. The study found that MA plans were associated with lower preventable hospitalizations relative to marker admissions. The benefit also spilled over to different racial and ethnic subgroups and in some states, e.g. CA and FL, MA enrollment was associated with significantly lower odds of minority admissions than of white admissions. These results may indicate a potentially favorable role of MA plans in attenuating racial/ethnic inequalities in primary care in some states. JF - Health Care Management Science AU - Basu, Jayasree AD - Center for Primary care, Prevention, and Clinical Partnerships Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, 20850, USA, Jayasree.basu@ahrq.hhs.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 15 EP - 28 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 15 IS - 1 SN - 1386-9620, 1386-9620 KW - Risk Abstracts KW - Ethnic groups KW - Health care KW - Hospitals KW - USA, Florida KW - USA, New York KW - USA, California KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926885604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Regulatory+Perspective+on+Continuous+Manufacturing&rft.au=Chatterjee%2C+Sharmista&rft.aulast=Chatterjee&rft.aufirst=Sharmista&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Health care; Ethnic groups; Hospitals; USA, Florida; USA, California; USA, New York DO - http://dx.doi.org/10.1007/s10729-011-9176-5 ER - TY - JOUR T1 - Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus. AN - 922761235; 22348907 AB - Probiotic lactic acid bacteria (LAB) have been shown to alleviate inflammation, enhance the immunogenicity of rotavirus vaccines, or reduce the severity of rotavirus diarrhoea. Although the mechanisms are not clear, the differential Th1/Th2/Th3-driving capacities and modulating effects on cytokine production of different LAB strains may be the key. Our goal was to delineate the influence of combining two probiotic strains of Lactobacillus acidophilus and Lactobacillus reuteri on the development of cytokine responses in neonatal gnotobiotic pigs infected with human rotavirus (HRV). We demonstrated that HRV alone, or HRV plus LAB, but not LAB alone, initiated serum cytokine responses, as indicated by significantly higher concentrations of IFN-α, IFN-γ, IL-12, and IL-10 at postinoculation day (PID) 2 in the HRV only and LAB+HRV+ pigs compared to LAB only and LAB-HRV- pigs. Peak cytokine responses coincided with the peak of HRV replication. LAB further enhanced the Th1 and Th2 cytokine responses to HRV infection as indicated by significantly higher concentrations of IL-12, IFN-γ, IL-4 and IL-10 in the LAB+HRV+ pigs compared to the LAB-HRV+ pigs. The LAB+HRV+ pigs maintained relatively constant concentrations of TGF-β compared to the HRV only group which had a significant increase at PID 2 and decrease at PID 7, suggesting a regulatory role of LAB in maintaining gut homeostasis. At PID 28, cytokine secreting cell (CSC) responses, measured by ELISpot, showed increased Th1 (IL-12, IFN-γ) CSC numbers in the LAB+HRV+ and LAB-HRV+ groups compared to LAB only and LAB-HRV- pigs, with significantly increased IL-12 CSCs in spleen and PBMCs and IFN-γ CSCs in spleen of the LAB+HRV+ group. Thus, HRV infection alone, but not LAB alone was effective in inducing cytokine responses but LAB significantly enhanced both Th1 and Th2 cytokines in HRV-infected pigs. LAB may also help to maintain immunological homeostasis during HRV infection by regulating TGF-β production. JF - Beneficial microbes AU - Azevedo, M S P AU - Zhang, W AU - Wen, K AU - Gonzalez, A M AU - Saif, L J AU - Yousef, A E AU - Yuan, L AD - US Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA. Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 33 EP - 42 VL - 3 IS - 1 KW - Cytokines KW - 0 KW - Index Medicus KW - Th1 Cells -- immunology KW - Animals KW - Germ-Free Life KW - Probiotics -- administration & dosage KW - Diarrhea -- immunology KW - Enzyme-Linked Immunospot Assay KW - Diarrhea -- virology KW - Spleen -- immunology KW - Spleen -- virology KW - Th2 Cells -- immunology KW - Intestines -- microbiology KW - Intestines -- immunology KW - Swine -- microbiology KW - Rotavirus -- immunology KW - Lactobacillus reuteri -- immunology KW - Swine -- immunology KW - Lactobacillus acidophilus -- immunology KW - Rotavirus -- pathogenicity KW - Cytokines -- immunology KW - Swine -- virology KW - Rotavirus Infections -- immunology KW - Rotavirus Infections -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/922761235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Beneficial+microbes&rft.atitle=Lactobacillus+acidophilus+and+Lactobacillus+reuteri+modulate+cytokine+responses+in+gnotobiotic+pigs+infected+with+human+rotavirus.&rft.au=Azevedo%2C+M+S+P%3BZhang%2C+W%3BWen%2C+K%3BGonzalez%2C+A+M%3BSaif%2C+L+J%3BYousef%2C+A+E%3BYuan%2C+L&rft.aulast=Azevedo&rft.aufirst=M+S&rft.date=2012-03-01&rft.volume=3&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Beneficial+microbes&rft.issn=1876-2891&rft_id=info:doi/10.3920%2FBM2011.0041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-14 N1 - Date created - 2012-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nutr. 2000 Feb;130(2S Suppl):396S-402S [10721914] PLoS Comput Biol. 2011 Jul;7(7):e1002122 [21829337] Microbes Infect. 2001 Sep;3(11):947-54 [11564443] J Immunol. 2002 Jan 1;168(1):171-8 [11751960] Pediatrics. 2002 Apr;109(4):678-84 [11927715] Gut. 2002 May;50 Suppl 3:III54-9 [11953334] Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):147-60 [12072229] Pediatr Infect Dis J. 2002 May;21(5):411-6 [12150178] Curr Pharm Des. 2003;9(2):175-91 [12570667] Clin Diagn Lab Immunol. 2003 Nov;10(6):995-1001 [14607858] Clin Diagn Lab Immunol. 2004 Jan;11(1):12-20 [14715539] Clin Exp Immunol. 1990 Apr;80(1):49-55 [2157566] Br J Nutr. 1990 Jul;64(1):71-9 [2119224] Pediatrics. 1991 Jul;88(1):90-7 [1905394] J Immunol. 1993 May 1;150(9):3990-4000 [8386204] Gut. 1994 Jul;35(7):934-40 [8063221] J Virol. 1996 May;70(5):3075-83 [8627786] J Gen Virol. 1996 Jul;77 ( Pt 7):1431-41 [8757984] Acta Paediatr. 1997 May;86(5):460-5 [9183482] J Pediatr Gastroenterol Nutr. 1997 Nov;25(5):516-9 [9360205] Appl Microbiol. 1964 Jul;12:295-300 [14199016] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2880-5 [15710900] J Virol. 2006 Jan;80(1):372-82 [16352562] Clin Vaccine Immunol. 2006 Mar;13(3):365-75 [16522779] J Physiol Pharmacol. 2006 Nov;57 Suppl 9:13-21 [17242484] Clin Nutr. 2007 Aug;26(4):450-9 [17544549] Curr Opin Gastroenterol. 2007 Nov;23(6):679-92 [17906447] Int Immunol. 2007 Dec;19(12):1319-27 [17951600] Vet Immunol Immunopathol. 2008 Feb 15;121(3-4):222-31 [18006076] Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):175-81 [18023882] Vaccine. 2008 Jun 19;26(26):3322-31 [18456375] Vaccine. 2008 Jul 4;26(29-30):3655-61 [18524434] Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19474-9 [19047644] Am J Respir Crit Care Med. 2009 Feb 1;179(3):186-93 [19029003] Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):304-15 [19054578] Viral Immunol. 2010 Apr;23(2):135-49 [20373994] Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):267-75 [21489639] J Dairy Sci. 2001 Feb;84(2):319-31 [11233016] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3920/BM2011.0041 ER - TY - JOUR T1 - (Q)SAR modeling and safety assessment in regulatory review. AN - 922501343; 22258468 AB - The ability to predict clinical safety based on chemical structures is becoming an increasingly important part of regulatory decision making. (Quantitative) structure-activity relationship ((Q)SAR) models are currently used to evaluate late-arising safety concerns and possible nonclinical effects of a drug and its related compounds when adequate safety data are absent or equivocal. Regulatory use will likely increase with the standardization of analytical approaches, more complete and reliable data collection methods, and a better understanding of toxicity mechanisms. JF - Clinical pharmacology and therapeutics AU - Kruhlak, N L AU - Benz, R D AU - Zhou, H AU - Colatsky, T J AD - Division of Drug Safety Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 529 EP - 534 VL - 91 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Drug and Narcotic Control -- methods KW - Decision Making KW - Drug Industry -- methods KW - Models, Theoretical KW - Quantitative Structure-Activity Relationship KW - Drug-Related Side Effects and Adverse Reactions KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/922501343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Challenges+in+Development+of+Melamine+Analysis+in+Food+Contamination&rft.au=Krynitsky%2C+Alexander&rft.aulast=Krynitsky&rft.aufirst=Alexander&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-26 N1 - Date created - 2012-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2011.300 ER - TY - JOUR T1 - Environmental fate of polyhexamethylene biguanide. AN - 921424785; 22037631 AB - Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the exception of sandy soil. PHMB was absorbed to below detectable levels by weathered concrete within 12 h. In addition, one over the counter wound care product containing PHMB was evaluated to assess environmental leaching; detectable levels (20 μg/mL) were still present after 1 week. JF - Bulletin of environmental contamination and toxicology AU - Lucas, Anne D AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, OSEL/DB, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. anne.lucas@fda.hhs.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 322 EP - 325 VL - 88 IS - 3 KW - Anti-Bacterial Agents KW - 0 KW - Biguanides KW - Soil KW - Soil Pollutants KW - Water Pollutants, Chemical KW - polihexanide KW - 322U039GMF KW - Index Medicus KW - Environmental Monitoring KW - Fresh Water -- chemistry KW - Equipment and Supplies KW - Kinetics KW - Soil -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Anti-Bacterial Agents -- analysis KW - Biguanides -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/921424785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+environmental+contamination+and+toxicology&rft.atitle=Environmental+fate+of+polyhexamethylene+biguanide.&rft.au=Lucas%2C+Anne+D&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2012-03-01&rft.volume=88&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+environmental+contamination+and+toxicology&rft.issn=1432-0800&rft_id=info:doi/10.1007%2Fs00128-011-0436-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-30 N1 - Date created - 2012-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00128-011-0436-3 ER - TY - JOUR T1 - Perfluorinated compounds and subfecundity in pregnant women. AN - 921143530; 22081060 AB - Perfluorinated compounds are ubiquitous pollutants; epidemiologic data suggest they may be associated with adverse health outcomes, including subfecundity. We examined subfecundity in relation to 2 perfluorinated compounds-perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). This case-control analysis included 910 women enrolled in the Norwegian Mother and Child Cohort Study in 2003 and 2004. Around gestational week 17, women reported their time to pregnancy and provided blood samples. Cases consisted of 416 women with a time to pregnancy greater than 12 months, considered subfecund. Plasma concentrations of perfluorinated compounds were analyzed using liquid chromatography-mass spectrometry. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for each pollutant quartile using logistic regression. Estimates were further stratified by parity. The median plasma concentration of PFOS was 13.0 ng/mL (interquartile range [IQR] = 10.3-16.6 ng/mL) and of PFOA was 2.2 ng/mL (IQR = 1.7-3.0 ng/mL). The relative odds of subfecundity among parous women was 2.1 (95% CI = 1.2-3.8) for the highest PFOS quartile and 2.1 (1.0-4.0) for the highest PFOA quartile. Among nulliparous women, the respective relative odds were 0.7 (0.4-1.3) and 0.5 (0.2-1.2). Previous studies suggest that the body burden of perfluorinated compounds decreases during pregnancy and lactation through transfer to the fetus and to breast milk. Afterward, the body burden may increase again. Among parous women, increased body burden may be due to a long interpregnancy interval rather than the cause of a long time to pregnancy. Therefore, data from nulliparous women may be more informative regarding toxic effects of perfluorinated compounds. Our results among nulliparous women did not support an association with subfecundity. JF - Epidemiology (Cambridge, Mass.) AU - Whitworth, Kristina W AU - Haug, Line S AU - Baird, Donna D AU - Becher, Georg AU - Hoppin, Jane A AU - Skjaerven, Rolv AU - Thomsen, Cathrine AU - Eggesbo, Merete AU - Travlos, Gregory AU - Wilson, Ralph AU - Longnecker, Matthew P AD - Department of Health and Human Services, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA. whitworthkw@niehs.nih.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 257 EP - 263 VL - 23 IS - 2 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - Parity KW - Odds Ratio KW - Norway -- epidemiology KW - Pregnancy -- drug effects KW - Logistic Models KW - Humans KW - Body Burden KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Case-Control Studies KW - Female KW - Caprylates -- blood KW - Caprylates -- adverse effects KW - Fluorocarbons -- blood KW - Fluorocarbons -- adverse effects KW - Alkanesulfonic Acids -- blood KW - Alkanesulfonic Acids -- adverse effects KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/921143530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Perfluorinated+compounds+and+subfecundity+in+pregnant+women.&rft.au=Whitworth%2C+Kristina+W%3BHaug%2C+Line+S%3BBaird%2C+Donna+D%3BBecher%2C+Georg%3BHoppin%2C+Jane+A%3BSkjaerven%2C+Rolv%3BThomsen%2C+Cathrine%3BEggesbo%2C+Merete%3BTravlos%2C+Gregory%3BWilson%2C+Ralph%3BLongnecker%2C+Matthew+P&rft.aulast=Whitworth&rft.aufirst=Kristina&rft.date=2012-03-01&rft.volume=23&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e31823b5031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-25 N1 - Date created - 2012-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Toxicol. 2001 Mar-Apr;20(2):101-9 [11354466] Environ Sci Technol. 2010 Dec 15;44(24):9550-6 [21090747] Environ Sci Technol. 2002 Apr 1;36(7):146A-152A [11999053] Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-84 [15328768] J Epidemiol Community Health. 1995 Jun;49(3):314-9 [7629471] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] Int J Epidemiol. 2006 Oct;35(5):1146-50 [16926217] Tohoku J Exp Med. 2007 May;212(1):63-70 [17464105] Environ Health Perspect. 2007 Sep;115(9):1298-305 [17805419] Toxicol Sci. 2007 Oct;99(2):366-94 [17519394] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Environ Health Perspect. 2007 Nov;115(11):1670-6 [18008002] Environ Health Perspect. 2007 Nov;115(11):1677-82 [18008003] Environ Sci Technol. 2008 Jul 1;42(13):4989-95 [18678038] J Chromatogr A. 2009 Jan 16;1216(3):385-93 [19026423] Int J Hyg Environ Health. 2009 May;212(3):239-70 [18565792] Hum Reprod. 2009 May;24(5):1200-5 [19176540] Environ Sci Technol. 2009 Mar 15;43(6):2131-6 [19368225] Reprod Toxicol. 2009 Jun;27(3-4):319-30 [19162172] Reprod Toxicol. 2009 Jun;27(3-4):212-30 [19429401] Environ Sci Technol. 2009 Apr 1;43(7):2641-7 [19452929] Epidemiology. 2010 Jan;21(1):160-1; author reply 161 [20010224] Environ Int. 2010 Aug;36(6):584-92 [20494442] Rev Environ Contam Toxicol. 2010;208:161-77 [20811864] Environ Sci Technol. 2010 Sep 15;44(18):7123-9 [20722423] Anal Bioanal Chem. 2010 Nov;398(6):2413-27 [20680618] Environ Int. 2011 Jan;37(1):178-83 [20880590] Comment In: Epidemiology. 2012 Mar;23(2):264-6 [22317809] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e31823b5031 ER - TY - JOUR T1 - A shell-based magnetic field model for magnetic proximity detection systems AN - 920792522; 16208866 AB - Several magnetic proximity detection systems have been developed for mining vehicles and mobile machinery to protect nearby workers. Magnetic field generators are often used in these systems to establish magnetic fields around the equipment. A sensor worn by a worker provides a measurement of the magnetic flux density that is used to estimate the proximity to the machine. The proximity detection systems currently available for underground mining equipment are capable of identifying whether a worker is near the machine. However, it is a challenge for these systems to accurately locate the worker. Mining machines, which have fast-moving, articulated parts, present hazards that change depending on the situation at hand as well as the specific location of the worker. In addition, the dynamic nature and confined spaces of the mining environment often demand that the workers be close to the machinery. Therefore, in many cases, simply knowing the proximity of a worker may be inadequate. To provide the most effective protection, it would be advantageous to know the worker's exact location relative to specific parts of the machine. To lay the foundation for measuring such a location, we have developed a shell-based model of the magnetic flux density distribution for a ferrite-cored generator. This paper will present an analysis of the model along with a model construction process. Also presented are the laboratory test results of a prototype system that implements this model to determine the exact location of a magnetic sensor using the fields from two generators. JF - Safety Science AU - Li, Jingcheng AU - Carr, Jacob AU - Jobes, Christopher AD - The National Institute for Occupational Safety and Health, 626 Cochran's Mill Road, Pittsburgh, PA 15236, USA, Jingcheng.Li@cdc.hhs.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 463 EP - 471 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 50 IS - 3 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Magnetic proximity detection system KW - Magnetic field generator KW - Shell-based magnetic flux density model KW - Warning zone KW - Stop zone KW - mining equipment KW - Sensors KW - Laboratory testing KW - Machinery KW - confined spaces KW - magnetic fields KW - Mining KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=A+shell-based+magnetic+field+model+for+magnetic+proximity+detection+systems&rft.au=Li%2C+Jingcheng%3BCarr%2C+Jacob%3BJobes%2C+Christopher&rft.aulast=Li&rft.aufirst=Jingcheng&rft.date=2012-03-01&rft.volume=50&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2011.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - mining equipment; Laboratory testing; Sensors; Machinery; confined spaces; magnetic fields; Mining; Construction industry DO - http://dx.doi.org/10.1016/j.ssci.2011.10.007 ER - TY - JOUR T1 - A CART technique to adjust production from longwall coal operations under ventilation constraints AN - 920792507; 16208863 AB - Methane emissions in longwall coal mines can arise from a variety of geologic and production factors, where ventilation and degasification are primary control measures to prevent excessive methane levels. However, poor ventilation practices or inadequate ventilation may result in accumulation of dangerous methane-air mixtures. The need exists for a set of rules and a model to be used as guidelines to adjust coal production according to expected methane emissions and current ventilation conditions. In this paper, hierarchical classification and regression tree (CART) analyses are performed as nonparametric modeling efforts to predict methane emissions that can arise during extraction of a longwall panel. These emissions are predicted for a range of coal productivities while considering specific operational, panel design and geologic parameters such as gas content, proximate composition of coal, seam height, panel width, cut height, cut depth, and panel size. Analyses are conducted for longwall mines with and without degasification of the longwall panel. These models define a range of coal productivities that can be achieved without exceeding specified emissions rates under given operating and geological conditions. Finally, the technique was applied to longwall mines that operate with and without degasification system to demonstrate its use and predictive capability. The predicted results proved to be close to the actual measurements to estimate ventilation requirements. Thus, the CART-based model that is given in this paper can be used to predict methane emission rates and to adjust operation parameters under ventilation constrains in longwall mining. JF - Safety Science AU - Karacan, COezgen AU - Goodman, Gerrit VR AD - National Institute of Occupational Safety and Health (NIOSH), Office of Mine Safety and Health Research (OMSHR), Dust Control, Ventilation, and Toxic Substances Branch, Pittsburgh, PA 15236, United States, cok6@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 510 EP - 522 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 50 IS - 3 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Mining safety KW - Coal mine methane KW - Methane emissions KW - Longwall mines KW - CART analyses KW - Methane KW - safety engineering KW - Ventilation KW - guidelines KW - Emissions KW - Emission measurements KW - Geology KW - Coal KW - Mines KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=A+CART+technique+to+adjust+production+from+longwall+coal+operations+under+ventilation+constraints&rft.au=Karacan%2C+COezgen%3BGoodman%2C+Gerrit+VR&rft.aulast=Karacan&rft.aufirst=COezgen&rft.date=2012-03-01&rft.volume=50&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2011.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Methane; safety engineering; Ventilation; guidelines; Emission measurements; Emissions; Geology; Coal; Mines DO - http://dx.doi.org/10.1016/j.ssci.2011.11.002 ER - TY - JOUR T1 - Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach. AN - 916851426; 22044848 AB - Iron can cause oxidative stress and DNA damage, and heme iron can catalyze endogenous formation of N-nitroso compounds, which are potent carcinogens. Dietary iron promotes esophageal cancer incidence in animal studies and has been identified as a growth factor for Helicobacter pylori, an established risk factor for stomach cancer. We conducted a population-based case-control study of adenocarcinoma of the esophagus (n=124) and stomach (n=154) and 449 controls in Nebraska. Heme iron and total iron intake were estimated from a food frequency questionnaire and databases of heme and total iron. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for known risk factors. Esophageal cancer was positively associated with higher intakes of heme iron (ORQ4 vs. Q1=3.04, 95% CI: 1.20-7.72; P trend=0.009) and total iron from meat sources (ORQ4 vs. Q1=2.67, 95% CI: 0.99-7.16; P trend=0.050). Risk of stomach cancer was elevated among those with higher intakes of heme iron (ORQ4 vs.Q1=1.99, 95% CI: 1.00-3.95; P trend=0.17) and total iron from meat (OR=2.26, 95% CI: 1.14-4.46; P trend=0.11). Iron intake from all dietary sources was not significantly associated with risk of either cancer. Our results suggest that high intakes of heme and iron from meat may be important dietary risk factors for esophageal and stomach cancer and may partly explain associations with red meat. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Ward, Mary H AU - Cross, Amanda J AU - Abnet, Christian C AU - Sinha, Rashmi AU - Markin, Rodney S AU - Weisenburger, Dennis D AD - Department of Health and Human Services, Occupational and Environmental Epidemiology Branch , National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. wardm@mail.nih.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 134 EP - 138 VL - 21 IS - 2 KW - Iron, Dietary KW - 0 KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Young Adult KW - Eating -- physiology KW - Feeding Behavior -- physiology KW - Humans KW - Aged KW - Nutrition Surveys KW - Heme -- adverse effects KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Heme -- analysis KW - Female KW - Male KW - Adenocarcinoma -- epidemiology KW - Meat -- adverse effects KW - Iron, Dietary -- analysis KW - Adenocarcinoma -- etiology KW - Iron, Dietary -- adverse effects KW - Meat -- analysis KW - Stomach Neoplasms -- epidemiology KW - Stomach Neoplasms -- etiology KW - Esophageal Neoplasms -- etiology KW - Iron, Dietary -- administration & dosage KW - Esophageal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916851426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Heme+iron+from+meat+and+risk+of+adenocarcinoma+of+the+esophagus+and+stomach.&rft.au=Ward%2C+Mary+H%3BCross%2C+Amanda+J%3BAbnet%2C+Christian+C%3BSinha%2C+Rashmi%3BMarkin%2C+Rodney+S%3BWeisenburger%2C+Dennis+D&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2012-03-01&rft.volume=21&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e32834c9b6c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-07 N1 - Date created - 2012-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2001 Aug;22(8):1119-29 [11470739] Nutr Cancer. 2002;42(1):33-40 [12235648] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 1985 Jul;122(1):13-26 [4014190] Epidemiology. 1990 Sep;1(5):349-56 [2078610] Epidemiology. 1990 Jan;1(1):58-64 [2081241] Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):305-12 [8348053] Int J Cancer. 1995 Jan 17;60(2):160-2 [7829208] Alcohol. 1995 Mar-Apr;12(2):97-104 [7772272] Cancer Lett. 1995 Jun 29;93(1):17-48 [7600541] Int J Cancer. 1996 Mar 28;66(1):130-4 [8608956] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] J Gastroenterol Hepatol. 1999 Mar;14(3):202-14 [10197487] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Int J Cancer. 2005 Nov 20;117(4):643-7 [15929082] Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Am J Gastroenterol. 2011 Mar;106(3):432-42 [20978481] Cancer Causes Control. 2010 Dec;21(12):2269-79 [20936528] Int J Occup Environ Health. 2008 Jul-Sep;14(3):193-7 [18686719] Carcinogenesis. 2007 Mar;28(3):685-90 [17052997] World J Gastroenterol. 2006 Jul 21;12(27):4296-303 [16865769] Carcinogenesis. 2006 Jul;27(7):1497-501 [16571648] J Natl Cancer Inst. 2006 Mar 1;98(5):345-54 [16507831] Eur J Gastroenterol Hepatol. 2000 Dec;12(12):1263-5 [11192313] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e32834c9b6c ER - TY - JOUR T1 - Survey of polycyclic aromatic hydrocarbons in marine products in Korea using GC/MS AN - 1660418909; 17588501 AB - This study investigates polycyclic aromatic hydrocarbons (PAHs) in marine products on the Korean market. A total of 280 samples of fish (n = 100), shellfish (n = 80), cephalopod (n = 60) and crustacea (n = 40) were collected for analyses of PAHs (naphthalene, acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, indeno[1,2,3-c,d]pyrene, dibenz[a,h]anthracene and benzo[g,h,i]perylene). The analytical procedure was based on the matrix solid-phase dispersion on Florisil cartridges and extraction with hexane/dichloromethane (3:1, v/v). The PAHs were determined by gas chromatography with mass spectrometric detection using selective ion monitoring. Average recoveries for all the PAHs studied were in the range 58-79%. The sum of 16 PAHs concentrations in fish, shellfish, cephalopod/crustacea were in the range 0.2-0.5, 1.2-1.6 and 0.8-1.9 mu g/kg, respectively. JF - Food Additives & Contaminants: Part B - Surveillance Communications AU - Hwang, Kyungmi AU - Woo, Sungmin AU - Choi, Jangduck AU - Kim, Meehye AD - Imported Food Analysis Division, Korea Food and Drug Administration, 120 Juan-1-dong, Nam-gu, Incheon 402-835, South Korea, meehkim@korea.kr Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 1 EP - 7 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 5 IS - 1 SN - 1939-3210, 1939-3210 KW - Toxicology Abstracts KW - PAH KW - fish and fish products KW - Fluoranthene KW - Anthracene KW - acenaphthene KW - fluorene KW - Polycyclic aromatic hydrocarbons KW - Crustacea KW - Naphthalene KW - Pyrene KW - Food contamination KW - Chrysene KW - Food additives KW - Phenanthrene KW - Dichloromethane KW - Gas chromatography KW - Benzo(a)pyrene KW - n-Hexane KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660418909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+of+polycyclic+aromatic+hydrocarbons+in+marine+products+in+Korea+using+GC%2FMS&rft.au=Hwang%2C+Kyungmi%3BWoo%2C+Sungmin%3BChoi%2C+Jangduck%3BKim%2C+Meehye&rft.aulast=Hwang&rft.aufirst=Kyungmi&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Anthracene; Fluoranthene; Polycyclic aromatic hydrocarbons; fluorene; acenaphthene; Naphthalene; Pyrene; Food contamination; Chrysene; Phenanthrene; Food additives; Dichloromethane; Gas chromatography; Benzo(a)pyrene; n-Hexane; Crustacea DO - http://dx.doi.org/10.1080/19393210.2011.611897 ER - TY - JOUR T1 - Shift work and the incidence of injury among police officers AN - 1560138167; 19416352 AB - Background Police officers may be injury prone due to fatigue, erratic work hours, and insufficient sleep. This study explored injury incidence among police officers across shifts. Methods Day-to-day shift data from computerized payroll records (1994-2010) were available from a mid-sized urban police department (n=430). Sleep duration, shift activity level, returning to work after days off, and injury incidence over time were also examined. Results Age-adjusted incidence rate ratio (IRR) for injury on the midnight shift was 72% larger than the day shift (IRR=1.72; 95% CI=1.26-2.36) and 66% larger than the afternoon shift (IRR=1.66; 95% CI=1.23-2.25). Injury incidence for the first day back on the midnight shift was 69% larger than day shift (IRR=1.69; 95% CI=1.23-2.32) and 54% larger than the afternoon shift (IRR=1.54; 95% CI=1.36-1.76). High activity level combined with midnight shift work put officers at increased injury risk (IRR=2.31; P=0.0003). Probability of remaining free of injury was significantly higher for day shift than midnight shift (P<0.0001). Conclusions Higher injury risk was associated with night shift work in police officers. Night shift combined with high work activity was strongly associated with injury risk. There was a significantly higher probability of not being injured on day compared to midnight or afternoon shifts. Am. J. Ind. Med. 55:217-227, 2012. copyright 2011 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Violanti, John M AU - Fekedulegn, Desta AU - Andrew, Michael E AU - Charles, Luenda E AU - Hartley, Tara A AU - Vila, Bryan AU - Burchfiel, Cecil M AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia., violanti@buffalo.edu Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 217 EP - 227 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 55 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - police KW - occupational injury KW - shift work KW - work hours KW - fatigue KW - sleep KW - activity levels KW - Health risks KW - Shift work KW - Fatigue KW - Injuries KW - Police KW - Working conditions KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560138167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Shift+work+and+the+incidence+of+injury+among+police+officers&rft.au=Violanti%2C+John+M%3BFekedulegn%2C+Desta%3BAndrew%2C+Michael+E%3BCharles%2C+Luenda+E%3BHartley%2C+Tara+A%3BVila%2C+Bryan%3BBurchfiel%2C+Cecil+M&rft.aulast=Violanti&rft.aufirst=John&rft.date=2012-03-01&rft.volume=55&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Shift work; Health risks; Fatigue; Injuries; Police; Working conditions DO - http://dx.doi.org/10.1002/ajim.22007 ER - TY - JOUR T1 - Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment AN - 1443366850; 18507726 AB - Context. Healthcare worker exposure to antineoplastic drugs continues to be reported despite safe handling guidelines published by several groups. Sensitive sampling and analytical methods are needed so that occupational safety and health professionals may accurately assess environmental and biological exposure to these drugs in the workplace.Objective. To develop liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analytical methods for measuring five antineoplastic drugs in samples from the work environment, and to apply these methods in validating sampling methodology. A single method for quantifying several widely used agents would decrease the number of samples required for method development, lower cost, and time of analysis. Methods for measuring these drugs in workers' urine would also be useful in monitoring personal exposure levels.Results. LC-MS/MS methods were developed for individual analysis of five antineoplastic drugs in wipe and air sample media projected for use in field sampling: cyclophosphamide, ifosfamide, paclitaxel, doxorubicin, and 5-fluorouracil. Cyclophosphamide, ifosfamide, and paclitaxel were also measured simultaneously in some stages of the work. Extraction methods for air and wipe samples were developed and tested using the aforementioned analytical methods. Good recoveries from the candidate air and wipe sample media for most of the compounds, and variable recoveries for test wipe samples depending on the surface under study, were observed. Alternate LC-MS/MS methods were also developed to detect cyclophosphamide and paclitaxel in urine samples.Conclusions. The sampling and analytical methods were suitable for determining worker exposure to antineoplastics via surface and breathing zone contamination in projected surveys of healthcare settings. JF - Journal of Oncology Pharmacy Practice AU - Pretty, Jack R AU - Connor, Thomas H AU - Spasojevic, Ivan AU - Kurtz, Kristine S AU - McLaurin, Jeffrey L AU - B'Hymer, Clayton AU - Debord, D Gayle AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Cincinnati, OH, USA  , jrp0@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 23 EP - 36 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 18 IS - 1 SN - 1078-1552, 1078-1552 KW - Health & Safety Science Abstracts KW - Health care KW - Urine KW - Guidelines KW - Air sampling KW - Antineoplastic drugs KW - Drugs KW - Occupational exposure KW - Medical personnel KW - Spectrometry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443366850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Oncology+Pharmacy+Practice&rft.atitle=Sampling+and+mass+spectrometric+analytical+methods+for+five+antineoplastic+drugs+in+the+healthcare+environment&rft.au=Pretty%2C+Jack+R%3BConnor%2C+Thomas+H%3BSpasojevic%2C+Ivan%3BKurtz%2C+Kristine+S%3BMcLaurin%2C+Jeffrey+L%3BB%27Hymer%2C+Clayton%3BDebord%2C+D+Gayle&rft.aulast=Pretty&rft.aufirst=Jack&rft.date=2012-03-01&rft.volume=18&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Oncology+Pharmacy+Practice&rft.issn=10781552&rft_id=info:doi/10.1177%2F1078155210389215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Number of references - 28 N1 - Last updated - 2013-10-21 N1 - SubjectsTermNotLitGenreText - Health care; Urine; Guidelines; Air sampling; Antineoplastic drugs; Drugs; Medical personnel; Occupational exposure; Spectrometry DO - http://dx.doi.org/10.1177/1078155210389215 ER - TY - JOUR T1 - Caribbean ciguatoxin profile in raw and cooked fish implicated in ciguatera AN - 1356926996; 15910319 AB - A cooked meal remnant and uncooked portion of a Caribbean barracuda suspected in ciguatera fish poisoning were examined for the presence of ciguatoxins (CTX). Samples were analysed using a tiered method of CTX analysis consisting of in vitro cell (N2a) assay to assess composite toxicity and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for structural confirmation. Meal remnant and uncooked fish extracts were cytotoxic by N2a cell assay and Caribbean ciguatoxin congener C-CTX-1 was structurally confirmed. Sample extracts were fractionated by LC and fractions analysed by the cell assay. The cytotoxicity profiles of cooked meal remnant and uncooked fish were similar. Cytotoxicity-guided LC-MS/MS analyses identified several CTX congeners contributing to the composite toxicity of the samples. C-CTX-1 was a major contributor, supporting its utility as a biomarker of Caribbean ciguatoxic fish. JF - Food Chemistry AU - Abraham, Ann AU - Jester, Edward LE AU - Granade, Hudson R AU - Plakas, Steven M AU - Dickey, Robert W AD - FDA, Division of Seafood Science & Technology, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528-0158, USA, ann.abraham@fda.hhs.gov Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 192 EP - 198 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 131 IS - 1 SN - 0308-8146, 0308-8146 KW - ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Ciguatoxins KW - Ciguatera fish poisoning KW - Toxin profile KW - Caribbean KW - Poisoning KW - Toxicity KW - Biomarkers KW - biomarkers KW - Mass spectroscopy KW - Ciguatera KW - Cytotoxicity KW - ASW, Caribbean Sea KW - Fish poisoning KW - Congeners KW - Ciguatoxin KW - X 24320:Food Additives & Contaminants KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356926996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Caribbean+ciguatoxin+profile+in+raw+and+cooked+fish+implicated+in+ciguatera&rft.au=Abraham%2C+Ann%3BJester%2C+Edward+LE%3BGranade%2C+Hudson+R%3BPlakas%2C+Steven+M%3BDickey%2C+Robert+W&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2012-03-01&rft.volume=131&rft.issue=1&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2011.08.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Fish poisoning; Biomarkers; Toxicity; Ciguatoxin; Ciguatera; Poisoning; Congeners; biomarkers; Mass spectroscopy; ASW, Caribbean Sea DO - http://dx.doi.org/10.1016/j.foodchem.2011.08.059 ER - TY - JOUR T1 - ACCIDENTS IN FIXED-WING AIRCRAFT DURING INSTRUCTIONAL FLIGHTS AN - 1348488118; 17906644 AB - INTRODUCTION: Flight training is generally considered one of the safest categories of general aviation; however no type of flying is without risk. The purpose of this study was to identify risk factors for accidents involving flight instruction in fixed-wing aircraft. METHODS: National Transportation Safety Board accident data were used to identify accidents that occurred during instructional flights in fixed-wing aircraft during 1999-2010. Instructional flights were a part of flight training, those that required instructor supervision or presence onboard. Narrative reports were reviewed to determine primary or secondary student status and whether a flight instructor was present. Data were then analyzed to determine phase of flight, location, circumstances and causes. RESULTS: During 1999-2010, 2488 instructional flights were involved in 2474 accidents during civilian flight training operations, resulting in 491 fatalities and 290 serious injuries. The majority of these instructional flights involved primary students (67%, 1673) and over half (55%, 1370) occurred with a certificated flight instructor in the airplane. The most frequent occurrences were loss of control on ground or water (24%), loss of control in flight (15%), hard landing (15%) and loss of engine power (13%). One hundred accidents resulted from fuel starvation or exhaustion; 65 of these accidents had instructors in the aircraft. Instructor's inaction or improper action was identified by the NTSB as a primary factor in almost half (48%, 659) of the accident flights with an instructor onboard. A majority of the accidents occurred on an airstrip (68%); the most common phases of flight in which accidents took place were landing (34%, 857) and takeoff (12%, 297). DISCUSSION: These data indicate a need for increased attentiveness and improved supervision of students by flight instructors. Instructor proficiency in emergency procedures and maneuvers and setting conservative criteria for safe flight operations, including fuel reserves, winds and altitudes may prevent future accidents. Capable instructors may prevent accidents during dual flight and by imparting the skills, knowledge and judgment for safe solo flight by students. JF - Aviation, Space, and Environmental Medicine AU - O'Connor, M B AU - Mode, N A AU - Lincoln, J M AD - APRO, CDC/NIOSH, Anchorage, AK Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 338 EP - 339 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 83 IS - 3 SN - 0095-6562, 0095-6562 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Accidents KW - Altitude KW - Transportation KW - Aircraft KW - Training KW - Fuels KW - Reviews KW - Risk factors KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1348488118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluating+the+Sensitivity+of+Library-Based+Spectral+Correlation+Methods+and+Their+Transferability+Between+Different+Spectrometers&rft.au=Rodriguez%2C+Jason%3BBuhse%2C+Lucinda%3BWestenberger%2C+Benjamin%3BKauffman%2C+John&rft.aulast=Rodriguez&rft.aufirst=Jason&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; Altitude; Accidents; Transportation; Aircraft; Training; Risk factors; Reviews; Fuels ER - TY - JOUR T1 - From The Office Of The National Coordinator: The Strategy For Advancing The Exchange Of Health Information AN - 1266147720; 201300325 AB - Electronic health information exchange addresses a critical need in the US health care system to have information follow patients to support patient care. Today little information is shared electronically, leaving doctors without the information they need to provide the best care. With payment reforms providing a strong business driver, the demand for health information exchange is poised to grow. The Office of the National Coordinator for Health Information Technology, Department of Health and Human Services, has led the process of establishing the essential building blocks that will support health information exchange. Over the coming year, this office will develop additional policies and standards that will make information exchange easier and cheaper and facilitate its use on a broader scale. Adapted from the source document. JF - Health Affairs AU - Williams, Claudia AU - Mostashari, Farzad AU - Mertz, Kory AU - Hogin, Emily AU - Atwal, Parmeeth AD - State Health Information Exchange Program, Health Information Technology (ONC), Department of Health and Human Services, in Washington, D.C claudia.williams@hhs.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 527 EP - 536 PB - Project HOPE, Bethesda MD VL - 31 IS - 3 SN - 0278-2715, 0278-2715 KW - Human Services KW - Information Technology KW - United States of America KW - Physicians KW - Patients KW - Health KW - Reform KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266147720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=From+The+Office+Of+The+National+Coordinator%3A+The+Strategy+For+Advancing+The+Exchange+Of+Health+Information&rft.au=Williams%2C+Claudia%3BMostashari%2C+Farzad%3BMertz%2C+Kory%3BHogin%2C+Emily%3BAtwal%2C+Parmeeth&rft.aulast=Williams&rft.aufirst=Claudia&rft.date=2012-03-01&rft.volume=31&rft.issue=3&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.1314 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care Services; Health; Patients; Human Services; Reform; Physicians; United States of America; Information Technology DO - http://dx.doi.org/10.1377/hlthaff.2011.1314 ER - TY - BOOK T1 - World Trade Center Chemicals of Potential Concern and Selected Other Chemical Agents: Summary of Cancer Classifications by the National Toxicology Program and International Agency for Research on Cancer AN - 1151044182; 2011-314259 AB - The National Institute for Occupational Safety and Health (NIOSH) presented the first periodic review of cancer for the WTC Health Program in July 2011. This review included findings from the peer-reviewed scientific and medical literature about exposures and cancer resulting from the September 11, 2001, terrorist attacks [NIOSH 2011]. The Exposure section of the first periodic review provided an initial list of agents detected in the area around the World Trade Center (WTC) during the disaster response and recovery periods. Tables, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Mar 2012, 60 pp. AU - World Trade Center Health Program Cancer Working Group Y1 - 2012/03// PY - 2012 DA - March 2012 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Occupational health and safety KW - Health conditions and policy - Diseases and disorders KW - Education and education policy - Statistics, research, research methods, and research support KW - International relations - International relief and humanitarian assistance KW - Administration of justice - Crime and criminals KW - International relations - International relations KW - Disaster relief KW - Chemicals KW - World trade center KW - Classification KW - United States Occupational safety and health administration KW - International agencies KW - Cancer KW - Industrial safety KW - Terrorists KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1151044182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=World+Trade+Center+Health+Program+Cancer+Working+Group&rft.aulast=World+Trade+Center+Health+Program+Cancer+Working+Group&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.title=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2012-115/pdfs/2012-115.pdf LA - English DB - PAIS Index N1 - Date revised - 2012-11-01 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2012 N1 - SuppNotes - NIOSH Publication Number 2012-115 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Ergonomics in design: interventions for youth working in the agricultural industry AN - 1038600407; 17034110 AB - Youth and adolescents make up a substantial segment of the working population in the agricultural industry and many of these young workers are required to perform physically demanding jobs that put them at significant risk for developing work-related musculoskeletal disorders (MSDs). Although there are no surveillance systems in place to track these potential injuries for youth who work in agriculture, based on our understanding of the magnitude of risk for these tasks, a number of interventions have been developed and evaluated that should reduce the risk of MSDs for youth who perform these high risk tasks. The purpose of this article is to raise the research community's awareness to the risk of work-related MSDs for youth who work in agriculture and to demonstrate that ergonomic designers are best suited to develop cost-effective interventions for use in these tasks that can be easily implemented. JF - Theoretical Issues in Ergonomics Science AU - Waters, Thomas R AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 270 EP - 285 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 2 SN - 1463-922X, 1463-922X KW - Risk Abstracts; Health & Safety Science Abstracts KW - youth KW - farms KW - lifting KW - musculoskeletal disorders KW - Agriculture KW - Economics KW - Intervention KW - Risk reduction KW - Ergonomics KW - Working conditions KW - Adolescents KW - Design KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038600407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=The+Role+of+Quality+by+Design+in+Process+Analytical+Technology+%28PAT%29+and+Real+Time+Release+Testing+%28RTRT%29+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Agriculture; Economics; Intervention; Risk reduction; Adolescents; Working conditions; Ergonomics; Occupational health; Design DO - http://dx.doi.org/10.1080/1463922X.2010.497196 ER - TY - JOUR T1 - Post-Hire Asthma Among Insect-Rearing Workers AN - 1020856796; 16507823 AB - Objective: To evaluate the incidence of post-hire asthma (PHA) among insect-rearing workers, defined as asthma, the symptoms of which appeared after hire at the current workplace. Methods: We surveyed the health of workers at three insect-rearing facilities and an associated office facility. We calculated the incidence and estimated hazard ratios for PHA. Results: Post-hire asthma incidence in 157 insect-rearing workers was 16.2 per 1000 person-years compared with 9.2 per 1,000 person-years in 70 office workers. Workers with predominant exposure to Lepidoptera had an incidence of 26.9 per 1000 person-years and a hazard ratio of 5.5 (95% confidence interval: 1.6 to 23.9) adjusted for sex, race, and parental asthma. In contrast, the presence of specific immunoglobulin E to Lepidoptera antigens was not associated with PHA. Conclusion: Insect-rearing workers had a high incidence of PHA, primarily accounted for by workplace exposure to Lepidoptera. JF - Journal of Occupational and Environmental Medicine AU - Suarthana, E AU - Shen, A AU - Henneberger, P K AU - Kreiss, K AU - Leppla, N C AU - Bueller, D AU - Lewis, D M AU - Bledsoe, T A AU - Janotka, E AU - Petsonk, EL AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown WV 26505, USA, elp2@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 310 EP - 317 VL - 54 IS - 3 SN - 1076-2752, 1076-2752 KW - Entomology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Workers KW - Immunoglobulin E KW - Asthma KW - Respiratory diseases KW - Occupational exposure KW - Lepidoptera KW - Z 05300:General KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020856796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Post-Hire+Asthma+Among+Insect-Rearing+Workers&rft.au=Suarthana%2C+E%3BShen%2C+A%3BHenneberger%2C+P+K%3BKreiss%2C+K%3BLeppla%2C+N+C%3BBueller%2C+D%3BLewis%2C+D+M%3BBledsoe%2C+T+A%3BJanotka%2C+E%3BPetsonk%2C+EL&rft.aulast=Suarthana&rft.aufirst=E&rft.date=2012-03-01&rft.volume=54&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823fe098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Workers; Immunoglobulin E; Asthma; Occupational exposure; Respiratory diseases; Lepidoptera DO - http://dx.doi.org/10.1097/JOM.0b013e31823fe098 ER - TY - JOUR T1 - Disaster Preparedness of Linguistically Isolated Populations: Practical Issues for Planners AN - 1018384488; 201207888 AB - In the absence of culturally and linguistically appropriate disaster preparedness plans, several linguistically isolated and culturally diverse population groups are disproportionately disadvantaged in the United States. The communication gap poses challenges to emergency preparedness planners and response personnel in predisaster communication and postdisaster response efforts. Houston Department of Health and Human Services aimed to develop practical recommendations for local emergency response personnel so as to improve dissemination of emergency information and equitable delivery of services to linguistically isolated communities in the greater Houston area. Sixteen focus group discussions were conducted among linguistically isolated immigrant populations living in the greater Houston metropolitan area who primarily spoke one of the Spanish, Chinese, Vietnamese, and Somali languages. Our questions focused on general knowledge and understanding of disasters and explored experiences during Houston's most recent disaster, Hurricane Ike. We found that (a) understanding of disaster and preparedness is contextual, (b) awareness of preparedness needs and actual plans among LIPs is inadequate, and (c) word of mouth is the preferred information source for linguistically isolated groups. Disaster preparedness plans of a given jurisdiction should reflect the culturally and linguistically appropriate components addressing the needs, concerns, context-based knowledge or awareness, and perceptions of linguistically isolated populations. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Promotion Practice AU - Nepal, Vishnu AU - Banerjee, Deborah AU - Perry, Mark AU - Scott, Deborah AD - Houston Department of Health and Human Services, Texas Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 265 EP - 271 VL - 13 IS - 2 SN - 1524-8399, 1524-8399 KW - Texas (88950) KW - Communication (13600) KW - Language Policy (43450) KW - United States of America (92750) KW - Minority Groups (54240) KW - Military Language (54050) KW - Immigrants (34670) KW - article KW - 5611: sociolinguistics; language planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018384488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Disaster+Preparedness+of+Linguistically+Isolated+Populations%3A+Practical+Issues+for+Planners&rft.au=Nepal%2C+Vishnu%3BBanerjee%2C+Deborah%3BPerry%2C+Mark%3BScott%2C+Deborah&rft.aulast=Nepal&rft.aufirst=Vishnu&rft.date=2012-03-01&rft.volume=13&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Military Language (54050); Communication (13600); Minority Groups (54240); Immigrants (34670); United States of America (92750); Texas (88950); Language Policy (43450) ER - TY - JOUR T1 - Occupational Safety and Health in the USA: Now and the Future AN - 1014105073; 16644574 AB - In the USA, national worker protection legislation was enacted in 1970. The legislation required that research, recommendations and guidance be developed to aid employers and workers, that workplace health and safety standards be adopted, that employer comply with those rules and that the government police employer compliance, and that assistance be offered to employers and workers to help them maintain a safe and healthful workplace. In the 40 yr since passage of the Occupational Safety and Health Act of 1970, worker injury, illness and fatalities have declined but not been eliminated. Efforts to accelerate the standards adoption process are much discussed in the USA along with how to protect workers from emerging hazards like nanotechnology. New strategies which seek to eliminate not only the causes of work-related injury and illness, but also more broadly, worker injury and illness, are on the horizon. JF - Industrial Health AU - Howard, J AU - Hearl, F AD - National Institute for Occupational Safety and Health, Conters for Disease Control and Prevention, U.S. Department of Health and Human Services, 395 E Street, S.W., Suite 9200, Washington DC, USA, zkz1@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 80 EP - 83 VL - 50 IS - 2 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - USA KW - Injuries KW - police KW - Occupational safety KW - Compliance KW - Police KW - Legislation KW - nanotechnology KW - Nanotechnology KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014105073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Occupational+Safety+and+Health+in+the+USA%3A+Now+and+the+Future&rft.au=Howard%2C+J%3BHearl%2C+F&rft.aulast=Howard&rft.aufirst=J&rft.date=2012-03-01&rft.volume=50&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Mortality; police; Injuries; Compliance; Occupational safety; Police; Legislation; Nanotechnology; nanotechnology; USA ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF KAVA KAVA EXTRACT (CAS No. 9000-38-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 1011479278; 22441424 AB - Kava kava products are extracts from the root of the tropical shrub Piper methysticum. It was originally used for ceremonial beverages in the South Pacific and currently is used as an herbal product as an alternative to anti-anxiety drugs. We studied the effects of kava kava extract on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing kava kava extract in corn oil through a tube directly into the stomachs of 50 male and female rats and mice per dose group 5 days per week for 2 years. Exposed rats received either 0.1, 0.3 or 1 gram of kava kava extract per kilogram of body weight and mice received 0.25, 0.5, or 1 g/kg. Control animals received corn oil with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. There was a notable increase in uncommon malignant liver cancers (hepatoblastomas) in male mice and in hepatocellular carcinomas in female mice. In male rats receiving kava kava extract there was a slight increase in common testicular tumors. Other non-cancerous lesions that occurred in exposed animals were hepatocyte hypertrophy of the liver in male and female rats and mice and forestomach inflammation in male and female rats and female mice. We conclude that kava kava extract caused cancers of the liver in male and female mice. Increased incidences of testicular tumors in male rats might have been related to kava kava exposure. Kava kava also caused increased incidences of lesions in the liver, forestomach, kidney, eye, and pancreas of male and female rats, in the liver of male and female mice, and in the forestomach of female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 1 EP - 186 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Plant Extracts KW - gamma-Glutamyltransferase KW - Beverages KW - Herbal medicine KW - Liver cancer KW - Toxicology KW - Animals KW - Liver -- enzymology KW - Liver -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - gamma-Glutamyltransferase -- metabolism KW - Mice KW - Rats KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Liver -- drug effects KW - Neoplasms, Experimental -- chemically induced KW - Carcinogenicity Tests KW - Female KW - Male KW - Organ Size -- drug effects KW - Plant Extracts -- toxicity KW - Kava -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+KAVA+KAVA+EXTRACT+%28CAS+No.+9000-38-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=571&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Document feature - Illustrations; References; Tables; Diagrams N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1011479276 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=571&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1011479275 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BAndrews%2C+Ronnee+N%3BKashon%2C+Michael+L%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2012-01-27&rft.volume=&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.title=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.10.021 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - A Consensus Method for Updating Psychosocial Measures Used in NIOSH Health Hazard Evaluations AN - 1008846064; 16507828 AB - Objective: An expert panel was convened to select practical, valid psychosocial measures for use during National Institute for Occupational Safety and Health field investigations. Methods: A taxonomy of psychosocial constructs was developed using existing taxonomies and criteria regarding the malleability, actionability, and validity of constructs. Panel members identified measures for each construct based on their expertise and experience. Measures were selected on the basis of the following criteria: practicality, brevity, validity, availability of existing data, and lack of confounds between psychosocial constructs and outcomes. Results: The panel came to a consensus in recommending 24 measures representing 22 constructs. Conclusions: It is important that the National Institute for Occupational Safety and Health regularly evaluates its methodologies to ensure it is in line with current best practices. The measures identified will be used modularly in the National Institute for Occupational Safety and Health fieldwork depending on the nature of the evaluation request, industry type, and worker population. JF - Journal of Occupational and Environmental Medicine AU - Wiegand, D M AU - Chen, P Y AU - Hurrell, JJ Jr AU - Jex, S AU - Nakata, A AU - Nigam, JA AU - Robertson, M AU - Tetrick, LE AD - NIOSH/DSHEFS/HETAB, 4676 Columbia Parkway (MS R-10), Cincinnati, OH 45226, USA, dwiegand@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 350 EP - 355 VL - 54 IS - 3 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Hazards KW - best practices KW - Fieldwork KW - Best practices KW - Occupational safety KW - Taxonomy KW - taxonomy KW - fieldwork KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008846064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Cytokines+and+Inflammation+Conference&rft.atitle=Expression+Profiles+of+Human+Interferon-alpha+and+Interferon-lambda+Subtypes+Are+Ligand-+and+Cell-+Dependent&rft.au=Rabin%2C+Ronald&rft.aulast=Rabin&rft.aufirst=Ronald&rft.date=2012-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Hazards; best practices; Fieldwork; Best practices; Occupational safety; Taxonomy; fieldwork; taxonomy DO - http://dx.doi.org/10.1097/JOM.0b013e3182440a04 ER - TY - JOUR T1 - An analysis of reservoir conditions and responses in longwall panel overburden during mining and its effect on gob gas well performance AN - 1520102583; 2014-027609 AB - NIOSH conducted a cooperative research study to provide direct measurements of changing reservoir conditions in longwall panel overburden. The field measurements documented changes in permeabilities, methane concentrations, fluid pressures, and the effects of adjacent gob gas ventholes (GGVs) on NIOSH boreholes drilled in the study panel. Three different stratigraphic horizons were monitored by the NIOSH boreholes. Results indicated that the gob gas venthole fracture network formed 24 to 46m (80 to 150ft) ahead of the mining face. Overburden permeabilities within the same overburden test zones were approximately 1md prior to undermining, increasing to hundreds or thousands of md during undermining. Permeabilities measured seven months after undermining showed additional increases. The relationship between changing reservoir conditions, longwall face position, and surface movement is discussed. Recommendations are made to optimize GGV performance by evaluating changes in subsidence produced by mining, resulting in rock stresses that substantially influence induced fracture permeability. Mechanisms to account for the observed changes in reservoir conditions are reported. Abstract Copyright (2012) Elsevier, B.V. JF - Engineering Geology AU - Schatzel, Steven J AU - Karacan, C Ozgen AU - Dougherty, Heather AU - Goodman, Gerrit V R Y1 - 2012/02/24/ PY - 2012 DA - 2012 Feb 24 SP - 65 EP - 74 PB - Elsevier, Amsterdam VL - 127 SN - 0013-7952, 0013-7952 KW - mining KW - overburden KW - monitoring KW - methane KW - underground mining KW - explosions KW - aliphatic hydrocarbons KW - subsidence KW - alkanes KW - reservoir rocks KW - gases KW - ventilation KW - water pressure KW - organic compounds KW - longwall mining KW - hydraulic head KW - boreholes KW - fluid pressure KW - hydrocarbons KW - reservoir properties KW - vents KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520102583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Engineering+Geology&rft.atitle=An+analysis+of+reservoir+conditions+and+responses+in+longwall+panel+overburden+during+mining+and+its+effect+on+gob+gas+well+performance&rft.au=Schatzel%2C+Steven+J%3BKaracan%2C+C+Ozgen%3BDougherty%2C+Heather%3BGoodman%2C+Gerrit+V+R&rft.aulast=Schatzel&rft.aufirst=Steven&rft.date=2012-02-24&rft.volume=127&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Engineering+Geology&rft.issn=00137952&rft_id=info:doi/10.1016%2Fj.enggeo.2012.01.002 L2 - http://www.sciencedirect.com/science/journal/00137952 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2014-01-01 N1 - Number of references - 25 N1 - Document feature - illus. N1 - Last updated - 2014-05-01 N1 - CODEN - EGGOAO N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; boreholes; explosions; fluid pressure; gases; hydraulic head; hydrocarbons; longwall mining; methane; mining; monitoring; organic compounds; overburden; permeability; reservoir properties; reservoir rocks; subsidence; underground mining; ventilation; vents; water pressure DO - http://dx.doi.org/10.1016/j.enggeo.2012.01.002 ER - TY - CPAPER T1 - Facilitating Data Sharing to Enhance Drug Effectiveness and Safety T2 - 2012 Keystone Symposia Meeting on Complex Traits: Genomics and Computational Approaches AN - 1326135401; 6207544 JF - 2012 Keystone Symposia Meeting on Complex Traits: Genomics and Computational Approaches AU - Seyfert-Margolis, Vicki Y1 - 2012/02/20/ PY - 2012 DA - 2012 Feb 20 KW - Drugs KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.atitle=Facilitating+Data+Sharing+to+Enhance+Drug+Effectiveness+and+Safety&rft.au=Seyfert-Margolis%2C+Vicki&rft.aulast=Seyfert-Margolis&rft.aufirst=Vicki&rft.date=2012-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/index.cfm?e=Web.Meeting.Program&MeetingID=1153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - JOUR T1 - Genotoxicity of furan in Big Blue rats. AN - 918033529; 22200623 AB - Furan is a multispecies liver carcinogen whose cancer mode of action (MOA) is unclear. A major metabolite of furan is a direct acting mutagen; however, it is not known if genotoxicity is a key step in the tumors that result from exposure to furan. In order to address this question, transgenic Big Blue rats were treated by gavage five times a week for 8 weeks with two concentrations of furan used in cancer bioassays (2 and 8mg/kg), and with two higher concentrations (16 and 30mg/kg). Peripheral blood samples taken 24h after the 5th dose (1 week of dosing) were used to assay for micronucleus (MN) frequency in normochromatic erythrocytes (NCEs) and reticulocytes (RETs), and Pig-a gene mutation in total red blood cells (RBCs). 24h after the last dose of the 8-week treatment schedule, the rats were euthanized, and their tissues were used to perform NCE and RET MN assays, the Pig-a RBC assay, Pig-a and Hprt lymphocyte gene mutation assays, the liver cII transgene mutation assay, and the liver Comet assay. The responses in the MN assays conducted at both sampling times, and all the gene mutation assays, were uniformly negative; however, the Comet assay was positive for the induction of liver DNA damage. As the positive responses in the Comet assay were seen only with doses in excess of the cancer bioassay doses, and at least one of these doses (30mg/kg) produced toxicity in the liver, the overall findings from the study are consistent with furan having a predominantly nongenotoxic MOA for cancer. Published by Elsevier B.V. JF - Mutation research AU - McDaniel, L Patrice AU - Ding, Wei AU - Dobrovolsky, Vasily N AU - Shaddock, Joseph G AU - Mittelstaedt, Roberta A AU - Doerge, Daniel R AU - Heflich, Robert H AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02/18/ PY - 2012 DA - 2012 Feb 18 SP - 72 EP - 78 VL - 742 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Furans KW - 0 KW - Mutagens KW - furan KW - UC0XV6A8N9 KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Drug Administration Schedule KW - Animals, Genetically Modified KW - Male KW - Furans -- toxicity KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918033529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Genotoxicity+of+furan+in+Big+Blue+rats.&rft.au=McDaniel%2C+L+Patrice%3BDing%2C+Wei%3BDobrovolsky%2C+Vasily+N%3BShaddock%2C+Joseph+G%3BMittelstaedt%2C+Roberta+A%3BDoerge%2C+Daniel+R%3BHeflich%2C+Robert+H&rft.aulast=McDaniel&rft.aufirst=L&rft.date=2012-02-18&rft.volume=742&rft.issue=1-2&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-03 N1 - Date created - 2012-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2011.12.011 ER - TY - CPAPER T1 - Age and Sex Differences in Liver miRNA Expression During the Rat Life Cycle T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326136859; 6206129 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Kwekel, Joshua AU - Desai, Varsha AU - Han, Tao AU - Branham, William S AU - Moland, Carrie AU - Fuscoe, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Life cycle KW - Liver KW - Age KW - miRNA KW - Sex differences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326136859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Age+and+Sex+Differences+in+Liver+miRNA+Expression+During+the+Rat+Life+Cycle&rft.au=Kwekel%2C+Joshua%3BDesai%2C+Varsha%3BHan%2C+Tao%3BBranham%2C+William+S%3BMoland%2C+Carrie%3BFuscoe%2C+James&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - In silico Drug Repositioning Through Integrating Chemical, Biological and Clinical Properties T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326135638; 6206096 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Liu, Zhichao AU - Ding, Don AU - Reagan, Kelly AU - Fang, Hong AU - Tong, Weida Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=In+silico+Drug+Repositioning+Through+Integrating+Chemical%2C+Biological+and+Clinical+Properties&rft.au=Liu%2C+Zhichao%3BDing%2C+Don%3BReagan%2C+Kelly%3BFang%2C+Hong%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Knowledge Expansion, Network Modeling and Visualizations in Genomics and Proteomics T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326135593; 6206119 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Fang, Hong AU - Ding, Don AU - Ding, Yijun AU - Chen, Minjun AU - Liu, Zhichao AU - Xu, Xiaowei AU - Tong, Weida Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - proteomics KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Knowledge+Expansion%2C+Network+Modeling+and+Visualizations+in+Genomics+and+Proteomics&rft.au=Fang%2C+Hong%3BDing%2C+Don%3BDing%2C+Yijun%3BChen%2C+Minjun%3BLiu%2C+Zhichao%3BXu%2C+Xiaowei%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Data Mining for Identification of Bicluster Regions of HighDimensional T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326134481; 6206109 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Chen, Hung-Chia AU - Zou, Wen AU - Chen, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Mining KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326134481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Data+Mining+for+Identification+of+Bicluster+Regions+of+HighDimensional&rft.au=Chen%2C+Hung-Chia%3BZou%2C+Wen%3BChen%2C+James&rft.aulast=Chen&rft.aufirst=Hung-Chia&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Integration of ERCC probes into custom-designed DNA microarrays T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326134171; 6206121 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Han, Tao AU - Moland, Carrie AU - Branham, William AU - Desai, Varsha AU - Fuscoe, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Probes KW - DNA microarrays KW - Integration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326134171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Integration+of+ERCC+probes+into+custom-designed+DNA+microarrays&rft.au=Han%2C+Tao%3BMoland%2C+Carrie%3BBranham%2C+William%3BDesai%2C+Varsha%3BFuscoe%2C+James&rft.aulast=Han&rft.aufirst=Tao&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.title=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - GEN T1 - Nearly Half of College Student Treatment Admissions Were for Primary Alcohol Abuse. Data Spotlight AN - 968113421; ED529254 AB - Many students, and the public in general, believe that drinking alcohol is a normal part of the college experience. Unfortunately, students' efforts to "be sociable" or "fit in" can escalate into substance use behavior that puts their health and well-being at risk: One in four full-time college students have experienced past year alcohol abuse or dependence. In 2009, there were approximately 374,000 substance abuse treatment admissions aged 18 to 24. Nearly 12,000 of these admissions were college or other postsecondary school students. College student admissions were more likely than nonstudent admissions to report alcohol (46.6 vs. 30.6 percent) as their primary substance of abuse. College student and nonstudent admissions were equally likely to report marijuana as their primary substance of abuse (30.9 vs. 30.0 percent), and college student admissions were less likely than nonstudent admissions to report heroin (7.2 vs. 16.1 percent), other opiates (8.3 vs. 10.5 percent), cocaine (1.9 vs. 4.2 percent), or methamphetamine (1.0 vs. 4.4 percent) as their primary substance of abuse. (Contains 3 footnotes.) Y1 - 2012/02/07/ PY - 2012 DA - 2012 Feb 07 SP - 1 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Higher Education KW - Drinking KW - Substance Abuse KW - Counseling Services KW - Marijuana KW - Health Services KW - Risk KW - Alcohol Abuse KW - Student Attitudes KW - Help Seeking KW - Alcoholism KW - Health Behavior KW - College Students KW - Cocaine KW - Drug Rehabilitation KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968113421?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Isolation and structural characterization of two tadalafil analogs found in dietary supplements AN - 1837329145; 16092376 AB - During routine screenings of two "libido enhancer" dietary supplements using LC-MS super(n, two compounds were detected that displayed structural similarities to tadalafil. These compounds were isolated from the supplements using high-performance liquid chromatography with fraction collection, and were characterized further using accurate mass determination and NMR. "Compound 1" had an m/z of 434 for the [M+H]) super(+) ion, with a corresponding chemical formula of C sub(24H) sub(2)4N sub(3O) sub(5). "Compound 2" had an m/z of 432 for the [M+H] super(+ ion, with a corresponding chemical formula of C) sub(2)5H sub(26N) sub(3)O sub(4. Although mass spectrometry indicated that these modifications occurred in place of the -CH) sub(3) found on the pyrazinopyridoindole-1,4-dione of tadalafil, NMR was required to elucidate the correct configurations of these substitutions. The data obtained using NMR indicated that the structure of the -C sub(3H) sub(7)O moiety found in Compound 1 was 2-hydroxypropyl, and the -C sub(4H) sub(9) in Compound 2 was n-butyl. These new analogs were given the names 2-hydroxypropylnortadalafil and n-butylnortadalafil, respectively. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Toomey, Valerie M AU - Litzau, Jonathan J AU - Flurer, Cheryl L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA, cheryl.flurer@fda.hhs.gov Y1 - 2012/02/05/ PY - 2012 DA - 2012 Feb 05 SP - 50 EP - 57 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 59 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Tadalafil analog KW - PDE-5 inhibitors KW - Dietary supplement KW - LC-MS KW - NMR KW - High-performance liquid chromatography KW - Data processing KW - Dietary supplements KW - N.M.R. KW - Mass spectroscopy KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837329145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Isolation+and+structural+characterization+of+two+tadalafil+analogs+found+in+dietary+supplements&rft.au=Toomey%2C+Valerie+M%3BLitzau%2C+Jonathan+J%3BFlurer%2C+Cheryl+L&rft.aulast=Toomey&rft.aufirst=Valerie&rft.date=2012-02-05&rft.volume=59&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2011.09.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Data processing; Dietary supplements; N.M.R.; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.jpba.2011.09.038 ER - TY - CPAPER T1 - A mathematical framework for including various sources of variability in a task-based assessment of digital breast tomosynthesis T2 - 2012 Conference on Physics of Medical Imaging AN - 1313095324; 6147831 JF - 2012 Conference on Physics of Medical Imaging AU - Park, Subok AU - Badal-Soler, Andreu AU - Young, Stefano AU - Myers, Kyle Y1 - 2012/02/04/ PY - 2012 DA - 2012 Feb 04 KW - Medical imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313095324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=A+mathematical+framework+for+including+various+sources+of+variability+in+a+task-based+assessment+of+digital+breast+tomosynthesis&rft.au=Park%2C+Subok%3BBadal-Soler%2C+Andreu%3BYoung%2C+Stefano%3BMyers%2C+Kyle&rft.aulast=Park&rft.aufirst=Subok&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/documents/conferencesexhibitions/MI12-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Spatio-temporal Monte Carlo modeling of a-Se detectors for breast imaging: energy-weighted Swank noise and detective quantum efficiency T2 - 2012 Conference on Physics of Medical Imaging AN - 1313087449; 6147867 JF - 2012 Conference on Physics of Medical Imaging AU - Fang, Yuan AU - Badal-Soler, Andreu AU - Karim, Karim AU - Badano, Aldo Y1 - 2012/02/04/ PY - 2012 DA - 2012 Feb 04 KW - Monte Carlo simulation KW - Noise levels KW - Imaging techniques KW - Statistical analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313087449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=Spatio-temporal+Monte+Carlo+modeling+of+a-Se+detectors+for+breast+imaging%3A+energy-weighted+Swank+noise+and+detective+quantum+efficiency&rft.au=Fang%2C+Yuan%3BBadal-Soler%2C+Andreu%3BKarim%2C+Karim%3BBadano%2C+Aldo&rft.aulast=Fang&rft.aufirst=Yuan&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/documents/conferencesexhibitions/MI12-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Preparation, certification and interlaboratory analysis of workplace air filters spiked with high-fired beryllium oxide AN - 968184977; 16507500 AB - Occupational sampling and analysis for multiple elements is generally approached using various approved methods from authoritative government sources such as the National Institute for Occupational Safety and Health (NIOSH), the Occupational Safety and Health Administration (OSHA) and the Environmental Protection Agency (EPA), as well as consensus standards bodies such as ASTM International. The constituents of a sample can exist as unidentified compounds requiring sample preparation to be chosen appropriately, as in the case of beryllium in the form of beryllium oxide (BeO). An interlaboratory study was performed to collect analytical data from volunteer laboratories to examine the effectiveness of methods currently in use for preparation and analysis of samples containing calcined BeO powder. NIST SRM registered 1877 high-fired BeO powder (1100 to 1200 degree C calcining temperature; count median primary particle diameter 0.12 mu m) was used to spike air filter media as a representative form of beryllium particulate matter present in workplace sampling that is known to be resistant to dissolution. The BeO powder standard reference material was gravimetrically prepared in a suspension and deposited onto 37 mm mixed cellulose ester air filters at five different levels between 0.5 mu g and 25 mu g of Be (as BeO). Sample sets consisting of five BeO-spiked filters (in duplicate) and two blank filters, for a total of twelve unique air filter samples per set, were submitted as blind samples to each of 27 participating laboratories. Participants were instructed to follow their current process for sample preparation and utilize their normal analytical methods for processing samples containing substances of this nature. Laboratories using more than one sample preparation and analysis method were provided with more than one sample set. Results from 34 data sets ultimately received from the 27 volunteer laboratories were subjected to applicable statistical analyses. The observed performance data show that sample preparations using nitric acid alone, or combinations of nitric and hydrochloric acids, are not effective for complete extraction of Be from the SRM 1877 refractory BeO particulate matter spiked on air filters; but that effective recovery can be achieved by using sample preparation procedures utilizing either sulfuric or hydrofluoric acid, or by using methodologies involving ammonium bifluoride with heating. Laboratories responsible for quantitative determination of Be in workplace samples that may contain high-fired BeO should use quality assurance schemes that include BeO-spiked sampling media, rather than solely media spiked with soluble Be compounds, and should ensure that methods capable of quantitative digestion of Be from the actual material present are used. JF - Journal of Environmental Monitoring AU - Oatts, T J AU - Hicks, CE AU - Adams, A R AU - Brisson, MJ AU - Youmans-McDonald, L D AU - Hoover, MD AU - Ashley, K AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, 45226, USA, KAshley@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 391 EP - 401 VL - 14 IS - 2 SN - 1464-0325, 1464-0325 KW - Health & Safety Science Abstracts; Environment Abstracts; Sustainability Science Abstracts; Pollution Abstracts KW - Filters KW - Pollutant removal KW - EPA KW - Air purification KW - Beryllium KW - Occupational safety KW - Temperature KW - Particulates KW - International standardization KW - M3 1010:Issues in Sustainable Development KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968184977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Preparation%2C+certification+and+interlaboratory+analysis+of+workplace+air+filters+spiked+with+high-fired+beryllium+oxide&rft.au=Oatts%2C+T+J%3BHicks%2C+CE%3BAdams%2C+A+R%3BBrisson%2C+MJ%3BYoumans-McDonald%2C+L+D%3BHoover%2C+MD%3BAshley%2C+K&rft.aulast=Oatts&rft.aufirst=T&rft.date=2012-02-01&rft.volume=14&rft.issue=2&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1016%2Fj.combustflame.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Filters; EPA; Pollutant removal; Air purification; Occupational safety; Beryllium; Temperature; Particulates; International standardization DO - http://dx.doi.org/10.1039/c1em10688k ER - TY - JOUR T1 - Occupational Health and Safety Surveillance and Research Using Workers' Compensation Data AN - 968166960; 16435505 AB - Objective: Examine uses of US workers' compensation (WC) data for occupational safety and health purposes. Methods: This article is a summary of the proceedings from an invitational workshop held in September 2009 to discuss the use of WC data for occupational safety and health prevention purposes. Results: Workers' compensation data systems, although limited in many ways, contain information such as medical treatments, their costs and outcomes, and disability causes that are unavailable from national occupational surveillance sources. Conclusions: Despite their limitations, WC records are collected in a manner consistent with many occupational health and safety surveillance needs. Reports are available on the use of WC data for surveillance and research purposes such as estimating the frequency, magnitude, severity, and cost of compensated injuries. Inconsistencies in WC data can limit generalization of research results. JF - Journal of Occupational and Environmental Medicine AU - Utterback, D F AU - Schnorr, T M AU - Silverstein, BA AU - Spieler, E A AU - Leamon, T B AU - Amick, BC III AD - CDC/NIOSH, 4676 Columbia Parkway, R-12, Cincinnati, OH 45226, USA, dutterback@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 171 EP - 176 VL - 54 IS - 2 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - workers' compensation KW - disabilities KW - Injuries KW - Occupational safety KW - prevention KW - Medical treatment KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968166960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Health+and+Safety+Surveillance+and+Research+Using+Workers%27+Compensation+Data&rft.au=Utterback%2C+D+F%3BSchnorr%2C+T+M%3BSilverstein%2C+BA%3BSpieler%2C+E+A%3BLeamon%2C+T+B%3BAmick%2C+BC+III&rft.aulast=Utterback&rft.aufirst=D&rft.date=2012-02-01&rft.volume=54&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823c14cb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - workers' compensation; Injuries; disabilities; Occupational safety; prevention; Medical treatment; Occupational health DO - http://dx.doi.org/10.1097/JOM.0b013e31823c14cb ER - TY - JOUR T1 - Occupational Gradients in Smoking Behavior and Exposure to Workplace Environmental Tobacco Smoke The Multi-Ethnic Study of Atherosclerosis AN - 968166854; 16435501 AB - Objective: This study examines associations of occupation with smoking status, amount smoked among current and former smokers (number of cigarettes per day and lifetime cigarette consumption (pack-years)), and workplace exposure to environmental tobacco smoke (ETS) independent from income and education. Methods: This is a cross-sectional analysis of data from a community sample (n = 6355, age range: 45-84) using logistic and multinomial regression. All analyses were stratified by sex and adjusted for socio-demographic variables. Results: Male blue-collar and sales/office workers had higher odds of having consumed more than 20 pack-years of cigarettes than managers/professionals. For both male and female current or former smokers, exposure to workplace ETS was consistently and strongly associated with heavy smoking and greater pack-years. Conclusions: Blue-collar workplaces are associated with intense smoking and ETS exposure. Smoking must be addressed at both the individual and workplace levels especially in blue-collar workplaces. JF - Journal of Occupational and Environmental Medicine AU - Fujishiro, K AU - Stukovsky, KDH AU - Roux, AD AU - Landsbergis, P AU - Burchfiel, C AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy (R-15), Cincinnati, OH 45226, USA, kfujishiro@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 136 EP - 145 VL - 54 IS - 2 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Age KW - Behavior KW - Cigarettes KW - Education KW - Occupational exposure KW - Passive smoking KW - income KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968166854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Gradients+in+Smoking+Behavior+and+Exposure+to+Workplace+Environmental+Tobacco+Smoke+The+Multi-Ethnic+Study+of+Atherosclerosis&rft.au=Troy%2C+Tevi&rft.aulast=Troy&rft.aufirst=Tevi&rft.date=2012-02-01&rft.volume=133&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Commentary&rft.issn=00102601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Age; Education; Passive smoking; Behavior; Cigarettes; income; Occupational exposure DO - http://dx.doi.org/10.1097/JOM.0b013e318244501e ER - TY - JOUR T1 - Cronobacter spp. (previously Enterobacter sakazakii) invade and translocate across both cultured human intestinal epithelial cells and human brain microvascular endothelial cells AN - 968154229; 16164651 AB - The mechanism of Cronobacter pathogenesis in neonatal meningitis and potential virulence factors (aside from host cell invasion ability) remain largely unknown. To ascertain whether Cronobacter can invade and transcytose across intestinal epithelial cells, enter into the blood stream and then transcytose across the blood-brain-barrier, we have utilized human intestinal INT407 and Caco-2 cells and brain microvascular endothelial cell (HBMEC) monolayers on Transwell filters as experimental model systems. Our data indicate a wide range of heterogeneity with respect to invasion efficiency among twenty-three Cronobacter isolates screened. For selected isolates, we observed significant levels of transcytosis for Cronobacter sakazakii across tight monolayers of both Caco-2 and HBMEC, mimicking in vivo ability to cross the intestine as well as the blood brain barrier, and at a frequency equivalent to that of a control meningitis-causing Escherichia coli K1 strain. Finally, EM analysis demonstrated intracellular Cronobacter bacteria within host vacuoles in HBMEC, as well as transcytosed bacteria at the basolateral surface. These data reveal that certain Cronobacter isolates can invade and translocate across both cultured human intestinal epithelial cells and HBMEC, thus demonstrating a potential path for neonatal infections of the central nervous system (CNS) following oral ingestion. JF - Microbial Pathogenesis AU - Giri, Chandrakant P AU - Shima, Kensuke AU - Tall, Ben D AU - Curtis, Sherill AU - Sathyamoorthy, Venugopal AU - Hanisch, Brock AU - Kim, Kwang S AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, DBPAP, OVRR, Center for Biologics Evaluation and Research, Food & Drug Administration, Bethesda, MD 20892, USA, chandrakant.giri@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 140 EP - 147 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 52 IS - 2 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Blood KW - Blood-brain barrier KW - Brain KW - Central nervous system KW - Data processing KW - Endothelial cells KW - Epithelial cells KW - Filters KW - Infection KW - Intestine KW - Meningitis KW - Microvasculature KW - Mimicry KW - Neonates KW - Vacuoles KW - virulence factors KW - Enterobacter sakazakii KW - Escherichia coli KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968154229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Cronobacter+spp.+%28previously+Enterobacter+sakazakii%29+invade+and+translocate+across+both+cultured+human+intestinal+epithelial+cells+and+human+brain+microvascular+endothelial+cells&rft.au=Giri%2C+Chandrakant+P%3BShima%2C+Kensuke%3BTall%2C+Ben+D%3BCurtis%2C+Sherill%3BSathyamoorthy%2C+Venugopal%3BHanisch%2C+Brock%3BKim%2C+Kwang+S%3BKopecko%2C+Dennis+J&rft.aulast=Giri&rft.aufirst=Chandrakant&rft.date=2012-02-01&rft.volume=52&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2011.10.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Mimicry; Epithelial cells; Central nervous system; Microvasculature; Data processing; virulence factors; Blood-brain barrier; Brain; Infection; Meningitis; Filters; Endothelial cells; Blood; Vacuoles; Intestine; Neonates; Escherichia coli; Enterobacter sakazakii DO - http://dx.doi.org/10.1016/j.micpath.2011.10.003 ER - TY - JOUR T1 - Pulmonary Function and Left Ventricular Mass in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study AN - 923205085; 16304200 AB - Purpose: Impaired pulmonary function has been associated with increased cardiovascular disease incidence and mortality. The objective of this study was to investigate associations between pulmonary function and left ventricular (LV) mass. Methods: Participants were African American women (n = 1,069) and men (n = 555) aged 49-73 years, from the Atherosclerosis Risk in Communities study. Mean pulmonary function values at the first (1987-1989) and second (1990-1992) examinations were used. Echocardiograms were performed at the third and early in the fourth examinations (1993-1996). Analysis of covariance and linear regression were used to assess associations. Results: Mean levels of LV mass decreased with increasing quintiles of forced expiratory volume in one second (FEV1) among female never smokers (P = 0.039). Forced vital capacity (FVC) showed stronger associations than FEV1 with LV mass. Among men, LV mass was positively associated with FEV1 among current and never smokers, and with FVC among never smokers. Additional analyses among never smokers revealed significant inverse associations between LV mass and FVC among women with waist-to-hip ratios of >0.85 and those with no history of diabetes. In contrast, significant positive associations between LV mass and FVC were seen among male never smokers with body mass index (BMI) of less than or equal to 24.9 kg/m2, waist-to-hip ratios of less than or equal to 0.95, no history of hypertension or diabetes, and less than or equal to 60 years old. BMI and waist-to-hip ratio significantly modified associations among men. Conclusions: Among never smokers, LV mass and pulmonary function were inversely associated among women and positively associated among men. Further studies are warranted. (Echocardiography 2012; 29:131-139) JF - Echocardiography AU - Charles, Luenda E AU - Burchfiel, Cecil M AU - Andrew, Michael E AU - Gu, Ja K AU - Petrini, Marcy F AU - Butler, Jr Kenneth R AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 131 EP - 139 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 2 SN - 0742-2822, 0742-2822 KW - Biotechnology and Bioengineering Abstracts KW - Arteriosclerosis KW - Body mass index KW - Cardiovascular diseases KW - Diabetes mellitus KW - Echocardiography KW - Heart KW - Hypertension KW - Lung KW - Mortality KW - Ventricle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923205085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Echocardiography&rft.atitle=Pulmonary+Function+and+Left+Ventricular+Mass+in+African+Americans%3A+The+Atherosclerosis+Risk+in+Communities+%28ARIC%29+Study&rft.au=Charles%2C+Luenda+E%3BBurchfiel%2C+Cecil+M%3BAndrew%2C+Michael+E%3BGu%2C+Ja+K%3BPetrini%2C+Marcy+F%3BButler%2C+Jr+Kenneth+R&rft.aulast=Charles&rft.aufirst=Luenda&rft.date=2012-02-01&rft.volume=29&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Echocardiography&rft.issn=07422822&rft_id=info:doi/10.1111%2Fj.1540-8175.2011.01550.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Heart; Diabetes mellitus; Mortality; Ventricle; Lung; Echocardiography; Cardiovascular diseases; Arteriosclerosis; Body mass index; Hypertension DO - http://dx.doi.org/10.1111/j.1540-8175.2011.01550.x ER - TY - JOUR T1 - Continuing Medical Education Activity in Echocardiography AN - 923205075; 16304177 AB - Article Title: Pulmonary Function and Left Ventricular Mass in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study (Echocardiography 2012; 29:130) JF - Echocardiography AU - Fan, Pohoey AU - Charles, Luenda E AU - Burchfiel, Cecil M AU - Andrew, Michael E AU - Gu, Ja K AU - Petrini, Marcy F AU - Butler, Jr Kenneth R AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 130 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 2 SN - 0742-2822, 0742-2822 KW - Biotechnology and Bioengineering Abstracts KW - Arteriosclerosis KW - Echocardiography KW - Heart KW - Lung KW - Ventricle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923205075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Echocardiography&rft.atitle=Continuing+Medical+Education+Activity+in+Echocardiography&rft.au=Fan%2C+Pohoey%3BCharles%2C+Luenda+E%3BBurchfiel%2C+Cecil+M%3BAndrew%2C+Michael+E%3BGu%2C+Ja+K%3BPetrini%2C+Marcy+F%3BButler%2C+Jr+Kenneth+R&rft.aulast=Fan&rft.aufirst=Pohoey&rft.date=2012-02-01&rft.volume=29&rft.issue=2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Echocardiography&rft.issn=07422822&rft_id=info:doi/10.1111%2Fj.1540-8175.2011.01647.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Heart; Ventricle; Lung; Echocardiography; Arteriosclerosis DO - http://dx.doi.org/10.1111/j.1540-8175.2011.01647.x ER - TY - JOUR T1 - Work Experiences of Latina Immigrants: A Qualitative Study AN - 923201110; 16220723 AB - Almost half of the Latino immigrants working in the United States are women. However, studies concerning the work experiences of Latinas are almost absent in the literature. This article reports the findings from a qualitative study using eight focus groups (n = 53) of Latina immigrant workers. The focus group transcripts were analyzed using the grounded theory approach in which themes emerge from iterative readings of the transcripts by a group of investigators. This study identified themes related to excessive workload, familiar work/unfamiliar hazards, cultural tensions, lack of health care, pregnancy, sexual harassment, and family obligations/expectations. The responses of the Latina workers in this study clearly indicated that they live within a complex web of stressors, both as workers and as women. The increased economic opportunities that come with immigration to the United States are accompanied by many opportunities for exploitation, especially if they are undocumented. It is hoped that the findings of this study will raise awareness regarding these issues and spur further work in this area. JF - Journal of Career Development AU - Eggerth, Donald E AU - DeLaney, Sheli C AU - Flynn, Michael A AU - Jacobson, CJeff AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA  , deggerth@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 13 EP - 30 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 1 SN - 0894-8453, 0894-8453 KW - Sustainability Science Abstracts KW - Immigration KW - immigrants KW - sexual harassment KW - working conditions KW - careers KW - USA KW - Health care KW - Economics KW - Ethnic groups KW - culture KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923201110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Career+Development&rft.atitle=Work+Experiences+of+Latina+Immigrants%3A+A+Qualitative+Study&rft.au=Eggerth%2C+Donald+E%3BDeLaney%2C+Sheli+C%3BFlynn%2C+Michael+A%3BJacobson%2C+CJeff&rft.aulast=Eggerth&rft.aufirst=Donald&rft.date=2012-02-01&rft.volume=39&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Career+Development&rft.issn=08948453&rft_id=info:doi/10.1177%2F0894845311417130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - careers; Immigration; Health care; immigrants; sexual harassment; Economics; working conditions; culture; Ethnic groups; USA DO - http://dx.doi.org/10.1177/0894845311417130 ER - TY - JOUR T1 - Use of a common laboratory glassware detergent improves recovery of Cryptosporidium parvum and Cyclospora cayetanensis from lettuce, herbs and raspberries AN - 920804744; 16263200 AB - The success of any protocol designed to detect parasitic protozoa on produce must begin with an efficient initial wash step. Cryptosporidium parvum and Cyclospora cayetanensis oocysts were seeded onto herbs, lettuces and raspberries, eluted with one of four wash solutions and the recovered number of oocysts determined via fluorescent microscopy. Recovery rates for fluorescein thiosemicarbazide labeled C. parvum oocysts seeded onto spinach and raspberries and washed with de-ionized water were 38.4 +/- 10.1% and 34.9 +/- 6.2%, respectively. Two alternative wash solutions viz. 1 M glycine, pH 5.5 and a detachment solution were tested also using labeled C. parvum seeded spinach and raspberries. No statistically significant difference was noted in the recovery rates. However, a wash solution containing 0.1% Alconox registered , a laboratory glassware detergent, resulted in a significant improvement in oocyst recovery. 72.6 +/- 6.6% C. parvum oocysts were recovered from basil when washed with 0.1% Alconox registered compared to 47.9 +/- 5.8% using detachment solution. Also, C. cayetanensis oocysts were seeded onto lettuces, herbs and raspberries and the recovery using de-ionized water were compared to 0.1% Alconox registered wash: basil 17.5 +/- 5.0% to 76.1 +/- 14.0%, lollo rosso lettuce 38.3 +/- 5.5% to 72.5 +/- 8.1%, Tango leaf lettuce 45.9 +/- 5.4% to 71.1 +/- 7.8% and spring mix (mesclun) 39.8 +/- 0.7% to 80.2 +/- 11.3%, respectively. These results suggest that the use of Alconox registered in a wash solution significantly improves recovery resulting in the detection of these parasitic protozoa on high risk foods. JF - International Journal of Food Microbiology AU - Shields, Joan M AU - Lee, Michelle Minjung AU - Murphy, Helen R AD - Division of Virulence Assessment, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food & Drug Administration, United States, Joan.Shields@hhs.fda.gov Y1 - 2012/02/01/ PY - 2012 DA - 2012 Feb 01 SP - 123 EP - 128 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 153 IS - 1-2 SN - 0168-1605, 0168-1605 KW - Aqualine Abstracts; Water Resources Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cryptosporidium KW - Oocysts KW - Cryptosporidium parvum KW - AQ 00001:Water Resources and Supplies KW - K:03420 KW - A:01330 KW - SW 7060:Research facilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920804744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Use+of+a+common+laboratory+glassware+detergent+improves+recovery+of+Cryptosporidium+parvum+and+Cyclospora+cayetanensis+from+lettuce%2C+herbs+and+raspberries&rft.au=Shields%2C+Joan+M%3BLee%2C+Michelle+Minjung%3BMurphy%2C+Helen+R&rft.aulast=Shields&rft.aufirst=Joan&rft.date=2012-02-01&rft.volume=153&rft.issue=1-2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2011.10.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Oocysts; Cryptosporidium parvum DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2011.10.025 ER - TY - JOUR T1 - In vitro enrofloxacin binding in human fecal slurries. AN - 918576272; 22178170 AB - Most antibiotic inactivation studies have been conducted through in vitro incubations of human use aminoglycosides, beta-lactams, and fluoroquinolones, usually at fecal concentrations expected with therapeutic dose regimens in humans and animals. Less is known about the inactivation of these molecules when ingested at concentrations consistent with residue levels present in animal-derived foods from antibiotic treated animals. In this investigation, we used the fluoroquinolone, enrofloxacin which is specifically marketed for veterinary medicine as test compound. Fecal suspensions at 10%, 25%, and 50% (w/v) were subjected to physicochemical and molecular characterization and used in the drug binding studies. The fecal binding of enrofloxacin added at concentrations of 0.06, 0.1, 1, 5, 15, 50, and 150 mg/L was determined in various fecal slurry suspensions using analytical chemistry and microbiological assay methods. There was consistent correlation between both assay methods. By the analytical chemistry assay, the 10%, 25% and 50% diluted autoclaved fecal samples dosed with enrofloxacin showed binding of 50±4.6%, 54±6.5% and 56±6.8% of the enrofloxacin, respectively. Binding of enrofloxacin to fecal contents occurred rapidly within 10 min and remained constant over the incubation period. Denaturing gradient gel electrophoreses and pyrosequencing analysis showed varied profiles of the bacterial composition of the human intestinal microbiota for fecal samples from different individuals. This study provided information on methodological questions that have concerned regulatory authorities on in vitro testing to determine if concentrations of veterinary antimicrobial agent residues entering the human colon remain microbiologically active. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Ahn, Youngbeom AU - Linder, Sean W AU - Veach, Brian T AU - Steve Yan, S AU - Haydée Fernández, A AU - Pineiro, Silvia A AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 74 EP - 84 VL - 62 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Fluoroquinolones KW - RNA, Ribosomal, 16S KW - enrofloxacin KW - 3DX3XEK1BN KW - Index Medicus KW - Bacteria -- genetics KW - Denaturing Gradient Gel Electrophoresis KW - RNA, Ribosomal, 16S -- genetics KW - Humans KW - DNA, Bacterial -- genetics KW - Adsorption KW - Bacteria -- classification KW - Chromatography, High Pressure Liquid KW - Feces -- microbiology KW - Anti-Bacterial Agents -- metabolism KW - Anti-Bacterial Agents -- chemistry KW - Fluoroquinolones -- metabolism KW - Feces -- chemistry KW - Fluoroquinolones -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918576272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=In+vitro+enrofloxacin+binding+in+human+fecal+slurries.&rft.au=Ahn%2C+Youngbeom%3BLinder%2C+Sean+W%3BVeach%2C+Brian+T%3BSteve+Yan%2C+S%3BHayd%C3%A9e+Fern%C3%A1ndez%2C+A%3BPineiro%2C+Silvia+A%3BCerniglia%2C+Carl+E&rft.aulast=Ahn&rft.aufirst=Youngbeom&rft.date=2012-02-01&rft.volume=62&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.11.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-08 N1 - Date created - 2012-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.11.013 ER - TY - JOUR T1 - Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity. AN - 917577686; 22112502 AB - Circulating microRNAs (miRNAs) have emerged as novel noninvasive biomarkers for several diseases and other types of tissue injury. This study tested the hypothesis that changes in the levels of urinary miRNAs correlate with liver injury induced by hepatotoxicants. Sprague-Dawley rats were administered acetaminophen (APAP) or carbon tetrachloride (CCl(4)) and one nonhepatotoxicant (penicillin/PCN). Urine samples were collected over a 24 h period after a single oral dose of APAP (1250 mg/kg), CCl(4) (2000 mg/kg), or PCN (2400 mg/kg). APAP and CCl(4) induced liver injury based upon increased serum alanine and aspartate aminotransferase levels and histopathological findings, including liver necrosis. APAP and CCl(4) both significantly increased the urinary levels of 44 and 28 miRNAs, respectively. In addition, 10 of the increased miRNAs were in common between APAP and CCl(4). In contrast, PCN caused a slight decrease of a different nonoverlapping set of urinary miRNAs. Cluster analysis revealed a distinct urinary miRNA pattern from the hepatotoxicant-treated groups when compared with vehicle controls and PCN. Analysis of hepatic miRNA levels suggested that the liver was the source of the increased urinary miRNAs after APAP exposure; however, the results from CCl(4) were equivocal. Computational analysis was used to predict target genes of the 10 shared hepatotoxicant-induced miRNAs. Liver gene expression profiling using whole genome microarrays identified eight putative miRNA target genes that were significantly altered in the liver of APAP- and CCl(4)-treated animals. In conclusion, the patterns of urinary miRNA may hold promise as biomarkers of hepatotoxicant-induced liver injury. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Yang, Xi AU - Greenhaw, James AU - Shi, Qiang AU - Su, Zhenqiang AU - Qian, Feng AU - Davis, Kelly AU - Mendrick, Donna L AU - Salminen, William F AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 335 EP - 344 VL - 125 IS - 2 KW - Biomarkers KW - 0 KW - Genetic Markers KW - MicroRNAs KW - Penicillins KW - Acetaminophen KW - 362O9ITL9D KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Animals KW - Predictive Value of Tests KW - Alkaline Phosphatase -- blood KW - Risk Assessment KW - Rats KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Necrosis KW - Rats, Sprague-Dawley KW - Urinalysis KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Penicillins -- toxicity KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- urine KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- drug effects KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Chemical and Drug Induced Liver Injury -- genetics KW - Toxicity Tests -- methods KW - Liver -- metabolism KW - MicroRNAs -- urine KW - Carbon Tetrachloride -- toxicity KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917577686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Identification+of+urinary+microRNA+profiles+in+rats+that+may+diagnose+hepatotoxicity.&rft.au=Yang%2C+Xi%3BGreenhaw%2C+James%3BShi%2C+Qiang%3BSu%2C+Zhenqiang%3BQian%2C+Feng%3BDavis%2C+Kelly%3BMendrick%2C+Donna+L%3BSalminen%2C+William+F&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2012-02-01&rft.volume=125&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr321 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-17 N1 - Date created - 2012-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr321 ER - TY - JOUR T1 - Changes in mouse liver protein glutathionylation after acetaminophen exposure. AN - 917162967; 22045778 AB - The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300 mg/kg APAP in B6C3F1 mice produced increased serum alanine aminotransferase and aspartate aminotransferase levels and liver necrosis in a dose-dependent manner. The ratio of GSH to GSSG was decreased in a dose-dependent manner, suggesting that APAP produced a more oxidizing environment within the liver. Despite the increased oxidation state, the level of global protein glutathionylation was decreased at 1 h and continued to decline through 24 h. Immunohistochemical localization of glutathionylated proteins showed a complex dynamic change in the lobule zonation of glutathionylated proteins. At 1 h after APAP exposure, the level of glutathionylation decreased in the single layer of hepatocytes around the central veins but increased mildly in the remaining centrilobular hepatocytes. This increase correlated with the immunohistochemical localization of APAP covalently bound to protein. Thereafter, the level of glutathionylation decreased dramatically over time in the centrilobular regions with major decreases observed at 6 and 24 h. Despite the overall decreased glutathionylation, a layer of cells lying between the undamaged periportal region and the damaged centrilobular hepatocytes exhibited high levels of glutathionylation at 3 and 6 h in all samples and in some 24-h samples that had milder injury. These temporal and zonal pattern changes in protein glutathionylation after APAP exposure indicate that protein glutathionylation may play a role in protein homeostasis during APAP-induced hepatocellular injury. JF - The Journal of pharmacology and experimental therapeutics AU - Yang, Xi AU - Greenhaw, James AU - Ali, Akhtar AU - Shi, Qiang AU - Roberts, Dean W AU - Hinson, Jack A AU - Muskhelishvili, Levan AU - Beger, Richard AU - Pence, Lisa M AU - Ando, Yosuke AU - Sun, Jinchun AU - Davis, Kelly AU - Salminen, William F AD - Division of Systems Biology, Food and Drug Administration/National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 360 EP - 368 VL - 340 IS - 2 KW - Proteins KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - 3-(cystein-S-yl)paracetamol KW - 6Q2X58Y8BP KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Glutathione Disulfide KW - ULW86O013H KW - Index Medicus KW - Chemical and Drug Induced Liver Injury -- blood KW - Animals KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- pathology KW - Glutathione Disulfide -- metabolism KW - Necrosis -- pathology KW - Mice KW - Hepatocytes -- pathology KW - Necrosis -- metabolism KW - Necrosis -- blood KW - Mice, Inbred Strains KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Male KW - Hepatocytes -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - Acetaminophen -- administration & dosage KW - Liver -- pathology KW - Liver -- drug effects KW - Glutathione -- metabolism KW - Acetaminophen -- adverse effects KW - Liver -- metabolism KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- metabolism KW - Proteins -- metabolism KW - Acetaminophen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917162967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Changes+in+mouse+liver+protein+glutathionylation+after+acetaminophen+exposure.&rft.au=Yang%2C+Xi%3BGreenhaw%2C+James%3BAli%2C+Akhtar%3BShi%2C+Qiang%3BRoberts%2C+Dean+W%3BHinson%2C+Jack+A%3BMuskhelishvili%2C+Levan%3BBeger%2C+Richard%3BPence%2C+Lisa+M%3BAndo%2C+Yosuke%3BSun%2C+Jinchun%3BDavis%2C+Kelly%3BSalminen%2C+William+F&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2012-02-01&rft.volume=340&rft.issue=2&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.111.187948 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-06 N1 - Date created - 2012-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2001 Jan;31(1):55-138 [11215692] J Biol Chem. 2011 Mar 18;286(11):9298-307 [21216949] Toxicol Appl Pharmacol. 2002 Jun 1;181(2):133-41 [12051997] J Pharmacol Exp Ther. 2002 Nov;303(2):468-75 [12388625] Toxicol Sci. 2003 Oct;75(2):458-67 [12883092] Hepatology. 2004 May;39(5):1267-76 [15122755] J Pharmacol Exp Ther. 1983 Dec;227(3):749-54 [6655568] Mol Pharmacol. 1985 Sep;28(3):306-11 [4033631] J Biol Chem. 1989 Jun 15;264(17):9814-9 [2524496] Chem Biol Interact. 1989;70(3-4):241-8 [2743472] J Biol Chem. 1990 Feb 25;265(6):3059-65 [2303440] Biochem Pharmacol. 1990 Sep 15;40(6):1211-8 [2403376] J Pharmacol Exp Ther. 1990 Dec;255(3):935-41 [2262912] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] Drug Metab Dispos. 1990 Nov-Dec;18(6):882-7 [1981532] Biochem Pharmacol. 1993 Mar 24;45(6):1251-9 [8466546] Arch Biochem Biophys. 1996 Nov 1;335(1):61-72 [8914835] Toxicol Lett. 1997 Jan 15;90(1):77-82 [9020405] J Pharmacol Exp Ther. 1997 Sep;282(3):1533-40 [9316869] J Biol Chem. 2004 Nov 12;279(46):47939-51 [15347644] J Hepatol. 2005 Jan;42(1):110-6 [15629515] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):389-97 [16863451] Free Radic Biol Med. 2007 Sep 15;43(6):883-98 [17697933] J Biol Chem. 2007 Nov 9;282(45):32640-54 [17848555] Mol Interv. 2007 Dec;7(6):313-24 [18199853] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] J Nutr. 2008 Dec;138(12):2328-36 [19022953] Cancer Res. 2009 Oct 1;69(19):7626-34 [19773442] Handb Exp Pharmacol. 2010;(196):369-405 [20020268] J Biol Chem. 2010 May 28;285(22):17077-88 [20348099] Toxicol Sci. 2010 Jul;116(1):151-63 [20351055] Chem Res Toxicol. 2010 Jul 19;23(7):1286-92 [20578685] J Cell Biol. 2010 Aug 9;190(3):391-405 [20679432] J Biomed Sci. 2010;17 Suppl 1:S35 [20804611] Circulation. 2010 Dec 21;122(25):2699-708 [21135361] Biochem Pharmacol. 2001 Jan 15;61(2):245-52 [11163339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.111.187948 ER - TY - JOUR T1 - Transferability of a modified embryonic stem cell test using a new endpoint for developmental neurotoxicity. AN - 916522715; 22082211 AB - We developed and analyzed a new surrogate endpoint of the mouse embryonic stem cell test (EST) for developmental neurotoxicity. To determine the sensitivity, specificity, and transferability of the new endpoint, a pre-validation team from three independent laboratories optimized and standardized the protocol for neuronal differentiation of mouse embryonic stem cells (mESCs) by measuring the neuronal differentiation rates of mESCs under different culture conditions, such as the presence or absence of basic fibroblast growth factor (bFGF) in the growth media and varying lengths of culture. In addition, a component ratio of neuronal cells was measured by using flow cytometry analysis of β-III tubulin (Tuj1)-positive cells and real-time polymerase chain reaction analysis of microtubule-associated protein 2 (MAP2) mRNA. Our results showed that the best growth was achieved by culturing mESCs for 12 d in N2B27 medium without bFGF or ascorbic acid. Lead (II) acetate and aroclor 1254 were used to test the usefulness of the new endpoint. When we used the known ID(50) values for lead (II) acetate in the EST model, it was classified as non-embryotoxic; however, when we used the new ID(50) values that we determined in this study, it was classified as weakly embryotoxic. Aroclor 1254 and penicillin G were also classified as weakly embryotoxic and non-embryotoxic compounds, respectively, when cardiac and neuronal differentiation ID(50) values were used. Therefore, our new surrogate endpoint for developmental neurotoxicity is not only sensitive and specific but also transferable among laboratories. JF - Toxicology mechanisms and methods AU - Baek, Dae Hyun AU - An, Su-Yeon AU - Park, Jae Hyun AU - Choi, Youngju AU - Park, Ki Dae AU - Kang, Jin Wook AU - Choi, Kyoung Suk AU - Park, Sung Hee AU - Whang, Min Young AU - Han, Jiyou AU - Kim, Jong-Hoon AU - Kim, Hyung Soo AU - Geum, Dongho AU - Yoo, Tae Moo AD - National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration , Cheongwon-gun, Chungcheongbuk-do Republic of Korea. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 118 EP - 130 VL - 22 IS - 2 KW - Chlorodiphenyl (54% Chlorine) KW - 11097-69-1 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Animals KW - Chlorodiphenyl (54% Chlorine) -- toxicity KW - Lead -- toxicity KW - Dose-Response Relationship, Drug KW - Mice KW - Cell Differentiation -- drug effects KW - NIH 3T3 Cells KW - Embryonic Stem Cells -- drug effects KW - Neurons -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916522715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Transferability+of+a+modified+embryonic+stem+cell+test+using+a+new+endpoint+for+developmental+neurotoxicity.&rft.au=Baek%2C+Dae+Hyun%3BAn%2C+Su-Yeon%3BPark%2C+Jae+Hyun%3BChoi%2C+Youngju%3BPark%2C+Ki+Dae%3BKang%2C+Jin+Wook%3BChoi%2C+Kyoung+Suk%3BPark%2C+Sung+Hee%3BWhang%2C+Min+Young%3BHan%2C+Jiyou%3BKim%2C+Jong-Hoon%3BKim%2C+Hyung+Soo%3BGeum%2C+Dongho%3BYoo%2C+Tae+Moo&rft.aulast=Baek&rft.aufirst=Dae&rft.date=2012-02-01&rft.volume=22&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2011.603394 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-04 N1 - Date created - 2012-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/15376516.2011.603394 ER - TY - JOUR T1 - Alternative models in developmental toxicology. AN - 916151196; 22239077 AB - In light of various pressures, toxicologists have been searching for alternative methods for safety testing of chemicals. According to a recent policy in the European Union (Regulation, Evaluation Authorisation and Restriction of Chemicals, REACH), it has been estimated that over the next twelve to fifteen years, approximately 30,000 chemicals may need to be tested for safety, and under current guidelines such testing would require the use of approximately 7.2 million laboratory animals [ Hofer et al. 2004 ]. It has also been estimated that over 80% of all animals used for safety testing under REACH legislation would be used for examining reproductive and developmental toxicity [Hofer et al., 2004]. In addition to REACH initiatives, it has been estimated that out of 5,000 to 10,000 new drug entities that a pharmaceutical company may start with, only one is finally approved by the Food and Drug Administration at a cost of over one billion dollars [ Garg et al. 2011 ]. A large portion of this cost is due to animal testing. Therefore, both the pharmaceutical and chemical industries are interested in using alternative models and in vitro tests for safety testing. This review will examine the current state of three alternative models - whole embryo culture (WEC), the mouse embryonic stem cell test (mEST), and zebrafish. Each of these alternatives will be reviewed, and advantages and disadvantages of each model will be discussed. These models were chosen because they are the models most commonly used and would appear to have the greatest potential for future applications in developmental toxicity screening and testing. JF - Systems biology in reproductive medicine AU - Lee, Hyung-yul AU - Inselman, Amy L AU - Kanungo, Jyotshnabala AU - Hansen, Deborah K AD - Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 10 EP - 22 VL - 58 IS - 1 KW - Index Medicus KW - Rats KW - Animals KW - Embryonic Stem Cells -- drug effects KW - Humans KW - Mice KW - Embryonic Development -- drug effects KW - Zebrafish -- embryology KW - Cell Line KW - Risk Assessment KW - Embryo Culture Techniques KW - Models, Animal KW - Animal Testing Alternatives KW - Toxicity Tests -- methods KW - Developmental Biology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916151196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Systems+biology+in+reproductive+medicine&rft.atitle=Alternative+models+in+developmental+toxicology.&rft.au=Lee%2C+Hyung-yul%3BInselman%2C+Amy+L%3BKanungo%2C+Jyotshnabala%3BHansen%2C+Deborah+K&rft.aulast=Lee&rft.aufirst=Hyung-yul&rft.date=2012-02-01&rft.volume=58&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Systems+biology+in+reproductive+medicine&rft.issn=1939-6376&rft_id=info:doi/10.3109%2F19396368.2011.648302 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-16 N1 - Date created - 2012-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/19396368.2011.648302 ER - TY - JOUR T1 - Metabolomics data and the biomarker qualification process AN - 1709167485; 16369887 AB - Since its initial applications in healthcare research over a decade ago, metabolomics has matured into a technology that can now reliably detect and quantify hundreds of metabolites in biofluids and tissue samples. With substantial improvements in analytical capabilities in recent years, metabolomics now has the potential to provide sensitive and specific biomarkers of health and disease status, drug toxicity and therapeutic efficacy. Although many of the clinical biomarkers currently in use are metabolites such as glucose, cholesterol, and creatinine, few, if any, new metabolites (or panel of metabolites) derived from metabolomic analyses have been submitted to the FDA as biomarker candidates. Under a recent FDA draft Guidance for Industry from the Center for Drug Evaluation and Research (CDER), biomarkers discovered using metabolomics, like those derived from genetic, transcriptomic, and proteomic studies, may be submitted to CDER for consideration as new drug development tools and entered into a formal biomarker qualification process. The qualification process begins with a letter of intent from the submitter, followed by discussions with FDA and then the submission of data supporting the performance of the biomarker within a specific context of use. CDER forms a Biomarker Qualification Review Team at the start of the interactive process to advise the biomarker developer on the type of information important to support the proposed context of use, and review the data that evaluates the biomarker for the proposed context of use when the biomarker development appears complete and the full supporting data are submitted. Once qualified, a biomarker can be used in drug development within the qualified context of use without requesting additional regulatory review concerning its suitability. JF - Metabolomics AU - Beger, Richard D AU - Colatsky, Thomas AD - Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, Richard.Beger@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 2 EP - 7 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 8 IS - 1 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Glucose KW - Metabolites KW - Drug development KW - Toxicity KW - Cholesterol KW - biomarkers KW - Creatinine KW - Reviews KW - proteomics KW - Drugs KW - metabolomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709167485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolomics+data+and+the+biomarker+qualification+process&rft.au=Beger%2C+Richard+D%3BColatsky%2C+Thomas&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2012-02-01&rft.volume=8&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-011-0342-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Creatinine; Data processing; Reviews; Glucose; Drug development; Metabolites; Cholesterol; proteomics; Toxicity; Drugs; biomarkers; metabolomics DO - http://dx.doi.org/10.1007/s11306-011-0342-z ER - TY - JOUR T1 - Accelerating the Translation of Research into Practice in Long Term Services and Supports: A Critical Need for Federal Infrastructure at the Nexus of Aging and Disability AN - 1438554408; 201308202 AB - The nexus of aging and disability, characterized by the phenomenon of aging with a disability, will become more visible as the population ages and the number of people with disabilities surviving to midlife increases. This article addresses 3 interrelated issues critical to the fields of aging and disability: increasing demand for community-based long-term services and supports, a paucity of evidence-based programs demonstrating effectiveness in facilitating independence for those aging with a disability, and lack of a federal infrastructure to support coordinated investments in research-to-practice for this population. Suggestions for federal interagency collaborations are given, along with roles for key stakeholders. Adapted from the source document. JF - Journal of Gerontological Social Work AU - Washko, Michelle M AU - Campbell, Margaret AU - Tilly, Jane AD - Administration on Aging, U.S. Department of Health and Human Services, Washington, DC, USA michelle.washko@aoa.hhs.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 112 EP - 125 PB - Taylor & Francis, Philadelphia PA VL - 55 IS - 2 SN - 0163-4372, 0163-4372 KW - aging with disability research translation practice KW - Physically Handicapped KW - Aging KW - Evidence Based Practice KW - Interest Groups KW - Interorganizational Networks KW - Effectiveness KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438554408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gerontological+Social+Work&rft.atitle=Accelerating+the+Translation+of+Research+into+Practice+in+Long+Term+Services+and+Supports%3A+A+Critical+Need+for+Federal+Infrastructure+at+the+Nexus+of+Aging+and+Disability&rft.au=Washko%2C+Michelle+M%3BCampbell%2C+Margaret%3BTilly%2C+Jane&rft.aulast=Washko&rft.aufirst=Michelle&rft.date=2012-02-01&rft.volume=55&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gerontological+Social+Work&rft.issn=01634372&rft_id=info:doi/10.1080%2F01634372.2011.642471 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGSWDU N1 - SubjectsTermNotLitGenreText - Physically Handicapped; Aging; Interorganizational Networks; Interest Groups; Effectiveness; Evidence Based Practice DO - http://dx.doi.org/10.1080/01634372.2011.642471 ER - TY - GEN T1 - Enhanced Early Head Start with Employment Services: 42-Month Impacts from the Kansas and Missouri Sites of the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project. OPRE Report 2012-05 AN - 1314325796; ED539262 AB - MDRC is conducting the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project under a contract with the Administration for Children and Families (ACF) in the U.S. Department of Health and Human Services (HHS). As part of the multisite Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project, MDRC, together with its research partners, is leading an evaluation of parental employment and educational services delivered within Early Head Start (Enhanced EHS). The program model tested here aims to dually address the employment and educational needs of parents who are at risk of unemployment and the developmental needs of their children. The study is sponsored by the U.S. Department of Health and Human Services, with additional funding from the U.S. Department of Labor. The study uses a rigorous random assignment design comparing outcomes for families and children who were offered Enhanced EHS with outcomes for those who could only access alternative services in the community. This report presents the final impact results approximately 42 months after families and children first entered the study. Key findings include: (1) Because of implementation challenges, the Enhanced EHS program's formalized employment, educational, and self-sufficiency enhancements were never fully integrated into core EHS services; (2) At the 42-month follow-up, Enhanced EHS did not significantly affect parental employment and economic outcomes, parenting practices, or child development and well-being among the full research sample; and (3) Enhanced EHS generated positive impacts on parental employment and economic outcomes for families who were expecting a child or who had an infant (a child younger than 12 months old) when they first entered the study. The results illustrate the challenges of integrating enhancements aimed at addressing parents' education, employment, and self-sufficiency needs into a two-generational program that is focused primarily on goals related to parenting, family interactions, and child development. In the context of these implementation difficulties, Enhanced EHS had limited long-term impacts for the full sample. Yet Enhanced EHS had positive long-term impacts on parental employment and earnings for families who had an infant or who were expecting a child at the outset of the study. This suggests that the approach may be effective for some families. Appended are: (1) Response Bias Analysis: 42-Month Survey of Parents and Direct Child Assessments; (2) Impacts on Child Care; and (3) Impacts on Employment. Individual chapters contain tables, boxes and footnotes. AU - Hsueh, JoAnn AU - Farrell, Mary E. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 126 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Kansas KW - Missouri KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - At Risk Persons KW - Program Effectiveness KW - Employment Services KW - Young Children KW - Well Being KW - Unemployment KW - Socioeconomic Status KW - Employment Opportunities KW - Employed Parents KW - Educational Needs KW - At Risk Students KW - Demonstration Programs KW - Parenting Styles KW - Family Programs KW - Child Rearing KW - Welfare Recipients KW - Early Intervention KW - Disadvantaged Youth KW - Child Development KW - Family Income KW - Program Evaluation KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1314325796?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - New Federal Policy Initiatives To Boost Health Literacy Can Help The Nation Move Beyond The Cycle Of Costly 'Crisis Care' AN - 1151043736; 2011-300667 AB - Health literacy is the capacity to understand basic health information and make appropriate health decisions. Tens of millions of Americans have limited health literacy-a fact that poses major challenges for the delivery of high-quality care. Despite its importance, health literacy has until recently been relegated to the sidelines of health care improvement efforts aimed at increasing access, improving quality and better managing costs. Recent federal policy initiatives, including the Affordable Care Act of 2010, the Department of Health and Human Services' National Action Plan to Improve Health Literacy, and the Plain Writing Act of 2010, have brought health literacy to a tipping point-that is, poised to make the transition from the margins to the mainstream. If public and private organizations make it a priority to become health literate, the nation's health literacy can be advanced to the point at which it will play a major role in improving health care and health for all Americans. Adapted from the source document. JF - Health Affairs AU - Koh, Howard K AU - Berwick, Donald M AU - Clancy, Carolyn M AU - Baur, Cynthia AU - Brach, Cindy AU - Harris, Linda M AU - Zerhusen, Eileen G AD - Department of Health and Human Services (HHS), in Washington, D.C Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 434 EP - 443 PB - Project HOPE, Bethesda MD VL - 31 IS - 2 SN - 0278-2715, 0278-2715 KW - Education and education policy - Adult, technical, and vocational education KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Economic conditions and policy - Economic theory KW - Cost KW - United States KW - Health policy KW - Medical service KW - Literacy KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1151043736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=New+Federal+Policy+Initiatives+To+Boost+Health+Literacy+Can+Help+The+Nation+Move+Beyond+The+Cycle+Of+Costly+%27Crisis+Care%27&rft.au=Koh%2C+Howard+K%3BBerwick%2C+Donald+M%3BClancy%2C+Carolyn+M%3BBaur%2C+Cynthia%3BBrach%2C+Cindy%3BHarris%2C+Linda+M%3BZerhusen%2C+Eileen+G&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2012-02-01&rft.volume=31&rft.issue=2&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff%2C2011.1169 LA - English DB - PAIS Index N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Literacy; Medical service; United States; Health policy; Legislation; Cost DO - http://dx.doi.org/10.1377/hlthaff,2011.1169 ER - TY - JOUR T1 - Serosorting and sexual risk behaviour according to different casual partnership types among MSM: the study of one-night stands and sex buddies AN - 1081895287; 201225276 AB - Among HIV-negative men who have sex with men (MSM), any incident of unprotected anal intercourse (UAI) between casual partners is usually regarded as risky for HIV transmission. However, men are increasingly using knowledge of their casual partner's HIV-status to reduce HIV risk during UAI (i.e., serosorting). Since familiarity between casual partners may lead to higher levels of UAI and serosorting, we examined how often men have UAI and practice serosorting with three types of casual partnerships that differ in their degree of familiarity. We included 240 HIV-negative men of the Amsterdam Cohort Study among MSM. We distinguished three types of casual partnerships: one-night stand ("met by chance and had sex only once"); multiple-time casual partner ("met and had sex with several times") and the "regular" casual partner ("sex buddy"). Serosorting was defined as UAI with an HIV-concordant partner. Generalised estimating equations analyses were used to examine the association between type of casual partnership and sexual risk behaviour. Analyses revealed that men with a sex buddy were more likely to have UAI than men with a one-night stand (OR [95%CI] 2.39 [1.39-4.09]). However, men with a sex buddy were also more likely to practice serosorting than men with a one-night stand (OR [95%CI] 5.20 [1.20-22.52]). Men with a sex buddy had more UAI but also reported more serosorting than men with a one-night stand. As a result, the proportion of UAI without serosorting is lower for men with a sex buddy, and therefore men might have less UAI at risk for HIV with this partner type. However, the protective value of serosorting with a sex buddy against HIV transmission needs to be further established. At this time, we suggest that a distinction between the one-night stand and the sex buddy should be incorporated in future studies as men behave significantly different with the two partner types. Adapted from the source document. JF - AIDS Care AU - van den Boom, Wijnand AU - Stolte, Ineke AU - Sandfort, Theo AU - Davidovich, Udi AD - Department of Research, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 167 EP - 173 PB - Taylor & Francis, Abingdon UK VL - 24 IS - 2 SN - 0954-0121, 0954-0121 KW - men who have sex with men serosorting sexual behaviour risk reduction behaviour types of casual partnerships unprotected anal intercourse KW - Safe sexual practices KW - Men KW - Cohort analysis KW - Partnerships KW - Risk reduction KW - Familiarity KW - HIV KW - At risk KW - Homosexuals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Serosorting+and+sexual+risk+behaviour+according+to+different+casual+partnership+types+among+MSM%3A+the+study+of+one-night+stands+and+sex+buddies&rft.au=van+den+Boom%2C+Wijnand%3BStolte%2C+Ineke%3BSandfort%2C+Theo%3BDavidovich%2C+Udi&rft.aulast=van+den+Boom&rft.aufirst=Wijnand&rft.date=2012-02-01&rft.volume=24&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2011.603285 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AIDCEF N1 - SubjectsTermNotLitGenreText - Men; Partnerships; HIV; Homosexuals; Familiarity; Safe sexual practices; Cohort analysis; Risk reduction; At risk DO - http://dx.doi.org/10.1080/09540121.2011.603285 ER - TY - JOUR T1 - Obama Care at the Supreme Court: What will be at stake when the Justices hear the most controversial case of the 21st century? AN - 1081890835; 2011-283112 AB - On March 26, 2012, the Supreme Court will begin hearing five and a half hours of argument on the constitutionality of President Obamas health-care law. The court will be deciding on no fewer than four separate constitutional and policy issues relating to the law. At the end of this marathon session, the nine Justices will spend several months pondering whether the so-called Affordable Care Act will survive and serve as testimony to President Obama's ideological boldness -- or become a cautionary lesson in the foolhardiness of pursuing large-scale change without an ideological consensus across party lines. Adapted from the source document. JF - Commentary AU - Troy, Tevi AD - Hudson Institute, Department of Health and Human Services Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 20 EP - 24 PB - American Jewish Committee, New York, NY VL - 133 IS - 2 SN - 0010-2601, 0010-2601 KW - Government - Public officials KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Medicine and health care KW - Business and service sector - Insurance KW - Administration of justice - Courts and judicial power KW - Obama, Barack KW - United States Supreme court KW - Presidents KW - Courts KW - Health insurance KW - Law KW - Health policy KW - Medical service KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081890835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Commentary&rft.atitle=Obama+Care+at+the+Supreme+Court%3A+What+will+be+at+stake+when+the+Justices+hear+the+most+controversial+case+of+the+21st+century%3F&rft.au=Troy%2C+Tevi&rft.aulast=Troy&rft.aufirst=Tevi&rft.date=2012-02-01&rft.volume=133&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Commentary&rft.issn=00102601&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Obama, Barack; Presidents; Health policy; Law; United States Supreme court; Medical service; Health insurance; Legislation; Courts ER - TY - JOUR T1 - Environmental Engineering in IHS AN - 1038290931; 16313109 AB - The Indian Health Service (IHS), an agency of the Department of Health and Human Services, delivers a comprehensive environmental health program to American Indians and Alaska Natives through the Office of Environmental Health and Engineering (OEHE). One of the programs in OEHE is the Sanitation Facilities Construction (SFC) Program. The SFC designs and constructs water, sewer and solid waste infrastructure throughout Indian country. JF - Military Engineer AU - Baer, D AD - SFC dana.baer@ihs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 55 EP - 56 PB - Society of American Military Engineers VL - 104 IS - 675 SN - 0026-3982, 0026-3982 KW - Mechanical & Transportation Engineering Abstracts (MT); Materials Business File (MB); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - American Indians KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038290931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Engineer&rft.atitle=Environmental+Engineering+in+IHS&rft.au=Baer%2C+D&rft.aulast=Baer&rft.aufirst=D&rft.date=2012-02-01&rft.volume=104&rft.issue=675&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Military+Engineer&rft.issn=00263982&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2014-02-14 ER - TY - JOUR T1 - Registration of work-related diseases, injuries, and complaints in Aruba, Bonaire, and Curaçao AN - 1037879198; 4330031 AB - ABSTRACT IN ENGLISH: Objective: To estimate the incidence of work-related diseases, injuries, and complaints in Aruba, Bonaire, and Curaçao and to identify some next steps in the prevention process. Methods: All of the three countries 18 occupational health specialists were asked to participate; 100% agreed to report all work-related diseases, injuries, and complaints in 2004-2008. A standard online notification form was used to register cases in a database maintained by the Netherlands Center for Occupational Diseases (NCOD). The public health service of Curaçao analyzed the data and presented the results to the participating physicians during educational and feedback meetings. Results: During the study period, 1 519 cases were reported: 720 (47.0%) work-related diseases; 515 (34.0%) injuries; and 284 (19.0%) complaints. The mean patient age was 42.4 years (range 16-70 years); 924 (60.8%) were males and 571 (37.6%), females. Most frequently reported were musculoskeletal diseases, injuries, and complaints; mental health disorders; and skin injuries. Analysis showed incidence rates of work-related diseases, injuries, and complaints in Aruba to be 157 new cases per 100 000 employee years; in Bonaire, 53/100 000; and in Curaçao, 437/100 000. Conclusions: These results suggest that labor protection laws need improvement and that preventive action should be fostered. Further study is needed on working conditions, preventive policy, and the quality of occupational health and safety practices in Aruba, Bonaire, and Curaçao. Funding is imperative for collecting and publishing accurate data, which will keep this problem on the social-political agenda. // ABSTRACT IN SPANISH: Objetivo: Calcular la incidencia de enfermedades, lesiones y sintomas relacionados con el trabajo en Aruba, Bonaire y Curazao e identificar los pasos siguientes en el proceso de prevención. Métodos: Se invitó a participar a los 18 especialistas en salud ocupacional de los usó un formulario estándar de notificación en linea para registrar los casos en una base de datos mantenida por el Centro para las Enfermedades Ocupacionales de los Países Bajos. El servicio de salud pública de Curazao analizó los datos y presentó los resultados a los médicos participantes durante las reuniones educativas y de retroalimentación. Resultados: Durante el periodo del estudio se notificaron 1 519 casos relacionados con el trabajo: 720 (47,0%) enfermedades, 515 (34,0%) lesiones y 284 (19,0%) síntomas. La edad promedio de los pacientes fue 42,4 años (recorrido, 16-70 años); 924 (60,8%) eran varones y 571 (37,6%), mujeres. Se notificaron con mayor frecuencia las enfermedades, lesiones y sintomas musculoesqueléticos; los trastornos mentales; y las lesiones cutáneas. El análisis mostró tasas de incidencia de enfermedades, lesiones y sintomas relacionados cor el trabajo de 157 nuevos casos por 100 000 empleados por año en Aruba, 53/100 000 en Bonaire y 437/100 000 en Curazao. Conclusiones: Estos resultados indican que las leyes de protección laboral deben mejorarse y que deben promoverse las medidas preventivas. Es necesario llevar a cabo otros estudios sobre las condiciones de trabajo, los planes de prevención y la calidad de la salud ocupacional y las prácticas de seguridad en Aruba, Bonaire y Curazao. Se requiere financiamiento para recopllar y publicar datos exactos, a fin de mantener este problema en la agenda politica y social. JF - Pan American journal of public health AU - Spreeuwers, Dick AU - Strikwerda, Dagmar C AU - Weel, Andre N.H. AD - University of Amsterdam ; Public Health Service, Willemstad ; Netherlands Society of Occupational Medicine Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 104 EP - 114 VL - 31 IS - 2 SN - 1020-4989, 1020-4989 KW - Sociology KW - Bonaire KW - Curaçao KW - Statistics KW - Doctors KW - Injuries KW - Aruba KW - Safety KW - Diseases KW - Working conditions KW - Public health KW - Occupational health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037879198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pan+American+journal+of+public+health&rft.atitle=Registration+of+work-related+diseases%2C+injuries%2C+and+complaints+in+Aruba%2C+Bonaire%2C+and+Cura%C3%A7ao&rft.au=Spreeuwers%2C+Dick%3BStrikwerda%2C+Dagmar+C%3BWeel%2C+Andre+N.H.&rft.aulast=Spreeuwers&rft.aufirst=Dick&rft.date=2012-02-01&rft.volume=31&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Pan+American+journal+of+public+health&rft.issn=10204989&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8847 5772; 11229; 6555 6220; 10449 5772; 3675 10299 13682 7883 8864; 12233; 3617 6220; 13713 4214; 28 77 14 ER - TY - JOUR T1 - Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings AN - 1034813520; 17013345 AB - Healthcare settings present a challenging environment for assessing low-level concentrations of specific volatile organic compounds (VOCs) in the presence of high background concentrations of alcohol from the use of hand sanitizers and surface disinfectants. The purposes of this laboratory-based project were to develop and validate a sampling and analysis methodology for quantifying low-level VOC concentrations as well as high-level alcohol concentrations found together in healthcare settings. Sampling was conducted using evacuated canisters lined with fused silica. Gas chromatography/mass spectrometry analysis was performed using preconcentration (for ppb levels) and loop injection (for ppm levels). For a select list of 14 VOCs, bias, precision, and accuracy of both the preconcentration and loop injection methods were evaluated, as was analyte stability in evacuated canisters over 30 days. Using the preconcentration (ppb-level) method, all validation criteria were met for 13 of the 14 target analytes-ethanol, acetone, methylene chloride, hexane, chloroform, benzene, methyl methacrylate, toluene, ethylbenzene, m,p-xylene, o-xylene, alpha-pinene, and limonene. Using the loop injection (ppm-level) method, all validation criteria were met for each analyte. At ppm levels, alpha-pinene and limonene remained stable over 21 days, while the rest of the analytes were stable for 30 days. All analytes remained stable over 30 days at ppb levels. This sampling and analysis approach is a viable (i.e., accurate and stable) methodology that will enable development of VOC profiles for mixed exposures experienced by healthcare workers. JF - Journal of Environmental Monitoring AU - LeBouf, Ryan F AU - Stefaniak, Aleksandr B AU - Virji, MAbbas AD - National Institute for Occupational Safety and Health; 1095 Willowdale Road; Morgantown; WV; USA; 26505; +304.285.5820; +304.285.6287; , rlebouf@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 977 EP - 983 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Environment Abstracts KW - Environmental monitoring KW - Alcohol KW - Toluene KW - Chlorides KW - Mass spectrometry KW - Medical personnel KW - Silica KW - Health care KW - Gas chromatography KW - Acetone KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 9999:GENERAL POLLUTION KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034813520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Validation+of+evacuated+canisters+for+sampling+volatile+organic+compounds+in+healthcare+settings&rft.au=LeBouf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B%3BVirji%2C+MAbbas&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10896h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 18 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Gas chromatography; Mass spectrometry; Alcohol; Silica; Health care; Toluene; Chlorides; Acetone; Medical personnel; Volatile organic compounds DO - http://dx.doi.org/10.1039/c2em10896h ER - TY - JOUR T1 - Use of denuder/filter apparatus to investigate terpene ozonolysis AN - 1034811750; 17013335 AB - A denuder/filter apparatus was used to collect the gaseous and particulate reaction products from ozonlysis of alpha -pinene, limonene and alpha -terpineol in an effort to develop sampling techniques for characterizing indoor environment chemistry. Carboxylic acids found in the particulate phase were derivatized to 2,2,2-trifuoroethylamides by reaction with 3-ethyl-1-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDC) and 2,2,2-trifluoroethylamine hydrochloride (TFEA). Carbonyl compounds collected in both gas phase and particulate phase were derivatized to their respective oximes by reaction with O-(2,3,4,5,6-pentafluoro-benzyl)hydroxylamine hydrochloride (PFBHA). The ozonolysis of alpha -pinene yielded the carboxylic acids: cis-pinonic acid and pinic acid and the proposed carboxylic acids methanetricarboxylic acid and terpenylic acid; the carbonyls: 4-oxopentanal, norpinonaldehyde, pinon aldehyde and the proposed carbonyl methylidenepropanedial. The ozonolysis of limonene yielded the carboxylic acids: limonic acid and pinic acid and the carbonyls: 1-(4-methylcyclohex-3-en-1-yl)ethanone (4AMCH), glyoxal, methyl glyoxal, 4-oxopentanal and 6-oxo-3-(prop-1-en-2-yl)heptanal (IPOH). The ozonolysis of alpha -terpineol yielded the proposed carboxylic acids: terpenylic acid and homoterpenylic acid and the carbonyls: (5E)-6-hydroxyhept-5-en-2-one, methyl glyoxal and 4-oxopentanal. JF - Journal of Environmental Monitoring AU - Wells, J R AD - Exposure Assessment Branch; Health Effects Laboratory Division; National Institute for Occupational Safety and Health; 1095 Willowdale Road; Morgantown; WV; 26505; USA; +1-304-285-6041; +1-304-285-6341; , ozw0@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 1044 EP - 1054 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Environment Abstracts KW - Filters KW - Carboxylic acids KW - Particulates KW - Aldehydes KW - Indoor environments KW - Carbonyl compounds KW - Ozonation KW - P 9999:GENERAL POLLUTION KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Use+of+denuder%2Ffilter+apparatus+to+investigate+terpene+ozonolysis&rft.au=Wells%2C+J+R&rft.aulast=Wells&rft.aufirst=J&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10799f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 69 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Filters; Carboxylic acids; Particulates; Indoor environments; Aldehydes; Carbonyl compounds; Ozonation DO - http://dx.doi.org/10.1039/c2em10799f ER - TY - JOUR T1 - Comparison of DNA extraction methodologies used for assessing fungal diversity viaITS sequencing AN - 1034811733; 17013334 AB - Traditional methods of assessing fungal exposure have been confounded by a number of limiting variables. The recent utilization of molecular methods such as internal transcribed spacer (ITS) sequencing of ribosomal RNA genes has provided improved insight into the diversity of fungal bioaerosols in indoor, outdoor and occupational environments. However, ITS analyses may also be confounded by a number of methodological limitations. In this study, we have optimized this technology for use in occupational or environmental studies. Three commonly used DNA extraction methodologies (UltraClean Soil kit, High Pure PCR Template kit, and EluQuik/DNeasy kit) were compared in terms of sensitivity and susceptibility to PCR inhibitors in dust for three common fungal bioaerosols, Aspergillus versicolor, Rhizopus microsporusand Wallemia sebi. Environmental dust samples were then studied using each extraction methodology and results were compared to viable culture data. The extraction methods differed in terms of their ability to efficiently extract DNA from particular species of fungi (e.g. Aspergillus versicolor). In addition, the ability to remove PCR inhibitors from dust samples was most effective using the soil DNA extraction kit. The species composition varied greatly between ITS clone libraries generated with the different DNA extraction kits. However, compared to viable culture data, ITS clone libraries included additional fungal species that are incapable of growth on solid culture medium. Collectively, our data indicated that DNA extraction methodologies used in ITS sequencing studies of occupational or environmental dust samples can greatly influence the fungal species that are detected. JF - Journal of Environmental Monitoring AU - Rittenour, William R AU - Park, Ju-Hyeong AU - Cox-Ganser, Jean M AU - Beezhold, Donald H AU - Green, Brett J AD - Allergy and Clinical Immunology Branch; Health Effects Laboratory Division; National Institute for Occupational Safety and Health; 1095 Willowdale Rd.; Morgantown; West Virginia; USA; +1 304-285-5721 ext 7; , ikx8@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 766 EP - 774 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Environment Abstracts; Pollution Abstracts KW - Aerosols KW - Aspergillus versicolor KW - DNA KW - Dust KW - P 0000:AIR POLLUTION KW - K 03450:Ecology KW - N 14810:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Comparison+of+DNA+extraction+methodologies+used+for+assessing+fungal+diversity+viaITS+sequencing&rft.au=Rittenour%2C+William+R%3BPark%2C+Ju-Hyeong%3BCox-Ganser%2C+Jean+M%3BBeezhold%2C+Donald+H%3BGreen%2C+Brett+J&rft.aulast=Rittenour&rft.aufirst=William&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10779a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Dust; DNA; Aspergillus versicolor DO - http://dx.doi.org/10.1039/c2em10779a ER - TY - JOUR T1 - Predicting perceived image quality: a critique of Lin and Kuo (2011). AN - 1024646515; pmid-22582691 AB - A recent study by Lin and Kuo reported on the image quality of a small mobile display under different ambient illumination levels. In this commentary, the present author discusses the limitations of their approach with respect to the rigorous quantification of image quality and the caveats associated with preference studies of new display technologies. Quantitatively predicting image quality using preference-based methods can be useful for initial decisions in early phases of product development, but provides limited value for the rigorous quantification of image quality of display devices. JF - Perceptual and motor skills AU - Badano, Aldo AD - Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA, Silver Spring, Maryland 20993, USA. aldo.badano@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 236 EP - 238 VL - 114 IS - 1 SN - 0031-5125, 0031-5125 KW - National Library of Medicine KW - *Cellular Phone KW - *Color Perception KW - Female KW - Humans KW - *Lighting KW - Male KW - *Pattern Recognition, Visual KW - *User-Computer Interface UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024646515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Predicting+perceived+image+quality%3A+a+critique+of+Lin+and+Kuo+%282011%29.&rft.au=Badano%2C+Aldo&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2012-02-01&rft.volume=114&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-11 N1 - SuppNotes - Comment On: Percept Mot Skills. 2011 Aug;113(1):215-28[21987921] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Measurement of impulse peak insertion loss for four hearing protection devices in field conditions AN - 1018377803; 201211413 AB - Objective: In 2009, the U.S. Environmental Protection Agency (EPA) proposed an impulse noise reduction rating (NRR) for hearing protection devices based upon the impulse peak insertion loss (IPIL) methods in the ANSI S12.42-2010 standard. This study tests the ANSI S12.42 methods with a range of hearing protection devices measured in field conditions. Design: The method utilizes an acoustic test fixture and three ranges for impulse levels: 130-134, 148-152, and 166-170 dB peak SPL. For this study, four different models of hearing protectors were tested: Bilsom 707 Impact II electronic earmuff, E.A.R Pod Express, E.A.R Combat Arms version 4, and the Etymotic Research, Inc. Electronic BlastPLG EB1. Study sample: Five samples of each protector were fitted on the fixture or inserted in the fixture's ear canal five times for each impulse level. Impulses were generated by a 0.223 caliber rifle. Results: The average IPILs increased with peak pressure and ranged between 20 and 38 dB. For some protectors, significant differences were observed across protector examples of the same model, and across insertions. Conclusions: The EPA's proposed methods provide consistent and reproducible results. The proposed impulse NRR rating should utilize the minimum and maximum protection percentiles as determined by the ANSI S12.42-2010 methods. Adapted from the source document. JF - International Journal of Audiology AU - Murphy, William J AU - Flamme, Gregory A AU - Meinke, Deanna K AU - Sondergaard, Jacob AU - Finan, Donald S AU - Lankford, James E AU - Khan, Amir AU - Vernon, Julia AU - Stewart, Michael AD - Hearing Loss Prevention Team, National Institute for Occupational Safety and Health Y1 - 2012/02// PY - 2012 DA - February 2012 SP - s31 EP - s42 PB - Informa Healthcare, Taylor and Francis, London UK VL - 51 IS - supplement 1 SN - 1499-2027, 1499-2027 KW - Hearing protection devices, impulse noise, noise reduction rating, noise-induced hearing loss KW - Measurement KW - Noise KW - Hearing protectors KW - Hearing KW - Hearing impairment KW - Arms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018377803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Measurement+of+impulse+peak+insertion+loss+for+four+hearing+protection+devices+in+field+conditions&rft.au=Murphy%2C+William+J%3BFlamme%2C+Gregory+A%3BMeinke%2C+Deanna+K%3BSondergaard%2C+Jacob%3BFinan%2C+Donald+S%3BLankford%2C+James+E%3BKhan%2C+Amir%3BVernon%2C+Julia%3BStewart%2C+Michael&rft.aulast=Murphy&rft.aufirst=William&rft.date=2012-02-01&rft.volume=51&rft.issue=supplement+1&rft.spage=s31&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.630330 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing; Arms; Hearing protectors; Hearing impairment; Measurement; Noise DO - http://dx.doi.org/10.3109/14992027.2011.630330 ER - TY - JOUR T1 - Tissue and cellular distribution of gold nanoparticles varies based on aggregation/agglomeration status AN - 1017980554; 16751406 AB - Aim: The ability of nanoparticles to form larger superstructures of aggregates and agglomerates has been extensively noted in the literature. The in vivo biological impact of these structures, however, has not been assessed. This knowledge gap is especially critical in the safety assessment of nanoparticles to be used for therapeutic purposes. Method/results: Here we show that when administered intravenously into a mouse model, gold nanoparticle superstructures of reversible agglomerates and irreversible aggregates demonstrate significant differences in organ and cellular distribution compared with the primary particle building blocks. In addition, different structures produced different blood serum chemistry data. Conclusion: These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration. JF - Nanomedicine AU - Keene, Athena M AU - Peters, David AU - Rouse, Rodney AU - Stewart, Sharron AU - Rosen, Elliot T AU - Tyner, Katherine M AD - US FDA, Center for Drug Evaluation & Research, Office of Testing & Research, Division of Drug Safety Research, Building 64 Room 2086 HFD 910, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA., katherine.tyner@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 199 EP - 209 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 7 IS - 2 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Agglomeration KW - Animal models KW - Blood KW - Data processing KW - Gold KW - Therapeutic applications KW - Toxicity KW - nanoparticles KW - nanotechnology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017980554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Tissue+and+cellular+distribution+of+gold+nanoparticles+varies+based+on+aggregation%2Fagglomeration+status&rft.au=Keene%2C+Athena+M%3BPeters%2C+David%3BRouse%2C+Rodney%3BStewart%2C+Sharron%3BRosen%2C+Elliot+T%3BTyner%2C+Katherine+M&rft.aulast=Keene&rft.aufirst=Athena&rft.date=2012-02-01&rft.volume=7&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.11.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 32 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Blood; Data processing; Animal models; Therapeutic applications; Gold; Toxicity; nanoparticles; Agglomeration; nanotechnology DO - http://dx.doi.org/10.2217/nnm.11.125 ER - TY - JOUR T1 - Geostatistical modeling of the gas emission zone and its in-place gas content for Pittsburgh-seam mines using sequential Gaussian simulation AN - 1015462567; 2012-049606 AB - Determination of the size of the gas emission zone, the locations of gas sources within, and especially the amount of gas retained in those zones is one of the most important steps for designing a successful methane control strategy and an efficient ventilation system in longwall coal mining. The formation of the gas emission zone and the potential amount of gas-in-place (GIP) that might be available for migration into a mine are factors of local geology and rock properties that usually show spatial variability in continuity and may also show geometric anisotropy. Geostatistical methods are used here for modeling and prediction of gas amounts and for assessing their associated uncertainty in gas emission zones of longwall mines for methane control. This study used core data obtained from 276 vertical exploration boreholes drilled from the surface to the bottom of the Pittsburgh coal seam in a mining district in the Northern Appalachian basin. After identifying important coal and non-coal layers for the gas emission zone, univariate statistical and semivariogram analyses were conducted for data from different formations to define the distribution and continuity of various attributes. Sequential simulations performed stochastic assessment of these attributes, such as gas content, strata thickness, and strata displacement. These analyses were followed by calculations of gas-in-place and their uncertainties in the Pittsburgh seam caved zone and fractured zone of longwall mines in this mining district. Grid blanking was used to isolate the volume over the actual panels from the entire modeled district and to calculate gas amounts that were directly related to the emissions in longwall mines. Results indicated that gas-in-place in the Pittsburgh seam, in the caved zone and in the fractured zone, as well as displacements in major rock units, showed spatial correlations that could be modeled and estimated using geostatistical methods. This study showed that GIP volumes may change up to 3 MMscf per acre and, in a multi-panel district, may total 9 Bcf of methane within the gas emission zone. Therefore, ventilation and gas capture systems should be designed accordingly. In addition, rock displacements within the gas emission zone are spatially distributed. From an engineering and practical point of view, spatial distributions of GIP and distributions of rock displacements should be correlated with in-mine emissions and gob gas venthole productions. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Olea, Ricardo A AU - Goodman, Gerrit Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 50 EP - 71 PB - Elsevier, Amsterdam VL - 90-91 SN - 0166-5162, 0166-5162 KW - United States KW - North America KW - mining KW - Pittsburgh Coal KW - underground mining KW - Pennsylvanian KW - Paleozoic KW - natural gas KW - statistical analysis KW - data processing KW - Carboniferous KW - petroleum KW - coal seams KW - sedimentary rocks KW - longwall mining KW - Appalachian Basin KW - coal KW - digital simulation KW - coalbed methane KW - Pennsylvania KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1015462567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Geostatistical+modeling+of+the+gas+emission+zone+and+its+in-place+gas+content+for+Pittsburgh-seam+mines+using+sequential+Gaussian+simulation&rft.au=Karacan%2C+C+Ozgen%3BOlea%2C+Ricardo+A%3BGoodman%2C+Gerrit&rft.aulast=Karacan&rft.aufirst=C&rft.date=2012-02-01&rft.volume=90-91&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.10.010 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 40 N1 - Document feature - illus. incl. 16 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Appalachian Basin; Carboniferous; coal; coal seams; coalbed methane; data processing; digital simulation; longwall mining; mining; natural gas; North America; Paleozoic; Pennsylvania; Pennsylvanian; petroleum; Pittsburgh Coal; sedimentary rocks; statistical analysis; underground mining; United States DO - http://dx.doi.org/10.1016/j.coal.2011.10.010 ER - TY - RPRT T1 - Coaching as a Key Component in Teachers' Professional Development: Improving Classroom Practices in Head Start Settings. OPRE Report 2012-4 AN - 1011397262; ED530434 AB - Head Start CARES (Classroom-based Approaches and Resources for Emotion and Social Skill Promotion) is a large-scale, national research demonstration that was designed to test the effects of a one-year program aimed at improving pre-kindergarteners' social and emotional readiness for school. To facilitate the delivery of the program, teachers attended training workshops and worked with coaches throughout the school year. This report focuses on the planning and implementation of the coaching component in the Head Start CARES demonstration. Beginning with an overview of coaching as a model of professional development generally and the demonstration's coaching model in particular, the report then offers practical lessons learned about coaching social-emotional curricula in a large and complex early childhood education system. Geared toward early childhood education administrators and practitioners who are interested in adopting or modifying a coaching model, the lessons learned address the selection of the coaching model; coach hiring and training; coaching processes; coach support and supervision; and program management, data, and quality assurance. (Contains 4 tables, 1 box and 22 footnotes.) AU - Lloyd, Chrrishana M. AU - Modlin, Emmily L. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 32 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Workshops KW - Low Income Groups KW - Coaching (Performance) KW - Quality Assurance KW - Early Childhood Education KW - Professional Development KW - Teacher Effectiveness KW - Emotional Development KW - Interpersonal Competence KW - Early Intervention KW - Disadvantaged Youth KW - Teacher Recruitment KW - Social Development KW - Preschool Children KW - School Readiness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011397262?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Detonability of natural gas-air mixtures AN - 1010894037; 16188609 AB - Direct initiation experiments were carried out in a 105 cm diameter tube to study detonation properties and evaluate the detonability limits for mixtures of natural gas (NG) with air. The natural gas was primarily methane with 1.5-1.7% of ethane. A stoichiometric methane-oxygen mixture contained in a large plastic bag was used as a detonation initiator. Self-supporting detonations with velocities and pressures close to theoretical CJ values were observed in NG-air mixtures containing from 5.3% to 15.6% of NG at atmospheric pressure. These detonability limits are wider than previously measured in smaller channels, and close to the flammability limits. Detonation cell patterns recorded near the limits vary from large cells of the size of the tube to spiral traces of spin detonations. Away from the limits, detonation cell sizes decrease to about 20 cm for 10% NG, and are consistent with existing data for methane-air mixtures obtained in smaller channels. Observed cell patterns are very irregular, and contain secondary cell structures inside primary cells and fine structures inside spin traces. JF - Combustion and Flame AU - Gamezo, Vadim N AU - Zipf, RKarl AU - Sapko, Michael J AU - Marchewka, Walter P AU - Mohamed, Khaled M AU - Oran, Elaine S AU - Kessler, David A AU - Weiss, Eric S AU - Addis, James D AU - Karnack, Frank A AU - Sellers, Donald D AD - Office of Mine Safety and Health Research (OMSHR), National Institute for Occupational Safety and Health (NIOSH), Pittsburgh, PA 15236, USA gamezo@lcp.nrl.navy.mil Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 870 EP - 881 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 159 IS - 2 SN - 0010-2180, 0010-2180 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); Aerospace & High Technology Database (AH) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010894037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combustion+and+Flame&rft.atitle=Detonability+of+natural+gas-air+mixtures&rft.au=Gamezo%2C+Vadim+N%3BZipf%2C+RKarl%3BSapko%2C+Michael+J%3BMarchewka%2C+Walter+P%3BMohamed%2C+Khaled+M%3BOran%2C+Elaine+S%3BKessler%2C+David+A%3BWeiss%2C+Eric+S%3BAddis%2C+James+D%3BKarnack%2C+Frank+A%3BSellers%2C+Donald+D&rft.aulast=Gamezo&rft.aufirst=Vadim&rft.date=2012-02-01&rft.volume=159&rft.issue=2&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Combustion+and+Flame&rft.issn=00102180&rft_id=info:doi/10.1016%2Fj.combustflame.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-05-04 DO - http://dx.doi.org/10.1016/j.combustflame.2011.08.009 ER - TY - JOUR T1 - Meat consumption and the risk of incident distal colon and rectal adenoma. AN - 919649675; 22166801 AB - Most studies of meat and colorectal adenoma have investigated prevalent events from a single screening, thus limiting our understanding of the role of meat and meat-related exposures in early colorectal carcinogenesis. Among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who underwent baseline and follow-up sigmoidoscopy (n=17,072), we identified 1008 individuals with incident distal colorectal adenoma. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between meat and meat-related components and incident distal colorectal adenoma using multivariate logistic regression. We observed suggestive positive associations for red meat, processed meat, haeme iron, and nitrate/nitrite with distal colorectal adenoma. Grilled meat (OR=1.56, 95% CI=1.04-2.36), well or very well-done meat (OR=1.59, 95% CI=1.05-2.43), 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) (OR=1.75, 95% CI=1.17-2.64), benzo[a]pyrene (OR=1.53, 95% CI=1.06-2.20), and total mutagenic activity (OR=1.57, 95% CI=1.03-2.40) were positively associated with rectal adenoma. Total iron (diet and supplements) (OR=0.69, 95% CI=0.56-0.86) and iron from supplements (OR=0.65, 95% CI=0.44-0.97) were inversely associated with any distal colorectal adenoma. Our findings indicate that several meat-related components may be most relevant to early neoplasia in the rectum. In contrast, total iron and iron from supplements were inversely associated with any distal colorectal adenoma. JF - British journal of cancer AU - Ferrucci, L M AU - Sinha, R AU - Huang, W-Y AU - Berndt, S I AU - Katki, H A AU - Schoen, R E AU - Hayes, R B AU - Cross, A J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2012/01/31/ PY - 2012 DA - 2012 Jan 31 SP - 608 EP - 616 VL - 106 IS - 3 KW - Index Medicus KW - Sigmoidoscopy KW - Colon -- pathology KW - Risk Factors KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Meat KW - Adenoma -- epidemiology KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919649675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Meat+consumption+and+the+risk+of+incident+distal+colon+and+rectal+adenoma.&rft.au=Ferrucci%2C+L+M%3BSinha%2C+R%3BHuang%2C+W-Y%3BBerndt%2C+S+I%3BKatki%2C+H+A%3BSchoen%2C+R+E%3BHayes%2C+R+B%3BCross%2C+A+J&rft.aulast=Ferrucci&rft.aufirst=L&rft.date=2012-01-31&rft.volume=106&rft.issue=3&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fbjc.2011.549 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2012-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 2011;63(4):583-92 [21598178] Carcinogenesis. 2011 Feb;32(2):203-9 [21081473] Cancer Prev Res (Phila). 2011 Oct;4(10):1686-97 [21803984] Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Cancer Epidemiol Biomarkers Prev. 2000 Jun;9(6):625-30 [10868699] Carcinogenesis. 2000 Oct;21(10):1909-15 [11023550] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] Nutr Rev. 2001 May;59(5):140-8 [11396694] Jpn J Cancer Res. 2002 May;93(5):478-83 [12036442] Mutat Res. 2002 Aug 26;519(1-2):151-61 [12160900] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Mutat Res. 2002 Sep 30;506-507:205-14 [12351160] Am J Epidemiol. 2003 Mar 1;157(5):434-45 [12615608] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] J Natl Cancer Inst. 2004 Mar 3;96(5):403-7 [14996862] J Nutr. 2004 Apr;134(4):776-84 [15051825] Eur J Cancer Prev. 2004 Jun;13(3):159-64 [15167213] Carcinogenesis. 2004 Jul;25(7):1211-8 [14988221] J Nutr. 2004 Oct;134(10):2711-6 [15465771] Mutat Res. 1975 Dec;31(6):347-64 [768755] Int J Cancer. 1981;27(4):471-4 [7275353] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Carcinogenesis. 1991 Aug;12(8):1503-6 [1860171] Int J Cancer. 1991 Oct 21;49(4):520-5 [1917152] J Natl Cancer Inst. 1992 Jan 15;84(2):91-8 [1310511] Int J Cancer. 1994 Feb 1;56(3):379-82 [8314326] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Am J Epidemiol. 1995 Oct 1;142(7):692-8 [7572938] Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):503-7 [8827353] Am J Epidemiol. 1996 Dec 1;144(11):1005-14 [8942430] Cancer Epidemiol Biomarkers Prev. 1997 Dec;6(12):1029-32 [9419398] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):15-24 [9950235] Lancet. 1999 Feb 27;353(9154):703-7 [10073512] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Cancer Res. 1999 Sep 1;59(17):4320-4 [10485479] Cancer Lett. 1999 Sep 1;143(2):189-94 [10503902] J Natl Cancer Inst. 2005 Feb 2;97(3):232-3; author reply 233-4 [15687367] Carcinogenesis. 2005 Mar;26(3):637-42 [15579480] J Natl Cancer Inst. 2005 Jun 15;97(12):917-26 [15956653] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Am J Gastroenterol. 2005 Dec;100(12):2789-95 [16393237] Int J Cancer. 2006 Jun 15;118(12):3147-52 [16425287] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):717-25 [16614114] Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1120-5 [16775169] Am J Epidemiol. 2006 Dec 1;164(11):1085-93 [16990408] Med Hypotheses. 2007;68(3):562-4 [17045417] Int J Cancer. 2007 Jul 1;121(1):136-42 [17354224] Carcinogenesis. 2007 Jun;28(6):1210-6 [17277235] Br J Cancer. 2007 Jul 2;97(1):118-22 [17551493] Carcinogenesis. 2007 Sep;28(9):2019-27 [17690112] Am J Clin Nutr. 2009 May;89(5):1418-24 [19261727] Am J Gastroenterol. 2009 May;104(5):1231-40 [19367270] Cancer Res. 2010 Mar 15;70(6):2406-14 [20215514] Cancer Prev Res (Phila). 2011 Sep;4(9):1465-75 [21685236] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/bjc.2011.549 ER - TY - BOOK T1 - A Bibliography of Studies Using Temporary Assistance for Needy Families (TANF)-Linked Administrative Data AN - 1266175296; 2011-360444 AB - Since its inception in 1996, the Temporary Assistance for Needy Families (TANF) program has been subject to much study. Some of this work has involved linking TANF administrative data to other administrative data sources, either to improve program administration or to answer program and research questions. Researchers, program administrators, and policy makers considering similar linkages to address research, programmatic, and operational questions can learn from past efforts. This report describes the use of administrative data for program administration and provides a bibliography of TANF research involving linked administrative data. Tables, References. JF - Urban Institute, Jan 31 2012, 46 pp. AU - Johnson, Paul AU - Kaminski, James AU - Scott, Molly M AU - Whitesell, Anne Y1 - 2012/01/31/ PY - 2012 DA - 2012 Jan 31 PB - Urban Institute KW - Social conditions and policy - Urban conditions KW - Social conditions and policy - Marriage and family life KW - Social conditions and policy - Social policy and social development KW - Education and education policy - Information services and sources KW - Social conditions and policy - Social conditions and problems KW - Economic conditions and policy - Economic conditions KW - Poverty relief KW - Bibliography KW - Poverty KW - Urban policy KW - Family KW - Social policy KW - Social insurance KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266175296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+Paul%3BKaminski%2C+James%3BScott%2C+Molly+M%3BWhitesell%2C+Anne&rft.aulast=Johnson&rft.aufirst=Paul&rft.date=2012-01-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.title=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.issn=&rft_id=info:doi/ L2 - http://www.urban.org/UploadedPDF/412540-A-Bibliography-of-Studies-Using-Temporary-Assistance-for-Needy-Families-Linked-Administrative-Data.pdf LA - English DB - PAIS Index N1 - Date revised - 2013-01-01 N1 - Publication note - Urban Institute, 2012 N1 - Last updated - 2016-09-28 ER - TY - CPAPER T1 - Expression Profiles of Human Interferon-alpha and Interferon-lambda Subtypes Are Ligand- and Cell- Dependent T2 - 10th Cytokines and Inflammation Conference AN - 1313110112; 6154687 JF - 10th Cytokines and Inflammation Conference AU - Rabin, Ronald Y1 - 2012/01/30/ PY - 2012 DA - 2012 Jan 30 KW - a-Interferon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313110112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Cytokines+and+Inflammation+Conference&rft.atitle=Expression+Profiles+of+Human+Interferon-alpha+and+Interferon-lambda+Subtypes+Are+Ligand-+and+Cell-+Dependent&rft.au=Rabin%2C+Ronald&rft.aulast=Rabin&rft.aufirst=Ronald&rft.date=2012-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/index.php?option=com_conference&file=program&cn=10th%20Cytokines%20and%20Inflammation%20Conference&cid=51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. AN - 912643977; 22085607 AB - Occupational exposure to welding fumes (WF) is thought to cause Parkinson's disease (PD)-like neurological dysfunction. An apprehension that WF may accelerate the onset of PD also exists. Identifying reliable biomarkers of exposure and neurotoxicity are therefore critical for biomonitoring and neurological risk characterization of WF exposure. Manganese (Mn) in welding consumables is considered the causative factor for the neurological deficits seen in welders. Hence, we sought to determine if Mn accumulation in blood or nail clippings can be a marker for adverse exposure and neurotoxicity. To model this, rats were exposed by intratracheal instillation to dissolved or suspended fume components collected from gas metal arc-mild steel (GMA-MS) or manual metal arc-hard surfacing (MMA-HS) welding. Trace element analysis revealed selective Mn accumulation in dopaminergic brain areas, striatum (STR) and midbrain (MB), following exposure to the two fumes. This caused dopaminergic abnormality as evidenced by loss of striatal tyrosine hydroxylase (Th; 25-32% decrease) and Parkinson disease (autosomal recessive, early onset) 7 (Park7; 25-46% decrease) proteins. While blood Mn was not detectable, Mn levels in nails strongly correlated with the pattern of Mn accumulation in the striatum (R(2)=0.9386) and midbrain (R(2)=0.9332). Exposure to manganese chloride (MnCl(2)) caused similar Mn accumulation in STR, MB and nail. Our findings suggest that nail Mn has the potential to be a sensitive and reliable biomarker for long-term Mn exposure and associated neurotoxicity. The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Andrews, Ronnee N AU - Kashon, Michael L AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2012/01/27/ PY - 2012 DA - 2012 Jan 27 SP - 73 EP - 82 VL - 291 IS - 1-3 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Metals KW - Manganese KW - 42Z2K6ZL8P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Dopamine -- physiology KW - Brain -- metabolism KW - Tissue Distribution KW - Lung -- metabolism KW - Metals -- analysis KW - Metals -- pharmacokinetics KW - Rats KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Atmosphere Exposure Chambers KW - Environmental Monitoring -- methods KW - Male KW - Manganese -- metabolism KW - Air Pollutants, Occupational -- adverse effects KW - Air Pollutants, Occupational -- toxicity KW - Manganese Poisoning -- metabolism KW - Nails -- metabolism KW - Manganese -- adverse effects KW - Inhalation Exposure -- analysis KW - Biomarkers -- analysis KW - Hoof and Claw -- metabolism KW - Welding KW - Occupational Exposure -- adverse effects KW - Manganese -- pharmacokinetics KW - Nails -- chemistry KW - Occupational Exposure -- analysis KW - Hoof and Claw -- chemistry KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912643977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BAndrews%2C+Ronnee+N%3BKashon%2C+Michael+L%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2012-01-27&rft.volume=291&rft.issue=1-3&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.10.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-06 N1 - Date created - 2011-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2011.10.021 ER - TY - JOUR T1 - Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients AN - 926880435; 16297584 AB - Unlike professional caregivers such as physicians and nurses, informal caregivers, typically family members or friends, provide care to individuals with a variety of conditions including advanced age, dementia, and cancer. This experience is commonly perceived as a chronic stressor, and caregivers often experience negative psychological, behavioral, and physiological effects on their daily lives and health. In this report, we describe the experience of a 53-year-old woman who is the sole caregiver for her husband, who has acute myelogenous leukemia and was undergoing allogeneic hematopoietic stem cell transplantation. During his intense and unpredictable course, the caregiver's burden is complex and complicated by multiple competing priorities. Because caregivers are often faced with multiple concurrent stressful events and extended, unrelenting stress, they may experience negative health effects, mediated in part by immune and autonomic dysregulation. Physicians and their interdisciplinary teams are presented daily with individuals providing such care and have opportunity to intervene. This report describes a case that exemplifies caregiving burden and discusses the importance of identifying caregivers at risk of negative health outcomes and intervening to attenuate the stress associated with the caregiving experience. JF - JAMA: Journal of the American Medical Association AU - Bevans, Margaret AU - Sternberg, Esther M AD - Author Affiliations: US Public Health Service, Clinical Nurse Scientist, Nursing Research & Translational Science, Nursing & Patient Care Services, Health Clinical Center (Dr Bevans) Y1 - 2012/01/25/ PY - 2012 DA - 2012 Jan 25 SP - 398 EP - 403 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 307 IS - 4 SN - 0098-7484, 0098-7484 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Dementia disorders KW - Leukemia KW - Medical personnel KW - Nursing KW - Perception KW - Psychology KW - Stem cells KW - Stress KW - dementia disorders KW - nursing KW - stem cells KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926880435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Caregiving+Burden%2C+Stress%2C+and+Health+Effects+Among+Family+Caregivers+of+Adult+Cancer+Patients&rft.au=Bevans%2C+Margaret%3BSternberg%2C+Esther+M&rft.aulast=Bevans&rft.aufirst=Margaret&rft.date=2012-01-25&rft.volume=307&rft.issue=4&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Leukemia; Stem cells; Psychology; Perception; stem cells; Nursing; Dementia disorders; Stress; dementia disorders; nursing; Medical personnel; Cancer ER - TY - CPAPER T1 - Quality by Design and Analytical Methods T2 - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AN - 1313096587; 6118171 JF - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AU - Moore, Christine Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313096587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=Quality+by+Design+and+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://isranalytica.org.il/Isranalytica2012/Scientific%20Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Quality by Design in Process Analytical Technology (PAT) and Real Time Release Testing (RTRT) Analytical Methods T2 - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AN - 1312981238; 6118177 JF - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AU - Moore, Christine Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=The+Role+of+Quality+by+Design+in+Process+Analytical+Technology+%28PAT%29+and+Real+Time+Release+Testing+%28RTRT%29+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://isranalytica.org.il/Isranalytica2012/Scientific%20Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cloning and expression of a Trichoderma longibrachiatum beta -mannanase gene in Pichia pastoris AN - 1020848411; 16778014 AB - Trichoderma species are among the primary producers of beta -mannanase, an enzyme that catalyses the hydrolysis of beta -1, 4-glycosidic linkages in mannans and heteromannans. In this study, a Trichoderma species producing high mannanase activity was identified as Trichoderma longibrachiatum based on sequence analysis of its rDNA internal transcribed spacer region. The open reading frame of the gene encoding for beta -mannanase of T. longibrachiatum, man1 is 1,441 bp and is separated by two introns. The MAN1 amino acid sequence showed 95% identity to Trichoderma reesei beta -mannanase. Domain analysis classified MAN1 as a member of glycosyl hydrolase family 5 and detected the presence of a carbohydrate-binding domain family 1 at its C-terminus. The recombinant mannanase, rMAN1, was successfully expressed as a similar to 60 kDa extracellular recombinant protein in Pichia pastoris and was verified via western blotting analyses. The specific activity of the purified rMAN1 was 1416.18 U/mg. The optimal rMAN1 activity was recorded at 55 degree C and pH 5. The enzyme was stable with 30 min pre-incubation at temperatures ranging from 4 to 50 degree C. The enzyme was stable at pH 4 to 7 but became progressively unstable at pH values below 3 and above 8. rMAN1 had a high affinity towards locust bean gum as a substrate, with a K sub(m) value of 0.95 mg/ml. JF - African Journal of Biotechnology AU - Lim, J L AU - Bakar, FDA AU - Yusof, H M AU - Murad, AMA AD - School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, munir@ukm.my Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 SP - 1705 EP - 1718 VL - 11 IS - 7 SN - 1684-5315, 1684-5315 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Western blotting KW - mannan KW - C-Terminus KW - Enzymes KW - Hydrolysis KW - Beans KW - Spacer region KW - Introns KW - Trichoderma longibrachiatum KW - Hypocrea jecorina KW - Glycosyl hydrolase KW - Pichia pastoris KW - pH effects KW - Open reading frames KW - Catalysis KW - Amino acid sequence KW - W 30925:Genetic Engineering KW - G 07800:Plants and Algae KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020848411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=African+Journal+of+Biotechnology&rft.atitle=Cloning+and+expression+of+a+Trichoderma+longibrachiatum+beta+-mannanase+gene+in+Pichia+pastoris&rft.au=Lim%2C+J+L%3BBakar%2C+FDA%3BYusof%2C+H+M%3BMurad%2C+AMA&rft.aulast=Lim&rft.aufirst=J&rft.date=2012-01-24&rft.volume=11&rft.issue=7&rft.spage=1705&rft.isbn=&rft.btitle=&rft.title=African+Journal+of+Biotechnology&rft.issn=16845315&rft_id=info:doi/10.5897%2FAJB11.2046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Temperature effects; Western blotting; mannan; C-Terminus; Enzymes; Hydrolysis; Beans; Spacer region; Introns; Glycosyl hydrolase; pH effects; Open reading frames; Amino acid sequence; Catalysis; Trichoderma longibrachiatum; Hypocrea jecorina; Pichia pastoris DO - http://dx.doi.org/10.5897/AJB11.2046 ER - TY - CPAPER T1 - Challenges in Development of Melamine Analysis in Food Contamination T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313083044; 6117527 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Krynitsky, Alexander Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Food contamination KW - melamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313083044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Challenges+in+Development+of+Melamine+Analysis+in+Food+Contamination&rft.au=Krynitsky%2C+Alexander&rft.aulast=Krynitsky&rft.aufirst=Alexander&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Refractive Index Effects in Raman Imaging T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313072819; 6117451 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Kauffman, John AU - Mecker, Laura Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Imaging techniques KW - Refractive index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313072819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Refractive+Index+Effects+in+Raman+Imaging&rft.au=Kauffman%2C+John%3BMecker%2C+Laura&rft.aulast=Kauffman&rft.aufirst=John&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspective on Continuous Manufacturing T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313067916; 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6117530 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - McGrath, Timothy Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Food processing KW - Food plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313067728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=FSMA+and+what+is+Might+Mean+for+Domestic+and+International+Food+Processing+Plants+in+Terms+of+Changes+to+Testing+Requirements&rft.au=McGrath%2C+Timothy&rft.aulast=McGrath&rft.aufirst=Timothy&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pesticide Residue Analysis (QuEChERS, LC and GC-MS) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313067690; 6117529 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Wong, Jon Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pesticide residues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313067690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Pesticide+Residue+Analysis+%28QuEChERS%2C+LC+and+GC-MS%29&rft.au=Wong%2C+Jon&rft.aulast=Wong&rft.aufirst=Jon&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Deep Ultraviolet Resonance Raman Spectroscopy in Application of Quality Control of Therapeutic Proteins T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313066716; 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6117367 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Woodcock, Janet Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313065155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=FDA+Brings+Science+to+the+Forefront+%28TBC%29&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2012-01-22&rft.volume=22&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2011.603394 L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - "30 Years of Chemometrics" T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313035136; 6117521 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Fry, Fred AU - Handy, Sara Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313035136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=%2230+Years+of+Chemometrics%22&rft.au=Fry%2C+Fred%3BHandy%2C+Sara&rft.aulast=Fry&rft.aufirst=Fred&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pharma Waters & Real-Time Analysis (TBC) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313034367; 6117393 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Riley, Bryan Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313034367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Enhanced+Early+Head+Start+with+Employment+Services%3A+42-Month+Impacts+from+the+Kansas+and+Missouri+Sites+of+the+Enhanced+Services+for+the+Hard-to-Employ+Demonstration+and+Evaluation+Project.+OPRE+Report+2012-05&rft.au=Hsueh%2C+JoAnn%3BFarrell%2C+Mary+E.&rft.aulast=Hsueh&rft.aufirst=JoAnn&rft.date=2012-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integration PAT Real-time Process Monitoring and Physicochemical Characterization for Determining the Nucleation and Growth Mechanisms during a Dynamic Pharmaceutical Co-precipitation Process: A Process QbD Case Study T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313030897; 6117601 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Case studies KW - Physicochemical properties KW - Nucleation KW - Integration KW - Pharmaceuticals KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Integration+PAT+Real-time+Process+Monitoring+and+Physicochemical+Characterization+for+Determining+the+Nucleation+and+Growth+Mechanisms+during+a+Dynamic+Pharmaceutical+Co-precipitation+Process%3A+A+Process+QbD+Case+Study&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Process-sensitive Sentinel Genes as Novel Cell Culture Comparability Metrics T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313020433; 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6117424 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Brorson, Kurt Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Bioreactors KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313020255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Bioreactor+Introduction+and+Overview&rft.au=Brorson%2C+Kurt&rft.aulast=Brorson&rft.aufirst=Kurt&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Modelling in QbD Discussions on the ICH Points to Consider - What is the role of modelling in QbD... How do we file Models... Do all models require the same amount of supporting material for filing? T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313019531; 6117414 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Chatterjee, Sharmista AU - Korakianiti, Evdokia AU - Kourti, Dora AU - Lepore, John AU - Liesum, Lorenz AU - Nasr, Moheb Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313019531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=The+Role+of+Modelling+in+QbD+Discussions+on+the+ICH+Points+to+Consider+-+What+is+the+role+of+modelling+in+QbD...+How+do+we+file+Models...+Do+all+models+require+the+same+amount+of+supporting+material+for+filing%3F&rft.au=Chatterjee%2C+Sharmista%3BKorakianiti%2C+Evdokia%3BKourti%2C+Dora%3BLepore%2C+John%3BLiesum%2C+Lorenz%3BNasr%2C+Moheb&rft.aulast=Chatterjee&rft.aufirst=Sharmista&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - ATR-TR-IR Imaging (TBA) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313004537; 6117457 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Lanzarotta, Adam Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313004537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=A+mathematical+framework+for+including+various+sources+of+variability+in+a+task-based+assessment+of+digital+breast+tomosynthesis&rft.au=Park%2C+Subok%3BBadal-Soler%2C+Andreu%3BYoung%2C+Stefano%3BMyers%2C+Kyle&rft.aulast=Park&rft.aufirst=Subok&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of Process Models with Monte Carolo Methods T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993443; 6117552 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Kauffman, John AU - Chatterjee, Sharmista AU - Geoffroy, Jean-Marie Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluation+of+Process+Models+with+Monte+Carolo+Methods&rft.au=Kauffman%2C+John%3BChatterjee%2C+Sharmista%3BGeoffroy%2C+Jean-Marie&rft.aulast=Kauffman&rft.aufirst=John&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - CDER PAT Work (TBA) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993282; 6117430 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Read, Erik Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Isolation+and+structural+characterization+of+two+tadalafil+analogs+found+in+dietary+supplements&rft.au=Toomey%2C+Valerie+M%3BLitzau%2C+Jonathan+J%3BFlurer%2C+Cheryl+L&rft.aulast=Toomey&rft.aufirst=Valerie&rft.date=2012-02-05&rft.volume=59&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2011.09.038 L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspectives on Risk Management Across the Lifecycle T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993092; 6117386 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Friedman, Rick Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Life cycle KW - Risk management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Regulatory+Perspectives+on+Risk+Management+Across+the+Lifecycle&rft.au=Friedman%2C+Rick&rft.aulast=Friedman&rft.aufirst=Rick&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PAT/RTR: Regulatory Perspective (TBC) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312992971; 6117383 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Shah, Vibhakar Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=PAT%2FRTR%3A+Regulatory+Perspective+%28TBC%29&rft.au=Shah%2C+Vibhakar&rft.aulast=Shah&rft.aufirst=Vibhakar&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Regulatory Perspective on NIR Method Robustness T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312969717; 6117589 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Tang, Yubing Tang Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=A+Regulatory+Perspective+on+NIR+Method+Robustness&rft.au=Tang%2C+Yubing+Tang&rft.aulast=Tang&rft.aufirst=Yubing&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluating the Sensitivity of Library-Based Spectral Correlation Methods and Their Transferability Between Different Spectrometers T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312951013; 6117558 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Rodriguez, Jason AU - Buhse, Lucinda AU - Westenberger, Benjamin AU - Kauffman, John Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Sensitivity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312951013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluating+the+Sensitivity+of+Library-Based+Spectral+Correlation+Methods+and+Their+Transferability+Between+Different+Spectrometers&rft.au=Rodriguez%2C+Jason%3BBuhse%2C+Lucinda%3BWestenberger%2C+Benjamin%3BKauffman%2C+John&rft.aulast=Rodriguez&rft.aufirst=Jason&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans? AN - 916518766; 22122743 AB - Around 40% of drug-induced liver injury (DILI) cases are not detected in preclinical studies using the conventional indicators. It has been hypothesized that genomic biomarkers will be more sensitive than conventional markers in detecting human hepatotoxicity signals in preclinical studies. For example, it has been hypothesized and demonstrated in some cases that (1) genomic biomarkers from the rat liver can discriminate drug candidates that have a greater or lesser potential to cause DILI in susceptible patients despite no conventional indicators of liver toxicity being observed in preclinical studies, and (2) more sensitive biomarkers for early detection of DILI can be derived from a "subtoxic dose" at which the injury in the liver occurs at the molecular but not the phenotypic level. With a public TGx data set derived from short-term in vivo studies using rats, we divided drugs exhibiting human hepatotoxicity into three groups according to whether elevated alanine aminotransferase (ALT) or total bilirubin (TBL) were observed in the treated rats: (A) The elevation was observed in the treated rats, (B) no elevation was observed for all of the treated rats, and (C) no elevation could be observed at a lower dose and shorter duration but occur when a higher or longer treatment was applied. A control group (D) was comprised of drugs known not to cause human hepatotoxicity and for which no rats exhibited elevated ALT or TBL. We developed classifiers for groups A, B, and C against group D and found that the gene signature from scenario A could achieve 83% accuracy for human hepatotoxicity potential of drugs in a leave-one-compound-out cross-validation process, much higher than scenarios B (average 45%) and C (61%). Furthermore, the signature derived from scenario A exhibited relevance to hepatotoxicity in a pathway-based analysis and performed well on two independent public TGx data sets using different chemical treatments and profiled with different microarray platforms. Our study implied that the human hepatotoxicity potential of a drug can be reasonably assessed using TGx analysis of short-term in vivo studies only if it produces significant elevation of ALT or TBL in the treated rats. The study further revealed that the value of "sensitive" biomarkers derived from scenario C was not promising as expected for DILI assessment using the reported TGx design. The study will facilitate further research to understand the role of genomic biomarkers from rats for assessing human hepatotoxicity. JF - Chemical research in toxicology AU - Zhang, Min AU - Chen, Minjun AU - Tong, Weida AD - Center of Excellence for Bioinformatics, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2012/01/13/ PY - 2012 DA - 2012 Jan 13 SP - 122 EP - 129 VL - 25 IS - 1 KW - Biomarkers KW - 0 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Toxicogenetics KW - Disease Models, Animal KW - Biomarkers -- metabolism KW - Models, Biological KW - Bilirubin -- metabolism KW - Chemical and Drug Induced Liver Injury -- genetics KW - Alanine Transaminase -- metabolism KW - Gene Expression KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916518766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Is+toxicogenomics+a+more+reliable+and+sensitive+biomarker+than+conventional+indicators+from+rats+to+predict+drug-induced+liver+injury+in+humans%3F&rft.au=Zhang%2C+Min%3BChen%2C+Minjun%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Min&rft.date=2012-01-13&rft.volume=25&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200320e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-01 N1 - Date created - 2012-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200320e ER - TY - JOUR T1 - A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods AN - 1635018332; 16257811 AB - A new analytical method was developed to determine the presence of six (6) compounds with the potential to be used in economic adulteration to enhance the nitrogen content in milk products and bulk proteins. Residues were extracted from the matrix with 2% formic acid, after which acetonitrile (ACN) was added to induce precipitation of the proteins. Extracts were analyzed by liquid chromatography using a ZIC-HILIC column with tandem mass spectrometry (LC-MS/MS) using electrospray ionization (ESI). Single-laboratory method validation data was collected in six matrices fortified at concentrations down to 1.0 mu g/g (ppm). Average recoveries and average relative standard deviations (RSD) using spiked matrix calibration standard curves were the following: cyromazine (CY) 95.9% (7.5% RSD), dicyandiamide (DC) 98.1% (5.6% RSD), urea 102.5% (8.6% RSD), biuret (BU) 97.2% (6.6% RSD), triuret (TU) 97.7% (5.7% RSD), and amidinourea (AU) 93.4% (7.4% RSD). This method provides a rapid and effective approach to proactively combat economically motivated adulteration in protein-containing products. JF - Journal of Chromatography A AU - MacMahon, Shaun AU - Begley, Timothy H AU - Diachenko, Gregory W AU - Stromgren, Selen A AD - United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA, shaun.macmahon@fda.hhs.gov Y1 - 2012/01/13/ PY - 2012 DA - 2012 Jan 13 SP - 101 EP - 107 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1220 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Melamine KW - Economic adulteration KW - Mass spectrometry KW - Protein KW - Molecular structure KW - Mass Spectrometry KW - Ureas KW - Chromatographic techniques KW - Precipitation KW - Mass spectroscopy KW - Methodology KW - Foods KW - Calibrations KW - Standard Deviation KW - Proteins KW - Standards KW - Nitrogen KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635018332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=A+liquid+chromatography-tandem+mass+spectrometry+method+for+the+detection+of+economically+motivated+adulteration+in+protein-containing+foods&rft.au=MacMahon%2C+Shaun%3BBegley%2C+Timothy+H%3BDiachenko%2C+Gregory+W%3BStromgren%2C+Selen+A&rft.aulast=MacMahon&rft.aufirst=Shaun&rft.date=2012-01-13&rft.volume=1220&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.11.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Molecular structure; Chromatographic techniques; Mass spectroscopy; Methodology; Mass Spectrometry; Foods; Standard Deviation; Calibrations; Ureas; Proteins; Standards; Precipitation; Nitrogen DO - http://dx.doi.org/10.1016/j.chroma.2011.11.066 ER - TY - JOUR T1 - FDA Limits Use Of Cephalosporin In Food Animals AN - 914479416 AB - USDA's Food and Drug Administration (FDA) this week prohibited certain uses of cephalosporin antibiotics in animals. The move, FDA says, is aimed at preventing antibiotic resistance and preserving the drug's effectiveness for treating human diseases. The new FDA order, which takes effect April 5, applies to off-label or unapproved use of cephalosporins in major food-producing animals: cattle, swine, chickens, and turkeys. Mike Apley, DVM and a professor in Kansas State University's Department of Veterinary Clinical Sciences, as well as director of the PharmCATS Bioanalytical Laboratory, characterizes the change as "moderate." "For beef cattle, what it does is remove the ability to alter regimen but we can still use it for label application and other applications other than on the label when we meet the AMDUCA requirements, just as always. Basically what it does is stipulate that we can't alter the dose regimen and we can't use these products off label for the prevention of disease. We're still trying to get our mind around what fits that definition. Does that include the use of Ceftiofur (marketed by Pfizer as NaxcelTM, ExcenelTM and ExcedeTM) following a surgery? That might be one place where we will have an alteration on use. In addition, the rule stipulates that we can't use human cephalosporins in cattle production, which would be a rare occurrence in my opinion already," he says. JF - Beef AU - FDA release AU - Roybal, Joe Y1 - 2012/01/06/ PY - 2012 DA - 2012 Jan 06 CY - Minneapolis PB - Penton Media, Inc., Penton Business Media, Inc. SN - 00057738 KW - Agriculture--Poultry And Livestock UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914479416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabitrade&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Beef&rft.atitle=FDA+Limits+Use+Of+Cephalosporin+In+Food+Animals&rft.au=FDA+release%3BRoybal%2C+Joe&rft.aulast=FDA+release&rft.aufirst=&rft.date=2012-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Beef&rft.issn=00057738&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright Penton Business Media, Inc. and Penton Media, Inc. Jan 6, 2012 N1 - Last updated - 2012-01-07 ER - TY - JOUR T1 - Pre- and Postnatal Polychlorinated Biphenyl Concentrations and Longitudinal Measures of Thymus Volume in Infants AN - 1017976399; 16725627 AB - Background: Previously, we reported an association between higher maternal polychlorinated biphenyl (PCB) concentrations and smaller thymus volume in newborns in a birth cohort residing in eastern Slovakia. Objective: In the present report we address whether thymus volume at later ages is influenced by prenatal and early postnatal PCB exposure. Methods: At the time of delivery, 1,134 mother-infant pairs were enrolled. Maternal and 6- and 16-month infant blood samples were collected and analyzed for 15 PCB congeners. Thymus volume was measured in infants shortly after birth and at ages 6 and 16 months using ultrasonography. Results: Higher maternal PCB concentration was associated with reduced thymus volume at birth [a 0.21 SD reduction in thymus volume for an increase in total maternal PCB concentration from the 10th to the 90th percentile; 95% confidence interval (CI): -0.37, -0.05], whereas maternal PCB concentration was not predictive of 6- and 16-month thymus volume. Six-month infant PCB concentration was associated with a 0.40 SD decrease in 6-month thymus volume (95% CI: -0.76, -0.04). There was also some suggestion that thymus volume at 16 months was positively associated with concurrent infant PCB concentration. Conclusions: The potential adverse effects of in utero PCB exposure on thymic development may extend beyond the neonatal period. Results from this highly exposed cohort provide suggestive evidence that postnatal PCB concentrations may be influential, but a smaller set of 6-month PCB measurements limited statistical power at that time point. Implications regarding impaired immunologic maturation or long-term clinical implications remain to be determined. JF - Environmental Health Perspectives AU - Jusko, Todd A AU - Sonneborn, Dean AU - Palkovicova, Lubica AU - Kocan, Anton AU - Drobna, Beata AU - Trnovec, Tomas AU - Hertz-Picciotto, Irva AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2012/01/03/ PY - 2012 DA - 2012 Jan 03 SP - 595 EP - 600 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 4 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Environment Abstracts KW - atrophy KW - cohort KW - epidemiology KW - immune KW - Roma KW - T cell KW - Age KW - Slovakia KW - Statistics KW - Prenatal experience KW - Thymus KW - Intrauterine exposure KW - Ultrasonography KW - prenatal experience KW - Bioaccumulation KW - polychlorinated biphenyls KW - Congeners KW - Neonates KW - PCB compounds KW - PCB KW - Side effects KW - Infants KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017976399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Pre-+and+Postnatal+Polychlorinated+Biphenyl+Concentrations+and+Longitudinal+Measures+of+Thymus+Volume+in+Infants&rft.au=Jusko%2C+Todd+A%3BSonneborn%2C+Dean%3BPalkovicova%2C+Lubica%3BKocan%2C+Anton%3BDrobna%2C+Beata%3BTrnovec%2C+Tomas%3BHertz-Picciotto%2C+Irva&rft.aulast=Jusko&rft.aufirst=Todd&rft.date=2012-01-03&rft.volume=120&rft.issue=4&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1104229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Prenatal experience; Statistics; polychlorinated biphenyls; Thymus; Congeners; Intrauterine exposure; Neonates; Ultrasonography; Side effects; PCB; Infants; prenatal experience; Bioaccumulation; PCB compounds; Slovakia DO - http://dx.doi.org/10.1289/ehp.1104229 ER - TY - JOUR T1 - Intelligence and past use of recreational drugs AN - 964270629; 201207645 AB - One motivation for trying recreational drugs is the desire for novel experiences. More intelligent people tend to value novelty more highly and may therefore be more likely to have tried recreational drugs. Using data from a national survey, it is shown that intelligence tends to be positively related to the probabilities of having tried alcohol, marijuana, cocaine and several other recreational drugs. Evidence is also presented that those relationships typically disappear or change sign at high levels of intelligence. These patterns persist after accounting for a wide range of personal characteristics. [Copyright Elsevier Inc.] JF - Intelligence AU - Wilmoth, Daniel R AD - Cornell University, Department of Economics, Uris Hall 4th Floor, Ithaca, NY 14853, USA daniel.wilmoth@fda.hhs.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 15 EP - 22 PB - Elsevier, Amsterdam The Netherlands VL - 40 IS - 1 SN - 0160-2896, 0160-2896 KW - Intelligence Alcohol Drugs KW - Desire KW - Intelligence KW - Motivation KW - Cannabis KW - Accounting KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964270629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intelligence&rft.atitle=Intelligence+and+past+use+of+recreational+drugs&rft.au=Wilmoth%2C+Daniel+R&rft.aulast=Wilmoth&rft.aufirst=Daniel&rft.date=2012-01-01&rft.volume=40&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Intelligence&rft.issn=01602896&rft_id=info:doi/10.1016%2Fj.intell.2011.10.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NTLLDT N1 - SubjectsTermNotLitGenreText - Intelligence; Substance abuse; Cannabis; Accounting; Desire; Motivation DO - http://dx.doi.org/10.1016/j.intell.2011.10.005 ER - TY - JOUR T1 - Let The Data Be Our Guide: Trends And Tools For Research On Health Care Utilization AN - 964269352; 201206403 AB - Although consensus has yet to emerge about the appropriate framework and acceptable measures of efficiency, the AHRQ's HCUP databases and its annual quality and disparities reports are tools that researchers and policy analysts can use to understand healthcare inefficiency on a broad scale and then drill down into specifics. Clinicians can use them to understand how their practice patterns compare with national trends. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Clancy, Carolyn M AD - Agency for Healthcare Research and Quality (AHRQ), Rockville, MD USA cathy.tokarski@ahrq.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 19 EP - 23 PB - John Wiley, Chichester UK VL - 21 IS - 1 SN - 1057-9230, 1057-9230 KW - Databases KW - Health care KW - Health inequalities KW - Medical research KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964269352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Let+The+Data+Be+Our+Guide%3A+Trends+And+Tools+For+Research+On+Health+Care+Utilization&rft.au=Clancy%2C+Carolyn+M&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2012-01-01&rft.volume=21&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1809 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Health inequalities; Medical research; Databases; Helpseeking; Health care DO - http://dx.doi.org/10.1002/hec.1809 ER - TY - JOUR T1 - Emotional Relationships in Mothers and Infants: Culture-Common and Community-Specific Characteristics of Dyads From Rural and Metropolitan Settings in Argentina, Italy, and the United States AN - 964267968; 201206295 AB - This study uses country and regional contrasts to examine culture-common and community-specific variation in mother-infant emotional relationships. Altogether, 220 Argentine, Italian, and U.S. American mothers and their daughters and sons, living in rural and metropolitan settings, were observed at home at infant age 5 months. Both variable- and person-centered perspectives of dyadic emotional relationships were analyzed. Supporting the notion that adequate emotional relationships are a critical and culture-common characteristic of human infant development, across all samples most dyads scored in the adaptive range in terms of emotional relationships. Giving evidence of community-specific characteristics, Italian mothers were more sensitive, and Italian infants more responsive, than Argentine and U.S. mothers and infants; in addition, rural mothers were more intrusive than metropolitan mothers and rural dyads more likely than expected to be classified as midrange in emotional relationships and less likely to be classified as high in emotional relationships. Adaptive emotional relationships appear to be a culture-common characteristic of mother-infant dyads near the beginning of life, but this relational construct is moderated by a community-specific (country and regional) context. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Cross-Cultural Psychology AU - Bornstein, Marc H AU - Putnick, Diane L AU - Suwalsky, Joan T D AU - Venuti, Paola AU - de Falco, Simona AU - de Galperin, Celia Zingman AU - Gini, Motti AU - Tichovolsky, Marianne Heslington AD - Child & Family Research Section, National Institute of Child Health & Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 171 EP - 197 PB - Sage Publications, Thousand Oaks VL - 43 IS - 2 SN - 0022-0221, 0022-0221 KW - cultural psychology child/adolescent development social development KW - Sons KW - Daughters KW - Mothers KW - Rural communities KW - Italy KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964267968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Emotional+Relationships+in+Mothers+and+Infants%3A+Culture-Common+and+Community-Specific+Characteristics+of+Dyads+From+Rural+and+Metropolitan+Settings+in+Argentina%2C+Italy%2C+and+the+United+States&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BSuwalsky%2C+Joan+T+D%3BVenuti%2C+Paola%3Bde+Falco%2C+Simona%3Bde+Galperin%2C+Celia+Zingman%3BGini%2C+Motti%3BTichovolsky%2C+Marianne+Heslington&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2012-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - Mothers; Infants; Rural communities; Italy; Daughters; Sons DO - http://dx.doi.org/10.1177/0022022110388563 ER - TY - JOUR T1 - Evaluating portable infrared spectrometers for measuring the silica content of coal dust AN - 954647774; 16404346 AB - Miners face a variety of respiratory hazards while on the job, including exposure to silica dust which can lead to silicosis, a potentially fatal lung disease. Currently, field-collected filter samples of silica are sent for laboratory analysis and the results take weeks to be reported. Since the mining workplace is constantly moving into new and often different geological strata with changing silica levels, more timely data on silica levels in mining workplaces could help reduce exposures. Improvements in infrared (IR) spectroscopy open the prospect for end-of-shift silica measurements at mine sites. Two field-portable IR spectrometers were evaluated for their ability to quantify the mass of silica on filter samples loaded with known amounts of either silica or silica-bearing coal dust (silica content ranging from 10-200 mu g/filter). Analyses included a scheme to correct for the presence of kaolin, which is a confounder for IR analysis of silica. IR measurements of the samples were compared to parallel measurements derived using the laboratory-based U.S. Mine Safety and Health Administration P7 analytical method. Linear correlations between Fourier transform infrared (FTIR) and P7 data yielded slopes in the range of 0.90-0.97 with minimal bias. Data from a variable filter array spectrometer did not correlate as well, mainly due to poor wavelength resolution compared to the FTIR instrument. This work has shown that FTIR spectrometry has the potential to reasonably estimate the silica exposure of miners if employed in an end-of-shift method. JF - Journal of Environmental Monitoring AU - Miller, AL AU - Drake, P L AU - Murphy, N C AU - Noll, J D AU - Volkwein, J C AD - National Institute for Occupational Safety and Health, 315 E. Montgomery Ave, Spokane, WA, 99207, USA, ALMiller@cdc.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 48 EP - 55 VL - 14 IS - 1 SN - 1464-0325, 1464-0325 KW - Environment Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Filters KW - USA KW - Fourier transforms KW - Safety regulations KW - silica KW - Occupational safety KW - Coal KW - Mining KW - Dust KW - Spectrometry KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954647774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Evaluating+portable+infrared+spectrometers+for+measuring+the+silica+content+of+coal+dust&rft.au=Miller%2C+AL%3BDrake%2C+P+L%3BMurphy%2C+N+C%3BNoll%2C+J+D%3BVolkwein%2C+J+C&rft.aulast=Miller&rft.aufirst=AL&rft.date=2012-01-01&rft.volume=127&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Engineering+Geology&rft.issn=00137952&rft_id=info:doi/10.1016%2Fj.enggeo.2012.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Filters; Safety regulations; Fourier transforms; silica; Occupational safety; Mining; Coal; Dust; Spectrometry; USA DO - http://dx.doi.org/10.1039/c1em10678c ER - TY - JOUR T1 - Establishing the carcinogenic risk of immunomodulatory drugs. AN - 934266552; 22105649 AB - The first effective immunosuppressive drug (ISD) was azathioprine, approved in 1968. Early experience with this drug suggested that patients might have an excess risk of tumors including lymphoma and skin tumors. Comparison among various registries has shown that the cumulative risk of tumors increases over time. The risk is additionally increased by the more intense immunosuppressive regimens needed for lung or heart-lung transplants. The link between immunosuppression and tumorigenesis was further reinforced by the high concordance of tumor types between transplant and HIV patients. The role of the immune system in tumor defense includes both direct tumor surveillance and immunity against oncogenic viruses. In transplant patients, at least two-thirds of the lymphomas are Epstein-Barr virus (EBV)-positive. Existing methods of testing for carcinogenicity are not considered adequate to identify the hazard of tumorigenesis due to these drugs. Research is ongoing in Food and Drug Administration laboratories and at collaborators' laboratories to evaluate experimental systems that may have the ability to adequately identify this class of hazard. Initial work is on various model systems similar to EBV. These include the MHV-68 mouse model, lymphocryptovirus (LCV-1) in the cynomolgus monkey, and preliminary work with mice with humanized immune systems using EBV directly. JF - Toxicologic pathology AU - Weaver, James L AD - Division of Drug Safety Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. james.weaver@fda.hhs.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 267 EP - 271 VL - 40 IS - 2 KW - Immunologic Factors KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Drug Evaluation -- methods KW - Immunologic Factors -- immunology KW - Neoplasms -- chemically induced KW - Neoplasms -- immunology KW - Immunologic Factors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/934266552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Establishing+the+carcinogenic+risk+of+immunomodulatory+drugs.&rft.au=Weaver%2C+James+L&rft.aulast=Weaver&rft.aufirst=James&rft.date=2012-01-01&rft.volume=40&rft.issue=2&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623311427711 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-08-30 N1 - Date created - 2012-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623311427711 ER - TY - JOUR T1 - Occupational Injuries, Illnesses, and Fatalities Among Workers in the Services Sector Industries 2003 to 2007 AN - 926891586; 16292450 AB - Objective: Provide descriptive statistics and discuss priorities for injury and fatality risks among services sector workers. Methods: Bureau of Labor Statistics Survey of Occupational Injuries and Illnesses and Census of Fatal Occupational Injuries data for 2003 to 2007 were analyzed to identify occupational injury and fatality risks for services sector industry groups. Results: Many services sector industry groups experienced, on average, greater than one occupational fatality per week, and survey of occupational injuries and illnesses days-away-from-work rates in excess of those for all US workers. Overall, transportation incidents and homicides are leading factors contributing to fatalities. Conclusions: These results indicate the need for adoption of safety and health prevention practices in numerous industry groups. For groups that experience elevated injury and fatality rates, priorities for research and intervention can be identified through these data. JF - Journal of Occupational and Environmental Medicine AU - Utterback, D F AU - Charles, LE AU - Schnorr, T M AU - Tiesman, H M AU - Storey, E AU - Vossenas, P AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, dutterback@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 31 EP - 41 VL - 54 IS - 1 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Mortality KW - Occupational safety KW - Transportation KW - census KW - homicide KW - intervention KW - prevention KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Injuries%2C+Illnesses%2C+and+Fatalities+Among+Workers+in+the+Services+Sector+Industries+2003+to+2007&rft.au=Utterback%2C+D+F%3BCharles%2C+LE%3BSchnorr%2C+T+M%3BTiesman%2C+H+M%3BStorey%2C+E%3BVossenas%2C+P&rft.aulast=Utterback&rft.aufirst=D&rft.date=2012-01-01&rft.volume=55&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - census; Mortality; homicide; Transportation; Injuries; intervention; Occupational safety; prevention DO - http://dx.doi.org/10.1097/JOM.0b013e3182398e36 ER - TY - JOUR T1 - Association of overtime work with cellular immune markers among healthy daytime white-collar employees AN - 920803642; 16281334 AB - Objective Even though overtime work has been suspected to be a risk factor for ill health, little research has been done to determine the underlying immunological mechanisms. This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. Methods A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women), aged 22-69 (mean 36) years, provided a blood sample for the measurement of circulating immune [natural killer (NK), B, and T] cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey including overtime/month. Blood samples were collected between 09.00-11.00 hours during working days and participants completed the questionnaire within the two weeks prior to the blood sampling. Stepwise linear regression analyses controlling for confounders were carried out to examine the relationship between overtime work and immune markers. Results Overtime work was mainly related to short sleep duration, increased weight, and reduced job satisfaction, and it was more prevalent among men than women and among younger and married employees. Amount of overtime was inversely associated with NK (CD3-CD56+) cell counts (ss=-0.145; P =0.032) but was not associated with NKCC, NKCC/NK cell ratio, or T or B cells. Conclusions The NK cell is a lymphocyte that possesses killer activity against tumor and virus-infected cells and constitutes a major component of the innate immune system. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense. However, the finding needs to be further validated with a well-designed study using objective overtime measures. JF - Scandinavian Journal of Work, Environment & Health AU - Nakata, A AU - Takahashi, M AU - Irie, M AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226, USA, cji5@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 56 EP - 64 VL - 38 IS - 1 SN - 0355-3140, 0355-3140 KW - Immunology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Inventories KW - immune system KW - Lymphocytes B KW - Immune system KW - Natural killer cells KW - tumors KW - Lymphocytes KW - Tumors KW - Cytotoxicity KW - Daytime KW - Immunity (cell-mediated) KW - Sleep KW - Risk factors KW - Lymphocytes T KW - Regression analysis KW - Sampling KW - Japan KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920803642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Association+of+overtime+work+with+cellular+immune+markers+among+healthy+daytime+white-collar+employees&rft.au=Nakata%2C+A%3BTakahashi%2C+M%3BIrie%2C+M&rft.aulast=Nakata&rft.aufirst=A&rft.date=2012-01-01&rft.volume=38&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Inventories; Lymphocytes B; Immune system; Natural killer cells; Tumors; Cytotoxicity; Daytime; Immunity (cell-mediated); Risk factors; Sleep; Regression analysis; Lymphocytes T; Sampling; immune system; tumors; Lymphocytes; Japan DO - http://dx.doi.org/10.5271/sjweh.3183 ER - TY - JOUR T1 - Improvement of a mine fire simulation program - incorporation of smoke rollback into MFIRE 3.0 AN - 920792575; 16209844 AB - Smoke rollback is a dangerous threat to miners and firefighters in an underground mine fire. The ability to predict smoke rollback can greatly improve the chances for safe miner evacuation and mine fire control and firefighting. A modified semi-empirical equation based on large-scale experiments conducted by the National Institute for Occupational Safety and Health (NIOSH) was developed to quantify smoke rollback during an underground mine fire. The equation was incorporated into a mine fire simulation program (MFIRE 3.0) to allow the user to predict the occurrence of smoke rollback and calculate the smoke rollback distance. This article describes the development of the equation and compares the experimental results with those predicted by MFIRE 3.0. The results indicate that the improved MFIRE 3.0 is capable of determining smoke rollback in a fire entry, not only to provide early warning for smoke rollback but also to verify the effectiveness of smoke rollback control efforts. JF - Journal of Fire Sciences AU - Zhou, Lihong AU - Smith, Alex C AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, PA, itn2@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 29 EP - 39 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 30 IS - 1 SN - 0734-9041, 0734-9041 KW - Health & Safety Science Abstracts KW - coal mine fire KW - mine fire simulation KW - smoke rollback KW - Smoke KW - Fires KW - firefighter services KW - Occupational safety KW - Simulation KW - Mining KW - Mines KW - evacuation KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fire+Sciences&rft.atitle=Improvement+of+a+mine+fire+simulation+program+-+incorporation+of+smoke+rollback+into+MFIRE+3.0&rft.au=Zhou%2C+Lihong%3BSmith%2C+Alex+C&rft.aulast=Zhou&rft.aufirst=Lihong&rft.date=2012-01-01&rft.volume=30&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fire+Sciences&rft.issn=07349041&rft_id=info:doi/10.1177%2F0734904111418483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Number of references - 17 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Smoke; Fires; firefighter services; Occupational safety; Simulation; Mining; Mines; evacuation DO - http://dx.doi.org/10.1177/0734904111418483 ER - TY - JOUR T1 - Molecular characterization of strains of fluoroquinolone-resistant Salmonella enterica serovar Schwarzengrund carrying multidrug resistance isolated from imported foods AN - 920788524; 16180635 AB - Objectives To determine the fluoroquinolone resistance determinants in Salmonella enterica serovar Schwarzengrund from imported foods. Methods Antibiotic susceptibility of Salmonella Schwarzengrund to 16 antibiotics was examined using disc agar diffusion and Etest. Quinolone resistance determinants were examined by sequence analysis of gyrA, gyrB, parC and parE, PCR amplification of qnrA, qnrB and qnrS, and expression of acrB, ramA, marA, soxS and rob using quantitative RT-PCR. The contribution of efflux pump activities to antibiotic resistance was determined by the addition of carbonyl cyanide m-chlorophenylhydrazone (CCCP). The effect of ramR deletion on ciprofloxacin resistance was determined by complementing with wild-type ramR. Results Salmonella strains 30 and 487 were susceptible to ciprofloxacin and had a single mutation in gyrA as compared with strain 75, which was highly resistant to ciprofloxacin and had a double mutation in gyrA. Increased expression of ramA was associated with high resistance to ciprofloxacin. Strain 75 had a deletion of 315 bp in the ramR gene, which regulates ramA expression. Overexpression of ramA was possibly related to a loss of ramR. Introduction of ramR decreased the MIC of ciprofloxacin from 48 to 24 mg/L. The addition of CCCP did not reduce antibiotic resistance. To our knowledge, this study reports for the first time the natural deletion of ramR in Salmonella Schwarzengrund. Conclusions This study indicates that fluoroquinolone-resistant Salmonella are prevalent in imported food. Double mutations in gyrA and a loss of ramR were associated with high-level quinolone resistance in multidrug-resistant Salmonella Schwarzengrund strain 75. JF - Journal of Antimicrobial Chemotherapy AU - Akiyama, Tatsuya AU - Khan, Ashraf A AD - Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA, ashraf.khan@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 101 EP - 110 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 67 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Fluoroquinolones KW - Drug resistance KW - Food KW - Quinolones KW - DNA topoisomerase KW - Antibiotics KW - Minimum inhibitory concentration KW - DNA topoisomerase IV KW - Ciprofloxacin KW - Gene deletion KW - Cyanide KW - Salmonella enterica KW - Polymerase chain reaction KW - Diffusion KW - Multidrug resistance KW - Mutation KW - carbonyls KW - Antibiotic resistance KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920788524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Molecular+characterization+of+strains+of+fluoroquinolone-resistant+Salmonella+enterica+serovar+Schwarzengrund+carrying+multidrug+resistance+isolated+from+imported+foods&rft.au=Akiyama%2C+Tatsuya%3BKhan%2C+Ashraf+A&rft.aulast=Akiyama&rft.aufirst=Tatsuya&rft.date=2012-01-01&rft.volume=67&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkr414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Agar; Fluoroquinolones; Food; Drug resistance; Quinolones; DNA topoisomerase; Antibiotics; Minimum inhibitory concentration; DNA topoisomerase IV; Ciprofloxacin; Gene deletion; Cyanide; Polymerase chain reaction; Multidrug resistance; Diffusion; carbonyls; Mutation; Antibiotic resistance; Salmonella enterica DO - http://dx.doi.org/10.1093/jac/dkr414 ER - TY - JOUR T1 - RNA polymerase beta subunit (rpoB) gene and the 16S-23S rRNA intergenic transcribed spacer region (ITS) as complementary molecular markers in addition to the 16S rRNA gene for phylogenetic analysis and identification of the species of the family Mycoplasmataceae AN - 918054948; 16181184 AB - Conventional classification of the species in the family Mycoplasmataceae is mainly based on phenotypic criteria, which are complicated, can be difficult to measure, and have the potential to be hampered by phenotypic deviations among the isolates. The number of biochemical reactions suitable for phenotypic characterization of the Mycoplasmataceae is also very limited and therefore the strategy for the final identification of the Mycoplasmataceae species is based on comparative serological results. However, serological testing of the Mycoplasmataceae species requires a performance panel of hyperimmune sera which contains anti-serum to each known species of the family, a high level of technical expertise, and can only be properly performed by mycoplasma-reference laboratories. In addition, the existence of uncultivated and fastidious Mycoplasmataceae species/isolates in clinical materials significantly complicates, or even makes impossible, the application of conventional bacteriological tests. The analysis of available genetic markers is an additional approach for the primary identification and phylogenetic classification of cultivable species and uncultivable or fastidious organisms in standard microbiological laboratories. The partial nucleotide sequences of the RNA polymerase beta -subunit gene (rpoB) and the 16S-23S rRNA intergenic transcribed spacer (ITS) were determined for all known type strains and the available non-type strains of the Mycoplasmataceae species. In addition to the available 16S rRNA gene data, the ITS and rpoB sequences were used to infer phylogenetic relationships among these species and to enable identification of the Mycoplasmataceae isolates to the species level. The comparison of the ITS and rpoB phylogenetic trees with the 16S rRNA reference phylogenetic tree revealed a similar clustering patterns for the Mycoplasmataceae species, with minor discrepancies for a few species that demonstrated higher divergence of their ITS and rpoB in comparison to their neighbor species. Overall, our results demonstrated that the ITS and rpoB gene could be useful complementary phylogenetic markers to infer phylogenetic relationships among the Mycoplasmataceae species and provide useful background information for the choice of appropriate metabolic and serological tests for the final classification of isolates. In summary, three-target sequence analysis, which includes the ITS, rpoB, and 16S rRNA genes, was demonstrated to be a reliable and useful taxonomic tool for the species differentiation within the family Mycoplasmataceae based on their phylogenetic relatedness and pairwise sequence similarities. We believe that this approach might also become a valuable tool for routine analysis and primary identification of new isolates in medical and veterinary microbiological laboratories. JF - Molecular Phylogenetics and Evolution AU - Volokhov, Dmitriy V AU - Simonyan, Vahan AU - Davidson, Maureen K AU - Chizhikov, Vladimir E AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, United States, dmitriy.volokhov@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 515 EP - 528 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 62 IS - 1 SN - 1055-7903, 1055-7903 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Mycoplasmas KW - Phylogeny KW - Bacteria KW - rpoB KW - 16S rRNA KW - rRNA KW - Differentiation KW - DNA-directed RNA polymerase KW - Spacer region KW - Data processing KW - Classification KW - Genetic markers KW - Serological tests KW - rRNA 16S KW - RpoB protein KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918054948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Phylogenetics+and+Evolution&rft.atitle=Lactobacillus+acidophilus+and+Lactobacillus+reuteri+modulate+cytokine+responses+in+gnotobiotic+pigs+infected+with+human+rotavirus.&rft.au=Azevedo%2C+M+S+P%3BZhang%2C+W%3BWen%2C+K%3BGonzalez%2C+A+M%3BSaif%2C+L+J%3BYousef%2C+A+E%3BYuan%2C+L&rft.aulast=Azevedo&rft.aufirst=M+S&rft.date=2012-03-01&rft.volume=3&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Beneficial+microbes&rft.issn=1876-2891&rft_id=info:doi/10.3920%2FBM2011.0041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Phylogeny; Differentiation; rRNA; Spacer region; DNA-directed RNA polymerase; Data processing; Classification; Genetic markers; Serological tests; rRNA 16S; RpoB protein DO - http://dx.doi.org/10.1016/j.ympev.2011.11.002 ER - TY - JOUR T1 - Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood. AN - 916145249; 22017681 AB - Puberty is an important transition that enables reproduction of mammalian species. Precocious puberty, specifically early thelarche (the appearance of breast "buds"), in girls of multiple ethnic backgrounds is a major health problem in the United States and other countries. The cause for a continued decrease in the age of breast development in girls is unknown, but environmental factors likely play a major role. Laboratory and epidemiological studies have identified several individual environmental factors that affect breast development, but further progress is needed. Current research needs include increased attention to and recording of prenatal and neonatal environmental exposures, testing of marketed chemicals for effects on the mammary gland, and understanding of the mammary gland-specific mechanisms that are altered by chemicals. Such research is required to halt the increasing trend toward puberty at earlier ages. JF - Annual review of pharmacology and toxicology AU - Fenton, Suzanne E AU - Reed, Casey AU - Newbold, Retha R AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. fentonse@niehs.nih.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 455 EP - 479 VL - 52 KW - Endocrine Disruptors KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - United States KW - Animals KW - Environmental Pollutants -- toxicity KW - Perinatal Care KW - Reproduction -- drug effects KW - Puberty -- drug effects KW - Humans KW - Rodentia -- growth & development KW - Puberty, Precocious -- pathology KW - Body Weight KW - Endocrine Disruptors -- toxicity KW - Puberty, Precocious -- chemically induced KW - Risk Factors KW - Puberty -- physiology KW - Diet KW - Female KW - Environmental Exposure -- analysis KW - Breast -- drug effects KW - Breast -- pathology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916145249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+pharmacology+and+toxicology&rft.atitle=%28Q%29SAR+modeling+and+safety+assessment+in+regulatory+review.&rft.au=Kruhlak%2C+N+L%3BBenz%2C+R+D%3BZhou%2C+H%3BColatsky%2C+T+J&rft.aulast=Kruhlak&rft.aufirst=N&rft.date=2012-03-01&rft.volume=91&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2011.300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-03 N1 - Date created - 2012-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Endocrinol. 2010 Jan 27;314(2):164-9 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Apr 1;36(7):1414-8 [11999045] Clin Endocrinol (Oxf). 2002 Jul;57(1):101-6 [12100077] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Toxicology. 2002 Aug 15;177(2-3):197-205 [12135623] Environ Health Perspect. 2002 Aug;110(8):771-6 [12153757] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev-pharmtox-010611-134659 ER - TY - JOUR T1 - Comparison of the effects of antimicrobial agents from three different classes on metabolism of isoflavonoids by colonic microflora using Etest strips. AN - 913317987; 22006071 AB - Daidzein (4',7-dihydroxyisoflavone), a phytoestrogen found in soybeans mainly in the form of its glycoside daidzin, is metabolized by colonic bacteria to compounds with altered estrogenic activities, which may affect human health. Antibacterial agents used for the treatment of infections can alter the composition of bacterial populations in the colon and therefore can affect daidzein metabolism. To rapidly detect the effects of different concentrations of antibiotics on daidzein metabolism by colonic bacteria of monkeys and identify the subpopulation involved in daidzein metabolism, Etest strips containing antibacterial agents from three classes (tetracyclines, fluoroquinolones, and β-lactams) were used to eliminate the colonic bacteria that were susceptible to 0-32 μg/ml of each antibacterial agent and test the surviving bacteria for their ability to metabolize daidzein. The metabolism of daidzein by the colonic microflora was measured before and after the colonic bacterial population was exposed to antibacterial agents. The metabolites were detected by high performance liquid chromatography and mass spectrometry after incubation of the cultures for various times. Exposure of colonic microflora to antibiotics had various effects on daidzein metabolism. Tetracycline completely removed the bacteria metabolizing daidzein, metabolism of daidzein was not changed in cultures of bacteria after ceftriaxone treatment, and ciprofloxacin enriched for the bacteria metabolizing daidzein. In liquid cultures treated with various concentrations of ciprofloxacin, 4 μg/ml of ciprofloxacin favored the growth of bacteria that metabolized daidzein. This is the first time in which the Etest has been used to show that, whereas some antibiotics eliminate phytoestrogen-metabolizing bacteria in colonic microflora, others enrich them by eliminating the non-metabolizing strains in the population. JF - Current microbiology AU - Sutherland, John B AU - Bridges, Brad M AU - Heinze, Thomas M AU - Adams, Michael R AU - Delio, Patrick J AU - Hotchkiss, Charlotte AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 60 EP - 65 VL - 64 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Isoflavones KW - beta-Lactams KW - daidzin KW - 4R2X91A5M5 KW - Tetracycline KW - F8VB5M810T KW - Index Medicus KW - Feces -- microbiology KW - Animals KW - Macaca fascicularis KW - Microbial Sensitivity Tests -- instrumentation KW - Humans KW - beta-Lactams -- pharmacology KW - Fluoroquinolones -- pharmacology KW - Tetracycline -- pharmacology KW - Bacteria -- metabolism KW - Colon -- metabolism KW - Colon -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Bacteria -- isolation & purification KW - Bacteria -- drug effects KW - Isoflavones -- metabolism KW - Colon -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913317987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+microbiology&rft.atitle=Comparison+of+the+effects+of+antimicrobial+agents+from+three+different+classes+on+metabolism+of+isoflavonoids+by+colonic+microflora+using+Etest+strips.&rft.au=Sutherland%2C+John+B%3BBridges%2C+Brad+M%3BHeinze%2C+Thomas+M%3BAdams%2C+Michael+R%3BDelio%2C+Patrick+J%3BHotchkiss%2C+Charlotte%3BRafii%2C+Fatemeh&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2012-01-01&rft.volume=64&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Current+microbiology&rft.issn=1432-0991&rft_id=info:doi/10.1007%2Fs00284-011-0020-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00284-011-0020-4 ER - TY - JOUR T1 - Toxicological significance of azo dye metabolism by human intestinal microbiota. AN - 913032652; 22201895 AB - Approximately 0.7 million tons of azo dyes are synthesized each year. Azo dyes are composed of one or more R₁-N=N-R₂ linkages. Studies have shown that both mammalian and microbial azoreductases cleave the azo bonds of the dyes to form compounds that are potentially genotoxic. The human gastrointestinal tract harbors a diverse microbiota comprised of at least several thousand species. Both water-soluble and water-insoluble azo dyes can be reduced by intestinal bacteria. Some of the metabolites produced by intestinal microbiota have been shown to be carcinogenic to humans although the parent azo dyes may not be classified as being carcinogenic. Azoreductase activity is commonly found in intestinal bacteria. Three types of azoreductases have been characterized in bacteria. They are flavin dependent NADH preferred azoreductase, flavin dependent NADPH preferred azoreductase, and flavin free NADPH preferred azoreductase. This review highlights how azo dyes are metabolized by intestinal bacteria, mechanisms of azo reduction, and the potential contribution in the carcinogenesis/mutagenesis of the reduction of the azo dyes by intestinal microbiota. JF - Frontiers in bioscience (Elite edition) AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2012/01/01/ PY - 2012 DA - 2012 Jan 01 SP - 568 EP - 586 VL - 4 KW - Azo Compounds KW - 0 KW - Carcinogens KW - Coloring Agents KW - Index Medicus KW - Carcinogens -- metabolism KW - Humans KW - Bacteria -- metabolism KW - Azo Compounds -- metabolism KW - Coloring Agents -- toxicity KW - Azo Compounds -- toxicity KW - Coloring Agents -- metabolism KW - Intestines -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913032652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Elite+edition%29&rft.atitle=Toxicological+significance+of+azo+dye+metabolism+by+human+intestinal+microbiota.&rft.au=Feng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Feng&rft.aufirst=Jinhui&rft.date=2012-01-01&rft.volume=4&rft.issue=&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Elite+edition%29&rft.issn=1945-0508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-14 N1 - Date created - 2011-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL AN - 912732734 AB - It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining <1 HIV RNA copy/mL. We therefore investigated the effect of residual viraemia on virological rebound. We used a prospective, non-interventional, single-centre, study. This analysis was based on HIV-infected patients with two consecutive HIV RNA viral loads (VLs) of <50 copies/mL as tested by Versant bDNA, followed by two HIV RNA VLs of <50 copies/mL as tested using the Versant kinetic PCR molecular system (kPCR; limit of quantification = 1 copy/mL). Virological rebound was defined as two consecutive HIV RNA values of >50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. There were 739 eligible patients; 446 (60.4%) had HIV RNA <1 copy/mL (group A) and 293 (39.6%) had residual viraemia (1-49 HIV RNA copies/mL; group B). After a follow-up (median 48.9 weeks), virological rebound occurred in four patients in group A (0.9%) and six patients in group B (2%); the time to virological rebound was similar in the two groups (log-rank test P = 0.231). CD4+ cell recovery (slope) was significantly less in the patients with residual viraemia; +14.3 (-7.7, 43.9) cells/mm... per year versus +21.2 (-2.5, 53.2) cells/mm... per year; P = 0.036. Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining <1 HIV RNA copy/mL showed a small but statistically significant improvement in CD4+ cell recovery. (ProQuest: ... denotes formulae/symbols omitted.) JF - The Journal of Antimicrobial Chemotherapy AU - Gianotti, Nicola AU - Galli, Laura AU - Racca, Sara AU - Salpietro, Stefania AU - Cossarini, Francesca AU - Spagnuolo, Vincenzo AU - Barda, Beatrice AU - Canducci, Filippo AU - Clementi, Massimo AU - Lazzarin, Adriano AU - Castagna, Antonella Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 213 CY - Oxford PB - Oxford Publishing Limited(England) VL - 67 IS - 1 SN - 03057453 KW - Pharmacy And Pharmacology KW - Human immunodeficiency virus--HIV KW - Ribonucleic acid--RNA KW - Cells KW - Bacteria KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912732734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Residual+viraemia+does+not+influence+1+year+virological+rebound+in+HIV-infected+patients+with+HIV+RNA+persistently+below+50+copies%2FmL&rft.au=Gianotti%2C+Nicola%3BGalli%2C+Laura%3BRacca%2C+Sara%3BSalpietro%2C+Stefania%3BCossarini%2C+Francesca%3BSpagnuolo%2C+Vincenzo%3BBarda%2C+Beatrice%3BCanducci%2C+Filippo%3BClementi%2C+Massimo%3BLazzarin%2C+Adriano%3BCastagna%2C+Antonella&rft.aulast=Gianotti&rft.aufirst=Nicola&rft.date=2012-01-01&rft.volume=67&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Oxford Publishing Limited(England) Jan 2012 N1 - Last updated - 2011-12-27 ER - TY - JOUR T1 - Evaluation of furfuryl alcohol sensitization potential following dermal and pulmonary exposure: enhancement of airway responsiveness. AN - 912638656; 22003193 AB - Furfuryl alcohol is considered by the U.S. Environmental Protection Agency to be a high volume production chemical, with over 1 million pounds produced annually. Due to its high production volume and its numerous industrial and consumer uses, there is considerable potential for work-related exposure, as well as exposure to the general population, through pulmonary, oral, and dermal routes of exposure. Human exposure data report a high incidence of asthma in foundry mold workers exposed to furan resins, suggesting potential immunologic effects. Although furfuryl alcohol was nominated and evaluated for its carcinogenic potential by the National Toxicology Program, studies evaluating its immunotoxicity are lacking. The studies presented here evaluated the immunotoxic potential of furfuryl alcohol following exposure by the dermal and pulmonary routes using a murine model. When tested in a combined irritancy local lymph node assay, furfuryl alcohol was identified to be an irritant and mild sensitizer (EC3 = 25.6%). Pulmonary exposure to 2% furfuryl alcohol resulted in enhanced airway hyperreactivity, eosinophilic infiltration into the lungs, and enhanced cytokine production (IL-4, IL-5, and interferon-γ) by ex vivo stimulated lung-associated draining lymphoid cells. Airway hyperreactivity and eosinophilic lung infiltration were augmented by prior dermal exposure to furfuryl alcohol. These results suggest that furfuryl alcohol may play a role in the development of allergic airway disease and encourage the need for additional investigation. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Franko, Jennifer AU - Jackson, Laurel G AU - Hubbs, Ann AU - Kashon, Michael AU - Meade, B J AU - Anderson, Stacey E AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 105 EP - 115 VL - 125 IS - 1 KW - Air Pollutants KW - 0 KW - Furans KW - Interleukin-5 KW - Interleukin-4 KW - 207137-56-2 KW - Immunoglobulin E KW - 37341-29-0 KW - Interferon-gamma KW - 82115-62-6 KW - furfuryl alcohol KW - D582054MUH KW - Index Medicus KW - Animals KW - Immunoglobulin E -- blood KW - Interleukin-4 -- immunology KW - Mice KW - Interferon-gamma -- immunology KW - Lung -- pathology KW - Mice, Inbred BALB C KW - Lymph Nodes -- cytology KW - Lung -- immunology KW - Bronchoalveolar Lavage Fluid -- immunology KW - Interleukin-5 -- immunology KW - Cells, Cultured KW - Inhalation Exposure KW - Lung -- drug effects KW - Local Lymph Node Assay KW - Lymph Nodes -- drug effects KW - Bronchoalveolar Lavage Fluid -- cytology KW - Administration, Topical KW - Female KW - Lymph Nodes -- immunology KW - Dermatitis, Allergic Contact -- immunology KW - Dermatitis, Irritant -- immunology KW - Respiratory Hypersensitivity -- etiology KW - Dermatitis, Allergic Contact -- etiology KW - Furans -- toxicity KW - Respiratory Hypersensitivity -- immunology KW - Air Pollutants -- toxicity KW - Dermatitis, Irritant -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912638656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Evaluation+of+furfuryl+alcohol+sensitization+potential+following+dermal+and+pulmonary+exposure%3A+enhancement+of+airway+responsiveness.&rft.au=Franko%2C+Jennifer%3BJackson%2C+Laurel+G%3BHubbs%2C+Ann%3BKashon%2C+Michael%3BMeade%2C+B+J%3BAnderson%2C+Stacey+E&rft.aulast=Franko&rft.aufirst=Jennifer&rft.date=2012-01-01&rft.volume=125&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr271 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-06 N1 - Date created - 2011-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr271 ER - TY - JOUR T1 - Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. AN - 912637867; 22170360 AB - The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider. In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes. Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression. Red meat intake [62.7 g (quintile 5) compared with 9.8 g (quintile 1) per 1000 kcal (median)] was associated with a tendency toward an increased risk of RCC [HR: 1.19; 95% CI: 1.01, 1.40; P-trend = 0.06] and a 2-fold increased risk of papillary RCC [P-trend = 0.002]. Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30% elevated risk of RCC and a 2-fold increased risk of papillary RCC. No associations were observed for the clear cell subtype. Red meat intake may increase the risk of RCC through mechanisms related to the cooking compounds BaP and PhIP. Our findings for RCC appeared to be driven by strong associations with the rarer papillary histologic variant. This study is registered at clinicaltrials.gov as NCT00340015. JF - The American journal of clinical nutrition AU - Daniel, Carrie R AU - Cross, Amanda J AU - Graubard, Barry I AU - Park, Yikyung AU - Ward, Mary H AU - Rothman, Nathaniel AU - Hollenbeck, Albert R AU - Chow, Wong-Ho AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD, USA. carrie.daniel@nih.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 155 EP - 162 VL - 95 IS - 1 KW - Imidazoles KW - 0 KW - Mutagens KW - Polycyclic Compounds KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Risk Factors KW - Humans KW - Incidence KW - Middle Aged KW - Benzo(a)pyrene -- adverse effects KW - Male KW - Imidazoles -- adverse effects KW - Female KW - Carcinoma, Renal Cell -- etiology KW - Meat -- adverse effects KW - Mutagens -- adverse effects KW - Cooking KW - Diet KW - Polycyclic Compounds -- adverse effects KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912637867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Large+prospective+investigation+of+meat+intake%2C+related+mutagens%2C+and+risk+of+renal+cell+carcinoma.&rft.au=Daniel%2C+Carrie+R%3BCross%2C+Amanda+J%3BGraubard%2C+Barry+I%3BPark%2C+Yikyung%3BWard%2C+Mary+H%3BRothman%2C+Nathaniel%3BHollenbeck%2C+Albert+R%3BChow%2C+Wong-Ho%3BSinha%2C+Rashmi&rft.aulast=Daniel&rft.aufirst=Carrie&rft.date=2012-01-01&rft.volume=95&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/10.3945%2Fajcn.111.019364 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-16 N1 - Date created - 2011-12-22 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00340015; ClinicalTrials.gov N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8 [14973110] Br J Cancer. 2011 Sep 27;105(7):1096-104 [21897389] Int J Cancer. 1996 Jan 3;65(1):67-73 [8543399] Princess Takamatsu Symp. 1995;23:85-92 [8844799] Cancer Epidemiol Biomarkers Prev. 1997 Apr;6(4):215-23 [9107425] Lancet. 1999 Feb 27;353(9154):703-7 [10073512] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Causes Control. 2007 Mar;18(2):125-33 [17242980] Urology. 2007 Mar;69(3):452-6 [17382143] Cancer Causes Control. 2007 Dec;18(10):1141-51 [17717631] Public Health Nutr. 2008 Feb;11(2):183-95 [17610761] Hum Pathol. 2009 Jan;40(1):10-29 [19027455] J Natl Cancer Inst. 2008 Dec 3;100(23):1695-706 [19033572] J Am Diet Assoc. 2009 Apr;109(4):656-67 [19328261] Cancer Detect Prev. 2009;32(5-6):340-51 [19303221] Am J Epidemiol. 1986 Jul;124(1):17-27 [3521261] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Int J Epidemiol. 2000 Dec;29(6):1060-4 [11101548] J Soc Biol. 2000;194(1):29-38 [11107547] Carcinogenesis. 2001 Jan;22(1):199-202 [11159760] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Epidemiology. 2001 May;12(3):327-38 [11338313] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Carcinogenesis. 2002 May;23(5):809-15 [12016154] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Redox Rep. 2002;7(4):189-97 [12396663] J Nutr. 2002 Nov;132(11 Suppl):3526S-3529S [12421882] IARC Sci Publ. 2002;156:181-6 [12484160] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Mutat Res. 2003 Dec 10;533(1-2):153-71 [14643418] Environ Mol Mutagen. 2004;43(1):53-74 [14743346] Nat Rev Urol. 2010 May;7(5):245-57 [20448658] Nat Rev Urol. 2010 May;7(5):277-85 [20448661] J Appl Toxicol. 2010 Jul;30(5):402-10 [20186696] Am J Pathol. 2011 Feb;178(2):853-60 [21281817] Comment In: J Urol. 2012 Jun;187(6):2022-3 [22579170] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3945/ajcn.111.019364 ER - TY - JOUR T1 - MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver. AN - 912107813; 21976715 AB - Pyrrolizidine alkaloids (PAs) are the most common plant constituents that poison livestock, wildlife and humans. Riddelliine is a prototype genotoxic PA and has been nominated to be classified as a reasonably anticipated human carcinogen by the US National Toxicology Program (NTP) in the 12th Report on Carcinogens. Riddelliine's nomination is due to the high incidence of liver tumours that were observed in both mice and rats in the NTP tumourigenicity bioassay study. In this current study, we explored whether riddelliine treatment could alter microRNA (miRNA) expression in rat liver and whether the possible deregulation of miRNA was related to mutagenicity and carcinogenicity of riddelliine. Groups of six rats were administered riddelliine at a mutagenic dose of 1 mg/kg body weight or with control vehicle 5 days a week for 12 weeks. A group of six rats treated with aristolochic acid, a renal carcinogen, was used as a tissue-specific negative control. The animals were sacrificed 1 day after the last treatment and the livers were isolated for miRNA expression analysis using miRNA microarrays. miRNA expression was significantly altered by riddelliine treatment. Principal component analysis and hierarchical clustering analysis showed that the miRNA expression profiles were clearly classified into two groups, riddelliine treatment versus other samples. Forty-seven miRNAs were significantly dysregulated by riddelliine treatment, among which 38 were up-regulated and 9 were down-regulated. Functional analysis of these differentially expressed miRNAs by riddelliine revealed that these miRNAs were involved in liver carcinogenicity and toxicity, such as liver proliferation, liver necrosis/cell death, hepatocellular carcinoma, liver hepatomegaly, liver inflammation and liver fibrosis. These results suggest that miRNAs actively respond to a mutagenic dose of riddelliine and the pattern of miRNA expression has the potential to be used as a biomarker of genotoxicity and carcinogenicity for riddelliine and possibly other PAs. JF - Mutagenesis AU - Chen, Tao AU - Li, Zhiguang AU - Yan, Jian AU - Yang, Xi AU - Salminen, William AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 59 EP - 66 VL - 27 IS - 1 KW - Carcinogens KW - 0 KW - MicroRNAs KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Liver -- pathology KW - Rats, Transgenic KW - Liver -- drug effects KW - Dose-Response Relationship, Drug KW - RNA -- isolation & purification KW - Microarray Analysis KW - Liver Neoplasms -- chemically induced KW - Gene Expression Regulation KW - Cluster Analysis KW - Carcinogens -- administration & dosage KW - MicroRNAs -- genetics KW - Carcinogens -- toxicity KW - Pyrrolizidine Alkaloids -- administration & dosage KW - Pyrrolizidine Alkaloids -- toxicity KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912107813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=MicroRNA+expression+profiles+distinguish+the+carcinogenic+effects+of+riddelliine+in+rat+liver.&rft.au=Chen%2C+Tao%3BLi%2C+Zhiguang%3BYan%2C+Jian%3BYang%2C+Xi%3BSalminen%2C+William&rft.aulast=Chen&rft.aufirst=Tao&rft.date=2012-01-01&rft.volume=27&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger060 ER - TY - JOUR T1 - Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions. AN - 908010042; 22130878 AB - Functional comparison across microarray platforms is used to assess the comparability or similarity of the biological relevance associated with the gene expression data generated by multiple microarray platforms. Comparisons at the functional level are very important considering that the ultimate purpose of microarray technology is to determine the biological meaning behind the gene expression changes under a specific condition, not just to generate a list of genes. Herein, we present a method named percentage of overlapping functions (POF) and illustrate how it is used to perform the functional comparison of microarray data generated across multiple platforms. This method facilitates the determination of functional differences or similarities in microarray data generated from multiple array platforms across all the functions that are presented on these platforms. This method can also be used to compare the functional differences or similarities between experiments, projects, or laboratories. JF - Methods in molecular biology (Clifton, N.J.) AU - Li, Zhiguang AU - Kwekel, Joshua C AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. zhiguang.li@fda.hhs.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 123 EP - 139 VL - 802 KW - Index Medicus KW - Rats KW - Software KW - Animals KW - Programming Languages KW - Humans KW - Computational Biology -- methods KW - Databases, Genetic KW - Internet KW - Gene Expression Profiling -- methods KW - Oligonucleotide Array Sequence Analysis -- methods KW - Molecular Sequence Annotation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908010042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Functional+comparison+of+microarray+data+across+multiple+platforms+using+the+method+of+percentage+of+overlapping+functions.&rft.au=Li%2C+Zhiguang%3BKwekel%2C+Joshua+C%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Zhiguang&rft.date=2012-01-01&rft.volume=802&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-61779-400-1_9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-30 N1 - Date created - 2011-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-61779-400-1_9 ER - TY - JOUR T1 - Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin. AN - 902344318; 22047163 AB - Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure. JF - Journal of toxicology and environmental health. Part A AU - Franko, Jennifer AU - Meade, B J AU - Frasch, H Frederick AU - Barbero, Ana M AU - Anderson, Stacey E AD - Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2012 PY - 2012 DA - 2012 SP - 50 EP - 62 VL - 75 IS - 1 SN - 1528-7394, 1528-7394 KW - Caprylates KW - 0 KW - Cytokines KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Inflammation -- chemically induced KW - Mice KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Mice, Inbred BALB C KW - Male KW - Female KW - Administration, Topical KW - Inflammation -- pathology KW - Caprylates -- administration & dosage KW - Skin Absorption -- drug effects KW - Fluorocarbons -- administration & dosage KW - Caprylates -- metabolism KW - Fluorocarbons -- toxicity KW - Caprylates -- toxicity KW - Dermis -- pathology KW - Dermis -- drug effects KW - Dermis -- metabolism KW - Fluorocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902344318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Dermal+penetration+potential+of+perfluorooctanoic+acid+%28PFOA%29+in+human+and+mouse+skin.&rft.au=Franko%2C+Jennifer%3BMeade%2C+B+J%3BFrasch%2C+H+Frederick%3BBarbero%2C+Ana+M%3BAnderson%2C+Stacey+E&rft.aulast=Franko&rft.aufirst=Jennifer&rft.date=2012-01-01&rft.volume=75&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.615108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-21 N1 - Date created - 2011-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287394.2011.615108 ER - TY - JOUR T1 - Ethics and Scientific Integrity in Public Health, Epidemiological and Clinical Research AN - 1627731548 AB - The ethics and scientific integrity of biomedical and public health research requires that researchers behave in appropriate ways. However, this requires more than following of published research guidelines that seek to prevent scientific misconduct relating to serious deviations from widely accepted scientific norms for proposing, conducting, and reporting research (e.g., fabrication or falsification of research data or failures to report potential conflicts of interest). In this paper we argue for a broader account of scientific integrity, one consistent with that defended by the United States Institute of Medicine, involving a commitment to intellectual honesty and personal responsibility for oneʼs actions as a researcher and to practices consistent with the responsible conduct of research and protection of the research participants. Maintaining high standards of ethical and scientific integrity helps to maintain public trust in the research enterprise. An increasing number of authors have pointed to the importance of mentoring and education in relation to the responsible conduct of science in preventing transgressions of scientific integrity. Just like in clinical research and biomedicine, epidemiologists and other public health researchers have the responsibility to exhibit and foster the very highest standards of scientific integrity. JF - Public Health Reviews AU - Coughlin, Steven S AU - Barker, Amyre AU - Dawson, Angus AD - Research Service, Veterans Affairs Medical Center, Washington, DC, USA; Food and Drug Administration, Rockville, MD, USA ; Medicine, Ethics, Society and History, School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK Y1 - 2012 PY - 2012 DA - 2012 SP - 1 EP - 13 CY - Dordrecht PB - Springer Science & Business Media VL - 34 IS - 1 SN - 0301-0422 KW - Medical Sciences--Oncology KW - Ethics KW - clinical research KW - epidemiology KW - plagiarism KW - public health KW - scientific integrity KW - scientific misconduct KW - Biomedicine KW - Clinical research KW - Clinical standards KW - Fabrication KW - Falsification KW - Health KW - Honesty KW - Integrity KW - Medical research KW - Mentoring KW - Misconduct KW - Public health KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627731548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reviews&rft.atitle=Ethics+and+Scientific+Integrity+in+Public+Health%2C+Epidemiological+and+Clinical+Research&rft.au=Coughlin%2C+Steven+S%3BBarker%2C+Amyre%3BDawson%2C+Angus&rft.aulast=Coughlin&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=&rft.issue=571&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Institute of Medicine N1 - Date revised - 2014-11-10 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US ER - TY - JOUR T1 - The U.S. RDA Test Process AN - 1504415028; 201402493 AB - From July through December 2010, three U.S. national libraries, the Library of Congress, the National Agricultural Library, and the National Library of Medicine, coordinated a test of Resource Description and Access (RDA) that included 23 other test participants representing a broad range of institutions. The goal of the RDA test was to assure the operational, technical, and economic feasibility of the new cataloging code in order to help determine whether the national libraries would decide to implement the new code. The design and methodology of the test, how the data were analyzed, and specific impact of RDA on the serials community were presented. Adapted from the source document. JF - Serials Librarian AU - Boehr, Diane AU - Reynolds, Regina Romano AU - Shrader, Tina AD - National Library of Medicine, National Institute of Health, Department of Health and Human Services Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 125 EP - 139 PB - Taylor & Francis, Philadelphia PA VL - 62 IS - 1-4 SN - 0361-526X, 0361-526X KW - Resource Description and Access (RDA) KW - testing KW - methodology KW - data analysis KW - National libraries KW - Serials KW - Testing KW - Data analysis KW - Resource Description & Access-RDA KW - article KW - 12.13: CATALOGUING RULES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504415028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Serials+Librarian&rft.atitle=The+U.S.+RDA+Test+Process&rft.au=Boehr%2C+Diane%3BReynolds%2C+Regina+Romano%3BShrader%2C+Tina&rft.aulast=Boehr&rft.aufirst=Diane&rft.date=2012-01-01&rft.volume=62&rft.issue=1-4&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Serials+Librarian&rft.issn=0361526X&rft_id=info:doi/10.1080%2F0361526X.2012.652485 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2014-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - SELID4 N1 - SubjectsTermNotLitGenreText - National libraries; Testing; Resource Description & Access-RDA; Data analysis; Serials DO - http://dx.doi.org/10.1080/0361526X.2012.652485 ER - TY - JOUR T1 - The genetic toxicity of methylphenidate: a review of the current literature AN - 1443376618; 18643304 AB - Attention deficit/hyperactivity disorder (ADHD), a common children's behavioral disorder, is characterized by inattention, hyperactivity and impulsivity. The disorder is thought to stem from abnormalities in the catecholamine pathway and the symptoms of the disorder have been successfully treated with methylphenidate (MPH) since the FDA approved the drug in the 1950s. MPH underwent the appropriate safety testing as part of the FDA approval process; however, a publication in 2005 that reported significant increases in cytogenetic damage in the lymphocytes of MPH-treated pediatric patients caused concern for patients and their families, the pharmaceutical industry and regulatory agencies. This communication will review the many studies that were subsequently initiated worldwide to address the genetic safety of MPH in both animal models and human subjects. Animal experiments broadened the study protocols used in the 2005 investigation to include a wider dose-range, a longer treatment period and automated scoring of biological endpoints, where possible, to reduce observer bias. The human subject studies replicated the experimental design used in the 2005 study, but increased the treatment periods and the sizes of the study populations. Neither the laboratory animal nor human subject studies found an increase in any of the measures of genetic damage that were evaluated. Taken together, these new studies are consistent with the original safety evaluation of the FDA and do not support the hypothesis that MPH treatment increases the risk of genetic damage in ADHD patients. Published 2012. This article is a US Government work and is in the public domain in the USA. The symptoms of Attention Deficit/Hyperactivity Disorder (ADHD) are effectively treated with methylphenidate (MPH). In 2005, reported increases in cytogenetic damage in the lymphocytes of MPH-treated pediatric patients caused world-wide concern. Numerous studies were initiated to verify or refute the findings. As reviewed in this communication, neither the laboratory animal nor human subject studies found an increase in MPH-induced genetic damage. The subsequent studies do not support the initial hypothesis that MPH treatment increases the risk of genetic damage in ADHD patients. JF - Journal of Applied Toxicology AU - Morris, Suzanne M AU - Petibone, Dayton M AU - Lin, Wei-Jiun AU - Chen, James J AU - Vitiello, Benedetto AU - Witt, Kristine L AU - Mattison, Donald R AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA. PY - 2012 SP - 756 EP - 764 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 10 SN - 0260-437X, 0260-437X KW - Genetics Abstracts; Toxicology Abstracts KW - methylphenidate KW - ADHD KW - chromosome damage KW - mutation KW - Pediatrics KW - Attention deficit hyperactivity disorder KW - Animal models KW - Laboratory animals KW - Population studies KW - Methylphenidate KW - Toxicity KW - Lymphocytes KW - Children KW - Catecholamines KW - impulsive behavior KW - Pharmaceuticals KW - Drugs KW - Attention KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443376618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=The+genetic+toxicity+of+methylphenidate%3A+a+review+of+the+current+literature&rft.au=Morris%2C+Suzanne+M%3BPetibone%2C+Dayton+M%3BLin%2C+Wei-Jiun%3BChen%2C+James+J%3BVitiello%2C+Benedetto%3BWitt%2C+Kristine+L%3BMattison%2C+Donald+R&rft.aulast=Morris&rft.aufirst=Suzanne&rft.date=2012-01-01&rft.volume=32&rft.issue=10&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2721 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Pediatrics; Attention deficit hyperactivity disorder; Laboratory animals; Animal models; Methylphenidate; Population studies; Lymphocytes; Toxicity; Children; Catecholamines; impulsive behavior; Pharmaceuticals; Attention; Drugs DO - http://dx.doi.org/10.1002/jat.2721 ER - TY - JOUR T1 - Chemoinformatics and chemical genomics: potential utility of in silico methods AN - 1443376370; 18643307 AB - Computational life sciences and informatics are inseparably intertwined and they lie at the heart of modern biology, predictive quantitative modeling and high-performance computing. Two of the applied biological disciplines that are poised to benefit from such progress are pharmacology and toxicology. This review will describe in silico chemoinformatics methods such as (quantitative) structure-activity relationship modeling and will overview how chemoinformatic technologies are considered in applied regulatory research. Given the post-genomics era and large-scale repositories of omics data that are available, this review will also address potential applications of in silico techniques in chemical genomics. Chemical genomics utilizes small molecules to explore the complex biological phenomena that may not be not amenable to straightforward genetic approach. The reader will gain the understanding that chemoinformatics stands at the interface of chemistry and biology with enabling systems for mapping, statistical modeling, pattern recognition, imaging and database tools. The great potential of these technologies to help address complex issues in the toxicological sciences is appreciated with the applied goal of the protection of public health. Published 2012. This article is a US Government work and is in the public domain in the USA. Two of the applied biological disciplines that are poised to benefit from progress in computational life sciences and informatics are pharmacology and toxicology. This review will describe in silico chemoinformatics methods such as (quantitative) structure-activity relationship modeling and will overview how chemoinformatic technologies are considered in applied regulatory research. Given the post-genomics era and large-scale repositories of omics data that are available, this review will also address potential applications of in silico techniques in chemical genomics. JF - Journal of Applied Toxicology AU - Valerio, Luis G AU - Choudhuri, Supratim AD - Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA., luis.valerio@fda.hhs.gov PY - 2012 SP - 880 EP - 889 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 11 SN - 0260-437X, 0260-437X KW - Genetics Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - in silico toxicology KW - in silico methods KW - informatics KW - QSAR KW - computational toxicology KW - drug safety KW - safety assessment KW - genotoxicity KW - cardiac safety KW - chemoinformatics KW - chemical genomics KW - chemical epigenomics KW - Mathematical models KW - Data processing KW - Pharmacology KW - Informatics KW - Computer applications KW - imaging KW - Public health KW - Databases KW - Pattern recognition KW - USA KW - Reviews KW - Mapping KW - genomics KW - Structure-activity relationships KW - Toxicology KW - Technology KW - Gene mapping KW - G 07880:Human Genetics KW - H 12000:Epidemiology and Public Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443376370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Chemoinformatics+and+chemical+genomics%3A+potential+utility+of+in+silico+methods&rft.au=Valerio%2C+Luis+G%3BChoudhuri%2C+Supratim&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2012-01-01&rft.volume=32&rft.issue=11&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2804 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Data processing; Mathematical models; Informatics; Pharmacology; Computer applications; imaging; Public health; Pattern recognition; Databases; Reviews; genomics; Structure-activity relationships; Gene mapping; Mapping; Toxicology; Technology; USA DO - http://dx.doi.org/10.1002/jat.2804 ER - TY - JOUR T1 - Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay AN - 1443373766; 18643308 AB - Titanium dioxide nanoparticles (TiO sub(2)-NPs) are being used increasingly for various industrial and consumer products, including cosmetics and sunscreens because of their photoactive properties. Therefore, the toxicity of TiO sub(2)-NPs needs to be thoroughly understood. In the present study, the genotoxicity of 10nm uncoated sphere TiO sub(2)-NPs with an anatase crystalline structure, which has been well characterized in a previous study, was assessed using the Salmonella reverse mutation assay (Ames test) and the single-cell gel electrophoresis (Comet) assay. For the Ames test, Salmonella strains TA102, TA100, TA1537, TA98 and TA1535 were preincubated with eight different concentrations of the TiO sub(2)-NPs for 4h at 37 degree C, ranging from 0 to 4915.2 mu g per plate. No mutation induction was found. Analyses with transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS) showed that the TiO sub(2)-NPs were not able to enter the bacterial cell. For the Comet assay, TK6 cells were treated with 0-200 mu g ml super(-1) TiO sub(2)-NPs for 24h at 37 degree C to detect DNA damage. Although the TK6 cells did take up TiO sub(2)-NPs, no significant induction of DNA breakage or oxidative DNA damage was observed in the treated cells using the standard alkaline Comet assay and the endonuclease III (EndoIII) and human 8-hydroxyguanine DNA-glycosylase (hOGG1)-modified Comet assay, respectively. These results suggest that TiO sub(2)-NPs are not genotoxic under the conditions of the Ames test and Comet assay. Published 2012. This article is a US Government work and is in the public domain in the USA. The genotoxicity of 10 nm anatase titanium dioxide nanoparticles was assessed using the Ames test and Comet assay. The nanoparticles were neither mutagenic in the Ames test nor genotoxic in the Comet assay. The results also suggest that the Ames test may not be suitable to measure the mutagenicity of the nanoparticles because the bacterial cells cannot take up the nanoparticles. JF - Journal of Applied Toxicology AU - Woodruff, Robert S AU - Li, Yan AU - Yan, Jian AU - Bishop, Michelle AU - Jones, MYvonne AU - Watanabe, Fumiya AU - Biris, Alexandru S AU - Rice, Penelope AU - Zhou, Tong AU - Chen, Tao AD - Division of Microbiology, Arkansas Regional Laboratory, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. PY - 2012 SP - 934 EP - 943 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 11 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - titanium dioxide nanoparticles KW - Ames test KW - Comet assay KW - mutations KW - genotoxicity KW - AMES test KW - Transmission electron microscopy KW - Cosmetics KW - Spectroscopy KW - Titanium dioxide KW - Sunscreens KW - Consumers KW - Endonuclease KW - Mutagenicity KW - Genotoxicity KW - Toxicity KW - Gel electrophoresis KW - DNA damage KW - USA KW - 8-Hydroxyguanine KW - Ionizing radiation KW - Microscopy KW - DNA KW - X-ray spectroscopy KW - Salmonella KW - Mutation KW - nanoparticles KW - X 24340:Cosmetics, Toiletries & Household Products KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443373766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Genotoxicity+evaluation+of+titanium+dioxide+nanoparticles+using+the+Ames+test+and+Comet+assay&rft.au=Woodruff%2C+Robert+S%3BLi%2C+Yan%3BYan%2C+Jian%3BBishop%2C+Michelle%3BJones%2C+MYvonne%3BWatanabe%2C+Fumiya%3BBiris%2C+Alexandru+S%3BRice%2C+Penelope%3BZhou%2C+Tong%3BChen%2C+Tao&rft.aulast=Woodruff&rft.aufirst=Robert&rft.date=2012-01-01&rft.volume=32&rft.issue=11&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2781 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Transmission electron microscopy; Genotoxicity; Cosmetics; Spectroscopy; Ames test; Gel electrophoresis; DNA damage; Titanium dioxide; 8-Hydroxyguanine; Ionizing radiation; Sunscreens; Consumers; Comet assay; Endonuclease; nanoparticles; Mutation; AMES test; Microscopy; X-ray spectroscopy; DNA; Toxicity; Salmonella; USA DO - http://dx.doi.org/10.1002/jat.2781 ER - TY - JOUR T1 - Compliance With Bloodborne Pathogen Standards at Eight Correctional Facilities AN - 1434034750; 18507524 AB - This study had three objectives: (a) to examine compliance with the Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens (BBPs) Standard at eight correctional facilities, (b) to identify potential barriers to compliance, and (c) to discuss steps to address these barriers. Eight facilities of different sizes and locations were visited to examine employer adherence to 15 selected BBP risk reduction activities. Facility compliance was less than 50% for four activities: updating exposure control plans, implementing use of appropriate safer medical devices, soliciting employee input on selection of safer devices, and training medical staff when such devices are implemented. Inconsistent compliance may be due to difficulties in applying the standards in the correctional health care work setting. Any BBP training and health communication activities targeted to correctional health care workers should be tailored to the correctional facility setting. JF - Journal of Correctional Health Care AU - Lehman, Everett J AU - Huy, Janice M AU - Viet, Susan M AU - Gomaa, Ahmed AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA  , ELehman@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 29 EP - 44 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 18 IS - 1 SN - 1078-3458, 1078-3458 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Prisons KW - Communications KW - Safety regulations KW - Health care KW - Training KW - Compliance KW - Pathogens KW - Risk reduction KW - Medical personnel KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434034750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Correctional+Health+Care&rft.atitle=Compliance+With+Bloodborne+Pathogen+Standards+at+Eight+Correctional+Facilities&rft.au=Lehman%2C+Everett+J%3BHuy%2C+Janice+M%3BViet%2C+Susan+M%3BGomaa%2C+Ahmed&rft.aulast=Lehman&rft.aufirst=Everett&rft.date=2012-01-01&rft.volume=18&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Correctional+Health+Care&rft.issn=10783458&rft_id=info:doi/10.1177%2F1078345811421466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Number of references - 28 N1 - Last updated - 2013-10-21 N1 - SubjectsTermNotLitGenreText - Prisons; Safety regulations; Communications; Health care; Training; Compliance; Risk reduction; Pathogens; Medical personnel DO - http://dx.doi.org/10.1177/1078345811421466 ER - TY - JOUR T1 - The utility of the integrated design of the Medical Expenditure Panel Survey to inform mortality related studies AN - 1373426819; 201330952 AB - The analytic capacity of surveys can be dramatically enhanced through the linkage to existing secondary data sources at higher levels of aggregation as well as through direct matches to additional health and socio-economic measures acquired for the same set of sample units from other sources of survey specific or administrative data. In this paper, the capacity of the Medical Expenditure Panel Survey (MEPS) to enhance longitudinal analyses focused on mortality studies is discussed. The first set of analyses examines the differentials in pie-dispositional factors that distinguish a representative group of decedents from their surviving counterparts. This is followed by a more extensive model-based study to assess the relationship between antecedent health and health care related factors and mortality. The relationship between medical expenditure levels over time and mortality is also examined to illustrate the enhanced set of longitudinal analyses that are possible through this framework. These longitudinal analyses are based on linkages of the MEPS to the National Health Interview Survey and the National Death Index. Adapted from the source document. JF - Journal of Economic and Social Measurement AU - Cohen, Steven B AD - Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road John M. Eisenberg Building, Rockville, MD 20850, USA scohen@ahrq.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 337 EP - 354 PB - IOS Press, Amsterdam The Netherlands VL - 37 IS - 4 SN - 0747-9662, 0747-9662 KW - Survey integration, MEPS, NHIS, NDI KW - Death KW - Mortality Rates KW - Surveys KW - Health KW - Medicine KW - Health Care Services KW - article KW - 2460: policy, planning, forecasting; social indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373426819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+and+Social+Measurement&rft.atitle=The+utility+of+the+integrated+design+of+the+Medical+Expenditure+Panel+Survey+to+inform+mortality+related+studies&rft.au=Cohen%2C+Steven+B&rft.aulast=Cohen&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.title=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JEMEEZ N1 - SubjectsTermNotLitGenreText - Mortality Rates; Medicine; Health Care Services; Health; Surveys; Death DO - http://dx.doi.org/10.3233/JEM-120363 ER - TY - JOUR T1 - Transforming Community Health and Primary Care Education Using Clinical and Administrative Data and Geographic Information Systems AN - 1373423130; 201306497 AB - Community-oriented primary care (COPC), a common model used for integrating the principles of primary care and public health, has been taught in family medicine residency programs to create community-responsive providers. As the initial step in a comprehensive COPC curriculum for a family medicine residency program, we used GIS maps, graphs, and tables to introduce new interns to the community served by the residency clinic. A fourteen-question pre/post test showed that interns' knowledge and understanding of the community improvement overall were deficient. Using practice-based administrative data combined with population-based data can efficiently and effectively improve interns' knowledge of the communities they serve. Adapted from the source document. JF - Journal of Map & Geography Libraries AU - Hayashi, Arthur Seiji AU - Bazemore, Andrew AU - McIntyre, Jessica AD - Health Resources and Services Administration, Bureau of Primary Health Care, Washington, DC, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 61 EP - 70 PB - Haworth/Taylor & Francis, Philadelphia PA VL - 7 IS - 1 SN - 1542-0353, 1542-0353 KW - Community medicine, community oriented primary care, geographic information systems (GIS), residency education KW - Education KW - Communities KW - Health care KW - Medicine KW - Geographic information systems KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373423130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Map+%26+Geography+Libraries&rft.atitle=Transforming+Community+Health+and+Primary+Care+Education+Using+Clinical+and+Administrative+Data+and+Geographic+Information+Systems&rft.au=Hayashi%2C+Arthur+Seiji%3BBazemore%2C+Andrew%3BMcIntyre%2C+Jessica&rft.aulast=Hayashi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Communities; Geographic information systems; Health care; Medicine; Education ER - TY - JOUR T1 - Accumulating Evidence for a Drug-Drug Interaction Between Methotrexate and Proton Pump Inhibitors AN - 1367482692; 16643426 AB - BACKGROUND: A number of medications are known to interact with methotrexate through various mechanisms. The aim of this article is to apprise practitioners of a new labeling change based on the accumulating evidence for a possible drug-drug interaction between methotrexate (primarily at high doses) and proton pump inhibitors (PPIs). METHODS: The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database of spontaneous adverse event reports and the published literature were searched for cases reporting an interaction between methotrexate and PPIs. RESULTS: A search of the AERS database and existing literature found several individual case reports of drug-drug interactions and three additional supportive studies that suggest potential underlying mechanisms for the interaction. CONCLUSION: There is evidence to suggest that concomitant use of methotrexate (primarily at high doses) with PPIs such as omeprazole, esomeprazole, and pantoprazole may decrease methotrexate clearance, leading to elevated serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. In several case reports, no methotrexate toxicity was found when a histamine H2 blocker was substituted for a PPI. Based on the reviewed data, the FDA updated the methotrexate label to include the possible drug-drug interaction between high-dose methotrexate and PPIs. Physicians should be alerted to this potential drug-drug interaction in patients receiving concomitant high-dose methotrexate and PPIs. JF - Oncologist AU - Bezabeh, Shewit AU - Mackey, Ann Corken AU - Kluetz, Paul AU - Jappar, Dilara AU - Korvick, Joyce AD - Office of Surveillance and Epidemiology and Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 550 EP - 554 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 United States VL - 17 IS - 4 SN - 1083-7159, 1083-7159 KW - Toxicology Abstracts KW - Serum levels KW - Databases KW - Data processing KW - Case reports KW - Protons KW - Methotrexate KW - Omeprazole KW - Metabolites KW - Toxicity KW - Histamine KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367482692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=Accumulating+Evidence+for+a+Drug-Drug+Interaction+Between+Methotrexate+and+Proton+Pump+Inhibitors&rft.au=Bezabeh%2C+Shewit%3BMackey%2C+Ann+Corken%3BKluetz%2C+Paul%3BJappar%2C+Dilara%3BKorvick%2C+Joyce&rft.aulast=Bezabeh&rft.aufirst=Shewit&rft.date=2012-01-01&rft.volume=17&rft.issue=4&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Serum levels; Databases; Data processing; Case reports; Protons; Omeprazole; Methotrexate; Metabolites; Toxicity; Histamine ER - TY - JOUR T1 - Evaluation of a Bladder Cancer Cluster in a Population of Criminal Investigators with the Bureau of Alcohol, Tobacco, Firearms and Explosives-Part 1: The Cancer Incidence AN - 1356933672; 18053492 AB - This study investigated a bladder cancer cluster in a cohort of employees, predominately criminal investigators, participating in a medical surveillance program with the United States Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) between 1995 and 2007. Standardized incidence ratios (SIRs) were used to compare cancer incidences in the ATF population and the US reference population. Seven cases of bladder cancer (five cases verified by pathology report at time of analysis) were identified among a total employee population of 3,768 individuals. All cases were white males and criminal investigators. Six of seven cases were in the 30 to 49 age range at the time of diagnosis. The SIRs for white male criminal investigators undergoing examinations were 7.63 (95% confidence interval = 3.70-15.75) for reported cases and 5.45 (2.33-12.76) for verified cases. White male criminal investigators in the ATF population are at statistically significant increased risk for bladder cancer. JF - Journal of Environmental and Public Health AU - Davis, Susan R AU - Tao, Xuguang AU - Bernacki, Edward J AU - Alfriend, Amy S AD - Federal Occupational Health, Department of Health and Human Services, 4550 Montgomery Avenue, Suite 950, Bethesda, MD 20814, USA, sdavis228@comcast.net Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-9805, 1687-9805 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Alcohol KW - USA KW - Age KW - Firearms KW - Pathology KW - Urinary bladder KW - Tobacco KW - Standards KW - Explosives KW - Cancer KW - H 7000:Fire Safety KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356933672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Epigenetic+and+Mirna+Dysregulation+in+Liver+Nongenotoxic+and+Genotoxic+Tumorigenesis&rft.au=Kutanzi%2C+K%3BMelnyk%2C+S%3BKoturbash%2C+I%3BPogribny%2C+I&rft.aulast=Kutanzi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 1 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; Pathology; Firearms; Urinary bladder; Tobacco; Standards; Explosives; Cancer; USA DO - http://dx.doi.org/10.1155/2012/101850 ER - TY - JOUR T1 - Levels of Dichlorodiphenyltrichloroethane and its Metabolites in the Blood of Agrochemicals Retailers AN - 1356925514; 17933829 AB - Problem statement: In tropical countries like Nigeria, the storage, sales and handling of pesticide by agrochemical retailers in indoor stores located in open markets and residential areas were fraught with problem of undesirable side effect. Serum levels of 1, 1, 1-trichloro-2, 2-di (4-chlorophenyl) ethane (DDT) and its metabolite were measured among agrochemicals retailers in Taraba, Nigeria. Approach: Blood samples from 50 retailers were taken and analyzed by gas chromatography with an electron capture detector. The retailers were group into five exposure duration based on their years of involvement in trade viz; 1-5 years, 6-10 years, 11-15 years, 16-20 years, greater than or equal to 21 years. Results: Test detected 34 (50) retailers had residues of DDE, DDD, DDT and Aldrin in their blood. 68% of the retailers had DDE at mean concentration of 0.047 mg L-1, ranged from n.d-0.0721 mg L-1. 62% DDD (mean = 0.0101 mg L-1, range = n.d-0.034 mg L-1), 58% DDT (mean = 0.0120 mg L-1, ranged = n.d-0.1120 mg L-1) and 52% Aldrin (mean = 0.0045 mg L-1, ranged = 0.0100-0.0265 mg L-1), The total content DDT(sum of DDE, DDD and DDT ) in the whole blood samples was 0.062 mg L-1 and ranged from 0.0008-0.185 mg L-1. Dieldrin was not detected in any of the samples analyzed. Conclusion: Despite the banned, the observed trend for all the DDTs and metabolites shows that retailers are occupationally exposed due to the sales and handling of agrochemicals in retailers' stores. The need for stiffmonitoring and enforcement by regulatory bodies is of paramount important. JF - American Journal of Environmental Sciences AU - Hotton, Anthony J AU - Barminas, Jeoffrey T AU - Osemeahon, Sunday A AD - National Agency for Food and Drug Administration and Control, P.M.B 1018 Jalingo, Taraba State, Nigeria Y1 - 2012 PY - 2012 DA - 2012 SP - 170 PB - Science Publications, Vails Gate Heights Dr Vails Gate NY 12584 United States VL - 8 IS - 2 SN - 1553-345X, 1553-345X KW - Health & Safety Science Abstracts KW - Nigeria KW - Insecticides KW - Nitrous oxide KW - Residues KW - Ethane KW - DDT KW - Aldrin KW - DDE KW - Metabolites KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Environmental+Sciences&rft.atitle=Levels+of+Dichlorodiphenyltrichloroethane+and+its+Metabolites+in+the+Blood+of+Agrochemicals+Retailers&rft.au=Hotton%2C+Anthony+J%3BBarminas%2C+Jeoffrey+T%3BOsemeahon%2C+Sunday+A&rft.aulast=Thompson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 16 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Insecticides; Residues; Nitrous oxide; Ethane; DDE; Aldrin; DDT; Metabolites; Occupational exposure; Nigeria ER - TY - JOUR T1 - Factors affecting the performance, energy consumption, and carbon footprint for ultra low temperature freezers: case study at the National Institutes of Health AN - 1318696194; 17760702 AB - The National Institutes of Health (NIH) recognises an opportunity to significantly reduce the energy consumption and its carbon footprint from plug load equipment can be realised by managing -86 degree C ultra low temperature (ULT) freezers. Energy meters were installed on ULT freezers operating in actual laboratory conditions to determine how their energy consumption is influenced by various factors. Ambient temperature, freezer condition, age, capacity, and set point temperature were the factors that were examined. Based on the study, ultra low temperature freezers operated efficiently when they are: well maintained, operating in ambient temperatures less than 25 degree C, less than ten years old, are operating at a set point higher than -80 degree C, and have an internal capacity greater than 23 ft super(3). The results of the case study are presented and discussed. Freezer performance was assessed to determine how ambient temperature and the freezer condition influenced the freezer's ability to reach set point temperature. The results of the study indicate a freezer that is not maintained and operating in ambient temperatures above 32 degree C produce cabinet temperatures 12.5 degree C warmer than the desired set point temperature. JF - World Review of Science, Technology and Sustainable Development AU - Gumapas, Leo Angelo M AU - Simons, Glenn AD - US Public Health Service Commissioned Corps, Office of Research Facilities, Division of Environmental Protection, National Institutes of Health, Room 2W64, 9000 Rockville Pike Building 13, Bethesda, MD 20892, USA. Y1 - 2012 PY - 2012 DA - 2012 SP - 129 EP - 141 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB United Kingdom VL - 10 IS - 1-2-3 SN - 1741-2242, 1741-2242 KW - Health & Safety Science Abstracts; Environment Abstracts; Sustainability Science Abstracts KW - ENERGY AND ENVIRONMENT KW - MANAGEMENT AND BUSINESS KW - Environment and Sustainable Development KW - Operational Management and Marketing KW - Policy and Organisational Management KW - Age KW - Low temperature KW - Case studies KW - Reviews KW - Temperature KW - Sustainable development KW - Energy consumption KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1318696194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+Review+of+Science%2C+Technology+and+Sustainable+Development&rft.atitle=Factors+affecting+the+performance%2C+energy+consumption%2C+and+carbon+footprint+for+ultra+low+temperature+freezers%3A+case+study+at+the+National+Institutes+of+Health&rft.au=Mellon%2C+D&rft.aulast=Mellon&rft.aufirst=D&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Case studies; Low temperature; Reviews; Temperature; Sustainable development; Energy consumption DO - http://dx.doi.org/10.1504/WRSTSD.2013.050786 ER - TY - JOUR T1 - The upper midwest health study: a case-control study of pesticide applicators and risk of glioma AN - 1315614787; 17720860 AB - Background: An excess incidence of brain cancer in farmers has been noted in several studies. The National Institute for Occupational Safety and Health developed the Upper Midwest Health Study (UMHS) as a case-control study of intracranial gliomas and pesticide uses among rural residents. Previous studies of UMHS participants, using "ever-never" exposure to farm pesticides and analyzing men and women separately, found no positive association of farm pesticide exposure and glioma risks. The primary objective was to determine if quantitatively estimated exposure of pesticide applicators was associated with an increased risk of glioma in male and female participants. Methods: The study included 798 histologically confirmed primary intracranial glioma cases (45 % with proxy respondents) and 1,175 population-based controls, all adult (age 18-80) non-metropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. The analyses used quantitatively estimated exposure from questionnaire responses evaluated by an experienced industrial hygienist with 25 years of work on farm pesticide analyses. Odds ratios (ORs) and 95 % confidence intervals (CIs) using unconditional logistic regression modeling were calculated adjusting for frequency-matching variables (10-year age group and sex), and for age and education (a surrogate for socioeconomic status). Analyses were separately conducted with or without proxy respondents. Results: No significant positive associations with glioma were observed with cumulative years or estimated lifetime cumulative exposure of farm pesticide use. There was, a significant inverse association for phenoxy pesticide used on the farm (OR 0.96 per 10 g-years of cumulative exposure, CI 0.93-0.99). No significant findings were observed when proxy respondents were excluded. Non-farm occupational applicators of any pesticide had decreased glioma risk: OR 0.72, CI 0.52-0.99. Similarly, house and garden pesticide applicators had a decreased risk of glioma: OR 0.79, CI 0.66-0.93, with statistically significant inverse associations for use of 2,4-D, arsenates, organophosphates, and phenoxys. Conclusions: These results are consistent with our previous findings for UMHS of reported farm pesticide exposure and support a lack of positive association between pesticides and glioma. JF - Environmental Health (London) AU - Yiin, James H AU - Ruder, Avima M AU - Stewart, Patricia A AU - Waters, Martha A AU - Carreon, Tania AU - Butler, Mary Ann AU - Calvert, Geoffrey M AU - Davis-King, Karen E AU - Schulte, Paul A AU - Mandel, Jack S AU - Morton, Roscoe F AU - Reding, Douglas J AU - Rosenman, Kenneth D AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 39 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1476-069X, 1476-069X KW - Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - 2,4-Dichlorophenoxyacetic acid KW - USA, Iowa KW - Pesticides KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315614787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+%28London%29&rft.atitle=The+upper+midwest+health+study%3A+a+case-control+study+of+pesticide+applicators+and+risk+of+glioma&rft.au=Yiin%2C+James+H%3BRuder%2C+Avima+M%3BStewart%2C+Patricia+A%3BWaters%2C+Martha+A%3BCarreon%2C+Tania%3BButler%2C+Mary+Ann%3BCalvert%2C+Geoffrey+M%3BDavis-King%2C+Karen+E%3BSchulte%2C+Paul+A%3BMandel%2C+Jack+S%3BMorton%2C+Roscoe+F%3BReding%2C+Douglas+J%3BRosenman%2C+Kenneth+D&rft.aulast=Yiin&rft.aufirst=James&rft.date=2012-01-01&rft.volume=11&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+%28London%29&rft.issn=1476069X&rft_id=info:doi/10.1186%2F1476-069X-11-39 L2 - http://www.ehjournal.net/content/11/1/39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Pesticides; USA, Iowa DO - http://dx.doi.org/10.1186/1476-069X-11-39 ER - TY - JOUR T1 - Clinical and Epidemiologic Features of Diarrheal Disease due to Aeromonas hydrophila and Plesiomonas shigelloides Infections Compared with Those due to Vibrio cholerae Non-O1 and Vibrio parahaemolyticus in Bangladesh AN - 1315610184; 17590842 AB - Using data from the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) from 1996 to 2001, we compared the clinical features of diarrhea in patients with stool specimens yielding only A. hydrophila (189 patients; 1.4% of 13,970 patients screened) or P. shigelloides (253 patients) compared to patients with sole V. cholerae non-O1 infection (99 patients) or V. parahaemolyticus infection (126 patients). Patients exhibited similar frequencies of fever (temperature >37.8 degree C), stools characterized as watery, and stools containing visible mucus. Dehydration was observed more often among patients with V. parahaemolyticus or V. cholerae non-O1 infection. Compared to patients infected with V. parahaemolyticus , those with A. hydrophila , P. shigelloides , or V. cholerae non-O1 infection were less likely to report visible blood in the stool and, on microscopic examination, less likely to exhibit stool red blood cell and white blood cell counts exceeding 20 cells per high power field. The proportion of patients reporting subjective cure at the time of discharge was significantly smaller for those infected with V. parahaemolyticus. These findings suggest that A. hydrophila and P. shigelloides produce diarrheal disease that is less severe than that resulting from infection with V. cholerae non-O1 or V. parahaemolyticus. JF - ISRN Microbiology AU - Klontz, Erik H AU - Faruque, Abu SG AU - Das, Sumon K AU - Malek, Mohammed A AU - Islam, Zhahirul AU - Luby, Stephen P AU - Klontz, Karl C AD - Carleton College, One North College Street, Northfield, MN 55057, USA, karl.klontz@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Diarrhea KW - Data processing KW - Pathogenic bacteria KW - Leukocytes KW - Erythrocytes KW - Aeromonas hydrophila KW - Mucus KW - Infection KW - Public health KW - Fever KW - Vibrio cholerae KW - Plesiomonas shigelloides KW - Vibrio parahaemolyticus KW - Microbiology KW - Blood cells KW - Feces KW - Bangladesh KW - Dehydration KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315610184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISRN+Microbiology&rft.atitle=Clinical+and+Epidemiologic+Features+of+Diarrheal+Disease+due+to+Aeromonas+hydrophila+and+Plesiomonas+shigelloides+Infections+Compared+with+Those+due+to+Vibrio+cholerae+Non-O1+and+Vibrio+parahaemolyticus+in+Bangladesh&rft.au=Klontz%2C+Erik+H%3BFaruque%2C+Abu+SG%3BDas%2C+Sumon+K%3BMalek%2C+Mohammed+A%3BIslam%2C+Zhahirul%3BLuby%2C+Stephen+P%3BKlontz%2C+Karl+C&rft.aulast=Klontz&rft.aufirst=Erik&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ISRN+Microbiology&rft.issn=2090-7486&rft_id=info:doi/10.5402%2F2012%2F654819 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Number of references - 4 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Erythrocytes; Microbiology; Mucus; Blood cells; Public health; Dehydration; Temperature effects; Fever; Data processing; Diarrhea; Leukocytes; Feces; Infection; Vibrio cholerae; Plesiomonas shigelloides; Vibrio parahaemolyticus; Aeromonas hydrophila; Bangladesh DO - http://dx.doi.org/10.5402/2012/654819 ER - TY - JOUR T1 - Evidence for validity of five secondary data sources for enumerating retail food outlets in seven American Indian Communities in North Carolina AN - 1285094858; 17611515 AB - Background: Most studies on the local food environment have used secondary sources to describe the food environment, such as government food registries or commercial listings (e.g., Reference USA). Most of the studies exploring evidence for validity of secondary retail food data have used on-site verification and have not conducted analysis by data source (e.g., sensitivity of Reference USA) or by food outlet type (e.g., sensitivity of Reference USA for convenience stores). Few studies have explored the food environment in American Indian communities. To advance the science on measuring the food environment, we conducted direct, on-site observations of a wide range of food outlets in multiple American Indian communities, without a list guiding the field observations, and then compared our findings to several types of secondary data. Methods: Food outlets located within seven State Designated Tribal Statistical Areas in North Carolina (NC) were gathered from online Yellow Pages, Reference USA, Dun & Bradstreet, local health departments, and the NC Department of Agriculture and Consumer Services. All TIGER/Line 2009 roads (>1,500 miles) were driven in six of the more rural tribal areas and, for the largest tribe, all roads in two of its cities were driven. Sensitivity, positive predictive value, concordance, and kappa statistics were calculated to compare secondary data sources to primary data. Results: 699 food outlets were identified during primary data collection. Match rate for primary data and secondary data differed by type of food outlet observed, with the highest match rates found for grocery stores (97%), general merchandise stores (96%), and restaurants (91%). Reference USA exhibited almost perfect sensitivity (0.89). Local health department data had substantial sensitivity (0.66) and was almost perfect when focusing only on restaurants (0.91). Positive predictive value was substantial for Reference USA (0.67) and moderate for local health department data (0.49). Evidence for validity was comparatively lower for Dun & Bradstreet, online Yellow Pages, and the NC Department of Agriculture. Conclusions: Secondary data sources both over- and under-represented the food environment; they were particularly problematic for identifying convenience stores and specialty markets. More attention is needed to improve the validity of existing data sources, especially for rural local food environments. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Fleischhacker, Sheila E AU - Rodriguez, Daniel A AU - Evenson, Kelly R AU - Henley, Amanda AU - Gizlice, Ziya AU - Soto, Dolly AU - Ramachandran, Gowri AD - Senior Public Health & Science Policy Advisor, NIH Division of Nutrition Research Coordination, National Institutes of Health, US Department of Health and Human Services, Two Democracy Plaza, Room 635, 6707 Democracy Boulevard, MSC 5461, Bethesda, MD, 20892-5461, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 137 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1479-5868, 1479-5868 KW - Physical Education Index KW - Analysis KW - Diet KW - Exercise KW - Health KW - Indians KW - Observation KW - Restaurants KW - Statistics KW - Validity KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285094858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=Evidence+for+validity+of+five+secondary+data+sources+for+enumerating+retail+food+outlets+in+seven+American+Indian+Communities+in+North+Carolina&rft.au=Fleischhacker%2C+Sheila+E%3BRodriguez%2C+Daniel+A%3BEvenson%2C+Kelly+R%3BHenley%2C+Amanda%3BGizlice%2C+Ziya%3BSoto%2C+Dolly%3BRamachandran%2C+Gowri&rft.aulast=Fleischhacker&rft.aufirst=Sheila&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-9-137 L2 - http://www.ijbnpa.org/content/9/1/137 LA - English DB - Physical Education Index N1 - Date revised - 2013-02-01 N1 - Number of references - 47 N1 - Last updated - 2013-03-11 N1 - SubjectsTermNotLitGenreText - Indians; Statistics; Restaurants; Analysis; Validity; Observation; Health; Exercise; Diet DO - http://dx.doi.org/10.1186/1479-5868-9-137 ER - TY - JOUR T1 - Type I interferon and pattern recognition receptor signaling following particulate matter inhalation AN - 1272752317; 17574364 AB - Background: Welding, a process that generates an aerosol containing gases and metal-rich particulates, induces adverse physiological effects including inflammation, immunosuppression and cardiovascular dysfunction. This study utilized microarray technology and subsequent pathway analysis as an exploratory search for markers/mechanisms of in vivo systemic effects following inhalation. Mice were exposed by inhalation to gas metal arc - stainless steel (GMA-SS) welding fume at 40 mg/m super(3) for 3 hr/d for 10 d and sacrificed 4 hr, 14 d and 28 d post-exposure. Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling. Results: The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28 d. Remarkably, these effects showed consistency across all tissues indicating a systemic type I interferon response that was complemented by changes in serum proteins (decreased MMP-9, CRP and increased VCAM1, oncostatin M, IP-10). In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. Also, a canonical pathway indicated a coordinated response of multiple PRR and associated signaling molecules (Tlr7, Tlr2, Clec7a, Nlrp3, Myd88) to inhalation of GMA-SS. Conclusion: This methodological approach has the potential to identify consistent, prominent and/or novel pathways and provides insight into mechanisms that contribute to pulmonary and systemic effects following toxicant exposure. JF - Particle and Fibre Toxicology AU - Erdely, Aaron AU - Antonini, James M AU - Salmen-Muniz, Rebecca AU - Liston, Angie AU - Hulderman, Tracy AU - Simeonova, Petia P AU - Kashon, Michael L AU - Li, Shengqiao AU - Gu, Ja K AU - Stone, Samuel AU - Chen, Bean T AU - Frazer, David G AU - Zeidler-Erdely, Patti C AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 25 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Microarray KW - Welding KW - Interferon regulatory factor 7 KW - Cardiovascular disease KW - Chromium KW - Biomarker KW - Pattern recognition receptor KW - Whole blood cell gene expression KW - Aorta KW - Inhalation KW - beta -Interferon KW - Aerosols KW - TLR2 protein KW - DNA microarrays KW - Inflammation KW - Gene expression KW - oncostatin M KW - Pattern recognition KW - Lung KW - Transcription factors KW - alpha -Interferon KW - Gelatinase B KW - TLR7 protein KW - Toll-like receptors KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272752317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Type+I+interferon+and+pattern+recognition+receptor+signaling+following+particulate+matter+inhalation&rft.au=Erdely%2C+Aaron%3BAntonini%2C+James+M%3BSalmen-Muniz%2C+Rebecca%3BListon%2C+Angie%3BHulderman%2C+Tracy%3BSimeonova%2C+Petia+P%3BKashon%2C+Michael+L%3BLi%2C+Shengqiao%3BGu%2C+Ja+K%3BStone%2C+Samuel%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BZeidler-Erdely%2C+Patti+C&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-9-25 L2 - http://www.particleandfibretoxicology.com/content/9/1/25 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Number of references - 51 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Inhalation; Aerosols; Interferon regulatory factor 7; Aorta; TLR2 protein; DNA microarrays; Inflammation; Gene expression; Pattern recognition; oncostatin M; Lung; Transcription factors; alpha -Interferon; Welding; TLR7 protein; Gelatinase B; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1186/1743-8977-9-25 ER - TY - JOUR T1 - Effects of multiple conformers per compound upon 3-D similarity search and bioassay data analysis AN - 1272737969; 17574570 AB - Background: To improve the utility of PubChem, a public repository containing biological activities of small molecules, the PubChem3D project adds computationally-derived three-dimensional (3-D) descriptions to the small-molecule records contained in the PubChem Compound database and provides various search and analysis tools that exploit 3-D molecular similarity. Therefore, the efficient use of PubChem3D resources requires an understanding of the statistical and biological meaning of computed 3-D molecular similarity scores between molecules. Results: The present study investigated effects of employing multiple conformers per compound upon the 3-D similarity scores between ten thousand randomly selected biologically-tested compounds (10-K set) and between non-inactive compounds in a given biological assay (156-K set). When the "best-conformer-pair" approach, in which a 3-D similarity score between two compounds is represented by the greatest similarity score among all possible conformer pairs arising from a compound pair, was employed with ten diverse conformers per compound, the average 3-D similarity scores for the 10-K set increased by 0.11, 0.09, 0.15, 0.16, 0.07, and 0.18 for ST super( ST-opt ), CT super( ST-opt ), ComboT super( ST-opt ), ST super( CT-opt ), CT super( CT-opt ), and ComboT super( CT-opt ), respectively, relative to the corresponding averages computed using a single conformer per compound. Interestingly, the best-conformer-pair approach also increased the average 3-D similarity scores for the non-inactive-non-inactive (NN) pairs for a given assay, by comparable amounts to those for the random compound pairs, although some assays showed a pronounced increase in the per-assay NN-pair 3-D similarity scores, compared to the average increase for the random compound pairs. Conclusion: These results suggest that the use of ten diverse conformers per compound in PubChem bioassay data analysis using 3-D molecular similarity is not expected to increase the separation of non-inactive from random and inactive spaces "on average", although some assays show a noticeable separation between the non-inactive and random spaces when multiple conformers are used for each compound. The present study is a critical next step to understand effects of conformational diversity of the molecules upon the 3-D molecular similarity and its application to biological activity data analysis in PubChem. The results of this study may be helpful to build search and analysis tools that exploit 3-D molecular similarity between compounds archived in PubChem and other molecular libraries in a more efficient way. JF - Journal of Cheminformatics AU - Kim, Sunghwan AU - Bolton, Evan E AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, 20894, MD, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 28 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 4 IS - 1 SN - 1758-2946, 1758-2946 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Databases KW - Informatics KW - Statistics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272737969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=Effects+of+multiple+conformers+per+compound+upon+3-D+similarity+search+and+bioassay+data+analysis&rft.au=Kim%2C+Sunghwan%3BBolton%2C+Evan+E%3BBryant%2C+Stephen+H&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2012-01-01&rft.volume=4&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=17582946&rft_id=info:doi/10.1186%2F1758-2946-4-28 L2 - http://www.jcheminf.com/content/4/1/28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Number of references - 55 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - Databases; Statistics; Data processing; Informatics DO - http://dx.doi.org/10.1186/1758-2946-4-28 ER - TY - JOUR T1 - Effects of ultrasound and ultrasound contrast agent on vascular tissue AN - 1221146695; 17379405 AB - Background: Ultrasound (US) imaging can be enhanced using gas-filled microbubble contrast agents. Strong echo signals are induced at the tissue-gas interface following microbubble collapse. Applications include assessment of ventricular function and virtual histology. Aim: While ultrasound and US contrast agents are widely used, their impact on the physiological response of vascular tissue to vasoactive agents has not been investigated in detail. Methods and results: In the present study, rat dorsal aortas were treated with US via a clinical imaging transducer in the presence or absence of the US contrast agent, Optison. Aortas treated with both US and Optison were unable to contract in response to phenylephrine or to relax in the presence of acetylcholine. Histology of the arteries was unremarkable. When the treated aortas were stained for endothelial markers, a distinct loss of endothelium was observed. Importantly, terminal deoxynucleotidyl transferase mediated dUTP nick-end-labeling (TUNEL) staining of treated aortas demonstrated incipient apoptosis in the endothelium. Conclusions: Taken together, these ex vivo results suggest that the combination of US and Optison may alter arterial integrity and promote vascular injury; however, the in vivo interaction of Optison and ultrasound remains an open question. JF - Cardiovascular Ultrasound AU - Wood, Steven C AU - Antony, Sible AU - Brown, Ronald P AU - Chen, Jin AU - Gordon, Edward A AU - Hitchins, Victoria M AU - Zhang, Qin AU - Liu, Yunbo AU - Maruvada, Subha AU - Harris, Gerald R AD - Food and Drug Administration, Center for Devices and Radiological Health (CDRH), 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 29 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 10 IS - 1 SN - 1476-7120, 1476-7120 KW - Biotechnology and Bioengineering Abstracts KW - Acetylcholine KW - Aorta KW - Apoptosis KW - Arteries KW - Contrast media KW - DNA nucleotidylexotransferase KW - Endothelium KW - Injuries KW - Ultrasound KW - Vasoactive agents KW - imaging KW - phenylephrine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221146695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+Ultrasound&rft.atitle=Effects+of+ultrasound+and+ultrasound+contrast+agent+on+vascular+tissue&rft.au=Wood%2C+Steven+C%3BAntony%2C+Sible%3BBrown%2C+Ronald+P%3BChen%2C+Jin%3BGordon%2C+Edward+A%3BHitchins%2C+Victoria+M%3BZhang%2C+Qin%3BLiu%2C+Yunbo%3BMaruvada%2C+Subha%3BHarris%2C+Gerald+R&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=10&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+Ultrasound&rft.issn=14767120&rft_id=info:doi/10.1186%2F1476-7120-10-29 L2 - http://www.cardiovascularultrasound.com/content/10/1/29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Number of references - 49 N1 - Last updated - 2012-12-04 N1 - SubjectsTermNotLitGenreText - phenylephrine; Apoptosis; Injuries; Arteries; Aorta; Endothelium; Contrast media; Acetylcholine; imaging; Ultrasound; DNA nucleotidylexotransferase; Vasoactive agents DO - http://dx.doi.org/10.1186/1476-7120-10-29 ER - TY - JOUR T1 - Interventions to Promote an Integrated Approach to Public Health Problems: An Application to Childhood Obesity AN - 1221139126; 17366101 AB - Experts stress the need to bring the childhood obesity epidemic under control by means of an integrated approach. The implementation of such an approach requires the development of integrated enabling policies on public health by local governments. A prerequisite for developing such integrated public health policies is intersectoral collaboration. Since the development of integrated policies is still in its early stages, this study aimed to answer the following research question: "What interventions can promote intersectoral collaboration and the development of integrated health policies for the prevention of childhood obesity? " Data were collected through a literature search and observations of and interviews with stakeholders. Based on a theoretical framework, we categorized potential interventions that could optimize an integrated approach regarding children's physical activity and diet. The intervention categories included education, persuasion, incentivization, coercion, training, restriction, environmental restructuring, modeling, and enablement. JF - Journal of Environmental and Public Health AU - Hendriks, Anna-Marie AU - Gubbels, Jessica S AU - De Vries, Nanne K AU - Seidell, Jaap C AU - Kremers, Stef PJ AU - Jansen, Maria WJ AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, P.O. Box 2022, 6160 HA Geleen, The Netherlands, anna-marie.hendriks@maastrichtuniversity.nl Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-9805, 1687-9805 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Diets KW - Obesity KW - Stakeholders KW - Education KW - Physical activity KW - Intervention KW - Persuasion KW - Children KW - Public health KW - H 12000:Epidemiology and Public Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221139126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+and+Public+Health&rft.atitle=Interventions+to+Promote+an+Integrated+Approach+to+Public+Health+Problems%3A+An+Application+to+Childhood+Obesity&rft.au=Hendriks%2C+Anna-Marie%3BGubbels%2C+Jessica+S%3BDe+Vries%2C+Nanne+K%3BSeidell%2C+Jaap+C%3BKremers%2C+Stef+PJ%3BJansen%2C+Maria+WJ&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+and+Public+Health&rft.issn=16879805&rft_id=info:doi/10.1155%2F2012%2F913236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Diets; Stakeholders; Obesity; Education; Physical activity; Intervention; Persuasion; Children; Public health DO - http://dx.doi.org/10.1155/2012/913236 ER - TY - JOUR T1 - The effects of recall length and reporting aids on household reporting of health care events in the medical expenditure panel survey AN - 1171852086; 4364935 AB - We examined the effects of length of recall period and written records on the accuracy of household reports of health care use of Medicare beneficiaries in the Medical Expenditure Panel Survey (M EPS), a widely used nationally-representative federal survey. Our sample contained 1,375 Medicare beneficiaries with 5 complete rounds of MEPS interviews during 2001-2003 who were matched to their Medicare claims records. Household respondents systematically underreported any emergency department use per round (mean of 0.07 vs. 0.09 in the claims, p <0.001) and number of ambulatory visits per 90 days (2.3 vs. 2.7, p < 0.001). In logistic regressions, recall periods less than 2 months and, to a lesser extent, 3 to 4 months were associated with lower odds of underreporting visits and higher overall accuracy. Calendars and bills, insurance statements, and other records of health care events kept by some MEPS respondents also were associated with lower odds of underreporting. Adapted from the source document. Reprinted by permission of IOS Press JF - Journal of economic and social measurement AU - Zuvekas, Samuel H AD - Agency for Healthcare Research and Quality Y1 - 2012 PY - 2012 DA - 2012 SP - 321 EP - 343 VL - 36 IS - 4 SN - 0747-9662, 0747-9662 KW - Economics KW - Health economics KW - Health expenditure KW - Health care KW - Surveys KW - Medical treatment KW - Medicine KW - U.S.A. KW - Panel surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171852086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+economic+and+social+measurement&rft.atitle=The+effects+of+recall+length+and+reporting+aids+on+household+reporting+of+health+care+events+in+the+medical+expenditure+panel+survey&rft.au=Zuvekas%2C+Samuel+H&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2012-01-01&rft.volume=36&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+economic+and+social+measurement&rft.issn=07479662&rft_id=info:doi/10.3233%2FJEM-2011-0348 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7894; 12429; 5775 13521; 9149 12429; 5778 4025; 5780 4618; 7890 5792 10484; 433 293 14 DO - http://dx.doi.org/10.3233/JEM-2011-0348 ER - TY - JOUR T1 - Implementation of school health promotion: consequences for professional assistance AN - 1125282704; 201225676 AB - Purpose -- This case study aimed to examine the factors influencing the implementation of health promotion (HP) policies and programs in secondary schools and the consequences for professional assistance. Design/methodology/approach -- Group interviews were held in two schools that represented the best and worst case of implementation of a health promotion program ("Schoolbeat") in the Southern Limburg region. Both schools were represented by the school manager, the health care coordinator and their school health promotion (SHP) advisor. The main purpose of the group interview was to describe the organization of HP in the school. Findings -- Efforts to improve organizational aspects like change management, collaborative support and project management contributed to the implementation of HP. Practical implications -- Based on these results the authors advise SHP advisors to focus more on the organizational aspects of HP in schools. Originality/value -- This study contributes to the discussion about the tasks of HP professionals assisting secondary schools. Results show that effective assistance in shaping school health promotion requires competencies that go beyond organizing practical HP activities. HP professionals assisting schools need skills covering many aspects of the field, ranging from professional assistance for the process of implementing HP to organizational skills to advise and guide schools on the organizational changes needed for the implementation of HP. Adapted from the source document. JF - Health Education AU - Boot, N.M.W.M. AU - de Vries, N.K. AD - Department of Health Promotion, Regional Public Health Service (GGD) Southern Limburg, Geleen, The Netherlands nicole.boot@ggdzl.nl Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 436 EP - 447 PB - Emerald Group Publishing Ltd., Bradford UK VL - 112 IS - 5 SN - 0965-4283, 0965-4283 KW - School health promotion Secondary schools Schoolbeat approach Collaboration Health education Project management Change management KW - Advisers KW - Secondary schools KW - Institutional aspects KW - Project management KW - Methodology KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125282704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education&rft.atitle=Implementation+of+school+health+promotion%3A+consequences+for+professional+assistance&rft.au=Boot%2C+N.M.W.M.%3Bde+Vries%2C+N.K.&rft.aulast=Boot&rft.aufirst=N.M.W.M.&rft.date=2012-01-01&rft.volume=112&rft.issue=5&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Health+Education&rft.issn=09654283&rft_id=info:doi/10.1108%2F09654281211253443 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health promotion; Secondary schools; Institutional aspects; Advisers; Methodology; Project management DO - http://dx.doi.org/10.1108/09654281211253443 ER - TY - JOUR T1 - A validation study comparing two self-reported upper extremity symptom surveys with clinical examinations for upper extremity musculoskeletal disorders AN - 1113218274; 17253182 AB - Objective: Evaluate the validity of two self-report symptoms surveys with two disorder classification protocols.Participants: 100 graduate students at a private school in the Southwest United States.Methods: Study participants completed two self-report upper extremity musculoskeletal symptoms surveys: a nine item 10 cm Visual Analogue Scale (VAS) and a nine item Likert categorical scale anchored from "None" to "Very severe". Clinical examinations were administered using two musculoskeletal disorder classification protocols.Results: For the nine body regions, concordance between the two self-report symptoms scales ranged from 0.490.75. Overall there was greater than 80% agreement for the two disorder classification protocols. Using either symptom survey with either disorder classification protocol provided high sensitivities and specificities (Youden's J 0.70). Three of possible six symptom survey/classification protocol pairings provided high sensitivities and specificities across all disorder groups.Conclusion: In this graduate student sample, none of the self-report symptom survey-classification protocol pairings was demonstratively more useful than any other pairing for studies of musculoskeletal disorders among computer users. JF - Work AU - Amick, Benjamin C, III AU - Caroom, Cyrus AU - Katz, Jeffrey N AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 293 EP - 302 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG Netherlands VL - 43 IS - 3 SN - 1051-9815, 1051-9815 KW - Health & Safety Science Abstracts KW - Computing-related KW - graduate students KW - Youden's J KW - sensitivity KW - specificity KW - Sensitivity KW - Musculoskeletal system KW - Schools KW - Classification KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1113218274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Work&rft.atitle=A+validation+study+comparing+two+self-reported+upper+extremity+symptom+surveys+with+clinical+examinations+for+upper+extremity+musculoskeletal+disorders&rft.au=Amick%2C+Benjamin+C%2C+III%3BCaroom%2C+Cyrus%3BKatz%2C+Jeffrey+N&rft.aulast=Amick&rft.aufirst=Benjamin&rft.date=2012-01-01&rft.volume=43&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Work&rft.issn=10519815&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Sensitivity; Schools; Musculoskeletal system; Classification ER - TY - JOUR T1 - Trench Safety-Using a Qualitative Approach to Understand Barriers and Develop Strategies to Improve Trenching Practices AN - 1093469426; 17032738 AB - Despite efforts to ensure workplace safety and health, injuries and fatalities related to trenching and excavation remain alarmingly high in the construction industry. Because properly installed trenching protective systems can potentially reduce the significant number of trenching fatalities, there is clearly a need to identify the barriers to the use of these systems and to develop strategies to ensure these systems are utilized consistently. The current study reports on the results of focus groups with construction workers and safety management personnel to better understand these barriers and to identify solutions. The results suggest several factors, from poor planning to pressures from experienced workers and supervisors, which present barriers to safe trenching practices. Based on the results, it is recommended that safety trainings incorporate unique messages for new workers, experienced workers and management in an effort to motivate each group to work safely as well as provide them with solutions to overcome the identified barriers. JF - International Journal of Construction Education and Research AU - Flynn, Michael A AU - Sampson, Julie M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 63 EP - 79 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 8 IS - 1 SN - 1557-8771, 1557-8771 KW - Health & Safety Science Abstracts KW - Construction industry KW - Education KW - Injuries KW - Mortality KW - Training KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093469426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Construction+Education+and+Research&rft.atitle=Trench+Safety-Using+a+Qualitative+Approach+to+Understand+Barriers+and+Develop+Strategies+to+Improve+Trenching+Practices&rft.au=Flynn%2C+Michael+A%3BSampson%2C+Julie+M&rft.aulast=Flynn&rft.aufirst=Michael&rft.date=2012-01-01&rft.volume=8&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Construction+Education+and+Research&rft.issn=15578771&rft_id=info:doi/10.1080%2F15578771.2011.633973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Mortality; Education; Injuries; Training; Construction industry DO - http://dx.doi.org/10.1080/15578771.2011.633973 ER - TY - JOUR T1 - Effect of calibration and environmental condition on the performance of direct-reading organic vapor monitors. AN - 1081437097; 23016630 AB - The performance of three MIRAN SapphIRe Portable Infrared Ambient Air Analyzers and three Century Portable Toxic Vapor Analyzers equipped with photoionization (PID) and flame ionization (FID) detectors was compared with charcoal tube sampling. Relationships were investigated using two different calibration methods at four cyclohexane concentrations, three temperatures, and four relative humidities. For the first method, the TVA monitors were calibrated with a single concentration of methane for the FID, and isobutylene for the PID. The SapphIRe monitors were zeroed and the monitor's manufacturer-supplied library was used. For the second method, a five-point cyclohexane calibration curve was created for each monitor. Comparison of the monitor results of each calibration method (pooled data) indicated a significant difference between methods (t-test, p < 0.001), The SapphIRe group had results closer to the charcoal tubes with the second calibration method, while the PID and FID monitor groups performed better using the first calibration method. The PID monitor group's performance was affected only at the 90% relative humidity (RH) condition. Using the first method, the monitor readings were compared with the charcoal tube average using mixed linear model analyses of variance (ANOVAs) and regression. The ANOVA results showed there was a statistically significant difference among readings from all monitor types (p <0.0001). The regression results demonstrated that the SapphIRe (r² = 0.97) and FID (r² = 0.92) monitor groups correlated well with the charcoal tubes. The PID monitor group had a similar correlation when 90% RH was excluded (r² = 0.94) but had a weaker correlation when it was included (r² = 0.58). The operator should take care when using these monitors at high concentrations and the PID monitors at high humidities, consider the variability between units of the same monitor, and conduct performance verification of the monitor being used. JF - Journal of occupational and environmental hygiene AU - Coffey, Christopher AU - LeBouf, Ryan AU - Lee, Larry AU - Slaven, James AU - Martin, Stephen AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. ccc3@cdc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 670 EP - 680 VL - 9 IS - 11 KW - Air Pollutants, Occupational KW - 0 KW - Cyclohexanes KW - Cyclohexane KW - 48K5MKG32S KW - Index Medicus KW - False Negative Reactions KW - Analysis of Variance KW - Flame Ionization KW - Linear Models KW - Temperature KW - Photochemical Processes KW - Humidity KW - Calibration KW - False Positive Reactions KW - Air Pollutants, Occupational -- analysis KW - Cyclohexanes -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081437097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Effect+of+calibration+and+environmental+condition+on+the+performance+of+direct-reading+organic+vapor+monitors.&rft.au=Coffey%2C+Christopher%3BLeBouf%2C+Ryan%3BLee%2C+Larry%3BSlaven%2C+James%3BMartin%2C+Stephen&rft.aulast=Coffey&rft.aufirst=Christopher&rft.date=2012-01-01&rft.volume=9&rft.issue=11&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-02-22 N1 - Date created - 2012-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Exposure to Acrylamide in Closed System Production Plants: Air Levels and Biomonitoring AN - 1069195190; 17139332 AB - The aim of this study was to evaluate biomarkers of acrylamide exposure, including hemoglobin adducts and urinary metabolites in acrylamide production workers. Biomarkers are integrated measures of the internal dose, and it is total acrylamide dose from all routes and sources that may present health risks. Workers from three companies were studied. Workers potentially exposed to acrylamide monomer wore personal breathing-zone air samplers. Air samples and surface-wipe samples were collected and analyzed for acrylamide. General-area air samples were collected in chemical processing units and control rooms. Hemoglobin adducts were isolated from ethylenediamine teraacetic acid (EDTA)-whole blood, and adducts of acrylamide and glycidamide, at the N-terminal valines of hemoglobin, were cleaved from the protein chain by use of a modified Edman reaction. Full work-shift, personal breathing zone, and general-area air samples were collected and analyzed for particulate and acrylamide monomer vapor. The highest general-area concentration of acrylamide vapor was 350 mu g/cm3 in monomer production. Personal breathing zone and general-area concentrations of acrylamide vapor were found to be highest in monomer production operations, and lower levels were in the polymer production operations. Adduct levels varied widely among workers, with the highest in workers in the monomer and polymer production areas. The acrylamide adduct range was 15-1884 pmol/g; glycidamide adducts ranged from 17.8 to 1376 p/mol/g. The highest acrylamide and glycidamide adduct levels were found among monomer production process operators. The primary urinary metabolite N-acetyl-S-(2-carbamoylethyl) cysteine (NACEC) ranged from the limit of detection to 15.4 mu g/ml. Correlation of workplace exposure and sentinel health effects is needed to determine and control safe levels of exposure for regulatory standards. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Moorman, William J AU - Reutman, Susan S AU - Shaw, Peter B AU - Blade, Leo Michael AU - Marlow, David AU - Vesper, Hubert AU - Clark, John C AU - Schrader, Steven M AD - CDC-NIOSH, DART, EPHB, Cincinnati, Ohio, USA Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 100 EP - 111 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 75 IS - 2 SN - 1528-7394, 1528-7394 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Chemical process industry KW - Respiration KW - Metabolites KW - Particulates KW - Hemoglobin KW - Workers KW - Vapors KW - Air sampling KW - biomonitoring KW - Occupational exposure KW - Bioindicators KW - Adducts KW - Samplers KW - biomarkers KW - Monomers KW - Blood KW - Acrylamide KW - Urine KW - Cysteine KW - valine KW - Polymers KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1069195190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Occupational+Exposure+to+Acrylamide+in+Closed+System+Production+Plants%3A+Air+Levels+and+Biomonitoring&rft.au=Moorman%2C+William+J%3BReutman%2C+Susan+S%3BShaw%2C+Peter+B%3BBlade%2C+Leo+Michael%3BMarlow%2C+David%3BVesper%2C+Hubert%3BClark%2C+John+C%3BSchrader%2C+Steven+M&rft.aulast=Moorman&rft.aufirst=William&rft.date=2012-01-01&rft.volume=75&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.615109 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Adducts; Respiration; Metabolites; biomarkers; Samplers; Monomers; Hemoglobin; Workers; Blood; Vapors; Acrylamide; Cysteine; biomonitoring; valine; Occupational exposure; Bioindicators; Chemical process industry; Urine; Air sampling; Particulates; Polymers DO - http://dx.doi.org/10.1080/15287394.2011.615109 ER - TY - JOUR T1 - Qualitative determination of carbon black in food products AN - 1038614638; 17032568 AB - Carbon black (C.I. 77266) is an insoluble pigment produced by the partial combustion of hydrocarbons. The pigment is known by several synonyms, including vegetable carbon, lamp black and carbon ash, that correspond to the raw materials and methods used for its production. Vegetable carbon (E153) is permitted for use in colouring food in the European Union. The US Food and Drug Administration (USFDA) has not approved the use of any type of carbon black for colouring food, although the agency batch certifies the pigment as D&C Black No. 2 for use in colouring certain cosmetics. Since carbon black (as vegetable carbon) may be present in food products offered for import into the United States, the USFDA's district laboratories need a qualitative analytical method for determining its presence. We have developed an extraction method for this purpose. A sample is broken down and dissolved with nitric acid. The resulting solution is filtered and treated with hydrochloric acid to dissolve any black iron oxide also present as a colour additive. A black residue remaining on the filter paper indicates the presence of carbon black in the food. We confirmed the presence of carbon black in residues from several standards and food products using Raman spectroscopy. The limit of detection for this method is 0.0001%. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Miranda-Bermudez, E AU - Belai, N AU - Harp, BPetigara AU - Yakes, B J AU - Barrows, J N AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 38 EP - 42 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 29 IS - 1 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Black carbon KW - Combustion KW - Food additives KW - Iron KW - Nitric acid KW - Pigments KW - Raw materials KW - Residues KW - Risk assessment KW - USA KW - European Union KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038614638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Qualitative+determination+of+carbon+black+in+food+products&rft.au=Miranda-Bermudez%2C+E%3BBelai%2C+N%3BHarp%2C+BPetigara%3BYakes%2C+B+J%3BBarrows%2C+J+N&rft.aulast=Miranda-Bermudez&rft.aufirst=E&rft.date=2012-01-01&rft.volume=29&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.616535 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Black carbon; Residues; Pigments; Nitric acid; Iron; Raw materials; Combustion; USA; European Union DO - http://dx.doi.org/10.1080/19440049.2011.616535 ER - TY - GEN T1 - Managing Chronic Pain in Adults with or in Recovery from Substance Use Disorders. Treatment Improvement Protocol (TIP) Series 54 AN - 1037906806; ED533525 AB - Chronic noncancer pain (CNCP) is common in the general population as well as in people who have a substance use disorder (SUD) (Exhibit 1-1). Chronic pain is not harmless; it has physiological, social, and psychological dimensions that can seriously harm health, functioning, and well-being. As a multidimensional condition with both objective and subjective aspects, CNCP is difficult to assess and treat. Although CNCP can be managed, it usually cannot be completely eliminated. When patients with CNCP have comorbid SUD or are recovering from SUD, a complex condition becomes even more difficult to manage. This Treatment Improvement Protocol (TIP) is for primary care providers who treat or are likely to treat adult patients with or in recovery from SUDs who present with CNCP. Given the prevalence of CNCP in the population, this audience includes virtually all primary care providers. Addiction specialists, psychiatrists, nurses, and other clinicians may find information here that will help them ensure that their patients with CNCP receive adequate pain treatment. By providing a shared basic understanding of and a common language for these two chronic conditions, this TIP facilitates cooperation and communication between healthcare professionals treating pain and those treating addiction. This TIP equips clinicians with practical guidance and tools for treating CNCP in adults with histories of SUDs. It provides readers with information about SUD assessments and referrals for further evaluation. For patients with histories of SUDs, the most controversial and possibly hazardous pain treatment in widespread use is opioid treatment. For this reason, this topic receives significant attention in Chapters 3 and 4. Appended are: (1) Bibliography; (2) Assessment Tools and Resources; (3) CFR Sample Consent Form and List of Personal Identifiers; (4) Resources for Finding Complementary and Alternative Therapy Practitioners; (5) Field Reviewers; and (6) Acknowledgments. A section on patient education is also included as well as an index. (Contains 50 exhibits.) Y1 - 2012 PY - 2012 DA - 2012 SP - 128 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Support Staff KW - Substance Abuse KW - Clinical Diagnosis KW - Chronic Illness KW - Pain KW - Adults KW - Patient Education KW - Comorbidity KW - Outcomes of Treatment KW - Evaluation Methods KW - Compliance (Psychology) KW - Health Behavior KW - Coping KW - Neurology KW - At Risk Persons KW - Drug Therapy KW - Physical Therapy KW - Screening Tests KW - Family Involvement KW - Addictive Behavior KW - Counseling Techniques KW - Behavior Modification KW - Guides KW - Cognitive Restructuring KW - Drug Rehabilitation KW - Internet KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037906806?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats AN - 1031310006; 16809023 AB - Silicon nanowires (Si NWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 mu g of Si NW (~20-30 nm diameter; ~2-15 mu m length). Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment. Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time. At day 91 after treatment with the highest doses, lung collagen was increased. Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages. In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung. JF - Journal of Nanomaterials AU - Roberts, Jenny R AU - Mercer, Robert R AU - Chapman, Rebecca S AU - Cohen, Guy M AU - Bangsaruntip, Sarunya AU - Schwegler-Berry, Diane AU - Scabilloni, James F AU - Castranova, Vincent AU - Antonini, James M AU - Leonard, Stephen S AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, jur6@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-4110, 1687-4110 KW - Toxicology Abstracts KW - Macrophages KW - Silicon KW - Injuries KW - Lung KW - Circuits KW - Toxicity KW - nanotechnology KW - Collagen KW - Models KW - Inflammation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1031310006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanomaterials&rft.atitle=Pulmonary+Toxicity%2C+Distribution%2C+and+Clearance+of+Intratracheally+Instilled+Silicon+Nanowires+in+Rats&rft.au=Roberts%2C+Jenny+R%3BMercer%2C+Robert+R%3BChapman%2C+Rebecca+S%3BCohen%2C+Guy+M%3BBangsaruntip%2C+Sarunya%3BSchwegler-Berry%2C+Diane%3BScabilloni%2C+James+F%3BCastranova%2C+Vincent%3BAntonini%2C+James+M%3BLeonard%2C+Stephen+S&rft.aulast=Roberts&rft.aufirst=Jenny&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanomaterials&rft.issn=16874110&rft_id=info:doi/10.1155%2F2012%2F398302 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 37 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Silicon; Injuries; Lung; Circuits; Toxicity; Inflammation; Models; Collagen; nanotechnology DO - http://dx.doi.org/10.1155/2012/398302 ER - TY - JOUR T1 - Despite 2007 Law Requiring FDA Hotline To Be Included In Print Drug Ads, Reporting Of Adverse Events By Consumers Still Low AN - 1030885928; 2011-304176 AB - In 2007 the federal government began requiring drug makers to include in their print direct-to-consumer advertisements information for consumers on how to contact the Food and Drug Administration directly, either by phone or through the agency's website, to report any adverse events that they experienced after taking a prescription drug. Adverse events can range from minor skin problems like itching to serious injuries or illness that result in hospitalization, permanent disability, or even death. Even so, current rates of adverse event reporting are low. We studied adverse event reports about 123 drugs that came from patients before and after the enactment of the print advertising requirement and estimated that requirement's impact with model simulations. We found that if monthly spending on print direct-to-consumer advertising increased from zero to $7.7 million per drug, the presence of the Food and Drug Administration contact information tripled the increase in patient-reported adverse events, compared to what would have happened in the absence of the law. However, the absolute monthly increase was fewer than 0.24 reports per drug, suggesting that the public health impact of the increase was small and that the adverse event reporting rate would still be low. The study results suggest that additional measures, such as more publicity about the Adverse Event Reporting System or more consumer education, should be considered to promote patient reporting of adverse events. Adapted from the source document. JF - Health Affairs AU - Du, Dongyi "Tony" AU - Goldsmith, John AU - Aikin, Kathryn J AU - Encinosa, William E AU - Nardinelli, Clark AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland dongyi.du@fda.hhs.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 1022 EP - 1029 PB - Project HOPE, Bethesda MD VL - 31 IS - 5 SN - 0278-2715, 0278-2715 KW - Business and service sector - Markets, marketing, and merchandising KW - Manufacturing and heavy industry - Container industry KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Economic conditions and policy - Economic policy, planning, and development KW - Law and ethics - Law and jurisprudence KW - Economic conditions and policy - Consumers and consumption KW - Business and service sector - Advertising and public relations KW - Health conditions and policy - Health and health policy KW - United States Food and drug administration KW - Labels KW - Marketing KW - Pharmaceutical industry KW - Advertising KW - Regulation KW - Consumer protection KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030885928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Despite+2007+Law+Requiring+FDA+Hotline+To+Be+Included+In+Print+Drug+Ads%2C+Reporting+Of+Adverse+Events+By+Consumers+Still+Low&rft.au=Du%2C+Dongyi+%22Tony%22%3BGoldsmith%2C+John%3BAikin%2C+Kathryn+J%3BEncinosa%2C+William+E%3BNardinelli%2C+Clark&rft.aulast=Du&rft.aufirst=Dongyi&rft.date=2012-01-01&rft.volume=31&rft.issue=5&rft.spage=1022&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Marketing; Labels; Pharmaceutical industry; United States Food and drug administration; Regulation; Consumer protection; Advertising; Public health ER - TY - JOUR T1 - Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos AN - 1028034885; 16884942 AB - Background: Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurring asbestos fibers which are known to be extremely pathogenic. While the toxicity and hazardous outcomes elicited by airborne exposure to single-walled CNT or asbestos have been widely reported, very limited data are currently available describing adverse effects of respirable CNF. Results: Here, we assessed pulmonary inflammation, fibrosis, oxidative stress markers and systemic immune responses to respirable CNF in comparison to single-walled CNT (SWCNT) and asbestos. Pulmonary inflammatory and fibrogenic responses to CNF, SWCNT and asbestos varied depending upon the agglomeration state of the particles/fibers. Foci of granulomatous lesions and collagen deposition were associated with dense particle-like SWCNT agglomerates, while no granuloma formation was found following exposure to fiber-like CNF or asbestos. The average thickness of the alveolar connective tissue - a marker of interstitial fibrosis - was increased 28 days post SWCNT, CNF or asbestos exposure. Exposure to SWCNT, CNF or asbestos resulted in oxidative stress evidenced by accumulations of 4-HNE and carbonylated proteins in the lung tissues. Additionally, local inflammatory and fibrogenic responses were accompanied by modified systemic immunity, as documented by decreased proliferation of splenic T cells ex vivo on day 28 post exposure. The accuracies of assessments of effective surface area for asbestos, SWCNT and CNF (based on geometrical analysis of their agglomeration) versus estimates of mass dose and number of particles were compared as predictors of toxicological outcomes. Conclusions: We provide evidence that effective surface area along with mass dose rather than specific surface area or particle number are significantly correlated with toxicological responses to carbonaceous fibrous nanoparticles. Therefore, they could be useful dose metrics for risk assessment and management. JF - Particle and Fibre Toxicology AU - Murray, Ashley R AU - Kisin, Elena R AU - Tkach, Alexey V AU - Yanamala, Naveena AU - Mercer, Robert AU - Young, Shih-Houng AU - Fadeel, Bengt AU - Kagan, Valerian E AU - Shvedova, Anna A AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 10 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Asbestos KW - Fibrosis KW - Connective tissues KW - Surface area KW - Spleen KW - Toxicity KW - Granuloma KW - Alveoli KW - Inflammation KW - Collagen KW - Fibers KW - Carbon KW - Oxidative stress KW - Lung KW - Lymphocytes T KW - nanotubes KW - Immune response KW - nanoparticles KW - Agglomeration KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028034885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Factoring-in+agglomeration+of+carbon+nanotubes+and+nanofibers+for+better+prediction+of+their+toxicity+versus+asbestos&rft.au=Murray%2C+Ashley+R%3BKisin%2C+Elena+R%3BTkach%2C+Alexey+V%3BYanamala%2C+Naveena%3BMercer%2C+Robert%3BYoung%2C+Shih-Houng%3BFadeel%2C+Bengt%3BKagan%2C+Valerian+E%3BShvedova%2C+Anna+A&rft.aulast=Murray&rft.aufirst=Ashley&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-9-10 L2 - http://www.particleandfibretoxicology.com/content/9/1/10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 57 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Asbestos; Connective tissues; Fibrosis; Surface area; Spleen; Toxicity; Granuloma; Alveoli; Collagen; Inflammation; Fibers; Carbon; Lung; Oxidative stress; Lymphocytes T; nanotubes; Immune response; nanoparticles; Agglomeration DO - http://dx.doi.org/10.1186/1743-8977-9-10 ER - TY - JOUR T1 - Velocity model determination for accurate location of mining-induced seismic events AN - 1026860977; 2012-067688 AB - Determining the location of mining-induced seismic events is strongly dependent on having an accurate velocity model. However, such a model is seldom available. This paper describes the determination of a velocity model for seismic event location, using the seismic events themselves as sources whose location is to be determined along with the parameters of the velocity model (a simultaneous inversion of event locations and velocity structure). Seismic monitoring of a mine in Colorado is used as an example, with an array of geophones installed both on the surface and in underground roadways. Velocity models of increasing complexity are considered, starting with a homogeneous velocity, moving to a (slightly dipping) layered-earth model, and eventually including static time shifts to account for the effects of a weathered, near-surface, low-velocity layer on arrival times at geophones mounted on the surface, This series of increasingly complex models obviously shows increasingly better fits to the data, but also shows more plausible event locations, and with more realistic elevation spans. Examination of spatial patters in the residuals indicates that there are likely mining-induced changes in velocity that are not accounted for in the model. JF - ASEG Extended Abstracts AU - King, Andrew AU - Anonymous Y1 - 2012 PY - 2012 DA - 2012 SP - 4 PB - CSIRO Publishing for the Australian Society of Exploration Geophysicists, Collingwood, Victoria VL - 2012 IS - 1 KW - mining KW - geologic hazards KW - underground mining KW - Bayesian analysis KW - statistical analysis KW - data processing KW - mathematical models KW - layered earth model KW - inverse problem KW - sedimentary rocks KW - seismicity KW - seismic risk KW - natural hazards KW - velocity KW - focus KW - static corrections KW - heterogeneity KW - induced earthquakes KW - earthquakes KW - accuracy KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1026860977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASEG+Extended+Abstracts&rft.atitle=Velocity+model+determination+for+accurate+location+of+mining-induced+seismic+events&rft.au=King%2C+Andrew%3BAnonymous&rft.aulast=King&rft.aufirst=Andrew&rft.date=2012-01-01&rft.volume=2012&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ASEG+Extended+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - ASEG 2012; 22nd international geophysical conference and exhibition N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2012-01-01 N1 - Number of references - 6 N1 - PubXState - Victoria N1 - Document feature - illus. N1 - SuppNotes - Summary also published in Preview, Vol. 156, Feb. 2012, p. 103-104 N1 - Last updated - 2012-07-19 N1 - CODEN - #07605 N1 - SubjectsTermNotLitGenreText - accuracy; Bayesian analysis; data processing; earthquakes; focus; geologic hazards; heterogeneity; induced earthquakes; inverse problem; layered earth model; mathematical models; mining; natural hazards; sedimentary rocks; seismic risk; seismicity; static corrections; statistical analysis; underground mining; velocity ER - TY - JOUR T1 - Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania AN - 1024666650; 16862535 AB - Background: Nitrate is a widespread contaminant of drinking water supplies, especially in agricultural areas. Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function. Methods: We assessed the relation of estimated nitrate levels in well water supplies with thyroid health in a cohort of 2,543 Old Order Amish residing in Lancaster, Chester, and Lebanon counties in Pennsylvania for whom thyroid stimulating hormone (TSH) levels were measured during 1995-2008. Nitrate measurement data (1976-2006) for 3,613 wells in the study area were obtained from the U.S. Geological Survey and we used these data to estimate concentrations at study participants' residences using a standard linear mixed effects model that included hydrogeological covariates and kriging of the wells' residuals. Nitrate levels estimated by the model ranged from 0.35 mg/L to 16.4 mg/L N-NO sub(3) super(-), with a median value of 6.5 mg/L, which was used as the cutpoint to define high and low nitrate exposure. In a validation analysis of the model, we calculated that the sensitivity of the model was 67% and the specificity was 93%. TSH levels were used to define the following outcomes: clinical hyperthyroidism (n = 10), clinical hypothyroidism (n = 56), subclinical hyperthyroidism (n = 25), and subclinical hypothyroidism (n = 228). Results: In women, high nitrate exposure was significantly associated with subclinical hypothyroidism (OR = 1.60; 95% CI: 1.11-2.32). Nitrate was not associated with subclinical thyroid disease in men or with clinical thyroid disease in men or women. Conclusions: Although these data do not provide strong support for an association between nitrate in drinking water and thyroid health, our results do suggest that further exploration of this hypothesis is warranted using studies that incorporate individual measures of both dietary and drinking water nitrate intake. JF - Environmental Health (London) AU - Aschebrook-Kilfoy, Briseis AU - Heltshe, Sonya L AU - Nuckols, John R AU - Sabra, Mona M AU - Shuldiner, Alan R AU - Mitchell, Braxton D AU - Airola, Matt AU - Holford, Theodore R AU - Zhang, Yawei AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 6 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1476-069X, 1476-069X KW - Health & Safety Science Abstracts KW - Diets KW - Nitrates KW - iodides KW - USA, Pennsylvania KW - geological surveys KW - Lebanon KW - Thyroid KW - Water wells KW - Drinking water KW - Water supplies KW - Hormones KW - H 3000:Environment and Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024666650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+%28London%29&rft.atitle=Modeled+nitrate+levels+in+well+water+supplies+and+prevalence+of+abnormal+thyroid+conditions+among+the+Old+Order+Amish+in+Pennsylvania&rft.au=Aschebrook-Kilfoy%2C+Briseis%3BHeltshe%2C+Sonya+L%3BNuckols%2C+John+R%3BSabra%2C+Mona+M%3BShuldiner%2C+Alan+R%3BMitchell%2C+Braxton+D%3BAirola%2C+Matt%3BHolford%2C+Theodore+R%3BZhang%2C+Yawei%3BWard%2C+Mary+H&rft.aulast=Aschebrook-Kilfoy&rft.aufirst=Briseis&rft.date=2012-01-01&rft.volume=11&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+%28London%29&rft.issn=1476069X&rft_id=info:doi/10.1186%2F1476-069X-11-6 L2 - http://www.ehjournal.net/content/11/1/6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 33 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Diets; Nitrates; iodides; geological surveys; Thyroid; Water wells; Drinking water; Hormones; Water supplies; USA, Pennsylvania; Lebanon DO - http://dx.doi.org/10.1186/1476-069X-11-6 ER - TY - JOUR T1 - Rural-Urban Trends and Patterns in Cervical Cancer Mortality, Incidence, Stage, and Survival in the United States, 1950-2008 AN - 1023031560; 201204523 AB - This study examined disparities in cervical cancer mortality rates among US women in metropolitan and non-metropolitan areas from 1950 through 2007. Inequalities in incidence, stage of disease at diagnosis, and patient survival were analyzed during 2000-2008. Age-adjusted mortality, incidence, and 5-year relative survival rates were calculated for women in metropolitan and non-metropolitan areas, and differences in relative risks were tested for statistical significance. Log-linear regression was used to analyze annual rates of change in mortality over time. During the last five decades, women in non-metropolitan areas had significantly higher cervical cancer mortality than those in metropolitan areas. Disparities persisted against a backdrop of consistently declining mortality rates. Throughout 1969-2007, both white and black women in non-metropolitan areas maintained significantly higher cervical cancer mortality rates than their metropolitan counterparts. Among black women, cervical cancer mortality declined at a faster pace in metropolitan than in non-metropolitan areas. In both metropolitan and non-metropolitan areas, black women had twice the mortality rate of white women. During 2000-2008, white, black, and American Indian women in non-metropolitan areas had significantly higher cervical cancer incidence rates than their metropolitan counterparts. Survival rates were significantly lower in non-metropolitan areas, particularly among rural black women. The 5-year survival rate for black women diagnosed with cervical cancer was 50.8% in non-metropolitan areas, compared with 60.2% for black women and 71.0% for white women in metropolitan areas. Disparities in survival existed after controlling for disease stage. Rural-urban disparities in cervical cancer have persisted despite steep declines in incidence and mortality rates. Adapted from the source document. JF - Journal of Community Health AU - Singh, Gopal K AD - US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA gsingh@hrsa.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 217 EP - 223 PB - Springer, New York NY VL - 37 IS - 1 SN - 0094-5145, 0094-5145 KW - Mortality Rates KW - Black White Relations KW - Inequality KW - United States of America KW - Diseases KW - Racial Differences KW - Females KW - Metropolitan Areas KW - Cancer KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023031560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Rural-Urban+Trends+and+Patterns+in+Cervical+Cancer+Mortality%2C+Incidence%2C+Stage%2C+and+Survival+in+the+United+States%2C+1950-2008&rft.au=Singh%2C+Gopal+K&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2012-01-01&rft.volume=37&rft.issue=1&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-011-9439-6 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Mortality Rates; Females; Cancer; Racial Differences; Metropolitan Areas; Black White Relations; United States of America; Diseases; Inequality DO - http://dx.doi.org/10.1007/s10900-011-9439-6 ER - TY - JOUR T1 - Measuring juvenile delinquency: How do self-reports compare with official police statistics? AN - 1023029773; 201226697 AB - The accuracy of measuring the prevalence of delinquency by means of self-reported questionnaires is difficult to evaluate. This study assesses the differential validity of self-reported delinquency in adolescents and, more specifically, self-reported police contacts because of suspected misconduct. This study was conducted as part of the Rotterdam Youth Monitor, a youth health surveillance system. Self-report data of pupils (mainly 12-15 years old) in the first or third grade of secondary school in the school years 2007-8 and 2008-9 (n = 23,914) were merged with police data. Of the pupils registered as a suspect, 62 percent admitted to having been interrogated at the police station. However, there were differences between groups. Multivariate analysis showed that Moroccan pupils and first-grade pupils were more likely to give an invalid response. Pupils who were registered for theft, vandalism or assault were more likely to give a valid response, whereas pupils who were registered for an offence involving fireworks were more likely to give an invalid response. We conclude that using only self-reported data to measure delinquency in an ethnically diverse population results in substantial bias. It is advisable to use multiple sources to measure the prevalence of delinquency. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - European Journal of Criminology AU - van Batenburg-Eddes, Tamara AU - Butte, Dick AU - van de Looij-Jansen, Petra AU - Schiethart, Wiet AU - Raat, Hein AU - de Waart, Frouwkje AU - Jansen, Wilma AD - Rotterdam-Rijnmond Public Health Service, The Netherlands Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 23 EP - 37 PB - Sage Publications, London UK VL - 9 IS - 1 SN - 1477-3708, 1477-3708 KW - adolescents delinquency validity KW - Racism KW - Rotterdam, Netherlands KW - Juvenile Delinquency KW - Assault KW - Police KW - Students KW - Adolescents KW - Secondary Schools KW - Youth KW - article KW - 2147: social problems and social welfare; sociology of crime UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023029773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Criminology&rft.atitle=Measuring+juvenile+delinquency%3A+How+do+self-reports+compare+with+official+police+statistics%3F&rft.au=van+Batenburg-Eddes%2C+Tamara%3BButte%2C+Dick%3Bvan+de+Looij-Jansen%2C+Petra%3BSchiethart%2C+Wiet%3BRaat%2C+Hein%3Bde+Waart%2C+Frouwkje%3BJansen%2C+Wilma&rft.aulast=van+Batenburg-Eddes&rft.aufirst=Tamara&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Criminology&rft.issn=14773708&rft_id=info:doi/10.1177%2F1477370811421644 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Students; Police; Youth; Racism; Assault; Rotterdam, Netherlands; Secondary Schools; Adolescents; Juvenile Delinquency DO - http://dx.doi.org/10.1177/1477370811421644 ER - TY - JOUR T1 - Human exposures to pesticides in the United States. AN - 1022379524; 22732070 AB - Pesticides are used in most homes, businesses, and farms to control a variety of pests, including insects, weeds, fungi, rodents, and even microbial organisms. Inappropriate use of pesticides can lead to adverse effects to humans and the environment. This study provides updated information on the magnitude of adverse pesticide exposures in the United States. Data on pesticide exposure were obtained from calls to poison control centers (PCCs) reported by the American Association of Poison Control Centers. Estimates of emergency department visits, hospitalizations, and health care costs were reported by the Agency for Healthcare Research and Quality (AHRQ), and deaths from pesticide poisonings reported by the Centers for Disease Control and Prevention (CDC) WONDER (Wide-ranging Online Data for Epidemiologic Research). An average of 23 deaths occur each year with pesticides as the underlying cause of death, most due to suicidal ingestions. An average of 130,136 calls to poison control centers were reported from 2006 to 2010, with an average of 20,116 cases (17.8%) treated in health care facilities annually. AHQR reported an annual average of 7385 emergency room visits during 2006 to 2008, and 1419 annual hospitalizations during 2005 to 2009. Excluding cost from lost work time, hospital physician fees, and pesticide-induced cancers, the annual national cost associated with pesticide exposures was estimated as nearly $200 million USD based on data from emergency department visits, hospitalizations, and for deaths. Pesticide exposures remain a significant public health issue. Health care providers, cooperative extension agents, and pesticide manufactures can help prevent exposures by increasing education of parents and workers, encourage use of less toxic agents, and encourage the practice of integrated pest management. JF - Journal of agromedicine AU - Langley, Ricky L AU - Mort, Sandra Amiss AD - North Carolina Department of Health and Human Services, Division of Public Health, Raleigh, North Carolina 27699-1912, USA. rick.langley@dhhs.nc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 300 EP - 315 VL - 17 IS - 3 KW - Pesticides KW - 0 KW - Index Medicus KW - United States KW - Young Adult KW - Public Health KW - Humans KW - Emergency Service, Hospital -- statistics & numerical data KW - Child KW - Hospitalization -- statistics & numerical data KW - Adolescent KW - Health Care Costs KW - Poison Control Centers -- statistics & numerical data KW - Pesticides -- poisoning KW - Poisoning -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022379524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Human+exposures+to+pesticides+in+the+United+States.&rft.au=Langley%2C+Ricky+L%3BMort%2C+Sandra+Amiss&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2012-01-01&rft.volume=17&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F1059924X.2012.688467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-11-30 N1 - Date created - 2012-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/1059924X.2012.688467 ER - TY - JOUR T1 - Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure AN - 1017966797; 16575159 AB - OBJECTIVES: Prior investigations identified an association between airborne cadmium and lung cancer but questions remain regarding confounding by arsenic, a well-established lung carcinogen. METHODS: A cadmium smelter population exhibiting excess lung cancer was re-analysed using a retrospective exposure assessment for arsenic (As), updated mortality (1940-2002), a revised cadmium (Cd) exposure matrix and improved work history information. RESULTS: Cumulative exposure metrics for both cadmium and arsenic were strongly associated making estimation of their independent effects difficult. Standardised mortality ratios (SMRs) were modelled with Poisson regression with the contribution of arsenic to lung cancer risk constrained by exposure-response estimates previously reported. The results demonstrate (1) a statistically significant effect of Cd independent of As (SMR=3.2 for 10 mg-year/m3 Cd, p=0.012), (2) a substantial healthy worker effect for lung cancer (for unexposed workers, SMR=0.69) and (3) a large deficit in lung cancer mortality among Hispanic workers (SMR=0.27, p=0.009), known to have low lung cancer rates. A supralinear dose-rate effect was observed (contribution to risk with increasing exposure intensity has declining positive slope). Lung cancer mortality was somewhat better predicted using a cadmium burden metric with a half-life of about 20-25 years. CONCLUSIONS: These findings support an independent effect for cadmium in risk of lung cancer mortality. 1/1000 excess lifetime risk of lung cancer death is predicted from an airborne exposure of about 2.4 mu g/m3 Cd. JF - Occupational and Environmental Medicine AU - Park, Robert M AU - Stayner, Leslie T AU - Petersen, Martin R AU - Finley-Couch, Melissa AU - Hornung, Richard AU - Rice, Carol AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 303 EP - 309 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 69 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Arsenic KW - Dose-response effects KW - Carcinogens KW - Smelters KW - Cancer KW - Occupational exposure KW - Ethnic groups KW - Lung cancer KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Cadmium+and+lung+cancer+mortality+accounting+for+simultaneous+arsenic+exposure&rft.au=Park%2C+Robert+M%3BStayner%2C+Leslie+T%3BPetersen%2C+Martin+R%3BFinley-Couch%2C+Melissa%3BHornung%2C+Richard%3BRice%2C+Carol&rft.aulast=Park&rft.aufirst=Robert&rft.date=2012-01-01&rft.volume=69&rft.issue=5&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; Arsenic; Dose-response effects; Carcinogens; Smelters; Ethnic groups; Occupational exposure; Cancer; Lung cancer ER - TY - JOUR T1 - Animal-related injuries resulting in emergency department visits and hospitalizations in the United States, 2006-2008 AN - 1011215928; 16579081 AB - This paper presents information on emergency department (ED) visits and hospitalizations resulting from an animal-caused injury from 2006 to 2008 using data collected from the Agency for Healthcare Research and Quality. Information on the number of ED visits and hospitalizations from adverse animal encounters, the types of injuries resulting from such encounters, and the therapeutic procedures performed to treat injured persons from bites or stings caused by various species of animals are presented. The economic costs of animal-caused injuries also are discussed. Over 1 million hospital ED visits and 48,000 hospitalizations were reported annually in the United States due to an animal-caused injury during this time period. Infections resulting from non-venomous animal bites were the major cause of hospital admissions. The estimated cost of these visits, excluding physician fees during hospitalization, exceeded $2 billion annually. Many animal-related injuries can be prevented if advice from wildlife agencies or the Centers for Disease Control and Prevention were heeded. JF - Human-Wildlife Interactions AU - Langley, R L AD - North Carolina Department of Health and Human Services, 1912 Mail Service Center, Raleigh, NC 27699-1912, USA, rick.langley@dhhs.nc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 123 EP - 136 VL - 6 IS - 1 SN - 2155-3858, 2155-3858 KW - Animal Behavior Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - Bites KW - Data processing KW - Disease control KW - Economics KW - Health care KW - Hospitals KW - Infection KW - Injuries KW - Stings KW - Wildlife KW - bites KW - emergency medical services KW - fees KW - infection KW - USA KW - Y 25150:General/Miscellaneous KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011215928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human-Wildlife+Interactions&rft.atitle=Animal-related+injuries+resulting+in+emergency+department+visits+and+hospitalizations+in+the+United+States%2C+2006-2008&rft.au=Langley%2C+R+L&rft.aulast=Langley&rft.aufirst=R&rft.date=2012-01-01&rft.volume=6&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Human-Wildlife+Interactions&rft.issn=21553858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Data processing; Stings; Injuries; Bites; Wildlife; Economics; Disease control; Infection; Hospitals; Health care; bites; infection; fees; emergency medical services; USA ER - TY - JOUR T1 - Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation AN - 1010707830; 201208177 AB - Background: Accurate identification of nonverbal emotional cues is essential to successful social interactions, yet most research is limited to emotional face expression labeling. Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations. Methods: Using the Diagnostic Analysis of Nonverbal Accuracy, the current study examined whether youths with pediatric-onset bipolar disorder (BD) and/or those with chronic and severe irritability (i.e. the severe mood dysregulation phenotype) are impaired in their ability to identify the emotional prosody of a spoken sentence with neutral content. Results: Youths with severe mood dysregulation (n=67) performed more poorly than healthy comparison children (n=57), even when the sample was limited to unmedicated patients. Medicated BD youths (n=52) exhibited impairment relative to healthy comparison children. No interactions between group and emotion were observed, suggesting that emotional prosody labeling problems may represent a general deficit in chronically irritable youths and in medicated youths with BD. Conclusion: In concert with previously documented facial emotion labeling deficits, difficulties ascertaining the correct emotional tone of a spoken sentence may contribute to emotion dysregulation in chronically irritable children, and possibly also in youths with BD. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Deveney, Christen M AU - Brotman, Melissa A AU - Decker, Ann Marie AU - Pine, Daniel S AU - Leibenluft, Ellen AD - Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 262 EP - 270 PB - Blackwell Publishing, Oxford UK VL - 53 IS - 3 SN - 0021-9630, 0021-9630 KW - Chronically KW - Bipolar affective disorder KW - Moods KW - Young people KW - Children KW - Prosody KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Affective+prosody+labeling+in+youths+with+bipolar+disorder+or+severe+mood+dysregulation&rft.au=Deveney%2C+Christen+M%3BBrotman%2C+Melissa+A%3BDecker%2C+Ann+Marie%3BPine%2C+Daniel+S%3BLeibenluft%2C+Ellen&rft.aulast=Deveney&rft.aufirst=Christen&rft.date=2012-01-01&rft.volume=53&rft.issue=3&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2011.02482.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Young people; Prosody; Moods; Children; Bipolar affective disorder; Chronically DO - http://dx.doi.org/10.1111/j.1469-7610.2011.02482.x ER - TY - JOUR T1 - Pharmacokinetics of Bisphenol A in neonatal and adult CD-1 mice: Inter-species comparisons with Sprague-Dawley rats and rhesus monkeys AN - 911154226; 15965319 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure at levels largely below 1 mu g/kg bw/d. The current study used LC/MS/MS to measure serum pharmacokinetics of unconjugated (active) and conjugated (inactive) BPA in adult and neonatal CD-1 mice by oral and subcutaneous (SC) injection routes. Deuterated BPA was used to avoid issues of background contamination. Significant inverse relationships were observed between postnatal age and measures of internal exposures (Cmax) to unconjugated BPA after oral administration. Phase II conjugation, area under the time-concentration curve (AUC), and elimination half-time of unconjugated BPA were also inversely related to age. In postnatal day (PND) 3 mice, the combination of under-developed Phase II metabolism, rapid absorption, and slow elimination kinetics led to equivalent internal exposures for unconjugated BPA from oral and SC routes; however, maturing metabolic capabilities in PND 10 and older mice, led to large and significant route effects. The significant inverse age-related developmental profiles from PND 3 through adulthood for unconjugated BPA internal exposure metrics from oral administration to CD-1 mice and Sprague-Dawley rats were remarkably similar; however, the developmental profile was quite different for neonatal rhesus monkeys in which small insignificant age-related differences were observed. These results suggest that an adverse effect from BPA observed in rodent models, attributable to exposure during a discrete time period of neonatal development, would be less likely for comparable neonatal primate dosing based on internal dosimetry. On the other hand in all adults of all species studied, including humans, a low oral dose of BPA produced similarly small internal exposures for the unconjugated form, reflecting the dominant effect of presystemic Phase II metabolism. JF - Toxicology Letters AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States, daniel.doerge@fda.hhs.gov Y1 - 2011/12/15/ PY - 2011 DA - 2011 Dec 15 SP - 298 EP - 305 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 207 IS - 3 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Bisphenol A KW - Estrogen receptors KW - Mass spectrometry KW - Pharmacokinetics KW - Age KW - Food KW - Dosimetry KW - Oral administration KW - Metabolites KW - Food contamination KW - Primates KW - Urine KW - Kinetics KW - Macaca mulatta KW - Neonates KW - Plastics KW - polycarbonate KW - Metabolism KW - Side effects KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Pharmacokinetics+of+Bisphenol+A+in+neonatal+and+adult+CD-1+mice%3A+Inter-species+comparisons+with+Sprague-Dawley+rats+and+rhesus+monkeys&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2011-12-15&rft.volume=207&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Food; Dosimetry; Oral administration; Metabolites; Food contamination; Pharmacokinetics; Bisphenol A; Urine; Kinetics; Plastics; Neonates; Side effects; Metabolism; polycarbonate; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.toxlet.2011.09.020 ER - TY - JOUR T1 - Hair dye use and risk of bladder cancer in the New England bladder cancer study AN - 1017962672; 16689667 AB - Aromatic amine components in hair dyes and polymorphisms in genes that encode enzymes responsible for hair dye metabolism may be related to bladder cancer risk. We evaluated the association between hair dye use and bladder cancer risk and effect modification by N-acetyltransferase-1 (NAT1), NAT2, glutathione S-transferase Mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) genotypes in a population-based case-control study of 1193 incident cases and 1418 controls from Maine, Vermont and New Hampshire enrolled between 2001 and 2004. Individuals were interviewed in person using a computer-assisted personal interview to assess hair dye use and information on potential confounders and effect modifiers. No overall association between age at first use, year of first use, type of product, color, duration or number of applications of hair dyes and bladder cancer among women or men was apparent, but increased risks were observed in certain subgroups. Women who used permanent dyes and had a college degree, a marker of socioeconomic status, had an increased risk of bladder cancer [odds ratio (OR) = 3.3, 95% confidence interval (CI): 1.2-8.9]. Among these women, we found an increased risk of bladder cancer among exclusive users of permanent hair dyes who had NAT2 slow acetylation phenotype (OR = 7.3, 95% CI: 1.6-32.6) compared to never users of dye with NAT2 rapid/intermediate acetylation phenotype. Although we found no relation between hair dye use and bladder cancer risk in women overall, we detected evidence of associations and gene-environment interaction with permanent hair dye use; however, this was limited to educated women. These results need confirmation with larger numbers, requiring pooling data from multiple studies. JF - International Journal of Cancer AU - Koutros, Stella AU - Silverman, Debra T AU - Baris, Dalsu AU - Zahm, Shelia Hoar AU - Morton, Lindsay M AU - Colt, Joanne S AU - Hein, David W AU - Moore, Lee E AU - Johnson, Alison AU - Schwenn, Molly AU - Cherala, Sai AU - Schned, Alan AU - Doll, Mark A AU - Rothman, Nathaniel AU - Karagas, Margaret R AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, koutross@mail.nih.gov Y1 - 2011/12/15/ PY - 2011 DA - 2011 Dec 15 SP - 2894 EP - 2904 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 12 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Amines KW - Cancer KW - Dyes KW - Enzymes KW - Hair KW - Metabolism KW - Socioeconomics KW - Urinary bladder KW - urinary bladder KW - USA, New England KW - USA, New Hampshire KW - USA, Maine KW - USA, Vermont KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Hair+dye+use+and+risk+of+bladder+cancer+in+the+New+England+bladder+cancer+study&rft.au=Koutros%2C+Stella%3BSilverman%2C+Debra+T%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+Hoar%3BMorton%2C+Lindsay+M%3BColt%2C+Joanne+S%3BHein%2C+David+W%3BMoore%2C+Lee+E%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BCherala%2C+Sai%3BSchned%2C+Alan%3BDoll%2C+Mark+A%3BRothman%2C+Nathaniel%3BKaragas%2C+Margaret+R&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2011-12-15&rft.volume=129&rft.issue=12&rft.spage=2894&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.26245 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.26245/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - urinary bladder; Age; Dyes; Urinary bladder; Socioeconomics; Enzymes; Amines; Hair; Metabolism; Cancer; USA, New England; USA, Maine; USA, New Hampshire; USA, Vermont DO - http://dx.doi.org/10.1002/ijc.26245 ER - TY - CPAPER T1 - The Entire Primary Sequence of Factor VIII Is Synthesized As Two Polypeptide Chains in Hemophilia A Patients with the Intron-22-Inversion T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1313028661; 6121946 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Pandey, Gouri AU - Garfield, Susan AU - Curran, Joanne AU - Moses, Eric AU - Kimchi-Sarfaty, Chava AU - Yanover, Chen AU - Howard, Tom AU - Sauna, Zuben Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - hemophilia KW - Coagulation factors KW - Hemophilia KW - Polypeptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313028661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=The+Entire+Primary+Sequence+of+Factor+VIII+Is+Synthesized+As+Two+Polypeptide+Chains+in+Hemophilia+A+Patients+with+the+Intron-22-Inversion&rft.au=Pandey%2C+Gouri%3BGarfield%2C+Susan%3BCurran%2C+Joanne%3BMoses%2C+Eric%3BKimchi-Sarfaty%2C+Chava%3BYanover%2C+Chen%3BHoward%2C+Tom%3BSauna%2C+Zuben&rft.aulast=Pandey&rft.aufirst=Gouri&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Expression of the Light Chain of Coagulation Factor VIII in Insect Cells T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312998808; 6123212 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Shestopal, Svetlana AU - Kurasawa, James AU - Lee, Timothy AU - Sarafanov, Andrey Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Coagulation KW - Insects KW - Light chains KW - Insect cells KW - Coagulation factor VIII KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Expression+of+the+Light+Chain+of+Coagulation+Factor+VIII+in+Insect+Cells&rft.au=Shestopal%2C+Svetlana%3BKurasawa%2C+James%3BLee%2C+Timothy%3BSarafanov%2C+Andrey&rft.aulast=Shestopal&rft.aufirst=Svetlana&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Single and Codon-Optimized Synonymous Mutations in Factor IX Alter Protein Properties T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312988025; 6080720 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Tseng, Sandra AU - Katagiri, Nobuko AU - Simhadri, Vijaya AU - Jha, Sujata AU - Edwards, Nathan AU - Kopelman, David AU - Sauna, Zuben AU - Stern, Michael AU - Zichel, Michael AU - Komar, Anton AU - Kimchi-Sarfaty, Chava Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Mutation KW - Coagulation factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Single+and+Codon-Optimized+Synonymous+Mutations+in+Factor+IX+Alter+Protein+Properties&rft.au=Tseng%2C+Sandra%3BKatagiri%2C+Nobuko%3BSimhadri%2C+Vijaya%3BJha%2C+Sujata%3BEdwards%2C+Nathan%3BKopelman%2C+David%3BSauna%2C+Zuben%3BStern%2C+Michael%3BZichel%2C+Michael%3BKomar%2C+Anton%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Tseng&rft.aufirst=Sandra&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Temperature Cycling Improves In Vivo recovery of Cold Stored Human Platelets T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312952840; 6083418 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Xu, Fei AU - Gelderman-Fuhrmann, Monique AU - Farrell, John AU - Vostal, Jaroslav Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Temperature effects KW - Platelets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312952840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Temperature+Cycling+Improves+In+Vivo+recovery+of+Cold+Stored+Human+Platelets&rft.au=Xu%2C+Fei%3BGelderman-Fuhrmann%2C+Monique%3BFarrell%2C+John%3BVostal%2C+Jaroslav&rft.aulast=Xu&rft.aufirst=Fei&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles AN - 912924599; 16137696 AB - One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the quality of polyclonal anti-E1E2 antibody responses in immunized mice and chimpanzees was assessed at the level of epitope recognition using peptide scanning and neutralization of chimeric 1a/2a, 1b/2a and 2a HCVcc after blocking or affinity elution of specific antibodies. Mice and chimpanzees were immunized with genotype 1a (H77) HCV gpE1E2; all samples contained cross-neutralizing antibody against HCVcc. By functionally dissecting the polyclonal immune responses we identified three new regions important for neutralization within E1 (aa264-318) and E2 (aa448-483 and aa496-515) of the HCV glycoproteins, the third of which (aa496-515) is highly conserved (85-95%) amongst genotypes. Antibodies to aa496-515 were isolated by affinity binding and elution from the serum of a vaccinated chimpanzee and found to specifically neutralize chimeric 1a/2a, 1b/2a and 2a HCVcc. IC50 titres (IgG ng/mL) for the aa496-515 eluate were calculated as 142.1, 239.37 and 487.62 against 1a/2a, 1b/2a and 2a HCVcc, respectively. Further analysis demonstrated that although antibody to this new, conserved neutralization epitope is efficiently induced with recombinant proteins in mice and chimpanzees; it is poorly induced during natural infection in patients and chimpanzees (7 out of 68 samples positive) suggesting the epitope is poorly presented to the immune system in the context of the viral particle. These findings have important implications for the development of HCV vaccines and strategies designed to protect against heterologous viruses. The data also suggest that recombinant or synthetic antigens may be more efficient at inducing neutralizing antibodies to certain epitopes and that screening virally infected patients may not be the best approach for finding new cross-reactive epitopes. JF - Vaccine AU - Kachko, Alla AU - Kochneva, Galina AU - Sivolobova, Galina AU - Grazhdantseva, Antonina AU - Lupan, Tatyana AU - Zubkova, Iryna AU - Wells, Frances AU - Merchlinsky, Michael AU - Williams, Ollie AU - Watanabe, Hisayoshi AU - Ivanova, Alla AU - Shvalov, Aleksander AU - Loktev, Valeriy AU - Netesov, Sergei AU - Major, Marian E AD - Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, alla.kachko@fda.hhs.gov Y1 - 2011/12/09/ PY - 2011 DA - 2011 Dec 09 SP - 69 EP - 77 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 30 IS - 1 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Data processing KW - Envelopes KW - Epitopes KW - Genotypes KW - Glycoproteins KW - Immune response KW - Immune system KW - Immunoglobulin G KW - Infection KW - Scanning KW - Vaccines KW - Pan troglodytes KW - Hepatitis C virus KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912924599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=New+neutralizing+antibody+epitopes+in+hepatitis+C+virus+envelope+glycoproteins+are+revealed+by+dissecting+peptide+recognition+profiles&rft.au=Kachko%2C+Alla%3BKochneva%2C+Galina%3BSivolobova%2C+Galina%3BGrazhdantseva%2C+Antonina%3BLupan%2C+Tatyana%3BZubkova%2C+Iryna%3BWells%2C+Frances%3BMerchlinsky%2C+Michael%3BWilliams%2C+Ollie%3BWatanabe%2C+Hisayoshi%3BIvanova%2C+Alla%3BShvalov%2C+Aleksander%3BLoktev%2C+Valeriy%3BNetesov%2C+Sergei%3BMajor%2C+Marian+E&rft.aulast=Kachko&rft.aufirst=Alla&rft.date=2011-12-09&rft.volume=30&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.10.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Envelopes; Data processing; Scanning; Immune system; Immunoglobulin G; Glycoproteins; Genotypes; Immune response; Vaccines; Infection; Epitopes; Hepatitis C virus; Pan troglodytes DO - http://dx.doi.org/10.1016/j.vaccine.2011.10.045 ER - TY - JOUR T1 - GOTTLIEB: PRIORITIZE GENERIC SUPPLEMENTAL APPLICATIONS TO STEM SHORTAGES AN - 913045463 AB - A former FDA, and CMS, adviser told House Oversight subcommittee members that the agency should prioritize all supplemental applications for generic injectable drugs, not just those that are in shortage, to prevent future drug shortages and that generic drug user fees could support this effort. JF - Inside Washington Publishers' Inside CMS AU - Week, FDA Y1 - 2011/12/08/ PY - 2011 DA - 2011 Dec 08 CY - Arlington PB - Inside Washington Publishers VL - 14 IS - 25 KW - Health Facilities And Administration KW - Generic drugs KW - Manufacturing KW - Pharmaceutical industry KW - Prescription drugs KW - Manufacturers KW - Legislators KW - Problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913045463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthmanagement&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Inside+Washington+Publishers%27+Inside+CMS&rft.atitle=GOTTLIEB%3A+PRIORITIZE+GENERIC+SUPPLEMENTAL+APPLICATIONS+TO+STEM+SHORTAGES&rft.au=Week%2C+FDA&rft.aulast=Week&rft.aufirst=FDA&rft.date=2011-12-08&rft.volume=14&rft.issue=25&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Inside+Washington+Publishers%27+Inside+CMS&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Inside Washington Publishers Dec 8, 2011 N1 - Last updated - 2011-12-30 ER - TY - GEN T1 - What Works to Prevent or Reduce Internalizing Problems or Socio-Emotional Difficulties in Adolescents: Lessons from Experimental Evaluations of Social Interventions. Fact Sheet. Publication #2011-34 AN - 964180103; ED528672 AB - Left untreated, internalizing problems, such as a depressive or anxious mood, negative self-perceptions, and emotional distress, can undermine one's ability to succeed in school, live a healthy lifestyle, form and maintain close relationships with others, and, in general, accomplish life goals. When internalizing problems are experienced daily for at least two weeks, a psychiatric disorder--such as a major depressive disorder or a generalized anxiety disorder--may be underlying these problems. Among 13- to 18-year-olds, the lifetime prevalence of anxiety disorders is about 32 percent and the lifetime prevalence of mood disorders is about 14 percent. Among the population of U.S. adolescents aged 12 to 17, about 8 percent (about 2 million) had a major depressive episode (moderate to severe depression lasting at least two weeks) during the past year. Half of all adult lifetime cases of mental disorders emerge by age 14 years. Depression and other mood disorders increase risk for suicide, which is the third leading cause of death among U.S. adolescents aged 15 to 19. Overall, the cost of mental health problems has been estimated at about 2.5 percent of our Gross National Product, with $73.4 billion (1997 dollars) spent solely on the treatment of mental illness. This synthesis presents lessons learned from 37 random-assignment social intervention programs for adolescents that are designed to prevent or treat internalizing problems. Programs were identified by searching LINKS (Lifecourse Interventions to Nurture Kids Successfully), Child Trends' online database of rigorously-evaluated social interventions for children and youth. All interventions included in LINKS are social interventions evaluated using random assignment, intent-to-treat evaluations. Note that although this synthesis reviews treatment approaches, it does not review biomedical studies as these studies are not included in LINKS. Findings from this literature review suggest that social interventions to address internalizing problems are most effective when they teach adolescents how to cope with negative thoughts and emotions, solve problems, and interact effectively with others. Therapeutic approaches, such as family therapy, group therapy, individual therapy, and treatment-focused, school-based approaches appear to be effective. Mixed results were found for programs including activities to increase self-esteem and programs directed at non-clinical populations of youth. Among a handful of studies reviewed, programs with a mentoring component and programs targeting only females, although found to improve certain outcomes, were not found to ameliorate internalizing symptoms. (Contains 1 table, 10 footnotes, and 14 endnotes.) [This paper is a product of a co-partnership with the National Adolescent Health Information and Innovation Center (NAHIIC) at the University of California, San Francisco. Additional funding was provided by the Alexander and Margaret Stewart Trust Foundation.] AU - Terzian, Mary AU - Hamilton, Katie AU - Ericson, Sara Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 11 PB - Child Trends. 4301 Connecticut Avenue NW Suite 350, Washington, DC 20008. KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Depression (Psychology) KW - Individual Counseling KW - Intervention KW - Suicide KW - Problem Solving KW - Emotional Disturbances KW - Family Counseling KW - Self Esteem KW - Anxiety Disorders KW - Coping KW - Shyness KW - Posttraumatic Stress Disorder KW - Adolescents KW - Group Counseling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964180103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeric&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=What+Works+to+Prevent+or+Reduce+Internalizing+Problems+or+Socio-Emotional+Difficulties+in+Adolescents%3A+Lessons+from+Experimental+Evaluations+of+Social+Interventions.+Fact+Sheet.+Publication+%232011-34&rft.au=Terzian%2C+Mary%3BHamilton%2C+Katie%3BEricson%2C+Sara&rft.aulast=Terzian&rft.aufirst=Mary&rft.date=2011-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Evaluating the Dilution of Wastewater Treatment Plant Effluent and Viral Impacts on Shellfish Growing Areas in Mobile Bay, Alabama AN - 954659543; 16386765 AB - The U.S. Food and Drug Administration (FDA) provides guidance to state shellfish control authorities on establishing prohibitive closure zones in proximity to wastewater treatment plant (WWTP) discharges with the purpose of minimizing the exposure of molluscan shellfish to health hazards posed by bacterial and viral pathogens present in wastewater effluents. For more than 25 years, the FDA has recognized conditional area management as an option to minimize the size of a prohibitive closure zone, and to enlarge the size and productivity of shellfish growing areas. To use this option, the FDA has recommended achieving a 1,000:1 dilution of effluent within the perimeter of the prohibited closure zone. Using newly available analytical methods and hydrographic equipment, the FDA is undertaking studies to determine whether its 1,000:1 dilution recommendation is supported by the findings. From 2007 through 2009, the FDA conducted field investigations to assess the impacts of wastewater effluent from a large municipal WWTP that discharges into Alabama's Mobile Bay. The dilution of the effluent in the bay was ascertained by conducting a hydrographic dye study using rhodamine WT tracer dye. Submersible fluorometers fastened to oyster cages at sentinel stations were used to determine continuously the dilution of the dye-tagged effluent throughout a 4-day study period. In addition, dilution and dispersion of the dye-tagged effluent was tracked throughout Mobile Bay by fluorometric measurements made while conducting boat transects. The microbiological impacts of the wastewater on molluscan shellfish were assessed by testing oysters placed in cages at sentinel stations at various distances along the anticipated path of the effluent. Levels of fecal coliforms, Escherichia coli, male-specific coliphage, and norovirus genogroups I and II were determined. Norovirus genogroup II was detected in oysters that were located as far as 5.74 km from the discharge, an area in close proximity to the calculated 1,000:1 dilution line. Results also showed that the levels of indicator microorganisms and viral pathogens in the shellfish inversely correlated with increased dilutions of the wastewater effluent in Mobile Bay. JF - Journal of Shellfish Research AU - Goblick, Gregory N AU - Anbarchian, Julie Mayer AU - Woods, Jacquelina AU - Burkhardt, William AU - Calci, Kevin AD - Office of Food Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-325, College Park, MD 20740, gregory.goblick@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 979 EP - 987 PB - National Shellfisheries Association VL - 30 IS - 3 SN - 0730-8000, 0730-8000 KW - Environment Abstracts; Virology & AIDS Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts KW - wastewater KW - shellfish KW - growing area KW - treatment plant KW - Submersibles KW - ASW, USA, Alabama, Mobile Bay KW - Wastewater treatment KW - Public health KW - Sewage disposal KW - Tracers KW - Boats KW - Escherichia coli KW - Mollusca KW - Marine KW - Fecal coliforms KW - Shellfish culture KW - Norovirus KW - Pathogens KW - Food plants KW - Effluents KW - Cages KW - Oysters KW - FDA KW - Wastewater discharges KW - Microorganisms KW - Marine molluscs KW - Shellfish KW - Waste water KW - rhodamine KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - V 22410:Animal Diseases KW - ENA 12:Oceans & Estuaries KW - Q3 08588:Effects of Aquaculture on the Environment KW - Q1 08588:Effects of Aquaculture on the Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954659543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=Evaluating+the+Dilution+of+Wastewater+Treatment+Plant+Effluent+and+Viral+Impacts+on+Shellfish+Growing+Areas+in+Mobile+Bay%2C+Alabama&rft.au=Goblick%2C+Gregory+N%3BAnbarchian%2C+Julie+Mayer%3BWoods%2C+Jacquelina%3BBurkhardt%2C+William%3BCalci%2C+Kevin&rft.aulast=Goblick&rft.aufirst=Gregory&rft.date=2011-12-01&rft.volume=30&rft.issue=3&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/10.2983%2F035.030.0341 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 29 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Sewage disposal; Shellfish culture; Submersibles; Marine molluscs; Pathogens; Effluents; Wastewater treatment; Cages; Public health; Tracers; Fecal coliforms; Boats; Microorganisms; Food plants; Waste water; rhodamine; Oysters; Wastewater discharges; FDA; Shellfish; Escherichia coli; Norovirus; Mollusca; ASW, USA, Alabama, Mobile Bay; Marine DO - http://dx.doi.org/10.2983/035.030.0341 ER - TY - JOUR T1 - Socioeconomic deprivation impact on meat intake and mortality: NIH-AARP Diet and Health Study AN - 926896815; 16333538 AB - Objective: Previous studies have not examined potential interactions between meat intake and characteristics of the local environment on the risk of mortality. This study examined the impact of area socioeconomic deprivation on the association between meat intake and all-cause and cause-specific mortality after accounting for individual-level risk factors. Methods: In the prospective NIH-AARP Diet and Health Study, we analyzed data from adults, ages 50-71 years at baseline (1995-1996). Individual-level dietary intake and health risk information were linked to the demographic and socioeconomic context of participants' local environment based on census tract data. Deaths (n = 33,831) were identified through December 2005. Multilevel Cox models were used to estimate hazard ratios and 95% confidence intervals for quintiles of area deprivation scores. Results: Associations of red and processed meats with mortality were consistent across deprivation quintiles. Men residing in least-deprived neighborhoods had a stronger protective effect for white meat consumption. No differences by deprivation index were observed for women. Conclusion: Red and processed meat intake increases mortality risk regardless of level of deprivation within a given neighborhood suggesting biological mechanisms rather than neighborhood contextual factors may underlie these meat-mortality associations. The effect of white meat intake on cancer mortality was modified by area deprivation among men. JF - Cancer Causes & Control AU - Major, Jacqueline M AU - Cross, Amanda J AU - Doubeni, Chyke A AU - Park, Yikyung AU - Lian, Min AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Graubard, Barry I AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD, 20852, USA, Jacqueline.major@nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1699 EP - 1707 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Census KW - Demography KW - Diets KW - Meat KW - Mortality KW - Risk assessment KW - Risk factors KW - Socioeconomics KW - census KW - demography KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926896815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Socioeconomic+deprivation+impact+on+meat+intake+and+mortality%3A+NIH-AARP+Diet+and+Health+Study&rft.au=Major%2C+Jacqueline+M%3BCross%2C+Amanda+J%3BDoubeni%2C+Chyke+A%3BPark%2C+Yikyung%3BLian%2C+Min%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BGraubard%2C+Barry+I%3BSinha%2C+Rashmi&rft.aulast=Major&rft.aufirst=Jacqueline&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1699&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9846-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Demography; Meat; demography; Risk assessment; census; Diets; Mortality; Risk factors; meat; Socioeconomics; Census; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9846-0 ER - TY - JOUR T1 - Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability AN - 926892337; 16401653 AB - This report examined blood-brain barrier (BBB) related proinflammatory mediators and permeability changes in response to various sized gold nanoparticles (Au-NPs) (3, 5, 7, 10, 30 and 60 nm) in vitro using primary rat brain microvessel endothelial cells (rBMEC). The Au-NPs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and laser Doppler velocimetry (LDV). The accumulation of Au-NPs was determined spectrophotometrically. The rBMEC cytotoxicity of Au-NPs was evaluated by cell proliferation assay (XTT) (concentration range 0.24-15.63 mu g/cm super(2), for 24 h). The time-dependent changes (0, 2, 4 and 8 h) of several proinflammatory mediators (IL-1 beta , IL-2, TNF alpha and PGE sub(2)) were evaluated by ELISA. The smaller Au-NPs (3-7 nm) showed higher rBMEC accumulation compared to larger Au-NPs (10-60 nm), while only moderate decreased cell viability was observed with small Au-NPs (3 nm) at high concentrations ( greater than or equal to 7.8 mu g/cm super(2)). Even though slight changes in cell viability were observed with small Au-NPs, the basal levels of the various proinflammatory mediators remained unchanged with all treatments except LPS (positive control). rBMEC morphology appeared unaffected 24 h after exposure to Au-NPs with only mild changes in fluorescein permeability indicating BBB integrity was unaltered. Together, these data suggest the responses of the cerebral microvasculature to Au-NPs have a significant relationship with the Au-NPs unique size-dependent physiochemical properties. JF - Nanotoxicology AU - Trickler, W J AU - Lantz, S M AU - Murdock, R C AU - Schrand, A M AU - Robinson, B L AU - Newport, G D AU - Schlager, J J AU - Oldenburg, S J AU - Paule, M G AU - Slikker, W Jr AU - Hussain, S M AU - Ali, S F AD - Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, syed.ali@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 479 EP - 492 VL - 5 IS - 4 SN - 1743-5390, 1743-5390 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Blood-brain barrier KW - Inflammation KW - X:24390 KW - N3:11007 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Brain+microvessel+endothelial+cells+responses+to+gold+nanoparticles%3A+In+vitro+pro-inflammatory+mediators+and+permeability&rft.au=Trickler%2C+W+J%3BLantz%2C+S+M%3BMurdock%2C+R+C%3BSchrand%2C+A+M%3BRobinson%2C+B+L%3BNewport%2C+G+D%3BSchlager%2C+J+J%3BOldenburg%2C+S+J%3BPaule%2C+M+G%3BSlikker%2C+W+Jr%3BHussain%2C+S+M%3BAli%2C+S+F&rft.aulast=Trickler&rft.aufirst=W&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.540356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Inflammation DO - http://dx.doi.org/10.3109/17435390.2010.540356 ER - TY - JOUR T1 - Gold nanoparticle trafficking of typically excluded compounds across the cell membrane in JB6 CI 41-5a cells causes assay interference AN - 926892332; 16401652 AB - Nanoparticles (NP) often interfere with the mechanism and interpretation of high throughput in vitro toxicity assays. This interference may occur at any time during the assay and spans most NP systems. This study reports on a specific type of gold NP assay interference, where unmodified gold NPs were able to traffic certain assay molecules that contained primary amines across the cell membrane resulting in false positive results for toxicity assays. The enhanced assay molecule permeability was eliminated when the gold NP surface was both sterically and chemically blocked by polyethylene glycol (PEG). The results support the growing consensus that appropriate controls and assay validation should occur prior to interpretation of results of assays using NP. JF - Nanotoxicology AU - Keene, A M AU - Allaway, R J AU - Sadrieh, N AU - Tyner, K M AD - Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, katherine.tyner@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 469 EP - 478 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN United Kingdom VL - 5 IS - 4 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Permeability KW - amines KW - Cell membranes KW - Gold KW - Toxicity KW - Polyethylene glycol KW - nanoparticles KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Gold+nanoparticle+trafficking+of+typically+excluded+compounds+across+the+cell+membrane+in+JB6+CI+41-5a+cells+causes+assay+interference&rft.au=Keene%2C+A+M%3BAllaway%2C+R+J%3BSadrieh%2C+N%3BTyner%2C+K+M&rft.aulast=Keene&rft.aufirst=A&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.533792 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Permeability; amines; Cell membranes; Gold; Toxicity; nanoparticles; Polyethylene glycol DO - http://dx.doi.org/10.3109/17435390.2010.533792 ER - TY - JOUR T1 - Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study AN - 926892048; 16333537 AB - Objective: Given the large racial differences in prostate cancer risk, further investigation of diet and prostate cancer is warranted among high-risk groups. The purpose of this study was to examine the association between type of meat intake and prostate cancer risk among African-American men. Methods: In the large, prospective NIH-AARP Diet and Health Study, we analyzed baseline (1995-1996) data from African-American participants, aged 50-71 years. Incident prostate cancer cases (n = 1,089) were identified through 2006. Dietary and risk factor data were ascertained by questionnaires administered at baseline. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) within intake quantiles. Results: Neither white nor processed meat intake was associated with prostate cancer, regardless of meat-cooking method. Red meats cooked at high temperatures were associated with an increased risk of prostate cancer (HR = 1.18, 95% CI = 1.00-1.38 and HR = 1.22, 95% CI = 1.03-1.44, for the upper two intake tertiles). Intake of the heterocyclic amine (HCA), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline (DiMeIQx) was positively associated with prostate cancer (HR = 1.30; 95% CI = 1.05-1.61, p = 0.02). No associations were observed for intake of other HCAs. Conclusion: Red meats cooked at high temperatures were positively associated with prostate cancer risk among African-American men. Further studies are needed to replicate these findings. JF - Cancer Causes & Control AU - Major, Jacqueline M AU - Cross, Amanda J AU - Watters, Joanne L AU - Hollenbeck, Albert R AU - Graubard, Barry I AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD, 20852, USA, jacqueline.major@nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1691 EP - 1698 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Diets KW - Meat KW - Risk factors KW - High temperature KW - meat KW - prostate cancer KW - Amines KW - Ethnic groups KW - Cancer KW - high temperature KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Patterns+of+meat+intake+and+risk+of+prostate+cancer+among+African-Americans+in+a+large+prospective+study&rft.au=Major%2C+Jacqueline+M%3BCross%2C+Amanda+J%3BWatters%2C+Joanne+L%3BHollenbeck%2C+Albert+R%3BGraubard%2C+Barry+I%3BSinha%2C+Rashmi&rft.aulast=Major&rft.aufirst=Jacqueline&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1691&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9845-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Meat; Diets; High temperature; Risk factors; meat; Amines; prostate cancer; high temperature; Cancer; Ethnic groups DO - http://dx.doi.org/10.1007/s10552-011-9845-1 ER - TY - JOUR T1 - Impact of hysterectomy and bilateral oophorectomy prevalence on rates of cervical, uterine, and ovarian cancer among American Indian and Alaska Native women, 1999-2004 AN - 926892044; 16333536 AB - Objective: To present more accurate incidence rates of cervical, uterine, and ovarian cancer by geographic region in American Indian/Alaska Native (AI/AN) women. Methods: The authors used data from central cancer registries linked to Indian Health Service (IHS) patient registration database, the Behavioral Risk Factor Surveillance System, IHS National Data Warehouse, and the National Hospital Discharge Survey. Cancer incidence rates were adjusted for hysterectomy and oophorectomy prevalence and presented by region for non-Hispanic White (NHW) and AI/AN women. Results: AI/AN women had a higher prevalence of hysterectomy (23.1%) compared with NHW women (20.9%). Correcting cancer rates for population-at-risk significantly increased the cancer incidence rates among AI/AN women: 43% for cervical cancer, 67% for uterine cancer, and 37% for ovarian cancer. Risk-correction led to increased differences in cervical cancer incidence between AI/AN and NHW women in certain regions. Conclusions: Current reporting of cervical, uterine, and ovarian cancer underestimates the incidence in women at risk and can affect the measure of cancer disparities. Improved cancer surveillance using methodology to correct for population-at-risk may better inform disease control priorities for AI/AN populations. JF - Cancer Causes & Control AU - Wong, Charlene A AU - Jim, Melissa A AU - King, Jessica AU - Tom-Orme, Lillian AU - Henderson, Jeffrey A AU - Saraiya, Mona AU - Richardson, Lisa C AU - Layne, Larry AU - Suryaprasad, Anil AU - Espey, David K AD - Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers of Disease Control and Prevention, Atlanta, GA, USA, david.espey@ihs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1681 EP - 1689 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Disease control KW - Ethnic groups KW - Females KW - Hospitals KW - Ovarian carcinoma KW - Risk factors KW - disease control KW - ovarian carcinoma KW - INE, USA, Alaska KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Impact+of+hysterectomy+and+bilateral+oophorectomy+prevalence+on+rates+of+cervical%2C+uterine%2C+and+ovarian+cancer+among+American+Indian+and+Alaska+Native+women%2C+1999-2004&rft.au=Wong%2C+Charlene+A%3BJim%2C+Melissa+A%3BKing%2C+Jessica%3BTom-Orme%2C+Lillian%3BHenderson%2C+Jeffrey+A%3BSaraiya%2C+Mona%3BRichardson%2C+Lisa+C%3BLayne%2C+Larry%3BSuryaprasad%2C+Anil%3BEspey%2C+David+K&rft.aulast=Wong&rft.aufirst=Charlene&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1681&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9844-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Risk factors; ovarian carcinoma; Disease control; Ovarian carcinoma; Females; disease control; Ethnic groups; Cancer; Hospitals; INE, USA, Alaska DO - http://dx.doi.org/10.1007/s10552-011-9844-2 ER - TY - BOOK T1 - Injuries, Illnesses & Fatalities in Wholesale and Retail Trade in 2005: A Chartbook AN - 925721488; 2011-205640 AB - This Chartbook provides a summary of fatal and nonfatal injury/illness information describing a large population of understudied workplaces and workers: the wholesale and retail trade (WRT) sector. The WRT sector consists of one of ten industry sectors formed from stakeholder meetings conducted throughout the U.S. by NIOSH that served to define the structure of the second decade of NORA. The contents of the WRT Chartbook are based on data from the mid-decade year of 2005. This year was chosen to serve as the baseline for the WRT sector, which corresponds to the launch of the second decade of NORA. The purpose of this Chartbook is to identify high-risk subsectors, as well as industries, occupations, and tasks, in the WRT sector for 2005. Researchers and practitioners will be able to use the Chartbook as a resource to address the controls and prevention needed for reducing the workplace injuries/illnesses and fatalities occurring in the WRT sector. The primary information source for the WRT Chartbook is the U.S. Bureau of Labor Statistics (BLS), which incorporates additional data from the Current Population Survey (CPS) provided by the U.S. Census Bureau, among other related sources [BLS 2010]. The BLS provides through its Web site an extensive set of files containing information on the number and rates of occupational injuries, illnesses, and fatalities. The WRT Chartbook can serve to alert employers, employees, and researchers to hazards in the WRT sector that may affect them, and provide direction for new research and prevention efforts in the sector. The data are presented as tables and charts. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Dec 2011, 146 pp. AU - National Inst Occupational Safety and Health Y1 - 2011/12// PY - 2011 DA - December 2011 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Social conditions and policy - Public safety and security KW - Science and technology policy - Biology and biotechnology KW - Business and service sector - Retail business KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Business and service sector - Business operations, practices, and workplaces KW - Retail trade KW - Death KW - Personal injuries KW - Workplaces KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925721488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2011-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Injuries%2C+Illnesses+%26+Fatalities+in+Wholesale+and+Retail+Trade+in+2005%3A+A+Chartbook&rft.title=Injuries%2C+Illnesses+%26+Fatalities+in+Wholesale+and+Retail+Trade+in+2005%3A+A+Chartbook&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2012-106/pdfs/2012-106.pdf LA - English DB - PAIS Index N1 - Date revised - 2012-03-01 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2011 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Estimation of variant Creutzfeldt-Jakob disease infectivity titers in human blood AN - 920790061; 16162309 AB - BACKGROUND: Blood of individuals with variant Creutzfeldt-Jakob disease (vCJD) is infectious but the titer is unknown. Current estimates of possible vCJD infectivity titers in blood have largely relied on an assumption that the titers of vCJD agent in human blood are likely to be similar to those in blood of rodents infected with model transmissible spongiform encephalopathy agents, assayed by intracerebral inoculations of rodents of the same species. STUDY DESIGN AND METHODS: We analyzed published descriptions of experimental transfusion-transmitted (TT) bovine spongiform encephalopathy and scrapie in sheep and reports of TTvCJD in humans, applying statistical approaches to estimate the probable number of intravenous infectious doses (IDiv) per unit of transfused blood (IDiv/unit). For humans, IDiv/unit of nonleukoreduced red blood cells (NLR-RBCs) were estimated by two statistical models. RESULTS: Sheep blood collected at or near onset of clinical illness contained a mean of 0.80IDiv/unit. Estimates of infectivity in NLR-RBCs from donors incubating vCJD indicated a probable mean infectivity of 0.29IDiv/unit (Model1) and 0.75IDiv/unit (Model2). The analysis predicted a mean of 21 vCJD-infected recipients expected in a cohort transfused with vCJD-implicated NLR-RBCs in the United Kingdom. CONCLUSION: Our analysis suggested that, while less than one IDiv is likely to be present in a given unit of NLR-RBCs collected from a donor incubating vCJD, there is a high probability of TT infection among recipients of vCJD-implicated blood components. The analysis supports continuing measures currently recommended to reduce the risk of TTvCJD. JF - Transfusion AU - Gregori, Luisa AU - Yang, Hong AU - Anderson, Steven AD - From the Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Rockville, Maryland; and the Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 2596 EP - 2602 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 12 SN - 0041-1132, 0041-1132 KW - CSA Neurosciences Abstracts; Virology & AIDS Abstracts; Risk Abstracts KW - Bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - sheep KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920790061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Estimation+of+variant+Creutzfeldt-Jakob+disease+infectivity+titers+in+human+blood&rft.au=Gregori%2C+Luisa%3BYang%2C+Hong%3BAnderson%2C+Steven&rft.aulast=Gregori&rft.aufirst=Luisa&rft.date=2011-12-01&rft.volume=51&rft.issue=12&rft.spage=2596&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2011.03199.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Creutzfeldt-Jakob disease; sheep DO - http://dx.doi.org/10.1111/j.1537-2995.2011.03199.x ER - TY - JOUR T1 - Cell Sources for Bone Regeneration: The Good, the Bad, and the Ugly (But Promising) AN - 915493426; 16153214 AB - Based on the extensive investigation of various ways to regenerate bone, bone marrow stromal cells, in conjunction with ceramic scaffolds, show great promise for application in human patients, and are already in use in a limited number of clinical trials. In preparing for clinical trials, scale-up current good manufacturing processes (cGMP) must incorporate the use of appropriate assays to ensure that the resulting cell product has maintained its biological activity. Future developments are needed to identify better scaffolds, and better ways to deliver cells with either injectable carriers, or by developing techniques to aide in their escape from the circulation and their incorporation into the pre-existing tissue. Lastly, development of methods that faithfully direct pluripotent stem cell differentiation into populations of osteogenic precursors (and ideally, containing skeletal stem cells) represents a new challenge in the field of bone regeneration, but also offer new opportunities to not only to study the biology of bone formation, but also to develop a robust cell source for bone regeneration. JF - Tissue Engineering, Part B: Reviews AU - Robey, P G AD - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, 30 Convent Drive MSC 4320, Building 30, Room 228, Bethesda, MD 20892, USA, probey@dir.nidcr.nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 423 EP - 430 VL - 17 IS - 6 SN - 1937-3368, 1937-3368 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - stromal cells KW - Bone marrow KW - Bone growth KW - Tissue engineering KW - Clinical trials KW - scaffolds KW - Ceramics KW - Cyclic GMP KW - Differentiation KW - Stem cells KW - Reviews KW - Regeneration KW - Osteoprogenitor cells KW - Osteogenesis KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915493426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.atitle=Cell+Sources+for+Bone+Regeneration%3A+The+Good%2C+the+Bad%2C+and+the+Ugly+%28But+Promising%29&rft.au=Robey%2C+P+G&rft.aulast=Robey&rft.aufirst=P&rft.date=2011-12-01&rft.volume=17&rft.issue=6&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.issn=19373368&rft_id=info:doi/10.1089%2Ften.teb.2011.0199 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - stromal cells; Bone growth; Bone marrow; Tissue engineering; Clinical trials; scaffolds; Cyclic GMP; Ceramics; Differentiation; Stem cells; Reviews; Regeneration; Osteoprogenitor cells; Osteogenesis DO - http://dx.doi.org/10.1089/ten.teb.2011.0199 ER - TY - JOUR T1 - Group Medical Claims as a Source of Information on Worker Health and Potentially Work-Related Diseases AN - 915490387; 16152701 AB - Objective: To help address underrecognition of occupational illnesses and support planning of workplace health initiatives. Methods: Data from High-mark Inc., a health care insurer headquartered in Pittsburgh and Camp Hill, Pennsylvania, was used to calculate age and gender-adjusted rates of 15 diseases by industry and broad industry sector. Results: Significant industry differences in disease rates were observed, some corresponding to known differences in workplace risk factors. Conclusion: Group medical claims offer timely, relatively low cost, longitudinal data on rates of physician-diagnosed cases and costs of many diseases for large populations. Limitations of medical claims data include inaccuracies in industry coding, lack of occupation codes, and lack of key variables that affect health. Yet, some elevated industry rates suggest potential new targets for weltaess programs and evaluation of possible workplace health risks. JF - Journal of Occupational and Environmental Medicine AU - Bushnell, P T AU - Li, J AU - Landen, D AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R17, Cincinnati, OH 45226, USA, PLB4@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1430 EP - 1441 VL - 53 IS - 12 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Health care KW - Risk assessment KW - Risk factors KW - hills KW - USA, Pennsylvania KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915490387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Group+Medical+Claims+as+a+Source+of+Information+on+Worker+Health+and+Potentially+Work-Related+Diseases&rft.au=Bushnell%2C+P+T%3BLi%2C+J%3BLanden%2C+D&rft.aulast=Bushnell&rft.aufirst=P&rft.date=2011-12-01&rft.volume=53&rft.issue=12&rft.spage=1430&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3182363bbe LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Risk assessment; hills; Age; Health care; Risk factors; USA, Pennsylvania DO - http://dx.doi.org/10.1097/JOM.0b013e3182363bbe ER - TY - JOUR T1 - The Effect Of Diabetes On Female Labor Force Decisions: New Evidence From The National Health Interview Survey AN - 914790752; 201200600 AB - This paper estimates the effect of diabetes on labor-force participation, hours worked, days-out-of-work due to illness, and earnings using data from the National Health Interview Survey. Findings indicate that diabetes, estimated wholly, is significantly detrimental to most labor market outcomes. However, separation of type I and II diabetes shows that much of the negative effect is due to type II diabetes. On average a female with type II diabetes can experience a wage penalty of almost 50% relative to a healthy individual. Additionally, estimates of specifically type II diabetes may be subject to endogeneity bias. To account for this, I utilize whether an individual's biological mother has been diagnosed with diabetes as an instrumental variable. This instrument provides both theoretical and statistical explanatory power to separate the causal effect of type II diabetes on labor-force decisions. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Minor, Travis AD - FDA/CFSAN, CPK1 HFS-020, 5100 Paint Branch Parkway, College Park, MD 20910, USA Travis.Minor@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 1468 EP - 1486 PB - John Wiley, Chichester UK VL - 20 IS - 12 SN - 1057-9230, 1057-9230 KW - diabetes, labor supply, wages, instrumental variables KW - Type 2 diabetes mellitus KW - Labour market KW - Wages KW - Health KW - Earnings KW - Diabetes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=The+Effect+Of+Diabetes+On+Female+Labor+Force+Decisions%3A+New+Evidence+From+The+National+Health+Interview+Survey&rft.au=Minor%2C+Travis&rft.aulast=Minor&rft.aufirst=Travis&rft.date=2011-12-01&rft.volume=20&rft.issue=12&rft.spage=1468&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1685 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Diabetes; Type 2 diabetes mellitus; Health; Earnings; Wages; Labour market DO - http://dx.doi.org/10.1002/hec.1685 ER - TY - JOUR T1 - A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat AN - 911158909; 16094903 AB - Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify important characteristics of Imb-induced cardiac alterations. Male spontaneously hypertensive rats (SHRs) received oral doses of 10, 30, or 50 mg/kg Imb or water daily for 10 d. Cardiac lesions, detected at all doses, were characterized by cytoplasmic vacuolization and myofibrillar loss. In a second experiment, cardiac lesions were found in Sprague Dawley (SD) and SHR rats given 50 or 100 mg/kg Imb for 14 d. Mean cardiac lesion scores and serum levels of cardiac troponin I were higher in SHRs than in SD rats. Imb induced myocyte death by necrosis, autophagy, and apoptosis. Dose-related increases in cardiac expression were observed for several genes associated with endoplasmic reticulum stress response, protein folding, and vascular development and remodeling. Imb caused alterations in isolated myocytes (myofibrillar loss, highly disrupted and disorganized sarcomeric alpha -actinin, apoptosis, and increased lactate dehydrogenase release) at low concentrations (5 mM). The authors conclude that Imb exerts cardiotoxic effects that are manifest through a complex pattern of cellular alterations, the severity of which can be influenced by arterial blood pressure. JF - Toxicologic Pathology AU - Herman, Eugene H AU - Knapton, Alan AU - Rosen, Elliot AU - Thompson, Karol AU - Rosenzweig, Barry AU - Estis, Joel AU - Agee, Sara AU - Lu, Quynh-Anh AU - Todd, John A AU - Lipshultz, Steven AU - Hasinoff, Brian AU - Zhang, Jun AD - Food and Drug Administration, Division of Applied Pharmacology Research, Silver Spring, Maryland, USA  , eugene.herman@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1091 EP - 1106 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Heart KW - Myocytes KW - Apoptosis KW - Actinin KW - Stress KW - Toxicity KW - Blood pressure KW - L-Lactate dehydrogenase KW - Imatinib KW - Serum levels KW - Endoplasmic reticulum KW - Necrosis KW - Protein folding KW - Troponin I KW - Phagocytosis KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911158909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=A+Multifaceted+Evaluation+of+Imatinib-induced+Cardiotoxicity+in+the+Rat&rft.au=Herman%2C+Eugene+H%3BKnapton%2C+Alan%3BRosen%2C+Elliot%3BThompson%2C+Karol%3BRosenzweig%2C+Barry%3BEstis%2C+Joel%3BAgee%2C+Sara%3BLu%2C+Quynh-Anh%3BTodd%2C+John+A%3BLipshultz%2C+Steven%3BHasinoff%2C+Brian%3BZhang%2C+Jun&rft.aulast=Herman&rft.aufirst=Eugene&rft.date=2011-12-01&rft.volume=39&rft.issue=7&rft.spage=1091&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311419524 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Myocytes; Apoptosis; Actinin; Stress; Toxicity; Blood pressure; L-Lactate dehydrogenase; Serum levels; Imatinib; Endoplasmic reticulum; Necrosis; Protein folding; Phagocytosis; Troponin I; Side effects DO - http://dx.doi.org/10.1177/0192623311419524 ER - TY - JOUR T1 - Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. AN - 907035160; 22087542 AB - A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. The differential gene expression profile induced by silica correlated with its toxicity in the A549 cells. The biological processes perturbed by silica exposure in the A549 cells and rat lungs, as identified by the bioinformatics analysis of the differentially expressed genes, demonstrated significant similarity. Functional categorization of the differentially expressed genes identified cancer, cellular movement, cellular growth and proliferation, cell death, inflammatory response, cell cycle, cellular development, and genetic disorder as top ranking biological functions perturbed by silica exposure in A549 cells and rat lungs. Results of our study, in addition to confirming several previously identified molecular targets and mechanisms involved in silica toxicity, identified novel molecular targets and mechanisms potentially involved in silica-induced pulmonary toxicity. Further investigations, including those focused on the novel molecular targets and mechanisms identified in the current study may result in better management and, possibly, reduction and/or prevention of the potential adverse health effects associated with crystalline silica exposure. JF - Inhalation toxicology AU - Sellamuthu, Rajendran AU - Umbright, Christina AU - Li, Shengqiao AU - Kashon, Michael AU - Joseph, Pius AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 927 EP - 937 VL - 23 IS - 14 KW - Quartz KW - 14808-60-7 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Inbred F344 KW - Cell Survival -- drug effects KW - Humans KW - Microarray Analysis KW - Cell Line, Tumor KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Lung -- drug effects KW - Gene Expression Regulation -- drug effects KW - Lung -- metabolism KW - Quartz -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907035160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Mechanisms+of+crystalline+silica-induced+pulmonary+toxicity+revealed+by+global+gene+expression+profiling.&rft.au=Sellamuthu%2C+Rajendran%3BUmbright%2C+Christina%3BLi%2C+Shengqiao%3BKashon%2C+Michael%3BJoseph%2C+Pius&rft.aulast=Sellamuthu&rft.aufirst=Rajendran&rft.date=2011-12-01&rft.volume=23&rft.issue=14&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2011.625995 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-13 N1 - Date created - 2011-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/08958378.2011.625995 ER - TY - JOUR T1 - Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. AN - 905676027; 21908763 AB - Kava is a plant traditionally used for making beverages in Pacific Basin countries and has been used for the treatment of nervous disorders in the United States. The pharmacological activity of kava is achieved through kavalactones in kava extract, which include kawain, 7,8-dihydrokawain, yangonin, 5,6-dehydrokawain, methysticin, and 7,8-dihydromethysticin. Recent studies have shown that kava extract induces hepatic CYP1A1 enzyme; however, the mechanisms of CYP1A1 induction have not been elucidated, and the kavalactones responsible for CYP1A1 induction have not yet been identified. Using a combination of biochemical assays and molecular docking tools, we determined the functions of kava extract and kavalactones and delineated the underlying mechanisms involved in CYP1A1 induction. The results showed that kava extract displayed a concentration-dependent effect on CYP1A1 induction. Among the six major kavalactones, methysticin triggered the most profound inducing effect on CYP1A1 followed by 7,8-dihydromethysticin. The other four kavalactones (yangonin, 5,6-dehydrokawain, kawain, and 7,8-dihydrokawain) did not show significant effects on CYP1A1. Consistent with the experimental results, in silico molecular docking studies based on the aryl hydrocarbon receptor (AhR)-ligand binding domain homology model also revealed favorable binding to AhR for methysticin and 7,8-dihydromethysticin compared with the remaining kavalactones. Additionally, results from a luciferase gene reporter assay suggested that kava extract, methysticin, and 7,8-dihydromethysticin were able to activate the AhR signaling pathway. Moreover, kava extract-, methysticin-, and 7,8-dihydromethysticin-mediated CYP1A1 induction was blocked by an AhR antagonist and abolished in AhR-deficient cells. These findings suggest that kava extract induces the expression of CYP1A1 via an AhR-dependent mechanism and that methysticin and 7,8-dihydromethysticin contribute to CYP1A1 induction. The induction of CYP1A1 indicates a potential interaction between kava or kavalactones and CYP1A1-mediated chemical carcinogenesis. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Li, Yan AU - Mei, Hu AU - Wu, Qiangen AU - Zhang, Suhui AU - Fang, Jia-Long AU - Shi, Leming AU - Guo, Lei AD - Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 388 EP - 399 VL - 124 IS - 2 KW - 7,8-dihydromethysticin KW - 0 KW - Lactones KW - Ligands KW - Plant Extracts KW - Pyrans KW - Pyrones KW - Receptors, Aryl Hydrocarbon KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - methysticin KW - M832AIJ6HX KW - Index Medicus KW - Gene Expression -- drug effects KW - Molecular Structure KW - Animals KW - Dose-Response Relationship, Drug KW - Models, Molecular KW - Cell Line, Tumor KW - Mice KW - Protein Binding KW - Binding Sites KW - Cell Survival -- drug effects KW - Transfection KW - Receptors, Aryl Hydrocarbon -- agonists KW - Enzyme Induction KW - Receptors, Aryl Hydrocarbon -- genetics KW - Pyrones -- pharmacology KW - Pyrans -- pharmacology KW - Lactones -- isolation & purification KW - Cytochrome P-450 CYP1A1 -- genetics KW - Pyrans -- isolation & purification KW - Pyrones -- isolation & purification KW - Kava -- chemistry KW - Plant Extracts -- chemistry KW - Cytochrome P-450 CYP1A1 -- biosynthesis KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905676027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Methysticin+and+7%2C8-dihydromethysticin+are+two+major+kavalactones+in+kava+extract+to+induce+CYP1A1.&rft.au=Li%2C+Yan%3BMei%2C+Hu%3BWu%2C+Qiangen%3BZhang%2C+Suhui%3BFang%2C+Jia-Long%3BShi%2C+Leming%3BGuo%2C+Lei&rft.aulast=Li&rft.aufirst=Yan&rft.date=2011-12-01&rft.volume=124&rft.issue=2&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr235 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-16 N1 - Date created - 2011-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr235 ER - TY - JOUR T1 - Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States. AN - 904014674; 21947397 AB - Resistance to extended-spectrum cephalosporins (ESC) among members of the family Enterobacteriaceae occurs worldwide; however, little is known about ESC resistance in Escherichia coli strains from companion animals. Clinical isolates of E. coli were collected from veterinary diagnostic laboratories throughout the United States from 2008 to 2009. E. coli isolates (n = 54) with reduced susceptibility to ceftazidime or cefotaxime (MIC ≥ 16 μg/ml) and extended-spectrum-β-lactamase (ESBL) phenotypes were analyzed. PCR and sequencing were used to detect mutations in ESBL-encoding genes and the regulatory region of the chromosomal gene ampC. Conjugation experiments and plasmid identification were conducted to examine the transferability of resistance to ESCs. All isolates carried the bla(CTX-M-1)-group β-lactamase genes in addition to one or more of the following β-lactamase genes: bla(TEM), bla(SHV-3), bla(CMY-2), bla(CTX-M-14-like), and bla(OXA-1.) Different bla(TEM) sequence variants were detected in some isolates (n = 40). Three isolates harbored a bla(TEM-181) gene with a novel mutation resulting in an Ala184Val substitution. Approximately 78% of the isolates had mutations in promoter/attenuator regions of the chromosomal gene ampC, one of which was a novel insertion of adenine between bases -28 and -29. Plasmids ranging in size from 11 to 233 kbp were detected in the isolates, with a common plasmid size of 93 kbp identified in 60% of isolates. Plasmid-mediated transfer of β-lactamase genes increased the MICs (≥ 16-fold) of ESCs for transconjugants. Replicon typing among isolates revealed the predominance of IncI and IncFIA plasmids, followed by IncFIB plasmids. This study shows the emergence of conjugative plasmid-borne ESBLs among E. coli strains from companion animals in the United States, which may compromise the effective therapeutic use of ESCs in veterinary medicine. JF - Antimicrobial agents and chemotherapy AU - Shaheen, Bashar W AU - Nayak, Rajesh AU - Foley, Steven L AU - Kweon, Ohgew AU - Deck, Joanna AU - Park, Miseon AU - Rafii, Fatemeh AU - Boothe, Dawn M AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA. bashar.shaheen@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 5666 EP - 5675 VL - 55 IS - 12 KW - Anti-Bacterial Agents KW - 0 KW - Cephalosporins KW - Escherichia coli Proteins KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Plasmids -- genetics KW - Conjugation, Genetic KW - Cat Diseases -- microbiology KW - beta-Lactamases -- genetics KW - beta-Lactamases -- chemistry KW - Cats KW - Dog Diseases -- microbiology KW - Dogs KW - Electrophoresis, Gel, Pulsed-Field KW - United States -- epidemiology KW - Microbial Sensitivity Tests KW - beta-Lactamases -- metabolism KW - Escherichia coli Proteins -- genetics KW - Pets KW - Escherichia coli Infections -- microbiology KW - Cephalosporins -- pharmacology KW - Cephalosporin Resistance -- genetics KW - Escherichia coli Infections -- veterinary KW - Escherichia coli -- isolation & purification KW - Escherichia coli Infections -- epidemiology KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904014674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Molecular+characterization+of+resistance+to+extended-spectrum+cephalosporins+in+clinical+Escherichia+coli+isolates+from+companion+animals+in+the+United+States.&rft.au=Shaheen%2C+Bashar+W%3BNayak%2C+Rajesh%3BFoley%2C+Steven+L%3BKweon%2C+Ohgew%3BDeck%2C+Joanna%3BPark%2C+Miseon%3BRafii%2C+Fatemeh%3BBoothe%2C+Dawn+M&rft.aulast=Shaheen&rft.aufirst=Bashar&rft.date=2011-12-01&rft.volume=55&rft.issue=12&rft.spage=5666&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00656-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-29 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2000 Sep;44(9):2534-6 [10952609] Vet Microbiol. 2010 Aug 26;144(3-4):363-70 [20233641] Antimicrob Agents Chemother. 2001 Oct;45(10):2716-22 [11557460] Clin Microbiol Rev. 2001 Oct;14(4):933-51, table of contents [11585791] Antimicrob Agents Chemother. 2001 Dec;45(12):3647-50 [11709361] Vet Microbiol. 2002 Jan 3;84(1-2):143-53 [11731167] J Antimicrob Chemother. 2002 Jan;49(1):77-85 [11751770] J Am Vet Med Assoc. 2002 Jan 15;220(2):190-2 [12126128] Antimicrob Agents Chemother. 2002 Oct;46(10):3156-63 [12234838] J Clin Microbiol. 2002 Oct;40(10):3586-95 [12354850] Antimicrob Agents Chemother. 2002 Dec;46(12):3991-4 [12435708] FEMS Microbiol Lett. 2003 Mar 28;220(2):177-80 [12670678] Vet Microbiol. 2003 Jun 24;94(1):57-69 [12742716] Antimicrob Agents Chemother. 2004 Jan;48(1):1-14 [14693512] Microb Drug Resist. 2004 Spring;10(1):1-9 [15140388] Antimicrob Agents Chemother. 2004 Jun;48(6):2308-13 [15155242] Antimicrob Agents Chemother. 2004 Aug;48(8):2845-52 [15273090] J Antimicrob Chemother. 2004 Aug;54(2):321-32 [15254022] Clin Microbiol Rev. 1995 Oct;8(4):557-84 [8665470] Antimicrob Agents Chemother. 1995 Dec;39(12):2593-601 [8592985] Biophys J. 1998 Jul;75(1):422-7 [9649402] J Antimicrob Chemother. 1999 Apr;43(4):447-58 [10350372] Antimicrob Agents Chemother. 2005 Jan;49(1):358-65 [15616316] J Antimicrob Chemother. 2000 Jun;45(6):783-8 [10837430] Antimicrob Agents Chemother. 2005 Feb;49(2):833-5 [15673782] Antimicrob Agents Chemother. 2005 Mar;49(3):1262-4 [15728945] Emerg Infect Dis. 2005 Sep;11(9):1464-6 [16229784] Antimicrob Agents Chemother. 2005 Nov;49(11):4745-50 [16251320] J Microbiol Methods. 2005 Dec;63(3):219-28 [15935499] J Antimicrob Chemother. 2005 Dec;56(6):1107-10 [16239288] Infect Control Hosp Epidemiol. 2006 Mar;27(3):312-4 [16532423] Antimicrob Agents Chemother. 2006 Sep;50(9):3203-6 [16940132] Antimicrob Agents Chemother. 2006 Sep;50(9):3220-1 [16940136] J Antimicrob Chemother. 2006 Dec;58(6):1311-2 [17023496] Vet Microbiol. 2007 Apr 15;121(3-4):197-214 [17306475] FEMS Microbiol Lett. 2007 May;270(2):265-71 [17326753] Vet Microbiol. 2008 Feb 5;127(1-2):97-105 [17870255] J Antimicrob Chemother. 2008 Feb;61(2):273-81 [18077311] J Clin Microbiol. 2008 Mar;46(3):1110-2 [18184851] Vet Microbiol. 2008 May 25;129(1-2):203-8 [18166282] Antimicrob Agents Chemother. 2009 Jan;53(1):327-8 [19001117] Antimicrob Agents Chemother. 2009 Feb;53(2):519-24 [18936192] J Antimicrob Chemother. 2009 Oct;64(4):723-30 [19638354] J Antimicrob Chemother. 2009 Dec;64(6):1181-6 [19815633] J Clin Microbiol. 2010 Mar;48(3):883-8 [20032253] J Antimicrob Chemother. 2010 Apr;65(4):651-60 [20118165] J Vet Intern Med. 2010 Mar-Apr;24(2):323-30 [20102505] Antimicrob Agents Chemother. 2010 Aug;54(8):3489-92 [20479196] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):283-8 [11114163] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AAC.00656-11 ER - TY - JOUR T1 - Reduced aldehyde dehydrogenase activity and arginine vasopressin receptor 2 expression in the kidneys of male TALLYHO/JngJ mice of prediabetic age. AN - 903149132; 21879339 AB - The TALLYHO/JngJ (TH) mouse is a novel polygenic model of type 2 diabetes and exhibits obesity, hyperglycemia (males), hyperinsulinemia, hyperlipidemia, and enlarged pancreatic islets. Since the kidney is damaged by hyperglycemia in other animal models, the present study aimed to determine the kidney phenotype of TH mice using immunoblot and histological analyses of the kidneys of 6-week-old (prediabetic) and 16-week-old TH mice. Interestingly, even 6-week-old male TH mice showed significant increases in kidney weight, compared to C57BL/B6 (B6) mice. Cuboidal parietal epithelium was observed in the Bowman's capsule in male TH mice at the prediabetic age. Water accumulated inside the kidneys of male TH mice in an age-dependent manner, but not in B6 mice. Since Swr/J mice are reported to develop diabetes insipidus and share 86.8% genotype homology with TH mice, the expression level of arginine vasopressin receptor 2 (AVPR2), a candidate protein for diabetes insipidus, was examined and determined to be significantly reduced in the kidneys of prediabetic male TH mice, compared to B6 mice. Aldehyde dehydrogenase (ALDH) activity in the kidneys of prediabetic male TH mice was significantly lower than that in age-matched male B6 mice, while there were no differences between female TH and B6 mice. These results suggest that the kidney phenotype of prediabetic TH mice occurs only in males, accompanied by a reduction in ALDH activity and AVPR2 expression. The kidney phenotype of male TH mice at a prediabetic age becomes evident before the onset of diabetes. JF - Endocrine AU - Nakamura, Noriko AD - Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Noriko.Nakamura@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 379 EP - 385 VL - 40 IS - 3 KW - Receptors, Vasopressin KW - 0 KW - Arginine Vasopressin KW - 113-79-1 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Index Medicus KW - Bowman Capsule -- anatomy & histology KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Sex Factors KW - Mice, Inbred C57BL KW - Case-Control Studies KW - Disease Models, Animal KW - Mice KW - Water-Electrolyte Balance KW - Organ Size KW - Male KW - Female KW - Matched-Pair Analysis KW - Receptors, Vasopressin -- metabolism KW - Kidney -- metabolism KW - Diabetes Mellitus, Type 2 -- metabolism KW - Diabetes Mellitus, Type 2 -- physiopathology KW - Aldehyde Dehydrogenase -- metabolism KW - Kidney -- physiopathology KW - Kidney -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/903149132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine&rft.atitle=Reduced+aldehyde+dehydrogenase+activity+and+arginine+vasopressin+receptor+2+expression+in+the+kidneys+of+male+TALLYHO%2FJngJ+mice+of+prediabetic+age.&rft.au=Nakamura%2C+Noriko&rft.aulast=Nakamura&rft.aufirst=Noriko&rft.date=2011-12-01&rft.volume=40&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Endocrine&rft.issn=1559-0100&rft_id=info:doi/10.1007%2Fs12020-011-9528-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-26 N1 - Date created - 2011-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12020-011-9528-4 ER - TY - JOUR T1 - Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity. AN - 902331814; 21281223 AB - The goal was to determine if increasing welding voltage changes the physico-chemical properties of the fume and influences lung responses. Rats inhaled 40 mg/m³ (3 h/day × 3 days) of stainless steel (SS) welding fume generated at a standard voltage setting of 25 V (regular SS) or at a higher voltage (high voltage SS) of 30 V. Particle morphology, size and composition were characterized. Bronchoalveolar lavage was performed at different times after exposures to assess lung injury. Fumes collected from either of the welding conditions appeared as chain-like agglomerates of nanometer-sized primary particles. High voltage SS welding produced a greater number of ultrafine-sized particles. Fume generated by high voltage SS welding was higher in manganese. Pulmonary toxicity was more substantial and persisted longer after exposure to the regular SS fume. In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile. JF - Nanotoxicology AU - Antonini, James M AU - Keane, Michael AU - Chen, Bean T AU - Stone, Samuel AU - Roberts, Jenny R AU - Schwegler-Berry, Diane AU - Andrews, Ronnee N AU - Frazer, David G AU - Sriram, Krishnan AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. jga6@cdc.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 700 EP - 710 VL - 5 IS - 4 KW - Air Pollutants, Occupational KW - 0 KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Particle Size KW - Inhalation Exposure KW - Male KW - Microscopy, Electron, Scanning KW - Welding -- methods KW - Stainless Steel -- toxicity KW - Lung -- cytology KW - Lung -- chemistry KW - Lung -- drug effects KW - Air Pollutants, Occupational -- toxicity KW - Stainless Steel -- chemistry KW - Nanoparticles -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902331814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Alterations+in+welding+process+voltage+affect+the+generation+of+ultrafine+particles%2C+fume+composition%2C+and+pulmonary+toxicity.&rft.au=Antonini%2C+James+M%3BKeane%2C+Michael%3BChen%2C+Bean+T%3BStone%2C+Samuel%3BRoberts%2C+Jenny+R%3BSchwegler-Berry%2C+Diane%3BAndrews%2C+Ronnee+N%3BFrazer%2C+David+G%3BSriram%2C+Krishnan&rft.aulast=Antonini&rft.aufirst=James&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.550695 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-30 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.550695 ER - TY - JOUR T1 - Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments. AN - 902331808; 21261457 AB - Measurement of the surface area of airborne nanoparticles as administered to an experimental subject is critical for characterizing exposures during inhalation experiments. A filter-based surface area measurement methodology is described herein that allows for such determinations. Krypton gas adsorption was used to determine total particle surface area. Track-etched polycarbonate 0.4 μm pore filters were chosen as the collection substrate for metal oxide particles due to their highly reproducible surface areas and low background weights. The subject nanomaterials included two different batches of ultrafine TiO₂, TiO₂ nanorods, and SiO₂. The instrument detection limit for surface area was 200 cm² (0.02 m²). Ninety percent confidence interval estimates of method accuracy were 17.7-23.5% with a point estimate of 20.8%. The filter-based surface area measurement strategy is demonstrated to be a viable sampling and analysis methodology that provides much needed physical characterization information of particles as administered in an animal inhalation chamber. JF - Nanotoxicology AU - LeBuf, Ryan F AU - Stefaniak, Aleksandr B AU - Chen, Bean T AU - Frazer, David G AU - Virji, M Abbas AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. rlebouf@cdc.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 687 EP - 699 VL - 5 IS - 4 KW - Aerosols KW - 0 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Microscopy, Electron, Transmission KW - Silicon Dioxide -- analysis KW - Titanium -- chemistry KW - Titanium -- analysis KW - Porosity KW - Linear Models KW - Toxicity Tests KW - Adsorption KW - Silicon Dioxide -- chemistry KW - Inhalation Exposure -- analysis KW - Nanoparticles -- analysis KW - Aerosols -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902331808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Measurement+of+airborne+nanoparticle+surface+area+using+a+filter-based+gas+adsorption+method+for+inhalation+toxicology+experiments.&rft.au=LeBuf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BVirji%2C+M+Abbas&rft.aulast=LeBuf&rft.aufirst=Ryan&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.546951 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-30 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.546951 ER - TY - JOUR T1 - Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells. AN - 902328846; 21826740 AB - The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals treated with genotoxic agents, and that flow cytometry can be used to identify rare RBCs deficient in the GPI-anchored protein, CD59, as a marker of Pig-a gene mutation. We investigated if a similar approach could be used for detecting gene mutation in humans. We first determined the frequency of spontaneous CD59-deficient RBCs (presumed PIG-A mutants) in 97 self-identified healthy volunteers. For most subjects, the frequency of CD59-deficient RBCs was low (average of 5.1 ± 4.9 × 10(-6) ; median of 3.8 × 10(-6) and mutant frequency less than 8 × 10(-6) for 75% of subjects), with a statistically significant difference in median mutant frequencies between males and females. PIG-A RBC mutant frequency displayed poor correlation with the age and no correlation with the smoking status of the subjects. Also, two individuals had markedly increased CD59-deficient RBC frequencies of ∼300 × 10(-6) and ∼100 × 10(-6) . We then monitored PIG-A mutation in 10 newly diagnosed cancer patients undergoing chemotherapy with known genotoxic drugs. The frequency of CD59-deficient RBCs in the blood of the patients was measured before the start of chemotherapy and three times over a period of ∼6 months while on/after chemotherapy. Responses were generally weak, most observations being less than the median mutant frequency for both males and females; the greatest response was an approximate three-fold increase in the frequency of CD59-deficient RBCs in one patient treated with a combination of cisplatin and etoposide. These results suggest that the RBC PIG-A assay can be adopted to measuring somatic cell mutation in humans. Further research is necessary to determine the assay's sensitivity in detecting mutations induced by genotoxic agents acting via different mechanisms. Copyright © 2011 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Dobrovolsky, Vasily N AU - Elespuru, Rosalie K AU - Bigger, C Anita H AU - Robison, Timothy W AU - Heflich, Robert H AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, USA. vasily.dobrovolsky@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 784 EP - 794 VL - 52 IS - 9 KW - Antigens, CD59 KW - 0 KW - Antineoplastic Agents KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - CD59 protein, human KW - 101754-01-2 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Flow Cytometry KW - Adolescent KW - Male KW - Female KW - Antigens, CD59 -- genetics KW - Erythrocytes -- drug effects KW - Genetic Testing -- methods KW - Antineoplastic Agents -- toxicity KW - Mutagens -- toxicity KW - Membrane Proteins -- genetics KW - Erythrocytes -- metabolism KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902328846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Monitoring+humans+for+somatic+mutation+in+the+endogenous+PIG-a+gene+using+red+blood+cells.&rft.au=Dobrovolsky%2C+Vasily+N%3BElespuru%2C+Rosalie+K%3BBigger%2C+C+Anita+H%3BRobison%2C+Timothy+W%3BHeflich%2C+Robert+H&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=784&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20667 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20667 ER - TY - JOUR T1 - Report on stage III Pig-a mutation assays using benzo[a]pyrene. AN - 902328778; 22052432 AB - Genotoxicity assays were conducted on rats treated with benzo[a]pyrene (BaP) as part of Stage III of a validation study on the Pig-a gene mutation assay. Assays were performed at the U.S. FDA-NCTR and Bayer-Germany. Starting on Day 1, groups of five 6- to 7-week-old male Fischer 344 (F344, used at FDA-NCTR) and Han Wistar rats (Bayer) were given 28 daily doses of 0, 37.5, 75, or 150 mg/kg BaP; blood was sampled on Days -1, 4, 15, 29, and 56. Pig-a mutant frequencies were determined on Days -1, 15, 29, and 56 in total red blood cells (RBCs) and reticulocytes (RETs) as RBC(CD59-) and RET(CD59-) frequencies; percent micronucleated-RETs (%MN-RET) were measured on Days 4 and 29. RBC(CD59-) and RET(CD59-) frequencies increased in a dose- and time-dependent manner, producing significant increases by Day 29 in both rat models. The responses for RETs were stronger than those for RBCs, and the responses in F344 rats were stronger than in Han Wistar rats. BaP also produced significant increases in %MN-RET frequency at Days 4 and 29, with the responses being greater in F344 than Han Wistar rats. The overall findings were consistent with those of the reference laboratory using Han Wistar rats. Finally, mutation assays performed on splenocytes from Day 56 F344 rats indicated that BaP mutant frequencies were three to fivefold higher for the Hprt gene than the Pig-a gene. The results indicate that the Pig-a RET and RBC assays are reproducible, transferable, and show promise for integrating gene mutation into 28-day repeat-dose studies. Copyright © 2011 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Bhalli, Javed A AU - Shaddock, Joseph G AU - Pearce, Mason G AU - Dobrovolsky, Vasily N AU - Cao, Xuefei AU - Heflich, Robert H AU - Vohr, Hans-Werner AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 731 EP - 737 VL - 52 IS - 9 KW - Antigens, CD59 KW - 0 KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - Benzo(a)pyrene KW - 3417WMA06D KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Index Medicus KW - Erythrocytes -- drug effects KW - Animals KW - Endpoint Determination KW - Calibration KW - Reticulocytes -- ultrastructure KW - Risk Assessment KW - Erythrocytes -- ultrastructure KW - Rats KW - Reticulocytes -- drug effects KW - International Cooperation KW - Reticulocytes -- metabolism KW - Data Interpretation, Statistical KW - T-Lymphocytes -- drug effects KW - Time Factors KW - Comet Assay -- standards KW - Male KW - Micronucleus Tests -- methods KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Micronucleus Tests -- standards KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Reference Standards KW - Erythrocytes -- metabolism KW - Comet Assay -- methods KW - Laboratories -- standards KW - Antigens, CD59 -- genetics KW - T-Lymphocytes -- ultrastructure KW - Species Specificity KW - Mutagenicity Tests -- methods KW - Benzo(a)pyrene -- toxicity KW - Mutagens -- toxicity KW - Mutagenicity Tests -- standards KW - Membrane Proteins -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902328778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Report+on+stage+III+Pig-a+mutation+assays+using+benzo%5Ba%5Dpyrene.&rft.au=Bhalli%2C+Javed+A%3BShaddock%2C+Joseph+G%3BPearce%2C+Mason+G%3BDobrovolsky%2C+Vasily+N%3BCao%2C+Xuefei%3BHeflich%2C+Robert+H%3BVohr%2C+Hans-Werner&rft.aulast=Bhalli&rft.aufirst=Javed&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20675 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20675 ER - TY - JOUR T1 - Evaluation of false positive rate based on exposure-response analyses for two compounds in fixed-dose combination products AN - 1837304658; 16837051 AB - We explored the type I error rate (false positive rate) associated with exposure-response (ER) analyses for two compounds in a fixed-dose combination product through simulations. In the simulations, at least one compound was assumed to be inactive, whereas the active compound followed E sub(max) model at different concentration ranges. The simulated data were independently evaluated by pre-specified univariate or multivariate linear, log-linear models, and mixed linear log-linear models. The type I error rate was evaluated by comparing the total number of falsely identified significant slope estimates with the total number of models with successful convergence. We demonstrated that ER analyses results based on data from fixed-dose combination products at various dose levels should be interpreted with caution. A univariate analysis, even though is appropriate to guide dose selection, is inadequate to identify the active compound. Multivariate analyses can be applied to determine the active compound only when the underlying ER relationship for each compound (especially for the active compound) has been adequately defined or approximated. The false positive rate in determining a significant ER relationship is elevated, when the underlying ER relationship (especially for the active compound) is erroneously or inadequately defined. Without the assurance of the correct structural models, the identified significant ER relationship does not necessarily indicate that the compound associated with the significant slope estimate is pharmacologically active. JF - Journal of Pharmacokinetics and Biopharmaceutics AU - Zhu, Hao AU - Wang, Yaning AD - Division of Pharmacometrics, Office of Clinical Pharmacology, CDER, FDA, 10903 New Hampshire Avenue, Room 3150, Building 51, Silver Spring, MD, 20993, USA, Hao.Zhu@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 671 EP - 696 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 6 SN - 1567-567X, 1567-567X KW - Toxicology Abstracts KW - Data processing KW - Multivariate analysis KW - Convergence KW - Dose-response effects KW - Pharmacokinetics KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837304658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacokinetics+and+Biopharmaceutics&rft.atitle=Evaluation+of+false+positive+rate+based+on+exposure-response+analyses+for+two+compounds+in+fixed-dose+combination+products&rft.au=Zhu%2C+Hao%3BWang%2C+Yaning&rft.aulast=Zhu&rft.aufirst=Hao&rft.date=2011-12-01&rft.volume=38&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacokinetics+and+Biopharmaceutics&rft.issn=1567567X&rft_id=info:doi/10.1007%2Fs10928-011-9214-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Data processing; Convergence; Multivariate analysis; Dose-response effects; Pharmacokinetics; Models DO - http://dx.doi.org/10.1007/s10928-011-9214-4 ER - TY - JOUR T1 - Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea AN - 1458535162; 16695251 AB - Treating rats with single doses of N-ethyl-N-nitrosourea (ENU) results in a time-dependent accumulation of Pig-a-mutant phenotype peripheral red blood cells (RBCs), reaching a plateau at about 6-weeks posttreatment, with the response persisting for at least 26 weeks. In the present study, groups of 5 C57BL/6 male mice were administered single i.p. doses of up to 140 mg/kg ENU, and blood samples were collected up to 26 weeks posttreatment. The samples were analyzed by flow cytometry for the frequency of CD24-deficient (presumed Pig-a mutant) reticulocytes (RETs) and total RBCs; micronucleated RET frequencies were evaluated at 1 day posttreatment. Mean Pig-a mutant frequencies and micronucleated RET frequencies increased in a dose-responsive manner, with maximum Pig-a frequencies in RETs and RBCs observed at Week 2 and Week 4 posttreatment, respectively. Mutant frequencies in RETs and RBCs generally decreased slowly with time after reaching their maxima. In a second experiment, groups of five male C57BL/6 mice were given single i.p. injections of 8, 32, or 160 mg/kg ENU, or four weekly doses of 8 or 40 mg/kg ENU (split doses totaling 32 and 160 mg/kg, respectively). In each case the maximum RET and RBC mutant frequencies produced by the split doses were similar to but not as great as the mutant frequencies produced by the equivalent single doses. The data indicate that ENU-induced Pig-a mutant RBC frequencies accumulate in mice as they do in rats; however, mice and rats differ in the manifestation kinetics and the persistence of the responses. ? Environ. Mol. Mutagen. 2011. Published 2011 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Bhalli, Javed A AU - Pearce, Mason G AU - Dobrovolsky, Vasily N AU - Heflich, Robert H Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 766 EP - 773 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 9 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts KW - Mutagens KW - Data processing KW - Erythrocytes KW - Mice KW - Mutant frequency KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Kinetics KW - Ethyl nitrosourea KW - Reticulocytes KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458535162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Manifestation+and+persistence+of+Pig-a+mutant+red+blood+cells+in+C57BL%2F6+mice+following+single+and+split+doses+of+N-ethyl-N-nitrosourea&rft.au=Bhalli%2C+Javed+A%3BPearce%2C+Mason+G%3BDobrovolsky%2C+Vasily+N%3BHeflich%2C+Robert+H&rft.aulast=Bhalli&rft.aufirst=Javed&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20682 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20682/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Mutagens; Data processing; Kinetics; Erythrocytes; Ethyl nitrosourea; Mutant frequency; Reticulocytes; Mutagenesis; Rats; Mice; Mutants DO - http://dx.doi.org/10.1002/em.20682 ER - TY - JOUR T1 - Measuring surface area of airborne titanium dioxide powder agglomerates: relationships between gas adsorption, diffusion and mobility-based methods AN - 1439736904; 18524374 AB - Inhalation toxicology studies generally use the Brunauer, Emmett, and Teller (BET) gas adsorption method to measure total surface area of particles whereas occupational exposures are more readily measured by real-time mobility-based surface areas or active surface area measured with diffusion charger-based instruments. Three surface area measurement methods were studied: filter-based inert gas adsorption (BET method), diffusion charging, and mobility-based methods. The goal of the project was to investigate and develop a correlation between the measurement methods. The experimental design consisted of measuring surface area in a series of five trials for each of two powder types, fine and ultrafine titanium dioxide with primary particle sizes of 440 and 20 nm, respectively, and two aerosol concentrations. Diffusion charger instruments tended to underestimate the total particle surface area measured by the BET, but were well correlated with mobility-based surface areas obtained from a scanning mobility particle sizer. Filter-based gas adsorption methods and diffusion charging methods provide different but valuable information on total and active surface areas of particles, respectively. Results indicate they should not be used as predictors of one another. JF - Journal of Nanoparticle Research AU - LeBouf, Ryan F AU - Ku, Bon Ki AU - Chen, Bean T AU - Frazer, David G AU - Cumpston, Jared L AU - Stefaniak, Aleksandr B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, 26505, USA, astefaniak@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 7029 EP - 7039 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 13 IS - 12 SN - 1388-0764, 1388-0764 KW - Health & Safety Science Abstracts KW - Aerosols KW - Titanium dioxide KW - Mobility KW - Surface area KW - Adsorption KW - Diffusion KW - Particulates KW - Measuring instruments KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439736904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanoparticle+Research&rft.atitle=Measuring+surface+area+of+airborne+titanium+dioxide+powder+agglomerates%3A+relationships+between+gas+adsorption%2C+diffusion+and+mobility-based+methods&rft.au=LeBouf%2C+Ryan+F%3BKu%2C+Bon+Ki%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BCumpston%2C+Jared+L%3BStefaniak%2C+Aleksandr+B&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2011-12-01&rft.volume=13&rft.issue=12&rft.spage=7029&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanoparticle+Research&rft.issn=13880764&rft_id=info:doi/10.1007%2Fs11051-011-0616-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Aerosols; Titanium dioxide; Mobility; Surface area; Adsorption; Diffusion; Measuring instruments; Particulates; Occupational exposure DO - http://dx.doi.org/10.1007/s11051-011-0616-4 ER - TY - RPRT T1 - Head Start Children, Families, and Programs: Present and Past Data from FACES. OPRE Report 2011-33a AN - 1314326102; ED539261 AB - This report provides a portrait of children entering Head Start for the first time in fall 2009, as well as of their family backgrounds and the classrooms and programs that serve them. The report also offers comparisons across the past decade of the Head Start program to delineate trends and changes in the population served and the services provided. Data are drawn from the Head Start Family and Child Experiences Survey (FACES), which was first launched in 1997 as a periodic, longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, and opinions; Head Start classroom practices and quality measures; and child and family outcomes. FACES includes a battery of child assessments across many developmental domains; interviews with children's parents, teachers, and program managers; and observations of classroom quality. In 2008, the Administration for Children and Families (ACF) funded Mathematica Policy Research and its partners--Educational Testing Service and Juarez and Associates--to design and conduct FACES 2009. (Contains 18 figures, 4 tables, and 61 notes.) AU - Hulsey, Lara Kristin AU - Aikens, Nikki AU - Kopack, Ashley AU - West, Jerry AU - Moiduddin, Emily AU - Tarullo, Louisa Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 44 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Research Reports KW - Classroom Environment KW - Teacher Attitudes KW - Preschool Tests KW - Credentials KW - Outcomes of Education KW - Classroom Observation Techniques KW - Child Development KW - Administrator Attitudes KW - Population Trends KW - Preschool Children KW - Teacher Qualifications KW - Preschool Evaluation KW - Educational Testing KW - Annual Reports KW - Longitudinal Studies KW - Cohort Analysis KW - Educational Practices KW - Opinions KW - Parent Attitudes KW - Interviews KW - Participant Characteristics KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1314326102?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Phylogenetic Status and Timescale for the Diversification of Steno and Sotalia Dolphins AN - 1311711296 AB - Molecular data have provided many insights into cetacean evolution but some unsettled issues still remain. We estimated the topology and timing of cetacean evolutionary relationships using Bayesian and maximum likelihood analyses of complete mitochondrial genomes. In order to clarify the phylogenetic placement of Sotalia and Steno within the Delphinidae, we sequenced three new delphinid mitogenomes. Our analyses support three delphinid clades: one joining Steno and Sotalia (supporting the revised subfamily Stenoninae); another placing Sousa within the Delphininae; and a third, the Globicephalinae, which includes Globicephala, Feresa, Pseudorca, Peponocephala and Grampus. We also conclude that Orcinus does not belong in the Globicephalinae, but Orcaella may be part of that subfamily. Divergence dates were estimated using the relaxed molecular clock calibrated with fossil data. We hypothesise that the timing of separation of the marine and Amazonian Sotalia species (2.3 Ma) coincided with the establishment of the modern Amazon River basin. JF - PLoS One AU - Cunha, Haydée A AU - Moraes, Lucas C AU - Medeiros, Bruna V AU - Lailson-Brito, José AU - Silva, M Fda AU - Solé-Cava, Antonio M AU - Schrago, Carlos G Y1 - 2011/12// PY - 2011 DA - Dec 2011 CY - San Francisco PB - Public Library of Science VL - 6 IS - 12 KW - Sciences: Comprehensive Works KW - Studies KW - Dolphins & porpoises KW - Evolution KW - Age KW - Genomes KW - Diversification KW - Phylogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1311711296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Phylogenetic+Status+and+Timescale+for+the+Diversification+of+Steno+and+Sotalia+Dolphins%3A+e28297&rft.au=Cunha%2C+Hayd%C3%A9e+A%3BMoraes%2C+Lucas+C%3BMedeiros%2C+Bruna+V%3BLailson-Brito%2C+Jos%C3%A9%3BSilva%2C+M+Fda%3BSol%C3%A9-Cava%2C+Antonio+M%3BSchrago%2C+Carlos+G&rft.aulast=Cunha&rft.aufirst=Hayd%C3%A9e&rft.date=2011-12-01&rft.volume=6&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0028297 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2011 Cunha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cunha HA, Moraes LC, Medeiros BV, Lailson-Brito J Jr, da Silva VMF, et al. (2011) Phylogenetic Status and Timescale for the Diversification of Steno and Sotalia Dolphins. PLoS ONE 6(12): e28297. doi:10.1371/journal.pone.0028297 N1 - Last updated - 2013-02-25 DO - http://dx.doi.org/10.1371/journal.pone.0028297 ER - TY - JOUR T1 - Parenting Practices among Depressed Mothers in the Child Welfare System AN - 1221410286; 201208007 AB - The purpose of this study was to analyze a nationally representative sample of families referred to Child Protective Services (CPS) agencies, the National Survey of Child and Adolescent Well-Being, to examine the association between maternal depression and parenting practices over a 36-month follow-up period. Three hypotheses were tested: (1) Depressed mothers are more likely to demonstrate harsh parenting than are nondepressed mothers; (2) depressed mothers are more likely to demonstrate neglectful parenting than are nondepressed mothers; and (3) depressed mothers are more likely to demonstrate emotional maltreatment than are nondepressed mothers. The interaction between depression and time was also analyzed for each parenting practice to determine how changes in maternal depression affected changes in parenting. The sample for this study was 1,536 mother-child dyads in which the child was age three to 10 years and remained in the home after a CPS investigation. Depression remained high across time points and was associated with increased risk of emotional maltreatment and neglect over a 36-month period. In addition, self-reported emotional maltreatment remained high across time points. Implications of this work are the needs for better identification of mental health needs for mothers entering the child welfare system and parent training to specifically address positive parenting. Adapted from the source document. JF - Social Work Research AU - Kohl, Patricia L AU - Kagotho, Jacqueline Njeri AU - Dixon, David AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Missouri, USA pkohl@gwbmail.wustl.edu Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 215 EP - 225 PB - Association of Social Workers, Washington DC VL - 35 IS - 4 SN - 1070-5309, 1070-5309 KW - child welfare, maternal depression, National Survey of Child and Adolescent Well-Being, parenting KW - Parent Training KW - Depression (Psychology) KW - Well Being KW - Child Welfare Services KW - Mothers KW - Family KW - Childrearing Practices KW - Children KW - Adolescents KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221410286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+Research&rft.atitle=Parenting+Practices+among+Depressed+Mothers+in+the+Child+Welfare+System&rft.au=Kohl%2C+Patricia+L%3BKagotho%2C+Jacqueline+Njeri%3BDixon%2C+David&rft.aulast=Kohl&rft.aufirst=Patricia&rft.date=2011-12-01&rft.volume=35&rft.issue=4&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Social+Work+Research&rft.issn=10705309&rft_id=info:doi/10.1093%2Fswr%2F35.4.215 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mothers; Childrearing Practices; Child Welfare Services; Depression (Psychology); Children; Well Being; Family; Adolescents; Parent Training DO - http://dx.doi.org/10.1093/swr/35.4.215 ER - TY - JOUR T1 - Field evaluation of a new prototype self-contained breathing apparatus AN - 1038283499; 17045454 AB - Firefighters are required to use a self-contained breathing apparatus (SCBA) for respiratory protection when engaged in a variety of firefighting duties. While the SCBA provides crucial respiratory support and protection, it is also cumbersome and heavy, thus adding to the physical work performed by the firefighter. The purpose of the present study was to evaluate and compare the low profile SCBA prototype to a standard SCBA, as assessed by the objective and subjective measures of mobility and comfort, time of donning/doffing, as well as by acquiring user feedback on SCBA design features during field activities. The results of the present study indicated that the prototype SCBA was rated as a significant improvement over the standard SCBA in the areas of range of motion (ROM), mobility, comfort, induction of fatigue, interaction with protective clothing, and operability when worn over a standard firefighter ensemble, while performing a series of International Association of Fire Fighters Fire Ground Survival Program training exercises. Statement of Relevance: A prototype SCBA was evaluated and compared with a standard SCBA, focusing on the objective and subjective measures of mobility and comfort during field activities. Feedback from end users was collected during the evaluation. The findings of the present study can be used for improving the system design and overall performance of new prototype SCBAs. JF - Ergonomics AU - Coca, Aitor AU - Kim, Jung-Hyun AU - Duffy, Richard AU - Williams, WJon AD - CDC/NIOSH/NPPTL, Pittsburgh, PA, USA Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1197 EP - 1206 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 54 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - self-contained breathing apparatus KW - range of motion KW - subjective perceptions KW - firefighters KW - Fires KW - Fatigue KW - firefighter services KW - Mobility KW - Prototypes KW - Survival KW - Ergonomics KW - Working conditions KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038283499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Field+evaluation+of+a+new+prototype+self-contained+breathing+apparatus&rft.au=Coca%2C+Aitor%3BKim%2C+Jung-Hyun%3BDuffy%2C+Richard%3BWilliams%2C+WJon&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2011-12-01&rft.volume=54&rft.issue=12&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2011.622797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fires; Fatigue; Mobility; firefighter services; Prototypes; Survival; Working conditions; Ergonomics; International standardization DO - http://dx.doi.org/10.1080/00140139.2011.622797 ER - TY - JOUR T1 - Thirty years of AIDS in America: a story of infinite hope AN - 1024211222; 4310973 AB - The year 2011 marks the thirtieth anniversary of the first case reports in the United States of what we now know to be end-stage HIV disease. This chronological milestone provides an opportunity to reflect upon the changing context of the American HIV/AIDS epidemic. Using two seminal documents as a framework, the 1986 Institute of Medicine Report, 'Confronting AIDS,' and the 2010 National HIV/AIDS Strategy, this descriptive analysis details our accomplishments in addressing the domestic U.S. epidemic and outlines what remains to be done on the long road to eradication of HIV disease. The past three decades have witnessed tremendous biomedical and behavioral advances in preventing, diagnosing, and treating HIV disease. However, to fully realize the promise of these scientific advances, such that we achieve the vision of the National HIV/AIDS Strategy, we must develop effective strategies to surmount a number of salient challenges, including: unbalanced combinations of prevention interventions; programs that are not of adequate scale to achieve population-level results; systems of service delivery that do not function in an integrated fashion; and social and economic structures that increase the vulnerability of populations who are at risk for or living with HIV disease. Adapted from the source document. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Valdiserri, Ronald O AD - US Department of Health and Human Services Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 479 EP - 494 VL - 23 IS - 6 SN - 0899-9546, 0899-9546 KW - Sociology KW - Prevention KW - Epidemics KW - Economic structure KW - Biomedicine KW - AIDS KW - Medical treatment KW - Diseases KW - U.S.A. KW - HIV KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024211222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Thirty+years+of+AIDS+in+America%3A+a+story+of+infinite+hope&rft.au=Valdiserri%2C+Ronald+O&rft.aulast=Valdiserri&rft.aufirst=Ronald&rft.date=2011-12-01&rft.volume=23&rft.issue=6&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 482 3617 6220; 10072; 1618 7894; 4014; 5703 3617 6220; 3617 6220; 10449 5772; 7890 5792 10484; 4356 3617 6220; 433 293 14 ER - TY - JOUR T1 - Update of the NIOSH life table analysis system: A person-years analysis program for the windows computing environment AN - 1017970867; 16691497 AB - Background Person-years analysis is a fundamental tool of occupational epidemiology. A life table analysis system (LTAS), previously developed by the National Institute for Occupational Safety and Health, was limited by its platform and analysis and reporting capabilities. We describe the updating of LTAS for the Windows operating system (LTAS.NET) with improved properties. Software Development Process A group of epidemiologists, programmers, and statisticians developed software, platform, and computing requirements. Statistical methods include the use of (indirectly) standardized mortality ratios, (directly) standardized rate ratios, confidence intervals, and P values based on the normal approximation and exact Poisson methods, and a trend estimator for linear exposure-response associations. Software Features We show examples using LTAS.NET to stratify and analyze multiple fixed and time-dependent variables. Data import, stratification, and reporting options are highly flexible. Users may export stratified data for Poisson regression modeling. Conclusions LTAS.NET incorporates improvements that will facilitate more complex person-years analysis of occupational cohort data. Am. J. Ind. Med. 54:915-924, 2011. ? 2011 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Schubauer-Berigan, Mary K AU - Hein, Misty J AU - Raudabaugh, William M AU - Ruder, Avima M AU - Silver, Sharon R AU - Spaeth, Steven AU - Steenland, Kyle AU - Petersen, Martin R AU - Waters, Kathleen M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, zcg3@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 915 EP - 924 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 12 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Computer programs KW - Mortality KW - exports KW - Dose-response effects KW - statisticians KW - Occupational safety KW - Standards KW - Stratification KW - imports KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Update+of+the+NIOSH+life+table+analysis+system%3A+A+person-years+analysis+program+for+the+windows+computing+environment&rft.au=Schubauer-Berigan%2C+Mary+K%3BHein%2C+Misty+J%3BRaudabaugh%2C+William+M%3BRuder%2C+Avima+M%3BSilver%2C+Sharon+R%3BSpaeth%2C+Steven%3BSteenland%2C+Kyle%3BPetersen%2C+Martin+R%3BWaters%2C+Kathleen+M&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2011-12-01&rft.volume=54&rft.issue=12&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20999 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20999/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Mortality; Computer programs; exports; statisticians; Dose-response effects; Occupational safety; Standards; Stratification; imports DO - http://dx.doi.org/10.1002/ajim.20999 ER - TY - JOUR T1 - In Utero Exposure to Maternal Tobacco Smoke and Subsequent Obesity, Hypertension, and Gestational Diabetes Among Women in The MoBa Cohort AN - 1660052983; 16537014 AB - Background: Environmental factors influencing the developmental origins of health and disease need to be identified and investigated. In utero exposure to tobacco smoke has been associated with obesity and a small increase in blood pressure in children; however, whether there is a corresponding increased risk of conditions such as diabetes and hypertension during adulthood remains unclear. Objective: Our goal was to assess the association of self-reported in utero exposure to tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of age. Methods: We conducted a cross-sectional analysis of the Norwegian Mother and Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were ascertained from the Medical Birth Registry of Norway and the questionnaire. Our analysis included 74,023 women. Results: Women exposed to tobacco smoke in utero had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] relative to those unexposed, after adjusting for age, education, and personal smoking. After further adjustment for body mass index, the odds ratio for hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed. Conclusions: Exposure to tobacco smoke in utero was associated with obesity, hypertension, and GDM in adult women. The possibility that the associations were attributable to unmeasured confounding cannot be excluded. JF - Environmental Health Perspectives AU - Cupul-Uicab, Lea A AU - Skjaerven, Rolv AU - Haug, Kjell AU - Melve, Kari K AU - Engel, Stephanie M AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/29/ PY - 2011 DA - 2011 Nov 29 SP - 355 EP - 360 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - diabetes mellitus KW - gestational diabetes KW - hypertension KW - in utero KW - maternal smoking KW - MoBa KW - obesity KW - tobacco smoke KW - Smoke KW - Diabetes mellitus KW - Obesity KW - Gestation KW - Tobacco KW - Health KW - Hypertension KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660052983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In+Utero+Exposure+to+Maternal+Tobacco+Smoke+and+Subsequent+Obesity%2C+Hypertension%2C+and+Gestational+Diabetes+Among+Women+in+The+MoBa+Cohort&rft.au=Cupul-Uicab%2C+Lea+A%3BSkjaerven%2C+Rolv%3BHaug%2C+Kjell%3BMelve%2C+Kari+K%3BEngel%2C+Stephanie+M%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2011-11-29&rft.volume=120&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103789 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1103789 ER - TY - JOUR T1 - Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. AN - 906153348; 22001122 AB - Aluminum is a ubiquitous element that is released naturally into the environment via volcanic activity and the breakdown of rocks on the earth's surface. Exposure of the general population to aluminum occurs primarily through the consumption of food, antacids, and buffered analgesics. Exposure to aluminum in the general population can also occur through vaccination, since vaccines often contain aluminum salts (frequently aluminum hydroxide or aluminum phosphate) as adjuvants. Because concerns have been expressed by the public that aluminum in vaccines may pose a risk to infants, we developed an up-to-date analysis of the safety of aluminum adjuvants. Keith et al. [1] previously analyzed the pharmacokinetics of aluminum for infant dietary and vaccine exposures and compared the resulting body burdens to those based on the minimal risk levels (MRLs) established by the Agency for Toxic Substances and Disease Registry. We updated the analysis of Keith et al. [1] with a current pediatric vaccination schedule [2]; baseline aluminum levels at birth; an aluminum retention function that reflects changing glomerular filtration rates in infants; an adjustment for the kinetics of aluminum efflux at the site of injection; contemporaneous MRLs; and the most recent infant body weight data for children 0-60 months of age [3]. Using these updated parameters we found that the body burden of aluminum from vaccines and diet throughout an infant's first year of life is significantly less than the corresponding safe body burden of aluminum modeled using the regulatory MRL. We conclude that episodic exposures to vaccines that contain aluminum adjuvant continue to be extremely low risk to infants and that the benefits of using vaccines containing aluminum adjuvant outweigh any theoretical concerns. Published by Elsevier Ltd. JF - Vaccine AU - Mitkus, Robert J AU - King, David B AU - Hess, Maureen A AU - Forshee, Richard A AU - Walderhaug, Mark O AD - Office of Biostatistics and Epidemiology, USFDA Center for Biologics Evaluation and Research, 1401 Rockville Pike, HFM-210, Rockville, MD 20852, United States. Robert.Mitkus@fda.hhs.gov Y1 - 2011/11/28/ PY - 2011 DA - 2011 Nov 28 SP - 9538 EP - 9543 VL - 29 IS - 51 KW - Adjuvants, Immunologic KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Humans KW - Aluminum -- adverse effects KW - Vaccination -- adverse effects KW - Aluminum -- pharmacokinetics KW - Adjuvants, Immunologic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/906153348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Updated+aluminum+pharmacokinetics+following+infant+exposures+through+diet+and+vaccination.&rft.au=Mitkus%2C+Robert+J%3BKing%2C+David+B%3BHess%2C+Maureen+A%3BForshee%2C+Richard+A%3BWalderhaug%2C+Mark+O&rft.aulast=Mitkus&rft.aufirst=Robert&rft.date=2011-11-28&rft.volume=29&rft.issue=51&rft.spage=9538&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2011.09.124 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-22 N1 - Date created - 2011-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Vaccine. 2002 May 31;20 Suppl 3:S13-7 [12184359] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2011.09.124 ER - TY - CPAPER T1 - Terminology Standardization in CT: Progress and Challenges T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313064019; 6070633 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Mills, Thalia Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Standardization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313064019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Terminology+Standardization+in+CT%3A+Progress+and+Challenges&rft.au=Mills%2C+Thalia&rft.aulast=Mills&rft.aufirst=Thalia&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FDA Dose Reduction Initiative: CT Progress T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313028779; 6069165 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Stern, Stanley Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313028779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=FDA+Dose+Reduction+Initiative%3A+CT+Progress&rft.au=Stern%2C+Stanley&rft.aulast=Stern&rft.aufirst=Stanley&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Overlapping Reconstruction on Lung Nodule Volume Estimation with Multidetector CT T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313016173; 6071162 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Gavrielides, M AU - Zeng, R AU - Sahiner, B AU - Myers, K AU - Petrick, N Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Lung nodules KW - Nodules UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Effect+of+Overlapping+Reconstruction+on+Lung+Nodule+Volume+Estimation+with+Multidetector+CT&rft.au=Gavrielides%2C+M%3BZeng%2C+R%3BSahiner%2C+B%3BMyers%2C+K%3BPetrick%2C+N&rft.aulast=Gavrielides&rft.aufirst=M&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Emerging CAD Applications T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1312999707; 6072217 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Sahiner, Berkman Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Technology KW - Nuclear medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Emerging+CAD+Applications&rft.au=Sahiner%2C+Berkman&rft.aulast=Sahiner&rft.aufirst=Berkman&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Transcriptional activity of DNMT3B in pancreatic cancer cells: effects of -149 (C→T) promoter polymorphism. AN - 905679009; 21854760 AB - Polymorphic C-to-T change in the promoter region of DNA-methyltransferase-3B (DNMT3B) gene is associated with risk of several cancers. The aim of this study was to investigate the effect of DNMT3B promoter genetic variant on its transcriptional activity and to compare activity in several pancreatic cell lines. DNMT3B promoter constructs carrying either -149C allele or -149T allele were transiently transfected into pancreatic cancer cells. In promoter assaying, carriage of -149T allele showed only a slight activity (1.1-fold) in Mia cells (p=0.462). In contrast, significant increase (3.8-fold) in activity of -149T allele was shown in SU86.86 pancreatic cancer cells (p=0.0001). These preliminary findings suggest that genetic variance may influence DNMT3B expression in pancreatic cancer. Further studies are needed. Published by Elsevier Inc. JF - Biochemical and biophysical research communications AU - Xiao, Yongmei AU - Word, Beverly AU - Hammons, George AU - Lyn-Cook, Beverly AD - Office of Regulatory Activities, National Center for Toxicological Research, Jefferson, AR 72079, United States. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 220 EP - 223 VL - 415 IS - 2 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA methyltransferase 3B KW - Index Medicus KW - DNA Methylation KW - Humans KW - Transcription, Genetic KW - Promoter Regions, Genetic -- genetics KW - Cell Line, Tumor KW - Gene Expression Regulation, Neoplastic KW - DNA (Cytosine-5-)-Methyltransferase -- genetics KW - Gene Expression Regulation, Enzymologic KW - Pancreatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905679009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Transcriptional+activity+of+DNMT3B+in+pancreatic+cancer+cells%3A+effects+of+-149+%28C%E2%86%92T%29+promoter+polymorphism.&rft.au=Xiao%2C+Yongmei%3BWord%2C+Beverly%3BHammons%2C+George%3BLyn-Cook%2C+Beverly&rft.aulast=Xiao&rft.aufirst=Yongmei&rft.date=2011-11-18&rft.volume=415&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2011.07.115 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-18 N1 - Date created - 2011-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2011.07.115 ER - TY - JOUR T1 - Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. AN - 904007534; 21884834 AB - Human exposure to nanoparticles is inevitable from natural and anthropogenic sources. Titanium dioxide (TiO2) nanoparticles are increasingly being used in pharmaceutical and cosmetic products. Previous studies revealed that TiO2 levels were significantly increased in tissues (e.g., lymph nodes) after mice were injected with nanosized TiO2. To identify early response lymph node proteins to TiO2 nanoparticles, groups of mice were intradermally injected with a low dose of DeGussa P25 TiO2 nanoparticles or vehicle alone. The proteomes of lymph nodes at 24 h were quantitatively analyzed using trypsin-catalyzed 16O/18O labeling in conjunction with two-dimensional liquid chromatography separation and tandem mass spectrometry (2DLC-MS/MS). A total of 33 proteins were significantly changed (over 1.3-fold, p<0.05) in the mice treated with TiO2 nanoparticles, which accounted for approximately 1% of the total proteins identified. The differentially expressed proteins mainly involve the immune response (e.g., inflammation), lipid and fatty acid metabolism, mRNA processing, and nucleosome assembly. Regulation of functionally distinct classes of proteins could be mediated by estrogen receptor (ESR1), PPARγ, and c-Myc signalings, etc. The differentially expressed proteins identified in this experiment could represent early response proteins to TiO2 nanoparticle treatment in mouse lymph nodes. Published by Elsevier B.V. JF - Journal of proteomics AU - Gao, Yuan AU - Gopee, Neera V AU - Howard, Paul C AU - Yu, Li-Rong AD - Center of Excellence for Proteomics, Division of Systems Biology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 2745 EP - 2759 VL - 74 IS - 12 KW - Biocompatible Materials KW - 0 KW - Proteome KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Female KW - Proteomics -- methods KW - Lymph Nodes -- metabolism KW - Titanium -- administration & dosage KW - Biocompatible Materials -- administration & dosage KW - Gene Expression Regulation -- immunology KW - Proteome -- metabolism KW - Gene Expression Regulation -- drug effects KW - Nanoparticles -- administration & dosage KW - Proteome -- immunology KW - Lymph Nodes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904007534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteomics&rft.atitle=Proteomic+analysis+of+early+response+lymph+node+proteins+in+mice+treated+with+titanium+dioxide+nanoparticles.&rft.au=Gao%2C+Yuan%3BGopee%2C+Neera+V%3BHoward%2C+Paul+C%3BYu%2C+Li-Rong&rft.aulast=Gao&rft.aufirst=Yuan&rft.date=2011-11-18&rft.volume=74&rft.issue=12&rft.spage=2745&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteomics&rft.issn=1876-7737&rft_id=info:doi/10.1016%2Fj.jprot.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-01 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomed Nanotechnol. 2010 Feb;6(1):1-19 [20499827] Curr Opin Biotechnol. 2007 Dec;18(6):565-71 [18160274] Adv Mater. 2010 Jun 25;22(24):2601-27 [20512811] Nat Biotechnol. 2010 Dec;28(12):1300-3 [21057497] Mol Cell Proteomics. 2011 Jan;10(1):M110.003335 [20807836] Arch Toxicol. 2008 Mar;82(3):151-7 [18000654] Eur J Immunol. 2008 May;38(5):1404-13 [18389478] Environ Mol Mutagen. 2008 Jun;49(5):399-405 [18418868] Biochem Biophys Res Commun. 2008 Aug 22;373(2):315-8 [18571499] Nat Nanotechnol. 2007 Aug;2(8):469-78 [18654343] Br J Cancer. 2008 Aug 5;99(3):392-7 [18648371] J Toxicol Sci. 2008 Aug;33(3):293-8 [18670160] Nano Lett. 2008 Sep;8(9):2779-87 [18687009] Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14265-70 [18809927] Genes Dev. 2008 Nov 1;22(21):2953-67 [18981474] J Hazard Mater. 2009 Feb 15;162(1):57-65 [18554790] J Proteome Res. 2009 May;8(5):2140-3 [19338309] Mol Cell Proteomics. 2009 May;8(5):1130-49 [19181660] J Proteome Res. 2009 May;8(5):2157-63 [19222237] Toxicol Sci. 2009 Sep;111(1):37-48 [19574408] Cancer Res. 2009 Nov 15;69(22):8784-9 [19887611] Environ Sci Pollut Res Int. 2010 Mar;17(3):798-806 [19390888] Nanotechnology. 2010 Mar 26;21(12):125105 [20203358] Toxicol Sci. 2010 May;115(1):156-66 [20156837] Toxicol Lett. 2010 Jun 2;195(2-3):161-8 [20381595] Int J Pharm. 2000 Mar 10;196(2):245-9 [10699728] J Biol Chem. 2001 Oct 12;276(41):37731-4 [11459852] Rapid Commun Mass Spectrom. 2001;15(24):2456-65 [11746917] Electrophoresis. 2002 Jan;23(2):356-62 [11840544] Nat Biotechnol. 2004 Jan;22(1):93-7 [14661026] Proteomics. 2004 Mar;4(3):753-65 [14997497] Eur J Immunol. 1992 Jul;22(7):1891-7 [1378023] Electrophoresis. 1996 May;17(5):945-53 [8783021] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11509-10 [9751695] Biochim Biophys Acta. 1998 Dec 10;1448(2):200-11 [9920411] J Proteome Res. 2005 Mar-Apr;4(2):523-31 [15822930] Environ Health Perspect. 2005 Jul;113(7):823-39 [16002369] Toxicol Sci. 2006 May;91(1):227-36 [16495353] Proteomics. 2006 Jul;6(13):3833-44 [16767787] EMBO J. 2006 Oct 18;25(20):4854-64 [17024186] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Nature. 2006 Nov 16;444(7117):267-9 [17108940] Rapid Commun Mass Spectrom. 2006;20(23):3491-7 [17072904] Curr Opin Biotechnol. 2006 Dec;17(6):562-8 [17015011] Proteomics. 2007 Jan;7(2):220-31 [17163576] Toxicology. 2007 Jan 25;230(1):90-104 [17196727] Biochem Biophys Res Commun. 2007 May 18;356(4):942-7 [17395154] Toxicol Sci. 2007 Jul;98(1):249-57 [17404394] Nat Biotechnol. 2007 Oct;25(10):1159-64 [17873867] N Engl J Med. 2007 Oct 11;357(15):1469-72 [17928593] J Proteome Res. 2007 Nov;6(11):4150-62 [17924679] ACS Nano. 2010 Jun 22;4(6):3363-73 [20481555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jprot.2011.08.009 ER - TY - JOUR T1 - Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans AN - 911168516; 16076121 AB - A physiologically based pharmacokinetic (PBPK) model was developed for bisphenol A (BPA) in adult rhesus monkeys using intravenous (iv) and oral bolus doses of 100 mu gd6-BPA/kg (). This calibrated PBPK adult monkey model for BPA was then evaluated against published monkey kinetic studies with BPA. Using two versions of the adult monkey model based on monkey BPA kinetic data from and , the aglycone BPA pharmacokinetics were simulated for human oral ingestion of 5mg d16-BPA per person (Volkel et al., 2002). Volkel et al. were unable to detect the aglycone BPA in plasma, but were able to detect BPA metabolites. These human model predictions of the aglycone BPA in plasma were then compared to previously published PBPK model predictions obtained by simulating the Volkel et al. kinetic study. Our BPA human model, using two parameter sets reflecting two adult monkey studies, both predicted lower aglycone levels in human serum than the previous human BPA PBPK model predictions. BPA was metabolized at all ages of monkey (PND 5 to adult) by the gut wall and liver. However, the hepatic metabolism of BPA and systemic clearance of its phase II metabolites appear to be slower in younger monkeys than adults. The use of the current non-human primate BPA model parameters provides more confidence in predicting the aglycone BPA in serum levels in humans after oral ingestion of BPA. JF - Toxicology and Applied Pharmacology AU - Fisher, Jeffrey W AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Doerge, Daniel R AD - Food & Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology , 3900 NCTR Road, Jefferson, AR 72079, USA, jeffrey.fisher@fda.hhs.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 122 EP - 136 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 257 IS - 1 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Metabolites KW - Bisphenol A KW - Macaca mulatta KW - bisphenol A KW - Aglycones KW - Intravenous administration KW - Data processing KW - Dosimetry KW - Ingestion KW - Primates KW - Pharmacokinetics KW - Serum levels KW - Digestive tract KW - Kinetics KW - Liver KW - Metabolism KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetic+modeling%3A+Prediction+and+evaluation+of+route+dependent+dosimetry+of+bisphenol+A+in+monkeys+with+extrapolation+to+humans&rft.au=Fisher%2C+Jeffrey+W%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Fisher&rft.aufirst=Jeffrey&rft.date=2011-11-15&rft.volume=257&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.08.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Serum levels; Bisphenol A; Age; Intravenous administration; Aglycones; Data processing; Digestive tract; Kinetics; Dosimetry; Liver; Metabolites; Pharmacokinetics; bisphenol A; Ingestion; Metabolism; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.taap.2011.08.026 ER - TY - JOUR T1 - A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models. AN - 902340963; 22013118 AB - Optimum efficacy of therapeutic cancer vaccines may require combinations that generate effective antitumor immune responses, as well as overcome immune evasion and tolerance mechanisms mediated by progressing tumor. Previous studies showed that IL-13Rα2, a unique tumor-associated Ag, is a promising target for cancer immunotherapy. A targeted cytotoxin composed of IL-13 and mutated Pseudomonas exotoxin induced specific killing of IL-13Rα2(+) tumor cells. When combined with IL-13Rα2 DNA cancer vaccine, surprisingly, it mediated synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. The mechanism of synergistic activity involved direct killing of tumor cells and cell-mediated immune responses, as well as elimination of myeloid-derived suppressor cells and, consequently, regulatory T cells. These novel results provide a strong rationale for combining immunotoxins with cancer vaccines for the treatment of patients with advanced cancer. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Nakashima, Hideyuki AU - Terabe, Masaki AU - Berzofsky, Jay A AU - Husain, Syed R AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 4935 EP - 4946 VL - 187 IS - 10 KW - Bacterial Toxins KW - 0 KW - Cancer Vaccines KW - Exotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Vaccines, DNA KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Cell Line, Tumor KW - Mice, Inbred BALB C KW - Drug Synergism KW - Female KW - Mice, Knockout KW - Vaccines, DNA -- immunology KW - Vaccines, DNA -- therapeutic use KW - Sarcoma, Experimental -- genetics KW - Interleukin-13 Receptor alpha2 Subunit -- biosynthesis KW - ADP Ribose Transferases -- genetics KW - Mammary Neoplasms, Experimental -- therapy KW - Bacterial Toxins -- genetics KW - Cancer Vaccines -- immunology KW - Bacterial Toxins -- therapeutic use KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Exotoxins -- genetics KW - ADP Ribose Transferases -- immunology KW - Gene Targeting -- methods KW - Virulence Factors -- therapeutic use KW - Cancer Vaccines -- therapeutic use KW - Mammary Neoplasms, Experimental -- genetics KW - Virulence Factors -- genetics KW - Exotoxins -- immunology KW - Bacterial Toxins -- immunology KW - Virulence Factors -- immunology KW - ADP Ribose Transferases -- therapeutic use KW - Immunotherapy -- methods KW - Interleukin-13 Receptor alpha2 Subunit -- therapeutic use KW - Sarcoma, Experimental -- therapy KW - Cancer Vaccines -- genetics KW - Exotoxins -- therapeutic use KW - Mammary Neoplasms, Experimental -- immunology KW - Sarcoma, Experimental -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902340963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=A+novel+combination+immunotherapy+for+cancer+by+IL-13R%CE%B12-targeted+DNA+vaccine+and+immunotoxin+in+murine+tumor+models.&rft.au=Nakashima%2C+Hideyuki%3BTerabe%2C+Masaki%3BBerzofsky%2C+Jay+A%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Nakashima&rft.aufirst=Hideyuki&rft.date=2011-11-15&rft.volume=187&rft.issue=10&rft.spage=4935&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1102095 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-09 N1 - Date created - 2011-11-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell. 1992 Mar 6;68(5):855-67 [1547487] Cancer Res. 1992 Mar 15;52(6):1399-405 [1540948] Blood. 1996 May 15;87(10):4333-9 [8639793] J Biol Chem. 1996 Jul 12;271(28):16921-6 [8663118] Tissue Antigens. 1996 May;47(5):414-21 [8795142] J Clin Invest. 1998 Feb 15;101(4):746-54 [9466968] Clin Cancer Res. 1997 Feb;3(2):151-6 [9815666] J Immunol. 2005 Jan 15;174(2):636-45 [15634881] Protein Expr Purif. 2005 Feb;39(2):189-98 [15642470] Cancer Res. 2005 Apr 15;65(8):3044-8 [15833831] Curr Top Microbiol Immunol. 2005;293:287-302 [15981485] Nat Rev Immunol. 2005 Aug;5(8):641-54 [16056256] Cancer Res. 2005 Sep 15;65(18):8059-64 [16166275] Clin Cancer Res. 2005 Sep 15;11(18):6713-21 [16166452] Cancer Res. 2006 Jan 15;66(2):1123-31 [16424049] Cancer Res. 2006 Apr 15;66(8):4434-42 [16618770] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Clin Cancer Res. 2006 Aug 1;12(15):4678-86 [16899618] J Clin Invest. 2006 Oct;116(10):2587-90 [17016554] J Clin Invest. 2006 Oct;116(10):2777-90 [17016559] J Exp Med. 2006 Nov 27;203(12):2691-702 [17101732] Annu Rev Med. 2007;58:221-37 [17059365] J Clin Oncol. 2007 Mar 1;25(7):837-44 [17327604] Annu Rev Immunol. 2007;25:267-96 [17134371] Cancer Res. 2007 Jun 1;67(11):5067-9 [17545581] Vaccine. 2007 Sep 27;25 Suppl 2:B89-96 [17573164] Nat Rev Cancer. 2008 Feb;8(2):108-20 [18219306] Cancer Immunol Immunother. 2009 Jan;58(1):49-59 [18446337] Int J Cancer. 2009 Mar 15;124(6):1440-8 [19065664] Nat Rev Immunol. 2009 Mar;9(3):162-74 [19197294] Cancer Res. 2009 Nov 15;69(22):8678-85 [19887609] J Transl Med. 2010;8:116 [21067607] Int J Cancer. 2011 Mar 1;128(5):1221-31 [20473925] Clin Cancer Res. 2011 Jun 1;17(11):3520-6 [21471425] J Immunol. 2000 Mar 15;164(6):3112-22 [10706701] Cancer Res. 2000 Mar 1;60(5):1168-72 [10728667] Int J Cancer. 2001 Apr 15;92(2):168-75 [11291041] J Immunol. 2001 May 1;166(9):5398-406 [11313376] Vaccine. 2002 Dec 19;20 Suppl 4:A2-7 [12477422] Cancer Res. 2003 Aug 1;63(15):4441-9 [12907617] J Immunol. 2003 Sep 15;171(6):2889-95 [12960311] J Immunol. 2004 Feb 1;172(3):1540-7 [14734732] Cancer. 2004 Sep 1;101(5):1036-42 [15329913] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 1995 Nov 1;182(5):1301-14 [7595201] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4049/jimmunol.1102095 ER - TY - CPAPER T1 - Multiplex PCR for the detection of insects in food T2 - 59th Annual Meeting of the Entomological Society of America AN - 1313021832; 6063195 JF - 59th Annual Meeting of the Entomological Society of America AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Miller, Amy AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - insects KW - Polymerase chain reaction KW - Food KW - Aquatic insects KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Multiplex+PCR+for+the+detection+of+insects+in+food&rft.au=Pava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BMiller%2C+Amy%3BZiobro%2C+George&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Could incidental storage insect pests be potential food allergens? T2 - 59th Annual Meeting of the Entomological Society of America AN - 1313021590; 6063191 JF - 59th Annual Meeting of the Entomological Society of America AU - Goeriz Pearson, Rachel AU - Pava-Ripoll, Monica AU - Miller, Amy AU - Opit, George AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - pests KW - Storage KW - Allergens KW - insects KW - Food hypersensitivity KW - Pests KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Could+incidental+storage+insect+pests+be+potential+food+allergens%3F&rft.au=Goeriz+Pearson%2C+Rachel%3BPava-Ripoll%2C+Monica%3BMiller%2C+Amy%3BOpit%2C+George%3BZiobro%2C+George&rft.aulast=Goeriz+Pearson&rft.aufirst=Rachel&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Are foodborne pathogens vertically transmitted in the house fly? T2 - 59th Annual Meeting of the Entomological Society of America AN - 1312918654; 6062892 JF - 59th Annual Meeting of the Entomological Society of America AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Miller, Amy AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - Residential areas KW - Pathogens KW - Housing KW - Food KW - Disease transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312918654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Are+foodborne+pathogens+vertically+transmitted+in+the+house+fly%3F&rft.au=Pava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BMiller%2C+Amy%3BZiobro%2C+George&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Study of a non-flammable liquid as an insect preservative T2 - 59th Annual Meeting of the Entomological Society of America AN - 1312915855; 6063060 JF - 59th Annual Meeting of the Entomological Society of America AU - Miller, Amy AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - Preservatives KW - insects KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312915855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Study+of+a+non-flammable+liquid+as+an+insect+preservative&rft.au=Miller%2C+Amy%3BPava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BZiobro%2C+George&rft.aulast=Miller&rft.aufirst=Amy&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Age-related blood-brain barrier dysfunction from substances of abuse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313093088; 6103711 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Trickler, W AU - Robinson, B AU - Lantz, S AU - Newport, G AU - Schlager, J AU - Paule, M AU - Slikker, Jr., W. AU - Hussain, S AU - Ali, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Drug abuse KW - Blood-brain barrier KW - Age UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313093088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Age-related+blood-brain+barrier+dysfunction+from+substances+of+abuse&rft.au=Trickler%2C+W%3BRobinson%2C+B%3BLantz%2C+S%3BNewport%2C+G%3BSchlager%2C+J%3BPaule%2C+M%3BSlikker%2C+Jr.%2C+W.%3BHussain%2C+S%3BAli%2C+S&rft.aulast=Trickler&rft.aufirst=W&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Changes in gene expression profile in response to inhalation anesthesia in developing rat brain T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313004244; 6103250 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Paule, M AU - Liu, F AU - Lei, G AU - Shi, L AU - Zhang, J AU - Sadovova, N AU - Hanig, J AU - Slikker, Jr., W. AU - Wang, C Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Inhalation KW - Brain KW - anesthesia KW - Gene expression KW - Anesthesia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313004244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Changes+in+gene+expression+profile+in+response+to+inhalation+anesthesia+in+developing+rat+brain&rft.au=Paule%2C+M%3BLiu%2C+F%3BLei%2C+G%3BShi%2C+L%3BZhang%2C+J%3BSadovova%2C+N%3BHanig%2C+J%3BSlikker%2C+Jr.%2C+W.%3BWang%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Noise and Hearing Loss Prevention Workshop T2 - 2011 ASME International Mechanical Engineering Congress & Exposition (ASME 2011) AN - 1312987688; 6114032 JF - 2011 ASME International Mechanical Engineering Congress & Exposition (ASME 2011) AU - Azman, Amanda Y1 - 2011/11/11/ PY - 2011 DA - 2011 Nov 11 KW - Hearing loss KW - Prevention KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312987688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+ASME+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2011%29&rft.atitle=Noise+and+Hearing+Loss+Prevention+Workshop&rft.au=Azman%2C+Amanda&rft.aulast=Azman&rft.aufirst=Amanda&rft.date=2011-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+ASME+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress2011/TechnicalProgramOverview.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Preparative separation of 1,3,6-pyrenetrisulfonic acid trisodium salt from the color additive D&; C Green No. 8 (pyranine) by pH-zone-refining counter-current chromatography AN - 1266755407; 15913333 AB - In developing analytical methods for batch certification of the color additive D&C Green No. 8 (G8), the U.S. Food and Drug Administration needed the trisodium salt of 1,3,6-pyrenetrisulfonic acid (P3S) for use as a reference material. Since P3S was not commercially available, preparative quantities of it were separated from portions of a sample of G8 that contained [approx]3.5% P3S. The separations were performed by pH-zone-refining counter-current chromatography using dodecylamine (DA) as the hydrophobic counterion. The added DA enabled partitioning of the polysulfonated components into the organic stationary phase of the two-phase solvent system used, 1-butanol-water (1:1). Thus, a typical separation that involved 20.3 g of G8, using sulfuric acid as the retainer acid and 20% DA in the stationary phase and 0.1 M sodium hydroxide as the mobile phase, resulted in [approx]0.58 g of P3S of greater than 99% purity. The identification and characterization of the separated P3S were performed by elemental analyses, proton nuclear magnetic resonance, high-resolution mass spectrometry, ultra-violet spectra, and high-performance liquid chromatography. JF - Journal of Chromatography A AU - Weisz, Adrian AU - Mazzola, Eugene P AU - Ito, Yoichiro AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-106, 5100 Paint Branch Parkway, College Park, MD 20740, USA, adrian.weisz@fda.hhs.gov Y1 - 2011/11/11/ PY - 2011 DA - 2011 Nov 11 SP - 8249 EP - 8254 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 45 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Counter-current chromatography KW - pH-zone-refining CCC KW - Pyranine KW - D&C Green No. 8 KW - Dyes KW - 8-Hydroxy-1,3,6-pyrenetrisulfonic acid KW - 1,3,6-Pyrenetrisulfonic acid KW - Mass Spectrometry KW - Chromatographic techniques KW - Colour KW - Certification KW - Drugs KW - Sulfuric Acid KW - Chromatography KW - Solvents KW - Color KW - Salts KW - Foods KW - Analytical Methods KW - Acids KW - Hydroxides KW - Nuclear magnetic resonance KW - Additives KW - Sulphuric acid KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266755407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Preparative+separation+of+1%2C3%2C6-pyrenetrisulfonic+acid+trisodium+salt+from+the+color+additive+D%26amp%3B%3B+C+Green+No.+8+%28pyranine%29+by+pH-zone-refining+counter-current+chromatography&rft.au=Weisz%2C+Adrian%3BMazzola%2C+Eugene+P%3BIto%2C+Yoichiro&rft.aulast=Weisz&rft.aufirst=Adrian&rft.date=2011-11-11&rft.volume=1218&rft.issue=45&rft.spage=8249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.09.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Colour; Chromatographic techniques; Solvents; Certification; Nuclear magnetic resonance; Hydroxides; Drugs; Additives; Sulphuric acid; Sulfuric Acid; Mass Spectrometry; Salts; Foods; Chromatography; Analytical Methods; Acids; Color DO - http://dx.doi.org/10.1016/j.chroma.2011.09.049 ER - TY - JOUR T1 - Rapid and simultaneous determination of hexapeptides (Ac-EEMQRR-amide and H sub(2N-EEMQRR-amide) in anti-wrinkle cosmetics by hydrophilic interaction liquid chromatography-solid phase extraction preparation and hydrophilic interaction liquid chromatography with tandem mass spectrometry) AN - 1635020915; 15912103 AB - A rapid method for the simultaneous determination of Ac-EEMQRR-amide and H sub(2N-EEMQRR-amide in cosmetic products was developed and evaluated. This analytical procedure involved extracting samples with 0.1:0.1:85:15 (v:v) trifluoroacetic acid (TFA):formic acid:acetonitrile (ACN):water and determination by hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC-MS/MS). Samples showing serious ion suppression were further cleaned up using HILIC-SPE prior to HILIC-MS/MS analysis. Stable isotopically labeled peptides, corresponding to the above two peptides, were used as internal standards to correct for loss of recovery and matrix effects. Electrospray ionization (ESI) in the positive mode was used. The linear range was 2.0-1000 ng/mL for Ac-EEMQRR-amide and 25.0-2500 ng/mL for H) sub(2)N-EEMQRR-amide. Thirteen commercial products were analyzed for the two peptides using this method. The amounts of Ac-EEMQRR-amide in the samples ranged from none detected to 42.3 mu g/g. H sub(2N-EEMQRR-amide was not detected in any of the samples. The recoveries for Ac-EEMQRR-amide and H) sub(2)N-EEMQRR-amide ranged from 85% to 110% and 84% to 119%, respectively, at the spiking level of 30 mu g/g. JF - Journal of Chromatography A AU - Zhou, Wanlong AU - Wang, Perry G AU - Krynitsky, Alexander J AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA, Perry.Wang@fda.hhs.gov Y1 - 2011/11/04/ PY - 2011 DA - 2011 Nov 04 SP - 7956 EP - 7963 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 44 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Acetyl hexapeptide KW - HILIC KW - ESI KW - MS/MS KW - SPE KW - Stable isotopically labeled peptides KW - Mass Spectrometry KW - Chromatographic techniques KW - Mass spectroscopy KW - Acids KW - Analytical techniques KW - Liquid Chromatography KW - Standards KW - Peptides KW - Ionization KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635020915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Rapid+and+simultaneous+determination+of+hexapeptides+%28Ac-EEMQRR-amide+and+H+sub%282N-EEMQRR-amide%29+in+anti-wrinkle+cosmetics+by+hydrophilic+interaction+liquid+chromatography-solid+phase+extraction+preparation+and+hydrophilic+interaction+liquid+chromatography+with+tandem+mass+spectrometry%29&rft.au=Zhou%2C+Wanlong%3BWang%2C+Perry+G%3BKrynitsky%2C+Alexander+J%3BRader%2C+Jeanne+I&rft.aulast=Zhou&rft.aufirst=Wanlong&rft.date=2011-11-04&rft.volume=1218&rft.issue=44&rft.spage=7956&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.08.091 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Analytical techniques; Peptides; Mass spectroscopy; Mass Spectrometry; Acids; Liquid Chromatography; Standards; Ionization DO - http://dx.doi.org/10.1016/j.chroma.2011.08.091 ER - TY - JOUR T1 - Early-Life Exposures and Early-Onset Uterine Leiomyomata in Black Women in the Sister Study AN - 1660045767; 16537011 AB - Background: Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. Objectives: We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women. Methods: We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models. Results: Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula. Conclusions: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development. JF - Environmental Health Perspectives AU - D'Aloisio, Aimee A AU - Baird, Donna D AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 406 EP - 412 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - diabetes mellitus KW - diethylstilbestrol KW - early-life KW - leiomyoma KW - multiple birth offspring KW - pregnancy KW - pregnancy-induced hypertension KW - prenatal exposure delayed effects KW - socioeconomic factors KW - soy formula KW - Birth KW - Risk KW - Age KW - Mathematical models KW - Exposure KW - Breast KW - Disorders KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660045767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Early-Life+Exposures+and+Early-Onset+Uterine+Leiomyomata+in+Black+Women+in+the+Sister+Study&rft.au=D%27Aloisio%2C+Aimee+A%3BBaird%2C+Donna+D%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=D%27Aloisio&rft.aufirst=Aimee&rft.date=2011-11-02&rft.volume=120&rft.issue=3&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1103620 ER - TY - JOUR T1 - Assessment of Occupational Cosmic Radiation Exposure of Flight Attendants Using Questionnaire Data AN - 968168138; 16120706 AB - Introduction: Female flight attendants may have a higher risk of breast and other cancers than the general population because of routine exposure to cosmic radiation. As part of a forthcoming study of breast and other cancer incidence, occupational cosmic radiation exposure of a cohort of female flight attendants was estimated. Methods: Questionnaire data were collected from living female cohort members who were formerly employed as flight attendants with Pan American World Airways. These data included airline at which the flight attendant was employed, assigned domicile, start and end dates for employment at domicile, and number of block hours and commuter segments flown per month. Questionnaire respondents were assigned daily absorbed and effective doses using a time-weighted dose rate specific to the domicile and/or work history era combined with self-reported work history information. Results: Completed work history questionnaires were received from 5898 living cohort members. Mean employment time as a flight attendant was 7.4 yr at Pan Am and 12 yr in total. Estimated mean annual effective dose from all sources of occupational cosmic radiation exposure was 2.5 plus or minus 1.0 mSv, with a mean career dose of 30 mSv. Discussion: Annual effective doses were similar to doses assessed for other flight attendant cohorts; however, questionnaire-based cumulative doses assessed in this study were on average higher than those assessed for other flight attendant cohorts using company-based records. The difference is attributed to the inclusion of dose from work at other airlines and commuter flights, which was made possible by using questionnaire data. JF - Aviation, Space, and Environmental Medicine AU - Anderson, Jeri L AU - Waters, Martha A AU - Hein, Misty J AU - Schubauer-Berigan, Mary K AU - Pinkerton, Lynne E AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy , MS R-14, Cincinnati, OH 45226, jlanderson@cdc.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1049 EP - 1054 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 82 IS - 11 SN - 0095-6562, 0095-6562 KW - Health & Safety Science Abstracts KW - careers KW - Historical account KW - employment KW - Dose-response effects KW - airlines KW - Cosmic radiation KW - Occupational exposure KW - Cancer KW - crew safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968168138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.atitle=Assessment+of+Occupational+Cosmic+Radiation+Exposure+of+Flight+Attendants+Using+Questionnaire+Data&rft.au=Anderson%2C+Jeri+L%3BWaters%2C+Martha+A%3BHein%2C+Misty+J%3BSchubauer-Berigan%2C+Mary+K%3BPinkerton%2C+Lynne+E&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2011-11-01&rft.volume=82&rft.issue=11&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/10.3357%2FASEM.3091.2011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - careers; Historical account; employment; airlines; Dose-response effects; Cosmic radiation; Cancer; Occupational exposure; crew safety DO - http://dx.doi.org/10.3357/ASEM.3091.2011 ER - TY - JOUR T1 - Understanding and Quantifying Arc Flash Hazards in the Mining Industry AN - 963909176; 16078128 AB - Arc flash generally refers to the dangerous exposure to thermal energy released by an arcing fault on an electrical power system, and in recent years, arc flash hazards have become a prominent safety issue in many industries. This problem, however, has not been effectively addressed in the mining industry. Mine Safety and Health Administration (MSHA) data for the period 1990 through 2001 attribute 836 injuries to "noncontact electric arc burns," making them the most common cause of electrical injury in mining. This paper presents results from several elements of a recent National Institute for Occupational Safety and Health study of arc flash hazards in mining and provides information and recommendations that can help reduce these injuries. The characteristics of past arc flash injuries in mining are first outlined, such as the electrical components and work activities involved (based on MSHA data). This is followed by a review of important concepts and terminology needed to understand this hazard. Next, methods for identifying, measuring, and managing arc flash hazards on a power system are covered, with emphasis on recommendations found in NFPA 70E, Standard for Electrical Safety in the Workplace. Finally, results are presented from a detailed arc flash hazard analysis performed on a sample mine electrical power system using IEEE 1584-2004a, focusing on components and locations presenting severe hazards, as well as engineering solutions for reducing the risk to personnel. JF - IEEE Transactions on Industry Applications AU - Homce, Gerald T AU - Cawley, James C AD - U.S. Department of Health and Human Services, Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, PA, USA Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 2437 EP - 2444 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 47 IS - 6 SN - 0093-9994, 0093-9994 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Burns KW - Electric power KW - safety engineering KW - Safety regulations KW - Injuries KW - Safety engineering KW - Reviews KW - Occupational safety KW - Mining KW - Risk reduction KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/963909176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Industry+Applications&rft.atitle=Understanding+and+Quantifying+Arc+Flash+Hazards+in+the+Mining+Industry&rft.au=Homce%2C+Gerald+T%3BCawley%2C+James+C&rft.aulast=Homce&rft.aufirst=Gerald&rft.date=2011-11-01&rft.volume=47&rft.issue=6&rft.spage=2437&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Industry+Applications&rft.issn=00939994&rft_id=info:doi/10.1109%2FTIA.2011.2169170 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Burns; Electric power; Safety regulations; safety engineering; Safety engineering; Injuries; Reviews; Occupational safety; Risk reduction; Mining DO - http://dx.doi.org/10.1109/TIA.2011.2169170 ER - TY - JOUR T1 - Serum total and HDL cholesterol and risk of prostate cancer AN - 926884750; 16351686 AB - Background: Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed. Methods: We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n = 29,093). Cox proportional hazards models were used to estimate the relative risk of total (n = 2,041), non-aggressive (n = 829), aggressive (n = 461), advanced (n = 412), and high-grade (n = 231) prostate cancer by categories of total and HDL cholesterol. Results: After excluding the first 10 years of follow-up, men with higher serum total cholesterol were at increased risk of overall ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03-1.44, p-trend = 0 .01) and advanced ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13-3.03, p-trend = 0 .05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade. Conclusions: In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, Rockville, MD, 20852, USA, mondulam@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1545 EP - 1552 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 11 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Cholesterol KW - Prostate cancer KW - Risk reduction KW - Statins KW - cholesterol KW - prostate cancer KW - risk reduction KW - statins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926884750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Serum+total+and+HDL+cholesterol+and+risk+of+prostate+cancer&rft.au=Mondul%2C+Alison+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-11-01&rft.volume=22&rft.issue=11&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9831-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - risk reduction; Statins; Prostate cancer; statins; Risk reduction; Cholesterol; prostate cancer; cholesterol; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9831-7 ER - TY - JOUR T1 - In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos AN - 911168007; 16084777 AB - We describe an imaging procedure to measure axon length in zebrafish embryos in vivo. Automated fluorescent image acquisition was performed with the ImageXpress Micro high content screening reader and further analysis of axon lengths was performed on archived images using AcuityXpress software. We utilized the Neurite Outgrowth Application module with a customized protocol (journal) to measure the axons. Since higher doses of ethanol (2-2.5%, v/v) have been shown to deform motor neurons and axons during development, here we used ethanol to treat transgenic [hb9:GFP (green fluorescent protein)] zebrafish embryos at 28 hpf (hours post-fertilization). These embryos express GFP in the motor neurons and their axons. Embryos after ethanol treatment were arrayed in 384-well plates for automated fluorescent image acquisition in vivo. Average axon lengths of high dose ethanol-treated embryos were significantly lower than the control. Another experiment showed that there was no significant difference in the axon lengths between the embryos grown for 24h at 22 degree C and 28.5 degree C. These test experiments demonstrate that using axon development as an end-point, compound screening can be performed in a time-efficient manner. JF - Neurotoxicology and Teratology AU - Kanungo, Jyotshnabala AU - Lantz, Susan AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States, jyotshnabala.kanungo@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 618 EP - 623 PB - Elsevier B.V., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 33 IS - 6 SN - 0892-0362, 0892-0362 KW - ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Zebrafish KW - Transgenic embryo KW - Axon KW - High content imaging KW - Ethanol KW - Screening KW - Green fluorescent protein KW - Embryonic development KW - Development KW - Freshwater KW - Freshwater fish KW - Imaging techniques KW - Danio rerio KW - Motor neurons KW - Computer programs KW - software KW - Neurons KW - Teratology KW - Axonogenesis KW - Axons KW - Embryos KW - Archives KW - N3 11028:Neuropharmacology & toxicology KW - Q1 08344:Reproduction and development KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=In+vivo+imaging+and+quantitative+analysis+of+changes+in+axon+length+using+transgenic+zebrafish+embryos&rft.au=Kanungo%2C+Jyotshnabala%3BLantz%2C+Susan%3BPaule%2C+Merle+G&rft.aulast=Kanungo&rft.aufirst=Jyotshnabala&rft.date=2011-11-01&rft.volume=33&rft.issue=6&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2011.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Screening; Neurons; Teratology; Embryonic development; Embryos; Archives; Freshwater fish; Imaging techniques; Computer programs; Motor neurons; software; Green fluorescent protein; Axonogenesis; Axons; Development; Ethanol; Danio rerio; Freshwater DO - http://dx.doi.org/10.1016/j.ntt.2011.08.013 ER - TY - JOUR T1 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the National Health and Nutrition Examination Survey 1999-2002 AN - 911155124; 15965247 AB - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the National Health and Nutrition Examination Survey 1999-2002. The blood lead levels of the women ranged from 0.2 to 17.0 mu g/dL. The estimated geometric mean was 1.4 mu g/dL, and the estimated arithmetic mean was 1.6 mu g/dL. As the blood lead level increased, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 0.9 mu g/dL for follicle stimulating hormone and 3.2 mu g/dL for luteinizing hormone. Lead may act directly or indirectly at ovarian and non-ovarian sites to increase the concentrations of follicle stimulating hormone and luteinizing hormone. JF - Reproductive Toxicology AU - Krieg, Edward F AU - Feng, Huiling A AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, United States, erk3@cdc.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 277 EP - 285 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 32 IS - 3 SN - 0890-6238, 0890-6238 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Follicles KW - Hormones KW - Nutrition KW - Lead KW - Blood levels KW - Mathematics KW - Blood KW - Luteinizing hormone KW - Ovaries KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=The+relationships+between+blood+lead+levels+and+serum+follicle+stimulating+hormone+and+luteinizing+hormone+in+the+National+Health+and+Nutrition+Examination+Survey+1999-2002&rft.au=Krieg%2C+Edward+F%3BFeng%2C+Huiling+A&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2011-11-01&rft.volume=32&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2011.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Blood; Follicles; Luteinizing hormone; Ovaries; Nutrition; Hormones; Lead; Mathematics; Blood levels DO - http://dx.doi.org/10.1016/j.reprotox.2011.05.012 ER - TY - JOUR T1 - The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats. AN - 904223451; 21373894 AB - The iron chelator Dp44mT is a potent topoisomerase IIα inhibitor with novel anticancer activity. Doxorubicin (Dox), the current front-line therapy for breast cancer, induces a dose-limiting cardiotoxicity, in part through an iron-mediated pathway. We tested the hypothesis that Dp44mT can improve clinical outcomes of treatment with Dox by alleviating cardiotoxicity. The general cardiac and renal toxicities induced by Dox were investigated in the presence and absence of Dp44mT. The iron chelating cardioprotectant Dexrazoxane (Drz), which is approved for this indication, was used as a positive control. In vitro studies were carried out with H9c2 rat cardiomyocytes and in vivo studies were performed using spontaneously hypertensive rats. Testing of the GI(50) profile of Dp44mT in the NCI-60 panel confirmed activity against breast cancer cells. An acute, toxic dose of Dox caused the predicted cellular and cardiac toxicities, such as cell death and DNA damage in vitro and elevated cardiac troponin T levels, tissue damage, and apoptosis in vivo. Dp44mT alone caused insignificant changes in hematological and biochemical indices in rats, indicating that Dp44mT is not significantly cardiotoxic as a single agent. In contrast to Drz, Dp44mT failed to mitigate Dox-induced cardiotoxicity in vivo. We conclude that although Dp44mT is a potent iron chelator, it is unlikely to be an appropriate cardioprotectant against Dox-induced toxicity. However, it should continue to be evaluated as a potential anticancer agent as it has a novel mechanism for inhibiting the growth of a broad range of malignant cell types while exhibiting very low intrinsic toxicity to healthy tissues. JF - Cancer chemotherapy and pharmacology AU - Rao, V Ashutosh AU - Zhang, Jun AU - Klein, Sarah R AU - Espandiari, Parvaneh AU - Knapton, Alan AU - Dickey, Jennifer S AU - Herman, Eugene AU - Shacter, Emily B AD - Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A-11, Bethesda, MD 20892, USA. ashutosh.rao@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1125 EP - 1134 VL - 68 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Iron Chelating Agents KW - Thiosemicarbazones KW - Troponin T KW - di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred SHR KW - Troponin T -- metabolism KW - Humans KW - Apoptosis -- drug effects KW - Cell Line, Tumor KW - Immunohistochemistry KW - Male KW - Cell Proliferation -- drug effects KW - Antineoplastic Agents -- toxicity KW - Heart -- drug effects KW - Doxorubicin -- toxicity KW - Thiosemicarbazones -- pharmacology KW - Iron Chelating Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904223451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=The+iron+chelator+Dp44mT+inhibits+the+proliferation+of+cancer+cells+but+fails+to+protect+from+doxorubicin-induced+cardiotoxicity+in+spontaneously+hypertensive+rats.&rft.au=Rao%2C+V+Ashutosh%3BZhang%2C+Jun%3BKlein%2C+Sarah+R%3BEspandiari%2C+Parvaneh%3BKnapton%2C+Alan%3BDickey%2C+Jennifer+S%3BHerman%2C+Eugene%3BShacter%2C+Emily+B&rft.aulast=Rao&rft.aufirst=V&rft.date=2011-11-01&rft.volume=68&rft.issue=5&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-011-1587-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-011-1587-y ER - TY - JOUR T1 - Signal detection of methylphenidate by comparing a spontaneous reporting database with a claims database. AN - 903663261; 21510997 AB - Data mining is critical for signal detection in pharmacovigilance systems. In this study, we compared signals between spontaneous reporting data and health insurance claims data for a socially issued drug, methylphenidate. We implemented data-mining tools for signal detection in both databases: Reporting Odds Ratios (ROR), Proportional Reporting Ratios (PRR), Chi-squared test, and Information Component (IC), in addition to a Relative Risk (RR) tool in the claims database. The claims database generated 15, 15, 36, 1, and 1 adverse drug reactions (ADRs) by ROR, PRR, chi-square, IC, and RR, respectively. The World Health Organization (WHO) spontaneous database generated 91, 91, 137, and 96 ADRs by ROR, PRR, chi-square, and IC, respectively. We found seven potential matching associations from the claims and WHO databases, but only one of them was present in the Korean spontaneous reporting database. In Korea, spontaneous reporting is still underreported and there is a small amount of data for Koreans. Signal comparison between the claims and WHO databases can provide additional regulatory insight. Copyright © 2011. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Kim, JaYoung AU - Kim, Munsin AU - Ha, Ji-Hye AU - Jang, Junghoon AU - Hwang, Myungsil AU - Lee, Byung Koo AU - Chung, Myeon Woo AU - Yoo, Tae Moo AU - Kim, Myung Jung AD - Pharmaceutical Safety Bureau, Korea Food and Drug Administration, Osong 363-951, Republic of Korea. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 154 EP - 160 VL - 61 IS - 2 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Risk KW - Republic of Korea KW - Pharmacovigilance KW - Odds Ratio KW - Signal Detection, Psychological KW - Drug-Related Side Effects and Adverse Reactions -- chemically induced KW - Humans KW - Data Mining -- methods KW - Research Report KW - Insurance Claim Reporting KW - Adverse Drug Reaction Reporting Systems KW - Methylphenidate -- adverse effects KW - Databases, Factual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/903663261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Signal+detection+of+methylphenidate+by+comparing+a+spontaneous+reporting+database+with+a+claims+database.&rft.au=Kim%2C+JaYoung%3BKim%2C+Munsin%3BHa%2C+Ji-Hye%3BJang%2C+Junghoon%3BHwang%2C+Myungsil%3BLee%2C+Byung+Koo%3BChung%2C+Myeon+Woo%3BYoo%2C+Tae+Moo%3BKim%2C+Myung+Jung&rft.aulast=Kim&rft.aufirst=JaYoung&rft.date=2011-11-01&rft.volume=61&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-16 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.03.015 ER - TY - JOUR T1 - Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose AN - 902378726; 15839077 AB - The lichen metabolite usnic acid (UA) has been promoted as a dietary supplement for weight loss, although cases of hepatotoxicity have been reported. Here we evaluated UA-associated hepatotoxicity in vitro using isolated rat hepatocytes. We measured cell viability and ATP content to evaluate UA induced cytotoxicity and applied 13C isotopomer distribution measuring techniques to gain a better understanding of glucose metabolism during cytotoxicity. The cells were exposed to 0, 1, 5 or 10 mu M UA concentrations for 2, 6 or 24h. Aliquots of media were collected at the end of these time periods and the 13C mass isotopomer distribution determined for CO2, lactate, glucose and glutamate. The 1 mu M UA exposure did not appear to cause significant change in cell viability compared to controls. However, the 5 and 10 mu M UA concentrations significantly reduced cell viability as exposure time increased. Similar results were obtained for ATP depletion experiments. The 1 and 5 mu M UA doses suggest increased oxidative phosphorylation. Conversely, oxidative phosphorylation and gluconeogenesis were dramatically inhibited by 10 mu M UA. Augmented oxidative phosphorylation at the lower UA concentrations may be an adaptive response by the cells to compensate for diminished mitochondrial function. JF - Food and Chemical Toxicology AU - Sonko, Bakary J AU - Schmitt, Thomas C AU - Guo, Lei AU - Shi, Qiang AU - Boros, Laszlo G AU - Leakey, Julian EA AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA, Richard.Beger@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2968 EP - 2974 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 49 IS - 11 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Usnic acid KW - Hepatotoxicity KW - U-13C6-d-glucose KW - Mass isotopomer distribution analysis (MIDA) KW - Hepatocytes KW - Oxidative phosphorylation KW - Measuring techniques KW - Mitochondria KW - ATP KW - Metabolites KW - Glucose metabolism KW - Toxicity KW - hepatotoxicity KW - Body weight loss KW - Cytotoxicity KW - Lichens KW - Dietary supplements KW - Gluconeogenesis KW - Lactic acid KW - Glutamic acid KW - Carbon dioxide KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902378726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Assessment+of+usnic+acid+toxicity+in+rat+primary+hepatocytes+using+13C+isotopomer+distribution+analysis+of+lactate%2C+glutamate+and+glucose&rft.au=Sonko%2C+Bakary+J%3BSchmitt%2C+Thomas+C%3BGuo%2C+Lei%3BShi%2C+Qiang%3BBoros%2C+Laszlo+G%3BLeakey%2C+Julian+EA%3BBeger%2C+Richard+D&rft.aulast=Sonko&rft.aufirst=Bakary&rft.date=2011-11-01&rft.volume=49&rft.issue=11&rft.spage=2968&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2011.07.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Oxidative phosphorylation; Hepatocytes; Measuring techniques; ATP; Mitochondria; Metabolites; Toxicity; Glucose metabolism; hepatotoxicity; Body weight loss; Cytotoxicity; Lichens; Dietary supplements; Gluconeogenesis; Lactic acid; Usnic acid; Glutamic acid; Carbon dioxide DO - http://dx.doi.org/10.1016/j.fct.2011.07.047 ER - TY - JOUR T1 - Monte Carlo modeling of time-resolved fluorescence for depth-selective interrogation of layered tissue AN - 902367047; 15910522 AB - Computational approaches for simulation of light-tissue interactions have provided extensive insight into biophotonic procedures for diagnosis and therapy. However, few studies have addressed simulation of time-resolved fluorescence (TRF) in tissue and none have combined Monte Carlo simulations with standard TRF processing algorithms to elucidate approaches for cancer detection in layered biological tissue. In this study, we investigate how illumination-collection parameters (e.g., collection angle and source-detector separation) influence the ability to measure fluorophore lifetime and tissue layer thickness. Decay curves are simulated with a Monte Carlo TRF light propagation model. Multi-exponential iterative deconvolution is used to determine lifetimes and fractional signal contributions. The ability to detect changes in mucosal thickness is optimized by probes that selectively interrogate regions superficial to the mucosal-submucosal boundary. Optimal accuracy in simultaneous determination of lifetimes in both layers is achieved when each layer contributes 40-60% of the signal. These results indicate that depth-selective approaches to TRF have the potential to enhance disease detection in layered biological tissue and that modeling can play an important role in probe design optimization. JF - Computer Methods and Programs in Biomedicine AU - Pfefer, TJoshua AU - Wang, Quanzeng AU - Drezek, Rebekah A AD - Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, United States, joshua.pfefer@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 161 EP - 167 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 104 IS - 2 SN - 0169-2607, 0169-2607 KW - Biotechnology and Bioengineering Abstracts KW - Monte Carlo KW - Light-tissue interaction KW - Optical diagnostics KW - Cancer detection KW - Monte Carlo simulation KW - Fluorescence KW - Mucosa KW - Probes KW - Boundaries KW - Algorithms KW - fluorophores KW - Computer applications KW - Cancer KW - Light effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902367047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Monte+Carlo+modeling+of+time-resolved+fluorescence+for+depth-selective+interrogation+of+layered+tissue&rft.au=Pfefer%2C+TJoshua%3BWang%2C+Quanzeng%3BDrezek%2C+Rebekah+A&rft.aulast=Pfefer&rft.aufirst=TJoshua&rft.date=2011-11-01&rft.volume=104&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2010.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Fluorescence; Mucosa; Algorithms; Boundaries; Probes; fluorophores; Computer applications; Cancer; Light effects DO - http://dx.doi.org/10.1016/j.cmpb.2010.10.011 ER - TY - JOUR T1 - Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells. AN - 901306109; 21914638 AB - Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hydroxysteroid dehydrogenases (HSDs), 3β-HSD, HSD-17β1 and HSD-17β5 involved in metabolizing DHEA to testosterone (TESTO) were investigated. Individual depletion of HSDs in 6S cells significantly reduced TGF-β1/DHEA-induced PSA in LAPC-4 cells in cocultures. Monomer amounts of 3β-HSD were similar without or with TGF-β1 in both cell types but aggregates of 3β-HSD in 6S cells were much higher than those in LAPC-4 cells and were upregulated by TGFβ in 6S cells. Basal and TGF-β1-treated levels of HSD-17β1 and HSD-17β5 in LAPC-4 cells were significantly lower than in 6S cells, whereas levels of HSD-17β1 but not HSD-17β5 were TGFβ inducible. 6S cell HSD genes expression induced by TGFβ or androgen signaling was insignificant to contribute TGF-β1/DHEA-upregulated protein levels of HSDs. RC decreased TGF-β1- upregulation of aggregates of 3β-HSD but not HSD-17β1. Depletion of TGFβ receptors (TGFβ Rs) reduced TGF-β1/DHEA-upregulated HSDs and TESTO. Immunoprecipitation studies demonstrated that TGF-β1 disrupted associations of TGFβ Rs/HSDs aggregates, whereas RC suppressed the dissociations of aggregates of 3β-HSD but not HSD-17β1 from the receptors. Given that TGFβ Rs are recycled with or without ligand, TGF-β1-induced disassociation of the HSDs from TGFβ Rs may increase stability and activity of the HSDs. These data suggest a pathway connecting overproduction of TGFβ with increased PSA in prostate cancer. JF - Carcinogenesis AU - Liu, Xunxian AU - Piao, Yun-Shang AU - Arnold, Julia T AD - Endocrine Section, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. xunxianl@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1648 EP - 1654 VL - 32 IS - 11 KW - Isoflavones KW - 0 KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Testosterone KW - 3XMK78S47O KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - Hydroxysteroid Dehydrogenases KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Estradiol Dehydrogenases KW - EC 1.1.1.62 KW - HSD17B1 protein, human KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Prostatic Neoplasms -- metabolism KW - Estradiol Dehydrogenases -- antagonists & inhibitors KW - Receptors, Transforming Growth Factor beta -- genetics KW - Prostate -- drug effects KW - Immunoblotting KW - 3-Hydroxysteroid Dehydrogenases -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Humans KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Prostate -- metabolism KW - Immunoprecipitation KW - Hydroxyprostaglandin Dehydrogenases -- antagonists & inhibitors KW - Prostatic Neoplasms -- drug therapy KW - Hydroxyprostaglandin Dehydrogenases -- metabolism KW - Prostatic Neoplasms -- pathology KW - Estradiol Dehydrogenases -- genetics KW - Estradiol Dehydrogenases -- metabolism KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Cells, Cultured KW - Prostate-Specific Antigen -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Male KW - Testosterone -- metabolism KW - Stromal Cells -- drug effects KW - Isoflavones -- pharmacology KW - Hydroxysteroid Dehydrogenases -- metabolism KW - Hydroxysteroid Dehydrogenases -- genetics KW - Transforming Growth Factor beta1 -- pharmacology KW - Stromal Cells -- metabolism KW - Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Trifolium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+%CE%B21+increase+of+hydroxysteroid+dehydrogenase+proteins+is+partly+suppressed+by+red+clover+isoflavones+in+human+primary+prostate+cancer-derived+stromal+cells.&rft.au=Liu%2C+Xunxian%3BPiao%2C+Yun-Shang%3BArnold%2C+Julia+T&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-22 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostate. 2000 Oct 1;45(2):140-8 [11027413] Prostate. 2011 May 15;71(7):766-77 [21031436] Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78 [11252892] J Urol. 2001 Dec;166(6):2472-83 [11696814] Clin Cancer Res. 2002 Sep;8(9):2912-23 [12231536] Mol Biol Cell. 2004 Sep;15(9):4166-78 [15229286] N Engl J Med. 1986 Dec 25;315(26):1650-9 [3537791] Ann N Y Acad Sci. 1994 May 31;719:553-63 [8010623] Steroids. 1996 Jan;61(1):41-6 [8789735] Exp Cell Res. 1997 May 1;232(2):208-15 [9168795] Prostate. 1999 Jun 1;39(4):285-90 [10344218] Mech Ageing Dev. 2005 Jan;126(1):59-69 [15610763] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Endocrinology. 2006 Dec;147(12):5806-16 [16959841] Clin Dermatol. 2007 Jan-Feb;25(1):56-62 [17276202] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):207-21 [18471780] J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):240-6 [18621129] ChemMedChem. 2008 Sep;3(9):1371-6 [18576452] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Mol Cell Endocrinol. 2009 Mar 25;301(1-2):83-8 [19013497] Clin Cancer Res. 2009 Aug 1;15(15):4815-22 [19638459] Endocr Relat Cancer. 2009 Dec;16(4):1139-55 [19608712] Trends Immunol. 2010 Jun;31(6):220-7 [20538542] J Mol Endocrinol. 2001 Feb;26(1):11-9 [11174850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr206 ER - TY - JOUR T1 - Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. AN - 900627109; 21813462 AB - Because bisphenol A (BPA) exposure is nearly ubiquitous, increased knowledge of its potential effects on development will enable better risk assessment and regulatory guidance. Here, Sprague-Dawley rats were reared in low exogenous estrogen environments. After breeding at adulthood, dams were gavaged on gestational days (GDs) 6-21 with vehicle (VEH), 2.5 or 25.0 μg/kg/day BPA, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (EE₂). Offspring were orally treated on postnatal days (PNDs) 1-21 with the same dose the dam received. Relative to the VEH group, dams of both EE₂-treated groups weighed less throughout gestation and lactation. PND 1 absolute anogenital distance and anogenital index were unaltered by any treatment. Ages at fur development and eye and ear opening were unaffected by any treatment. Despite a significant treatment effect, no group was significantly different from VEH in PNDs 3-6 righting latencies; although males had shorter latencies and all latencies decreased with age. PNDs 8-11 slant board behavior was unaffected by any treatment; however, males had shorter turning latencies and latencies decreased with age. Preweaning body weights of BPA- and EE₂-treated groups as well as naive controls were less than VEH. No treatment affected PND 21 whole or regional brain weights or levels of estradiol, testosterone, corticosterone, T3, T4, luteinizing hormone, ghrelin, or leptin. These results add to the literature indicating that developmental BPA treatment at these doses has no effects on gestational or lactational body weight, offspring anogenital distance, preweaning behaviors or hormone levels, and whole and regional brain weights measured at weaning. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ferguson, Sherry A AU - Law, Charles D AU - Abshire, Jordan S AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. Sherry.Ferguson@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 149 EP - 160 VL - 124 IS - 1 KW - Benzhydryl Compounds KW - 0 KW - Hormones KW - Phenols KW - Ethinyl Estradiol KW - 423D2T571U KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Genitalia -- growth & development KW - Gestational Age KW - Hormones -- blood KW - Weaning KW - Pregnancy KW - Reflex, Righting -- drug effects KW - Rats KW - Genitalia -- drug effects KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - Body Weight -- drug effects KW - Male KW - Brain -- growth & development KW - Female KW - Proportional Hazards Models KW - Organ Size -- drug effects KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Phenols -- toxicity KW - Ethinyl Estradiol -- toxicity KW - Prenatal Exposure Delayed Effects -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Developmental+treatment+with+bisphenol+A+or+ethinyl+estradiol+causes+few+alterations+on+early+preweaning+measures.&rft.au=Ferguson%2C+Sherry+A%3BLaw%2C+Charles+D%3BAbshire%2C+Jordan+S&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2011-11-01&rft.volume=124&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr201 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Sci. 2013 Aug;134(2):428 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr201 ER - TY - JOUR T1 - Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. AN - 898839076; 21876048 AB - The veterinary cephalosporin drug ceftiofur is rapidly degraded in the bovine intestinal tract. A cylinder-plate assay was used to detect microbiologically active ceftiofur, and high-performance liquid chromatography-mass spectrometry analysis was used to quantify the amount of ceftiofur remaining after incubation with bovine intestinal anaerobic bacteria, which were isolated from colon contents or feces from 8 cattle. Ninety-six percent of the isolates were able to inactivate ceftiofur to some degree, and 54% actually degraded the drug. None of 9 fungal isolates inactivated or degraded ceftiofur. Facultative and obligate anaerobic bacterial species that inactivated or degraded ceftiofur were identified with Vitek and Biolog systems, respectively. A subset of ceftiofur degraders also degraded the chemically similar drug ceftriaxone. Most of the species of bacteria that degraded ceftiofur belonged to the genera Bacillus and Bacteroides. PCR analysis of bacterial DNA detected specific β-lactamase genes. Bacillus cereus and B. mycoides isolates produced extended-spectrum β-lactamases and metallo-β-lactamases. Seven isolates of Bacteroides spp. produced multiple β-lactamases, including possibly CepA, and metallo-β-lactamases. Isolates of Eubacterium biforme, Bifidobacterium breve, and several Clostridium spp. also produced ceftiofur-degrading β-lactamases. An agar gel overlay technique on isoelectric focusing separations of bacterial lysates showed that β-lactamase enzymes were sufficient to degrade ceftiofur. These results suggest that ceftiofur is inactivated nonenzymatically and degraded enzymatically by multiple β-lactamases from bacteria in the large intestines of cattle. JF - Antimicrobial agents and chemotherapy AU - Wagner, R Doug AU - Johnson, Shemedia J AU - Cerniglia, Carl E AU - Erickson, Bruce D AD - Microbiology Division, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. doug.wagner@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 4990 EP - 4998 VL - 55 IS - 11 KW - Cephalosporins KW - 0 KW - Ceftriaxone KW - 75J73V1629 KW - ceftiofur KW - 83JL932I1C KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Bacteroides -- metabolism KW - Eubacterium -- enzymology KW - Bacteroides -- enzymology KW - Bacillus cereus -- enzymology KW - Chromatography, High Pressure Liquid KW - Polymerase Chain Reaction KW - Clostridium -- metabolism KW - Cattle KW - Eubacterium -- metabolism KW - Bacillus cereus -- metabolism KW - Bifidobacterium -- enzymology KW - Bifidobacterium -- metabolism KW - Clostridium -- enzymology KW - Ceftriaxone -- metabolism KW - Cephalosporins -- metabolism KW - beta-Lactamases -- metabolism KW - Intestines -- microbiology KW - beta-Lactamases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898839076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Bovine+intestinal+bacteria+inactivate+and+degrade+ceftiofur+and+ceftriaxone+with+multiple+beta-lactamases.&rft.au=Wagner%2C+R+Doug%3BJohnson%2C+Shemedia+J%3BCerniglia%2C+Carl+E%3BErickson%2C+Bruce+D&rft.aulast=Wagner&rft.aufirst=R&rft.date=2011-11-01&rft.volume=55&rft.issue=11&rft.spage=4990&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00008-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-10 N1 - Date created - 2011-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Dec 27;284(24):3151-6 [11135779] J Comput Biol. 2000 Feb-Apr;7(1-2):203-14 [10890397] Antimicrob Agents Chemother. 2002 Jan;46(1):1-11 [11751104] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001 [11792842] Appl Environ Microbiol. 2002 Apr;68(4):1786-93 [11916697] Curr Top Med Chem. 2002 Jul;2(7):717-31 [12052187] Antimicrob Agents Chemother. 2002 Oct;46(10):3215-22 [12234847] Environ Res. 2003 Sep;93(1):45-51 [12865047] J Gen Microbiol. 1975 May;88(1):169-78 [807678] J Bacteriol. 1987 Feb;169(2):579-86 [3027036] Biochem J. 1987 Dec 15;248(3):657-62 [3124817] J Bacteriol. 1990 May;172(5):2584-93 [2110145] J Dairy Sci. 1992 Jul;75(7):1870-6 [1500583] Antimicrob Agents Chemother. 1992 Sep;36(9):1981-6 [1329636] Infection. 1993 Mar-Apr;21(2):127-30 [8491523] Antimicrob Agents Chemother. 1993 May;37(5):1028-36 [8517690] Antimicrob Agents Chemother. 1994 May;38(5):991-6 [8067782] Antimicrob Agents Chemother. 1994 Aug;38(8):1711-5 [7985999] J Chromatogr B Biomed Appl. 1995 Nov 17;673(2):231-44 [8611957] J Vet Diagn Invest. 1996 Jan;8(1):121-3 [9026069] J Pharm Sci. 1997 Mar;86(3):389-95 [9050811] J Vet Pharmacol Ther. 1998 Apr;21(2):112-20 [9597648] Mayo Clin Proc. 1999 Feb;74(2):187-95 [10069359] Antimicrob Agents Chemother. 2005 Oct;49(10):4061-7 [16189081] Appl Environ Microbiol. 2006 Jun;72(6):3940-8 [16751500] Am J Vet Res. 2006 Oct;67(10):1696-700 [17014318] Curr Microbiol. 2006 Nov;53(5):440-3 [17019644] J Clin Microbiol. 2007 Feb;45(2):544-7 [17093019] FEMS Microbiol Lett. 2008 Feb;279(2):162-6 [18093137] BMC Genomics. 2008;9:247 [18505588] BMC Microbiol. 2008;8:125 [18652685] Appl Environ Microbiol. 2008 Nov;74(22):6956-62 [18820057] Appl Environ Microbiol. 2009 Jun;75(11):3648-55 [19376926] Vet Microbiol. 2009 Oct 20;139(1-2):89-96 [19428193] Foodborne Pathog Dis. 2009 Oct;6(8):917-24 [19622032] Antimicrob Agents Chemother. 2010 Mar;54(3):969-76 [19995920] N Engl J Med. 2000 Apr 27;342(17):1242-9 [10781620] Clin Pharmacokinet. 2001;40(9):685-94 [11605716] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AAC.00008-11 ER - TY - JOUR T1 - Pelvic/Retroperitoneal Salvage Lymph Node Dissection for Patients Treated With Radical Prostatectomy With Biochemical Recurrence and Nodal Recurrence Detected by [11C]Choline Positron Emission Tomography/Computed Tomography AN - 1238122552; 15796492 AB - Background: The management of patients with clinical recurrence of prostate cancer after radical prostatectomy (RP) remains challenging. Objective: To determine whether the removal of positive lymph nodes at [11C]choline positron emission tomography/computed tomography (PET/CT) scan may have an impact on the prognosis of patients with biochemical recurrence (BCR) and nodal recurrence after RP. Design, setting, and participants: Prospective analysis of 72 patients affected by BCR after RP associated with a nodal pathologic [11C]choline PET/CT scan. Intervention: Patients underwent salvage lymph node dissection (LND). Measurements: Biochemical response (BR) to treatment was defined as prostate-specific antigen (PSA) 0.2 ng/ml at 40 d after salvage LND. Kaplan-Meier and Cox regression analyses addressed time to and predictors of clinical recurrence (CR) after salvage LND, respectively. Results and limitations: Overall, 56.9% of patients achieved BR. Mean and median follow-up after LND were 39.4 and 39.8 mo, respectively. The 5-yr BCR-free survival rate was 19%. Preoperative PSA 4 ng/ml (hazard ratio [HR]: 0.12; p = 0.005), time to BCR 24 mo (HR: 7.52; p = 0.005), and negative lymph nodes at previous RP (HR: 0.19; p = 0.04) represented independent predictors of BR. Overall, 5-yr CR-free and cancer-specific survival were 34% and 75%, respectively. At multivariable analyses, only PSA 4 ng/ml (HR: 2.13; p = 0.03) and the presence of retroperitoneal uptake at PET/CT scan (HR = 2.92; p = 0.004) represented independent preoperative predictors of CR. Similarly, the presence of pathologic nodes in the retroperitoneum (HR: 2.78; p = 0.02), higher number of positive lymph nodes (HR: 1.04; p = 0.006), and complete BR to salvage LND (HR: 0.31; p = 0.002) represented postoperative independent predictors of CR. Main limitations consisted of the lack of a control group and the heterogeneity of patients included in the analyses. Conclusions: Salvage LND is feasible in patients with BCR after RP and nodal pathologic uptake at [11C]choline PET/CT scan. Biochemical response after surgery can be achieved in a consistent proportion of patients. Although most patients invariably progressed to BCR after surgery at longer follow-up, 35% of patients showed the absence of CR at 5 yr. JF - European Urology AU - Rigatti, Patrizio AU - Suardi, Nazareno AU - Briganti, Alberto AU - Pozzo, Luigi FDa AU - Tutolo, Manuela AU - Villa, Luca AU - Gallina, Andrea AU - Capitanio, Umberto AU - Abdollah, Firas AU - Scattoni, Vincenzo AU - Colombo, Renzo AU - Freschi, Massimo AU - Picchio, Maria AU - Messa, Cristina AU - Guazzoni, Giorgio AU - Montorsi, Francesco AD - Department of Urology, Urological Research Institute, University Vita-Salute San Raffaele, Milan, Italy, suardi.nazareno@hsr.it Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 935 EP - 943 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 60 IS - 5 SN - 0302-2838, 0302-2838 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Lymph nodes KW - Pelvis KW - Positron emission tomography KW - Prognosis KW - Prostate cancer KW - Regression analysis KW - Retroperitoneum KW - Surgery KW - Survival KW - prostate-specific antigen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238122552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Urology&rft.atitle=Pelvic%2FRetroperitoneal+Salvage+Lymph+Node+Dissection+for+Patients+Treated+With+Radical+Prostatectomy+With+Biochemical+Recurrence+and+Nodal+Recurrence+Detected+by+%5B11C%5DCholine+Positron+Emission+Tomography%2FComputed+Tomography&rft.au=Rigatti%2C+Patrizio%3BSuardi%2C+Nazareno%3BBriganti%2C+Alberto%3BPozzo%2C+Luigi+FDa%3BTutolo%2C+Manuela%3BVilla%2C+Luca%3BGallina%2C+Andrea%3BCapitanio%2C+Umberto%3BAbdollah%2C+Firas%3BScattoni%2C+Vincenzo%3BColombo%2C+Renzo%3BFreschi%2C+Massimo%3BPicchio%2C+Maria%3BMessa%2C+Cristina%3BGuazzoni%2C+Giorgio%3BMontorsi%2C+Francesco&rft.aulast=Rigatti&rft.aufirst=Patrizio&rft.date=2011-11-01&rft.volume=60&rft.issue=5&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=European+Urology&rft.issn=03022838&rft_id=info:doi/10.1016%2Fj.eururo.2011.07.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-28 N1 - SubjectsTermNotLitGenreText - Pelvis; Prostate cancer; Surgery; Computed tomography; Prognosis; Regression analysis; Positron emission tomography; Survival; prostate-specific antigen; Lymph nodes; Retroperitoneum DO - http://dx.doi.org/10.1016/j.eururo.2011.07.060 ER - TY - JOUR T1 - Achieving the Goals of the National HIV/AIDS Strategy: Keeping Gender in Mind AN - 1081897116; 201225410 AB - The vision of the National HIV/AIDS Strategy released in 2010 is discussed. Part of a special journal issue on the subject, 'Bringing Gender Home: Implementing Gender-Responsive HIV/AIDS Programming for U.S. Women and Girls', the result of a 2-day meeting in 2010, a partnership with UNAIDS and the U.S. Office on Women's Health aimed at promoting 'increased leadership in gender-responsive programming for women and girls.'. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Yakovchenko, Vera AU - Valdiserri, Ronald O AD - Office of HIV/AIDS Policy, Office of the Assistant Secretary for Health, U.S. Department of Health and Human Services, 200 Independence Ave S.W. Room 443H, Washington, DC 20201. Phone: 202-205-6606; Fax: 202-690-7560 Y1 - 2011/11// PY - 2011 DA - November 2011 SP - S237 EP - S238 PB - Elsevier Science, New York NY VL - 21 IS - 6s SN - 1049-3867, 1049-3867 KW - Girls KW - Gender KW - Women KW - Women's issues KW - HIV KW - Leadership KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081897116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Achieving+the+Goals+of+the+National+HIV%2FAIDS+Strategy%3A+Keeping+Gender+in+Mind&rft.au=Yakovchenko%2C+Vera%3BValdiserri%2C+Ronald+O&rft.aulast=Yakovchenko&rft.aufirst=Vera&rft.date=2011-11-01&rft.volume=21&rft.issue=6s&rft.spage=S237&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - HIV; Women; Girls; Gender; Leadership; Women's issues DO - http://dx.doi.org/10.1016/j.whi.2011.04.016 ER - TY - JOUR T1 - Veterinary Public Health Capacity in the United States: Opportunities for Improvement AN - 1030886245; 2011-233423 AB - Objectives. In 2006, the Association of American Veterinary Medical Colleges reported that the shortage (under 1,500) of public health veterinarians is expected to increase tenfold by 2020. In 2008, the Centers for Disease Control and Prevention (CDC) Preventive Medicine Fellows conducted a pilot project among CDC veterinarians to identify national veterinary public health workforce concerns and potential policy strategies. Methods. Fellows surveyed a convenience sample (19/91) of public health veterinarians at CDC to identify veterinary workforce recruitment and retention problems faced by federal agencies; responses were categorized into themes. A focus group (20/91) of staff veterinarians subsequently prioritized the categorized themes from least to most important. Participants identified activities to address the three recruitment concerns with the highest combined weight. Results. Participants identified the following three highest prioritized problems faced by federal agencies when recruiting veterinarians to public health: (1) lack of awareness of veterinarians' contributions to public health practice, (2) competitive salaries, and (3) employment and training opportunities. Similarly, key concerns identified regarding retention of public health practice veterinarians included: (1) lack of recognition of veterinary qualifications, (2) competitive salaries, and (3) seamless integration of veterinary and human public health. Conclusions. Findings identified multiple barriers that can affect recruitment and retention of veterinarians engaged in public health practice. Next steps should include replicating project efforts among a national sample of public health veterinarians. A committed and determined long-term effort might be required to sustain initiatives and policy proposals to increase U.S. veterinary public health capacity. Adapted from the source document. JF - Public Health Reports AU - Jarman, Dwayne W AU - Liang, Jennifer L AU - Luce, Richard R AU - Wright, Jennifer G AU - Stennies, Gail M AU - Bisgard, Kristine M AD - U.S. Food and Drug Administration, Office of Regulatory Affairs dwayne.jarman@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 868 EP - 874 PB - Association of Schools of Public Health, Washington DC VL - 126 IS - 6 SN - 0033-3549, 0033-3549 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Diseases and disorders KW - Labor conditions and policy - Employment and labor supply KW - Social conditions and policy - Associations and meetings KW - United States KW - Public health education KW - Associations KW - Medicine KW - Employment KW - Diseases KW - Qualifications KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030886245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Veterinary+Public+Health+Capacity+in+the+United+States%3A+Opportunities+for+Improvement&rft.au=Jarman%2C+Dwayne+W%3BLiang%2C+Jennifer+L%3BLuce%2C+Richard+R%3BWright%2C+Jennifer+G%3BStennies%2C+Gail+M%3BBisgard%2C+Kristine+M&rft.aulast=Jarman&rft.aufirst=Dwayne&rft.date=2011-11-01&rft.volume=126&rft.issue=6&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Public health education; Diseases; Medicine; United States; Employment; Associations; Qualifications ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF [alpha],[Beta]-THUJONE (CAS NO. 76231-76-0) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 1011582003; 22127327 AB - α,β-Thujone is a component of the essential oils of some plants including wormwood, sage, and cedar. It is used in herbal medicines, food and flavoring, and notably as the principal ingredient of the liqueur absinthe. We studied the effects of α,β-thujone on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing α,β-thujone in methylcellulose through a tube directly into the stomach to groups of 50 male and female rats and mice five days per week for two years. Exposed rats received either 12.5, 25, or 50 milligrams of α,β-thujone per kilogram of body weight, and mice received 3, 6, 12, or 25 mg/kg. Control animals received methylcellulose with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. All male and female rats receiving 50 mg/kg α,β-thujone died before the end of the study. All of those animals, and most receiving 25 mg/kg, experienced seizures. In male rats there was an increased incidence of cancers of the preputial gland and a slight increase in the incidence of pheochromocytomas of the adrenal gland. Nearly all male and female mice receiving 25 mg/kg α,β-thujone experienced seizures, and all of the female mice receiving 25 mg/kg died before the end of the study. No increases in cancers were observed in female rats or in male or female mice. We conclude that α,β-thujone caused cancers of the preputial gland in male rats, and an increase in adrenal gland tumors in male rats may have been related to α,β-thujone administration. There was no increase in cancer incidence in female rats or male or female mice. Seizures were seen in almost all rats and mice receiving the highest doses of α,β-thujone. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1 EP - 260 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Monoterpenes KW - Mutagens KW - beta-thujone KW - Cancer KW - Food additives KW - Toxicity KW - Human exposure KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Seizures -- chemically induced KW - Monoterpenes -- toxicity KW - Pheochromocytoma -- chemically induced KW - Adrenal Gland Neoplasms -- chemically induced KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011582003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+%5Balpha%5D%2C%5BBeta%5D-THUJONE+%28CAS+NO.+76231-76-0%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Document feature - Tables; References; Graphs; Diagrams N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - ERRATUM AN - 1011477061 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 261 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=ERRATUM&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1011477060 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1011477059 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - CPAPER T1 - Federal Perspective on the MCH Workforce T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313017707; 6051561 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kavanagh, Laura Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Perspective+on+the+MCH+Workforce&rft.au=Kavanagh%2C+Laura&rft.aulast=Kavanagh&rft.aufirst=Laura&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Latino Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015987; 6049202 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mora, Sonia Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Latino+Communities+Working+to+Achieve+Better+Health&rft.au=Mora%2C+Sonia&rft.aulast=Mora&rft.aufirst=Sonia&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Asian American Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015737; 6049201 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chan, Chun Man Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Social aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Asian+American+Communities+Working+to+Achieve+Better+Health&rft.au=Chan%2C+Chun+Man&rft.aulast=Chan&rft.aufirst=Chun&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - African American Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015678; 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6049573 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Choi, Colleen AU - Hua, Jiaying AU - Erlandson, Diane AU - Monickam, Sarah AU - West, William Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Health care KW - Data banks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313013475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+Querying+and+Reporting+to+the+National+Practitioner+Data+Bank+and+the+Healthcare+Integrity+Protection+Data+Bank&rft.au=Choi%2C+Colleen%3BHua%2C+Jiaying%3BErlandson%2C+Diane%3BMonickam%2C+Sarah%3BWest%2C+William&rft.aulast=Choi&rft.aufirst=Colleen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - International recruitment of health workers: A view from the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313011792; 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6048908 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Paxman, Dalton Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Heaths UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Viewing+heath+improvement+through+a+regional+and+local+lens&rft.au=Paxman%2C+Dalton&rft.aulast=Paxman&rft.aufirst=Dalton&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Healthy People 2020: Prevention roadmap to better health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313007075; 6048907 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Blakey, Carter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prevention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Prevention+roadmap+to+better+health&rft.au=Blakey%2C+Carter&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Application of IVD Testing in Therapeutic Trials T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006234; 6051085 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mansfield, Elizabeth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Application+of+IVD+Testing+in+Therapeutic+Trials&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Progress Moving Forward with the National Partnership for Action T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006162; 6048939 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Graham, Garth AU - Rollins, Rochelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Progress+Moving+Forward+with+the+National+Partnership+for+Action&rft.au=Graham%2C+Garth%3BRollins%2C+Rochelle&rft.aulast=Graham&rft.aufirst=Garth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hepatitis B in the Asian-American Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313005212; 6048633 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Brickham, Tamara AU - Hsu, Chiehwen AU - Yang, Shiou- Bih AU - Shen, Whey AU - Chen, Shane AU - Ajani, Shahnaz AU - Turner, Cynthia AU - McNeese-Ward, Marlene Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - hepatitis B KW - Hepatitis B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Hepatitis+B+in+the+Asian-American+Community&rft.au=Brickham%2C+Tamara%3BHsu%2C+Chiehwen%3BYang%2C+Shiou-+Bih%3BShen%2C+Whey%3BChen%2C+Shane%3BAjani%2C+Shahnaz%3BTurner%2C+Cynthia%3BMcNeese-Ward%2C+Marlene&rft.aulast=Brickham&rft.aufirst=Tamara&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Health IT and Disparities, Relevant Federal Initiatives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313002394; 6050134 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gerdine, Miryam Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313002394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Health+IT+and+Disparities%2C+Relevant+Federal+Initiatives&rft.au=Gerdine%2C+Miryam&rft.aulast=Gerdine&rft.aufirst=Miryam&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Utilization of electronic field medical surveillance in international disaster response; an assessment of data utility in the 2010 Haiti Earthquake T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313001775; 6051258 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Passman, Dina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Caribbean Sea, Greater Antilles, Haiti KW - Earthquakes KW - Seismic activity KW - Disasters KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313001775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Utilization+of+electronic+field+medical+surveillance+in+international+disaster+response%3B+an+assessment+of+data+utility+in+the+2010+Haiti+Earthquake&rft.au=Passman%2C+Dina&rft.aulast=Passman&rft.aufirst=Dina&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Faces of Black Lung T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312998673; 6050323 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wolfe, Anita AU - Petsonk, Edward AU - Urban, Charles Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Lung KW - Black lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Faces+of+Black+Lung&rft.au=Wolfe%2C+Anita%3BPetsonk%2C+Edward%3BUrban%2C+Charles&rft.aulast=Wolfe&rft.aufirst=Anita&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Addressing Racial/Ethnic Disparities in Cancer Screenings Among Health Center Patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997937; 6051297 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ngo-Metzger, Quyen Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Cancer KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Addressing+Racial%2FEthnic+Disparities+in+Cancer+Screenings+Among+Health+Center+Patients&rft.au=Ngo-Metzger%2C+Quyen&rft.aulast=Ngo-Metzger&rft.aufirst=Quyen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Reducing Disparities in Access to Primary Care and Patient Satisfaction: The Role of Health Centers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997684; 6051295 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lebrun, Lydie Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Reducing+Disparities+in+Access+to+Primary+Care+and+Patient+Satisfaction%3A+The+Role+of+Health+Centers&rft.au=Lebrun%2C+Lydie&rft.aulast=Lebrun&rft.aufirst=Lydie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Implementation Model for CLASS Act T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997201; 6049992 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wren, John Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Implementation+Model+for+CLASS+Act&rft.au=Wren%2C+John&rft.aulast=Wren&rft.aufirst=John&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bright Futures for Women's Health and Wellness (BFWHW) Initiative - Emotional Wellness Consumer Tools Evaluation & Findings T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312996679; 6051869 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rice, Morrisa AU - Mehta, Shalini Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Emotions KW - Consumers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Bright+Futures+for+Women%27s+Health+and+Wellness+%28BFWHW%29+Initiative+-+Emotional+Wellness+Consumer+Tools+Evaluation+%26amp%3B+Findings&rft.au=Rice%2C+Morrisa%3BMehta%2C+Shalini&rft.aulast=Rice&rft.aufirst=Morrisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Putting the Public Health into Mental Health: Screening Children and Adolescents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995454; 6048448 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rubenstein, Lisa AU - Lulow, Eric AU - Jensen, Peter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Adolescents KW - Public health KW - Children KW - Mental disorders KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Putting+the+Public+Health+into+Mental+Health%3A+Screening+Children+and+Adolescents&rft.au=Rubenstein%2C+Lisa%3BLulow%2C+Eric%3BJensen%2C+Peter&rft.aulast=Rubenstein&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Developing standard case definitions of newborn screening disorders for epidemiological surveillance T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995019; 6051759 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Sarkar, Deboshree AU - Copeland, Sara Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Neonates KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Developing+standard+case+definitions+of+newborn+screening+disorders+for+epidemiological+surveillance&rft.au=Sarkar%2C+Deboshree%3BCopeland%2C+Sara&rft.aulast=Sarkar&rft.aufirst=Deboshree&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - CHCs, MU, & PCMH: An Alphabet Soup that Translates into Patient-Centered, High Quality Health Care for the Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992810; 6048382 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Harris, Yael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Health care KW - Soups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=CHCs%2C+MU%2C+%26amp%3B+PCMH%3A+An+Alphabet+Soup+that+Translates+into+Patient-Centered%2C+High+Quality+Health+Care+for+the+Community&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Modifying the behavior of food employees using training materials and methods designed for oral culture learners T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992569; 6051199 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pittman, JoAnn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Training KW - Education KW - Food KW - Personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Modifying+the+behavior+of+food+employees+using+training+materials+and+methods+designed+for+oral+culture+learners&rft.au=Pittman%2C+JoAnn&rft.aulast=Pittman&rft.aufirst=JoAnn&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Evaluation Strategy for the Teen Pregnancy Prevention Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312990712; 6050808 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Trivits, Lisa AU - Chamberlain, Seth AU - Margolis, Amy AU - Tevendale, Heather AU - Tyson, Diana AU - Hershey, Alan AU - Kelsey, Meredith AU - Knab, Jean AU - Layzer, Jean AU - Trenholm, Chris AU - Goerlich Zief, Susan Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prevention KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312990712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Evaluation+Strategy+for+the+Teen+Pregnancy+Prevention+Program&rft.au=Trivits%2C+Lisa%3BChamberlain%2C+Seth%3BMargolis%2C+Amy%3BTevendale%2C+Heather%3BTyson%2C+Diana%3BHershey%2C+Alan%3BKelsey%2C+Meredith%3BKnab%2C+Jean%3BLayzer%2C+Jean%3BTrenholm%2C+Chris%3BGoerlich+Zief%2C+Susan&rft.aulast=Trivits&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Protecting and Promoting the Total Health of Workers: Keys to a Healthier, Safer and More Engaged Workforce T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312989078; 6051818 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Nigam, Jeannie AU - Schill, Anita Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Keys KW - Workers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312989078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Protecting+and+Promoting+the+Total+Health+of+Workers%3A+Keys+to+a+Healthier%2C+Safer+and+More+Engaged+Workforce&rft.au=Nigam%2C+Jeannie%3BSchill%2C+Anita&rft.aulast=Nigam&rft.aufirst=Jeannie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Utilizing prenatal screening, social networking, and community partnerships to conduct investigations: A unique public health cluster T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312987663; 6049592 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hines Jr, Robert AU - Sackett, Shawta AU - Doty, Virginia AU - Chronister, Karen AU - McNeese-Ward, Marlene Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - prenatal experience KW - networking KW - Social organization KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312987663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Utilizing+prenatal+screening%2C+social+networking%2C+and+community+partnerships+to+conduct+investigations%3A+A+unique+public+health+cluster&rft.au=Hines+Jr%2C+Robert%3BSackett%2C+Shawta%3BDoty%2C+Virginia%3BChronister%2C+Karen%3BMcNeese-Ward%2C+Marlene&rft.aulast=Hines+Jr&rft.aufirst=Robert&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National Efforts to Increase Integration of Oral Health into School Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312986918; 6049070 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Vodicka, Pamella Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - schools KW - Integration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+Efforts+to+Increase+Integration+of+Oral+Health+into+School+Health&rft.au=Vodicka%2C+Pamella&rft.aulast=Vodicka&rft.aufirst=Pamella&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Patient safety collaborative: Rapid-cycle implementation of safe medication practices in communities nationwide T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312986809; 6049039 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lai, Eric AU - Kwon, Linda AU - Williams, Karen Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Patient+safety+collaborative%3A+Rapid-cycle+implementation+of+safe+medication+practices+in+communities+nationwide&rft.au=Lai%2C+Eric%3BKwon%2C+Linda%3BWilliams%2C+Karen&rft.aulast=Lai&rft.aufirst=Eric&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of adult blood lead levels below 25 mcg/dL in the New Hampshire Adult Blood Lead Epidemiology and Surveillance Program (ABLES) Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312984912; 6051581 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Armenti, Karla AU - Allison, Suzanne AU - Caron, Rosemary AU - Lakevicius, Paul AU - Foley, Tim Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA, New Hampshire KW - Blood levels KW - Epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Characterization+of+adult+blood+lead+levels+below+25+mcg%2FdL+in+the+New+Hampshire+Adult+Blood+Lead+Epidemiology+and+Surveillance+Program+%28ABLES%29+Program&rft.au=Armenti%2C+Karla%3BAllison%2C+Suzanne%3BCaron%2C+Rosemary%3BLakevicius%2C+Paul%3BFoley%2C+Tim&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Successful Implementation of PrEP within the National HIV/AIDS Strategy T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312983819; 6050732 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Valdiserri, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Successful+Implementation+of+PrEP+within+the+National+HIV%2FAIDS+Strategy&rft.au=Valdiserri%2C+Ronald&rft.aulast=Valdiserri&rft.aufirst=Ronald&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Importance of community engagement in the movement to eliminate hepatitis B disparities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312980632; 6050344 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chan, Chun Man Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - hepatitis B KW - community involvement KW - Hepatitis B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312980632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Importance+of+community+engagement+in+the+movement+to+eliminate+hepatitis+B+disparities&rft.au=Chan%2C+Chun+Man&rft.aulast=Chan&rft.aufirst=Chun&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - OMH's Role in the HHS Oral Health Initiative T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312980535; 6051828 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rollins, Rochelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312980535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=OMH%27s+Role+in+the+HHS+Oral+Health+Initiative&rft.au=Rollins%2C+Rochelle&rft.aulast=Rollins&rft.aufirst=Rochelle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Population-based surveillance for methicillin-resistant Staphylococcus aureus infections among high school football and wrestling participants--Nebraska, 2008-2010 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312978855; 6048953 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Buss, Bryan AU - Safranek, Thomas Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - infection KW - antibiotic resistance KW - Infection KW - Drug resistance KW - Staphylococcus aureus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312978855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Population-based+surveillance+for+methicillin-resistant+Staphylococcus+aureus+infections+among+high+school+football+and+wrestling+participants--Nebraska%2C+2008-2010&rft.au=Buss%2C+Bryan%3BSafranek%2C+Thomas&rft.aulast=Buss&rft.aufirst=Bryan&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Cultural and Linguistic Competency Resource Center to Facilitate the Elimination of Health Inequities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312977114; 6051284 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - culture KW - Language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=A+Cultural+and+Linguistic+Competency+Resource+Center+to+Facilitate+the+Elimination+of+Health+Inequities&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Health Policy Making: Clinician Turned Wonk T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976117; 6048891 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Margolis, Gregg Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - health policy KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Health+Policy+Making%3A+Clinician+Turned+Wonk&rft.au=Margolis%2C+Gregg&rft.aulast=Margolis&rft.aufirst=Gregg&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bringing scientific, clinical and public health expertise to the policy process T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976080; 6048890 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kaplowitz, Lisa Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Bringing+scientific%2C+clinical+and+public+health+expertise+to+the+policy+process&rft.au=Kaplowitz%2C+Lisa&rft.aulast=Kaplowitz&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using the principles of health literacy to drive positive dietary behavior change T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975777; 6048984 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Butner, Katrina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Diets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Using+the+principles+of+health+literacy+to+drive+positive+dietary+behavior+change&rft.au=Butner%2C+Katrina&rft.aulast=Butner&rft.aufirst=Katrina&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Electronic Health Record: Implications for Occupational Safety and Health Surveillance T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975222; 6048775 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Souza, Kerry AU - Storey, Eileen AU - Filios, Margaret Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Occupational safety KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Electronic+Health+Record%3A+Implications+for+Occupational+Safety+and+Health+Surveillance&rft.au=Souza%2C+Kerry%3BStorey%2C+Eileen%3BFilios%2C+Margaret&rft.aulast=Souza&rft.aufirst=Kerry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National Release of the Leading Health Indicators from Healthy People 2020 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312974596; 6048595 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Koh, Howard Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+Release+of+the+Leading+Health+Indicators+from+Healthy+People+2020&rft.au=Koh%2C+Howard&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Prevalence and correlates of having serious thoughts of suicide in the past year among community-dwelling adults in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312972324; 6050511 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Han, Beth AU - Barker, Peggy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - suicide KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312972324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Prevalence+and+correlates+of+having+serious+thoughts+of+suicide+in+the+past+year+among+community-dwelling+adults+in+the+United+States&rft.au=Han%2C+Beth%3BBarker%2C+Peggy&rft.aulast=Han&rft.aufirst=Beth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building a Health IT Workforce To Meet the Needs of Underserved Communities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312971262; 6049333 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Harris, Yael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312971262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+a+Health+IT+Workforce+To+Meet+the+Needs+of+Underserved+Communities&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Fostering healthy Tribal communities: Developing a model for Tribal advocacy for HIV/AIDS prevention, education, and testing T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968485; 6049827 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bennett-Barnes, Evonne Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Human immunodeficiency virus KW - prevention KW - Education KW - Acquired immune deficiency syndrome KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Fostering+healthy+Tribal+communities%3A+Developing+a+model+for+Tribal+advocacy+for+HIV%2FAIDS+prevention%2C+education%2C+and+testing&rft.au=Bennett-Barnes%2C+Evonne&rft.aulast=Bennett-Barnes&rft.aufirst=Evonne&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Healthy People 2020: Target setting for the dietary intake objectives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968421; 6050699 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Juan, WenYen AU - Crane, Nancy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ingestion KW - Diets KW - Dietary intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Target+setting+for+the+dietary+intake+objectives&rft.au=Juan%2C+WenYen%3BCrane%2C+Nancy&rft.aulast=Juan&rft.aufirst=WenYen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Community Health Applied Research Network: A marriage of community health centers with academic health centers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967745; 6050721 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Felix, Kaytura Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - marriage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Community+Health+Applied+Research+Network%3A+A+marriage+of+community+health+centers+with+academic+health+centers&rft.au=Felix%2C+Kaytura&rft.aulast=Felix&rft.aufirst=Kaytura&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Trends in Disparities in Healthcare Associated Infections T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967644; 6050718 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Moy, Ernest Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - infection KW - Health care KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+Disparities+in+Healthcare+Associated+Infections&rft.au=Moy%2C+Ernest&rft.aulast=Moy&rft.aufirst=Ernest&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Racial/Ethnic Patterns of Illicit Drug Use Disorders among Adolescents and Adults in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967493; 6051654 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Muhuri, Pradip Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Adolescents KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Racial%2FEthnic+Patterns+of+Illicit+Drug+Use+Disorders+among+Adolescents+and+Adults+in+the+United+States&rft.au=Muhuri%2C+Pradip&rft.aulast=Muhuri&rft.aufirst=Pradip&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Asbestosis and Malignant Mesothelioma Mortality in the United States: An update T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967127; 6051586 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bang, Ki AU - Mazurek, Jacek AU - Wassell, James AU - Wood, John AU - Syamlal, Girija Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Mortality KW - mesothelioma KW - Asbestosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Asbestosis+and+Malignant+Mesothelioma+Mortality+in+the+United+States%3A+An+update&rft.au=Bang%2C+Ki%3BMazurek%2C+Jacek%3BWassell%2C+James%3BWood%2C+John%3BSyamlal%2C+Girija&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integrating and evaluating social media as a part of your communications package: The honeymoon is over T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312964965; 6049065 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Burnett, Garrett Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication KW - Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Integrating+and+evaluating+social+media+as+a+part+of+your+communications+package%3A+The+honeymoon+is+over&rft.au=Burnett%2C+Garrett&rft.aulast=Burnett&rft.aufirst=Garrett&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Lessons Learned at NIOSH: Using the Tools of Social Media to Build our Community of Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312964926; 6049064 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lum, Max Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Lessons+Learned+at+NIOSH%3A+Using+the+Tools+of+Social+Media+to+Build+our+Community+of+Practice&rft.au=Lum%2C+Max&rft.aulast=Lum&rft.aufirst=Max&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Behavioral Health Statistics: Using Data from the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Behavioral Health Statistics and Quality in Public Behavioral Health Surveillance, Policy Making, and Planning T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312963171; 6048531 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Smith, Kelley AU - Delany, Peter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - substance abuse KW - Statistics KW - Data processing KW - Mental disorders KW - Drug abuse KW - Public health KW - Policies KW - National planning KW - Biological surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312963171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Behavioral+Health+Statistics%3A+Using+Data+from+the+Substance+Abuse+and+Mental+Health+Services+Administration%27s+%28SAMHSA%29+Center+for+Behavioral+Health+Statistics+and+Quality+in+Public+Behavioral+Health+Surveillance%2C+Policy+Making%2C+and+Planning&rft.au=Smith%2C+Kelley%3BDelany%2C+Peter&rft.aulast=Smith&rft.aufirst=Kelley&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - An innovative approach to promoting equity and addressing disparities: The National Network to Eliminate Disparities in Behavioral Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312963129; 6048799 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Huang, Larke AU - Dutta, Trina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312963129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=An+innovative+approach+to+promoting+equity+and+addressing+disparities%3A+The+National+Network+to+Eliminate+Disparities+in+Behavioral+Health&rft.au=Huang%2C+Larke%3BDutta%2C+Trina&rft.aulast=Huang&rft.aufirst=Larke&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - How the HHS HAI NAP is Morphing into the Partnership for Patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962885; 6049324 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Battles, James Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=How+the+HHS+HAI+NAP+is+Morphing+into+the+Partnership+for+Patients&rft.au=Battles%2C+James&rft.aulast=Battles&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Understanding Health Promotion in the African American Church T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962663; 6050357 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Tilson, Wilma Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Africa KW - health promotion KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Understanding+Health+Promotion+in+the+African+American+Church&rft.au=Tilson%2C+Wilma&rft.aulast=Tilson&rft.aufirst=Wilma&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Black and white rates of low birth weight, preterm birth, and infant mortality by state and county: A mid-decade evaluation of progress toward Healthy People 2010 objectives and the goal of disparity elimination T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962026; 6051801 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Schempf, Ashley AU - Kramer, Michael AU - Ghandour, Reem AU - Mendola, Pauline AU - Schoendorf, Kenneth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - low-birth-weight KW - infant mortality KW - Pregnancy KW - Birth weight KW - Mortality KW - Infants KW - Parturition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Black+and+white+rates+of+low+birth+weight%2C+preterm+birth%2C+and+infant+mortality+by+state+and+county%3A+A+mid-decade+evaluation+of+progress+toward+Healthy+People+2010+objectives+and+the+goal+of+disparity+elimination&rft.au=Schempf%2C+Ashley%3BKramer%2C+Michael%3BGhandour%2C+Reem%3BMendola%2C+Pauline%3BSchoendorf%2C+Kenneth&rft.aulast=Schempf&rft.aufirst=Ashley&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Intervention Dimensions: Building a sustainable school based program and study to improve family disaster preparedness actions T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312961105; 6051370 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gilmore, Melanie AU - Foreman, Faith AU - Obregon, Misael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Emergency preparedness KW - Sustainable development KW - intervention KW - schools KW - Disasters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Intervention+Dimensions%3A+Building+a+sustainable+school+based+program+and+study+to+improve+family+disaster+preparedness+actions&rft.au=Gilmore%2C+Melanie%3BForeman%2C+Faith%3BObregon%2C+Misael&rft.aulast=Gilmore&rft.aufirst=Melanie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Leadership Development for Community Health Improvement - KPHLI Experience T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312955562; 6049703 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Srinivasan, Jayaram Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Leadership+Development+for+Community+Health+Improvement+-+KPHLI+Experience&rft.au=Srinivasan%2C+Jayaram&rft.aulast=Srinivasan&rft.aufirst=Jayaram&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National CLAS Standards Enhancement Initiative: An HHS Office of Minority Health Initiative to Advance Culturally and Linguistically Appropriate Health Services T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312954258; 6051052 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312954258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+CLAS+Standards+Enhancement+Initiative%3A+An+HHS+Office+of+Minority+Health+Initiative+to+Advance+Culturally+and+Linguistically+Appropriate+Health+Services&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Show Me How T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312944294; 6050600 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bechard, Michelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312944294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Show+Me+How&rft.au=Bechard%2C+Michelle&rft.aulast=Bechard&rft.aufirst=Michelle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Trends in prevalence and incidence of and factors associated with nonmedical use of prescription pain relievers among adults aged 50 or older in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312942772; 6049682 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Han, Beth AU - Gfroerer, Joe Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - pain KW - Pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312942772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+prevalence+and+incidence+of+and+factors+associated+with+nonmedical+use+of+prescription+pain+relievers+among+adults+aged+50+or+older+in+the+United+States&rft.au=Han%2C+Beth%3BGfroerer%2C+Joe&rft.aulast=Han&rft.aufirst=Beth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Social Media Strategy at AIDS.gov T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312940854; 6049514 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gomez, Miguel Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312940854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Social+Media+Strategy+at+AIDS.gov&rft.au=Gomez%2C+Miguel&rft.aulast=Gomez&rft.aufirst=Miguel&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of Patient Navigators as a Strategy to Increase Access to Care for Health Disparities Populations T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312937424; 6048761 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Peplinski, Kyle AU - McLeod, Caroline AU - Stark, Debra Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312937424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Use+of+Patient+Navigators+as+a+Strategy+to+Increase+Access+to+Care+for+Health+Disparities+Populations&rft.au=Peplinski%2C+Kyle%3BMcLeod%2C+Caroline%3BStark%2C+Debra&rft.aulast=Peplinski&rft.aufirst=Kyle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Occupational Surveillance of Young U.S. Workers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312924505; 6050037 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hollenbeck, Julie AU - Caban-Martinez, Alberto AU - Fleming, Lora AU - LeBlanc, William AU - Christ, Sharon AU - Clarke, Tainya AU - Kachan, Diana AU - McCollister, Katherine AU - Arheart, Kristopher AU - Goodman, Elizabeth AU - Zimmerman, Frederick AU - Muntaner, Carles AU - Lee, David Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Workers KW - Surveillance and enforcement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312924505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Occupational+Surveillance+of+Young+U.S.+Workers&rft.au=Hollenbeck%2C+Julie%3BCaban-Martinez%2C+Alberto%3BFleming%2C+Lora%3BLeBlanc%2C+William%3BChrist%2C+Sharon%3BClarke%2C+Tainya%3BKachan%2C+Diana%3BMcCollister%2C+Katherine%3BArheart%2C+Kristopher%3BGoodman%2C+Elizabeth%3BZimmerman%2C+Frederick%3BMuntaner%2C+Carles%3BLee%2C+David&rft.aulast=Hollenbeck&rft.aufirst=Julie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - HRSA Perspective and the IOM Oral Health Reports T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312923420; 6049620 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Adirim, Terry Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=HRSA+Perspective+and+the+IOM+Oral+Health+Reports&rft.au=Adirim%2C+Terry&rft.aulast=Adirim&rft.aufirst=Terry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building Healthy Communities: The National CLAS Standards Enhancement Initiative to Advance Health Equity at Every Point of Contact T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312923060; 6049556 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+Healthy+Communities%3A+The+National+CLAS+Standards+Enhancement+Initiative+to+Advance+Health+Equity+at+Every+Point+of+Contact&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Medicare hospices that focus on nursing facility residents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312922932; 6048862 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Nudelman, Jodi AU - Seife, Meridith AU - Harrison, Nancy AU - Herman, Olivia AU - Goldberg, Rose AU - Rubin, Michael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312922932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Medicare+hospices+that+focus+on+nursing+facility+residents&rft.au=Nudelman%2C+Jodi%3BSeife%2C+Meridith%3BHarrison%2C+Nancy%3BHerman%2C+Olivia%3BGoldberg%2C+Rose%3BRubin%2C+Michael&rft.aulast=Nudelman&rft.aufirst=Jodi&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - BodyWorks: Evaluating both parent and adolescent involvement in a family-based, healthy lifestyle program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312921467; 6049102 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Abercrombie, R AU - Fishman, Jodie AU - Book, Amanda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312921467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=BodyWorks%3A+Evaluating+both+parent+and+adolescent+involvement+in+a+family-based%2C+healthy+lifestyle+program&rft.au=Abercrombie%2C+R%3BFishman%2C+Jodie%3BBook%2C+Amanda&rft.aulast=Abercrombie&rft.aufirst=R&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Domestic and international efforts in mental health by the National Institute of Mental Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312906977; 6051431 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Collins, Pamela Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Domestic+and+international+efforts+in+mental+health+by+the+National+Institute+of+Mental+Health&rft.au=Collins%2C+Pamela&rft.aulast=Collins&rft.aufirst=Pamela&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Public Health Quality: A National Framework and Criteria to Aid in Selecting Community Benefit and Community Building Activities that Improve Community Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312905617; 6051121 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Honore, Peggy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Public+Health+Quality%3A+A+National+Framework+and+Criteria+to+Aid+in+Selecting+Community+Benefit+and+Community+Building+Activities+that+Improve+Community+Health&rft.au=Honore%2C+Peggy&rft.aulast=Honore&rft.aufirst=Peggy&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Improving Health Literacy at All Levels: The National Action Plan to Improve Health Literacy and Healthy People 2020 Health Communication and Health IT Objectives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312903554; 6050386 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rowden, Jessica Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312903554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Improving+Health+Literacy+at+All+Levels%3A+The+National+Action+Plan+to+Improve+Health+Literacy+and+Healthy+People+2020+Health+Communication+and+Health+IT+Objectives&rft.au=Rowden%2C+Jessica&rft.aulast=Rowden&rft.aufirst=Jessica&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quality by Design for DPIs -A Regulatory Perspective T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313033904; 6080161 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Peri, Prasad Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Chemical engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313033904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Quality+by+Design+for+DPIs+-A+Regulatory+Perspective&rft.au=Peri%2C+Prasad&rft.aulast=Peri&rft.aufirst=Prasad&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quality by Design (QbD) Opportunities, Challenges and Future Direction T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313024885; 6080080 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Nasr, Moheb Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Chemical engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313024885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Quality+by+Design+%28QbD%29+Opportunities%2C+Challenges+and+Future+Direction&rft.au=Nasr%2C+Moheb&rft.aulast=Nasr&rft.aufirst=Moheb&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Challenges, Opportunities, and Scientific Aspects of Implementing PAT In Biopharmaceuticals T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313022761; 6080153 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313022761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Challenges%2C+Opportunities%2C+and+Scientific+Aspects+of+Implementing+PAT+In+Biopharmaceuticals&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation AN - 1221142638; 15747062 AB - Advances in predicting in vivo performance of drug products has the potential to change how drug products are developed and reviewed. Modeling and simulation methods are now more commonly used in drug product development and regulatory drug review. These applications include, but are not limited to: the development of biorelevant specifications, the determination of bioequivalence metrics for modified release products with rapid therapeutic onset, the design of in vitro-in vivo correlations in a mechanistic framework, and prediction of food effect. As new regulatory concepts such as quality by design require better application of biopharmaceutical modeling in drug product development, regulatory challenges in bioequivalence demonstration of complex drug products also present exciting opportunities for creative modeling and simulation approaches. A collaborative effort among academia, government and industry in modeling and simulation will result in improved safe and effective new/generic drugs to the American public. JF - International Journal of Pharmaceutics AU - Jiang, Wenlei AU - Kim, Stephanie AU - Zhang, Xinyuan AU - Lionberger, Robert A AU - Davit, Barbara M AU - Conner, Dale P AU - Yu, Lawrence X Y1 - 2011/10/14/ PY - 2011 DA - 2011 Oct 14 SP - 151 EP - 160 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 418 IS - 2 SN - 0378-5173, 0378-5173 KW - Biotechnology and Bioengineering Abstracts KW - Development KW - Drug development KW - Drugs KW - Food KW - Pharmaceuticals KW - Reviews KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221142638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Pharmaceutics&rft.atitle=The+role+of+predictive+biopharmaceutical+modeling+and+simulation+in+drug+development+and+regulatory+evaluation&rft.au=Jiang%2C+Wenlei%3BKim%2C+Stephanie%3BZhang%2C+Xinyuan%3BLionberger%2C+Robert+A%3BDavit%2C+Barbara+M%3BConner%2C+Dale+P%3BYu%2C+Lawrence+X&rft.aulast=Jiang&rft.aufirst=Wenlei&rft.date=2011-10-14&rft.volume=418&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2011.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-04 N1 - SubjectsTermNotLitGenreText - Food; Reviews; Pharmaceuticals; Drug development; Development; Drugs DO - http://dx.doi.org/10.1016/j.ijpharm.2011.07.024 ER - TY - JOUR T1 - Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days. AN - 885908956; 21784140 AB - A number of studies have demonstrated that co-exposure to low levels of melamine and cyanuric acid elicits renal toxicity due to the formation of melamine cyanurate crystals in the kidney nephrons. In this work, we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the genes encoding kidney injury molecule 1 (KIM-1), metallopeptidase inhibitor 1 (TIMP1), clusterin, osteopontin, and neutrophil gelatinase-associated lipocalin/lipocalin 2 (NGAL), which have been proposed as urinary biomarkers for nephrotoxicity. Six-week-old male and female F344 rats were fed ad libitum a diet fortified with 0 (control), 7, 23, 69, 229, or 694 ppm melamine and cyanuric acid (co-exposure groups), 1388 ppm melamine, or 1388 ppm cyanuric acid for seven days. Histopathology and clinical chemistry examination indicated marked toxicity only in the animals exposed to the two highest combined doses of melamine and cyanuric acid. Consistent with these observations, quantitative real-time polymerase chain reaction analysis of kidney tissue indicated increased expression of all genes analyzed relative to the control in both male and female rats fed daily with 229 or 694 ppm melamine and cyanuric acid. Exposure to lower levels of both compounds or to the individual compounds did not induce gene expression changes. These data indicate that quantifying the expression levels of the selected biomarker genes constitutes a useful endpoint to assess the combined toxicity of melamine and cyanuric acid in both male and female rats. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Camacho, Luísa AU - Kelly, Kevin P AU - Beland, Frederick A AU - Gamboa da Costa, Gonçalo AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. luisa.camacho@fda.hhs.gov Y1 - 2011/10/10/ PY - 2011 DA - 2011 Oct 10 SP - 166 EP - 171 VL - 206 IS - 2 KW - Acute-Phase Proteins KW - 0 KW - Biomarkers KW - Cell Adhesion Molecules KW - Clu protein, rat KW - Clusterin KW - Environmental Pollutants KW - Havcr1protein, rat KW - Lcn2 protein, rat KW - Lipocalin-2 KW - Lipocalins KW - Proto-Oncogene Proteins KW - RNA, Messenger KW - Spp1 protein, rat KW - Tissue Inhibitor of Metalloproteinase-1 KW - Triazines KW - neutrophil gelatinase-associated lipocalin protein, rat KW - Osteopontin KW - 106441-73-0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Animals KW - Cell Adhesion Molecules -- genetics KW - Acute-Phase Proteins -- genetics KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Osteopontin -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Osteopontin -- genetics KW - Clusterin -- genetics KW - Lipocalins -- metabolism KW - Rats KW - Rats, Inbred F344 KW - No-Observed-Adverse-Effect Level KW - RNA, Messenger -- metabolism KW - Tissue Inhibitor of Metalloproteinase-1 -- metabolism KW - Clusterin -- metabolism KW - Biomarkers -- metabolism KW - Cell Adhesion Molecules -- metabolism KW - Lipocalins -- genetics KW - Proto-Oncogene Proteins -- genetics KW - Acute-Phase Proteins -- metabolism KW - Tissue Inhibitor of Metalloproteinase-1 -- genetics KW - Male KW - Female KW - Triazines -- toxicity KW - Renal Insufficiency -- metabolism KW - Kidney -- metabolism KW - Environmental Pollutants -- toxicity KW - Renal Insufficiency -- chemically induced KW - Kidney -- drug effects KW - Gene Expression Regulation -- drug effects KW - Environmental Pollutants -- administration & dosage KW - Triazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885908956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Gene+expression+of+biomarkers+of+nephrotoxicity+in+F344+rats+co-exposed+to+melamine+and+cyanuric+acid+for+seven+days.&rft.au=Camacho%2C+Lu%C3%ADsa%3BKelly%2C+Kevin+P%3BBeland%2C+Frederick+A%3BGamboa+da+Costa%2C+Gon%C3%A7alo&rft.aulast=Camacho&rft.aufirst=Lu%C3%ADsa&rft.date=2011-10-10&rft.volume=206&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2011.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-21 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods. 2001 Dec;25(4):402-8 [11846609] Toxicol Sci. 2011 Feb;119(2):391-7 [21030430] IARC Sci Publ. 1991;(115):171-86 [1820332] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] J Vet Diagn Invest. 2007 Nov;19(6):616-24 [17998549] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] Toxicology. 2008 Apr 18;246(2-3):91-100 [18289764] Kidney Int. 2008 May;73(9):994-1007 [18272962] Toxicol Sci. 2008 Jun;103(2):371-81 [18308701] Toxicol Sci. 2008 Nov;106(1):251-62 [18689873] Toxicology. 2009 Nov 9;265(1-2):15-26 [19761811] Toxicol Pathol. 2010 Apr;38(3):338-45 [20305092] Nat Biotechnol. 2010 May;28(5):455-62 [20458315] Nat Biotechnol. 2010 May;28(5):478-85 [20458318] Nat Biotechnol. 2010 May;28(5):486-94 [20458319] Pharmacol Res. 2010 Sep;62(3):179-86 [20434560] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2011.07.009 ER - TY - JOUR T1 - Admissions for CABG Procedure in the Elderly: Was There a Change in Access to Teaching Hospitals After 1997? AN - 964195448; 201201445 AB - The purpose of the study is to identify patient attributes associated with teaching hospital admissions in the elderly for coronary artery bypass graft (CABG), and to determine whether admission patterns in teaching hospitals by vulnerable subgroups of the elderly changed during 1997 to 2001, a period with significant changes in CABG admission patterns and financial situation faced by teaching hospitals. The study sample comprises elderly residents in two states, New York and Pennsylvania, and uses Healthcare Cost and Utilization Project State Inpatient data of the Agency for Health Care Research and Quality. Patient characteristics in major teaching hospitals are compared with those in rest of hospitals in a logistic regression framework using a pre-/postdesign, and controlling for county characteristics and resources, distance to hospitals, and hospital size and volume of procedures. Significant patient characteristics associated with a higher likelihood of admission to teaching hospitals included racial/ethnic minority status, transfer cases, Medicaid and private health maintenance organization Insurance. A lower volume of CABG cases and an increased propensity to admit more complex cases characterized the admission patterns in teaching hospitals during 1997 to 2001. Although higher use of teaching hospitals by racial/ethnic minorities persisted, access for Medicaid patients disproportionately declined. Adapted from the source document. JF - Social Work in Public Health AU - Basu, Jayasree AD - Senior Economist, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Jbasu@ahrq.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 605 EP - 620 PB - Taylor & Francis, Philadelphia PA VL - 26 IS - 6 SN - 1937-1918, 1937-1918 KW - Elderly, access, health care organization, hospital performance, cardiac procedure KW - Minority Groups KW - Teaching KW - Quality of Health Care KW - Ethnicity KW - Medicaid KW - Patients KW - Health Care Utilization KW - Health Care Services KW - Hospitals KW - article KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964195448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Public+Health&rft.atitle=Admissions+for+CABG+Procedure+in+the+Elderly%3A+Was+There+a+Change+in+Access+to+Teaching+Hospitals+After+1997%3F&rft.au=Basu%2C+Jayasree&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2011-10-01&rft.volume=26&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Public+Health&rft.issn=19371918&rft_id=info:doi/10.1080%2F19371911003748778 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 22 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Hospitals; Teaching; Patients; Health Care Services; Ethnicity; Minority Groups; Medicaid; Quality of Health Care; Health Care Utilization DO - http://dx.doi.org/10.1080/19371911003748778 ER - TY - JOUR T1 - The Health Insurance Status of Low-Wage Workers: The Role of Workplace Composition and Marital Status AN - 927830496; 201120979 AB - Many of the provisions in the Affordable Care Act (ACA), such as tax credits and penalties for employers, vary by employer size and average wage level. Therefore, knowing the wage and firm size distribution of low-wage workers and how employer-sponsored insurance (ESI) characteristics vary by these dimensions is particularly important for understanding the extent to which low-wage workers and their employers may be affected by different provisions in the ACA. To inform this issue, the authors use data from the 2006 Medical Expenditure Panel Survey-Insurance Component to examine offers of coverage and cost-sharing requirements by the wage distribution and firm size dimensions of employers. They also draw on Medical Expenditure Panel Survey household-level data to describe the household circumstances of low-wage workers. The authors find that where low-wage workers are employed, who their colleagues are, and their spouses' wage levels are important factors in determining low-wage workers' access to coverage and the cost and generosity of such coverage. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Vistnes, Jessica AU - Monheit, Alan C AD - Agency for Healthcare Research and Quality, Rockville, MD, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 607 EP - 623 PB - Sage Publications, Thousand Oaks CA VL - 68 IS - 5 SN - 1077-5587, 1077-5587 KW - health insurance low-wage workers employment-related coverage KW - Businesses KW - Coverage KW - Expenditure KW - Wages KW - Composition KW - Penalties KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/927830496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=The+Health+Insurance+Status+of+Low-Wage+Workers%3A+The+Role+of+Workplace+Composition+and+Marital+Status&rft.au=Vistnes%2C+Jessica%3BMonheit%2C+Alan+C&rft.aulast=Vistnes&rft.aufirst=Jessica&rft.date=2011-10-01&rft.volume=68&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558711401918 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 7 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Wages; Coverage; Businesses; Expenditure; Composition; Penalties DO - http://dx.doi.org/10.1177/1077558711401918 ER - TY - JOUR T1 - CO and CO (sub 2) emissions from spontaneous heating of coal under different ventilation rates AN - 925702930; 2012-027735 AB - Carbon monoxide (CO) and carbon dioxide (CO (sub 2) ) emissions during a spontaneous heating event in a coal mine are important gases to monitor for detecting the spontaneous heating at an early stage. However, in underground coal mines, the CO and CO (sub 2) concentrations and their related fire ratios may be affected by mine ventilation. In this study, CO and CO (sub 2) emissions from spontaneous heating of a U.S. coal sample were evaluated in an isothermal oven under different airflow ventilation rates ranging from 100 to 500 cm (super 3) /min. Laboratory experiments were conducted at oven temperatures of 70, 90, and 100 degrees C. The temperature at the center of the coal sample was continually monitored, while the CO, CO (sub 2) , and oxygen (O (sub 2) ) concentrations of the exit gas were continually measured. The results indicate that CO was generated immediately after the airflow passed through the coal, while CO (sub 2) was generated in a late phase. The amounts of CO generated under different airflow rates were approximately the same at the initial temperature of 70 degrees C, while the amounts of CO generated increased significantly as the airflow rates and initial temperatures increased. The ratio of CO/CO (sub 2) was found to be independent of airflow rate and initial temperature, approaching a constant value of 0.2 quickly if there was no thermal runaway. The value tended to decrease when a thermal runaway took place. The CO/O (sub 2) deficiency ratio was dependent on both airflow rates and the initial temperature. The experimental results are in qualitative agreement with some large-scale test and field monitoring results. JF - International Journal of Coal Geology AU - Yuan, Liming AU - Smith, Alex C Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 24 EP - 30 PB - Elsevier, Amsterdam VL - 88 IS - 1 SN - 0166-5162, 0166-5162 KW - mines KW - experimental studies KW - coal mines KW - techniques KW - spontaneous heating KW - temperature KW - gases KW - carbon dioxide KW - ventilation KW - laboratory studies KW - carbon monoxide KW - sedimentary rocks KW - safety KW - detection KW - coal KW - heating KW - thermal effects KW - instruments KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925702930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=CO+and+CO+%28sub+2%29+emissions+from+spontaneous+heating+of+coal+under+different+ventilation+rates&rft.au=Yuan%2C+Liming%3BSmith%2C+Alex+C&rft.aulast=Yuan&rft.aufirst=Liming&rft.date=2011-10-01&rft.volume=88&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.07.004 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon monoxide; coal; coal mines; detection; experimental studies; gases; heating; instruments; laboratory studies; mines; safety; sedimentary rocks; spontaneous heating; techniques; temperature; thermal effects; ventilation DO - http://dx.doi.org/10.1016/j.coal.2011.07.004 ER - TY - JOUR T1 - Using Sentinel Surveillance System to Monitor Seasonal and Novel H1N1 Influenza Infection in Houston, Texas: Outcome Analysis of 2008-2009 Flu Season AN - 919905340; 201200520 AB - The advent of the novel H1N1 virus prompted the Houston Department of Health and Human services (HDHHS) to use the existing sentinel surveillance system to effectively monitor the situation of novel H1N1 virus in the Houston metropolitan area. The objective of this study was to evaluate the demographic characteristics and common symptoms associated with confirmed cases of seasonal influenza and Novel H1N1 virus reported to HDHHS between October 2008 and October 2009. A total of 30 providers were randomly selected using the probability proportional to size (PPS) sampling technique to participate in a sentinel surveillance system. The system was used to effectively monitor both seasonal and novel H1N1 virus in the Houston metropolitan area. These providers collected and submitted specimens for testing at HDHHS laboratory from patients with influenza-like illness (ILI) symptoms who visited their clinics during the period, October 2008 and October 2009. These data formed the basis of the current study. Data obtained were subjected to both descriptive and inferential statistical analyses using SAS software version 9.1.3. Overall a total of 1,122 ILI cases were reported to HDHHS by sentinel providers and tested by HDHHS laboratory. Of this number 296 (67.5%) specimens tested positive for influenza A; 140 (32.0%) for influenza B, and 2 (0.46%) for influenza A/B. Two hundred and fifty-nine (59%) were confirmed cases of seasonal influenza and 179 (41%) were novel H1N1 subtype, respectively. The median ages for seasonal influenza and novel H1N1 virus were 7 and 8 years, with majority of the cases reported among children of age 5-9 years. Fever was the most common symptom reported among patients with seasonal flu and novel H1N1 virus, followed by cough. Twenty-three percent (23%) of patients who were vaccinated against seasonal flu prior to the epidemic were infected with seasonal flu virus. The sentinel surveillance system provided timely data on the circulating ILI that assisted in making decisions regarding response activities for both seasonal and novel H1N1 influenza. Adapted from the source document. JF - Journal of Community Health AU - Khuwaja, Salma AU - Mgbere, Osaro AU - Awosika-Olumo, Adebowale AU - Momin, Fayaz AU - Ngo, Katherine AD - Bureau of Epidemiology, Houston Department of Health and Human Services (HDHHS), 8000 N. Stadium Drive, Houston, TX, 77054, USA Salma.khuwaja@houstontx.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 857 EP - 863 PB - Springer, New York NY VL - 36 IS - 5 SN - 0094-5145, 0094-5145 KW - Influenza KW - Symptoms KW - Epidemics KW - Patients KW - Computer Software KW - Illness KW - Metropolitan Areas KW - Sociodemographic Factors KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919905340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Using+Sentinel+Surveillance+System+to+Monitor+Seasonal+and+Novel+H1N1+Influenza+Infection+in+Houston%2C+Texas%3A+Outcome+Analysis+of+2008-2009+Flu+Season&rft.au=Khuwaja%2C+Salma%3BMgbere%2C+Osaro%3BAwosika-Olumo%2C+Adebowale%3BMomin%2C+Fayaz%3BNgo%2C+Katherine&rft.aulast=Khuwaja&rft.aufirst=Salma&rft.date=2011-10-01&rft.volume=36&rft.issue=5&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-011-9386-2 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Influenza; Symptoms; Patients; Metropolitan Areas; Health Care Services; Sociodemographic Factors; Epidemics; Computer Software; Illness DO - http://dx.doi.org/10.1007/s10900-011-9386-2 ER - TY - JOUR T1 - Periodic Spirometry in Occupational Setting Improving Quality, Accuracy, and Precision AN - 912920591; 16044336 AB - Objective: Effectiveness of periodic spirometry in medical monitoring depends on spirometry quality. We describe an intervention on spirometry quality and its impact on accuracy and precision of longitudinal measurements. Methods: The intervention was conducted from 2005 to 2010 in a monitoring program involving approximately 2500 firefighters. Intervention supported adherence to 2005 American Thoracic Society/European Respiratory Society recommendations through monitoring of spirometry quality and longitudinal data precision, technician training, change of spirometer, and quality control. Results: The percentage of forced vital capacity tests meeting the American Thoracic Society/European Respiratory Society criteria increased from 60% to 95% and the mean longitudinal forced expiratory volume in 1 second within-person variation decreased from 6% to 4%. The increased accuracy and precision of measurements and estimated rates of forced expiratory volume in 1 second decline were statistically significant. Conclusion: Monitoring of quality and data precision helped to recognize the need for intervention. The intervention improved accuracy and precision of spirometry measurements and their usefulness. JF - Journal of Occupational and Environmental Medicine AU - Hnizdo, E AU - Hakobyan, A AU - Fleming, J L AU - Beeckman-Wagner, L-A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA, ehnizdo@cdc.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1205 EP - 1209 VL - 53 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - firefighter services KW - Training KW - intervention KW - Quality control KW - technicians KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912920591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Periodic+Spirometry+in+Occupational+Setting+Improving+Quality%2C+Accuracy%2C+and+Precision&rft.au=Hnizdo%2C+E%3BHakobyan%2C+A%3BFleming%2C+J+L%3BBeeckman-Wagner%2C+L-A&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2011-10-01&rft.volume=53&rft.issue=10&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823078b8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - firefighter services; Training; Quality control; intervention; technicians DO - http://dx.doi.org/10.1097/JOM.0b013e31823078b8 ER - TY - JOUR T1 - Preparation of reference strains for validation and comparison of mycoplasma testing methods AN - 911155899; 15993857 AB - Aims: To optimize growth conditions for preparation of stocks of mycoplasma reference strains to obtain highly viable and disperse samples with low ratios of genomic copy (GC) number to that of colony forming units (CFU). These stocks are required for assessment of relative limits of detection (LOD) of alternative nucleic acid testing (NAT)-based methods in comparison to the conventional microbiological methods. Methods and Results: A kinetics study was used to assess the changes in ratios between the numbers of GC and CFU at different growth phases of six different mycoplasma cultures Acholeplasma laidlawii, Mycoplasma gallisepticum, Mycoplasma arginini, Mycoplasma fermentans, Mycoplasma orale and Mycoplasma pneumoniae. All tested mycoplasmas demonstrated low GC/CFU ratios ( less than or equal to 10) within the log and early stationary growth phases. A significant increase in GC/CFU ratios was observed at the very late stationary and death phases, when the titre of cultures has declined. Similar patterns of GC/CFU profiles were observed for A. laidlawii and Myc. gallisepticum co-cultured with suspension of Chinese hamster ovary (CHO) cells. Conclusions: Tested mycoplasma strains harvested at the exponential-early stationary phases of growth demonstrated the lowest GC/CFU ratios and low propensity to form filamentous structures or aggregates under proposed conditions and can be used for the preparation of a mycoplasma reference panel for methods comparability study. Significance and Impact of the Study: This study shows that the preparation and use of viable mycoplasma reference strains with low CG/CFU ratios is the most reliable way to adequately evaluate the LOD of alternative NAT-based mycoplasma testing methods. JF - Journal of Applied Microbiology AU - Dabrazhynetskaya, A AU - Volokhov, D V AU - David, S W AU - Ikonomi, P AU - Brewer, A AU - Chang, A AU - Chizhikov, V AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 904 EP - 914 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 111 IS - 4 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Growth conditions KW - Acholeplasma laidlawii KW - Cell culture KW - Mycoplasma pneumoniae KW - stationary phase KW - Myc protein KW - Guanylate cyclase KW - Colonies KW - Mycoplasma fermentans KW - nucleic acids KW - Colony-forming cells KW - Kinetics KW - genomics KW - Mycoplasma arginini KW - Mycoplasma gallisepticum KW - J 02410:Animal Diseases KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Preparation+of+reference+strains+for+validation+and+comparison+of+mycoplasma+testing+methods&rft.au=Dabrazhynetskaya%2C+A%3BVolokhov%2C+D+V%3BDavid%2C+S+W%3BIkonomi%2C+P%3BBrewer%2C+A%3BChang%2C+A%3BChizhikov%2C+V&rft.aulast=Dabrazhynetskaya&rft.aufirst=A&rft.date=2011-10-01&rft.volume=111&rft.issue=4&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2011.05108.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 6 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Myc protein; stationary phase; Guanylate cyclase; Colonies; nucleic acids; Growth conditions; Kinetics; Colony-forming cells; Cell culture; genomics; Mycoplasma fermentans; Acholeplasma laidlawii; Mycoplasma pneumoniae; Mycoplasma gallisepticum; Mycoplasma arginini DO - http://dx.doi.org/10.1111/j.1365-2672.2011.05108.x ER - TY - JOUR T1 - Levels of microbial agents in floor dust during remediation of a water-damaged office building AN - 911153708; 15993764 AB - Abstract We examined the effects of remediation on loads of culturable fungi in floor dust collected from a large water-damaged office building during four cross-sectional surveys (2002, 2004, 2005, and 2007, respectively). We created a binary remediation variable for each year for each sampled workstation using information on remediation associated with water damage obtained from building management and used generalized linear mixed-effects models. We found significantly lower levels of culturable total and hydrophilic fungi at remediated workstations than at non-remediated workstations in 2004 and 2005 after completion of major remediation. The remediation effect, however, disappeared in 2007. The fraction of hydrophilic to total fungal concentrations was lowest in 2004, increased in 2005, and was highest in 2007. Our results indicate that the 2003 remediation lowered dust indices of dampness temporarily, but remediation was incomplete, consistent with a building assessment report of water infiltration. This study demonstrates the utility of longitudinal evaluation of microbial indices during remediation of water damage in this building, in which elimination of sources of moisture was not fully addressed. Our findings indicate that the fraction of hydrophilic fungi derived from concentrations of fungal species may be a useful index for assessing the long-term effectiveness of remediation. This study demonstrates the utility of longitudinal evaluation of microbial indices during remediation of water damage in this building, in which elimination of sources of moisture was incomplete. Our findings indicate that the fraction of hydrophilic fungi derived from concentrations of fungal species may be a useful index for assessing the long-term effectiveness of remediation. JF - Indoor Air AU - Cho, S J AU - Park, J-H AU - Kreiss, K AU - Cox-Ganser, J M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 417 EP - 426 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 21 IS - 5 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts KW - Bioremediation KW - Fungi KW - Infiltration KW - Indoor environments KW - Water infiltration KW - Dust KW - Models KW - P 0000:AIR POLLUTION KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911153708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Levels+of+microbial+agents+in+floor+dust+during+remediation+of+a+water-damaged+office+building&rft.au=Cho%2C+S+J%3BPark%2C+J-H%3BKreiss%2C+K%3BCox-Ganser%2C+J+M&rft.aulast=Cho&rft.aufirst=S&rft.date=2011-10-01&rft.volume=21&rft.issue=5&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2011.00722.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 3 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fungi; Water infiltration; Dust; Models; Bioremediation; Infiltration; Indoor environments DO - http://dx.doi.org/10.1111/j.1600-0668.2011.00722.x ER - TY - JOUR T1 - Clinical and molecular aspects of malaria fever AN - 907181496; 15749674 AB - Although clinically benign, malaria fever is thought to have significant relevance in terms of parasite growth and survival and its virulence which in turn may alter the clinical course of illness. In this article, the historical literature is reviewed, providing some evolutionary perspective on the genesis and biological relevance of malaria fever, and the available molecular data on the febrile-temperature-inducible parasite factors that may contribute towards the regulation of parasite density and alteration of virulence in the host is also discussed. The potential molecular mechanisms that could be responsible for the induction and regulation of cyclical malaria fevers caused by different species of Plasmodium are also discussed. JF - Trends in Parasitology AU - Oakley, Miranda S AU - Gerald, Noel AU - McCutchan, Thomas F AU - Aravind, L AU - Kumar, Sanjai Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 442 EP - 449 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 27 IS - 10 SN - 1471-4922, 1471-4922 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Molecular modelling KW - Parasites KW - Human diseases KW - Data processing KW - Survival KW - Malaria KW - Hosts KW - Public health KW - Fever KW - Virulence KW - Plasmodium KW - Growth KW - Reviews KW - Evolution KW - Benign KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907181496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Parasitology&rft.atitle=Clinical+and+molecular+aspects+of+malaria+fever&rft.au=Oakley%2C+Miranda+S%3BGerald%2C+Noel%3BMcCutchan%2C+Thomas+F%3BAravind%2C+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2011-10-01&rft.volume=27&rft.issue=10&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Trends+in+Parasitology&rft.issn=14714922&rft_id=info:doi/10.1016%2Fj.pt.2011.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Virulence; Parasites; Growth; Human diseases; Malaria; Hosts; Evolution; Public health; Fever; Molecular modelling; Data processing; Reviews; Survival; Benign; Plasmodium DO - http://dx.doi.org/10.1016/j.pt.2011.06.004 ER - TY - JOUR T1 - Fluoroquinolone-Associated Myasthenia Gravis Exacerbation: Evaluation of Postmarketing Reports from the US FDA Adverse Event Reporting System and a Literature Review AN - 902363626; 15813490 AB - Background Exacerbations of myasthenia gravis have been reported in antibacterial-treated patients. In animal and in vitro models of experimentally-induced myasthenia gravis, fluoroquinolones exhibit neuromuscular blockade. Objective The aim of this retrospective study was to evaluate postmarketing adverse event reports submitted to the US FDA and case reports published in the scientific literature for a potential association between fluoroquinolone exposure and acute exacerbations of myasthenia gravis. Methods On 1 March 2011, we searched the FDA Adverse Event Reporting System (AERS) database to retrieve all reports of myasthenia gravis exacerbation as a serious adverse event in patients treated with fluoroquinolones. We also conducted an Internet-based search using EMBASE for additional English-language cases in the scientific literature. Results We identified a total of 37 unique cases describing myasthenia gravis exacerbation following fluoroquinolone systemic exposure. We retrieved AERS reports for 27 non-ventilated patients administered the following fluoroquinolones: levofloxacin (n = 9), moxifloxacin (n = 6), ciprofloxacin (n = 6), ofloxacin (n = 2), gatifloxacin (n = 2), norfloxacin (n = 1) and trovafloxacin (n = 1). Additionally, we retrieved ten case reports published in the literature involving non-ventilated patients administered ciprofloxacin (n = 4), levofloxacin (n = 2) and ofloxacin, norfloxacin, pefloxacin and prulifloxacin (1 patient each). Myasthenia gravis exacerbations developed a median of 1 day following fluoroquinolone exposure. The 37 cases describe dyspnoea (n = 19; 51%), myasthenic crisis requiring ventilatory support (n = 11; 30%) and death (n = 2; 5%). Additional exacerbation-related adverse events were generalized muscle weakness (n = 20; 54%), dysphagia (n = 9; 24%), diplopia (n = 6; 16%) and ptosis (n = 6; 16%). Six patients (16%) experienced a positive rechallenge, with recurrent myasthenia gravis exacerbation after fluoroquinolone reintroduction. Conclusions Fluoroquinolone exposure may result in potentially life-threatening myasthenia gravis exacerbations in patients with underlying disease. Healthcare professionals should be aware of this serious drug-disease association and carefully weigh the benefit-risks of fluoroquinolones when treating infections in non-ventilated myasthenic patients. JF - Drug Safety AU - Jones, S Christopher AU - Sorbello, Alfred AU - Boucher, Robert M AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Division of Pharmacovigilance II, Silver Spring, MD, USA Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 839 EP - 847 PB - Adis International Inc. VL - 34 IS - 10 SN - 0114-5916, 0114-5916 KW - CSA Neurosciences Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Case reports KW - Ciprofloxacin KW - Databases KW - Dysphagia KW - Dyspnea KW - FDA KW - Fluoroquinolones KW - Gatifloxacin KW - Levofloxacin KW - Literature reviews KW - Medical personnel KW - Mortality KW - Moxifloxacin KW - Muscles KW - Myasthenia gravis KW - Neuromuscular junctions KW - Norfloxacin KW - Ofloxacin KW - Pefloxacin KW - Reintroduction KW - Respiration KW - Reviews KW - Side effects KW - Trovafloxacin KW - crises KW - infection KW - reintroduction KW - USA KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902363626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Safety&rft.atitle=Fluoroquinolone-Associated+Myasthenia+Gravis+Exacerbation%3A+Evaluation+of+Postmarketing+Reports+from+the+US+FDA+Adverse+Event+Reporting+System+and+a+Literature+Review&rft.au=Jones%2C+S+Christopher%3BSorbello%2C+Alfred%3BBoucher%2C+Robert+M&rft.aulast=Jones&rft.aufirst=S&rft.date=2011-10-01&rft.volume=34&rft.issue=10&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Drug+Safety&rft.issn=01145916&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/adis/dsf/2011/00000034/00000010/art00004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Reintroduction; Norfloxacin; Fluoroquinolones; Respiration; Levofloxacin; Ofloxacin; Muscles; Pefloxacin; Gatifloxacin; Databases; Ciprofloxacin; Dysphagia; Trovafloxacin; Case reports; Literature reviews; Moxifloxacin; Myasthenia gravis; Neuromuscular junctions; Dyspnea; Mortality; Reviews; crises; infection; FDA; Medical personnel; Side effects; reintroduction; USA ER - TY - JOUR T1 - Systemic cytokine levels and subsequent risk of gastric cancer in Chinese Women. AN - 895854949; 21740481 AB - Although control of the host cytokine network is known to influence gastric cancer susceptibility, the specific inflammatory responses in gastric carcinogenesis remain unclear. We prospectively examined the relationships between gastric cancer risk and plasma levels of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α in a nested case control study within The Shanghai Women's Health Study. Two controls were matched to each case on the basis of age, menopausal status, and sample collection parameters. The associations between gastric cancer risk and tertiles of cytokine levels were estimated by odds ratios (OR) and 95% confidence intervals (CI) from conditional logistic regression, adjusting for education. During a median follow-up period of 4 years (range 0.1-8 years), 141 women developed gastric cancer and were matched to 282 cancer-free study participants. Elevated levels of plasma IL-6 were associated with an increased risk of gastric cancer (P(trend) = 0.04). Risk increased 70% (OR = 1.7; 95% CI 1.0, 3.0) for women in the highest tertile (>4 pg/mL) of IL-6 compared with those in the lowest tertile (<1.8 pg/mL). The association between gastric cancer risk and IL-6 was stronger after 4 years of follow-up (OR = 2.6 [95% CI 1.0, 6.7] for highest versus lowest tertile) compared with an OR of 1.4 (95% CI 0.7, 2.9) for those diagnosed within 1-4 years of follow-up. No associations were observed with the other pro-inflammatory cytokines examined, namely IL-1β, IL-8, and TNF-α. Systemic plasma IL-6 levels may inform long-term gastric cancer risk. This novel finding awaits confirmation in future studies with sequential plasma collection. © 2011 Japanese Cancer Association and this article is a US Government work and is in the public domain in the USA. JF - Cancer science AU - Wong, Hui-Lee AU - Rabkin, Charles S AU - Shu, Xiao-Ou AU - Pfeiffer, Ruth M AU - Cai, Qiuyin AU - Ji, Bu-Tian AU - Yang, Gong AU - Li, Hong-Lan AU - Rothman, Nathaniel AU - Gao, Yu-Tang AU - Zheng, Wei AU - Chow, Wong-Ho AD - US Food and Drug Administration, Silver Spring, Maryland, USA. huilee.wong@fda.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1911 EP - 1915 VL - 102 IS - 10 KW - Cytokines KW - 0 KW - Interleukin-1beta KW - Interleukin-6 KW - Interleukin-8 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Helicobacter pylori KW - Odds Ratio KW - Humans KW - Aged KW - Helicobacter Infections KW - Interleukin-8 -- blood KW - Eating KW - Interleukin-6 -- blood KW - Interleukin-1beta -- blood KW - Prospective Studies KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Confidence Intervals KW - Tumor Necrosis Factor-alpha -- blood KW - Middle Aged KW - China KW - Female KW - Cytokines -- blood KW - Stomach Neoplasms -- blood KW - Stomach Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/895854949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+science&rft.atitle=Systemic+cytokine+levels+and+subsequent+risk+of+gastric+cancer+in+Chinese+Women.&rft.au=Wong%2C+Hui-Lee%3BRabkin%2C+Charles+S%3BShu%2C+Xiao-Ou%3BPfeiffer%2C+Ruth+M%3BCai%2C+Qiuyin%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLi%2C+Hong-Lan%3BRothman%2C+Nathaniel%3BGao%2C+Yu-Tang%3BZheng%2C+Wei%3BChow%2C+Wong-Ho&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2011-10-01&rft.volume=102&rft.issue=10&rft.spage=1911&rft.isbn=&rft.btitle=&rft.title=Cancer+science&rft.issn=1349-7006&rft_id=info:doi/10.1111%2Fj.1349-7006.2011.02033.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Mar 23;404(6776):398-402 [10746728] J Interferon Cytokine Res. 2001 Jan;21(1):45-52 [11177580] Urology. 2001 Dec;58(6):1008-15 [11744478] Nat Rev Cancer. 2002 Jan;2(1):28-37 [11902583] J Interferon Cytokine Res. 2002 Apr;22(4):473-82 [12034030] Nat Med. 2002 Oct;8(10):1089-97 [12219085] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Eur J Cancer. 2003 Jan;39(2):184-91 [12509950] J Surg Oncol. 2003 Aug;83(4):222-6 [12884234] World J Gastroenterol. 2004 Apr 15;10(8):1115-20 [15069709] Gut. 2004 Sep;53(9):1235-43 [15306577] IARC Monogr Eval Carcinog Risks Hum. 1994;61:177-240 [7715070] Cancer Lett. 1995 Aug 16;95(1-2):207-12 [7656232] J Clin Endocrinol Metab. 1997 Jul;82(7):2182-91 [9215292] Infect Dis Clin North Am. 1998 Mar;12(1):185-97 [9494838] J Urol. 1999 Jan;161(1):182-7 [10037394] Gastric Cancer. 2005;8(2):124-31 [15864720] Int J Immunopathol Pharmacol. 2005 Jul-Sep;18(3):457-473 [16164822] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Int J Cancer. 2006 Jun 15;118(12):3030-44 [16404738] Carcinogenesis. 2007 Jan;28(1):118-23 [16885196] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2464-70 [18006938] Prostate Cancer Prostatic Dis. 2008;11(3):258-63 [17876341] Jpn J Clin Oncol. 2008 Sep;38(9):626-33 [18687755] Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3450-6 [19064561] Gastroenterology. 2009 May;136(6):1863-73 [19457415] Helicobacter. 2009 Oct;14(5):108-13 [19751435] Infect Immun. 2010 Jan;78(1):108-14 [19841072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1349-7006.2011.02033.x ER - TY - JOUR T1 - Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver. AN - 894818797; 21785164 AB - Dysregulated intracellular iron homeostasis has been found not only in rodent and human hepatocellular carcinomas but also in several preneoplastic pathological states associated with hepatocarcinogenesis; however, the precise underlying mechanisms of metabolic iron disturbances in preneoplastic liver and the role of these disturbances remain unexplored. In the present study, using an in vivo model of rat hepatocarcinogenesis induced by 2-acetylaminofluorene, we found extensive alterations in cellular iron metabolism at preneoplastic stages of liver carcinogenesis. These were characterized by a substantial decrease in the levels of cytoplasmic non-heme iron in foci of initiated hepatocytes and altered expression of the major genes responsible for the proper maintenance of intracellular iron homeostasis. Gene expression analysis revealed that the decreased intracellular levels of iron in preneoplastic foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1), the only known non-heme iron exporter. Likewise, increased Fpn1 gene expression was found in vitro in TRL1215 rat liver cells with an acquired malignant phenotype, suggesting that upregulation of Fpn1 might be a specific feature of neoplastically transformed cells. Other changes observed in vivo included the downregulation of hepcidin (Hamp) gene, a key regulator of Fpn1, and this was accompanied by decreased levels of CCAAT/enhancer binding proteins alpha and beta, especially at the Hamp promoter. In conclusion, our results demonstrate the significance of altered intracellular iron metabolism in the progression of liver carcinogenesis and suggest that correction of these alterations could possibly affect liver cancer development. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Shpyleva, Svitlana I AU - Muskhelishvili, Levan AU - Tryndyak, Volodymyr P AU - Koturbash, Igor AU - Tokar, Erik J AU - Waalkes, Michael P AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 433 EP - 440 VL - 123 IS - 2 KW - Antimicrobial Cationic Peptides KW - 0 KW - Carcinogens KW - Cation Transport Proteins KW - HAMP protein, human KW - Hamp protein, rat KW - Hepcidins KW - metal transporting protein 1 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Animals KW - Antimicrobial Cationic Peptides -- metabolism KW - Disease Progression KW - Liver -- metabolism KW - Cell Line, Tumor KW - Cation Transport Proteins -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Homeostasis -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Liver -- drug effects KW - Cation Transport Proteins -- metabolism KW - Male KW - Female KW - Antimicrobial Cationic Peptides -- genetics KW - Precancerous Conditions -- genetics KW - Liver Neoplasms -- metabolism KW - Hepatocytes -- drug effects KW - 2-Acetylaminofluorene -- toxicity KW - Precancerous Conditions -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Precancerous Conditions -- metabolism KW - Iron -- metabolism KW - Liver Neoplasms -- genetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894818797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chronic+administration+of+2-acetylaminofluorene+alters+the+cellular+iron+metabolism+in+rat+liver.&rft.au=Shpyleva%2C+Svitlana+I%3BMuskhelishvili%2C+Levan%3BTryndyak%2C+Volodymyr+P%3BKoturbash%2C+Igor%3BTokar%2C+Erik+J%3BWaalkes%2C+Michael+P%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Shpyleva&rft.aufirst=Svitlana&rft.date=2011-10-01&rft.volume=123&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr193 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Pathol. 1984;12(2):136-42 [11478314] Free Radic Biol Med. 2002 May 1;32(9):833-40 [11978485] J Biol Chem. 2002 Oct 25;277(43):41163-70 [12183449] Alcohol. 2003 Jun;30(2):145-50 [12957299] Gastroenterology. 2004 Nov;127(5 Suppl 1):S79-86 [15508107] J Natl Cancer Inst. 1976 Jul;57(1):157-65 [1003498] Cancer Res. 1982 Jun;42(6):2298-309 [7074612] Mutat Res. 1994 Oct;318(2):73-114 [7521935] Environ Health Perspect. 1994 Oct;102 Suppl 6:173-6 [7889843] J Biol Chem. 1995 Dec 29;270(52):31288-93 [8537397] Biochim Biophys Acta. 1997 Mar 14;1331(1):1-40 [9325434] J Biol Chem. 2006 Mar 10;281(10):6734-41 [16407263] Liver Int. 2006 Oct;26(8):976-85 [16953838] Crit Rev Toxicol. 2007 Mar;37(3):211-36 [17453932] Biochem Biophys Res Commun. 2007 Jun 8;357(3):575-8 [17434454] Arch Histol Cytol. 2007 Apr;70(1):1-19 [17558140] Br J Haematol. 2007 Jul;138(2):253-62 [17593032] Liver Int. 2007 Dec;27(10):1394-401 [17927713] Annu Rev Pathol. 2007;2:1-29 [18039091] Gastroenterology. 2008 Jan;134(1):226-38 [18166355] Carcinogenesis. 2008 Mar;29(3):638-46 [18204080] Nat Protoc. 2008;3(6):1101-8 [18546601] BMC Cancer. 2008;8:167 [18541040] Hepatology. 2008 Nov;48(5):1420-9 [18671304] Hematology Am Soc Hematol Educ Program. 2008;:151-8 [19074074] Cancer Sci. 2009 Jan;100(1):9-16 [19018762] Toxicol Lett. 2009 Feb 10;184(3):151-8 [19061943] Toxicol Appl Pharmacol. 2009 Mar 15;235(3):305-11 [19167416] Exp Biol Med (Maywood). 2009 Jun;234(6):693-702 [19307463] Biochim Biophys Acta. 2009 Jul;1790(7):650-62 [19393721] J Cancer Res Clin Oncol. 2009 Oct;135(10):1413-20 [19387685] J Leukoc Biol. 2009 Nov;86(5):1247-58 [19652026] Cancer Biol Ther. 2009 Sep;8(18):1699-708 [19571663] Cancer Lett. 2009 Dec 1;286(1):38-43 [19081672] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Am J Pathol. 2010 Feb;176(2):1006-17 [20019189] Int J Cancer. 2010 Jun 1;126(11):2575-83 [19839049] Hepatology. 2010 May;51(5):1820-32 [20432259] Cell. 2010 Jul 9;142(1):24-38 [20603012] Sci Transl Med. 2010 Aug 4;2(43):43ra56 [20686179] J Hepatol. 2011 Jan;54(1):173-81 [20932599] Annu Rev Med. 2011;62:347-60 [20887198] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr193 ER - TY - JOUR T1 - miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. AN - 894816814; 21750348 AB - The role of trivalent arsenic (As(3+)) on the regulation of the recently identified noncoding small RNAs, mainly microRNAs, has not been explored so far. In the present study, we provide evidence showing that As(3+) is a potent inducer for the expression of miR-190 in human bronchial epithelial cells. The induction of miR-190 by As(3+) is concentration dependent and associated with the expression of the host gene of miR-190, talin 2, a gene encoding a high-molecular-weight cytoskeletal protein. The elevated level of miR-190 induced by As(3+) is capable of downregulating the translation of the PH domain leucine-rich repeat protein phosphatase (PHLPP), a negative regulator of Akt signaling. Such a downregulation is occurred through direct interaction of the miR-190 with the 3'-UTR region of the PHLPP mRNA, leading to a diminished PHLPP protein expression and consequently, an enhanced Akt activation and expression of vascular endothelial growth factor, an Akt-regulated protein. Overexpression of miR-190 itself is able to enhance proliferation and malignant transformation of the cells as determined by anchorage-independent growth of the cells in soft agar. Accordingly, the data presented suggest that induction of miR-190 is one of the key mechanisms in As(3+)-induced carcinogenesis. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Beezhold, Kevin AU - Liu, Jia AU - Kan, Hong AU - Meighan, Terry AU - Castranova, Vince AU - Shi, Xianglin AU - Chen, Fei AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 411 EP - 420 VL - 123 IS - 2 KW - Arsenicals KW - 0 KW - Carcinogens, Environmental KW - MicroRNAs KW - Nuclear Proteins KW - Oxides KW - RNA, Messenger KW - TLN2 protein, human KW - Talin KW - PHLPP1 protein, human KW - EC 3.1.3.16 KW - Phosphoprotein Phosphatases KW - arsenic trioxide KW - S7V92P67HO KW - Index Medicus KW - Talin -- genetics KW - Cell Proliferation -- drug effects KW - Gene Silencing KW - Humans KW - Talin -- metabolism KW - Bronchi -- drug effects KW - Bronchi -- pathology KW - Arsenic Poisoning KW - Epithelial Cells -- drug effects KW - RNA, Messenger -- metabolism KW - Epithelial Cells -- pathology KW - Cell Transformation, Neoplastic -- chemically induced KW - Cell Line KW - Nuclear Proteins -- genetics KW - Phosphoprotein Phosphatases -- metabolism KW - MicroRNAs -- biosynthesis KW - Phosphoprotein Phosphatases -- genetics KW - Gene Expression Regulation -- drug effects KW - Oxides -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Nuclear Proteins -- metabolism KW - Down-Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894816814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=miR-190-mediated+downregulation+of+PHLPP+contributes+to+arsenic-induced+Akt+activation+and+carcinogenesis.&rft.au=Beezhold%2C+Kevin%3BLiu%2C+Jia%3BKan%2C+Hong%3BMeighan%2C+Terry%3BCastranova%2C+Vince%3BShi%2C+Xianglin%3BChen%2C+Fei&rft.aulast=Beezhold&rft.aufirst=Kevin&rft.date=2011-10-01&rft.volume=123&rft.issue=2&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2009 Apr;49(4):1098-112 [19173277] World J Surg. 2009 Apr;33(4):698-709 [19030927] Int J Cancer. 2009 Jul 15;125(2):345-52 [19378336] Gut. 2009 Oct;58(10):1375-81 [19201770] Breast Cancer Res. 2009;11(3):R27 [19432961] J Biomed Biotechnol. 2009;2009:594678 [19606257] PLoS One. 2009;4(11):e8003 [19946373] Environ Health Perspect. 2009 Nov;117(11):1718-23 [20049123] Mol Cancer. 2010;9:134 [20515486] J Biol Chem. 2010 Jul 16;285(29):21994-2002 [20457614] Chemosphere. 2011 Apr;83(3):211-25 [21216433] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1749-53 [10677529] Mol Cell. 2001 Jul;8(1):85-94 [11511362] Biochem Biophys Res Commun. 2001 Sep 7;286(5):880-5 [11527381] Cancer Res. 2003 Nov 15;63(22):7689-93 [14633691] Cell. 2003 Dec 26;115(7):787-98 [14697198] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11755-60 [15284443] EMBO J. 1996 Nov 15;15(22):6269-79 [8947050] Int J Epidemiol. 1998 Aug;27(4):561-9 [9758107] Lung Cancer. 2004 Dec;46(3):265-70 [15541810] JAMA. 2004 Dec 22;292(24):2984-90 [15613666] Nucleic Acids Res. 2005;33(4):1290-7 [15741182] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32 [15738415] Mol Cell. 2005 Apr 1;18(1):13-24 [15808505] Nat Genet. 2005 May;37(5):495-500 [15806104] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Nucleic Acids Res. 2006;34(2):485-95 [16421274] Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1042-8 [16445569] World J Gastroenterol. 2006 Feb 7;12(5):691-6 [16521180] Carcinogenesis. 2006 Apr;27(4):864-73 [16387740] Anticancer Res. 2006 Nov-Dec;26(6B):4391-5 [17201159] EMBO J. 2007 Feb 7;26(3):775-83 [17255951] Cancer Res. 2007 Jun 1;67(11):5293-9 [17545609] J Biol Chem. 2007 Aug 10;282(32):23716-24 [17569667] Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16170-5 [17911264] Exp Hematol. 2007 Nov;35(11):1708-18 [17976522] Nucleic Acids Res. 2008 Jan;36(Database issue):D707-14 [18000006] Cancer Res. 2008 Jan 15;68(2):425-33 [18199536] J Cell Sci. 2008 May 1;121(Pt 9):1345-7 [18434644] RNA. 2008 Jun;14(6):1012-7 [18426918] Cell Cycle. 2008 Jun 1;7(11):1529-38 [18469525] Environ Res. 2008 Sep;108(1):48-55 [18511031] Blood. 2008 Oct 15;112(8):3026-35 [18669872] Nat Cell Biol. 2008 Sep;10(9):1062-8 [19160486] Insect Biochem Mol Biol. 2008 Dec;38(12):1066-71 [18977439] Oncogene. 2009 Feb 19;28(7):994-1004 [19079341] J Transl Med. 2009;7:20 [19309508] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr188 ER - TY - JOUR T1 - Poisoning hospitalisations among reproductive-aged women in the USA, 1998-2006. AN - 894040928; 21296799 AB - To describe poisoning hospitalisations among reproductive-aged women from 1998 to 2006. 1998-2006 data from the Nationwide Inpatient Sample of the Healthcare Cost and Utilisation Project were used to identify hospitalisations for poisonings among US women aged 15-44 years. Differences in hospitalisation characteristics were compared by intent using χ(2) statistics. Trends in poisoning hospitalisation rates were calculated overall and by subgroup. There were approximately 636,000 poisoning hospitalisations in women aged 15-44 years during 1998-2006. Hospitalisations for intentionally self-inflicted poisonings had a higher proportion of women aged 15-24 years and privately insured women than did unintentional poisonings (p<0.001). Poisoning hospitalisations in rural areas and those that resulted in death were more likely to be of undetermined intent than those for which intent was specified (p<0.001). Co-diagnoses of substance abuse (34.5%) or mental disorders (66.5%) were high. The rate of poisoning hospitalisations overall and unintentional poisoning hospitalisations increased 6% and 22%, respectively, during this period (p<0.001). The most frequently diagnosed poisoning agent was acetaminophen. Poisonings attributable to acetaminophen, opioids, central nervous system stimulants and benzodiazepines increased, while poisonings attributable to antidepressants decreased (p<0.05). The increase in unintentional poisoning hospitalisations among women aged 15-44 years and the changing profile of poisoning agents should inform the healthcare community's poisoning prevention strategies. Poisoning prevention strategies should include a component to address substance abuse and mental health disorders among reproductive-age women. JF - Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention AU - Cox, Shanna AU - Kuo, Cassie AU - Jamieson, Denise J AU - Kourtis, Athena P AU - McPheeters, Melissa L AU - Meikle, Susan F AU - Posner, Samuel F AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA. shanna.cox@cdc.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 332 EP - 337 VL - 17 IS - 5 KW - Index Medicus KW - Young Adult KW - Risk Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Self-Injurious Behavior -- epidemiology KW - Adolescent KW - United States -- epidemiology KW - Female KW - Substance-Related Disorders -- epidemiology KW - Poisoning -- epidemiology KW - Hospitalization -- statistics & numerical data KW - Hospitalization -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894040928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.atitle=Poisoning+hospitalisations+among+reproductive-aged+women+in+the+USA%2C+1998-2006.&rft.au=Cox%2C+Shanna%3BKuo%2C+Cassie%3BJamieson%2C+Denise+J%3BKourtis%2C+Athena+P%3BMcPheeters%2C+Melissa+L%3BMeikle%2C+Susan+F%3BPosner%2C+Samuel+F&rft.aulast=Cox&rft.aufirst=Shanna&rft.date=2011-10-01&rft.volume=17&rft.issue=5&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.issn=1475-5785&rft_id=info:doi/10.1136%2Fip.2010.029793 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/ip.2010.029793 ER - TY - JOUR T1 - Effects of Orange II and Sudan III azo dyes and their metabolites on Staphylococcus aureus. AN - 893721922; 21451978 AB - Azo dyes are widely used in the plastic, paper, cosmetics, food, and pharmaceutical industries. Some metabolites of these dyes are potentially genotoxic. The toxic effects of azo dyes and their potential reduction metabolites on Staphylococcus aureus ATCC BAA 1556 were studied. When the cultures were incubated with 6, 18, and 36 μg/ml of Orange II and Sudan III for 48 h, 76.3, 68.5, and 61.7% of Orange II and 97.8, 93.9, and 75.8% of Sudan III were reduced by the bacterium, respectively. In the presence of 36 μg/ml Sudan III, the cell viability of the bacterium decreased to 61.9% after 48 h of incubation, whereas the cell viability of the control culture without the dye was 71.5%. Moreover, the optical density of the bacterial cultures at 10 h decreased from 0.74 to 0.55, indicating that Sudan III is able to inhibit growth of the bacterium. However, Orange II had no significant effects on either cell growth or cell viability of the bacterium at the tested concentrations. 1-Amino-2-naphthol, a metabolite common to Orange II and Sudan III, was capable of inhibiting cell growth of the bacterium at 1 μg/ml and completely stopped bacterial cell growth at 24-48 μg/ml. On the other hand, the other metabolites of Orange II and Sudan III, namely sulfanilic acid, p-phenylenediamine, and aniline, showed no significant effects on cell growth. p-Phenylenediamine exhibited a synergistic effect with 1-amino-2-naphthol on cell growth inhibition. All of the dye metabolites had no significant effects on cell viability of the bacterium. JF - Journal of industrial microbiology & biotechnology AU - Pan, Hongmiao AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1729 EP - 1738 VL - 38 IS - 10 KW - Aniline Compounds KW - 0 KW - Azo Compounds KW - Benzenesulfonates KW - Coloring Agents KW - Naphthols KW - Phenylenediamines KW - Sulfanilic Acids KW - 1-amino-2-naphthol KW - MB1ZPM5M0Z KW - sudan III KW - ND733RX3JN KW - 2-naphthol orange KW - Q1LIY3BO0U KW - aniline KW - SIR7XX2F1K KW - 4-phenylenediamine KW - U770QIT64J KW - Index Medicus KW - Sulfanilic Acids -- toxicity KW - Phenylenediamines -- toxicity KW - Naphthols -- toxicity KW - Aniline Compounds -- toxicity KW - Azo Compounds -- metabolism KW - Coloring Agents -- toxicity KW - Benzenesulfonates -- metabolism KW - Staphylococcus aureus -- growth & development KW - Azo Compounds -- toxicity KW - Coloring Agents -- metabolism KW - Staphylococcus aureus -- drug effects KW - Staphylococcus aureus -- metabolism KW - Benzenesulfonates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893721922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Effects+of+Orange+II+and+Sudan+III+azo+dyes+and+their+metabolites+on+Staphylococcus+aureus.&rft.au=Pan%2C+Hongmiao%3BFeng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2011-10-01&rft.volume=38&rft.issue=10&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-011-0962-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-11 N1 - Date created - 2011-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10295-011-0962-3 ER - TY - JOUR T1 - Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease. AN - 890678166; 21883026 AB - A key to understanding the biological function(s) of the aryl hydrocarbon receptor (AHR) - a xenobiotic-activated receptor - is to identify its endogenous ligand(s). The discovery of a tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) as an endogenous, high affinity agonist of AHR filled this knowledge gap in the context of skin physiology and pathology in response to light and opened several new directions for research on AHR. This paper reviews major developments in the study of light-elicited AHR signaling and its impact on drug metabolism, skin physiology and disease with a focus on the identification of AHR ligands from Trp photoproducts and the AHR-mediated UV response. This review consists of material obtained from Medline and PubMed literature searches up to May 2011. The recognition of FICZ as a potent, endogenous ligand of AHR provided a molecular link between light exposure and AHR signaling and function. The uncovering of the bifurcated signaling pathway of AHR in the mammalian UV response - that is, activation of the cytoplasmic AHR by light via FICZ leads to: i) AHR/AH response element-dependent transcription to induce CYP1A1 and ii) activation of the AHR-pp60(src)-EGFR pathway to induce Cox-2 - put forward a working model for the multiple roles of AHR in skin function and disease that include drug metabolism, circadian oscillation, melanogenesis, inflammation, immunosuppression and cancer. Such findings suggest AHR as a therapeutic target for cancer, autoimmune dysfunction, inflammatory disease and stem cell therapy. JF - Expert opinion on drug metabolism & toxicology AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Rd, Morgantown, WV 26505, USA. qam1@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1267 EP - 1293 VL - 7 IS - 10 KW - 6-formylindolo(3,2-b)carbazole KW - 0 KW - Carbazoles KW - Ligands KW - NF-kappa B KW - Receptors, Aryl Hydrocarbon KW - Tryptophan KW - 8DUH1N11BX KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Cytochrome P-450 CYP1A1 -- genetics KW - Humans KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Tryptophan -- metabolism KW - Skin -- radiation effects KW - Inactivation, Metabolic KW - Light KW - DNA Damage -- radiation effects KW - Signal Transduction KW - Cytochrome P-450 CYP1A1 -- drug effects KW - Immunosuppression KW - NF-kappa B -- metabolism KW - Carbazoles -- pharmacokinetics KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890678166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Influence+of+light+on+aryl+hydrocarbon+receptor+signaling+and+consequences+in+drug+metabolism%2C+physiology+and+disease.&rft.au=Ma%2C+Qiang&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2011-10-01&rft.volume=7&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2011.614947 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2011.614947 ER - TY - JOUR T1 - Novel hemin binding domains in the Corynebacterium diphtheriae HtaA protein interact with hemoglobin and are critical for heme iron utilization by HtaA. AN - 890032817; 21803991 AB - The human pathogen Corynebacterium diphtheriae utilizes hemin and hemoglobin as iron sources for growth in iron-depleted environments. The use of hemin iron in C. diphtheriae involves the dtxR- and iron-regulated hmu hemin uptake locus, which encodes an ABC hemin transporter, and the surface-anchored hemin binding proteins HtaA and HtaB. Sequence analysis of HtaA and HtaB identified a conserved region (CR) of approximately 150 amino acids that is duplicated in HtaA and present in a single copy in HtaB. The two conserved regions in HtaA, designated CR1 and CR2, were used to construct glutathione S-transferase (GST) fusion proteins (GST-CR1 and GST-CR2) to assess hemin binding by UV-visual spectroscopy. These studies showed that both domains were able to bind hemin, suggesting that the conserved sequences are responsible for the hemin binding property previously ascribed to HtaA. HtaA and the CR2 domain were also shown to be able to bind hemoglobin (Hb) by the use of an enzyme-linked immunosorbent assay (ELISA) method in which Hb was immobilized on a microtiter plate. The CR1 domain exhibited a weak interaction with Hb in the ELISA system, while HtaB showed no significant binding to Hb. Competitive binding studies demonstrated that soluble hemin and Hb were able to inhibit the binding of HtaA and the CR domains to immobilized Hb. Moreover, HtaA was unable to bind to Hb from which the hemin had been chemically removed. Alignment of the amino acid sequences of CR domains from various Corynebacterium species revealed several conserved residues, including two highly conserved tyrosine (Y) residues and one histidine (H) residue. Site-directed mutagenesis studies showed that Y361 and H412 were critical for the binding to hemin and Hb by the CR2 domain. Biological assays showed that Y361 was essential for the hemin iron utilization function of HtaA. Hemin transfer experiments demonstrated that HtaA was able to acquire hemin from Hb and that hemin bound to HtaA could be transferred to HtaB. These findings are consistent with a proposed mechanism of hemin uptake in C. diphtheriae in which hemin is initially obtained from Hb by HtaA and then transferred between surface-anchored proteins, with hemin ultimately transported into the cytosol by an ABC transporter. JF - Journal of bacteriology AU - Allen, Courtni E AU - Schmitt, Michael P AD - Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, DBPAP, CBER, FDA, Bldg. 29, Room 108, 8800 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 5374 EP - 5385 VL - 193 IS - 19 KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - Hemeproteins KW - Hemoglobins KW - heme-binding protein KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Molecular Sequence Data KW - Enzyme-Linked Immunosorbent Assay KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Binding KW - Bacterial Proteins -- genetics KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Corynebacterium diphtheriae -- metabolism KW - Bacterial Proteins -- metabolism KW - Corynebacterium diphtheriae -- genetics KW - Hemeproteins -- metabolism KW - Hemoglobins -- metabolism KW - Bacterial Proteins -- chemistry KW - Hemeproteins -- genetics KW - Heme -- metabolism KW - Hemeproteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890032817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Novel+hemin+binding+domains+in+the+Corynebacterium+diphtheriae+HtaA+protein+interact+with+hemoglobin+and+are+critical+for+heme+iron+utilization+by+HtaA.&rft.au=Allen%2C+Courtni+E%3BSchmitt%2C+Michael+P&rft.aulast=Allen&rft.aufirst=Courtni&rft.date=2011-10-01&rft.volume=193&rft.issue=19&rft.spage=5374&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05508-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-14 N1 - Date created - 2011-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2000 Apr;36(1):68-84 [10760164] Infect Immun. 2010 Dec;78(12):4977-89 [20679437] Toxicon. 2001 Nov;39(11):1793-803 [11595641] DNA Cell Biol. 2002 Apr;21(4):281-95 [12042068] Infect Immun. 2002 Aug;70(8):4494-500 [12117961] Biochem Soc Trans. 2002 Aug;30(4):691-6 [12196166] Genome Biol. 2002 Aug 15;3(9):RESEARCH0047 [12225586] Microbes Infect. 2002 Sep;4(11):1149-56 [12361915] Science. 2003 Feb 7;299(5608):906-9 [12574635] Infect Immun. 2003 Mar;71(3):1042-55 [12595414] Nucleic Acids Res. 2003 Nov 15;31(22):6516-23 [14602910] J Bacteriol. 2003 Dec;185(23):6826-40 [14617647] J Biol Chem. 2004 Jan 2;279(1):436-43 [14570922] Mol Microbiol. 2004 Mar;51(5):1509-19 [14982642] Contrib Microbiol. 2005;12:210-33 [15496782] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Methods Enzymol. 1981;76:72-87 [7329287] Infect Immun. 1989 Nov;57(11):3534-9 [2680975] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] Crit Rev Microbiol. 1992;18(3):217-33 [1532495] Mol Microbiol. 1993 Feb;7(3):461-9 [8384684] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9876-80 [7937909] Mol Microbiol. 1994 Aug;13(4):719-32 [7997183] J Infect Dis. 1996 Nov;174(5):1064-72 [8896510] J Bacteriol. 1997 Feb;179(3):838-45 [9006041] Infect Immun. 1997 Nov;65(11):4634-41 [9353044] J Biol Chem. 1998 Jan 9;273(2):837-41 [9422739] J Bacteriol. 2005 Jan;187(2):422-33 [15629913] Infect Immun. 2005 Aug;73(8):5086-92 [16041024] J Bacteriol. 2006 Dec;188(24):8421-9 [17041042] Am J Hematol. 2007 Feb;82(2):134-44 [16986127] Mol Microbiol. 2007 Jan;63(1):139-49 [17229211] J Bacteriol. 2007 May;189(9):3650-4 [17322319] Infect Immun. 2007 Oct;75(10):4857-66 [17664260] J Biol Chem. 2008 Mar 14;283(11):6668-76 [18184657] BMC Microbiol. 2008;8:15 [18215300] J Biol Chem. 2008 Jun 27;283(26):18450-60 [18467329] PLoS Pathog. 2008;4(8):e1000132 [18725935] Infect Immun. 2008 Nov;76(11):5006-15 [18710861] J Biol Chem. 2009 Jan 9;284(2):1166-76 [18984582] J Bacteriol. 2009 Apr;191(8):2638-48 [19201805] J Biol Chem. 2009 Nov 13;284(46):32138-46 [19759022] J Bacteriol. 2010 Jul;192(13):3503-11 [20435727] Mol Microbiol. 2010 Nov;78(3):739-56 [20807204] J Bacteriol. 2001 Feb;183(4):1476-81 [11157965] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05508-11 ER - TY - JOUR T1 - Mortality and end-stage renal disease incidence among dry cleaning workers. AN - 889451215; 21172794 AB - Perchloroethylene (PCE) is a known animal carcinogen and probable human carcinogen. Dry cleaning exposures, particularly PCE, are also associated with renal toxicity. The objective was to follow-up a cohort of dry cleaners to evaluate mortality and assess end-stage renal disease (ESRD) morbidity. This study adds 8 years of mortality follow-up for 1704 dry cleaning workers in four cities. Employees eligible for inclusion worked for ≥1 year before 1960 in a shop using PCE as the primary solvent. Life table analyses for mortality and ESRD morbidity were conducted. Only employees alive on 1 January 1977 were included in ESRD analyses. Overall cancer deaths were in significant excess in this cohort (standardised mortality ratio (SMR) 1.22, 95% CI 1.09 to 1.36). Oesophageal, lung and tongue cancers had significant excesses of deaths. Oesophageal cancer risk was highest among those employed in a PCE-using shop for ≥5 years with ≥20 years' latency since first such employment. Deaths from non-malignant underlying diseases of the stomach and duodenum were in significant excess. Hypertensive ESRD morbidity was significantly elevated in the entire cohort (standardised incidence ratio (SIR) 1.98, 95% CI 1.11 to 3.27), and among workers employed only in PCE-using dry cleaning shops for ≥5 years. Employment in the dry cleaning industry and occupational exposure to PCE are associated with an increased risk for ESRD and for cancer at several sites. The employment duration findings for oesophageal cancer and hypertensive ESRD further support an association with PCE exposure instead of lifestyle or socioeconomic factors. JF - Occupational and environmental medicine AU - Calvert, Geoffrey M AU - Ruder, Avima M AU - Petersen, Martin R AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA. jac6@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 709 EP - 716 VL - 68 IS - 10 KW - Solvents KW - 0 KW - Tetrachloroethylene KW - TJ904HH8SN KW - Index Medicus KW - Young Adult KW - Stomach Diseases -- chemically induced KW - Humans KW - Head and Neck Neoplasms -- chemically induced KW - Head and Neck Neoplasms -- mortality KW - Duodenal Diseases -- mortality KW - Morbidity KW - Duodenal Diseases -- chemically induced KW - Adult KW - Stomach Diseases -- mortality KW - Incidence KW - Follow-Up Studies KW - United States -- epidemiology KW - Time Factors KW - Laundering KW - Female KW - Male KW - Solvents -- toxicity KW - Occupational Exposure -- adverse effects KW - Tetrachloroethylene -- toxicity KW - Kidney Failure, Chronic -- chemically induced KW - Occupational Diseases -- chemically induced KW - Kidney Failure, Chronic -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/889451215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Mortality+and+end-stage+renal+disease+incidence+among+dry+cleaning+workers.&rft.au=Calvert%2C+Geoffrey+M%3BRuder%2C+Avima+M%3BPetersen%2C+Martin+R&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2011-10-01&rft.volume=68&rft.issue=10&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2010.060665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-15 N1 - Date created - 2011-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2010.060665 ER - TY - JOUR T1 - Quantification of total and specific gram-negative histamine-producing bacteria species in fish using an MPN real-time PCR method AN - 888114192; 15519150 AB - Quantification of histamine-producing bacteria (HPB) is necessary in order to elucidate the role that HPB play in scombrotoxin (histamine) fish poisoning. We report here the evaluation of a real-time PCR method for the quantification of total and specific Gram-negative HPB species in fish using a most probable number (MPN) format. The species-specific real-time PCR assay was 100% inclusive for independently detecting Morganella morganii, Enterobacter aerogenes, Raoultella planticola/ornithinolytica and Photobacterium damselae and did not cross react with other histamine- or non- histamine-producing bacteria. The efficiency of the reactions in the absence and presence of Spanish mackerel enrichment containing 1 106 CFU/ml of background microflora were 93-104 and 92-99%, respectively. The MPN-real-time PCR assay accurately quantified total and specific HPB in spiked mahi-mahi (Coryphaena hippurus) and Spanish mackerel (Scomberomorus maculates) samples. These methods were used to quantify total and specific HPB in naturally contaminated, decomposing mahi-mahi, Spanish mackerel and tuna (Thunnus albacares) samples. The results of this study indicate that MPN-real-time PCR assays can be used to accurately enumerate total and specific HPB in fish samples. These assays can be applied to assess the effectiveness of mitigation strategies and understand the relationship between HPB and histamine production in decomposing fish. JF - Food Microbiology AU - Bjornsdottir-Butler, Kristin AU - Jones, Jessica L AU - Benner, Ronald A AU - Burkhardt, William Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1284 EP - 1292 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 7 SN - 0740-0020, 0740-0020 KW - ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Marine KW - Thunnus albacares KW - Nucleotide sequence KW - Morganella morganii KW - Poisoning KW - Raoultella planticola KW - Enterobacter aerogenes KW - Histamine KW - Marine fish KW - Photobacterium damselae KW - Most probable number KW - Coryphaena hippurus KW - Scomberomorus maculates KW - Colony-forming cells KW - Microbiology KW - Fish poisoning KW - Scomber KW - Microflora KW - DNA KW - Polymerase chain reaction KW - Histamines KW - Pollution control KW - Q1 08341:General KW - A 01330:Food Microbiology KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888114192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Quantification+of+total+and+specific+gram-negative+histamine-producing+bacteria+species+in+fish+using+an+MPN+real-time+PCR+method&rft.au=Bjornsdottir-Butler%2C+Kristin%3BJones%2C+Jessica+L%3BBenner%2C+Ronald+A%3BBurkhardt%2C+William&rft.aulast=Bjornsdottir-Butler&rft.aufirst=Kristin&rft.date=2011-10-01&rft.volume=28&rft.issue=7&rft.spage=1284&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Marine fish; Nucleotide sequence; Fish poisoning; Microbiology; DNA; Polymerase chain reaction; Histamines; Pollution control; Most probable number; Colony-forming cells; Poisoning; Microflora; Histamine; Photobacterium damselae; Coryphaena hippurus; Thunnus albacares; Scomberomorus maculates; Scomber; Morganella morganii; Raoultella planticola; Enterobacter aerogenes; Marine DO - http://dx.doi.org/10.1016/j.fm.2011.05.006 ER - TY - JOUR T1 - The evolution of skin notations for occupational risk assessment: a new NIOSH strategy. AN - 888089892; 21689711 AB - This article presents an overview of a strategy for assignment of hazard-specific skin notations (SK), developed by the National Institute for Occupational Safety and Health (NIOSH). This health hazard characterization strategy relies on multiple SKs capable of delineating systemic (SYS), direct (DIR), and immune-mediated (SEN) adverse effects caused by dermal exposures to chemicals. One advantage of the NIOSH strategy is the ability to combine SKs when it is determined that a chemical may cause multiple adverse effects following dermal contact (e.g., SK: SYS-DIR-SEN). Assignment of the SKs is based on a weight-of-evidence (WOE) approach, which refers to the critical examination of all available data from diverse lines of evidence and the derivation of a scientific interpretation based on the collective body of data including its relevance, quality, and reported results. Numeric cutoff values, based on indices of toxic potency, serve as guidelines to aid in consistently determining a chemical's relative toxicity and hazard potential. The NIOSH strategy documents the scientific rationale for determination of the hazard potential of a chemical and the subsequent assignment of SKs. A case study of acrylamide is presented as an application of the NIOSH strategy. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Dotson, G Scott AU - Chen, Chen-Peng AU - Gadagbui, Bernard AU - Maier, Andrew AU - Ahlers, Heinz W AU - Lentz, Thomas J AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45227, USA. fya8@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 53 EP - 62 VL - 61 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Risk KW - Animals KW - Humans KW - Male KW - Female KW - Occupational Exposure KW - Hazardous Substances -- classification KW - Skin -- drug effects KW - Skin -- metabolism KW - Hazardous Substances -- pharmacokinetics KW - Skin Diseases -- metabolism KW - Skin Diseases -- mortality KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Risk Assessment -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888089892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+evolution+of+skin+notations+for+occupational+risk+assessment%3A+a+new+NIOSH+strategy.&rft.au=Dotson%2C+G+Scott%3BChen%2C+Chen-Peng%3BGadagbui%2C+Bernard%3BMaier%2C+Andrew%3BAhlers%2C+Heinz+W%3BLentz%2C+Thomas+J&rft.aulast=Dotson&rft.aufirst=G&rft.date=2011-10-01&rft.volume=61&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-06 N1 - Date created - 2011-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.06.002 ER - TY - JOUR T1 - Benzocaine-induced methemoglobinemia in an acute-exposure rat model. AN - 885563987; 21726594 AB - Tricaine methanesulfonate, a sedative for temporarily immobilizing fish, has a 21-day withdrawal time. Benzocaine has been proposed as an alternative sedative because a withdrawal period may not be required. Since benzocaine is known to induce methemoglobinemia, the potential for orally administered benzocaine to induce methemoglobin was assessed in rats. Sprague-Dawley rats were given a single gavage administration of 64mg benzocaine hydrochloride per kg bw and then euthanized at intervals up to 120min. Plasma levels of benzocaine were relatively low at all times, whereas methemoglobin peaked at 24min. Additional rats were orally gavaged with 0-1024mg benzocaine hydrochloride per kg bw and euthanized after 24min. Plasma levels of benzocaine increased from 0.01μM at 2mg per kg bw to 2.9μM at 1024mg per kg bw. Methemoglobin levels did not differ from controls at doses up to 32mg per kg bw in females and 64mg per kg bw in males, whereupon the value increased to ∼80% at 1024mg per kg bw. These data were used to estimate the potential impact of benzocaine residues in fish and suggest that the consumption of fish treated with benzocaine hydrochloride will not cause methemoglobinemia in humans. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Von Tungeln, Linda S AU - Zhou, Tong AU - Woodling, Kellie A AU - Doerge, Daniel R AU - Greenlees, Kevin J AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2530 EP - 2535 VL - 49 IS - 10 KW - Anesthetics, Local KW - 0 KW - Methemoglobin KW - 9008-37-1 KW - Benzocaine KW - U3RSY48JW5 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Linear Models KW - Male KW - Female KW - Anesthetics, Local -- blood KW - Methemoglobin -- metabolism KW - Methemoglobinemia -- chemically induced KW - Methemoglobinemia -- blood KW - Anesthetics, Local -- toxicity KW - Benzocaine -- toxicity KW - Benzocaine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Benzocaine-induced+methemoglobinemia+in+an+acute-exposure+rat+model.&rft.au=Von+Tungeln%2C+Linda+S%3BZhou%2C+Tong%3BWoodling%2C+Kellie+A%3BDoerge%2C+Daniel+R%3BGreenlees%2C+Kevin+J%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2011-10-01&rft.volume=49&rft.issue=10&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.06.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-22 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.06.048 ER - TY - JOUR T1 - Cellular glutathione in fatty liver in vitro models. AN - 885560475; 21620948 AB - The range of non-alcoholic fatty liver disease (NAFLD) includes simple hepatic steatosis, the inflammatory non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. The accumulation of specific lipids in hepatocytes has been associated with oxidative stress and progression of the disease. Elevated serum free fatty acids and hepatocyte lipotoxicity can be studied in an in vitro cellular model. For this purpose, we cultured the human liver cell line, HepG2/C3A, in medium supplemented with increasing amounts of oleic acid (C18:1) and evaluated oxidative stress by measuring the content of the cellular antioxidant, glutathione (GSH). We observed a dose-dependent steatosis, as determined by Nile Red staining, with concurrent increases of GSH; similar findings were also observed in cultured human hepatocytes. Cells cultured with palmitic acid (C16:0) or the combination oleic/palmitic acids (2:1 ratio) also exhibited a dose-dependent increase of GSH; however palmitic-supplemented cultures did not sustain the GSH increase after 24h. We also detected an increase in the formation of lipid peroxides (LPO) indicating that the increase of GSH was a cellular mechanism that may be related to the high exposure of fatty acids. The results of this in vitro study suggest an antioxidant response against fat overloading and indicate potential differences in response to specific fatty acid-induced hepatic steatosis and associated lipotoxicity. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Garcia, Martha C AU - Amankwa-Sakyi, Margaret AU - Flynn, Thomas J AD - FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States. martha.garcia@fda.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1501 EP - 1506 VL - 25 IS - 7 KW - Lipid Peroxides KW - 0 KW - Oleic Acid KW - 2UMI9U37CP KW - Palmitic Acid KW - 2V16EO95H1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Hep G2 Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Oxidative Stress -- drug effects KW - Middle Aged KW - Lipid Peroxides -- metabolism KW - Models, Biological KW - Lipid Peroxidation KW - Male KW - Female KW - Palmitic Acid -- administration & dosage KW - Hepatocytes -- drug effects KW - Fatty Liver -- chemically induced KW - Fatty Liver -- metabolism KW - Oleic Acid -- administration & dosage KW - Glutathione -- metabolism KW - Palmitic Acid -- toxicity KW - Fatty Liver -- pathology KW - Oleic Acid -- toxicity KW - Hepatocytes -- pathology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885560475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Cellular+glutathione+in+fatty+liver+in+vitro+models.&rft.au=Garcia%2C+Martha+C%3BAmankwa-Sakyi%2C+Margaret%3BFlynn%2C+Thomas+J&rft.aulast=Garcia&rft.aufirst=Martha&rft.date=2011-10-01&rft.volume=25&rft.issue=7&rft.spage=1501&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2011.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-26 N1 - Date created - 2011-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tiv.2011.05.011 ER - TY - JOUR T1 - Determination of Levamisole in Urine by Gas Chromatography-Mass Spectrometry AN - 1093456986; 17185803 AB - The United States Public Health Service Substance Abuse and Mental Health Services Administration is alerting medical professionals that a substantial percentage of cocaine imported into the United States is adulterated with levamisole, a veterinary pharmaceutical that can cause blood cell disorders such as severe neutropenia and agranulocytosis. Levamisole HCl is the active ingredient in a number of veterinary drugs approved to treat worm infestations in animals. Levamisole HCl was also the active ingredient in a human drug for oral administration approved on June 18, 1990, as adjuvant treatment in combination with fluorouracil after surgical resection in patients with Duke's stage C colon cancer. This drug was withdrawn from the U.S. market around 2000, and it has not been marketed in the U.S. since then. The objective of this study was to develop a method to determine the amount of levamisole in urine samples. The procedure will be provided to state health laboratories as needed to be used in the evaluation of patients that have developed neutropenia or agranulocytosis in the setting of recent cocaine use. A gas chromatography-mass spectrometry method was validated and tested at two different laboratories, and the method limit of detection for levamisole is 1 ng/mL in urine when using a 5-mL sample. Confirmation of the stereoisomer of levamisole was done by high-performance liquid chromatography using a chiral column. JF - Journal of Analytical Toxicology AU - Trehy, Michael L AU - Brown, Daniel J AU - Woodruff, Jeffrey T AU - Westenberger, Benjamin J AU - Nychis, William G AU - Reuter, Nicholas AU - Schier, Joshua G AU - Vagi, Sara J AU - Hwang, Rong-Jen AD - U.S. FDA/CDER/DPA, 1114 Market Street, St. Louis, Missouri 63101, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 545 EP - 550 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 35 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Adjuvants KW - Blood cells KW - Cocaine KW - Colon cancer KW - Drug abuse KW - Gas chromatography KW - High-performance liquid chromatography KW - Infestation KW - Mass spectroscopy KW - Mental disorders KW - Neutropenia KW - Oral administration KW - Pharmaceuticals KW - Public health KW - Stereoisomers KW - Urine KW - levamisole KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093456986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Determination+of+Levamisole+in+Urine+by+Gas+Chromatography-Mass+Spectrometry&rft.au=Trehy%2C+Michael+L%3BBrown%2C+Daniel+J%3BWoodruff%2C+Jeffrey+T%3BWestenberger%2C+Benjamin+J%3BNychis%2C+William+G%3BReuter%2C+Nicholas%3BSchier%2C+Joshua+G%3BVagi%2C+Sara+J%3BHwang%2C+Rong-Jen&rft.aulast=Trehy&rft.aufirst=Michael&rft.date=2011-10-01&rft.volume=35&rft.issue=8&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/2011/00000035/00000008/art00003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Oral administration; Stereoisomers; Adjuvants; Colon cancer; Drug abuse; Mass spectroscopy; Public health; Neutropenia; Mental disorders; Infestation; Urine; Gas chromatography; Pharmaceuticals; Blood cells; Cocaine; levamisole ER - TY - JOUR T1 - Practical considerations for the rapid screening for pesticides using ambient pressure desorption ionisation with high-resolution mass spectrometry AN - 1038597923; 17045468 AB - A rapid screening method for pesticides has been developed to streamline the processing of produce entering the United States. Foam swabs were used to recover multi-class mixtures of 240, 140, 132 and 60 pesticides from the surfaces of apples, kiwis, peaches and tomatoes. The mixtures were selected to span a large range of chemical classes, polarities, solubilities and sizes to provide a broad look at how this technique will perform for a variety of analytes. The swabs were analysed using direct analysis in real-time (DART) ionisation coupled with a high-resolution Exactive Orbitrap(TM) mass spectrometer. This study expands the types of commodities analysed using this method and explores the feasibility of compositing multiple units of produce per batch to analyse a representative sample. It was established that whilst smooth-skinned produce, such as apples, maintained a high detection rate for the pesticide mixtures even when ten apples are swabbed with one foam disk, commodities with rougher surfaces, such as peaches, suffered a decrease in detection rate when ten peaches are swabbed with one foam disk. In order to maintain some consistency across the sample preparation process, a composite size of three units was selected. The varying topography of the commodities necessitated minor modifications to the method; for example, analysis of kiwi required that the hair on the surface be shaved prior to swabbing to achieve good recovery. Additionally, the effect of storage conditions on detection rate was analysed by spiking the surface of tomatoes at levels of 5 and 10 ng g-1 for each pesticide, storing them under refrigeration and ambient conditions for 3 and 8 days, and then analysing the surface using this method. After 8 days of storage under both conditions more than 80% of the pesticides in the mixture were detected. Also, analysis of the multi-class mixtures was performed in both positive- and negative-ion mode and many classes were detected in both modes. Some classes, such thiocarbamates, phenylamides and organochlorine pesticides, were only observed in the positive-ion mode, whilst benzoylphenylurea pesticides were only detected in the negative-ion mode. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Edison, SE AU - Lin, LA AU - Parrales, L AD - US Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1393 EP - 1404 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 28 IS - 10 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Desorption KW - Feasibility studies KW - Food additives KW - Mass spectrometry KW - Organochlorine pesticides KW - Pesticides KW - Risk assessment KW - Storage KW - Topography KW - Prunus KW - Lycopersicon esculentum KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038597923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Practical+considerations+for+the+rapid+screening+for+pesticides+using+ambient+pressure+desorption+ionisation+with+high-resolution+mass+spectrometry&rft.au=Edison%2C+SE%3BLin%2C+LA%3BParrales%2C+L&rft.aulast=Edison&rft.aufirst=SE&rft.date=2011-10-01&rft.volume=28&rft.issue=10&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.596165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Feasibility studies; Risk assessment; Storage; Food additives; Desorption; Organochlorine pesticides; Pesticides; Mass spectrometry; Topography; Lycopersicon esculentum; Prunus; USA DO - http://dx.doi.org/10.1080/19440049.2011.596165 ER - TY - JOUR T1 - Reducing Racial And Ethnic Disparities: The Action Plan From The Department Of Health And Human Services AN - 1030869755; 201205330 AB - The Department of Health and Human Services (HHS) recently unveiled the most comprehensive federal commitment yet to reducing racial and ethnic health disparities. The 2011 HHS Action Plan to Reduce Racial and Ethnic Health Disparities not only responds to advice previously offered by stakeholders around the nation, but it also capitalizes on new and unprecedented opportunities in the Affordable Care Act of 2010 to benefit diverse communities. The Action Plan advances five major goals: transforming health care; strengthening the infrastructure and workforce of the nation's health and human services; advancing Americans' health and well-being; promoting scientific knowledge and innovation; and upholding the accountability of HHS for making demonstrable progress. By mobilizing HHS around these goals, the Action Plan moves the country closer to realizing the vision of a nation free of disparities in health and health care. Adapted from the source document. JF - Health Affairs AU - Koh, Howard K AU - Graham, Garth AU - Glied, Sherry A AD - Department of Health and Human Services (HHS), in Washington, D.C Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1822 EP - 1829 PB - Project HOPE, Bethesda MD VL - 30 IS - 10 SN - 0278-2715, 0278-2715 KW - Human Services KW - Well Being KW - Scientific Knowledge KW - Interest Groups KW - Innovations KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030869755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Reducing+Racial+And+Ethnic+Disparities%3A+The+Action+Plan+From+The+Department+Of+Health+And+Human+Services&rft.au=Koh%2C+Howard+K%3BGraham%2C+Garth%3BGlied%2C+Sherry+A&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2011-10-01&rft.volume=30&rft.issue=10&rft.spage=1822&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0673 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care Services; Human Services; Innovations; Well Being; Interest Groups; Scientific Knowledge DO - http://dx.doi.org/10.1377/hlthaff.2011.0673 ER - TY - JOUR T1 - A multicenter study on the audiometric findings of styrene-exposed workers AN - 1023095882; 201216859 AB - Objective: The objective of this study was to evaluate hearing loss among workers exposed to styrene, alone or with noise. Design: This cross-sectional study was conducted as part of NoiseChem, a European Commission 5th Framework Programme research project, by occupational health institutes in Finland, Sweden, and Poland. Study sample: Participants' ages ranged from 18-72 years (n = 1620 workers). Participants exposed to styrene, alone or with noise, were from reinforced fiberglass products manufacturing plants (n = 862). Comparison groups were comprised of workers noise-exposed (n = 400) or controls (n = 358). Current styrene exposures ranged from 0 to 309 mg/m3, while mean current noise levels ranged from 70-84 dB(A). Hearing thresholds of styrene-exposed participants were compared with Annexes A and B from ANSI S3.44, 1996. Results: The audiometric thresholds of styrene exposed workers were significantly poorer than those in published standards. Age, gender, and styrene exposure met the significance level criterion in the multiple logistic regression for the binary outcome 'hearing loss' (P = 0.0000). Exposure to noise (<85 dBA p = 0.0001; =85 dB(A) p = 0.0192) interacted significantly with styrene exposure. Conclusions: Occupational exposure to styrene is a risk factor for hearing loss, and styrene-exposed workers should be included in hearing loss prevention programs. Adapted from the source document. JF - International Journal of Audiology AU - Morata, Thais C AU - Sliwinska-Kowalska, Mariola AU - Johnson, Ann-Christin AU - Starck, Jukka AU - Pawlas, Krystyna AU - Zamyslowska-Szmytke, Ewa AU - Nylen, Per AU - Toppila, Esko AU - Krieg, Edward AU - Pawlas, Natalia AU - Prasher, Deepak AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health tmorata@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 652 EP - 660 PB - Informa Healthcare, Taylor and Francis, London UK VL - 50 IS - 10 SN - 1499-2027, 1499-2027 KW - Pure-tone audiometry, Otologically unscreened, Noise, Hearing loss KW - Cross-sectional studies KW - Noise KW - Hearing KW - Hearing impairment KW - Occupational exposure KW - Thresholds KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023095882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=A+multicenter+study+on+the+audiometric+findings+of+styrene-exposed+workers&rft.au=Morata%2C+Thais+C%3BSliwinska-Kowalska%2C+Mariola%3BJohnson%2C+Ann-Christin%3BStarck%2C+Jukka%3BPawlas%2C+Krystyna%3BZamyslowska-Szmytke%2C+Ewa%3BNylen%2C+Per%3BToppila%2C+Esko%3BKrieg%2C+Edward%3BPawlas%2C+Natalia%3BPrasher%2C+Deepak&rft.aulast=Morata&rft.aufirst=Thais&rft.date=2011-10-01&rft.volume=50&rft.issue=10&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.588965 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Noise; Hearing impairment; Thresholds; Hearing; Cross-sectional studies; Occupational exposure DO - http://dx.doi.org/10.3109/14992027.2011.588965 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIETHYLAMINE (CAS No. 109-89-7) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) AN - 1018529564; 22127322 AB - Diethylamine is used in the production of a corrosion inhibitor and also of pesticides, insect repellants and rubber products. Diethylamine vapors are strong irritants to the eyes, nose, and throat of workers. We studied long-term exposure of lower concentrations of diethylamine to rats and mice to see if it caused cancer or other toxic effects. We exposed groups of 50 male and female rats to atmospheres containing 31, 62.5, or 125 parts per million (ppm) of diethylamine. We also exposed groups of 50 male and female mice to atmospheres containing 16, 31, or 62.5 ppm diethylamine. Similar groups of 50 animals were exposed only to clean air in the same exposure chambers and served as the control groups. Animals were exposed 6 hours per day, 5 days per week for 2 years. Tissues from more than 40 sites were examined for every animal. The nose was the main site of injury for all groups of rats and mice exposed to diethylamine. A variety of lesions were observed in the nasal cavity, including atrophy, hyperplasia and metaplasia of the olfactory epithelium in rats and mice and hyperplasia and metaplasia of the respiratory epithelium in rats and squamous metaplasia of the respiratory epithelium in mice. Inflammation of the cornea was observed in some exposed male rats, and inflammation of the pleura and lung were observed in exposed female rats. We conclude that exposure to diethylamine caused a spectrum of inflammatory lesions in the nose of male and female rats and mice and lesions in the eye of male rats and pleura and lung of female rats. There was no evidence that diethylamine caused any cancers in these studies. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1 EP - 174 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Diethylamines KW - Environmental Pollutants KW - Mutagens KW - diethylamine KW - Carcinogens KW - Toxicology KW - Rodents KW - Studies KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Nose Diseases -- chemically induced KW - Escherichia coli -- genetics KW - Salmonella typhimurium -- drug effects KW - Rats KW - Rats, Inbred F344 KW - Lung Diseases -- chemically induced KW - Escherichia coli -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Nose Diseases -- pathology KW - Corneal Diseases -- pathology KW - Salmonella typhimurium -- genetics KW - Male KW - Inflammation -- pathology KW - Corneal Diseases -- chemically induced KW - Pleural Diseases -- pathology KW - Lung Diseases -- pathology KW - Mutagens -- toxicity KW - Mice KW - Mice, Inbred Strains KW - Mutagenicity Tests KW - Pleural Diseases -- chemically induced KW - Neoplasms -- pathology KW - Inhalation Exposure KW - Carcinogenicity Tests KW - Female KW - Environmental Pollutants -- toxicity KW - Neoplasms -- chemically induced KW - Inflammation -- chemically induced KW - Diethylamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+DIETHYLAMINE+%28CAS+No.+109-89-7%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1018529559 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1018529549 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Unpacking the Blockers: Understanding Perceptions and Social Constraints of Health Communication in Hereditary Breast Ovarian Cancer (HBOC) Susceptibility Families AN - 1018378131; 201211580 AB - Family communication is essential for accurate cancer risk assessment and counseling; family blockers play a role in this communication process. This qualitative analysis of social exchanges is an extension of earlier work characterizing those who are perceived by study participants as health information gatherers, disseminators, and blockers within families with Hereditary Breast and Ovarian Cancer (HBOC) susceptibility. Eighty-nine women, ages 23-56 years, enrolled in a Breast Imaging Study (BIS) and participated in a sub-study utilizing a social assessment tool known as the Colored Ecological Genetic Relational Map (CEGRM). Purposive sampling ensured that participants varied according to numbers of participating family members e.g., ranging from 1 to 6. Eighty-nine women from 42 families (1-8 relatives/family) participated. They collectively designated 65 blockers, both male and female. Situational factors, beliefs, attitudes and cultural traditions, privacy and protectiveness comprised perceived reasons for blocking intra-family health communications. Longitudinal data collected over 4 years showed families where blocking behavior was universally recognized and stable over time, as well as other families where blocking was less consistent. Self-blocking was observed among a significant minority of participating women. Blocking of health communications among family members with HBOC was variable, complex, and multifaceted. The reasons for blocking were heterogeneous; duration of the blocking appeared to depend on the reasons for blocking. Blocking often seemed to involve bi-directional feedback loops, in keeping with Lepore's Social Constraints and Modulation Theory. Privacy and protectiveness predominated as explanations for long-term blocking. Adapted from the source document. JF - Journal of Genetic Counseling AU - Peters, June A AU - Kenen, Regina AU - Hoskins, Lindsey M AU - Koehly, Laura M AU - Graubard, Barry AU - Loud, Jennifer T AU - Greene, Mark H AD - Clinical Genetics Branch (CGB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd, Rockville, MD, 20852, USA petersju@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 450 EP - 464 PB - Springer Science+Business Media, New York NY VL - 20 IS - 5 SN - 1059-7700, 1059-7700 KW - Ovarian cancer KW - Blocking KW - Women KW - Health KW - Relatives KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018378131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Unpacking+the+Blockers%3A+Understanding+Perceptions+and+Social+Constraints+of+Health+Communication+in+Hereditary+Breast+Ovarian+Cancer+%28HBOC%29+Susceptibility+Families&rft.au=Peters%2C+June+A%3BKenen%2C+Regina%3BHoskins%2C+Lindsey+M%3BKoehly%2C+Laura+M%3BGraubard%2C+Barry%3BLoud%2C+Jennifer+T%3BGreene%2C+Mark+H&rft.aulast=Peters&rft.aufirst=June&rft.date=2011-10-01&rft.volume=20&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-011-9370-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Blocking; Relatives; Women; Ovarian cancer; Health; Susceptibility DO - http://dx.doi.org/10.1007/s10897-011-9370-0 ER - TY - JOUR T1 - Coal dust exposure and mortality from ischemic heart disease among a cohort of U.S. coal miners AN - 1017960268; 16691512 AB - Background Particulate exposure from air pollution increases the risk of ischemic heart disease (IHD) mortality. Although coal miners are highly exposed to coal dust particulate, studies of IHD mortality risk among coal miners have had inconsistent results. Previous studies may have been biased by the healthy worker effect. Methods We examined the dose-response relationship between cumulative coal dust exposure, coal rank, and IHD mortality among a cohort of underground coal miners who participated in the National Study of Coal Workers' Pneumoconiosis. Results After adjusting for age, smoking, and body mass index, risk of IHD mortality increased at higher levels of coal dust exposure. Mortality risk was also associated with coal rank region. Conclusion There was an increased risk of mortality from IHD associated with cumulative exposure to coal dust, and with coal rank. The effect of coal rank may be due differences in the composition of coal mine dust particulate. The association of risk of IHD mortality with cumulative particulate exposure is consistent with air pollution studies. Am. J. Ind. Med. 54:727-733, 2011. ? 2011 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Landen, Deborah D AU - Wassell, James T AU - McWilliams, Linda AU - Patel, Ami AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, dlanden@cdc.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 727 EP - 733 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 10 SN - 1097-0274, 1097-0274 KW - Pollution Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Occupational safety KW - Pneumoconiosis KW - Particulates KW - Coal KW - heart diseases KW - Dust KW - Workers KW - Smoking KW - Dose-response effects KW - Occupational exposure KW - Heart diseases KW - Mortality KW - Ischemia KW - Mines KW - Air pollution KW - USA KW - Coal dust KW - Mining KW - Body mass index KW - X 24380:Social Poisons & Drug Abuse KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017960268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Coal+dust+exposure+and+mortality+from+ischemic+heart+disease+among+a+cohort+of+U.S.+coal+miners&rft.au=Landen%2C+Deborah+D%3BWassell%2C+James+T%3BMcWilliams%2C+Linda%3BPatel%2C+Ami&rft.aulast=Landen&rft.aufirst=Deborah&rft.date=2011-10-01&rft.volume=54&rft.issue=10&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20986 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20986/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Pneumoconiosis; Coal; Ischemia; Mines; Dust; Air pollution; Smoking; Workers; Dose-response effects; Coal dust; Body mass index; Occupational exposure; Heart diseases; Occupational safety; Mining; Particulates; heart diseases; USA DO - http://dx.doi.org/10.1002/ajim.20986 ER - TY - JOUR T1 - Temporal Patterns in Work-Related Fatalities Among Foreign-Born Workers in the US, 1992-2007 AN - 1010707564; 201209010 AB - In the United States, approximately 20% of all workers who died on the job in 2007 were foreign-born. The objective of this study was to describe trends in occupational fatalities among foreign-born workers. An analysis of fatal injuries among foreign-born workers in the US occurring from 1992 through 2007 was conducted using the Bureau of Labor Statistics' Census of Fatal Occupational Injuries. Individual characteristics, employment characteristics, injury events and industry employment were summarized and evaluated for trends. Both the number and proportion of foreign-born workers who died from a traumatic work-related injury increased substantially over the time period studied. The proportion who were men, aged 25-44 years, Hispanic, non self-employed, employed by business establishments with 10 or fewer employees, working at private residences and working in Construction and Services consistently increased throughout the time period. While some trends among foreign-born decedents are improving, others are worsening. More comprehensive research efforts are needed to address the occupational injury and safety issues among foreign-born workers, with a focus on Hispanics. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Menendez, Cammie K. Chaumont AU - Havea, Solomone A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-1811, Morgantown, WV, 26505, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 954 EP - 962 PB - Springer, Dordrecht The Netherlands VL - 13 IS - 5 SN - 1557-1912, 1557-1912 KW - Men KW - Industrial accidents KW - Safety KW - Hispanic people KW - Temporal patterns KW - Employment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Temporal+Patterns+in+Work-Related+Fatalities+Among+Foreign-Born+Workers+in+the+US%2C+1992-2007&rft.au=Menendez%2C+Cammie+K.+Chaumont%3BHavea%2C+Solomone+A&rft.aulast=Menendez&rft.aufirst=Cammie+K.&rft.date=2011-10-01&rft.volume=13&rft.issue=5&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-010-9379-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Industrial accidents; Employment; Hispanic people; Safety; Temporal patterns; Men DO - http://dx.doi.org/10.1007/s10903-010-9379-8 ER - TY - JOUR T1 - Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys. AN - 893271870; 21834575 AB - RNA-Seq has been increasingly used for the quantification and characterization of transcriptomes. The ongoing development of the technology promises the more accurate measurement of gene expression. However, its benefits over widely accepted microarray technologies have not been adequately assessed, especially in toxicogenomics studies. The goal of this study is to enhance the scientific community's understanding of the advantages and challenges of RNA-Seq in the quantification of gene expression by comparing analysis results from RNA-Seq and microarray data on a toxicogenomics study. A typical toxicogenomics study design was used to compare the performance of an RNA-Seq approach (Illumina Genome Analyzer II) to a microarray-based approach (Affymetrix Rat Genome 230 2.0 arrays) for detecting differentially expressed genes (DEGs) in the kidneys of rats treated with aristolochic acid (AA), a carcinogenic and nephrotoxic chemical most notably used for weight loss. We studied the comparability of the RNA-Seq and microarray data in terms of absolute gene expression, gene expression patterns, differentially expressed genes, and biological interpretation. We found that RNA-Seq was more sensitive in detecting genes with low expression levels, while similar gene expression patterns were observed for both platforms. Moreover, although the overlap of the DEGs was only 40-50%, the biological interpretation was largely consistent between the RNA-Seq and microarray data. RNA-Seq maintained a consistent biological interpretation with time-tested microarray platforms while generating more sensitive results. However, there is clearly a need for future investigations to better understand the advantages and limitations of RNA-Seq in toxicogenomics studies and environmental health research. JF - Chemical research in toxicology AU - Su, Zhenqiang AU - Li, Zhiguang AU - Chen, Tao AU - Li, Quan-Zhen AU - Fang, Hong AU - Ding, Don AU - Ge, Weigong AU - Ning, Baitang AU - Hong, Huixiao AU - Perkins, Roger G AU - Tong, Weida AU - Shi, Leming AD - ICF International at FDA's National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. zhenqiang.su@fda.hhs.gov Y1 - 2011/09/19/ PY - 2011 DA - 2011 Sep 19 SP - 1486 EP - 1493 VL - 24 IS - 9 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - Index Medicus KW - Rats KW - Animals KW - Carcinogenicity Tests -- methods KW - Gene Expression Regulation -- drug effects KW - Toxicogenetics -- methods KW - Kidney -- metabolism KW - Aristolochic Acids -- toxicity KW - Oligonucleotide Array Sequence Analysis -- methods KW - Kidney -- drug effects KW - Carcinogens -- toxicity KW - Sequence Analysis, RNA -- methods KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893271870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Comparing+next-generation+sequencing+and+microarray+technologies+in+a+toxicological+study+of+the+effects+of+aristolochic+acid+on+rat+kidneys.&rft.au=Su%2C+Zhenqiang%3BLi%2C+Zhiguang%3BChen%2C+Tao%3BLi%2C+Quan-Zhen%3BFang%2C+Hong%3BDing%2C+Don%3BGe%2C+Weigong%3BNing%2C+Baitang%3BHong%2C+Huixiao%3BPerkins%2C+Roger+G%3BTong%2C+Weida%3BShi%2C+Leming&rft.aulast=Su&rft.aufirst=Zhenqiang&rft.date=2011-09-19&rft.volume=24&rft.issue=9&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200103b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-18 N1 - Date created - 2011-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200103b ER - TY - CPAPER T1 - Antibacterial Activity of a Novel Peptide Derived from Phage-Displayed Random Peptide Library T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313050994; 6111081 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Sainath Rao, S. AU - Mohan, K AU - Atreya, C Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Peptide libraries KW - Antibacterial activity KW - Peptides KW - Antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Antibacterial+Activity+of+a+Novel+Peptide+Derived+from+Phage-Displayed+Random+Peptide+Library&rft.au=Sainath+Rao%2C+S.%3BMohan%2C+K%3BAtreya%2C+C&rft.aulast=Sainath+Rao&rft.aufirst=S.&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of an Increase in All-Cause Mortality in Tigecycline Treated Patients T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313016625; 6111130 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Iarikov, D AU - Alexander, J AU - Charles, J AU - Tracy, L AU - Nambiar, S Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Mortality KW - tigecycline UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Analysis+of+an+Increase+in+All-Cause+Mortality+in+Tigecycline+Treated+Patients&rft.au=Iarikov%2C+D%3BAlexander%2C+J%3BCharles%2C+J%3BTracy%2C+L%3BNambiar%2C+S&rft.aulast=Iarikov&rft.aufirst=D&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Enhanced Antimicrobicidal Activity of Peptide-Cocktails against Bacterial Contaminants in Stored Platelets T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313015183; 6111083 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Mohan, K AU - Sainath Rao, S. AU - Atreya, C Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Contaminants KW - Platelets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Enhanced+Antimicrobicidal+Activity+of+Peptide-Cocktails+against+Bacterial+Contaminants+in+Stored+Platelets&rft.au=Mohan%2C+K%3BSainath+Rao%2C+S.%3BAtreya%2C+C&rft.aulast=Mohan&rft.aufirst=K&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats AN - 902377424; 15618173 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2 mu g/kgbw/d (25th-95th percentiles). The current study used LC/MS/MS to measure placental transfer and concentrations of aglycone (receptor-active) and conjugated (inactive) BPA in tissues from Sprague-Dawley rats administered deuterated BPA (100 mu g/kg bw) by oral and IV routes. In adult female rat tissues, the tissue/serum concentration ratios for aglycone BPA ranged from 0.7 in liver to 5 in adipose tissue, reflecting differences in tissue perfusion, composition, and metabolic capacity. Following IV administration to dams, placental transfer was observed for aglycone BPA into fetuses at several gestational days (GD), with fetal/maternal serum ratios of 2.7 at GD 12, 1.2 at GD 16, and 0.4 at GD 20; the corresponding ratios for conjugated BPA were 0.43, 0.65, and 3.7. These ratios were within the ranges observed in adult tissues and were not indicative of preferential accumulation of aglycone BPA or hydrolysis of conjugates in fetal tissue in vivo. Concentrations of aglycone BPA in GD 20 fetal brain were higher than in liver or serum. Oral administration of the same dose did not produce measurable levels of aglycone BPA in fetal tissues. Amniotic fluid consistently contained levels of BPA at or below those in maternal serum. Concentrations of aglycone BPA in tissues of neonatal rats decreased with age in a manner consistent with the corresponding circulating levels. Phase II metabolism of BPA increased with fetal age such that near-term fetus was similar to early post-natal rats. These results show that concentrations of aglycone BPA in fetal tissues are similar to those in other maternal and neonatal tissues and that maternal Phase II metabolism, especially following oral administration, and fetal age are critical in reducing exposures to the fetus. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Brown, Ronald P AU - Fisher, Jeffrey W Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 261 EP - 270 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 255 IS - 3 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Amniotic fluid KW - Age KW - Aglycones KW - Perfusion KW - Food KW - Oral administration KW - Brain KW - Metabolites KW - Plasticity KW - Hydrolysis KW - Fetuses KW - Bisphenol A KW - Placental transfer KW - Urine KW - Liver KW - Adipose tissue KW - Neonates KW - Metabolism KW - polycarbonate KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902377424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Distribution+of+bisphenol+A+into+tissues+of+adult%2C+neonatal%2C+and+fetal+Sprague-Dawley+rats&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BBrown%2C+Ronald+P%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Aglycones; Age; Perfusion; Food; Brain; Oral administration; Metabolites; Plasticity; Hydrolysis; Fetuses; Bisphenol A; Urine; Placental transfer; Liver; Adipose tissue; Neonates; polycarbonate; Metabolism DO - http://dx.doi.org/10.1016/j.taap.2011.07.009 ER - TY - JOUR T1 - Photoirradiation of dehydropyrrolizidine alkaloids--formation of reactive oxygen species and induction of lipid peroxidation. AN - 880998447; 21723383 AB - Pyrrolizidine alkaloid (PA)-containing plants are widespread in the world and are probably the most common poisonous plants affecting livestock, wildlife, and human. PAs require metabolic activation to generate pyrrolic metabolites (dehydro-PAs) that bind cellular protein and DNA, leading to hepatotoxicity and genotoxicity, including tumorigenicity. In this study we report that UVA photoirradiation of a series of dehydro-PAs, e.g., dehydromonocrotaline, dehydroriddelliine, dehydroretrorsine, dehydrosenecionine, dehydroseneciphylline, dehydrolasiocarpine, dehydroheliotrine, and dehydroretronecine (DHR) at 0-70 J/cm2 in the presence of a lipid, methyl linoleate, resulted in lipid peroxidation in a light dose-responsive manner. When irradiated in the presence of sodium azide, the level of lipid peroxidation decreased; lipid peroxidation was enhanced when methanol was replaced by deuterated methanol. These results suggest that singlet oxygen is a photo-induced product. When irradiated in the presence of superoxide dismutase, the level of lipid peroxidation decreased, indicating that lipid peroxidation is also mediated by superoxide. Electron spin resonance (ESR) spin trapping studies confirmed that both singlet oxygen and superoxide anion radical were formed during photoirradiation. These results indicate that UVA photoirradiation of dehydro-PAs generates reactive oxygen species (ROS) that mediated the initiation of lipid peroxidation. UVA irradiation of the parent PAs and other PA metabolites, including PA N-oxides, under similar experimental conditions did not produce lipid peroxidation. It is known that PAs induce skin cancer and are secondary (hepatogenous) photosensitization agents. Our results suggest that dehydro-PAs are the active metabolites responsible for skin cancer formation and PA-induced secondary photosensitization. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Zhao, Yuewei AU - Xia, Qingsu AU - Yin, Jun Jie AU - Lin, Ge AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/09/10/ PY - 2011 DA - 2011 Sep 10 SP - 302 EP - 309 VL - 205 IS - 3 KW - Carcinogens KW - 0 KW - Indicators and Reagents KW - Linoleic Acids KW - Lipid Peroxides KW - Pyrrolizidine Alkaloids KW - Reactive Oxygen Species KW - Solvents KW - Superoxides KW - 11062-77-4 KW - Singlet Oxygen KW - 17778-80-2 KW - methyl linoleate KW - 24N6726DE5 KW - methyl linoleate hydroperoxide KW - 27323-65-5 KW - Sodium Azide KW - 968JJ8C9DV KW - Deuterium KW - AR09D82C7G KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione KW - GAN16C9B8O KW - Methanol KW - Y4S76JWI15 KW - Index Medicus KW - Linoleic Acids -- radiation effects KW - Ultraviolet Rays KW - Superoxide Dismutase -- metabolism KW - Linoleic Acids -- chemistry KW - Singlet Oxygen -- chemistry KW - Superoxides -- chemistry KW - Superoxides -- metabolism KW - Spin Trapping KW - Solvents -- chemistry KW - Sodium Azide -- chemistry KW - Electron Spin Resonance Spectroscopy KW - Kinetics KW - Glutathione -- chemistry KW - Indicators and Reagents -- chemistry KW - Methanol -- chemistry KW - Glutathione -- analogs & derivatives KW - Carcinogens -- radiation effects KW - Carcinogens -- chemistry KW - Lipid Peroxides -- chemistry KW - Carcinogens -- toxicity KW - Reactive Oxygen Species -- chemistry KW - Pyrrolizidine Alkaloids -- toxicity KW - Pyrrolizidine Alkaloids -- radiation effects KW - Pyrrolizidine Alkaloids -- chemistry KW - Lipid Peroxides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880998447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Photoirradiation+of+dehydropyrrolizidine+alkaloids--formation+of+reactive+oxygen+species+and+induction+of+lipid+peroxidation.&rft.au=Zhao%2C+Yuewei%3BXia%2C+Qingsu%3BYin%2C+Jun+Jie%3BLin%2C+Ge%3BFu%2C+Peter+P&rft.aulast=Zhao&rft.aufirst=Yuewei&rft.date=2011-09-10&rft.volume=205&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2011.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-05 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2011.06.020 ER - TY - JOUR T1 - Performance comparison of three types of high-speed counter-current chromatographs for the separation of components of hydrophilic and hydrophobic color additives AN - 1266752957; 15591076 AB - The performance of three types of high-speed counter-current chromatography (HSCCC) instruments was assessed for their use in separating components in hydrophilic and hydrophobic dye mixtures. The HSCCC instruments compared were: (i) a J-type coil planet centrifuge (CPC) system with a conventional multilayer-coil column, (ii) a J-type CPC system with a spiral-tube assembly-coil column, and (iii) a cross-axis CPC system with a multilayer-coil column. The hydrophilic dye mixture consisted of a sample of FD&C Blue No. 2 that contained mainly two isomeric components, 5,5'- and 5,7'-disulfonated indigo, in the ratio of [not, vert, similar]7:1. The hydrophobic dye mixture consisted of a sample of D&C Red No. 17 (mainly Sudan III) and Sudan II in the ratio of [not, vert, similar]4:1. The two-phase solvent systems used for these separations were 1-butanol/1.3 M HCl and hexane/acetonitrile. Each of the three instruments was used in two experiments for the hydrophilic dye mixture and two for the hydrophobic dye mixture, for a total of 12 experiments. In one set of experiments, the lower phase was used as the mobile phase, and in the second set of experiments, the upper phase was used as the mobile phase. The results suggest that: (a) use of a J-type instrument with either a multilayer-coil column or a spiral-tube assembly column, applying the lower phase as the mobile phase, is preferable for separating the hydrophilic components of FD&C Blue No. 2; and (b) use of a J-type instrument with multilayer-coil column, while applying either the upper phase or the lower phase as the mobile phase, is preferable for separating the hydrophobic dye mixture of D&C Red No. 17 and Sudan II. JF - Journal of Chromatography A AU - Weisz, Adrian AU - Ito, Yoichiro Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6156 EP - 6164 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - High-speed counter-current chromatography KW - J-type coil planet centrifuge KW - Cross-axis coil planet centrifuge KW - Multilayer-coil column KW - Spiral-tube assembly column KW - HPLC KW - Color additives KW - FD&C Blue No. 2 KW - D&C Red No. 17 KW - Sudan II KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Sudan KW - Color KW - Colour KW - Performance Evaluation KW - Analytical Methods KW - Centrifuges KW - Additives KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Performance+comparison+of+three+types+of+high-speed+counter-current+chromatographs+for+the+separation+of+components+of+hydrophilic+and+hydrophobic+color+additives&rft.au=Weisz%2C+Adrian%3BIto%2C+Yoichiro&rft.aulast=Weisz&rft.aufirst=Adrian&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.12.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Colour; Centrifuges; Chromatographic techniques; Solvents; Additives; Performance Evaluation; Chromatography; Analytical Methods; Color; Sudan DO - http://dx.doi.org/10.1016/j.chroma.2010.12.034 ER - TY - JOUR T1 - Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter. AN - 880715004; 21708214 AB - Welding results in a unique and complex occupational exposure. Recent epidemiological studies have shown an increased risk of cardiovascular disease following welding fume exposure. In this study, we compared the induction of pulmonary and systemic inflammation following exposure to multiple types of welding fumes. Mice were exposed to 340μg of manual metal arc stainless steel (MMA-SS), gas metal arc-SS (GMA-SS) or GMA-mild steel (GMA-MS) by pharyngeal aspiration. Mice were sacrificed at 4 and 24h post-exposure to evaluate various parameters of pulmonary and systemic inflammation. Alterations in pulmonary gene expression by a custom designed TaqMan array showed minimal differences between the fumes at 4h. Conversely at 24h, gene expression changes were further increased by SS but not GMA-MS exposure. These findings were associated with the surrogate marker of systemic inflammation, liver acute phase gene induction. Interestingly, stress response genes in cardiovascular tissues were only increased following MMA-SS exposure. These effects were related to the initial level of pulmonary cytotoxicity, as measured by lactate dehydrogenase activity, which was greatest following MMA-SS exposure. In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Erdely, Aaron AU - Salmen-Muniz, Rebecca AU - Liston, Angie AU - Hulderman, Tracy AU - Zeidler-Erdely, Patti C AU - Antonini, James M AU - Simeonova, Petia P AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, United States. efi4@cdc.gov Y1 - 2011/09/05/ PY - 2011 DA - 2011 Sep 05 SP - 153 EP - 159 VL - 287 IS - 1-3 KW - Biomarkers KW - 0 KW - Particulate Matter KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Bronchoalveolar Lavage Fluid -- chemistry KW - RNA, Messenger -- analysis KW - Mice, Inbred C57BL KW - Cardiovascular System -- metabolism KW - Mice KW - Cardiovascular System -- drug effects KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Particulate Matter -- toxicity KW - Inflammation -- chemically induced KW - Lung -- drug effects KW - Welding KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880715004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Relationship+between+pulmonary+and+systemic+markers+of+exposure+to+multiple+types+of+welding+particulate+matter.&rft.au=Erdely%2C+Aaron%3BSalmen-Muniz%2C+Rebecca%3BListon%2C+Angie%3BHulderman%2C+Tracy%3BZeidler-Erdely%2C+Patti+C%3BAntonini%2C+James+M%3BSimeonova%2C+Petia+P&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2011-09-05&rft.volume=287&rft.issue=1-3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-30 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2011.06.008 ER - TY - JOUR T1 - Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats AN - 926891879; 16401676 AB - The use of cerium compounds as diesel fuel catalyst results in the emission of cerium oxide nanoparticles (CeO sub(2)) in the exhaust. This study characterized the potential effects of CeO sub(2) exposure on lung toxicity. Male Sprague Dawley rats were exposed to CeO sub(2) by a single intratracheal instillation at 0.15, 0.5, 1, 3.5 or 7 mg/kg body weight. At 1 day after exposure, CeO sub(2) significantly reduced NO production, but increased IL-12 production, by alveolar macrophages (AM) in response to ex vivo lipopolysacchride (LPS) challenge, and caused AM apoptosis, through activation of caspases 9 and 3. CeO sub(2) exposure markedly increased suppressor of cytokine signaling-1 at 1-day and elevated arginase-1 at 28-day post exposure in lung cells, while osteopontin was significantly elevated in lung tissue at both time points. CeO sub(2) induced inflammation, cytotoxicity, air/blood barrier damage, and phospholipidosis with enlarged AM. Thus, CeO sub(2) induced lung inflammation and injury in lungs which may lead to fibrosis. JF - Nanotoxicology AU - Ma, J Y AU - Zhao, H AU - Mercer, R R AU - Barger, M AU - Rao, M AU - Meighan, T AU - Schwegler-Berry, D AU - Castranova, V AU - Ma, J K AD - PPRB/HELD, NIOSH, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, USA, iym1@cdc.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 312 EP - 325 VL - 5 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Alveoli KW - Lung KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Cerium+oxide+nanoparticle-induced+pulmonary+inflammation+and+alveolar+macrophage+functional+change+in+rats&rft.au=Ma%2C+J+Y%3BZhao%2C+H%3BMercer%2C+R+R%3BBarger%2C+M%3BRao%2C+M%3BMeighan%2C+T%3BSchwegler-Berry%2C+D%3BCastranova%2C+V%3BMa%2C+J+K&rft.aulast=Ma&rft.aufirst=J&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.519835 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Lung DO - http://dx.doi.org/10.3109/17435390.2010.519835 ER - TY - JOUR T1 - Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators AN - 926891872; 16401674 AB - More information characterizing the biological responses to nanoparticles is needed to allow the U.S. Food and Drug Administration to evaluate the safety and effectiveness of products with nano-scale components. The potential cytotoxicity and inflammatory responses of Au NPs (60 nm, NIST standard reference materials) were investigated in murine macrophages. Cytotoxicity was evaluated by MTT and LDH assays. Cytokines (IL-6, TNF- alpha ), nitric oxide, and ROS were assayed to assess inflammatory responses. Morphological appearance and localization of particles were examined by high resolution illumination microscopy, transmission electron microscopy (TEM), and scanning TEM coupled with EDX spectroscopy. Results showed no cytotoxicity and no elevated production of proinflammatory mediators; however, imaging analyses demonstrated cellular uptake of Au NPs and localization within intracellular vacuoles. These results suggest that 60 nm Au NPs, under the exposure conditions tested, are not cytotoxic, nor elicit pro-inflammatory responses. The localization of Au NPs in intracellular vacuoles suggests endosomal containment and an uptake mechanism involving endocytosis. JF - Nanotoxicology AU - Zhang, Q AU - Hitchins, V M AU - Schrand, A M AU - Hussain, S M AU - Goering, P L AD - Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Ave, Bldg 64, Rm 4064, Silver Spring, MD 20993, USA, peter.goering@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 284 EP - 295 VL - 5 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Cytotoxicity KW - Inflammation KW - F 06960:Molecular Immunology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Uptake+of+gold+nanoparticles+in+murine+macrophage+cells+without+cytotoxicity+or+production+of+pro-inflammatory+mediators&rft.au=Zhang%2C+Q%3BHitchins%2C+V+M%3BSchrand%2C+A+M%3BHussain%2C+S+M%3BGoering%2C+P+L&rft.aulast=Zhang&rft.aufirst=Q&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.512401 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Inflammation DO - http://dx.doi.org/10.3109/17435390.2010.512401 ER - TY - JOUR T1 - Symptoms of Infectious Diseases in Immunocompromised Travelers: A Prospective Study With Matched Controls AN - 911154313; 15994660 AB - Background. Immunocompromised travelers to developing countries are thought to have symptomatic infectious diseases more often and longer than non-immunocompromised travelers. Evidence for this is lacking. This study evaluates whether immunocompromised short-term travelers are at increased risk of diseases. Methods. A prospective study was performed between October 2003 and May 2010 among adult travelers using immunosuppressive agents (ISA) and travelers with inflammatory bowel disease (IBD), with their non-immunocompromised travel companions serving as matched controls with comparable exposure to infection. Data on symptoms of infectious diseases were recorded by using a structured diary. Results. Among 75 ISA, the incidence of travel-related diarrhea was 0.76 per person-month, and the number of symptomatic days 1.32 per month. For their 75 controls, figures were 0.66 and 1.50, respectively (p > 0.05). Among 71 IBD, the incidence was 1.19, and the number of symptomatic days was 2.48. For their 71 controls, figures were 0.73 and 1.31, respectively (p > 0.05). These differences also existed before travel. ISA had significantly more and longer travel-related signs of skin infection and IBD suffered more and longer from vomiting. As for other symptoms, no significant travel-related differences were found. Only 21% of immunocompromised travelers suffering from diarrhea used their stand-by antibiotics. Conclusions. ISA and IBD did not have symptomatic infectious diseases more often or longer than non-immunocompromised travelers, except for signs of travel-related skin infection among ISA. Routine prescription of stand-by antibiotics for these immunocompromised travelers to areas with good health facilities is probably not more useful than for healthy travelers. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Geskus, Ronald B AU - Kint, Joan A AU - Roukens, Anna HE AU - Sonder, Gerard J AU - van den Hoek, Anneke AD - Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 318 EP - 326 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 18 IS - 5 SN - 1195-1982, 1195-1982 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Risk Abstracts KW - Travel KW - Symptoms KW - Skin KW - Fish diseases KW - Infectious diseases KW - infection KW - Antibiotics KW - Developing countries KW - Q1 08625:Non-edible products KW - Q5 08504:Effects on organisms KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Symptoms+of+Infectious+Diseases+in+Immunocompromised+Travelers%3A+A+Prospective+Study+With+Matched+Controls&rft.au=Baaten%2C+Gijs+G%3BGeskus%2C+Ronald+B%3BKint%2C+Joan+A%3BRoukens%2C+Anna+HE%3BSonder%2C+Gerard+J%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2011-09-01&rft.volume=18&rft.issue=5&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2011.00543.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Symptoms; Infectious diseases; Fish diseases; Antibiotics; Developing countries; Travel; Skin; infection DO - http://dx.doi.org/10.1111/j.1708-8305.2011.00543.x ER - TY - JOUR T1 - Personality and Obesity Across the Adult Life Span AN - 908021642; 201122471 AB - Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adiposity and with fluctuations in body mass index (BMI). Using 14,531 anthropometric assessments, the authors modeled the trajectory of BMI across adulthood and tested whether personality predicted its rate of change. Measured concurrently, participants higher on Neuroticism or Extraversion or lower on Conscientiousness had higher BMI; these associations replicated across body fat, waist, and hip circumference. The strongest association was found for the impulsivity facet: Participants who scored in the top 10% of impulsivity weighed, on average, 11Kg more than those in the bottom 10%. Longitudinally, high Neuroticism and low Conscientiousness, and the facets of these traits related to difficulty with impulse control, were associated with weight fluctuations, measured as the variability in weight over time. Finally, low Agreeableness and impulsivity-related traits predicted a greater increase in BMI across the adult life span. BMI was mostly unrelated to change in personality traits. Personality traits are defined by cognitive, emotional, and behavioral patterns that likely contribute to unhealthy weight and difficulties with weight management. Such associations may elucidate the role of personality traits in disease progression and may help to design more effective interventions. [Copyright The American Psychological Association.] JF - Journal of Personality and Social Psychology AU - Sutin, Angelina R AU - Ferrucci, Luigi AU - Zonderman, Alan B AU - Terracciano, Antonio AD - National Institute on Aging, National Institutes of Health (NIH), and Department of Health and Human Services sutina@mail.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 579 EP - 592 PB - American Psychological Association, Washington DC VL - 101 IS - 3 SN - 0022-3514, 0022-3514 KW - obesity body mass index five-factor model personality weight gain KW - Neuroticism KW - Life span KW - Personality KW - Conscientiousness KW - Body Mass Index KW - Fluctuations KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908021642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Personality+and+Social+Psychology&rft.atitle=Personality+and+Obesity+Across+the+Adult+Life+Span&rft.au=Sutin%2C+Angelina+R%3BFerrucci%2C+Luigi%3BZonderman%2C+Alan+B%3BTerracciano%2C+Antonio&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-09-01&rft.volume=101&rft.issue=3&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+Personality+and+Social+Psychology&rft.issn=00223514&rft_id=info:doi/10.1037%2Fa0024286 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPSPB2 N1 - SubjectsTermNotLitGenreText - Personality; Body Mass Index; Fluctuations; Life span; Neuroticism; Conscientiousness DO - http://dx.doi.org/10.1037/a0024286 ER - TY - JOUR T1 - Opening Up Their Doors: Perspectives on the Involvement of the African American Faith Community in HIV Prevention in Four Communities AN - 908021621; 201122618 AB - In 1998, the U.S. government launched the Minority AIDS Initiative (MAI) to address growing ethnic and racial disparities in HIV/AIDS cases. The CDC performed an evaluation of its MAI-funded programs, including an assessment of community stakeholders' perspective on the involvement of the faith community in HIV prevention. Individual interviews (N = 113) were conducted annually over 3 years in four communities. The majority of participants described a change in faith community's attitudes toward HIV and a rise in HIV-related activities conducted by faith-based organizations. Participants attributed changes to faith-based funding, acknowledgment by African American community leadership that HIV is a serious health issue, and faith leaders' desire to become more educated on HIV/AIDS. Participants reported conservative faith doctrine and stigma as barriers to faith community involvement. The findings suggest that although barriers remain, there is an increased willingness to address HIV/AIDS, and the faith community serves as a vital resource in HIV prevention. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Promotion Practice AU - Wooster, Joanna AU - Eshel, Ariela AU - Moore, Andrea AU - Mishra, Meenoo AU - Toledo, Carlos AU - Uhl, Gary AU - Wright-De Aguero, Linda AD - Centers for Disease Control and Prevention, Department of Health and Human Services in Atlanta, Georgia Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 769 EP - 778 PB - Sage Publications, Thousand Oaks CA VL - 12 IS - 5 SN - 1524-8399, 1524-8399 KW - HIV prevention Minority AIDS Initiative community stakeholders qualitative capacity KW - Black American people KW - Religious communities KW - Acknowledgment KW - HIV KW - Minority groups KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908021621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Opening+Up+Their+Doors%3A+Perspectives+on+the+Involvement+of+the+African+American+Faith+Community+in+HIV+Prevention+in+Four+Communities&rft.au=Wooster%2C+Joanna%3BEshel%2C+Ariela%3BMoore%2C+Andrea%3BMishra%2C+Meenoo%3BToledo%2C+Carlos%3BUhl%2C+Gary%3BWright-De+Aguero%2C+Linda&rft.aulast=Wooster&rft.aufirst=Joanna&rft.date=2011-09-01&rft.volume=12&rft.issue=5&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/10.1177%2F1524839910362313 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-12-01 N1 - Number of references - 44 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - HIV; Religious communities; Preventive programmes; Black American people; Minority groups; Acknowledgment DO - http://dx.doi.org/10.1177/1524839910362313 ER - TY - JOUR T1 - Monoclonal antibodies against the leptospiral immunoglobulin-like proteins A and B conserved regions AN - 907190787; 15792965 AB - Leptospirosis is an infectious disease caused by pathogenic spirochetes of the genus Leptospira that affects humans and a wide variety of animals. Recently the genomes of Leptospira interrogans, Leptospira borgpetersenii and Leptospira biflexa species were sequenced allowing the identification of new virulence factors involved in survival and pathogenesis of bacteria. LigA and LigB are surface-exposed bacterial adhesins whose expression is correlated with the virulence of Leptospira strains. In this study, we produced and characterized five monoclonal antibodies (MAbs) against a recombinant fragment of LigB (rLigBrep) with approximately 54 kDa that comprise the portions of LigA and LigB (domains 2-7). The 5 MAbs obtained were of the IgG1 (2) and IgG2b (3) isotypes and their affinity constants for rLigBrep ranged from 7 x 10 super(7 M) super(-)1 to 4 x 10 super(8 M) super(-)1. The MAbs were able to react with the native antigen on the L. interrogans, L. borgpetersenii and Leptospira noguchii surfaces by indirect immunofluorescence, immunoblotting and immunoelectron microscopy. These results demonstrate that the MAbs anti-rLigBrep can be useful to complement genetic studies and to aid studies aiming understanding the role of Lig proteins in Leptospira pathogenesis and the development of Lig-based vaccines and improved diagnostic tests for leptospirosis. JF - Comparative Immunology, Microbiology and Infectious Diseases AU - Monte, Leonardo G AU - Conceicao, Fabricio R AU - Coutinho, Mariana L AU - Seixas, Fabiana K AU - Silva, Everton Fda AU - Vasconcellos, Flavia A AU - DeCastro, Luis AS AU - Hartleben, Claudia P AU - Dellagostin, Odir A AU - Aleixo, Jose AG AD - Laboratorio de Imunologia Aplicada, Nucleo de Biotecnologia, Centro de Desenvolvimento Tecnologico, Universidade Federal de Pelotas, P.O. Box 354, 96010-900, Pelotas, RS, Brazil, leonardogmonte@hotmail.com Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 441 EP - 446 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 34 IS - 5 SN - 0147-9571, 0147-9571 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Leptospira KW - Ligs KW - Monoclonal antibodies KW - Genomes KW - Adhesins KW - virulence factors KW - Leptospira borgpetersenii KW - Survival KW - Immunoelectron microscopy KW - Virulence KW - Antigens KW - Infectious diseases KW - Leptospira interrogans KW - Immunoblotting KW - Leptospirosis KW - Leptospira biflexa KW - Immunofluorescence KW - Recombinants KW - Spirochetes KW - Microbiology KW - Immunoglobulin G KW - Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907190787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+Immunology%2C+Microbiology+and+Infectious+Diseases&rft.atitle=Monoclonal+antibodies+against+the+leptospiral+immunoglobulin-like+proteins+A+and+B+conserved+regions&rft.au=Monte%2C+Leonardo+G%3BConceicao%2C+Fabricio+R%3BCoutinho%2C+Mariana+L%3BSeixas%2C+Fabiana+K%3BSilva%2C+Everton+Fda%3BVasconcellos%2C+Flavia+A%3BDeCastro%2C+Luis+AS%3BHartleben%2C+Claudia+P%3BDellagostin%2C+Odir+A%3BAleixo%2C+Jose+AG&rft.aulast=Monte&rft.aufirst=Leonardo&rft.date=2011-09-01&rft.volume=34&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Comparative+Immunology%2C+Microbiology+and+Infectious+Diseases&rft.issn=01479571&rft_id=info:doi/10.1016%2Fj.cimid.2011.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Genomes; Recombinants; Virulence; Antigens; Infectious diseases; Monoclonal antibodies; Microbiology; Immunofluorescence; Vaccines; Adhesins; Immunoblotting; virulence factors; Leptospirosis; Survival; Immunoelectron microscopy; Spirochetes; Immunoglobulin G; Leptospira interrogans; Leptospira borgpetersenii; Leptospira biflexa DO - http://dx.doi.org/10.1016/j.cimid.2011.08.003 ER - TY - JOUR T1 - Animal models to assess the toxicity, immunogenicity and effectiveness of candidate influenza vaccines AN - 902377392; 15815367 AB - Introduction: Every year, > 100 million doses of licensed influenza vaccine are administered worldwide, with relatively few serious adverse events reported. Initiatives to manufacture influenza vaccines on different platforms have come about to ensure timely production of strain-specific as well as universal vaccines. To prevent adverse events that may be associated with these new vaccines, it is important to evaluate the toxicity of new formulations in animal models. Areas covered: This review outlines preclinical studies that evaluate safety, immunogenicity and effectiveness of novel products to support further development and clinical trials. This has been done through a review of the latest literature describing vaccines under development. Expert opinion: The objective of preclinical safety tests is to demonstrate the absence of toxic contaminants and adventitious agents. Additional tests that characterize vaccine content more completely, or demonstrate the absence of exacerbated disease following virus challenge in vaccinated animals, may provide additional data to ensure the safety of new vaccine strategies. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Eichelberger, Maryna C AU - Green, Martin D AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA ++1 301 402 3846; ++1 301 496 1810, Maryna.Eichelberger@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1117 EP - 1127 PB - Informa Healthcare VL - 7 IS - 9 SN - 1742-5255, 1742-5255 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Influenza KW - Data processing KW - Immunogenicity KW - Reviews KW - Animal models KW - Vaccines KW - Toxicity KW - Contaminants KW - Clinical trials KW - V 22350:Immunology KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902377392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Animal+models+to+assess+the+toxicity%2C+immunogenicity+and+effectiveness+of+candidate+influenza+vaccines&rft.au=Eichelberger%2C+Maryna+C%3BGreen%2C+Martin+D&rft.aulast=Eichelberger&rft.aufirst=Maryna&rft.date=2011-09-01&rft.volume=7&rft.issue=9&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.2011.602065 L2 - http://www.ingentaconnect.com/content/apl/emt/2011/00000007/00000009/art00005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Influenza; Data processing; Immunogenicity; Reviews; Animal models; Toxicity; Vaccines; Contaminants; Clinical trials DO - http://dx.doi.org/10.1517/17425255.2011.602065 ER - TY - JOUR T1 - Assessing the toxicity of polymeric food-contact substances AN - 902366946; 15552518 AB - The US Food and Drug Administration's Office of Food Additive Safety in the Center for Food Safety and Applied Nutrition conducts safety assessments of food additives, including food-contact substances such as polymeric and oligomeric materials that have the potential to migrate to food. Traditionally, little toxicity testing has been conducted on the low-molecular weight oligomeric fraction (<1000Da) of these food-contact substances. At lower exposures (a[copy1/2150 mu g/person/day), safety has been assessed based on the use of toxicity data on the monomeric components of these polymers as a sufficiently conservative approach for addressing the concern for genetic toxicity and carcinogenicity of the low-molecular weight oligomers (LMWOs). This paper discusses this assumption relative to the available data on these substances and their monomeric components in the context of exposures of a[copy1/2150 mu g/person/day with emphasis on the evaluation of the potential genetic toxicity of these compounds. In most instances, data are available on either the monomers or the monomers' structural class to conservatively address the potential genetic toxicity of the LMWOs. Caveats to this generalization are also discussed. The assessment of LMWOs is important because they can be one of the primary migrants to food from a polymeric food-contact substance. JF - Food and Chemical Toxicology AU - Nelson, Chad P AU - Patton, Geoffrey W AU - Arvidson, Kirk AU - Lee, Helen AU - Twaroski, Michelle L Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1877 EP - 1897 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 49 IS - 9 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Food-contact substance KW - Polymers KW - Oligomers KW - Regulatory KW - Toxicology KW - Monomers KW - Food additives KW - Data processing KW - Carcinogenicity KW - Toxicity KW - Migration KW - Nutrition KW - Toxicity testing KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902366946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Assessing+the+toxicity+of+polymeric+food-contact+substances&rft.au=Nelson%2C+Chad+P%3BPatton%2C+Geoffrey+W%3BArvidson%2C+Kirk%3BLee%2C+Helen%3BTwaroski%2C+Michelle+L&rft.aulast=Nelson&rft.aufirst=Chad&rft.date=2011-09-01&rft.volume=49&rft.issue=9&rft.spage=1877&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2011.06.054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Monomers; Food additives; Data processing; Carcinogenicity; Toxicity; Toxicity testing; Nutrition; Migration DO - http://dx.doi.org/10.1016/j.fct.2011.06.054 ER - TY - JOUR T1 - Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey AN - 902353997; 15763075 AB - The combination of nitrous oxide gas (N2O) and isoflurane (ISO) vapor is commonly used in pediatric surgical procedures for human infants and children to produce unconsciousness and analgesia. Because of obvious limitations it is difficult to thoroughly explore the effects of pediatric anesthetic agents on neurons in human infants or children. Due to the complexity of the primate brain, the monkey is often the animal model of choice for developmental neurotoxicology experiments, and it is in the rhesus monkey that the phenomenon of interest (anesthetic-induced neuronal cell death in the brain) has been previously reported. Recent reports indicate that exposure of the developing brain to general anesthetics that block N-methyl-d-aspartate (NMDA)-type glutamate receptors or potentiate gamma-aminobutyric acid (GABA) receptors can trigger widespread apoptotic cell death in rodents. The present study was performed to determine whether prolonged exposure of developing nonhuman primates to a clinically relevant combination of nitrous oxide and isoflurane produces neuronal damage. Postnatal day (PND) 5-6 rhesus monkeys were exposed to N2O (70%) or ISO (1.0%) alone, or N2O plus ISO for 8h. Inhalation of the combination of 70% N2O+1% ISO produces a surgical plane of anesthesia. Six hours after completion of anesthetic administration the monkeys were examined for neurotoxic effects. No significant neurotoxic effects were observed for the monkeys exposed to N2O or ISO alone. However, neuronal damage was apparent when N2O was combined with ISO as indicated by increased numbers of caspase-3-, Silver staining- and Fluoro-Jade C-positive cells in the frontal cortex, temporal gyrus and hippocampus. Electron micrographs indicated typical swelling of the cytoplasm and nuclear condensation in the frontal cortex. These data suggest that prolonged exposure to inhaled anesthetics (a combination of N2O and ISO) in the developing rhesus monkey results in neuronal damage, and that the cell death observed is apoptotic and necrotic in nature. JF - Neurotoxicology and Teratology AU - Zou, Xiaoju AU - Liu, Fang AU - Zhang, Xuan AU - Patterson, Tucker A AU - Callicott, Ralph AU - Liu, Shuliang AU - Hanig, Joseph P AU - Paule, Merle G AU - Slikker, William AU - Wang, Cheng Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 592 EP - 597 PB - Elsevier B.V., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 33 IS - 5 SN - 0892-0362, 0892-0362 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Inhalation KW - N-Methyl-D-aspartic acid receptors KW - Apoptosis KW - Pediatrics KW - gamma -Aminobutyric acid KW - Brain KW - Cortex (frontal) KW - Anesthetics KW - Cortex (temporal) KW - Children KW - Primates KW - Glutamic acid receptors KW - gamma -Aminobutyric acid receptors KW - Cell death KW - Analgesia KW - Anesthesia KW - Nitrous oxide KW - Neurotoxicity KW - Isoflurane KW - Macaca mulatta KW - Infants KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902353997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Inhalation+anesthetic-induced+neuronal+damage+in+the+developing+rhesus+monkey&rft.au=Zou%2C+Xiaoju%3BLiu%2C+Fang%3BZhang%2C+Xuan%3BPatterson%2C+Tucker+A%3BCallicott%2C+Ralph%3BLiu%2C+Shuliang%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BWang%2C+Cheng&rft.aulast=Zou&rft.aufirst=Xiaoju&rft.date=2011-09-01&rft.volume=33&rft.issue=5&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2011.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Inhalation; N-Methyl-D-aspartic acid receptors; Apoptosis; Pediatrics; gamma -Aminobutyric acid; Brain; Anesthetics; Cortex (frontal); Cortex (temporal); Children; Glutamic acid receptors; gamma -Aminobutyric acid receptors; Analgesia; Cell death; Anesthesia; Nitrous oxide; Neurotoxicity; Isoflurane; Infants; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.ntt.2011.06.003 ER - TY - JOUR T1 - Efficacy of the Revised NIOSH Lifting Equation to Predict Risk of Low Back Pain Due to Manual Lifting Expanded Cross-Sectional Analysis AN - 899164280; 15775772 AB - Objective: To evaluate whether the Revised NIOSH Lifting Equation (RNLE) is a valid tool for assessing risk of low back pain (LBP) due to manual lifting by using combined data from two cross-sectional studies of 1-year prevalence. Methods: Results from a symptom and occupational history questionnaire and RNLE analysis for 677 subjects employed in 125 manual lifting jobs at nine industrial sites were combined from two studies. Results: The odds of LBP increased as the lifting index (LI) increased from 1.0 to 3.0. A statistically significant odds ratio (OR) was found for both the 1 < LI less than or equal to 2 (OR = 1.81) and the 2 < LI less than or equal to 3 categories (OR = 2.26). For jobs with an LI value greater than 3.0, however, the OR remained nonsignificant. The 2 < LI less than or equal to 3 group remained statistically significant after adjusting for age, gender, body mass index, and psychosocial factors. Conclusions: It is clear that as the LI increases, the risk of LBP increases. Longitudinal studies are needed. JF - Journal of Occupational and Environmental Medicine AU - Waters, T R AU - Lu, M-L AU - Piacitelli, LA AU - Werren, D AU - Deddens, JA AD - NIOSH (C24), 4676 Columbia Parkway, Cincinnati, OH 45226, USA, trw1@cdc.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1061 EP - 1067 VL - 53 IS - 9 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - low back pain KW - body mass KW - Gender KW - lifting KW - longitudinal studies KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899164280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Efficacy+of+the+Revised+NIOSH+Lifting+Equation+to+Predict+Risk+of+Low+Back+Pain+Due+to+Manual+Lifting+Expanded+Cross-Sectional+Analysis&rft.au=Waters%2C+T+R%3BLu%2C+M-L%3BPiacitelli%2C+LA%3BWerren%2C+D%3BDeddens%2C+JA&rft.aulast=Waters&rft.aufirst=T&rft.date=2011-09-01&rft.volume=53&rft.issue=9&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31822cfe5e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Age; body mass; Gender; low back pain; lifting; longitudinal studies DO - http://dx.doi.org/10.1097/JOM.0b013e31822cfe5e ER - TY - JOUR T1 - Trends in Work-Related Musculoskeletal Disorders A Comparison of Risk Factors for Symptoms Using Quality of Work Life Data From the 2002 and 2006 General Social Survey AN - 899164250; 15775766 AB - Objective: To assess trends in risk factors for work-related musculoskeletal disorders (MSDs). Methods: Results from two similar national surveys (2002 and 2006) examined trends in relationships between individual, psy-chosocial, and physical factors and MSDs. Results: Findings between years were similar, but important differences included a stronger effect of "Work Stress" on "Pain in Arms," and a stronger combined effect of "Hand Movement" and "Work Stress" on "Pain in Arms." Also, two interactions were statistically significant in the 2006 data, but not in the 2002 data, revealing potentially increased risks. These were "Hand Movement" and "Work Stress" on "Back Pain," and "Heavy Lifting" and "Work Stress" on "Pain in Arms." Conclusion: New strategies for preventing both low back and upper extremity MSDs should focus on work stress, heavy lifting, and hand movement, individually and in combination. JF - Journal of Occupational and Environmental Medicine AU - Waters, T R AU - Dick, R B AU - Krieg, E F AD - Division of Applied Research and Technology, NIOSH, Mail-Stop C-24, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, TRW1@cdc.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1013 EP - 1024 VL - 53 IS - 9 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational health KW - Risk factors KW - Stress KW - back pain KW - lifting KW - musculoskeletal system KW - pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899164250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Trends+in+Work-Related+Musculoskeletal+Disorders+A+Comparison+of+Risk+Factors+for+Symptoms+Using+Quality+of+Work+Life+Data+From+the+2002+and+2006+General+Social+Survey&rft.au=Waters%2C+T+R%3BDick%2C+R+B%3BKrieg%2C+E+F&rft.aulast=Waters&rft.aufirst=T&rft.date=2011-09-01&rft.volume=53&rft.issue=9&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181fc8493 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Risk factors; pain; Stress; back pain; lifting; musculoskeletal system; Occupational health DO - http://dx.doi.org/10.1097/JOM.0b013e3181fc8493 ER - TY - JOUR T1 - Post-mortem toxicological urine screening in cause of death determination AN - 899155332; 15630134 AB - This study evaluated standard toxicology screening by forensic physicians during external post-mortem examination. Collected urine samples of decedents were screened on-site for the presence of 10 commonly used drugs by means of a rapid multidrug test. Urine samples of 53% of the cases appeared to be positive for one or more compounds. Importantly, several cases were revealed which were positive for toxicology screening without indications for use of these drugs at the scene of death or from medical history. Based on these (preliminary) results, further action to incorporate routine post-mortem toxicology as a tool in forensic death investigation is recommended. JF - Human & Experimental Toxicology AU - Ceelen, Manon AU - Dorn, Tina AU - Buster, Marcel AU - Stomp, Joris AU - Zweipfenning, Peter AU - Das, Kees AD - Public Health Service, Department of Epidemiology, Documentation and Health Promotion, Amsterdam, The Netherlands  , mceelen@ggd.amsterdam.nl Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1165 EP - 1173 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 30 IS - 9 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Urine KW - Forensic science KW - Drugs KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899155332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Post-mortem+toxicological+urine+screening+in+cause+of+death+determination&rft.au=Ceelen%2C+Manon%3BDorn%2C+Tina%3BBuster%2C+Marcel%3BStomp%2C+Joris%3BZweipfenning%2C+Peter%3BDas%2C+Kees&rft.aulast=Ceelen&rft.aufirst=Manon&rft.date=2011-09-01&rft.volume=30&rft.issue=9&rft.spage=1165&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327110390063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Urine; Forensic science; Drugs DO - http://dx.doi.org/10.1177/0960327110390063 ER - TY - JOUR T1 - Trends in U.S. Consumers' Safe Handling and Consumption of Food and Their Risk Perceptions, 1988 through 2010 AN - 899147248; 15712135 AB - Although survey results measuring the safety of consumers' food handling and risky food consumption practices have been published for over 20 years, evaluation of trends is impossible because the designs of published studies are not comparable. The Food Safety Surveys used comparable methods to interview U.S. adults by telephone in 1988, 1993, 2001, 2006, and 2010 about food handling (i.e., cross-contamination prevention) and risky consumption practices (eating raw or undercooked foods from animals) and perceived risk from foodborne illness. Sample sizes ranged from 1,620 to 4,547. Responses were analyzed descriptively, and four indices measuring meat, chicken, and egg cross-contamination, fish cross-contamination, risky consumption, and risk perceptions were analyzed using generalized linear models. The extent of media coverage of food safety issues was also examined. We found a substantial improvement in food handling and consumption practices and an increase in perceived risk from foodborne illness between 1993 and 1998. All indices were stable or declined between 1998 and 2006. Between 2006 and 2010, the two safe food handling practice indices increased significantly, but risk perceptions did not change, and safe consumption declined. Women had safer food handling and consumption practices than men. The oldest and youngest respondents and those with the highest education had the least safe food handling behaviors. Changes in safety of practices over the survey years are consistent with the change in the number of media stories about food safety in the periods between surveys. This finding suggests that increased media attention to food safety issues may raise awareness of food safety hazards and increase vigilance in food handling by consumers. JF - Journal of Food Protection AU - Fein, Sara B AU - Lando, Amy M AU - Levy, Alan S AU - Teisl, Mario F AU - Noblet, Caroline AD - School of Economics, University of Maine, 5782 Winslow Hall, Orono, Maine 04469, USA MS 11-017: Received 11 January 2011/Accepted 22 April 2011* Author for correspondence. Tel: 240-402-1824; Fax: 240 arrow right 02-2637; E-mail: sara.fein[AT]fda.hhs.gov. Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1513 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 United States VL - 74 IS - 9 SN - 0362-028X, 0362-028X KW - Risk Abstracts KW - USA KW - Education KW - Perception KW - meat KW - prevention KW - Fish KW - Food contamination KW - food-borne diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899147248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Trends+in+U.S.+Consumers%27+Safe+Handling+and+Consumption+of+Food+and+Their+Risk+Perceptions%2C+1988+through+2010&rft.au=Fein%2C+Sara+B%3BLando%2C+Amy+M%3BLevy%2C+Alan+S%3BTeisl%2C+Mario+F%3BNoblet%2C+Caroline&rft.aulast=Fein&rft.aufirst=Sara&rft.date=2011-09-01&rft.volume=74&rft.issue=9&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 37 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Education; Perception; meat; prevention; Fish; Food contamination; food-borne diseases; USA ER - TY - JOUR T1 - Molecular characterization of Salmonella enterica serovar Saintpaul isolated from imported seafood, pepper, environmental and clinical samples AN - 899146751; 15161060 AB - A total of 39 Salmonella enterica serovar Saintpaul strains from imported seafood, pepper and from environmental and clinical samples were analyzed for the presence of virulence genes, antibiotic resistance, plasmid and plasmid replicon types. Pulsed-field gel electrophoresis (PFGE) fingerprinting using the XbaI restriction enzyme and plasmid profiling were performed to assess genetic diversity. None of the isolates showed resistance to ampicillin, chloramphenicol, gentamicin, kanamycin, streptomycin, sulfisoxazole, and tetracycline. Seventeen virulence genes were screened for by PCR. All strains were positive for 14 genes (spiA, sifA, invA, spaN, sopE, sipB, iroN, msgA, pagC, orgA, prgH, lpfC, sitC, and tolC) and negative for three genes (spvB, pefA, and cdtB). Twelve strains, including six from clinical samples and six from seafood, carried one or more plasmids. Large plasmids, sized greater than 50 kb were detected in one clinical and three food isolates. One plasmid was able to be typed as IncI1 by PCR-based replicon typing. There were 25 distinct PFGE-XbaI patterns, clustered to two groups. Cluster A, with 68.5% similarity mainly consists of clinical isolates, while Cluster C, with 67.6% similarity, mainly consisted of shrimp isolates from India. Our findings indicated the genetic diversity of S. Saintpaul in clinical samples, imported seafood, and the environment and that this serotype possesses several virulent genes and plasmids which can cause salmonellosis. JF - Food Microbiology AU - Akiyama, Tatsuya AU - Khan, Ashraf A AU - Cheng, Chorng-Ming AU - Stefanova, Rossina AD - Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1124 EP - 1128 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 6 SN - 0740-0020, 0740-0020 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella enterica serovar Saintpaul KW - Pulsed-field gel electrophoresis KW - Plasmid KW - Seafood KW - Serotypes KW - Food KW - Anadromous species KW - Nucleotide sequence KW - Sulfisoxazole KW - Genetic diversity KW - Kanamycin KW - Streptomycin KW - Tetracyclines KW - India KW - Virulence KW - DNA fingerprinting KW - Polymerase chain reaction KW - Antibiotic resistance KW - Clinical isolates KW - Chloramphenicol KW - Decapoda KW - Enzymes KW - Ampicillin KW - Plasmids KW - Strains KW - Gentamicin KW - Typing KW - Salmonella enterica KW - Salmonellosis KW - DNA KW - Iron KW - J 02310:Genetics & Taxonomy KW - Q1 08625:Non-edible products KW - O 1050:Vertebrates, Urochordates and Cephalochordates KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899146751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Molecular+characterization+of+Salmonella+enterica+serovar+Saintpaul+isolated+from+imported+seafood%2C+pepper%2C+environmental+and+clinical+samples&rft.au=Akiyama%2C+Tatsuya%3BKhan%2C+Ashraf+A%3BCheng%2C+Chorng-Ming%3BStefanova%2C+Rossina&rft.aulast=Akiyama&rft.aufirst=Tatsuya&rft.date=2011-09-01&rft.volume=28&rft.issue=6&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Virulence; Nucleotide sequence; Anadromous species; DNA; Polymerase chain reaction; Genetic diversity; Seafood; Strains; Plasmids; Clinical isolates; Chloramphenicol; Serotypes; Food; Sulfisoxazole; Ampicillin; Enzymes; Kanamycin; Streptomycin; Tetracyclines; Gentamicin; DNA fingerprinting; Typing; Salmonellosis; Pulsed-field gel electrophoresis; Iron; Antibiotic resistance; Decapoda; Salmonella enterica; India DO - http://dx.doi.org/10.1016/j.fm.2011.03.003 ER - TY - JOUR T1 - The determinacy of reproducibility assessments of qualitative microbial food borne pathogen methods detecting a few microbes per analytical portion AN - 899146745; 15161059 AB - A summary of an examination of studies of interlaboratory reproducibility of measurements for detecting the presence of microorganisms in food products is presented. In such studies multiple laboratories, 10 or more, compare the performances of reference and test methods at the limit of detection of the methods that is at spiking levels around 1 cfu per analytical portion. A laboratory's performance is expressed as the number of positive replicates detected per set of six. The data only imply the presence or absence of significant between-laboratory effects with the test method relative to the reference method. It is difficult to parse the observed variability into the contributions of the sample variability and between-laboratory effects. This is because at spiking levels close to 1 cfu per portion it cannot be assured that laboratories are examining portions with equivalent numbers of the target microbe. In this study published data are reformulated to the number of laboratories observing a given number of positive results per replicate set in order to reflect the inhomogeneity of the spike distribution in the replicate portions. A mean spiking level that is less uncertain than the reported 3-tube reference method MPN value is estimated from the pooled proportions of positives that the laboratories obtained with the reference method. The expected distribution of the spike was calculated from its mean value using the binomial equation. The numerical distributions of the laboratories among the 7 possible positive categories (0-6 positives per replicate set) were statistically indistinguishable from the expected binomial distribution thus corroborating this approach. Probable instances of interlaboratory performance differences were detected by further statistical analysis. This analytical approach, as well as transparently reflecting the sampling variability, also suggested ways of improving and simplifying such studies. JF - Food Microbiology AU - Hitchins, AD AD - FDA, College Park, MD 20740-3835, USA, anthony.hitchins@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1140 EP - 1144 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 6 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Pathogens KW - Qualitative detection methods KW - Reproducibility KW - Mathematical models KW - Colony-forming cells KW - Statistical analysis KW - Microorganisms KW - Sampling KW - Food quality KW - Firing pattern KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899146745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=The+determinacy+of+reproducibility+assessments+of+qualitative+microbial+food+borne+pathogen+methods+detecting+a+few+microbes+per+analytical+portion&rft.au=Hitchins%2C+AD&rft.aulast=Hitchins&rft.aufirst=AD&rft.date=2011-09-01&rft.volume=28&rft.issue=6&rft.spage=1140&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mathematical models; Colony-forming cells; Microorganisms; Statistical analysis; Sampling; Pathogens; Food quality; Firing pattern DO - http://dx.doi.org/10.1016/j.fm.2011.03.005 ER - TY - JOUR T1 - Lysozyme as a barrier to growth of Bacillus anthracis strain Sterne in liquid egg white, milk and beef AN - 899143933; 15161049 AB - In this study, we investigated the role of lysozyme on the viability of Bacillus cereus, Bacillus subtilis, Bacillus pumilus and Bacillus anthracis (Sterne) in egg white (EW), ground beef and milk. At 35 degree C in EW, growth rates (GR) for B. cereus, B. subtilis, B. pumilus and B. anthracis were 0.005, -0.018, a closed integral #146; 0.028 and -0.029 OD600/h, respectively. Heat-treating EW at 55 and 60 degree C reduced the inactivating effect of EW by 3.1 and 10.5-fold, respectively. Addition of lysozyme (2 mg/ml) to 60 degree C-treated EW increased the inactivation rate 5.76-fold, indicating involvement of lysozyme in B. anthracis inactivation. B. anthracis inactivation was influenced by pH, as shown by a progressive increase in inactivation rate from 0.25 to -4.42 logs CFU /h over a pH range of 6.0-8.5. Adding 2 mg/ml lysozyme to milk and ground beef also suppressed the growth of B. anthracis 3.3 and 6.5-fold, respectively. These data indicate that lysozyme, as a natural component of EW or potential additive in other foods, could reduce biothreat risks presented by bioterror agents. JF - Food Microbiology AU - Sung, Kidon AU - Khan, Saeed A AU - Nawaz, Mohamed S AU - Cerniglia, Carl E AU - Tamplin, Mark L AU - Phillips, Robert W AU - Kelley, Lynda Collins AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1231 EP - 1234 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 6 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacillus anthracis KW - Lysozyme KW - Spore KW - Egg white KW - Inactivation KW - Growth rate KW - Bacillus subtilis KW - Milk KW - Data processing KW - Bacillus cereus KW - Albumen KW - Food additives KW - Beef KW - Colony-forming cells KW - pH effects KW - Bacillus pumilus KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899143933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Lysozyme+as+a+barrier+to+growth+of+Bacillus+anthracis+strain+Sterne+in+liquid+egg+white%2C+milk+and+beef&rft.au=Sung%2C+Kidon%3BKhan%2C+Saeed+A%3BNawaz%2C+Mohamed+S%3BCerniglia%2C+Carl+E%3BTamplin%2C+Mark+L%3BPhillips%2C+Robert+W%3BKelley%2C+Lynda+Collins&rft.aulast=Sung&rft.aufirst=Kidon&rft.date=2011-09-01&rft.volume=28&rft.issue=6&rft.spage=1231&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Growth rate; Lysozyme; Food additives; Albumen; Data processing; Milk; Beef; Colony-forming cells; pH effects; Bacillus subtilis; Bacillus cereus; Bacillus anthracis; Bacillus pumilus DO - http://dx.doi.org/10.1016/j.fm.2011.03.002 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF GINSENG (CAS NO. 50647-08-0) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 893887641; 21921964 AB - Ginseng root is widely used as an herbal remedy and dietary supplement. We studied the effects of ginseng root extract on rats and mice to identify potential toxic or cancer-related hazards. We administered solutions containing extracts of ginseng root in methylcellulose through a tube directly into the stomach of male and female rats and mice five times a week for two years. Groups of 50 animals received 1,250, 2,500, or 5,000 milligrams of ginseng root extract per kilogram of body weight. Similar groups of animals were given solutions of methylcellulose with no chemical added and served as the control groups. At the end of the study tissues from more than 40 sites were examined for every animal. Except for the female rats receiving 5,000 mg/kg of ginseng, survival and body weights of all exposed groups of animals were similar to their controls. There were no increases in the incidences of cancers at any sites, and the rates of mammary gland cancers in female rats were lower in animals given ginseng extract than in animals in their control group. We conclude that ginseng did not cause cancer in male or female rats or mice. The incidence of mammary gland tumors in female rats was lower than the background rate in animals receiving ginseng. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1 EP - 149 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Studies KW - Rodents KW - Toxicology KW - Carcinogens KW - Herbal medicine KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mice KW - Male KW - Female KW - Toxicity Tests KW - Carcinogenicity Tests KW - Panax UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893887641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GINSENG+%28CAS+NO.+50647-08-0%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-09-01&rft.volume=&rft.issue=567&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2011 N1 - Document feature - Illustrations; Tables; Diagrams; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 893887638 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893887638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-09-01&rft.volume=&rft.issue=567&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 893887631 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893887631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-09-01&rft.volume=&rft.issue=567&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2011 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Estimating water supply arsenic levels in the New England Bladder Cancer Study. AN - 887501970; 21421449 AB - Ingestion of inorganic arsenic in drinking water is recognized as a cause of bladder cancer when levels are relatively high (≥ 150 µg/L). The epidemiologic evidence is less clear at the low-to-moderate concentrations typically observed in the United States. Accurate retrospective exposure assessment over a long time period is a major challenge in conducting epidemiologic studies of environmental factors and diseases with long latency, such as cancer. We estimated arsenic concentrations in the water supplies of 2,611 participants in a population-based case-control study in northern New England. Estimates covered the lifetimes of most study participants and were based on a combination of arsenic measurements at the homes of the participants and statistical modeling of arsenic concentrations in the water supply of both past and current homes. We assigned a residential water supply arsenic concentration for 165,138 (95%) of the total 173,361 lifetime exposure years (EYs) and a workplace water supply arsenic level for 85,195 EYs (86% of reported occupational years). Three methods accounted for 93% of the residential estimates of arsenic concentration: direct measurement of water samples (27%; median, 0.3 µg/L; range, 0.1-11.5), statistical models of water utility measurement data (49%; median, 0.4 µg/L; range, 0.3-3.3), and statistical models of arsenic concentrations in wells using aquifers in New England (17%; median, 1.6 µg/L; range, 0.6-22.4). We used a different validation procedure for each of the three methods, and found our estimated levels to be comparable with available measured concentrations. This methodology allowed us to calculate potential drinking water exposure over long periods. JF - Environmental health perspectives AU - Nuckols, John R AU - Freeman, Laura E Beane AU - Lubin, Jay H AU - Airola, Matthew S AU - Baris, Dalsu AU - Ayotte, Joseph D AU - Taylor, Anne AU - Paulu, Chris AU - Karagas, Margaret R AU - Colt, Joanne AU - Ward, Mary H AU - Huang, An-Tsun AU - Bress, William AU - Cherala, Sai AU - Silverman, Debra T AU - Cantor, Kenneth P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. jnuckols@colostate.edu Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1279 EP - 1285 VL - 119 IS - 9 KW - Drinking Water KW - 0 KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Maine -- epidemiology KW - Young Adult KW - Regression Analysis KW - New Hampshire -- epidemiology KW - Humans KW - Vermont -- epidemiology KW - Retrospective Studies KW - Infant, Newborn KW - Aged KW - Child KW - Risk Assessment KW - Infant KW - Adult KW - Case-Control Studies KW - Environmental Exposure KW - Middle Aged KW - Epidemiological Monitoring KW - Adolescent KW - Male KW - Female KW - Arsenic -- analysis KW - Water Pollutants, Chemical -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Drinking Water -- chemistry KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887501970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+water+supply+arsenic+levels+in+the+New+England+Bladder+Cancer+Study.&rft.au=Nuckols%2C+John+R%3BFreeman%2C+Laura+E+Beane%3BLubin%2C+Jay+H%3BAirola%2C+Matthew+S%3BBaris%2C+Dalsu%3BAyotte%2C+Joseph+D%3BTaylor%2C+Anne%3BPaulu%2C+Chris%3BKaragas%2C+Margaret+R%3BColt%2C+Joanne%3BWard%2C+Mary+H%3BHuang%2C+An-Tsun%3BBress%2C+William%3BCherala%2C+Sai%3BSilverman%2C+Debra+T%3BCantor%2C+Kenneth+P&rft.aulast=Nuckols&rft.aufirst=John&rft.date=2011-09-01&rft.volume=119&rft.issue=9&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002345 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-13 N1 - Date created - 2011-09-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Int J Occup Med Environ Health. 2001;14(2):171-5 [11548067] Am J Epidemiol. 2004 Feb 15;159(4):381-9 [14769642] Environ Health Perspect. 2004 Jun;112(9):1007-15 [15198921] Cancer Causes Control. 2004 Jun;15(5):465-72 [15286466] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Environ Health Perspect. 1998 Aug;106 Suppl 4:1047-50 [9703491] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Environ Sci Technol. 2006 Jun 1;40(11):3578-85 [16786697] Int Arch Occup Environ Health. 2007 Jan;80(3):184-97 [16897097] J Natl Cancer Inst. 2007 Jun 20;99(12):920-8 [17565158] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):252-7 [17382983] Environ Health Perspect. 2008 Feb;116(2):231-7 [18288323] Occup Environ Med. 2008 Jun;65(6):420-9 [18032532] Regul Toxicol Pharmacol. 2008 Dec;52(3):299-310 [18783726] Lancet Oncol. 2009 May;10(5):453-4 [19418618] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] J Expo Sci Environ Epidemiol. 2010 May;20(3):245-54 [19401722] Am J Epidemiol. 2003 Dec 15;158(12):1193-201 [14652304] Erratum In: Environ Health Perspect. 2011 Dec;119(12):A509 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002345 ER - TY - JOUR T1 - Methyleugenol genotoxicity in the Fischer 344 rat using the comet assay and pathway-focused gene expression profiling. AN - 886917419; 21659616 AB - Methyleugenol (MEG), a constituent of human food, induces malignant tumors in multiple tissues of rats and mice. Although MEG forms DNA adducts and induces unscheduled DNA synthesis in rat liver, it is negative in many in vitro genetic toxicity assays. In the present study, we evaluated MEG-induced DNA damage in the rat using (1) the alkaline Comet assay, (2) the oxidative Comet assay, and (3) expression profiling of genes associated with DNA damage pathways. Male F344 rats received single oral doses of 400 or 1000 mg/kg body weight (bw) MEG and DNA damage was assessed by the Comet assay in liver, bladder, bone marrow, kidney, and lung 3 h and 24 h later. MEG failed to produce any increase in DNA damage. In addition, rats were given a single oral dose of 2000 mg/kg bw MEG, and Comet assays were performed with liver, bone marrow, and bladder 1, 3, 6, and 8 h later. With one exception (bone marrow at 8 h), no DNA damage was detected. Enzyme-modified Comet assays were conducted in parallel with standard Comet assays in liver. Whereas no MEG-induced DNA damage was detected following formamidopyrimidine DNA glycosylase digestion, digestion with endonuclease III resulted in increases in DNA damage at the 6- and 8-h sampling times. Gene expression analysis on the livers from MEG-exposed rats showed significant reduction in genes associated with DNA repair. The results indicate that MEG induces DNA damage in rat liver and that oxidative DNA damages may be partly responsible for the genotoxicity of MEG in rodents. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ding, Wei AU - Levy, Dan D AU - Bishop, Michelle E AU - Lyn-Cook Lascelles, E AU - Kulkarni, Rohan AU - Chang, Ching-We AU - Aidoo, Anane AU - Manjanatha, Mugimane G AD - U.S. Food and Drug Administration, Jefferson Laboratories, National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, Arkansas 72079, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 103 EP - 112 VL - 123 IS - 1 KW - Mutagens KW - 0 KW - methyleugenol KW - 29T9VA6R7M KW - Eugenol KW - 3T8H1794QW KW - DNA KW - 9007-49-2 KW - Deoxyribonucleases, Type III Site-Specific KW - EC 3.1.21.5 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - DNA Repair -- genetics KW - Bone Marrow Cells -- drug effects KW - Gene Expression Profiling KW - Animals KW - Rats, Inbred F344 KW - Liver -- drug effects KW - Deoxyribonucleases, Type III Site-Specific -- metabolism KW - Male KW - Deoxyribonucleases, Type III Site-Specific -- genetics KW - DNA Repair -- drug effects KW - Urinary Bladder -- drug effects KW - Comet Assay KW - Eugenol -- toxicity KW - Mutagens -- classification KW - DNA Damage KW - Eugenol -- classification KW - Eugenol -- analogs & derivatives KW - Mutagens -- toxicity KW - Gene Expression Regulation -- drug effects KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Methyleugenol+genotoxicity+in+the+Fischer+344+rat+using+the+comet+assay+and+pathway-focused+gene+expression+profiling.&rft.au=Ding%2C+Wei%3BLevy%2C+Dan+D%3BBishop%2C+Michelle+E%3BLyn-Cook+Lascelles%2C+E%3BKulkarni%2C+Rohan%3BChang%2C+Ching-We%3BAidoo%2C+Anane%3BManjanatha%2C+Mugimane+G&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2011-09-01&rft.volume=123&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr153 ER - TY - JOUR T1 - Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands. AN - 886917413; 21625005 AB - Clinical gene transfer holds promise for the treatment of many inherited and acquired disorders. A key consideration for all clinical gene transfer applications is the tight control of transgene expression. We have examined the safety and biodistribution of a serotype 2, recombinant adeno-associated viral (AAV2) vector that encodes a rapamycin-responsive chimeric transcription factor, which regulates the expression of a therapeutic transgene (human erythropoietin [hEpo]). The vector, AAV2-TF2.3w-hEpo (2.5 × 10(7)-2.5 × 10(10) particles), was administered once to a single submandibular gland of male and female mice and mediated hEpo expression in vivo following a rapamycin injection but not in its absence. Control (saline treated) and vector-treated animals maintained their weight, and consumed food and water, similarly. Vector delivery led to no significant toxicological effects as judged by hematology, clinical chemistry, and gross and microscopic pathology evaluations. On day 3 after vector delivery, vector copies were not only abundant in the targeted right submandibular gland but also detected in multiple other tissues. Vector was cleared from the targeted gland much more rapidly in female mice than in male mice. Overall, our results are consistent with the notion that administration of the AAV2-TF2.3w-hEpo vector to salivary glands posed no significant risk in mice. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Zheng, Changyu AU - Voutetakis, Antonis AU - Goldstein, Benjamin AU - Afione, Sandra AU - Rivera, Victor M AU - Clackson, Tim AU - Wenk, Martin L AU - Boyle, Molly AU - Nyska, Abraham AU - Chiorini, John A AU - Vallant, Molly AU - Irwin, Richard D AU - Baum, Bruce J AD - Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, 20892, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 247 EP - 255 VL - 123 IS - 1 KW - Erythropoietin KW - 11096-26-7 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Body Weight KW - Animals KW - Erythropoietin -- blood KW - Sex Factors KW - Sirolimus -- pharmacology KW - Toxicity Tests KW - Erythropoietin -- genetics KW - Mice KW - Mice, Inbred BALB C KW - Male KW - Female KW - Risk Assessment KW - Genetic Vectors -- administration & dosage KW - Submandibular Gland -- virology KW - Submandibular Gland -- metabolism KW - Gene Transfer Techniques -- adverse effects KW - Dependovirus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/886917413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Assessment+of+the+safety+and+biodistribution+of+a+regulated+AAV2+gene+transfer+vector+after+delivery+to+murine+submandibular+glands.&rft.au=Zheng%2C+Changyu%3BVoutetakis%2C+Antonis%3BGoldstein%2C+Benjamin%3BAfione%2C+Sandra%3BRivera%2C+Victor+M%3BClackson%2C+Tim%3BWenk%2C+Martin+L%3BBoyle%2C+Molly%3BNyska%2C+Abraham%3BChiorini%2C+John+A%3BVallant%2C+Molly%3BIrwin%2C+Richard+D%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2011-09-01&rft.volume=123&rft.issue=1&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr144 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Gene Ther. 1999 Nov 20;10(17):2789-97 [10584925] Methods Mol Biol. 2010;666:3-20 [20717774] Nat Genet. 2000 Mar;24(3):257-61 [10700178] J Virol. 2000 Oct;74(20):9451-63 [11000214] Int Rev Cytol. 2002;213:93-146 [11837896] Blood. 2002 Apr 15;99(8):2670-6 [11929752] J Clin Invest. 2002 Aug;110(4):499-504 [12189244] J Clin Microbiol. 2003 Nov;41(11):5046-52 [14605137] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3053-8 [14978265] Gene Ther. 2004 Apr;11(8):729-33 [14737095] Gene Ther. 2004 Oct;11(19):1425-6 [15269715] Nature. 1991 Jan 24;349(6307):351-2 [1987492] Am J Physiol. 1994 Jun;266(6 Pt 1):G1146-55 [8023944] Nat Med. 1996 Sep;2(9):1028-32 [8782462] Hum Gene Ther. 1996 Nov 10;7(17):2101-12 [8934224] Hum Gene Ther. 1996 Nov 10;7(17):2177-84 [8934231] Hum Gene Ther. 1998 Dec 10;9(18):2745-60 [9874273] Am J Physiol. 1999 Feb;276(2 Pt 1):E223-32 [9950780] J Virol. 1999 Mar;73(3):1949-55 [9971774] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8657-62 [10411931] Trends Mol Med. 2004 Dec;10(12):585-90 [15567328] Blood. 2005 Feb 15;105(4):1424-30 [15507527] J Gene Med. 2005 Apr;7(4):432-41 [15515118] J Endocrinol. 2005 Jun;185(3):363-72 [15930162] Gene Ther. 2006 Jan;13(2):187-90 [16177817] Nat Med. 2006 Mar;12(3):342-7 [16474400] Gene Ther. 2006 Apr;13(7):594-601 [16341060] Hum Gene Ther. 2007 Feb;18(2):142-50 [17328682] Hum Gene Ther. 2007 Nov;18(11):1109-18 [17939749] Mol Ther. 2008 Jun;16(6):1089-97 [18388914] J Gene Med. 2009 Jun;11(6):506-14 [19326368] Hum Gene Ther. 2008 Dec;19(12):1401-5 [18764738] J Gene Med. 2010 Jan;12(1):3-10 [19941317] Mol Ther. 2010 Jan;18(1):80-6 [19904234] Gene Ther. 2010 Jan;17(1):50-60 [19759566] Oral Oncol. 2010 Jan;46(1):4-8 [19892587] J Virol. 2000 Mar;74(5):2420-5 [10666273] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr144 ER - TY - JOUR T1 - Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction. AN - 885563377; 21642617 AB - Aristolochic acid (AA) is a strong cytotoxic nephrotoxin and carcinogen associated with the development of urothelial cancer in humans. AA induces forestomach, kidney and urothelial tract tumours in rats and mice. This study was conducted to characterise AA's carcinogenic mechanism of action and compare allele-specific competitive blocker-polymerase chain reaction (ACB-PCR)-based early detection of carcinogenic effect using two different tumour-relevant endpoints. H-Ras codon 61 CAA→CTA mutation was analysed because it is found in rodent forestomach tumours and A:T→T:A transversion is the predominant mutational specificity induced by AA. K-Ras codon 12 GGT→GAT mutation was analysed because it is a common spontaneous mutation present in various rodent tissues and may be a useful generic biomarker for carcinogenic effect. DNA samples from Big Blue rats treated with 0, 0.1, 1.0 or 10.0 mg AA/kg body weight (bw) by gavage, 5 days/week for 12 weeks were used in ACB-PCR in order to examine the induction of the two specific mutations. A significant dose-dependent induction of H-Ras mutant fraction (MF) was observed in liver and kidney. Statistically significant correlations were observed between AA-induced DNA adduct levels or cII mutant frequencies (previously measured in the same rats) and H-Ras MF measurements. No correlation between AA dose and K-Ras MF was found in liver or kidney, although there was a significant induction of K-Ras mutation in kidneys exposed to 0.1 mg/kg bw AA relative to controls. Thus, the data establish a straightforward dose-related increase in H-Ras MF due to fixation of AA-induced DNA adducts, whereas the common spontaneous K-Ras mutation showed a non-monotonic dose-response, consistent with loss of non-targeted mutation at cytotoxic doses. JF - Mutagenesis AU - Wang, Yiying AU - Meng, Fanxue AU - Arlt, Volker M AU - Mei, Nan AU - Chen, Tao AU - Parsons, Barbara L AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-120, 3900 NCTR Road, Jefferson, AR 72079, USA. yiying.wang@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 619 EP - 628 VL - 26 IS - 5 KW - Aristolochic Acids KW - 0 KW - Codon KW - DNA Adducts KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - Alleles KW - Rats, Transgenic KW - Male KW - Genes, ras KW - Aristolochic Acids -- toxicity KW - Cell Transformation, Neoplastic -- chemically induced KW - Mutation -- genetics KW - Aristolochic Acids -- pharmacology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Aristolochic+acid-induced+carcinogenesis+examined+by+ACB-PCR+quantification+of+H-Ras+and+K-Ras+mutant+fraction.&rft.au=Wang%2C+Yiying%3BMeng%2C+Fanxue%3BArlt%2C+Volker+M%3BMei%2C+Nan%3BChen%2C+Tao%3BParsons%2C+Barbara+L&rft.aulast=Wang&rft.aufirst=Yiying&rft.date=2011-09-01&rft.volume=26&rft.issue=5&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-20 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger023 ER - TY - JOUR T1 - Photoirradiation of polycyclic aromatic hydrocarbon diones by UVA light leading to lipid peroxidation. AN - 885559770; 21680011 AB - Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous genotoxic environmental pollutants and potentially pose a health risk to humans. In most if not all cases, PAHs in the environment can be oxidized into their corresponding PAH-diones. This process is considered a detoxification pathway with regard to tumorigenicity. Nevertheless, photo-induced toxicological activity of PAH-diones has not been systematically investigated. In this study, we show that 27 potential environmental PAH-diones induced lipid peroxidation, in a dose (light) response manner, when irradiated with UVA at 7 and 21 J cm(-2). Photoirradiation in the presence of sodium azide, deuterated methanol, or superoxide dismutase revealed that lipid peroxidation is mediated by reactive oxygen species. Electron spin resonance (ESR) spin trapping studies supported this observation. These results suggest that UVA photoirradiation of PAH-diones generates reactive oxygen species and induces lipid peroxidation. Published by Elsevier Ltd. JF - Chemosphere AU - Zhao, Yuewei AU - Xia, Qingsu AU - Yin, Jun-Jie AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. yuewei.zhao@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 83 EP - 91 VL - 85 IS - 1 KW - Free Radicals KW - 0 KW - Linoleic Acids KW - Mutagens KW - Polycyclic Aromatic Hydrocarbons KW - Superoxides KW - 11062-77-4 KW - Singlet Oxygen KW - 17778-80-2 KW - methyl linoleate KW - 24N6726DE5 KW - Index Medicus KW - Superoxides -- chemistry KW - Ultraviolet Rays KW - Photochemical Processes KW - Free Radicals -- chemistry KW - Singlet Oxygen -- chemistry KW - Linoleic Acids -- chemistry KW - Polycyclic Aromatic Hydrocarbons -- toxicity KW - Lipid Peroxidation -- radiation effects KW - Mutagens -- toxicity KW - Polycyclic Aromatic Hydrocarbons -- chemistry KW - Mutagens -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885559770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Photoirradiation+of+polycyclic+aromatic+hydrocarbon+diones+by+UVA+light+leading+to+lipid+peroxidation.&rft.au=Zhao%2C+Yuewei%3BXia%2C+Qingsu%3BYin%2C+Jun-Jie%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Zhao&rft.aufirst=Yuewei&rft.date=2011-09-01&rft.volume=85&rft.issue=1&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2011.05.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-16 N1 - Date created - 2011-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.chemosphere.2011.05.040 ER - TY - JOUR T1 - Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant. AN - 885558871; 21724893 AB - Antimicrobial residues found in municipal wastewater may increase selective pressure on microorganisms for development of resistance, but studies with mixed microbial cultures derived from wastewater have suggested that some bacteria are able to inactivate fluoroquinolones. Medium containing N-phenylpiperazine and inoculated with wastewater was used to enrich fluoroquinolone-modifying bacteria. One bacterial strain isolated from an enrichment culture was identified by 16S rRNA gene sequence analysis as a Microbacterium sp. similar to a plant growth-promoting bacterium, Microbacterium azadirachtae (99.70%), and a nematode pathogen, "M. nematophilum" (99.02%). During growth in medium with norfloxacin, this strain produced four metabolites, which were identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and nuclear magnetic resonance (NMR) analyses as 8-hydroxynorfloxacin, 6-defluoro-6-hydroxynorfloxacin, desethylene norfloxacin, and N-acetylnorfloxacin. The production of the first three metabolites was enhanced by ascorbic acid and nitrate, but it was inhibited by phosphate, amino acids, mannitol, formate, and thiourea. In contrast, N-acetylnorfloxacin was most abundant in cultures supplemented with amino acids. This is the first report of defluorination and hydroxylation of a fluoroquinolone by an isolated bacterial strain. The results suggest that some bacteria may degrade fluoroquinolones in wastewater to metabolites with less antibacterial activity that could be subject to further degradation by other microorganisms. JF - Applied and environmental microbiology AU - Kim, Dae-Wi AU - Heinze, Thomas M AU - Kim, Bong-Soo AU - Schnackenberg, Laura K AU - Woodling, Kellie A AU - Sutherland, John B AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 6100 EP - 6108 VL - 77 IS - 17 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - DNA, Ribosomal KW - RNA, Ribosomal, 16S KW - Norfloxacin KW - N0F8P22L1P KW - Index Medicus KW - Phylogeny KW - RNA, Ribosomal, 16S -- genetics KW - DNA, Bacterial -- chemistry KW - Biotransformation KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - DNA, Ribosomal -- chemistry KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Sequence Analysis, DNA KW - DNA, Ribosomal -- genetics KW - Cluster Analysis KW - Magnetic Resonance Spectroscopy KW - Anti-Bacterial Agents -- metabolism KW - Actinomycetales -- isolation & purification KW - Actinomycetales -- genetics KW - Norfloxacin -- metabolism KW - Water Microbiology KW - Actinomycetales -- metabolism KW - Actinomycetales -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885558871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Modification+of+norfloxacin+by+a+Microbacterium+sp.+strain+isolated+from+a+wastewater+treatment+plant.&rft.au=Kim%2C+Dae-Wi%3BHeinze%2C+Thomas+M%3BKim%2C+Bong-Soo%3BSchnackenberg%2C+Laura+K%3BWoodling%2C+Kellie+A%3BSutherland%2C+John+B&rft.aulast=Kim&rft.aufirst=Dae-Wi&rft.date=2011-09-01&rft.volume=77&rft.issue=17&rft.spage=6100&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00545-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-13 N1 - Date created - 2011-08-25 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - HQ833039; GENBANK N1 - SuppNotes - Cited By: Int J Syst Bacteriol. 1999 Oct;49 Pt 4:1353-7 [10555312] J Agric Food Chem. 2010 Sep 22;58(18):10169-75 [20726585] Appl Environ Microbiol. 2000 Jun;66(6):2664-7 [10831454] J Comput Biol. 2000 Feb-Apr;7(1-2):203-14 [10890397] Curr Biol. 2000 Dec 14-28;10(24):1615-8 [11137017] J Antimicrob Chemother. 2001 Mar;47(3):271-5 [11222559] Int J Syst Evol Microbiol. 2001 Jul;51(Pt 4):1267-76 [11491322] Anal Chem. 2001 Aug 1;73(15):3632-8 [11510827] Appl Microbiol Biotechnol. 2001 Aug;56(3-4):474-7 [11549022] Biosci Biotechnol Biochem. 2002 May;66(5):1022-31 [12092811] Free Radic Biol Med. 2002 Sep 15;33(6):818-26 [12208369] Biochem Biophys Res Commun. 2002 Oct 4;297(4):1003-7 [12359254] Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):3-13 [12448700] Environ Sci Technol. 2003 Mar 1;37(5):899-907 [12666919] J Antimicrob Chemother. 2003 May;51 Suppl 1:1-11 [12702698] Biochem J. 1977 Jun 1;163(3):441-8 [195574] Mol Biol Evol. 1987 Jul;4(4):406-25 [3447015] FEMS Microbiol Lett. 1989 Feb;57(3):279-82 [2498156] Am J Vet Res. 1992 Nov;53(11):2084-9 [1466505] J Vet Pharmacol Ther. 1995 Jun;18(3):220-5 [7674459] Eur J Biochem. 1996 Aug 15;240(1):232-8 [8797858] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Appl Environ Microbiol. 1997 Nov;63(11):4272-81 [9361414] J Ind Microbiol Biotechnol. 1997 Nov-Dec;19(5-6):378-84 [9451835] Antimicrob Agents Chemother. 1998 May;42(5):1151-9 [9593143] Int J Syst Bacteriol. 1998 Jul;48 Pt 3:739-47 [9734028] Appl Environ Microbiol. 1999 Apr;65(4):1556-63 [10103250] Microbiology. 1999 Jul;145 ( Pt 7):1797-807 [10439419] Bioinformatics. 2005 Jul 15;21(14):3171-3 [15855247] Nat Med. 2006 Jan;12(1):83-8 [16369542] Appl Microbiol Biotechnol. 2006 Jun;71(1):90-100 [16328445] Appl Environ Microbiol. 2006 Sep;72(9):5790-3 [16957195] J Chromatogr A. 2007 Jan 12;1139(1):45-52 [17157863] Appl Microbiol Biotechnol. 2007 Mar;74(3):676-82 [17089119] Water Res. 2007 Oct;41(18):4164-76 [17524445] Int J Syst Evol Microbiol. 2007 Oct;57(Pt 10):2259-61 [17911292] Water Res. 2007 Nov;41(19):4526-34 [17631935] J Toxicol Environ Health B Crit Rev. 2007 Dec;10(8):559-73 [18049923] Chemosphere. 2008 Jun;72(6):968-73 [18485444] J Clin Microbiol. 2008 Nov;46(11):3646-52 [18799696] J Hazard Mater. 2009 Mar 15;162(2-3):1204-10 [18621476] J Appl Microbiol. 2009 Feb;106(2):564-71 [19200322] Bioresour Technol. 2009 May;100(10):2732-6 [19195880] J Phys Chem A. 2009 Jul 9;113(27):7846-51 [19507813] J Chromatogr A. 2009 Nov 20;1216(47):8312-8 [19825501] J Hazard Mater. 2010 Jan 15;173(1-3):151-8 [19733436] Environ Pollut. 2010 May;158(5):1444-50 [20096493] Int J Syst Evol Microbiol. 2010 Jul;60(Pt 7):1687-92 [19734284] J Biochem. 2000 May;127(5):731-7 [10788780] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.00545-11 ER - TY - JOUR T1 - Identification of Mycoplasmas Using a Fluorophore-Free Microarray and Infrared Chemical Imaging (IRCI) AN - 883045780; 15380202 AB - A novel application of mid-infrared chemical imaging (IRCI) for the fluorophore-free detection and identification of mycoplasma species is reported for the first time. The PCR-amplified biotinylated targets hybridized to microarray probes were treated with streptavidin-gold nanoparticles followed by silver enhancement. This modification has the potential to expand the implementation of DNA microarray techniques in laboratories involved in the detection of cell substrates, other biological products, and clinical materials for the presence of mycoplasmas. JF - Journal of Microbiological Methods AU - Mossoba, M M AU - Chizhikov, V AU - Volokhov, D V AU - Martinez-Diaz Milians, K AU - Schoen, B AU - Al-Khaldi, S F Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 383 EP - 386 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 86 IS - 3 SN - 0167-7012, 0167-7012 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Probes KW - imaging KW - DNA microarrays KW - Silver KW - nanoparticles KW - Mycoplasma KW - W 30900:Methods KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883045780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=Identification+of+Mycoplasmas+Using+a+Fluorophore-Free+Microarray+and+Infrared+Chemical+Imaging+%28IRCI%29&rft.au=Mossoba%2C+M+M%3BChizhikov%2C+V%3BVolokhov%2C+D+V%3BMartinez-Diaz+Milians%2C+K%3BSchoen%2C+B%3BAl-Khaldi%2C+S+F&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2011-09-01&rft.volume=86&rft.issue=3&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2011.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Probes; nanoparticles; Silver; DNA microarrays; imaging; Mycoplasma DO - http://dx.doi.org/10.1016/j.mimet.2011.06.003 ER - TY - JOUR T1 - Toxicity and carcinogenicity of androstenedione in F344/N rats and B6C3F1 mice. AN - 880716943; 21651954 AB - Androstenedione was marketed as a dietary supplement to increase muscle mass during training. Due to concern over long-term use, the NTP evaluated the subchronic and chronic toxicity and carcinogenicity of androstenedione in male and female F344/N rats and B6C3F1 mice. In subchronic studies, dose limiting effects were not observed. A chronic (2-year) exposure by gavage at 10, 20, or 50 mg/kg in rats and male mice, and 2, 10, or 50 mg/kg in female mice (50 mg/kg, maximum feasible dose) was conducted. Increased incidences of lung alveolar/bronchiolar adenoma and carcinoma occurred in the 20 mg/kg male rats and increases in mononuclear cell leukemia occurred in the 20 and 50 mg/kg female rats, which may have been related to androstenedione administration. In male and female mice, androstenedione was carcinogenic based upon a significant increase in hepatocellular tumors. A marginal increase in pancreatic islet cell adenomas in male (50 mg/kg) and female (2, 10, 50 mg/kg) mice was considered to be related to androstenedione administration. Interestingly, incidences of male rat Leydig cell adenomas and female rat mammary gland fibroadenomas decreased. In conclusion, androstenedione was determined to be carcinogenic in male and female mice, and may have been carcinogenic in rats. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Blystone, Chad R AU - Elmore, Susan A AU - Witt, Kristine L AU - Malarkey, David E AU - Foster, Paul M D AD - National Toxicology Program, National Institutes of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States. blystonecr@niehs.nih.gov Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 2116 EP - 2124 VL - 49 IS - 9 KW - Carcinogens KW - 0 KW - Androstenedione KW - 409J2J96VR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Androstenedione -- toxicity KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880716943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Toxicity+and+carcinogenicity+of+androstenedione+in+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Blystone%2C+Chad+R%3BElmore%2C+Susan+A%3BWitt%2C+Kristine+L%3BMalarkey%2C+David+E%3BFoster%2C+Paul+M+D&rft.aulast=Blystone&rft.aufirst=Chad&rft.date=2011-09-01&rft.volume=49&rft.issue=9&rft.spage=2116&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Transplantation. 1980 Aug;30(2):90-6 [7010713] Cancer. 1980 Sep 15;46(6):1401-4 [6251960] Carcinogenesis. 1983 Sep;4(9):1179-83 [6349845] Endocrinology. 1984 Jun;114(6):2100-6 [6539197] Biol Reprod. 1984 Sep;31(2):221-30 [6089920] Mutat Res. 1986 Jul;171(1):31-41 [3724781] Chir Pediatr. 1987;28(2):97-101 [3040281] Cancer Res. 1988 May 15;48(10):2788-92 [2965969] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Biometrics. 1988 Jun;44(2):417-31 [3390507] Breast Cancer Res Treat. 1989 Jan;13(1):61-9 [2495831] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7505-9 [2798421] Anticancer Res. 1990 Mar-Apr;10(2A):337-42 [2189360] Acta Anat (Basel). 1991;140(2):97-103 [1867061] Environ Mol Mutagen. 1992;19 Suppl 21:2-141 [1541260] Cancer Res. 1992 May 15;52(10):2977-9 [1316232] Environ Mol Mutagen. 1993;21(2):160-79 [8444144] Carcinogenesis. 1995 Jun;16(6):1329-33 [7788850] Carcinogenesis. 1995 Dec;16(12):2893-8 [8603461] Toxicol Pathol. 1995 Sep-Oct;23(5):591-605 [8578102] Fundam Appl Toxicol. 1996 Jul;32(1):102-8 [8812243] Toxicol Pathol. 1998 May-Jun;26(3):428-41 [9608650] Crit Rev Toxicol. 1999 Mar;29(2):169-261 [10213111] JAMA. 1999 Jun 2;281(21):2020-8 [10359391] Curr Opin Pharmacol. 2004 Dec;4(6):614-20 [15525553] J Clin Endocrinol Metab. 2004 Dec;89(12):6235-8 [15579782] J Clin Endocrinol Metab. 2005 Feb;90(2):855-63 [15522925] Hum Reprod Update. 2005 Jul-Aug;11(4):411-23 [15817524] Gynakol Geburtshilfliche Rundsch. 2008;48(1):9-15 [18209494] Br J Pharmacol. 2008 Jun;154(3):502-21 [18500378] Apoptosis. 2008 Aug;13(8):959-71 [18543106] J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):80-6 [18556192] Natl Toxicol Program Tech Rep Ser. 2010 Sep;(560):1, 7-31,33-171 passim [21037592] JAMA. 2000 Feb 9;283(6):779-82 [10683057] Environ Mol Mutagen. 2000;36(3):163-94 [11044899] Arch Intern Med. 2000 Nov 13;160(20):3093-104 [11074738] Fertil Steril. 2002 Apr;77 Suppl 4:S11-8 [12007897] J Clin Endocrinol Metab. 2002 Dec;87(12):5449-54 [12466335] Br J Sports Med. 2003 Jun;37(3):212-8 [12782545] FEMS Immunol Med Microbiol. 2003 Aug 18;38(1):13-22 [12900050] Horm Metab Res. 2004 Jan;36(1):62-6 [14983409] Rep Carcinog. 2002;10:116-9 [15323057] Am J Hematol. 2004 Nov;77(3):257-67 [15495253] Am J Anat. 1965 Nov;117(3):417-31 [4160088] J Anat. 1971 Jan;108(Pt 1):159-68 [4322581] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biometrics. 1977 Jun;33(2):386-9 [884197] Int Rev Cytol. 1977;50:333-96 [332658] Cell Tissue Res. 1978 Nov 20;194(2):269-77 [728964] Biol Reprod. 1979 Sep;21(2):455-63 [486667] Mutat Res. 1981 Mar;91(2):93-8 [7019696] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.05.026 ER - TY - JOUR T1 - Use of Taiwanese Ropy Fermented Milk (TRFM) and Lactococcus lactis subsp. cremoris Isolated from TRFM in Manufacturing of Functional Low-Fat Cheeses AN - 1349423188; 15930672 AB - Abstract: The purpose of this study was to manufacture new functional low-fat cheeses using Taiwanese ropy fermented milk (TRFM) and Lactococcus lactis subsp. cremoris strains isolated from TRFM. After 28 d of ripening and storage, the viable populations of lactic acid bacteria (LAB) in the low-fat cheeses made with L. lactis subsp. cremoris TL1 (TL1), L. lactis subsp. cremoris TL4 (TL4), and TRFM still maintained above 108 CFU/g. The low-fat cheeses made with TL1 and TRFM showed higher moisture contents than the cheeses made with TL4, full-fat, and low-fat cheese controls. The low-fat cheeses made with TL1 and TL4 had higher customer preferential scores similar to full-fat cheese control in the sensory evaluation. Additionally, the low-fat cheeses fermented with TL1, TL4, and TRFM for 4 h had higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging and ferrous ion-chelating abilities than the cheeses fermented with the starters for 8 h, full-fat, and low-fat cheese controls. A better angiotensin-converting enzyme (ACE) inhibition activity was also observed in the low-fat cheeses made with TL1, TL4, and TRFM than that in the full-fat and low-fat cheese controls during ripening and storage period. Practical Application: As health-conscious consumers continue to seek low-fat alternatives in their diets, there remain strong interests for the dairy industry to develop low-fat cheeses to meet the demands. This study clearly demonstrated that the low-fat cheeses fermented with TL1 for 4 h showed a better overall acceptability and possessed antioxidative abilities and ACE inhibitory activities than other cheeses tested in this study. By improving its flavor and investigating the possible mechanisms of its functionalities in the future, this low-fat cheese might possibly be commercialized and give a positive impact on cheese consumption in the future. JF - Journal of Food Science AU - Chiang, Ming-Lun AU - Chen, Hsi-Chia AU - Wang, Sheng-Yao AU - Hsieh, Yueh-Ling AU - Chen, Ming-Ju AD - Author Chiang is with Dept. of Tourism and Hospitality, Kainan Univ., Taoyuan, Taiwan. Author H-C Chen is with Food and Drug Administration, Dept. of Health, Executive Yuan, Taipei, Taiwan. Authors Wang, Hsieh, and M-J Chen are with Dept. of Animal Science and Technology, author Wang is also with Experimental Farm, and author M-J Chen is also with Center of Biotechnology, Natl. Taiwan Univ., Taipei, Taiwan. Direct inquiries to author M-J Chen, cmj@ntu.edu.tw Y1 - 2011/09// PY - 2011 DA - September 2011 SP - M504 EP - M510 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 76 IS - 7 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Diets KW - Peptidyl-dipeptidase A KW - Lactococcus lactis KW - Flavor KW - Milk KW - Sensory evaluation KW - Lactic acid bacteria KW - Cheese KW - Ripening KW - Dairy industry KW - Colony-forming cells KW - Consumers KW - J 02330:Biochemistry KW - A 01330:Food Microbiology KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1349423188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Use+of+Taiwanese+Ropy+Fermented+Milk+%28TRFM%29+and+Lactococcus+lactis+subsp.+cremoris+Isolated+from+TRFM+in+Manufacturing+of+Functional+Low-Fat+Cheeses&rft.au=Chiang%2C+Ming-Lun%3BChen%2C+Hsi-Chia%3BWang%2C+Sheng-Yao%3BHsieh%2C+Yueh-Ling%3BChen%2C+Ming-Ju&rft.aulast=Chiang&rft.aufirst=Ming-Lun&rft.date=2011-09-01&rft.volume=76&rft.issue=7&rft.spage=M504&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2011.02320.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Document feature - figure 2 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Peptidyl-dipeptidase A; Diets; Ripening; Flavor; Milk; Sensory evaluation; Colony-forming cells; Dairy industry; Consumers; Lactic acid bacteria; Cheese; Lactococcus lactis DO - http://dx.doi.org/10.1111/j.1750-3841.2011.02320.x ER - TY - JOUR T1 - Facemask Use by Children During Infectious Disease Outbreaks AN - 1257779275; 17458535 AB - An overview of available literature on the use of protective facemasks by children for protection from respiratory infectious agents reveals relatively few articles dealing specifically with the topic, despite their use during recent outbreaks (eg, severe acute respiratory syndrome, pandemic influenza). Little is known about the physiological and psychological burdens imposed by these devices and a child's ability to correctly use and tolerate them. This article focuses on the myriad issues associated with protective facemask use by children in the hope of educating public health personnel, healthcare professionals, and families on their limitations and associated risks, and in the hope of fostering much-needed research. JF - Biosecurity and Bioterrorism AU - Roberge, R AD - Technology Research Branch, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA, dtn0@cdc.gov Y1 - 2011/09/01/ PY - 2011 DA - 2011 Sep 01 SP - 225 EP - 231 VL - 9 IS - 3 SN - 1538-7135, 1538-7135 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Children KW - Disasters KW - Influenza KW - Medical personnel KW - Outbreaks KW - Psychology KW - Public health KW - bioterrorism KW - severe acute respiratory syndrome KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257779275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosecurity+and+Bioterrorism&rft.atitle=Facemask+Use+by+Children+During+Infectious+Disease+Outbreaks&rft.au=Roberge%2C+R&rft.aulast=Roberge&rft.aufirst=R&rft.date=2011-09-01&rft.volume=9&rft.issue=3&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Biosecurity+and+Bioterrorism&rft.issn=15387135&rft_id=info:doi/10.1089%2Fbsp.2011.0009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2013-01-11 N1 - SubjectsTermNotLitGenreText - Influenza; Psychology; severe acute respiratory syndrome; bioterrorism; Disasters; Outbreaks; Children; Medical personnel; Public health DO - http://dx.doi.org/10.1089/bsp.2011.0009 ER - TY - JOUR T1 - Cloning and partial characterization of a novel hemolysin gene of Vibrio tubiashii and the development of a PCR-based detection assay AN - 1038602695; 16957626 AB - Vibrio tubiashii expresses virulence factors, such as a vulnificolysin-like hemolysin or cytolysin and a zinc metalloprotease, similar to those of other pathogenic vibrios. In this study, we report the cloning of a novel hemolysin gene of V. tubiashii in Escherichia coli. A V. tubiashii gene library was screened for hemolytic activity on sheep blood agar. Three hemolytic clones pGem:hly1, pGem:hly2, and pGem:hly3 were sequenced, and the sequences showed a strong homology to the ribA gene coding for guanosine triphosphate cyclohydrolase II (GCH II), required for riboflavin biosynthesis and reported to be responsible for hemolytic activity in Helicobacter pylori. The plasmids pGem:hly1 and pGem:hly3 when introduced into E. coli BSV18 (ribA18::Tn5) were able to restore growth of strain BSV18 in a medium without riboflavin and also produced hemolytic activity on blood agar. PCR primers based on the cloned hly-ribA sequence were tested using 23 different Vibrio strains representing 10 different species. Amplification of ribA gene locus only occurred with V. tubiashii strains. In summary, our results indicate that we have cloned a ribA homolog of V. tubiashii that imparts hemolytic activity to E. coli clones, and primers based on this gene locus might be useful as a species-specific identification tool for V. tubiashii.Original Abstract: Vibrio tubiashii exprime des facteurs de virulence dont une hemolysine ou cytolysine apparentee a la vulnificolysine et une metalloprotease a zinc, similaires a celles d'autres Vibrios pathogenes. Dans cette etude, nous rapportons le clonage d'un nouveau gene d'hemolysine de V. tubiashii chez Escherichia coli. Une banque genique de V. tubiashii a ete criblee en fonction d'une activite hemolytique sur gelose au sang de mouton. Trois clones hemolytiques, pGem :hly1, pGem :hly2 et pGem :hly3 ont ete sequences, et les sequences obtenues montraient une forte homologie avec le gene ribA codant la GTP cyclohydrolase II (GCH II), requise pour la synthese de riboflavine et rapportee comme responsable de l'activite hemolytique chez Helicobacter pylori. Les plasmides pGem :hly1 et pGem :hly3, lorsqu'introduits chez E. coli BSV18 (ribA18 ::Tn5), etaient capables de restaurer la croissance de BSV18 dans un milieu sans riboflavine et produisaient aussi une activite hemolytique sur une gelose au sang. Des amorces PCR derivees de la sequence clonee hly-ribA ont ete testees sur 23 souches differentes de Vibrio representant 10 especes differentes. L'amplification du locus genique ribA n'etait obtenue qu'avec les souches de V. tubiashii. En resume, nos resultats indiquent que nous avons clone l'homologue de ribA chez V. tubiashii qui confere une activite hemolytique aux clones d'E. coli, et que les amorces derivees de la sequence de ce locus genique pourraient etre utiles comme outil d'identification specifique a l'espece chez V. tubiashii. JF - Canadian Journal of Microbiology/Revue Canadienne de Microbiologie AU - Sathyamoorthy, Venugopal AU - Datta, Atin R AU - Lee, Clara J AU - Kothary, Mahendra H AU - McCardell, Barbara A AU - Tall, Ben D AD - MOD-1 Facility, Virulence Mechanisms Branch, (HFS-025), Division of Virulence Assessment, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA., Venugopal.Sathyamoorthy@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 714 EP - 721 PB - NRC Research Press VL - 57 IS - 9 SN - 0008-4166, 0008-4166 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Agar KW - Blood KW - Cadmium KW - Gene libraries KW - Guanosine KW - Hemolysins KW - Homology KW - Metalloproteinase KW - Plasmids KW - Polymerase chain reaction KW - Primers KW - Riboflavin KW - Zinc KW - cytolysins KW - ribA gene KW - virulence factors KW - Helicobacter pylori KW - Vibrio tubiashii KW - Escherichia coli KW - Vibrio KW - J 02410:Animal Diseases KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038602695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Journal+of+Microbiology%2FRevue+Canadienne+de+Microbiologie&rft.atitle=Cloning+and+partial+characterization+of+a+novel+hemolysin+gene+of+Vibrio+tubiashii+and+the+development+of+a+PCR-based+detection+assay&rft.au=Sathyamoorthy%2C+Venugopal%3BDatta%2C+Atin+R%3BLee%2C+Clara+J%3BKothary%2C+Mahendra+H%3BMcCardell%2C+Barbara+A%3BTall%2C+Ben+D&rft.aulast=Sathyamoorthy&rft.aufirst=Venugopal&rft.date=2011-09-01&rft.volume=57&rft.issue=9&rft.spage=714&rft.isbn=&rft.btitle=&rft.title=Canadian+Journal+of+Microbiology%2FRevue+Canadienne+de+Microbiologie&rft.issn=00084166&rft_id=info:doi/10.1139%2Fw11-058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Number of references - 23 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Agar; virulence factors; Plasmids; Metalloproteinase; Blood; Homology; Riboflavin; cytolysins; Gene libraries; Zinc; Polymerase chain reaction; Primers; Cadmium; Guanosine; Hemolysins; ribA gene; Helicobacter pylori; Vibrio; Escherichia coli; Vibrio tubiashii DO - http://dx.doi.org/10.1139/w11-058 ER - TY - JOUR T1 - Association of Shift Work With Physical Activity Among Police Officers The Buffalo Cardio-Metabolic Occupational Police Stress Study AN - 1020837278; 15775768 AB - Objective: To examine relations of shift work with occupational, sports, and household physical activity (PA) among police officers. Methods: Self-reported PA was assessed among 350 male and female officers (aged 27 to 66). Day, afternoon, or midnight shift was identified from daily payroll records. Results: Shift work was associated with prevalence of hard-intensity (occupational and sport) PA among men, and very hard-intensity sport PA among women, with afternoon workers reporting the highest prevalence. Shift work was independently associated with total hours of hard-intensity PA among men and very hard-intensity PA among women, with afternoon workers reporting the most hours. Conclusion: Results indicated that hard and very hard-intensity PA varied significantly across shifts with afternoon workers being the most active. JF - Journal of Occupational and Environmental Medicine AU - Ma, C C AU - Burchfiel, C M AU - Fekedulegn, D AU - Andrew, ME AU - Charles, LE AU - Gu, J K AU - Mnatsakanova, A AU - Violanti, J M AD - National Institute for Occupational Safety and Health, HELD/BEB, MS L-4050, 1095 Willowdale Rd, Morgantown, WV 26505, USA, iia4@cdc.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1030 EP - 1036 VL - 53 IS - 9 SN - 1076-2752, 1076-2752 KW - Physical Education Index; Health & Safety Science Abstracts KW - shift work KW - Men KW - Women KW - Stress KW - Exercise KW - working conditions KW - Physical stress KW - police KW - Households KW - Objectives KW - physical activity KW - Police KW - Women (sports) KW - H 1000:Occupational Safety and Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020837278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Association+of+Shift+Work+With+Physical+Activity+Among+Police+Officers+The+Buffalo+Cardio-Metabolic+Occupational+Police+Stress+Study&rft.au=Ma%2C+C+C%3BBurchfiel%2C+C+M%3BFekedulegn%2C+D%3BAndrew%2C+ME%3BCharles%2C+LE%3BGu%2C+J+K%3BMnatsakanova%2C+A%3BViolanti%2C+J+M&rft.aulast=Ma&rft.aufirst=C&rft.date=2011-09-01&rft.volume=53&rft.issue=9&rft.spage=1030&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31822589f9 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Physical stress; Men; Objectives; Women; Exercise; Police; Women (sports); shift work; police; Households; Stress; physical activity; working conditions DO - http://dx.doi.org/10.1097/JOM.0b013e31822589f9 ER - TY - GEN T1 - Children with Special Health Care Needs in Context: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007 AN - 1018480004; ED530916 AB - This chartbook uses the 2007 National Survey of Children's Health (NSCH) to report on recent findings on children with special health care needs (CSHCN) in the United States. The NSCH provides a unique view of CSHCN in the context of where they live, play and go to school. It also allows comparisons to children without special health care needs. The 2007 NSCH is a national, parent-reported telephone survey sponsored with funding and direction from the Health Resources and Services Administration's Maternal and Child Health Bureau and conducted by the Centers for Disease Control and Prevention's National Center for Health Statistics. The survey, also conducted in 2003 and again in 2011, provides a consistent source of data on the health, community and family-related experiences of children with and without special health care needs in the nation and in each state. The 2007 version of the NSCH represents the most recent national and state-representative data about CSHCN and children without special health care needs (non-CSHCN). All of the estimates presented here are based on parents' reports, and only those differences that are statistically significant are included. This chartbook both reports on topics not addressed in other national surveys on CSHCN and provides a comparison of CSHCN in the United States to those children who do not have ongoing special health needs, with specific attention to the following focus areas: (1) Health Behaviors and Risks; (2) Insurance, Access and Quality of Care; (3) Home and Daily Routines; (4) Family Well-Being and Relationships; (5) School, Friends and Community; and (6) Summary indicators of health care quality, the home environment, and the neighborhood and school environment. In addition, the chartbook contains a State Data section which shows many indicators for each of the 50 states and the District of Columbia. Additional information about the chartbook's sources and analysis can be found in the Technical Appendix. (Contains 27 endnotes.) [For related reports, see "The Health and Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530918); "The Health and Well-Being of Children in Rural Areas: A Portrait of the Nation 2007. The National Survey of Children's Health" (ED530919); and "The Mental and Emotional Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health" (ED530917).] Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 101 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - United States KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Program Effectiveness KW - Well Being KW - Child Health KW - Social Support Groups KW - Family Relationship KW - National Surveys KW - Rural Areas KW - Health Behavior KW - Program Evaluation KW - Access to Health Care KW - Social Indicators KW - Context Effect KW - Family Environment KW - Special Needs Students KW - Risk KW - Telephone Surveys KW - Health Needs KW - Educational Environment KW - Health Insurance KW - State Surveys KW - Parent Attitudes KW - Statistical Significance KW - Special Health Problems KW - Statistical Surveys KW - State Standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018480004?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - The Health and Well-Being of Children in Rural Areas: A Portrait of the Nation 2007. The National Survey of Children's Health AN - 1018479821; ED530919 AB - The National Survey of Children's Health (NSCH) provides a unique resource with which to analyze the health status, health care use, activities, and family and community environments experienced by children in rural and urban areas. The NSCH was designed to measure the health and well-being of children from birth through age 17 in the United States while taking into account the environments in which they grow and develop. Conducted for the second time in 2007, the survey collected information from parents on their children's health, including oral, physical, and mental health, health care use and insurance status, and social activities and well-being. Aspects of the child's environment that were assessed in the survey include family structure, poverty level, parental health and well-being, and community surroundings. The survey was supported and developed by the U.S. Department of Health and Human Services, Health Resources and Services Administration (HRSA), Maternal and Child Health Bureau (MCHB) and was conducted by the Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). This book presents information about the health and health care of children by location and by major demographic characteristics such as age, sex, race and ethnicity, and household income as compared to the Federal poverty level. Unless otherwise noted, all graphs provide information on all children from birth through age 17. Children were classified by race and ethnicity in seven categories: non-Hispanic White, non-Hispanic Black, Hispanic (in homes where English is the primary spoken language), Hispanic (in homes where Spanish is the primary spoken language), non-Hispanic American Indian/Alaska Native (alone or in combination with other races), multiracial, and single races other than those listed above. All comparisons presented in the text of this chartbook are statistically significant at the 0.05 level; however, unless otherwise specified, other differences presented in the graphs have not been tested for significance and should be interpreted with caution. The Technical Appendices at the end of this book presents information about the survey methodology and sample. [For related reports, see "Children with Special Health Care Needs in Context: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530916); "The Health and Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530918); and "The Mental and Emotional Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health" (ED530917).] Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 51 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - United States KW - Alaska KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Family Characteristics KW - Well Being KW - Family Structure KW - National Surveys KW - Rural Areas KW - Income KW - Community Surveys KW - Federal Programs KW - Health Conditions KW - Statistical Data KW - Data Analysis KW - Age Differences KW - Social Indicators KW - Gender Differences KW - Ethnicity KW - Neighborhoods KW - Racial Differences KW - Children KW - Community Influence KW - Health Services KW - Health Needs KW - Human Services KW - Educational Environment KW - Health Insurance KW - Poverty KW - Learning Activities KW - Family Income KW - Health Activities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018479821?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Excess Risk of Head and Chest Colds Among Teachers and Other School Workers AN - 1018377920; 201212008 AB - BACKGROUND: Work-related injuries and illnesses in the educational services sector have not been well studied. This analysis examined whether teachers and other school workers are at higher risk of head/chest cold compared to all other workers in the United States. METHODS: Seven years (1998-2004) of National Health Interview Survey data on currently employed workers were combined to provide a basis for estimating the incidence proportion of head/chest cold. RESULTS: The adjusted odds ratio for head/chest cold was significantly elevated for teachers and other workers employed at schools compared to all other workers. When examined by month, an excess of increased head/chest cold risk during the school year suggested that a portion of head/chest cold among teachers and other school workers is attributable to their workplace, perhaps due to close contact with students at school. CONCLUSION: Head/chest cold, a surrogate for acute respiratory infection, was more common among school workers during the school year and less common during July than for all other workers in the United States. Targeted training for school workers and students may be beneficial to reduce work-related exposure to viruses and bacteria that infect the respiratory system. Adapted from the source document. JF - Journal of School Health AU - Tak, SangWoo AU - Groenewold, Matthew AU - Alterman, Toni AU - Park, Robert M AU - Calvert, Geoffrey M AD - Epidemiologist, National Institute for Occupational Safety and Health, the Centers for Disease Control and Prevention, 4676 Columbia Pkwy, R-17, Cincinnati, OH 45226 Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 560 EP - 565 PB - Wiley-Blackwell, UK VL - 81 IS - 9 SN - 0022-4391, 0022-4391 KW - Industrial accidents KW - Viruses KW - Teachers KW - Respiratory diseases KW - Surrogates KW - Chest KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018377920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Excess+Risk+of+Head+and+Chest+Colds+Among+Teachers+and+Other+School+Workers&rft.au=Tak%2C+SangWoo%3BGroenewold%2C+Matthew%3BAlterman%2C+Toni%3BPark%2C+Robert+M%3BCalvert%2C+Geoffrey+M&rft.aulast=Tak&rft.aufirst=SangWoo&rft.date=2011-09-01&rft.volume=81&rft.issue=9&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2011.00627.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Chest; Teachers; Industrial accidents; Surrogates; Respiratory diseases; Viruses DO - http://dx.doi.org/10.1111/j.1746-1561.2011.00627.x ER - TY - JOUR T1 - The Fog of Mediacare: How Democrats intend to use it again to confuse voters and get themselves reelected AN - 1018339868; 2011-200599 AB - The central issue of the 2012 election will be Medicare. For those who care about the health of Americas seniors and the fiscal health of the nation, this is not good news. Recent statements and actions by Pelosi and other Democrats reveal that the Democratic Party believes that making political use of Medicare is more important than ensuring the viability of the program itself. The eagerness to exploit the politics of Medicare is already influencing the Democratic partys approach to policy. Adapted from the source document. JF - Commentary AU - Troy, Tevi AD - Hudson Institute and the former deputy secretary of Health and Human Services Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 46 EP - 50 PB - American Jewish Committee, New York, NY VL - 132 IS - 2 SN - 0010-2601, 0010-2601 KW - Health conditions and policy - Health and health policy KW - Politics - Politics and policy-making KW - Politics - Political parties and groups KW - Politics - Elections and voting KW - Banking and public and private finance - Public finance KW - United States KW - Elections KW - Politics KW - Medicare KW - Health policy KW - Democratic party (United States) KW - Fiscal policy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018339868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Commentary&rft.atitle=The+Fog+of+Mediacare%3A+How+Democrats+intend+to+use+it+again+to+confuse+voters+and+get+themselves+reelected&rft.au=Troy%2C+Tevi&rft.aulast=Troy&rft.aufirst=Tevi&rft.date=2011-09-01&rft.volume=132&rft.issue=2&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Commentary&rft.issn=00102601&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medicare; Politics; Democratic party (United States); Health policy; Elections; United States; Fiscal policy ER - TY - JOUR T1 - Evaluation of protein expression in bovine bronchoalveolar fluid following challenge with Mannheimia haemolytica AN - 1017983702; 16717048 AB - Proteomics analysis of bovine bronchoalveolar fluid (BAF) following induction of pneumonia with Mannheimia haemolytica using nanoflow liquid chromatography coupled with tandem mass spectrometry (nanoLC-MS/MS) resulted in the identification of 88 unique proteins. Proteins detected in BAF included antimicrobial peptides (AMPs), complement factors, acute-phase proteins, protease inhibitors, and proteins involved in oxidation-reduction. Notwithstanding biological variation, differences in relative protein abundance, determined using normalized peptide counts, were detected for select proteins in BAF from genuinely infected versus sham-infected animals. To demonstrate the applicability of using normalized peptide counts to assess protein expression trends, LC-MS/MS data for the acute-phase protein haptoglobin (HPT) were compared with ELISA data, and statistical evaluation of the relationship between the data revealed a strong measure of association. Differences were detected between sham- and genuinely infected animals for haptoglobin, as well as the AMPs cathelicidin-1 and cathelicidin-4, and inter-trypsin inhibitor heavy chain-4, a fairly novel protein involved in the acute phase response. Though the small sample size limited the scope of the inferences, the results indicate the likely importance of AMPs and acute-phase proteins during respiratory infection, and provide additional information regarding potential mechanisms involved in the bovine mucosal barrier defense. JF - Proteomics AU - Boehmer, Jamie L AU - Degrasse, Jeffrey A AU - Lancaster, Vicki A AU - McFarland, Melinda A AU - Callahan, John H AU - Ward, Jeffrey L AD - U.S. Food and Drug Administration Center for Veterinary Medicine, Laurel, MD, USA, jamie.boehmer@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 3685 EP - 3697 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 11 IS - 18 SN - 1615-9853, 1615-9853 KW - Biotechnology and Bioengineering Abstracts KW - Acute phase substances KW - Alveoli KW - Antimicrobial peptides KW - Bronchus KW - Data processing KW - Enzyme-linked immunosorbent assay KW - Haptoglobin KW - Infection KW - Liquid chromatography KW - Mass spectroscopy KW - Mucosa KW - Pneumonia KW - Proteinase inhibitors KW - Statistics KW - proteomics KW - Mannheimia haemolytica KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017983702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Evaluation+of+protein+expression+in+bovine+bronchoalveolar+fluid+following+challenge+with+Mannheimia+haemolytica&rft.au=Boehmer%2C+Jamie+L%3BDegrasse%2C+Jeffrey+A%3BLancaster%2C+Vicki+A%3BMcFarland%2C+Melinda+A%3BCallahan%2C+John+H%3BWard%2C+Jeffrey+L&rft.aulast=Boehmer&rft.aufirst=Jamie&rft.date=2011-09-01&rft.volume=11&rft.issue=18&rft.spage=3685&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.201000710 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pmic.201000710/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-01-11 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Data processing; Statistics; Mucosa; Proteinase inhibitors; Infection; Alveoli; Mass spectroscopy; Acute phase substances; Haptoglobin; Bronchus; Liquid chromatography; proteomics; Antimicrobial peptides; Pneumonia; Mannheimia haemolytica DO - http://dx.doi.org/10.1002/pmic.201000710 ER - TY - JOUR T1 - A new methane control and prediction software suite for longwall mines AN - 1017949511; 2012-051245 AB - This paper presents technical and application aspects of a new software suite, MCP (Methane Control and Prediction), developed for addressing some of the methane and methane control issues in longwall coal mines. The software suite consists of dynamic link library (DLL) extensions to MS-Access (super TM,) written in C++. In order to create the DLLs, various statistical, mathematical approaches, prediction and classification artificial neural network (ANN) methods were used. The current version of MCP suite (version 1.3) discussed in this paper has four separate modules that (a) predict the dynamic elastic properties of coal-measure rocks, (b) predict ventilation emissions from longwall mines, (c) determine the type of degasification system that needs to be utilized for given situations and (d) assess the production performance of gob gas ventholes that are used to extract methane from longwall gobs. These modules can be used with the data from basic logs, mining, longwall panel, productivity, and coal bed characteristics. The applications of these modules separately or in combination for methane capture and control related problems will help improve the safety of mines. The software suite's version 1.3 is discussed in this paper. Currently, it's new version 2.0 is available and can be downloaded from http://www.cdc.gov/niosh/mining/products/product180.htm free of charge. The models discussed in this paper can be found under "ancillary models" and under "methane prediction models" for specific U.S. conditions in the new version. JF - Computers & Geosciences AU - Dougherty, Heather N AU - Karacan, C Ozgen Y1 - 2011/09// PY - 2011 DA - September 2011 SP - 1490 EP - 1500 PB - Elsevier, Amsterdam VL - 37 IS - 9 SN - 0098-3004, 0098-3004 KW - mining KW - degasification KW - geologic hazards KW - underground mining KW - elastic properties KW - data processing KW - aliphatic hydrocarbons KW - rock mechanics KW - air pollution KW - ventilation KW - environmental management KW - sedimentary rocks KW - coal KW - neural networks KW - mines KW - methane KW - statistical analysis KW - coal mines KW - prediction KW - pollution KW - mechanical properties KW - alkanes KW - emissivity KW - artificial intelligence KW - organic compounds KW - safety KW - longwall mining KW - mathematical methods KW - natural hazards KW - hydrocarbons KW - coal deposits KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017949511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+%26+Geosciences&rft.atitle=A+new+methane+control+and+prediction+software+suite+for+longwall+mines&rft.au=Dougherty%2C+Heather+N%3BKaracan%2C+C+Ozgen&rft.aulast=Dougherty&rft.aufirst=Heather&rft.date=2011-09-01&rft.volume=37&rft.issue=9&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Computers+%26+Geosciences&rft.issn=00983004&rft_id=info:doi/10.1016%2Fj.cageo.2010.09.003 L2 - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5840&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e5198452fad934c6346f38b57511c8e0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 22 N1 - Document feature - illus. incl. 8 tables N1 - Last updated - 2012-06-07 N1 - CODEN - GGEOD5 N1 - SubjectsTermNotLitGenreText - air pollution; aliphatic hydrocarbons; alkanes; artificial intelligence; coal; coal deposits; coal mines; data processing; degasification; elastic properties; emissivity; environmental management; geologic hazards; hydrocarbons; longwall mining; mathematical methods; mechanical properties; methane; mines; mining; natural hazards; neural networks; organic compounds; pollution; prediction; rock mechanics; safety; sedimentary rocks; statistical analysis; underground mining; ventilation DO - http://dx.doi.org/10.1016/j.cageo.2010.09.003 ER - TY - JOUR T1 - Association of General Fatigue With Cellular Immune Indicators Among Healthy White-Collar Employees AN - 1008847697; 15775774 AB - Objective: Although fatigue is a common complaint in the working population, underlying immunological mechanisms are not well understood. This study investigated the association of general fatigue with cellular immune indicators. Methods: A total of 148 healthy white-collar employees (70% men) underwent a blood draw for the measurement of natural killer (NK), B, and T cell counts as well as NK cell cytotoxicity (NKCC) and completed two different fatigue scales, that is, Profile of Mood State (POMS) and Maastricht Questionnaire (MQ). Results: Multiple linear regression analyses revealed that POMS fatigue score was significantly associated with decreases of NK cells ( beta = -.407) and NKCC ( beta = -.215), whereas MQ fatigue score was significantly associated with reduced NK cells ( beta = -.290) but not with NKCC ( beta = -.127). Conclusion: The results suggest that general fatigue may be related to impaired NK cell competency among healthy employees. JF - Journal of Occupational and Environmental Medicine AU - Nakata, A AU - Irie, M AU - Takahashi, M AD - Division of Applied Research and Technology, MS-C24, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA, nakataatky@urnin.ac.jp Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 1078 EP - 1085 VL - 53 IS - 9 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - Inventories KW - Fatigue KW - Lymphocytes B KW - Natural killer cells KW - fatigue KW - Mood KW - Blood KW - Cytotoxicity KW - Regression analysis KW - Lymphocytes T KW - Netherlands, Limburg, Maastricht KW - F 06955:Immunomodulation & Immunopharmacology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008847697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Association+of+General+Fatigue+With+Cellular+Immune+Indicators+Among+Healthy+White-Collar+Employees&rft.au=Nakata%2C+A%3BIrie%2C+M%3BTakahashi%2C+M&rft.aulast=Nakata&rft.aufirst=A&rft.date=2011-09-01&rft.volume=53&rft.issue=9&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e318229a938 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Mood; Inventories; Blood; Cytotoxicity; Fatigue; Lymphocytes B; Lymphocytes T; Regression analysis; Natural killer cells; fatigue; Netherlands, Limburg, Maastricht DO - http://dx.doi.org/10.1097/JOM.0b013e318229a938 ER - TY - JOUR T1 - Suitable top concentration for tests with mammalian cells: mouse lymphoma assay workgroup. AN - 874481776; 21514400 AB - The Mouse Lymphoma Expert Workgroup of the International Workshop for Genotoxicity Tests (IWGT) met in Basel, Switzerland in August of 2009. The Workgroup (WG) was tasked with discussing the appropriate top concentration for non-pharmaceuticals that would be required for the conduct of the mouse lymphoma assay (MLA) when sufficient cytotoxicity [to between 10 and 20% relative total growth (RTG)] has not been attained. The WG approached this task by (1) enumerating the various regulatory decisions/use for MLA data, (2) discussing the appropriate assays to which MLA data and assay performance should be compared and (3) discussing all the proposals put forth concerning the top concentration for non-pharmaceuticals. In addition, one of the members presented a summary of a re-evaluation of the National Toxicology Program MLA data using the IWGT harmonized guidance that was underway as a separate (non IWGT) activity, being conducted by two members of the Expert WG. The WG was asked to vote on each of the various proposals for top concentration for when cytotoxicity is not concentration limiting. While there was general agreement that the top concentration for non-pharmaceuticals should be re-evaluated and likely lowered from the current recommended levels, there was no agreement on a specific new recommendation. Published by Elsevier B.V. JF - Mutation research AU - Moore, Martha M AU - Honma, Masamitsu AU - Clements, Julie AU - Awogi, Takumi AU - Douglas, George R AU - van Goethem, Freddy AU - Gollapudi, Bhaskar AU - Kimura, Aoi AU - Muster, Wolfgang AU - O'Donovan, Mike AU - Schoeny, Rita AU - Wakuri, Shinobu AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U. S. Food and Drug Administration, HFT-120, 3900 NCTR Rd., Jefferson, AR, USA. Martha.Moore@fda.hhs.gov Y1 - 2011/08/16/ PY - 2011 DA - 2011 Aug 16 SP - 84 EP - 86 VL - 723 IS - 2 SN - 0027-5107, 0027-5107 KW - Index Medicus KW - Professional Autonomy KW - Animals KW - Mice KW - Lymphoma KW - Mutagenicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874481776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Suitable+top+concentration+for+tests+with+mammalian+cells%3A+mouse+lymphoma+assay+workgroup.&rft.au=Moore%2C+Martha+M%3BHonma%2C+Masamitsu%3BClements%2C+Julie%3BAwogi%2C+Takumi%3BDouglas%2C+George+R%3Bvan+Goethem%2C+Freddy%3BGollapudi%2C+Bhaskar%3BKimura%2C+Aoi%3BMuster%2C+Wolfgang%3BO%27Donovan%2C+Mike%3BSchoeny%2C+Rita%3BWakuri%2C+Shinobu&rft.aulast=Moore&rft.aufirst=Martha&rft.date=2011-08-16&rft.volume=723&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-15 N1 - Date created - 2011-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2011.04.001 ER - TY - JOUR T1 - Monitoring for teratogenic signals: pregnancy registries and surveillance methods. AN - 878593936; 21766431 AB - Pregnant women should have access to medications that have been adequately studied for use to facilitate evidence-based risk-benefit discussions with their health care providers. Pregnant women experience acute medical emergencies, have existing conditions that require continued medical treatment or may develop pregnancy-induced conditions, making drug use during pregnancy unavoidable. Drug labeling is the primary source of information about a drug's use. The safety and efficacy data found in the label is derived from well-controlled clinical trials conducted prior to a drug's approval. However, pregnant women are rarely enrolled in clinical trials unless a product is specifically indicated for a pregnancy-related condition. Consequently, information regarding a product's use during pregnancy is usually collected postapproval. Current data collection tools include pregnancy exposure registries, retrospective cohort studies, pregnancy surveillance programs, case-control studies, spontaneous reports of adverse events and case reports. Each tool has strengths and limitations in its ability to detect teratogenic signals. Combinations of different sources of data are necessary to acquire the most complete picture of potential teratogenic risk, as no single method can capture all desired data to help pregnant patients and women of child bearing potential make appropriate risk benefits decisions along with their health care providers. Published 2011 Wiley-Liss, Inc. JF - American journal of medical genetics. Part C, Seminars in medical genetics AU - Howard, Tammie B AU - Tassinari, Melissa S AU - Feibus, Karen B AU - Mathis, Lisa L AD - Pediatric and Maternal Health, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA. . Y1 - 2011/08/15/ PY - 2011 DA - 2011 Aug 15 SP - 209 EP - 214 VL - 157C IS - 3 KW - Teratogens KW - 0 KW - Index Medicus KW - Adverse Drug Reaction Reporting Systems KW - Humans KW - Pregnancy Complications -- drug therapy KW - Data Collection KW - Drug Labeling KW - Female KW - Risk Assessment KW - Pregnancy KW - Registries KW - Drug-Related Side Effects and Adverse Reactions KW - Teratogens -- toxicity KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878593936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.atitle=Monitoring+for+teratogenic+signals%3A+pregnancy+registries+and+surveillance+methods.&rft.au=Howard%2C+Tammie+B%3BTassinari%2C+Melissa+S%3BFeibus%2C+Karen+B%3BMathis%2C+Lisa+L&rft.aulast=Howard&rft.aufirst=Tammie&rft.date=2011-08-15&rft.volume=157C&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics.+Part+C%2C+Seminars+in+medical+genetics&rft.issn=1552-4876&rft_id=info:doi/10.1002%2Fajmg.c.30304 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-23 N1 - Date created - 2011-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajmg.c.30304 ER - TY - JOUR T1 - Recombinant HA1 produced in E. coli forms functional oligomers and generates strain-specific SRID potency antibodies for pandemic influenza vaccines AN - 885050816; 15458199 AB - Vaccine production and initiation of mass vaccination is a key factor in rapid response to new influenza pandemic. During the 2009-2010 H1N1 pandemic, several bottlenecks were identified, including the delayed availability of vaccine potency reagents. Currently, antisera for the single-radial immunodiffusion (SRID) potency assay are generated in sheep immunized repeatedly with HA released and purified after bromelain-treatment of influenza virus grown in eggs. This approach was a major bottleneck for pandemic H1N1 (H1N1pdm09) potency reagent development in 2009. Alternative approaches are needed to make HA immunogens for generation of SRID reagents in the shortest possible time. In this study, we found that properly folded recombinant HA1 globular domain (rHA1) from several type A viruses including H1N1pdm09 and two H5N1 viruses could be produced efficiently using a bacterial expression system and subsequent purification. The rHA1 proteins were shown to form functional oligomers of trimers, similar to virus derived HA, and elicited high titer of neutralizing antibodies in rabbits and sheep. Importantly, the immune sera formed precipitation rings with reference antigens in the SRID assay in a dose-dependent manner. The HA contents in multiple H1N1 vaccine products from different manufacturers (and in several lots) as determined with the rHA1-generated sheep sera were similar to the values obtained with a traditionally generated sheep serum from NIBSC. We conclude that bacterially expressed recombinant HA1 proteins can be produced rapidly and used to generate SRID potency reagents shortly after new influenza strains with pandemic potential are identified. JF - Vaccine AU - Khurana, Surender AU - Larkin, Christopher AU - Verma, Swati AU - Joshi, Manju B AU - Fontana, Juan AU - Steven, Alasdair C AU - King, Lisa R AU - Manischewitz, Jody AU - McCormick, William AU - Gupta, Rajesh K AU - Golding, Hana Y1 - 2011/08/05/ PY - 2011 DA - 2011 Aug 05 SP - 5657 EP - 5665 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 29 IS - 34 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Pandemic influenza KW - Vaccine potency KW - Single-radial immunodiffusion assay KW - H5N1 KW - H1N1 KW - Vaccine KW - Influenza KW - pandemics KW - Antibodies KW - Antisera KW - Influenza virus KW - Immunodiffusion KW - Escherichia coli KW - Vaccines KW - Precipitation KW - Eggs KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885050816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Recombinant+HA1+produced+in+E.+coli+forms+functional+oligomers+and+generates+strain-specific+SRID+potency+antibodies+for+pandemic+influenza+vaccines&rft.au=Khurana%2C+Surender%3BLarkin%2C+Christopher%3BVerma%2C+Swati%3BJoshi%2C+Manju+B%3BFontana%2C+Juan%3BSteven%2C+Alasdair+C%3BKing%2C+Lisa+R%3BManischewitz%2C+Jody%3BMcCormick%2C+William%3BGupta%2C+Rajesh+K%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2011-08-05&rft.volume=29&rft.issue=34&rft.spage=5657&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.06.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Influenza; Antisera; Antibodies; pandemics; Immunodiffusion; Precipitation; Vaccines; Eggs; Influenza virus; Escherichia coli DO - http://dx.doi.org/10.1016/j.vaccine.2011.06.014 ER - TY - JOUR T1 - Estimating the causal effect of low tidal volume ventilation on survival in patients with acute lung injury AN - 940980603; 4280468 AB - Acute lung injury is a condition that is characterized by acute onset of severe hypoxaemia and bilateral pulmonary infiltrates. Patients typically require mechanical ventilation in an intensive care unit. Low tidal volume ventilation (LTVV), which is a time varying dynamic treatment regime, has been recommended as an effective ventilation strategy. This recommendation was based on the results of a randomized clinical trial designed to compare low versus high tidal volume strategies by the Acute Respiratory Distress Syndrome Network. After publication of the trial, some critics focused on the high non-adherence rates in the LTVV arm suggesting that non-adherence occurred because treating physicians felt that deviating from the prescribed regime would improve patients' outcomes. We seek to address this controversy by estimating the survival distribution in the counterfactual setting where all patients assigned to LTVV followed the regime. Inference is based on a fully Bayesian implementation of Robins's G-computation formula. In addition to reanalysing data from the original trial, we also apply our methodology to data from a subsequent trial, which implemented the LTVV regime in both of its study arms and also suffered from non-adherence. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Brower, Roy AU - Wang, Weiwei AU - Scharfstein, Daniel AU - Wang, Chenguang AU - Daniels, Michael AU - Needham, Dale AD - University of Texas ; Johns Hopkins University ; US Food and Drug Administration ; University of Florida Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 475 EP - 496 VL - 60 IS - 4 SN - 0035-9254, 0035-9254 KW - Economics KW - Comparative analysis KW - Causal analysis KW - Statistical models KW - Survival KW - Patients KW - Medical treatment KW - Estimation KW - Methodology KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940980603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Estimating+the+causal+effect+of+low+tidal+volume+ventilation+on+survival+in+patients+with+acute+lung+injury&rft.au=Brower%2C+Roy%3BWang%2C+Weiwei%3BScharfstein%2C+Daniel%3BWang%2C+Chenguang%3BDaniels%2C+Michael%3BNeedham%2C+Dale&rft.aulast=Brower&rft.aufirst=Roy&rft.date=2011-08-01&rft.volume=60&rft.issue=4&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Fj.1467-9876.2010.00757.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4403 7854; 2085 971 2088 10642 2688 2449 10404; 7890 5792 10484; 1512 3865 4025; 9271 7890 5792 10484; 12430; 12230 8163; 2630 971; 7994 DO - http://dx.doi.org/10.1111/j.1467-9876.2010.00757.x ER - TY - JOUR T1 - Assessment of Exposure to PACs in Asphalt Workers: Measurement of Urinary PACs and their Metabolites with an ELISA Kit AN - 926297796; 15719020 AB - An enzyme-linked immunosorbent assay (ELISA) kit made for determination of polycyclic aromatic compounds (PACs) in water was adapted for measuring PACs and their metabolites in urine. This method was then applied to a pilot asphalt worker PAC exposure study. Currently, liquid-liquid extraction with gas chromatography/isotope dilution high-resolution mass spectrometry (GC/HRMS) is the preferred method to determine urinary PAC metabolites. Although sensitive and specific, GC/HRMS is time consuming and costly. The ELISA method had a range from 14-720 ng/ml 1-hydroxypyrene equivalents with a lower limit of detection (LOD) of 14 ng/ml urine. ELISA and GC/HRMS PAC metabolite measurements had a statistically significant correlation and the PAC ELISA results were indicative of potential asphalt exposure. PAC ELISA is promising as a more rapid and less costly routine method for determining worker exposure to PACs in asphalt emissions. JF - Polycyclic Aromatic Compounds AU - Smith, Jerome P AU - Biagini, Raymond E AU - Johnson, Belinda C AU - Olsen, Larry D AU - Mackenzie, Barbara A AU - Robertson, Shirley A AU - Sammons, Deborah L AU - STRILEY, CYNTHIA AF AU - Walker, Cynthia V AU - SNAWDER, JOHN E AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 270 EP - 285 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 31 IS - 4 SN - 1040-6638, 1040-6638 KW - Toxicology Abstracts KW - asphalt KW - biomonitoring KW - ELISA KW - PAC KW - urine KW - Enzyme-linked immunosorbent assay KW - Isotopes KW - Aromatic compounds KW - Asphalt KW - Urine KW - Gas chromatography KW - Statistical analysis KW - Metabolites KW - Occupational exposure KW - Mass spectroscopy KW - 1-Hydroxypyrene KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926297796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Polycyclic+Aromatic+Compounds&rft.atitle=Assessment+of+Exposure+to+PACs+in+Asphalt+Workers%3A+Measurement+of+Urinary+PACs+and+their+Metabolites+with+an+ELISA+Kit&rft.au=Smith%2C+Jerome+P%3BBiagini%2C+Raymond+E%3BJohnson%2C+Belinda+C%3BOlsen%2C+Larry+D%3BMackenzie%2C+Barbara+A%3BRobertson%2C+Shirley+A%3BSammons%2C+Deborah+L%3BSTRILEY%2C+CYNTHIA+AF%3BWalker%2C+Cynthia+V%3BSNAWDER%2C+JOHN+E&rft.aulast=Smith&rft.aufirst=Jerome&rft.date=2011-08-01&rft.volume=31&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Polycyclic+Aromatic+Compounds&rft.issn=10406638&rft_id=info:doi/10.1080%2F10406638.2011.604663 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Isotopes; Enzyme-linked immunosorbent assay; Aromatic compounds; Gas chromatography; Urine; Asphalt; Statistical analysis; Metabolites; Mass spectroscopy; Occupational exposure; 1-Hydroxypyrene DO - http://dx.doi.org/10.1080/10406638.2011.604663 ER - TY - JOUR T1 - The Concept of Voluntary Consent AN - 914787400; 2011-156254 AB - Our primary focus is on analysis of the concept of voluntariness, with a secondary focus on the implications of our analysis for the concept and the requirements of voluntary informed consent. We propose that two necessary and jointly sufficient conditions must be satisfied for an action to be voluntary: intentionality, and substantial freedom from controlling influences. We reject authenticity as a necessary condition of voluntary action, and we note that constraining situations may or may not undermine voluntariness, depending on the circumstances and the psychological capacities of agents. We compare and evaluate several accounts of voluntariness and argue that our view, unlike other treatments in bioethics, is not a value-laden theory. We also discuss the empirical assessment of individuals' perceptions of the degrees of noncontrol and self-control. We propose use of a particular Decision Making Control Instrument. Empirical research using this instrument can provide data that will help establish appropriate policies and procedures for obtaining voluntary consent to research. Adapted from the source document. JF - The American Journal of Bioethics AU - Nelson, Robert M AU - Beauchamp, Tom AU - Miller, Victoria A AU - Reynolds, William AU - Ittenbach, Richard F AU - Luce, Mary Frances AD - U.S. Food and Drug Administration Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 6 EP - 16 PB - Taylor & Francis, Philadelphia PA VL - 11 IS - 8 SN - 1526-5161, 1526-5161 KW - Law and ethics - Health law KW - Human rights - Civil and political rights KW - Law and ethics - Ethics KW - authenticity control decision making informed consent intentionality voluntariness KW - Informed consent KW - Liberty KW - Bioethics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914787400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Bioethics&rft.atitle=The+Concept+of+Voluntary+Consent&rft.au=Nelson%2C+Robert+M%3BBeauchamp%2C+Tom%3BMiller%2C+Victoria+A%3BReynolds%2C+William%3BIttenbach%2C+Richard+F%3BLuce%2C+Mary+Frances&rft.aulast=Nelson&rft.aufirst=Robert&rft.date=2011-08-01&rft.volume=11&rft.issue=8&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2011.583318 LA - English DB - PAIS Index N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Informed consent; Liberty; Bioethics DO - http://dx.doi.org/10.1080/15265161.2011.583318 ER - TY - JOUR T1 - A Review of Missed Opportunities for Prenatal HIV Screening in a Nationwide Sample of Health Facilities in the Indian Health Service AN - 908020782; 201122290 AB - To better serve our patients, we sought to identify missed opportunities for prenatal HIV screening across Indian Health Service and potential ways to increase screening. Twenty-seven of 161 Federal or Tribal IHS health facilities were randomly selected. Each facility received a standardized set of commands to identify the charts of prenatal patients who were not screened for HIV according to the national Health Information Technology (HIT) platform. We reviewed 598 records at 27 sites of prenatal patients who were identified as not screened for HIV during their pregnancy. According to on-site chart review, nearly half (267/598, 45%) had been screened for HIV, and a slight majority (331/598, 55%) had not been screened. Among the 331 pregnant women not screened for HIV, about half had no HIV screening despite having had >=2 prenatal care encounters and no screening exclusions (167/331, 50%). A majority of missed opportunities (118/167, 71%) had prenatal testing for other infectious diseases. Based on these results, the National HIV/AIDS program has encouraged increased bundling of HIV with infectious disease tests in prenatal laboratory panels. Improvements in documentation of HIV screening are expected with the IHS transition to electronic health records. Adapted from the source document. JF - Journal of Community Health AU - Reilley, Brigg AU - Redd, John T AU - Cheek, James AU - Giberson, Scott AD - Division of Epidemiology and Disease Prevention, Indian Health Service, 5300 Homestead Rd, Albuquerque, NM, 87110, USA Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 631 EP - 634 PB - Springer, New York NY VL - 36 IS - 4 SN - 0094-5145, 0094-5145 KW - Screening KW - Antenatal KW - Computerized medical records KW - Laboratories KW - Information technology KW - Health KW - Pregnant women KW - HIV KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908020782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=A+Review+of+Missed+Opportunities+for+Prenatal+HIV+Screening+in+a+Nationwide+Sample+of+Health+Facilities+in+the+Indian+Health+Service&rft.au=Reilley%2C+Brigg%3BRedd%2C+John+T%3BCheek%2C+James%3BGiberson%2C+Scott&rft.aulast=Reilley&rft.aufirst=Brigg&rft.date=2011-08-01&rft.volume=36&rft.issue=4&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-010-9352-4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - HIV; Antenatal; Screening; Pregnant women; Health services; Health; Information technology; Computerized medical records; Laboratories DO - http://dx.doi.org/10.1007/s10900-010-9352-4 ER - TY - JOUR T1 - Utilization of Hospital Emergency Departments for Non-Traumatic Dental Care in New Hampshire, 2001-2008 AN - 908014257; 2011-141388 AB - Hospital Emergency Departments (ED) provide a variety of medical care, some of which is for non-urgent, chronic conditions. We describe the statewide use of hospital ED for selected non-traumatic dental conditions that occurred during 2001-2008 in New Hampshire. Using the administrative hospital discharge dataset for 2001-2007, and provisional 2008 data, we identified all visits for selected dental conditions and calculated age-adjusted rates per 10,000 New Hampshire residents by several socio-demographic characteristics. The Spearman correlation coefficient was used to assess the statistical significance for trend over time. Emergency department visits for non-traumatic dental conditions increased significantly from 11,067 in 2001 to 16,238 visits in 2007 (P < 0.007). There were persistent differences in ED visits by age, county and primary payor, and varying difference by gender. Self-paying individuals and those 15-44 years old were the most frequent ED dental care users. The most frequent dental complains (46%) were diseases of the teeth and supporting structures, diagnostic code ICD-9-CM-525. Dental care associated ED visits have increased in New Hampshire. Individuals seeking dental treatment in ED are not receiving definitive treatment, and they misuse limited resources. Future studies need to determine the specific barriers to timely and effective dental care in dental offices. Ongoing consistent monitoring of ED use for non-traumatic dental conditions is essential. Adapted from the source document. JF - Journal of Community Health AU - Anderson, Ludmila AU - Cherala, Sai AU - Traore, Elizabeth AU - Martin, Nancy R AD - Division of Public Health Services, New Hampshire Department of Health and Human Services, Concord, NH, USA landerson@dhhs.state.nh.us Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 513 EP - 516 PB - Springer, New York NY VL - 36 IS - 4 SN - 0094-5145, 0094-5145 KW - Health conditions and policy - Medicine and health care KW - Social conditions and policy - Community life and organization KW - Health conditions and policy - Hospitals and other health care facilities KW - Health conditions and policy - Diseases and disorders KW - Population groups, population policy, and demographics - Demography and census KW - International relations - International relief and humanitarian assistance KW - New Hampshire KW - Dental service KW - Age KW - Diseases KW - Community health services KW - Emergency medical services KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908014257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Utilization+of+Hospital+Emergency+Departments+for+Non-Traumatic+Dental+Care+in+New+Hampshire%2C+2001-2008&rft.au=Anderson%2C+Ludmila%3BCherala%2C+Sai%3BTraore%2C+Elizabeth%3BMartin%2C+Nancy+R&rft.aulast=Anderson&rft.aufirst=Ludmila&rft.date=2011-08-01&rft.volume=36&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-010-9335-5 LA - English DB - PAIS Index N1 - Date revised - 2011-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Community health services; New Hampshire; Hospitals; Dental service; Emergency medical services; Diseases; Age DO - http://dx.doi.org/10.1007/s10900-010-9335-5 ER - TY - JOUR T1 - Industry and regulatory experience of the glycosylation of monoclonal antibodies AN - 902366065; 15742170 AB - We surveyed 23 antibody-related marketing applications for glycoform analytical and functional information. Our database analysis shows a clear trend of increasing sophistication of analytical methods used to identify and quantify glycans. These have revealed a high degree of complexity and heterogeneity of glycans attached to antibody products. The nature of the complexity is influenced by product type and expression system, and may be associated with functional consequences in some but not all cases. JF - Biotechnology and Applied Biochemistry AU - Read, E K AU - Park, J T AU - Brorson, KA AD - Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20903, USA, kurt.brorson@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 213 EP - 219 PB - Portland Press Ltd., 59 Portland Place London W1N 3AJ United Kingdom VL - 58 IS - 4 SN - 0885-4513, 0885-4513 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Monoclonal antibodies KW - Glycosylation KW - Polysaccharides KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902366065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Applied+Biochemistry&rft.atitle=Industry+and+regulatory+experience+of+the+glycosylation+of+monoclonal+antibodies&rft.au=Read%2C+E+K%3BPark%2C+J+T%3BBrorson%2C+KA&rft.aulast=Read&rft.aufirst=E&rft.date=2011-08-01&rft.volume=58&rft.issue=4&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Applied+Biochemistry&rft.issn=08854513&rft_id=info:doi/10.1002%2Fbab.35 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Databases; Monoclonal antibodies; Glycosylation; Polysaccharides DO - http://dx.doi.org/10.1002/bab.35 ER - TY - JOUR T1 - Distribution of aflatoxins in shelling and milling fractions of naturally contaminated rice AN - 899153474; 15715438 AB - The objective of this study was to determine the distribution of an economically important class of mycotoxins, the aflatoxins, in rice milling fractions. Rice plants grown under field production conditions are frequently infected with types of pathogenic fungi that produce toxic metabolites (mycotoxins). Paddy (seeds) rice from healthy plants in the field was collected and stored on a farm under humid, poorly ventilated conditions. Samples were milled into four fractions (hulls, brown rice, bran and white rice) and analysed for aflatoxins (B1, B2, G1 and G2) using a validated method. Rice fractions from healthy plants, which contained low levels of aflatoxins (less than 1 mu g kg-1), were used to determine the efficiency of the extraction method. Seeds stored under poor conditions were found to be contaminated with aflatoxins B1 and B2 as were the fractions. The sums of AFB1 and AFB2 in stored paddy rice, hulls, brown rice, bran and white rice were 141, 39, 158, 367 and 56 mu g kg-1, respectively. The ratio of aflatoxin B1 and B2 was about 10 : 1. AFG1 and AFG2 were less than 1 mu g kg-1. Thus, brown rice contained 92.9% of the aflatoxins in paddy rice, whereas white rice contained only 27.9%. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Trucksess, M W AU - Abbas, H K AU - Weaver, C M AU - Shier, W T AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1076 EP - 1082 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 28 IS - 8 SN - 1944-0049, 1944-0049 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Risk Abstracts KW - Risk assessment KW - Farms KW - Ventilation KW - Metabolites KW - Food additives KW - Rice fields KW - farms KW - Aflatoxin B1 KW - Seeds KW - Fungi KW - Aflatoxins KW - Oryza sativa KW - Food contamination KW - Mycotoxins KW - Plant extracts KW - K 03330:Biochemistry KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899153474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Distribution+of+aflatoxins+in+shelling+and+milling+fractions+of+naturally+contaminated+rice&rft.au=Trucksess%2C+M+W%3BAbbas%2C+H+K%3BWeaver%2C+C+M%3BShier%2C+W+T&rft.aulast=Trucksess&rft.aufirst=M&rft.date=2011-08-01&rft.volume=28&rft.issue=8&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.576441 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Aflatoxin B1; Food additives; Seeds; Mycotoxins; Farms; Rice fields; Fungi; Aflatoxins; Metabolites; Plant extracts; Food contamination; Ventilation; farms; Oryza sativa DO - http://dx.doi.org/10.1080/19440049.2011.576441 ER - TY - JOUR T1 - Survival of Salmonella Typhi and Shigella dysenteriae in Dehydrated Infant Formula AN - 899136702; 15733630 AB - Powdered infant formula has previously been linked to the transmission of various bacterial pathogens in infants resulting in life-threatening disease and death. Survival studies of 2 common foodborne pathogens,Salmonella entericaserovar Typhi andShigella dysenteriae, in powdered infant formula have not been previously studied despite the potentially devastating consequences from ingestion of these organisms, particularly by newborns, in case of a natural or deliberate contamination event. Therefore, to better predict the risk ofS. Typhi andS. dysenteriaeinfection from consumption of infant formula, the present study was undertaken to determine survival of these microorganisms in dry infant formula under varying atmospheric conditions. A 2-strain cocktail ofS. Typhi and a 3-strain cocktail ofS. dysenteriaewere stored for up to 12 wk in dehydrated infant formula in an ambient air or nitrogen atmosphere. Viable counts ofS.Typhi at 12 wk in infant formula revealed a 2.9- and 1.69-log decrease in ambient air and nitrogen atmosphere, respectively. Viable counts ofS. dysenteriaeat 12 wk in infant formula revealed a 0.81- and 0.42-log decrease in ambient air and nitrogen atmosphere, respectively. These results show thatS.Typhi andS. dysenteriaecan remain viable for prolonged periods of time in powdered infant formula, and the presence of nitrogen enhances survival. Practical Application: Our goal in this work was to study the survival ofS.Typhi andS. dysenteriaein dehydrated storage conditions in infant formula. This interest is partially generated by the possibility of using these 2 microorganisms to deliberately contaminate the food supply. The outcome of this study will help us to have a better idea how to respond and react to the risk of deliberate food contamination. JF - Journal of Food Science AU - Day, James B AU - Sharma, Devang AU - Siddique, Nusrat AU - Hao, Yun-Yun D AU - Strain, Errol A AU - Blodgett, Robert J AU - Al-Khaldi, Sufian F AD - Authors Day, Sharma, Siddique, Hao, and Al-Khaldi are with Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, U.S.A. Author Sharma is also with Fischell Dept. of Bioengineering, A. James Clark School of Engineering and author Siddique is also with Dept. of Cell Biology and Molecular Genetics, School of Life Science, Univ. of Maryland, College Park, MD 20740-3835, U.S.A. Authors Strain and Blodgett are with Division of Public Health and Biostatistics, Office of Food Defense, Communication, and Emergency Response, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD 20740-3835, U.S.A. Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - M324 EP - M328 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 76 IS - 6 SN - 0022-1147, 0022-1147 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - infant formulas KW - Infant formulas KW - Contamination KW - Food KW - Anadromous species KW - Survival KW - Atmosphere KW - Shigella dysenteriae KW - Disease transmission KW - Atmospheric conditions KW - Mortality KW - Food supply KW - Salmonella typhi KW - Pathogens KW - Food contamination KW - Storage conditions KW - Microorganisms KW - Neonates KW - survival KW - Nitrogen KW - Infants KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899136702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Survival+of+Salmonella+Typhi+and+Shigella+dysenteriae+in+Dehydrated+Infant+Formula&rft.au=Day%2C+James+B%3BSharma%2C+Devang%3BSiddique%2C+Nusrat%3BHao%2C+Yun-Yun+D%3BStrain%2C+Errol+A%3BBlodgett%2C+Robert+J%3BAl-Khaldi%2C+Sufian+F&rft.aulast=Day&rft.aufirst=James&rft.date=2011-08-01&rft.volume=76&rft.issue=6&rft.spage=M324&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2011.02268.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Document feature - figure 2 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Contamination; Storage conditions; Anadromous species; Microorganisms; Survival; Pathogens; Disease transmission; Infant formulas; Food; Neonates; Food contamination; Atmosphere; Atmospheric conditions; Infants; Nitrogen; infant formulas; Mortality; Food supply; survival; Salmonella typhi; Shigella dysenteriae DO - http://dx.doi.org/10.1111/j.1750-3841.2011.02268.x ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1-BROMOPROPANE (CAS NO. 106-94-5) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) AN - 893817568; 21921963 AB - 1-Bromopropane is used for degreasing and as a solvent for adhesive resins. We studied 1-bromopropane to determine if it caused cancer in rats or mice. We exposed groups of 50 male and female rats and mice to air containing 1-bromopropane six hours per day, five days a week for two years. Rats were exposed to concentrations of 125, 250, or 500 parts per million (ppm) of 1-bromopropane in air, and mice were exposed to concentrations of 62.5, 125, or 250 ppm. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers as the treated control groups six hours per day. Tissues from more than 40 sites were examined for every animal. A few rare tumors of large intestine were seen in exposed male and female rats, and a variety of skin tumors were seen in exposed male rats and to a lesser extent in exposed female rats. Male rats also had slightly increased incidences of malignant mesotheliomas and of pancreatic islet adenoma and carcinoma. Female mice had markedly increased incidences of adenomas and carcinomas of the lung. Male and female rats and mice exposed to 1-bromopropane had hyperplasia of the nose. Some exposed male and female rats also had inflammation of the larynx, and most exposed male and female mice had regeneration of bronchioles of the lung. We conclude that 1-bromopropane caused cancer of the large intestine in male and female rats and of the lung in female mice. 1-Bromopropane caused tumors of the skin in male rats and possibly in female rats also. Malignant mesotheliomas and pancreatic islet adenomas and carcinomas in male rats also were possibly associated with exposure to 1-bromopropane. Rats and mice of both sexes exposed to 1-bromopropane had hyperplasia and inflammation of the nose and other effects in the upper respiratory system (inflammation of the larynx in rats, regeneration of lung tissue in mice). JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 EP - 190 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Hydrocarbons, Brominated KW - Solvents KW - 1-bromopropane KW - Studies KW - Rodents KW - Carcinogens KW - Toxicology KW - Animals KW - Intestinal Neoplasms -- pathology KW - Hydrocarbons, Brominated -- administration & dosage KW - Skin Neoplasms -- pathology KW - Mice KW - Respiratory System -- pathology KW - Neoplasms, Experimental -- pathology KW - Hydrocarbons, Brominated -- toxicity KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Skin Neoplasms -- chemically induced KW - Solvents -- administration & dosage KW - Carcinogenicity Tests KW - Adenoma -- pathology KW - Administration, Inhalation KW - Species Specificity KW - Female KW - Male KW - Respiratory System -- drug effects KW - Solvents -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Adenoma -- chemically induced KW - Intestinal Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893817568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+1-BROMOPROPANE+%28CAS+NO.+106-94-5%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=564&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 893811421 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=564&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 893811413 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=564&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PULEGONE (CAS NO. 89-82-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 893811406; 21921962 AB - Pulegone is a component of essential oils of plants including pennyroyal, mint, and peppermint. It is used primarily as a mint flavoring in foods. We studied the effects of pulegone on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited pulegone dissolved in corn oil through a tube directly into the stomach to groups of 50 male and female rats and mice for up to two years. Male rats received 18.75, 37.5, or 75 milligrams of pulegone per kilogram of body weight five times per week; female rats and male and female mice received 37.5, 75, or 150 mg/kg five days per week. Control animals received corn oil with no chemical added by the same method. After 60, weeks many of the male rats receiving 75 mg/kg and female rats receiving 150 mg/kg had died, so the surviving animals from those groups received undosed corn oil for the duration of the study. At the end of the study, tissues from more than 40 sites were examined for every animal. A unique kidney lesion, hyaline glomerulopathy, was seen in all dosed groups of male and female mice and in the groups of rats receiving the highest doses of pulegone. Female rats receiving pulegone had increased incidences of urinary bladder tumors. Male and female mice had increased incidences of benign and malignant tumors of the liver, and female mice also had a small increase in rare bone lesions (osteoma or osteosarcoma). We conclude that pulegone caused cancer of the urinary bladder in female rats and cancer of the liver in male and female mice. Neoplasms of the bone in female mice were also possibly associated with administration of pulegone. There were no increases in cancers in male rats receiving pulegone. Pulegone also caused an unusual kidney lesion, hyaline glomerulopathy, in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 EP - 201 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Food Additives KW - Monoterpenes KW - pulegone KW - Rodents KW - Toxicology KW - Oils & fats KW - Studies KW - Animals KW - Kidney Diseases -- pathology KW - Administration, Cutaneous KW - Urinary Bladder Neoplasms -- pathology KW - Carcinogens -- administration & dosage KW - Monoterpenes -- classification KW - Food Additives -- administration & dosage KW - Monoterpenes -- administration & dosage KW - Mice KW - Bone Neoplasms -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Liver Neoplasms -- pathology KW - Carcinogens -- classification KW - Carcinogenicity Tests KW - Kidney Glomerulus -- drug effects KW - Food Additives -- classification KW - Kidney Glomerulus -- pathology KW - Male KW - Female KW - Kidney Diseases -- chemically induced KW - Monoterpenes -- toxicity KW - Bone Neoplasms -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Food Additives -- toxicity KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+PULEGONE+%28CAS+NO.+89-82-7%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=563&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Document feature - Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 893811399 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=563&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF BIS(2-CHLOROETHOXY)METHANE (CAS No. 111-91-1) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES) AN - 893811392; 21921961 AB - Bis(2-chloroethoxy)methane is used as a solvent and to make fungicides and polymers. We studied the effects of bis(2-chloroethoxy)methane on male and female rats and mice to identify potential toxic or cancer-related hazards. We painted solutions containing bis(2-chloroethoxy)methane in ethanol on the backs of male and female rats and mice. Groups of 50 male and female rats received 75, 150, or 300 milligrams of bis(2-chloroethoxy)methane per kilogram of body weight 5 days per week for 2 years; similar groups of male mice received 150, 300, or 600 mg/kg and female mice received 100, 200, or 400 mg/kg. Groups of animals receiving ethanol alone served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. The only effects observed in male and female rats were degeneration of the olfactory epithelium of the nose, and some instances of stomach inflammation or ulcer were observed in males. Male and female mice receiving bis(2-chloroethoxy)methane had increased rates of some alterations of heart tissue that were termed cardiomyopathy. Male mice also had inflammation of the skin and stomach ulcers. We conclude that exposure to bis(2-chloroethoxy)methane did not cause cancer in male or female rats or mice. Exposure to bis(2-chloroethoxy)methane caused some non-cancerous lesions of the nose in rats and the heart in mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 EP - 203 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Ethyl Ethers KW - Solvents KW - bis(2-chloroethoxy)methane KW - Studies KW - Methane KW - Carcinogens KW - Rodents KW - Animals KW - Administration, Cutaneous KW - Ethyl Ethers -- administration & dosage KW - Heart Diseases -- chemically induced KW - Longevity -- drug effects KW - Olfactory Mucosa -- pathology KW - Mice KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Cardiomyopathies -- pathology KW - Nose -- pathology KW - Solvents -- administration & dosage KW - Carcinogenicity Tests KW - Cardiomyopathies -- chemically induced KW - Nose -- drug effects KW - Female KW - Heart Diseases -- pathology KW - Male KW - Olfactory Mucosa -- drug effects KW - Solvents -- toxicity KW - Ethyl Ethers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BIS%282-CHLOROETHOXY%29METHANE+%28CAS+No.+111-91-1%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28DERMAL+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=536&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Document feature - Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 893811386 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=563&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 893811380 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=536&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 893811374 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893811374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-08-01&rft.volume=&rft.issue=536&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2011 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Forces and Moments on the Knee During Kneeling and Squatting AN - 893282981; 15669884 AB - Euler angle decomposition and inverse dynamics were used to determine the knee angles and net forces and moments applied to the tibia during kneeling and squatting with and without kneepads for 10 subjects in four postures: squatting (Squat), kneeling on the right knee (One Knee), bilateral kneeling near full flexion (Near Full) and bilateral kneeling near 90 degree flexion (Near 90). Kneepads affected the knee flexion (p = .002), medial forces (p = .035), and internal rotation moments (p = .006). Squat created loading conditions that had higher varus (p < .001) and resultant moments (p = .027) than kneeling. One Knee resulted in the highest force magnitudes and net moments (p < .001) of the kneeling postures. Thigh-calf and heel-gluteus contact forces decreased the flexion moment on average by 48% during Squat and Near Full. JF - Journal of Applied Biomechanics AU - Pollard, J P AU - Porter, W L AU - Redfern AD - National Institute for Occupational Safety and Health, Office of Mine Safety and Health Research, Pittsburgh, PA, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 233 EP - 241 VL - 27 IS - 3 SN - 1065-8483, 1065-8483 KW - Physical Education Index KW - Knees KW - Posture KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893282981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Biomechanics&rft.atitle=Forces+and+Moments+on+the+Knee+During+Kneeling+and+Squatting&rft.au=Pollard%2C+J+P%3BPorter%2C+W+L%3BRedfern&rft.aulast=Pollard&rft.aufirst=J&rft.date=2011-08-01&rft.volume=27&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Biomechanics&rft.issn=10658483&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Knees; Posture; Biomechanics ER - TY - JOUR T1 - Sleep Duration and Biomarkers of Metabolic Function Among Police Officers AN - 893269009; 15630947 AB - Objective: To investigate associations between sleep duration and biomarkers of metabolic function among police officers. Methods: Metabolic markers were measured using standardized methods and sleep duration was assessed from questionnaire data. Mean levels of leptin and adiponectin were assessed across five levels of sleep duration using ANCOVA and linear regression models. Results: Police officers (n = 443) who reported an average of less than 5 hours and at least 8 hours of sleep had higher levels of leptin compared to those who reported an average of 5 to 7 hours of sleep. These associations were stronger and statistically significant among women, officers with BMI of 24.9 kg/m super(2) or less and smaller abdominal height (< 20 cm), and officers who primarily worked on the day shift. Conclusion: Short and long sleep duration were associated with higher leptin levels and may have implications for obesity-related conditions. JF - Journal of Occupational and Environmental Medicine AU - Charles, LE AU - Gu, J K AU - Andrew, ME AU - Violanti, J M AU - Fekedulegn, D AU - Burchfiel, C M AD - National Institute for Occupational Safety and Health, HELD/BEB, MS L-4050, 1095 Willowdale, Rd, Morgantown, WV 26505, USA, lcharles@cdc.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 831 EP - 837 VL - 53 IS - 8 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Bioindicators KW - police KW - body mass KW - Standards KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893269009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Sleep+Duration+and+Biomarkers+of+Metabolic+Function+Among+Police+Officers&rft.au=Charles%2C+LE%3BGu%2C+J+K%3BAndrew%2C+ME%3BViolanti%2C+J+M%3BFekedulegn%2C+D%3BBurchfiel%2C+C+M&rft.aulast=Charles&rft.aufirst=LE&rft.date=2011-08-01&rft.volume=53&rft.issue=8&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821f5ece LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; police; body mass; Standards DO - http://dx.doi.org/10.1097/JOM.0b013e31821f5ece ER - TY - JOUR T1 - Effects of dietary phenolics and botanical extracts on hepatotoxicity-related endpoints in human and rat hepatoma cells and statistical models for prediction of hepatotoxicity AN - 888097176; 15092479 AB - Toxicity assessment of botanical materials is difficult because they are typically complex mixtures of phytochemicals. In the present study, 16 phenolics were tested in both human (HepG2/C3A) and rat (MH1C1) hepatoma cells using a battery of eight toxicity endpoints. Cluster analysis was used to group the phenolics into four clusters for each cell type. Comparison of overall and individual liver activity of phenolics on both human and rat hepatoma cell lines showed significant differences for some endpoints. However, the cluster membership was similar across both cell types with the majority of phenolics clustering with the solvent control group (cluster 1). Each cell type produced a cluster of compounds with reported in vivo liver toxicity (cluster 2). Five herbal extracts were prepared and then tested as above. Using the cluster model developed with the phenolics, in the HepG2/C3A cells green tea was assigned to cluster 2 and the remaining four extracts to cluster 1. In the MH1C1 cells, green tea and thyme were assigned to cluster 2, cinnamon to cluster 4, and juniper berry and peppermint to cluster 1. The data suggest that this in vitro model may be useful for identifying hepatotoxic phenolics and botanical preparations rich in phenolics. JF - Food and Chemical Toxicology AU - Liu, Yitong AU - Flynn, Thomas J AU - Ferguson, Martine S AU - Hoagland, Erica M AU - Yu, Liangli AD - Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742-7640, United States, thomas.flynn@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1820 EP - 1827 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 49 IS - 8 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Hepatotoxicity KW - Dietary phenolics KW - Botanical extracts KW - Cluster analysis KW - Fruits KW - Data processing KW - Mathematical models KW - cinnamon KW - green tea KW - Thymus KW - Solvents KW - Statistical analysis KW - Toxicity KW - hepatotoxicity KW - Hepatoma KW - Liver KW - phenolic compounds KW - Mentha piperita KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888097176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Effects+of+dietary+phenolics+and+botanical+extracts+on+hepatotoxicity-related+endpoints+in+human+and+rat+hepatoma+cells+and+statistical+models+for+prediction+of+hepatotoxicity&rft.au=Liu%2C+Yitong%3BFlynn%2C+Thomas+J%3BFerguson%2C+Martine+S%3BHoagland%2C+Erica+M%3BYu%2C+Liangli&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2011-08-01&rft.volume=49&rft.issue=8&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2011.04.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Fruits; Hepatoma; Mathematical models; Data processing; cinnamon; green tea; Statistical analysis; Solvents; Liver; phenolic compounds; Toxicity; hepatotoxicity; Thymus; Mentha piperita DO - http://dx.doi.org/10.1016/j.fct.2011.04.034 ER - TY - JOUR T1 - Pittsburgh Section supports new student subsection AN - 885963650 AB - Mining professionals from local coal companies, equipment manufacturers and the SME Pittsburgh Section observed the students' presentations, which were informative, progressive and helpful to the mining operations. JF - Mining Engineering AU - Bealko, Susan, NIOSH Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 56 CY - Littleton PB - Society for Mining, Metallurgy, and Exploration, Inc. VL - 63 IS - 8 SN - 00265187 KW - Engineering KW - Coal mining KW - Colleges & universities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885963650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asciencejournals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Mining+Engineering&rft.atitle=Pittsburgh+Section+supports+new+student+subsection&rft.au=Bealko%2C+Susan%2C+NIOSH&rft.aulast=Bealko&rft.aufirst=Susan&rft.date=2011-08-01&rft.volume=63&rft.issue=8&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Pennsylvania State University N1 - Copyright - Copyright Society for Mining, Metallurgy, and Exploration, Inc. Aug 2011 N1 - Last updated - 2016-10-08 N1 - CODEN - MIENAB ER - TY - JOUR T1 - Young Leaders Committee issues call for 2012 applicants AN - 885962633 AB - Ine objective of the YLC program is twofold: to target and recognize the young leaders of SME and increase the involvement of these professionals within the society and to use the YLC as a tool to add value to SME by offering professional development programs and services for the society as a whole. JF - Mining Engineering AU - Martikainen, Anu, NIOSH Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 63 CY - Littleton PB - Society for Mining, Metallurgy, and Exploration, Inc. VL - 63 IS - 8 SN - 00265187 KW - Engineering KW - Leadership KW - Associations KW - Meetings KW - Small & medium sized enterprises-SME UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885962633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asciencejournals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=Young+Leaders+Committee+issues+call+for+2012+applicants&rft.au=Martikainen%2C+Anu%2C+NIOSH&rft.aulast=Martikainen&rft.aufirst=Anu&rft.date=2011-08-01&rft.volume=63&rft.issue=8&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright Society for Mining, Metallurgy, and Exploration, Inc. Aug 2011 N1 - Last updated - 2016-10-08 N1 - CODEN - MIENAB ER - TY - JOUR T1 - Effective hepatitis A virus inactivation during low-heat dehydration of contaminated green onions AN - 883024383; 14892697 AB - Preserving fruits and vegetables by dehydration is common; however, information is limited concerning viral survival on the produce during the process. This work demonstrated the effects of low heat dehydration on inactivating hepatitis A virus (HAV) on contaminated green onions. Inoculated and uninoculated onion samples were dehydrated at target temperatures of 45-65 degree C for 20h. HAV from artificially contaminated onions (fresh or dehydrated) was eluted by shaking at 145 rpm at 20 degree C for 20 min with 3% beef extract, pH 8, and followed by 0.2 mu M-membrane filtration before plaque assay and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analysis. Dilutions of the filtrates were made for obtaining countable plaques on FRhK-4 cell monolayers in 6-well plates, and also for eliminating inhibitors in qRT-PCR. Average water activity of the onions after 20 h-dehydration was 0.227, regardless of temperature used (47.9 degree C or 65.1 degree C). Eight dehydration trials resulted in a linear relationship between HAV inactivation and dehydration temperature, with HAV log reduction = 0.1372x( degree C) - 5.5572, r super(2) = 0.88. Therefore, the 20 h-heating at 47.8, 55.1, and 62.4 degree C reduced infectious HAV in onions by 1, 2, and 3 logs respectively, the Z value being 7.3 degree C. It was concluded that low heat dehydration using 62.5 degree C or above could effectively inactivate HAV on contaminated onions by >3 logs. JF - Food Microbiology AU - Laird, David T AU - Sun, Yan AU - Reineke, Karl F AU - Carol Shieh, Y AD - US Food and Drug Administration, National Center for Food Safety and Technology, 6502 S. Archer Road, Summit-Argo, IL 60501, USA, carol.shieh@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 998 EP - 1002 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 5 SN - 0740-0020, 0740-0020 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Hepatitis A virus KW - Thermal inactivation KW - Low heat dehydration KW - Green onion KW - Temperature effects KW - Fruits KW - Vegetables KW - Water activity KW - Survival KW - Water temperature KW - Filtration KW - Beef KW - Heat KW - Allium cepa KW - Plaque assay KW - Plaques KW - pH effects KW - Dehydration KW - V 22420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883024383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Effective+hepatitis+A+virus+inactivation+during+low-heat+dehydration+of+contaminated+green+onions&rft.au=Laird%2C+David+T%3BSun%2C+Yan%3BReineke%2C+Karl+F%3BCarol+Shieh%2C+Y&rft.aulast=Laird&rft.aufirst=David&rft.date=2011-08-01&rft.volume=28&rft.issue=5&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.01.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Fruits; Vegetables; Water activity; Survival; Water temperature; Filtration; Heat; Beef; Plaque assay; Plaques; pH effects; Dehydration; Hepatitis A virus; Allium cepa DO - http://dx.doi.org/10.1016/j.fm.2011.01.011 ER - TY - JOUR T1 - Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice. AN - 880996663; 21501981 AB - Prenatal exposure to perfluorooctanoic acid (PFOA), a ubiquitous industrial surfactant, has been reported to delay mammary gland development in female mouse offspring (F1) and the treated lactating dam (P0) after gestational treatments at 3 and 5 mg PFOA/kg/day. We investigated the consequences of gestational and chronic PFOA exposure on F1 lactational function and subsequent development of F2 offspring. We treated P0 dams with 0, 1, or 5 mg PFOA/kg/day on gestation days 1-17. In addition, a second group of P0 dams treated with 0 or 1 mg/kg/day during gestation and their F1 and F2 offspring received continuous PFOA exposure (5 ppb) in drinking water. Resulting adult F1 females were bred to generate F2 offspring, whose development was monitored over postnatal days (PNDs) 1-63. F1 gland function was assessed on PND10 by timed-lactation experiments. Mammary tissue was isolated from P0, F1, and F2 females throughout the study and histologically assessed for age-appropriate development. PFOA-exposed F1 dams exhibited diminished lactational morphology, although F1 maternal behavior and F2 offspring body weights were not significantly affected by P0 treatment. In addition to reduced gland development in F1 females under all exposures, F2 females with chronic low-dose drinking-water exposures exhibited visibly slowed mammary gland differentiation from weaning onward. F2 females derived from 5 mg/kg PFOA-treated P0 dams displayed gland morphology similar to F2 chronic water exposure groups on PNDs 22-63. Gestational PFOA exposure induced delays in mammary gland development and/or lactational differentiation across three generations. Chronic, low-dose PFOA exposure in drinking water was also sufficient to alter mammary morphological development in mice, at concentrations approximating those found in contaminated human water supplies. JF - Environmental health perspectives AU - White, Sally S AU - Stanko, Jason P AU - Kato, Kayoko AU - Calafat, Antonia M AU - Hines, Erin P AU - Fenton, Suzanne E AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1070 EP - 1076 VL - 119 IS - 8 KW - Caprylates KW - 0 KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - Lactation -- drug effects KW - Animals KW - Gestational Age KW - Mice KW - Female KW - Prenatal Exposure Delayed Effects KW - Pregnancy KW - Mammary Glands, Animal -- drug effects KW - Fluorocarbons -- toxicity KW - Mammary Glands, Animal -- growth & development KW - Caprylates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880996663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Gestational+and+chronic+low-dose+PFOA+exposures+and+mammary+gland+growth+and+differentiation+in+three+generations+of+CD-1+mice.&rft.au=White%2C+Sally+S%3BStanko%2C+Jason+P%3BKato%2C+Kayoko%3BCalafat%2C+Antonia+M%3BHines%2C+Erin+P%3BFenton%2C+Suzanne+E&rft.aulast=White&rft.aufirst=Sally&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002741 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2002 May;67(1):63-74 [11961217] Toxicol Sci. 2010 May;115(1):214-24 [20118188] Toxicol Sci. 2004 Apr;78(2):248-57 [14718648] J Occup Health. 2004 Mar;46(2):141-7 [15090689] Toxicol Appl Pharmacol. 2004 Jul 15;198(2):231-41 [15236955] Arch Environ Contam Toxicol. 1977;6(2-3):279-92 [409355] Environ Sci Technol. 2004 Oct 15;38(20):5379-85 [15543740] Chem Biol Interact. 2005 Aug 15;155(3):165-80 [16098497] Environ Sci Technol. 2006 Jan 1;40(1):32-44 [16433330] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] J Occup Environ Med. 2006 Aug;48(8):759-70 [16902368] Toxicol Sci. 2007 Feb;95(2):462-73 [17098816] Toxicol Sci. 2007 Mar;96(1):133-44 [17132714] Chemosphere. 2007 May;68(1):105-11 [17267015] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Toxicol Sci. 2009 Feb;107(2):331-41 [19005225] Reprod Toxicol. 2009 Jun;27(3-4):299-306 [19013232] Reprod Toxicol. 2009 Jun;27(3-4):289-98 [19095057] Environ Sci Technol. 2002 Apr 1;36(7):146A-152A [11999053] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002741 ER - TY - JOUR T1 - Acute pesticide illnesses associated with off-target pesticide drift from agricultural applications: 11 States, 1998-2006. AN - 880995843; 21642048 AB - Pesticides are widely used in agriculture, and off-target pesticide drift exposes workers and the public to harmful chemicals. We estimated the incidence of acute illnesses from pesticide drift from outdoor agricultural applications and characterized drift exposure and illnesses. Data were obtained from the National Institute for Occupational Safety and Health's Sentinel Event Notification System for Occupational Risks-Pesticides program and the California Department of Pesticide Regulation. Drift included off-target movement of pesticide spray, volatiles, and contaminated dust. Acute illness cases were characterized by demographics, pesticide and application variables, health effects, and contributing factors. From 1998 through 2006, we identified 2,945 cases associated with agricultural pesticide drift from 11 states. Our findings indicate that 47% were exposed at work, 92% experienced low-severity illness, and 14% were children (< 15 years). The annual incidence ranged from 1.39 to 5.32 per million persons over the 9-year period. The overall incidence (in million person-years) was 114.3 for agricultural workers, 0.79 for other workers, 1.56 for nonoccupational cases, and 42.2 for residents in five agriculture-intensive counties in California. Soil applications with fumigants were responsible for the largest percentage (45%) of cases. Aerial applications accounted for 24% of cases. Common factors contributing to drift cases included weather conditions, improper seal of the fumigation site, and applicator carelessness near nontarget areas. Agricultural workers and residents in agricultural regions had the highest rate of pesticide poisoning from drift exposure, and soil fumigations were a major hazard, causing large drift incidents. Our findings highlight areas where interventions to reduce off-target drift could be focused. JF - Environmental health perspectives AU - Lee, Soo-Jeong AU - Mehler, Louise AU - Beckman, John AU - Diebolt-Brown, Brienne AU - Prado, Joanne AU - Lackovic, Michelle AU - Waltz, Justin AU - Mulay, Prakash AU - Schwartz, Abby AU - Mitchell, Yvette AU - Moraga-McHaley, Stephanie AU - Gergely, Rita AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1162 EP - 1169 VL - 119 IS - 8 KW - Pesticides KW - 0 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Agriculture -- statistics & numerical data KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880995843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Acute+pesticide+illnesses+associated+with+off-target+pesticide+drift+from+agricultural+applications%3A+11+States%2C+1998-2006.&rft.au=Lee%2C+Soo-Jeong%3BMehler%2C+Louise%3BBeckman%2C+John%3BDiebolt-Brown%2C+Brienne%3BPrado%2C+Joanne%3BLackovic%2C+Michelle%3BWaltz%2C+Justin%3BMulay%2C+Prakash%3BSchwartz%2C+Abby%3BMitchell%2C+Yvette%3BMoraga-McHaley%2C+Stephanie%3BGergely%2C+Rita%3BCalvert%2C+Geoffrey+M&rft.aulast=Lee&rft.aufirst=Soo-Jeong&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1162&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002843 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Agromedicine. 2005;10(4):27-42 [16702121] J Expo Sci Environ Epidemiol. 2006 Sep;16(5):387-96 [16249796] MMWR Morb Mortal Wkly Rep. 2008 Jan 4;56(51-52):1343-5 [18172421] Am J Ind Med. 2008 Dec;51(12):883-98 [18666136] JAMA. 2005 Jul 27;294(4):455-65 [16046652] J Agromedicine. 2010 Jan;15(1):24-37 [20390729] Am J Ind Med. 2004 Jan;45(1):14-23 [14691965] Environ Health Perspect. 2004 Mar;112(3):382-7 [14998757] MMWR Morb Mortal Wkly Rep. 2004 Aug 20;53(32):740-2 [15318159] Environ Sci Technol. 2009 Dec 1;43(23):8767-74 [19943644] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002843 ER - TY - JOUR T1 - Chemical genomics profiling of environmental chemical modulation of human nuclear receptors. AN - 880995824; 21543282 AB - The large and increasing number of chemicals released into the environment demands more efficient and cost-effective approaches for assessing environmental chemical toxicity. The U.S. Tox21 program has responded to this challenge by proposing alternative strategies for toxicity testing, among which the quantitative high-throughput screening (qHTS) paradigm has been adopted as the primary tool for generating data from screening large chemical libraries using a wide spectrum of assays. The goal of this study was to develop methods to evaluate the data generated from these assays to guide future assay selection and prioritization for the Tox21 program. We examined the data from the Tox21 pilot-phase collection of approximately 3,000 environmental chemicals profiled in qHTS format against a panel of 10 human nuclear receptors (AR, ERα, FXR, GR, LXRβ, PPARγ, PPARδ, RXRα, TRβ, and VDR) for reproducibility, concordance of biological activity profiles with sequence homology of the receptor ligand binding domains, and structure-activity relationships. We determined the assays to be appropriate in terms of biological relevance. We found better concordance for replicate compounds for the agonist-mode than for the antagonist-mode assays, likely due to interference of cytotoxicity in the latter assays. This exercise also enabled us to formulate data-driven strategies for discriminating true signals from artifacts, and to prioritize assays based on data quality. The results demonstrate the feasibility of qHTS to identify the potential for environmentally relevant chemicals to interact with key toxicity pathways related to human disease induction. JF - Environmental health perspectives AU - Huang, Ruili AU - Xia, Menghang AU - Cho, Ming-Hsuang AU - Sakamuru, Srilatha AU - Shinn, Paul AU - Houck, Keith A AU - Dix, David J AU - Judson, Richard S AU - Witt, Kristine L AU - Kavlock, Robert J AU - Tice, Raymond R AU - Austin, Christopher P AD - National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA. huangru@mail.nih.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1142 EP - 1148 VL - 119 IS - 8 KW - Environmental Pollutants KW - 0 KW - Estrogen Receptor alpha KW - Liver X Receptors KW - Orphan Nuclear Receptors KW - PPAR gamma KW - Peroxisome Proliferator-Activated Receptors KW - Receptors, Androgen KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Thrombin KW - Retinoid X Receptor alpha KW - Fragile X Mental Retardation Protein KW - 139135-51-6 KW - Index Medicus KW - Receptors, Thrombin -- metabolism KW - Orphan Nuclear Receptors -- metabolism KW - PPAR gamma -- antagonists & inhibitors KW - Peroxisome Proliferator-Activated Receptors -- antagonists & inhibitors KW - Humans KW - Retinoid X Receptor alpha -- antagonists & inhibitors KW - Retinoid X Receptor alpha -- agonists KW - Receptors, Thrombin -- agonists KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Estrogen Receptor alpha -- metabolism KW - Retinoid X Receptor alpha -- metabolism KW - Peroxisome Proliferator-Activated Receptors -- agonists KW - Receptors, Thrombin -- antagonists & inhibitors KW - Receptors, Androgen -- metabolism KW - Orphan Nuclear Receptors -- agonists KW - Orphan Nuclear Receptors -- antagonists & inhibitors KW - PPAR gamma -- metabolism KW - Cell Line KW - Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors KW - Receptors, Cytoplasmic and Nuclear -- agonists KW - Environmental Pollutants -- toxicity KW - Receptors, Cytoplasmic and Nuclear -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880995824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Chemical+genomics+profiling+of+environmental+chemical+modulation+of+human+nuclear+receptors.&rft.au=Huang%2C+Ruili%3BXia%2C+Menghang%3BCho%2C+Ming-Hsuang%3BSakamuru%2C+Srilatha%3BShinn%2C+Paul%3BHouck%2C+Keith+A%3BDix%2C+David+J%3BJudson%2C+Richard+S%3BWitt%2C+Kristine+L%3BKavlock%2C+Robert+J%3BTice%2C+Raymond+R%3BAustin%2C+Christopher+P&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2011-08-01&rft.volume=119&rft.issue=8&rft.spage=1142&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002952 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-28 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2009 Nov;112(1):153-63 [19502547] Toxicol Sci. 2009 Dec;112(2):385-93 [19805409] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Invest New Drugs. 1999;17(3):285-311 [10665480] Nature. 2000 May 25;405(6785):421-4 [10839530] Gen Physiol Biophys. 2000 Mar;19(1):73-84 [10930140] Hum Reprod Update. 2001 May-Jun;7(3):248-64 [11392371] Mol Endocrinol. 2003 Jun;17(6):985-93 [12690094] J Appl Toxicol. 2004 Jan-Feb;24(1):1-4 [14745840] Genome Res. 2004 Apr;14(4):580-90 [15059999] Toxicol Appl Pharmacol. 1988 Mar 30;93(1):72-80 [3354002] Toxicol Appl Pharmacol. 1994 Jun;126(2):276-85 [8209380] Environ Health Perspect. 1996 Oct;104(10):1084-9 [8930550] Nature. 1997 Oct 16;389(6652):753-8 [9338790] J Mol Endocrinol. 1997 Dec;19(3):207-26 [9460643] Cell. 1998 Dec 23;95(7):927-37 [9875847] Nat Rev Drug Discov. 2004 Nov;3(11):950-64 [15520817] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] Neural Netw. 2006 Jul-Aug;19(6-7):723-33 [16774731] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] FEBS Lett. 2008 Jan 9;582(1):2-9 [18023286] Science. 2008 Feb 15;319(5865):906-7 [18276874] Environ Health Perspect. 2008 Mar;116(3):284-91 [18335092] Chem Res Toxicol. 2008 Mar;21(3):659-67 [18281954] J Med Chem. 2008 Apr 24;51(8):2363-71 [18363325] Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2412-7 [19196967] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7233-8 [19363158] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Clin Breast Cancer. 2009 Jun;9 Suppl 1:S6-S17 [19561006] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002952 ER - TY - JOUR T1 - Voluntary exercise protects hippocampal neurons from trimethyltin injury: possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. AN - 878030607; 21435392 AB - In the periphery, exercise induces interleukin (IL)-6 to downregulate tumor necrosis factor (TNF), elevate interleukin-1 receptor antagonist (IL-1RA), decreasing inflammation. Exercise also offers neuroprotection and facilitates brain repair. IL-6 production in the hippocampus following exercise suggests the potential of a similar protective role as in the periphery to down-regulate TNFα and inflammation. Using a chemical-induced model of hippocampal dentate granule cell death (trimethyltin, TMT 2.4 mg/kg, ip) dependent upon TNF receptor signaling, we demonstrate neuroprotection in mice with 2 weeks access to running wheel. Exercise attenuated neuronal death and diminished elevations in TNFα, TNF receptor 1, myeloid differentiation primary response gene (MyD) 88, transforming growth factor β, chemokine (C-C motif) ligand 2 (CCL2), and CCL3. Elevated mRNA levels for IL-1α, IL-1RA, occurred with injury and protection. mRNA and protein levels of IL-6 and neuronal expression of IL-6 receptor α, were elevated with injury and protection. Microarray pathway analysis supported an up-regulation of TNFα cell death signaling pathways with TMT and inhibition by exercise. IL-6 pathway recruitment occurred in both conditions. IL-6 downstream signal events differed in the level of STAT3 activation. Exercise did not increase mRNA levels of brain derived neurotrophic factor, nerve growth factor, or glial derived neurotrophic factor. In IL-6 deficient mice, exercise did not attenuate TMT-induced tremor and a diminished level of neuroprotection was observed. These data suggest a contributory role for IL-6 induced by exercise for neuroprotection in the CNS similar to that seen in the periphery. Published by Elsevier Inc. JF - Brain, behavior, and immunity AU - Funk, Jason A AU - Gohlke, Julia AU - Kraft, Andrew D AU - McPherson, Christopher A AU - Collins, Jennifer B AU - Jean Harry, G AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, United States. Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1063 EP - 1077 VL - 25 IS - 6 KW - Chemokines KW - 0 KW - Interleukin-6 KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Nerve Tissue Proteins KW - Neurotoxins KW - RNA, Messenger KW - Receptors, Tumor Necrosis Factor KW - Trimethyltin Compounds KW - Tumor Necrosis Factor-alpha KW - trimethyltin hydroxide KW - 56-24-6 KW - Index Medicus KW - Specific Pathogen-Free Organisms KW - Animals KW - Chemokines -- genetics KW - Random Allocation KW - Chemokines -- biosynthesis KW - Tumor Necrosis Factor-alpha -- physiology KW - Mice KW - Nerve Tissue Proteins -- biosynthesis KW - RNA, Messenger -- genetics KW - Nerve Tissue Proteins -- genetics KW - Tremor -- chemically induced KW - RNA, Messenger -- biosynthesis KW - Mice, Knockout KW - Epilepsy, Tonic-Clonic -- chemically induced KW - Myeloid Differentiation Factor 88 -- biosynthesis KW - Mice, Inbred C57BL KW - Myeloid Differentiation Factor 88 -- genetics KW - Up-Regulation KW - Models, Neurological KW - Radiation Chimera KW - Male KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Hippocampus -- metabolism KW - Interleukin-6 -- deficiency KW - Receptors, Tumor Necrosis Factor -- drug effects KW - Trimethyltin Compounds -- toxicity KW - Neurotoxins -- toxicity KW - Hippocampus -- drug effects KW - Neurons -- pathology KW - Interleukin-6 -- physiology KW - Receptors, Tumor Necrosis Factor -- biosynthesis KW - Physical Conditioning, Animal -- physiology KW - Receptors, Tumor Necrosis Factor -- physiology KW - Interleukin-6 -- genetics KW - Hippocampus -- pathology KW - Interleukin-6 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878030607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=Voluntary+exercise+protects+hippocampal+neurons+from+trimethyltin+injury%3A+possible+role+of+interleukin-6+to+modulate+tumor+necrosis+factor+receptor-mediated+neurotoxicity.&rft.au=Funk%2C+Jason+A%3BGohlke%2C+Julia%3BKraft%2C+Andrew+D%3BMcPherson%2C+Christopher+A%3BCollins%2C+Jennifer+B%3BJean+Harry%2C+G&rft.aulast=Funk&rft.aufirst=Jason&rft.date=2011-08-01&rft.volume=25&rft.issue=6&rft.spage=1063&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=1090-2139&rft_id=info:doi/10.1016%2Fj.bbi.2011.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-07 N1 - Date created - 2011-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Sci. 2009 Aug;110(4):424-36 [19602844] J Neuroendocrinol. 2010 Aug;22(8):872-88 [20406350] Acta Physiol (Oxf). 2011 Apr;201(4):475-82 [21083649] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Neurosci Lett. 2006 May 15;399(1-2):162-6 [16504399] Annu Rev Immunol. 2000;18:621-63 [10837071] Oncogene. 2000 May 15;19(21):2468-73 [10851045] J Physiol. 2000 Oct 1;528 Pt 1:157-63 [11018114] Glia. 2000 Dec;32(3):271-85 [11102968] Brain Res. 2001 Mar 30;896(1-2):86-95 [11277977] Int J Sports Med. 2001 May;22(4):261-7 [11414667] Mol Cell Biol. 2001 Aug;21(16):5299-305 [11463813] Brain Res. 2001 Sep 7;912(2):116-27 [11532427] Exp Neurol. 2002 May;175(1):152-60 [12009767] Toxicol Appl Pharmacol. 2002 May 1;180(3):205-18 [12009860] J Physiol. 2002 Aug 1;542(Pt 3):991-5 [12154196] Oncogene. 2002 Dec 12;21(57):8769-75 [12483530] Mol Cell Neurosci. 2002 Nov;21(3):379-92 [12498781] J Neurosci Res. 2003 Feb 15;71(4):583-90 [12548715] J Neuropathol Exp Neurol. 2003 Mar;62(3):315-28 [12638735] FASEB J. 2003 May;17(8):884-6 [12626436] Exp Neurol. 2003 Jun;181(2):130-48 [12781987] J Neurosci Res. 2003 Aug 15;73(4):526-36 [12898537] J Neurosci. 2004 May 5;24(18):4432-43 [15128857] Mol Pharmacol. 1992 Jul;42(1):44-56 [1635553] Blood. 1994 Jan 1;83(1):113-8 [8274730] J Exp Med. 1994 May 1;179(5):1529-37 [8163936] Science. 1994 Jun 3;264(5164):1415-21 [8197455] Infect Immun. 1995 Apr;63(4):1158-64 [7890366] Nature. 1995 Jul 13;376(6536):167-70 [7603567] Genomics. 1995 Sep 20;29(2):490-5 [8666399] Cell. 1996 Feb 9;84(3):331-4 [8608586] J Exp Med. 1996 Jun 1;183(6):2627-34 [8676083] EMBO J. 1996 Jul 15;15(14):3651-8 [8670868] Cell Tissue Res. 1997 Feb;287(3):447-58 [9023076] Immunity. 1997 Dec;7(6):837-47 [9430229] Glia. 1998 Feb;22(2):180-8 [9537838] J Neurochem. 1998 Oct;71(4):1577-87 [9751191] Biochem J. 1999 Jan 1;337 ( Pt 1):59-65 [9854025] J Neurosci. 1999 Jun 1;19(11):4305-13 [10341234] Genes Dev. 1999 Oct 1;13(19):2604-16 [10521404] Cancer Res. 2005 Feb 1;65(3):939-47 [15705894] Exp Brain Res. 2005 Sep;165(4):520-31 [15991029] J Neurosci. 2005 Sep 21;25(38):8680-5 [16177036] Gene Expr. 2006;13(1):41-52 [16572589] J Cell Biochem. 2006 May 15;98(2):243-50 [16453279] Ann N Y Acad Sci. 2006 Jul;1070:450-6 [16888208] Sci STKE. 2006 Oct 17;2006(357):re13 [17047224] Curr Neurovasc Res. 2006 Nov;3(4):263-71 [17109621] Brain Res. 2007 Feb 2;1131(1):17-28 [17161388] J Physiol Pharmacol. 2006 Nov;57 Suppl 10:43-51 [17242490] Nat Rev Neurosci. 2007 Mar;8(3):221-32 [17311007] Curr Opin Clin Nutr Metab Care. 2007 May;10(3):265-71 [17414493] Genes Dev. 2007 Jun 1;21(11):1396-408 [17510282] J Neurosci. 2007 Jun 20;27(25):6633-46 [17581950] Trends Cogn Sci. 2007 Aug;11(8):342-8 [17629545] Neuroendocrinology. 2007;86(1):26-37 [17595533] Cytokine Growth Factor Rev. 2007 Oct-Dec;18(5-6):511-8 [17683973] Prog Brain Res. 2007;163:355-70 [17765729] Trends Neurosci. 2007 Sep;30(9):464-72 [17765329] Curr Med Chem. 2007;14(24):2564-71 [17979709] Mol Cell Neurosci. 2008 Jan;37(1):110-8 [17933551] Neurochem Int. 2008 Mar-Apr;52(4-5):761-9 [17949856] Neurobiol Dis. 2008 Apr;30(1):121-9 [18258444] J Neuroinflammation. 2008;5:13 [18400101] J Neurochem. 2008 Jul;106(1):281-98 [18373618] Comment In: Brain Behav Immun. 2011 Aug;25(6):1061-2 [21640182] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbi.2011.03.012 ER - TY - JOUR T1 - A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid. AN - 876192561; 21620919 AB - Ingesting melamine adulterated milk products led to kidney stones in many infants in 2008. This differs from the renal failure caused by intratubular crystal formation after co-ingestion of melamine (MEL) and cyanuric acid (CYA) in adulterated pet foods in 2007. To better understand the potential risk of developing crystal nephropathy following co-ingestion of MEL and CYA, we fed 16 weanling pigs 0, 1, 3.3, 10, 33, or 100 mg/kg bw/day of each MEL and CYA, or 200 mg/kg bw/day of either compound individually for 7 days. Crystals were found in the renal medulla and cortex and urine sediments of all pigs fed both MEL and CYA each at 10 mg/kg bw/day (or greater). Crystals were also found in one of the two pigs fed 200 mg/kg bw/day MEL-only. In a 28 day study, 36 weanling pigs were fed 0, 1, or 3.3 mg/kg bw/day of MEL and CYA or 200 mg/kg bw/day MEL-only. Only one of the 3.3 mg/kg MEL and CYA pig kidneys contained crystals. The no-observed-adverse-effect level (NOAEL) for pigs fed MEL and CYA for 28 days was concluded to be 1.0 mg/kg bw/day corresponding to 25 mg/kg (ppm) MEL and 25 mg/kg (ppm) CYA in dry feed. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Stine, Cynthia B AU - Reimschuessel, Renate AU - Gieseker, Charles M AU - Evans, Eric R AU - Mayer, Tamara D AU - Hasbrouck, Nicholas R AU - Tall, Elizabeth AU - Boehmer, Jamie AU - Gamboa da Costa, Gonçalo AU - Ward, Jeffrey L AD - Center for Veterinary Medicine, USFDA, Laurel, MD 20708, USA. cynthia.stine@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 363 EP - 372 VL - 60 IS - 3 KW - Triazines KW - 0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Swine KW - Animals KW - No-Observed-Adverse-Effect Level KW - Kidney -- pathology KW - Kidney -- drug effects KW - Male KW - Kidney Calculi -- pathology KW - Triazines -- toxicity KW - Kidney Calculi -- chemically induced KW - Animal Feed -- toxicity KW - Kidney Calculi -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876192561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+No+Observable+Adverse+Effects+Level+%28NOAEL%29+for+pigs+fed+melamine+and+cyanuric+acid.&rft.au=Stine%2C+Cynthia+B%3BReimschuessel%2C+Renate%3BGieseker%2C+Charles+M%3BEvans%2C+Eric+R%3BMayer%2C+Tamara+D%3BHasbrouck%2C+Nicholas+R%3BTall%2C+Elizabeth%3BBoehmer%2C+Jamie%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BWard%2C+Jeffrey+L&rft.aulast=Stine&rft.aufirst=Cynthia&rft.date=2011-08-01&rft.volume=60&rft.issue=3&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-15 N1 - Date created - 2011-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.05.004 ER - TY - JOUR T1 - A dose-response study in animals to evaluate the anticoagulant effect of the stage 2 unfractionated heparin USP monograph change. AN - 876192530; 21549797 AB - The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo consequences of the monograph change, we evaluated activated partial thromboplastin time (aPTT) and activated clotting time (ACT) responses in animals. Female mini-pigs and monkeys (n=8/species) were administered intravenously 60, 54, 48, or 42 U/kg and 50, 45, 40, or 35 U/kg "old" (pre-USP revision) UFH, respectively, in a Williams 4×4 crossover design. Blood samples for aPTT and ACT were collected at 15 min after dosing. The same study design was then repeated using "new" (post-USP revision) UFH. Mean "new" UFH aPTT and ACT values were generally lower than those for "old" UFH although individual animal responses varied considerably. The aPTT and ACT response was generally dose-proportional for both "old" and "new" UFH. These studies indicate that the USP monograph alteration for UFH may result in a modest reduction in the anticoagulant response across a population, but the variability in animal responses underscores the importance of individualization of clinical UFH dosing and the importance of anticoagulant test monitoring. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Honchel, R AU - Carraway, J AU - Gopee, N AU - Callicott, R AU - Chen, J AU - Patton, R AU - Xu, Q AU - Zalkkar, J AU - Laniyonu, A AU - Krefting, I AU - Cato, M AU - Robie-Suh, K AU - Rieves, R AD - Division of Medical Imaging Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. ronald.honchel@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 318 EP - 322 VL - 60 IS - 3 KW - Anticoagulants KW - 0 KW - Heparin KW - 9005-49-6 KW - Index Medicus KW - United States KW - Swine KW - Drug Monitoring -- methods KW - Animals KW - Partial Thromboplastin Time -- methods KW - Dose-Response Relationship, Drug KW - Blood Coagulation -- drug effects KW - Whole Blood Coagulation Time -- methods KW - Haplorhini KW - Female KW - Anticoagulants -- toxicity KW - Heparin -- toxicity KW - Heparin -- pharmacology KW - Anticoagulants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876192530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+dose-response+study+in+animals+to+evaluate+the+anticoagulant+effect+of+the+stage+2+unfractionated+heparin+USP+monograph+change.&rft.au=Honchel%2C+R%3BCarraway%2C+J%3BGopee%2C+N%3BCallicott%2C+R%3BChen%2C+J%3BPatton%2C+R%3BXu%2C+Q%3BZalkkar%2C+J%3BLaniyonu%2C+A%3BKrefting%2C+I%3BCato%2C+M%3BRobie-Suh%2C+K%3BRieves%2C+R&rft.aulast=Honchel&rft.aufirst=R&rft.date=2011-08-01&rft.volume=60&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-15 N1 - Date created - 2011-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.04.008 ER - TY - RPRT T1 - Defining and Measuring Quality: An In-Depth Study of Five Child Care Quality Rating and Improvement Systems. OPRE Report 2011-29 AN - 1826531295; ED566254 AB - Quality measurement serves as a foundation for child care Quality Rating and Improvement Systems (QRIS). Understanding the variation that exists in quality measurement, the different contexts in which states make decisions, and the factors that play into their decisions can help administrators identify where their state may fall along the spectrum in practice (or the direction in which they should steer), and can help researchers design approaches that take these differences into account. Such information can also aid in identifying opportunities for moving toward some common practice and research goals. The quality components included in a QRIS define a state's framework for measuring quality and signal to providers and parents the practices that should be included in high-quality early child care and education programs. There are commonalities in the quality categories that are included across QRIS (Tout et al. 2010), demonstrating that many states and communities are using a similar foundation upon which to build their rating systems. However, the manner in which states and localities combine and aggregate these quality categories to develop QRIS ratings has many nuances, producing rating systems with important variations that can impede direct cross-QRIS comparisons and research approaches. Recognizing the need for information on the quality measurement practices in QRIS, this in-depth study of select QRIS was launched as part of the Child Care Quality Rating Systems (QRS) Assessment project, funded by the Office of Planning, Research, and Evaluation (OPRE) within the Administration for Children and Families. Approaches used by states and communities to measure quality through the QRIS were examined by focusing on three research questions: (1) What is the variation in how select QRIS define and measure quality, and what accounts for the variation in their approaches?; (2) What are the specific processes used by select QRIS to measure each component of the quality rating and determine the overall rating level?; and (3) What is the availability of consistent and reliable data on quality ratings within select QRIS and how are the data currently being used? To answer these questions, five QRIS were selected for the in-depth study: Miami-Dade County, Florida; Illinois; Indiana; Pennsylvania; and Tennessee. A summary of key characteristics of the five QRIS is presented. Licensing and NAEYC Accreditation Requirements for Center-Based Programs are appended. AU - Caronongan, Pia AU - Kirby, Gretchen AU - Malone, Lizabeth M. AU - Boller, Kimberly Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 110 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Florida KW - Illinois KW - Indiana KW - Pennsylvania KW - Tennessee KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Reliability KW - Validity KW - Child Care KW - Measurement Techniques KW - Data KW - Rating Scales KW - Access to Information KW - Information Utilization KW - Evaluation Criteria KW - Data Collection KW - Data Analysis KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826531295?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Investments in Behavioral Health Services: Strengthening the Safety Net AN - 1823506446; 201120998 AB - As the primary Federal agency at the U.S. Department of Health and Human Services for improving access to health care services to the medically, financially and geographically vulnerable, the Health Resources and Services Administration (HRSA) is committed to improving health outcomes and achieving health equity by funding access to quality services, a skilled health workforce, and innovative delivery programs. Furthermore, HRSA recognizes the importance of access to quality behavioral health services. This article describes HRSA's current efforts to address behavioral health needs within the safety net through the delivery of quality health services and a strengthened workforce. Also, it highlights HRSA's commitment to providing good quality mental health and substance abuse services through key federal and nonfederal partnerships. [Copyright Elsevier B.V.] JF - Psychological Services AU - Wakefield, Mary K AD - Health Resources and Services Administration mwakefield@hrsa.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 260 EP - 267 PB - Educational Publishing Foundation/American Psychological Association, Washington DC VL - 8 IS - 3 SN - 1541-1559, 1541-1559 KW - Health Resources and Services Administration behavioral health services mental health and substance abuse federal partnerships safety net KW - Occupational health and safety KW - Labour force KW - Social services KW - Health services KW - Federal agencies KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823506446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Services&rft.atitle=Investments+in+Behavioral+Health+Services%3A+Strengthening+the+Safety+Net&rft.au=Wakefield%2C+Mary+K&rft.aulast=Wakefield&rft.aufirst=Mary&rft.date=2011-08-01&rft.volume=8&rft.issue=3&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Psychological+Services&rft.issn=15411559&rft_id=info:doi/10.1037%2Fa0024793 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Occupational health and safety; Health services; Social services; Labour force; Substance abuse; Federal agencies DO - http://dx.doi.org/10.1037/a0024793 ER - TY - JOUR T1 - Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States AN - 1257729675; 16700913 AB - Keywords: acetaminophen overdose; liver toxicity; hospitalizations; emergency department visits ABSTRACT Purpose To estimate the number of acetaminophen overdose-related emergency department (ED) visits and hospitalizations in the United States, characterize these by intentionality, age, and gender, and compare the strengths and limitations of the utilized databases. Methods We used data from the National Hospital Ambulatory Medical Care Survey (NHAMCS) and the National Electronic Injury Surveillance System (NEISS) to estimate the number of relevant ED visits in the United States between 2000 and 2007, and the National Hospital Discharge Survey (NHDS) to estimate the number of relevant hospitalizations in the United States between 1991 and 2006. National estimates and their standard errors were calculated using information provided in each database. We used the standard United States population in 2000 to calculate age-adjusted rates. Results We estimate an annual average of 44348 (NHAMCS, 2000-2007) or 78414 (NEISS, 2006-2007) acetaminophen overdose-related ED visits and 33520 (NHDS, 2000-2006) hospitalizations. For 2000-2006 we calculated an age-adjusted rate of 13.9 acetaminophen overdose-related hospitalizations per 100000 US population, with the highest rate (15.7) occurring from 2005 to 2006. Between 1991 and 2006, there was no decrease noted in hospitalizations for intentional or unintentional overdoses. The majority of overdoses reported in NEISS (69.8%) and NHDS (74.2%) were classified as intentional (suicides or suicidal gestures), whereas in NHAMCS, intentionality was evenly distributed. Conclusions Our results suggest that acetaminophen overdose, both intentional and unintentional, remains a significant public health concern. With an understanding of their methodological characteristics and limitations, these national databases can be useful tools to characterize acetaminophen overdose-related ED visits and hospitalizations. Published in 2011 by John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and Drug Safety AU - Anon., Anon AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA, angelika.manthripragada@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 819 EP - 826 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 20 IS - 8 SN - 1099-1557, 1099-1557 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Age KW - Data processing KW - Injuries KW - Suicide KW - Toxicity KW - Public health KW - Databases KW - USA KW - Overdose KW - Gender KW - Liver KW - Acetaminophen KW - Emergency medical services KW - Hospitals KW - X 24310:Pharmaceuticals KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257729675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Characterization+of+acetaminophen+overdose-related+emergency+department+visits+and+hospitalizations+in+the+United+States&rft.au=Anon.%2C+Anon&rft.aulast=Anon.&rft.aufirst=Anon&rft.date=2011-08-01&rft.volume=20&rft.issue=8&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10991557&rft_id=info:doi/10.1002%2Fpds.2090 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pds.2090/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Databases; Age; Overdose; Data processing; Injuries; Liver; Suicide; Toxicity; Acetaminophen; Public health; Hospitals; Gender; Emergency medical services; USA DO - http://dx.doi.org/10.1002/pds.2090 ER - TY - JOUR T1 - An improved immunoassay for detection of saxitoxin by surface plasmon resonance biosensors AN - 1028076641; 15160156 AB - Saxitoxin and its analogs, the causative agents of paralytic shellfish poisoning (PSP), are a worldwide threat to seafood safety. Effective monitoring of potentially contaminated fishing areas as well as screening of seafood samples is necessary to adequately protect the public. While many analytical methods exist for detecting paralytic shellfish toxins (PSTs), each technique has challenges associated with routine use. One recently developed method that overcomes ethical or performance-related issues of other techniques is the surface plasmon resonance (SPR) bioassay. Notwithstanding the advantages of this method, much research remains in optimizing the sensor substrate and assay conditions to create a robust technique for rapid and sensitive measurement of PSTs. This manuscript describes a more rigorous and stable SPR inhibition immunoassay through optimization of the surface chemistry as well as determination of optimum mixture ratios and mixing times. The final system provides rapid substrate formation (18h saxitoxin conjugation with low reagent consumption), contains a reference channel for each assay, and is capable of triplicate measurements in a single run with detection limits well below the regulatory action level. JF - Sensors and Actuators B: Chemical AU - Yakes, Betsy Jean AU - Prezioso, Samantha AU - Haughey, Simon A AU - Campbell, Katrina AU - Elliott, Christopher T AU - DeGrasse, Stacey L AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 805 EP - 811 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 156 IS - 2 SN - 0925-4005, 0925-4005 KW - Biotechnology and Bioengineering Abstracts KW - Biosensors KW - Saxitoxin KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028076641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sensors+and+Actuators+B%3A+Chemical&rft.atitle=An+improved+immunoassay+for+detection+of+saxitoxin+by+surface+plasmon+resonance+biosensors&rft.au=Yakes%2C+Betsy+Jean%3BPrezioso%2C+Samantha%3BHaughey%2C+Simon+A%3BCampbell%2C+Katrina%3BElliott%2C+Christopher+T%3BDeGrasse%2C+Stacey+L&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2011-08-01&rft.volume=156&rft.issue=2&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Sensors+and+Actuators+B%3A+Chemical&rft.issn=09254005&rft_id=info:doi/10.1016%2Fj.snb.2011.02.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Saxitoxin DO - http://dx.doi.org/10.1016/j.snb.2011.02.043 ER - TY - JOUR T1 - State-of-the-art therapeutic medical countermeasures for bacterial threat agents AN - 1028021703; 16695309 AB - In the event of another bioterrorism attack with a bacterial agent, antibiotics will be critical medical countermeasures to have in the US Strategic National Stockpile. Conventional antibiotics such as ciprofloxacin, doxycycline, and streptomycin are generally considered a first line of defense against organisms such as Bacillus anthracis and Yersinia pestis. However, antibiotic resistance is a growing public health threat, especially among potentially life-threatening pathogens; it is possible that threat agent bacteria could naturally evolve, or be engineered to express, antibiotic resistance against commonly used antibiotics. At the same time that the need for novel or improved antibiotics is becoming urgent, the antibiotic development pipeline has slowed, with only two completely new classes of antibiotics having been introduced over the past 40 years. In the present work, we review the current antibiotic pipeline, including novel, innovative approaches being considered to target bacteria or virulence, with a focus on those compounds that have been tested for activity against threat agent bacteria. We opine on the benefits and challenges inherent in certain mechanisms of action and stress that regulatory, policy, and technical strategies need to be revisited in order to incentivize industry to continue antibiotic development. Drug Dev Res 72: 361-378, 2011.? 2011 Wiley-Liss, Inc. JF - Drug Development Research AU - Stundick, Melissa V AU - Metz, Matthew AU - Sampath, Aruna AU - Larsen, Joseph C AD - U.S. Department of Health and Human Services, Office of the Assistant Secretary for Preparedness and Response, Biomedical Advanced Research and Development Authority, Washington, DC 20201, joseph.larsen@hhs.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 361 EP - 378 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 72 IS - 5 SN - 1098-2299, 1098-2299 KW - Microbiology Abstracts B: Bacteriology KW - Antibiotic resistance KW - Antibiotics KW - Ciprofloxacin KW - Doxycycline KW - Drug development KW - Drugs KW - Pathogens KW - Public health KW - Reviews KW - Streptomycin KW - Virulence KW - bioterrorism KW - Yersinia pestis KW - Bacillus anthracis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028021703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=State-of-the-art+therapeutic+medical+countermeasures+for+bacterial+threat+agents&rft.au=Stundick%2C+Melissa+V%3BMetz%2C+Matthew%3BSampath%2C+Aruna%3BLarsen%2C+Joseph+C&rft.aulast=Stundick&rft.aufirst=Melissa&rft.date=2011-08-01&rft.volume=72&rft.issue=5&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=10982299&rft_id=info:doi/10.1002%2Fddr.20462 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ddr.20462/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - Virulence; Ciprofloxacin; bioterrorism; Reviews; Drug development; Antibiotics; Streptomycin; Pathogens; Drugs; Doxycycline; Antibiotic resistance; Public health; Yersinia pestis; Bacillus anthracis DO - http://dx.doi.org/10.1002/ddr.20462 ER - TY - JOUR T1 - Fukuoka-1 strain of transmissible spongiform encephalopathy agent infects murine bone marrow-derived cells with features of mesenchymal stem cells AN - 1020838238; 15735878 AB - BACKGROUND: The possible risk of iatrogenic transmissible spongiform encephalopathies (TSEs, prion diseases) from transplantation of marrow-derived mesenchymal stem cells (MSCs) is uncertain. While most cell lines resist infection, a few propagate TSE agents. STUDY DESIGN AND METHODS: We generated MSC-like (MSC-L) cell cultures from bone marrow (BM) of mice inoculated with the human-derived Fukuoka-1 (Fu) strain of TSE agent. Cultured cells were characterized for various markers and cellular prion protein (PrPC) by fluorescence-activated cell sorting and for PrPC and its pathologic TSE-associated form (PrPTSE) by Western blotting (WB). Cell cultures were tested for their susceptibility to infection with Fu in vitro. The infectivity of one Fu-infected cell culture was assayed in mice. RESULTS: BM cells from Fu-infected mice expressed neither PrPC nor PrPTSE after 3 days in culture as demonstrated by WB. Cells adherent to plastic and maintained under two different culture conditions became spontaneously immortalized and began to express PrPC at about the same time. One culture became transformed shortly after exposure to Fu in vitro and remained persistently infected, continuously generating PrPTSE through multiple passages; the infectivity of cultured cells was confirmed by intracerebral inoculation of lysates into mice. Both persistently TSE-infected and uninfected cells expressed a number of typical MSC markers. CONCLUSION: BM-derived MSC-L cells of mice became persistently infected with the Fu agent under certain conditions in culture-conditions that differ substantially from those currently used to develop investigational human stem cell therapies. JF - Transfusion AU - Cervenakova, Larisa AU - Akimov, Sergey AU - Vasilyeva, Irina AU - Yakovleva, Oksana AU - McKenzie, Carroll AU - Cervenak, Juraj AU - Piccardo, Pedro AU - Asher, David M AD - From the Transmissible Diseases Department, American Red Cross Holland Laboratory, Rockville, Maryland; the Laboratory of Bacterial and Transmissible Spongiform Encephalopathy Agents, DETTD, OBRR, CBER, US Food and Drug Administration (FDA), Kensington, Maryland; and the Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 1755 EP - 1768 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 8 SN - 0041-1132, 0041-1132 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Bone marrow KW - Cell culture KW - Flow cytometry KW - Infection KW - Infectivity KW - Inoculation KW - Mesenchyme KW - Plastics KW - Prion protein KW - Stem cells KW - Transmissible spongiform encephalopathy KW - Western blotting KW - W 30920:Tissue Engineering KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020838238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Fukuoka-1+strain+of+transmissible+spongiform+encephalopathy+agent+infects+murine+bone+marrow-derived+cells+with+features+of+mesenchymal+stem+cells&rft.au=Cervenakova%2C+Larisa%3BAkimov%2C+Sergey%3BVasilyeva%2C+Irina%3BYakovleva%2C+Oksana%3BMcKenzie%2C+Carroll%3BCervenak%2C+Juraj%3BPiccardo%2C+Pedro%3BAsher%2C+David+M&rft.aulast=Cervenakova&rft.aufirst=Larisa&rft.date=2011-08-01&rft.volume=51&rft.issue=8&rft.spage=1755&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.03041.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Document feature - figure 6 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Transmissible spongiform encephalopathy; Western blotting; Infectivity; Stem cells; Inoculation; Bone marrow; Prion protein; Cell culture; Plastics; Infection; Mesenchyme DO - http://dx.doi.org/10.1111/j.1537-2995.2010.03041.x ER - TY - JOUR T1 - The Looming Expansion And Transformation Of Public Substance Abuse Treatment Under The Affordable Care Act AN - 1018364467; 201202545 AB - Public substance abuse treatment services have largely operated as an independent part of the overall health care system, with unique methods of administration, funding, and service delivery. The Affordable Care Act of 2010 and other recent health care reforms, coupled with declines in state general revenue spending, will change this. Overall funding for these substance abuse services should increase, and they should be better integrated into the mainstream of general health care. Reform provisions are also likely to expand the variety of substance abuse treatment providers and shift services away from residential and stand-alone programs toward outpatient programs and more integrated programs or care systems. As a result, patients should have better access to care that is more medically based and person-centered. Adapted from the source document. JF - Health Affairs AU - Buck, Jeffrey A AD - Centers for Medicare and Medicaid Services, in Baltimore, Maryland jeffrey.buck@cms.hhs.gov Y1 - 2011/08// PY - 2011 DA - August 2011 SP - 1402 EP - 1410 PB - Project HOPE, Bethesda MD VL - 30 IS - 8 SN - 0278-2715, 0278-2715 KW - Outpatients KW - Expenditures KW - Substance Abuse KW - Treatment Programs KW - Delivery Systems KW - Access KW - Treatment KW - Reform KW - Health Care Services KW - article KW - 6129: illness & health care KW - 6140: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018364467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=The+Looming+Expansion+And+Transformation+Of+Public+Substance+Abuse+Treatment+Under+The+Affordable+Care+Act&rft.au=Buck%2C+Jeffrey+A&rft.aulast=Buck&rft.aufirst=Jeffrey&rft.date=2011-08-01&rft.volume=30&rft.issue=8&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0480 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Substance Abuse; Treatment Programs; Health Care Services; Treatment; Reform; Expenditures; Access; Delivery Systems; Outpatients DO - http://dx.doi.org/10.1377/hlthaff.2011.0480 ER - TY - JOUR T1 - Juvenile animal studies and pediatric drug development retrospective review: use in regulatory decisions and labeling AN - 1017973994; 16712409 AB - Juvenile animal toxicity studies are conducted to support applications for drugs intended for use in children. They are designed to address specific questions of potential toxicity in the growing animal or provide data about long-term safety effects of drugs that cannot be obtained from clinical trials. Decisions to conduct a juvenile animal study are based on existing data, such as a safety signal already identified in adult studies, or previous knowledge of the drug or chemical class for its potential to impair growth or developmental milestones. In 2006, the FDA issued an industry guidance in which considerations for determining when a juvenile animal study is warranted were outlined. A retrospective study was conducted covering years both before and after the issued guideline to examine the contribution of juvenile animal toxicity studies to the risk/benefit assessment of pediatric drugs at the FDA. The initial findings were presented as part of the May 2010 HESI workshop on the value of juvenile animal studies. The objective of the review was to better understand the value that the juvenile animal study contributes to regulatory decision making for pediatric drug development by looking at when the studies have been included in the product assessment; what, if any, impact the studies had on the regulatory decisions made; and whether the data were incorporated into the label. The data described below represent a first look at impact of the juvenile animal study since the pediatric legislation and the juvenile animal guidance were issued in the US. Birth Defects Res (Part B) 92:261-265, 2011. ? 2011 Wiley-Liss, Inc. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Tassinari, Melissa S AU - Benson, Kimberly AU - Elayan, Ikram AU - Espandiari, Parvaneh AU - Davis-Bruno, Karen AD - Pediatric and Maternal Health Staff, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, melissa.tassinari@fda.hhs.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 261 EP - 265 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 92 IS - 4 SN - 1542-9741, 1542-9741 KW - Toxicology Abstracts KW - Children KW - Clinical trials KW - Conferences KW - Congenital defects KW - Data processing KW - Decision making KW - Drug development KW - Drug screening KW - Drugs KW - Legislation KW - Pediatrics KW - Reviews KW - Risk assessment KW - Toxicity KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017973994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Juvenile+animal+studies+and+pediatric+drug+development+retrospective+review%3A+use+in+regulatory+decisions+and+labeling&rft.au=Tassinari%2C+Melissa+S%3BBenson%2C+Kimberly%3BElayan%2C+Ikram%3BEspandiari%2C+Parvaneh%3BDavis-Bruno%2C+Karen&rft.aulast=Tassinari&rft.aufirst=Melissa&rft.date=2011-08-01&rft.volume=92&rft.issue=4&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429741&rft_id=info:doi/10.1002%2Fbdrb.20304 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20304/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Conferences; Pediatrics; Drug development; Toxicity; Children; Drug screening; Clinical trials; Decision making; Reviews; Congenital defects; Drugs; Legislation DO - http://dx.doi.org/10.1002/bdrb.20304 ER - TY - JOUR T1 - Infrared imaging for leak detection of N95 filtering facepiece respirators: A pilot study AN - 1017962632; 16691535 AB - Background This study was undertaken to determine the utility of an infrared camera (IRC) for assessing leaks around filtering facepiece respirators (FFR) during quantitative respirator fit testing. Methods Eight subjects underwent quantitative fit testing on six N95 FFR models (48 total fit tests) while simultaneously being recorded with an IRC. Results The IRC detected 49 exhalation leaks during 39 tests and no leaks in nine tests. Exhalation leaks were identified in all failed fit tests (13) and a majority (26 of 35) of passed tests. Anatomically, the nasal region and malar (cheekbone) regions accounted for 71% of identified leak sites. Fit factors for fit tests without identified exhalation leaks were significantly higher than fit tests with leaks detected by IRC (P=0.01). Conclusions Thermal imaging using IRC can detect leaks in respiratory protective equipment and has the potential as a screening tool for assessment of the adequacy of post-donning FFR fit. Am. J. Ind. Med. 54:628-636, 2011. ? 2011 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Roberge, Raymond J AU - Monaghan, William D AU - Palmiero, Andrew J AU - Shaffer, Ronald AU - Bergman, Michael S AD - National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health/Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania, dtn0@cdc.gov Y1 - 2011/08// PY - 2011 DA - Aug 2011 SP - 628 EP - 636 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 8 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Leak detection KW - infrared imaging KW - Respirators KW - Protective equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Infrared+imaging+for+leak+detection+of+N95+filtering+facepiece+respirators%3A+A+pilot+study&rft.au=Roberge%2C+Raymond+J%3BMonaghan%2C+William+D%3BPalmiero%2C+Andrew+J%3BShaffer%2C+Ronald%3BBergman%2C+Michael+S&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2011-08-01&rft.volume=54&rft.issue=8&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20970 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20970/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Leak detection; infrared imaging; Respirators; Protective equipment DO - http://dx.doi.org/10.1002/ajim.20970 ER - TY - CPAPER T1 - Noise Survey of Aggregate Industry Vibrating Screens T2 - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AN - 1313026457; 6061076 JF - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AU - Lowe, M AU - Yantek, David Y1 - 2011/07/25/ PY - 2011 DA - 2011 Jul 25 KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313026457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.atitle=Noise+Survey+of+Aggregate+Industry+Vibrating+Screens&rft.au=Lowe%2C+M%3BYantek%2C+David&rft.aulast=Lowe&rft.aufirst=M&rft.date=2011-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc11/documents/2011TechnicalSchedule_online_001.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluations of Noise Controls for Roof Bolting Machines used to drill 25-mm-diameter Holes T2 - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AN - 1313026351; 6061074 JF - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AU - Yantek, David AU - Alcorn, Lynn AU - Azman, Amanda Y1 - 2011/07/25/ PY - 2011 DA - 2011 Jul 25 KW - Noise levels KW - Bolting KW - Drills UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313026351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.atitle=Evaluations+of+Noise+Controls+for+Roof+Bolting+Machines+used+to+drill+25-mm-diameter+Holes&rft.au=Yantek%2C+David%3BAlcorn%2C+Lynn%3BAzman%2C+Amanda&rft.aulast=Yantek&rft.aufirst=David&rft.date=2011-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc11/documents/2011TechnicalSchedule_online_001.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Laboratory Measurements of Air Carbon Arcing Sound Power Levels T2 - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AN - 1313010577; 6061072 JF - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AU - Miller, Richard AU - Peterson, J Y1 - 2011/07/25/ PY - 2011 DA - 2011 Jul 25 KW - Carbon KW - Sound UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313010577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.atitle=Laboratory+Measurements+of+Air+Carbon+Arcing+Sound+Power+Levels&rft.au=Miller%2C+Richard%3BPeterson%2C+J&rft.aulast=Miller&rft.aufirst=Richard&rft.date=2011-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc11/documents/2011TechnicalSchedule_online_001.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Noise Source Identifi cation and Assessment of Two Noise Controls for Jack Hammers T2 - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AN - 1312983942; 6061030 JF - 2011 Annual Conference of the Institute of Noise Control Engineering's (NOISE-CON 2011) AU - Zechmann, Edward AU - Hemmelgarn, Andrew AU - Hayden, Charles Y1 - 2011/07/25/ PY - 2011 DA - 2011 Jul 25 KW - Noise levels KW - Cations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.atitle=Noise+Source+Identifi+cation+and+Assessment+of+Two+Noise+Controls+for+Jack+Hammers&rft.au=Zechmann%2C+Edward%3BHemmelgarn%2C+Andrew%3BHayden%2C+Charles&rft.aulast=Zechmann&rft.aufirst=Edward&rft.date=2011-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Conference+of+the+Institute+of+Noise+Control+Engineering%27s+%28NOISE-CON+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc11/documents/2011TechnicalSchedule_online_001.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Comparative analysis of predictive models for nongenotoxic hepatocarcinogenicity using both toxicogenomics and quantitative structure-activity relationships. AN - 878034357; 21627106 AB - The primary testing strategy to identify nongenotoxic carcinogens largely relies on the 2-year rodent bioassay, which is time-consuming and labor-intensive. There is an increasing effort to develop alternative approaches to prioritize the chemicals for, supplement, or even replace the cancer bioassay. In silico approaches based on quantitative structure-activity relationships (QSAR) are rapid and inexpensive and thus have been investigated for such purposes. A slightly more expensive approach based on short-term animal studies with toxicogenomics (TGx) represents another attractive option for this application. Thus, the primary questions are how much better predictive performance using short-term TGx models can be achieved compared to that of QSAR models, and what length of exposure is sufficient for high quality prediction based on TGx. In this study, we developed predictive models for rodent liver carcinogenicity using gene expression data generated from short-term animal models at different time points and QSAR. The study was focused on the prediction of nongenotoxic carcinogenicity since the genotoxic chemicals can be inexpensively removed from further development using various in vitro assays individually or in combination. We identified 62 chemicals whose hepatocarcinogenic potential was available from the National Center for Toxicological Research liver cancer database (NCTRlcdb). The gene expression profiles of liver tissue obtained from rats treated with these chemicals at different time points (1 day, 3 days, and 5 days) are available from the Gene Expression Omnibus (GEO) database. Both TGx and QSAR models were developed on the basis of the same set of chemicals using the same modeling approach, a nearest-centroid method with a minimum redundancy and maximum relevancy-based feature selection with performance assessed using compound-based 5-fold cross-validation. We found that the TGx models outperformed QSAR in every aspect of modeling. For example, the TGx models' predictive accuracy (0.77, 0.77, and 0.82 for the 1-day, 3-day, and 5-day models, respectively) was much higher for an independent validation set than that of a QSAR model (0.55). Permutation tests confirmed the statistical significance of the model's prediction performance. The study concluded that a short-term 5-day TGx animal model holds the potential to predict nongenotoxic hepatocarcinogenicity. © 2011 American Chemical Society JF - Chemical research in toxicology AU - Liu, Zhichao AU - Kelly, Reagan AU - Fang, Hong AU - Ding, Don AU - Tong, Weida AD - Center of Excellence for Bioinformatics, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. Y1 - 2011/07/18/ PY - 2011 DA - 2011 Jul 18 SP - 1062 EP - 1070 VL - 24 IS - 7 KW - Carcinogens KW - 0 KW - Index Medicus KW - Rats KW - Models, Animal KW - Software KW - Gene Expression Profiling KW - Animals KW - Toxicity Tests KW - Databases, Factual KW - Mice KW - Time Factors KW - Quantitative Structure-Activity Relationship KW - Liver -- drug effects KW - Carcinogens -- toxicity KW - Toxicogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878034357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Comparative+analysis+of+predictive+models+for+nongenotoxic+hepatocarcinogenicity+using+both+toxicogenomics+and+quantitative+structure-activity+relationships.&rft.au=Liu%2C+Zhichao%3BKelly%2C+Reagan%3BFang%2C+Hong%3BDing%2C+Don%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2011-07-18&rft.volume=24&rft.issue=7&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx2000637 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-09 N1 - Date created - 2011-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx2000637 ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: Compounds with moderate to low opioid-receptor affinity AN - 883043073; 15320523 AB - N-Phenethyl-substituted ortho-a and para-a oxide-bridged phenylmorphans have been obtained through an improved synthesis and their binding affinity examined at the various opioid receptors. Although the N-phenethyl substituent showed much greater affinity for mu - and Kappa -opioid receptors than their N-methyl relatives (e.g., K sub(i = 167 nM and 171 nM at mu - and Kappa -receptors vs 2800 and 7500 nM for the N-methyl ortho-a oxide-bridged phenylmorphan), the a-isomers were not examined further because of their relatively low affinity. The N-phenethyl substituted ortho-b and para-b oxide-bridged phenylmorphans were also synthesized and their enantiomers were obtained using supercritical fluid chromatography. Of the four enantiomers, only the (+)-ortho-b isomer had moderate affinity for mu - and Kappa -receptors (K) sub(i) = 49 and 42 nM, respectively, and it was found to also have moderate mu - and Kappa -opioid antagonist activity in the [ super(35S]GTP- gamma -S assay (K) sub(e) = 31 and 26 nM). JF - Bioorganic and Medicinal Chemistry AU - Li, Feng AU - Folk, John E AU - Cheng, Kejun AU - Kurimura, Muneaki AU - Deck, Jason A AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 4330 EP - 4337 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 19 IS - 14 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Opioid receptors KW - Enantiomers KW - Chromatography KW - Probes KW - Isomers KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883043073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+43.+Synthesis+of+the+ortho-a+and+para-a%2C+and+improved+synthesis+and+optical+resolution+of+the+ortho-b+and+para-b+oxide-bridged+phenylmorphans%3A+Compounds+with+moderate+to+low+opioid-receptor+affinity&rft.au=Li%2C+Feng%3BFolk%2C+John+E%3BCheng%2C+Kejun%3BKurimura%2C+Muneaki%3BDeck%2C+Jason+A%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Li&rft.aufirst=Feng&rft.date=2011-07-15&rft.volume=19&rft.issue=14&rft.spage=4330&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2011.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Enantiomers; Chromatography; Probes; Isomers DO - http://dx.doi.org/10.1016/j.bmc.2011.05.035 ER - TY - JOUR T1 - Bioavailability of soy isoflavones through placental/lactational transfer and soy food. AN - 876185903; 21034763 AB - Isoflavones are non-nutritive components of soy responsible for estrogenic responses observed in vitro and in experimental animals. Possible beneficial effects (e.g., reduction of serum lipids, increased bone mineral density, relief of hot flashes and other menopausal symptoms, mammary and prostate cancer chemoprevention) in humans have been attributed to consumption of isoflavones but evidence for potential adverse effects (e.g., stimulation of estrogen-dependent mammary tumors and aberrant perinatal development) has also been reported in experimental animal models. Bioavailability from appropriate food matrices and exposure during different life stages are both critical determinants of isoflavone effects. For these reasons, it is important to compare isoflavone bioavailability in adults to that in fetal and neonatal animals for a more complete understanding of potential susceptibility issues. Studies of the major soy isoflavone genistein were conducted in pregnant and lactating Sprague-Dawley rats to quantify placental and lactational transfer to plasma and brain to understand better biological effects observed in multigenerational studies. In addition, studies were conducted with genistein in adult Balb/c mice to define absolute bioavailability from both gavage and soy protein isolate (SPI)-containing food. The information derived from these studies makes it possible to predict internal exposures of children to genistein from soy infant formula, which is manufactured using SPI. Copyright © 2011 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Doerge, Daniel R AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. daniel.doerge@fda.hhs.gov Y1 - 2011/07/15/ PY - 2011 DA - 2011 Jul 15 SP - 145 EP - 147 VL - 254 IS - 2 KW - Isoflavones KW - 0 KW - Index Medicus KW - Animals KW - Infant Formula -- metabolism KW - Humans KW - Infant, Newborn KW - Female KW - Pregnancy KW - Lactation -- metabolism KW - Soy Foods KW - Isoflavones -- metabolism KW - Placenta -- metabolism KW - Maternal-Fetal Exchange -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876185903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Bioavailability+of+soy+isoflavones+through+placental%2Flactational+transfer+and+soy+food.&rft.au=Doerge%2C+Daniel+R&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2011-07-15&rft.volume=254&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2010.10.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-06 N1 - Date created - 2011-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2010.10.018 ER - TY - JOUR T1 - Comparative analysis of micronuclei and DNA damage induced by Ochratoxin A in two mammalian cell lines AN - 899166023; 15160920 AB - The fungal toxin, Ochratoxin A (OTA), is a common contaminant in human food and animal feed. The present study evaluated micronucleus (MN) induction by OTA in comparison with its ability to induce cytotoxicity and DNA damage in two mammalian cell lines, CHO-K1-BH4 Chinese hamster ovary cells and TK6 human lymphoblastoid cells. Micronuclei were evaluated by flow cytometry, cytotoxicity was estimated by relative population doubling (RPD), while direct DNA damage and oxidative DNA damage were measured with the Comet assay, performed without and with digestion by formamidopyrimidine-DNA glycosylase (fpg). For the MN and cytotoxicity measurements, the cell lines were treated for 24h (CHO cells) or 27h (TK6 cells) with 5-25 mu M OTA in the absence of exogenous metabolic activation. The OTA treatments resulted in concentration-responsive increases in cytotoxicity, with higher concentrations of the agent being more cytotoxic in CHO cells than TK6 cells. 15 mu M OTA produced positive responses for MN induction and hypodiploid events (a measure of aneugenicity) in both cell lines; this concentration of OTA also produced cytotoxicity near to the recommended limit for the assay (45+/-5% RPD). A time course assay with TK6 cells indicated that at least 4h of OTA treatment were required to produce a positive MN response. For the Comet assay DNA damage assessments, the cell lines were treated with 5-50 mu M OTA for 4h. Direct DNA damage was detected in TK6 cells, but not CHO cells, while concentration-related increases in fpg-sensitive sites were detected for both cell lines. The consistent association of oxidative DNA damage with OTA exposure suggests its involvement in producing OTA-induced clastogenicity and aneugenicity; however, based on its detection in TK6 cells direct DNA damage could be involved in any human risk posed by OTA exposure. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Ali, Rahat AU - Mittelstaedt, Roberta A AU - Shaddock, Joseph G AU - Ding, Wei AU - Bhalli, Javed A AU - Khan, Qaiser M AU - Heflich, Robert H AD - National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan, Robert.Heflich@fda.hhs.gov Y1 - 2011/07/14/ PY - 2011 DA - 2011 Jul 14 SP - 58 EP - 64 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 723 IS - 1 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - Ochratoxin A KW - Micronuclei KW - Food contamination KW - Toxins KW - Mutagenesis KW - Digestion KW - Flow cytometry KW - DNA damage KW - Cytotoxicity KW - Mammalian cells KW - Clastogenicity KW - formamidopyrimidine-DNA glycosylase KW - Metabolic activation KW - Comet assay KW - Manganese KW - X 24370:Natural Toxins KW - N 14820:DNA Metabolism & Structure KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899166023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Comparative+analysis+of+micronuclei+and+DNA+damage+induced+by+Ochratoxin+A+in+two+mammalian+cell+lines&rft.au=Ali%2C+Rahat%3BMittelstaedt%2C+Roberta+A%3BShaddock%2C+Joseph+G%3BDing%2C+Wei%3BBhalli%2C+Javed+A%3BKhan%2C+Qaiser+M%3BHeflich%2C+Robert+H&rft.aulast=Ali&rft.aufirst=Rahat&rft.date=2011-07-14&rft.volume=723&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Ochratoxin A; Micronuclei; Food contamination; Toxins; Mutagenesis; Flow cytometry; Digestion; DNA damage; Cytotoxicity; Mammalian cells; Clastogenicity; Metabolic activation; formamidopyrimidine-DNA glycosylase; Comet assay; Manganese DO - http://dx.doi.org/10.1016/j.mrgentox.2011.04.002 ER - TY - JOUR T1 - Expression optimisation of recombinant alpha -L-arabinofuranosidase from Aspergillus niger ATCC 120120 in Pichia pastoris and its biochemical characterisation AN - 907191111; 16074348 AB - A gene encoding alpha -L-arabinofuranosidase (AnabfA) from Aspergillus niger ATCC 120120 was successfully cloned and expressed in Pichia pastoris under the control of the AOX1 promoter. The effect of cultural conditions on recombinant AnabfA production was studied and the enzyme was expressed as a soluble protein. Recombinant AnabfA was expressed as an active enzyme at 28 degree C when cultured in BMMY medium (pH 6.0) and induced with 2% methanol every 24 h. Maximum activity was observed 5 days after induction. The purified recombinant AnabfA before and after treatment with PNGase F migrated by SDS-PAGE had relative molecular masses of about 83 and 66 kDa, respectively, suggesting that the AnabfA contains N-linked oligosaccharides. Characterisation of the purified recombinant AnabfA showed an optimum temperature and pH of 50 degree C and 4, respectively. The enzyme was stable at a pH of 3 to 6 and retained more than 80% of its activity after pre-incubation at 40 degree C for 30 min. The recombinant AnabfA activity was stimulated by K super(+), Mn super(2+), Na super(2+) and triton X-100 and was strongly inhibited by Cu super(2+) and Fe super(2+) and the enzyme activity was relatively unaffected by Ca super(2+), CO super(2+), Mg super(2+) and EDTA. The K sub(m) and V sub(max) of the purified recombinant AnabfA activity towards rho NPA were 0.93 mM and 17.86 mu mol/ml/min, respectively. JF - African Journal of Biotechnology AU - Alias, NI AU - Mahadi, N M AU - Murad, AMA AU - Bakar, FDA AU - Rabu, A AU - Illias, R M AD - Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia, r-rosli@utm.my Y1 - 2011/07/13/ PY - 2011 DA - 2011 Jul 13 SP - 6700 EP - 6710 VL - 10 IS - 35 SN - 1684-5315, 1684-5315 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - alpha -N-Arabinofuranosidase KW - oligosaccharides KW - Calcium KW - Methanol KW - Potassium KW - Enzymes KW - Copper KW - Promoters KW - Pichia pastoris KW - Magnesium KW - Iron KW - pH effects KW - Aspergillus niger KW - Edetic acid KW - W 30925:Genetic Engineering KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907191111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=African+Journal+of+Biotechnology&rft.atitle=Expression+optimisation+of+recombinant+alpha+-L-arabinofuranosidase+from+Aspergillus+niger+ATCC+120120+in+Pichia+pastoris+and+its+biochemical+characterisation&rft.au=Alias%2C+NI%3BMahadi%2C+N+M%3BMurad%2C+AMA%3BBakar%2C+FDA%3BRabu%2C+A%3BIllias%2C+R+M&rft.aulast=Alias&rft.aufirst=NI&rft.date=2011-07-13&rft.volume=10&rft.issue=35&rft.spage=6700&rft.isbn=&rft.btitle=&rft.title=African+Journal+of+Biotechnology&rft.issn=16845315&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - alpha -N-Arabinofuranosidase; Temperature effects; Calcium; oligosaccharides; Methanol; Enzymes; Potassium; Copper; Promoters; Magnesium; pH effects; Iron; Edetic acid; Pichia pastoris; Aspergillus niger ER - TY - JOUR T1 - Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. AN - 876833620; 21657258 AB - Carcinogenicity of carbon nanotubes is a major concern but has not been well addressed due to the lack of experimental models. Here, we show that chronic exposure to single-walled carbon nanotubes causes malignant transformation of human lung epithelial cells. The transformed cells induce tumorigenesis in mice and exhibit an apoptosis resistant phenotype characteristic of cancer cells. This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process. JF - Nano letters AU - Wang, Liying AU - Luanpitpong, Sudjit AU - Castranova, Vincent AU - Tse, William AU - Lu, Yongju AU - Pongrakhananon, Varisa AU - Rojanasakul, Yon AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States. Y1 - 2011/07/13/ PY - 2011 DA - 2011 Jul 13 SP - 2796 EP - 2803 VL - 11 IS - 7 KW - Nanotubes, Carbon KW - 0 KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Apoptosis KW - Particle Size KW - Humans KW - Mice, Nude KW - Mice KW - Tumor Suppressor Protein p53 -- metabolism KW - Surface Properties KW - Nanotechnology KW - Epithelial Cells -- metabolism KW - Cell Transformation, Neoplastic -- pathology KW - Nanotubes, Carbon -- chemistry KW - Epithelial Cells -- pathology KW - Cell Transformation, Neoplastic -- metabolism KW - Lung -- pathology KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876833620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+letters&rft.atitle=Carbon+nanotubes+induce+malignant+transformation+and+tumorigenesis+of+human+lung+epithelial+cells.&rft.au=Wang%2C+Liying%3BLuanpitpong%2C+Sudjit%3BCastranova%2C+Vincent%3BTse%2C+William%3BLu%2C+Yongju%3BPongrakhananon%2C+Varisa%3BRojanasakul%2C+Yon&rft.aulast=Wang&rft.aufirst=Liying&rft.date=2011-07-13&rft.volume=11&rft.issue=7&rft.spage=2796&rft.isbn=&rft.btitle=&rft.title=Nano+letters&rft.issn=1530-6992&rft_id=info:doi/10.1021%2Fnl2011214 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-22 N1 - Date created - 2011-07-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 1999 Dec 15;18(24):7002-10 [10601022] Am J Respir Cell Mol Biol. 2010 May;42(5):578-85 [19556603] Oncogene. 2000 Apr 6;19(15):1959-68 [10773886] J Biol Chem. 2000 Jul 7;275(27):20444-9 [10781582] Cancer Res. 2001 Sep 1;61(17):6350-5 [11522624] Oncogene. 2002 Jan 3;21(1):1-8 [11791171] Int Immunopharmacol. 2002 Feb;2(2-3):191-200 [11811924] J Cell Biochem. 2003 Apr 1;88(5):885-98 [12616528] Nat Rev Cancer. 2003 May;3(5):362-74 [12724734] Virchows Arch. 2003 May;442(5):429-36 [12684770] Mol Cell Biol. 2004 Jul;24(13):5757-66 [15199132] Cancer Res. 1978 Mar;38(3):624-34 [626967] Br J Cancer. 1988 Jul;58(1):8-12 [3048354] Environ Health Perspect. 1991 Jun;93:133-44 [1685442] Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43 [1540387] Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2759-63 [1557382] Environ Health Perspect. 1996 May;104 Suppl 3:435-9 [8781359] J Cancer Res Clin Oncol. 1997;123(7):365-9 [9260587] Oncogene. 1999 May 27;18(21):3205-12 [10359526] Environ Sci Technol. 2005 Mar 1;39(5):106A-112A [15787356] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] Toxicol In Vitro. 2006 Oct;20(7):1202-12 [16697548] J Pharmacol Exp Ther. 2007 Apr;321(1):202-12 [17204746] Toxicol In Vitro. 2007 Apr;21(3):438-48 [17125965] Oncogene. 2007 Apr 19;26(18):2658-66 [17057737] Environ Health Perspect. 2007 Aug;115(8):1125-31 [17687437] Toxicol Appl Pharmacol. 2007 Dec 1;225(2):162-70 [17945324] Mol Cancer. 2007;6:61 [17894897] Nat Rev Cancer. 2008 Jan;8(1):56-61 [18059462] Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L87-97 [18024722] Nano Lett. 2008 Feb;8(2):437-45 [18225938] J Toxicol Sci. 2008 Feb;33(1):105-16 [18303189] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Environ Health Perspect. 2008 Sep;116(9):1211-7 [18795165] Pharmacol Ther. 2009 Feb;121(2):192-204 [19103221] Toxicol Lett. 2009 May 8;186(3):166-73 [19114091] Environ Mol Mutagen. 2009 Oct;50(8):708-17 [19774611] J Toxicol Environ Health A. 2010;73(5):410-22 [20155582] Cell. 2000 Jan 7;100(1):57-70 [10647931] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nl2011214 ER - TY - CPAPER T1 - FDA Authority and Food Production Controls to Protect the Public from Zoonotic Diseases T2 - 2011 Joint Annual Meeting of the American Dairy Science Association and the American Society for Animal Science (ADSA - ASAS 2011) AN - 1312975837; 6052975 JF - 2011 Joint Annual Meeting of the American Dairy Science Association and the American Society for Animal Science (ADSA - ASAS 2011) AU - Schell, T Y1 - 2011/07/10/ PY - 2011 DA - 2011 Jul 10 KW - Food production KW - FDA KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+for+Animal+Science+%28ADSA+-+ASAS+2011%29&rft.atitle=FDA+Authority+and+Food+Production+Controls+to+Protect+the+Public+from+Zoonotic+Diseases&rft.au=Schell%2C+T&rft.aulast=Schell&rft.aufirst=T&rft.date=2011-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+for+Animal+Science+%28ADSA+-+ASAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2011/pdf/SciProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Advancing mastitis research: Using proteomics to identify biomarkers and evaluate adjunctive therapies T2 - 2011 Joint Annual Meeting of the American Dairy Science Association and the American Society for Animal Science (ADSA - ASAS 2011) AN - 1312959444; 6053104 JF - 2011 Joint Annual Meeting of the American Dairy Science Association and the American Society for Animal Science (ADSA - ASAS 2011) AU - Boehmer, J Y1 - 2011/07/10/ PY - 2011 DA - 2011 Jul 10 KW - Bioindicators KW - Mastitis KW - proteomics KW - biomarkers KW - Therapy KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+for+Animal+Science+%28ADSA+-+ASAS+2011%29&rft.atitle=Advancing+mastitis+research%3A+Using+proteomics+to+identify+biomarkers+and+evaluate+adjunctive+therapies&rft.au=Boehmer%2C+J&rft.aulast=Boehmer&rft.aufirst=J&rft.date=2011-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association+and+the+American+Society+for+Animal+Science+%28ADSA+-+ASAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2011/pdf/SciProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice. AN - 870550431; 21513782 AB - Epidemiological studies suggest that welding, a process which generates an aerosol of inhalable gases and metal rich particulates, increases the risk for cardiovascular disease. In this study we analyzed systemic inflammation and atherosclerotic lesions following gas metal arc-stainless steel (GMA-SS) welding fume exposure. Apolipoprotein E knockout (apoE(-/-)) mice, fed a Western diet, were exposed to GMA-SS at 40mg/m(3) for 3h/day for ten days (∼8.26μg daily alveolar deposition). Mice were sacrificed two weeks after exposure and serum chemistry, serum protein profiling and aortic lesion area were determined. There were no significant changes in serum total cholesterol, triglycerides or alanine aminotransferase. Serum levels of uric acid, a potent antioxidant, were decreased perhaps suggesting a reduced capacity to combat systemic oxidative stress. Inflammatory serum proteins interleukin 1 beta (IL-1β) and monocyte chemoattractant protein 3 (MCP-3) were increased two weeks after GMA-SS exposure. Analysis of atherosclerotic plaques showed an increase in lesion area as the result of GMA-SS exposure. In conclusion, GMA-SS exposure showed evidence of systemic inflammation and increased plaque progression in apoE(-/-) mice. These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Erdely, Aaron AU - Hulderman, Tracy AU - Salmen-Muniz, Rebecca AU - Liston, Angie AU - Zeidler-Erdely, Patti C AU - Chen, Bean T AU - Stone, Samuel AU - Frazer, David G AU - Antonini, James M AU - Simeonova, Petia P AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, United States. Y1 - 2011/07/04/ PY - 2011 DA - 2011 Jul 04 SP - 12 EP - 16 VL - 204 IS - 1 KW - Air Pollutants, Occupational KW - 0 KW - Apolipoproteins E KW - Ccl7 protein, mouse KW - Chemokine CCL7 KW - Interleukin-1beta KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Animals KW - Interleukin-1beta -- blood KW - Inhalation Exposure KW - Air Pollutants, Occupational -- adverse effects KW - Oxidative Stress -- drug effects KW - Mice, Inbred C57BL KW - Lung -- drug effects KW - Chemokine CCL7 -- blood KW - Stainless Steel -- pharmacology KW - Mice KW - Mice, Knockout KW - Apolipoproteins E -- physiology KW - Welding KW - Atherosclerosis -- chemically induced KW - Apolipoproteins E -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870550431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Inhalation+exposure+of+gas-metal+arc+stainless+steel+welding+fume+increased+atherosclerotic+lesions+in+apolipoprotein+E+knockout+mice.&rft.au=Erdely%2C+Aaron%3BHulderman%2C+Tracy%3BSalmen-Muniz%2C+Rebecca%3BListon%2C+Angie%3BZeidler-Erdely%2C+Patti+C%3BChen%2C+Bean+T%3BStone%2C+Samuel%3BFrazer%2C+David+G%3BAntonini%2C+James+M%3BSimeonova%2C+Petia+P&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2011-07-04&rft.volume=204&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2011.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2011-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2011.03.030 ER - TY - JOUR T1 - Occupational Lung Disease Risk and Exposure to Butter-Flavoring Chemicals After Implementation of Controls at a Microwave Popcorn Plant AN - 925720412; 2011-170033 AB - Objectives. After an outbreak of severe lung disease among workers exposed to butter-flavoring chemicals at a microwave popcorn plant, we determined whether or not lung disease risk declined after implementation of exposure controls. Methods. National Institute for Occupational Safety and Health staff performed eight serial cross-sectional medical and industrial hygiene surveys at the plant from November 2000 through August 2003. Medical surveys included standardized questionnaires and spirometry testing. Industrial hygiene surveys measured levels of production-related air contaminants, including butter-flavoring chemicals such as diacetyl. All diacetyl concentrations above detectable limits were corrected for the effects of absolute humidity and days to sample extraction. Results. Ventilation and isolation of the production process resulted in one to three orders of magnitude reductions in diacetyl air concentrations in different areas of the plant. Workers with past high exposures had stable chest symptoms over time; nasal, eye, and skin irritation symptoms declined. New workers had lower symptom prevalences and higher lung function than workers with past high exposures, and they did not worsen over time. In workers who had least three spirometry tests, those with past high exposures were more likely experience rapid declines in lung function than new workers. Conclusions. Implemented controls lowered exposures to butter-flavoring chemicals and decreased lung disease risk for much of the plant workforce. Some workers with continuing potential for intermittent, short-term peak and measurable time-weighted exposures remain at risk and should use respiratory protection and have regularly scheduled spirometry to detect rapid lung function declines that may be work-related. Close follow-up of such workers is likely to yield additional information on risks due to peak and time-weighted exposure levels. Adapted from the source document. JF - Public Health Reports AU - Kanwal, Richard AU - Kullman, Greg AU - Fedan, Kathleen B AU - Kreiss, Kathleen AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., MS H-2800, Morgantown, WV 26505; tel. 304-285-5800; fax 304-285-5820 Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 480 EP - 494 PB - Association of Schools of Public Health, Washington DC VL - 126 IS - 4 SN - 0033-3549, 0033-3549 KW - Social conditions and policy - Public safety and security KW - Health conditions and policy - Diseases and disorders KW - Labor conditions and policy - Occupational health and safety KW - Education and education policy - Statistics, research, research methods, and research support KW - Education and education policy - Information services and sources KW - Social conditions and policy - Social research KW - Manufacturing and heavy industry - Industrial management, production, and productivity KW - Information KW - Industrial hygiene KW - Chemicals KW - Risk KW - Questionnaires KW - Production KW - Lung diseases KW - Surveys KW - Health surveys KW - Testing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925720412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Occupational+Lung+Disease+Risk+and+Exposure+to+Butter-Flavoring+Chemicals+After+Implementation+of+Controls+at+a+Microwave+Popcorn+Plant&rft.au=Kanwal%2C+Richard%3BKullman%2C+Greg%3BFedan%2C+Kathleen+B%3BKreiss%2C+Kathleen&rft.aulast=Kanwal&rft.aufirst=Richard&rft.date=2011-07-01&rft.volume=126&rft.issue=4&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Risk; Chemicals; Lung diseases; Industrial hygiene; Surveys; Information; Testing; Health surveys; Questionnaires; Production ER - TY - JOUR T1 - Managing Multiple Chronic Conditions: A Strategic Framework for Improving Health Outcomes and Quality of Life AN - 925720406; 2011-170032 AB - The escalating problem of multiple chronic conditions (MCC) among Americans is now a major public health and medical challenge, associated with suboptimal health outcomes and rising health-care expenses. Despite this problem's growth, the delivery of health services has continued to employ outmoded "siloed" approaches that focus on individual chronic diseases. We describe an action-oriented framework -- developed by the U.S. Department of Health and Human Services with additional input provided by stakeholder organizations -- that outlines national strategies for maximizing care coordination and for improving health and quality of life for individuals with MCC. We note how the framework's potential can be optimized through some of the provisions of the new Patient Protection and Affordable Care Act, and through public-private partnerships. Adapted from the source document. JF - Public Health Reports AU - Parekh, Anand K AU - Goodman, Richard A AU - Gordon, Catherine AU - Koh, Howard K AD - Department of Health and Human Services, Office of the Assistant Secretary for Health, 200 Independence Ave. SW, Washington, DC 20201; tel. 202-260-2873; fax 202-205-2l07 anand.parekh@hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 460 EP - 471 PB - Association of Schools of Public Health, Washington DC VL - 126 IS - 4 SN - 0033-3549, 0033-3549 KW - Social conditions and policy - Social conditions and problems KW - Economic conditions and policy - Economic conditions KW - Health conditions and policy - Health and health policy KW - Business and service sector - Business organization and administration KW - Government - Public administration KW - Health conditions and policy - Medicine and health care KW - Business and service sector - Insurance KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Diseases and disorders KW - Partnership KW - Public-private sector cooperation KW - Health insurance KW - Patients KW - Diseases KW - Medical service KW - Legislation KW - Public health KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925720406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Managing+Multiple+Chronic+Conditions%3A+A+Strategic+Framework+for+Improving+Health+Outcomes+and+Quality+of+Life&rft.au=Parekh%2C+Anand+K%3BGoodman%2C+Richard+A%3BGordon%2C+Catherine%3BKoh%2C+Howard+K&rft.aulast=Parekh&rft.aufirst=Anand&rft.date=2011-07-01&rft.volume=126&rft.issue=4&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Quality of life; Public health; Public-private sector cooperation; Medical service; Health insurance; Partnership; Legislation; Diseases; Patients ER - TY - JOUR T1 - ANSI/HPS N13.8 UPDATE: AN OPPORTUNITY TO ADVANCE RADIOACTIVE AIR SAMPLING METHODS FOR RADIATION PROTECTION IN URANIUM MINES AN - 920791659; 15691941 AB - The American National Standard for Radiation Protection in Uranium Mines (ANSI N13.8-1973) provides guidance for preventing the overexposure of uranium miners and other workers in the mining and processing of uranium to whole-body external radiation and to ionizing radiation to the lining of the respiratory system. The standard is currently withdrawn, but under revision. The existing scope of the standard is limited to measurement and control of ionizing radiation in uranium mines, but attention is drawn to other deleterious agents that may be present, including silica dust, toxic metals other than uranium, blasting powder gases, diesel exhaust gases, and oxygen-deficient atmospheres. The guidance on radiation protection and radiation exposure measurements is relevant to workers exposed to radon and radon progeny in any situation. Updating this standard is necessary because this standard is widely used by industry and referenced by regulations. Revision of the standard provides the opportunity to update the historically recommended Kusnetz sampling method for measuring potential alpha energy concentrations for exposure to radon progeny, in favor of more contemporary methods involving either periodic filter sampling with more accurate options for subsequent multiple counting intervals, or with more explicit guidance for use of realtime alpha air monitoring using spectroscopy. Some exposure situations involving high concentrations of freshly released radon without sufficient time for establishment of equilibrium (such as from water outfalls) may warrant direct measurement or better estimation of radon concentration itself, rather than decay progeny only. The revision will include guidance regarding the frequency of sample collection under changing operational and environmental conditions and the frequency of recalibration. The revision committee is also considering the removal of a specific annual dose limit from the standard in favor of guidance that advises users to refer to their governing regulatory authority. JF - Health Physics AU - Hoover, M AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - S54 EP - S55 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 101 IS - 1 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Powder KW - Heavy metals KW - Spectroscopy KW - Dust KW - Workers KW - Uranium KW - Air sampling KW - Sampling KW - Occupational exposure KW - Mines KW - Radon KW - Exhausts KW - Gases KW - Silica KW - Energy KW - Ionizing radiation KW - Radiation measurements KW - Diesel KW - Progeny KW - Mining KW - Environmental conditions KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920791659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=ANSI%2FHPS+N13.8+UPDATE%3A+AN+OPPORTUNITY+TO+ADVANCE+RADIOACTIVE+AIR+SAMPLING+METHODS+FOR+RADIATION+PROTECTION+IN+URANIUM+MINES&rft.au=Hoover%2C+M&rft.aulast=Hoover&rft.aufirst=M&rft.date=2011-07-01&rft.volume=101&rft.issue=1&rft.spage=S54&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Powder; Heavy metals; Spectroscopy; Mines; Dust; Radon; Exhausts; Workers; Silica; Gases; Uranium; Ionizing radiation; Energy; Progeny; Diesel; Mining; Sampling; Environmental conditions; Occupational exposure; Air sampling; Radiation measurements ER - TY - JOUR T1 - Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases AN - 915486573; 16101638 AB - Facing substantial obstacles to developing new therapies for rare diseases, some sponsors are looking to 'repurpose' drugs already approved for other conditions and use those therapies to treat rare diseases. In an effort to facilitate such repurposing and speed the delivery of new therapies to people who need them, we have established a new resource, the Rare Disease Repurposing Database (RDRD). The advantages of repurposed compounds include their demonstrated efficacy (in some clinical contexts), their observed toxicity profiles and their clearly described manufacturing controls. To create the RDRD, we matched the US Food and Drug Administration (FDA) orphan designation database to FDA drug and biological product approval lists. The RDRD lists 236 products that have received orphan status designation-that is, were found to be 'promising' for the treatment of a rare disease-and though not yet approved for marketing for that rare disease, they are already approved for marketing to treat some other disease or condition. The RDRD contains three tables: Orphan-designated products with at least one marketing approval for a common disease indication (N = 109); orphan-designated products with at least one marketing approval for a rare disease indication (N = 76); and orphan-designated products with marketing approvals for both common and rare disease indications (N = 51). While the data included in the database is a re-configuration/cross-indexing of information already released by the FDA, it offers sponsors a new tool for finding special opportunities to develop niche therapies for rare disease patients. JF - Briefings in Bioinformatics AU - Xu, Kui AU - Cote, Timothy R Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 341 EP - 345 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 12 IS - 4 SN - 1467-5463, 1467-5463 KW - Biotechnology and Bioengineering Abstracts KW - orphan drug KW - rare disease KW - repurposing KW - Orphan Drug Act KW - efficacy KW - safety KW - Databases KW - Data processing KW - Niches KW - Toxicity KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915486573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Briefings+in+Bioinformatics&rft.atitle=Database+identifies+FDA-approved+drugs+with+potential+to+be+repurposed+for+treatment+of+orphan+diseases&rft.au=Xu%2C+Kui%3BCote%2C+Timothy+R&rft.aulast=Xu&rft.aufirst=Kui&rft.date=2011-07-01&rft.volume=12&rft.issue=4&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Briefings+in+Bioinformatics&rft.issn=14675463&rft_id=info:doi/10.1093%2Fbib%2Fbbr006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Niches; Bioinformatics; Toxicity DO - http://dx.doi.org/10.1093/bib/bbr006 ER - TY - JOUR T1 - Sources and fate of chiral organochlorine pesticides in Western U.S. national park ecosystems AN - 907922928; 2012-000593 JF - Environmental Toxicology and Chemistry AU - Genualdi, Susan A AU - Hageman, Kimberly J AU - Ackerman, Luke K AU - Usenko, Sascha AU - Simonich, Staci L Massey Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 1533 EP - 1538 PB - Wiley InterScience on behalf of SETAC (Society of Environmental Toxicology and Chemistry), Pensacola, FL VL - 30 IS - 7 SN - 0730-7268, 0730-7268 KW - United States KW - chlorinated hydrocarbons KW - rivers and streams KW - national parks KW - organochlorine pesticides KW - ecosystems KW - California KW - Oregon KW - snowpack KW - Western U.S. KW - halogenated hydrocarbons KW - soils KW - North America KW - concentration KW - Washington KW - pollution KW - public lands KW - organic compounds KW - lacustrine environment KW - chlordane KW - Alaska KW - transformations KW - pesticides KW - aquatic environment KW - Rocky Mountains KW - land use KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907922928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Sources+and+fate+of+chiral+organochlorine+pesticides+in+Western+U.S.+national+park+ecosystems&rft.au=Genualdi%2C+Susan+A%3BHageman%2C+Kimberly+J%3BAckerman%2C+Luke+K%3BUsenko%2C+Sascha%3BSimonich%2C+Staci+L+Massey&rft.aulast=Genualdi&rft.aufirst=Susan&rft.date=2011-07-01&rft.volume=30&rft.issue=7&rft.spage=1533&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1002%2Fetc.538 L2 - http://www3.interscience.wiley.com/journal/122563640/home?CRETRY=1&SRETRY=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2012-01-01 N1 - Number of references - 38 N1 - PubXState - FL N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Alaska; aquatic environment; California; chlordane; chlorinated hydrocarbons; concentration; ecosystems; halogenated hydrocarbons; lacustrine environment; land use; national parks; North America; Oregon; organic compounds; organochlorine pesticides; pesticides; pollution; public lands; rivers and streams; Rocky Mountains; snowpack; soils; transformations; United States; Washington; Western U.S. DO - http://dx.doi.org/10.1002/etc.538 ER - TY - JOUR T1 - MAPREC assay for quantitation of mutants in a recombinant flavivirus vaccine strain using near-infrared fluorescent dyes AN - 907179398; 15160225 AB - The assay is highly sensitive and reliable but requires radioactive isotopes, which complicates its use in quality control laboratories. To quantify mutants in the cDNA of the West Nile (WN)/Dengue 4 chimera that was proposed as a new candidate of live vaccine against West Nile disease, alternative MAPREC protocols using non-radioactive dyes were explored. To compare the utility of different fluorescent dyes for MAPREC, the G2337 a'C mutation that was revealed by microarray hybridization in WN/Dengue 4 chimera virus was used as a model. DNA fragments produced by restriction endonuclease digestion were visualized in polyacrylamide gels by visible-range fluorescent dyes including ethidium bromide (EtBr) and SYBR Green I as well as by near-infrared (NIR) dye SYTO 60 and NIR dyes 700 and 800. The MAPREC assay performed with SYTO 60 and SYBR Green I was more sensitive than with EtBr but less sensitive than with NIR dyes 700 or 800. The NIR dyes 700 and 800 exhibited a wide linear range that may enable the detection of 0.05% of mutants in viral stocks. The NIR-based MAPREC assay was validated by using World Health Organization (WHO) international references for poliovirus type 3 with known contents of mutants. Values of mutant content produced by the non-radioactive assay were similar to the values determined in a previous WHO international collaborative study. The modified MAPREC assay could be used as an alternative to the radioisotope-based standard protocol for quality control of live viral vaccines. JF - Journal of Virological Methods AU - Bidzhieva, Bella AU - Laassri, Majid AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA, konstantin.chumakov@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 14 EP - 19 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 175 IS - 1 SN - 0166-0934, 0166-0934 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts KW - West Nile/Dengue 4 chimera KW - Oral polio vaccine KW - Non-radioactive KW - Quantitative method KW - Vaccine safety KW - Genetic stability KW - Isotopes KW - Human diseases KW - Disease control KW - Flavivirus KW - Models KW - Public health KW - Gels KW - Dengue KW - Fluorescent indicators KW - Disease detection KW - Endonuclease KW - Quantitation KW - Poliovirus KW - I.R. radiation KW - Mutations KW - Recombinants KW - Chimeras KW - Dyes KW - Quality control KW - DNA KW - Ethidium bromide KW - Vaccines KW - Mutation KW - V 22300:Methods KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907179398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=MAPREC+assay+for+quantitation+of+mutants+in+a+recombinant+flavivirus+vaccine+strain+using+near-infrared+fluorescent+dyes&rft.au=Bidzhieva%2C+Bella%3BLaassri%2C+Majid%3BChumakov%2C+Konstantin&rft.aulast=Bidzhieva&rft.aufirst=Bella&rft.date=2011-07-01&rft.volume=175&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2011.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Recombinants; Human diseases; Dyes; Mutations; Quality control; Disease control; Disease detection; Vaccines; Public health; Isotopes; I.R. radiation; Models; Gels; Chimeras; Dengue; Ethidium bromide; DNA; Fluorescent indicators; Endonuclease; Mutation; Quantitation; Poliovirus; Flavivirus DO - http://dx.doi.org/10.1016/j.jviromet.2011.04.008 ER - TY - JOUR T1 - Testing the long-term efficacy of a prevention program for improving marital conflict in community families AN - 902097144; 201119349 AB - Family-focused prevention programs for community samples have potentially broad, clinically relevant implications but few studies have examined whether any program benefits continue to be observed over the long term. Although benefits of a marital conflict focused parent education program, the Happy Couples and Happy Kids (i.e., HCHK) program, were supported in a study based on pre-test, post-test, 6-month follow-up, and 1-year follow-up assessments, the longer-term stability of treatment effects has not been established. Couples with children between 4 and 8 years of age who had previously participated in the HCHK study completed a two-year follow-up, including a parent-only group (PO, n = 12); parent-child group (PC, n = 15); and a self-study group (SS, n = 12). Greater knowledge about the effects of marital conflict on families and behavioral improvements in constructive conflict, and specifically in problem-solving behaviors, were observed at the two-year follow-up for couples who received the HCHK program, Reflecting an innovative analysis of mediating mechanisms, change-to-change analyses showed that these changes were linked with improvements in other family processes over time, including marital satisfaction, parenting and child adjustment, The findings support the relatively long-term efficacy of brief, psychoeducational programs for educating community samples about marital conflict and family processes. [Copyright Elsevier Inc.] JF - Journal of Applied Developmental Psychology AU - Faircloth, W Brad AU - Schermerhorn, Alice C AU - Mitchell, Patricia M AU - Cummings, Jennifer S AU - Cummings, E Mark AD - North Carolina Department of Health and Human Services, Family, Infant and Preschool Program, 300 Enola Rd., Morganton, NC 28655. USA. Tel: + 1 828 430 7960; fax: + 1 828 43806457 brad.faircloth@dhhs.nc.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 189 EP - 197 PB - Elsevier Science, Amsterdan The Netherlands VL - 32 IS - 4 SN - 0193-3973, 0193-3973 KW - Prevention, Marital conflict, Child adjustment, Psychoeducation, Parenting KW - Parenting KW - Efficacy KW - Marital conflict KW - Children KW - Educational programmes KW - Preventive programmes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902097144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Developmental+Psychology&rft.atitle=Testing+the+long-term+efficacy+of+a+prevention+program+for+improving+marital+conflict+in+community+families&rft.au=Faircloth%2C+W+Brad%3BSchermerhorn%2C+Alice+C%3BMitchell%2C+Patricia+M%3BCummings%2C+Jennifer+S%3BCummings%2C+E+Mark&rft.aulast=Faircloth&rft.aufirst=W&rft.date=2011-07-01&rft.volume=32&rft.issue=4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Developmental+Psychology&rft.issn=01933973&rft_id=info:doi/10.1016%2Fj.appdev.2011.05.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JADPDS N1 - SubjectsTermNotLitGenreText - Marital conflict; Preventive programmes; Efficacy; Children; Educational programmes; Parenting DO - http://dx.doi.org/10.1016/j.appdev.2011.05.004 ER - TY - JOUR T1 - Advancing the development of diagnostic tests and biomarkers for tuberculosis AN - 899153351; 15220564 AB - High costs and limited returns on investment have hampered progress in developing new diagnostic tests and treatments for tuberculosis (TB). We need new biomarkers to develop assays that can rapidly, efficiently and reliably detect Mycobacterium tuberculosis infection and disease, identify drug resistance and expedite drug and vaccine development. This can only be accomplished through cross-disciplinary collaborations to facilitate access to human specimens. The Food and Drug Administration, Centers for Disease Control and Prevention, National Institutes of Health, the industry and academia experts came together in a June 2010 workshop to examine the field of TB diagnostic test development and biomarker discovery, identify areas of most urgent need and formulate strategies to address those needs. JF - International Journal of Tuberculosis and Lung Disease AU - Yasinskaya, Y AU - Plikaytis, B AU - Sizemore, C AU - Sacks, L AD - Office of Chief Scientist, Office of Critical Path Programs, FDA, Rm 4110, Building 32, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA, Yuliya.Yasinskaya@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 985 EP - 987 PB - International Union Against Tuberculosis and Lung Disease VL - 15 IS - 7 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - Conferences KW - Drug resistance KW - Disease control KW - Lung diseases KW - Tuberculosis KW - Drug development KW - Vaccines KW - Infection KW - biomarkers KW - Mycobacterium tuberculosis KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899153351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Advancing+the+development+of+diagnostic+tests+and+biomarkers+for+tuberculosis&rft.au=Yasinskaya%2C+Y%3BPlikaytis%2C+B%3BSizemore%2C+C%3BSacks%2C+L&rft.aulast=Yasinskaya&rft.aufirst=Y&rft.date=2011-07-01&rft.volume=15&rft.issue=7&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.10.0712 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Conferences; Drug resistance; Lung diseases; Disease control; Drug development; Tuberculosis; Vaccines; Infection; biomarkers; Mycobacterium tuberculosis DO - http://dx.doi.org/10.5588/ijtld.10.0712 ER - TY - JOUR T1 - Farmwork-Related Injury Among Farmers 50 Years of Age and Older in Kentucky and South Carolina: A Cohort Study, 2002-2005 AN - 899149057; 15695829 AB - Farmers in the U.S. are becoming more diverse; the average age of the farmer is increasing, as is the number of women and minority farm operators. There is limited research on injury risk factors in these special populations of farmers. It is especially important to study the risk factors for injury in these growing and at-risk groups. A longitudinal survey was conducted of farmers (n = 1,394) age 50 and older who resided in Kentucky and South Carolina. The questionnaire was administered by telephone and mail surveys four times between 2002 and 2005 to the fixed cohort of farmers, obtained by convenience sample. Approximately half of the cohort was female, and the majority of the cohort worked less than 40 hours per week. This cohort reported a crude, non-fatal injury rate of 9.3 injured farmers per 100 per year. Farmers reporting chronic bronchitis/emphysema (estimated odds ratio [EOR] = 1.57), back problems (EOR = 1.37), arthritis (EOR = 1.31), 3 to 4 restless nights in the past week (EOR = 2.02), or 5 to 7 restless nights in the past week (EOR = 1.82) were at significantly higher odds of sustaining a farmwork-related injury as calculated by the generalized estimating equations (GEE) regression method. Farmers operating equipment on highways (EOR = 1.51) or climbing higher than eight feet (EOR = 1.69) were at significantly higher odds of sustaining a farmwork-related injury, and females were at higher risk of injury when performing animal-related tasks (EOR = 3.00) or crop-related tasks (EOR = 2.21). Identified factors associated with farmwork-related injury should better inform agricultural health policies and guidelines for older farmers, such as policies governing the allowable number of hours worked per week and rest breaks, guidelines that advise appropriate types of farm tasks, and ergonomic engineering advances on farming equipment. JF - Journal of Agricultural Safety and Health AU - Marcum, J L AU - Browning AU - Reed, D B AU - Charnigo, R J AD - Department of Health and Human Services, Division of Public Health, 301 Centennial Mall South, Lincoln, NE 68509, USA, Jennifer.Marcum@Nebraska.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 259 EP - 273 VL - 17 IS - 3 SN - 1074-7583, 1074-7583 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - USA, South Carolina KW - USA, Kentucky KW - Injuries KW - guidelines KW - Risk factors KW - farms KW - agriculture KW - health policy KW - Highways KW - Ergonomics KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899149057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Farmwork-Related+Injury+Among+Farmers+50+Years+of+Age+and+Older+in+Kentucky+and+South+Carolina%3A+A+Cohort+Study%2C+2002-2005&rft.au=Marcum%2C+J+L%3BBrowning%3BReed%2C+D+B%3BCharnigo%2C+R+J&rft.aulast=Marcum&rft.aufirst=J&rft.date=2011-07-01&rft.volume=17&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Age; Injuries; guidelines; farms; Risk factors; agriculture; health policy; Highways; Ergonomics; USA, South Carolina; USA, Kentucky ER - TY - JOUR T1 - The Epidemiology of Fatal Occupational Traumatic Brain Injury in the U.S AN - 896169043; 201118378 AB - Background: Although traumatic brain injury (TBI) is one of the leading causes of death and disability in the U.S., work-related TBI has not been well documented. Purpose: The aim of this study was to describe the epidemiologic characteristics and temporal trends of fatal occupational TBI in the U.S between 2003 and 2008. Methods: A cross-sectional analysis of the Census of Fatal Occupational Injury database was performed. Both the Occupational Injury and Illness Classification System nature of injury codes and body part codes were used to define TBIs. Fatality rates were calculated using denominators derived from the Current Population Survey. Fatality rates were compared among industries, cause of death, and demographics with rate ratios (RRs) and 95% CIs. Poisson regression was used to assess trends in fatality rates. Data were analyzed in 2009-2010. Results: Nearly 7300 occupational TBI deaths occurred between 2003 and 2008, for an average fatality rate of 0.8 per 100,000 workers per year. The leading causes of occupational TBI death were as follows: motor vehicle (31%); falls (29%); assaults and violent acts (20%); and contact with objects/equipment (18%). Fatality rates were 15 times higher in men compared with women (RR=15, 95% CI=13.7, 16.3). Workers aged =65 years experienced the highest TBI fatality rate of all age groups (2.5 per 100,000 per year). Construction, transportation, and agriculture/forestry/fishing industries recorded nearly half of all TBI fatalities (n=1828, n=825, n=761, respectively). Occupational TBI death rates declined 23% over the 6-year period (p0.0001). Conclusions: This study provides the first national profile of fatal TBIs occurring in the U.S. workplace. Prevention efforts should be directed at those industries with the highest frequency and/or highest risk. The construction industry had the highest number of TBIs, and the agriculture, forestry, and fishing industry had the highest rates. Additionally, workers aged 65 years in all industries would be a good target for future prevention efforts. [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Tiesman, Hope M AU - Konda, Srinivas AU - Bell, Jennifer L AD - National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, West Virginia htiesman@cdc.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 61 EP - 67 PB - Elsevier Science, New York NY VL - 41 IS - 1 SN - 0749-3797, 0749-3797 KW - Agriculture KW - Death KW - Traumatic brain injury KW - Preventive programmes KW - Construction industry KW - Forestry KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896169043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Epidemiology+of+Fatal+Occupational+Traumatic+Brain+Injury+in+the+U.S&rft.au=Tiesman%2C+Hope+M%3BKonda%2C+Srinivas%3BBell%2C+Jennifer+L&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2011-07-01&rft.volume=41&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2011.03.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Death; Construction industry; Forestry; Preventive programmes; Traumatic brain injury; Agriculture DO - http://dx.doi.org/10.1016/j.amepre.2011.03.007 ER - TY - JOUR T1 - Subjective perceptions and ergonomics evaluation of a liquid cooled garment worn under protective ensemble during an intermittent treadmill exercise AN - 888110758; 15524483 AB - While a personal protective equipment (PPE) ensemble effectively provides workers with protection from occupational hazards, working in a vapour-resistant ensemble increases the risk of heat illness/injuries and physiological burdens. The purpose of this study was to investigate the effect of body cooling via a liquid-cooled garment (LCG) underneath a PPE ensemble on perceived thermal strain, physiological responses and ergonomics during an intermittent treadmill exercise in warm environmental conditions. The results of the present study indicated that the concomitant wearing of LCG underneath the PPE ensemble significantly reduced subjective perception of heat and alleviated overall increase in body temperature and heart rate while no impact of wearing LCG on ergonomic features was found. The extension of the present findings to practical applications in occupational settings requires further research on a LCG system design and performance evaluations while the LCG is incorporated within the PPE ensemble. Statement of Relevance: Implementation of a LCG underneath PPE for body cooling was investigated, focusing on its impact on individuals' perceived thermal strain, physiological responses and ergonomics. The findings of the present study indicated that body cooling via a wearable LCG underneath PPE significantly alleviated both perceived thermal and physiological strain in uncompensable heat stress condition. JF - Ergonomics AU - Kim, Jung-Hyun AU - Coca, Aitor AU - Williams, WJon AU - Roberge, Raymond J AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Pittsburgh, PA, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 626 EP - 635 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 54 IS - 7 SN - 0014-0139, 0014-0139 KW - Physical Education Index; Risk Abstracts; Health & Safety Science Abstracts KW - ergonomics KW - liquid-cooled garment KW - protective ensemble KW - subjective perceptions KW - heat tolerance KW - Exercise (duration) KW - Physiology KW - Strains KW - Protective equipment KW - Evaluation KW - Vapors KW - heart rate KW - Perception KW - Heat KW - Physiological responses KW - Environmental conditions KW - Ergonomics KW - Treadmill ergometry KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888110758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Subjective+perceptions+and+ergonomics+evaluation+of+a+liquid+cooled+garment+worn+under+protective+ensemble+during+an+intermittent+treadmill+exercise&rft.au=Kim%2C+Jung-Hyun%3BCoca%2C+Aitor%3BWilliams%2C+WJon%3BRoberge%2C+Raymond+J&rft.aulast=Kim&rft.aufirst=Jung-Hyun&rft.date=2011-07-01&rft.volume=54&rft.issue=7&rft.spage=626&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2011.583362 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Evaluation; Exercise (duration); Heat; Perception; Physiological responses; Physiology; Strains; Treadmill ergometry; Ergonomics; heat tolerance; Vapors; heart rate; Environmental conditions; Protective equipment DO - http://dx.doi.org/10.1080/00140139.2011.583362 ER - TY - JOUR T1 - Occupational sensitization to soy allergens in workers at a processing facility AN - 883025496; 15211845 AB - Background Exposure to soy antigens has been associated with asthma in community outbreaks and in some workplaces. Recently, 135 soy flake processing workers (SPWs) in a Tennessee facility were evaluated for immune reactivity to soy. Allergic sensitization to soy was common and was five times more prevalent than in health care worker controls (HCWs) with no known soy exposure. Objective To characterize sensitization to soy allergens in SPWs. Methods Sera that were positive to soy ImmunoCAP (n=27) were tested in IgE immunoblots. Wild-type (WT) and transgenic (TG) antigens were sequenced using nanoscale Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry (nanoUPLC MS/MS). IgE reactivity towards 5-enolpyruvylshikimate-3-phosphate synthase (CP4-EPSP), a protein found in TG soy, was additionally investigated. De-identified sera from 50 HCWs were used as a control. Results Immunoblotting of WT and TG soy flake extracts revealed IgE against multiple soy antigens with reactivity towards 48, 54, and 62kDa bands being the most common. The prominent proteins that bound SPW IgE were identified by nanoUPLC MS/MS analysis to be the high molecular weight soybean storage proteins, beta -conglycinin (Gly m 5), and Glycinin (Gly m 6). No specific IgE reactivity could be detected to lower molecular weight soy allergens, Gly m 1 and Gly m 2, in soybean hull (SH) extracts. IgE reactivity was comparable between WT and TG extracts; however, IgE antibodies to CP4-EPSP could not be detected. Conclusions and Clinical Relevance SPWs with specific IgE to soy reacted most commonly with higher molecular weight soybean storage proteins compared with the lower molecular weight SH allergens identified in community asthma studies. IgE reactivity was comparable between WT and TG soy extracts, while no IgE reactivity to CP4-EPSP was observed. High molecular weight soybean storage allergens, Gly m 5 and Gly m 6, may be respiratory sensitizers in occupational exposed SPWs. Cite this as: B. J. Green, K. J. Cummings, W. R. Rittenour, J. M. Hettick, T. A. Bledsoe, F. M.Blachere, P. D. Siegel, D. M. Gaughan, G. J. Kullman, K. Kreiss, J. Cox-Ganser and D. H. Beezhold, Clinical & Experimental Allergy, 2011 (41) 1022-1030. JF - Clinical and Experimental Allergy AU - Green, B J AU - Cummings, K J AU - Rittenour, W R AU - Hettick, J M AU - Bledsoe, T A AU - Blachere, F M AU - Siegel, P D AU - Gaughan, D M AU - Kullman, G J AU - Kreiss, K AU - Cox-Ganser, J AU - Beezhold, D H AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1022 EP - 1030 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 41 IS - 7 SN - 0954-7894, 0954-7894 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - Allergens KW - Allergies KW - Asthma KW - Hypersensitivity KW - Immunoblotting KW - Immunoglobulin E KW - Liquid chromatography KW - Mass spectroscopy KW - Medical personnel KW - Molecular weight KW - Occupational exposure KW - Proteins KW - Respiratory diseases KW - Soybeans KW - Storage KW - Workers KW - storage proteins KW - USA, Tennessee KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883025496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Experimental+Allergy&rft.atitle=Occupational+sensitization+to+soy+allergens+in+workers+at+a+processing+facility&rft.au=Green%2C+B+J%3BCummings%2C+K+J%3BRittenour%2C+W+R%3BHettick%2C+J+M%3BBledsoe%2C+T+A%3BBlachere%2C+F+M%3BSiegel%2C+P+D%3BGaughan%2C+D+M%3BKullman%2C+G+J%3BKreiss%2C+K%3BCox-Ganser%2C+J%3BBeezhold%2C+D+H&rft.aulast=Green&rft.aufirst=B&rft.date=2011-07-01&rft.volume=41&rft.issue=7&rft.spage=1022&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Experimental+Allergy&rft.issn=09547894&rft_id=info:doi/10.1111%2Fj.1365-2222.2011.03756.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Document feature - figure 4 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Asthma; storage proteins; Mass spectroscopy; Medical personnel; Soybeans; Workers; Hypersensitivity; Liquid chromatography; Immunoglobulin E; Allergens; Molecular weight; Occupational exposure; Storage; Proteins; Respiratory diseases; Allergies; USA, Tennessee DO - http://dx.doi.org/10.1111/j.1365-2222.2011.03756.x ER - TY - JOUR T1 - Bioavailability Considerations in Evaluating Drug-Drug Interactions Using the Population Pharmacokinetic Approach AN - 876247889; 15070636 AB - Applying a comedication (COMD) covariate to apparent clearance (CLapp = CL/F) is a common practice when using population pharmacokinetics (PopPK) to study metabolism-based drug-drug interactions (DDI). This study evaluates the importance of independently applying COMD to F and CL to account for DDI at the level of first-pass metabolism. A known DDI between single oral doses of the CYP3A substrate midazolam (5 mg) and the inhibitor ketoconazole (400 mg) was simulated using a physiologically based pharmacokinetic simulator SimCyp in virtual subjects. The simulated midazolam data were analyzed by PopPK method under the following scenarios by applying COMD effect to (1) CLapp only, (2) CL and F, and (3) CLapp and apparent volume of distribution (Vapp = V/F), assuming V is unchanged. The mean simulated degree of interaction, measured by midazolam AUC ratio with and without ketoconazole (AUCR), was 10.28. Scenario 1 underestimated AUCR. When COMD was independently applied to F and Vapp in scenarios 2 and 3, lower objective function values of the PopPK analysis and more accurate AUCR estimates were achieved. AUCR estimates were also dependent on sampling. The authors conclude that when significant inhibition of the first-pass metabolism of the substrate is anticipated, COMD effects should be applied to both CL and F in PopPK analysis. JF - Journal of Clinical Pharmacology AU - Duan, John Z AU - Jackson, Andre J AU - Zhao, Ping AD -  , john.duan@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 1087 EP - 1100 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 51 IS - 7 SN - 0091-2700, 0091-2700 KW - Health & Safety Science Abstracts KW - Bioavailability KW - Physiology KW - Pharmacokinetics KW - Metabolism KW - drug interaction KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876247889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Bioavailability+Considerations+in+Evaluating+Drug-Drug+Interactions+Using+the+Population+Pharmacokinetic+Approach&rft.au=Duan%2C+John+Z%3BJackson%2C+Andre+J%3BZhao%2C+Ping&rft.aulast=Duan&rft.aufirst=John&rft.date=2011-07-01&rft.volume=51&rft.issue=7&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270010377200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioavailability; Physiology; drug interaction; Metabolism; Pharmacokinetics DO - http://dx.doi.org/10.1177/0091270010377200 ER - TY - JOUR T1 - Current status of genome-wide association studies in cancer. AN - 874482744; 21678065 AB - Genome-wide association studies in cancer have already identified over 150 regions associated with two dozen specific cancers. Already, a handful of multi-cancer susceptibility regions have been uncovered, providing new insights into perhaps common mechanisms of carcinogenesis. For each new susceptibility allele, investigators now face the arduous task of interrogating each region beginning with fine mapping prior to pursuing the biological basis for the direct association of one or more variants. It appears that there may be a significant number of common alleles that contribute to the heritability of a specific cancer. Since each region confers a small contribution to the risk for cancer, it is daunting to consider any single nucleotide polymorphism (SNP) as a clinical test. Since the complex genomic architecture of each cancer differs, additional genotyping and sequence analysis will be required to comprehensively catalog susceptibility alleles followed by the formidable task of understanding the interactions between genetic regions as well as the environment. It will be critical to assess the applicability of genetic tests in specific clinical settings, such as when to perform screening tests with calculable risks (e.g., biopsies or chemoprevention), before incorporating SNPs into clinical practice. To advance the current genomic observations to the clinical venue, new studies will need to be designed to validate the utility of known genetic variants in assessing risk for cancer as well as its outcomes. JF - Human genetics AU - Chung, Charles C AU - Chanock, Stephen J AD - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4608, USA. Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 59 EP - 78 VL - 130 IS - 1 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Humans KW - Genetic Predisposition to Disease KW - Neoplasms -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874482744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+genetics&rft.atitle=Current+status+of+genome-wide+association+studies+in+cancer.&rft.au=Chung%2C+Charles+C%3BChanock%2C+Stephen+J&rft.aulast=Chung&rft.aufirst=Charles&rft.date=2011-07-01&rft.volume=130&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Human+genetics&rft.issn=1432-1203&rft_id=info:doi/10.1007%2Fs00439-011-1030-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-23 N1 - Date created - 2011-07-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00439-011-1030-9 ER - TY - JOUR T1 - Population dynamics of Salmonella enterica serotypes in commercial egg and poultry production. AN - 873704970; 21571882 AB - Fresh and processed poultry have been frequently implicated in cases of human salmonellosis. Furthermore, increased consumption of meat and poultry has increased the potential for exposure to Salmonella enterica. While advances have been made in reducing the prevalence and frequency of Salmonella contamination in processed poultry, there is mounting pressure on commercial growers to prevent and/or eliminate these human pathogens in preharvest production facilities. Several factors contribute to Salmonella colonization in commercial poultry, including the serovar and the infectious dose. In the early 1900s, Salmonella enterica serovars Pullorum and Gallinarum caused widespread diseases in poultry, but vaccination and other voluntary programs helped eradicate pullorum disease and fowl typhoid from commercial flocks. However, the niche created by the eradication of these serovars was likely filled by S. Enteritidis, which proliferated in the bird populations. While this pathogen remains a significant problem in commercial egg and poultry production, its prevalence among poultry has been declining since the 1990s. Coinciding with the decrease of S. Enteritidis, S. Heidelberg and S. Kentucky have emerged as the predominant serovars in commercial broilers. In this review, we have highlighted bacterial genetic and host-related factors that may contribute to such shifts in Salmonella populations in commercial poultry and intervention strategies that could limit their colonization. JF - Applied and environmental microbiology AU - Foley, Steven L AU - Nayak, Rajesh AU - Hanning, Irene B AU - Johnson, Timothy J AU - Han, Jing AU - Ricke, Steven C AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. steven.foley@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 4273 EP - 4279 VL - 77 IS - 13 KW - Index Medicus KW - Animals KW - Population Dynamics KW - Serotyping KW - Salmonella Infections, Animal -- microbiology KW - Salmonella enterica -- isolation & purification KW - Ovum -- microbiology KW - Salmonella enterica -- pathogenicity KW - Salmonella enterica -- genetics KW - Poultry -- microbiology KW - Salmonella enterica -- classification KW - Salmonella Infections, Animal -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/873704970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Population+dynamics+of+Salmonella+enterica+serotypes+in+commercial+egg+and+poultry+production.&rft.au=Foley%2C+Steven+L%3BNayak%2C+Rajesh%3BHanning%2C+Irene+B%3BJohnson%2C+Timothy+J%3BHan%2C+Jing%3BRicke%2C+Steven+C&rft.aulast=Foley&rft.aufirst=Steven&rft.date=2011-07-01&rft.volume=77&rft.issue=13&rft.spage=4273&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00598-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-12 N1 - Date created - 2011-06-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2000 Jun;36(5):997-1005 [10844685] Mol Microbiol. 2000 Jun;36(5):1015-23 [10844687] J Food Prot. 2000 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JOUR T1 - Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish. AN - 869797100; 21461911 AB - The expression of at least some biomarkers of toxicity is generally thought to precede the appearance of frank pathology. In the context of developmental toxicity, certain early indicators may be predictive of later drastic outcome. The search for predictive biomarkers of toxicity in the cells (blastomeres) of an early embryo can benefit from the fact that for normal development to proceed, the maintenance of blastomere cellular integrity during the process of transition from an embryo to a fully functional organism is paramount. Actin microfilaments are integral parts of blastomeres in the developing zebrafish embryo and contribute toward the proper progression of early development (cleavage and epiboly). In early embryos, the filamentous actin (F-actin) is present and helps to define the boundary of each blastomere as they remain adhered to each other. In our studies, we observed that when blastomeric F-actin is depolymerized by agents like gelsolin, the blastomeres lose cellular integrity, which results in abnormal larvae later in development. There are a variety of toxicants that depolymerize F-actin in early mammalian embryos, the later consequences of which are, at present, not known. We propose that very early zebrafish embryos (~5-h old) exposed to such toxicants will also respond in a like manner. In this review, we discuss the potential use of F-actin disruption as a predictive biomarker of developmental toxicity in zebrafish. JF - Molecular and cellular biochemistry AU - Kanungo, Jyotshnabala AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. jyotshnabala.kanungo@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 283 EP - 290 VL - 353 IS - 1-2 KW - Actins KW - 0 KW - Biomarkers KW - Environmental Pollutants KW - Polychlorinated Dibenzodioxins KW - Index Medicus KW - Animals KW - Environmental Pollutants -- toxicity KW - Zebrafish -- metabolism KW - Polychlorinated Dibenzodioxins -- toxicity KW - Zebrafish -- embryology KW - Models, Biological KW - Blastomeres -- drug effects KW - Embryo, Nonmammalian -- embryology KW - Biomarkers -- metabolism KW - Actins -- metabolism KW - Embryo, Nonmammalian -- metabolism KW - Embryo, Nonmammalian -- drug effects KW - Blastomeres -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869797100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Disruption+of+blastomeric+F-actin%3A+a+potential+early+biomarker+of+developmental+toxicity+in+zebrafish.&rft.au=Kanungo%2C+Jyotshnabala%3BPaule%2C+Merle+G&rft.aulast=Kanungo&rft.aufirst=Jyotshnabala&rft.date=2011-07-01&rft.volume=353&rft.issue=1-2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=1573-4919&rft_id=info:doi/10.1007%2Fs11010-011-0797-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-18 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11010-011-0797-2 ER - TY - JOUR T1 - Postural stability effects of random vibration at the feet of construction workers in simulated elevation AN - 869581858; 14767533 AB - The risk of falls from height on a construction site increases under conditions which degrade workers' postural control. At elevation, workers depend heavily on sensory information from their feet to maintain balance. The study tested two hypotheses: "sensory enhancement" - sub-sensory (undetectable) random mechanical vibrations at the plantar surface of the feet can improve worker's balance at elevation; and "sensory suppression" - supra-sensory (detectable) random mechanical vibrations can have a degrading effect on balance in the same experimental settings. Six young (age 20-35) and six aging (age 45-60) construction workers were tested while standing in standard and semi-tandem postures on instrumented gel insoles. The insoles applied sub- or supra-sensory levels of random mechanical vibrations to the feet. The tests were conducted in a surround-screen virtual reality system, which simulated a narrow plank at elevation on a construction site. Upper body kinematics was assessed with a motion-measurement system. Postural stability effects were evaluated by conventional and statistical mechanics sway measures, as well as trunk angular displacement parameters. Analysis of variance did not confirm the "sensory enhancement" hypothesis, but provided evidence for the "sensory suppression" hypothesis. The supra-sensory vibration had a destabilizing effect, which was considerably stronger in the semi-tandem posture and affected most of the sway variables. Sensory suppression associated with elevated vibration levels on a construction site may increase the danger of losing balance. Construction workers at elevation, e.g., on a beam or narrow plank might be at increased risk of fall if they can detect vibrations under their feet. To reduce the possibility of losing balance, mechanical vibration to supporting structures used as walking/working surfaces should be minimized when performing construction tasks at elevation. JF - Applied Ergonomics AU - Simeonov, P AU - Hsiao, H AU - Powers, J AU - Ammons, D AU - Kau, T AU - Amendola, A AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505, USA, psimeonov@cdc.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 672 EP - 681 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 42 IS - 5 SN - 0003-6870, 0003-6870 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Vibration KW - H 1000:Occupational Safety and Health KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869581858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Postural+stability+effects+of+random+vibration+at+the+feet+of+construction+workers+in+simulated+elevation&rft.au=Simeonov%2C+P%3BHsiao%2C+H%3BPowers%2C+J%3BAmmons%2C+D%3BKau%2C+T%3BAmendola%2C+A&rft.aulast=Simeonov&rft.aufirst=P&rft.date=2011-07-01&rft.volume=42&rft.issue=5&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2010.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vibration DO - http://dx.doi.org/10.1016/j.apergo.2010.10.002 ER - TY - JOUR T1 - Antibody characterization and immunoassays for palytoxin using an SPR biosensor. AN - 869000093; 21523328 AB - Palytoxin (PLTX), a polyether marine toxin originally isolated from the zoanthid Palythoa toxica, is one of the most toxic non-protein substances known. Fatal poisonings have been linked to ingestion of PLTX-contaminated seafood, and effects in humans have been associated with dermal and inhalational exposure to PLTX containing organisms and waters. Additionally, PLTX co-occurrence with other well-characterized seafood toxins (e.g., ciguatoxins, saxitoxins, tetrodotoxin) has hindered direct associations of PLTX to seafood-borne illnesses. There are currently no validated methods for the quantitative detection of PLTX(s). As such, a well-characterized, robust, specific analytical technique is needed for the detection of PLTX(s) in source organisms, surrounding waters, and clinical samples. Surface plasmon resonance (SPR) biosensors are ideally suited for antibody characterization and quantitative immunoassay detection. Herein, we describe a newly developed SPR assay for PLTX. An anti-mouse substrate was used to characterize the kinetic values for a previously developed monoclonal anti-PLTX. The characterized antibody was then incorporated into a sensitive, rapid, and selective PLTX assay. Buffer type, flow rate, analyte-binding time, and regeneration conditions were optimized for the antibody-PLTX system. Cross-reactivity to potentially co-occurring seafood toxins was also evaluated. We show that this optimized assay is capable of measuring low- to sub-ng/mL PLTX levels in buffer and two seafood matrices (grouper and clam). Preliminary results indicate that this SPR biosensor assay allows for (1) rapid characterization of antibodies and (2) rapid, sensitive PLTX concentration determination in seafood matrices. Method development information contained herein may be broadly applied to future PLTX detection and/or antibody characterization efforts. JF - Analytical and bioanalytical chemistry AU - Yakes, Betsy Jean AU - DeGrasse, Stacey L AU - Poli, Mark AU - Deeds, Jonathan R AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA. betsy.yakes@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 2865 EP - 2869 VL - 400 IS - 9 KW - Acrylamides KW - 0 KW - Antibodies, Monoclonal KW - Marine Toxins KW - palytoxin KW - OQ17NC0MOV KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Mice KW - Surface Plasmon Resonance -- methods KW - Marine Toxins -- analysis KW - Acrylamides -- analysis KW - Immunoassay -- methods KW - Anthozoa -- chemistry KW - Marine Toxins -- immunology KW - Acrylamides -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869000093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+bioanalytical+chemistry&rft.atitle=Antibody+characterization+and+immunoassays+for+palytoxin+using+an+SPR+biosensor.&rft.au=Yakes%2C+Betsy+Jean%3BDeGrasse%2C+Stacey+L%3BPoli%2C+Mark%3BDeeds%2C+Jonathan+R&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2011-07-01&rft.volume=400&rft.issue=9&rft.spage=2865&rft.isbn=&rft.btitle=&rft.title=Analytical+and+bioanalytical+chemistry&rft.issn=1618-2650&rft_id=info:doi/10.1007%2Fs00216-011-5019-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-27 N1 - Date created - 2011-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00216-011-5019-y ER - TY - JOUR T1 - Treatment of animal toxicoses: a regulatory perspective. AN - 867481890; 21575782 AB - This article focuses on the regulatory issues to consider when veterinarians are called upon to treat animal toxicoses, in particular those involving food-producing animals. The lack of Food and Drug Administration-approved drugs to treat animal toxicoses has been a long-standing problem. This article reviews extralabel drug use regulations, and the responsibilities of the treating veterinarian. It discusses the legal implications of compounding and the use of unapproved drugs to treat animal toxicoses. Efforts should be made to increase the availability of life-saving antidotal therapies. Published by Elsevier Inc. JF - The Veterinary clinics of North America. Food animal practice AU - Bright, Susan J AU - Murphy, Michael J AU - Steinschneider, Janice C AU - Lovell, Randall A AU - Post, Lynn O AD - Division of Veterinary Product Safety, Office of Surveillance & Compliance, Center for Veterinary Medicine, Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, USA. susan.bright@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 481 EP - 512, x VL - 27 IS - 2 KW - Antidotes KW - 0 KW - Biological Products KW - Index Medicus KW - United States KW - Biological Products -- therapeutic use KW - Off-Label Use -- legislation & jurisprudence KW - Animals KW - United States Food and Drug Administration KW - Drug Approval KW - Drug Residues KW - Off-Label Use -- veterinary KW - Livestock KW - Animal Diseases -- drug therapy KW - Antidotes -- administration & dosage KW - Animal Diseases -- chemically induced KW - Antidotes -- therapeutic use KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867481890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.atitle=Treatment+of+animal+toxicoses%3A+a+regulatory+perspective.&rft.au=Bright%2C+Susan+J%3BMurphy%2C+Michael+J%3BSteinschneider%2C+Janice+C%3BLovell%2C+Randall+A%3BPost%2C+Lynn+O&rft.aulast=Bright&rft.aufirst=Susan&rft.date=2011-07-01&rft.volume=27&rft.issue=2&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.issn=1558-4240&rft_id=info:doi/10.1016%2Fj.cvfa.2011.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-08 N1 - Date created - 2011-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cvfa.2011.02.002 ER - TY - JOUR T1 - Safety of antibiotic drugs in food animals: comparison of findings from preapproval studies and postapproval experience in the United States with safety information in published literature. AN - 867478609; 21575776 AB - Antibiotics are among the most widely prescribed drugs and are generally considered safe for the target species. However, their use has been associated with various adverse toxic effects in target animals, such as allergic reactions, gastrointestinal signs, cardiovascular effects, hypoglycemia, hepatic/renal toxicity, thrombocytopenia, and anaphylaxis. This article provides a qualitative summary of the adverse events observed in target animals during the evaluation of antibiotics by the Food and Drug Administration during both preapproval and postapproval periods. As there is a marked scarcity of published data on safety of antibiotics in food animals, more research is needed in this area. Published by Elsevier Inc. JF - The Veterinary clinics of North America. Food animal practice AU - Modric, Tomislav AU - Modric, Sanja AU - Murphy, Michael J AU - Bright, Susan J AU - Shults, Stacey AD - Office of Surveillance and Compliance, FDA Center for Veterinary Medicine, 7519 Standish Place, Rockville, MD 20855, USA. tomislav.modric@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 389 EP - 405, ix VL - 27 IS - 2 KW - Anti-Bacterial Agents KW - 0 KW - Index Medicus KW - Animals KW - Drug-Related Side Effects and Adverse Reactions KW - United States -- epidemiology KW - Livestock KW - Drug Approval -- methods KW - Animal Diseases -- chemically induced KW - Anti-Bacterial Agents -- adverse effects KW - Product Surveillance, Postmarketing KW - Clinical Trials as Topic KW - Animal Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867478609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.atitle=Safety+of+antibiotic+drugs+in+food+animals%3A+comparison+of+findings+from+preapproval+studies+and+postapproval+experience+in+the+United+States+with+safety+information+in+published+literature.&rft.au=Modric%2C+Tomislav%3BModric%2C+Sanja%3BMurphy%2C+Michael+J%3BBright%2C+Susan+J%3BShults%2C+Stacey&rft.aulast=Modric&rft.aufirst=Tomislav&rft.date=2011-07-01&rft.volume=27&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=The+Veterinary+clinics+of+North+America.+Food+animal+practice&rft.issn=1558-4240&rft_id=info:doi/10.1016%2Fj.cvfa.2011.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-08 N1 - Date created - 2011-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cvfa.2011.02.005 ER - TY - JOUR T1 - Regulatory perspectives on multiplicity in adaptive design clinical trials throughout a drug development program. AN - 863431427; 21516573 AB - A clinical research program for drug development often consists of a sequence of clinical trials that may begin with uncontrolled and nonrandomized trials, followed by randomized trials or randomized controlled trials. Adaptive designs are not infrequently proposed for use. In the regulatory setting, the success of a drug development program can be defined to be that the experimental treatment at a specific dose level including regimen and frequency is approved based on replicated evidence from at least two confirmatory trials. In the early stage of clinical research, multiplicity issues are very broad. What is the maximum tolerable dose in an adaptive dose escalation trial? What should the dose range be to consider in an adaptive dose-ranging trial? What is the minimum effective dose in an adaptive dose-response study given the tolerability and the toxicity observable in short term or premarketing trials? Is establishing the dose-response relationship important or the ability to select a superior treatment with high probability more important? In the later stage of clinical research, multiplicity problems can be formulated with better focus, depending on whether the study is for exploration to estimate or select design elements or for labeling consideration. What is the study objective for an early-phase versus a later phase adaptive clinical trial? How many doses are to be studied in the early exploratory adaptive trial versus in the confirmatory adaptive trial? Is the intended patient population well defined or is the applicable patient population yet to be adaptively selected in the trial due to the potential patient and/or disease heterogeneity? Is the primary efficacy endpoint well defined or still under discussion providing room for adaptation? What are the potential treatment indications that may adaptively lead to an intended-to-treat patient population and the primary efficacy endpoint? In this work we stipulate the multiplicity issues with adaptive designs encountered in regulatory applications. For confirmatory adaptive design clinical trials, controlling studywise type I error and type II error is of paramount importance. For exploratory adaptive trials, we define the probability of correct selection of design features, e.g., dose, effect size, and the probability of correct decision for drug development. We assert that maximizing these probabilities would be critical to determine whether the drug development program continues or how to plan the confirmatory trials if the development continues. JF - Journal of biopharmaceutical statistics AU - Wang, Sue-Jane AU - Hung, H M James AU - O'Neill, Robert AD - Office of Biostatistics, OTS/CDER, FDA, Silver Spring, Maryland 20993-0002, USA. suejane.wang@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - July 2011 SP - 846 EP - 859 VL - 21 IS - 4 KW - Index Medicus KW - Probability KW - Endpoint Determination KW - Sample Size KW - Research Design -- statistics & numerical data KW - Drug Discovery -- statistics & numerical data KW - Clinical Trials as Topic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863431427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biopharmaceutical+statistics&rft.atitle=Regulatory+perspectives+on+multiplicity+in+adaptive+design+clinical+trials+throughout+a+drug+development+program.&rft.au=Wang%2C+Sue-Jane%3BHung%2C+H+M+James%3BO%27Neill%2C+Robert&rft.aulast=Wang&rft.aufirst=Sue-Jane&rft.date=2011-07-01&rft.volume=21&rft.issue=4&rft.spage=846&rft.isbn=&rft.btitle=&rft.title=Journal+of+biopharmaceutical+statistics&rft.issn=1520-5711&rft_id=info:doi/10.1080%2F10543406.2011.552878 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-02 N1 - Date created - 2011-04-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/10543406.2011.552878 ER - TY - JOUR T1 - Identification and Categorization of Liver Toxicity Markers Induced by a Related Pair of Drugs AN - 1356925199; 15891100 AB - Drug-induced liver injury (DILI) is the primary adverse event that results in the withdrawal of drugs from the market and a frequent reason for the failure of drug candidates in the pre-clinical or clinical phases of drug development. This paper presents an approach for identifying potential liver toxicity genomic biomarkers from a liver toxicity biomarker study involving the paired compounds entacapone ("non-liver toxic drug") and tolcapone ("hepatotoxic drug"). Molecular analysis of the rat liver and plasma samples, combined with statistical analysis, revealed many similarities and differences between the in vivo biochemical effects of the two drugs. Six hundred and ninety-five genes and 61 pathways were selected based on the classification scheme. Of the 61 pathways, 5 were specific to treatment with tolcapone. Two of the 12 animals in the tolcapone group were found to have high ALT, AST, or TBIL levels. The gene Vars2 (valyl-tRNA synthetase 2) was identified in both animals and the pathway to which it belongs, the aminoacyl-tRNA biosynthesis pathway, was one of the three most significant tolcapone-specific pathways identified. JF - International Journal of Molecular Sciences AU - Chang, C-W AU - Beland, F A AU - Hines, WM AU - Fuscoe, J C AU - Han, T AU - Chen, J J AD - Division of Personalized Nutrition and Medicine, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 4609 EP - 4624 VL - 12 IS - 7 SN - 1422-0067, 1422-0067 KW - Toxicology Abstracts KW - tolcapone KW - Classification KW - Injuries KW - Liver KW - Statistical analysis KW - Drug development KW - Toxicity KW - genomics KW - Drugs KW - biomarkers KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Molecular+Sciences&rft.atitle=Identification+and+Categorization+of+Liver+Toxicity+Markers+Induced+by+a+Related+Pair+of+Drugs&rft.au=Chang%2C+C-W%3BBeland%2C+F+A%3BHines%2C+WM%3BFuscoe%2C+J+C%3BHan%2C+T%3BChen%2C+J+J&rft.aulast=Chang&rft.aufirst=C-W&rft.date=2011-07-01&rft.volume=12&rft.issue=7&rft.spage=4609&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Molecular+Sciences&rft.issn=14220067&rft_id=info:doi/10.3390%2Fijms12074609 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - tolcapone; Injuries; Classification; Statistical analysis; Liver; Drug development; genomics; Toxicity; biomarkers; Drugs DO - http://dx.doi.org/10.3390/ijms12074609 ER - TY - JOUR T1 - DFAspike: A new computational proposition for efficient recognition of epileptic spike in EEG AN - 1033019324 AB - An automated method has been presented for the detection of epileptic spikes in the electroencephalogram (EEG) using a deterministic finite automata (DFA) and has been named as DFAspike. EEG data (sampled, 256Hz) files are the inputs to the DFAspike. The DFAspike was tested with different data files containing epileptic spikes. The obtained recognition rate of epileptic spike was 99.13% on an average. This system does not require any kind of prior training or human intrusion. The result shows that the designed system can be very effectively used for the detection of spikes present in the recorded EEG signals. JF - Computers in Biology and Medicine AU - Keshri, Anup Kumar AU - Sinha, Rakesh Kumar AU - Singh, Aishwarya AU - Nand Das, Barda Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 559 EP - 564 CY - Oxford PB - Elsevier Limited VL - 41 IS - 7 SN - 00104825 KW - Medical Sciences--Computer Applications KW - Deterministic finite automata KW - Electroencephalogram KW - Epileptic spike KW - Real time diagnostic machine KW - Epilepsy KW - Studies KW - Brain KW - Accuracy KW - Automation KW - Algorithms KW - Signal processing KW - Electroencephalography KW - Electrodes KW - Pattern recognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1033019324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Biology+and+Medicine&rft.atitle=DFAspike%3A+A+new+computational+proposition+for+efficient+recognition+of+epileptic+spike+in+EEG&rft.au=Keshri%2C+Anup+Kumar%3BSinha%2C+Rakesh+Kumar%3BSingh%2C+Aishwarya%3BNand+Das%2C+Barda&rft.aulast=Keshri&rft.aufirst=Anup&rft.date=2011-07-01&rft.volume=41&rft.issue=7&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Computers+in+Biology+and+Medicine&rft.issn=00104825&rft_id=info:doi/10.1016%2Fj.compbiomed.2011.05.007 LA - English DB - ProQuest Central N1 - Copyright - © 2011 Elsevier Ltd N1 - Last updated - 2013-10-25 N1 - CODEN - CBMDAW DO - http://dx.doi.org/10.1016/j.compbiomed.2011.05.007 ER - TY - JOUR T1 - MicroRNAs and their predicted target messenger RNAs are deregulated by Exposure to a Carcinogenic Dose of Comfrey in Rat Liver AN - 1020840970; 16695276 AB - MicroRNAs (MiRNAs) are small noncoding RNAs that function as regulators of gene expression to control cell growth and differentiation. In this study, we analyzed miRNA and mRNA expression in the livers of rats treated with a carcinogenic dose of comfrey (Symphytum officinale) for 12 weeks. Groups of six rats were fed a normal diet or a diet containing 8% comfrey root. The animals were sacrificed 1 day after the last treatment and the livers were isolated for miRNA expression analysis using LC Sciences miRNA microarrays and for mRNA expression analysis using Affymetrix rat genome microarrays. MiRNA expression levels were significantly changed by comfrey treatment. The treated samples were separated clearly from the control samples in both principal component analysis (PCA) and hierarchical clustering analysis (HCA). Quantitative measurements of seven miRNAs using TaqMan real-time PCR were consistent with the microarray results in terms of fold-change and the direction of the change in expression. Forty-five miRNAs (P < 0.01) and 1,921 mRNAs (q = 0) were significantly changed by comfrey treatment. Using a target prediction algorithm, 434 differentially expressed genes (DEGs) were predicted to be targeted by the differentially expressed miRNAs (DEMs). The DEM-targeted DEGs were more likely to be involved in carcinogenesis than the DEGs that were not targeted by the DEMs. The nontargeted DEGs were enriched in noncancer-related biological processes. Our data suggest that comfrey may exert its carcinogenic effects by disturbing miRNA expression resulting in altered mRNA levels of the DEM-targeted genes that are functionally associated with carcinogenesis. Environ. Mol. Mutagen., 2011. ? Published 2011 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Li, Zhiguang AU - Fuscoe, James C AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, tao.chen@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 469 EP - 478 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 6 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Water Resources Abstracts KW - Prediction KW - Genomes KW - Mutagens KW - deregulation KW - Principal Component Analysis KW - Algorithms KW - Roots KW - DNA microarrays KW - Mutagenesis KW - Rats KW - Gene expression KW - Differentiation KW - Carcinogenicity KW - Exposure KW - Polymerase chain reaction KW - Symphytum officinale KW - Diets KW - Data processing KW - principal components analysis KW - miRNA KW - mRNA KW - Principal components analysis KW - Carcinogenesis KW - Liver KW - SW 3050:Ultimate disposal of wastes KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020840970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=MicroRNAs+and+their+predicted+target+messenger+RNAs+are+deregulated+by+Exposure+to+a+Carcinogenic+Dose+of+Comfrey+in+Rat+Liver&rft.au=Li%2C+Zhiguang%3BFuscoe%2C+James+C%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Zhiguang&rft.date=2011-07-01&rft.volume=52&rft.issue=6&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20645 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20645/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Diets; Genomes; Mutagens; Data processing; miRNA; Algorithms; Roots; DNA microarrays; Mutagenesis; mRNA; Gene expression; Differentiation; Principal components analysis; Carcinogenesis; Liver; Polymerase chain reaction; Prediction; Rats; deregulation; principal components analysis; Carcinogenicity; Exposure; Principal Component Analysis; Symphytum officinale DO - http://dx.doi.org/10.1002/em.20645 ER - TY - JOUR T1 - Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial AN - 1017971824; 16703801 AB - Objectives Women with a sonographic short cervix in the mid-trimester are at increased risk for preterm delivery. This study was undertaken to determine the efficacy and safety of using micronized vaginal progesterone gel to reduce the risk of preterm birth and associated neonatal complications in women with a sonographic short cervix. Methods This was a multicenter, randomized, double-blind, placebo-controlled trial that enrolled asymptomatic women with a singleton pregnancy and a sonographic short cervix (10-20 mm) at 19 + 0 to 23 + 6 weeks of gestation. Women were allocated randomly to receive vaginal progesterone gel or placebo daily starting from 20 to 23 + 6 weeks until 36 + 6 weeks, rupture of membranes or delivery, whichever occurred first. Randomization sequence was stratified by center and history of a previous preterm birth. The primary endpoint was preterm birth before 33 weeks of gestation. Analysis was by intention to treat. Results Of 465 women randomized, seven were lost to follow-up and 458 (vaginal progesterone gel, n = 235; placebo, n = 223) were included in the analysis. Women allocated to receive vaginal progesterone had a lower rate of preterm birth before 33 weeks than did those allocated to placebo (8.9% (n = 21) vs 16.1% (n = 36); relative risk (RR), 0.55; 95% CI, 0.33-0.92; P = 0.02). The effect remained significant after adjustment for covariables (adjusted RR, 0.52; 95% CI, 0.31-0.91; P = 0.02). Vaginal progesterone was also associated with a significant reduction in the rate of preterm birth before 28 weeks (5.1% vs 10.3%; RR, 0.50; 95% CI, 0.25-0.97; P = 0.04) and 35 weeks (14.5% vs 23.3%; RR, 0.62; 95% CI, 0.42-0.92; P = 0.02), respiratory distress syndrome (3.0% vs 7.6%; RR, 0.39; 95% CI, 0.17-0.92; P = 0.03), any neonatal morbidity or mortality event (7.7% vs 13.5%; RR, 0.57; 95% CI, 0.33-0.99; P = 0.04) and birth weight < 1500 g (6.4% (15/234) vs 13.6% (30/220); RR, 0.47; 95% CI, 0.26-0.85; P = 0.01). There were no differences in the incidence of treatment-related adverse events between the groups. Conclusions The administration of vaginal progesterone gel to women with a sonographic short cervix in the mid-trimester is associated with a 45% reduction in the rate of preterm birth before 33 weeks of gestation and with improved neonatal outcome. JF - Ultrasound in Obstetrics and Gynecology AU - Hassan, S S AU - Romero, R AU - Vidyadhari, D AU - Fusey, S AU - Baxter, J K AU - Khandelwal, M AU - Vijayaraghavan, J AU - Trivedi, Y AU - Soma-Pillay, P AU - Sambarey, P AU - Dayal, A AU - Potapov, V AU - O'Brien, J AU - Astakhov, V AU - Yuzko, O AU - Kinzler, W AU - Dattel, B AU - Sehdev, H AU - Mazheika, L AU - Manchulenko, D AU - Gervasi, M T AU - Sullivan, L AU - Conde-Agudelo, A AU - Phillips, J A AU - Creasy, G W AD - Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health/Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 18 EP - 31 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 38 IS - 1 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Birth weight KW - Cervix KW - Gestation KW - Gynecology KW - Morbidity KW - Mortality KW - Motivation KW - Neonates KW - Obstetrics KW - Pregnancy KW - Progesterone KW - Respiratory distress syndrome KW - Risk assessment KW - Rupture KW - Ultrasound KW - Vagina KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017971824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Vaginal+progesterone+reduces+the+rate+of+preterm+birth+in+women+with+a+sonographic+short+cervix%3A+a+multicenter%2C+randomized%2C+double-blind%2C+placebo-controlled+trial&rft.au=Hassan%2C+S+S%3BRomero%2C+R%3BVidyadhari%2C+D%3BFusey%2C+S%3BBaxter%2C+J+K%3BKhandelwal%2C+M%3BVijayaraghavan%2C+J%3BTrivedi%2C+Y%3BSoma-Pillay%2C+P%3BSambarey%2C+P%3BDayal%2C+A%3BPotapov%2C+V%3BO%27Brien%2C+J%3BAstakhov%2C+V%3BYuzko%2C+O%3BKinzler%2C+W%3BDattel%2C+B%3BSehdev%2C+H%3BMazheika%2C+L%3BManchulenko%2C+D%3BGervasi%2C+M+T%3BSullivan%2C+L%3BConde-Agudelo%2C+A%3BPhillips%2C+J+A%3BCreasy%2C+G+W&rft.aulast=Hassan&rft.aufirst=S&rft.date=2011-07-01&rft.volume=38&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.9017 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.9017/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Birth weight; Mortality; Motivation; Progesterone; Gynecology; Rupture; Morbidity; Pregnancy; Birth; Vagina; Gestation; Respiratory distress syndrome; Neonates; Cervix; Obstetrics; Ultrasound DO - http://dx.doi.org/10.1002/uog.9017 ER - TY - JOUR T1 - Increased expression of miR-34a in mouse spleen one day after exposure to N-ethyl-N-nitrosourea AN - 1017970634; 16699328 AB - Keywords: miR-34a; p53; mutagen; N-ethyl-N-nitrosourea; Real-time PCR ABSTRACT MicroRNAs (miRNAs) are a class of single-stranded small RNA molecules (~22 nucleotides) that are not translated into proteins and function as regulators of gene expression. Many miRNAs are involved in carcinogenesis. One of them, miR-34a, is associated with various p53-initiated biological processes and may act as a tumor suppressor miRNA. Its expression is generally down-regulated in tumor tissues and up-regulated in tissues exposed to carcinogens chronically or subchronically. However, the response of this miRNA to acute exposure of a genotoxic carcinogen is little known. In this study, miR-34a expression was evaluated in spleen tissues of mice treated with a dose of 120mgkg-1 body weight N-ethyl-N-nitrosourea (ENU), a potent mutagenic carcinogen. Real-time PCR analysis showed that the ENU exposure resulted in a 5.5-fold increase of miR-34a expression over the control one day after the treatment. The result suggests that miR-34a expression responds sensitively to genotoxic insults within a short period after exposure of the mutagen, and therefore, this gene has the potential to be used as an indicator for genotoxin exposure. JF - Journal of Applied Toxicology AU - Anonymous AD - Little Rock Central High School, Little Rock, AR, USA, zhiguang.li@fda.hhs.gov Y1 - 2011/07// PY - 2011 DA - Jul 2011 SP - 496 EP - 498 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 31 IS - 5 SN - 1099-1263, 1099-1263 KW - Toxicology Abstracts KW - Mutagens KW - Tumor suppressor genes KW - Genotoxicity KW - miRNA KW - Spleen KW - Tumors KW - Carcinogens KW - Nucleotides KW - p53 protein KW - Gene expression KW - Body weight KW - RNA KW - Carcinogenesis KW - Polymerase chain reaction KW - Ethyl nitrosourea KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Increased+expression+of+miR-34a+in+mouse+spleen+one+day+after+exposure+to+N-ethyl-N-nitrosourea&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-07-01&rft.volume=31&rft.issue=5&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1640 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1640/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Mutagens; miRNA; Genotoxicity; Spleen; Carcinogens; Tumors; Nucleotides; p53 protein; Gene expression; RNA; Body weight; Carcinogenesis; Ethyl nitrosourea; Polymerase chain reaction DO - http://dx.doi.org/10.1002/jat.1640 ER - TY - JOUR T1 - Dietary nitrate and nitrite and the risk of thyroid cancer in the NIH-AARP Diet and Health Study AN - 1017962123; 16689935 AB - During the past several decades, an increasing incidence of thyroid cancer has been observed worldwide. Nitrate inhibits iodide uptake by the thyroid, potentially disrupting thyroid function. An increased risk of thyroid cancer associated with nitrate intake was recently reported in a cohort study of older women in Iowa. We evaluated dietary nitrate and nitrite intake and thyroid cancer risk overall and for subtypes in the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study, a large prospective cohort of 490,194 men and women, ages 50-71 years in 1995-1996. Dietary intakes were assessed using a 124-item food frequency questionnaire. During an average of 7 years of follow-up we identified 370 incident thyroid cancer cases (170 men, 200 women) with complete dietary information. Among men, increasing nitrate intake was positively associated with thyroid cancer risk (relative risk [RR] for the highest quintile versus lowest quintile RR = 2.28, 95% confidence interval [CI]: 1.29-4.041; p-trend <0.001); however, we observed no trend with intake among women (p-trend = 0.61). Nitrite intake was not associated with risk of thyroid cancer for either men or women. We evaluated risk for the two main types of thyroid cancer. We found positive associations for nitrate intake and both papillary (RR = 2.10; 95% CI: 1.09-4.05; p-trend = 0.05) and follicular thyroid cancer (RR = 3.42; 95% CI: 1.03-11.4; p-trend = 0.01) among men. Nitrite intake was associated with increased risk of follicular thyroid cancer (RR = 2.74; 95%CI: 0.86-8.77; p-trend = 0.04) among men. Our results support a role of nitrate in thyroid cancer risk and suggest that further studies to investigate these exposures are warranted. JF - International Journal of Cancer AU - Kilfoy, Briseis A AU - Zhang, Yawei AU - Park, Yikyung AU - Holford, Theodore R AU - Schatzkin, Arthur AU - Hollenbeck, Albert AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, kilfoyb@mail.nih.gov Y1 - 2011/07/01/ PY - 2011 DA - 2011 Jul 01 SP - 160 EP - 172 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 1 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Cancer KW - Diets KW - Ingestion KW - Iodides KW - Nitrates KW - Nitrites KW - Thyroid KW - iodides KW - USA, Iowa KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Dietary+nitrate+and+nitrite+and+the+risk+of+thyroid+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Kilfoy%2C+Briseis+A%3BZhang%2C+Yawei%3BPark%2C+Yikyung%3BHolford%2C+Theodore+R%3BSchatzkin%2C+Arthur%3BHollenbeck%2C+Albert%3BWard%2C+Mary+H&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2011-07-01&rft.volume=129&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25650 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25650/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diets; Iodides; Age; Nitrites; Nitrates; iodides; Thyroid; Ingestion; Cancer; USA, Iowa DO - http://dx.doi.org/10.1002/ijc.25650 ER - TY - CPAPER T1 - Computer Recycling: Ruining Your Health to Make Money on the Side T2 - 2011 104th Air and Waste Management Association Annual Conference (A&WMA's 2011) AN - 1312945213; 6084263 JF - 2011 104th Air and Waste Management Association Annual Conference (A&WMA's 2011) AU - Heckel, P AU - Heidel, D AU - Bernstein, J Y1 - 2011/06/21/ PY - 2011 DA - 2011 Jun 21 KW - Recycling KW - Waste management KW - Computers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312945213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+104th+Air+and+Waste+Management+Association+Annual+Conference+%28A%26WMA%27s+2011%29&rft.atitle=Computer+Recycling%3A+Ruining+Your+Health+to+Make+Money+on+the+Side&rft.au=Heckel%2C+P%3BHeidel%2C+D%3BBernstein%2C+J&rft.aulast=Heckel&rft.aufirst=P&rft.date=2011-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+104th+Air+and+Waste+Management+Association+Annual+Conference+%28A%26WMA%27s+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://events.awma.org/ace2011/PRINTER%20READY%20FINAL%20PROGRAM.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury. AN - 873123818; 21557537 AB - C57BL/6 mice are widely used in biomedical research for the background of genetically engineered mice (GEM) and wild-type controls with the belief that the genetic background of GEM and control mice differ significantly by only one or more altered genes. This principle, however, does have limitations due in part to the existence of multiple substrains of C57BL/6 mice that should not be used interchangeably as they can differ both genetically and phenotypically. We show here that these mispairings do occur frequently and can lead to inaccurate and conflicting findings. JF - Chemical research in toxicology AU - Bourdi, Mohammed AU - Davies, John S AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1760, United States. bourdim@nhlbi.nih.gov Y1 - 2011/06/20/ PY - 2011 DA - 2011 Jun 20 SP - 794 EP - 796 VL - 24 IS - 6 KW - Analgesics, Non-Narcotic KW - 0 KW - Mitogens KW - Concanavalin A KW - 11028-71-0 KW - Acetaminophen KW - 362O9ITL9D KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Index Medicus KW - Genotype KW - Animals KW - Gene Knockdown Techniques KW - Mice KW - Mice, Knockout KW - Mitogen-Activated Protein Kinase 9 -- genetics KW - Mice, Inbred C57BL -- genetics KW - Concanavalin A -- toxicity KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Analgesics, Non-Narcotic -- toxicity KW - Mitogens -- toxicity KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Acetaminophen -- toxicity KW - Mice, Transgenic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/873123818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Mispairing+C57BL%2F6+substrains+of+genetically+engineered+mice+and+wild-type+controls+can+lead+to+confounding+results+as+it+did+in+studies+of+JNK2+in+acetaminophen+and+concanavalin+A+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BDavies%2C+John+S%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2011-06-20&rft.volume=24&rft.issue=6&rft.spage=794&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200143x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-14 N1 - Date created - 2011-06-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1425-9 [10845854] Transgenic Res. 2011 Jun;20(3):481-9 [20506040] Genes Brain Behav. 2004 Jun;3(3):149-57 [15140010] Cancer Lett. 1980 Apr;9(2):111-5 [7379041] Cell Immunol. 1987 Dec;110(2):294-304 [2446778] Hum Mol Genet. 2006 Apr 1;15(7):1187-94 [16497723] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] Chem Res Toxicol. 2007 May;20(5):734-44 [17439248] Gut. 2007 Jul;56(7):982-90 [17185352] Alcohol Clin Exp Res. 2007 Oct;31(10):1669-76 [17651469] Genome Res. 2008 Jan;18(1):60-6 [18032724] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Biochem Biophys Res Commun. 2008 Sep 12;374(1):6-10 [18586006] Genes Brain Behav. 2008 Aug;7(6):677-89 [18397380] Am J Pathol. 2008 Oct;173(4):962-72 [18772342] Gastroenterology. 2008 Oct;135(4):1311-21 [18700144] J Neurogenet. 2008;22(4):315-31 [19085272] Exp Anim. 2009 Apr;58(2):141-9 [19448337] Br J Nutr. 2010 Feb;103(4):513-21 [19840420] Behav Genet. 2010 Mar;40(2):201-10 [20033273] Obesity (Silver Spring). 2010 Oct;18(10):1902-5 [20057372] Comp Med. 2000 Jun;50(3):288-91 [10894494] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200143x ER - TY - JOUR T1 - The role of epigenetic events in genotoxic hepatocarcinogenesis induced by 2-acetylaminofluorene. AN - 870292700; 20188851 AB - It is well established that genotoxic reactivity of chemical carcinogens or their metabolites is a critical event in the initiation of tumorigenesis. However, the underlying mechanisms of events following initiation are less well understood, and with respect to genotoxic liver carcinogenesis, it is largely unknown how the initiated cells progress to form preneoplastic hepatic foci. In the present study, we investigated the underlying events associated with tumor-promoting activity of 2-acetylaminofluorene (2-AAF), a powerful complete genotoxic rat liver carcinogen. Male Sprague-Dawley rats were fed NIH-31 diet containing 0.02% of 2-AAF for 24 weeks, and the status of cytosine DNA methylation, histone methylation, and microRNA expression was determined in the livers of control and 2-AAF-fed rats. The results demonstrate that stages of multistage carcinogenesis following the initiation are driven primarily by carcinogen-induced epigenetic alterations. This was evidenced by altered global histone lysine methylation patterns, increased histone H3 lysine 9 and histone H3 lysine 27 trimethylation in the promoter regions of Rassf1a, p16(INK4a), Socs1, Cdh1, and Cx26 tumor suppressor genes, early Rassf1a and p16(INK4a) promoter CpG island hypermethylation, and altered microRNA expression in preneoplastic livers of rats exposed to 2-AAF. These changes were accompanied by dysregulation of the balance between cell proliferation and apoptosis, a fundamental pro-tumorigenic event in hepatocarcinogenesis. These results signify the fundamental role of epigenetic alterations in genotoxic liver carcinogenesis. Published by Elsevier B.V. JF - Mutation research AU - Pogribny, Igor P AU - Muskhelishvili, Levan AU - Tryndyak, Volodymyr P AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2011/06/17/ PY - 2011 DA - 2011 Jun 17 SP - 106 EP - 113 VL - 722 IS - 2 SN - 0027-5107, 0027-5107 KW - Histones KW - 0 KW - MicroRNAs KW - Mutagens KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - MicroRNAs -- metabolism KW - DNA Methylation KW - Histones -- metabolism KW - Apoptosis -- drug effects KW - Male KW - Liver Neoplasms, Experimental -- genetics KW - 2-Acetylaminofluorene -- toxicity KW - 2-Acetylaminofluorene -- pharmacology KW - DNA Damage KW - Mutagens -- toxicity KW - Liver Neoplasms, Experimental -- chemically induced KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/870292700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=The+role+of+epigenetic+events+in+genotoxic+hepatocarcinogenesis+induced+by+2-acetylaminofluorene.&rft.au=Pogribny%2C+Igor+P%3BMuskhelishvili%2C+Levan%3BTryndyak%2C+Volodymyr+P%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2011-06-17&rft.volume=722&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2010.02.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-23 N1 - Date created - 2011-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2010.02.011 ER - TY - JOUR T1 - Alcohol and endometrial cancer risk in the NIH-AARP diet and health study AN - 1017965888; 16689964 AB - Previous investigations have provided conflicting results regarding whether alcohol consumption affects endometrial cancer risk, although in many of these studies the highest category of alcohol intake examined was limited. Further, most were unable to resolve how alcohol associations are affected by beverage type, the presence of other endometrial cancer risk factors, or tumor characteristics. To address these issues, we prospectively evaluated the association between alcohol intake and incident endometrial cancer (n = 1,491) in a cohort of 114,414 US women enrolled in the NIH-AARP Diet and Health Study. We calculated relative risks (RR) and 95% confidence intervals (CI) using Cox proportional hazards regression. After adjustment for age, body mass index (BMI), smoking and other potential confounders, the multivariable RRs (and 95% CIs) compared with nondrinkers were 0.97 (0.87-1.09) for >0-=24 g/day (p trend = 0.90). There was, however, some suggestion of higher risks associated with alcohol consumption among lean women (BMI, <25) and users of menopausal hormone therapy, with significant interactions with both parameters (respective interaction p-values of 0.002 and 0.005). The relationship was also enhanced, albeit nonsignificantly so, for low grade cancers. Our results do not support that alcohol is a strong contributor to endometrial cancer risk, but slight risk increases may prevail among some users or for selected tumor characteristics. JF - International Journal of Cancer AU - Yang, Hannah P AU - Gierach, Gretchen L AU - Danforth, Kim N AU - Sherman, Mark E AU - Park, Yikyung AU - Wentzensen, Nicolas AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Brinton, Louise A AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, yanghan@mail.nih.gov Y1 - 2011/06/15/ PY - 2011 DA - 2011 Jun 15 SP - 2953 EP - 2961 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 12 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Alcohol KW - Body mass KW - Cancer KW - Diets KW - Hormones KW - Risk factors KW - Smoking KW - Tumors KW - body mass KW - tumors KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Alcohol+and+endometrial+cancer+risk+in+the+NIH-AARP+diet+and+health+study&rft.au=Yang%2C+Hannah+P%3BGierach%2C+Gretchen+L%3BDanforth%2C+Kim+N%3BSherman%2C+Mark+E%3BPark%2C+Yikyung%3BWentzensen%2C+Nicolas%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BBrinton%2C+Louise+A&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2011-06-15&rft.volume=128&rft.issue=12&rft.spage=2953&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25623 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25623/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Alcohol; Age; body mass; Body mass; Risk factors; tumors; Tumors; Hormones; Cancer DO - http://dx.doi.org/10.1002/ijc.25623 ER - TY - JOUR T1 - Sodium nitrite induces acute central nervous system toxicity in guinea pigs exposed to systemic cell-free hemoglobin AN - 1028077534; 15092179 AB - Systemic cell-free hemoglobin (Hb) released via hemolysis disrupts vascular homeostasis, in part, through the scavenging of nitric oxide (NO). Sodium nitrite (NaNO2) therapy can attenuate the hypertensive effects of Hb. However, the chemical reactivity of NaNO2 with Hb may enhance heme- or iron-mediated toxicities. Here, we investigate the effect of NaNO2 on the central nervous system (CNS) in guinea pigs exposed to systemic cell-free Hb. Intravascular infusion of NaNO2, at doses sufficient to alleviate Hb-mediated blood pressure changes, reduced the expression of occludin, but not zona occludens-1 (ZO-1) or claudin-5, in cerebral tight junctions 4h after Hb infusion. This was accompanied by increased perivascular heme oxygenase-1 expression, neuronal iron deposition, increased astrocyte and microglial activation, and reduced expression of neuron-specific nuclear protein (NeuN). These CNS changes were not observed in animals treated with Hb or NaNO2 alone. Taken together, these findings suggest that the use of nitrite salts to treat systemic Hb exposure may promote acute CNS toxicity. JF - Biochemical and Biophysical Research Communications AU - Buehler, Paul W AU - Butt, Omer I AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA, felice.dagnillo@fda.hhs.gov Y1 - 2011/06/10/ PY - 2011 DA - 2011 Jun 10 SP - 412 EP - 417 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 409 IS - 3 SN - 0006-291X, 0006-291X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Tight junctions KW - Astrocytes KW - Heme oxygenase (decyclizing) KW - Zonula occludens-1 protein KW - Homeostasis KW - Sodium nitrite KW - Toxicity KW - Blood pressure KW - Hemoglobin KW - Salts KW - Hemolysis KW - Nitric oxide KW - Nitrite KW - Iron KW - N3 11008:Neurochemistry KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028077534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Sodium+nitrite+induces+acute+central+nervous+system+toxicity+in+guinea+pigs+exposed+to+systemic+cell-free+hemoglobin&rft.au=Buehler%2C+Paul+W%3BButt%2C+Omer+I%3BD%27Agnillo%2C+Felice&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2011-06-10&rft.volume=409&rft.issue=3&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2011.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Central nervous system; Astrocytes; Tight junctions; Zonula occludens-1 protein; Heme oxygenase (decyclizing); Toxicity; Sodium nitrite; Homeostasis; Blood pressure; Hemoglobin; Salts; Hemolysis; Nitric oxide; Nitrite; Iron DO - http://dx.doi.org/10.1016/j.bbrc.2011.05.009 ER - TY - CPAPER T1 - Safe Aquaculture Products - Where Are We? T2 - 2011 World Aquaculture Society Meetings AN - 1312996384; 6076478 JF - 2011 World Aquaculture Society Meetings AU - Montwill, Barbara Y1 - 2011/06/06/ PY - 2011 DA - 2011 Jun 06 KW - aquaculture products KW - Aquaculture products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+World+Aquaculture+Society+Meetings&rft.atitle=Safe+Aquaculture+Products+-+Where+Are+We%3F&rft.au=Montwill%2C+Barbara&rft.aulast=Montwill&rft.aufirst=Barbara&rft.date=2011-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+World+Aquaculture+Society+Meetings&rft.issn=&rft_id=info:doi/ L2 - https://www.was.org/WasMeetings/meetings/Default.aspx?code=WA2011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Aquaculture Food Security, Trade, and Food Safety...how They Are Intimately Connected T2 - 2011 World Aquaculture Society Meetings AN - 1312996349; 6076477 JF - 2011 World Aquaculture Society Meetings AU - Koonse, Brett Y1 - 2011/06/06/ PY - 2011 DA - 2011 Jun 06 KW - Food security KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+World+Aquaculture+Society+Meetings&rft.atitle=Aquaculture+Food+Security%2C+Trade%2C+and+Food+Safety...how+They+Are+Intimately+Connected&rft.au=Koonse%2C+Brett&rft.aulast=Koonse&rft.aufirst=Brett&rft.date=2011-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+World+Aquaculture+Society+Meetings&rft.issn=&rft_id=info:doi/ L2 - https://www.was.org/WasMeetings/meetings/Default.aspx?code=WA2011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Chemotheraputics Residue Sample Program and the U.S. Food and Drug Administration T2 - 2011 World Aquaculture Society Meetings AN - 1312961254; 6076532 JF - 2011 World Aquaculture Society Meetings AU - Koonse, Brett Y1 - 2011/06/06/ PY - 2011 DA - 2011 Jun 06 KW - USA KW - Residues KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+World+Aquaculture+Society+Meetings&rft.atitle=Chemotheraputics+Residue+Sample+Program+and+the+U.S.+Food+and+Drug+Administration&rft.au=Koonse%2C+Brett&rft.aulast=Koonse&rft.aufirst=Brett&rft.date=2011-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+World+Aquaculture+Society+Meetings&rft.issn=&rft_id=info:doi/ L2 - https://www.was.org/WasMeetings/meetings/Default.aspx?code=WA2011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Kinematic performance of a six degree-of-freedom hand model (6DHand) for use in occupational biomechanics AN - 874181154; 14960388 AB - Upper extremity musculoskeletal disorders represent an important health issue across all industry sectors; as such, the need exists to develop models of the hand that provide comprehensive biomechanics during occupational tasks. Previous optical motion capture studies used a single marker on the dorsal aspect of finger joints, allowing calculation of one and two degree-of-freedom (DOF) joint angles; additional algorithms were needed to define joint centers and the palmar surface of fingers. We developed a 6DOF model (6DHand) to obtain unconstrained kinematics of finger segments, modeled as frusta of right circular cones that approximate the palmar surface. To evaluate kinematic performance, twenty subjects gripped a cylindrical handle as a surrogate for a powered hand tool. We hypothesized that accessory motions (metacarpophalangeal pronation/supination; proximal and distal interphalangeal radial/ulnar deviation and pronation/supination; all joint translations) would be small (less than 5[deg] rotations, less than 2 mm translations) if segment anatomical reference frames were aligned correctly, and skin movement artifacts were negligible. For the gripping task, 93 of 112 accessory motions were small by our definition, suggesting this 6DOF approach appropriately models joints of the fingers. Metacarpophalangeal supination was larger than expected (approximately 10[deg]), and may be adjusted through local reference frame optimization procedures previously developed for knee kinematics in gait analysis. Proximal translations at the metacarpophalangeal joints (approximately 10 mm) were explained by skin movement across the metacarpals, but would not corrupt inverse dynamics calculated for the phalanges. We assessed performance in this study; a more rigorous validation would likely require medical imaging. JF - Journal of Biomechanics AU - Buczek, Frank L AU - Sinsel, Erik W AU - Gloekler, Daniel S AU - Wimer, Bryan M AU - Warren, Christopher M AU - Wu, John Z AD - National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road MS 2027, Morgantown, WV 26505, United States, fbuczek@cdc.gov Y1 - 2011/06/03/ PY - 2011 DA - 2011 Jun 03 SP - 1805 EP - 1809 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 44 IS - 9 SN - 0021-9290, 0021-9290 KW - Health & Safety Science Abstracts KW - Biomechanics KW - Hand KW - Finger KW - Model KW - Six degree-of-freedom KW - Occupational safety KW - Skin KW - biomechanics KW - musculoskeletal system KW - artifacts KW - hand tools KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874181154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Kinematic+performance+of+a+six+degree-of-freedom+hand+model+%286DHand%29+for+use+in+occupational+biomechanics&rft.au=Buczek%2C+Frank+L%3BSinsel%2C+Erik+W%3BGloekler%2C+Daniel+S%3BWimer%2C+Bryan+M%3BWarren%2C+Christopher+M%3BWu%2C+John+Z&rft.aulast=Buczek&rft.aufirst=Frank&rft.date=2011-06-03&rft.volume=44&rft.issue=9&rft.spage=1805&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2011.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Skin; biomechanics; hand tools; artifacts; musculoskeletal system DO - http://dx.doi.org/10.1016/j.jbiomech.2011.04.003 ER - TY - RPRT T1 - 2009 Autism Spectrum Disorder Research: Portfolio Analysis Report AN - 964172569; ED524614 AB - In 2010, the Office of Autism Research Coordination (OARC) and Acclaro Research Solutions, Inc., on behalf of the Interagency Autism Coordinating Committee (IACC), conducted a comprehensive analysis of the 2009 autism spectrum disorder (ASD) research portfolio of major Federal agencies and private organizations. This is the second annual analysis of this nature, following the "2008 IACC Portfolio Analysis Report" released in 2009. The intent of these analyses is to better inform the IACC and interested stakeholders about the funding landscape and current directions for ASD research. Additionally, this analysis examines the extent to which current funding and research topics align with the "2010 IACC Strategic Plan for ASD Research". The "2009 Portfolio Analysis" can also be used by Federal agencies and private research organizations to help guide future funding priorities by outlining current gaps and opportunities in ASD research, as well as serving to highlight current activities and research progress. Findings reveal that total funding for ASD research from all participating agencies and organizations increased by 41% between 2008 ($222,215,342) and 2009 ($314,385,374). This is the result of a 65% increase in Federal spending ($93,701,880) and a 2% decrease ($1,531,848) in private funding between 2008 and 2009. NIH-ARRA funds provided a substantial boost to ASD research funding in 2009, but even without ARRA funding, total Federal investment increased 21% from 2008 ($143,724,845) to 2009 ($173,457,733). Of the 995 ASD research projects funded in 2009, $123,574,025 (39%) and 348 (35%) of those projects were newly established. Appended are: (1) ASD Research Progress on "IACC Strategic Plan Objectives"; (2) Interagency Autism Coordinating Committee Member Roster; and (3) Office of Autism Research Coordination Staff Roster. (Contains 3 tables, 8 figures and 2 footnotes.) [This report was prepared by the Office of Autism Research Coordination and Acclaro Research Solutions, Inc.] Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 41 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - American Recovery and Reinvestment Act 2009 KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - At Risk Persons KW - Etiology KW - Clinical Diagnosis KW - Federal Aid KW - Private Financial Support KW - Pervasive Developmental Disorders KW - Intervention KW - Adults KW - Portfolios (Background Materials) KW - Federal Legislation KW - Public Agencies KW - Research Needs KW - Access to Information KW - Access to Health Care KW - Guides KW - Research KW - Autism KW - Strategic Planning KW - Private Agencies KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964172569?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Introduction of the quality documentation requirements on investigational new drug applications for phase 1 studies of drugs in FDA and EMA AN - 923201163; 15369825 AB - Guidelines on the requirements to the pharmaceutical quality documentation of investigational medicinal products in clinical trials are issued by FDA and EMA. In this paper, we discribed main contents of the quality documentation requirements concerning investigational new drug applications for phase 1 studies of drugs. It would like to work a source of inspiration, and will help expedite entry of new drugs into clinical testing. JF - Zhongguo Linchuang Yaolixue Zazhi - The Chinese Journal of Clinical Pharmacology AU - Yu, H AU - Ma, Y N AD - Center for Drug Evaluation, State Food and Drug Administration, Beijing 100038, China, yuh@cde.org.cn Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 476 EP - 480 VL - 27 IS - 6 SN - 1001-6821, 1001-6821 KW - Biotechnology and Bioengineering Abstracts KW - Pharmaceuticals KW - Drugs KW - Clinical trials KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923201163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.atitle=Introduction+of+the+quality+documentation+requirements+on+investigational+new+drug+applications+for+phase+1+studies+of+drugs+in+FDA+and+EMA&rft.au=Yu%2C+H%3BMa%2C+Y+N&rft.aulast=Yu&rft.aufirst=H&rft.date=2011-06-01&rft.volume=27&rft.issue=6&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.issn=10016821&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Pharmaceuticals; Clinical trials; Drugs ER - TY - JOUR T1 - Theoretical framework for quantitatively estimating ultrasound beam intensities using infrared thermography AN - 923194858; 15220479 AB - In the characterization of high-intensity focused ultrasound (HIFU) systems, it is desirable to know the intensity field within a tissue phantom. Infrared (IR) thermography is a potentially useful method for inferring this intensity field from the heating pattern within the phantom. However, IR measurements require an air layer between the phantom and the camera, making inferences about the thermal field in the absence of the air complicated. For example, convection currents can arise in the air layer and distort the measurements relative to the phantom-only situation. Quantitative predictions of intensity fields based upon IR temperature data are also complicated by axial and radial diffusion of heat. In this paper, mathematical expressions are derived for use with IR temperature data acquired at times long enough that noise is a relatively small fraction of the temperature trace, but small enough that convection currents have not yet developed. The relations were applied to simulated IR data sets derived from computed pressure and temperature fields. The simulation was performed in a finite-element geometry involving a HIFU transducer sonicating upward in a phantom toward an air interface, with an IR camera mounted atop an air layer, looking down at the heated interface. It was found that, when compared to the intensity field determined directly from acoustic propagation simulations, intensity profiles could be obtained from the simulated IR temperature data with an accuracy of better than 10%, at pre-focal, focal, and post-focal locations. JF - Journal of the Acoustical Society of America AU - Myers, M R AU - Giridhar, D AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10993 New Hampshire Avenue, Silver Spring, Maryland 20993, USA, matthew.myers@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 4073 EP - 4083 PB - Acoustical Society of America, Suite 1NO1 2 Huntington Quadrangle Melville NY 11747-4502 United States VL - 129 IS - 6 SN - 0001-4966, 0001-4966 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Convection KW - Data processing KW - Mathematical models KW - Acoustics KW - Cameras KW - Diffusion KW - Thermography KW - Pressure KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923194858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Theoretical+framework+for+quantitatively+estimating+ultrasound+beam+intensities+using+infrared+thermography&rft.au=Myers%2C+M+R%3BGiridhar%2C+D&rft.aulast=Myers&rft.aufirst=M&rft.date=2011-06-01&rft.volume=129&rft.issue=6&rft.spage=4073&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/10.1121%2F1.3575600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Convection; Temperature effects; Mathematical models; Data processing; Acoustics; Cameras; Diffusion; Pressure; Thermography; Ultrasound DO - http://dx.doi.org/10.1121/1.3575600 ER - TY - JOUR T1 - Replication of the Primary Dog Kidney-53 Dengue 2 Virus Vaccine Candidate in Aedes aegypti Is Modulated by a Mutation in the 5' Untranslated Region and Amino Acid Substitutions in Nonstructural Proteins 1 and 3 AN - 920796791; 16154956 AB - Previous studies have demonstrated reduced replication of the cell culture-adapted Dengue-2 virus (DENV-2) vaccine candidate, primary dog kidney (PDK)-53, compared with the parental DENV-2 strain, 16681, in C6/36 cells. Various DENV-2 mutants incorporating PDK-53 substitutions singly and in combination into the 16681 genetic backbone were used to identify the genetic basis for impaired replication of the vaccine candidate in vitro in Aedes aegypti cell culture (Aag2 cells) as well as the reduced in vivo infectivity and transmissibility within Ae. aegypti infected by intrathoracic inoculation. 5' untranslated region (UTR-c57t) and nonstructural protein 1 (NS1-G53D) mutations were required to completely attenuate in vitro replication. In contrast, incorporation of the PDK-53-specific NS3-250V mutation into the 16681 virus resulted in reduced replication in mosquitoes but had no effect on In vitro replication. Further, reversion of the PDK-53 NS3-250 site to that of the wild-type 16681 virus (NS3-V250E) failed to increase either in vitro or in vivo replication. Intrathoracic inoculation of Ae. aegypti with mutants containing the PDK-53 NS1 substitution exhibited in vivo replication indistinguishable from the parental PDK-53 virus, implicating this mutation as the dominant determinant for impaired mosquito replication of the PDK-53 candidate; however, further attenuation of in vivo replication was magnified in mutants including the additional 5'UTR-c57t mutation. JF - Vector Borne and Zoonotic Diseases AU - Brault, A C AU - Kinney, R M AU - Maharaj, P D AU - Green, ENG AU - Reisen, W K AU - Huang, CY-H AD - Division of Vector-Borne Infectious Diseases, U. S. Department of Health and Human Services, Centers for Disease Control and Prevention, Foothills Campus/Rampart Road, Fort Collins, CO 80521, USA, abrault@cdc.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 683 EP - 689 VL - 11 IS - 6 SN - 1530-3667, 1530-3667 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts; Virology & AIDS Abstracts KW - Aedes aegypti KW - Human diseases KW - Amino acid substitution KW - Amino acids KW - Replication KW - Mutations KW - Disease control KW - Vectors KW - Reversion KW - Cell culture KW - Public health KW - Disease transmission KW - Infectivity KW - Nonstructural proteins KW - Inoculation KW - Kidney KW - Vaccines KW - Dengue virus type 2 KW - Mutation KW - Aquatic insects KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - V 22320:Replication KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920796791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Replication+of+the+Primary+Dog+Kidney-53+Dengue+2+Virus+Vaccine+Candidate+in+Aedes+aegypti+Is+Modulated+by+a+Mutation+in+the+5%27+Untranslated+Region+and+Amino+Acid+Substitutions+in+Nonstructural+Proteins+1+and+3&rft.au=Brault%2C+A+C%3BKinney%2C+R+M%3BMaharaj%2C+P+D%3BGreen%2C+ENG%3BReisen%2C+W+K%3BHuang%2C+CY-H&rft.aulast=Brault&rft.aufirst=A&rft.date=2011-06-01&rft.volume=11&rft.issue=6&rft.spage=683&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2010.0150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Human diseases; Amino acids; Mutations; Replication; Disease control; Vaccines; Aquatic insects; Disease transmission; Public health; Infectivity; Amino acid substitution; Nonstructural proteins; Kidney; Inoculation; Reversion; Vectors; Cell culture; Mutation; Aedes aegypti; Dengue virus type 2 DO - http://dx.doi.org/10.1089/vbz.2010.0150 ER - TY - JOUR T1 - A Relative Standard for Minimal Risk is Unnecessary and Potentially Harmful to Children: Lessons from the Phambili Trial AN - 918051958; 15136571 JF - American Journal of Bioethics AU - Nelson, Robert M AD - U.S. Food and Drug Administration, Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 14 EP - 16 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 11 IS - 6 SN - 1526-5161, 1526-5161 KW - Environment Abstracts KW - Children KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918051958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Bioethics&rft.atitle=A+Relative+Standard+for+Minimal+Risk+is+Unnecessary+and+Potentially+Harmful+to+Children%3A+Lessons+from+the+Phambili+Trial&rft.au=Nelson%2C+Robert+M&rft.aulast=Nelson&rft.aufirst=Robert&rft.date=2011-06-01&rft.volume=11&rft.issue=6&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Bioethics&rft.issn=15265161&rft_id=info:doi/10.1080%2F15265161.2011.568588 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Children DO - http://dx.doi.org/10.1080/15265161.2011.568588 ER - TY - JOUR T1 - Detection of aacA-aphD, qacE[delta]1, marA, floR, and tetA genes from multidrug-resistant bacteria: Comparative analysis of real-time multiplex PCR assays using EvaGreen[super][registered] and SYBR[super][registered] Green I dyes AN - 904474294; 14818988 AB - We have developed multiplex real-time PCR assays that utilize DNA-intercalating dyes, SYBR Green I (SG) and EvaGreen (EG), with two primer sets (set 1 = qacE[delta]1, tetA and aacA-aphD; set 2 = tetA, marA, and floR) to simultaneously amplify the qacE[delta]1, tetA, aacA-aphD, marA, and floR genes. Validity of the multiplex PCR assays was confirmed by testing 83 bacterial isolates, including Staphylococcus aureus (28 isolates), Enterococcus spp. (17 isolates), Salmonella enterica serovar Typhimurium (8 isolates), Citrobacter spp. (9 isolates), Escherichia coli (14 isolates) and Aeromonas veronii (7 isolates), and performing sequence analysis of representative PCR products. Agarose gel analysis revealed the presence of correct size PCR products, and the differences in their thermal melting (T sub(m) curves were used to distinguish various PCR products. Although T) sub(m) peaks of different amplicons after EG-based singleplex and multiplex PCR assays were resolved nicely, only one or two peaks were seen for SG-bound amplicons. EG-based multiplex real-time PCR assays provided better peak resolution. There was a good correlation with a better linear relationship between the C sub(t and log input DNA concentration for the set 1 and set 2 genes in EG-based assays [inline image] than in SG-based assays [inline image]. The sensitivities of detection were 2.5-25 fg and 25-250 fg of template DNA in EG and SG-based singleplex and multiplex PCR assays, respectively. The assays, which could be completed in less than 45 min, offer sensitive and rapid detection of qacE[delta]1, aacA-aphD, marA, floR, and tetA genes from a diverse group of multiple antibiotic-resistant bacterial strains.) JF - Molecular and Cellular Probes AU - Khan, Saeed A AU - Sung, Kidon AU - Nawaz, Mohamed S AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR 72079, United States, saeed.khan@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 78 EP - 86 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 25 IS - 2-3 SN - 0890-8508, 0890-8508 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Dyes KW - Polymerase chain reaction KW - Primers KW - Probes KW - Aeromonas veronii KW - Citrobacter KW - Salmonella enterica KW - Enterococcus KW - Escherichia coli KW - Staphylococcus aureus KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Detection+of+aacA-aphD%2C+qacE%5Bdelta%5D1%2C+marA%2C+floR%2C+and+tetA+genes+from+multidrug-resistant+bacteria%3A+Comparative+analysis+of+real-time+multiplex+PCR+assays+using+EvaGreen%5Bsuper%5D%5Bregistered%5D+and+SYBR%5Bsuper%5D%5Bregistered%5D+Green+I+dyes&rft.au=Khan%2C+Saeed+A%3BSung%2C+Kidon%3BNawaz%2C+Mohamed+S&rft.aulast=Khan&rft.aufirst=Saeed&rft.date=2011-06-01&rft.volume=25&rft.issue=2-3&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2011.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Dyes; Drug resistance; Probes; Polymerase chain reaction; Primers; Salmonella enterica; Citrobacter; Aeromonas veronii; Enterococcus; Escherichia coli; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.mcp.2011.01.004 ER - TY - JOUR T1 - Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques AN - 904474286; 14818986 AB - Mycoplasmas, particularly species of the genera Mycoplasma and Acholeplasma, are known to be occasional microbial contaminants of cell cultures that produce biologics. This presents a serious concern regarding the risk of mycoplasma contamination for research laboratories and commercial facilities developing and manufacturing cell-derived biological and biopharmaceutical products for therapeutic use. Potential undetected contamination of these products or process intermediates with mycoplasmas represents a potential safety risk for patients and a business risk for producers of biopharmaceuticals. To minimize these risks, monitoring for adventitious agents, such as viruses and mycoplasmas, is performed during the manufacture of biologics produced in cell culture substrates. The "gold standard" microbiological assay, currently recommended by the USP, EP, JP and the US FDA, for the mycoplasma testing of biologics, involves the culture of viable mycoplasmas in broth, agar plates and indicator cells. Although the procedure enables highly efficient mycoplasma detection in cell substrates and cell-derived products, the overall testing strategy is time consuming (a minimum of 28 days) and requires skilled interpretation of the results. The long time period required for these conventional assays does not permit their use for products with short shelf-lives or for timely 'go/no-go' decisions during routine in-process testing. PCR methodology has existed for decades, however PCR based and other alternative methods for mycoplasma detection have only recently been considered for application to biologics manufacture. The application of alternative nucleic acid-based, enzyme-based and/or recombinant cell-culture methods, particularly in combination with efficient sample preparation procedures, could provide advantages over conventional microbiological methods in terms of analytical throughput, simplicity, and turnaround time. However, a challenge to the application of alternative methods for detection of mycoplasmas remains whether these alternative methods can provide a limit of detection comparable or superior to those of the culture methods. An additional challenge is that nucleic acid amplification technique (NAT) methods do not allow for accurate discrimination between viable and non-viable mycoplasma contaminants, which might lead to false-positive results (e.g. from inactivated raw materials, etc.). Our review provides an overview of these alternative methods and discusses the pros and cons of their application for the testing of mycoplasmas in biologics and cell substrates. JF - Molecular and Cellular Probes AU - Volokhov, Dmitriy V AU - Graham, Laurie J AU - Brorson, Kurt A AU - Chizhikov, Vladimir E AD - U.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Office of Vaccine Research and Review, Division of Viral Products, Laboratory of Methods Development, HFM-470, 1401 Rockville Pike, Rockville, MD 20852, USA, dmitriy.volokhov@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 69 EP - 77 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 25 IS - 2-3 SN - 0890-8508, 0890-8508 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - nucleic acids KW - Contamination KW - Reviews KW - Acholeplasma KW - Probes KW - Pharmaceuticals KW - Polymerase chain reaction KW - Cell culture KW - Contaminants KW - Mycoplasma KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Probes&rft.atitle=Mycoplasma+testing+of+cell+substrates+and+biologics%3A+Review+of+alternative+non-microbiological+techniques&rft.au=Volokhov%2C+Dmitriy+V%3BGraham%2C+Laurie+J%3BBrorson%2C+Kurt+A%3BChizhikov%2C+Vladimir+E&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2011-06-01&rft.volume=25&rft.issue=2-3&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Probes&rft.issn=08908508&rft_id=info:doi/10.1016%2Fj.mcp.2011.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Agar; nucleic acids; Contamination; Reviews; Probes; Polymerase chain reaction; Pharmaceuticals; Cell culture; Contaminants; Acholeplasma; Mycoplasma DO - http://dx.doi.org/10.1016/j.mcp.2011.01.002 ER - TY - JOUR T1 - Factorial Invariance, Scale Reliability, and Construct Validity of the Job Control and Job Demands Scales for Immigrant Workers: The Multi-Ethnic Study of Atherosclerosis AN - 896187373; 201116792 AB - Immigrants have a different social context from those who stay in their home country or those who were born to the country that immigrants now live. Cultural theory of risk perception suggests that social context influences one's interpretation of questionnaire items. We examined psychometric properties of job control and job demand scales with US- and foreign-born workers who preferred English, Spanish, or Chinese (n=3,114, mean age=58.1). Across all groups, the job control scale had acceptable Cronbach's alpha (0.78-0.83) and equivalent factor loadings (DCFI<0.01). Immigrants had low alpha (0.42-0.65) for the job demands scale regardless of language, education, or age of migration. Two job-demand items had different factor loadings across groups. Among immigrants, both scales had inconsistent associations with perceived job stress and self-rated health. For a better understanding of immigrants' job stress, the concept of job demands should be expanded and immigrants' expectations for job control explored. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Fujishiro, Kaori AU - Landsbergis, Paul A AU - Diez-Roux, Ana V AU - Stukovsky, Karen Hinckley AU - Shrager, Sandi AU - Baron, Sherry AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy (R-15), Cincinnati, OH, 45226, USA kfujishiro@cdc.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 533 EP - 540 PB - Springer, Dordrecht The Netherlands VL - 13 IS - 3 SN - 1557-1912, 1557-1912 KW - Social context KW - Job characteristics KW - Job control KW - Immigrants KW - Occupational stress KW - Migration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896187373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Factorial+Invariance%2C+Scale+Reliability%2C+and+Construct+Validity+of+the+Job+Control+and+Job+Demands+Scales+for+Immigrant+Workers%3A+The+Multi-Ethnic+Study+of+Atherosclerosis&rft.au=Fujishiro%2C+Kaori%3BLandsbergis%2C+Paul+A%3BDiez-Roux%2C+Ana+V%3BStukovsky%2C+Karen+Hinckley%3BShrager%2C+Sandi%3BBaron%2C+Sherry&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2011-06-01&rft.volume=13&rft.issue=3&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-010-9364-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Immigrants; Job control; Job characteristics; Social context; Occupational stress; Migration DO - http://dx.doi.org/10.1007/s10903-010-9364-2 ER - TY - JOUR T1 - Confirmatory factor analysis and factorial invariance analysis of the adolescent self-report Strengths and Difficulties Questionnaire: how important are method effects and minor factors? AN - 892943937; 4232783 AB - Objectives. This study examined the factor structure of the self-report Strengths and Difficulties Questionnaire, ping special attention to the number of factors and to negative effects of reverse-worded items and minor factors within the subscales on model fit. Furthermore, factorial invariance across gender, age, level of education, and ethnicity was investigated. Design. Data were obtained from the Youth Health Monitor Rotterdam, a community-based health surveillance system. Methods. The sample consisted of 11,881 pupils of 11-16 years old. Next to the original five-factor model, a factor model with the number of factors based on parallel analysis and scree test was investigated. Confirmatory factor analysis for ordered-categorical measures was applied to examine the goodness-of-fit and factorial invariance of the factor models. Results. After allowing reverse-worded items to cross-load on the prosocial behaviour factor and adding error correlations, a good fit to the data was found for the original five-factor model (emotional symptoms, conduct problems, hyperactivity-inattention, peer problems, prosocial behaviour) and a model with four factors (emotional symptoms and peer problems, conduct problems, hyperactivity-inattention, prosocial behaviour). Factorial invariance across gender, age, level of education, and ethnicity was found for the final five- and four-factor model, except for the prosocial factor of the four-factor model that showed partial invariance across gender. Conclusions. While support was found for both models, the final five-factor model is theoretically more plausible and gained additional support as the original scales emotional problems and peer problems showed different relations with gender, educational level, and ethnicity. Adapted from the source document. Reprinted by permission of the British Psychological Society JF - British journal of clinical psychology AU - Looij-Jansen, Petra M. van de AU - Goedhart, Arnold W AU - de Wilde, Erik J AU - Treffers, Philip D.A. AD - Municipal Public Health Service, Rotterdam Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 127 EP - 144 VL - 50 IS - 2 SN - 0144-6657, 0144-6657 KW - Sociology KW - Questionnaires KW - Research methods KW - Ethnicity KW - Factor analysis KW - Level of education KW - Gender KW - Adolescents KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892943937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+clinical+psychology&rft.atitle=Confirmatory+factor+analysis+and+factorial+invariance+analysis+of+the+adolescent+self-report+Strengths+and+Difficulties+Questionnaire%3A+how+important+are+method+effects+and+minor+factors%3F&rft.au=Looij-Jansen%2C+Petra+M.+van+de%3BGoedhart%2C+Arnold+W%3Bde+Wilde%2C+Erik+J%3BTreffers%2C+Philip+D.A.&rft.aulast=Looij-Jansen&rft.aufirst=Petra+M.+van&rft.date=2011-06-01&rft.volume=50&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=British+journal+of+clinical+psychology&rft.issn=01446657&rft_id=info:doi/10.1348%2F014466510X498174 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4722 12224 971; 593; 10541; 10919; 8163; 5421 6091; 7353 4049; 4435 DO - http://dx.doi.org/10.1348/014466510X498174 ER - TY - JOUR T1 - Barriers to Managing Diabetes During Pregnancy: The Perceptions of Health Care Practitioners AN - 879477147; 14887454 AB - Abstract: Background: Uncontrolled pregestational diabetes in pregnancy is associated with an increased risk for a major birth defect and additional adverse pregnancy outcomes. The study objective was to investigate the concerns of health care practitioners who care for women with a history of diabetes during pregnancy and their perceptions of attitudes and barriers to achieving good glycemic control. Methods: Focus groups were conducted with physicians, midlevel practitioners, and certified diabetes educators in Atlanta, Georgia. Practitioners were eligible if they actively practiced, primarily in outpatient facilities in Atlanta, and were neither students nor interns. Six focus groups, two of each practitioner type, were conducted. Results: Practitioners stated that few of their patients planned their pregnancies. Practitioners perceived that pregnant women were concerned primarily about their babies and might not be aware of complications with their personal health. Their perceptions of the greatest barriers to glycemic control for women involved lack of knowledge, lack of access, and attitude. Conclusions: Educating women with diabetes about the importance of using effective birth control until they have achieved good glycemic control can help reduce the risk for adverse pregnancy outcomes. Motivators and barriers for a woman with diabetes to achieve glycemic control before, during, and after pregnancy should be considered when developing approaches to improve outcomes. Helping practitioners know what and how to address the needs of childbearing women with or at risk for diabetes can be beneficial. Additional efforts to increase women's knowledge about diabetes and pregnancy and to develop effective strategies to encourage women's achievement and maintenance of glycemic control before, during, and after pregnancy are needed. (BIRTH 38:2 June 2011) JF - Birth AU - Mersereau, Patricia AU - Williams, Jennifer AU - Collier, Sarah A AU - Mulholland, Celene AU - Turay, Khadija AU - Prue, Christine AD - Patricia Mersereau is a Health Communication Specialist with SciMetrika, L.L.C., for the U.S. Centers for Disease Control and Prevention (CDC), National Center on Birth Defects and Developmental Disabilities (NCBDDD); Jennifer Williams is a Commander in the U.S. Public Health Service and a Nurse Epidemiologist at CDC, NCBDDD; Sarah Collier is an Analytic Epidemiologist with Atlanta Research and Education Foundation for CDC, National Center for Emerging and Zoonotic Infectious Diseases (NCZVED); Celine Mulholland is a Medical Student at the University of California, Los Angeles, California; Khadija Turay is a Doctoral Candidate at the University of North Carolina at Chapel Hill, North Carolina; Christine Prue is Associate Director for Behavioral Science (Acting), CDC, NCZVED, Atlanta, Georgia, United States of America. Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 142 EP - 149 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 38 IS - 2 SN - 0730-7659, 0730-7659 KW - Risk Abstracts KW - Congenital defects KW - Health care KW - Maintenance KW - Perception KW - Pregnancy KW - attitudes KW - complications KW - diabetes mellitus KW - risk reduction KW - USA, Georgia, Atlanta KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879477147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth&rft.atitle=Barriers+to+Managing+Diabetes+During+Pregnancy%3A+The+Perceptions+of+Health+Care+Practitioners&rft.au=Mersereau%2C+Patricia%3BWilliams%2C+Jennifer%3BCollier%2C+Sarah+A%3BMulholland%2C+Celene%3BTuray%2C+Khadija%3BPrue%2C+Christine&rft.aulast=Mersereau&rft.aufirst=Patricia&rft.date=2011-06-01&rft.volume=38&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Birth&rft.issn=07307659&rft_id=info:doi/10.1111%2Fj.1523-536X.2010.00464.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - risk reduction; diabetes mellitus; complications; Health care; Perception; Congenital defects; Maintenance; attitudes; Pregnancy; USA, Georgia, Atlanta DO - http://dx.doi.org/10.1111/j.1523-536X.2010.00464.x ER - TY - JOUR T1 - General Principles of Medical Surveillance Implications for Workers Potentially Exposed to Nanomaterials AN - 876243272; 15112460 AB - Objective: As potential occupational exposure to nanomaterials becomes more prevalent, it is important that the principles of medical surveillance be considered for workers in the nanotechnology industry. Methods: The principles of medical surveillance are reviewed to further the discussion of occupational health surveillance for workers exposed to nanomaterials. Results: Because of the rapid evolution of nanotechnology, information may not be available to make a well-informed determination of all factors needed to evaluate risk of health effects from occupational exposure to nanomaterials. Conclusion: Every workplace dealing with engineered nanomaterials should conduct hazard and exposure assessments as part of an overall surveillance needs assessment for nanotechnology workers. In workplaces where risk is felt to be present, or at least cannot be ruled out, initiation of medical surveillance is prudent to protect workers' health. JF - Journal of Occupational and Environmental Medicine AU - Trout, D B AD - DSHEFS, NIOSH, R-12, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, dtrout@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S22 EP - S24 VL - 53 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Reviews KW - Occupational exposure KW - nanotechnology KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876243272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=General+Principles+of+Medical+Surveillance+Implications+for+Workers+Potentially+Exposed+to+Nanomaterials&rft.au=Trout%2C+D+B&rft.aulast=Trout&rft.aufirst=D&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S22&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1e45 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Reviews; Occupational exposure; Occupational health; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1e45 ER - TY - JOUR T1 - Overview of Current Toxicological Knowledge of Engineered Nanoparticles AN - 876243251; 15112458 AB - Objective: Nanotechnology is the manipulation of matter on a near-atomic scale to produce nanoparticles with unique properties, allowing new commercial applications. Since nanoparticles exhibit unique physicochemical properties, they are likely to exhibit biological activity significantly different from fine-sized particles of the same chemical composition. Therefore, evaluation of the biological effects of nanoparticles is critical. Methods: The article lists the major objectives of nanotoxicology and briefly reviews the literature concerning biological responses to pulmonary exposure. Results: Interactions of nanoparticles with biological systems depend on particle size, shape, oxidant generation, surface functionalization, and rate of dissolution. Pulmonary, cardiovascular, and central nervous system responses to pulmonary exposure to nanotitanium dioxide and carbon nanotubes are described. Conclusions: Significant biological responses occur in animal models after pulmonary exposure to certain nanoparticles. Control of exposure appears prudent to protect worker health. Clinical Significance: Nanotechnology is synthesizing a wide range of nanoparticles, which exhibit unique physicochemical properties. These unique properties make unique biological activity likely. If certain nanoparticles induce adverse effects in vitro or in animal models, then occupational health surveillance and exposure control may be prudent steps in the protection of worker health. JF - Journal of Occupational and Environmental Medicine AU - Castranova, V AD - NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA, vic1@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S14 EP - S17 VL - 53 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Particle size KW - Central nervous system KW - Physicochemical properties KW - Animal models KW - Particulates KW - Carbon KW - Lung KW - Reviews KW - Dissolution KW - nanotubes KW - nanoparticles KW - Oxidants KW - Side effects KW - Occupational exposure KW - nanotechnology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876243251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Overview+of+Current+Toxicological+Knowledge+of+Engineered+Nanoparticles&rft.au=Castranova%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S14&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1e5a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Central nervous system; Physicochemical properties; Animal models; Carbon; Lung; Reviews; nanotubes; Dissolution; nanoparticles; Occupational exposure; Side effects; Oxidants; nanotechnology; Particle size; Particulates DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1e5a ER - TY - JOUR T1 - Nanomaterials and Worker Health Medical Surveillance, Exposure Registries, and Epidemiologic Research AN - 876243230; 15112456 AB - Objective: This article provides an overview of the issues that arise with medical surveillance, exposure registration, and epidemiologic research involving nanomaterial workers. Methods: An occupational health perspective is applied to detecting risks in nanomaterial workers individually and as a group. Results: General principles for medical surveillance, exposure registration, and epidemiologic research are identified. A model Nanomaterial Worker Health Study is for consideration. Conclusions: The Nanomaterial Worker Health Study can be developed as a tangible action in assuring the public that steps are being taken to learn of any adverse effects from exposure to nanomaterials. JF - Journal of Occupational and Environmental Medicine AU - Schulte, P A AU - Trout, D B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA, PSchulte@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S3 EP - S7 VL - 53 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Occupational exposure KW - Occupational health KW - Side effects KW - nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876243230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Nanomaterials+and+Worker+Health+Medical+Surveillance%2C+Exposure+Registries%2C+and+Epidemiologic+Research&rft.au=Schulte%2C+P+A%3BTrout%2C+D+B&rft.aulast=Schulte&rft.aufirst=P&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1b28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Side effects; Occupational exposure; Occupational health; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1b28 ER - TY - JOUR T1 - Carbon Nanotube Risk Assessment Implications for Exposure and Medical Monitoring AN - 876239527; 15112475 AB - Objective: Quantitative risk estimates using toxicology data provide information for risk management to protect workers with potential exposure to carbon nanotubes (CNTs). Methods: Dose-response data from subchronic inhalation studies in rats were used in benchmark dose modeling. Dose was airborne mass concentration of multiwalled CNTs. Responses included pulrronary inflammation, lipoproteinosis, and fibrosis. Results: Estimated human-equivalent concentrations to the rat lowest observed adverse effect levels were similar to some workplace airborne concentrations of CNTs. Working lifetime risk estimates of early-stage adverse lung effects were more than 10% at the limit of quantification (7 mu g/m super(3)) of the National Institute for Occupational Safety and Health analytical method for measuring CNT airborne concentrations. Conclusions: Exposure monitoring and control are the primary occupational health measures to protect workers from potential exposure to CNT. Medical monitoring for early detection of occupational respiratory diseases may also be warranted. JF - Journal of Occupational and Environmental Medicine AU - Kuempel, ED AD - Education and Information Division, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, M.S. C-15, Cincinnati, OH 45226, USA, ekuempel@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S91 EP - S97 VL - 53 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Risk assessment KW - Data processing KW - Fibrosis KW - Respiratory diseases KW - Inflammation KW - Rats KW - Carbon KW - benchmarks KW - Lung KW - Dose-response effects KW - Occupational exposure KW - Side effects KW - nanotechnology KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876239527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Carbon+Nanotube+Risk+Assessment+Implications+for+Exposure+and+Medical+Monitoring&rft.au=Kuempel%2C+ED&rft.aulast=Kuempel&rft.aufirst=ED&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1f3f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inhalation; Data processing; Carbon; Lung; Fibrosis; Side effects; Occupational exposure; Inflammation; Rats; benchmarks; Dose-response effects; Respiratory diseases; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1f3f ER - TY - JOUR T1 - Engineered Carbonaceous Nanomaterials Manufacturers in the United States Workforce Size, Characteristics, and Feasibility of Epidemiologic Studies AN - 876237610; 15112470 AB - Objective: Toxicology studies suggest that carbon nanotube (CNT) exposures may cause adverse pulmonary effects. This study identified all US engineered carbonaceous nanomaterial (ECN) manufacturers, determined workforce size and growth, and characterized the materials produced to determine the feasibility of occupational ECN exposure studies. Methods: Eligible companies were identified; information was assembled on the companies and nanomaterials they produced; and the workforce size, location, and growth were estimated. Results: Sixty-one companies manufacturing ECN in the United States were identified. These companies employed at least 620 workers; workforce growth was projected at 15% to 17% annually. Most companies produced or used CNT. Half the eligible companies provided information about material dimensions, quantities, synthesis methods, and worker exposure reduction strategies. Conclusions: Industrywide exposure assessment studies appear feasible; however, cohort studies are likely infeasible because of the small, scattered workforce. JF - Journal of Occupational and Environmental Medicine AU - Schubauer-Berigan, M K AU - Dahm, M M AU - Yencken AD - National Institute for Occupational Safety and Health; Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, MS-R15, Cincinnati, OH 45226, USA, zcg3@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S62 EP - S67 VL - 53 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Feasibility studies KW - USA KW - Occupational exposure KW - Toxicology KW - nanotechnology KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876237610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Engineered+Carbonaceous+Nanomaterials+Manufacturers+in+the+United+States+Workforce+Size%2C+Characteristics%2C+and+Feasibility+of+Epidemiologic+Studies&rft.au=Schubauer-Berigan%2C+M+K%3BDahm%2C+M+M%3BYencken&rft.aulast=Schubauer-Berigan&rft.aufirst=M&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S62&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1e2c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Feasibility studies; Toxicology; Occupational exposure; nanotechnology; USA DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1e2c ER - TY - JOUR T1 - Height at diagnosis and birth-weight as risk factors for osteosarcoma AN - 876237570; 14895520 AB - Objectives : Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma. Methods: Patient data from seven studies of height and three of birth-weight were obtained, resulting in 1,067 cases with height and 434 cases with birth-weight data. We compared cases to the 2000 US National Center for Health Statistics Growth Charts by simulating 1,000 age- and gender-matched controls per case. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between height or birth-weight and risk of osteosarcoma for each study were estimated using logistic regression. All of the case data were combined for an aggregate analysis. Results: Compared to average birth-weight subjects (2,665-4,045g), individuals with high birth-weight ( greater than or equal to 4,046g) had an increased osteosarcoma risk (OR 1.35, 95% CI 1.01-1.79). Taller than average (51st-89th percentile) and very tall individuals ( greater than or equal to 90th percentile) had an increased risk of osteosarcoma (OR 1.35, 95% CI 1.18-1.54 and OR 2.60, 95% CI 2.19-3.07, respectively; P sub(trend)<0.0001). Conclusions: This is the largest analysis of height at diagnosis and birth-weight in relation to osteosarcoma. It suggests that rapid bone growth during puberty and in utero contributes to OS etiology. JF - Cancer Causes & Control AU - Mirabello, Lisa AU - Pfeiffer, Ruth AU - Murphy, Gwen AU - Daw, Najat C AU - Patino-Garcia, Ana AU - Troisi, Rebecca J AU - Hoover, Robert N AU - Douglass, Chester AU - Schuz, Joachim AU - Craft, Alan W AU - Savage, Sharon A AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, mirabellol@mail.nih.gov mirabellol@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 899 EP - 908 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 6 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Bone KW - Etiology KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876237570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Height+at+diagnosis+and+birth-weight+as+risk+factors+for+osteosarcoma&rft.au=Mirabello%2C+Lisa%3BPfeiffer%2C+Ruth%3BMurphy%2C+Gwen%3BDaw%2C+Najat+C%3BPatino-Garcia%2C+Ana%3BTroisi%2C+Rebecca+J%3BHoover%2C+Robert+N%3BDouglass%2C+Chester%3BSchuz%2C+Joachim%3BCraft%2C+Alan+W%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=899&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9763-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bone; Etiology; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9763-2 ER - TY - JOUR T1 - Exposure Registries: Overview and Utility for Nanomaterial Workers AN - 876235417; 15112466 AB - Objective: This article provides the background for consideration of exposure registries to address potential disease risks in nanomaterial workers. Methods: The history of exposure registries is reviewed with a focus on their purpose and criteria for establishment. Results: A rationale is presented for developing registries of nanomaterial workers, and unresolved obstacles and challenges are identified. These include issues on inclusion criteria, funding, potential for legal risks, access to data, confidentiality of business information, privacy, and workers' expectations. Conclusion: If society is to gain the benefits from nanotechnology, it must take precautions and demonstrate care for those, such as workers, who may be most at risk of adverse effects. Establishing exposure registries is a part of such a precautionary and caring approach. JF - Journal of Occupational and Environmental Medicine AU - Schulte, P A AU - Mundt, D J AU - Nasterlack, M AU - Mulloy, K B AU - Mundt, KA AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, Ohio 45226, USA, PSchulte@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S42 EP - S47 VL - 53 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Reviews KW - Occupational exposure KW - Side effects KW - nanotechnology KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876235417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Exposure+Registries%3A+Overview+and+Utility+for+Nanomaterial+Workers&rft.au=Schulte%2C+P+A%3BMundt%2C+D+J%3BNasterlack%2C+M%3BMulloy%2C+K+B%3BMundt%2C+KA&rft.aulast=Schulte&rft.aufirst=P&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S42&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821aebed LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Historical account; Reviews; Side effects; Occupational exposure; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e31821aebed ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. Part 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans AN - 876232924; 14946444 AB - A new synthesis of N-methyl and N-phenethyl substituted ortho-c and para-c oxide-bridged phenylmorphans, using N-benzyl- rather than N-methyl-substituted intermediates, was used and the pharmacological properties of these compounds were determined. The N-phenethyl substituted ortho-c oxide-bridged phenylmorphan(rac-(3R,6aS,11aS)-2-phenethyl-2,3,4,5,6,11a-hexahydr o -1H-3,6a-methanobenzofuro[2,3-c]azocin-10-ol ( 12)) was found to have the highest [micro]-opioid receptor affinity (K sub(i = 1.1 nM) of all of the a- through f-oxide-bridged phenylmorphans. Functional data ([[super]35S]GTP- gamma -S) showed that the racemate 12 was more than three times more potent than naloxone as an [micro]-opioid antagonist. AB:) JF - Bioorganic and Medicinal Chemistry AU - Kim, Jin-Hee AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Folk, John E AU - Cheng, Kejun AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 3434 EP - 3443 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 19 IS - 11 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Antibodies KW - Data processing KW - Probes KW - Naloxone KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876232924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+Part+42%3A+Synthesis+and+in+vitro+pharmacological+characterization+of+the+N-methyl+and+N-phenethyl+analogues+of+the+racemic+ortho-c+and+para-c+oxide-bridged+phenylmorphans&rft.au=Kim%2C+Jin-Hee%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BFolk%2C+John+E%3BCheng%2C+Kejun%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Kim&rft.aufirst=Jin-Hee&rft.date=2011-06-01&rft.volume=19&rft.issue=11&rft.spage=3434&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2011.04.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Antibodies; Data processing; Probes; Naloxone DO - http://dx.doi.org/10.1016/j.bmc.2011.04.028 ER - TY - JOUR T1 - Consumer Response to a National Marketplace for Individual Health Insurance AN - 876231705; 14889196 AB - The objective of this analysis is to simulate the difference between national and state-specific individual insurance markets on take-up of individual health insurance. This simulation analysis was completed in three steps. First, we reviewed the literature to characterize the state-specific individual insurance markets with respect to state regulations and to identify the effect of those regulations on health insurance premiums. Second, we used empirical data to develop premium estimates for the simulation that reflect case-mix as well as state-specific differences in health care markets. Third, we used a revised version of the 2005 Medical Expenditure Panel Survey (MEPS) to complete a set of simulations to identify the impact of three different scenarios for national market development. (National market estimates are based on the simulation model with competition among all 50 states and moderate impact assumptions.) We find evidence of a significant opportunity to reduce the number of uninsured under a proposal to allow the purchase of health insurance across state lines. The best scenario to reduce the uninsured, numerically, is competition among all 50 states with one clear winner. The most pragmatic scenario, with a good impact, is one winner in each regional market. JF - Journal of Risk and Insurance AU - Parente, Stephen T AU - Feldman, Roger AU - Abraham, Jean AU - Xu, Yi AD - Stephen T. Parente is at the Carlson School of Management, University of Minnesota. Roger Feldman, Jean Abraham, and Yi Xu are at the School of Public Health, University of Minnesota. The authors can be contacted via e-mail: sparente super(m)n.edu, feldm002 super(m)n.edu, abrah042 super(m)n.edu, and xuxxx211 super(m)n.edu, respectively. This research was supported by Contract HP-07-024 from the Office of the Assistant Secretary of the Department of Health and Human Services (DHHS). The findings and opinions expressed in the article are solely those of the authors and do not represent DHHS policy. Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 389 EP - 411 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 78 IS - 2 SN - 0022-4367, 0022-4367 KW - Risk Abstracts KW - Health care KW - Insurance KW - Reviews KW - Simulation KW - State regulations KW - competition KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Risk+and+Insurance&rft.atitle=Consumer+Response+to+a+National+Marketplace+for+Individual+Health+Insurance&rft.au=Parente%2C+Stephen+T%3BFeldman%2C+Roger%3BAbraham%2C+Jean%3BXu%2C+Yi&rft.aulast=Parente&rft.aufirst=Stephen&rft.date=2011-06-01&rft.volume=78&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+Risk+and+Insurance&rft.issn=00224367&rft_id=info:doi/10.1111%2Fj.1539-6975.2010.01393.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 2 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - State regulations; Health care; Reviews; Simulation; Insurance; competition DO - http://dx.doi.org/10.1111/j.1539-6975.2010.01393.x ER - TY - JOUR T1 - Baseline Serum Cardiac Troponin I Concentrations in Sprague-Dawley, Spontaneous Hypertensive, Wistar, Wistar-Kyoto, and Fisher Rats as Determined with an Ultrasensitive Immunoassay AN - 876231216; 15070687 AB - Cardiac troponins have proved to be reliable blood biomarkers for identifying a variety of myocardial alterations in humans and animals. Recently, an ultrasensitive cTnI assay (Erenna IA) has been used to demonstrate increases in baseline cTnI resulting from drug-induced myocardial injury in rats, dogs, and monkeys, as well as to document baseline cTnI ranges in Sprague-Dawley (SD) rats. The present study was initiated to use the Erenna cTnI assay to further document baseline cTnI concentrations in normal control animals from multiple strains, including SD, Spontaneous Hypertensive (SHR), Wistar, Wistar-Kyoto (WKY), and Fisher strains. Baseline cTnI concentrations were quantified in all rats tested, and males had higher mean cTnI concentrations than females of the same strain. SHR males had the highest mean cTnI concentrations and the largest cTnI variability. Interestingly, cTnI concentrations increased in castrated SHR compared with unaltered male SHR, whereas cTnI concentrations decreased in ovariectomized SHR compared with unaltered female SHR. These results show significant differences in cTnI concentrations between strains, sexes, and noncardiac surgical alterations in control animals, and identify these as potential contributing factors to cTnI baseline variability that should be taken into account when using ultrasensitive cTnI as a biomarker to assess preclinical cardiotoxicity. JF - Toxicologic Pathology AU - Herman, Eugene AU - Knapton, Alan AU - Rosen, Elliot AU - Zhang, Jun AU - Estis, Joel AU - Agee, Sara J AU - Lu, Quynh-Anh AU - Todd, John A AU - Lipshultz, Steven E AD - Food and Drug Administration, Division of Applied Pharmacology Research, Silver Spring, Maryland, USA, Eugene.Herman@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 653 EP - 663 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - rat KW - cardiac troponin KW - myocardial injury KW - cardiotoxicity KW - immunoassay KW - single-molecule counting KW - Heart KW - Blood KW - Injuries KW - Ovariectomy KW - Troponin I KW - biomarkers KW - Immunoassays KW - Calcium-binding protein KW - Menopause KW - Sex KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876231216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Baseline+Serum+Cardiac+Troponin+I+Concentrations+in+Sprague-Dawley%2C+Spontaneous+Hypertensive%2C+Wistar%2C+Wistar-Kyoto%2C+and+Fisher+Rats+as+Determined+with+an+Ultrasensitive+Immunoassay&rft.au=Herman%2C+Eugene%3BKnapton%2C+Alan%3BRosen%2C+Elliot%3BZhang%2C+Jun%3BEstis%2C+Joel%3BAgee%2C+Sara+J%3BLu%2C+Quynh-Anh%3BTodd%2C+John+A%3BLipshultz%2C+Steven+E&rft.aulast=Herman&rft.aufirst=Eugene&rft.date=2011-06-01&rft.volume=39&rft.issue=4&rft.spage=653&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311406931 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Number of references - 44 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Heart; Blood; Injuries; Ovariectomy; Troponin I; Immunoassays; biomarkers; Menopause; Calcium-binding protein; Sex DO - http://dx.doi.org/10.1177/0192623311406931 ER - TY - JOUR T1 - Laboratory Assessment of Vibration Emissions from Vibrating Forks used in Simulated Beach Cleaning AN - 876229941; 15111494 AB - As part of NIOSH's response to the BP Deepwater Horizon oil spill, representatives traveled to the gulf coast to observe and assess workers involved in beach cleaning operations, to identify potential hazards and to provide guidance for protecting response workers. One beach cleaning operation involved the use of lightweight, battery-powered, motorized vibrating manure forks to remove tar balls and patties from beach sand. To investigate the vibration exposures associated with these operations, we performed a laboratory study on the vibrations produced by the forks operated during simulated beach cleaning. The objectives of this study were to characterize the vibrations associated with the use of vibrating manure forks and to estimate vibration exposure time limits based on the recommendations of ANSI S2.70-2006. JF - Canadian Acoustics AU - McDowell, T W AU - Xu, X S AU - Warren, C AU - Welcome, DE AU - Dong, R G AD - Engineering & Control Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia, USA 26505 Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 38 EP - 39 PB - Canadian Acoustical Association, PO Box 74068 Ottawa ON K1M 2H9 Canada VL - 39 IS - 2 SN - 0711-6659, 0711-6659 KW - ASFA 2: Ocean Technology Policy & Non-Living Resources; Pollution Abstracts; Oceanic Abstracts; Health & Safety Science Abstracts KW - Tar balls KW - Beaches KW - Animal wastes KW - Manure KW - Acoustics KW - Cleaning KW - Hazards KW - Coastal zone KW - Shore protection KW - Vibration KW - tar balls KW - Emissions KW - Occupational exposure KW - Oil spills KW - Q2 09405:Oil and gas KW - P 0000:AIR POLLUTION KW - O 4080:Pollution - Control and Prevention KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876229941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+Acoustics&rft.atitle=Laboratory+Assessment+of+Vibration+Emissions+from+Vibrating+Forks+used+in+Simulated+Beach+Cleaning&rft.au=McDowell%2C+T+W%3BXu%2C+X+S%3BWarren%2C+C%3BWelcome%2C+DE%3BDong%2C+R+G&rft.aulast=McDowell&rft.aufirst=T&rft.date=2011-06-01&rft.volume=39&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Canadian+Acoustics&rft.issn=07116659&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Hazards; Beaches; Coastal zone; Tar balls; Shore protection; Manure; Oil spills; Cleaning; Animal wastes; Acoustics; tar balls; Vibration; Emissions; Occupational exposure ER - TY - JOUR T1 - Association of serum alpha -tocopherol with sex steroid hormones and interactions with smoking: implications for prostate cancer risk AN - 876225804; 14895511 AB - Background: Vitamin E may protect against prostate cancer, possibly only in smokers and, we hypothesize, through altered sex steroid hormones. A controlled trial in smokers showed that sex hormone levels were inversely associated with baseline serum alpha -tocopherol and decreased in response to vitamin E supplementation. The vitamin E-hormone relation is understudied in non-smokers. Methods: Serum sex steroid hormones and alpha -tocopherol were measured for 1,457 men in NHANES III. Multivariable-adjusted geometric mean hormone concentrations by alpha -tocopherol quintile were estimated. Results: We observed lower mean testosterone, estradiol, and SHBG concentrations with increasing serum alpha -tocopherol (Q1=5.5 and Q5=4.6ng/ml, p-trend=0 .0007; Q1=37.8 and Q5=33.1pg/ml, p-trend=0.02; Q1=38.8 and Q5=30.6pg/ml, p-trend=0 .05, respectively). Interactions between serum alpha -tocopherol and exposure to cigarette smoke for total testosterone, total estradiol, and SHBG were found with the inverse relation observed only among smokers. Conclusions: Results from this nationally representative, cross-sectional study indicate an inverse association between serum alpha -tocopherol and circulating testosterone, estradiol, and SHBG, but only in men who smoked. Our findings support vitamin E selectively influencing sex hormones in smokers and afford possible mechanisms through which vitamin E may impact prostate cancer risk. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Rohrmann, Sabine AU - Menke, Andy AU - Feinleib, Manning AU - Nelson, William G AU - Platz, Elizabeth A AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA, mondulam@mail.nih.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 827 EP - 836 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 22 IS - 6 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Cigarettes KW - Clinical trials KW - Hormones KW - Smoke KW - Steroid hormones KW - Vitamins KW - clinical trials KW - prostate cancer KW - steroid hormones KW - vitamins KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Association+of+serum+alpha+-tocopherol+with+sex+steroid+hormones+and+interactions+with+smoking%3A+implications+for+prostate+cancer+risk&rft.au=Mondul%2C+Alison+M%3BRohrmann%2C+Sabine%3BMenke%2C+Andy%3BFeinleib%2C+Manning%3BNelson%2C+William+G%3BPlatz%2C+Elizabeth+A%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-06-01&rft.volume=22&rft.issue=6&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9753-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Smoke; vitamins; Cigarettes; Vitamins; steroid hormones; Steroid hormones; clinical trials; prostate cancer; Clinical trials; Hormones; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9753-4 ER - TY - JOUR T1 - Predictive microbiology models vs. modeling microbial growth within Listeria monocytogenes risk assessment: What parameters matter and why AN - 876224059; 14879224 AB - Predictive microbiology models are essential tools to model bacterial growth in quantitative microbial risk assessments. Various predictive microbiology models and sets of parameters are available: it is of interest to understand the consequences of the choice of the growth model on the risk assessment outputs. Thus, an exercise was conducted to explore the impact of the use of several published models to predict Listeria monocytogenes growth during food storage in a product that permits growth. Results underline a gap between the most studied factors in predictive microbiology modeling (lag, growth rate) and the most influential parameters on the estimated risk of listeriosis in this scenario (maximum population density, bacterial competition). The mathematical properties of an exponential dosearesponse model for Listeria accounts for the fact that the mean number of bacteria per serving and, as a consequence, the highest achievable concentrations in the product under study, has a strong influence on the estimated expected number of listeriosis cases in this context. JF - Food Microbiology AU - Pouillot, Regis AU - Lubran, Meryl B AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 720 EP - 726 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 4 SN - 0740-0020, 0740-0020 KW - Risk Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Quantitative risk assessment KW - Listeria monocytogenes KW - Predictive microbiology KW - Risk assessment KW - Growth rate KW - Mathematical models KW - Listeriosis KW - Population density KW - Microbial contamination KW - Physical training KW - Models KW - Growth KW - Microbiology KW - food storage KW - Competition KW - competition KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876224059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Predictive+microbiology+models+vs.+modeling+microbial+growth+within+Listeria+monocytogenes+risk+assessment%3A+What+parameters+matter+and+why&rft.au=Pouillot%2C+Regis%3BLubran%2C+Meryl+B&rft.aulast=Pouillot&rft.aufirst=Regis&rft.date=2011-06-01&rft.volume=28&rft.issue=4&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2010.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Growth rate; Risk assessment; Mathematical models; Listeriosis; Population density; Competition; Models; Physical training; Growth; food storage; Microbiology; Microbial contamination; competition; Listeria monocytogenes DO - http://dx.doi.org/10.1016/j.fm.2010.06.002 ER - TY - JOUR T1 - Head-repositioning does not reduce the reproducibility of fMRI activation in a block-design motor task AN - 874190248; 14975094 AB - It is hypothesized that, based upon partial volume effects and spatial non-uniformities of the scanning environment, repositioning a subject's head inside the head coil between separate functional MRI scans will reduce the reproducibility of fMRI activation compared to a series of functional runs where the subject's head remains in the same position. Nine subjects underwent fMRI scanning where they performed a sequential, oppositional finger-tapping task. The first five runs were conducted with the subject's head remaining stable inside the head coil. Following this, four more runs were collected after the subject removed and replaced his/her head inside the head coil before each run. The coefficient of variation was calculated for four metrics: the distance from the anterior commisure to the center of mass of sensorimotor activation, maximum t-statistic, activation volume, and average percent signal change. These values were compared for five head-stabilization runs and five head-repositioning runs. Voxelwise intraclass correlation coefficients were also calculated to assess the spatial distribution of sources of variance. Interestingly, head repositioning was not seen to significantly affect the reproducibility of fMRI activation (p < 0.05). In addition, the threshold level affected the reproducibility of activation volume and percent signal change. JF - NeuroImage AU - Soltysik, David A AU - Thomasson, David AU - Rajan, Sunder AU - Gonzalez-Castillo, Javier AU - DiCamillo, Paul AU - Biassou, Nadia AD - Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA, david.soltysik@fda.hhs.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 1329 EP - 1337 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 56 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - fMRI KW - Reproducibility KW - Test-retest KW - Finger-tapping KW - sensorimotor system KW - Neuroimaging KW - Head KW - Scanning KW - Spatial distribution KW - Functional magnetic resonance imaging KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874190248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Head-repositioning+does+not+reduce+the+reproducibility+of+fMRI+activation+in+a+block-design+motor+task&rft.au=Soltysik%2C+David+A%3BThomasson%2C+David%3BRajan%2C+Sunder%3BGonzalez-Castillo%2C+Javier%3BDiCamillo%2C+Paul%3BBiassou%2C+Nadia&rft.aulast=Soltysik&rft.aufirst=David&rft.date=2011-06-01&rft.volume=56&rft.issue=3&rft.spage=1329&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2011.03.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - sensorimotor system; Neuroimaging; Spatial distribution; Scanning; Head; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2011.03.023 ER - TY - JOUR T1 - Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. AN - 869793252; 21245015 AB - Mechanisms whereby gene-environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson's disease (PD)-the second most common neurodegenerative disease-remain elusive. We created a two-hit [neuroinflammation and mutant α-synuclein (α-syn) overexpression] animal model to investigate mechanisms through which mutant α-syn and inflammation work in concert to mediate chronic PD neurodegeneration. We used an intraperitoneal injection of the inflammogen lipopolysaccharide (LPS; 3 × 106 EU/kg) to initiate systemic and brain inflammation in wild-type (WT) mice and transgenic (Tg) mice overexpressing human A53T mutant α-syn. We then evaluated nigral dopaminergic neurodegeneration, α-syn pathology, and neuroinflammation. After LPS injection, both WT and Tg mice initially displayed indistinguishable acute neuroinflammation; however, only Tg mice developed persistent neuroinflammation, chronic progressive degeneration of the nigrostriatal dopamine pathway, accumulation of aggregated, nitrated α-syn, and formation of Lewy body-like inclusions in nigral neurons. Further mechanistic studies indicated that 4-week infusion of two inhibitors of inducible nitric oxide synthase and NADPH oxidase, major free radical-generating enzymes in activated microglia, blocked nigral α-syn pathology and neurodegeneration in LPS-injected Tg mice. Microglia-derived oxidative stress bridged neuroinflammation and α-syn pathogenic alteration in mediating chronic PD progression. Our two-hit animal model involving both a genetic lesion and an environmental trigger reproduced key features of PD and demonstrated synergistic effects of genetic predisposition and environmental exposures in the development of PD. The chronic progressive nature of dopaminergic neurodegeneration, which is absent in most existing PD models, makes this new model invaluable for the study of mechanisms of PD progression. JF - Environmental health perspectives AU - Gao, Hui-Ming AU - Zhang, Feng AU - Zhou, Hui AU - Kam, Wayneho AU - Wilson, Belinda AU - Hong, Jau-Shyong AD - Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. gao2@niehs.nih.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 807 EP - 814 VL - 119 IS - 6 KW - Amidines KW - 0 KW - Benzylamines KW - Lipopolysaccharides KW - N-(3-(aminomethyl)benzyl)acetamidine KW - Onium Compounds KW - alpha-Synuclein KW - diphenyleneiodonium KW - 6HJ411TU98 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Injections, Intraperitoneal KW - Benzylamines -- pharmacology KW - Onium Compounds -- pharmacology KW - Animals KW - Amidines -- pharmacology KW - Lipopolysaccharides -- immunology KW - Lipopolysaccharides -- pharmacology KW - Oxidative Stress KW - Disease Models, Animal KW - Mice KW - Animals, Genetically Modified KW - Lewy Bodies -- pathology KW - Neurodegenerative Diseases -- chemically induced KW - alpha-Synuclein -- metabolism KW - Nerve Degeneration -- immunology KW - NADPH Oxidase -- antagonists & inhibitors KW - Neurodegenerative Diseases -- immunology KW - Nerve Degeneration -- chemically induced KW - Neurodegenerative Diseases -- pathology KW - Substantia Nigra -- immunology KW - alpha-Synuclein -- genetics KW - Parkinson Disease -- genetics KW - Parkinson Disease -- pathology KW - Neurodegenerative Diseases -- genetics KW - Parkinson Disease -- immunology KW - Substantia Nigra -- pathology KW - Nitric Oxide Synthase Type II -- antagonists & inhibitors KW - Nerve Degeneration -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869793252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Neuroinflammation+and+%CE%B1-synuclein+dysfunction+potentiate+each+other%2C+driving+chronic+progression+of+neurodegeneration+in+a+mouse+model+of+Parkinson%27s+disease.&rft.au=Gao%2C+Hui-Ming%3BZhang%2C+Feng%3BZhou%2C+Hui%3BKam%2C+Wayneho%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong&rft.aulast=Gao&rft.aufirst=Hui-Ming&rft.date=2011-06-01&rft.volume=119&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1003013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-06-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 May 16;34(4):521-33 [12062037] J Neurosci. 2000 Aug 15;20(16):6309-16 [10934283] Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73 [12084935] Adv Neurol. 2003;91:133-42 [12442672] Neurosci Lett. 2003 May 1;341(2):87-90 [12686372] J Neurosci. 2003 Apr 15;23(8):3095-9 [12716914] Proc Natl Acad Sci U S A. 2003 May 13;100(10):6145-50 [12721370] Trends Pharmacol Sci. 2003 Aug;24(8):395-401 [12915048] Science. 2003 Oct 31;302(5646):841 [14593171] FASEB J. 2004 Mar;18(3):589-91 [14734632] Lancet. 2004 Sep 25-Oct 1;364(9440):1167-9 [15451224] Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71 [15451225] Ann Neurol. 2004 Oct;56(4):591-5 [15455394] Neurology. 1988 Aug;38(8):1217-9 [3399070] Neurology. 1988 Aug;38(8):1285-91 [3399080] Science. 1997 Jun 27;276(5321):2045-7 [9197268] Nature. 1997 Aug 28;388(6645):839-40 [9278044] Nat Genet. 1998 Feb;18(2):106-8 [9462735] Ann Neurol. 1998 Sep;44(3 Suppl 1):S72-84 [9749577] FASEB J. 2005 Apr;19(6):533-42 [15791003] Nat Rev Genet. 2006 Apr;7(4):306-18 [16543934] Neurobiol Aging. 2006 Jun;27(6):848-56 [16006012] Exp Neurol. 2006 Jun;199(2):499-512 [16504177] Science. 2006 Jul 21;313(5785):324-8 [16794039] Neurobiol Dis. 2007 Jan;25(1):134-49 [17055279] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Am J Pathol. 2007 Feb;170(2):658-66 [17255333] Glia. 2007 Apr 1;55(5):453-62 [17203472] Arch Neurol. 2007 Jun;64(6):836-40 [17562931] Nat Med. 2008 May;14(5):507-9 [18391961] Nat Med. 2008 May;14(5):504-6 [18391962] Nat Med. 2008 May;14(5):501-3 [18391963] J Neurosci. 2008 Jul 23;28(30):7687-98 [18650345] Trends Immunol. 2008 Aug;29(8):357-65 [18599350] J Neurosci. 2008 Oct 22;28(43):10825-34 [18945890] J Neurosci. 2009 Feb 4;29(5):1480-5 [19193894] Lancet Neurol. 2009 Apr;8(4):382-97 [19296921] Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13010-5 [19651612] Ann Neurol. 2009 Oct;66(4):494-504 [19847896] Neuron. 2010 Jun 10;66(5):646-61 [20547124] Nat Genet. 2010 Sep;42(9):781-5 [20711177] Nat Med. 1999 Dec;5(12):1403-9 [10581083] Science. 2000 Feb 18;287(5456):1265-9 [10678833] J Neurochem. 2002 Jun;81(6):1285-97 [12068076] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1003013 ER - TY - JOUR T1 - Assessing motivation in children using a progressive ratio task. AN - 868999563; 21507343 AB - The association of age and sex on the performance of a progressive ratio task was studied in 847 children, ages 4-14 years. Variations of this task have been used extensively with animals and to a lesser extent with humans to study factors that affect aspects of motivation. The participants in this study were required to press a response lever for nickel reinforcers during a 10 min period. One response was required to earn the first nickel and each subsequent nickel required an additional 10 more responses. Older children had a significantly higher breakpoint than younger children. This appeared to be mostly the result of older children having significantly shorter inter-response times than younger children. In addition, boys had significantly higher breakpoints than girls, especially at older ages. The results of this study illustrate that both age and sex influence the performance of this task and thus suggest that age and sex influence aspects of motivation in children. Further, characterization of performance of this task by humans facilitates comparisons with animal models and, thus, enhances its translational utility. Published by Elsevier B.V. JF - Behavioural processes AU - Chelonis, John J AU - Gravelin, Claire R AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, United States. John.chelonis@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 203 EP - 209 VL - 87 IS - 2 KW - Index Medicus KW - Analysis of Variance KW - Age Factors KW - Sex Factors KW - Humans KW - Child KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Child, Preschool KW - Motivation KW - Reinforcement (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868999563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+processes&rft.atitle=Assessing+motivation+in+children+using+a+progressive+ratio+task.&rft.au=Chelonis%2C+John+J%3BGravelin%2C+Claire+R%3BPaule%2C+Merle+G&rft.aulast=Chelonis&rft.aufirst=John&rft.date=2011-06-01&rft.volume=87&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Behavioural+processes&rft.issn=1872-8308&rft_id=info:doi/10.1016%2Fj.beproc.2011.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-28 N1 - Date created - 2011-05-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.beproc.2011.03.008 ER - TY - JOUR T1 - Management of HIV infection in treatment-naive patients: a review of the most current recommendations. AN - 868024465; 21593227 AB - The most current guidelines issued by the Department of Health and Human Services (DHHS) on the management of human immunodeficiency virus (HIV) infection in treatment-naive patients are reviewed. Treatment guidelines are updated frequently because of the emergence of data demonstrating the risks and benefits of antiretroviral therapy. The DHHS guidelines strongly recommend initiating therapy in patients with certain conditions regardless of CD4 cell count and in patients with CD4 cell counts of 500 cells/mm(3) is controversial. Although cumulative observational data and biological evidence support treatment at higher CD4 cell counts, randomized controlled trial data to support this are not available, and the risk of antiretroviral toxicities, resistance, non-adherence, and cost should be considered in individual patients. The preferred regimens have been consolidated to four options, including a dual-nucleoside reverse transcriptase inhibitor backbone (tenofovir plus emtricitabine) with a nonnucleoside reverse transcriptase inhibitor (efavirenz), a ritonavir-boosted protease inhibitor (atazanavir plus ritonavir or darunavir plus ritonavir), or an integrase strand-transfer inhibitor (raltegravir). Regimens are classified as alternative or acceptable when they have potential safety or efficacy concerns, have higher pill burdens, or require more-frequent administration compared with preferred regimens. The DHHS 2011 guidelines advocate earlier antiretroviral therapy initiation than recommended in recent years, and preferred regimens have been refined to maximize efficacy, safety, and quality of life for treatment-naive HIV-infected patients. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Boyd, Sarita D AD - Office of Safety and Epidemiology, Food and Drug Administration, Silver Spring, MD. sarita.boyd@fda.hhs.gov Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 991 EP - 1001 VL - 68 IS - 11 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - United States KW - Drug Therapy, Combination KW - Humans KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - United States Dept. of Health and Human Services KW - Quality of Life KW - CD4 Lymphocyte Count KW - Time Factors KW - Anti-HIV Agents -- therapeutic use KW - Practice Guidelines as Topic KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868024465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Management+of+HIV+infection+in+treatment-naive+patients%3A+a+review+of+the+most+current+recommendations.&rft.au=Boyd%2C+Sarita+D&rft.aulast=Boyd&rft.aufirst=Sarita&rft.date=2011-06-01&rft.volume=68&rft.issue=11&rft.spage=991&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=1535-2900&rft_id=info:doi/10.2146%2Fajhp100156 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-05-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 2008 Aug 23;372(9639):646-55 [18722869] AIDS. 2008 Jul 31;22(12):1522-3 [18614879] AIDS. 2008 Oct 1;22(15):1979-91 [18784461] AIDS. 2008 Oct 18;22(16):2143-53 [18832878] J Acquir Immune Defic Syndr. 2008 Dec 15;49(5):499-506 [18989230] Int J STD AIDS. 2009 Apr;20(4):276-7 [19304978] J Acquir Immune Defic Syndr. 2009 Apr 1;50(4):367-74 [19214123] Lancet. 2009 Apr 18;373(9672):1352-63 [19361855] J Acquir Immune Defic Syndr. 2009 May 1;51(1):20-8 [19282778] N Engl J Med. 2009 Apr 30;360(18):1815-26 [19339714] J Viral Hepat. 2009 Jul;16(7):471-8 [19457140] AIDS. 2009 Jul 31;23(12):1547-56 [19542866] AIDS. 2009 Aug 24;23(13):1679-88 [19487905] HIV Med. 2009 Sep;10(8):482-7 [19459988] Lancet. 2009 Sep 5;374(9692):796-806 [19647866] Clin Infect Dis. 2009 Nov 15;49(10):1591-601 [19842973] N Engl J Med. 2009 Dec 3;361(23):2230-40 [19952143] Lancet Oncol. 2009 Dec;10(12):1152-9 [19818686] AIDS. 2010 Jan 28;24(3):F1-9 [20009917] J Infect Dis. 2010 Mar 15;201(6):803-13 [20151839] Clin Infect Dis. 2010 May 15;50(10):1387-96 [20380565] AIDS. 2008 Jul 31;22(12):1389-97 [18614861] N Engl J Med. 2008 May 15;358(20):2095-106 [18480202] J Infect Dis. 2008 Apr 15;197(8):1133-44 [18476292] N Engl J Med. 2000 Mar 30;342(13):921-9 [10738050] J Acquir Immune Defic Syndr. 2002 Mar 1;29(3):275-83 [11873077] N Engl J Med. 2002 Jun 27;346(26):2039-46 [12087139] AIDS. 2002 Dec 6;16(18):2455-9 [12461420] Lancet. 2002 Dec 14;360(9349):1921-6 [12493258] Ann Intern Med. 2003 Apr 15;138(8):620-6 [12693883] Nat Med. 2003 Jun;9(6):727-8 [12754504] Lancet. 2004 Apr 17;363(9417):1253-63 [15094269] JAMA. 2004 Jul 14;292(2):191-201 [15249568] MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19 [1361652] Nature. 1997 May 8;387(6629):188-91 [9144290] J Infect Dis. 2005 Feb 1;191(3):339-47 [15633092] J Am Soc Nephrol. 2005 Aug;16(8):2412-20 [15987747] J Clin Invest. 2005 Nov;115(11):3250-5 [16276421] J Acquir Immune Defic Syndr. 2006 Mar;41(3):385-92 [16540942] MMWR Morb Mortal Wkly Rep. 2006 Jun 2;55(21):592-7 [16741495] Lancet. 2006 Aug 5;368(9534):476-82 [16890834] Nephrol Dial Transplant. 2006 Oct;21(10):2809-13 [16864598] N Engl J Med. 2006 Nov 30;355(22):2283-96 [17135583] J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):179-87 [17075385] Ann Intern Med. 2007 Apr 17;146(8):564-73 [17438315] AIDS. 2007 May 31;21(9):1185-97 [17502729] AIDS. 2007 May 31;21(9):1215-8 [17502736] J Acquir Immune Defic Syndr. 2008 Jan 1;47(1):74-8 [17971715] HIV Med. 2008 Jan;9(1):14-8 [18199168] AIDS. 2008 Feb 19;22(4):481-7 [18301060] Ann Neurol. 2008 Feb;63(2):213-21 [17894380] Lancet. 2008 Apr 26;371(9622):1417-26 [18387667] AIDS. 2008 Sep 12;22(14):F17-24 [18753925] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2146/ajhp100156 ER - TY - JOUR T1 - Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: implications for human efficacy and toxicity. AN - 867320513; 21466783 AB - Glucosamine is used for alleviating pain in osteoarthritis. Clinical trials have reported that glucosamine has equivocal efficacy. Glucosamine is also used in cell cultures to stimulate hexosamine flux and protein O-glycosylation, but at many-fold greater concentrations than those in human plasma following oral dosing. Lean Zucker rats were dosed orally for 6 weeks with glucosamine hydrochloride at doses (0-600 mg/kg/day) that produced peak serum concentrations of <1-35 μM, spanning the human exposure range. Relative expression of both TGFβ1 and CTGF mRNA were significantly increased up to 2.3-fold in liver, kidney and articular cartilage when evaluated 4h after final dose. Apparent threshold serum glucosamine (C(max)) concentration required to increase TGFβ1 expression in cartilage was 10-20 μM. These increases were associated with significant increases in UDP-N-acetylglucosamine concentrations suggesting increased hexosamine flux. Both TGFβ1 and CTGF are mediators of chondrocyte proliferation and cartilage repair. Study demonstrates that oral glucosamine doses that produce clinically relevant serum glucosamine concentrations can induce tissue TGFβ1 and CTGF expression in vivo and provides a mechanistic rationale for reported beneficial effects of glucosamine therapy. Induction of renal TGFβ1 and CTGF mRNA suggests that potential sclerotic side-effects may occur following consumption of potent glucosamine preparations. Published by Elsevier Inc. JF - Archives of biochemistry and biophysics AU - Ali, Akhtar A AU - Lewis, Sherry M AU - Badgley, Heidi L AU - Allaben, William T AU - Leakey, Julian E A AD - Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/06/01/ PY - 2011 DA - 2011 Jun 01 SP - 11 EP - 18 VL - 510 IS - 1 KW - RNA, Messenger KW - 0 KW - Transforming Growth Factor beta1 KW - Connective Tissue Growth Factor KW - 139568-91-5 KW - Glucosamine KW - N08U5BOQ1K KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Humans KW - Up-Regulation -- drug effects KW - Osteoarthritis -- drug therapy KW - RNA, Messenger -- genetics KW - Rats, Zucker KW - Male KW - Cartilage, Articular -- metabolism KW - Kidney -- metabolism KW - Glucosamine -- blood KW - Cartilage, Articular -- drug effects KW - Glucosamine -- administration & dosage KW - Kidney -- drug effects KW - Transforming Growth Factor beta1 -- genetics KW - Glucosamine -- urine KW - Glucosamine -- pharmacology KW - Connective Tissue Growth Factor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867320513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Oral+glucosamine+increases+expression+of+transforming+growth+factor+%CE%B21+%28TGF%CE%B21%29+and+connective+tissue+growth+factor+%28CTGF%29+mRNA+in+rat+cartilage+and+kidney%3A+implications+for+human+efficacy+and+toxicity.&rft.au=Ali%2C+Akhtar+A%3BLewis%2C+Sherry+M%3BBadgley%2C+Heidi+L%3BAllaben%2C+William+T%3BLeakey%2C+Julian+E+A&rft.aulast=Ali&rft.aufirst=Akhtar&rft.date=2011-06-01&rft.volume=510&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=1096-0384&rft_id=info:doi/10.1016%2Fj.abb.2011.03.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-25 N1 - Date created - 2011-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.abb.2011.03.014 ER - TY - JOUR T1 - Comparative profile of commercially available urinary biomarkers in preclinical drug-induced kidney injury and recovery in rats. AN - 866534223; 21150870 AB - We designed a study to provide reversibility and comparative injury data for several candidate urinary biomarkers of kidney injury in the United States Food and Drug Administration biomarker qualification process. The nephrotoxin gentamicin was given to rats once on each of three days and the animals were killed during dosing or over the following 42 days. Between days one and three, all biomarkers except albumin were elevated, peaked at day 7, and returned to control levels by day 10 (μ- and α-glutathione S-transferases, and renal papillary antigen-1) or day 15 (kidney injury molecule-1, lipocalin-2, osteopontin, and clusterin). All biomarkers performed better during injury than during recovery except osteopontin, which performed equally well in both time periods. During the evolution of injury, kidney injury molecule-1, renal papillary antigen-1, and clusterin best mirrored the histopathologic lesions. During injury resolution, kidney injury molecule-1, osteopontin, and blood urea nitrogen best reflected recovery. Based on histopathology, necrosis, or apoptosis scoring, kidney injury molecule-1 was the best biomarker of overall renal injury. Evaluation by regeneration score showed that renal papillary antigen-1 best reflected tubular and/or collecting duct regeneration, especially during recovery. Thus, these biomarkers performed with different effectiveness when evaluated by individual pathological processes such as necrosis, apoptosis, and regeneration. JF - Kidney international AU - Rouse, Rodney L AU - Zhang, Jun AU - Stewart, Sharron R AU - Rosenzweig, Barry A AU - Espandiari, Parvaneh AU - Sadrieh, Nakissa K AD - Division of Applied Pharmacology Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Rodney.rouse@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 1186 EP - 1197 VL - 79 IS - 11 KW - Biomarkers KW - 0 KW - Cell Adhesion Molecules KW - Clu protein, rat KW - Clusterin KW - Gentamicins KW - Havcr1protein, rat KW - Lipocalins KW - Reagent Kits, Diagnostic KW - Spp1 protein, rat KW - Osteopontin KW - 106441-73-0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Animals KW - Apoptosis KW - ROC Curve KW - Osteopontin -- urine KW - Predictive Value of Tests KW - Glutathione Transferase -- urine KW - Cell Adhesion Molecules -- urine KW - Rats KW - Rats, Sprague-Dawley KW - Necrosis KW - Regeneration KW - Lipocalins -- urine KW - Time Factors KW - Clusterin -- urine KW - Immunohistochemistry KW - Male KW - Proteomics -- methods KW - Kidney Tubules, Proximal -- metabolism KW - Acute Kidney Injury -- pathology KW - Acute Kidney Injury -- chemically induced KW - Acute Kidney Injury -- physiopathology KW - Biomarkers -- urine KW - Kidney Tubules, Proximal -- pathology KW - Kidney Tubules, Proximal -- physiopathology KW - Biomarkers -- blood KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866534223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Comparative+profile+of+commercially+available+urinary+biomarkers+in+preclinical+drug-induced+kidney+injury+and+recovery+in+rats.&rft.au=Rouse%2C+Rodney+L%3BZhang%2C+Jun%3BStewart%2C+Sharron+R%3BRosenzweig%2C+Barry+A%3BEspandiari%2C+Parvaneh%3BSadrieh%2C+Nakissa+K&rft.aulast=Rouse&rft.aufirst=Rodney&rft.date=2011-06-01&rft.volume=79&rft.issue=11&rft.spage=1186&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=1523-1755&rft_id=info:doi/10.1038%2Fki.2010.463 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-13 N1 - Date created - 2011-05-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Kidney Int. 2011 Jun;79(11):1159-61 [21566636] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/ki.2010.463 ER - TY - JOUR T1 - The state of nano-sized titanium dioxide (TiO2) may affect sunscreen performance. AN - 865189354; 21265867 AB - In the past several years, there has been a trend in the sunscreen/cosmetics industry to replace micron-sized titanium dioxide (TiO(2)) particles with nanoscale materials. The increased use of nanoscale TiO(2) has resulted in questions about these and other nanoproducts. This study examines the effects of using nanoscale TiO(2) on ultraviolet (UV) attenuation in simple to complex sunscreen formulations. UV light attenuation, product stability, and potential damage to the skin barrier were examined with both nanoscale and microscale TiO(2) particles. Results indicate that none of the formulations decreased the barrier function of the skin and the best UV attenuation occurs when the TiO(2) particles are stabilized with a coating and evenly distributed such as with non-agglomerated coated nanoscale materials. This indicates that nanoscale TiO(2) may have better efficacy while lacking toxicity. © 2011 The Authors. ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie. JF - International journal of cosmetic science AU - Tyner, K M AU - Wokovich, A M AU - Godar, D E AU - Doub, W H AU - Sadrieh, N AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. nakissa.sadrieh@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 234 EP - 244 VL - 33 IS - 3 KW - Sunscreening Agents KW - 0 KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Microscopy, Electron, Transmission KW - Drug Stability KW - Ultraviolet Rays KW - X-Ray Diffraction KW - Skin, Artificial KW - Humans KW - Spectrophotometry, Ultraviolet KW - Structure-Activity Relationship KW - Microscopy, Electron, Scanning KW - Titanium -- chemistry KW - Sunscreening Agents -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/865189354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cosmetic+science&rft.atitle=The+state+of+nano-sized+titanium+dioxide+%28TiO2%29+may+affect+sunscreen+performance.&rft.au=Tyner%2C+K+M%3BWokovich%2C+A+M%3BGodar%2C+D+E%3BDoub%2C+W+H%3BSadrieh%2C+N&rft.aulast=Tyner&rft.aufirst=K&rft.date=2011-06-01&rft.volume=33&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cosmetic+science&rft.issn=1468-2494&rft_id=info:doi/10.1111%2Fj.1468-2494.2010.00622.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-25 N1 - Date created - 2011-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1468-2494.2010.00622.x ER - TY - JOUR T1 - Translational biomarkers: from preclinical to clinical a report of 2009 AAPS/ACCP Biomarker Workshop. AN - 864784797; 21448748 AB - There have been some successes in qualifying biomarkers and applying them to drug development and clinical treatment of various diseases. A recent success is illustrated by a collaborative effort among the US Food and Drug Administration, the European Medicines Agency, and the pharmaceutical industry to provide a set of seven preclinical kidney toxicity biomarkers for drug development. Other successes include, but are not limited to, clinical biomarkers for cancer treatment and clinical management of heart transplant patients. The value of fully qualified surrogate endpoints in facilitating successful drug development is undisputed, especially for diseases in which the traditional clinical outcome can only be assessed in large, multi-year trials. Emerging biomarkers, including chemical genomic or imaging biomarkers, and measurement of circulating tumor cells hold great promise for early diagnosis of disease and as prognostic tests for managing treatment of chronic diseases such as osteoarthritis, Alzheimer disease, cardiovascular disease, and cancer. To advance the success of treating and managing these diseases, efforts are needed to establish the temporal relationship between changes in inflammatory or imaging biomarkers with the progression of the chronic disease, and in the case of cancer, between the extent of circulating cancer cells and tumor progression or remission. JF - The AAPS journal AU - Bai, Jane P F AU - Bell, Robert AU - Buckman, ShaAvhree AU - Burckart, Gilbert J AU - Eichler, Hans-Georg AU - Fang, Kenneth C AU - Goodsaid, Federico M AU - Jusko, William J AU - Lesko, Lawrence L AU - Meibohm, Bernd AU - Patterson, Scott D AU - Puig, Oscar AU - Smerage, Jeffrey B AU - Snider, Barbara J AU - Wagner, John A AU - Wang, Jingsong AU - Walton, Marc K AU - Weiner, Russell AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. jbai.bai@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 274 EP - 283 VL - 13 IS - 2 KW - Biomarkers KW - 0 KW - Index Medicus KW - Animals KW - International Cooperation KW - Humans KW - Drug Evaluation, Preclinical -- methods KW - Clinical Trials as Topic -- methods KW - Biomarkers -- metabolism KW - Drug Design KW - Drug Industry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864784797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Translational+biomarkers%3A+from+preclinical+to+clinical+a+report+of+2009+AAPS%2FACCP+Biomarker+Workshop.&rft.au=Bai%2C+Jane+P+F%3BBell%2C+Robert%3BBuckman%2C+ShaAvhree%3BBurckart%2C+Gilbert+J%3BEichler%2C+Hans-Georg%3BFang%2C+Kenneth+C%3BGoodsaid%2C+Federico+M%3BJusko%2C+William+J%3BLesko%2C+Lawrence+L%3BMeibohm%2C+Bernd%3BPatterson%2C+Scott+D%3BPuig%2C+Oscar%3BSmerage%2C+Jeffrey+B%3BSnider%2C+Barbara+J%3BWagner%2C+John+A%3BWang%2C+Jingsong%3BWalton%2C+Marc+K%3BWeiner%2C+Russell&rft.aulast=Bai&rft.aufirst=Jane+P&rft.date=2011-06-01&rft.volume=13&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-011-9265-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-26 N1 - Date created - 2011-05-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet. 2001 Feb 24;357(9256):577-81 [11558482] Pharmacogenomics. 2010 Feb;11(2):227-36 [20136361] Mol Neurobiol. 2001 Aug-Dec;24(1-3):87-97 [11831556] Lancet Neurol. 2003 Oct;2(10):605-13 [14505582] N Engl J Med. 1999 Jan 7;340(1):14-22 [9878640] NMR Biomed. 2006 Oct;19(6):669-80 [16986116] Clin Pharmacol Ther. 2007 Jan;81(1):104-7 [17186007] Arch Neurol. 2007 Mar;64(3):343-9 [17210801] J Heart Lung Transplant. 2007 Dec;26(12):1270-80 [18096478] Annu Rev Pharmacol Toxicol. 2008;48:631-51 [17937595] Cancer Invest. 2008 Mar;26(2):109-14 [18259939] J Clin Oncol. 2008 Apr 1;26(10):1626-34 [18316791] N Engl J Med. 2008 Apr 3;358(14):1431-43 [18376000] Mol Pharm. 2008 Mar-Apr;5(2):328-39 [18271548] Clin Cancer Res. 2008 Jun 15;14(12):3646-50 [18559576] J Pharmacol Exp Ther. 2008 Aug;326(2):546-54 [18448864] J Clin Neurosci. 2008 Oct;15(10):1137-41 [18703337] Neurology. 2009 Apr 28;72(17):1504-11 [19398705] Nat Rev Clin Oncol. 2009 Jun;6(6):306-7 [19483733] BMC Cardiovasc Disord. 2009;9:27 [19549340] JAMA. 2009 Jul 22;302(4):385-93 [19622817] Clin Pharmacol Ther. 2009 Dec;86(6):619-25 [19553931] Erratum In: AAPS J. 2011 Sep;13(3):493 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1208/s12248-011-9265-x ER - TY - JOUR T1 - Pharmacogenetics, pharmacogenomics, and individualized medicine. AN - 863903058; 21436344 AB - Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics and human genomics in recent years has dramatically accelerated the discovery of new genetic variations that potentially underlie variability in drug response, giving birth to pharmacogenomics. In addition to the rapid accumulation of knowledge on genome-disease and genome-drug interactions, there arises the hope of individualized medicine. Here we review recent progress in the understanding of genetic contributions to major individual variability in drug therapy with focus on genetic variations of drug target, drug metabolism, drug transport, disease susceptibility, and drug safety. Challenges to future pharmacogenomics and its translation into individualized medicine, drug development, and regulation are discussed. For example, knowledge on genetic determinants of disease pathogenesis and drug action, especially those of complex disease and drug response, is not always available. Relating the many gene variations from genomic sequencing to clinical phenotypes may not be straightforward. It is often very challenging to conduct large scale, prospective studies to establish causal associations between genetic variations and drug response or to evaluate the utility and cost-effectiveness of genomic medicine. Overcoming the obstacles holds promise for achieving the ultimate goal of effective and safe medication to targeted patients with appropriate genotypes. JF - Pharmacological reviews AU - Ma, Qiang AU - Lu, Anthony Y H AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505, USA. qam1@cdc.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 437 EP - 459 VL - 63 IS - 2 KW - Pharmaceutical Preparations KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Pharmaceutical Preparations -- administration & dosage KW - Animals KW - Pharmaceutical Preparations -- metabolism KW - Polymorphism, Genetic KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Cytochrome P-450 Enzyme System -- metabolism KW - Drug Design KW - Drug Delivery Systems KW - Precision Medicine -- methods KW - Pharmacogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863903058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+reviews&rft.atitle=Pharmacogenetics%2C+pharmacogenomics%2C+and+individualized+medicine.&rft.au=Ma%2C+Qiang%3BLu%2C+Anthony+Y+H&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2011-06-01&rft.volume=63&rft.issue=2&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Pharmacological+reviews&rft.issn=1521-0081&rft_id=info:doi/10.1124%2Fpr.110.003533 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-11 N1 - Date created - 2011-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/pr.110.003533 ER - TY - RPRT T1 - Understanding and Choosing Assessments and Developmental Screeners for Young Children Ages 3-5: Profiles of Selected Measures. OPRE Report #2011-23 AN - 1826528357; ED566870 AB - The 2007 reauthorization of Head Start requires Head Start programs to use child assessments and developmental screeners that are developmentally, linguistically, and culturally appropriate, as well as valid and reliable in the language in which they are used. This can be a challenge, since very few child assessment tools are developed or tested with linguistically and culturally diverse samples or with samples of children with disabilities. This compendium has been created to address this need and to promote the use of reliable and valid assessment data, wherever possible, in Head Start and other early childhood programs. This document has three purposes. First, the compendium aims to help Head Start managers and other early childhood education administrators review information regarding the reliability and validity of commonly used assessment and developmental screening tools in order to help them better select appropriate tools for the populations they serve. Second, the compendium aims more generally to increase awareness about reliability and validity and how to evaluate whether an instrument is reliable and valid for the population and purpose for which it will be used. Finally, the compendium aims to highlight areas in which the early childhood field is lacking information on reliability and validity of early childhood assessments and developmental screeners. While originally developed in response to Head Start's reauthorization, the compendium is designed to be useful to managers and staff who work in different types of early childhood education programs and who are responsible for selecting and evaluating assessment or screening instruments. This compendium is meant to aid by doing the following: (1) Summarize information from the assessment and developmental screening instruments most commonly used by Head Start programs for 3-, 4-, and 5-year-olds; (2) Share reliability and validity data as it relates to key populations of children, including dual language learners and children with disabilities, as well as the children served in American Indian/Alaska Native and Migrant and Seasonal Head Start programs; and (3) Translate information on reliability and validity in a way that is quicker and easier for Head Start managers and others to understand and use. The compendium also has a broader goal: to increase understanding of reliability and validity more generally among Head Start and early childhood managers. The following are appended: (1) Glossary of Terms; and (2) Psychometric Documentation and Rationale. AU - Halle, Tamara AU - Zaslow, Martha AU - Wessel, Julia AU - Moodie, Shannon AU - Darling-Churchill, Kristen Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 195 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Test Validity KW - Test Selection KW - Psychometrics KW - Bilingualism KW - Screening Tests KW - Evaluation Methods KW - Test Reliability KW - Federal Legislation KW - English Language Learners KW - Disabilities KW - Child Development KW - Disadvantaged Youth KW - Guides KW - Migrant Children KW - American Indian Students KW - Preschool Children KW - Alaska Natives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826528357?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Evolution patterns of raltegravir-resistant mutations after integrase inhibitor interruption AN - 1545938109 AB - Clin Microbiol Infect 2011; 17: 928-934 The objective of this study was to address the evolution of human immunodeficiency virus type 1 (HIV-1) mutations resistant to the integrase inhibitor raltegravir after drug interruption. Thirteen HIV-1 infected patients undergoing virological failure due to the selection of raltegravir-resistant variants, who had interrupted raltegravir treatment, were enrolled. For all patients, the virological failure was associated with the selection of variants, with mutations conferring resistance to all of the drugs present in their regimens. Patients were prospectively monitored at baseline (raltegravir interruption) and every 4-24 weeks for clinical, virological and immunological parameters, including HIV-1 viraemia, CD4+ T-cell counts, and sequence analysis of the HIV-1 integrase sequence. Reversion to the wild-type HIV-1 integrase sequence genotype was observed between 4 and 36 weeks after raltegravir withdrawal in eight out of the 13 patients. Reversion was not observed in three patients. In two patients, reversion was partial at week 24 from raltegravir interruption. These results highlight that in eight out of 13 patients under treatment with raltegravir and experiencing a virological failure, HIV-1 variants harbouring mutations associated with raltegravir resistance become undetectable after drug interruption within a few weeks (in some cases, very rapidly). This occurs under different therapy regimens and in patients receiving 3TC mono-therapy. In the other patients, complete reversion of the integrase sequence is not observed, and either primary or secondary resistance mutations are fixed in the replication competent viral population in vivo also for long time, suggesting that other factors may influence this dynamic process. [PUBLICATION ABSTRACT] JF - Clinical Microbiology and Infection AU - Canducci, F AU - Barda, B AU - Ceresola, E AU - Spagnuolo, V AU - Sampaolo, M AU - Boeri, E AU - Nozza, S AU - Cossarin, F AU - Galli, A AU - Gianotti, N AU - Castagna, A AU - Lazzarin, A AU - Clementi, M Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 928 EP - 934 CY - Basel PB - Elsevier Limited VL - 17 IS - 6 SN - 1198743X KW - Medical Sciences KW - Human immunodeficiency virus--HIV KW - Mutation KW - Medical research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1545938109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+and+Infection&rft.atitle=Evolution+patterns+of+raltegravir-resistant+mutations+after+integrase+inhibitor+interruption&rft.au=Canducci%2C+F%3BBarda%2C+B%3BCeresola%2C+E%3BSpagnuolo%2C+V%3BSampaolo%2C+M%3BBoeri%2C+E%3BNozza%2C+S%3BCossarin%2C+F%3BGalli%2C+A%3BGianotti%2C+N%3BCastagna%2C+A%3BLazzarin%2C+A%3BClementi%2C+M&rft.aulast=Canducci&rft.aufirst=F&rft.date=2011-06-01&rft.volume=17&rft.issue=6&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+and+Infection&rft.issn=1198743X&rft_id=info:doi/10.1111%2Fj.1469-0691.2010.03375.x LA - English DB - ProQuest Central N1 - Copyright - © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases N1 - Last updated - 2016-05-14 DO - http://dx.doi.org/10.1111/j.1469-0691.2010.03375.x ER - TY - JOUR T1 - Can Marriage Reduce Risky Health Behavior for African-Americans AN - 1322718869; 201313106 AB - This paper estimates whether marriage can improve health outcomes for African-Americans through changes in risky health behaviors like smoking, drinking, and drug use. Using data from the National Longitudinal Study on Adolescent Health and propensity score matching methodology to account for the potential selection bias, the results show that marriage does lead to a reduction in risky health behaviors, specifically drinking and drug use. This question has important policy implications because if marriage has the same benefits for African-Americans as it does for the general population, social welfare programs can be re-evaluated to incorporate marriage promotion, and further support can be given to programs that decrease adverse health behaviors. Adapted from the source document. JF - Journal of Family and Economic Issues AU - Ali, Mir M AU - Ajilore, Olugbenga AD - Department of Economics, University of Toledo and Office of Regulations, Policy & Social Science, Food & Drug Administration, College Park, MD, 20740, USA mir.ali@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - June 2011 SP - 191 EP - 203 PB - Springer, Dordrecht The Netherlands VL - 32 IS - 2 SN - 1058-0476, 1058-0476 KW - Black Americans KW - Health Problems KW - Health Behavior KW - Health KW - Marriage KW - Social Programs KW - Adolescents KW - Social Welfare KW - Drug Abuse KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322718869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+and+Economic+Issues&rft.atitle=Can+Marriage+Reduce+Risky+Health+Behavior+for+African-Americans&rft.au=Ali%2C+Mir+M%3BAjilore%2C+Olugbenga&rft.aulast=Ali&rft.aufirst=Mir&rft.date=2011-06-01&rft.volume=32&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+and+Economic+Issues&rft.issn=10580476&rft_id=info:doi/10.1007%2Fs10834-010-9242-z LA - English DB - Sociological Abstracts N1 - Date revised - 2013-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JFEIEE N1 - SubjectsTermNotLitGenreText - Marriage; Health Behavior; Black Americans; Drug Abuse; Social Welfare; Social Programs; Health Problems; Adolescents; Health DO - http://dx.doi.org/10.1007/s10834-010-9242-z ER - TY - JOUR T1 - Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes Mellitus and Influenced by NF[kappa]B and JNK in Human Abdominal Subcutaneous Adipocytes AN - 1304770973 AB - Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipose tissue and correlated with obesity. However, recent studies suggest visfatin may act as a proinflammatory cytokine. Our studies sought to determine the significance of this adipocytokine and its potential role in the pathogenesis of T2DM. Firstly, we examined the effects of diabetic status on circulating visfatin levels, and several other adipocytokines, demonstrating that diabetic status increased visfatin*, TNF-α*** and IL-6*** compared with non-diabetic subjects (*p<0.05, **p<0.01, ***p<0.001, respectively). We then assessed the effects of an insulin sensitizer, rosiglitazone (RSG), in treatment naïve T2DM subjects, on circulating visfatin levels. Our findings showed that visfatin was reduced post-RSG treatment [vs. pre-treatment (*p<0.05)] accompanied by a reduction in HOMA-IR**, thus implicating a role for insulin in visfatin regulation. Further studies addressed the intracellular mechanisms by which visfatin may be regulated, and may exert pro-inflammatory effects, in human abdominal subcutaneous (Abd Sc) adipocytes. Following insulin (Ins) and RSG treatment, our in vitro findings highlighted that insulin (100 nM), alone, upregulated visfatin protein expression whereas, in combination with RSG (10 nM), it reduced visfatin*, IKKβ** and p-JNK1/2*. Furthermore, inhibition of JNK protein exacted a significant reduction in visfatin expression (**p<0.01), whilst NF-κB blockade increased visfatin (*p<0.05), thus identifying JNK as the more influential factor in visfatin regulation. Additional in vitro analysis on adipokines regulating visfatin showed that only Abd Sc adipocytes treated with recombinant human (rh)IL-6 increased visfatin protein (*p<0.05), whilst rh visfatin treatment, itself, had no influence on TNF-α, IL-6 or resistin secretion from Sc adipocytes. These data highlight visfatin's regulation by insulin and RSG, potentially acting through NF-κB and JNK mechanisms, with only rh IL-6 modestly affecting visfatin regulation. Taken together, these findings suggest that visfatin may represent a pro-inflammatory cytokine that is influenced by insulin/insulin sensitivity via the NF-κB and JNK pathways. JF - PLoS One AU - McGee, Kirsty C AU - Harte, Alison L AU - Silva, Nancy Fda AU - Al-Daghri, Nasser AU - Creely, Steven J AU - Kusminski, Christine M AU - Tripathi, Gyanendra AU - Levick, Paul L AU - Khanolkar, Manish AU - Evans, Marc AU - Chittari, Madhu V AU - Patel, Vinod AU - Kumar, Sudhesh AU - McTernan, Philip G Y1 - 2011/06// PY - 2011 DA - Jun 2011 CY - San Francisco PB - Public Library of Science VL - 6 IS - 6 KW - Sciences: Comprehensive Works KW - Metabolic disorders KW - Proteins KW - Diabetes KW - Cytokines KW - Kinases KW - Insulin KW - Rodents KW - Abdomen KW - Studies KW - Pathogenesis KW - Obesity KW - Insulin resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1304770973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Visfatin+Is+Regulated+by+Rosiglitazone+in+Type+2+Diabetes+Mellitus+and+Influenced+by+NF%5Bkappa%5DB+and+JNK+in+Human+Abdominal+Subcutaneous+Adipocytes%3A+e20287&rft.au=McGee%2C+Kirsty+C%3BHarte%2C+Alison+L%3BSilva%2C+Nancy+Fda%3BAl-Daghri%2C+Nasser%3BCreely%2C+Steven+J%3BKusminski%2C+Christine+M%3BTripathi%2C+Gyanendra%3BLevick%2C+Paul+L%3BKhanolkar%2C+Manish%3BEvans%2C+Marc%3BChittari%2C+Madhu+V%3BPatel%2C+Vinod%3BKumar%2C+Sudhesh%3BMcTernan%2C+Philip+G&rft.aulast=McGee&rft.aufirst=Kirsty&rft.date=2011-06-01&rft.volume=6&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0020287 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2011 McGee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: McGee KC, Harte AL, da Silva NF, Al-Daghri N, Creely SJ, et al. (2011) Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes Mellitus and Influenced by NF?B and JNK in Human Abdominal Subcutaneous Adipocytes. PLoS ONE 6(6): e20287. doi:10.1371/journal.pone.0020287 N1 - Last updated - 2013-02-24 DO - http://dx.doi.org/10.1371/journal.pone.0020287 ER - TY - JOUR T1 - Exposure Control Strategies in the Carbonaceous Nanomaterial Industry AN - 1020840497; 15112471 AB - Objective: Little is known about exposure control strategies currently being implemented to minimize exposures during the production or use of nanomaterials in the United States. Our goal was to estimate types and quantities of materials used and factors related to workplace exposure reductions among companies manufacturing or using engineered carbonaceous nanomaterials (ECNs). Methods: Information was collected through phone surveys on work practices and exposure control strategies from 30 participating producers and users of ECN. The participants were classified into three groups for further examination. Results: We report here the use of exposure control strategies. Observed patterns suggest that large-scale manufacturers report greater use of nanospecific exposure control strategies particularly for respiratory protection. Conclusion: Workplaces producing or using ECN generally report using engineering and administrative controls as well as personal protective equipment to control workplace employee exposure. JF - Journal of Occupational and Environmental Medicine AU - Dahm, M M AU - Yencken AU - Schubauer-Berigan, M K AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, 4676 Columbia Parkway, MS-R14, Cincinnati, OH 45226, USA, mdahm@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S68 EP - S73 VL - 53 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Nanotechnology KW - Occupational exposure KW - Protective equipment KW - USA KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020840497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Exposure+Control+Strategies+in+the+Carbonaceous+Nanomaterial+Industry&rft.au=Dahm%2C+M+M%3BYencken%3BSchubauer-Berigan%2C+M+K&rft.aulast=Dahm&rft.aufirst=M&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S68&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821b1d3b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Protective equipment; Occupational exposure; Nanotechnology; USA DO - http://dx.doi.org/10.1097/JOM.0b013e31821b1d3b ER - TY - JOUR T1 - Introduction to the JOEM Supplement Nanomaterials and Worker Health: Medical Surveillance, Exposure Registries, and Epidemiologic Research AN - 1020840432; 15112455 AB - This issue presents selected articles from the Nanomaterial Workers' Health Conference held in Keystone, Colorado, July 21 to 23, 2010. The conference addressed three critical and related topics: medical surveillance; formation of exposure registries; and the conduct of epidemiologic research. Each topic was introduced with a plenary session followed by group breakout sessions to obtain input from the approximately 120 attendees. This supplement issue of the Journal of Occupational and Environmental Medicine includes selected peer reviewed articles from the conference and summaries of the breakout sessions. JF - Journal of Occupational and Environmental Medicine AU - Schulte, P A AU - Trout, D B AU - Hodson, L L AD - Nanotechnology Research Center National Institute for Occupational Safety and Health Cincinnati, OH, USA Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S1 EP - S2 VL - 53 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Conferences KW - Occupational exposure KW - Reviews KW - nanotechnology KW - USA, Colorado KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020840432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Introduction+to+the+JOEM+Supplement+Nanomaterials+and+Worker+Health%3A+Medical+Surveillance%2C+Exposure+Registries%2C+and+Epidemiologic+Research&rft.au=Schulte%2C+P+A%3BTrout%2C+D+B%3BHodson%2C+L+L&rft.aulast=Schulte&rft.aufirst=P&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821aec09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Conferences; Reviews; Occupational exposure; nanotechnology; USA, Colorado DO - http://dx.doi.org/10.1097/JOM.0b013e31821aec09 ER - TY - JOUR T1 - Analysis of mutations in the Pig-a gene of spleen T-cells from N-ethyl-N-nitrosourea-treated fisher 344 rats AN - 1020838711; 16695287 AB - A rapid in vivo somatic cell gene mutation assay is being developed that measures mutation in the endogenous X-linked phosphatidylinositol glycan, class A gene (Pig-a). The assay detects Pig-a mutants by flow cytometric identification of cells deficient in glycosylphosphatidyl inositol (GPI) anchor synthesis. GPI-deficient, presumed Pig-a mutant cells also can be detected in a cloning assay that uses proaerolysin (ProAER) selection. Previously, we demonstrated that ProAER-resistant (ProAERr) rat spleen T-cells have mutations in the Pig-a gene. In the present study, we report on a more complete analysis of ProAERr rat spleen T-cell mutants and describe a mutation spectrum for mutants isolated from rats 4 weeks after treatment with three consecutive doses of 35.6 mg/kg N-ethyl-N-nitrosourea (ENU). We identified a total of 55 independent mutations, with the largest percentage (69%) involving basepair substitution at A:T. The overall spectrum of Pig-a gene mutations was consistent with the types of DNA adducts formed by ENU and was very similar to what has been described for in vivo ENU-induced mutation spectra in other rodent reporter genes (e.g., in the endogenous Hprt gene and transgenic shuttle vectors). These data are consistent with the rat Pig-a assay detecting test-agent-induced mutational responses. Environ. Mol. Mutagen., 2011. Published 2011 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Miura, Daishiro AU - Shaddock, Joseph G AU - Mittelstaedt, Roberta A AU - Dobrovolsky, Vasily N AU - Kimoto, Takafumi AU - Kasahara, Yoshinori AU - Heflich, Robert H AD - Teijin Pharma, Ltd, Tokyo, Japan, robert.heflich@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 419 EP - 423 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts; Water Resources Abstracts KW - Mutagens KW - phosphatidylinositol KW - X chromosome KW - shuttle vectors KW - Polysaccharides KW - Somatic cells KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Assay KW - Lymphocytes T KW - Ethyl nitrosourea KW - Glycosylphosphatidylinositol KW - Synthesis KW - Rodents KW - Base pairs KW - Testing Procedures KW - DNA adducts KW - Data processing KW - Anchors KW - Point mutation KW - Cloning KW - Spleen KW - Hypoxanthine phosphoribosyltransferase KW - DNA KW - Mutation KW - rodents KW - G 07710:Chemical Mutagenesis & Radiation KW - SW 0540:Properties of water KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020838711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Analysis+of+mutations+in+the+Pig-a+gene+of+spleen+T-cells+from+N-ethyl-N-nitrosourea-treated+fisher+344+rats&rft.au=Miura%2C+Daishiro%3BShaddock%2C+Joseph+G%3BMittelstaedt%2C+Roberta+A%3BDobrovolsky%2C+Vasily+N%3BKimoto%2C+Takafumi%3BKasahara%2C+Yoshinori%3BHeflich%2C+Robert+H&rft.aulast=Miura&rft.aufirst=Daishiro&rft.date=2011-06-01&rft.volume=52&rft.issue=5&rft.spage=419&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20654 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20654/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Mutagens; DNA adducts; Data processing; phosphatidylinositol; Point mutation; X chromosome; Cloning; Spleen; shuttle vectors; Somatic cells; Polysaccharides; Mutagenesis; Flow cytometry; Hypoxanthine phosphoribosyltransferase; Lymphocytes T; Ethyl nitrosourea; Glycosylphosphatidylinositol; Base pairs; Rats; DNA; Mutation; rodents; Mutants; Testing Procedures; Anchors; Assay; Synthesis; Rodents DO - http://dx.doi.org/10.1002/em.20654 ER - TY - JOUR T1 - Accumulation of K-Ras codon 12 mutations in the F344 rat distal colon following azoxymethane exposure AN - 1020838704; 16695286 AB - Azoxymethane (AOM) administration to F344 male rats is a widely used model of human colon carcinogenesis. The current study investigates quantitatively the accumulation of K-Ras codon 12 mutations following AOM exposure. Male, 6-week-old F344 rats were treated subcutaneously with 30 mg/kg body weight of AOM, and colon tissue was collected at 1, 8, 24, and 32 weeks after treatment. The K-Ras codon 12 GGT to GAT and GGT to GTT mutant fractions (MFs) were measured using allele-specific competitive blocker polymerase chain reaction (ACB-PCR). Between 1 and 32 weeks after AOM treatment, the K-Ras codon 12 GGT to GAT geometric mean MF in the rat colon increased significantly from 12.9 X 10-5 to 145 X 10-5, and the GGT to GTT geometric mean MF increased significantly from 5.26 X 10-5 to 180 X 10-5. K-Ras codon 12 GGT to GAT MF also increased significantly in AOM-treated rat colon tissue at 1 week compared to controls (4.44 X 10-5). The accumulation of the GGT to GAT MF long after the DNA adduct repair phase suggests that a portion of cells containing this mutation have a proliferative advantage, allowing them to accumulate as nascent tumors progress. Also, the GGT to GAT background MF increased in untreated rats, indicating that there is accumulation with age. The ACB-PCR assay generates quantitative data of cancer-related mutations and thus provides insight into pathological processes following carcinogen exposure. Environ. Mol. Mutagen., 2011. ? Published 2011 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - McKinzie, Page B AU - Parsons, Barbara L Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 409 EP - 418 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Mutagens KW - Age KW - Animal models KW - Carcinogens KW - Mutants KW - Mutagenesis KW - Rats KW - Body weight KW - Colon KW - Polymerase chain reaction KW - body weight KW - DNA adducts KW - Data processing KW - Tumors KW - K-Ras protein KW - Azoxymethane KW - Carcinogenesis KW - DNA KW - Codons KW - Mutation KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - N 14820:DNA Metabolism & Structure KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020838704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Accumulation+of+K-Ras+codon+12+mutations+in+the+F344+rat+distal+colon+following+azoxymethane+exposure&rft.au=McKinzie%2C+Page+B%3BParsons%2C+Barbara+L&rft.aulast=McKinzie&rft.aufirst=Page&rft.date=2011-06-01&rft.volume=52&rft.issue=5&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20644 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20644/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Mutagens; DNA adducts; Age; Data processing; Animal models; Tumors; Carcinogens; Mutagenesis; K-Ras protein; Colon; Body weight; Azoxymethane; Carcinogenesis; Codons; Polymerase chain reaction; Mutation; Rats; DNA; body weight; Mutants DO - http://dx.doi.org/10.1002/em.20644 ER - TY - JOUR T1 - Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure AN - 1020837748; 15112473 AB - Objective: Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure. Methods: Mice were exposed by pharyngeal aspiration to 40- mu g CNT and harvested 24 hours, 7 days, and 28 days postexposure for measurements of whole blood, lung and extrapulmonary tissue gene expression, blood and bronchoalveolar lavage (BAL) differentials, and serum protein profiling. Results: Early effects included increased inflammatory blood gene expression and serum cytokines followed by an acute phase response (eg, CRP, SAA-1, SAP). Beyond 24 hours, there was a consistent increase in blood and BAL eosinophils. At 28 day, serum acute phase proteins with immune function including complement C3, apolipoproteins A-I and A-II, and alpha sub(2)-macroglobulin were increased. Conclusions: Carbon nanotube exposure resulted in measurable systemic markers but lacked specificity to distinguish from other pulmonary exposures. JF - Journal of Occupational and Environmental Medicine AU - Erdely, A AU - Liston, A AU - Salmen-Muniz, R AU - Hulderman, T AU - Young, S-H AU - Zeidler-Erdely, P C AU - Castranova, V AU - Simeonova, P P AD - NIOSH/HELD/TMBB, 1095 Willowdale Rd, MS-3014, Morgantown, WV 26505, USA, efi4@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - S80 EP - S86 VL - 53 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Immune response KW - Lung KW - Mice KW - Occupational exposure KW - Proteins KW - nanotechnology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020837748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Identification+of+Systemic+Markers+from+A+Pulmonary+Carbon+Nanotube+Exposure&rft.au=Erdely%2C+A%3BListon%2C+A%3BSalmen-Muniz%2C+R%3BHulderman%2C+T%3BYoung%2C+S-H%3BZeidler-Erdely%2C+P+C%3BCastranova%2C+V%3BSimeonova%2C+P+P&rft.aulast=Erdely&rft.aufirst=A&rft.date=2011-06-01&rft.volume=53&rft.issue=&rft.spage=S80&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31821ad724 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Lung; Proteins; Mice; Immune response; Occupational exposure; nanotechnology DO - http://dx.doi.org/10.1097/JOM.0b013e31821ad724 ER - TY - JOUR T1 - Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature AN - 1017979110; 16712425 AB - Docosahexanoic acid (DHA) and arachidonic acid (ARA) are long chain essential fatty acids used as supplements in commercial infant formula. DHA/ARA deficient states are associated with adverse neurological outcomes in animals and humans. Preterm infants are at risk for DHA/ARA deficiency. A few clinical reports on the effects of fatty acid supplementation have shown benefit in preterm, low birth weight, and normal infants in the first year of life, whereas others did not. Studies in animals have reported shortened gestation, fetal growth retardation, reduced infant body mass, and increased fetal mortality with consumption of fatty acids during pregnancy. To understand the data that support fatty acid supplementation in infant formula, a review of the animal model literature was undertaken, to examine the effects of DHA/ARA on neurodevelopment, including the effects on visual acuity. Several points emerged from this review. (1) Animal studies indicate that requirements for DHA/ARA vary depending on developmental age. Alterations of the ratio of DHA/ARA can impact developmental outcome. (2) The available studies suggest that while supplementation of DHA/ARA in an appropriate ratio can increase tissue levels of these fatty acids in the brain and retina, tissues sensitive to depletion of fatty acids, the benefit of routine supplementation remains unclear. Few studies measure functional outcome relative to changes in physiologic pools of DHA/ARA after supplementation. (3) Animal literature does not support a clear long-term benefit of replenishing DHA/ARA tissue levels and administration of these fatty acids at concentrations above those in human milk suggests adverse effects on growth, survival, and neurodevelopment. Birth Defects Res (Part B) 92:240-250, 2011. ? 2011 Wiley-Liss, Inc. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Davis-Bruno, Karen AU - Tassinari, Melissa S Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 240 EP - 250 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 92 IS - 3 SN - 1542-9741, 1542-9741 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Growth rate KW - Mortality KW - Birth weight KW - Infant formulas KW - Data processing KW - Body mass KW - Breast milk KW - Animal models KW - Arachidonic acid KW - Fetuses KW - Supplementation KW - Pregnancy KW - Literature reviews KW - Reviews KW - Gestation KW - Fatty acids KW - Congenital defects KW - Side effects KW - Infants KW - N3 11003:Developmental neuroscience KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017979110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Essential+fatty+acid+supplementation+of+DHA+and+ARA+and+effects+on+neurodevelopment+across+animal+species%3A+a+review+of+the+literature&rft.au=Davis-Bruno%2C+Karen%3BTassinari%2C+Melissa+S&rft.aulast=Davis-Bruno&rft.aufirst=Karen&rft.date=2011-06-01&rft.volume=92&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429741&rft_id=info:doi/10.1002%2Fbdrb.20311 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20311/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Growth rate; Birth weight; Mortality; Infant formulas; Data processing; Body mass; Animal models; Breast milk; Arachidonic acid; Supplementation; Fetuses; Pregnancy; Literature reviews; Reviews; Gestation; Fatty acids; Congenital defects; Side effects; Infants DO - http://dx.doi.org/10.1002/bdrb.20311 ER - TY - JOUR T1 - Developmental toxicity of Citrus aurantium in rats AN - 1017979059; 16712422 AB - BACKGROUND: Ephedra was commonly used in herbal products marketed for weight loss until safety concerns forced its removal from products. Even before the ban, manufacturers had begun to replace ephedra with other compounds, including Citrus aurantium, or bitter orange. The major component in the bitter orange extract is synephrine which is chemically similar to ephedrine. The purpose of this study was to determine if relatively pure synephrine or synephrine present as a constituent of a bitter orange extract produced developmental toxicity in rats. METHOD: Sprague-Dawley rats were dosed daily by gavage with one of several different doses of synephrine from one of two different extracts. Caffeine was added to some doses. Animals were sacrificed on GD 21, and fetuses were examined for the presence of various developmental toxic endpoints. RESULTS AND CONCLUSION: At doses up to 100mg synephrine/kg body weight, there were no adverse effects on embryolethality, fetal weight, or incidences of gross, visceral, or skeletal abnormalities. There was a decrease in maternal weight at 50mg synephrine/kg body weight when given as the 6% synephrine extract with 25mg caffeine/kg body weight; there was also a decrease in maternal weight in the caffeine only group. This decrease in body weight may have been due to decreased food consumption which was also observed in these two groups. Overall, doses of up to 100mg synephrine/kg body weight did not produce developmental toxicity in Sprague-Dawley rats. Birth Defects Res (Part B) 92:216-223, 2011. ? 2011 Wiley-Liss, Inc. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Hansen, Deborah K AU - Juliar, Beth E AU - White, Gene E AU - Pellicore, Linda S AD - Division of Personalized Nutrition and Medicine, NCTR/FDA, Jefferson, Arkansas, deborah.hansen@fda.hhs.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 216 EP - 223 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 92 IS - 3 SN - 1542-9741, 1542-9741 KW - Toxicology Abstracts KW - Body weight KW - Body weight loss KW - Caffeine KW - Congenital defects KW - Ephedrine KW - Fetuses KW - Food consumption KW - Side effects KW - Toxicity KW - Citrus KW - Ephedra KW - Citrus aurantium KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017979059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Developmental+toxicity+of+Citrus+aurantium+in+rats&rft.au=Hansen%2C+Deborah+K%3BJuliar%2C+Beth+E%3BWhite%2C+Gene+E%3BPellicore%2C+Linda+S&rft.aulast=Hansen&rft.aufirst=Deborah&rft.date=2011-06-01&rft.volume=92&rft.issue=3&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429741&rft_id=info:doi/10.1002%2Fbdrb.20308 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bdrb.20308/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Body weight loss; Food consumption; Body weight; Congenital defects; Ephedrine; Caffeine; Toxicity; Side effects; Fetuses; Citrus; Ephedra; Citrus aurantium DO - http://dx.doi.org/10.1002/bdrb.20308 ER - TY - JOUR T1 - Does the small farm exemption cost lives? AN - 1017966886; 16691552 AB - Background Congress has exempted farms with fewer than 11 employees from enforcement of the Occupational Safety and Health Act. Three states (California, Oregon, and Washington) do not observe the exemption. Methods We compared rates of fatal occupational injury in agriculture, by year, in 1993-2007, in California, Oregon, and Washington (aggregated), and the remaining states (as two aggregated groups): those with, and those without, state-designed occupational safety and health programs. Results Fatality rates were approximately 1.6 to 3 times as high in both groups of states observing the small farm exemption as in the group of three states not observing it. Comparisons excluding the agriculture industry showed weaker differences. Conclusions The three states' opting out of the small farm exemption may have had substantial direct effects. They may also reflect and/or encourage a generally more effective approach to occupational health and safety. Although alternative explanations must be considered, the stakes are high in terms of injury and loss of life; further investigation seems urgently indicated. Am. J. Ind. Med. 54:461-466, 2011. ? 2011 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Somervell, Philip D AU - Conway, George A AD - Epidemiologist Alaska Pacific Regional Office, National Institute for Occupational Safety and Health, Anchorage, Alaska, gjx7@cdc.gov Y1 - 2011/06// PY - 2011 DA - Jun 2011 SP - 461 EP - 466 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 6 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - USA, Washington KW - Mortality KW - Injuries KW - farms KW - Congress KW - Occupational safety KW - agriculture KW - USA, California KW - small farms KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Does+the+small+farm+exemption+cost+lives%3F&rft.au=Somervell%2C+Philip+D%3BConway%2C+George+A&rft.aulast=Somervell&rft.aufirst=Philip&rft.date=2011-06-01&rft.volume=54&rft.issue=6&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20931 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20931/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Mortality; Injuries; Congress; farms; Occupational safety; agriculture; small farms; Occupational health; USA, Washington; USA, California DO - http://dx.doi.org/10.1002/ajim.20931 ER - TY - CPAPER T1 - Development of a Foodborne Bacterial Pathogen PCR Electrospray Ionization Mass Spectrometry Biosensor Detection Assay for Rapid, High-Throughput Food Testing T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313056503; 6038812 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Burrows, E AU - Allard, S AU - Bell, R AU - Allard, M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Mass spectroscopy KW - Pathogens KW - Biosensors KW - Food KW - Polymerase chain reaction KW - Disease detection KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313056503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Development+of+a+Foodborne+Bacterial+Pathogen+PCR+Electrospray+Ionization+Mass+Spectrometry+Biosensor+Detection+Assay+for+Rapid%2C+High-Throughput+Food+Testing&rft.au=Burrows%2C+E%3BAllard%2C+S%3BBell%2C+R%3BAllard%2C+M&rft.aulast=Burrows&rft.aufirst=E&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Plasmid Mediated Antimicrobial Resistance and Virulence in Salmonella enterica Serovar Typhimurium T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313055172; 6038276 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Han, J AU - Lynne, A AU - Nayak, R AU - Foley, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - antimicrobial agents KW - Virulence KW - Antimicrobial resistance KW - Plasmids KW - Anadromous species KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313055172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Plasmid+Mediated+Antimicrobial+Resistance+and+Virulence+in+Salmonella+enterica+Serovar+Typhimurium&rft.au=Han%2C+J%3BLynne%2C+A%3BNayak%2C+R%3BFoley%2C+S&rft.aulast=Han&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Prediction of Salmonella Serotypes Based on the Profiles of Pulsed-Field Gel Electrophoresis T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313054058; 6037769 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Zou, W AU - Lin, W-J AU - Chen, H-C AU - Chen, J AU - Keys, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Electrophoresis KW - Serotypes KW - Pulsed-field gel electrophoresis KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313054058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Prediction+of+Salmonella+Serotypes+Based+on+the+Profiles+of+Pulsed-Field+Gel+Electrophoresis&rft.au=Zou%2C+W%3BLin%2C+W-J%3BChen%2C+H-C%3BChen%2C+J%3BKeys%2C+C&rft.aulast=Zou&rft.aufirst=W&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification and Phenotypic Analysis of SdiA in Cronobacter sakazakii BAA894 T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313050306; 6036591 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Gopinathrao, G AU - Franco, A AU - Carter, L AU - Kothary, M AU - Grim, C AU - Jarvis, K AU - Hu, L. AU - Tall, B AU - Strain, E Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Identification+and+Phenotypic+Analysis+of+SdiA+in+Cronobacter+sakazakii+BAA894&rft.au=Gopinathrao%2C+G%3BFranco%2C+A%3BCarter%2C+L%3BKothary%2C+M%3BGrim%2C+C%3BJarvis%2C+K%3BHu%2C+L.%3BTall%2C+B%3BStrain%2C+E&rft.aulast=Gopinathrao&rft.aufirst=G&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of Salmonella Isolated from Retail Meats: The National Antimicrobial Resistance Monitoring System (NARMS) 2009 T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313050175; 6036588 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Ayers, S AU - Tong, E AU - Friedman, S AU - Abbott, J AU - Mcdermott, P AU - Zhao, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - meat KW - antimicrobial agents KW - Meat KW - Antimicrobial resistance KW - Monitoring systems KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Characterization+of+Salmonella+Isolated+from+Retail+Meats%3A+The+National+Antimicrobial+Resistance+Monitoring+System+%28NARMS%29+2009&rft.au=Ayers%2C+S%3BTong%2C+E%3BFriedman%2C+S%3BAbbott%2C+J%3BMcdermott%2C+P%3BZhao%2C+S&rft.aulast=Ayers&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparative Analysis of Vibrio parahaemolyticus Isolates from Oysters and Patients T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313050130; 6036587 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Jones, J AU - Calci, K AU - Depaola, A AU - Cooper, K AU - Lafon, P AU - Garrett, N Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - oysters KW - Pathogenic bacteria KW - Vibrio parahaemolyticus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Comparative+Analysis+of+Vibrio+parahaemolyticus+Isolates+from+Oysters+and+Patients&rft.au=Jones%2C+J%3BCalci%2C+K%3BDepaola%2C+A%3BCooper%2C+K%3BLafon%2C+P%3BGarrett%2C+N&rft.aulast=Jones&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Investigation Of The Possible Pathogenic Role Of Moraxella Catarrhalis Denitrification In An In Vitro Bacterial - Human Host Cell Interaction System T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313015895; 6037841 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Wang, W AU - Mocca, B AU - Hansen, E AU - Fang, F Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Denitrification KW - Cell interactions KW - Moraxella catarrhalis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Investigation+Of+The+Possible+Pathogenic+Role+Of+Moraxella+Catarrhalis+Denitrification+In+An+In+Vitro+Bacterial+-+Human+Host+Cell+Interaction+System&rft.au=Wang%2C+W%3BMocca%2C+B%3BHansen%2C+E%3BFang%2C+F&rft.aulast=Wang&rft.aufirst=W&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identification of Novel Real-TimePCR Targets for Escherichia coli O157:H7 and Non-O157 STEC T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313015373; 6037634 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Li, B. AU - Chen, J-Q AU - Leclerc, J Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Public health KW - Epidemiology KW - Microbiology KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Identification+of+Novel+Real-TimePCR+Targets+for+Escherichia+coli+O157%3AH7+and+Non-O157+STEC&rft.au=Li%2C+B.%3BChen%2C+J-Q%3BLeclerc%2C+J&rft.aulast=Li&rft.aufirst=B.&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparative Evaluation Of Multilocus Virulence Sequence Typing, Multilocus Sequence Typing And Pulsed Field Gel Electrophoresis For Subtyping L. Monocytogenes T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313015299; 6037633 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Chen, Y AU - Son, I AU - Gonzalez-Escalona, N AU - Knabel, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Electrophoresis KW - Gel electrophoresis KW - Virulence KW - multilocus sequence typing KW - Typing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Comparative+Evaluation+Of+Multilocus+Virulence+Sequence+Typing%2C+Multilocus+Sequence+Typing+And+Pulsed+Field+Gel+Electrophoresis+For+Subtyping+L.+Monocytogenes&rft.au=Chen%2C+Y%3BSon%2C+I%3BGonzalez-Escalona%2C+N%3BKnabel%2C+S&rft.aulast=Chen&rft.aufirst=Y&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Rapid Detection of Salmonella spp. from Common Insect Vectors T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1313015204; 6037632 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Burrows, E AU - Brown, E AU - Allard, M AU - Blazar, J AU - Datta, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - insects KW - Vectors KW - Aquatic insects KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Rapid+Detection+of+Salmonella+spp.+from+Common+Insect+Vectors&rft.au=Burrows%2C+E%3BBrown%2C+E%3BAllard%2C+M%3BBlazar%2C+J%3BDatta%2C+S&rft.aulast=Burrows&rft.aufirst=E&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of Equivalency of MDCK Cells Enrichment and MilliPROBE Methods to the Compendial Method for the Detection of Mycoplasma Contamination T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312983838; 6037509 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Parveen, S AU - Landsman, S AU - Kaur, S AU - Wilsondavid, S AU - Kong, H AU - Volokhov, D AU - Chizhikov, V AU - Kenney, J AU - Mccormick, W AU - Gupta, R Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Contamination KW - Mycoplasma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Evaluation+of+Equivalency+of+MDCK+Cells+Enrichment+and+MilliPROBE+Methods+to+the+Compendial+Method+for+the+Detection+of+Mycoplasma+Contamination&rft.au=Parveen%2C+S%3BLandsman%2C+S%3BKaur%2C+S%3BWilsondavid%2C+S%3BKong%2C+H%3BVolokhov%2C+D%3BChizhikov%2C+V%3BKenney%2C+J%3BMccormick%2C+W%3BGupta%2C+R&rft.aulast=Parveen&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparative Evaluation of Genomic Based Methods and Compendial Broth Culture Method for Rapid detection & identification of Mycoplasma contamination T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312981791; 6037507 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Wilson David, S. AU - Parveen, S AU - Kaur, S AU - Landsman, S AU - Kong, H AU - Kenney, J AU - Mccormick, W AU - Gupta, R Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Contamination KW - genomics KW - Mycoplasma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Comparative+Evaluation+of+Genomic+Based+Methods+and+Compendial+Broth+Culture+Method+for+Rapid+detection+%26amp%3B+identification+of+Mycoplasma+contamination&rft.au=Wilson+David%2C+S.%3BParveen%2C+S%3BKaur%2C+S%3BLandsman%2C+S%3BKong%2C+H%3BKenney%2C+J%3BMccormick%2C+W%3BGupta%2C+R&rft.aulast=Wilson+David&rft.aufirst=S.&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Estrogen Increases Resistance of Candida albicans to Soluble Inhibitors Produced by Probiotic Lactobacilli T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312974918; 6036889 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Johnson, S AU - Wagner, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - estrogens KW - probiotics KW - Estrogens KW - Sex hormones KW - Inhibitors KW - Lactobacillus KW - Candida albicans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Estrogen+Increases+Resistance+of+Candida+albicans+to+Soluble+Inhibitors+Produced+by+Probiotic+Lactobacilli&rft.au=Johnson%2C+S%3BWagner%2C+D&rft.aulast=Johnson&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparison of Microbial and Molecular Methods for Salmonella Detection in Tomatoes under Varying Preenrichment Conditions T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312974392; 6036567 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Allard, S AU - Zheng, J AU - Hammack, T AU - Allard, M AU - Burrows, E AU - Gonzalez-Escalona, N AU - Brown, E Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Anadromous species KW - Lycopersicon esculentum KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Comparison+of+Microbial+and+Molecular+Methods+for+Salmonella+Detection+in+Tomatoes+under+Varying+Preenrichment+Conditions&rft.au=Allard%2C+S%3BZheng%2C+J%3BHammack%2C+T%3BAllard%2C+M%3BBurrows%2C+E%3BGonzalez-Escalona%2C+N%3BBrown%2C+E&rft.aulast=Allard&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Salmonella spp. detection in produce by Quantitative Real-Time PCR, Quantitative Reverse Transcriptase Real-Time PCR, and conventional microbiological method by the U.S. Food and Drug Administration T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312974345; 6036565 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Zhang, G AU - Brown, E AU - Gonzalez-Escalona, N Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - USA KW - Drugs KW - Polymerase chain reaction KW - RNA-directed DNA polymerase KW - Nucleotide sequence KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Salmonella+spp.+detection+in+produce+by+Quantitative+Real-Time+PCR%2C+Quantitative+Reverse+Transcriptase+Real-Time+PCR%2C+and+conventional+microbiological+method+by+the+U.S.+Food+and+Drug+Administration&rft.au=Zhang%2C+G%3BBrown%2C+E%3BGonzalez-Escalona%2C+N&rft.aulast=Zhang&rft.aufirst=G&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Combined Analysis of Multiple PFGE Enzymes Predicts Source Reservoirs for Human Outbreak Strains of Salmonella Enteritidis and Salmonella Typhimurium T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312974313; 6036564 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Son, I AU - Zheng, J AU - Keys, C AU - Brown, E AU - Zhao, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - outbreaks KW - Enzymes KW - Reservoirs KW - Anadromous species KW - Strains KW - Salmonella typhimurium KW - Salmonella enteritidis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Combined+Analysis+of+Multiple+PFGE+Enzymes+Predicts+Source+Reservoirs+for+Human+Outbreak+Strains+of+Salmonella+Enteritidis+and+Salmonella+Typhimurium&rft.au=Son%2C+I%3BZheng%2C+J%3BKeys%2C+C%3BBrown%2C+E%3BZhao%2C+S&rft.aulast=Son&rft.aufirst=I&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cladistic Method Discovers Targets that Identify and Discriminate Amongst the Top Centers for Disease Control and Prevention Serotypes of Salmonella Enterica T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312972374; 6039327 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Lienau, E AU - Blazar, J AU - Datta, S AU - Stones, R AU - Wang, C AU - Musser, S AU - Brown, E AU - Allard, M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - disease control KW - prevention KW - cladistics KW - Serotypes KW - Disease control KW - Anadromous species KW - Cladistics KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312972374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Cladistic+Method+Discovers+Targets+that+Identify+and+Discriminate+Amongst+the+Top+Centers+for+Disease+Control+and+Prevention+Serotypes+of+Salmonella+Enterica&rft.au=Lienau%2C+E%3BBlazar%2C+J%3BDatta%2C+S%3BStones%2C+R%3BWang%2C+C%3BMusser%2C+S%3BBrown%2C+E%3BAllard%2C+M&rft.aulast=Lienau&rft.aufirst=E&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Molecular Markers Complementing the 16S rRNA Gene Based Phylogenetic Analysis and Identification of Mycoplasmataceae Species: the Beta Subunit of RNA Polymerase Gene (rpoB) and the 16S-23S rRNA Intergenic Transcribed Spacer Region (ITS) T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312957691; 6038648 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Volokhov, D AU - Kong, H AU - Chizhikov, V Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Spacer region KW - rRNA KW - rRNA 16S KW - RpoB protein KW - DNA-directed RNA polymerase KW - Phylogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Molecular+Markers+Complementing+the+16S+rRNA+Gene+Based+Phylogenetic+Analysis+and+Identification+of+Mycoplasmataceae+Species%3A+the+Beta+Subunit+of+RNA+Polymerase+Gene+%28rpoB%29+and+the+16S-23S+rRNA+Intergenic+Transcribed+Spacer+Region+%28ITS%29&rft.au=Volokhov%2C+D%3BKong%2C+H%3BChizhikov%2C+V&rft.aulast=Volokhov&rft.aufirst=D&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cloning and expression of a Y. pestis F1-V fusion protein into Salmonella Typhi Ty21a: Part of a combination oral anthrax-plague vaccine T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312957599; 6038646 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Foote, M AU - Filipova, S AU - Osorio, M AU - Kopecko, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - vaccines KW - Vaccines KW - Fusion protein KW - Anadromous species KW - Disease control KW - Salmonella typhi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Cloning+and+expression+of+a+Y.+pestis+F1-V+fusion+protein+into+Salmonella+Typhi+Ty21a%3A+Part+of+a+combination+oral+anthrax-plague+vaccine&rft.au=Foote%2C+M%3BFilipova%2C+S%3BOsorio%2C+M%3BKopecko%2C+D&rft.aulast=Foote&rft.aufirst=M&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Genotypic and Transcriptomic Analysis of the Listeria monocytogenes Strains Involved in Gastroenteritis and Invasive Human Listeriosis T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312956487; 6038485 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Laksanalamai, P AU - Mammel, M AU - Datta, A Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - gastroenteritis KW - Listeriosis KW - Gastroenteritis KW - Strains KW - Listeria monocytogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Genotypic+and+Transcriptomic+Analysis+of+the+Listeria+monocytogenes+Strains+Involved+in+Gastroenteritis+and+Invasive+Human+Listeriosis&rft.au=Laksanalamai%2C+P%3BMammel%2C+M%3BDatta%2C+A&rft.aulast=Laksanalamai&rft.aufirst=P&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Plasmid Replicon Typing of Historical Salmonella Newport: 1940-2000 T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312955823; 6038449 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Singh, A AU - Zhao, S AU - Sabo, J AU - Abbott, J AU - Fields, P AU - Mcdermott, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Historical account KW - Typing KW - Plasmids KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Plasmid+Replicon+Typing+of+Historical+Salmonella+Newport%3A+1940-2000&rft.au=Singh%2C+A%3BZhao%2C+S%3BSabo%2C+J%3BAbbott%2C+J%3BFields%2C+P%3BMcdermott%2C+P&rft.aulast=Singh&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - High-Throughput, de novo, SNP Discovery in Salmonella enterica: Confirmation of Tiling Array Data Using Conventional Sanger Sequencing T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312955354; 6037514 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Gangiredla, J AU - Mammel, M AU - Jackson, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Data processing KW - Single-nucleotide polymorphism KW - Anadromous species KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=High-Throughput%2C+de+novo%2C+SNP+Discovery+in+Salmonella+enterica%3A+Confirmation+of+Tiling+Array+Data+Using+Conventional+Sanger+Sequencing&rft.au=Gangiredla%2C+J%3BMammel%2C+M%3BJackson%2C+S&rft.aulast=Gangiredla&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Norfloxacin Modification by a Microbacterium Strain and Subsequent Degradation by a Candida Strain from a Wastewater Treatment Plant T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312946040; 6039195 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Kim, D-W AU - Heinze, T AU - Kim, B-S AU - Schnackenberg, L AU - Sutherland, J Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Degradation KW - Wastewater treatment KW - Norfloxacin KW - Strains KW - Candida KW - Microbacterium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312946040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Norfloxacin+Modification+by+a+Microbacterium+Strain+and+Subsequent+Degradation+by+a+Candida+Strain+from+a+Wastewater+Treatment+Plant&rft.au=Kim%2C+D-W%3BHeinze%2C+T%3BKim%2C+B-S%3BSchnackenberg%2C+L%3BSutherland%2C+J&rft.aulast=Kim&rft.aufirst=D-W&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of nidA Mutant in the Degradation of Polycyclic Aromatic Hydrocarbons by Mycobacterium Vanbaalenii PYR-1 T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312945886; 6039194 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Kim, S-J AU - Kweon, O AU - Kim, D AU - Song, J AU - Cerniglia, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Degradation KW - polycyclic aromatic hydrocarbons KW - Mutants KW - Polycyclic aromatic hydrocarbons KW - Aromatic hydrocarbons KW - Mycobacterium vanbaalenii UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312945886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Analysis+of+nidA+Mutant+in+the+Degradation+of+Polycyclic+Aromatic+Hydrocarbons+by+Mycobacterium+Vanbaalenii+PYR-1&rft.au=Kim%2C+S-J%3BKweon%2C+O%3BKim%2C+D%3BSong%2C+J%3BCerniglia%2C+C&rft.aulast=Kim&rft.aufirst=S-J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Differential Detection of Shigella spp. and Enteroinvasive E. coli by Real-Time PCR T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312944882; 6038541 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Chen, K-S AU - Cheng, C-M AU - Lin, W Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Polymerase chain reaction KW - Nucleotide sequence KW - Escherichia coli KW - Shigella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312944882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Differential+Detection+of+Shigella+spp.+and+Enteroinvasive+E.+coli+by+Real-Time+PCR&rft.au=Chen%2C+K-S%3BCheng%2C+C-M%3BLin%2C+W&rft.aulast=Chen&rft.aufirst=K-S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - NARMS: Surveillance of Multidrug Resistant Enteric Pathogens in Animals and Humans T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312942540; 6039351 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - McDermott, Patrick Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Pathogens KW - Multidrug resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312942540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=NARMS%3A+Surveillance+of+Multidrug+Resistant+Enteric+Pathogens+in+Animals+and+Humans&rft.au=McDermott%2C+Patrick&rft.aulast=McDermott&rft.aufirst=Patrick&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of O-antigen Molecular Serotypes of the Neonatal Meningitis Bacteria, Cronobacter spp. T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312940025; 6038490 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Jarvis, K AU - Grim, C AU - Franco, A AU - Hu, L. AU - Gopinath, G AU - Sathyamoorthy, V AU - Kotewicz, M AU - Kothary, M AU - Lee, C AU - Sadowski, J AU - Tall, B Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Neonates KW - Serotypes KW - Meningitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312940025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Characterization+of+O-antigen+Molecular+Serotypes+of+the+Neonatal+Meningitis+Bacteria%2C+Cronobacter+spp.&rft.au=Jarvis%2C+K%3BGrim%2C+C%3BFranco%2C+A%3BHu%2C+L.%3BGopinath%2C+G%3BSathyamoorthy%2C+V%3BKotewicz%2C+M%3BKothary%2C+M%3BLee%2C+C%3BSadowski%2C+J%3BTall%2C+B&rft.aulast=Jarvis&rft.aufirst=K&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evolution of RepFIB Virulence Plasmids of Cronobacter spp. T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312939972; 6038489 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Grim, C AU - Jarvis, K AU - Franco, A AU - Hu, L. AU - Gopinath, G AU - Sathyamoorthy, V AU - Kotewicz, M AU - Kothary, M AU - Lee, C AU - Sadowski, J AU - Tall, B Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Virulence KW - Plasmids KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312939972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Evolution+of+RepFIB+Virulence+Plasmids+of+Cronobacter+spp.&rft.au=Grim%2C+C%3BJarvis%2C+K%3BFranco%2C+A%3BHu%2C+L.%3BGopinath%2C+G%3BSathyamoorthy%2C+V%3BKotewicz%2C+M%3BKothary%2C+M%3BLee%2C+C%3BSadowski%2C+J%3BTall%2C+B&rft.aulast=Grim&rft.aufirst=C&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Anomalous Transcriptional Regulation of Fimbrial Gene fim3 in Bordetella pertussis T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312939032; 6037532 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Chen, Q AU - Nahas-Vigon, J AU - Merkel, T AU - Stibitz, S AU - Decker, K AU - Hinton, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Transcription KW - Gene regulation KW - Pertussis KW - Bordetella pertussis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312939032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Anomalous+Transcriptional+Regulation+of+Fimbrial+Gene+fim3+in+Bordetella+pertussis&rft.au=Chen%2C+Q%3BNahas-Vigon%2C+J%3BMerkel%2C+T%3BStibitz%2C+S%3BDecker%2C+K%3BHinton%2C+D&rft.aulast=Chen&rft.aufirst=Q&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In situ Evaluation of Naturally-occurring Epiphytic Bacillus in Reducing Carriage of Salmonella Newport on Whole Tomato Plants T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312936651; 6036563 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Zheng, J AU - Allard, S AU - Enurah, A AU - Strain, E AU - Blodgett, R AU - Brown, E AU - Millner, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Anadromous species KW - Lycopersicon esculentum KW - Bacillus KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312936651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=In+situ+Evaluation+of+Naturally-occurring+Epiphytic+Bacillus+in+Reducing+Carriage+of+Salmonella+Newport+on+Whole+Tomato+Plants&rft.au=Zheng%2C+J%3BAllard%2C+S%3BEnurah%2C+A%3BStrain%2C+E%3BBlodgett%2C+R%3BBrown%2C+E%3BMillner%2C+P&rft.aulast=Zheng&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A PCR Assay for the Speciation of Fungi Isolated from Milk Thistle Supplements T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312934276; 6038802 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Rivera calo, J AU - Tournas, V Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Fungi KW - Milk KW - Speciation KW - Polymerase chain reaction KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312934276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=A+PCR+Assay+for+the+Speciation+of+Fungi+Isolated+from+Milk+Thistle+Supplements&rft.au=Rivera+calo%2C+J%3BTournas%2C+V&rft.aulast=Rivera+calo&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Proteome Analysis of Outer Membrane Vesicles Secreted by Cronobacter spp. T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312932485; 6038952 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Kothary, M AU - Gopinath, G AU - Franco, A AU - Grim, C AU - Hu, L. AU - Jarvis, K AU - Tall, B Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Outer membranes KW - Membrane vesicles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312932485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Proteome+Analysis+of+Outer+Membrane+Vesicles+Secreted+by+Cronobacter+spp.&rft.au=Kothary%2C+M%3BGopinath%2C+G%3BFranco%2C+A%3BGrim%2C+C%3BHu%2C+L.%3BJarvis%2C+K%3BTall%2C+B&rft.aulast=Kothary&rft.aufirst=M&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Concurrent Oral Administration of Ciprofloxacin on the Immunogenicity of a Live, Oral Anthrax Vaccine T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312930391; 6038636 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Osorio, M AU - Hanisch, B AU - Filippova, S AU - Foote, M AU - Panayiotou, M AU - Kopecko, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - anthrax KW - vaccines KW - immunogenicity KW - Anthrax KW - Ciprofloxacin KW - Vaccines KW - Oral administration KW - Immunogenicity KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Effect+of+Concurrent+Oral+Administration+of+Ciprofloxacin+on+the+Immunogenicity+of+a+Live%2C+Oral+Anthrax+Vaccine&rft.au=Osorio%2C+M%3BHanisch%2C+B%3BFilippova%2C+S%3BFoote%2C+M%3BPanayiotou%2C+M%3BKopecko%2C+D&rft.aulast=Osorio&rft.aufirst=M&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using a PCR-based Serotyping Method to Identify Salmonella sp. From Food Matrices T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312930096; 6037053 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Jean-Gilles Beaubrun, J AU - Ewing, L AU - Dudley, K AU - Hanes, D AU - Cheng, C AU - Chen, K AU - Agpaoa, M AU - Huang, M AU - Du, J. AU - Williams-Hill, D AU - Wang, H AU - Dickey, E AU - Jacobson, A AU - Hamilton, B Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Serotyping KW - Food KW - Anadromous species KW - Polymerase chain reaction KW - Nucleotide sequence KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Using+a+PCR-based+Serotyping+Method+to+Identify+Salmonella+sp.+From+Food+Matrices&rft.au=Jean-Gilles+Beaubrun%2C+J%3BEwing%2C+L%3BDudley%2C+K%3BHanes%2C+D%3BCheng%2C+C%3BChen%2C+K%3BAgpaoa%2C+M%3BHuang%2C+M%3BDu%2C+J.%3BWilliams-Hill%2C+D%3BWang%2C+H%3BDickey%2C+E%3BJacobson%2C+A%3BHamilton%2C+B&rft.aulast=Jean-Gilles+Beaubrun&rft.aufirst=J&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of Escherichia coli and Shigella Strain Relationships Based on Topological Data Analysis T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312930063; 6039246 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Mammel, M AU - Klocke, J AU - Carlsson, G AU - Singh, G AU - Lacher, D AU - Jackson, S AU - Patel, I AU - Lewis, J AU - Gangiredla, J AU - Elkins, C AU - Lum, P Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Data processing KW - Strains KW - Escherichia coli KW - Shigella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Analysis+of+Escherichia+coli+and+Shigella+Strain+Relationships+Based+on+Topological+Data+Analysis&rft.au=Mammel%2C+M%3BKlocke%2C+J%3BCarlsson%2C+G%3BSingh%2C+G%3BLacher%2C+D%3BJackson%2C+S%3BPatel%2C+I%3BLewis%2C+J%3BGangiredla%2C+J%3BElkins%2C+C%3BLum%2C+P&rft.aulast=Mammel&rft.aufirst=M&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PATRN, A Web-Based System for the Integration, Analysis, Visualization, and Sharing of Data of Food-Borne Pathogens T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312929934; 6039242 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Mccardell, B AU - Gopinath, G AU - Tall, B AU - Jain, R AU - Hari, K AU - Kothary, M AU - Datta, A AU - Franco, A AU - Mammel, M AU - Jarvis, K AU - Grim, C AU - Sathyamoorthy, V AU - Hu, L. AU - Patel, I AU - Jackson, S AU - Kotewicz, M AU - Leclerc, J AU - Mcdermott, P AU - Solomotis, M AU - Wekell, M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Food contamination KW - Integration KW - Data processing KW - Pathogens KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312929934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=PATRN%2C+A+Web-Based+System+for+the+Integration%2C+Analysis%2C+Visualization%2C+and+Sharing+of+Data+of+Food-Borne+Pathogens&rft.au=Mccardell%2C+B%3BGopinath%2C+G%3BTall%2C+B%3BJain%2C+R%3BHari%2C+K%3BKothary%2C+M%3BDatta%2C+A%3BFranco%2C+A%3BMammel%2C+M%3BJarvis%2C+K%3BGrim%2C+C%3BSathyamoorthy%2C+V%3BHu%2C+L.%3BPatel%2C+I%3BJackson%2C+S%3BKotewicz%2C+M%3BLeclerc%2C+J%3BMcdermott%2C+P%3BSolomotis%2C+M%3BWekell%2C+M&rft.aulast=Mccardell&rft.aufirst=B&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Next-Generation Sequencing Provides High Resolution Clustering of Food and Clinical Sources During a Foodborne Outbreak of Salmonellosis T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312929417; 6037204 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Lienau, E AU - Strain, E AU - Wang, C AU - Cao, G AU - Zheng, J AU - Meng, J AU - Ottesen, A AU - Keys, C AU - Stones, R AU - Hammack, T AU - Musser, S AU - Brown, E AU - Allard, M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - food-borne diseases KW - Food contamination KW - Food sources KW - Salmonellosis KW - Anadromous species KW - Salmonidae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312929417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Next-Generation+Sequencing+Provides+High+Resolution+Clustering+of+Food+and+Clinical+Sources+During+a+Foodborne+Outbreak+of+Salmonellosis&rft.au=Lienau%2C+E%3BStrain%2C+E%3BWang%2C+C%3BCao%2C+G%3BZheng%2C+J%3BMeng%2C+J%3BOttesen%2C+A%3BKeys%2C+C%3BStones%2C+R%3BHammack%2C+T%3BMusser%2C+S%3BBrown%2C+E%3BAllard%2C+M&rft.aulast=Lienau&rft.aufirst=E&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Careers at the Food and Drug Administration T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312927409; 6037798 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Stibitz, Scott Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Drugs KW - careers KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312927409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Careers+at+the+Food+and+Drug+Administration&rft.au=Stibitz%2C+Scott&rft.aulast=Stibitz&rft.aufirst=Scott&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Initial Post Exposure Response of Human Epidermal Keratinocyte Cells to Bacillus anthracis Spores T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312919281; 6036866 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Sung, K AU - Khan, S AU - Wagner, D AU - Johnson, S AU - Nawaz, M AU - Cerniglia, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Keratinocytes KW - Spores KW - Bacillus anthracis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312919281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Initial+Post+Exposure+Response+of+Human+Epidermal+Keratinocyte+Cells+to+Bacillus+anthracis+Spores&rft.au=Sung%2C+K%3BKhan%2C+S%3BWagner%2C+D%3BJohnson%2C+S%3BNawaz%2C+M%3BCerniglia%2C+C&rft.aulast=Sung&rft.aufirst=K&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Campylobacter jejuni Invasion of Host Cells Involves Activation of Src Kinase, PI3 Kinase, and the Dynactin Complex T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312911015; 6038612 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Fukunaga, H AU - Wai, T AU - Kopecko, D Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - invasions KW - 1-Phosphatidylinositol 3-kinase KW - Src protein KW - dynactin KW - Campylobacter jejuni UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Campylobacter+jejuni+Invasion+of+Host+Cells+Involves+Activation+of+Src+Kinase%2C+PI3+Kinase%2C+and+the+Dynactin+Complex&rft.au=Fukunaga%2C+H%3BWai%2C+T%3BKopecko%2C+D&rft.aulast=Fukunaga&rft.aufirst=H&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Genomic Analysis of Salmonella Enteritidis Associated with the 2010 Multistate Outbreak of Shell Eggs Reveals Multiple Distinct Genotypes T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312908940; 6037741 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Jackson, S AU - Patel, I AU - Gangiredla, J AU - Elkins, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - outbreaks KW - Genotypes KW - Eggs KW - Genomic analysis KW - Shells KW - Anadromous species KW - Salmonella enteritidis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312908940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=A+Genomic+Analysis+of+Salmonella+Enteritidis+Associated+with+the+2010+Multistate+Outbreak+of+Shell+Eggs+Reveals+Multiple+Distinct+Genotypes&rft.au=Jackson%2C+S%3BPatel%2C+I%3BGangiredla%2C+J%3BElkins%2C+C&rft.aulast=Jackson&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Multiple-locus Variable-number Tandem Repeat Analysis Of Salmonella Enterica Serotype Enteritidis Isolated From The Recent Egg-associated Salmonella Outbreak T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312908738; 6037735 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Gebru, S AU - Leclerc, J AU - Mammel, M AU - Elkins, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - outbreaks KW - Serotypes KW - Anadromous species KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312908738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Multiple-locus+Variable-number+Tandem+Repeat+Analysis+Of+Salmonella+Enterica+Serotype+Enteritidis+Isolated+From+The+Recent+Egg-associated+Salmonella+Outbreak&rft.au=Gebru%2C+S%3BLeclerc%2C+J%3BMammel%2C+M%3BElkins%2C+C&rft.aulast=Gebru&rft.aufirst=S&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of human fecal supernatant on the enrofloxacin susceptibility of Escherichia coli ATCC 25922 T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312901904; 6036943 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Ahn, Y AU - Sung, K AU - Rafii, F AU - Cerniglia, C Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Fecal coliforms KW - Enrofloxacin KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Effect+of+human+fecal+supernatant+on+the+enrofloxacin+susceptibility+of+Escherichia+coli+ATCC+25922&rft.au=Ahn%2C+Y%3BSung%2C+K%3BRafii%2C+F%3BCerniglia%2C+C&rft.aulast=Ahn&rft.aufirst=Y&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Virulence Regulatory Factor Natural Mutant of Listeria monocytogenes T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312901581; 6036576 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Volokhov, D AU - Lye, D AU - Stelma, G AU - Hitchins, A Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Mutants KW - Virulence KW - Listeria monocytogenes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=A+Virulence+Regulatory+Factor+Natural+Mutant+of+Listeria+monocytogenes&rft.au=Volokhov%2C+D%3BLye%2C+D%3BStelma%2C+G%3BHitchins%2C+A&rft.aulast=Volokhov&rft.aufirst=D&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Phenotypic Microarray Characterization of Two Putative Virulence Plasmids of Cronobacter spp. T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312900050; 6038808 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Carter, L AU - Franco, A AU - Strain, E AU - Gopinath, G AU - Kothary, M AU - Tall, B Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Virulence KW - Plasmids KW - Phenotypes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312900050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Phenotypic+Microarray+Characterization+of+Two+Putative+Virulence+Plasmids+of+Cronobacter+spp.&rft.au=Carter%2C+L%3BFranco%2C+A%3BStrain%2C+E%3BGopinath%2C+G%3BKothary%2C+M%3BTall%2C+B&rft.aulast=Carter&rft.aufirst=L&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of a Panel of Mycoplasma Reference Strains for Evaluation of Alternative Mycoplasma Testing Methods T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312899719; 6038028 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Dabrazhynetskaya, A Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Strains KW - Mycoplasma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312899719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Development+of+a+Panel+of+Mycoplasma+Reference+Strains+for+Evaluation+of+Alternative+Mycoplasma+Testing+Methods&rft.au=Dabrazhynetskaya%2C+A&rft.aulast=Dabrazhynetskaya&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Salmonella Newport Positive Metagenome T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312898818; 6038129 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Ottesen, A AU - Arce, C AU - Strain, E AU - Wang, C AU - Burrows, E AU - Enurah, A AU - Zheng, J AU - Allard, S AU - Li, C. AU - Son, I AU - Keys, C AU - Belin, K AU - Allard, M AU - Brown, E AU - Stones, R AU - White, J AU - Cao, G AU - Rideout, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312898818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=A+Salmonella+Newport+Positive+Metagenome&rft.au=Ottesen%2C+A%3BArce%2C+C%3BStrain%2C+E%3BWang%2C+C%3BBurrows%2C+E%3BEnurah%2C+A%3BZheng%2C+J%3BAllard%2C+S%3BLi%2C+C.%3BSon%2C+I%3BKeys%2C+C%3BBelin%2C+K%3BAllard%2C+M%3BBrown%2C+E%3BStones%2C+R%3BWhite%2C+J%3BCao%2C+G%3BRideout%2C+S&rft.aulast=Ottesen&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PCR-RFLP Analysis of mutS and gnd Genes of Salmonella enterica Serovars Using Agilent 2100 Bioanalyzer T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312898658; 6037426 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Soler-Garcia, A AU - Defibaugh-Chavez, S AU - Babu, T AU - Brown, E Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Restriction fragment length polymorphism KW - Polymerase chain reaction KW - Anadromous species KW - Nucleotide sequence KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312898658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=PCR-RFLP+Analysis+of+mutS+and+gnd+Genes+of+Salmonella+enterica+Serovars+Using+Agilent+2100+Bioanalyzer&rft.au=Soler-Garcia%2C+A%3BDefibaugh-Chavez%2C+S%3BBabu%2C+T%3BBrown%2C+E&rft.aulast=Soler-Garcia&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Strains Of The Escherichia Coli O157:H7 Stepwise Evolutionary Model Exhibit Different IS629 Transposition Frequencies T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312897954; 6036584 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Rump, L AU - Gonzalez-Escalona, N AU - Fischer, M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Transposition KW - Evolution KW - Models KW - Strains KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312897954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Strains+Of+The+Escherichia+Coli+O157%3AH7+Stepwise+Evolutionary+Model+Exhibit+Different+IS629+Transposition+Frequencies&rft.au=Rump%2C+L%3BGonzalez-Escalona%2C+N%3BFischer%2C+M&rft.aulast=Rump&rft.aufirst=L&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of Antimicrobial Resistance and Serotype Prevalence of Salmonella Isolated from Wisconsin Dairy Cattle T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312897133; 6037135 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Marrero-Ortiz, R AU - Stemper, M AU - Hang, J AU - Lynne, A AU - David, D AU - Nayak, R AU - Farmer, D AU - Foley, S Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - USA, Wisconsin KW - Cattle KW - Dairies KW - antimicrobial agents KW - Serotypes KW - Antimicrobial resistance KW - Anadromous species KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312897133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Characterization+of+Antimicrobial+Resistance+and+Serotype+Prevalence+of+Salmonella+Isolated+from+Wisconsin+Dairy+Cattle&rft.au=Marrero-Ortiz%2C+R%3BStemper%2C+M%3BHang%2C+J%3BLynne%2C+A%3BDavid%2C+D%3BNayak%2C+R%3BFarmer%2C+D%3BFoley%2C+S&rft.aulast=Marrero-Ortiz&rft.aufirst=R&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of ciprofloxacin-resistant Salmonella enterica isolated from imported food T2 - 111th General Meeting of the American Society for Microbiology (ASM 2011) AN - 1312895968; 6036577 JF - 111th General Meeting of the American Society for Microbiology (ASM 2011) AU - Khan, A AU - Tatsuya, A AU - Nawaz, M AU - Summage West, C. AU - Cheng, C-M Y1 - 2011/05/21/ PY - 2011 DA - 2011 May 21 KW - Food KW - Anadromous species KW - Salmonella enterica UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312895968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.atitle=Characterization+of+ciprofloxacin-resistant+Salmonella+enterica+isolated+from+imported+food&rft.au=Khan%2C+A%3BTatsuya%2C+A%3BNawaz%2C+M%3BSummage+West%2C+C.%3BCheng%2C+C-M&rft.aulast=Khan&rft.aufirst=A&rft.date=2011-05-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/Browse.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Accurate mass and nuclear magnetic resonance identification of bisphenolic can coating migrants and their interference with liquid chromatography/tandem mass spectrometric analysis of bisphenol A AN - 901682951; 15267907 AB - Two unknown compounds were previously determined to be potential interferences in liquid chromatography/tandem mass spectrometry (LC/MS/MS) analysis of bisphenol A (BPA) in canned infant formula. Both yielded two identical MS/MS transitions to BPA. The identities of the unknowns were investigated using accurate mass LC/MS, LC/MS/MS, and elemental formula and structures proposed. Exact identities were confirmed through purification or synthesis followed by 1H and 13C nuclear magnetic resonance (NMR) experiments, as well as comparisons of one unknown with commercial standards. Comparisons of negative ion electrospray ionization (ESI) MS/MS and accurate mass spectra suggested both unknowns to be structurally identical (to BPA and each other). Positive ion ESI spectra confirmed both were larger molecules, suggesting that in the negative mode they likely fragmented to the BPA molecular ion in the source. Elemental composition of positive ion accurate mass spectra and NMR analysis concluded the unknowns were oxidized forms of the known epoxy can coating monomer, bisphenol A diglycidyl ether (BADGE). One of the unknowns, 2,2-[bis-4-(2,3-dihydroxypropoxy)phenyl]propane, commonly known as BADGE*2H2O, is widely reported as an epoxy-phenolic can coating migrant, but has not been suggested to interfere with the MS/MS analysis of BPA. The other unknown, 2-[4-(2,3-dihydroxypropoxy)phenyl]-2-[4'-hydroxyphenyl]propane, or the oxidized form of bisphenol A monoglycidyl ether (BAMGE*H2O), has not been previously reported in food or packaging. Published in 2011 by John Wiley & Sons, Ltd. JF - Rapid Communications in Mass Spectrometry AU - Anonymous Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 1336 EP - 1342 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1097-0231, 1097-0231 KW - Environment Abstracts KW - infant formulas KW - bisphenol A KW - migrants KW - Liquid chromatography KW - Mass spectrometry KW - NMR KW - Ethers KW - Coatings KW - Packaging KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901682951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+Communications+in+Mass+Spectrometry&rft.atitle=Accurate+mass+and+nuclear+magnetic+resonance+identification+of+bisphenolic+can+coating+migrants+and+their+interference+with+liquid+chromatography%2Ftandem+mass+spectrometric+analysis+of+bisphenol+A&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-05-15&rft.volume=25&rft.issue=9&rft.spage=1336&rft.isbn=&rft.btitle=&rft.title=Rapid+Communications+in+Mass+Spectrometry&rft.issn=10970231&rft_id=info:doi/10.1002%2Frcm.4997 L2 - http://onlinelibrary.wiley.com/doi/10.1002/rcm.4997/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - infant formulas; bisphenol A; migrants; Liquid chromatography; Mass spectrometry; Ethers; NMR; Packaging; Coatings DO - http://dx.doi.org/10.1002/rcm.4997 ER - TY - JOUR T1 - Kava extract, an herbal alternative for anxiety relief, potentiates acetaminophen-induced cytotoxicity in rat hepatic cells. AN - 865189535; 21397479 AB - The widely used over-the-counter analgesic acetaminophen (APAP) is the leading cause of acute liver failure in the United States and due to this high incidence, a recent FDA Advisory Board recommended lowering the maximum dose of APAP. Kava herbal dietary supplements have been implicated in several human liver failure cases leading to the ban of kava-containing products in several Western countries. In the US, the FDA has issued warnings about the potential adverse effects of kava, but kava dietary supplements are still available to consumers. In this study, we tested the potential of kava extract to potentiate APAP-induced hepatocyte cytotoxicity. In rat primary hepatocytes, co-treatment with kava and APAP caused 100% loss of cell viability, while the treatment of kava or APAP alone caused ∼50% and ∼30% loss of cell viability, respectively. APAP-induced glutathione (GSH) depletion was also potentiated by kava. Co-exposure to kava decreased cellular ATP concentrations, increased the formation of reactive oxygen species, and caused mitochondrial damage as indicated by a decrease in mitochondrial membrane potential. In addition, similar findings were obtained from a cultured rat liver cell line, clone-9. These observations indicate that kava potentiates APAP-induced cytotoxicity by increasing the magnitude of GSH depletion, resulting in oxidative stress and mitochondrial dysfunction, ultimately leading to cell death. These results highlight the potential for drug-dietary supplement interactions even with widely used over-the-counter drugs. Published by Elsevier GmbH. JF - Phytomedicine : international journal of phytotherapy and phytopharmacology AU - Yang, Xi AU - Salminen, William F AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2011/05/15/ PY - 2011 DA - 2011 May 15 SP - 592 EP - 600 VL - 18 IS - 7 KW - Analgesics, Non-Narcotic KW - 0 KW - Anti-Anxiety Agents KW - Plant Preparations KW - Reactive Oxygen Species KW - Acetaminophen KW - 362O9ITL9D KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - United States KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Glutathione -- metabolism KW - Humans KW - Mitochondria, Liver -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Dietary Supplements -- adverse effects KW - Oxidative Stress -- drug effects KW - Liver Failure -- chemically induced KW - Drug Synergism KW - Male KW - Hepatocytes -- drug effects KW - Plant Preparations -- chemistry KW - Analgesics, Non-Narcotic -- toxicity KW - Anti-Anxiety Agents -- toxicity KW - Plant Preparations -- toxicity KW - Kava -- chemistry KW - Acetaminophen -- toxicity KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/865189535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Phytomedicine+%3A+international+journal+of+phytotherapy+and+phytopharmacology&rft.atitle=Kava+extract%2C+an+herbal+alternative+for+anxiety+relief%2C+potentiates+acetaminophen-induced+cytotoxicity+in+rat+hepatic+cells.&rft.au=Yang%2C+Xi%3BSalminen%2C+William+F&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2011-05-15&rft.volume=18&rft.issue=7&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Phytomedicine+%3A+international+journal+of+phytotherapy+and+phytopharmacology&rft.issn=1618-095X&rft_id=info:doi/10.1016%2Fj.phymed.2011.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-09-06 N1 - Date created - 2011-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.phymed.2011.02.006 ER - TY - JOUR T1 - High performance stationary phases for planar chromatography AN - 1266748028; 14770151 AB - The kinetic performance of stabilized particle layers, particle membranes, and thin films for thin-layer chromatography is reviewed with a focus on how layer characteristics and experimental conditions affect the observed plate height. Forced flow and pressurized planar electrochromatography are identified as the best candidates to overcome the limited performance achieved by capillary flow for stabilized particle layers. For conventional and high performance plates band broadening is dominated by molecular diffusion at low mobile phase velocities typical of capillary flow systems and by mass transfer with a significant contribution from flow anisotropy at higher flow rates typical of forced flow systems. There are few possible changes to the structure of stabilized particle layers that would significantly improve their performance for capillary flow systems while for forced flow a number of avenues for further study are identified. New media for ultra thin-layer chromatography shows encouraging possibilities for miniaturized high performance systems but the realization of their true performance requires improvements in instrumentation for sample application and detection. JF - Journal of Chromatography A AU - Poole, Salwa K AU - Poole, Colin F AD - Detroit District Laboratory, US Food and Drug Administration, 300 River Place, Suite 5900, Detroit, MI 48207, USA, cfp@chem.wayne.edu Y1 - 2011/05/13/ PY - 2011 DA - 2011 May 13 SP - 2648 EP - 2660 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 19 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Thin-layer chromatography KW - Stationary phases KW - Plate height measurements KW - Theory KW - Capillary flow KW - Forced flow KW - Planar electrochromatography KW - Ultra thin-layer chromatography KW - Particle membranes KW - Flow System KW - HPLC KW - Anisotropy KW - Instrumentation KW - Chromatography KW - Chromatographic techniques KW - Molecular diffusion KW - Mass Transfer KW - Velocity KW - Thin Films KW - Flow Rates KW - Analytical Methods KW - Planning KW - Phase velocity KW - Mass transfer KW - SW 5040:Data acquisition KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266748028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=High+performance+stationary+phases+for+planar+chromatography&rft.au=Poole%2C+Salwa+K%3BPoole%2C+Colin+F&rft.aulast=Poole&rft.aufirst=Salwa&rft.date=2011-05-13&rft.volume=1218&rft.issue=19&rft.spage=2648&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.10.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - HPLC; Anisotropy; Molecular diffusion; Chromatographic techniques; Planning; Phase velocity; Mass transfer; Flow System; Flow Rates; Instrumentation; Chromatography; Analytical Methods; Mass Transfer; Velocity; Thin Films DO - http://dx.doi.org/10.1016/j.chroma.2010.10.072 ER - TY - JOUR T1 - Reasons for compliance or noncompliance with advice to test for hepatitis C via an internet-mediated blood screening service: a qualitative study AN - 883033046; 15090414 AB - Hepatitis C virus (HCV) is mainly transmitted by exposure to infected blood, and can lead to liver cirrhosis and liver cancer. Since the onset of HCV and the development of liver cirrhosis usually are asymptomatic, many HCV-infected individuals are still undiagnosed. To identify individuals infected with HCV in the general population, a low threshold, internet-mediated blood testing service was set up. We performed a qualitative study examining reasons for compliance and noncompliance with advice to test for HCV via the online blood testing service. Semistructured telephone interviews were conducted with 33 website visitors who had been advised to test for HCV (18 testers, 15 non-testers). Transcribed interviews were analyzed qualitatively and interpreted using psychosocial theories of health behavior. Reasons for testing pertaining to the online service were: the testing procedure is autonomous, personalized test advice is provided online, reminder emails are sent, and there is an online planning tool. Reasons for testing not specific to the online service were: knowing one's status can prevent liver disease and further transmission of HCV, HCV is curable, testing can provide reassurance, physical complaints are present, and there is liver disease in one's social environment. Service-related reasons for not testing pertained to inconvenient testing facilities, a lack of commitment due to the low threshold character of the service, computer/printing problems, and incorrectly interpreting an online planning tool. The reasons for not testing that are not specific to the online service were: the belief that personal risk is low, the absence of symptoms, low perceived urgency for testing and treatment, fear of the consequences of a positive test result, avoiding threatening information, and a discouraging social environment. Features specific to the online service played a significant role in motivation to test for HCV above and beyond the more conventional perceived health benefits of HCV testing. However, some online specific features were considered problematic and need to be adapted. Methods and strategies for dealing with these impeding factors and for improving compliance with testing via the online service are outlined. JF - BMC Public Health AU - Zuure, Freke R AU - Heijman, Titia AU - Urbanus, Anouk T AU - Prins, Maria AU - Kok, Gerjo AU - Davidovich, Udi AD - Cluster Infectious Diseases, Department of Research, Public Health Service of Amsterdam, Amsterdam, the Netherlands Y1 - 2011/05/10/ PY - 2011 DA - 2011 May 10 SP - 293 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Blood KW - Cancer KW - Cirrhosis KW - Compliance KW - Computers KW - Disease transmission KW - Fear KW - Hepatitis KW - Hepatitis C KW - Internet KW - Liver KW - Liver cancer KW - Liver diseases KW - Motivation KW - Perception KW - Printing KW - Public health KW - Reminder KW - Risk factors KW - Social environment KW - Hepatitis C virus KW - V 22400:Human Diseases KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883033046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Public+Health&rft.atitle=Reasons+for+compliance+or+noncompliance+with+advice+to+test+for+hepatitis+C+via+an+internet-mediated+blood+screening+service%3A+a+qualitative+study&rft.au=Zuure%2C+Freke+R%3BHeijman%2C+Titia%3BUrbanus%2C+Anouk+T%3BPrins%2C+Maria%3BKok%2C+Gerjo%3BDavidovich%2C+Udi&rft.aulast=Zuure&rft.aufirst=Freke&rft.date=2011-05-10&rft.volume=11&rft.issue=&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=BMC+Public+Health&rft.issn=1471-2458&rft_id=info:doi/10.1186%2F1471-2458-11-293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Printing; Liver diseases; Cirrhosis; Motivation; Fear; Computers; Liver cancer; Public health; Disease transmission; Blood; Risk factors; Reminder; Social environment; Hepatitis C; Internet; Hepatitis; Perception; Compliance; Liver; Cancer; Hepatitis C virus DO - http://dx.doi.org/10.1186/1471-2458-11-293 ER - TY - GEN T1 - Helping Children and Youth Who Have Experienced Traumatic Events. National Children's Mental Health Awareness Day--May 3, 2011. HHS Publication Number SMA-11-4642 AN - 964181736; ED525061 AB - Childhood exposure to traumatic events is a major public health problem in the United States. Traumatic events can include witnessing or experiencing physical or sexual abuse, violence in families and communities, loss of a loved one, refugee and war experiences, living with a family member whose caregiving ability is impaired, and having a life-threatening injury or illness. It is estimated that 26% of children in the United States will witness or experience a traumatic event before the age of 4 years. According to the Centers for Disease Control and Prevention (CDC), almost 60% of American adults say that they endured abuse or other difficult family circumstances during childhood. Research has shown that exposure to traumatic events early in life can have many negative effects throughout childhood and adolescence, and into adulthood. The Adverse Childhood Experiences (ACE) study found a strong relationship between traumatic events experienced in childhood as reported in adulthood and chronic physical illness such as heart disease, and mental health problems such as depression. The annual financial burden to society of childhood abuse and trauma is estimated to be $103 billion. This short report discusses the prevalence of exposure to traumatic events among children and youth participating in two Substance Abuse and Mental Health Services Administration initiatives, the problems that trauma can cause, and available treatments that can help children and youth recover. Y1 - 2011/05/03/ PY - 2011 DA - 2011 May 03 SP - 4 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Substance Abuse KW - Depression (Psychology) KW - Mental Health Programs KW - Mental Health KW - Adults KW - Children KW - Refugees KW - Trauma KW - Health Services KW - Public Health KW - Behavior Disorders KW - Heart Disorders KW - Mental Disorders KW - War KW - Incidence KW - Family Violence KW - Diseases KW - Sexual Abuse KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964181736?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Substance Abuse Treatment Admissions Aged 12 to 14. The TEDS Report AN - 964175780; ED525063 AB - This report uses data from the Treatment Episode Data Set (TEDS) for 2008 to provide information on the characteristics of youths aged 12 to 14 admitted to substance abuse treatment. In 2008, approximately 23,770 substance abuse treatment admissions were adolescents aged 12 to 14. The two most frequently reported primary substances of abuse among these admissions were marijuana (63.0 percent) and alcohol (20.8 percent). Nearly one half (45.5 percent) of admissions aged 12 to 14 reported multiple substances of abuse at admission, and almost one quarter (24.7 percent) had a psychiatric disorder in addition to their substance use problem. Nearly one fifth (17.3 percent) had been admitted to treatment at least once prior to their current admission. (Contains 6 figures and 6 endnotes.) Y1 - 2011/05/03/ PY - 2011 DA - 2011 May 03 SP - 6 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Drinking KW - Substance Abuse KW - Age Groups KW - Early Adolescents KW - Intervention KW - Marijuana KW - Outcomes of Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964175780?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Mortality associated with illegal drug use among adults in the United States AN - 925741756; 201205075 AB - Objectives: To examine all-cause and cause-specific mortality over a 15-year follow-up period in relation to at-baseline reported lifetime use of illegal drugs from five classes (marijuana, cocaine, heroin, hallucinogens, and inhalants) among adults in the United States (US) household population. Methods: The study involved 20,983 sample adults who responded to the 1991 National Health Interview Survey Drug and Alcohol Use supplemental questionnaire and also met the eligibility criteria for mortality follow-up. Cox proportional hazards models were estimated to examine the relationships. Results: Adults who at baseline reported lifetime heroin use were at significantly higher risk of all-cause death over the follow-up period (hazard rate ratio or HR=2.02; 95% confidence interval or CI 1.26 3.23), compared with those who did not report using drugs from any of the five classes, even after adjusting for age, sex, race, education, marital status, cigarette smoking status, and alcohol use status. Those who at baseline reported lifetime cocaine (no heroin) use had a significantly higher rate of death associated with human immunodeficiency virus diseases over the follow-up period than nonusers of drugs from any of the five classes. Several limitations of the analysis are discussed. Conclusions: Further research is needed to understand and track the elevated mortality associated with illegal drug use and the correlates of drug-poisoning deaths. Adapted from the source document. JF - The American Journal of Drug and Alcohol Abuse AU - Muhuri, Pradip K AU - Gfroerer, Joseph C AD - Center for Behavioral Health Statistics and Quality, Substance Abuse & Mental Health Services Administration, Maryland, USA pradip.muhuri@samhsa.hhs.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 155 EP - 164 PB - Taylor & Francis Inc., Philadelphia, PA VL - 37 IS - 3 SN - 0095-2990, 0095-2990 KW - health interview survey, death index, illegal drug use, all-cause and cause-specific mortality KW - Hazards KW - Mortality KW - Death KW - Heroin KW - Cocaine KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925741756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.atitle=Mortality+associated+with+illegal+drug+use+among+adults+in+the+United+States&rft.au=Muhuri%2C+Pradip+K%3BGfroerer%2C+Joseph+C&rft.aulast=Muhuri&rft.aufirst=Pradip&rft.date=2011-05-01&rft.volume=37&rft.issue=3&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Drug+and+Alcohol+Abuse&rft.issn=00952990&rft_id=info:doi/10.3109%2F00952990.2011.553977 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AJDABD N1 - SubjectsTermNotLitGenreText - Mortality; Substance abuse; Heroin; Death; Cocaine; Hazards DO - http://dx.doi.org/10.3109/00952990.2011.553977 ER - TY - JOUR T1 - In Vitro and In Vivo Studies of Monoclonal Antibodies with Prominent Bactericidal Activity against Burkholderia pseudomallei and Burkholderia mallei AN - 911155640; 16062998 AB - Our laboratory has developed more than a hundred mouse monoclonal antibodies (MAbs) against Burkholderia pseudomallei and Burkholderia mallei. These antibodies have been categorized into different groups based on their specificities and the biochemical natures of their target antigens. The current study first examined the bactericidal activities of a number of these MAbs by an in vitro opsonic assay. Then, the in vivo protective efficacy of selected MAbs was evaluated using BALB/c mice challenged intranasally with a lethal dose of the bacteria. The opsonic assay using dimethyl sulfoxide-treated human HL-60 cells as phagocytes revealed that 19 out of 47 tested MAbs (40%) have prominent bactericidal activities against B. pseudomallei and/or B. mallei. Interestingly, all MAbs with strong opsonic activities are those with specificity against either the capsular polysaccharides (PS) or the lipopolysaccharides (LPS) of the bacteria. On the other hand, none of the MAbs reacting to bacterial proteins or glycoproteins showed prominent bactericidal activity. Further study revealed that the antigenic epitopes on either the capsular PS or LPS molecules were readily available for binding in intact bacteria, while the epitopes on proteins/glycoproteins were less accessible to the MAbs. Our in vivo study showed that four MAbs reactive to either the capsular PS or LPS were highly effective in protecting mice against lethal bacterial challenge. The result is compatible with that of our in vitro study. The MAbs with the highest protective efficacy are those reactive to either the capsular PS or LPS of the Burkholderia bacteria. JF - Clinical and Vaccine Immunology AU - Zhang, Shaw-Huey Feng Bingjie Li Shimin AU - Kim, Joe Rodriguez Shien Tsaiand Shyh-Ching Lo Hyung-Yong AD - Department of Environmental and Infectious Disease Sciences, American Registry of Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, shyhching.lo@fda.hhs.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 825 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 18 IS - 5 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Burkholderia pseudomallei KW - Bacteria KW - Monoclonal antibodies KW - Phagocytes KW - Burkholderia mallei KW - Lipopolysaccharides KW - Glycoproteins KW - Bactericidal activity KW - Capsular polysaccharides KW - Epitopes KW - Lethal dose KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=In+Vitro+and+In+Vivo+Studies+of+Monoclonal+Antibodies+with+Prominent+Bactericidal+Activity+against+Burkholderia+pseudomallei+and+Burkholderia+mallei&rft.au=Zhang%2C+Shaw-Huey+Feng+Bingjie+Li+Shimin%3BKim%2C+Joe+Rodriguez+Shien+Tsaiand+Shyh-Ching+Lo+Hyung-Yong&rft.aulast=Zhang&rft.aufirst=Shaw-Huey+Feng+Bingjie+Li&rft.date=2011-05-01&rft.volume=18&rft.issue=5&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00533-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Phagocytes; Monoclonal antibodies; Lipopolysaccharides; Glycoproteins; Capsular polysaccharides; Bactericidal activity; Epitopes; Lethal dose; Burkholderia pseudomallei; Bacteria; Burkholderia mallei DO - http://dx.doi.org/10.1128/CVI.00533-10 ER - TY - JOUR T1 - Harm reduction intensity-Its role in HAART adherence amongst drug users in Amsterdam AN - 896181898; 201117347 AB - Background Opioid substitution treatment seems to improve adherence to highly active antiretroviral therapy (HAART) in drug users (DU). DU in Amsterdam receive methadone within a harm reduction programme. We hypothesized that not only receiving methadone, but joining this complete comprehensive programme would improve HAART adherence. Methods Included were 102 HIV-positive DU attending the Amsterdam Cohort Study (ACS), reporting HAART use at multiple visits between 1999 and 2009. Non-adherence was defined as taking less than 95% of medication in the past 6 months (self-reported). Harm reduction intensity (HR) was measured by combining injecting drug use, methadone dosage and needle exchange, in different levels of participation, ranging from no/incomplete HR, complete HR to low or no dependence on HR. We studied the association between non-adherence and harm reduction intensities with logistic regression models adjusted for repeated measurements. Results Non-adherence was reported in 11.9% of ACS visits. Non-injecting DU with low dependence on HR were less adherent than DU with complete HR (aOR 1.78; CI 95% 1.003.16), although there was no overall effect of HR. No difference was demonstrated in adherence between DU with complete HR and incomplete HR. Unsupervised housing (no access to structural support at home) (aOR 2.58; CI 95% 1.404.73) and having a steady partner (aOR 0.48; CI 95% 0.240.96) were significantly associated with respectively more and less non-adherence. Conclusions In Amsterdam, still-injecting DU who are exposed to systematic and integrated care, although not practising complete harm reduction, can be just as adherent to HAART as DU who make use of complete harm reduction and non-injecting DU with no dependence on harm reduction. These findings suggest the importance of a systematic and comprehensive support system including supervised housing and social and medical support to increase HAART adherence rates amongst all HIV-infected DU. When such programmes are introduced in settings where injecting drug use is highly prevalent, access to HAART for drug users in these settings can and should be increased. [Copyright Elsevier B.V.] JF - International Journal of Drug Policy AU - Lambers, Femke A.E. AU - Stolte, Ineke G AU - van den Berg, Charlotte H.S.B. AU - Coutinho, Roel A AU - Prins, Maria AD - Public Health Service Amsterdam, Department of Research, Cluster Infectious Diseases, Nieuwe Achtergracht 100, 1018 WT Amsterdam, The Netherlands flambers@ggd.amsterdam.nl Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 210 EP - 218 PB - Elsevier, Amsterdam The Netherlands VL - 22 IS - 3 SN - 0955-3959, 0955-3959 KW - HAART Adherence Harm reduction Drug users KW - Methadone KW - Housing KW - Adherence KW - Drug addicts KW - Antiretroviral therapy KW - Harm reduction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896181898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Drug+Policy&rft.atitle=Harm+reduction+intensity-Its+role+in+HAART+adherence+amongst+drug+users+in+Amsterdam&rft.au=Lambers%2C+Femke+A.E.%3BStolte%2C+Ineke+G%3Bvan+den+Berg%2C+Charlotte+H.S.B.%3BCoutinho%2C+Roel+A%3BPrins%2C+Maria&rft.aulast=Lambers&rft.aufirst=Femke&rft.date=2011-05-01&rft.volume=22&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Drug+Policy&rft.issn=09553959&rft_id=info:doi/10.1016%2Fj.drugpo.2011.02.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adherence; Antiretroviral therapy; Harm reduction; Methadone; Drug addicts; Housing DO - http://dx.doi.org/10.1016/j.drugpo.2011.02.004 ER - TY - JOUR T1 - The Office of Health Assessment and Translation: A Problem-Solving Resource for the National Toxicology Program AN - 885054323; 15090561 JF - Environmental Health Perspectives AU - Bucher, John R AU - Thayer, Kristina AU - Birnbaum, Linda S AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, bucher@niehs.nih.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - A196 EP - A197 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 5 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Environment Abstracts KW - Toxicology KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885054323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=The+Office+of+Health+Assessment+and+Translation%3A+A+Problem-Solving+Resource+for+the+National+Toxicology+Program&rft.au=Bucher%2C+John+R%3BThayer%2C+Kristina%3BBirnbaum%2C+Linda+S&rft.aulast=Bucher&rft.aufirst=John&rft.date=2011-05-01&rft.volume=119&rft.issue=5&rft.spage=A196&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103645 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Toxicology DO - http://dx.doi.org/10.1289/ehp.1103645 ER - TY - JOUR T1 - Coal mine methane; a review of capture and utilization practices with benefits to mining safety and to greenhouse gas reduction AN - 881450400; 2011-062639 AB - Coal mine methane (CMM) is a term given to the methane gas produced or emitted in association with coal mining activities either from the coal seam itself or from other gassy formations underground. The amount of CMM generated at a specific operation depends on the productivity of the coal mine, the gassiness of the coal seam and any underlying and overlying formations, operational variables, and geological conditions. CMM can be captured by engineered boreholes that augment the mine's ventilation system or it can be emitted into the mine environment and exhausted from the mine shafts along with ventilation air. The large amounts of methane released during mining present concerns about adequate mine ventilation to ensure worker safety, but they also can create opportunities to generate energy if this gas is captured and utilized properly. This article reviews the technical aspects of CMM capture in and from coal mines, the main factors affecting CMM accumulations in underground coal mines, methods for capturing methane using boreholes, specific borehole designs for effective methane capture, aspects of removing methane from abandoned mines and from sealed/active gobs of operating mines, benefits of capturing and controlling CMM for mine safety, and benefits for energy production and greenhouse gas (GHG) reduction. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Ruiz, Felicia A AU - Cote, M AU - Phipps, Sally Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 121 EP - 156 PB - Elsevier, Amsterdam VL - 86 IS - 2-3 SN - 0166-5162, 0166-5162 KW - United States KW - best management practices KW - mining KW - mines KW - technology KW - Far East KW - degasification KW - underground mining KW - natural gas KW - coal mines KW - petroleum KW - India KW - carbon dioxide KW - ventilation KW - utilization KW - safety KW - longwall mining KW - boreholes KW - Indian Peninsula KW - coalbed methane KW - greenhouse gases KW - Asia KW - China KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881450400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Coal+mine+methane%3B+a+review+of+capture+and+utilization+practices+with+benefits+to+mining+safety+and+to+greenhouse+gas+reduction&rft.au=Karacan%2C+C+Ozgen%3BRuiz%2C+Felicia+A%3BCote%2C+M%3BPhipps%2C+Sally&rft.aulast=Karacan&rft.aufirst=C&rft.date=2011-05-01&rft.volume=86&rft.issue=2-3&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.02.009 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 127 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; best management practices; boreholes; carbon dioxide; China; coal mines; coalbed methane; degasification; Far East; greenhouse gases; India; Indian Peninsula; longwall mining; mines; mining; natural gas; petroleum; safety; technology; underground mining; United States; utilization; ventilation DO - http://dx.doi.org/10.1016/j.coal.2011.02.009 ER - TY - RPRT T1 - Table of contents AN - 878891982 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-05-01&rft.volume=&rft.issue=565&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878891981 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-05-01&rft.volume=&rft.issue=565&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF MILK THISTLE EXTRACT (CAS NO. 84604-20-6) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) AN - 878891902; 21685957 AB - Milk thistle extracts have been used in herbal medicine for the treatment of liver cirrhosis, chronic hepatitis, and gallbladder disorders, in addition to a variety of other ailments. We studied the effects of milk thistle extract given to rats and mice in the feed to identify potential toxic or cancer-related hazards. We gave feed containing 12,500, 25,000, or 50,000 parts per million (1.25%, 2.5%, or 5%) of milk thistle extract to groups of 50 male and female rats and mice for two years. Similar groups of animals were given feed with no chemical added and served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival of all exposed groups of animals was similar to their controls. The body weights of male and female mice given milk thistle extract were less than for the control animals. There were no increases in the incidences of cancers at any sites, and the rates of mammary gland cancers in female rats and liver cancers in male mice were lower in animals given milk thistle extract than in their control groups. We conclude that milk thistle extract did not cause cancer in male or female rats or mice. The incidences of mammary gland cancers in female rats and liver cancers in male mice were lower than the background rate in animals receiving milk thistle extract. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1 EP - 177 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Mutagens KW - Plant Extracts KW - Herbal medicine KW - Flowers & plants KW - Toxicology KW - Rodents KW - Animals KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Genitalia -- pathology KW - Mutagens -- toxicity KW - Mice KW - Estrous Cycle -- drug effects KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Plant Extracts -- toxicity KW - Diet KW - Cell Transformation, Neoplastic KW - Female KW - Male KW - Organ Size -- drug effects KW - Carcinogens -- toxicity KW - Milk Thistle -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+MILK+THISTLE+EXTRACT+%28CAS+NO.+84604-20-6%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-05-01&rft.volume=&rft.issue=565&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program May 2011 N1 - Document feature - Photographs; Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Discomfort Glare Comparison for Various LED Cap Lamps AN - 876236472; 15010236 AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) are investigating different lighting technologies with the objective of improving mine safety. This paper presents the results from an ongoing study that compares discomfort glare for different light-emitting diode (LED) cap lamps using the de Boer glare rating scale. The cap lamps tested included two commercially-available LED cap lamps and one NIOSH prototype LED cap lamp tested at three different illumination levels. Prior research indicated that the NIOSH prototype enabled much better visual performance as compared to other LED cap lamps. It uses three LEDs that produce multiple illumination areas in comparison to commercially-available cap lamps that use one LED and projects a narrow spot pattern. Across subjects and cap lamp test conditions, measured illuminances (averaged at both eyes) varied from 0.62 to 3.73 lx, whereas the de Boer glare ratings varied from 4.86 to 7.71. An analysis of variance based on 15 subjects indicated a significant difference in the discomfort glare due to cap lamps ( F 4 , 52 = 18.01 , p < 0.001 ). Post hoc tests indicate that one of the commercially available cap lamps exhibited lower discomfort scores, with no statistically significant differences detected between the others. Thus, the NIOSH prototype cap lamp does not cause excessive discomfort glare yet enables better visual performance. JF - IEEE Transactions on Industry Applications AU - Sammarco, John J AU - Mayton, Alan G AU - Lutz, Timothy AU - Gallagher, Sean AD - National Institute for Occupational Safety and Health, Pittsburgh, PA , USA Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 1168 EP - 1174 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 47 IS - 3 SN - 0093-9994, 0093-9994 KW - Health & Safety Science Abstracts KW - prototypes KW - Occupational safety KW - Lighting KW - Mines KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876236472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Industry+Applications&rft.atitle=Discomfort+Glare+Comparison+for+Various+LED+Cap+Lamps&rft.au=Sammarco%2C+John+J%3BMayton%2C+Alan+G%3BLutz%2C+Timothy%3BGallagher%2C+Sean&rft.aulast=Sammarco&rft.aufirst=John&rft.date=2011-05-01&rft.volume=47&rft.issue=3&rft.spage=1168&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Industry+Applications&rft.issn=00939994&rft_id=info:doi/10.1109%2FTIA.2011.2126016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - prototypes; Occupational safety; Lighting; Mines; Technology DO - http://dx.doi.org/10.1109/TIA.2011.2126016 ER - TY - JOUR T1 - Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment AN - 874189331; 14972738 AB - Recent advances in field of cancer research have established that all major human cancers, in addition to having a large number of genetic alterations, exhibit prominent epigenetic abnormalities that can be used as biomarkers for the molecular diagnosis of cancer. Currently, epigenetic markers have shown promise in establishing the diagnosis and prognosis of all major human cancers. Additionally, accumulating evidence suggests that epigenetic alterations may be early indicators of genotoxic and non-genotoxic carcinogenic exposure and may be used as biomarkers in the assessment of the carcinogenic potential of environmental chemical and physical agents. This review presents current evidence on the role of epigenetic alterations in chemical carcinogenesis and highlights a number of advantages of epigenetic biomarkers over traditionally used methods in cancer risk assessment. JF - Toxicology Mechanisms and Methods AU - Koturbash, I AU - Beland, F A AU - Pogribny, I P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA, igor.pogribny@fda.hhs.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 289 EP - 297 VL - 21 IS - 4 SN - 1537-6516, 1537-6516 KW - Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Risk Abstracts; Environment Abstracts; Toxicology Abstracts KW - Bioindicators KW - epigenetics KW - Cancer KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health KW - N 14825:Gene Regulation KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874189331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Role+of+epigenetic+events+in+chemical+carcinogenesis--a+justification+for+incorporating+epigenetic+evaluations+in+cancer+risk+assessment&rft.au=Koturbash%2C+I%3BBeland%2C+F+A%3BPogribny%2C+I+P&rft.aulast=Koturbash&rft.aufirst=I&rft.date=2011-05-01&rft.volume=21&rft.issue=4&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2011.557881 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-04-03 N1 - SubjectsTermNotLitGenreText - epigenetics; Cancer DO - http://dx.doi.org/10.3109/15376516.2011.557881 ER - TY - JOUR T1 - From Waddington's epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research AN - 874189323; 14972736 AB - The term epigenetics was coined in 1942 by C.H. Waddington in the context of studies on development. Since then, the meaning of epigenetics changed over time. In the beginning, epigenetics was viewed as a phenomenon above and beyond genetics. Epigenetic explanations were invoked when genetics could not explain a phenomenon. From the mid-seventies, the state of understanding started changing. Epigenetics has now morphed from a phenomenon to a branch of science whose molecular underpinnings are well understood. The current state of knowledge of epigenetics has evolved as our understanding of DNA methylation, chromatin modifications, and noncoding RNA, and their effects on gene expression increased. At this time in the annals of epigentics research, it is appropriate to revisit some of the important discoveries that have helped advance the field to its current state. This is a very brief review of some early discoveries, and by no means is a complete account of the history of epigenetics. In this review, the early history has also been emphasized in order to underscore the transformation of the science of epigenetics from a phenomenon to a modern field of intense research. JF - Toxicology Mechanisms and Methods AU - Choudhuri, S AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, OFAS/DBGNR, HFS- 255, 5100 Paint Branch Parkway, College Park, MD 20740, USA, Supratim.Choudhuri@fda.hhs.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 252 EP - 274 VL - 21 IS - 4 SN - 1537-6516, 1537-6516 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Gene expression KW - Transformation KW - RNA KW - Chromatin KW - epigenetics KW - Reviews KW - Landscape KW - DNA methylation KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874189323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=From+Waddington%27s+epigenetic+landscape+to+small+noncoding+RNA%3A+some+important+milestones+in+the+history+of+epigenetics+research&rft.au=Choudhuri%2C+S&rft.aulast=Choudhuri&rft.aufirst=S&rft.date=2011-05-01&rft.volume=21&rft.issue=4&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2011.559695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Transformation; Gene expression; Chromatin; RNA; epigenetics; Reviews; Landscape; DNA methylation DO - http://dx.doi.org/10.3109/15376516.2011.559695 ER - TY - JOUR T1 - O serogroup specific real time PCR assays for the detection and identification of nine clinically relevant non-O157 STECs AN - 869805977; 14522776 AB - TaqMan(TM) real time PCR assays were designed for each of the non-O157 STEC O serogroups most commonly associated with human illness: O26, O45, O91, O103, O111, O113, O121, O128, and O145. The nine RT-PCR assays can be run as single assays when a known pathogen is of concern, or multiplexed in three reactions, to quickly screen for the most clinically relevant O serogroups. All assays included an internal amplification control constructed from the green fluorescent protein gene as an indicator of PCR inhibition. Of 103 strains tested, the inclusive tests accurately identified the O serogroup for 101 strains. The exclusive tests for each assay yielded no false positives for over 120 Escherichia coli strains and 23 non-E. coli bacteria tested. Furthermore, the RT-PCR assays were tested by inoculating four food matrices, milk, apple juice, lettuce, and ground beef, at less than or equal to 30CFU/25g or mL. Following a 24h selective enrichment, the RT-PCR assays detected STECs in all foods except for one ground beef sample inoculated with O111, and all apple juice samples inoculated with O113. The assays could also detect each O serogroup in human stool specimens inoculated with STECs at 1000CFU/0.5g of stool following 24h enrichment. JF - Food Microbiology AU - Lin, Andrew AU - Sultan, Omar AU - Lau, Henry K AU - Wong, Evelyn AU - Hartman, Gary AU - Lauzon, Carol R AD - U.S. Food and Drug Administration, San Francisco District Laboratory, 1431 Harbor Bay Parkway, Alameda, CA 94502, United States Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 478 EP - 483 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 3 SN - 0740-0020, 0740-0020 KW - Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Shiga toxin KW - Foodborne disease KW - Escherichia coli surveillance KW - Milk KW - Food KW - Green fluorescent protein KW - Assays KW - Pathogens KW - Fruit juices KW - Beef KW - Escherichia coli KW - Malus KW - Proteins KW - Polymerase chain reaction KW - Feces KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869805977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=O+serogroup+specific+real+time+PCR+assays+for+the+detection+and+identification+of+nine+clinically+relevant+non-O157+STECs&rft.au=Lin%2C+Andrew%3BSultan%2C+Omar%3BLau%2C+Henry+K%3BWong%2C+Evelyn%3BHartman%2C+Gary%3BLauzon%2C+Carol+R&rft.aulast=Lin&rft.aufirst=Andrew&rft.date=2011-05-01&rft.volume=28&rft.issue=3&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2010.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fruit juices; Milk; Beef; Food; Green fluorescent protein; Polymerase chain reaction; Pathogens; Feces; Assays; Proteins; Escherichia coli; Malus DO - http://dx.doi.org/10.1016/j.fm.2010.10.007 ER - TY - JOUR T1 - Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats. AN - 865694112; 20924559 AB - Welding generates complex metal fumes that vary in composition. The objectives of this study were to compare the persistence of deposited metals and the inflammatory potential of stainless and mild steel welding fumes, the two most common fumes used in US industry. Sprague-Dawley rats were exposed to 40 mg/m(3) of stainless or mild steel welding fumes for 3 h/day for 3 days. Controls were exposed to filtered air. Generated fume was collected, and particle size and elemental composition were determined. Bronchoalveolar lavage was done on days 0, 8, 21, and 42 after the last exposure to assess lung injury/inflammation and to recover lung phagocytes. Non-lavaged lung samples were analyzed for total and specific metal content as a measure of metal persistence. Both welding fumes were similar in particle morphology and size. Following was the chemical composition of the fumes-stainless steel: 57% Fe, 20% Cr, 14% Mn, and 9% Ni; mild steel: 83% Fe and 15% Mn. There was no effect of the mild steel fume on lung injury/inflammation at any time point compared to air control. Lung injury and inflammation were significantly elevated at 8 and 21 days after exposure to the stainless steel fume compared to control. Stainless steel fume exposure was associated with greater recovery of welding fume-laden macrophages from the lungs at all time points compared with the mild steel fume. A higher concentration of total metal was observed in the lungs of the stainless steel welding fume at all time points compared with the mild steel fume. The specific metals present in the two fumes were cleared from the lungs at different rates. The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs. JF - Archives of toxicology AU - Antonini, James M AU - Roberts, Jenny R AU - Stone, Samuel AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Chapman, Rebecca AU - Zeidler-Erdely, Patti C AU - Andrews, Ronnee N AU - Frazer, David G AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. jga6@cdc.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 487 EP - 498 VL - 85 IS - 5 KW - Air Pollutants, Occupational KW - 0 KW - Gases KW - Metals KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Models, Animal KW - Animals KW - Lung Injury -- chemically induced KW - Particle Size KW - Inflammation -- chemically induced KW - Bronchoalveolar Lavage KW - Rats KW - Rats, Sprague-Dawley KW - Phagocytosis -- drug effects KW - Lung Injury -- pathology KW - Male KW - Inflammation -- pathology KW - Macrophages -- metabolism KW - Metals -- toxicity KW - Gases -- analysis KW - Stainless Steel -- toxicity KW - Inhalation Exposure KW - Lung -- drug effects KW - Welding KW - Lung -- pathology KW - Air Pollutants, Occupational -- toxicity KW - Gases -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/865694112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Persistence+of+deposited+metals+in+the+lungs+after+stainless+steel+and+mild+steel+welding+fume+inhalation+in+rats.&rft.au=Antonini%2C+James+M%3BRoberts%2C+Jenny+R%3BStone%2C+Samuel%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BChapman%2C+Rebecca%3BZeidler-Erdely%2C+Patti+C%3BAndrews%2C+Ronnee+N%3BFrazer%2C+David+G&rft.aulast=Antonini&rft.aufirst=James&rft.date=2011-05-01&rft.volume=85&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-010-0601-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2011-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00204-010-0601-1 ER - TY - JOUR T1 - Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. AN - 864780499; 21147608 AB - 1,3-Butadiene (BD) is a high-volume industrial chemical and a known human carcinogen. The main mode of BD carcinogenicity is thought to involve formation of genotoxic epoxides. In this study we tested the hypothesis that BD may be epigenotoxic (i.e., cause changes in DNA and histone methylation) and explored the possible molecular mechanisms for the epigenetic changes. We administered BD (6.25 and 625 ppm) to C57BL/6J male mice by inhalation for 2 weeks (6 hr/day, 5 days a week) and then examined liver tissue from these mice for signs of toxicity using histopathology and gene expression analyses. We observed no changes in mice exposed to 6.25 ppm BD, but glycogen depletion and dysregulation of hepatotoxicity biomarker genes were observed in mice exposed to 625 ppm BD. We detected N-7-(2,3,4-trihydroxybut-1-yl)guanine (THB-Gua) adducts in liver DNA of exposed mice in a dose-responsive manner, and also observed extensive alterations in the cellular epigenome in the liver, including demethylation of global DNA and repetitive elements and a decrease in histone H3 and H4 lysine methylation. In addition, we observed down-regulation of DNA methyltransferase 1 (Dnmt1) and suppressor of variegation 3-9 homolog 1, a histone lysine methyltransferase (Suv39h1), and up-regulation of the histone demethylase Jumonji domain 2 (Jmjd2a), proteins responsible for the accurate maintenance of the epigenetic marks. Although the epigenetic effects were most pronounced in the 625-ppm exposure group, some effects were evident in mice exposed to 6.25 ppm BD. This study demonstrates that exposure to BD leads to epigenetic alterations in the liver, which may be important contributors to the mode of BD carcinogenicity. JF - Environmental health perspectives AU - Koturbash, Igor AU - Scherhag, Anne AU - Sorrentino, Jessica AU - Sexton, Kenneth AU - Bodnar, Wanda AU - Tryndyak, Volodymyr AU - Latendresse, John R AU - Swenberg, James A AU - Beland, Frederick A AU - Pogribny, Igor P AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 635 EP - 640 VL - 119 IS - 5 KW - Butadienes KW - 0 KW - Repressor Proteins KW - Histone Demethylases KW - EC 1.14.11.- KW - JMJD2A protein, mouse KW - Suv39h1 protein, mouse KW - EC 2.1.1. KW - Methyltransferases KW - EC 2.1.1.- KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - 1,3-butadiene KW - JSD5FGP5VD KW - Index Medicus KW - Inhalation KW - Methyltransferases -- genetics KW - Animals KW - Histone Demethylases -- genetics KW - Mice KW - Repressor Proteins -- genetics KW - DNA Damage -- drug effects KW - DNA (Cytosine-5-)-Methyltransferase -- genetics KW - Polymerase Chain Reaction KW - Blotting, Western KW - Body Weight -- drug effects KW - DNA Methylation -- drug effects KW - Mice, Inbred C57BL KW - Male KW - Epigenesis, Genetic -- genetics KW - Butadienes -- toxicity KW - Liver -- drug effects KW - Epigenesis, Genetic -- drug effects KW - Liver -- metabolism KW - Butadienes -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864780499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Epigenetic+alterations+in+liver+of+C57BL%2F6J+mice+after+short-term+inhalational+exposure+to+1%2C3-butadiene.&rft.au=Koturbash%2C+Igor%3BScherhag%2C+Anne%3BSorrentino%2C+Jessica%3BSexton%2C+Kenneth%3BBodnar%2C+Wanda%3BTryndyak%2C+Volodymyr%3BLatendresse%2C+John+R%3BSwenberg%2C+James+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P%3BRusyn%2C+Ivan&rft.aulast=Koturbash&rft.aufirst=Igor&rft.date=2011-05-01&rft.volume=119&rft.issue=5&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002910 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-24 N1 - Date created - 2011-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1984 Aug;5(8):989-92 [6744518] Mutat Res. 2008 Jul-Aug;659(1-2):158-65 [18342568] Crit Rev Toxicol. 1997 Jan;27(1):1-108 [9115622] Chem Res Toxicol. 1999 Jul;12(7):566-74 [10409395] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Cell. 2004 Nov 24;119(5):603-14 [15550243] Mutat Res. 2008 Jul 3;642(1-2):1-13 [18471836] Carcinogenesis. 1994 Apr;15(4):713-7 [8149485] Chem Res Toxicol. 2008 Aug;21(8):1586-93 [18656964] J Biol Chem. 2008 Nov 28;283(48):33168-74 [18826944] Nat Genet. 2009 Jan;41(1):125-9 [19098913] EXS. 2009;99:259-88 [19157065] J Proteome Res. 2009 Feb;8(2):1004-13 [19099420] Biochem Cell Biol. 2009 Feb;87(1):151-61 [19234531] Cancer Res. 2009 Mar 15;69(6):2479-86 [19276346] PLoS Genet. 2009 Mar;5(3):e1000435 [19325889] Blood. 2009 Jun 18;113(25):6411-8 [19211935] Curr Opin Pediatr. 2009 Apr;21(2):243-51 [19663042] IARC Monogr Eval Carcinog Risks Hum. 2008;97:3-471 [20232717] Hepatology. 2010 Jul;52(1):60-70 [20578129] Mutat Res. 2000 Jan 3;464(1):77-86 [10633179] Nature. 2000 Aug 10;406(6796):593-9 [10949293] Drug Metab Dispos. 2001 Jun;29(6):830-6 [11353751] Chem Biol Interact. 2001 Jun 1;135-136:27-42 [11397379] Cell. 2001 Nov 2;107(3):323-37 [11701123] Arch Toxicol. 2002 Jul;76(7):398-403 [12111004] Toxicol Lett. 2002 Aug 5;134(1-3):51-6 [12191860] Hepatology. 2003 Apr;37(4):810-23 [12668974] Nucleic Acids Res. 2003 May 1;31(9):2305-12 [12711675] Nucleic Acids Res. 2004;32(3):e38 [14973332] Toxicol Sci. 2004 Aug;80(2):218-24 [15141100] EMBO J. 2005 Feb 23;24(4):800-12 [15678104] Annu Rev Biochem. 2005;74:481-514 [15952895] Nat Genet. 2005 Aug;37(8):853-62 [16007088] Nature. 2006 Feb 16;439(7078):871-4 [16357870] Cell. 2006 May 5;125(3):483-95 [16603237] Toxicol Sci. 2006 Jun;91(2):393-405 [16537655] Genes Dev. 2006 Jun 15;20(12):1557-62 [16738407] Carcinogenesis. 2006 Aug;27(8):1713-20 [16632870] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):416-25 [16926038] Genes Dev. 2006 Nov 15;20(22):3089-103 [17085482] Cancer Res. 2007 Feb 1;67(3):946-50 [17283125] Nature. 2007 Feb 8;445(7128):671-5 [17268471] Chem Biol Interact. 2007 Mar 20;166(1-3):93-103 [16616907] Chem Biol Interact. 2007 Mar 20;166(1-3):10-4 [17324391] DNA Repair (Amst). 2007 Aug 1;6(8):1155-60 [17482895] Nat Struct Mol Biol. 2007 Aug;14(8):689-95 [17589523] J Cell Biol. 2007 Sep 10;178(6):925-36 [17846168] Mutat Res. 2007 Dec 1;625(1-2):62-71 [17586532] Toxicol Appl Pharmacol. 2007 Dec 15;225(3):293-9 [17920094] Environ Mol Mutagen. 2008 Jan;49(1):9-15 [17879298] Carcinogenesis. 2008 Mar;29(3):638-46 [18204080] Hum Mol Genet. 2008 May 1;17(9):1306-17 [18252747] Nat Protoc. 2008;3(6):1101-8 [18546601] Comment In: Environ Health Perspect. 2011 May;119(5):A218 [21531661] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.1002910 ER - TY - JOUR T1 - Discrimination of haptens from prohaptens using the metabolically deficient Cpr(low/low) mouse. AN - 862792978; 21376747 AB - The murine local lymph node assay (LLNA) is a validated, well accepted method for identification of chemical contact allergens. Both direct acting haptens and prohaptens (requiring metabolic activation) can be identified, but not differentiated by this assay. This study was used to assess the utility of a pan microsomal metabolic deficient mouse to distinguish between direct acting haptens and prohaptens in the LLNA. Hapten and prohapten induced cell proliferation was compared in C57BL/6J (B6) wild type (WT) versus homozygous (HO) knockout mice with a hypomorphic NADPH-Cytochrome P450 Reductase (CPR) gene (termed Cpr(low/low)) resulting in low CPR enzyme activity. Mice were dosed with known prohaptens; benzo(a)pyrene (BaP), carvone oxime (COx) and paracetamol (PCM) and haptens; oxazolone (OX), 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (EtOX), and N-acetylbenzoquinoneimine (NABQI) in this study. Skin microsomes from the WT, HO and heterozygous (HT) Cpr(low/low) mice were compared and evaluated for CPR activity. Lymphocyte proliferative responses to BaP, COx and PCM were significantly abrogated by 36.4%, 45.2% and 50.8%, respectively; in Cpr(low/low) knock out (KO) mice versus WT mice; while the lymphocyte proliferative responses to the direct acting haptens OX, EtOX and NABQI were comparable. CPR activity, determined as Units/mg protein, was determined to be significantly lower in the Cpr(low/low) mice compared to the WT. Results of the present study suggest potential utility of the Cpr(low/low) mice in the LLNA to differentiate prohaptens from direct acting haptens. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Chipinda, Itai AU - Blachere, Francoise M AU - Anderson, Stacey E AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown,WV 26505-2888, USA. IChipinda@cdc.gov Y1 - 2011/05/01/ PY - 2011 DA - 2011 May 01 SP - 268 EP - 272 VL - 252 IS - 3 KW - Allergens KW - 0 KW - Haptens KW - NADPH-Ferrihemoprotein Reductase KW - EC 1.6.2.4 KW - Index Medicus KW - Animals KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Mice KW - Local Lymph Node Assay KW - Male KW - Female KW - Mice, Knockout KW - NADPH-Ferrihemoprotein Reductase -- genetics KW - Skin -- drug effects KW - Haptens -- metabolism KW - Skin -- metabolism KW - Allergens -- metabolism KW - Haptens -- pharmacology KW - NADPH-Ferrihemoprotein Reductase -- metabolism KW - NADPH-Ferrihemoprotein Reductase -- deficiency KW - Allergens -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862792978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Discrimination+of+haptens+from+prohaptens+using+the+metabolically+deficient+Cpr%28low%2Flow%29+mouse.&rft.au=Chipinda%2C+Itai%3BBlachere%2C+Francoise+M%3BAnderson%2C+Stacey+E%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2011-05-01&rft.volume=252&rft.issue=3&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-11 N1 - Date created - 2011-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.02.018 ER - TY - JOUR T1 - Update on targeted therapies for clear cell renal cell carcinoma. AN - 862280347; 21330923 AB - The article reviews the evolution of targeted therapies for clear cell renal cell carcinoma (RCC) and recent developments in the field. The vast majority of work in kidney cancer deals with clear cell RCC, which is the most common variant of this malignancy. The identification of loss of function of the von Hippel-Lindau protein as the basis for clear cell RCC, in addition to the well designed clinical trials that have ensued, provide an outstanding model for the development of mechanism-based targeted therapy in cancer. The treatment of advanced and metastatic RCC continues to be a major challenge for uro-oncologists despite the approval of six targeted therapies over the past 5 years. This rapid growth in therapeutic options has brought much needed improvements in overall and progression-free survival, although durable complete responses are rare. However, the plurality of treatments also poses challenges in terms of selecting the best therapy for a given patient, designing trials with appropriate comparison arms and endpoints, identifying well tolerated and effective drug combinations or sequences, and determining the role of targeted therapies in the neoadjuvant and adjuvant settings. Vascular endothelial growth factor and mammalian target of rapamycin-targeted therapies continue to play a critical role in the management of advanced and metastatic RCC. Ongoing research to identify novel agents continues to build upon the work done during the elucidation of the von Hippel-Lindau/clear cell RCC pathway. It is hoped that ongoing and planned studies will enable development of therapeutic regimens that will incorporate agents with improved toxicity and better efficacy as well as defining a role for a multidisciplinary approach to the management of advanced RCC. JF - Current opinion in oncology AU - Singer, Eric A AU - Gupta, Gopal N AU - Srinivasan, Ramaprasad AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 283 EP - 289 VL - 23 IS - 3 KW - Index Medicus KW - Humans KW - Neoadjuvant Therapy KW - Quality of Life KW - Chemotherapy, Adjuvant KW - Kidney Neoplasms -- genetics KW - Kidney Neoplasms -- therapy KW - Carcinoma, Renal Cell -- therapy KW - Carcinoma, Renal Cell -- secondary KW - Carcinoma, Renal Cell -- genetics KW - Kidney Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862280347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+oncology&rft.atitle=Update+on+targeted+therapies+for+clear+cell+renal+cell+carcinoma.&rft.au=Singer%2C+Eric+A%3BGupta%2C+Gopal+N%3BSrinivasan%2C+Ramaprasad&rft.aulast=Singer&rft.aufirst=Eric&rft.date=2011-05-01&rft.volume=23&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+oncology&rft.issn=1531-703X&rft_id=info:doi/10.1097%2FCCO.0b013e32834479c0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-09 N1 - Date created - 2011-04-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2002 Jan 1;20(1):289-96 [11773181] Urol Oncol. 2011 May-Jun;29(3):237-43 [19914100] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] J Urol. 2003 Dec;170(6 Pt 1):2163-72 [14634372] Scand J Urol Nephrol. 1987;21(4):285-9 [3445125] J Urol. 1994 Nov;152(5 Pt 1):1626-31 [7523715] JAMA. 1999 May 5;281(17):1628-31 [10235157] J Clin Oncol. 2005 Jun 10;23(17):3923-31 [15897550] Cancer Cell. 2005 Sep;8(3):179-83 [16169463] J Support Oncol. 2006 Apr;4(4):191-9 [16669463] Cancer Res. 2006 Sep 1;66(17):8814-21 [16951198] J Natl Cancer Inst. 2006 Sep 20;98(18):1331-4 [16985252] N Engl J Med. 2007 Jan 11;356(2):115-24 [17215529] N Engl J Med. 2007 Jan 11;356(2):125-34 [17215530] N Engl J Med. 2007 May 31;356(22):2271-81 [17538086] Value Health. 2007 Jul-Aug;10(4):285-93 [17645683] Lancet Oncol. 2007 Nov;8(11):975-84 [17959415] J Clin Oncol. 2008 Apr 20;26(12):2034-9 [18347008] Cancer Immunol Immunother. 2008 Oct;57(10):1439-49 [18286285] BJU Int. 2008 Sep;102(6):692-6 [18410444] J Biol Chem. 2008 Dec 12;283(50):34495-9 [18945681] J Urol. 2009 Feb;181(2):518-23; discussion 523 [19100579] Urology. 2009 Feb;73(2):337-41 [18950837] Curr Opin Oncol. 2009 May;21(3):266-71 [19339887] Cancer Lett. 2009 Aug 8;280(2):145-53 [19111391] Cancer Res. 2009 Jun 1;69(11):4674-81 [19470766] J Clin Oncol. 2009 Jul 1;27(19):3225-34 [19470934] J Urol. 2009 Sep;182(3):881-6 [19616232] J Clin Oncol. 2009 Sep 1;27(25):4076-81 [19636008] J Clin Oncol. 2009 Sep 20;27(27):4462-8 [19652060] J Clin Oncol. 2009 Dec 1;27(34):5794-9 [19826129] J Clin Oncol. 2010 Feb 20;28(6):1061-8 [20100962] J Clin Oncol. 2010 May 1;28(13):2144-50 [20368553] J Clin Oncol. 2010 May 1;28(13):2137-43 [20368558] J Clin Oncol. 2010 May 1;28(13):2131-6 [20368560] Urol Int. 2010;84(4):479-84 [20299776] Clin Cancer Res. 2010 Jul 15;16(14):3628-38 [20606035] Target Oncol. 2010 Jun;5(2):131-8 [20632214] Target Oncol. 2010 Jun;5(2):119-29 [20680492] CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300 [20610543] Cancer. 2010 Sep 15;116(18):4256-65 [20549832] Eur Urol. 2009 Dec;56(6):959-71 [19748725] J Clin Oncol. 2010 Dec 1;28(34):5017-9 [20975069] J Clin Oncol. 2003 Apr 1;21(7):1214-22 [12663707] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CCO.0b013e32834479c0 ER - TY - JOUR T1 - Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia. AN - 861592144; 20691775 AB - Repeated administration of phencyclidine (PCP), an N-methyl-d-aspartate (NMDA) receptor antagonist, during development, may result in neuronal damage that leads to behavioral deficits in adulthood. The present study examined the potential neurotoxic effects of PCP exposure (10mg/kg) in rats on postnatal days (PNDs) 7, 9 and 11 and the possible underlying mechanism(s) for neurotoxicity. Brain tissue was harvested for RNA extraction and morphological assessments. RNA was collected from the frontal cortex for DNA microarray analysis and quantitative RT-PCR. Gene expression profiling was determined using Illumina Rat Ref-12 Expression BeadChips containing 22,226 probes. Based on criteria of a fold-change greater than 1.4 and a P-value less than 0.05, 19 genes including NMDAR1 (N-methyl-d-aspartate receptor) and four pro-apoptotic genes were up-regulated, and 25 genes including four anti-apoptotic genes were down-regulated, in the PCP-treated group. In addition, the schizophrenia-relevant genes, Bdnf (Brain-derived neurotrophic factor) and Bhlhb2 (basic helix-loop-helix domain containing, class B, 2), were significantly different between the PCP and the control groups. Quantitative RT-PCR confirmed the microarray results. Elevated neuronal cell death was further confirmed using Fluoro-Jade C staining. These findings support the hypothesis that neurodegeneration caused by PCP occurs, at least in part, through the up-regulation of NMDA receptors, which makes neurons possessing these receptors more vulnerable to endogenous glutamate. The changes in schizophrenia-relevant genes after repeated PCP exposure during development may provide important information concerning the validation of an animal model for this disorder. Published by Elsevier Ltd. JF - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience AU - Liu, F AU - Zou, X AU - Sadovova, N AU - Zhang, X AU - Shi, L AU - Guo, L AU - Qian, F AU - Wen, Z AU - Patterson, T A AU - Hanig, J P AU - Paule, M G AU - Slikker, W AU - Wang, C AD - Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 351 EP - 358 VL - 29 IS - 3 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Fluoresceins KW - fluoro-jade C KW - Phencyclidine KW - J1DOI7UV76 KW - Index Medicus KW - Animals KW - Fluoresceins -- metabolism KW - Brain -- drug effects KW - Principal Component Analysis KW - Disease Models, Animal KW - Nerve Degeneration -- chemically induced KW - Brain -- physiology KW - Rats KW - Gene Expression Profiling KW - Rats, Sprague-Dawley KW - Brain -- pathology KW - Nerve Degeneration -- pathology KW - Microarray Analysis KW - Molecular Sequence Data KW - Cluster Analysis KW - Gene Expression -- drug effects KW - Phencyclidine -- pharmacology KW - Schizophrenia -- chemically induced KW - Schizophrenia -- pathology KW - Schizophrenia -- genetics KW - Schizophrenia -- physiopathology KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861592144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+developmental+neuroscience+%3A+the+official+journal+of+the+International+Society+for+Developmental+Neuroscience&rft.atitle=Changes+in+gene+expression+after+phencyclidine+administration+in+developing+rats%3A+a+potential+animal+model+for+schizophrenia.&rft.au=Liu%2C+F%3BZou%2C+X%3BSadovova%2C+N%3BZhang%2C+X%3BShi%2C+L%3BGuo%2C+L%3BQian%2C+F%3BWen%2C+Z%3BPatterson%2C+T+A%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Liu&rft.aufirst=F&rft.date=2011-05-01&rft.volume=29&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=International+journal+of+developmental+neuroscience+%3A+the+official+journal+of+the+International+Society+for+Developmental+Neuroscience&rft.issn=1873-474X&rft_id=info:doi/10.1016%2Fj.ijdevneu.2010.07.234 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-20 N1 - Date created - 2011-04-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ijdevneu.2010.07.234 ER - TY - JOUR T1 - Assessment of heritable genetic effects using new genetic tools and sentinels in an era of personalized medicine. AN - 861204802; 21472782 AB - The challenge of estimating human health effects from damage to the germ line may be met in the genomic era. Understanding the genetic, as opposed to postconception developmental basis of birth defects is critical to their use in monitoring heritable genetic damage. The causes of common birth defects are analyzed here: mendelian genetic, multigenic, developmental, inherited, or combinational. Only a small fraction of these (noninherited, mendelian genetic) are likely to be informative relative to germ cell mutagenesis, and these won't be discernible against the general background of birth defects. Targeted genetic testing as part of personalized medicine could be integrated into a strategy for assessing germ cell alterations in populations. Thus, "sentinel mutations," as originally proposed by Mulvihill and Ceizel, need not be restricted to X-linked or dominant mutations or conditions visible at birth. Several new sentinels related to personalized medicine are proposed, based on health impact (likelihood of monitoring), frequency, and genetic target suitability (responsiveness to diverse mutational mechanisms). Candidates could include CYP genes (related to metabolism of xenobiotics) important in optimizing drug doses and avoiding adverse reactions. High frequency LDLR mutations (related to familial high cholesterol) predict myocardial infarction in approximately50% of individuals. The more common recessive genetic diseases (cystic fibrosis, phenylketonuria, and others) monitored in newborn screening programs could be informative given parental analysis. New opportunities for genetic analyses need to be coupled with epidemiological studies on environmental exposures. These could focus on adverse outcomes related to tobacco, the mostubiquitous and potent environmental mutagen. Published 2011 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Elespuru, Rosalie K AD - Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA. rosalie.elespuru@fda.hhs.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 253 EP - 263 VL - 52 IS - 4 KW - Mutagens KW - 0 KW - Index Medicus KW - Risk KW - Germ Cells KW - Genetic Testing -- methods KW - Genetic Predisposition to Disease -- genetics KW - Humans KW - Genetic Predisposition to Disease -- epidemiology KW - Mutation KW - Male KW - Genetic Testing -- statistics & numerical data KW - Female KW - Precision Medicine KW - Genetic Diseases, Inborn -- genetics KW - Genetic Diseases, Inborn -- epidemiology KW - Congenital Abnormalities -- epidemiology KW - Congenital Abnormalities -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861204802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Assessment+of+heritable+genetic+effects+using+new+genetic+tools+and+sentinels+in+an+era+of+personalized+medicine.&rft.au=Elespuru%2C+Rosalie+K&rft.aulast=Elespuru&rft.aufirst=Rosalie&rft.date=2011-05-01&rft.volume=52&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20637 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-22 N1 - Date created - 2011-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20637 ER - TY - JOUR T1 - Development of a real-time PCR assay with an internal amplification control for detection of Gram-negative histamine-producing bacteria in fish. AN - 854565339; 21356438 AB - Prompt detection of bacteria that contribute to scombrotoxin (histamine) fish poisoning can aid in the detection of potentially toxic fish products and prevent the occurrence of illness. We report development of the first real-time PCR method for rapid detection of Gram-negative histamine-producing bacteria (HPB) in fish. The real-time PCR assay was 100% inclusive for detecting high-histamine producing isolates and did not detect any of the low- or non-histamine producing isolates. The efficiency of the assay with/without internal amplification control ranged from 96-104% and in the presence of background flora and inhibitory matrices was 92/100% and 73-96%, respectively. This assay was used to detect HPB from naturally contaminated yellowfin tuna, bluefish, and false albacore samples. Photobacterium damselae (8), Plesiomonas shigelloides (2), Shewanella sp. (1), and Morganella morganii (1) were subsequently isolated from the real-time PCR positive fish samples. These results indicate that the real-time PCR assay developed in this study is a rapid and sensitive method for detecting high-HPB. The assay may be adapted for quantification of HPB, either directly or with an MPN-PCR method. Copyright © 2010. Published by Elsevier Ltd. JF - Food microbiology AU - Bjornsdottir-Butler, Kristin AU - Jones, Jessica L AU - Benner, Ronald AU - Burkhardt, William AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Dr., Dauphin Island, AL 36528, USA. Kristin.Butler@fda.hha.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 356 EP - 363 VL - 28 IS - 3 KW - DNA, Bacterial KW - 0 KW - DNA, Ribosomal KW - Histamine KW - 820484N8I3 KW - Histidine Decarboxylase KW - EC 4.1.1.22 KW - Index Medicus KW - Sensitivity and Specificity KW - Animals KW - Histidine Decarboxylase -- genetics KW - Food Microbiology KW - Consumer Product Safety KW - Humans KW - DNA, Bacterial -- genetics KW - DNA, Ribosomal -- genetics KW - Gene Amplification KW - Fishes -- microbiology KW - Gram-Negative Bacteria -- growth & development KW - Polymerase Chain Reaction -- methods KW - Food Contamination -- analysis KW - Histamine -- biosynthesis KW - Gram-Negative Bacteria -- metabolism KW - Seafood -- microbiology KW - Gram-Negative Bacteria -- isolation & purification KW - Histamine -- poisoning KW - Gram-Negative Bacteria -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/854565339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Development+of+a+real-time+PCR+assay+with+an+internal+amplification+control+for+detection+of+Gram-negative+histamine-producing+bacteria+in+fish.&rft.au=Bjornsdottir-Butler%2C+Kristin%3BJones%2C+Jessica+L%3BBenner%2C+Ronald%3BBurkhardt%2C+William&rft.aulast=Bjornsdottir-Butler&rft.aufirst=Kristin&rft.date=2011-05-01&rft.volume=28&rft.issue=3&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=1095-9998&rft_id=info:doi/10.1016%2Fj.fm.2010.06.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-11 N1 - Date created - 2011-03-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fm.2010.06.013 ER - TY - JOUR T1 - Microarray hybridization for assessment of the genetic stability of chimeric west nile/dengue 4 virus AN - 1560121337; 20635893 AB - Genetic stability is an important characteristic of live viral vaccines because an accumulation of mutants can cause reversion to a virulent phenotype as well as a loss of immunogenic properties. This study was aimed at evaluating the genetic stability of a live attenuated West Nile (WN) virus vaccine candidate that was generated by replacing the pre-membrane and envelope protein genes of dengue 4 virus with those from WN. Chimeric virus was serially propagated in Vero, SH-SY5Y human neuroblastoma and HeLa cells and screened for point mutations using hybridization with microarrays of overlapping oligonucleotide probes covering the entire genome. The analysis revealed several spontaneous mutations that led to amino acid changes, most of which were located in the envelope (E) and non-structural NS4A, NS4B, and NS5 proteins. Viruses passaged in Vero and SH-SY5Y cells shared two common mutations: G sub(2337)C (Met sub(457)Ile) in the E gene and A sub(6751)G (Lys sub(125)Arg) in the NS4A gene. Quantitative assessment of the contents of these mutants in viral stocks indicated that they accumulated independently with different kinetics during propagation in cell cultures. Mutant viruses grew better in Vero cells compared to the parental virus, suggesting that they have a higher fitness. When tested in newborn mice, the cell culture-passaged viruses did not exhibit increased neurovirulence. The approach described in this article could be useful for monitoring the molecular consistency and quality control of vaccine strains. J. Med. Virol. 83:910-920, 2011. copyright 2011 Wiley-Liss, Inc. JF - Journal of Medical Virology AU - Laassri, Majid AU - Bidzhieva, Bella AU - Speicher, James AU - Pletnev, Alexander G AU - Chumakov, Konstantin AD - Laboratory of Method Development, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland. Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 910 EP - 920 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 83 IS - 5 SN - 0146-6615, 0146-6615 KW - Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Fitness KW - Genomes KW - Virology KW - DNA probes KW - Viruses KW - Disease control KW - Reversion KW - Cell culture KW - Oligonucleotides KW - Phenotypes KW - Hybridization KW - Mutants KW - Dengue KW - Envelope protein KW - Amino acids KW - Vero cells KW - Mutations KW - Point mutation KW - Neurovirulence KW - Mice KW - Immunogenicity KW - Kinetics KW - Quality control KW - NS5 protein KW - Proteins KW - Neonates KW - Vaccines KW - Mutation KW - Amino acid sequence KW - V 22350:Immunology KW - Q1 08604:Stock assessment and management KW - G 07730:Development & Cell Cycle KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560121337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Virology&rft.atitle=Microarray+hybridization+for+assessment+of+the+genetic+stability+of+chimeric+west+nile%2Fdengue+4+virus&rft.au=Laassri%2C+Majid%3BBidzhieva%2C+Bella%3BSpeicher%2C+James%3BPletnev%2C+Alexander+G%3BChumakov%2C+Konstantin&rft.aulast=Laassri&rft.aufirst=Majid&rft.date=2011-05-01&rft.volume=83&rft.issue=5&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Virology&rft.issn=01466615&rft_id=info:doi/10.1002%2Fjmv.22033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Virology; Genomes; Mutations; Viruses; Disease control; Cell culture; Vaccines; Phenotypes; Hybridization; Fitness; Vero cells; DNA probes; Point mutation; Neurovirulence; Reversion; Oligonucleotides; Immunogenicity; Quality control; Kinetics; Envelope protein; NS5 protein; Neonates; Amino acid sequence; Amino acids; Dengue; Proteins; Mice; Mutation; Mutants DO - http://dx.doi.org/10.1002/jmv.22033 ER - TY - JOUR T1 - Metabolic Syndrome and Carotid Intima Media Thickness in Urban Police Officers AN - 1020843996; 14930902 AB - Objective: To examine the association between metabolic syndrome (MetSyn) and carotid intima media thickness (IMT) separately in male and female police officers. Methods: MetSyn was defined using 2005 guidelines. B-mode ultrasound was used to measure mean and maximum (12 and 36 segments) carotid artery thickness. Analysis of covariance was used to compare mean IMT values across individuals categorized by number of MetSyn components. Adjustments were made for age, smoking status, and low-density lipoprotein cholesterol. Results: Among 106 women, the adjusted mean common and maximum36 carotid IMT were significantly and positively associated with number of MetSyn components. No associations were found in men (n = 304). Adjusted carotid IMT values were inversely associated with low high-density lipoprotein cholesterol and directly with hypertension in women. Conclusions: Number of MetSyn components was significantly associated with carotid IMT in female but not in male officers. JF - Journal of Occupational and Environmental Medicine AU - Hartley, T A AU - Shankar, A AU - Fekedulegn, D AU - Violanti, J M AU - Andrew, ME AU - Knox, S S AU - Burchfiel, C M AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS 4050, Morgantown, WV 26505, USA, thartley@cdc.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 553 EP - 561 VL - 53 IS - 5 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Age KW - Guidelines KW - Hypertension KW - Smoking KW - cholesterol KW - metabolic disorders KW - police KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020843996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Metabolic+Syndrome+and+Carotid+Intima+Media+Thickness+in+Urban+Police+Officers&rft.au=Hartley%2C+T+A%3BShankar%2C+A%3BFekedulegn%2C+D%3BViolanti%2C+J+M%3BAndrew%2C+ME%3BKnox%2C+S+S%3BBurchfiel%2C+C+M&rft.aulast=Hartley&rft.aufirst=T&rft.date=2011-05-01&rft.volume=53&rft.issue=5&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3182171995 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Smoking; Age; metabolic disorders; police; Guidelines; cholesterol; Hypertension DO - http://dx.doi.org/10.1097/JOM.0b013e3182171995 ER - TY - JOUR T1 - Does social media improve communication? Evaluating the NIOSH science blog AN - 1017966967; 16691562 AB - Background In 2007, NIOSH created the Science Blog as its first social media channel. The blog has more than 22,000 subscribers. The purpose of the evaluation was to identify the blog community of readers, its use as a two-way conversation channel and its effectiveness as an information resource. Methods Seventy-five readers randomly participated in an online survey from July 2009 to September 2009 to evaluate the Science Blog. Results Responses indicated that the NIOSH Science Blog was a valued social media resource. Sixty percent of participants planned to continue using the blog in the next 6 months. A significant proportion of readers reported that they would make changes in the workplace based on information obtained from the Science Blog. Conclusions The NIOSH Science Blog provides is a useful communication channel to provide workplace safety and health information and expand the Institute's reach to new consumers. Am. J. Ind. Med. 54:384-394, 2011. ? 2011 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Sublet, Virginia AU - Spring, Christina AU - Howard, John AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Atlanta, Georgia, vxs3@cdc.gov Y1 - 2011/05// PY - 2011 DA - May 2011 SP - 384 EP - 394 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 5 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Communications KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Attachment+research+and+psychoanalytic+theory&rft.au=Eagle%2C+Morris+N.&rft.aulast=Eagle&rft.aufirst=Morris&rft.date=1996-01-01&rft.volume=&rft.issue=&rft.spage=105&rft.isbn=1-55798-385-2&rft.btitle=Psychoanalytic+perspectives+on+developmental+psychology&rft.title=Psychoanalytic+perspectives+on+developmental+psychology&rft.issn=&rft_id=info:doi/10.1037%2F10219-004 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20921/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Communications DO - http://dx.doi.org/10.1002/ajim.20921 ER - TY - GEN T1 - Spotlight On: Mr. Alfan Dangin AN - 875623610 AB - Alfan Dangin, a member of CVM's Communications Staff, won the 2011 Blue Pencil Award from the National Association of Government Communicators. Nominated under the special purpose category, Dangin's children's story, Sweets are Not Good Treats, received a perfect score in each category considered by the judges. Dangin has served the federal government for over twenty years. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Awards & honors KW - Veterinarians KW - Federal government KW - Dangin, Alfan KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Spotlight+On%3A+Mr.+Alfan+Dangin&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - People - Dangin, Alfan N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - Conditional Approval of Animal Drugs - What Does This Mean for Veterinarians? AN - 875623606 AB - With the recent and first conditionally-approved animal drug for a major species under the Minor Use and Minor Species Animal Health Act, Kinavet-CA1 (masitinib mesylate), it may be helpful for veterinarians to understand the differences between conditionally-approved animal drug products and fully-approved products. Kinavet-CA1 was conditionally-approved for the treatment of recurrent (post-surgery) or nonresectable Grade II or III cutaneous mast cell tumors in dogs that have not previously received radiotherapy and/or chemotherapy except corticosteroids. JF - FDA Veterinarian AU - Alvey, Laura Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Federal legislation KW - FDA approval KW - Chemotherapy KW - Animal care KW - Veterinarians KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Conditional+Approval+of+Animal+Drugs+-+What+Does+This+Mean+for+Veterinarians%3F&rft.au=Alvey%2C+Laura&rft.aulast=Alvey&rft.aufirst=Laura&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - Celebration Time! A Look at Vet2011 and CVM Veterinarians AN - 875623604 AB - National and international veterinary groups, and even the US Congress, proclaimed 2011 as World Veterinary Year. This yearlong celebration, also called Vet2011, is a salute to all the veterinarians, both past and present, who have dedicated their careers to protecting public and animal health. Over half of the federal veterinarians with Food and Drug Administration work at the Center for Veterinary Medicine. JF - FDA Veterinarian AU - McLean, Melanie Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Veterinarians KW - Government agencies KW - Veterinary medicine KW - Careers KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Celebration+Time%21+A+Look+at+Vet2011+and+CVM+Veterinarians&rft.au=McLean%2C+Melanie&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA; Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - Historic Changes to the Food Safety System AN - 875623603 AB - The FDA Food Safety Modernization Act (FSMA) is the first large-scale overhaul of FDA's food safety system since the Food, Drug, and Cosmetic Act was passed in 1938. FSMA, signed into law by Pres Obama on Jan 4, 2011, focuses on prevention and risk-based analysis. Based on recent data from the Centers for Disease Control and Prevention, an estimated one in six Americans experience foodborne illness each year. JF - FDA Veterinarian AU - Roy, Kelly Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Food safety KW - Federal legislation KW - Risk assessment KW - Disease prevention KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Adult+psychotherapy+from+the+perspectives+of+attachment+theory+and+psychoanalysis&rft.au=Eagle%2C+Morris%3BWolitzky%2C+David+L.&rft.aulast=Eagle&rft.aufirst=Morris&rft.date=2009-01-01&rft.volume=&rft.issue=&rft.spage=351&rft.isbn=1-59385-998-8&rft.btitle=Attachment+theory+and+research+in+clinical+work+with+adults&rft.title=Attachment+theory+and+research+in+clinical+work+with+adults&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - CVM Aquaculture Specialists Discuss Sea Lice Products with Norway Delegation AN - 875623600 AB - Center for Veterinary Medicine aquaculture experts met with a delegation from Norway's Ministry of Fisheries and Coastal Affairs, Food Safety Authority, and Embassy to discuss US requirements concerning drugs used to treat farm-raised salmon. The delegation explained that Norwegian producers follow the drug withdrawal times established in Europe to avoid unsafe drug residues in the salmon. No sea lice products are approved in the United States, so imports of salmon with residues of the products are illegal. JF - FDA Veterinarian AU - Scheid, Jon Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Aquaculture KW - Experts KW - Salmon KW - Crustaceans KW - Drugs KW - United States--US KW - Norway UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Aquaculture+Specialists+Discuss+Sea+Lice+Products+with+Norway+Delegation&rft.au=Scheid%2C+Jon&rft.aulast=Scheid&rft.aufirst=Jon&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - CVM's Revamped New Employee Orientation AN - 875623599 AB - The Office of Management began conducting a revised Center for Veterinary Medicine New Employee Orientation for all new hires. The revamped New Employee Orientation is an integral part of the Center's onboarding program, aimed at welcoming new employees into their positions and sharing with them the information they will need to be successful in their new work environments. JF - FDA Veterinarian AU - Bradbury, Shannon Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Orientations KW - New employees KW - Veterinarians KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM%27s+Revamped+New+Employee+Orientation&rft.au=Bradbury%2C+Shannon&rft.aulast=Bradbury&rft.aufirst=Shannon&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - AAVPT Hosts CVM Workshop on the Veterinary Drug Life Cycle AN - 875623598 AB - More than a year's hard work came to fruition when Center for Veterinary Medicine experts participated in a workshop from Feb 28 to Mar 4, 2011, at the Bolger Center in Potomac, Md. The workshop, called the "American Academy of Veterinary Pharmacology & Therapeutics Veterinary Drug Regulatory Life Cycle (A to Z)," covered the life cycle of an approved animal drug from the drug's early development to its life on a veterinarian's pharmacy shelf and its use in animals. JF - FDA Veterinarian AU - Stamper, Carmela Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Workshops KW - Veterinary services KW - Product life cycle KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=AAVPT+Hosts+CVM+Workshop+on+the+Veterinary+Drug+Life+Cycle&rft.au=Stamper%2C+Carmela&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - GEN T1 - Reporting Veterinary Problems at FDA - Yes! No! Maybe So! AN - 875623597 AB - With so many different veterinary products and services available, it can be difficult to know how to report a problem when something goes wrong. Each week, the FDA's Center for Veterinary Medicine (CVM) receives several calls and emails from consumers trying to report a problem with their animal's medication, vaccine, or flea and tick product. While CVM's Communications Staff is happy to direct consumers to the appropriate resources, it may be helpful to know that there are other government and non-government organizations that can be contacted when there is a problem with an animal product or service. JF - FDA Veterinarian AU - Steel, Ashley Y1 - 2011/04/27/ PY - 2011 DA - 2011 Apr 27 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 1 KW - Veterinary Science KW - Veterinary services KW - Veterinary medicine KW - FDA approval KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875623597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Reporting+Veterinary+Problems+at+FDA+-+Yes%21+No%21+Maybe+So%21&rft.au=Steel%2C+Ashley&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2011-04-27&rft.volume=&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 27, 2011 N1 - Last updated - 2011-07-09 ER - TY - JOUR T1 - Monitoring botulinum neurotoxin a activity with peptide-functionalized quantum dot resonance energy transfer sensors. AN - 863767028; 21361387 AB - Botulinum neurotoxins (BoNTs) are extremely potent bacterial toxins that contaminate food supplies along with having a high potential for exploitation as bioterrorism agents. There is a continuing need to rapidly and sensitively detect exposure to these toxins and to verify their active state, as the latter directly affects diagnosis and helps provide effective treatments. We investigate the use of semiconductor quantum dot (QD)-peptide Förster resonance energy transfer (FRET) assemblies to monitor the activity of the BoNT serotype A light chain protease (LcA). A modular LcA peptide substrate was designed and optimized to contain a central LcA recognition/cleavage region, a unique residue to allow labeling with a Cy3 acceptor dye, an extended linker-spacer sequence, and a terminal oligohistidine that allows for final ratiometric peptide-QD-self-assembly. A number of different QD materials displaying charged or PEGylated surface-coatings were evaluated for their ability to self-assemble dye-labeled LcA peptide substrates by monitoring FRET interactions. Proteolytic assays were performed utilizing either a direct peptide-on-QD format or alternatively an indirect pre-exposure of peptide to LcA prior to QD assembly. Variable activities were obtained depending on QD materials and formats used with the most sensitive pre-exposure assay result demonstrating a 350 pM LcA limit of detection. Modeling the various QD-peptide sensor constructs provided insight into how the resulting assembly architecture influenced LcA recognition interactions and subsequent activity. These results also highlight the unique roles that both peptide design and QD features, especially surface-capping agents, contribute to overall sensor activity. JF - ACS nano AU - Sapsford, Kim E AU - Granek, Jessica AU - Deschamps, Jeffrey R AU - Boeneman, Kelly AU - Blanco-Canosa, Juan Bautista AU - Dawson, Philip E AU - Susumu, Kimihiro AU - Stewart, Michael H AU - Medintz, Igor L AD - Division of Biology, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. Kim.Sapsford@fda.hhs.gov Y1 - 2011/04/26/ PY - 2011 DA - 2011 Apr 26 SP - 2687 EP - 2699 VL - 5 IS - 4 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Models, Molecular KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Hydrolysis KW - Protein Conformation KW - Quantum Dots KW - Fluorescence Resonance Energy Transfer KW - Botulinum Toxins, Type A -- toxicity KW - Botulinum Toxins, Type A -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863767028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+nano&rft.atitle=Monitoring+botulinum+neurotoxin+a+activity+with+peptide-functionalized+quantum+dot+resonance+energy+transfer+sensors.&rft.au=Sapsford%2C+Kim+E%3BGranek%2C+Jessica%3BDeschamps%2C+Jeffrey+R%3BBoeneman%2C+Kelly%3BBlanco-Canosa%2C+Juan+Bautista%3BDawson%2C+Philip+E%3BSusumu%2C+Kimihiro%3BStewart%2C+Michael+H%3BMedintz%2C+Igor+L&rft.aulast=Sapsford&rft.aufirst=Kim&rft.date=2011-04-26&rft.volume=5&rft.issue=4&rft.spage=2687&rft.isbn=&rft.btitle=&rft.title=ACS+nano&rft.issn=1936-086X&rft_id=info:doi/10.1021%2Fnn102997b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-28 N1 - Date created - 2011-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nn102997b ER - TY - JOUR T1 - Novel hemotrophic mycoplasma identified in naturally infected California sea lions (Zalophus californianus) AN - 907160980; 14439944 AB - The hemoplasmas are the trivial name for a group of erythrocyte-parasitizing, non-cultivable in vitro bacteria of the genus Mycoplasma that have been described in several mammalian hosts worldwide. This study is the first report of hemoplasmas in marine mammals. EDTA anticoagulated whole blood samples from 137 California sea lions (Zalophus californianus) and 20 northern elephant seals (Mirounga angustirostris) admitted to the Marine Mammal Center (Sausalito, CA; www.marinemammalcenter.org) or live captured in Oregon were collected during 2008. Hemoplasma-specific genomic DNA was detected in blood samples from 12.4% California sea lions tested using PCR. Hemoplasma PCR positive blood specimens also were tested in reverse transcription polymerase chain reaction (RT-PCR) using the hemoplasma-specific primers for the 16S and 23S rRNA genes. The RT-PCR showed the presence the hemoplasmal rRNA, strongly suggesting the presence of potentially viable hemoplasmas in the bloodstream of the animals. BLAST search and phylogenetic analysis of the 16S rRNA sequences of the hemoplasma from California sea lions revealed that the organism is a novel hemoplasma species with only 92.1% of its nucleotide similarity to the 16S rRNA gene of the previously described hemoplasma species of alpacas, Candidatus Mycoplasma haemolamae. Thus, due to low level of genetic similarity of the hemoplasma to other described hemoplasmas and the mammalian host in which the hemoplasma was detected we propose that this novel hemoplasma species has been given the provisional name Candidatus Mycoplasma haemozalophi sp. nov. JF - Veterinary Microbiology AU - Volokhov, Dmitriy V AU - Norris, Tenaya AU - Rios, Carlos AU - Davidson, Maureen K AU - Messick, Joanne B AU - Gulland, Frances M AU - Chizhikov, Vladimir E AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, United States, dmitriy.volokhov@fda.hhs.gov Y1 - 2011/04/21/ PY - 2011 DA - 2011 Apr 21 SP - 262 EP - 268 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 149 IS - 1-2 SN - 0378-1135, 0378-1135 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - Hemoplasma KW - Blood KW - California sea lions KW - rRNA 23S KW - Nucleotide sequence KW - Reverse transcription KW - rRNA KW - INE, USA, California KW - INE, USA, California, Sausalito KW - Polymerase chain reaction KW - genomics KW - Mycoplasma KW - Phylogenetics KW - Phylogeny KW - Marine KW - Transcription KW - Zalophus californianus KW - Nucleotides KW - INE, USA, Oregon KW - Mirounga angustirostris KW - Marine mammals KW - Microbiology KW - DNA KW - Primers KW - rRNA 16S KW - Edetic acid KW - New species KW - J 02310:Genetics & Taxonomy KW - Q1 08484:Species interactions: parasites and diseases KW - O 1050:Vertebrates, Urochordates and Cephalochordates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907160980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+Microbiology&rft.atitle=Novel+hemotrophic+mycoplasma+identified+in+naturally+infected+California+sea+lions+%28Zalophus+californianus%29&rft.au=Volokhov%2C+Dmitriy+V%3BNorris%2C+Tenaya%3BRios%2C+Carlos%3BDavidson%2C+Maureen+K%3BMessick%2C+Joanne+B%3BGulland%2C+Frances+M%3BChizhikov%2C+Vladimir+E&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2011-04-21&rft.volume=149&rft.issue=1-2&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Veterinary+Microbiology&rft.issn=03781135&rft_id=info:doi/10.1016%2Fj.vetmic.2010.10.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Marine mammals; Microbiology; DNA; Transcription; Polymerase chain reaction; Phylogenetics; Nucleotides; New species; Phylogeny; rRNA; rRNA 23S; Primers; genomics; rRNA 16S; Reverse transcription; Edetic acid; Mirounga angustirostris; Zalophus californianus; Mycoplasma; INE, USA, Oregon; INE, USA, California, Sausalito; INE, USA, California; Marine DO - http://dx.doi.org/10.1016/j.vetmic.2010.10.026 ER - TY - JOUR T1 - Employing ultra high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis of Stevia rebaudiana extracts AN - 1635019703; 15117677 AB - Stevia rebaudiana extracts and plant materials are increasingly used as natural sweeteners. Polyphenolic and stevioside compounds contained in S. rebaudiana extracts were separated by comprehensive LC. A polyamine column operated in normal phase mode was used for the first dimension separation (D1), and a UHPLC C18 column operated in reversed phase mode was used for the second dimension separation (D2). The sub-2 [micro]m column (2.1 mm x 30 mm, maintained at 70 [deg]C) and the UHPLC pump employed for D2 elution allowed a separation/cycle time of 20 s, with a backpressure oscillating between 805 and 922 bar at 3.4 mL/min. The reduced D2 cycle time allowed 3-12 D2 samplings for each peak eluted by D1. Polyphenolic and stevioside compounds were identified by combining the information coming from the position of the compounds in the 2D plot and UV spectra with that of reference materials. JF - Journal of Chromatography A AU - Cacciola, Francesco AU - Delmonte, Pierluigi AU - Jaworska, Karolina AU - Dugo, Paola AU - Mondello, Luigi AU - Rader, Jeanne I AD - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Pkwy, HFS-717, College Park, MD, 20740, USA, fcacciola@pharma.unime.it Y1 - 2011/04/15/ PY - 2011 DA - 2011 Apr 15 SP - 2012 EP - 2018 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 15 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Stevia rebaudiana KW - Comprehensive LC KW - UHPLC column KW - Glycosides KW - Molecular structure KW - Chromatographic techniques KW - Ultraviolet radiation KW - High Pressure KW - Liquid Chromatography KW - Pumps KW - Sampling KW - Pressure KW - Q5 08502:Methods and instruments KW - SW 6070:Materials KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635019703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Employing+ultra+high+pressure+liquid+chromatography+as+the+second+dimension+in+a+comprehensive+two-dimensional+system+for+analysis+of+Stevia+rebaudiana+extracts&rft.au=Cacciola%2C+Francesco%3BDelmonte%2C+Pierluigi%3BJaworska%2C+Karolina%3BDugo%2C+Paola%3BMondello%2C+Luigi%3BRader%2C+Jeanne+I&rft.aulast=Cacciola&rft.aufirst=Francesco&rft.date=2011-04-15&rft.volume=1218&rft.issue=15&rft.spage=2012&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.08.081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Molecular structure; Chromatographic techniques; Ultraviolet radiation; Pressure; Liquid Chromatography; High Pressure; Pumps; Sampling DO - http://dx.doi.org/10.1016/j.chroma.2010.08.081 ER - TY - CPAPER T1 - A risk/benefit view of safety pharmacogenomics T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313053568; 6086028 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Zineh, Issam Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - pharmacogenomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313053568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=A+risk%2Fbenefit+view+of+safety+pharmacogenomics&rft.au=Zineh%2C+Issam&rft.aulast=Zineh&rft.aufirst=Issam&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Complexity in the analysis of pharmacogenomic data T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313053417; 6086025 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Mendrick, Donna Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Data processing KW - pharmacogenomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313053417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Complexity+in+the+analysis+of+pharmacogenomic+data&rft.au=Mendrick%2C+Donna&rft.aulast=Mendrick&rft.aufirst=Donna&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Need for improved clinical trial design and improved standardization of clinical trial data to improve public health measures T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313038616; 6085931 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Temple, Robert Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Clinical trials KW - Standardization KW - Public health KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Need+for+improved+clinical+trial+design+and+improved+standardization+of+clinical+trial+data+to+improve+public+health+measures&rft.au=Temple%2C+Robert&rft.aulast=Temple&rft.aufirst=Robert&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - How pharmacology and toxicology can help meet the demands of FDA's expanding scientific portfolio T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313038604; 6085930 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Seyfert-Margolis, Vicki Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Pharmacology KW - portfolios KW - Toxicology KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=How+pharmacology+and+toxicology+can+help+meet+the+demands+of+FDA%27s+expanding+scientific+portfolio&rft.au=Seyfert-Margolis%2C+Vicki&rft.aulast=Seyfert-Margolis&rft.aufirst=Vicki&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pharmacogenetics and personalized medicine: Facing the challenges of bridging the gap between science and utility T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313038245; 6086022 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Abernethy, Darrell Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Pharmacogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313038245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Pharmacogenetics+and+personalized+medicine%3A+Facing+the+challenges+of+bridging+the+gap+between+science+and+utility&rft.au=Ein-Dor%2C+Tsachi%3BHirschberger%2C+Gilad&rft.aulast=Ein-Dor&rft.aufirst=Tsachi&rft.date=2016-08-01&rft.volume=25&rft.issue=4&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Current+Directions+in+Psychological+Science&rft.issn=09637214&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Progress in biomarkers and translational strategies for drug development T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313037584; 6085934 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Woodcock, Janet Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - Bioindicators KW - Drug development KW - Translation KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313037584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Progress+in+biomarkers+and+translational+strategies+for+drug+development&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bioinformatics and pharmacoepidemiology: making sense of data. T2 - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AN - 1313037561; 6085933 JF - 2011 Conference on Experimental Biology of the American Society for Pharmacology and Experimental Therapeutics AU - Abernathy, Darrell Y1 - 2011/04/09/ PY - 2011 DA - 2011 Apr 09 KW - bioinformatics KW - Data processing KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313037561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.atitle=Bioinformatics+and+pharmacoepidemiology%3A+making+sense+of+data.&rft.au=Abernathy%2C+Darrell&rft.aulast=Abernathy&rft.aufirst=Darrell&rft.date=2011-04-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Conference+on+Experimental+Biology+of+the+American+Society+for+Pharmacology+and+Experimental+Therapeutics&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/EB2011/Scientific_Program_Index/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells AN - 872139945; 14919815 AB - The development of improved vaccines against Mycobacterium tuberculosis has been hindered by a limited understanding of the immune correlates of anti-tuberculosis protective immunity. In this study, we examined the relationship between long-term anti-tuberculosis protection and the mycobacterial-specific CD4 multifunctional T (MFT) cell responses induced by five different TB vaccines (live-attenuated, subunit, viral vectored, plasmid DNA, and combination vaccines) in a mouse model of pulmonary tuberculosis. In a 14-month experiment, we showed that TB vaccine-induced CD4 T cell responses were heterogenous. Antigen-specific monofunctional CD4 T cells expressing single cytokines and MFT CD4 T cells expressing multiple cytokines (IFN- gamma and TNF- alpha , IFN- gamma and IFN- gamma , TNF- alpha , and IL-2, and all three cytokines) were identified after the immunizations. Interestingly, compared to the monofunctional cells, significantly higher median fluorescent intensities (MFIs) for IFN- gamma and TNF- alpha were detected for triple-positive MFT CD4 T cells induced by the most protective vaccines while modest differences in relative MFI values were seen for the less protective preparations. Most importantly during the 14-month study, the levels of vaccine-induced pulmonary and splenic protective immunity correlated with the frequency and the integrated MFI (iMFI, frequency x MFI) values of triple-positive CD4 T cells that were induced by the same vaccines. These data support efforts to use MFT cell analyses as a measure of TB vaccine immunogenicity in human immunization studies. JF - Vaccine AU - Derrick, Steven C AU - Yabe, Idalia M AU - Yang, Amy AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, United States, sheldon.morris@fda.hhs.gov Y1 - 2011/04/05/ PY - 2011 DA - 2011 Apr 05 SP - 2902 EP - 2909 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 29 IS - 16 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Animal models KW - Vaccines KW - Mycobacterium tuberculosis KW - V:22350 KW - F:06905 KW - J:02350 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872139945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Vaccine-induced+anti-tuberculosis+protective+immunity+in+mice+correlates+with+the+magnitude+and+quality+of+multifunctional+CD4+T+cells&rft.au=Derrick%2C+Steven+C%3BYabe%2C+Idalia+M%3BYang%2C+Amy%3BMorris%2C+Sheldon+L&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2011-04-05&rft.volume=29&rft.issue=16&rft.spage=2902&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.02.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vaccines; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1016/j.vaccine.2011.02.010 ER - TY - JOUR T1 - Neurovirulence safety testing of mumps vaccines--historical perspective and current status. AN - 860187505; 21334386 AB - Many live, attenuated viral vaccines are derived from wild type viruses with known neurovirulent properties. To assure the absence of residual neurotoxicity, pre-clinical neurovirulence safety testing of candidate vaccines is performed. For mumps virus, a highly neurotropic virus, neurovirulence safety testing is performed in monkeys. However, laboratory studies suggest an inability of this test to correctly discern among virus strains of varying neurovirulence potential in man, and, further, some vaccines found to be neuroattenuated in monkeys were later found to be neurovirulent in humans when administered in large numbers. Over the past decade, concerted efforts have been made to replace monkey-based neurovirulence safety testing with more informative, alternative methods. This review summarizes the current status of mumps vaccine neurovirulence safety testing and insights into models currently approved and those under development. Published by Elsevier Ltd. JF - Vaccine AU - Rubin, S A AU - Afzal, M A AD - Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA. steven.rubin@fda.hhs.gov Y1 - 2011/04/05/ PY - 2011 DA - 2011 Apr 05 SP - 2850 EP - 2855 VL - 29 IS - 16 KW - Mumps Vaccine KW - 0 KW - Vaccines, Attenuated KW - Index Medicus KW - Animals KW - History, 20th Century KW - History, 21st Century KW - Humans KW - Mice KW - Haplorhini KW - Virulence KW - Rats KW - Callithrix KW - Vaccines, Attenuated -- adverse effects KW - Mumps virus -- pathogenicity KW - Cricetinae KW - Vaccines, Attenuated -- history KW - Mumps Vaccine -- adverse effects KW - Meningitis, Aseptic -- chemically induced KW - Animal Testing Alternatives -- trends KW - Mumps Vaccine -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860187505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Neurovirulence+safety+testing+of+mumps+vaccines--historical+perspective+and+current+status.&rft.au=Rubin%2C+S+A%3BAfzal%2C+M+A&rft.aulast=Rubin&rft.aufirst=S&rft.date=2011-04-05&rft.volume=29&rft.issue=16&rft.spage=2850&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2011.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-08 N1 - Date created - 2011-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2011.02.005 ER - TY - JOUR T1 - p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene. AN - 858780246; 21324376 AB - A 2-year rat tumor bioassay testing whole body exposure to naphthalene (NA) vapor found a significant increase in nasal respiratory epithelial adenomas in male rats and in olfactory epithelial neuroblastomas in female rats. To obtain mechanistic insight into NA-induced nasal carcinogenesis, NA dose-response was characterized in nasal epithelium using a tumor-relevant endpoint. Specifically, levels of p53 codon 271 CGT to CAT mutation were measured in nasal respiratory and olfactory epithelium of NA-exposed male and female rats by allele-specific competitive blocker-PCR (ACB-PCR). Male and female, 8-9 week-old F344 rats (5 rats/group) were exposed to 0, 0.1, 1.0, 10, and 30ppm NA vapor for 13 weeks (6h/day, 5 days/week). The geometric mean p53 mutant fraction (MF) levels in nasal epithelium of control treatment groups ranged between 2.05 × 10(-5) and 3.05 × 10(-5). No significant dose-related changes in p53 mutant fraction (MF) were observed in the olfactory or respiratory epithelia of female rats. However, statistically significant treatment-related differences were observed in male respiratory and olfactory epithelium, with the p53 MF in the respiratory epithelium of male rats exposed to 30ppm NA significantly lower than that in controls. Further, a significant trend of decreasing p53 MF with increasing dose was observed in the male respiratory epithelium. Of the tissue types analyzed, respiratory epithelium is the most sensitive to the cytotoxic effects of NA, suggesting cytotoxicity may be responsible for the loss of p53 mutation. Because ACB-PCR has been used successfully to detect the effects of known mutagenic carcinogens, the absence of any significant increases in p53 MF associated with NA exposure adds to the weight of evidence that NA does not operate through a directly mutagenic mode of action. Published by Elsevier B.V. JF - Mutation research AU - Meng, Fanxue AU - Wang, Yiying AU - Myers, Meagan B AU - Wong, Brian A AU - Gross, Elizabeth A AU - Clewell, Harvey J AU - Dodd, Darol E AU - Parsons, Barbara L AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/04/03/ PY - 2011 DA - 2011 Apr 03 SP - 199 EP - 205 VL - 721 IS - 2 SN - 0027-5107, 0027-5107 KW - Carcinogens KW - 0 KW - Codon KW - Naphthalenes KW - naphthalene KW - 2166IN72UN KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Inhalation Exposure KW - Male KW - Female KW - Genes, p53 KW - Carcinogens -- toxicity KW - Nasal Mucosa -- drug effects KW - Naphthalenes -- toxicity KW - Mutation KW - Olfactory Mucosa -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858780246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=p53+codon+271+CGT+to+CAT+mutant+fraction+does+not+increase+in+nasal+respiratory+and+olfactory+epithelia+of+rats+exposed+to+inhaled+naphthalene.&rft.au=Meng%2C+Fanxue%3BWang%2C+Yiying%3BMyers%2C+Meagan+B%3BWong%2C+Brian+A%3BGross%2C+Elizabeth+A%3BClewell%2C+Harvey+J%3BDodd%2C+Darol+E%3BParsons%2C+Barbara+L&rft.aulast=Meng&rft.aufirst=Fanxue&rft.date=2011-04-03&rft.volume=721&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-23 N1 - Date created - 2011-03-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2011.02.004 ER - TY - CPAPER T1 - Identification of interleukin 4 receptor alpha (IL-4Ralpha) as a biomarker of advanced stage human bladder carcinoma T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313036857; 6096681 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Joshi, Bharat AU - Leland, Pamela AU - Puri, Raj Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Bioindicators KW - Urinary bladder KW - Interleukin 4 receptors KW - Carcinoma KW - biomarkers KW - Tumors KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313036857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Identification+of+interleukin+4+receptor+alpha+%28IL-4Ralpha%29+as+a+biomarker+of+advanced+stage+human+bladder+carcinoma&rft.au=Joshi%2C+Bharat%3BLeland%2C+Pamela%3BPuri%2C+Raj&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A novel combination therapeutic approach for targeting murine cancers with IL-13 receptor alpha 2 DNA vaccine and an immunotoxin T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313028777; 6096934 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Nakashima, Hideyuki AU - Joshi, Bharat AU - Husain, Syed AU - Puri, Raj Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - vaccines KW - Immunotoxins KW - DNA vaccines KW - Interleukin 13 KW - Vaccines KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313028777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=A+novel+combination+therapeutic+approach+for+targeting+murine+cancers+with+IL-13+receptor+alpha+2+DNA+vaccine+and+an+immunotoxin&rft.au=Nakashima%2C+Hideyuki%3BJoshi%2C+Bharat%3BHusain%2C+Syed%3BPuri%2C+Raj&rft.aulast=Nakashima&rft.aufirst=Hideyuki&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Over-expression of microRNA-221 causes neoplastic cell transformation through induction of the epithelial-mesenchymal transition in non-tumorigenic liver cells T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1313026365; 6095646 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Tryndyak, Volodymyr AU - Beland, Frederick AU - Pogribny, Igor Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Liver KW - miRNA KW - Hepatocytes KW - Transformation KW - Overexpression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313026365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Over-expression+of+microRNA-221+causes+neoplastic+cell+transformation+through+induction+of+the+epithelial-mesenchymal+transition+in+non-tumorigenic+liver+cells&rft.au=Tryndyak%2C+Volodymyr%3BBeland%2C+Frederick%3BPogribny%2C+Igor&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312999480; 6097313 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook, Beverly Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - Cancer KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2013/previous-annual-meetings/annual-meeting-2011/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Upregulation of the human equilibrative nucleoside transporter 1 (hENT1) expression by indole-3-carbinol (I3C) in pancreatic cancer cell lines T2 - 102nd Annual Meeting of the American Association for Cancer Research AN - 1312995751; 6095955 JF - 102nd Annual Meeting of the American Association for Cancer Research AU - Wang, Honggang AU - Word, Beverly AU - Lyn-Cook, Berverly Y1 - 2011/04/02/ PY - 2011 DA - 2011 Apr 02 KW - pancreatic cancer KW - Indole-3-carbinol KW - Tumor cell lines KW - nucleoside transporter KW - Pancreatic cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Upregulation+of+the+human+equilibrative+nucleoside+transporter+1+%28hENT1%29+expression+by+indole-3-carbinol+%28I3C%29+in+pancreatic+cancer+cell+lines&rft.au=Wang%2C+Honggang%3BWord%2C+Beverly%3BLyn-Cook%2C+Berverly&rft.aulast=Wang&rft.aufirst=Honggang&rft.date=2011-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=102nd+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2012/previous-annual-meetings/annual-meeting-2011/program.aspx#AM2011_prog_details LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Antimicrobial Resistance and Molecular Subtyping of Campylobacter jejuni and Campylobacter coli from Retail Meats AN - 904478211; 14873350 AB - Campylobacter isolates (n = 297; 202 C. jejuni and 95 C. coli isolates) recovered from 2,513 retail meat samples (chicken breasts, ground turkey, ground beef, and pork chops) were examined for antimicrobial susceptibility. The isolates were further analyzed for genetic relatedness by pulsed-field gel electrophoresis (PFGE) using SmaI and KpnI restriction enzymes, and a subset of isolates (n = 174) were subtyped by multilocus sequence typing (MLST). The resistance most frequently observed was that to doxycycline (27.6%), followed by ciprofloxacin (13.8%) and erythromycin (6.4%). All isolates were susceptible to gentamicin and meropenem. C. coli showed higher resistance to doxycycline than did C. jejuni (42.1 versus 20.8%) and lower resistance to ciprofloxacin than did C. jejuni (10.5 versus 15.3%). Erythromycin resistance was only observed in C. coli. PFGE using SmaI plus KpnI digestion generated 168 clusters from 297 isolates: 115 from C. jejuni and 53 from C. coli. MLST revealed 44 sequence types (STs) under 10 clonal complexes from 120 C. jejuni and 27 STs under two clonal complexes from 54 C. coli. There was a positive association between PFGE and STs; however, PFGE showed greater discriminatory power than MLST. Subtyping data did not correlate with antimicrobial resistance phenotypes. JF - Journal of Food Protection AU - Wang, X AU - Zhao, S AU - Harbottle, H AU - Tran, T AU - Blickenstaff, K AU - Abbott, J AU - Meng, J AD - College of Food Science and Engineering, Northwest A&F University, Yanglin, Shaanxi, China; 2 Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, USA; and 3 Department of Nutrition and Food Scienceand Joint Institute for Food Science and Applied Nutrition (JIFSAN), University of Maryland, College Park, Maryland, USAMS 10-432: Received 2 October 2010/Accepted 4 January 2011* Author for correspondence. Tel: 301405-7976; Fax: 301-314-3313. E-mail: jmeng[AT]umd.edu. Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 616 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 74 IS - 4 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts KW - Data processing KW - Drug resistance KW - Pork KW - Campylobacter coli KW - Enzymes KW - Erythromycin KW - Antimicrobial agents KW - multilocus sequence typing KW - Digestion KW - Gentamicin KW - Meat KW - Ciprofloxacin KW - Beef KW - Campylobacter jejuni KW - Meropenem KW - Pulsed-field gel electrophoresis KW - Doxycycline KW - J 02410:Animal Diseases KW - X 24320:Food Additives & Contaminants KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904478211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Antimicrobial+Resistance+and+Molecular+Subtyping+of+Campylobacter+jejuni+and+Campylobacter+coli+from+Retail+Meats&rft.au=Wang%2C+X%3BZhao%2C+S%3BHarbottle%2C+H%3BTran%2C+T%3BBlickenstaff%2C+K%3BAbbott%2C+J%3BMeng%2C+J&rft.aulast=Wang&rft.aufirst=X&rft.date=2011-04-01&rft.volume=74&rft.issue=4&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 16 N1 - Last updated - 2012-05-07 N1 - SubjectsTermNotLitGenreText - Data processing; Drug resistance; Pork; Enzymes; Erythromycin; multilocus sequence typing; Antimicrobial agents; Meat; Gentamicin; Digestion; Ciprofloxacin; Beef; Meropenem; Pulsed-field gel electrophoresis; Doxycycline; Campylobacter jejuni; Campylobacter coli ER - TY - JOUR T1 - A Retrospective Cohort Study of Structured Abstracts in MEDLINE, 1992-2006 AN - 902065051; 201108696 AB - Structured abstracts contain distinct labeled sections (e.g.'RESULTS'). MEDLINE is an online database containing English-language abstracts of articles appearing in the journals that are indexed by the U.S. National Library of Medicine (NLM). To assess the usefulness of MEDLINE structured abstracts in enhancing bibliographic retrieval, they were reviewed by NLM between 1989 and 1991. Among the findings: the structured abstract formats prescribed by different journals varied considerably; structured abstracts were becoming increasing popular; MEDLINE records with structured abstracts typically tended to have more access points than MEDLINE records as a whole. This article discusses the results of a retrospective cohort study aimed at measuring and characterizing the growth in structured abstracts in MEDLINE since 1991, with a view again toward exploring their utility in enhancing information display and retrieval. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Ripple, Anna M AU - Mork, James G AU - Knecht, Lou S AU - Humphreys, Betsy L AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 ripple@nlm.nih.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 160 EP - 163 PB - Medical Library Association, Chicago, IL VL - 99 IS - 2 SN - 1536-5050, 1536-5050 KW - MEDLINE KW - Abstracts KW - Online information retrieval KW - article KW - 13.23: ONLINE DATABASES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902065051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=A+Retrospective+Cohort+Study+of+Structured+Abstracts+in+MEDLINE%2C+1992-2006&rft.au=Ripple%2C+Anna+M%3BMork%2C+James+G%3BKnecht%2C+Lou+S%3BHumphreys%2C+Betsy+L&rft.aulast=Ripple&rft.aufirst=Anna&rft.date=2011-04-01&rft.volume=99&rft.issue=2&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/ L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Abstracts; Online information retrieval; MEDLINE ER - TY - JOUR T1 - Trends in meat consumption in the USA AN - 899149288; 15748188 AB - To characterize the trends, distribution, potential determinants and public health implications of meat consumption within the USA. We examined temporal trends in meat consumption using food availability data from the FAO and US Department of Agriculture (USDA), and further evaluated the meat intake by type (red, white, processed) in the National Health and Nutrition Examination Surveys (NHANES) linked to the MyPyramid Equivalents Database (MPED). Overall meat consumption has continued to rise in the USA and the rest of the developed world. Despite a shift towards higher poultry consumption, red meat still represents the largest proportion of meat consumed in the USA (58 %). Twenty-two per cent of the meat consumed in the USA is processed. According to the NHANES 2003-2004, total meat intake averaged 128 g/d. The type and quantities of meat reported varied by education, race, age and gender. Given the plausible epidemiological evidence for red and processed meat intake in cancer and chronic disease risk, understanding the trends and determinants of meat consumption in the USA, where meat is consumed at more than three times the global average, should be particularly pertinent to researchers and other public health professionals aiming to reduce the global burden of chronic disease. JF - Public Health Nutrition AU - Daniel, Carrie R AU - Cross, Amanda J AU - Koebnick, Corinna AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Bethesda, MD 20892, USA, Carrie.Daniel@nih.hhs.gov Carrie.Daniel@nih.hhs.gov Carrie.Daniel@nih.hhs.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 575 EP - 583 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 14 IS - 4 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - USA KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899149288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Trends+in+meat+consumption+in+the+USA&rft.au=Daniel%2C+Carrie+R%3BCross%2C+Amanda+J%3BKoebnick%2C+Corinna%3BSinha%2C+Rashmi&rft.aulast=Daniel&rft.aufirst=Carrie&rft.date=2011-04-01&rft.volume=14&rft.issue=4&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980010002077 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - meat; USA DO - http://dx.doi.org/10.1017/S1368980010002077 ER - TY - JOUR T1 - Stop Bullying Now! A Federal Campaign for Bullying Prevention and Intervention AN - 896183085; 201103935 AB - This commentary describes a national bullying prevention effort, called Stop Bullying Now!, which aims to increase awareness of the problem of bullying and related research findings, and disseminate evidence-based approaches to prevention. Drawing on the special issue's main theme of the social context of bullying, the author describes the process used to develop the Stop Bullying Now! campaign, highlights the importance of interagency approaches to bullying prevention, and provides examples of social marketing and media activities aimed to prevent bullying on a national scale. Adapted from the source document. JF - Journal of School Violence AU - Bryn, Stephanie AD - Health Resources and Services Administration, Rockville, Maryland, USA Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 213 EP - 219 PB - Taylor & Francis, Philadelphia PA VL - 10 IS - 2 SN - 1538-8220, 1538-8220 KW - bullying prevention United States interagency youth development KW - Consciousness KW - Prevention KW - Social Behavior KW - Intervention KW - Evidence Based Practice KW - Aggression KW - Mass Media KW - Social Environment KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/896183085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Violence&rft.atitle=Stop+Bullying+Now%21+A+Federal+Campaign+for+Bullying+Prevention+and+Intervention&rft.au=Bryn%2C+Stephanie&rft.aulast=Bryn&rft.aufirst=Stephanie&rft.date=2011-04-01&rft.volume=10&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Violence&rft.issn=15388220&rft_id=info:doi/10.1080%2F15388220.2011.557313 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-10-03 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Aggression; Prevention; Evidence Based Practice; Social Behavior; Consciousness; Social Environment; Mass Media; Intervention DO - http://dx.doi.org/10.1080/15388220.2011.557313 ER - TY - JOUR T1 - Assessment of the contribution of in-situ combustion of coal to greenhouse gas emission; based on a comparison of Chinese mining information to previous remote sensing estimates AN - 881451557; 2011-062540 AB - Greenhouse gas (GHG) emission from geological sources such as volcanic activity, seabed gas hydrate release, hydrocarbon seepage as well as uncontrolled combustion of fossil fuels is erratic and difficult to quantify. In this paper we assess the GHG emission due to spontaneous combustion of in-situ coal deposits ("coal fires"). This problem is aggravated by human intervention (mining activities) which on the other hand allows better constrained estimations and improved reduction strategies, provided modern mining practices are employed. In this study we present three case studies on coal fire-related GHG emission quantification on provincial scale in China, and we propose an integrated quantification aimed at the joint analyses of local knowledge, geophysical data, and remote sensing data with the objective to retrieve unbiased numbers. As a first estimate, we conclude that the emissions of GHGs from coal fires in China account for well less than 0.22% of all global fossil fuel related CO (sub 2) emissions, most likely even less than 0.1%. This is much less than the previously estimated 2-3%. JF - International Journal of Coal Geology AU - van Dijk, Paul AU - Zhang, J AU - Jun, Wang AU - Kuenzer, Claudia AU - Wolf, Karl-Heinz A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 108 EP - 119 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - Inner Mongolia China KW - mining KW - mines KW - Far East KW - coal mines KW - Xinjiang China KW - Ningxia China KW - combustion KW - carbon dioxide KW - fires KW - sedimentary rocks KW - quantitative analysis KW - coal KW - greenhouse gases KW - greenhouse effect KW - Asia KW - China KW - Wuda Syncline KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881451557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Assessment+of+the+contribution+of+in-situ+combustion+of+coal+to+greenhouse+gas+emission%3B+based+on+a+comparison+of+Chinese+mining+information+to+previous+remote+sensing+estimates&rft.au=van+Dijk%2C+Paul%3BZhang%2C+J%3BJun%2C+Wang%3BKuenzer%2C+Claudia%3BWolf%2C+Karl-Heinz&rft.aulast=van+Dijk&rft.aufirst=Paul&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.01.009 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 55 N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; carbon dioxide; China; coal; coal mines; combustion; Far East; fires; greenhouse effect; greenhouse gases; Inner Mongolia China; mines; mining; Ningxia China; quantitative analysis; remote sensing; sedimentary rocks; Wuda Syncline; Xinjiang China DO - http://dx.doi.org/10.1016/j.coal.2011.01.009 ER - TY - JOUR T1 - Remote sensing of vegetation health for reclaimed areas of Seyitomer open cast coal mine AN - 881451551; 2011-062531 AB - A remote sensing based vegetation cover monitoring and health assessment is presented and applied to a case study of the Seyitomer Lignite Enterprise (SLE) in Kutahya, Turkey. In this study, multi-temporal Landsat TM data sets were used to assist in identifying and monitoring the progress in the rehabilitation field. Evaluation was based on analyzing varying vegetation indices. In order to monitor and track the changes, which occurred from 1987 to 2006 in vegetation condition, Simple Ratio (SR) index, Reduced Simple Ratio (RSR), Normalized Difference Vegetation Index (NDVI) and Tasseled Cap Transformation analysis were employed in the study. The vegetation indices were mapped and evaluated. The result of these analyses showed that, the region has moderate to good reclamation success. As a result, it can be concluded that, the remotely sensed data are undoubtedly useful to provide up-to-date and quick data and are cost-effective in monitoring the progress of rehabilitation for large extended regions. JF - International Journal of Coal Geology AU - Erener, Arzu A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 20 EP - 26 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - imagery KW - reclamation KW - vegetation KW - coal fields KW - environmental analysis KW - Kutahya Turkey KW - sedimentary rocks KW - geographic information systems KW - quantitative analysis KW - coal KW - open-pit mining KW - lignite KW - Asia KW - Middle East KW - mines KW - surface mining KW - coal mines KW - Turkey KW - satellite methods KW - Landsat KW - information systems KW - Seyitomer Mine KW - image analysis KW - remote sensing KW - coal deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881451551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Remote+sensing+of+vegetation+health+for+reclaimed+areas+of+Seyitomer+open+cast+coal+mine&rft.au=Erener%2C+Arzu&rft.aulast=Erener&rft.aufirst=Arzu&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.009 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 33 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; coal; coal deposits; coal fields; coal mines; environmental analysis; geographic information systems; image analysis; imagery; information systems; Kutahya Turkey; Landsat; lignite; Middle East; mines; mining; open-pit mining; quantitative analysis; reclamation; remote sensing; satellite methods; sedimentary rocks; Seyitomer Mine; surface mining; Turkey; vegetation DO - http://dx.doi.org/10.1016/j.coal.2010.12.009 ER - TY - JOUR T1 - Evaluation of pollution levels at an abandoned coal mine site in Turkey with the aid of GIS AN - 881451541; 2011-062530 AB - Determination of the level of pollution at contaminated sites can be costly due to the number of samples required to identify the areas with higher contaminant concentrations. Yet, if pollution transport pathways can be found, then contamination level can be detected with fewer samples. In this case study, pollution levels at an abandoned coal mine site at Ovacik-Yaprakli (Cankiri, Turkey) are evaluated with respect to topography and surface runoff pathways derived using Geographical Information System (GIS) tools. First, surface runoff pathways are identified using ArcGIS 9.3. Then, the concentrations of trace elements (Mn, Cr, V, Cu, Ni, Zn, Ba, and Sr), pH, Fe and S contents in soil samples taken at random locations around the mine area are determined in a laboratory. In addition, pH and electrical conductivity (EC) are measured in flowing waters in-situ at different locations using pH and EC probes. The spatial distribution of pollutant concentrations is evaluated with respect to the surface runoff pathways and locations of potential contamination sources (i.e. open pit, coal storage and dump sites). Finally, the contamination level in the study area is assessed based on the limit values stated in the Soil Pollution Control Regulation of Turkey (SPCR). Results indicate that the site is contaminated with Cr, Ni, and Cu. In general, pollutant concentrations are higher close to the contamination sources and along the surface runoff pathways determined by the ArcGIS. Results indicate that GIS can aid in locating the areas that are more likely to have high pollutant concentrations. This would in return prevent overlooking highly contaminated spots which may be located far away from contamination sources. Moreover, these areas can be determined using a smaller number of samples which would decrease the sampling costs. JF - International Journal of Coal Geology AU - Yenilmez, Firdes AU - Kuter, Nazan AU - Emil, Mustafa Kemal AU - Aksoy, A A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 12 EP - 19 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - electrical conductivity KW - Cankiri Turkey KW - ArcGIS KW - regulations KW - environmental analysis KW - environmental effects KW - Ovacik-Yaprakli Site KW - geographic information systems KW - transport KW - trace elements KW - Asia KW - pH KW - Middle East KW - heavy metals KW - abandoned mines KW - soils KW - mines KW - mine waste KW - waste rock KW - pollutants KW - coal mines KW - Turkey KW - pollution KW - case studies KW - runoff KW - information systems KW - trace metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881451541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Evaluation+of+pollution+levels+at+an+abandoned+coal+mine+site+in+Turkey+with+the+aid+of+GIS&rft.au=Yenilmez%2C+Firdes%3BKuter%2C+Nazan%3BEmil%2C+Mustafa+Kemal%3BAksoy%2C+A&rft.aulast=Yenilmez&rft.aufirst=Firdes&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.11.012 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - abandoned mines; ArcGIS; Asia; Cankiri Turkey; case studies; coal mines; electrical conductivity; environmental analysis; environmental effects; geographic information systems; heavy metals; information systems; Middle East; mine waste; mines; Ovacik-Yaprakli Site; pH; pollutants; pollution; regulations; runoff; soils; trace elements; trace metals; transport; Turkey; waste rock DO - http://dx.doi.org/10.1016/j.coal.2010.11.012 ER - TY - JOUR T1 - Surface coal mine area monitoring using multi-temporal high-resolution satellite imagery AN - 881451534; 2011-062529 AB - Surface mining activities, exploitation of ore and stripping and dumping overburden, cause changes on the land cover and land use of the mine area. Sustainable mining requires continuous monitoring of these changes to identify the long-term impacts of mining on environment and land cover to provide essential safety measures. In this sense, digital image classification provides a powerful tool to obtain a rigorous data and hence diminishes the essence of time-consuming and costly field measurements. There are various image classification techniques, serving different features for different purposes, and the Support Vector Machine (SVM) classification method based on statistical machine learning theory stands out to be an effective and accurate image classification technique among them. This research study investigates the use of SVM classification methods for identifying, quantifying, and analyzing the spatial response of landscape due to surface mining activities in Goynuk open cast mine, Turkey, from year 2004 to 2008. The research algorithm essentially entails (i) acquiring data, (ii) pre-processing the data, (iii) performing image classification, (iv) accuracy assessment and change detection, and (v) analysis of results. The results showed that SVM classification method can effectively be utilized for high spatial resolution multispectral satellite images for identifying the changes in surface coal mine area. JF - International Journal of Coal Geology AU - Demirel, Nuray AU - Emil, Mustafa Kemal AU - Duzgun, H Sebnem A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 3 EP - 11 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - digital data KW - imagery KW - reclamation KW - Goynuk Mine KW - environmental effects KW - support vector machines KW - open-pit mining KW - algorithms KW - Asia KW - multispectral scanner KW - Middle East KW - mines KW - high-resolution methods KW - monitoring KW - surface mining KW - learning theory KW - coal mines KW - Turkey KW - space photography KW - satellite methods KW - planning KW - classification KW - land use KW - image analysis KW - remote sensing KW - 20:Applied geophysics KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881451534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Surface+coal+mine+area+monitoring+using+multi-temporal+high-resolution+satellite+imagery&rft.au=Demirel%2C+Nuray%3BEmil%2C+Mustafa+Kemal%3BDuzgun%2C+H+Sebnem&rft.aulast=Demirel&rft.aufirst=Nuray&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.11.010 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 29 N1 - Document feature - illus. incl. 6 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - algorithms; Asia; classification; coal mines; digital data; environmental effects; Goynuk Mine; high-resolution methods; image analysis; imagery; land use; learning theory; Middle East; mines; mining; monitoring; multispectral scanner; open-pit mining; planning; reclamation; remote sensing; satellite methods; space photography; support vector machines; surface mining; Turkey DO - http://dx.doi.org/10.1016/j.coal.2010.11.010 ER - TY - JOUR T1 - Applications of remote sensing and GIS for monitoring of coal fires, mine subsidence, environmental impacts of coal-mine closure and reclamation AN - 881451526; 2011-062528 JF - International Journal of Coal Geology A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 119 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - mines KW - monitoring KW - geologic hazards KW - reclamation KW - coal mines KW - land subsidence KW - environmental effects KW - geographic information systems KW - natural hazards KW - information systems KW - applications KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881451526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2011-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Applications+of+remote+sensing+and+GIS+for+monitoring+of+coal+fires%2C+mine+subsidence%2C+environmental+impacts+of+coal-mine+closure+and+reclamation&rft.title=Applications+of+remote+sensing+and+GIS+for+monitoring+of+coal+fires%2C+mine+subsidence%2C+environmental+impacts+of+coal-mine+closure+and+reclamation&rft.issn=01665162&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Document feature - illus. N1 - SuppNotes - Individual papers are cited separately N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - applications; coal mines; environmental effects; geographic information systems; geologic hazards; information systems; land subsidence; mines; mining; monitoring; natural hazards; reclamation; remote sensing ER - TY - JOUR T1 - Comparison of methods to estimate the rate of CO (sub 2) emissions and coal consumption from a coal fire near Durango, CO AN - 881448953; 2011-062539 AB - Subsurface fires in coal beds consume coal resources and contribute to the global emissions of CO (sub 2) and air pollutants. Many of these fires are found in China, India, Indonesia, and the United States. Combustion product gases at these coal fires exit through surface fissures that form over fires. These fissures are created when subsurface subsidence causes preexisting fractures in the area to widen. Fissures act as both inlets for air and exhaust for combustion gases. While remote sensing approaches have been used to quantify the rate of coal consumption and CO (sub 2) emissions at large scale fires that extend over large distances, methods for estimating the coal consumption and CO (sub 2) emissions values based on surface observations are less well established. In this paper, a coal fire near Durango, CO, is described. A combination of fissure mapping, thermocouple temperatures, and a cesium-vapor magnetometer survey was used to delineate the aerial extent of the current combustion zone and previously burned zones. Three methods were then used to estimate combustion rates at an active region at the site. In the first method, time-lapse, high-resolution topographic surveys were used to relate surface volumetric losses over the active region to coal consumption and rates of CO (sub 2) emission. In the second method, measured temperatures, gas compositions, and dimensions of an exhaust fissure were used in a simple natural convection chimney model to estimate rate values. The third method estimated coal consumption and CO (sub 2) emission rates by measuring the velocity of exhaust gases, gas compositions and exhaust fissure dimensions. For the second and third methods, (super 13) C isotope signatures were used to determine the fractions of CO (sub 2) that were emitted from coal and CH (sub 4) combustion or from CO (sub 2) in the native gas in the coal seam. A flux accumulation chamber was also used to quantify CO (sub 2) leakage rates from non-fissured regions over an active fire region. The three methods produced roughly consistent estimates of coal combustion and CO (sub 2) emission rates. JF - International Journal of Coal Geology AU - Ide, S Taku AU - Orr, F M, Jr A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 95 EP - 107 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - United States KW - La Plata County Colorado KW - geologic hazards KW - isotopes KW - isotope ratios KW - C-13/C-12 KW - land subsidence KW - coal seams KW - convection KW - combustion KW - magnetometers KW - stable isotopes KW - temperature KW - measurement KW - carbon dioxide KW - fires KW - sedimentary rocks KW - Durango Colorado KW - coal KW - carbon KW - natural hazards KW - San Juan Basin KW - Colorado KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Comparison+of+methods+to+estimate+the+rate+of+CO+%28sub+2%29+emissions+and+coal+consumption+from+a+coal+fire+near+Durango%2C+CO&rft.au=Ide%2C+S+Taku%3BOrr%2C+F+M%2C+Jr&rft.aulast=Ide&rft.aufirst=S&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.005 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 30 N1 - Document feature - illus. incl. 4 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - C-13/C-12; carbon; carbon dioxide; coal; coal seams; Colorado; combustion; convection; Durango Colorado; fires; geologic hazards; isotope ratios; isotopes; La Plata County Colorado; land subsidence; magnetometers; measurement; natural hazards; San Juan Basin; sedimentary rocks; stable isotopes; temperature; United States DO - http://dx.doi.org/10.1016/j.coal.2010.12.005 ER - TY - JOUR T1 - Risk assessment of underground coal fire development at regional scale AN - 881448949; 2011-062538 AB - Underground coal combustion is a phenomenon known worldwide. Coal fire monitoring and risk assessment provide important input data for the delineation of coal fire zones and planning of extinguishing activities. At present, research on coal fire risk focuses mainly on the probability assessment of spontaneous combustion at micro scale, based on laboratory investigations of coal molecular structure and composition, and their impact on the combustion process. Coal fire risk assessment at a larger scale, such as for mines, relies on geological factors and aspects of mining engineering and mine management. These scales, however, are insufficient when considering extinguishing activities in larger areas. In order to fill these gaps, we studied risk assessment of underground coal fire development (UCFD) at a regional scale. The factors impacting on coal fire development were analyzed under three different aspects: coal composition and structure which can influence the direction of underground coal combustion; topography and geology which determine the burning environment; and climatic conditions and human activities which trigger combustion processes. Based on this analysis, a regional underground coal fire risk assessment (UCF-RA) index system was established; it is predicated on the assumption that all indices contribute equally to coal fire risk. Data layers of 1 km x 1 km spatial resolution for each index were calculated and overlaid. Xinjiang Uygur Autonomous Region was selected as a validation area. In view of local conditions and the availability of relevant data, the index system was modified; the applied method, however, remained unchanged. Assessment results are generally satisfying and can be used for monitoring and extinguishing of underground coal fires (UCFs) in Xinjiang. JF - International Journal of Coal Geology AU - Wu, Jianjun AU - Liu, Xiaochen A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 87 EP - 94 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - methods KW - monitoring KW - Far East KW - Xinjiang Uyghur Autonomous Region KW - geologic hazards KW - Xinjiang China KW - combustion KW - coal fields KW - fires KW - sedimentary rocks KW - regional KW - coal KW - natural hazards KW - risk assessment KW - Asia KW - China KW - coal deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Risk+assessment+of+underground+coal+fire+development+at+regional+scale&rft.au=Wu%2C+Jianjun%3BLiu%2C+Xiaochen&rft.aulast=Wu&rft.aufirst=Jianjun&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 46 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; China; coal; coal deposits; coal fields; combustion; Far East; fires; geologic hazards; methods; monitoring; natural hazards; regional; risk assessment; sedimentary rocks; Xinjiang China; Xinjiang Uyghur Autonomous Region DO - http://dx.doi.org/10.1016/j.coal.2010.12.007 ER - TY - JOUR T1 - A remote sensing and GIS-based investigation of a boreal forest coal fire AN - 881448943; 2011-062537 AB - A coal seam fire in interior Alaska was suspected to have started the Rex Creek forest fire in the summer of 2009. With prevailing winds, the forest fire spread rapidly to the north and within eleven days it burned about 410 km (super 2) of boreal forest. Coal seam fires can go unnoticed and unreported when present in remote and inaccessible areas. However, they still pose a serious threat to the surroundings. We used summer-time thermal infrared images from 1999 through 2009 acquired by the Landsat satellite and, through the process of image stacking, identified a region where the surface persistently showed temperatures 5 degrees C to 14 degrees C higher than the background areas. Field validation confirmed that this thermal anomaly area corresponds to a previously undocumented shallow coal seam fire. Superimposing the boundary of the Rex Creek forest fire revealed that the coal seam fire was at the southern end of the burn area where the forest fire originated. Plotting the location of all lightning strikes during this period helped to rule out lightning as the cause of the forest fire. Coal fires and forest fires can have a complex and dynamic relationship, one being the possible cause of the other. A thorough inventory of all past and present known coal seam fire locations can help to update forest fire hazard maps. A detailed map of shallow coal seam areas can help to prioritize fire fighting operations in order to avoid the chance of starting a new coal seam fire. JF - International Journal of Coal Geology AU - Prakash, A AU - Schaefer, Kate AU - Witte, William K AU - Collins, K AU - Gens, R AU - Goyette, Michael P A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 79 EP - 86 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - United States KW - forests KW - imagery KW - terrestrial environment KW - geologic hazards KW - coal seams KW - combustion KW - satellite methods KW - boreal environment KW - fires KW - Rex Creek KW - Landsat KW - sedimentary rocks KW - geographic information systems KW - thermal anomalies KW - coal KW - natural hazards KW - information systems KW - Alaska KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=A+remote+sensing+and+GIS-based+investigation+of+a+boreal+forest+coal+fire&rft.au=Prakash%2C+A%3BSchaefer%2C+Kate%3BWitte%2C+William+K%3BCollins%2C+K%3BGens%2C+R%3BGoyette%2C+Michael+P&rft.aulast=Prakash&rft.aufirst=A&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.001 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 46 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Alaska; boreal environment; coal; coal seams; combustion; fires; forests; geographic information systems; geologic hazards; imagery; information systems; Landsat; natural hazards; remote sensing; Rex Creek; satellite methods; sedimentary rocks; terrestrial environment; thermal anomalies; United States DO - http://dx.doi.org/10.1016/j.coal.2010.12.001 ER - TY - JOUR T1 - Detection of coal mine fire in Jharia coal field using Landsat-7 ETM+ data AN - 881448937; 2011-062536 AB - Coal mine fire is a major problem in Jharia Coal Field (JCF). The surface and subsurface mine fire areas can be detected with different type of techniques like borehole temperature measurement, geophysical methods, thermo-compositional analysis, thermo-graphic measurement, airborne remote sensing and space-borne remote sensing techniques. Of these the remote sensing technique is used to detect the coal fires covering a large area using multi-spectral and/or multi-temporal data. In this paper Landsat-7 Enhance Thematic Mapper Plus (ETM+) band 6 thermal data is used for detection of surface and subsurface coal fires. Thermal survey was carried out in the field using thermal imaging camera. The temperatures detected through ETM+ satellite image are validated against those observed field temperature of the study area. This technique is considered as a cost effective for the detection of surface and subsurface temperature profile in comparison to other techniques. JF - International Journal of Coal Geology AU - Mishra, R K AU - Bahuguna, P P AU - Singh, V K A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 73 EP - 78 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - thematic mapper KW - imagery KW - geologic hazards KW - well-logging KW - techniques KW - coal fields KW - India KW - fires KW - sedimentary rocks KW - Indian Peninsula KW - coal KW - spectra KW - temperature logging KW - Asia KW - multispectral scanner KW - mines KW - coal mines KW - thermal analysis KW - Landsat KW - detection KW - boreholes KW - Jharia coal field KW - natural hazards KW - Jharkhand India KW - instruments KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Detection+of+coal+mine+fire+in+Jharia+coal+field+using+Landsat-7+ETM%2B+data&rft.au=Mishra%2C+R+K%3BBahuguna%2C+P+P%3BSingh%2C+V+K&rft.aulast=Mishra&rft.aufirst=R&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.010 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 20 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; boreholes; coal; coal fields; coal mines; detection; fires; geologic hazards; imagery; India; Indian Peninsula; instruments; Jharia coal field; Jharkhand India; Landsat; mines; multispectral scanner; natural hazards; remote sensing; sedimentary rocks; spectra; techniques; temperature logging; thematic mapper; thermal analysis; well-logging DO - http://dx.doi.org/10.1016/j.coal.2010.12.010 ER - TY - JOUR T1 - Integration of ground subsidence hazard maps of abandoned coal mines in Samcheok, Korea AN - 881448934; 2011-062535 AB - Integrated techniques were developed, applied, and validated for the analysis of ground subsidence hazards by abandoned coal mines in Samcheok, Korea, using a geographic information system (GIS). Slope, depth of drift, distance from drift, groundwater level, permeability, geology, and land use were extracted or calculated from the digital elevation model, topographic, drift distribution, borehole, geologic, and land use database. By using the constructed spatial database, the relations between the ground subsidence location and seven related factors were identified and quantified by frequency ratio (FR), weights-of-evidence (WOE), logistic regression (LR), and artificial neural network (ANN) models. The relations were used as factor ratings in the overlay analysis to create ground subsidence hazard indices and maps. The four ground subsidence hazard maps were reflected as the new input factors and integrated using FR, WOE, LR, and ANN models to make a hazard map. All of the subsidence hazard maps were validated by comparison with known ground subsidence locations that were not used in the analysis. As a result, the integrated ground subsidence hazard maps used four new subsidence-related input factors that showed a greater accuracy (96.46% for FR, 97.22% for WOE, 97.20% for LR, and 96.70% for ANN, respectively), than the individual ground subsidence maps (95.54% for FR, 94.22% for WOE, 96.89% for LR, and 94.45% for ANN, respectively) using the first seven factors. JF - International Journal of Coal Geology AU - Oh, Hyun-Joo AU - Lee, S A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 58 EP - 72 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - digital data KW - Far East KW - geologic hazards KW - spatial data KW - data processing KW - mapping KW - land subsidence KW - digital terrain models KW - ground water KW - geographic information systems KW - Samcheok South Korea KW - data bases KW - neural networks KW - Asia KW - abandoned mines KW - mines KW - statistical analysis KW - coal mines KW - Korea KW - artificial intelligence KW - mathematical methods KW - natural hazards KW - risk assessment KW - information systems KW - regression analysis KW - South Korea KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Integration+of+ground+subsidence+hazard+maps+of+abandoned+coal+mines+in+Samcheok%2C+Korea&rft.au=Oh%2C+Hyun-Joo%3BLee%2C+S&rft.aulast=Oh&rft.aufirst=Hyun-Joo&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.11.009 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 46 N1 - Document feature - illus. incl. 8 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - abandoned mines; artificial intelligence; Asia; coal mines; data bases; data processing; digital data; digital terrain models; Far East; geographic information systems; geologic hazards; ground water; information systems; Korea; land subsidence; mapping; mathematical methods; mines; natural hazards; neural networks; regression analysis; risk assessment; Samcheok South Korea; South Korea; spatial data; statistical analysis DO - http://dx.doi.org/10.1016/j.coal.2010.11.009 ER - TY - JOUR T1 - GIS for combined storage and analysis of data from terrestrial and synthetic aperture radar remote sensing deformation measurements in hard coal mining AN - 881448928; 2011-062534 AB - In this paper we demonstrate the capabilities of our ArcGIS-based software development that includes an adapted database system and a GIS tool for storage, combined analysis and visualization of leveling data and interferometric synthetic aperture radar (SAR) deformation measurements. Preprocessed remote sensing image data are stored with metadata that include all processing routines and parameters. This allows reproduction and traceability of all processing steps. Deformation monitoring is supported through data searching and selection based on a variety of criteria. A methods toolbox allows spatio-temporal analyses for points, lines and areas (e.g. subsidence basins) in a graphical manner. JF - International Journal of Coal Geology AU - Hannemann, W AU - Brock, T AU - Busch, W A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 54 EP - 57 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - mines KW - geologic hazards KW - ArcGIS KW - government agencies KW - data processing KW - coal mines KW - radar methods KW - Europe KW - land subsidence KW - deformation KW - interferometry KW - measurement KW - computer programs KW - visualization KW - geographic information systems KW - SAR KW - Central Europe KW - natural hazards KW - data bases KW - information systems KW - Germany KW - remote sensing KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=GIS+for+combined+storage+and+analysis+of+data+from+terrestrial+and+synthetic+aperture+radar+remote+sensing+deformation+measurements+in+hard+coal+mining&rft.au=Hannemann%2C+W%3BBrock%2C+T%3BBusch%2C+W&rft.aulast=Hannemann&rft.aufirst=W&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.12.011 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 11 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - ArcGIS; Central Europe; coal mines; computer programs; data bases; data processing; deformation; Europe; geographic information systems; geologic hazards; Germany; government agencies; information systems; interferometry; land subsidence; measurement; mines; mining; natural hazards; radar methods; remote sensing; SAR; visualization DO - http://dx.doi.org/10.1016/j.coal.2010.12.011 ER - TY - JOUR T1 - Monitoring of hydrochemical parameters of lignite mining lakes in central Germany using airborne hyperspectral casi-scanner data AN - 881448922; 2011-062533 AB - Active and abandoned coal mines have a huge impact on the environment. The most challenging problem is caused by acid mine drainage (AMD). Using traditional methods such as single point measurements to determine and analyze mining lakes over the period of a few years is difficult due to the lakes' high dynamic and inner differentiation. To overcome this difficulty, a new method has been successfully tested to additionally monitor residual lakes. Using a manifold data set (like images from the hyperspectral airborne scanner casi, ground truth data, spectral field and laboratory measurements), the optical properties (reflection, absorption and scattering) of acid mining lakes were defined for the first time ever. Furthermore, hydrochemical parameters in quality and quantity were ascertained in a two-stage process. First, optical properties of the mining lakes were analyzed and defined for each of the limnological stages of development. Second, based on the lakes' optical properties, algorithms for classification of the hydrochemical parameters evolved and were reliably utilized. The new algorithms enable the monitoring of mining lakes from acidic to alkaline as well as the quantification of the hydrochemical properties inside the lake water. JF - International Journal of Coal Geology AU - Glaesser, Cornelia AU - Groth, Doreen AU - Frauendorf, Judith A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 40 EP - 53 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - mining KW - hyperspectral analysis KW - imagery KW - hyperspectral scanner KW - lakes KW - Europe KW - environmental analysis KW - environmental effects KW - Saxony-Anhalt Germany KW - sedimentary rocks KW - coal KW - Central Europe KW - lignite KW - multispectral scanner KW - geochemistry KW - water quality monitoring KW - hydrology KW - mines KW - surface water KW - coal mines KW - pollution KW - Bitterfeld Germany KW - satellite methods KW - hydrochemistry KW - limnology KW - Germany KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Monitoring+of+hydrochemical+parameters+of+lignite+mining+lakes+in+central+Germany+using+airborne+hyperspectral+casi-scanner+data&rft.au=Glaesser%2C+Cornelia%3BGroth%2C+Doreen%3BFrauendorf%2C+Judith&rft.aulast=Glaesser&rft.aufirst=Cornelia&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.01.007 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 47 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Bitterfeld Germany; Central Europe; coal; coal mines; environmental analysis; environmental effects; Europe; geochemistry; Germany; hydrochemistry; hydrology; hyperspectral analysis; hyperspectral scanner; imagery; lakes; lignite; limnology; mines; mining; multispectral scanner; pollution; remote sensing; satellite methods; Saxony-Anhalt Germany; sedimentary rocks; surface water; water quality monitoring DO - http://dx.doi.org/10.1016/j.coal.2011.01.007 ER - TY - JOUR T1 - Analyses and monitoring of lignite mining lakes in eastern Germany with spectral signatures of Landsat TM satellite data AN - 881448913; 2011-062532 AB - Coal mining activities cause an increased acidity and an associated decrease of the pH-value in mine waters. This process is also known as acid mine drainage (AMD). Due to AMD, lakes that were formed in the post mining landscapes in the lignite mining area of Central Germany are characterized by specific limnological development changes. Remote sensing is a time and cost saving technique that enables the observation of the hydrological and limnological development of the lakes ranging from a small to a mid size scale. The current research was based on Landsat TM5/ETM+7 satellite data collected between 1999 and 2004. In combination of satellite data, surface waters of the post mining lakes in Central Germany were sampled and analyzed for their physicochemical properties. The objective of this approach was to evaluate the environmental conditions and to develop a monitoring system. On the other hand, the research was conducted to assess the potential of the use of satellite data and to calibrate its content for monitoring the geochemistry of mining lakes. Correlation of hydrochemical parameters of lake water to spectral signatures detected by satellites was performed with multivariate statistical analysis methods. The five determined clusters of spectral partitions described the actual data (ground truth data) within the visible range. The statistically identified clusters were combined with expert knowledge in limnology, geology and water chemistry of large scale lakes in open cast mining areas, in order to analyze the spectral information of the satellite images scientifically. The utilization of spectral signatures revealed an acceptable classification of hydrological and hydrochemical properties of mining lakes and established the basis for further investigation of open cast lignite mining concerning the environmental impact, particularly in areas where lignite mining lakes usually form. JF - International Journal of Coal Geology AU - Schroeter, Luise AU - Glaesser, Cornelia A2 - Karacan, C. Ozgen A2 - Duzgun, Sebnem H. A2 - Kuenzer, Claudia Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 27 EP - 39 PB - Elsevier, Amsterdam VL - 86 IS - 1 SN - 0166-5162, 0166-5162 KW - water quality KW - thematic mapper KW - lakes KW - Europe KW - environmental analysis KW - environmental effects KW - Saxony-Anhalt Germany KW - sedimentary rocks KW - coal KW - Central Europe KW - lignite KW - spectra KW - water pollution KW - geochemistry KW - hydrology KW - mines KW - monitoring KW - acid mine drainage KW - coal mines KW - pollution KW - Bitterfeld Germany KW - satellite methods KW - hydrochemistry KW - limnology KW - Landsat KW - Germany KW - remote sensing KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881448913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Analyses+and+monitoring+of+lignite+mining+lakes+in+eastern+Germany+with+spectral+signatures+of+Landsat+TM+satellite+data&rft.au=Schroeter%2C+Luise%3BGlaesser%2C+Cornelia&rft.aulast=Schroeter&rft.aufirst=Luise&rft.date=2011-04-01&rft.volume=86&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.01.005 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 69 N1 - Document feature - illus. incl. 10 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acid mine drainage; Bitterfeld Germany; Central Europe; coal; coal mines; environmental analysis; environmental effects; Europe; geochemistry; Germany; hydrochemistry; hydrology; lakes; Landsat; lignite; limnology; mines; monitoring; pollution; remote sensing; satellite methods; Saxony-Anhalt Germany; sedimentary rocks; spectra; thematic mapper; water pollution; water quality DO - http://dx.doi.org/10.1016/j.coal.2011.01.005 ER - TY - RPRT T1 - Table of contents AN - 878683346 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-04-01&rft.volume=&rft.issue=561&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRALIN (CAS NO. 119-64-2) IN F344/N RATS AND B6C3F1 MICE AND A TOXICOLOGY STUDY OF TETRALIN IN MALE NBR RATS (INHALATION STUDIES) AN - 878680827; 21685956 AB - Tetralin is widely used as a solvent for naphthalene, waxes, resins, oils, fats, polishes, and cleaning products. We studied tetralin to determine if it caused cancer in rats or mice. We exposed groups of 50 male and female rats and mice to air containing 30, 60, or 120 parts per million (ppm) tetralin six hours per day for two years. Similar groups of 50 animals were exposed to clean air in the same inhalation chambers six hours per day as the untreated control groups. Tissues from more than 40 sites were examined for every animal. Survival and body weights of rats and mice were not adversely affected by exposure to tetralin. Male rats exposed to tetralin had higher rates of tumors of the kidney, and female rats exposed to decalin had increased rates of rare tumors in the liver and polyps in the uterus. There were also slightly increased rates of testicular tumors in male rats and hemangiosarcomas of the spleen in female mice. In all groups of male and female rats and mice exposed to tetralin by inhalation there was extensive hyperplasia and metaplasia of the epithelium of the nose. All male and female mice exposed to tetralin had granules in the urinary bladder. We conclude that tetralin caused cancer of the kidney in male rats and of the liver and uterus in female rats. Increases in testicular tumors in male rats and hemangiosarcomas of the spleen in female mice may have been related to exposure to tetralin. There was no evidence that tetralin increased tumor rates in male mice. Noncancerous lesions in the nose in all groups of exposed animals and of the urinary bladder in all exposed mice were attributed to exposure to tetralin. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1 EP - 198 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Tetrahydronaphthalenes KW - tetralin KW - Toxicology KW - Rodents KW - Solvents KW - Carcinogens KW - Cancer KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Administration, Inhalation KW - Tetrahydronaphthalenes -- administration & dosage KW - Male KW - Female KW - Neoplasms -- chemically induced KW - Tetrahydronaphthalenes -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878680827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+TETRALIN+%28CAS+NO.+119-64-2%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+AND+A+TOXICOLOGY+STUDY+OF+TETRALIN+IN+MALE+NBR+RATS+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-04-01&rft.volume=&rft.issue=561&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2011 N1 - Document feature - Tables; Graphs; References; Photographs N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878680777 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878680777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-04-01&rft.volume=&rft.issue=561&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2011 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Mortality of US pentachlorophenol production workers through 2005 AN - 876225623; 14880738 AB - A cohort of 2122 US pentachlorophenol (PCP) production workers from four plants in the National Institute for Occupational Safety and Health Dioxin Registry was exposed to PCP and to polychlorinated dibenzo-p-dioxin and dibenzofuran contaminants of PCP production. A subcohort of 720 was also exposed to 2,3,7,8-tetrachlorodibenzodioxin, a contaminant of trichlorophenol (TCP) while using TCP or a TCP derivative. PCP and several production contaminants have been implicated as animal carcinogens. A priori hypotheses were that the cohort would have elevated standardized mortality ratios (SMRs) for aplastic anemia, soft-tissue sarcoma, and non-Hodgkin lymphoma, as suggested by human studies, and for leukemia and liver, adrenal, thyroid, and parathyroid cancer, as suggested by animal studies. From 1940 to 2005 1165 deaths occurred with an overall SMR of 1.01 [95% confidence limits (CI), 0.95-1.07]. Overall cancer mortality (326 deaths, SMR 1.17, CI 1.05-1.31) was in statistically significant excess. There were excess deaths for trachea, bronchus and lung cancers (126 deaths, SMR 1.36, CI 1.13-1.62), non-Hodgkin lymphoma (17 deaths, SMR 1.77, CI 1.03-2.84), chronic obstructive pulmonary disease (63 deaths, SMR 1.38, CI 1.06-1.77), and medical complications (5 deaths, SMR 3.52, CI 1.14-8.22). In race- and sex-specific analyses, white males had increased non-Hodgkin lymphoma mortality (17 deaths, SMR 1.98, CI 1.15-3.17) and males of other races had increased leukemia mortality (four deaths, SMR 4.57, CI 1.25-11.7). The excess of cancers of a priori interest, non-Hodgkin lymphoma and leukemia, provide some support for the carcinogenicity of PCP, however, further studies with more detailed exposure assessment are needed. JF - Chemosphere AU - Ruder, Avima M AU - Yiin, James H AD - National Institute for Occupational Safety and Health, CDC, Cincinnati, OH 45226, USA Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 851 EP - 861 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 83 IS - 6 SN - 0045-6535, 0045-6535 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Pentachlorophenol KW - Cohort mortality KW - Occupational exposure KW - Cancer KW - Non-Hodgkin lymphoma KW - non-Hodgkin's lymphoma KW - Mortality KW - Leukemia KW - USA KW - Carcinogenicity KW - pentachlorophenol KW - Carcinogens KW - Lung cancer KW - chronic obstructive pulmonary disease KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876225623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Mortality+of+US+pentachlorophenol+production+workers+through+2005&rft.au=Ruder%2C+Avima+M%3BYiin%2C+James+H&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2011-04-01&rft.volume=83&rft.issue=6&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2011.02.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - non-Hodgkin's lymphoma; Leukemia; Mortality; Carcinogenicity; pentachlorophenol; Carcinogens; Occupational exposure; Cancer; chronic obstructive pulmonary disease; Lung cancer; USA DO - http://dx.doi.org/10.1016/j.chemosphere.2011.02.064 ER - TY - JOUR T1 - Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs AN - 872131966; 14604104 AB - The safe disposal of unused opioid drugs is an area of regulatory concern. While toilet flushing is recommended for some drugs to prevent accidental exposure, there is a need for data that can support a more consistent disposal policy based on an assessment of relative risk. For drugs acting at the Mu-opioid receptor (MOR), published measurements of binding affinity (K i) are incomplete and inconsistent due to differences in methodology and assay system, leading to a wide range of values for the same drug thus precluding a simple and meaningful relative ranking of drug potency. Experiments were conducted to obtain K i's for 19 approved opioid drugs using a single binding assay in a cell membrane preparation expressing recombinant human MOR. The K i values obtained ranged from 0.1380nM (sufentanil) to 12.486I14M (tramadol). The drugs were separated into three categories based upon their K i values: K i >100nM (tramadol, codeine, meperidine, propoxyphene and pentazocine), K i =1-100nM (hydrocodone, oxycodone, diphenoxylate, alfentanil, methadone, nalbuphine, fentanyl and morphine) and K i <1nM (butorphanol, levorphanol, oxymorphone, hydromorphone, buprenorphine and sufentanil). These data add to the understanding of the pharmacology of opioid drugs and support the development of a more consistent labeling policies regarding safe disposal. JF - Regulatory Toxicology and Pharmacology AU - Volpe, Donna A AU - Tobin, Grainne AMcMahon AU - Mellon, RDaniel AU - Katki, Aspandiar G AU - Parker, Robert J AU - Colatsky, Thomas AU - Kropp, Timothy J AU - Verbois, SLeigh AD - Laboratory of Clinical Pharmacology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 385 EP - 390 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 59 IS - 3 SN - 0273-2300, 0273-2300 KW - Risk Abstracts; Toxicology Abstracts KW - Risk assessment KW - Pharmacology KW - oxycodone KW - sufentanil KW - Buprenorphine KW - pentazocine KW - Cell membranes KW - Drugs KW - Opioid receptors KW - Morphine KW - Membranes KW - Data processing KW - Toilets KW - tramadol KW - Drug development KW - fentanyl KW - Codeine KW - Methadone KW - propoxyphene KW - butorphanol KW - Opioid receptors (type mu) KW - Opioids KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872131966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Uniform+assessment+and+ranking+of+opioid+Mu+receptor+binding+constants+for+selected+opioid+drugs&rft.au=Volpe%2C+Donna+A%3BTobin%2C+Grainne+AMcMahon%3BMellon%2C+RDaniel%3BKatki%2C+Aspandiar+G%3BParker%2C+Robert+J%3BColatsky%2C+Thomas%3BKropp%2C+Timothy+J%3BVerbois%2C+SLeigh&rft.aulast=Volpe&rft.aufirst=Donna&rft.date=2011-04-01&rft.volume=59&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2010.12.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Risk assessment; Opioid receptors; Morphine; Data processing; Toilets; Pharmacology; tramadol; Drug development; sufentanil; fentanyl; oxycodone; Codeine; Methadone; pentazocine; Buprenorphine; propoxyphene; Cell membranes; butorphanol; Opioids; Opioid receptors (type mu); Drugs; Membranes DO - http://dx.doi.org/10.1016/j.yrtph.2010.12.007 ER - TY - JOUR T1 - Awareness and knowledge of methylmercury in fish in the United States AN - 867746789; 14609899 AB - In the 1970s several states in the Great Lakes region became concerned about mercury contamination in lakes and rivers and were the first to issue local fish consumption advisories. In 2001, the Food and Drug Administration (FDA) advised pregnant women, nursing mothers, young children, and women who may become pregnant not to consume shark, swordfish, king mackerel, and tilefish and recommended that these women not exceed 12 ounces of other fish per week. In 2004, FDA reissued this advice jointly with the U.S. Environmental Protection Agency (EPA) and modified it slightly to provide information about consumption of canned tuna and more details about consumption of recreationally caught fish. Though several studies have examined consumers' awareness of the joint FDA and EPA advisory as well as different state advisories, few used representative data. We examined the changes in awareness and knowledge of mercury as a problem in fish using the pooled nationally representative 2001 and 2006 Food Safety Surveys (FSS) with sample sizes of 4482 in 2001 and 2275 in 2006. Our results indicated an increase in consumers' awareness of mercury as a problem in fish (69% in 2001 to 80% in 2006, p<.001). In our regression models, we found that in both years, parents having children less than 5 years of age were more aware of mercury in fish and knowledgeable about the information contained in the national advisories about mercury in fish (p<.01) than other adults. In both 2001 and 2006, women of childbearing age (aged 18-45) were less aware and knowledgeable about this information than other women. However, women of all age groups had larger gains in awareness and knowledge than their male counterparts during this time. Participants' race, education, income, region, fish preparation experiences, having a foodborne illness in the past year, and risk perceptions about the safety of food were significant predictors of their awareness and knowledge. JF - Environmental Research AU - Lando, Amy M AU - Zhang, Yuanting AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA, amy.lando@fda.hhs.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 442 EP - 450 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 111 IS - 3 SN - 0013-9351, 0013-9351 KW - ASFA 1: Biological Sciences & Living Resources; Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Sustainability Science Abstracts KW - Methylmercury KW - National survey KW - Fish consumption KW - Women of childbearing age KW - Thunnus KW - Age KW - Freshwater KW - Freshwater fish KW - Public health KW - Marine fish KW - Lakes KW - Consumers KW - Freshwater pollution KW - Biological surveys KW - Marine KW - Methyl mercury KW - Children KW - Pregnancy KW - EPA KW - USA KW - Perception KW - North America, Great Lakes KW - Scomber KW - FDA KW - Mercury KW - Fish KW - Age groups KW - M3 1010:Issues in Sustainable Development KW - P 2000:FRESHWATER POLLUTION KW - Q1 08422:Environmental effects KW - Q5 08502:Methods and instruments KW - R2 23050:Environment KW - H 4000:Food and Drugs KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867746789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Awareness+and+knowledge+of+methylmercury+in+fish+in+the+United+States&rft.au=Lando%2C+Amy+M%3BZhang%2C+Yuanting&rft.aulast=Lando&rft.aufirst=Amy&rft.date=2011-04-01&rft.volume=111&rft.issue=3&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2011.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Biological surveys; Marine fish; Methyl mercury; Fish consumption; Mercury; Age groups; Consumers; Freshwater fish; Freshwater pollution; Public health; EPA; Age; Lakes; Perception; FDA; Fish; Children; Pregnancy; Thunnus; Scomber; USA; North America, Great Lakes; Marine; Freshwater DO - http://dx.doi.org/10.1016/j.envres.2011.01.004 ER - TY - JOUR T1 - The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures AN - 867741245; 14604107 AB - Humans are simultaneously exposed to multiple chemicals in the environment. Many of the chemicals use the same enzymes in their metabolic pathways. Competitive inhibition may occur as one of the possible interactions between the xenobiotics in human body. For example, many volatile organic compounds (VOCs) are metabolized using P450 enzymes, specifically CYP2E1. Inheritable gene alterations may result in changes of function of the enzymes in different human subpopulations. Variations in quantity and/or quality of particular isoenzymes may cause differences in the metabolism of VOCs. These variations may cause higher sensitivity in certain populations. Using examples of three different mixtures, this review paper outlines the variances in CYP2E1 isoenzymes, effect of exposure to such mixtures on sensitive populations, and approaches to mixtures risk assessment. JF - Regulatory Toxicology and Pharmacology AU - Pohl, Hana R AU - Scinicariello, Franco AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA 30333, USA, hpohl@cdc.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 364 EP - 374 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 59 IS - 3 SN - 0273-2300, 0273-2300 KW - Genetics Abstracts; Environment Abstracts; Pollution Abstracts; Risk Abstracts; Toxicology Abstracts KW - Chemicals KW - Risk assessment KW - Sensitivity KW - Subpopulations KW - Enzymes KW - Xenobiotics KW - subpopulations KW - Reviews KW - Isoenzymes KW - volatile organic compounds KW - Metabolic pathways KW - Volatile organic compounds KW - Metabolism KW - G 07710:Chemical Mutagenesis & Radiation KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=The+impact+of+CYP2E1+genetic+variability+on+risk+assessment+of+VOC+mixtures&rft.au=Pohl%2C+Hana+R%3BScinicariello%2C+Franco&rft.aulast=Pohl&rft.aufirst=Hana&rft.date=2011-04-01&rft.volume=59&rft.issue=3&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2011.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2013-09-20 N1 - SubjectsTermNotLitGenreText - Risk assessment; Subpopulations; Metabolic pathways; volatile organic compounds; Isoenzymes; Enzymes; Xenobiotics; Chemicals; Sensitivity; subpopulations; Reviews; Metabolism; Volatile organic compounds DO - http://dx.doi.org/10.1016/j.yrtph.2011.01.013 ER - TY - JOUR T1 - Surface chemistry of a pine-oil cleaner and other terpene mixtures with ozone on vinyl flooring tiles AN - 864954426; 14525375 AB - Indoor environments are dynamic reactors where consumer products (such as cleaning agents, deodorants, and air fresheners) emit volatile organic compounds (VOCs) that can subsequently interact with indoor oxidants such as ozone (O3), hydroxyl radicals, and nitrate radicals. Typically, consumer products consist of mixtures of VOCs and semi-VOCs which can react in the gas-phase or on surfaces with these oxidants to generate a variety of oxygenated products. In this study, the reaction of a pine-oil cleaner (POC) with O3 (100ppb) on a urethane-coated vinyl flooring tile was investigated at 5% and 50% relative humidity. These results were compared to previous alpha -terpineol+O3 reactions on glass and vinyl surfaces. Additionally, other terpene and terpene alcohol mixtures were formulated to understand the emission profiles as seen in the POC data. Results showed that the alpha -terpineol+O3 reaction products were the prominent species that were also observed in the POC/O3 surface experiments. Furthermore, alpha -terpineol+O3 reactions generate the largest fraction of oxygenated products even in equal mixtures of other terpene alcohols. This finding suggests that the judicial choice of terpene alcohols for inclusion in product formulations may be useful in reducing oxidation product emissions. JF - Chemosphere AU - Ham, Jason E AU - Wells, JRaymond AD - Exposure Assessment Branch, Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, United States, bvo2@cdc.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 327 EP - 333 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 83 IS - 3 SN - 0045-6535, 0045-6535 KW - Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Pine oil KW - Ozone KW - Reaction products KW - Surface chemistry KW - Chemicals KW - Relative humidity KW - Alcohol KW - Ozone measurements KW - Consumer products KW - surface chemistry KW - Terpenes in air KW - Humidity KW - Organic compounds in atmosphere KW - Hydroxyl radicals KW - Volatile organic compound emissions KW - Oxidation KW - Emissions KW - Oxidants KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864954426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Surface+chemistry+of+a+pine-oil+cleaner+and+other+terpene+mixtures+with+ozone+on+vinyl+flooring+tiles&rft.au=Ham%2C+Jason+E%3BWells%2C+JRaymond&rft.aulast=Ham&rft.aufirst=Jason&rft.date=2011-04-01&rft.volume=83&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2010.12.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Relative humidity; Ozone measurements; Oxidation; Volatile organic compound emissions; Terpenes in air; Organic compounds in atmosphere; Ozone; Chemicals; Alcohol; Consumer products; surface chemistry; Emissions; Humidity; Oxidants; Hydroxyl radicals DO - http://dx.doi.org/10.1016/j.chemosphere.2010.12.036 ER - TY - JOUR T1 - A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background. AN - 863899669; 20739907 AB - The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from NAT2 haplotypes based on seven single nucleotide polymorphisms (SNPs) in a study in Spain. In a subsequent genome-wide scan, we have identified a single common tag SNP (rs1495741) located in the 3' end of NAT2 that is also associated with bladder cancer risk. The aim of this report is to evaluate the agreement between the common tag SNP and the 7-SNP NAT2 inferred phenotype. The agreement between the 7-SNP NAT2 inferred phenotype and the tag SNP, rs1495741, was initially assessed in 2174 individuals from the Spanish Bladder Cancer Study (SBCS), and confirmed in a subset of individuals from the Main and Vermont component the New England Bladder Cancer Study (NEBCS). We also investigated the association of rs1495741 genotypes with NAT2 catalytic activity in cryopreserved hepatocytes from 154 individuals of European background. We observed very strong agreement between rs1495741 and the 7-SNP inferred NAT2 phenotype: sensitivity and specificity for the NAT2 slow phenotype was 99 and 95%, respectively. Our findings were replicated in an independent population from the NEBCS. Estimates for the association between NAT2 slow phenotype and bladder cancer risk in the SBCS and its interaction with cigarette smoking were comparable for the 7-SNP inferred NAT2 phenotype and rs1495741. In addition, rs1495741 genotypes were strongly related to NAT2 activity measured in hepatocytes (P<0.0001). A novel NAT2 tag SNP (rs1495741) predicts with high accuracy the 7-SNP inferred NAT2 phenotype, and thus can be used as a sole marker in pharmacogenetic or epidemiological studies of populations of European background. These findings illustrate the utility of tag SNPs, often used in genome-wide association studies (GWAS), to identify novel phenotypic markers. Further studies are required to determine the functional implications of rs1495741 and the structure and evolution of the haplotype on which it resides. JF - Pharmacogenetics and genomics AU - García-Closas, Montserrat AU - Hein, David W AU - Silverman, Debra AU - Malats, Núria AU - Yeager, Meredith AU - Jacobs, Kevin AU - Doll, Mark A AU - Figueroa, Jonine D AU - Baris, Dalsu AU - Schwenn, Molly AU - Kogevinas, Manolis AU - Johnson, Alison AU - Chatterjee, Nilanjan AU - Moore, Lee E AU - Moeller, Timothy AU - Real, Francisco X AU - Chanock, Stephen AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. Montse.GarciaClosas@icr.ac.uk Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 231 EP - 236 VL - 21 IS - 4 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Genotype KW - Haplotypes KW - Spain KW - Humans KW - New England KW - Case-Control Studies KW - European Continental Ancestry Group -- genetics KW - Vermont KW - Phenotype KW - Polymorphism, Single Nucleotide -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863899669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=A+single+nucleotide+polymorphism+tags+variation+in+the+arylamine+N-acetyltransferase+2+phenotype+in+populations+of+European+background.&rft.au=Garc%C3%ADa-Closas%2C+Montserrat%3BHein%2C+David+W%3BSilverman%2C+Debra%3BMalats%2C+N%C3%BAria%3BYeager%2C+Meredith%3BJacobs%2C+Kevin%3BDoll%2C+Mark+A%3BFigueroa%2C+Jonine+D%3BBaris%2C+Dalsu%3BSchwenn%2C+Molly%3BKogevinas%2C+Manolis%3BJohnson%2C+Alison%3BChatterjee%2C+Nilanjan%3BMoore%2C+Lee+E%3BMoeller%2C+Timothy%3BReal%2C+Francisco+X%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel&rft.aulast=Garc%C3%ADa-Closas&rft.aufirst=Montserrat&rft.date=2011-04-01&rft.volume=21&rft.issue=4&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0b013e32833e1b54 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-22 N1 - Date created - 2011-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Carcinogenesis. 2011 Feb;32(2):182-9 [21037224] Pharmacogenetics. 2001 Apr;11(3):207-15 [11337936] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1543-6 [15342459] Pharmacogenetics. 1992 Jun;2(3):116-27 [1306111] Hum Mol Genet. 1994 May;3(5):729-34 [8081359] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Carcinogenesis. 2007 Aug;28(8):1665-71 [17434923] Curr Drug Metab. 2008 Jul;9(6):471-86 [18680467] Expert Opin Drug Metab Toxicol. 2009 Apr;5(4):353-66 [19379125] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] DNA Cell Biol. 2009 Jan;28(1):3-7 [18821846] J Pharmacol Exp Ther. 2010 Aug;334(2):540-4 [20430842] Nat Genet. 2010 Nov;42(11):978-84 [20972438] Anal Biochem. 2001 Jan 1;288(1):106-8 [11141315] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/FPC.0b013e32833e1b54 ER - TY - JOUR T1 - A Comparison of the Thermal-Dose Equation and the Intensity-Time Product, It[super]m, for Predicting Tissue Damage Thresholds AN - 862785355; 14614440 AB - Thermal dose is the most generally accepted concept for estimating temperature-related tissue damage thresholds in high-intensity focused ultrasound (HIFU) procedures. However, another approach based on the intensity-time product I t[super]m = D has been used, where D is a tissue-dependent damage threshold, I is the spatial-peak, temporal-average intensity and t is time. In this study, these two approaches were compared analytically by substituting a well-known soft-tissue solution for temperature vs. time into the thermal dose equation. From power law fits of I vs. t, m was found to fall between about 0.3 and 0.8. In terms of the intensity required for cell death for a given exposure time, the standard deviation of the error between the full thermal-dose formulation and the I t[super]m = D prediction based upon the power-law fit was less than 5% for focal beam diameters up to 3 mm. Thus, for the practical range of HIFU parameters examined, the intensity-time product relationship is equivalent to the thermal dose formulation. (E-mail: gerald.harrisda.hhs.gov) JF - Ultrasound in Medicine & Biology AU - Harris, Gerald R AU - Herman, Bruce A AU - Myers, Matthew R AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA, gerald.harris@fda.hhs.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 580 EP - 586 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 37 IS - 4 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Cell death KW - Mathematical models KW - Standard deviation KW - Temperature effects KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862785355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=A+Comparison+of+the+Thermal-Dose+Equation+and+the+Intensity-Time+Product%2C+It%5Bsuper%5Dm%2C+for+Predicting+Tissue+Damage+Thresholds&rft.au=Harris%2C+Gerald+R%3BHerman%2C+Bruce+A%3BMyers%2C+Matthew+R&rft.aulast=Harris&rft.aufirst=Gerald&rft.date=2011-04-01&rft.volume=37&rft.issue=4&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2011.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cell death; Standard deviation; Mathematical models; Ultrasound DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2011.01.005 ER - TY - JOUR T1 - Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. AN - 859759964; 21233488 AB - Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons over an extended period of time. Mitochondrial damage may lead to PD, and neurotoxins affecting mitochondria are widely used to produce degeneration of the nigrostriatal circuitry. Deletion of the mitochondrial transcription factor A gene (Tfam) in C57BL6 mouse DA neurons leads to a slowly progressing parkinsonian phenotype in which motor impairment is first observed at ~12 wk of age. L-DOPA treatment improves motor dysfunction in these "MitoPark" mice, but this declines when DA neuron loss is more complete. To investigate early neurobiological events potentially contributing to PD, we compared the neurochemical and electrophysiological properties of the nigrostriatal circuit in behaviorally asymptomatic 6- to 8-wk-old MitoPark mice and age-matched control littermates. Release, but not uptake of DA, was impaired in MitoPark mouse striatal brain slices, and nigral DA neurons lacked characteristic pacemaker activity compared with control mice. Also, hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel function was reduced in MitoPark DA neurons, although HCN messenger RNA was unchanged. This study demonstrates altered nigrostriatal function that precedes behavioral parkinsonian symptoms in this genetic PD model. A full understanding of these presymptomatic cellular properties may lead to more effective early treatments of PD. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Good, Cameron H AU - Hoffman, Alexander F AU - Hoffer, Barry J AU - Chefer, Vladimir I AU - Shippenberg, Toni S AU - Bäckman, Cristina M AU - Larsson, Nils-Göran AU - Olson, Lars AU - Gellhaar, Sandra AU - Galter, Dagmar AU - Lupica, Carl R AD - Cellular Neurobiology Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1333 EP - 1344 VL - 25 IS - 4 KW - Cyclic Nucleotide-Gated Cation Channels KW - 0 KW - DNA-Binding Proteins KW - Mitochondrial Proteins KW - Transcription Factors KW - mitochondrial transcription factor A KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Corpus Striatum KW - Dopamine -- metabolism KW - Disease Models, Animal KW - Substantia Nigra KW - Mice KW - Male KW - Female KW - Neurons -- metabolism KW - Cyclic Nucleotide-Gated Cation Channels -- physiology KW - Neurons -- physiology KW - DNA-Binding Proteins -- genetics KW - Mitochondrial Proteins -- genetics KW - Parkinson Disease -- physiopathology KW - Transcription Factors -- genetics KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/859759964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Impaired+nigrostriatal+function+precedes+behavioral+deficits+in+a+genetic+mitochondrial+model+of+Parkinson%27s+disease.&rft.au=Good%2C+Cameron+H%3BHoffman%2C+Alexander+F%3BHoffer%2C+Barry+J%3BChefer%2C+Vladimir+I%3BShippenberg%2C+Toni+S%3BB%C3%A4ckman%2C+Cristina+M%3BLarsson%2C+Nils-G%C3%B6ran%3BOlson%2C+Lars%3BGellhaar%2C+Sandra%3BGalter%2C+Dagmar%3BLupica%2C+Carl+R&rft.aulast=Good&rft.aufirst=Cameron&rft.date=2011-04-01&rft.volume=25&rft.issue=4&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-173625 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-03 N1 - Date created - 2011-04-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2003 Sep 11;39(6):889-909 [12971891] Annu Rev Physiol. 2003;65:453-80 [12471170] Science. 1973 Nov 16;182(4113):717-20 [4752211] J Neurol Sci. 1973 Dec;20(4):415-55 [4272516] J Physiol. 1983 Jul;340:19-45 [6887047] Neuroscience. 1983 Oct;10(2):301-15 [6633863] J Neurochem. 1987 Jun;48(6):1787-93 [3106573] J Neurosci. 1987 Jun;7(6):1648-54 [3110381] Mol Chem Neuropathol. 1989 Jun;10(3):185-200 [2504173] J Neurosci. 1990 Jun;10(6):1847-54 [1693953] Trends Neurosci. 1990 Jul;13(7):290-6 [1695406] Arch Neurol. 1990 Dec;47(12):1290-8 [2123623] Brain Res. 1990 Nov 19;533(2):203-12 [2126975] Lancet. 1991 Jun 1;337(8753):1321-4 [1674304] J Physiol. 1990 Dec;431:291-318 [1712843] J Neurosci Methods. 1991 Dec;40(2-3):139-47 [1800851] Histochemistry. 1992 Aug;98(1):39-49 [1429016] J Physiol. 1993 Mar;462:753-64 [8392580] J Neurosci Methods. 1993 Jul;48(3):225-40 [8412305] J Neurosci Methods. 1993 Jul;48(3):263-76 [8105154] J Neurophysiol. 1994 Mar;71(3):1165-73 [8201410] J Neurosci Methods. 1994 Sep;54(1):75-82 [7815821] Neuroscience. 1994 Dec;63(3):757-64 [7898675] Eur J Neurosci. 1995 Mar 1;7(3):462-9 [7773443] J Neurophysiol. 1995 Dec;74(6):2366-78 [8747199] J Neurophysiol. 1996 Oct;76(4):2262-70 [8899601] J Physiol. 1996 Nov 15;497 ( Pt 1):119-30 [8951716] Brain Res. 1997 Apr 11;753(2):225-34 [9125407] Nat Genet. 1998 Mar;18(3):231-6 [9500544] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4029-34 [9520487] J Neurosci. 1998 Sep 1;18(17):6693-703 [9712641] J Neurosci. 1998 Sep 15;18(18):7084-98 [9736632] Nat Genet. 1999 Jan;21(1):133-7 [9916807] Brain Res Mol Brain Res. 2005 Mar 24;134(1):57-66 [15790530] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10023-8 [16006505] Neurotoxicology. 2005 Oct;26(5):857-68 [15922452] Nat Genet. 2006 May;38(5):518-20 [16604072] Nat Genet. 2006 May;38(5):515-7 [16604074] J Neurosci Methods. 2006 Sep 15;155(2):187-93 [16466808] Genesis. 2006 Aug;44(8):383-90 [16865686] Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30 [17227870] Annu Rev Neurosci. 2007;30:259-88 [17600522] FASEB J. 2008 Jan;22(1):261-75 [17690153] FEBS J. 2008 Apr;275(7):1384-91 [18279376] Mol Pharmacol. 2008 Oct;74(4):933-40 [18599602] Cell Mol Life Sci. 2009 Feb;66(3):470-94 [18953682] J Neurosci. 2009 Feb 11;29(6):1735-42 [19211880] Psychopharmacology (Berl). 2009 May;204(1):1-11 [19099297] Prog Neurobiol. 2010 Feb 9;90(2):146-56 [19925845] Genes Brain Behav. 2010 Mar 1;9(2):173-81 [20002202] Neuron. 2010 Jun 10;66(5):646-61 [20547124] Nature. 2010 Aug 26;466(7310):S8-10 [20739935] Trends Cardiovasc Med. 2002 Jul;12(5):206-12 [12161074] Neuroscience. 2002;114(2):475-92 [12204216] J Neurosci Methods. 2002 Nov 15;121(1):41-52 [12393160] J Neurosci. 2003 Nov 26;23(34):10756-64 [14645467] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-173625 ER - TY - JOUR T1 - Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos? AN - 857811883; 21310169 AB - The production of carbon nanofibers and nanotubes (CNF/CNT) and their composite products is increasing globally. CNF are generating great interest in industrial sectors such as energy production and electronics, where alternative materials may have limited performance or are produced at a much higher cost. However, despite the increasing industrial use of carbon nanofibers, information on their potential adverse health effects is limited. In the current study, we examine the cytotoxic and genotoxic potential of carbon-based nanofibers (Pyrograf®-III) and compare this material with the effects of asbestos fibers (crocidolite) or single-walled carbon nanotubes (SWCNT). The genotoxic effects in the lung fibroblast (V79) cell line were examined using two complementary assays: the comet assay and micronucleus (MN) test. In addition, we utilized fluorescence in situ hybridization to detect the chromatin pan-centromeric signals within the MN indicating their origin by aneugenic (chromosomal malsegregation) or clastogenic (chromosome breakage) mechanisms. Cytotoxicity tests revealed a concentration- and time-dependent loss of V79 cell viability after exposure to all tested materials in the following sequence: asbestos>CNF>SWCNT. Additionally, cellular uptake and generation of oxygen radicals was seen in the murine RAW264.7 macrophages following exposure to CNF or asbestos but not after administration of SWCNT. DNA damage and MN induction were found after exposure to all tested materials with the strongest effect seen for CNF. Finally, we demonstrated that CNF induced predominantly centromere-positive MN in primary human small airway epithelial cells (SAEC) indicating aneugenic events. Further investigations are warranted to elucidate the possible mechanisms involved in CNF-induced genotoxicity. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Kisin, E R AU - Murray, A R AU - Sargent, L AU - Lowry, D AU - Chirila, M AU - Siegrist, K J AU - Schwegler-Berry, D AU - Leonard, S AU - Castranova, V AU - Fadeel, B AU - Kagan, V E AU - Shvedova, A A AD - Pathology and Physiology Research Branch, Health Effects Lab Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2011/04/01/ PY - 2011 DA - 2011 Apr 01 SP - 1 EP - 10 VL - 252 IS - 1 KW - Nanotubes, Carbon KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Animals KW - Cricetulus KW - Mutagenicity Tests -- methods KW - Cells, Cultured KW - Humans KW - Cricetinae KW - Fibroblasts -- drug effects KW - Cell Survival -- genetics KW - Cell Survival -- drug effects KW - Asbestos -- adverse effects KW - Asbestos -- toxicity KW - Nanotubes, Carbon -- toxicity KW - Nanotubes, Carbon -- adverse effects KW - Fibroblasts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857811883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Genotoxicity+of+carbon+nanofibers%3A+are+they+potentially+more+or+less+dangerous+than+carbon+nanotubes+or+asbestos%3F&rft.au=Kisin%2C+E+R%3BMurray%2C+A+R%3BSargent%2C+L%3BLowry%2C+D%3BChirila%2C+M%3BSiegrist%2C+K+J%3BSchwegler-Berry%2C+D%3BLeonard%2C+S%3BCastranova%2C+V%3BFadeel%2C+B%3BKagan%2C+V+E%3BShvedova%2C+A+A&rft.aulast=Kisin&rft.aufirst=E&rft.date=2011-04-01&rft.volume=252&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2011.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-16 N1 - Date created - 2011-03-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2011.02.001 ER - TY - JOUR T1 - Characterization and acceptor preference of a soluble meningococcal group C polysialyltransferase. AN - 857121813; 21278299 AB - Vaccines against Neisseria meningitidis group C are based on its α-2,9-linked polysialic acid capsular polysaccharide. This polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody serves to evade host defense mechanisms. The polysialyltransferase (PST) that forms the group C polysialic acid (NmC PST) is located in the cytoplasmic membrane. Until recently, detailed characterization of bacterial polysialyltransferases has been hampered by a lack of availability of soluble enzyme preparations. We have constructed chimeras of the group C polysialyltransferase that catalyzes the formation α-2,9-polysialic acid as a soluble enzyme. We used site-directed mutagenesis to determine the region of the enzyme necessary for synthesis of the α-2,9 linkage. A chimera of NmB and NmC PSTs containing only amino acids 1 to 107 of the NmB polysialyltransferase catalyzed the synthesis of α-2,8-polysialic acid. The NmC polysialyltransferase requires an exogenous acceptor for catalytic activity. While it requires a minimum of a disialylated oligosaccharide to catalyze transfer, it can form high-molecular-weight α-2,9-polysialic acid in a nonprocessive fashion when initiated with an α-2,8-polysialic acid acceptor. De novo synthesis in vivo requires an endogenous acceptor. We attempted to reconstitute de novo activity of the soluble group C polysialyltransferase with membrane components. We found that an acapsular mutant with a defect in the polysialyltransferase produces outer membrane vesicles containing an acceptor for the α-2,9-polysialyltransferase. This acceptor is an amphipathic molecule and can be elongated to produce polysialic acid that is reactive with group C-specific antibody. JF - Journal of bacteriology AU - Peterson, Dwight C AU - Arakere, Gayathri AU - Vionnet, Justine AU - McCarthy, Pumtiwitt C AU - Vann, Willie F AD - Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Building 29, Room 103, 8800 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 1576 EP - 1582 VL - 193 IS - 7 KW - Antibodies, Bacterial KW - 0 KW - Bacterial Outer Membrane Proteins KW - Receptors, Cell Surface KW - Recombinant Proteins KW - Sialic Acids KW - polysialic acid KW - Sialyltransferases KW - EC 2.4.99.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Bacterial Capsules -- genetics KW - Hydrogen-Ion Concentration KW - Bacterial Outer Membrane Proteins -- genetics KW - Antibodies, Bacterial -- immunology KW - Bacterial Outer Membrane Proteins -- metabolism KW - Bacterial Capsules -- metabolism KW - Sialic Acids -- metabolism KW - Mutation KW - Receptors, Cell Surface -- metabolism KW - Sialyltransferases -- genetics KW - Sialyltransferases -- metabolism KW - Neisseria meningitidis, Serogroup C -- enzymology KW - Neisseria meningitidis, Serogroup C -- genetics KW - Gene Expression Regulation, Enzymologic -- physiology KW - Gene Expression Regulation, Bacterial -- physiology KW - Receptors, Cell Surface -- genetics KW - Neisseria meningitidis, Serogroup C -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/857121813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Characterization+and+acceptor+preference+of+a+soluble+meningococcal+group+C+polysialyltransferase.&rft.au=Peterson%2C+Dwight+C%3BArakere%2C+Gayathri%3BVionnet%2C+Justine%3BMcCarthy%2C+Pumtiwitt+C%3BVann%2C+Willie+F&rft.aulast=Peterson&rft.aufirst=Dwight&rft.date=2011-04-01&rft.volume=193&rft.issue=7&rft.spage=1576&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.00924-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-23 N1 - Date created - 2011-03-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Glycobiology. 2001 Aug;11(8):613-20 [11479272] Mol Microbiol. 2010 Sep;77(5):1326-40 [20662776] J Biol Chem. 2003 Apr 25;278(17):15349-59 [12578835] J Mol Microbiol Biotechnol. 2003;5(2):82-6 [12736530] Infect Immun. 2004 Jun;72(6):3451-60 [15155652] Biochem J. 2004 Oct 1;383(Pt 1):83-9 [15200387] Nature. 1981 Feb 19;289(5799):696-8 [7007894] Infect Immun. 1982 Jul;37(1):271-80 [6809629] Infect Immun. 1983 Jul;41(1):54-60 [6408005] Proc Natl Acad Sci U S A. 1989 Mar;86(5):1669-73 [2493648] Mol Microbiol. 1990 Apr;4(4):603-11 [2161990] J Bacteriol. 1992 Feb;174(4):1099-108 [1735705] Glycobiology. 1992 Feb;2(1):5-23 [1550990] J Bacteriol. 1992 Aug;174(15):5127-31 [1629170] Biotechniques. 1992 Aug;13(2):214-20 [1327007] J Bacteriol. 1994 Feb;176(3):691-5 [8300524] JAMA. 1995 Feb 1;273(5):383-9 [7823383] J Bacteriol. 1996 Jul;178(14):4052-9 [8763931] Annu Rev Microbiol. 1996;50:285-315 [8905082] Mol Gen Genet. 1997 Dec;257(1):28-34 [9439566] Infect Immun. 1998 Dec;66(12):5939-47 [9826376] Mol Microbiol. 1999 Mar;31(5):1307-19 [10200953] J Bacteriol. 2006 Mar;188(5):1786-97 [16484189] Vaccine. 2006 May 29;24(22):4692-700 [16621189] Methods Mol Biol. 2007;356:195-208 [16988404] Biochemistry. 2006 Nov 14;45(45):13511-6 [17087504] Glycobiology. 2007 Jul;17(7):735-43 [17384120] Mol Microbiol. 2007 Sep;65(5):1258-75 [17662040] Glycobiology. 2008 Feb;18(2):177-86 [18000029] Mol Microbiol. 2008 Jun;68(5):1252-67 [18435708] Nat Rev Drug Discov. 2010 Apr;9(4):308-24 [20357803] N Engl J Med. 2010 Apr 22;362(16):1511-20 [20410516] J Mol Biol. 2003 Apr 25;328(2):307-17 [12691742] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.00924-10 ER - TY - JOUR T1 - Dynamic oversight: implementation gaps and challenges AN - 1439756765; 18523884 AB - Nanotechnology is touted as a transformative technology in that it is predicted to improve many aspects of human life. There are hundreds of products in the market that utilize nanostructures in their design, such as composite materials made out of carbon or metal oxides. Potential risks to consumers, to the environment, and to workers from the most common passive nanomaterial-carbon nanotubes-are emerging through scientific research. Newer more active nanostructures-such as cancer therapies and targeted drug systems-are also increasing in use and are raising similar risk concerns. Governing the risks to workers is the subject of this commentary. The Occupational Safety and Health Act of 1970 grants the Occupational Safety and Health Administration the legal authority to set occupational health standards to insure that no worker suffers material impairment of health from work. However, setting a standard to protect workers from nanotechnology risks may occur some time in the future because the risks to workers have not been well characterized scientifically. Alternative risk governances-such as dynamic oversight through stakeholder partnerships, "soft law" approaches, and national adoption of international consensus standards-are evaluated in this article. JF - Journal of Nanoparticle Research AU - Howard, John AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Washington, DC, 20201, USA, jhoward1@cdc.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 1427 EP - 1434 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 13 IS - 4 SN - 1388-0764, 1388-0764 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Metals KW - Stakeholders KW - Health risks KW - Composite materials KW - Occupational safety KW - Cancer KW - Nanotechnology KW - Occupational health KW - Technology KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439756765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanoparticle+Research&rft.atitle=Dynamic+oversight%3A+implementation+gaps+and+challenges&rft.au=Howard%2C+John&rft.aulast=Howard&rft.aufirst=John&rft.date=2011-04-01&rft.volume=13&rft.issue=4&rft.spage=1427&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanoparticle+Research&rft.issn=13880764&rft_id=info:doi/10.1007%2Fs11051-011-0225-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Composite materials; Health risks; Stakeholders; Metals; Occupational safety; Cancer; Technology; Occupational health; Nanotechnology DO - http://dx.doi.org/10.1007/s11051-011-0225-2 ER - TY - JOUR T1 - A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method AN - 1323800175; 15715388 AB - The commercial success of synthetic phosphodiesterase-5 (PDE-5) inhibitors (viz. sildenafil, vardenafil and tadalafil) for erectile dysfunction (ED) has led to their widespread use as adulterants in dietary supplements (DSs). Reports on adulteration by ED drugs or their analogues in DSs suggest they may cause a serious threat to human health. The problem is becoming more complex as hidden and structurally modified analogues are continuously being reported. To analyse known drugs and their analogues, three commonly used PDE-5 inhibitors, naturally existing icariin and yohimbin, and their 19 analogues were analyzed in this study. They were identified using ion-spray liquid chromatography/tandem mass spectrometry (LC/MS/MS) using multiple reaction monitoring (MRM). This MRM procedure gave a limit of detection of less than 0.02 ng ml-1 for the 24 compounds, selectivity of fragmentation using MRM for 2.5 - 8.5 min in a single run and peak height repeatability of coefficient of variation of 3.9 - 31.8%. An IDA method using the MRM scans to detect the presence of known analytes was set up and added to a built-in library for screening for PDE-5 inhibitors. These MRM experiments were used to trigger product ion scans using a hybrid quadrupole-linear ion trap instrument. The product ion scan was compared and confirmed by a library search of MS/MS spectra acquired from a reference standard. To search for new analogues of PDE-5 inhibitors, a precursor ion scan of an expected ion m/z 283, which was one of the mass fragments from the analogues of sildenafil or vardenafil, was performed and fragmentation of the precursor ion, by combining a precursor ion scan with automatic confirmation using EPI spectra, was acquired. Of the 37 DSs tested, two were eventually found to be adulterated with yohimbin and vardenafil, respectively. The approach proposed in this study would be valuable in characterizing chemical constituents of drug residues and their analogues with identical chemical substructures from complex natural and synthetic sources in DSs using an information-dependent acquisition-enhanced product ion (IDA-EPI) scan. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Lee, Hwa-mi AU - Lee, Bong Jin AD - Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, Gwanak-gu, Seoul 151-742, South Korea,Korea Food and Drug Administration, Incheon 402-835, South Korea Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 396 EP - 407 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 28 IS - 4 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts KW - Dietary supplements KW - Drugs KW - Food additives KW - Food contamination KW - Hybrids KW - Liquid chromatography KW - Mass spectroscopy KW - Pharmaceuticals KW - Risk assessment KW - Sildenafil KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1323800175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=A+novel+approach+to+simultaneous+screening+and+confirmation+of+regulated+pharmaceutical+compounds+in+dietary+supplements+by+LC%2FMS%2FMS+with+an+information-dependent+acquisition+method&rft.au=Lee%2C+Hwa-mi%3BLee%2C+Bong+Jin&rft.aulast=Lee&rft.aufirst=Hwa-mi&rft.date=2011-04-01&rft.volume=28&rft.issue=4&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.551947 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-04-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Liquid chromatography; Hybrids; Dietary supplements; Pharmaceuticals; Sildenafil; Food contamination; Drugs; Mass spectroscopy DO - http://dx.doi.org/10.1080/19440049.2011.551947 ER - TY - JOUR T1 - An approach to identifying preclinical biomarkers of susceptibility to drug-induced toxicity AN - 1171884187; 17335061 AB - Aim: Drug-induced toxicity that leads to termination of candidate drugs or postmarketing removal of approved drugs can potentially be explained by the existence of susceptible subpopulations. If the susceptible subpopulations are identified in advance, the drug's benefits could be maximized by optimal treatment decisions. This article presents a statistical model and an approach for identifying pharmacogenomic biomarkers of susceptibility to drug-induced toxicity for detecting the susceptible subpopulations. Materials & methods: Biomarkers are categorized into three disjoint sets: biomarkers of both susceptibility and exposure (A); biomarkers of susceptibility only (B); and biomarkers of exposure only (C). Set B contains the most useful biomarkers to identify susceptible subpopulations prior to drug exposure; these markers demonstrate no change in response before and after drug exposure. We present a sample size analysis to illustrate the issues and challenges facing identifying biomarker set B. Results: The required sample size increases as the proportion of the susceptible subpopulation decreases. The examples demonstrated that at least 75 subjects per group are needed for a population with a 5% susceptible subpopulation and more than 1000 are often necessary. Conclusion: This study demonstrates that the biomarkers identified by common methods are a mixture of biomarkers of exposure and susceptibility (A and C), it further demonstrates that the proposed approach could be used to identify biomarkers of susceptibility (B), where a large sample size may be required for adequate power and low false-positive rate. Original submitted 14 October 2010; Revision submitted 8 December 2010. JF - Pharmacogenomics AU - Lin, Wei-Jiun AU - Chen, James J AD - super(1)Division of Personalized Nutrition & Medicine, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA, jamesj.chen@fda.hhs.gov Y1 - 2011/04// PY - 2011 DA - Apr 2011 SP - 493 EP - 501 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 12 IS - 4 SN - 1462-2416, 1462-2416 KW - Genetics Abstracts; Toxicology Abstracts KW - Mathematical models KW - pharmacogenomics KW - Subpopulations KW - Statistical analysis KW - Drug development KW - Toxicity KW - biomarkers KW - Drugs KW - Models KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171884187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=An+approach+to+identifying+preclinical+biomarkers+of+susceptibility+to+drug-induced+toxicity&rft.au=Lin%2C+Wei-Jiun%3BChen%2C+James+J&rft.aulast=Lin&rft.aufirst=Wei-Jiun&rft.date=2011-04-01&rft.volume=12&rft.issue=4&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=14622416&rft_id=info:doi/10.2217%2Fpgs.10.204 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Number of references - 23 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Mathematical models; pharmacogenomics; Subpopulations; Statistical analysis; Drug development; Toxicity; Drugs; biomarkers; Models DO - http://dx.doi.org/10.2217/pgs.10.204 ER - TY - JOUR T1 - Creating A Framework For Getting Quality Into The Public Health System AN - 1030884156; 2011-146731 AB - The US health care system has undertaken concerted efforts to improve the quality of care that Americans receive, using well-documented strategies and new incentives found in the Affordable Care Act of 2010. Applying quality concepts to public health has lagged these efforts, however. This article describes two reports from the Department of Health and Human Services: Consensus statement on Quality in the Public Health System and Priority Areas for Improvement of Quality in Public Health. These reports define what is meant by public health quality, establish quality aims, and highlight priority areas needing improvement. We describe how these developments relate to the Affordable Care Act and serve as a call to action for ensuring a better future for population health. We present real-world examples of how a framework of quality concepts can be applied in the National Vaccine Safety Program and in a state office of minority health. Adapted from the source document. JF - Health Affairs AU - Honore, Peggy A AU - Wright, Donald AU - Berwick, Donald M AU - Clancy, Carolyn M AU - Lee, Peter AU - Nowinski, Juleigh AU - Koh, Howard K AD - Public Health Systems, Finance, and Quality Program in the Office of Healthcare Quality/Office of the Assistant Secretary for Health, Department of Health and Human Services (HHS), in Washington. D.C peggy.honore@hhs.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 737 EP - 745 PB - Project HOPE, Bethesda MD VL - 30 IS - 4 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Business and service sector - Insurance KW - Population groups, population policy, and demographics - National, ethnic, and minority groups KW - Health conditions and policy - Medicine and health care KW - United States KW - Minorities KW - Health insurance KW - Health policy KW - Medical service KW - Legislation KW - Vaccination and vaccines KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030884156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Creating+A+Framework+For+Getting+Quality+Into+The+Public+Health+System&rft.au=Honore%2C+Peggy+A%3BWright%2C+Donald%3BBerwick%2C+Donald+M%3BClancy%2C+Carolyn+M%3BLee%2C+Peter%3BNowinski%2C+Juleigh%3BKoh%2C+Howard+K&rft.aulast=Honore&rft.aufirst=Peggy&rft.date=2011-04-01&rft.volume=30&rft.issue=4&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0129 LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Public health; Legislation; Health insurance; Minorities; United States; Vaccination and vaccines; Medical service DO - http://dx.doi.org/10.1377/hlthaff.2011.0129 ER - TY - JOUR T1 - An Early Status Report On The Beacon Communities' Plans For Transformation Via Health Information Technology AN - 1030884010; 2011-146735 AB - The Beacon Community Program is part of a federal strategy for using health information technology as a foundation to improve the nation's health care system. In particular, Beacon Communities seek to increase the quality and efficiency of health care, improve the health of individuals and communities, and inform similar initiatives in other parts of the country. Each Beacon Community has set quality, efficiency, and health-related goals, and each is deploying multiple technology-enabled interventions to achieve them. Yet achieving large-scale and sustainable health care improvement also requires an implementation framework that can foster innovation and continuous learning from results. Based on the early experiences of the seventeen diverse Beacon Communities, this paper describes program design features that characterize how these initiatives are organized. Adapted from the source document. JF - Health Affairs AU - McKethan, Aaron AU - Brammer, Craig AU - Fatemi, Parastou AU - Kim, Minyoung AU - Kirtane, Janhavi AU - Kunzman, Jason AU - Rao, Shaline AU - Jain, Sachin H AD - Beacon Community Program in the Office of the National Coordinator for Health Information Technology, Department of Health and Human Services, in Washington, D.C aaron.mckethen@hhs.gov Y1 - 2011/04// PY - 2011 DA - April 2011 SP - 782 EP - 788 PB - Project HOPE, Bethesda MD VL - 30 IS - 4 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Science and technology policy - Computer science and information technology KW - Information technology KW - Health policy KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030884010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=An+Early+Status+Report+On+The+Beacon+Communities%27+Plans+For+Transformation+Via+Health+Information+Technology&rft.au=McKethan%2C+Aaron%3BBrammer%2C+Craig%3BFatemi%2C+Parastou%3BKim%2C+Minyoung%3BKirtane%2C+Janhavi%3BKunzman%2C+Jason%3BRao%2C+Shaline%3BJain%2C+Sachin+H&rft.aulast=McKethan&rft.aufirst=Aaron&rft.date=2011-04-01&rft.volume=30&rft.issue=4&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0166 LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Medical service; Information technology DO - http://dx.doi.org/10.1377/hlthaff.2011.0166 ER - TY - JOUR T1 - Haptoglobin: old protein with new functions. AN - 850562611; 21159311 AB - When released from red blood cells (RBCs), hemoglobin (Hb) is extremely toxic due in large part to the redox activity of its heme center. Nature however, has provided a multitude of protective mechanisms that can detoxify free Hb effectively under physiological conditions. Chief amongst them is haptoglobin (Hp) which chaperones Hb subunits to the macrophages for safe degradation. Recent research on the interactions between Hb and Hp under oxidative conditions revealed that Hp specifically shields key amino acids on the Hb molecule, allowing the heme to consume oxidants and short-circuits the emerging and damaging radicals. Moreover, animal studies showed that the infusion of Hb complexed with Hp prevents Hb-induced systemic hypertension and tissue injury. It may prove necessary to explore these protective clearing mechanisms to counter the toxicity associated with free Hb when used as oxygen therapeutics in hemolytic anemias and in RBC storage lesions. Published by Elsevier B.V. JF - Clinica chimica acta; international journal of clinical chemistry AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA. abdu.alayash@fda.hhs.gov Y1 - 2011/03/18/ PY - 2011 DA - 2011 Mar 18 SP - 493 EP - 498 VL - 412 IS - 7-8 KW - Haptoglobins KW - 0 KW - Hemoglobins KW - Index Medicus KW - Oxidation-Reduction KW - Blood Pressure -- physiology KW - Hemoglobins -- toxicity KW - Humans KW - Hemoglobins -- physiology KW - Haptoglobins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/850562611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.atitle=Haptoglobin%3A+old+protein+with+new+functions.&rft.au=Alayash%2C+Abdu+I&rft.aulast=Alayash&rft.aufirst=Abdu&rft.date=2011-03-18&rft.volume=412&rft.issue=7-8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Clinica+chimica+acta%3B+international+journal+of+clinical+chemistry&rft.issn=1873-3492&rft_id=info:doi/10.1016%2Fj.cca.2010.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-08-07 N1 - Date created - 2011-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.cca.2010.12.011 ER - TY - JOUR T1 - I-131 Dose Response for Incident Thyroid Cancers in Ukraine Related to the Chornobyl Accident AN - 1678009682; 16210162 AB - Background: Current knowledge about Chornobyl-related thyroid cancer risks comes from ecological studies based on grouped doses, case-control studies, and studies of prevalent cancers. Objective: To address this limitation, we evaluated the dose-response relationship for incident thyroid cancers using measurement-based individual iodine-131 (I-131) thyroid dose estimates in a prospective analytic cohort study. Methods: The cohort consists of individuals & 18 years of age on 26 April 1986 who resided in three contaminated oblasts (states) of Ukraine and underwent up to four thyroid screening examinations between 1998 and 2007 (n = 12,514). Thyroid doses of I-131 were estimated based on individual radioactivity measurements taken within 2 months after the accident, environmental transport models, and interview data. Excess radiation risks were estimated using Poisson regression models. Results: Sixty-five incident thyroid cancers were diagnosed during the second through fourth screenings and 73,004 person-years (PY) of observation. The dose-response relationship was consistent with linearity on relative and absolute scales, although the excess relative risk (ERR) model described data better than did the excess absolute risk (EAR) model. The ERR per gray was 1.91 [95% confidence interval (CI), 0.43-6.34], and the EAR per 104 PY/Gy was 2.21 (95% CI, 0.04-5.78). The ERR per gray varied significantly by oblast of residence but not by time since exposure, use of iodine prophylaxis, iodine status, sex, age, or tumor size. Conclusions: I-131-related thyroid cancer risks persisted for two decades after exposure, with no evidence of decrease during the observation period. The radiation risks, although smaller, are compatible with those of retrospective and ecological post-Chornobyl studies. JF - Environmental Health Perspectives AU - Brenner, Alina V AU - Tronko, Mykola D AU - Hatch, Maureen AU - Bogdanova, Tetyana I AU - Oliynik, Valery A AU - Lubin, Jay H AU - Zablotska, Lydia B AU - Tereschenko, Valery P AU - McConnell, Robert J AU - Zamotaeva, Galina A AU - O'Kane, Patrick AU - Bouville, Andre C AU - Chaykovskaya, Ludmila V AU - Greenebaum, Ellen AU - Paster, Ihor P AU - Shpak, Victor M AU - Ron, Elaine AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2011/03/17/ PY - 2011 DA - 2011 Mar 17 SP - 933 EP - 939 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 119 IS - 7 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Chernobyl nuclear accident KW - Chornobyl, Ukraine, 1986 KW - dose-response relationship KW - incidence, thyroid neoplasms/epidemiology KW - iodine KW - radioactive KW - radiation KW - Screening KW - Risk KW - Age KW - Accidents KW - Iodine KW - Ear KW - Ecological risk assessment KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1678009682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=I-131+Dose+Response+for+Incident+Thyroid+Cancers+in+Ukraine+Related+to+the+Chornobyl+Accident&rft.au=Brenner%2C+Alina+V%3BTronko%2C+Mykola+D%3BHatch%2C+Maureen%3BBogdanova%2C+Tetyana+I%3BOliynik%2C+Valery+A%3BLubin%2C+Jay+H%3BZablotska%2C+Lydia+B%3BTereschenko%2C+Valery+P%3BMcConnell%2C+Robert+J%3BZamotaeva%2C+Galina+A%3BO%27Kane%2C+Patrick%3BBouville%2C+Andre+C%3BChaykovskaya%2C+Ludmila+V%3BGreenebaum%2C+Ellen%3BPaster%2C+Ihor+P%3BShpak%2C+Victor+M%3BRon%2C+Elaine&rft.aulast=Brenner&rft.aufirst=Alina&rft.date=2011-03-17&rft.volume=119&rft.issue=7&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1002674 ER - TY - JOUR T1 - Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins AN - 867739643; 14525393 AB - Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares the advantages and limitations of both methods. For a given laboratory, the selection of either method may be based primarily on practicality and less on any deficiencies in scientific merit. JF - Toxicon AU - DeGrasse, Stacey L AU - van de Riet, Jeffrey AU - Hatfield, Robert AU - Turner, Andrew AD - US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 619 EP - 624 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 57 IS - 4 SN - 0041-0101, 0041-0101 KW - Toxicology Abstracts KW - LC KW - Oxidation KW - Paralytic shellfish toxins KW - Saxitoxin KW - Validation KW - Fluorescence KW - Liquid chromatography KW - Communication KW - Toxins KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867739643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Pre-+versus+post-column+oxidation+liquid+chromatography+fluorescence+detection+of+paralytic+shellfish+toxins&rft.au=DeGrasse%2C+Stacey+L%3Bvan+de+Riet%2C+Jeffrey%3BHatfield%2C+Robert%3BTurner%2C+Andrew&rft.aulast=DeGrasse&rft.aufirst=Stacey&rft.date=2011-03-15&rft.volume=57&rft.issue=4&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.12.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fluorescence; Liquid chromatography; Oxidation; Communication; Toxins DO - http://dx.doi.org/10.1016/j.toxicon.2010.12.017 ER - TY - JOUR T1 - Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veterans. AN - 855910904; 21381009 AB - Autoimmunity is clearly linked with hematologic malignancies, but less is known about autoimmunity and alimentary tract cancer risk, despite the specific targeting of alimentary organs and tissues by several autoimmune diseases. The authors therefore conducted the first systematic evaluation of a broad range of specific autoimmune diseases and risk for subsequent alimentary tract cancer. On the basis of 4,501,578 US male veterans, the authors identified 96,277 men who developed alimentary tract cancer during up to 26.2 years of follow-up. By using Poisson regression methods, the authors calculated relative risks (RRs) and 95% confidence intervals. A history of autoimmune disease with localized alimentary tract effects generally increased cancer risks in the organ(s) affected by the autoimmune disease, such as primary biliary cirrhosis and liver cancer (RR, 6.01; 95% confidence interval [CI], 4.76-7.57); pernicious anemia and stomach cancer (RR, 3.17; 95% CI, 2.47-4.07); and ulcerative colitis and small intestine, colon, and rectal cancers (RR, 2.53; 95% CI, 1.05-6.11; RR, 2.06; 95% CI, 1.70-2.48; and RR, 2.07; 95% CI, 1.62-2.64, respectively). In addition, a history of celiac disease, reactive arthritis (Reiter disease), and systemic sclerosis all were associated significantly with increased risk of esophageal cancer (RR, 1.86-2.86). Autoimmune diseases without localized alimentary tract effects generally were not associated with alimentary tract cancer risk, with the exception of decreased risk for multiple alimentary tract cancers associated with a history of multiple sclerosis. These findings support the importance of localized inflammation in alimentary tract carcinogenesis. Future research is needed to confirm the findings and improve understanding of underlying mechanisms by which autoimmune diseases contribute to alimentary tract carcinogenesis. Published 2010 by the American Cancer Society. JF - Cancer AU - Landgren, Annelie M AU - Landgren, Ola AU - Gridley, Gloria AU - Dores, Graça M AU - Linet, Martha S AU - Morton, Lindsay M AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 1163 EP - 1171 VL - 117 IS - 6 SN - 0008-543X, 0008-543X KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Humans KW - Inflammation -- ethnology KW - Aged KW - Risk KW - Aged, 80 and over KW - Adult KW - Gastrointestinal Tract -- immunology KW - Inflammation -- immunology KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Inflammation -- complications KW - Male KW - Autoimmune Diseases -- ethnology KW - Gastrointestinal Neoplasms -- ethnology KW - Carcinoma -- ethnology KW - Gastrointestinal Neoplasms -- epidemiology KW - Carcinoma -- etiology KW - Veterans -- statistics & numerical data KW - Carcinoma -- epidemiology KW - Autoimmune Diseases -- epidemiology KW - Carcinoma -- immunology KW - Gastrointestinal Neoplasms -- etiology KW - Gastrointestinal Neoplasms -- immunology KW - Autoimmune Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855910904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Autoimmune+disease+and+subsequent+risk+of+developing+alimentary+tract+cancers+among+4.5+million+US+male+veterans.&rft.au=Landgren%2C+Annelie+M%3BLandgren%2C+Ola%3BGridley%2C+Gloria%3BDores%2C+Gra%C3%A7a+M%3BLinet%2C+Martha+S%3BMorton%2C+Lindsay+M&rft.aulast=Landgren&rft.aufirst=Annelie&rft.date=2011-03-15&rft.volume=117&rft.issue=6&rft.spage=1163&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.25524 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-12 N1 - Date created - 2011-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatogastroenterology. 2008 May-Jun;55(84):821-5 [18705275] J Hepatol. 2008 Sep;49(3):451-60 [18640737] Physiology (Bethesda). 2008 Dec;23:350-9 [19074742] Arch Intern Med. 2009 Feb 23;169(4):357-63 [19237719] Blood. 2009 Jun 25;113(26):6511-21 [19395674] Hepatogastroenterology. 2000 Jan-Feb;47(31):57-70 [10690586] Nature. 2000 Mar 23;404(6776):398-402 [10746728] Int J Cancer. 2000 Nov 1;88(3):497-502 [11054684] Cancer. 2001 Feb 15;91(4):854-62 [11241255] Can J Gastroenterol. 2001 Apr;15(4):231-6 [11331924] Nat Rev Cancer. 2002 Jan;2(1):28-37 [11902583] Gastroenterology. 2002 Nov;123(5):1428-35 [12404215] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Am J Hum Genet. 2003 Feb;72(2):448-53 [12516030] Gut. 2003 Jul;52(7):938-41 [12801947] Gut. 1989 Mar;30(3):333-8 [2707633] Br J Cancer. 1989 May;59(5):810-3 [2736218] Cancer. 1993 Feb 1;71(3):745-50 [8431855] IARC Sci Publ. 1987;(82):1-406 [2577937] Medicine (Baltimore). 1994 Sep;73(5):241-5 [7934808] J Exp Med. 1995 Dec 1;182(6):1985-96 [7500044] Br J Cancer. 1996 Apr;73(8):998-1000 [8611439] Acta Neurol Scand. 1996 Jun;93(6):411-5 [8836302] Eur J Cancer. 1996 Sep;32A(10):1753-7 [8983286] J Clin Gastroenterol. 1997 Jun;24(4):270-3 [9252858] J Clin Invest. 1999 Mar;103(6):807-15 [10079101] Dent Clin North Am. 2005 Jan;49(1):127-41, ix [15567365] Breast Cancer Res Treat. 2005 Feb;89(3):265-70 [15754125] Inflamm Bowel Dis. 2005 Sep;11(9):828-32 [16116317] Ann Rheum Dis. 2005 Oct;64(10):1421-6 [15829572] Int J Cancer. 2006 Feb 15;118(4):979-84 [16152598] Gastrointest Endosc. 2006 May;63(6):868-70 [16650562] J Rheumatol. 2006 Jun;33(6):1113-6 [16622904] Nat Rev Cancer. 2006 Sep;6(9):674-87 [16929323] J Clin Gastroenterol. 2006 Oct;40(9):769-75 [17016130] Dis Colon Rectum. 2007 Jun;50(6):839-55 [17308939] Nat Genet. 2007 Sep;39(9):1108-13 [17660816] N Engl J Med. 2007 Aug 30;357(9):851-62 [17660530] Dig Dis. 2007;25(3):267-9 [17827953] Autoimmun Rev. 2007 Sep;6(8):559-65 [17854749] Clin Gastroenterol Hepatol. 2007 Nov;5(11):1347-53 [17702659] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2416-24 [18006931] World J Gastroenterol. 2007 Dec 21;13(47):6344-6 [18081222] Am Surg. 2007 Nov;73(11):1181-7 [18092659] Eur J Gastroenterol Hepatol. 2008 Apr;20(4):297-304 [18334873] Eur J Gastroenterol Hepatol. 2008 May;20(5):384-92 [18403939] Mult Scler. 2008 Apr;14(3):399-405 [18420778] J Am Acad Dermatol. 2008 Jul;59(1):113-21 [18436339] Arthritis Res Ther. 2008;10(2):R45 [18433475] Blood. 2008 Jul 15;112(2):362-73 [18354038] Int J Cancer. 2008 Sep 15;123(6):1417-21 [18561319] J Intern Med. 2008 Dec;264(6):514-27 [19017176] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/cncr.25524 ER - TY - JOUR T1 - Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC-electrospray tandem mass spectrometry. AN - 855910594; 21345750 AB - This paper reports the development and validation of a methodology for the low-level quantification of melamine and cyanuric acid in limited samples of rat serum. The methodology, based upon ion-exchange solid phase extraction (SPE) and ultra-performance liquid chromatography (UPLC) coupled with electrospray tandem mass spectrometry (MS/MS) in multiple reaction monitoring (MRM) mode, relies on the use of stable isotope-labeled internal standards and requires only 15 μL samples of serum. The method provides a recovery of 80-110% of melamine with a signal suppression of ca. 55%, and a recovery of 50-90% of cyanuric acid with a signal suppression ca. 40-60%, affording lower limits of quantification (LLOQ) for melamine or cyanuric acid of, respectively, 5 ppb (mean accuracy 109%; CV=4.9%) and 10 ppb (mean accuracy 96%; CV=8.6%). The small sample requirements, excellent sensitivity, accuracy and precision, and high-throughput (5 min of instrument run time) make this methodology optimal for toxicokinetic or exposure assessments studies. Published by Elsevier B.V. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Jacob, Cristina C AU - Gamboa da Costa, Gonçalo AD - Division of Biochemical Toxicology, US FDA National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2011/03/15/ PY - 2011 DA - 2011 Mar 15 SP - 652 EP - 656 VL - 879 IS - 9-10 KW - Triazines KW - 0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Sensitivity and Specificity KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Reproducibility of Results KW - Tandem Mass Spectrometry -- methods KW - Solid Phase Extraction KW - Chromatography, High Pressure Liquid -- methods KW - Triazines -- blood KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855910594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Low-level+quantification+of+melamine+and+cyanuric+acid+in+limited+samples+of+rat+serum+by+UPLC-electrospray+tandem+mass+spectrometry.&rft.au=Jacob%2C+Cristina+C%3BGamboa+da+Costa%2C+Gon%C3%A7alo&rft.aulast=Jacob&rft.aufirst=Cristina&rft.date=2011-03-15&rft.volume=879&rft.issue=9-10&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2011.01.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-30 N1 - Date created - 2011-03-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Vet Diagn Invest. 2007 Nov;19(6):616-24 [17998549] Food Chem Toxicol. 2008 Mar;46(3):1196-200 [18166259] Toxicol Sci. 2008 Nov;106(1):251-62 [18689873] J Sep Sci. 2009 Sep;32(17):2974-8 [19630004] J Chromatogr A. 2009 Oct 30;1216(44):7595-601 [19493536] J Agric Food Chem. 2010 Jan 13;58(1):108-11 [20014856] J Agric Food Chem. 2010 Jan 27;58(2):943-8 [20038098] Regul Toxicol Pharmacol. 2010 Mar;56(2):193-6 [19788907] J AOAC Int. 2009 Nov-Dec;92(6):1833-8 [20166602] Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2542-6 [20435082] Food Chem Toxicol. 2010 Jul;48(7):1791-5 [20362637] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jchromb.2011.01.035 ER - TY - RPRT T1 - Emergency Department Visits for Drug-Related Suicide Attempts Involving Antidepressants by Adolescents and Young Adults: 2004 to 2008. The DAWN Report AN - 964181110; ED525062 AB - In 2008, adolescents made 23,124 visits to the emergency department (ED) for drug-related suicide attempts, and young adults made 38,036 such visits; of these visits, 23.0 percent (5,312 visits) among adolescents and 17.6 percent (6,700 visits) among young adults involved antidepressants. Among ED visits for suicide attempts involving antidepressants, more than two thirds of visits by adolescents (68.4 percent) and more than three fourths of visits by young adults (78.0 percent) involved other substances in addition to antidepressants. One tenth (10.2 percent) of visits by adolescents and nearly one fourth (22.6 percent) of those made by young adults involved antidepressants in combination with alcohol. One third (32.9 percent) of visits for drug-related suicide attempts made by adolescents and one half (49.4 percent) of visits made by young adults resulted in hospitalization. (Contains 1 figure, 2 tables and 11 endnotes.) Y1 - 2011/03/08/ PY - 2011 DA - 2011 Mar 08 SP - 6 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Drinking KW - Substance Abuse KW - Drug Therapy KW - Gender Differences KW - Suicide KW - Narcotics KW - Mental Health KW - Young Adults KW - Marijuana KW - Alcohol Abuse KW - Public Health KW - Incidence KW - Age Differences KW - Adolescents KW - Drug Abuse KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964181110?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Evaluation of the Hypersensitivity Potential of Alternative Butter Flavorings: Are They Safe Substitutes for Diacetyl? T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313017688; 6047858 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Anderson, S AU - Franko, J AU - Lukomska, E AU - Meade, B Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - hypersensitivity KW - Diacetyl KW - Flavorings KW - Hypersensitivity KW - Butter UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Evaluation+of+the+Hypersensitivity+Potential+of+Alternative+Butter+Flavorings%3A+Are+They+Safe+Substitutes+for+Diacetyl%3F&rft.au=Anderson%2C+S%3BFranko%2C+J%3BLukomska%2C+E%3BMeade%2C+B&rft.aulast=Anderson&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of Shiga-like Protein Toxins I and II from Escherichia Coli O157:H7 T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313017162; 6047850 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tolleson, W AU - Nguyen, K AU - Mugengana, A AU - Melchior, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxins KW - Escherichia coli UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Characterization+of+Shiga-like+Protein+Toxins+I+and+II+from+Escherichia+Coli+O157%3AH7&rft.au=Tolleson%2C+W%3BNguyen%2C+K%3BMugengana%2C+A%3BMelchior%2C+W&rft.aulast=Tolleson&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Exenatide and Sitagliptin: Their Role in Autophagosome Regulated Toxicity in Pancreatitis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313010440; 6047783 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Rouse, R AU - Zhang, L AU - Volpe, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Phagosomes KW - Pancreatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313010440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Exenatide+and+Sitagliptin%3A+Their+Role+in+Autophagosome+Regulated+Toxicity+in+Pancreatitis&rft.au=Rouse%2C+R%3BZhang%2C+L%3BVolpe%2C+D&rft.aulast=Rouse&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Use of E-Cadherin Immunofluorescence in Pulmonary Toxicologic Pathology Studies T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313006475; 6046011 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Battelli, L AU - Castranova, V AU - Porter, D AU - Friend, S AU - Schwegler-Berry, D AU - Willard, P AU - Hubbs, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Pathology KW - Lung KW - E-Cadherin KW - Immunofluorescence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Use+of+E-Cadherin+Immunofluorescence+in+Pulmonary+Toxicologic+Pathology+Studies&rft.au=Battelli%2C+L%3BCastranova%2C+V%3BPorter%2C+D%3BFriend%2C+S%3BSchwegler-Berry%2C+D%3BWillard%2C+P%3BHubbs%2C+A&rft.aulast=Battelli&rft.aufirst=L&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Sub-Chronic Naphthalene Inhalation Causes a Decrease in P53 Codon 271 Cat Mutant Fraction in the Nasal Respiratory Epithelium of Male Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313006323; 6047389 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Myers, M AU - Wong, B AU - Gross, E AU - Clewell, H AU - Dodd, D AU - Parsons, B AU - Meng, F AU - Wang, Y Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Naphthalene KW - Inhalation KW - Mutants KW - Rats KW - Codons KW - p53 protein KW - Respiratory tract KW - Respiration KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Sub-Chronic+Naphthalene+Inhalation+Causes+a+Decrease+in+P53+Codon+271+Cat+Mutant+Fraction+in+the+Nasal+Respiratory+Epithelium+of+Male+Rats&rft.au=Myers%2C+M%3BWong%2C+B%3BGross%2C+E%3BClewell%2C+H%3BDodd%2C+D%3BParsons%2C+B%3BMeng%2C+F%3BWang%2C+Y&rft.aulast=Myers&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Silver Nanowires Induced Inflammation in an in Vitro Human Alveolar Lung Model T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313006047; 6047617 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Roberts, J AU - Hussain, S AU - Schaeublin, N AU - Estep, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - Silver KW - Alveoli KW - nanotechnology KW - Inflammation KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Silver+Nanowires+Induced+Inflammation+in+an+in+Vitro+Human+Alveolar+Lung+Model&rft.au=Roberts%2C+J%3BHussain%2C+S%3BSchaeublin%2C+N%3BEstep%2C+C&rft.aulast=Roberts&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Factors Affecting the Pulmonary Response to Carbon Nanotubes. T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313005863; 6047236 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Castranova, V Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - nanotechnology KW - Carbon KW - Lung KW - nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Factors+Affecting+the+Pulmonary+Response+to+Carbon+Nanotubes.&rft.au=Castranova%2C+V&rft.aulast=Castranova&rft.aufirst=V&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Cytotoxicity and Gene Expression Alterations Following Treatment of TK6 Cells with Etoposide and Sodium Chloride T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313003834; 6046851 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chen, Y AU - Moore, M AU - Fuscoe, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cytotoxicity KW - Gene expression KW - Etoposide KW - Sodium chloride UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Cytotoxicity+and+Gene+Expression+Alterations+Following+Treatment+of+TK6+Cells+with+Etoposide+and+Sodium+Chloride&rft.au=Chen%2C+Y%3BMoore%2C+M%3BFuscoe%2C+J&rft.aulast=Chen&rft.aufirst=Y&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Nitroxides Tempo and Tempol Induce TK Mutations in Mouse Lymphoma Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313003458; 6046843 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Guo, X AU - GuoGuo, L AU - Moore, M AU - Mei, N Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - lymphoma KW - Mutation KW - Lymphoma KW - Protein-tyrosine kinase KW - tempol KW - Nitroxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Nitroxides+Tempo+and+Tempol+Induce+TK+Mutations+in+Mouse+Lymphoma+Cells&rft.au=Guo%2C+X%3BGuoGuo%2C+L%3BMoore%2C+M%3BMei%2C+N&rft.aulast=Guo&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Manifestation and Persistence of Pig-A Mutant Frequency in C57BL/6 Mice Treated with Different Doses of ENU T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313003408; 6046842 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Bhalli, J AU - Pearce, M AU - Dobrovolsky, V AU - Heflich, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Mice KW - Mutants KW - Mutant frequency KW - Ethyl nitrosourea UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Manifestation+and+Persistence+of+Pig-A+Mutant+Frequency+in+C57BL%2F6+Mice+Treated+with+Different+Doses+of+ENU&rft.au=Bhalli%2C+J%3BPearce%2C+M%3BDobrovolsky%2C+V%3BHeflich%2C+R&rft.aulast=Bhalli&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Examining the Mutagenicity of Ethyl Methanesulfonate in Mice Using the PIG-A, HPRT, and GPT Delta Assays T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313003346; 6046841 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Cao, X AU - Shaddock, J AU - Mittelstaedt, R AU - Dobrovolsky, V AU - Shelton, S AU - Manjanatha, M AU - Heflich, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Deltas KW - Mice KW - Mutagenicity KW - Ethyl methanesulfonate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313003346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Examining+the+Mutagenicity+of+Ethyl+Methanesulfonate+in+Mice+Using+the+PIG-A%2C+HPRT%2C+and+GPT+Delta+Assays&rft.au=Cao%2C+X%3BShaddock%2C+J%3BMittelstaedt%2C+R%3BDobrovolsky%2C+V%3BShelton%2C+S%3BManjanatha%2C+M%3BHeflich%2C+R&rft.aulast=Cao&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effects of Radio Frequency Radiation Exposure from Mobile Phones on Brain Microvessel Endothelial Cells, a Model of Blood Brain Barrier: An in Vitro Study T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000900; 6048062 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Howard, P AU - Walker, N AU - Wyde, M AU - Paule, M AU - Ali, S AU - Cuevas, E AU - Lantz, S AU - Trickler, W AU - Robinson, B AU - Newport, G AU - Desta, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Brain KW - cellular telephones KW - Radiation KW - Cellular telephones KW - Endothelial cells KW - Blood-brain barrier KW - Radio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Effects+of+Radio+Frequency+Radiation+Exposure+from+Mobile+Phones+on+Brain+Microvessel+Endothelial+Cells%2C+a+Model+of+Blood+Brain+Barrier%3A+An+in+Vitro+Study&rft.au=Howard%2C+P%3BWalker%2C+N%3BWyde%2C+M%3BPaule%2C+M%3BAli%2C+S%3BCuevas%2C+E%3BLantz%2C+S%3BTrickler%2C+W%3BRobinson%2C+B%3BNewport%2C+G%3BDesta%2C+A&rft.aulast=Howard&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Design and Development of an Institutional Knowledge-Base at Fda'S Center for Food Safety and Applied Nutrition T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000774; 6045595 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Arvidson, K AU - McCarthy, A AU - Yang, C AU - Hristozov, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Nutrition KW - Food contamination KW - FDA KW - Food KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Design+and+Development+of+an+Institutional+Knowledge-Base+at+Fda%27S+Center+for+Food+Safety+and+Applied+Nutrition&rft.au=Arvidson%2C+K%3BMcCarthy%2C+A%3BYang%2C+C%3BHristozov%2C+D&rft.aulast=Arvidson&rft.aufirst=K&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Vivo Longitudinal Magnetic Resonance Spectroscopy of the Developing Rat Brain T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000476; 6048053 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Liachenko, S AU - Ramu, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Spectroscopy KW - Brain KW - Magnetic resonance spectroscopy KW - Resonance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=In+Vivo+Longitudinal+Magnetic+Resonance+Spectroscopy+of+the+Developing+Rat+Brain&rft.au=Liachenko%2C+S%3BRamu%2C+J&rft.aulast=Liachenko&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - DNA Methylation and Histone Modification Changes in the Livers of C57BL/6J Mice Exposed to 1, 3-Butadiene by Inhalation T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000341; 6046387 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Koturbash, I AU - Scherhag, A AU - Jessica, S AU - Wanda, B AU - James, S AU - Frederick, B AU - Igor, P AU - Ivan, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Inhalation KW - Mice KW - Liver KW - Histones KW - DNA methylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=DNA+Methylation+and+Histone+Modification+Changes+in+the+Livers+of+C57BL%2F6J+Mice+Exposed+to+1%2C+3-Butadiene+by+Inhalation&rft.au=Koturbash%2C+I%3BScherhag%2C+A%3BJessica%2C+S%3BWanda%2C+B%3BJames%2C+S%3BFrederick%2C+B%3BIgor%2C+P%3BIvan%2C+R&rft.aulast=Koturbash&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epigenetic Changes During Cocarcinogenesis of N, N-Diethylnitrosamine and Carbon Tetrachloride in Mouse Liver T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1313000039; 6046381 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kutanzi, K AU - Koturbash, I AU - Uehara, T AU - Kosyk, O AU - Pogribny, I AU - Rusyn, I Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Liver KW - epigenetics KW - Carbon tetrachloride UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Epigenetic+Changes+During+Cocarcinogenesis+of+N%2C+N-Diethylnitrosamine+and+Carbon+Tetrachloride+in+Mouse+Liver&rft.au=Kutanzi%2C+K%3BKoturbash%2C+I%3BUehara%2C+T%3BKosyk%2C+O%3BPogribny%2C+I%3BRusyn%2C+I&rft.aulast=Kutanzi&rft.aufirst=K&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Local and Systemic Toxicity of Implanted Accelerator-Free Polychloroprene-Type and Latex Surgical Glove Material T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312999745; 6046992 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Goravanahally, M AU - Hubbs, A AU - Nicolaysen, P AU - Kashon, M AU - Battelli, L AU - Law, B AU - Willard, P AU - Siegel, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - surgery KW - gloves KW - latex KW - Gloves KW - Latex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Local+and+Systemic+Toxicity+of+Implanted+Accelerator-Free+Polychloroprene-Type+and+Latex+Surgical+Glove+Material&rft.au=Goravanahally%2C+M%3BHubbs%2C+A%3BNicolaysen%2C+P%3BKashon%2C+M%3BBattelli%2C+L%3BLaw%2C+B%3BWillard%2C+P%3BSiegel%2C+P&rft.aulast=Goravanahally&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Fda'S Liver Toxicity Knowledge Base (LTKB) Project T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312999363; 6046371 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tong, W AU - Chen, M AU - Vikrant, V AU - Shi, Q AU - Zhang, M AU - Guo, L AU - Liu, Z AU - Zhang, J AU - Bearden, E Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Liver KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Fda%27S+Liver+Toxicity+Knowledge+Base+%28LTKB%29+Project&rft.au=Tong%2C+W%3BChen%2C+M%3BVikrant%2C+V%3BShi%2C+Q%3BZhang%2C+M%3BGuo%2C+L%3BLiu%2C+Z%3BZhang%2C+J%3BBearden%2C+E&rft.aulast=Tong&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Silico Predictive Model for Druginduced Phospholipidosis Using Bioepisteme Software T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997689; 6045577 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Choi, S AU - Valerio, L AU - Sadrieh, N Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - prediction models KW - Computer programs KW - Models KW - Prediction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=In+Silico+Predictive+Model+for+Druginduced+Phospholipidosis+Using+Bioepisteme+Software&rft.au=Choi%2C+S%3BValerio%2C+L%3BSadrieh%2C+N&rft.aulast=Choi&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of a Qsar Model for Phospholipidosis Using a Hierarchical Scaffold Tree of Significant Molecular Features T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997642; 6045576 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kruhlak, N AU - Cross, K AU - Orogo, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Trees KW - scaffolds KW - Molecular modelling KW - Structure-activity relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Characterization+of+a+Qsar+Model+for+Phospholipidosis+Using+a+Hierarchical+Scaffold+Tree+of+Significant+Molecular+Features&rft.au=Kruhlak%2C+N%3BCross%2C+K%3BOrogo%2C+A&rft.aulast=Kruhlak&rft.aufirst=N&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Iccvam Evaluation of the Local Lymph Node Assay (LLNA) for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997246; 6046954 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Brown, P AU - Matheson, J AU - Jacobs, A AU - McMahon, T AU - Germolec, D AU - Wind, M AU - Stokes, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - lymph nodes KW - Contact dermatitis KW - Chemicals KW - Local lymph node assay KW - Lymph UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Iccvam+Evaluation+of+the+Local+Lymph+Node+Assay+%28LLNA%29+for+Potency+Categorization+of+Chemicals+Causing+Allergic+Contact+Dermatitis+in+Humans&rft.au=Brown%2C+P%3BMatheson%2C+J%3BJacobs%2C+A%3BMcMahon%2C+T%3BGermolec%2C+D%3BWind%2C+M%3BStokes%2C+W&rft.aulast=Brown&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Iccvam Evaluation and Recommendations on the Non-Radioactive Llna: Brdu-Elisa for Evaluating Allergic Contact Dermatitis Hazards T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312997190; 6046953 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Jacobs, A AU - Matheson, J AU - Wind, M AU - Malshet, V AU - Toy, J AU - Stokes, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Contact dermatitis KW - Hazards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Iccvam+Evaluation+and+Recommendations+on+the+Non-Radioactive+Llna%3A+Brdu-Elisa+for+Evaluating+Allergic+Contact+Dermatitis+Hazards&rft.au=Jacobs%2C+A%3BMatheson%2C+J%3BWind%2C+M%3BMalshet%2C+V%3BToy%2C+J%3BStokes%2C+W&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Age and Sex Differences in Renal Gene Expression During the Rat Life Cycle T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312996766; 6047029 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kwekel, J AU - Desai, V AU - Han, T AU - Branham, W AU - Moland, C AU - Fuscoe, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Life cycle KW - Age KW - Gene expression KW - Kidneys KW - Sex differences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Age+and+Sex+Differences+in+Renal+Gene+Expression+During+the+Rat+Life+Cycle&rft.au=Kwekel%2C+J%3BDesai%2C+V%3BHan%2C+T%3BBranham%2C+W%3BMoland%2C+C%3BFuscoe%2C+J&rft.aulast=Kwekel&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Nail Manganese as a Biomarker of Welding Fume Exposure T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312995900; 6047753 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Antonini, J AU - Roberts, J AU - Sriram, K Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bioindicators KW - Welding KW - Fumes KW - Manganese KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Nail+Manganese+as+a+Biomarker+of+Welding+Fume+Exposure&rft.au=Antonini%2C+J%3BRoberts%2C+J%3BSriram%2C+K&rft.aulast=Antonini&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Caenorhabditis Elegans as an Alternative Model to Evaluate Nanomaterial Toxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312995476; 6046431 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Komatsu, L AU - Olejnik, N AU - Tyner, K AU - Sprando, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - nanotechnology KW - Models KW - Caenorhabditis elegans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Caenorhabditis+Elegans+as+an+Alternative+Model+to+Evaluate+Nanomaterial+Toxicity&rft.au=Komatsu%2C+L%3BOlejnik%2C+N%3BTyner%2C+K%3BSprando%2C+R&rft.aulast=Komatsu&rft.aufirst=L&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - SWCNT Exposure of Alveolar Epithelial Cells and Macrophages Induced OPN and TGF-?1 Response T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312995419; 6047596 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Waltz, M AU - Murray, A AU - Kisin, E AU - Shvedova, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Epithelial cells KW - Alveoli KW - Macrophages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=SWCNT+Exposure+of+Alveolar+Epithelial+Cells+and+Macrophages+Induced+OPN+and+TGF-%3F1+Response&rft.au=Waltz%2C+M%3BMurray%2C+A%3BKisin%2C+E%3BShvedova%2C+A&rft.aulast=Waltz&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Updated Aluminum Pharmacokinetics in Infants Following Exposures through Diet and Vaccination T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312994222; 6046163 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Mitkus, R AU - Walderhaug, M AU - Hess, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Aluminum KW - Diets KW - Infants KW - Pharmacokinetics KW - Vaccination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312994222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Updated+Aluminum+Pharmacokinetics+in+Infants+Following+Exposures+through+Diet+and+Vaccination&rft.au=Mitkus%2C+R%3BWalderhaug%2C+M%3BHess%2C+M&rft.aulast=Mitkus&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Inhalation of Ortho-Phthalaldehyde Vapor Causes Systemic Sensitization and Allergic Inflammation in the Lymph Nodes, Nasal Mucosa, and Lung of Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312991280; 6045537 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Johnson, V AU - Wang, W AU - Fluharty, K AU - Yucesoy, B AU - Reynolds, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - lymph nodes KW - Lung KW - Inhalation KW - Mice KW - Vapors KW - Lymph nodes KW - Hypersensitivity KW - Mucosa KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312991280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Inhalation+of+Ortho-Phthalaldehyde+Vapor+Causes+Systemic+Sensitization+and+Allergic+Inflammation+in+the+Lymph+Nodes%2C+Nasal+Mucosa%2C+and+Lung+of+Mice&rft.au=Johnson%2C+V%3BWang%2C+W%3BFluharty%2C+K%3BYucesoy%2C+B%3BReynolds%2C+J&rft.aulast=Johnson&rft.aufirst=V&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Computational Modeling for Qt Prolongation: A Drug Cardiovascular Safety Endpoint of Paramount Importance T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312990580; 6045586 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Valerio, L AU - Blancafort, J AU - Valencia, A AU - Mensa, X Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Drugs KW - Computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312990580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Computational+Modeling+for+Qt+Prolongation%3A+A+Drug+Cardiovascular+Safety+Endpoint+of+Paramount+Importance&rft.au=Valerio%2C+L%3BBlancafort%2C+J%3BValencia%2C+A%3BMensa%2C+X&rft.aulast=Valerio&rft.aufirst=L&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of Relative Rosiglitazone, Pioglitazone, and Epirubicin Cardiotoxicity in Rats Using Historical Microarray Data T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312990541; 6045585 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Zhou, H AU - Colatsky, T Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Historical account KW - Rats KW - Data processing KW - Epirubicin KW - pioglitazone KW - rosiglitazone UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312990541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Analysis+of+Relative+Rosiglitazone%2C+Pioglitazone%2C+and+Epirubicin+Cardiotoxicity+in+Rats+Using+Historical+Microarray+Data&rft.au=Zhou%2C+H%3BColatsky%2C+T&rft.aulast=Zhou&rft.aufirst=H&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Critical Cysteine Residues of KEAP1 in Suppression of NRF2 Basal Activity and Arsenic-Sensing by Regulating the Ubiquitination-Proteasomal Degradation of NRF2 Protein T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312987134; 6045850 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - He, X. AU - Ma, Q. Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Degradation KW - Residues KW - Cysteine KW - NRF2 protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312987134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Critical+Cysteine+Residues+of+KEAP1+in+Suppression+of+NRF2+Basal+Activity+and+Arsenic-Sensing+by+Regulating+the+Ubiquitination-Proteasomal+Degradation+of+NRF2+Protein&rft.au=He%2C+X.%3BMa%2C+Q.&rft.aulast=He&rft.aufirst=X.&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Ketamine Induces Motor Neuron Toxicity and Attenuation of Heart Rate in Zebrafish T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312986710; 6047049 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kanungo, J AU - Cuevas, E AU - He, Z He AU - Ali, S AU - Paule, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - heart rate KW - Heart rate KW - Motor neurons KW - Ketamine KW - Freshwater fish KW - Neurons KW - Danio rerio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Ketamine+Induces+Motor+Neuron+Toxicity+and+Attenuation+of+Heart+Rate+in+Zebrafish&rft.au=Kanungo%2C+J%3BCuevas%2C+E%3BHe%2C+Z+He%3BAli%2C+S%3BPaule%2C+M&rft.aulast=Kanungo&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Identifying Oncomutations That Will Be Useful Quantitative Biomarkers of Carcinogenic Effect Suitable for Subchronic Toxicity Testing T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312986586; 6045679 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Myers, M AU - Wang, Y AU - Meng, F AU - McKinzie, P AU - McKim, K AU - Parsons, B Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity testing KW - Bioindicators KW - toxicity testing KW - Carcinogenicity KW - biomarkers KW - Bioaccumulation KW - Pollution indicators KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Identifying+Oncomutations+That+Will+Be+Useful+Quantitative+Biomarkers+of+Carcinogenic+Effect+Suitable+for+Subchronic+Toxicity+Testing&rft.au=Myers%2C+M%3BWang%2C+Y%3BMeng%2C+F%3BMcKinzie%2C+P%3BMcKim%2C+K%3BParsons%2C+B&rft.aulast=Myers&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Association between the Design, Contents, Emissions, Use, and Biomarkers of Exposure from Tobacco Products T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312984860; 6048132 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Ashley, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bioindicators KW - Tobacco KW - Emissions KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Association+between+the+Design%2C+Contents%2C+Emissions%2C+Use%2C+and+Biomarkers+of+Exposure+from+Tobacco+Products&rft.au=Ashley%2C+D&rft.aulast=Ashley&rft.aufirst=D&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epigenetic Inactivation of p16ink4a Gene Is Associated with Resistance of Guerin Carcinomas to Doxorubicin and Cisplatin T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312982500; 6045544 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Sarfaraz, S AU - Shpyleva, S AU - Todor, I AU - Yanova, N AU - Chekhun, V AU - Pogribny, I Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - inactivation KW - Cisplatin KW - INK4a protein KW - Doxorubicin KW - epigenetics KW - Carcinoma KW - p16 protein KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312982500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Epigenetic+Inactivation+of+p16ink4a+Gene+Is+Associated+with+Resistance+of+Guerin+Carcinomas+to+Doxorubicin+and+Cisplatin&rft.au=Sarfaraz%2C+S%3BShpyleva%2C+S%3BTodor%2C+I%3BYanova%2C+N%3BChekhun%2C+V%3BPogribny%2C+I&rft.aulast=Sarfaraz&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Molecular Pathways of Pulmonary Inflammation Following Aspiration and Inhalation of Stainless Steel Welding Fume in Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312979251; 6047758 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Zeidler-Erdely, P AU - Erdely, A AU - Kashon, M AU - Li, S. AU - Antonini, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Welding KW - Steel KW - Fumes KW - Inhalation KW - Mice KW - Lung KW - stainless steel KW - Inflammation KW - Stainless steel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Molecular+Pathways+of+Pulmonary+Inflammation+Following+Aspiration+and+Inhalation+of+Stainless+Steel+Welding+Fume+in+Mice&rft.au=Zeidler-Erdely%2C+P%3BErdely%2C+A%3BKashon%2C+M%3BLi%2C+S.%3BAntonini%2C+J&rft.aulast=Zeidler-Erdely&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Peripheral Blood Gene Expression Profiling Reveals Silica-Induced Pulmonary Toxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312979071; 6047754 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Roberts, J AU - Joseph, P AU - Sellamuthu, R AU - Umbright, C AU - Chapman, R AU - Young, S AU - Richardson, D AU - Leonard, D AU - McKinney, W AU - Chen, B AU - Frazer, D AU - Li, S. AU - Kashon, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Gene expression KW - Lung KW - Peripheral blood KW - Profiling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312979071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Peripheral+Blood+Gene+Expression+Profiling+Reveals+Silica-Induced+Pulmonary+Toxicity&rft.au=Roberts%2C+J%3BJoseph%2C+P%3BSellamuthu%2C+R%3BUmbright%2C+C%3BChapman%2C+R%3BYoung%2C+S%3BRichardson%2C+D%3BLeonard%2C+D%3BMcKinney%2C+W%3BChen%2C+B%3BFrazer%2C+D%3BLi%2C+S.%3BKashon%2C+M&rft.aulast=Roberts&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Propentofylline Attenuates Methamphetamine-Induced Dopamine Release in the Rat Caudate-Putamen T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312978122; 6045944 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Binienda, Z AU - Gough, B AU - Pereira, F AU - Ali, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - propentofylline KW - Caudate-putamen KW - Dopamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312978122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Propentofylline+Attenuates+Methamphetamine-Induced+Dopamine+Release+in+the+Rat+Caudate-Putamen&rft.au=Binienda%2C+Z%3BGough%2C+B%3BPereira%2C+F%3BAli%2C+S&rft.aulast=Binienda&rft.aufirst=Z&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Significant Relationship Exists between Oral Drug Exposure Level and Its Potential Risk for Human Hepatotoxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312977671; 6045874 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chen, M AU - Vijay, V AU - Tong, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - hepatotoxicity KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Significant+Relationship+Exists+between+Oral+Drug+Exposure+Level+and+Its+Potential+Risk+for+Human+Hepatotoxicity&rft.au=Chen%2C+M%3BVijay%2C+V%3BTong%2C+W&rft.aulast=Chen&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Adjuvant Effect Of 1C3-? -Glucan (Zymosan) Exposure in a Mouse Ovalbumin Allergy Model T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312976422; 6047761 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Young, S AU - Roberts, J AU - Antonini, J AU - Wolfarth, M AU - Kashon, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Ovalbumin KW - Hypersensitivity KW - Adjuvants KW - Albumin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Adjuvant+Effect+Of+1C3-%3F+-Glucan+%28Zymosan%29+Exposure+in+a+Mouse+Ovalbumin+Allergy+Model&rft.au=Young%2C+S%3BRoberts%2C+J%3BAntonini%2C+J%3BWolfarth%2C+M%3BKashon%2C+M&rft.aulast=Young&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Individual and Interactive Effects of Lipopolysaccharide and Deoxynivalenol on Free Fatty Acids in the Liver and Brain of Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312973516; 6045954 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Ross, I AU - Boyle, T AU - Johnson, W AU - Garthof, L AU - Ahn, S AU - O'Donnel, M AU - Kim, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Brain KW - Fatty acids KW - Liver KW - Rats KW - Lipopolysaccharides KW - Deoxynivalenol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312973516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Individual+and+Interactive+Effects+of+Lipopolysaccharide+and+Deoxynivalenol+on+Free+Fatty+Acids+in+the+Liver+and+Brain+of+Rats&rft.au=Ross%2C+I%3BBoyle%2C+T%3BJohnson%2C+W%3BGarthof%2C+L%3BAhn%2C+S%3BO%27Donnel%2C+M%3BKim%2C+C&rft.aulast=Ross&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Pros and Cons of Using Databases to Support Toxicological Decision Making T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312969072; 6046975 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Allio, T Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Databases KW - Decision making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=The+Pros+and+Cons+of+Using+Databases+to+Support+Toxicological+Decision+Making&rft.au=Allio%2C+T&rft.aulast=Allio&rft.aufirst=T&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Surface Modification on the Bioavailability and Inflammatory Potential of Multi-Walled Carbon Nanotubes T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312967781; 6046616 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Sager, T AU - Wolfarth, M AU - Porter, D AU - Castranova, V AU - Wu, N. AU - Holian, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - nanotechnology KW - Bioavailability KW - Carbon KW - Inflammation KW - nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Effect+of+Surface+Modification+on+the+Bioavailability+and+Inflammatory+Potential+of+Multi-Walled+Carbon+Nanotubes&rft.au=Sager%2C+T%3BWolfarth%2C+M%3BPorter%2C+D%3BCastranova%2C+V%3BWu%2C+N.%3BHolian%2C+A&rft.aulast=Sager&rft.aufirst=T&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Kava Extract, an Herbal Alternative for Anxiety Relief, Potentiates Acetaminopheninduced Cytotoxicity in Rat Hepatic Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312965948; 6045893 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Yang, X AU - Salminen, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cytotoxicity KW - Anxiety KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312965948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Kava+Extract%2C+an+Herbal+Alternative+for+Anxiety+Relief%2C+Potentiates+Acetaminopheninduced+Cytotoxicity+in+Rat+Hepatic+Cells&rft.au=Yang%2C+X%3BSalminen%2C+W&rft.aulast=Yang&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Acrylamide and Glycidamide Are Mutagenic in Spermatogonial Stem Cells of Big Blue Mice T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312961888; 6045508 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Mei, N AU - Wang, R AU - McDaniel, L AU - Shelton, S AU - Doerge, D AU - Manjanatha, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - stem cells KW - Mice KW - Acrylamide KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Acrylamide+and+Glycidamide+Are+Mutagenic+in+Spermatogonial+Stem+Cells+of+Big+Blue+Mice&rft.au=Mei%2C+N%3BWang%2C+R%3BMcDaniel%2C+L%3BShelton%2C+S%3BDoerge%2C+D%3BManjanatha%2C+M&rft.aulast=Mei&rft.aufirst=N&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Mechanistic Studies on the Cytotoxicity of Leflunomide and Its Major Metabolites in Rat Hepatic Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312959507; 6045871 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Shi, Q AU - Yang, X AU - Salminen, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cytotoxicity KW - Metabolites KW - leflunomide KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312959507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Mechanistic+Studies+on+the+Cytotoxicity+of+Leflunomide+and+Its+Major+Metabolites+in+Rat+Hepatic+Cells&rft.au=Shi%2C+Q%3BYang%2C+X%3BSalminen%2C+W&rft.aulast=Shi&rft.aufirst=Q&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Copper Nanoparticles Induce Cerebral Microvasculature Proliferation or Toxicity That Affect Blood-Brain Barrier Permeability T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312958843; 6046900 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Trickler, W AU - Lantz, S AU - Robinson, B AU - Newport, G AU - Howard, P AU - Schlager, J AU - Paule, M AU - Slikker, W AU - Hussain, S AU - Ali, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Copper KW - Membrane permeability KW - Microvasculature KW - nanoparticles KW - Blood-brain barrier KW - Circulatory system UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Copper+Nanoparticles+Induce+Cerebral+Microvasculature+Proliferation+or+Toxicity+That+Affect+Blood-Brain+Barrier+Permeability&rft.au=Trickler%2C+W%3BLantz%2C+S%3BRobinson%2C+B%3BNewport%2C+G%3BHoward%2C+P%3BSchlager%2C+J%3BPaule%2C+M%3BSlikker%2C+W%3BHussain%2C+S%3BAli%2C+S&rft.aulast=Trickler&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quantitative Assessment of [18F]-DFNSH Uptake by Micropet Imaging as a Biomarker of Anesthetic-Induced Neuronal Death T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312958722; 6047096 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Zhang, X AU - Wang, C AU - Newport, G AU - Paule, M AU - Liu, F AU - Berridge, M AU - Apana, S AU - Kabalka, G AU - Slikker, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bioindicators KW - Mortality KW - biomarkers KW - Biomarkers KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312958722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Quantitative+Assessment+of+%5B18F%5D-DFNSH+Uptake+by+Micropet+Imaging+as+a+Biomarker+of+Anesthetic-Induced+Neuronal+Death&rft.au=Zhang%2C+X%3BWang%2C+C%3BNewport%2C+G%3BPaule%2C+M%3BLiu%2C+F%3BBerridge%2C+M%3BApana%2C+S%3BKabalka%2C+G%3BSlikker%2C+W&rft.aulast=Zhang&rft.aufirst=X&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of Whole Genome Amplified (WGA) DNA for Use in Genotyping Assay Development T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312957452; 6046805 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Han, T AU - Chang, C AU - Kwekel, J AU - Chen, Y AU - Martinez-Murillo, F AU - Roscoe, D AU - Tezak, Z AU - Philip, R AU - Bijwaard, K AU - Fuscoe, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Genomes KW - Genotyping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Characterization+of+Whole+Genome+Amplified+%28WGA%29+DNA+for+Use+in+Genotyping+Assay+Development&rft.au=Han%2C+T%3BChang%2C+C%3BKwekel%2C+J%3BChen%2C+Y%3BMartinez-Murillo%2C+F%3BRoscoe%2C+D%3BTezak%2C+Z%3BPhilip%2C+R%3BBijwaard%2C+K%3BFuscoe%2C+J&rft.aulast=Han&rft.aufirst=T&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Association of Genetic Variations in Antioxidant Enzyme Genes with Diisocyanate-Induced Asthma in Exposed Workers T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312957384; 6046803 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Yucesoy, B AU - Johnson, V AU - Fluharty, K AU - Slaven, J AU - Lummus, Z AU - Kissling, G AU - Germolec, D AU - Luster, M AU - Bernstein, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Respiratory diseases KW - Asthma KW - Occupational exposure KW - genetic diversity KW - Enzymes KW - Antioxidants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312957384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Association+of+Genetic+Variations+in+Antioxidant+Enzyme+Genes+with+Diisocyanate-Induced+Asthma+in+Exposed+Workers&rft.au=Yucesoy%2C+B%3BJohnson%2C+V%3BFluharty%2C+K%3BSlaven%2C+J%3BLummus%2C+Z%3BKissling%2C+G%3BGermolec%2C+D%3BLuster%2C+M%3BBernstein%2C+D&rft.aulast=Yucesoy&rft.aufirst=B&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Putting Workers' Safety and Health into Green Chemistry T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312956920; 6046348 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Schulte, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Green development KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Putting+Workers%27+Safety+and+Health+into+Green+Chemistry&rft.au=Schulte%2C+P&rft.aulast=Schulte&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Whole Body Inhalation Exposure System for the Oil Dispersant Corexit 9500 with Pulmonary Function Results from an Initial Set of Exposures with Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312956317; 6047774 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Goldsmith, W AU - McKinney, W AU - Jackson, M AU - Reynolds, J AU - Cumpston, J AU - Frazer, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Respiratory function KW - Oil KW - Inhalation KW - Rats KW - Dispersants KW - Lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312956317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=A+Whole+Body+Inhalation+Exposure+System+for+the+Oil+Dispersant+Corexit+9500+with+Pulmonary+Function+Results+from+an+Initial+Set+of+Exposures+with+Rats&rft.au=Goldsmith%2C+W%3BMcKinney%2C+W%3BJackson%2C+M%3BReynolds%2C+J%3BCumpston%2C+J%3BFrazer%2C+D&rft.aulast=Goldsmith&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of Direct and Indirect Dna Damage Induced by Ochratoxin a in Cho and tk6 Cells Using the Comet Assay T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312955832; 6045760 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Ali, R AU - Shaddock, J AU - Ding, W AU - Bhalli, J AU - Khan, Q AU - Heflich, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - ochratoxin A KW - Ochratoxin A KW - Comet assay KW - DNA damage KW - Toxicity testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Evaluation+of+Direct+and+Indirect+Dna+Damage+Induced+by+Ochratoxin+a+in+Cho+and+tk6+Cells+Using+the+Comet+Assay&rft.au=Ali%2C+R%3BShaddock%2C+J%3BDing%2C+W%3BBhalli%2C+J%3BKhan%2C+Q%3BHeflich%2C+R&rft.aulast=Ali&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Midazolam-Induced Changes in Gene Expression in Postnatal Rat Pup Brain T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312955829; 6048033 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Guo, L AU - Sadovova, N AU - Paule, M AU - Slikker, W AU - Liu, F AU - Rainosek, S AU - Zhang, J AU - Shi, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Brain KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Midazolam-Induced+Changes+in+Gene+Expression+in+Postnatal+Rat+Pup+Brain&rft.au=Guo%2C+L%3BSadovova%2C+N%3BPaule%2C+M%3BSlikker%2C+W%3BLiu%2C+F%3BRainosek%2C+S%3BZhang%2C+J%3BShi%2C+L&rft.aulast=Guo&rft.aufirst=L&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Gene Expression in Ketamine-Exposed Rat Brain T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312955758; 6048032 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Wang, C AU - Guo, L AU - Patterson, T AU - Sadovova, N AU - Hanig, J AU - Shi, Q AU - Dial, S AU - Li, Q. AU - Zhang, X Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Brain KW - Gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Gene+Expression+in+Ketamine-Exposed+Rat+Brain&rft.au=Wang%2C+C%3BGuo%2C+L%3BPatterson%2C+T%3BSadovova%2C+N%3BHanig%2C+J%3BShi%2C+Q%3BDial%2C+S%3BLi%2C+Q.%3BZhang%2C+X&rft.aulast=Wang&rft.aufirst=C&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Subcellular Distribution of Gold Nanoparticles and Lack of Cytotoxicity in Rat Primary Hepatocyte Cell Culture Model T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312954129; 6047610 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Zhang, Y AU - Salminen, W AU - Shi, Q AU - Yang, X AU - Howard, P AU - Jones, Y AU - Linder, S AU - Mudalige, T AU - Miller, B AU - Weis, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cytotoxicity KW - Cell culture KW - Hepatocytes KW - nanoparticles KW - Gold UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312954129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Subcellular+Distribution+of+Gold+Nanoparticles+and+Lack+of+Cytotoxicity+in+Rat+Primary+Hepatocyte+Cell+Culture+Model&rft.au=Zhang%2C+Y%3BSalminen%2C+W%3BShi%2C+Q%3BYang%2C+X%3BHoward%2C+P%3BJones%2C+Y%3BLinder%2C+S%3BMudalige%2C+T%3BMiller%2C+B%3BWeis%2C+C&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - An in Vitro Model System for Assessing the Effects of Oil Dispersants in Human Hepatocytes T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312952647; 6047012 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Bandele, O AU - Santillo, M AU - Wiesenfeld, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Oil KW - Dispersants KW - Hepatocytes KW - Pollution effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312952647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=An+in+Vitro+Model+System+for+Assessing+the+Effects+of+Oil+Dispersants+in+Human+Hepatocytes&rft.au=Bandele%2C+O%3BSantillo%2C+M%3BWiesenfeld%2C+P&rft.aulast=Bandele&rft.aufirst=O&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of a Quantitative Immunohistochemical Method for Diagnosing Phospholipidosis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312951437; 6046888 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Haskins, K AU - Stewart, S AU - Mans, D AU - Zhang, J AU - Peters, D AU - Colatsky, T AU - Thompson, K Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312951437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Use+of+a+Quantitative+Immunohistochemical+Method+for+Diagnosing+Phospholipidosis&rft.au=Haskins%2C+K%3BStewart%2C+S%3BMans%2C+D%3BZhang%2C+J%3BPeters%2C+D%3BColatsky%2C+T%3BThompson%2C+K&rft.aulast=Haskins&rft.aufirst=K&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Biodegradable Materials for Tissue Engineering: Applications and Safety Assessment T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312947902; 6045441 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Brown, R AU - Hutchinson, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Safety engineering KW - Biodegradation KW - Biodegradability KW - Tissue engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312947902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Biodegradable+Materials+for+Tissue+Engineering%3A+Applications+and+Safety+Assessment&rft.au=Brown%2C+R%3BHutchinson%2C+R&rft.aulast=Brown&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Stabilizing Effects of Ph, Galactose, and Exopolysaccharides on Thermal Inactivation of Ricin in Foods T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312938931; 6047867 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Tolleson, W AU - Triplett, O AU - Jackson, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - inactivation KW - pH KW - Ricin KW - exopolysaccharides KW - Food KW - Galactose KW - Temperature effects KW - Stabilizing KW - Abiotic factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312938931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Stabilizing+Effects+of+Ph%2C+Galactose%2C+and+Exopolysaccharides+on+Thermal+Inactivation+of+Ricin+in+Foods&rft.au=Tolleson%2C+W%3BTriplett%2C+O%3BJackson%2C+L&rft.aulast=Tolleson&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Matrix Metalloproteinases 2 and 9 and Tissue Inhibitors of Metalloproteinase 1 in Cerium Oxide Induced Pulmonary Fibrosis T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312931902; 6047517 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Castranova, V AU - Ma, J. AU - Mercer, R AU - Barger, M Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cerium KW - Fibrosis KW - Tissue inhibitor of metalloproteinase 1 KW - Lung diseases KW - oxides KW - Matrix metalloproteinase KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Matrix+Metalloproteinases+2+and+9+and+Tissue+Inhibitors+of+Metalloproteinase+1+in+Cerium+Oxide+Induced+Pulmonary+Fibrosis&rft.au=Castranova%2C+V%3BMa%2C+J.%3BMercer%2C+R%3BBarger%2C+M&rft.aulast=Castranova&rft.aufirst=V&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pulmonary Toxicity Following Intratracheal Instillation of Dispersed Silver Nanoparticles in Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312931364; 6047195 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Roberts, J AU - Young, S AU - Antonini, J AU - Chapman, R AU - Kenyon, A AU - Schwegler-Berry, D AU - Stefaniak, A AU - Chen, B Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Silver KW - Rats KW - Trachea KW - Lung KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Pulmonary+Toxicity+Following+Intratracheal+Instillation+of+Dispersed+Silver+Nanoparticles+in+Rats&rft.au=Roberts%2C+J%3BYoung%2C+S%3BAntonini%2C+J%3BChapman%2C+R%3BKenyon%2C+A%3BSchwegler-Berry%2C+D%3BStefaniak%2C+A%3BChen%2C+B&rft.aulast=Roberts&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Considerations When Managing Seizures in Drug Development T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312930949; 6047244 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Avila, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Drug development KW - Seizures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Considerations+When+Managing+Seizures+in+Drug+Development&rft.au=Avila%2C+A&rft.aulast=Avila&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Mycotoxins: U.S., Canadian, European, and Jecfa Regulatory Strategies T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312929901; 6046969 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Henry, S Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - USA KW - Mycotoxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312929901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Mycotoxins%3A+U.S.%2C+Canadian%2C+European%2C+and+Jecfa+Regulatory+Strategies&rft.au=Henry%2C+S&rft.aulast=Henry&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of Bisphenol a Kinetics and Metabolism in Neonatal and Adult Monkeys and Rats Using a Pbpk Model T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312925487; 6046144 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Fisher, J AU - Twaddle, N AU - Vanlandingham, M AU - Doerge, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Kinetics KW - bisphenol A KW - Metabolism KW - Neonates KW - Rats KW - Bisphenol A UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312925487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Analysis+of+Bisphenol+a+Kinetics+and+Metabolism+in+Neonatal+and+Adult+Monkeys+and+Rats+Using+a+Pbpk+Model&rft.au=Fisher%2C+J%3BTwaddle%2C+N%3BVanlandingham%2C+M%3BDoerge%2C+D&rft.aulast=Fisher&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Collaborative Project for Data Sharing and Harmonization of Developmental Toxicity Databases T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312925253; 6045933 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Busta, E AU - Espada, S AU - Martin, M AU - Hristozov, D AU - Arvidson, K AU - Mattison, D AU - Yang, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Data processing KW - Databases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312925253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=A+Collaborative+Project+for+Data+Sharing+and+Harmonization+of+Developmental+Toxicity+Databases&rft.au=Busta%2C+E%3BEspada%2C+S%3BMartin%2C+M%3BHristozov%2C+D%3BArvidson%2C+K%3BMattison%2C+D%3BYang%2C+C&rft.aulast=Busta&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of Welding Aerosols Generated by Resistance Spot Welding T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312922960; 6045999 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Afshari, A AU - Chen, B AU - Schwegler-Berry, D AU - Cumpston, J AU - Cumpston, A AU - Leonard, D AU - Friend, S AU - Zeidler-Erdely, P AU - Frazer, D AU - Antonini, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Welding KW - Aerosols UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312922960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Characterization+of+Welding+Aerosols+Generated+by+Resistance+Spot+Welding&rft.au=Afshari%2C+A%3BChen%2C+B%3BSchwegler-Berry%2C+D%3BCumpston%2C+J%3BCumpston%2C+A%3BLeonard%2C+D%3BFriend%2C+S%3BZeidler-Erdely%2C+P%3BFrazer%2C+D%3BAntonini%2C+J&rft.aulast=Afshari&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Thoracic Damping and the Relationship between Penh of the Thoracic Air-Flow (It ) and Tidal Midexpiratory Flow (EF 50 ) T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312922370; 6047735 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Frazer, D AU - Reynolds, J AU - Goldsmith, W AU - McKinney, W AU - Jackson, M AU - Afshari, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Thorax KW - Damping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312922370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Thoracic+Damping+and+the+Relationship+between+Penh+of+the+Thoracic+Air-Flow+%28It+%29+and+Tidal+Midexpiratory+Flow+%28EF+50+%29&rft.au=Frazer%2C+D%3BReynolds%2C+J%3BGoldsmith%2C+W%3BMcKinney%2C+W%3BJackson%2C+M%3BAfshari%2C+A&rft.aulast=Frazer&rft.aufirst=D&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Impaired Performance on an Operant Learning Task During Lifetime Exposure to Acrylamide in Fischer 344 Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312918553; 6048044 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Paule, M AU - Garey, J AU - Roegge, C Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Rats KW - Operant conditioning KW - Acrylamide KW - Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312918553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Impaired+Performance+on+an+Operant+Learning+Task+During+Lifetime+Exposure+to+Acrylamide+in+Fischer+344+Rats&rft.au=Paule%2C+M%3BGarey%2C+J%3BRoegge%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Gold Nanoparticles Increase the Liver Toxicity of Acetaminophen T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312914393; 6047510 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Stewart, S AU - Rouse, R AU - Keene, A AU - Knapton, A AU - Hartman, N AU - Peters, D AU - Tobin, G AU - Zhang, L AU - Xu, L. AU - Tyner, K Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Liver KW - nanoparticles KW - Gold KW - Acetaminophen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312914393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Gold+Nanoparticles+Increase+the+Liver+Toxicity+of+Acetaminophen&rft.au=Stewart%2C+S%3BRouse%2C+R%3BKeene%2C+A%3BKnapton%2C+A%3BHartman%2C+N%3BPeters%2C+D%3BTobin%2C+G%3BZhang%2C+L%3BXu%2C+L.%3BTyner%2C+K&rft.aulast=Stewart&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Iron Oxide Nanoparticles Cause Oxidative Stress and Dermal Toxicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312914264; 6047508 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Murray, A AU - Waltz, M AU - Castranova, V AU - Fadeel, B AU - Riviere, J AU - Kagan, V AU - Monteiro-Riviere, N AU - Shvedova, A AU - Kisin, E AU - Inman, A AU - Young, S AU - Muhammed, M AU - Burks, T AU - Uheida, A AU - Tkach, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Iron oxides KW - oxidative stress KW - Oxidative stress KW - iron oxides KW - Skin KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312914264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Iron+Oxide+Nanoparticles+Cause+Oxidative+Stress+and+Dermal+Toxicity&rft.au=Murray%2C+A%3BWaltz%2C+M%3BCastranova%2C+V%3BFadeel%2C+B%3BRiviere%2C+J%3BKagan%2C+V%3BMonteiro-Riviere%2C+N%3BShvedova%2C+A%3BKisin%2C+E%3BInman%2C+A%3BYoung%2C+S%3BMuhammed%2C+M%3BBurks%2C+T%3BUheida%2C+A%3BTkach%2C+A&rft.aulast=Murray&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Genotoxity of Furan in F344 Rats Using the in Vivo Comet and Micronucleus Assays T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312911884; 6046983 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Ding, W AU - Heflich, R AU - Pearce, M AU - White, G AU - Mittelstaedt, R AU - Shaddock, J AU - McDaniel, P AU - Doerge, D AU - Manjanatha, M AU - Aidoo, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Furans KW - Rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Genotoxity+of+Furan+in+F344+Rats+Using+the+in+Vivo+Comet+and+Micronucleus+Assays&rft.au=Ding%2C+W%3BHeflich%2C+R%3BPearce%2C+M%3BWhite%2C+G%3BMittelstaedt%2C+R%3BShaddock%2C+J%3BMcDaniel%2C+P%3BDoerge%2C+D%3BManjanatha%2C+M%3BAidoo%2C+A&rft.aulast=Ding&rft.aufirst=W&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - MIR-34A Expression Was up-Regulated by Seven Different Genotoxic Agents in a Dosedependent Manner in TK6 Cells T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312911331; 6046865 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Li, Z. AU - Yan, J AU - Chen, T Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Genotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=MIR-34A+Expression+Was+up-Regulated+by+Seven+Different+Genotoxic+Agents+in+a+Dosedependent+Manner+in+TK6+Cells&rft.au=Li%2C+Z.%3BYan%2C+J%3BChen%2C+T&rft.aulast=Li&rft.aufirst=Z.&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of a Test Method for the Measurement of the Urinary Biomarkers Sbenzylmercapturic Acid and Sphenylmercapturic Acid T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312911317; 6046864 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - B'Hymer, C AU - Snawder, J Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bioindicators KW - Urine KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Evaluation+of+a+Test+Method+for+the+Measurement+of+the+Urinary+Biomarkers+Sbenzylmercapturic+Acid+and+Sphenylmercapturic+Acid&rft.au=B%27Hymer%2C+C%3BSnawder%2C+J&rft.aulast=B%27Hymer&rft.aufirst=C&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Serum Levels of the Phospholipid Bis(MONOACYLGLYCEROL) Phosphate as an Indicator of Phospholipidosis Induced in the Rat by Coralgil T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312911260; 6046862 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Thompson, K AU - Haskins, K AU - Hartman, N AU - Rosenzweig, B AU - Stewart, S AU - Peters, D AU - Mans, D AU - Colatsky, T Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Phosphate KW - Phospholipids KW - Serum levels KW - Corals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312911260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Serum+Levels+of+the+Phospholipid+Bis%28MONOACYLGLYCEROL%29+Phosphate+as+an+Indicator+of+Phospholipidosis+Induced+in+the+Rat+by+Coralgil&rft.au=Thompson%2C+K%3BHaskins%2C+K%3BHartman%2C+N%3BRosenzweig%2C+B%3BStewart%2C+S%3BPeters%2C+D%3BMans%2C+D%3BColatsky%2C+T&rft.aulast=Thompson&rft.aufirst=K&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Multi-Wall Carbon Nanotube (MWCNT)- Induced Gene Expression in the Mouse Lung: Implication of Carcinogenesis Risk T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312910475; 6046623 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Pacurari, M AU - Qian, Y AU - Hubbs, A AU - Porter, D AU - Wolfarth, M AU - Luo, D AU - Wan, Y AU - Castranova, V AU - Guo, N Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - nanotechnology KW - Carcinogenesis KW - Gene expression KW - Carbon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312910475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Multi-Wall+Carbon+Nanotube+%28MWCNT%29-+Induced+Gene+Expression+in+the+Mouse+Lung%3A+Implication+of+Carcinogenesis+Risk&rft.au=Pacurari%2C+M%3BQian%2C+Y%3BHubbs%2C+A%3BPorter%2C+D%3BWolfarth%2C+M%3BLuo%2C+D%3BWan%2C+Y%3BCastranova%2C+V%3BGuo%2C+N&rft.aulast=Pacurari&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Assessment of Fibrogenic Biomarkers Induced by Multi Wall Carbon Nanotubes T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312910399; 6046621 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Mishra, A AU - Rojanasakul, Y AU - Castranova, V AU - Mercer, R AU - Wang, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bioindicators KW - nanotechnology KW - Carbon KW - nanotubes KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312910399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Assessment+of+Fibrogenic+Biomarkers+Induced+by+Multi+Wall+Carbon+Nanotubes&rft.au=Mishra%2C+A%3BRojanasakul%2C+Y%3BCastranova%2C+V%3BMercer%2C+R%3BWang%2C+L&rft.aulast=Mishra&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Plasma, Urine, and Tissue Concentrations of Hexavalent Chromium Associated Acute Kidney Injury in Sprague-Dawley Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312909430; 6046191 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Brown, R AU - Zhang, Q AU - Barber, D AU - Komiyama, A AU - Goering, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Kidneys KW - Injuries KW - Urine KW - Rats KW - Chromium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312909430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Plasma%2C+Urine%2C+and+Tissue+Concentrations+of+Hexavalent+Chromium+Associated+Acute+Kidney+Injury+in+Sprague-Dawley+Rats&rft.au=Brown%2C+R%3BZhang%2C+Q%3BBarber%2C+D%3BKomiyama%2C+A%3BGoering%2C+P&rft.aulast=Brown&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Ionizing Radiation on K- Ras Codon 12 Point Mutations in Lung and Liver of the F344 Rat T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312908102; 6046316 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - McKinzie, P AU - Shaddock, J AU - Pearce, M AU - Dobrovolsky, V Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - Point mutation KW - Ionizing radiation KW - Liver KW - Codons KW - Ras protein KW - RAS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312908102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Effect+of+Ionizing+Radiation+on+K-+Ras+Codon+12+Point+Mutations+in+Lung+and+Liver+of+the+F344+Rat&rft.au=McKinzie%2C+P%3BShaddock%2C+J%3BPearce%2C+M%3BDobrovolsky%2C+V&rft.aulast=McKinzie&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Interferon Signaling, Systemic Inflammation, and Atherosclerosis Following Welding Fume Inhalation Exposure: From the Lung to the Blood to the Vasculature T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312907634; 6045625 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Erdely, A AU - Hulderman, T AU - Liston, A AU - Salmen-Muniz, R AU - Stone, S AU - Chen, B AU - Frazer, D AU - Li, S. AU - Kashon, M AU - Antonini, J AU - Simeonova, P AU - Zeidler-Erdely, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - Welding KW - Inhalation KW - Fumes KW - Blood KW - Interferon KW - Arteriosclerosis KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312907634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Interferon+Signaling%2C+Systemic+Inflammation%2C+and+Atherosclerosis+Following+Welding+Fume+Inhalation+Exposure%3A+From+the+Lung+to+the+Blood+to+the+Vasculature&rft.au=Erdely%2C+A%3BHulderman%2C+T%3BListon%2C+A%3BSalmen-Muniz%2C+R%3BStone%2C+S%3BChen%2C+B%3BFrazer%2C+D%3BLi%2C+S.%3BKashon%2C+M%3BAntonini%2C+J%3BSimeonova%2C+P%3BZeidler-Erdely%2C+P&rft.aulast=Erdely&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Prediction of Drug-Induced Liver Injury in Humans with Toxicogenomics T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312906863; 6045578 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Zhang, M AU - Shi, Q AU - Chen, M AU - Tong, W Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Injuries KW - Liver KW - Toxicity KW - Animal physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Prediction+of+Drug-Induced+Liver+Injury+in+Humans+with+Toxicogenomics&rft.au=Zhang%2C+M%3BShi%2C+Q%3BChen%2C+M%3BTong%2C+W&rft.aulast=Zhang&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Nanoparticle Inhalation Enhances Cardiac Protein Phosphorylation and Neurotransmitter Synthesis in the Nodose Ganglia of Rats T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905448; 6046895 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kan, H AU - Wu, Z. AU - Young, S AU - Chen, T AU - Cumpston, J AU - Chen, F AU - Castranova, V Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Inhalation KW - Rats KW - Neurotransmitters KW - nodose ganglion KW - Heart KW - nanoparticles KW - Phosphorylation KW - Ganglia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Nanoparticle+Inhalation+Enhances+Cardiac+Protein+Phosphorylation+and+Neurotransmitter+Synthesis+in+the+Nodose+Ganglia+of+Rats&rft.au=Kan%2C+H%3BWu%2C+Z.%3BYoung%2C+S%3BChen%2C+T%3BCumpston%2C+J%3BChen%2C+F%3BCastranova%2C+V&rft.aulast=Kan&rft.aufirst=H&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Determination of Bisphenol-a Compounds Leachable from Polycarbonate- and Polysulfone-Based Hemodialyzers T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905415; 6046751 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Guo, J AU - Cho, S AU - Luu, H Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Bisphenol A UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Determination+of+Bisphenol-a+Compounds+Leachable+from+Polycarbonate-+and+Polysulfone-Based+Hemodialyzers&rft.au=Guo%2C+J%3BCho%2C+S%3BLuu%2C+H&rft.aulast=Guo&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Rapid Toxicity Screening of Polymeric Materials Using the Microtox Assay T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905337; 6046749 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kulkarni, P AU - Dinesdurage, H AU - Brown, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Microtox KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Rapid+Toxicity+Screening+of+Polymeric+Materials+Using+the+Microtox+Assay&rft.au=Kulkarni%2C+P%3BDinesdurage%2C+H%3BBrown%2C+R&rft.aulast=Kulkarni&rft.aufirst=P&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Valuation of the Sensitivity of Endpoints in the Iso 10993-11 Systemic Toxicity Standard Using Positive Control Compounds T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905310; 6046748 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Freeman, A AU - Komiyama, A AU - Fazio, J AU - Hamilla, S AU - Dinesdurage, H AU - Brown, R Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Sensitivity KW - Iso UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Valuation+of+the+Sensitivity+of+Endpoints+in+the+Iso+10993-11+Systemic+Toxicity+Standard+Using+Positive+Control+Compounds&rft.au=Freeman%2C+A%3BKomiyama%2C+A%3BFazio%2C+J%3BHamilla%2C+S%3BDinesdurage%2C+H%3BBrown%2C+R&rft.aulast=Freeman&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pulmonary Inflammation, Epithelial Hyperplasia, and Lymph Node Translocation after Multi-Walled Carbon Nanotube Inhalation T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905232; 6045498 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Hubbs, A AU - Castranova, V AU - Chen, B AU - Frazer, D AU - McKinney, W AU - Mercer, R AU - Kashon, M AU - Battelli, L AU - Willard, P AU - Porter, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - translocation KW - lymph nodes KW - Inhalation KW - nanotechnology KW - Carbon KW - Lymph nodes KW - Lung KW - Hyperplasia KW - Translocation KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Pulmonary+Inflammation%2C+Epithelial+Hyperplasia%2C+and+Lymph+Node+Translocation+after+Multi-Walled+Carbon+Nanotube+Inhalation&rft.au=Hubbs%2C+A%3BCastranova%2C+V%3BChen%2C+B%3BFrazer%2C+D%3BMcKinney%2C+W%3BMercer%2C+R%3BKashon%2C+M%3BBattelli%2C+L%3BWillard%2C+P%3BPorter%2C+D&rft.aulast=Hubbs&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integrating Alternative Test Methods into the Federal Regulatory Framework T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905202; 6046745 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Fitzpatrick, S AU - Schechtman, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Integrating+Alternative+Test+Methods+into+the+Federal+Regulatory+Framework&rft.au=Fitzpatrick%2C+S%3BSchechtman%2C+L&rft.aulast=Fitzpatrick&rft.aufirst=S&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pulmonary Fibrotic Response to Subchronic Multi-Walled Carbon Nanotube Exposure T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312905173; 6045496 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Mercer, R AU - Hubbs, A AU - Scabilloni, J AU - Wang, L AU - Battelli, L AU - Castranova, V AU - Porter, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - nanotechnology KW - Carbon KW - Lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Pulmonary+Fibrotic+Response+to+Subchronic+Multi-Walled+Carbon+Nanotube+Exposure&rft.au=Mercer%2C+R%3BHubbs%2C+A%3BScabilloni%2C+J%3BWang%2C+L%3BBattelli%2C+L%3BCastranova%2C+V%3BPorter%2C+D&rft.aulast=Mercer&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Zidovudine on Mitochondrial Oxidative Phosphorylation Protein Levels and Enzyme Complex Activities T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312904911; 6046740 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Fang, J AU - Beland, F Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Enzymes KW - Mitochondria KW - Oxidative phosphorylation KW - Zidovudine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312904911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Effect+of+Zidovudine+on+Mitochondrial+Oxidative+Phosphorylation+Protein+Levels+and+Enzyme+Complex+Activities&rft.au=Fang%2C+J%3BBeland%2C+F&rft.aulast=Fang&rft.aufirst=J&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Consensus Multiple-Potency Qsar Modeling for Prediction of Rodent Carcinogenicity T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312902917; 6045922 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Matthews, E AU - Cross, K Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Carcinogenicity KW - rodents KW - Structure-activity relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312902917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Consensus+Multiple-Potency+Qsar+Modeling+for+Prediction+of+Rodent+Carcinogenicity&rft.au=Matthews%2C+E%3BCross%2C+K&rft.aulast=Matthews&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Vitro Assessment of Potential Tumorgenicity of Chronic Swcnt and Mwcnt Exposure to Lung Epithelium T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312902485; 6046620 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Stueckle, T AU - Mishra, A AU - Derk, R AU - Rojanasakul, Y AU - Castranova, V AU - Wang, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - Epithelium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312902485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=In+Vitro+Assessment+of+Potential+Tumorgenicity+of+Chronic+Swcnt+and+Mwcnt+Exposure+to+Lung+Epithelium&rft.au=Stueckle%2C+T%3BMishra%2C+A%3BDerk%2C+R%3BRojanasakul%2C+Y%3BCastranova%2C+V%3BWang%2C+L&rft.aulast=Stueckle&rft.aufirst=T&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Elucidation of Factors Determining Carbon Nanotubes' Ability to Penetrate Alveolar Epithelial Barrier and Interact with Lung Fibroblasts in Vitro T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312902453; 6046619 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Derk, R AU - Mishra, A AU - Stueckle, T AU - Rojanasakul, Y AU - Castranova, V AU - Wang, L Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Lung KW - nanotechnology KW - Fibroblasts KW - Carbon KW - Alveoli KW - nanotubes KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312902453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Elucidation+of+Factors+Determining+Carbon+Nanotubes%27+Ability+to+Penetrate+Alveolar+Epithelial+Barrier+and+Interact+with+Lung+Fibroblasts+in+Vitro&rft.au=Derk%2C+R%3BMishra%2C+A%3BStueckle%2C+T%3BRojanasakul%2C+Y%3BCastranova%2C+V%3BWang%2C+L&rft.aulast=Derk&rft.aufirst=R&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Comparative Genotoxicity of Fibrous Particles: Carbon Nanofibers, Single-Walled Carbon Nanotubes, and Asbestos T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312902423; 6046618 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kisin, E AU - Murray, A AU - Sargent, L AU - Lowry, D AU - Siegrist, K AU - Chirila, M AU - Schwegler-Berry, D AU - Leonard, S AU - Castranova, V AU - Fadeel, B AU - Kagan, V AU - Shvedova, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Particulates KW - Genotoxicity KW - nanotechnology KW - Asbestos KW - Carbon KW - nanotubes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312902423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Comparative+Genotoxicity+of+Fibrous+Particles%3A+Carbon+Nanofibers%2C+Single-Walled+Carbon+Nanotubes%2C+and+Asbestos&rft.au=Kisin%2C+E%3BMurray%2C+A%3BSargent%2C+L%3BLowry%2C+D%3BSiegrist%2C+K%3BChirila%2C+M%3BSchwegler-Berry%2C+D%3BLeonard%2C+S%3BCastranova%2C+V%3BFadeel%2C+B%3BKagan%2C+V%3BShvedova%2C+A&rft.aulast=Kisin&rft.aufirst=E&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Chronic Exposure to Glucocorticoids Primes the Cns Proinflammatory Response in Methamphetamine Neurotoxicity. T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312902050; 6045618 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Kelly, K AU - Miller, D AU - James, O Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - methamphetamine KW - Neurotoxicity KW - Central nervous system KW - Glucocorticoids KW - Inflammation KW - Methamphetamine KW - Chronic exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312902050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Chronic+Exposure+to+Glucocorticoids+Primes+the+Cns+Proinflammatory+Response+in+Methamphetamine+Neurotoxicity.&rft.au=Kelly%2C+K%3BMiller%2C+D%3BJames%2C+O&rft.aulast=Kelly&rft.aufirst=K&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Differentiation of Prohaptens from Direct Acting Contact Chemical Allergens Using a Cytochrome P450 Reductase Deficient Mouse Model T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312901961; 6045526 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Chipinda, I AU - Blachere, F AU - Anderson, S AU - Siegel, P Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Cytochromes KW - Allergens KW - Animal models KW - NADPH-ferrihemoprotein reductase KW - Differentiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Differentiation+of+Prohaptens+from+Direct+Acting+Contact+Chemical+Allergens+Using+a+Cytochrome+P450+Reductase+Deficient+Mouse+Model&rft.au=Chipinda%2C+I%3BBlachere%2C+F%3BAnderson%2C+S%3BSiegel%2C+P&rft.aulast=Chipinda&rft.aufirst=I&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Acute Pulmonary Responses to Mwcnt Inhalation T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312901862; 6045493 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Wolfarth, M AU - McKinney, W AU - Chen, B AU - Castranova, V AU - Porter, D Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Inhalation KW - Lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312901862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Acute+Pulmonary+Responses+to+Mwcnt+Inhalation&rft.au=Wolfarth%2C+M%3BMcKinney%2C+W%3BChen%2C+B%3BCastranova%2C+V%3BPorter%2C+D&rft.aulast=Wolfarth&rft.aufirst=M&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pulmonary Toxicity of Biodiesel Particulate Matter T2 - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AN - 1312899376; 6046898 JF - 50th Anniversary Annual Meeting of the Society of Toxicology (SOT 2011) AU - Shvedova, A AU - Kisin, E AU - Murray, A AU - Tkach, A AU - Schwegler-Berry, D AU - Young, S AU - Kagan, V AU - Bugarski, A Y1 - 2011/03/06/ PY - 2011 DA - 2011 Mar 06 KW - Toxicity KW - Particulate matter KW - biofuels KW - Diesel KW - Lung KW - Suspended particulate matter KW - Biofuels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312899376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.atitle=Pulmonary+Toxicity+of+Biodiesel+Particulate+Matter&rft.au=Shvedova%2C+A%3BKisin%2C+E%3BMurray%2C+A%3BTkach%2C+A%3BSchwegler-Berry%2C+D%3BYoung%2C+S%3BKagan%2C+V%3BBugarski%2C+A&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2011-03-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=50th+Anniversary+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Toxicologist11.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of Pharmacology, Biology, and Disease/Gene Networks to Advance Mechanism for Clinically Observed Adverse Events T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1313025135; 6033047 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Bai, J AU - Lesko, L AU - Abernethy, D Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology KW - Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313025135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Use+of+Pharmacology%2C+Biology%2C+and+Disease%2FGene+Networks+to+Advance+Mechanism+for+Clinically+Observed+Adverse+Events&rft.au=Bai%2C+J%3BLesko%2C+L%3BAbernethy%2C+D&rft.aulast=Bai&rft.aufirst=J&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Successful Career as a Clinical Pharmacology Reviewer at FDA T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312970247; 6032892 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Reynolds, Kellie Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology KW - FDA KW - careers KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312970247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=A+Successful+Career+as+a+Clinical+Pharmacology+Reviewer+at+FDA&rft.au=Reynolds%2C+Kellie&rft.aulast=Reynolds&rft.aufirst=Kellie&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Review of Transporter-Related Post-Marketing Requirement (PMR)/Post-Marketing Commitment (PMC) Study Reports T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312950333; 6032926 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Fan, Ying Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312950333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Review+of+Transporter-Related+Post-Marketing+Requirement+%28PMR%29%2FPost-Marketing+Commitment+%28PMC%29+Study+Reports&rft.au=Fan%2C+Ying&rft.aulast=Fan&rft.aufirst=Ying&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Comparison of Cg and Mdrd Equations for Dosage Adjustment in Renal Impairment T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312949433; 6033039 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Park, E AU - Ko, C. AU - Crentsil, V AU - Zhang, J AU - Zhang, L AU - Huang, S AU - Xiao, S AU - Mehrotra, N AU - Alabi, E AU - Stockbridge, N AU - Xu, N. Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - renal function KW - Mathematical models KW - Kidneys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=A+Comparison+of+Cg+and+Mdrd+Equations+for+Dosage+Adjustment+in+Renal+Impairment&rft.au=Park%2C+E%3BKo%2C+C.%3BCrentsil%2C+V%3BZhang%2C+J%3BZhang%2C+L%3BHuang%2C+S%3BXiao%2C+S%3BMehrotra%2C+N%3BAlabi%2C+E%3BStockbridge%2C+N%3BXu%2C+N.&rft.aulast=Park&rft.aufirst=E&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Relevance and Value of in Vitro P-Gp Inhibition Data for New Molecular Entities T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312949392; 6033038 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Agarwal, S AU - Zhang, L AU - Huang, S Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Relevance+and+Value+of+in+Vitro+P-Gp+Inhibition+Data+for+New+Molecular+Entities&rft.au=Agarwal%2C+S%3BZhang%2C+L%3BHuang%2C+S&rft.aulast=Agarwal&rft.aufirst=S&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Investigation of Possible Formulation Effect on Digoxin Absorption T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312949311; 6033036 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Zhang, L AU - Agarwal, S AU - Huang, S AU - Hu, N. Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Absorption KW - digoxin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312949311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Investigation+of+Possible+Formulation+Effect+on+Digoxin+Absorption&rft.au=Zhang%2C+L%3BAgarwal%2C+S%3BHuang%2C+S%3BHu%2C+N.&rft.aulast=Zhang&rft.aufirst=L&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Clinical Pharmacology and Rare/Orphan Diseases: Maintaining Standards While Pursuing Development T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312948829; 6032898 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Bashaw, Dennis Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312948829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Clinical+Pharmacology+and+Rare%2FOrphan+Diseases%3A+Maintaining+Standards+While+Pursuing+Development&rft.au=Bashaw%2C+Dennis&rft.aulast=Bashaw&rft.aufirst=Dennis&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Are Single Nucleotide Polymorphisms of cyp2c9 a Risk Factor for Nsaid-Associated Adverse Events? T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312948469; 6033137 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Naraharisetti, S AU - Nallani, S AU - Doddapaneni, S AU - Pacanowski, M Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Side effects KW - Risk factors KW - Single-nucleotide polymorphism KW - Nucleotides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312948469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Are+Single+Nucleotide+Polymorphisms+of+cyp2c9+a+Risk+Factor+for+Nsaid-Associated+Adverse+Events%3F&rft.au=Naraharisetti%2C+S%3BNallani%2C+S%3BDoddapaneni%2C+S%3BPacanowski%2C+M&rft.aulast=Naraharisetti&rft.aufirst=S&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Estimation of Creatinine Clearance (Eclcr) across All Weight Strata T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312941847; 6033022 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Park, E AU - Zhang, J AU - Dong, T AU - Ko, C. AU - Crentsil, V AU - Stockbridge, N AU - Xu, N. AU - Pai, M Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Creatinine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312941847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Estimation+of+Creatinine+Clearance+%28Eclcr%29+across+All+Weight+Strata&rft.au=Park%2C+E%3BZhang%2C+J%3BDong%2C+T%3BKo%2C+C.%3BCrentsil%2C+V%3BStockbridge%2C+N%3BXu%2C+N.%3BPai%2C+M&rft.aulast=Park&rft.aufirst=E&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FDA Perspective - Evaluation of Drug Interactions T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312931632; 6032908 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Huang, Shiew-Mei Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - drug interaction KW - FDA KW - Drug interaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=FDA+Perspective+-+Evaluation+of+Drug+Interactions&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Dose Adjustment in Patients with Hepatic Impairment T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312931286; 6032887 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Zhang, Lei Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Liver UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Dose+Adjustment+in+Patients+with+Hepatic+Impairment&rft.au=Zhang%2C+Lei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - How FDA is Leading the Drive to Personalized Medicine T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312931014; 6032881 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Lesko, Lawrence Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=How+FDA+is+Leading+the+Drive+to+Personalized+Medicine&rft.au=Lesko%2C+Lawrence&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspectives and Experiences T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312930964; 6032880 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Uhl, Kathleen Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Pharmacology KW - Therapeutics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312930964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Regulatory+Perspectives+and+Experiences&rft.au=Uhl%2C+Kathleen&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Renal Function Change with Aging: Cross-Sectional versus Longitudinal Analysis T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312924739; 6033027 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Chung, S AU - Hand, A AU - Vaidyanathan, J AU - Choe, S AU - Sahajwalla, C Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - aging KW - renal function KW - Aging KW - Renal function UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312924739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Renal+Function+Change+with+Aging%3A+Cross-Sectional+versus+Longitudinal+Analysis&rft.au=Chung%2C+S%3BHand%2C+A%3BVaidyanathan%2C+J%3BChoe%2C+S%3BSahajwalla%2C+C&rft.aulast=Chung&rft.aufirst=S&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Medicine for Children: Regulatory Initiatives for Better Development and Faster Approval T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312924038; 6032946 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Rahman, Atiqur Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312924038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Medicine+for+Children%3A+Regulatory+Initiatives+for+Better+Development+and+Faster+Approval&rft.au=Rahman%2C+Atiqur&rft.aulast=Rahman&rft.aufirst=Atiqur&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quantifying Renal Effects on Drug Exposure and Response: A Regulatory Perspective T2 - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AN - 1312923202; 6032859 JF - 112th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2011) AU - Gobburu, Jogarao Y1 - 2011/03/02/ PY - 2011 DA - 2011 Mar 02 KW - Drugs KW - Kidneys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.atitle=Quantifying+Renal+Effects+on+Drug+Exposure+and+Response%3A+A+Regulatory+Perspective&rft.au=Gobburu%2C+Jogarao&rft.aulast=Gobburu&rft.aufirst=Jogarao&rft.date=2011-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=112th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2011%20Annual%20Meeting/2011AM%20Reg%20Broc_Digilink%20WEB%20FINAL2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Human posture simulation to assess cumulative spinal load due to manual lifting. Part I: methods AN - 954631002; 14337407 AB - The estimation of cumulative spinal load (CSL) resulting from exposure to manual materials handling (MMH) may provide a sensitive method for assessing the risk of highly varying exposures. This article reports on a CSL method that involves human posture simulation of workers from videotape in order to assess spinal load exposures due to MMH. The proposed method appears to be sensitive to different durations of exposure, easy to use and useful for assessing jobs with a high degree of variability in task characteristics between lifts. Although the method remains to be validated, it appears to be a useful addition to the range of tools available for assessing manual lifting exposures in worksite-based epidemiologic studies. Ergonomic methods are lacking for assessing highly variable MMH tasks, such as tasks found in warehousing. The existing methods do not include sufficient factors to account for variable exposure patterns or tasks with highly variable task characteristics, such as varying load weights and lift geometries. The CSL assessment method described in this article may provide a way to evaluate these types of tasks in order to assess the overall risk of workers developing work-related musculoskeletal disorders. JF - Theoretical Issues in Ergonomics Science AU - Waters, Thomas R AU - Lu, Ming-Lun AU - Werren, Dwight AU - Piacitelli, Laurie AD - National Institute for Occupational Safety and Health, Taft Laboratories, Cincinnati, OH 45226, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 176 EP - 188 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 12 IS - 2 SN - 1464-536X, 1464-536X KW - Health & Safety Science Abstracts KW - Materials handling KW - Simulation KW - musculoskeletal system KW - lifting KW - Ergonomics KW - Occupational exposure KW - posture KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954631002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Theoretical+Issues+in+Ergonomics+Science&rft.atitle=Human+posture+simulation+to+assess+cumulative+spinal+load+due+to+manual+lifting.+Part+I%3A+methods&rft.au=Waters%2C+Thomas+R%3BLu%2C+Ming-Lun%3BWerren%2C+Dwight%3BPiacitelli%2C+Laurie&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2011-03-01&rft.volume=12&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Theoretical+Issues+in+Ergonomics+Science&rft.issn=1464536X&rft_id=info:doi/10.1080%2F14639221003639921 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Materials handling; Simulation; lifting; musculoskeletal system; Occupational exposure; Ergonomics; Occupational health; posture DO - http://dx.doi.org/10.1080/14639221003639921 ER - TY - JOUR T1 - Bayesian non-parametric multivariate statistical models for testing association between quantitative traits and candidate genes in structured populations AN - 940979363; 4280454 AB - Population-based linkage disequilibrium mapping permits finer scale mapping than linkage analysis. However, the population-based association mapping is subject to false positive results due to the population structure and the kinship between the samples. Although there is interest in simultaneously testing the association between a candidate gene and the multiple phenotypes of interest, the currently available association mapping methods are limited to univariate traits only. Here we present a new method for population-based multitrait candidate gene association mapping as a Bayesian semiparametric approach, where the error distribution is flexibly modelled via a multivariate mixture of Polya trees centred on the family of multivariate normal distributions. The method that we develop accounts for the population structure and the complex relatedness between the samples. We compare the new proposal in type I error rate and power with the existing multivariate version of the parametric model of Yu and co-workers and Li's univariate semiparametric model by using the previously published two type Arabidopsis thaliana flowering data sets of association mapping, as well as simulated data. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Hanson, Timothy AU - Li, Meijuan AD - US Food and Drug Administration Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 207 EP - 219 VL - 60 IS - 2 SN - 0035-9254, 0035-9254 KW - Economics KW - Comparative analysis KW - Genetics KW - Genes KW - Multivariate analysis KW - Statistical models KW - Mapping KW - Models KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/940979363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Bayesian+non-parametric+multivariate+statistical+models+for+testing+association+between+quantitative+traits+and+candidate+genes+in+structured+populations&rft.au=Hanson%2C+Timothy%3BLi%2C+Meijuan&rft.aulast=Hanson&rft.aufirst=Timothy&rft.date=2011-03-01&rft.volume=60&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Fj.1467-9876.2010.00741.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1512 3865 4025; 8379 12224 971; 12230 8163; 5455 1678; 5460 1615 8573 11325; 7675 3681; 2630 971; 8163 DO - http://dx.doi.org/10.1111/j.1467-9876.2010.00741.x ER - TY - JOUR T1 - Angiotensin II AT sub(1) Receptor Blockade Ameliorates Brain Inflammation AN - 907158087; 14378273 AB - Brain inflammation has a critical role in the pathophysiology of brain diseases of high prevalence and economic impact, such as major depression, schizophrenia, post-traumatic stress disorder, Parkinson's and Alzheimer's disease, and traumatic brain injury. Our results demonstrate that systemic administration of the centrally acting angiotensin II AT sub(1) receptor blocker (ARB) candesartan to normotensive rats decreases the acute brain inflammatory response to administration of the bacterial endotoxin lipopolysaccharide (LPS), a model of brain inflammation. The broad anti-inflammatory effects of candesartan were seen across the entire inflammatory cascade, including decreased production and release to the circulation of centrally acting proinflammatory cytokines, repression of nuclear transcription factors activation in the brain, reduction of gene expression of brain proinflammatory cytokines, cytokine and prostanoid receptors, adhesion molecules, proinflammatory inducible enzymes, and reduced microglia activation. These effects are widespread, occurring not only in well-known brain target areas for circulating proinflammatory factors and LPS, that is, hypothalamic paraventricular nucleus and the subfornical organ, but also in the prefrontal cortex, hippocampus, and amygdala. Candesartan reduced the associated anorexic effects, and ameliorated associated body weight loss and anxiety. Direct anti-inflammatory effects of candesartan were also documented in cultured rat microglia, cerebellar granule cells, and cerebral microvascular endothelial cells. ARBs are widely used in the treatment of hypertension and stroke, and their anti-inflammatory effects contribute to reduce renal and cardiac failure. Our results indicate that these compounds may offer a novel and safe therapeutic approach for the treatment of brain disorders. JF - Neuropsychopharmacology AU - Benicky, Julius AU - Sanchez-Lemus, Enrique AU - Honda, Masaru AU - Pang, Tao AU - Orecna, Martina AU - Wang, Juan AU - Leng, Yan AU - Chuang, De-Maw AU - Saavedra, Juan M AD - Section on Pharmacology, Division of Intramural Research Programs, Department of Health and Human Services, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 857 EP - 870 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 36 IS - 4 SN - 0893-133X, 0893-133X KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Anxiety KW - Parkinson's disease KW - Alzheimer's disease KW - Cerebellum KW - Paraventricular nucleus KW - Gene expression KW - Endothelial cells KW - Schizophrenia KW - Mental disorders KW - Lipopolysaccharides KW - Cytokines KW - Traumatic brain injury KW - Heart KW - Depression KW - Stroke KW - Enzymes KW - Renal failure KW - prostaglandin receptors KW - Microglia KW - Angiotensin II KW - Post-traumatic stress disorder KW - Inflammation KW - Body weight loss KW - Neurodegenerative diseases KW - Subfornical organ KW - Movement disorders KW - Transcription factors KW - Kidney KW - Amygdala KW - Cortex (prefrontal) KW - J 02350:Immunology KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907158087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Angiotensin+II+AT+sub%281%29+Receptor+Blockade+Ameliorates+Brain+Inflammation&rft.au=Benicky%2C+Julius%3BSanchez-Lemus%2C+Enrique%3BHonda%2C+Masaru%3BPang%2C+Tao%3BOrecna%2C+Martina%3BWang%2C+Juan%3BLeng%2C+Yan%3BChuang%2C+De-Maw%3BSaavedra%2C+Juan+M&rft.aulast=Benicky&rft.aufirst=Julius&rft.date=2011-03-01&rft.volume=36&rft.issue=4&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2010.225 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Anxiety; Parkinson's disease; Alzheimer's disease; Cerebellum; Paraventricular nucleus; Schizophrenia; Endothelial cells; Gene expression; Mental disorders; Cytokines; Lipopolysaccharides; Traumatic brain injury; Heart; Depression; Stroke; Renal failure; Enzymes; prostaglandin receptors; Angiotensin II; Microglia; Post-traumatic stress disorder; Inflammation; Body weight loss; Neurodegenerative diseases; Subfornical organ; Movement disorders; Transcription factors; Kidney; Amygdala; Cortex (prefrontal) DO - http://dx.doi.org/10.1038/npp.2010.225 ER - TY - JOUR T1 - Comparison of Three Selective Media and Validation of the VIDAS Campylobacter Assay for the Detection of Campylobacter jejuni in Ground Beef and Fresh-Cut Vegetables AN - 907157471; 14407268 AB - In this study, three different selective media, modified cefoperazone charcoal deoxycholate agar (mCCDA), Karmali agar, and Preston agar, were compared for isolating Campylobacter jejuni from artificially contaminated ground beef and fresh-cut vegetables that have different levels of background microflora. Concurrently, an automated enzyme-linked immunosorbent assay method for detecting Campylobacter spp. (VIDAS Campylobacter) was evaluated by comparing it with the culture methods. Food samples inoculated with C. jejuni were enriched in Bolton broth at 42 degree C for 44 h and then streaked onto the three different selective media, followed by incubation under microaerobic conditions at 42 degree C for 48 h. The enriched Bolton broth (1 ml) was used in the VIDAS Campylobacter assay. No statistical differences in sensitivities were observed between the three selective media for ground beef and fresh-cut vegetables, but the selectivity of Preston agar was better (P 0.05) to those of all of the medium combinations in ground beef. However, more positive samples (P < 0.05) were detected with the VIDAS Campylobacter than with the selective agars, except for the combinations of mCCDA plus Preston agar or mCCDA plus Karmali agar plus Preston agar in fresh-cut vegetables. JF - Journal of Food Protection AU - Chon, Jung-Whan AU - Hyeon, Ji-Yeon AU - Choi, In-Soo AU - Park, Chan-Kyu AU - Kim, Soo-Ki AU - Heo, Seok AU - Oh, Se-Wook AU - Song, Kwang-Young AU - Seo, Kun-Ho AD - Department of Public Health and 2 Department of Infectious Diseases, College of Veterinary Medicine, and 3 Department of Animal Biotechnology and 43-701, Korea; 5Research Planning & Management Division, Korea Food and Drug Administration, 5 Nokbeon-dong, Eunpyeong-gu, 122-704, Korea; and 6 Department of Food and Nutrition, Kookmin University, Jeong-Neung Dong, Seong-Buk Gu, Seoul 136-702, KoreaMS 10-302: Received 26 July 2010/Accepted 24 November 2010* Author for correspondence. Tel: + 82 2 450 4121; Fax: + 82 2 450 3037; E-mail: bracstu3[AT]konkuk.ac.kr. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 456 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 74 IS - 3 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology KW - Charcoal KW - Agar KW - Vegetables KW - Enzyme-linked immunosorbent assay KW - Statistics KW - Cefoperazone KW - Beef KW - Campylobacter jejuni KW - Food KW - Microflora KW - Media (selective) KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Comparison+of+Three+Selective+Media+and+Validation+of+the+VIDAS+Campylobacter+Assay+for+the+Detection+of+Campylobacter+jejuni+in+Ground+Beef+and+Fresh-Cut+Vegetables&rft.au=Chon%2C+Jung-Whan%3BHyeon%2C+Ji-Yeon%3BChoi%2C+In-Soo%3BPark%2C+Chan-Kyu%3BKim%2C+Soo-Ki%3BHeo%2C+Seok%3BOh%2C+Se-Wook%3BSong%2C+Kwang-Young%3BSeo%2C+Kun-Ho&rft.aulast=Chon&rft.aufirst=Jung-Whan&rft.date=2011-03-01&rft.volume=74&rft.issue=3&rft.spage=456&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Charcoal; Agar; Enzyme-linked immunosorbent assay; Vegetables; Statistics; Cefoperazone; Beef; Food; Microflora; Media (selective); Campylobacter jejuni ER - TY - JOUR T1 - Estimated daily intake of phthalates in occupationally exposed groups AN - 907153041; 14381105 AB - Improved analytical methods for measuring urinary phthalate metabolites have resulted in biomarker-based estimates of phthalate daily intake for the general population, but not for occupationally exposed groups. In 2003-2005, we recruited 156 workers from eight industries where materials containing diethyl phthalate (DEP), dibutyl phthalate (DBP), and/or di(2-ethylhexyl) phthalate (DEHP) were used as part of the worker's regular job duties. Phthalate metabolite concentrations measured in the workers' end-shift urine samples were used in a simple pharmacokinetic model to estimate phthalate daily intake. DEHP intake estimates based on three DEHP metabolites combined were 0.6-850 mu g/kg/day, with the two highest geometric mean (GM) intakes in polyvinyl chloride (PVC) film manufacturing (17 mu g/kg/day) and PVC compounding (12 mu g/kg/day). All industries, except phthalate manufacturing, had some workers whose DEHP exposure exceeded the U.S. reference dose (RfD) of 20 mu g/kg/day. A few workers also exceeded the DEHP European tolerable daily intake (TDI) of 50 mu g/kg/day. DEP intake estimates were 0.5-170 mu g/kg/day, with the highest GM in phthalate manufacturing (27 mu g/kg/day). DBP intake estimates were 0.1-76 mu g/kg/day, with the highest GMs in rubber gasket and in phthalate manufacturing (17 mu g/kg/day, each). No DEP or DBP intake estimates exceeded their respective RfDs. The DBP TDI (10 mu g/kg/day) was exceeded in three rubber industries and in phthalate manufacturing. These intake estimates are subject to several uncertainties; however, an occupational contribution to phthalate daily intake is clearly indicated in some industries. JF - Journal of Exposure Science and Environmental Epidemiology AU - Hines, Cynthia J AU - Hopf, Nancy B N AU - Deddens, James A AU - Silva, Manori J AU - Calafat, Antonia M AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 133 EP - 141 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 21 IS - 2 SN - 1559-0631, 1559-0631 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Bioindicators KW - Chlorides KW - Metabolites KW - Models KW - Occupational exposure KW - Pharmacokinetics KW - Phthalic acid KW - Rubber KW - Urine KW - Workers KW - diethyl phthalate KW - phthalates KW - polyvinyl chloride KW - USA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907153041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Estimated+daily+intake+of+phthalates+in+occupationally+exposed+groups&rft.au=Hines%2C+Cynthia+J%3BHopf%2C+Nancy+B+N%3BDeddens%2C+James+A%3BSilva%2C+Manori+J%3BCalafat%2C+Antonia+M&rft.aulast=Hines&rft.aufirst=Cynthia&rft.date=2011-03-01&rft.volume=21&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2009.62 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Workers; Urine; polyvinyl chloride; Rubber; diethyl phthalate; Metabolites; Pharmacokinetics; Occupational exposure; Models; Phthalic acid; Bioindicators; phthalates; Chlorides; USA DO - http://dx.doi.org/10.1038/jes.2009.62 ER - TY - JOUR T1 - Biotransformation of quinazoline and phthalazine by Aspergillus niger AN - 907152094; 14440171 AB - Cultures of Aspergillus niger NRRL-599 in fluid Sabouraud medium were grown with quinazoline and phthalazine for 7 days. Metabolites were purified by high-performance liquid chromatography and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Quinazoline was oxidized to 4-quinazolinone and 2,4-quinazolinedione, and phthalazine was oxidized to 1-phthalazinone. JF - Journal of Bioscience and Bioengineering AU - Sutherland, John B AU - Heinze, Thomas M AU - Schnackenberg, Laura K AU - Freeman, James P AU - Williams, Anna J AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, john.sutherland@fda.hhs.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 333 EP - 335 PB - The Society for Biotechnology, Japan VL - 111 IS - 3 SN - 1389-1723, 1389-1723 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - biotransformation KW - N.M.R. KW - Metabolites KW - Spectroscopy KW - Aspergillus niger KW - Mass spectroscopy KW - W 30910:Imaging KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907152094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bioscience+and+Bioengineering&rft.atitle=Biotransformation+of+quinazoline+and+phthalazine+by+Aspergillus+niger&rft.au=Sutherland%2C+John+B%3BHeinze%2C+Thomas+M%3BSchnackenberg%2C+Laura+K%3BFreeman%2C+James+P%3BWilliams%2C+Anna+J&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2011-03-01&rft.volume=111&rft.issue=3&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bioscience+and+Bioengineering&rft.issn=13891723&rft_id=info:doi/10.1016%2Fj.jbiosc.2010.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; biotransformation; Metabolites; N.M.R.; Spectroscopy; Mass spectroscopy; Aspergillus niger DO - http://dx.doi.org/10.1016/j.jbiosc.2010.11.017 ER - TY - JOUR T1 - Wood Dust Sampling: Field Evaluation of Personal Samplers When Large Particles Are Present AN - 904469405; 14371665 AB - Recent recommendations for wood dust sampling include sampling according to the inhalable convention of International Organization for Standardization (ISO) 7708 (1995) Air quality-particle size fraction definitions for health-related sampling. However, a specific sampling device is not mandated, and while several samplers have laboratory performance approaching theoretical for an 'inhalable' sampler, the best choice of sampler for wood dust is not clear. A side-by-side field study was considered the most practical test of samplers as laboratory performance tests consider overall performance based on a wider range of particle sizes than are commonly encountered in the wood products industry. Seven companies in the wood products industry of the Southeast USA (MS, KY, AL, and WV) participated in this study. The products included hardwood flooring, engineered hardwood flooring, door skins, shutter blinds, kitchen cabinets, plywood, and veneer. The samplers selected were 37-mm closed-face cassette with ACCU-CAPTM, Button, CIP10-I, GSP, and Institute of Occupational Medicine. Approximately 30 of each possible pairwise combination of samplers were collected as personal sample sets. Paired samplers of the same type were used to calculate environmental variance that was then used to determine the number of pairs of samples necessary to detect any difference at a specified level of confidence. Total valid sample number was 888 (444 valid pairs). The mass concentration of wood dust ranged from 0.02 to 195 mg m-3. Geometric mean (geometric standard deviation) and arithmetic mean (standard deviation) of wood dust were 0.98 mg m-3 (3.06) and 2.12 mg m-3 (7.74), respectively. One percent of the samples exceeded 15 mg m-3, 6% exceeded 5 mg m-3, and 48% exceeded 1 mg m-3. The number of collected pairs is generally appropriate to detect a 35% difference when outliers (negative mass loadings) are removed. Statistical evaluation of the nonsimilar sampler pair results produced a finding of no significant difference between any pairing of sampler type. A practical consideration for sampling in the USA is that the ACCU-CAPTM is similar to the sampler currently used by the Occupational Safety and Health Administration for purposes of demonstrating compliance with its permissible exposure limit for wood dust, which is the same as for Particles Not Otherwise Regulated, also known as inert dust or nuisance dust (Method PV2121). JF - Annals of Occupational Hygiene AU - Lee, Taekhee AU - Harper, Martin AU - Slaven, James E AU - Lee, Kiyoung AU - Rando, Roy J AU - Maples, Elizabeth H AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 180 EP - 191 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 55 IS - 2 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Inhalation KW - Skin KW - hardwoods KW - Compliance KW - Occupational safety KW - Wood KW - Particulates KW - USA, Southeast KW - Dust KW - USA KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904469405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Wood+Dust+Sampling%3A+Field+Evaluation+of+Personal+Samplers+When+Large+Particles+Are+Present&rft.au=Lee%2C+Taekhee%3BHarper%2C+Martin%3BSlaven%2C+James+E%3BLee%2C+Kiyoung%3BRando%2C+Roy+J%3BMaples%2C+Elizabeth+H&rft.aulast=Lee&rft.aufirst=Taekhee&rft.date=2011-03-01&rft.volume=55&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inhalation; Skin; Occupational safety; Compliance; hardwoods; Wood; Particulates; Dust; Occupational health; USA; USA, Southeast ER - TY - JOUR T1 - XPC is essential for nucleotide excision repair of zidovudine-induced DNA damage in human hepatoma cells AN - 902361335; 14512942 AB - Zidovudine (3a super(2)-azido-3a super(2)-dexoythymidine, AZT), a nucleoside reverse transcriptase inhibitor, can be incorporated into DNA and cause DNA damage. The mechanisms underlying the repair of AZT-induced DNA damage are unknown. To investigate the pathways involved in the recognition and repair of AZT-induced DNA damage, human hepatoma HepG2 cells were incubated with AZT for 2weeks and the expression of DNA damage signaling pathways was determined using a pathway-based real-time PCR array. Compared to control cultures, damaged DNA binding and nucleotide excision repair (NER) pathways showed significantly increased gene expression. Further analysis indicated that AZT treatment increased the expression of genes associated with NER, including XPC, XPA, RPA1, GTF2H1, and ERCC1. Western blot analysis demonstrated that the protein levels of XPC and GTF2H1 were also significantly up-regulated. To explore further the function of XPC in the repair of AZT-induced DNA damage, XPC expression was stably knocked down by 71% using short hairpin RNA interference. In the XPC knocked-down cells, 100I14M AZT treatment significantly increased [ 3 H]AZT incorporation into DNA, decreased the total number of viable cells, increased the release of lactate dehydrogenase, induced apoptosis, and caused a more extensive G2/M cell cycle arrest when compared to non-transfected HepG2 cells or HepG2 cells transfected with a scrambled short hairpin RNA sequence. Overall, these data indicate that XPC plays an essential role in the NER repair of AZT-induced DNA damage. JF - Toxicology and Applied Pharmacology AU - Wu, Qiangen AU - Beland, Frederick A AU - Chang, Ching-Wei AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA, jia-long.fang@fda.hhs.gov Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 155 EP - 162 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 251 IS - 2 SN - 0041-008X, 0041-008X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Western blotting KW - XPC protein KW - Data processing KW - Apoptosis KW - Nucleotide sequence KW - Zidovudine KW - Cell culture KW - L-Lactate dehydrogenase KW - Gene expression KW - Hepatoma KW - DNA damage KW - ERCC1 protein KW - Nucleotide excision repair KW - RNA-mediated interference KW - Polymerase chain reaction KW - Signal transduction KW - nucleoside reverse transcriptase inhibitors KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902361335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=XPC+is+essential+for+nucleotide+excision+repair+of+zidovudine-induced+DNA+damage+in+human+hepatoma+cells&rft.au=Wu%2C+Qiangen%3BBeland%2C+Frederick+A%3BChang%2C+Ching-Wei%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Qiangen&rft.date=2011-03-01&rft.volume=251&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Western blotting; XPC protein; Apoptosis; Data processing; Nucleotide sequence; Zidovudine; Cell culture; L-Lactate dehydrogenase; Gene expression; DNA damage; Hepatoma; ERCC1 protein; Nucleotide excision repair; Polymerase chain reaction; RNA-mediated interference; nucleoside reverse transcriptase inhibitors; Signal transduction DO - http://dx.doi.org/10.1016/j.taap.2010.12.009 ER - TY - JOUR T1 - The Benefits Of Health Information Technology: A Review Of The Recent Literature Shows Predominantly Positive Results AN - 887493464; 201115448 AB - An unprecedented federal effort is under way to boost the adoption of electronic health records and spur innovation in health care deliver We reviewed the recent literature on health information technology to determine its effect on outcomes, including quality, efficiency, and provider satisfaction. We found that 92 percent of the recent articles on health information technology reached conclusions that were positive overall. We also found that the benefits of the technology are beginning to emerge in smaller practices and organizations, as well as in large organizations that were early adopters. However, dissatisfaction with electronic health records among some providers remains a problem and a barrier to achieving the potential of health information technology. These realities highlight the need for studies that document the challenging aspects of implementing health information technology more specifically and how these challenges might be addressed. Adapted from the source document. JF - Health Affairs AU - Beeuwkes Buntin, Melinda AU - Burke, Matthew F AU - Hoaglin, Michael C AU - Blumenthal, David AD - Department of Health and Human Services, Washington, D.C Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 464 EP - 471 PB - Project HOPE, Bethesda MD VL - 30 IS - 3 SN - 0278-2715, 0278-2715 KW - Quality of care KW - Health care KW - Computerized medical records KW - Innovation KW - Information technology KW - Health information KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/887493464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=The+Benefits+Of+Health+Information+Technology%3A+A+Review+Of+The+Recent+Literature+Shows+Predominantly+Positive+Results&rft.au=Beeuwkes+Buntin%2C+Melinda%3BBurke%2C+Matthew+F%3BHoaglin%2C+Michael+C%3BBlumenthal%2C+David&rft.aulast=Beeuwkes+Buntin&rft.aufirst=Melinda&rft.date=2011-03-01&rft.volume=30&rft.issue=3&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0178 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-09-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Information technology; Health information; Computerized medical records; Innovation; Quality of care; Health care DO - http://dx.doi.org/10.1377/hlthaff.2011.0178 ER - TY - JOUR T1 - FDA Tobacco Product Regulations: A Powerful Tool for Tobacco Control AN - 881466065; 2011-104544 AB - The 2009 passage of the Family Smoking Prevention and Tobacco Control Act launched the most far-reaching public health intervention in a generation. For the first time ever, the U.S. Food and Drug Administration (FDA) is fully authorized to use its regulatory authority to combat the nation's leading cause of preventable death: tobacco. However, FDA regulation is not only a powerful new tool to reduce tobacco-related disease and death, it also poses new opportunities and challenges to public health practitioners at every level of government, academia, research, and advocacy. Adapted from the source document. JF - Public Health Reports AU - Deyton, Lawrence R AD - Center for Tobacco Products, U.S. Food and Drug Administration, 9200 Corporate Blvd., Rockville, MD 20850-3229, Tel. 877-287-1373 E-mail: ctpexecsec@fda.hhs.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 167 EP - 169 PB - Oxford University Press, UK VL - 126 IS - 2 SN - 0033-3549, 0033-3549 KW - Agriculture and agricultural policy - Crop management and agricultural production KW - Health conditions and policy - Health and health policy KW - Economic conditions and policy - Economic policy, planning, and development KW - Law and ethics - Law and jurisprudence KW - Business and service sector - Business management KW - Social conditions and policy - Drinking, smoking, and drug addiction KW - Health conditions and policy - Diseases and disorders KW - Tobacco industry KW - Smoking KW - United States Food and drug administration KW - Advocacy KW - Authority KW - Diseases KW - Regulation KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881466065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=FDA+Tobacco+Product+Regulations%3A+A+Powerful+Tool+for+Tobacco+Control&rft.au=Deyton%2C+Lawrence+R&rft.aulast=Deyton&rft.aufirst=Lawrence&rft.date=2011-03-01&rft.volume=126&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2011-08-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United States Food and drug administration; Public health; Regulation; Tobacco industry; Advocacy; Authority; Smoking; Diseases ER - TY - JOUR T1 - Using Mass Media and the Internet As Tools to Diagnose Hepatitis C Infections in the General Population AN - 872127343; 14444121 AB - Many individuals with hepatitis C virus (HCV) infection are undiagnosed This study describes the development and the use and outcomes of a mass media campaign, combined with an Internet risk assessment and an Internet-mediated blood-testing procedure for HCV to identify individuals infected with HCV in the general population. Methods: From April 2007 to December 2008, individuals in HCV risk groups were referred to an online, previously validated risk-assessment questionnaire at www.heptest.nl. Individuals at risk could download a referral letter for a free, anonymous HCV blood test in a nonclinical setting. Test results could be obtained online, 1 week later, using a personal log-in code. Anti-HCV-positive participants were requested to visit the Public Health Service for confirmation andA testing. Chronically HCV-infected individuals were referred for treatment. Data were analyzed in 2009-2010. Results: The website attracted 40,902 visitors. Of the 9653 who completed the questionnaire, 2553 were at risk for HCV (26.4%). Main reported risk factors were a blood transfusion prior to 1992 and noninjecting drug use. Of the 1480 eligible for the blood test, 420 opted for testing (28%). HCV antibodies were detected in 3.6% (n=15, 95% CI=2.1%, 5.7%); of the 12 with a chronic HCV infection, six began treatment. Conclusions: Internet-mediated risk-based testing for HCV has proved to be a feasible and effective strategy to identify undiagnosed HCV infection in the general population. All HCV-infected individuals belonged to hard-to-reach populations. Test uptake was 28%, which is high for an online project that includes blood testing. Because Internet-mediated testing is low-cost, this strategy holds promise for future screening. JF - American Journal of Preventive Medicine AU - Zuure, Freke R AU - Davidovich, Udi AU - Coutinho, Roel A AU - Kok, Gerjo AU - Hoebe, Christian JPA AU - Van den Hoek, Anneke AU - Jansen, Peter LM AU - Van Leeuwen-Gilbert, Paula AU - Verheuvel, Nicole C AU - Weegink, Christine J AU - Prins, Maria AD - Cluster Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands, fzuure@ggd.amsterdam.nl fzuure@ggd.amsterdam.nl Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 345 EP - 352 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 40 IS - 3 SN - 0749-3797, 0749-3797 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Risk assessment KW - mass media KW - transfusion KW - Drug abuse KW - Public health KW - Risk factors KW - infection KW - Risk groups KW - Hepatitis C KW - Drugs KW - Inventories KW - Data processing KW - Hepatitis KW - Antibodies KW - Blood transfusion KW - Hepatitis C virus KW - Chronic infection KW - Internet KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872127343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Using+Mass+Media+and+the+Internet+As+Tools+to+Diagnose+Hepatitis+C+Infections+in+the+General+Population&rft.au=Zuure%2C+Freke+R%3BDavidovich%2C+Udi%3BCoutinho%2C+Roel+A%3BKok%2C+Gerjo%3BHoebe%2C+Christian+JPA%3BVan+den+Hoek%2C+Anneke%3BJansen%2C+Peter+LM%3BVan+Leeuwen-Gilbert%2C+Paula%3BVerheuvel%2C+Nicole+C%3BWeegink%2C+Christine+J%3BPrins%2C+Maria&rft.aulast=Zuure&rft.aufirst=Freke&rft.date=2011-03-01&rft.volume=40&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inventories; Antibodies; Blood transfusion; Data processing; Risk factors; Chronic infection; Risk groups; Hepatitis C; Drugs; Internet; Public health; Hepatitis; mass media; infection; transfusion; Drug abuse; Hepatitis C virus DO - http://dx.doi.org/10.1016/j.amepre.2010.11.019 ER - TY - JOUR T1 - Absence of detectable xenotropic murine leukemia virus-related virus in plasma or peripheral blood mononuclear cells of human immunodeficiency virus Type 1-infected blood donors or individuals in Africa AN - 869571433; 14521747 AB - BACKGROUND: Since the identification of xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer patients in 2006 and in chronic fatigue syndrome patients in 2009, conflicting findings have been reported regarding its etiologic role in human diseases and prevalence in general populations. In this study, we screened both plasma and peripheral blood mononuclear cells (PBMNCs) collected in Africa from blood donors and human immunodeficiency virus Type 1 (HIV-1)-infected individuals to gain evidence of XMRV infection in this geographic region. STUDY DESIGN AND METHODS: A total of 199 plasma samples, 19 PBMNC samples, and 50 culture supernatants from PBMNCs of blood donors from Cameroon found to be infected with HIV-1 and HIV-1 patients from Uganda were screened for XMRV infection using a sensitive nested polymerase chain reaction (PCR) or reverse transcription (RT)-PCR assay. RESULTS: Using highly sensitive nested PCR or RT-PCR and real-time PCR assays capable of detecting at least 10 copies of XMRV plasmid DNA per reaction, none of the 268 samples tested were found to be XMRV DNA or RNA positive. CONCLUSIONS: Our results failed to demonstrate the presence of XMRV infection in African blood donors or individuals infected with HIV-1. More studies are needed to understand the prevalence, epidemiology, and geographic distribution of XMRV infection worldwide. JF - Transfusion AU - Tang, Shixing AU - Zhao, Jiangqin AU - Viswanath, Ragupathy AU - Nyambi, Phillipe N AU - Redd, Andrew D AU - Dastyar, Armeta AU - Spacek, Lisa A AU - Quinn, Thomas C AU - Wang, Xue AU - Wood, Owen AU - Gaddam, Durga AU - Devadas, Krishnakumar AU - Hewlett, Indira K AD - From the Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland; the Department of Pathology, New York University School of Medicine, New York, New York; and the Division of Intramural Research, NIAID, NIH, Johns Hopkins University School of Medicine, Baltimore, Maryland. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 463 EP - 468 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 3 SN - 0041-1132, 0041-1132 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Blood donors KW - Cell culture KW - Epidemiology KW - Geographical distribution KW - Leukemia KW - Peripheral blood mononuclear cells KW - Plasmids KW - Polymerase chain reaction KW - Prostate cancer KW - RNA KW - Reverse transcription KW - Xenotropic KW - blood donors KW - chronic fatigue syndrome KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Africa KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869571433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Absence+of+detectable+xenotropic+murine+leukemia+virus-related+virus+in+plasma+or+peripheral+blood+mononuclear+cells+of+human+immunodeficiency+virus+Type+1-infected+blood+donors+or+individuals+in+Africa&rft.au=Tang%2C+Shixing%3BZhao%2C+Jiangqin%3BViswanath%2C+Ragupathy%3BNyambi%2C+Phillipe+N%3BRedd%2C+Andrew+D%3BDastyar%2C+Armeta%3BSpacek%2C+Lisa+A%3BQuinn%2C+Thomas+C%3BWang%2C+Xue%3BWood%2C+Owen%3BGaddam%2C+Durga%3BDevadas%2C+Krishnakumar%3BHewlett%2C+Indira+K&rft.aulast=Tang&rft.aufirst=Shixing&rft.date=2011-03-01&rft.volume=51&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02932.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Blood donors; Geographical distribution; Peripheral blood mononuclear cells; Prostate cancer; RNA; Epidemiology; Polymerase chain reaction; Cell culture; chronic fatigue syndrome; Plasmids; Xenotropic; Reverse transcription; Leukemia; blood donors; Human immunodeficiency virus; Human immunodeficiency virus 1; Africa DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02932.x ER - TY - JOUR T1 - Recent Changes in the Trends of Teen Birth Rates, 1981-2006 AN - 868221167; 201112049 AB - Purpose: To explore trends in teen birth rates by selected demographics. Methods: We used birth certificate data and joinpoint regression to examine trends in teen birth rates by age (10 -- 14, 15 -- 17, and 18 -- 19 years) and race during 1981 -- 2006 and by age and Hispanic origin during 1990 -- 2006. Joinpoint analysis describes changing trends over successive segments of time and uses annual percentage change (APC) to express the amount of increase or decrease within each segment. Results: For teens younger than 18 years, the decline in birth rates began in 1994 and ended in 2003 (APC: -- 8.03% per year for ages 10 -- 14 years; APC: -- 5.63% per year for ages 15 -- 17 years). The downward trend for 18-and 19-year-old teens began earlier (1991) and ended 1 year later (2004) (APC: -- 2.37% per year). For each study population, the trend was approximately level during the most recent time segment, except for continuing declines for 18-and 19-year-old white and Asian/Pacific Islander teens. The only increasing trend in the most recent time segment was for 18-and 19-year-old Hispanic teens. During these declines, the age distribution of teens who gave birth shifted to slightly older ages, and the percentage whose current birth was at least their second birth decreased. Conclusions: Teen birth rates were generally level during 2003/2004 -- 2006 after the long-term declines. Rates increased among older Hispanic teens. These results indicate a need for renewed attention to effective teen pregnancy prevention programs in specific populations. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Wingo, Phyllis A AU - Smith, Ruben A AU - Tevendale, Heather D AU - Ferre, Cynthia AD - Division of Reproductive Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341 E-mail: heathertevendale@cdc.hhs.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 281 EP - 288 PB - Elsevier, New York NY VL - 48 IS - 3 SN - 1054-139X, 1054-139X KW - Teen pregnancy, Family planning, Birth certificates KW - Birth rate KW - Childbirth KW - Pacific Islander people KW - Hispanic people KW - Pregnant adolescent girls KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/868221167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Recent+Changes+in+the+Trends+of+Teen+Birth+Rates%2C+1981-2006&rft.au=Wingo%2C+Phyllis+A%3BSmith%2C+Ruben+A%3BTevendale%2C+Heather+D%3BFerre%2C+Cynthia&rft.aulast=Wingo&rft.aufirst=Phyllis&rft.date=2011-03-01&rft.volume=48&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.07.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-05-18 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Adolescents; Birth rate; Hispanic people; Childbirth; Pacific Islander people; Pregnant adolescent girls DO - http://dx.doi.org/10.1016/j.jadohealth.2010.07.007 ER - TY - JOUR T1 - Ketamine anesthesia during the first week of life can cause long-lasting cognitive deficits in rhesus monkeys AN - 867747602; 14630119 AB - Previously our laboratory has shown that ketamine exposure (24h of clinically relevant anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys. Sensitivity to this ketamine-induced neurotoxicity was observed on gestational days 120a123 (in utero exposure via maternal anesthesia) and on postnatal days (PNDs) 5a6, but not on PNDs 35a37. In the present study, six monkeys were exposed on PND 5 or 6 to intravenous ketamine anesthesia to maintain a light surgical plane for 24h and six control animals were unexposed. At 7months of age all animals were weaned and began training to perform a series of cognitive function tasks as part of the National Center for Toxicological Research (NCTR) Operant Test Battery (OTB). The OTB tasks used here included those for assessing aspects of learning, motivation, color discrimination, and short-term memory. Subjects responded for banana-flavored food pellets by pressing response levers and press-plates during daily (MaF) test sessions (50min) and were assigned training scores based upon their individual performance. As reported earlier () beginning around 10months of age, control animals significantly outperformed (had higher training scores than) ketamine-exposed animals for approximately the next 10months. For animals now over 3 and one-half years of age, the cognitive impairments continue to manifest in the ketamine-exposed group as poorer performance in the OTB learning and color and position discrimination tasks, as deficits in accuracy of task performance, but also in response speed. There are also apparent differences in the motivation of these animals which may be impacting OTB performance. These observations demonstrate that a single 24-h episode of ketamine anesthesia, occurring during a sensitive period of brain development, results in very long-lasting deficits in brain function in primates and provide proof-of-concept that general anesthesia during critical periods of brain development can result in subsequent functional deficits. Supported by NICHD, CDER/FDA and NCTR/FDA. JF - Neurotoxicology and Teratology AU - Paule, M G AU - Li, M AU - Allen, R R AU - Liu, F AU - Zou, X AU - Hotchkiss, C AU - Hanig, J P AU - Patterson, T A AU - Slikker, W AU - Wang, C AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, United States, merle.paule@fda.hhs.gov Y1 - 2011/03// PY - 2011 DA - March 2011 PB - Elsevier B.V., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 33 IS - 2 SN - 0892-0362, 0892-0362 KW - Toxicology Abstracts; Environment Abstracts; CSA Neurosciences Abstracts KW - CPR KW - DMTS KW - IRA KW - LTP KW - NMDA KW - OTB KW - PCP KW - PND KW - PR KW - Developmental neurotoxicity KW - Brain function KW - Ketamine anesthesia KW - Cognition KW - Nonhuman primate KW - Age KW - Prenatal experience KW - Operant conditioning KW - Food KW - Short term memory KW - anesthesia KW - Perinatal exposure KW - Discrimination learning KW - Ketamine KW - Macaca mulatta KW - Mortality KW - Intravenous administration KW - Learning KW - discrimination KW - Motivation KW - Training KW - Brain KW - Intrauterine exposure KW - Primates KW - Color KW - Light effects KW - Cell death KW - cognitive ability KW - Anesthesia KW - Cognitive ability KW - Neurotoxicity KW - FDA KW - Critical period KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867747602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Ketamine+anesthesia+during+the+first+week+of+life+can+cause+long-lasting+cognitive+deficits+in+rhesus+monkeys&rft.au=Paule%2C+M+G%3BLi%2C+M%3BAllen%2C+R+R%3BLiu%2C+F%3BZou%2C+X%3BHotchkiss%2C+C%3BHanig%2C+J+P%3BPatterson%2C+T+A%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2011-03-01&rft.volume=33&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2011.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Age; Learning; Intravenous administration; Operant conditioning; Motivation; Food; Brain; Intrauterine exposure; Short term memory; Light effects; Color; Cell death; Anesthesia; Perinatal exposure; Cognitive ability; Discrimination learning; Neurotoxicity; Ketamine; Critical period; Mortality; anesthesia; Prenatal experience; discrimination; cognitive ability; Training; FDA; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.ntt.2011.01.001 ER - TY - JOUR T1 - On the in vivo early toxic properties of A beta sub(25-35) peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression AN - 867747377; 14630114 AB - Amyloid-beta peptide (AI2) deposition is assumed to play a pathogenic role in the brain of Alzheimer's disease patients. To date, the precise mechanisms underlying AI2 toxicity are not fully understood. A recent hypothesis suggesting that the Receptor-for-Advanced-Glycation-End-Products (RAGE)aa trans-membrane protein signaling for oxidative stressais involved in AI2 toxicity is gaining attention. Early AI2 toxicity could indeed help to explain the deleterious events further produced by this molecule in the brain. In this work, we evaluated the pattern of early expression of RAGE in the toxic model induced by AA25a35 in rat CA1 region. Intrahippocampal injections of AI225a35 in rats increased the RAGE expression at 24h post-injection; this event was accompanied by increased components of RAGE downstream signaling in hippocampal cells, such as enhanced expression of the pro-apoptotic factor NF-IoB, increased nitric oxide production, LDH leakage, mitochondrial dysfunction, increased TNF-I- expression, antioxidant genes down-regulation, and augmented neurodegeneration. Our findings support an active role of RAGE during the early stages of AI225a35 toxicity in the hippocampus. JF - Neurotoxicology and Teratology AU - Cuevas, Elvis AU - Lantz, Susan M AU - Toban-Velasco, JCesar AU - Newport, Glenn D AU - Wu, Qiangen AU - Virmani, Ashraf AU - Ali, Syed F AU - Santamaria, Abel AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA, absada@yahoo.com Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 288 EP - 296 PB - Elsevier B.V., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 33 IS - 2 SN - 0892-0362, 0892-0362 KW - Genetics Abstracts; Toxicology Abstracts; Environment Abstracts; CSA Neurosciences Abstracts KW - Alzheimer's disease KW - Animal models KW - Antioxidants KW - Attention KW - Brain KW - Gene expression KW - Hippocampus KW - Leakage KW - Mitochondria KW - Neurodegenerative diseases KW - Nitric oxide KW - Proteins KW - Rats KW - Toxicity KW - downstream KW - G 07880:Human Genetics KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867747377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=On+the+in+vivo+early+toxic+properties+of+A+beta+sub%2825-35%29+peptide+in+the+rat+hippocampus%3A+Involvement+of+the+Receptor-for-Advanced+Glycation-End-Products+and+changes+in+gene+expression&rft.au=Cuevas%2C+Elvis%3BLantz%2C+Susan+M%3BToban-Velasco%2C+JCesar%3BNewport%2C+Glenn+D%3BWu%2C+Qiangen%3BVirmani%2C+Ashraf%3BAli%2C+Syed+F%3BSantamaria%2C+Abel&rft.aulast=Cuevas&rft.aufirst=Elvis&rft.date=2011-03-01&rft.volume=33&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2010.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Gene expression; Neurodegenerative diseases; Leakage; Antioxidants; Hippocampus; Alzheimer's disease; Animal models; Brain; Mitochondria; Nitric oxide; Toxicity; Attention; Rats; downstream; Proteins DO - http://dx.doi.org/10.1016/j.ntt.2010.12.002 ER - TY - JOUR T1 - APPLICATION OF PHASED ARRAY TECHNOLOGY FOR IDENTIFICATION OF LOW FREQUENCY NOISE SOURCES AN - 867737540; 14691693 AB - Noise Induced Hearing Loss (NIHL) is the most common occupational disease in the U.S. with devastating consequences particularly in the mining industry. A study conducted by the National Institute for Occupational Safety and Health (NIOSH) revealed that 90% of coal miners have hearing impairment by age 50, compared to only 10% of those not exposed to occupational noise. According to the Mine Safety and Health Administration (MSHA), Continuous Mining Machine (CM) operators account for 30% of workers exposed to noise doses exceeding the Permissible Exposure Level (PEL). This number becomes more dramatic considering that 49% of the total national underground coal production is extracted using these machines. In this context, NIOSH is conducting research to identify and control dominant noise sources in CMs. Previous noise source identification was performed using a Bruel & Kjaer (B&K) 1.92-m diameter, 42-microphone phased array. These measurements revealed that the impacts from the conveyor chain onto the tail roller, and the impacts from the conveyor chain onto the upper deck are the dominant noise sources at the tail section of the CM. The objectives of the work presented in this paper were: 1) To rank the noise radiated by the different sections of the conveyor, and 2) to determine the effect of a urethane-coated tail roller on the noise radiated by the tail-section. This test was conducted using an Acoustical and Vibrations Engineering Consultants (AVEC) 3.5-m diameter, 121-microphone phased array. The results from this new test show that a urethane-coated tail roller yields reductions in the tail-section of 2 to 8 dB in Sound Pressure Level in the frequency range of 1 kHz to 5 kHz. However, integration of the acoustic maps shows that the front-section and mid-section of the conveyor also contain dominant noise sources. Therefore, a urethane-coated tail roller in combination with a chain with urethane-coated flights that reduces the noise sources in the front and mid sections of the conveyor is required to yield a significant noise reduction on the CM operator's overall exposure. JF - Noise and Vibration in Industry AU - Camargo, H AD - Office of Mine Safety and Health Research, NIOSH, 626 Cochrans Mill Rd, Building 155, Pittsburgh, P.A. 15236, USA Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 61 PB - Multi-Science Publishing Co. Ltd., 107 High St. Brentwood, Essex CM14 4RX England VL - 25 IS - 2 SN - 0950-8163, 0950-8163 KW - Health & Safety Science Abstracts KW - USA KW - Vibration KW - Occupational safety KW - Noise levels KW - Noise reduction KW - Coal KW - Mining KW - Hearing loss KW - Occupational exposure KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867737540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Vibration+in+Industry&rft.atitle=APPLICATION+OF+PHASED+ARRAY+TECHNOLOGY+FOR+IDENTIFICATION+OF+LOW+FREQUENCY+NOISE+SOURCES&rft.au=Camargo%2C+H&rft.aulast=Camargo&rft.aufirst=H&rft.date=2011-03-01&rft.volume=25&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Noise+and+Vibration+in+Industry&rft.issn=09508163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Vibration; Occupational safety; Noise levels; Noise reduction; Hearing loss; Mining; Coal; Occupational exposure; Technology; USA ER - TY - JOUR T1 - Underground mine Refuge Chamber Expectations Training: Program development and evaluation AN - 864393186; 14364506 AB - a-[ordm Refuge chambers are new devices for underground coal mine emergencies. a-[ordm Chambers have 96h of breathable air, water, food, and supplies. a-[ordm Training program prepares miners for psychological and physical effects of chambers. a-[ordm Training imparted realistic views about physical and psychological stresses. a-[ordm Training was well-received by coal miners. Refuge chambers are new devices for underground coal mines that provide approximately 96h of breathable air, water, food, and supplies in the event of an emergency where miners are unable to escape. Researchers at the National Institute for Occupational Safety and Health (NIOSH) developed a training program to prepare miners for what to expect psychologically and physiologically inside of a refuge chamber. The field tests of this training revealed that it was received very positively by miners and helped impart realistic views about the physical discomforts and psychological stresses of being inside a refuge chamber. JF - Safety Science AU - Margolis, Katherine A AU - Westerman, Catherine YKingsley AU - Kowalski-Trakofler, Kathleen M AD - National Institute for Occupational Safety and Health, P.O. Box 18070, Pittsburgh, PA, United States, ckq7@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 522 EP - 530 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 49 IS - 3 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Mining KW - Safety KW - Training KW - Psychological health KW - Physiological health KW - Psychology KW - Occupational safety KW - Physiology KW - Stress KW - Coal KW - Mines KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864393186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=Underground+mine+Refuge+Chamber+Expectations+Training%3A+Program+development+and+evaluation&rft.au=Margolis%2C+Katherine+A%3BWesterman%2C+Catherine+YKingsley%3BKowalski-Trakofler%2C+Kathleen+M&rft.aulast=Margolis&rft.aufirst=Katherine&rft.date=2011-03-01&rft.volume=49&rft.issue=3&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2010.12.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Psychology; Training; Physiology; Occupational safety; Stress; Coal; Mining; Mines DO - http://dx.doi.org/10.1016/j.ssci.2010.12.008 ER - TY - JOUR T1 - Noise-induced hearing loss in agriculture: creating partnerships to overcome barriers and educate the community on prevention. AN - 863416711; pmid-21368439 AB - Noise-induced hearing loss (NIHL) is a common and preventable injury for farmers. Farmers are frequently exposed to excessive noise, ranking among the top three occupations and industries with the highest risk for hearing loss. Use of hearing protection among farmers is not common. Although the age when NIHL begins among farmers is unknown, its prevalence is higher among male adolescents who live and work on farms. The purpose of this paper is to describe how NIOSH created partnerships to promote hearing conservation for this hard-to-reach population. Partnerships included organizations and individuals who were trusted sources of information for the target population, young farmers 14-35 years of age and their families, and those who had linkages in rural communities. NIOSH engaged partners through exhibits and train-the-trainer workshops at state or national conventions. NIOSH workshops included basic information on NIHL as well as information on free or low-lost resources that participants could use in training others at schools and community events. People with hearing conservation expertise have an important role and many opportunities to improve the knowledge and implementation of hearing conservation among those in agriculture. JF - Noise & health AU - Ehlers, Janet J AU - Graydon, Pamela S AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. jehlers@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 142 EP - 146 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Agricultural Workers' Diseases: epidemiology KW - *Agricultural Workers' Diseases: prevention & control KW - Cooperative Behavior KW - *Ear Protective Devices: utilization KW - Female KW - *Health Promotion: methods KW - Hearing Loss, Noise-Induced: epidemiology KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - Male KW - National Institute for Occupational Safety and Health (U.S.) KW - *Occupational Exposure: adverse effects KW - Prevalence KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Noise-induced+hearing+loss+in+agriculture%3A+creating+partnerships+to+overcome+barriers+and+educate+the+community+on+prevention.&rft.au=Ehlers%2C+Janet+J%3BGraydon%2C+Pamela+S&rft.aulast=Ehlers&rft.aufirst=Janet&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Heat and humidity buildup under earmuff-type hearing protectors. AN - 863416709; pmid-21368434 AB - A major barrier to effective wear of hearing protection is comfort. This study examined several comfort indicators in the earmuff-type hearing protectors. Twenty subjects wore hearing protectors instrumented with two different temperature/humidity measurement systems (Omega and iButton) while walking a corridor for about 25 min. The instruments recorded the temperature and humidity every 10 s and their results were compared. In addition, skin surface pH was measured at the ear canal entrance before and after the task. Finally, the subject indicated earmuff comfort at the beginning and end of the session. Earmuff comfort decreased significantly over the course of the walking task. Ear canal pH became slightly less acidic, but the change was not statistically significant. The two temperature/humidity systems provided comparable results. Heat increased at about 0.3°F while humidity built up at about 0.5%/min. However, the study found some limitations on the instrumentation. The complexity of the electrical connections and equipment in the Omega probe system led to loss of three subject's data. The iButton device was more robust, but provided only 256 gradations of temperature and relative humidity. Even with its limitations, the iButton device would be a valuable tool for field studies. The present study showed that the buildup of heat and humidity can be modeled using linear equations. The present study demonstrates that relatively inexpensive tools and a low-exertion task can provide important information about the under-earmuff environment, which can inform assumptions about comfort during use. JF - Noise & health AU - Davis, Rickie R AU - Shaw, Peter B AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Columbia Parkway, Cincinnati, OH 45226, USA. rrd1@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 93 EP - 98 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - *Ear Protective Devices KW - Equipment Design KW - Female KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - Humidity KW - Hydrogen-Ion Concentration KW - Male KW - Middle Aged KW - *Noise, Occupational: adverse effects KW - *Occupational Diseases: prevention & control KW - Temperature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Heat+and+humidity+buildup+under+earmuff-type+hearing+protectors.&rft.au=Davis%2C+Rickie+R%3BShaw%2C+Peter+B&rft.aulast=Davis&rft.aufirst=Rickie&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hearing loss prevention for carpenters: part 1 - using health communication and health promotion models to develop training that works. AN - 863416565; pmid-21368436 AB - In phase 1 of a large multiyear effort, health communication and health promotion models were used to develop a comprehensive hearing loss prevention training program for carpenters. Additionally, a survey was designed to be used as an evaluation instrument. The models informed an iterative research process in which the authors used key informant interviews, focus groups, and early versions of the survey tool to identify critical issues expected to be relevant to the success of the hearing loss prevention training. Commonly held attitudes and beliefs associated with occupational noise exposure and hearing losses, as well as issues associated with the use or non-use of hearing protectors, were identified. The training program was then specifically constructed to positively shape attitudes, beliefs, and behavioral intentions associated with healthy hearing behaviors - especially those associated with appropriate hearing protector use. The goal was to directly address the key issues and overcome the barriers identified during the formative research phase. The survey was finalized using factor analysis methods and repeated pilot testing. It was designed to be used with the training as an evaluation tool and thus could indicate changes over time in attitudes, beliefs, and behavioral intentions regarding hearing loss prevention. Finally, the training program was fine tuned with industry participation so that its delivery would integrate seamlessly into the existing health and safety training provided to apprentice carpenters. In phase 2, reported elsewhere in this volume, the training program and the survey were tested through a demonstration project at two sites. JF - Noise & health AU - Stephenson, Carol Merry AU - Stephenson, Mark R AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, OH 45226-1998, USA. cstephenson@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 113 EP - 121 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Factor Analysis, Statistical KW - Focus Groups KW - *Health Promotion: organization & administration KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - Interviews as Topic KW - *Noise, Occupational: adverse effects KW - *Occupational Diseases: prevention & control KW - *Occupational Exposure: adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Hearing+loss+prevention+for+carpenters%3A+part+1+-+using+health+communication+and+health+promotion+models+to+develop+training+that+works.&rft.au=Stephenson%2C+Carol+Merry%3BStephenson%2C+Mark+R&rft.aulast=Stephenson&rft.aufirst=Carol&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of training on hearing protector attenuation. AN - 863416563; pmid-21368438 AB - The effect of training instruction, whether presented as the manufacturer's printed instructions, a short video training session specific to the product, or as a one-on-one training session was evaluated using four hearing protection devices with eight groups of subjects. Naïve subjects were recruited and tested using three different forms of training: written, video, and individual training. The group averages for A-weighted attenuation were not statistically significant when compared between the video or the written instruction conditions, regardless of presentation order. The experimenter-trained A-weighted attenuations were significantly greater than the written and video instruction for most of the protectors and groups. For each earplug, the noise reduction statistic for A-weighting (NRS A ) and the associated confidence intervals were calculated for the 80 th and 20 th percentiles of protection. Across subject groups for each protector, the differences between NRS A ratings were found to be not statistically significant. Several comparisons evaluating the order of testing, the type of testing, and statistical tests of the performance across the groups are presented. JF - Noise & health AU - Murphy, William J AU - Stephenson, Mark R AU - Byrne, David C AU - Witt, Brad AU - Duran, Jesse AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA. wjm4@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 132 EP - 141 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Audiometry KW - *Ear Protective Devices KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - *Inservice Training KW - National Institute for Occupational Safety and Health (U.S.) KW - *Noise, Occupational: adverse effects KW - *Occupational Diseases: prevention & control KW - Reproducibility of Results KW - Teaching Materials KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Effects+of+training+on+hearing+protector+attenuation.&rft.au=Murphy%2C+William+J%3BStephenson%2C+Mark+R%3BByrne%2C+David+C%3BWitt%2C+Brad%3BDuran%2C+Jesse&rft.aulast=Murphy&rft.aufirst=William&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hearing loss prevention for carpenters: part 2 - demonstration projects using individualized and group training. AN - 863416556; pmid-21368437 AB - Two demonstration projects were conducted to evaluate the effectiveness of a comprehensive training program for carpenters. This training was paired with audiometry and counseling and a survey of attitudes and beliefs in hearing loss prevention. All participants received hearing tests, multimedia instruction on occupational noise exposure/hearing loss, and instruction and practice in using a diverse selection of hearing protection devices (HPDs). A total of 103 apprentice carpenters participated in the Year 1 training, were given a large supply of these HPDs, and instructions on how to get additional free supplies if they ran out during the 1-year interval between initial and follow-up training. Forty-two participants responded to the survey a second time a year later and completed the Year 2 training. Significant test-retest differences were found between the pre-training and the post-training survey scores. Both forms of instruction (individual versus group) produced equivalent outcomes. The results indicated that training was able to bring all apprentice participants up to the same desired level with regard to attitudes, beliefs, and behavioral intentions to use hearing protection properly. It was concluded that the health communication models used to develop the educational and training materials for this effort were extremely effective. JF - Noise & health AU - Stephenson, Mark R AU - Shaw, Peter B AU - Stephenson, Carol Merry AU - Graydon, Pamela S AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226-1998, USA. mstephenson@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 122 EP - 131 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Audiometry KW - *Ear Protective Devices KW - Educational Measurement KW - Female KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - *Inservice Training KW - Logistic Models KW - Male KW - Middle Aged KW - *Noise, Occupational: adverse effects KW - *Occupational Diseases: prevention & control KW - *Occupational Exposure: adverse effects KW - Teaching Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Hearing+loss+prevention+for+carpenters%3A+part+2+-+demonstration+projects+using+individualized+and+group+training.&rft.au=Stephenson%2C+Mark+R%3BShaw%2C+Peter+B%3BStephenson%2C+Carol+Merry%3BGraydon%2C+Pamela+S&rft.aulast=Stephenson&rft.aufirst=Mark&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Relationship between comfort and attenuation measurements for two types of earplugs. AN - 863416531; pmid-21368433 AB - Noise-induced hearing loss is almost always preventable if properly fitted hearing protectors are worn to reduce exposure. Many individuals choose not to wear hearing protection because it may interfere with effective communication in the workplace or it may be uncomfortable. Hearing protector comfort has not received the same amount of attention as noise reduction capability. The present study was conducted to evaluate the comfort level of two different types of insert earplugs as well as the attenuation levels achieved by the earplugs. Attenuation levels were obtained with a commercially available earplug fit-test system, and the comfort ratings were obtained by questionnaire. The primary research objective was to determine whether hearing protector comfort was related to measured attenuation values. A linear mixed effects model provided evidence for an inverse relationship between comfort and attenuation. JF - Noise & health AU - Byrne, David C AU - Davis, Rickie R AU - Shaw, Peter B AU - Specht, Burgundy M AU - Holland, Amy N AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA. dbyrne@cdc.gov Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 86 EP - 92 VL - 13 IS - 51 SN - 1463-1741, 1463-1741 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Ear Protective Devices KW - Female KW - *Hearing Loss, Noise-Induced: prevention & control KW - Humans KW - Linear Models KW - Male KW - Middle Aged KW - *Noise, Occupational: adverse effects KW - *Occupational Diseases: prevention & control KW - *Occupational Exposure: adverse effects KW - Prosthesis Design KW - Prosthesis Fitting KW - Questionnaires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/863416531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+%26+health&rft.atitle=Relationship+between+comfort+and+attenuation+measurements+for+two+types+of+earplugs.&rft.au=Byrne%2C+David+C%3BDavis%2C+Rickie+R%3BShaw%2C+Peter+B%3BSpecht%2C+Burgundy+M%3BHolland%2C+Amy+N&rft.aulast=Byrne&rft.aufirst=David&rft.date=2011-03-01&rft.volume=13&rft.issue=51&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Noise+%26+health&rft.issn=14631741&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Assessing the risk to firefighters from chemical vapors and gases during vehicle fire suppression. AN - 856773414; 21274476 AB - Despite the frequent occurrence of vehicle fires, very few studies investigating firefighters' potential inhalation exposures during vehicle fire suppression have been conducted. In this paper, we present an assessment of firefighters' health risk from vehicle fire suppression that accounts for the mixture of gases and vapors likely to be found in these fires. Summa canisters were used to collect emissions from the engine and cabin fires of a single vehicle and were analyzed for 75 volatile organic compounds (VOCs). Firefighters' breathing zone concentrations (BZCs) of aromatic hydrocarbons, aldehydes, isocyanates, and carbon monoxide were measured during the suppression of three vehicle fires. The Summa canister and BZC data were used to develop a simple model for predicting BZCs for the compounds that were not measured in the firefighters' breathing zones. Hazard quotients (HQs) were calculated by dividing the predicted and measured BZCs by the most conservative short-term exposure limits (STELs) or ceiling limits. Hazard indices (HIs) were determined by adding HQs for compounds grouped by the target organ for acute health effects. Any HIs above unity represented unacceptable risks. According to this mixture analysis, the estimated 95(th) percentile of the exposure distribution for the study population represents ≥ 9.2 times the acceptable level of risk to the respiratory tract and eyes. Furthermore, chemicals known or reasonably anticipated to be human carcinogens contributed to > 45% of these HIs. While STELs are not usually based on carcinogenicity, maintaining exposures below STELs may protect individuals from the biological stress that could result from short-term exposures to carcinogens over time. Although vehicle fires are suppressed quickly (<10 min), this assessment suggests that firefighters have the potential to be overexposed to acute toxins during vehicle fire suppression and should therefore wear self-contained breathing apparatus at all times during vehicle fire response. JF - Journal of environmental monitoring : JEM AU - Fent, Kenneth W AU - Evans, Douglas E AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Lieutenant, US Public Health Service, Industrial Hygienist, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (CDC/NIOSH), Cincinnati, OH 45226, USA. kfent@cdc.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 536 EP - 543 VL - 13 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Gases KW - Volatile Organic Compounds KW - Index Medicus KW - Humans KW - Male KW - Female KW - Risk Assessment KW - Fires KW - Gases -- analysis KW - Air Pollutants, Occupational -- analysis KW - Volatile Organic Compounds -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856773414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Assessing+the+risk+to+firefighters+from+chemical+vapors+and+gases+during+vehicle+fire+suppression.&rft.au=Fent%2C+Kenneth+W%3BEvans%2C+Douglas+E&rft.aulast=Fent&rft.aufirst=Kenneth&rft.date=2011-03-01&rft.volume=13&rft.issue=3&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=1464-0333&rft_id=info:doi/10.1039%2Fc0em00591f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-20 N1 - Date created - 2011-03-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1039/c0em00591f ER - TY - JOUR T1 - Detection of type III secretion system virulence and mutations in gyrA and parC genes among quinolone-resistant strains of Pseudomonas aeruginosa isolated from imported shrimp. AN - 856173056; 21117986 AB - Twenty Pseudomonas aeruginosa isolates were recovered from imported frozen raw shrimp sold in the United States. Isolates were tested for antimicrobial susceptibility to quinolones and analyzed for mutations in quinolone resistance-determining regions, presence of type III secretion system genes, and genetic relatedness using pulsed-field gel electrophoresis. All isolates were resistant to nalidixic acid. Polymerase chain reaction assays detected exoS, exoT, exoU, and exoY among isolates. Eight unique pulsed-field gel electrophoresis clusters were generated. Mutations were found in gyrA at codon 83 (Ile to Thr) and in parC at codon 87 (Leu to Ser). Together, these findings reveal that imported shrimp may harbor virulent and quinolone-resistant strains of P. aeruginosa. JF - Foodborne pathogens and disease AU - Tran, Quynh T AU - Nawaz, Mohamed S AU - Deck, Joanna AU - Foley, Steven AU - Nguyen, Kiet AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. qttran@mdanderson.org Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 451 EP - 453 VL - 8 IS - 3 KW - Anti-Infective Agents KW - 0 KW - Bacterial Secretion Systems KW - DNA, Bacterial KW - Membrane Transport Proteins KW - Quinolones KW - Nalidixic Acid KW - 3B91HWA56M KW - DNA Topoisomerase IV KW - EC 5.99.1.- KW - DNA Gyrase KW - EC 5.99.1.3 KW - Index Medicus KW - United States KW - Animals KW - Nalidixic Acid -- pharmacology KW - DNA, Bacterial -- analysis KW - Virulence KW - Bacterial Secretion Systems -- genetics KW - DNA, Bacterial -- genetics KW - Polymerase Chain Reaction -- methods KW - Drug Resistance, Bacterial -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Membrane Transport Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Microbial Sensitivity Tests KW - Mutation KW - Amino Acid Substitution KW - Quinolones -- pharmacology KW - Pseudomonas aeruginosa -- pathogenicity KW - Pseudomonas aeruginosa -- isolation & purification KW - Pseudomonas aeruginosa -- genetics KW - Penaeidae -- microbiology KW - DNA Gyrase -- genetics KW - Pseudomonas aeruginosa -- drug effects KW - Anti-Infective Agents -- pharmacology KW - DNA Topoisomerase IV -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856173056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Detection+of+type+III+secretion+system+virulence+and+mutations+in+gyrA+and+parC+genes+among+quinolone-resistant+strains+of+Pseudomonas+aeruginosa+isolated+from+imported+shrimp.&rft.au=Tran%2C+Quynh+T%3BNawaz%2C+Mohamed+S%3BDeck%2C+Joanna%3BFoley%2C+Steven%3BNguyen%2C+Kiet%3BCerniglia%2C+Carl+E&rft.aulast=Tran&rft.aufirst=Quynh&rft.date=2011-03-01&rft.volume=8&rft.issue=3&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2010.0687 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-19 N1 - Date created - 2011-03-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/fpd.2010.0687 ER - TY - JOUR T1 - Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet. AN - 855201389; 20938992 AB - A methyl-deficient diet induces liver injury similar to human nonalcoholic steatohepatitis, one of the main risk factors for the development of hepatocellular carcinoma. Previous studies have demonstrated that this diet perturbs DNA methylation by causing a profound loss of global cytosine methylation, predominantly at heavily methylated repetitive sequences. However, whether methyl deficiency affects the methylation status of gene promoters has not been explored. Mouse gene expression and CpG island microarrays were used to characterize the gene expression and CpG island methylation profiles in the livers of C57BL/6J mice fed a methyl-deficient diet. We detected 164 genes that were differentially expressed and exhibited an inverse relationship between the gene expression and the extent of CpG island methylation. Furthermore, these genes were associated with altered lipid and glucose metabolism, DNA damage and repair, apoptosis, the development of fibrosis, and liver tissue remodeling. Although there were both increased and decreased levels of CpG island methylation, the number of hypomethylated genes was substantially greater than the number of hypermethylated genes. The results this study demonstrate that pairing methylation profiles with gene expression profiles is a powerful approach to identify dysregulated high-priority fundamental pathophysiological pathways associated with disease development. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Molecular nutrition & food research AU - Tryndyak, Volodymyr P AU - Han, Tao AU - Muskhelishvili, Levan AU - Fuscoe, James C AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 411 EP - 418 VL - 55 IS - 3 KW - Index Medicus KW - Animals KW - Liver Neoplasms, Experimental -- genetics KW - Fatty Liver -- etiology KW - Oligonucleotide Array Sequence Analysis KW - DNA Damage KW - Mice KW - Non-alcoholic Fatty Liver Disease KW - Gene Expression Regulation, Neoplastic KW - Carcinoma, Hepatocellular -- etiology KW - Liver Neoplasms, Experimental -- etiology KW - Carcinoma, Hepatocellular -- genetics KW - CpG Islands KW - Mice, Inbred C57BL KW - Fatty Liver -- physiopathology KW - Diet KW - Male KW - Gene Expression Profiling KW - Malnutrition -- complications KW - DNA Methylation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855201389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=Coupling+global+methylation+and+gene+expression+profiles+reveal+key+pathophysiological+events+in+liver+injury+induced+by+a+methyl-deficient+diet.&rft.au=Tryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BMuskhelishvili%2C+Levan%3BFuscoe%2C+James+C%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2011-03-01&rft.volume=55&rft.issue=3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=1613-4133&rft_id=info:doi/10.1002%2Fmnfr.201000300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-16 N1 - Date created - 2011-03-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mnfr.201000300 ER - TY - JOUR T1 - Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay. AN - 853996683; 20980367 AB - Cigarette smoke condensate (CSC) is genotoxic in nearly all assays in which it has been tested. In this study, we investigated the mutagenicity of 11 CSCs using the microwell and soft-agar versions of the mouse lymphoma assay (MLA). These CSCs were prepared from commercial or experimental cigarettes, 10 of them were produced using International Organisation for Standardisation (ISO) conditions and one CSC was generated using intense Massachusetts Department of Public Health (MDPH) conditions. In the presence of rat liver S9, the L5178Y/Tk(+/-) mouse lymphoma cells were treated with 11 CSCs at different concentrations (25-200 μg/ml) for 4 h. All CSCs resulted in dose-dependent increases of both cytotoxicity and mutagenicity in both versions of the MLA. The mutagenic potencies of the CSCs were calculated as mutant frequency per microgram CSC from the slope of the linear regression of the dose-response curves and showed no correlations with the tar yield of the cigarette or nicotine concentrations of the CSCs. Comparing two CSCs produced from the same commercial cigarettes using two different smoking conditions, the one generated under ISO conditions was more mutagenic than the other generated under intense conditions on a per microgram CSC basis. We also examined the loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 for the mutants induced by 11 CSCs. The most common type of mutation observed was LOH with chromosome damage spanning less than ∼34 Mbp. These results indicate that the MLA identifies different genotoxic potencies among a variety of CSCs and that the results from both versions of the assay are comparable. JF - Mutagenesis AU - Guo, Xiaoqing AU - Verkler, Tracie L AU - Chen, Ying AU - Richter, Patricia A AU - Polzin, Gregory M AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 273 EP - 281 VL - 26 IS - 2 KW - Mutagens KW - 0 KW - Smoke KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Microsatellite Repeats -- genetics KW - Dose-Response Relationship, Drug KW - Smoke -- analysis KW - Mice KW - Cell Line, Tumor KW - Lymphoma -- pathology KW - Mutation KW - Male KW - Thymidine Kinase -- genetics KW - Tobacco -- toxicity KW - Mutagenicity Tests -- methods KW - Tobacco -- chemistry KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853996683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Mutagenicity+of+11+cigarette+smoke+condensates+in+two+versions+of+the+mouse+lymphoma+assay.&rft.au=Guo%2C+Xiaoqing%3BVerkler%2C+Tracie+L%3BChen%2C+Ying%3BRichter%2C+Patricia+A%3BPolzin%2C+Gregory+M%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2011-03-01&rft.volume=26&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeq083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-19 N1 - Date created - 2011-02-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/geq083 ER - TY - JOUR T1 - Plasmid-mediated quinolone resistance in pseudomonas putida isolates from imported shrimp. AN - 853994786; 21193671 AB - Fourteen quinolone-resistant Pseudomonas putida isolates were recovered from imported frozen shrimp sold in the United States. Two isolates harbored plasmids with qnrA and qnrB genes. PCR and DNA sequencing of quinolone resistance-determining regions identified novel substitutions in GyrA (His139→Glu and Thr128→Ala) and GyrB (Thr442→Asn, Gly470→Ala, and Ile487→Pro) and previously reported substitutions in GyrB (Asp489→Glu) and ParC (Thr105→Pro). JF - Applied and environmental microbiology AU - Tran, Quynh T AU - Nawaz, Mohamed S AU - Deck, Joanna AU - Nguyen, Kiet T AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. quynhtien.n.tran@gmail.com Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 1885 EP - 1887 VL - 77 IS - 5 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Quinolones KW - DNA Topoisomerase IV KW - EC 5.99.1.- KW - DNA Gyrase KW - EC 5.99.1.3 KW - Index Medicus KW - United States KW - Molecular Typing KW - Sequence Analysis, DNA KW - Bacterial Typing Techniques KW - DNA Topoisomerase IV -- genetics KW - Mutation, Missense KW - Polymerase Chain Reaction KW - DNA Gyrase -- genetics KW - Amino Acid Substitution -- genetics KW - DNA, Bacterial -- chemistry KW - DNA, Bacterial -- genetics KW - Electrophoresis, Gel, Pulsed-Field KW - Cluster Analysis KW - Microbial Sensitivity Tests KW - Pseudomonas putida -- classification KW - Drug Resistance, Bacterial KW - Anti-Bacterial Agents -- pharmacology KW - Seafood -- microbiology KW - Pseudomonas putida -- genetics KW - Plasmids KW - Pseudomonas putida -- isolation & purification KW - Pseudomonas putida -- drug effects KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853994786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Plasmid-mediated+quinolone+resistance+in+pseudomonas+putida+isolates+from+imported+shrimp.&rft.au=Tran%2C+Quynh+T%3BNawaz%2C+Mohamed+S%3BDeck%2C+Joanna%3BNguyen%2C+Kiet+T%3BCerniglia%2C+Carl+E&rft.aulast=Tran&rft.aufirst=Quynh&rft.date=2011-03-01&rft.volume=77&rft.issue=5&rft.spage=1885&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.01176-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-23 N1 - Date created - 2011-02-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Antimicrob Chemother. 2005 Sep;56(3):463-9 [16020539] Antimicrob Agents Chemother. 2005 Aug;49(8):3523-5 [16048974] Sci Total Environ. 2005 Oct 15;349(1-3):95-105 [16198672] J Clin Microbiol. 2005 Oct;43(10):5316-8 [16208007] Antimicrob Agents Chemother. 2006 Apr;50(4):1178-82 [16569827] Antimicrob Agents Chemother. 2006 Aug;50(8):2872-4 [16870791] J Antimicrob Chemother. 2007 Aug;60(2):394-7 [17561500] J Antimicrob Chemother. 2008 Jun;61(6):1234-9 [18356152] Vet Microbiol. 2008 Sep 18;131(1-2):164-72 [18395369] Antimicrob Agents Chemother. 2008 Dec;52(12):4268-73 [18809939] Nucleic Acids Res. 2009 Jan;37(Database issue):D483-8 [18978025] Clin Infect Dis. 2009 Oct 15;49(8):1248-53 [19772389] Acta Vet Scand Suppl. 1999;92:29-36 [10783715] Appl Environ Microbiol. 2000 Sep;66(9):3883-90 [10966404] Antimicrob Agents Chemother. 2001 Aug;45(8):2263-8 [11451683] Mar Pollut Bull. 2003 Jan;46(1):81-90 [12535973] Microb Drug Resist. 2003 Fall;9(3):265-71 [12959405] J Hosp Infect. 2004 May;57(1):88-91 [15142722] J Antimicrob Chemother. 2004 Aug;54(2):311-20 [15215223] J Antimicrob Chemother. 1993 May;31(5):627-35 [8335494] J Clin Microbiol. 1996 Apr;34(4):908-11 [8815106] Antimicrob Agents Chemother. 1996 Apr;40(4):879-85 [8849244] Eur J Clin Microbiol Infect Dis. 1996 Jul;15(7):610-5 [8874083] J Antimicrob Chemother. 1996 Sep;38(3):443-55 [8889719] Lancet. 1998 Mar 14;351(9105):797-9 [9519952] Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):642-4 [9832266] Antimicrob Agents Chemother. 1999 Feb;43(2):406-9 [9925546] Antimicrob Agents Chemother. 2005 Feb;49(2):801-3 [15673773] J Antimicrob Chemother. 2005 Oct;56(4):643-7 [16046469] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.01176-10 ER - TY - JOUR T1 - Similarities and differences in the expression of drug-metabolizing enzymes between human hepatic cell lines and primary human hepatocytes. AN - 852910465; 21149542 AB - In addition to primary human hepatocytes, hepatoma cell lines, and transfected nonhepatoma, hepatic cell lines have been used for pharmacological and toxicological studies. However, a systematic evaluation and a general report of the gene expression spectra of drug-metabolizing enzymes and transporters (DMETs) in these in vitro systems are not currently available. To fill this information gap and to provide references for future studies, we systematically characterized the basal gene expression profiles of 251 drug-metabolizing enzymes in untreated primary human hepatocytes from six donors, four commonly used hepatoma cell lines (HepG2, Huh7, SK-Hep-1, and Hep3B), and one transfected human liver epithelial cell line. A large variation in DMET expression spectra was observed between hepatic cell lines and primary hepatocytes, with the complete absence or much lower abundance of certain DMETs in hepatic cell lines. Furthermore, the basal DMET expression spectra of five hepatic cell lines are summarized, providing references for researchers to choose carefully appropriate in vitro models for their studies of drug metabolism and toxicity, especially for studies with drugs in which toxicities are mediated through the formation of reactive metabolites. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Guo, Lei AU - Dial, Stacey AU - Shi, Leming AU - Branham, William AU - Liu, Jie AU - Fang, Jia-Long AU - Green, Bridgett AU - Deng, Helen AU - Kaput, Jim AU - Ning, Baitang AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 528 EP - 538 VL - 39 IS - 3 KW - Membrane Transport Proteins KW - 0 KW - RNA, Messenger KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Algorithms KW - Biological Transport KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Profiling KW - Inactivation, Metabolic KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Drug Evaluation, Preclinical -- methods KW - Membrane Transport Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Cell Line KW - Gene Expression Regulation, Enzymologic KW - Hepatocytes -- enzymology KW - Pharmacokinetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/852910465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=Similarities+and+differences+in+the+expression+of+drug-metabolizing+enzymes+between+human+hepatic+cell+lines+and+primary+human+hepatocytes.&rft.au=Guo%2C+Lei%3BDial%2C+Stacey%3BShi%2C+Leming%3BBranham%2C+William%3BLiu%2C+Jie%3BFang%2C+Jia-Long%3BGreen%2C+Bridgett%3BDeng%2C+Helen%3BKaput%2C+Jim%3BNing%2C+Baitang&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2011-03-01&rft.volume=39&rft.issue=3&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.110.035873 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-14 N1 - Date created - 2011-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 1997 Jun;105 Suppl 4:829-35 [9255568] Curr Drug Metab. 2003 Aug;4(4):292-312 [12871046] Toxicol Lett. 2005 Dec 30;160(1):22-33 [16054781] Drug Metab Dispos. 2006 Jan;34(1):75-83 [16204462] Drug Metab Rev. 2007;39(1):159-234 [17364884] Chem Biol Interact. 2007 May 20;168(1):2-15 [17208208] Toxicol Appl Pharmacol. 2007 Jul 1;222(1):42-56 [17512962] Xenobiotica. 2007 Oct-Nov;37(10-11):1196-224 [17968743] Toxicol In Vitro. 2007 Dec;21(8):1581-91 [17637504] Curr Drug Metab. 2008 Jan;9(1):1-11 [18220566] Toxicol Sci. 2008 Jun;103(2):335-45 [18344530] Hepatology. 2003 Dec;38(6):1331-47 [14647040] Biochim Biophys Acta. 2004 Feb 2;1644(1):37-45 [14741743] Toxicology. 2004 May 20;198(1-3):315-28 [15138058] FEBS Lett. 1988 Dec 5;241(1-2):15-8 [2848717] Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):5123-7 [7685115] FASEB J. 1996 Feb;10(2):267-82 [8641560] Methods Enzymol. 1996;272:388-401 [8791798] J Clin Pharmacol. 2008 Jun;48(6):662-70 [18378963] PLoS Biol. 2008 May 6;6(5):e107 [18462017] Trends Genet. 2008 Aug;24(8):408-15 [18597885] J Pharmacol Sci. 2008 Sep;108(1):79-88 [18776712] Curr Drug Metab. 2008 Oct;9(8):738-84 [18855611] Curr Drug Metab. 2008 Nov;9(9):928-39 [18991590] Drug Metab Rev. 2009;41(2):89-295 [19514967] J Hazard Mater. 2009 Oct 15;170(1):351-6 [19477068] Bioorg Med Chem. 2009 Nov 1;17(21):7562-71 [19783149] Toxicol Appl Pharmacol. 2010 May 1;244(3):336-43 [20132835] Toxicol Sci. 2010 May;115(1):66-79 [20106945] Drug Metab Dispos. 2010 Jun;38(6):988-94 [20228232] Genome Res. 2010 Aug;20(8):1020-36 [20538623] Clin Cancer Res. 2000 Apr;6(4):1255-8 [10778948] Cancer Res. 2000 Dec 15;60(24):6921-6 [11156391] Cell Physiol Biochem. 2001;11(2):105-14 [11275689] Eur J Pharm Sci. 2001 Jul;13(4):343-68 [11408150] Arch Biochem Biophys. 2001 Sep 15;393(2):308-15 [11556818] Am J Health Syst Pharm. 2002 Nov 1;59(21):2061-9 [12434718] Toxicol Appl Pharmacol. 2003 Jun 15;189(3):233-46 [12791308] Drug Metab Dispos. 2003 Aug;31(8):1035-42 [12867492] FEBS Lett. 1998 Jul 17;431(2):227-30 [9708908] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/dmd.110.035873 ER - TY - JOUR T1 - Do interleukin polymorphisms play a role in the prevention of colorectal adenoma recurrence by dietary flavonols? AN - 847598532; 21160427 AB - Chemopreventive dietary compounds, such as flavonols, may inhibit colorectal carcinogenesis partly by altering cytokine expression and attenuating inflammation. Single nucleotide polymorphisms (SNPs) in the promoter regions of genes encoding cytokines may influence flavonol-induced changes in cytokine expression and consequently cancer risk. Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for the association between SNPs of interleukin (IL)-1β, 6, 8, and 10 alone or combined with flavonol intake or serum IL concentration changes, and adenoma recurrence in 808 participants from the intervention arm of the Polyp Prevention Trial, a 4-year intervention study evaluating the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. Overall, SNPs in genes encoding IL-1β, 6, 8, and 10 were not associated with their corresponding serum concentrations or adenoma recurrence. However, individuals homozygous for IL-10 -592 C (OR=2.23, 95% CI: 1.07-4.66, P(interaction)=0.03) orIL-10 -819 C (OR=2.18, 95% CI: 1.05-4.51, P(interaction)=0.05) had an elevated risk of high-risk adenoma recurrence when their serum IL-10 concentrations increased during the trial. In addition, IL-6 -174 GG in combination with above median flavonol intake (OR=0.14, 95% CI: 0.03-0.66) or with decreased IL-6 concentrations (OR=0.14, 95% CI: 0.03-0.65) reduced the risk of advanced adenoma recurrence, although the interaction term was not statistically significant. In conclusion, our results suggest that IL SNPs, in combination with a flavonol-rich diet or decreased serum IL, may lower the risk of adenoma recurrence. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Bobe, Gerd AU - Murphy, Gwen AU - Albert, Paul S AU - Sansbury, Leah B AU - Young, Matthew R AU - Lanza, Elaine AU - Schatzkin, Arthur AU - Colburn, Nancy H AU - Cross, Amanda J AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. gerd.bobe@oregonstate.edu Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 86 EP - 95 VL - 20 IS - 2 KW - Flavonols KW - 0 KW - Interleukin-6 KW - Interleukins KW - Interleukin-10 KW - 130068-27-8 KW - Index Medicus KW - Humans KW - Interleukin-6 -- genetics KW - Prognosis KW - Aged KW - Middle Aged KW - Interleukin-10 -- genetics KW - Male KW - Female KW - Colorectal Neoplasms -- genetics KW - Polymorphism, Single Nucleotide -- physiology KW - Interleukins -- genetics KW - Neoplasm Recurrence, Local -- prevention & control KW - Flavonols -- therapeutic use KW - Colorectal Neoplasms -- pathology KW - Adenoma -- prevention & control KW - Diet KW - Adenoma -- genetics KW - Adenoma -- pathology KW - Colorectal Neoplasms -- prevention & control KW - Neoplasm Recurrence, Local -- genetics KW - Neoplasm Recurrence, Local -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847598532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Do+interleukin+polymorphisms+play+a+role+in+the+prevention+of+colorectal+adenoma+recurrence+by+dietary+flavonols%3F&rft.au=Bobe%2C+Gerd%3BMurphy%2C+Gwen%3BAlbert%2C+Paul+S%3BSansbury%2C+Leah+B%3BYoung%2C+Matthew+R%3BLanza%2C+Elaine%3BSchatzkin%2C+Arthur%3BColburn%2C+Nancy+H%3BCross%2C+Amanda+J&rft.aulast=Bobe&rft.aufirst=Gerd&rft.date=2011-03-01&rft.volume=20&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e3283429e45 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-03 N1 - Date created - 2011-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Invest. 1998 Oct 1;102(7):1369-76 [9769329] Cancer Epidemiol Biomarkers Prev. 1996 May;5(5):385-92 [9162305] J Nutr Biochem. 2005 Mar;16(3):155-62 [15741050] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2359-65 [16214917] Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):494-501 [16537707] Eur J Cancer Prev. 2006 Jun;15(3):249-53 [16679868] Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1126-31 [16775170] Biochem Pharmacol. 2006 Oct 16;72(8):1010-21 [16934226] J Agric Food Chem. 2006 Dec 27;54(26):9798-804 [17177504] Cancer Res. 2007 Feb 1;67(3):1062-71 [17283139] J Nutr. 2007 May;137(5):1244-52 [17449588] J Clin Invest. 2007 May;117(5):1175-83 [17476347] Eur J Cancer. 2007 May;43(8):1283-9 [17446060] Oncol Rep. 2007 Aug;18(2):473-81 [17611673] Mol Cancer Ther. 2007 Sep;6(9):2544-53 [17876051] Int J Cancer. 2007 Nov 1;121(9):2001-4 [17640058] Cancer Causes Control. 2007 Dec;18(10):1095-105 [17694420] Anticancer Res. 2007 Sep-Oct;27(5B):3577-87 [17972520] Cancer Res. 2008 Feb 1;68(3):946-55 [18245498] J Nutr. 2008 Apr;138(4):753-60 [18356331] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1344-53 [18559549] Carcinogenesis. 2008 Aug;29(8):1572-80 [18628251] Clin Cancer Res. 2008 Nov 1;14(21):6735-41 [18980965] J Cell Biochem. 2009 Jan 1;106(1):73-82 [19009557] Cancer Lett. 2009 Mar 8;275(1):17-26 [18995957] Cancer Cell. 2009 Feb 3;15(2):103-13 [19185845] Int J Colorectal Dis. 2009 Mar;24(3):289-94 [18704460] Respir Med. 2009 Mar;103(3):364-72 [19010653] Food Chem Toxicol. 2009 Apr;47(4):809-12 [19271315] Eur J Gynaecol Oncol. 2009;30(1):60-4 [19317259] Clin Cancer Res. 2009 Sep 15;15(18):5878-87 [19737943] Nutr Cancer. 2009;61(4):554-63 [19838928] Cancer Causes Control. 2009 Nov;20(9):1739-51 [19760027] Phytother Res. 2010 Jan;24(1):119-28 [19504466] Carcinogenesis. 2010 Jan;31(1):37-49 [19955394] J Nutr. 2010 Feb;140(2):278-84 [20032478] Cancer Prev Res (Phila). 2010 Jun;3(6):764-75 [20484173] J Biol Chem. 1999 Nov 5;274(45):32091-8 [10542243] Public Health Nutr. 1999 Dec;2(4):565-9 [10656476] N Engl J Med. 2000 Apr 20;342(16):1149-55 [10770979] J Biol Chem. 2000 Jun 16;275(24):18138-44 [10747905] Mol Diagn. 2000 Dec;5(4):329-40 [11172497] Carcinogenesis. 2001 Apr;22(4):665-71 [11285204] Am J Clin Nutr. 2001 Sep;74(3):387-401 [11522565] Biochem Biophys Res Commun. 2002 Jan 11;290(1):469-74 [11779194] Cell Mol Life Sci. 2002 Mar;59(3):560-9 [11964134] Genes Immun. 2002 Nov;3(7):407-13 [12424622] Gastroenterology. 2002 Dec;123(6):1793-803 [12454835] Immunogenetics. 2003 Dec;55(9):629-32 [14605776] Genes Immun. 2004 Jun;5(4):274-82 [15085176] Gut. 2004 Aug;53(8):1082-9 [15247172] Epidemiology. 1990 Jan;1(1):58-64 [2081241] Arthritis Rheum. 1999 Jun;42(6):1101-8 [10366102] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e3283429e45 ER - TY - JOUR T1 - Targeting IL-13Rα2 in human pancreatic ductal adenocarcinoma with combination therapy of IL-13-PE and gemcitabine. AN - 822554763; 20473925 AB - Pancreatic cancer is an aggressive disease with only limited therapeutic options available. We have identified that 71% pancreatic ductal adenocarcinoma (PDA) express high levels of IL-13Rα2, a high-affinity receptor for IL-13. To target IL-13Rα2, we have developed a recombinant immunotoxin, which is a fusion of IL-13 and Pseudomonas exotoxin (IL-13-PE). Since IL-13-PE and a commonly used cytotoxic drug gemcitabine act by a different mechanism, we hypothesized that they synergize in mediating antitumor response. Both IL-13-PE and gemcitabine-mediated cytotoxicity to two pancreatic cancer cell lines and when combined synergistic cytotoxicity was observed. This synergism was also demonstrated in vivo in an orthotopic mouse model of human PDA. IL-13-PE and gemcitabine showed complete eradiation of tumors as assessed by whole body imaging of GFP-transfected tumors in 57% of mice in an early cancer model resulting into prolongation of survival. In contrast, monotherapy with either agent did not produce complete eradiation, but tumor volumes were significantly decreased. In advanced PDA model, combination therapy also produced dramatic reduction in tumor growth and enhanced survival compared to animals treated with either agent alone. When IL-13Rα2 was knocked-down by RNAi prior to tumor implantation, IL-13-PE and gemcitabine did not synergize indicating that IL-13Rα2 is essential. Mechanistically, gemcitabine increased IL-13Rα2 expression in vitro and in vivo, which resulted in a synergism of combination therapy. Interestingly, PDA cancer stem cells were resistant to gemcitabine, but not to IL-13-PE. These results suggest that combination therapy with IL-13-PE and gemcitabine may be a useful strategy for PDA therapy. Copyright © 2010 UICC. JF - International journal of cancer AU - Fujisawa, Toshio AU - Nakashima, Hideyuki AU - Nakajima, Atsushi AU - Joshi, Bharat H AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD, USA. Y1 - 2011/03/01/ PY - 2011 DA - 2011 Mar 01 SP - 1221 EP - 1231 VL - 128 IS - 5 KW - Interleukin-13 KW - 0 KW - Interleukin-13 Receptor alpha2 Subunit KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Index Medicus KW - Interleukin-13 -- administration & dosage KW - In Situ Nick-End Labeling KW - Animals KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Reverse Transcriptase Polymerase Chain Reaction KW - Immunohistochemistry KW - Interleukin-13 Receptor alpha2 Subunit -- drug effects KW - Carcinoma, Pancreatic Ductal -- drug therapy KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822554763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Targeting+IL-13R%CE%B12+in+human+pancreatic+ductal+adenocarcinoma+with+combination+therapy+of+IL-13-PE+and+gemcitabine.&rft.au=Fujisawa%2C+Toshio%3BNakashima%2C+Hideyuki%3BNakajima%2C+Atsushi%3BJoshi%2C+Bharat+H%3BPuri%2C+Raj+K&rft.aulast=Fujisawa&rft.aufirst=Toshio&rft.date=2011-03-01&rft.volume=128&rft.issue=5&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25437 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-01 N1 - Date created - 2011-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25437 ER - TY - JOUR T1 - SOT at 50: A Proud Legacy, A Vibrant Future AN - 1677912321; 14606811 AB - Abstract not available. JF - Environmental Health Perspectives AU - Birnbaum, Linda S AD - Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina birnbaumls@niehs.nih.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - A110 EP - A111 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Legacy KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677912321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=SOT+at+50%3A+A+Proud+Legacy%2C+A+Vibrant+Future&rft.au=Birnbaum%2C+Linda+S&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2011-03-01&rft.volume=119&rft.issue=3&rft.spage=A110&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1103511 ER - TY - JOUR T1 - Substance Abuse Counselors' Implementation of Tobacco Cessation Guidelines AN - 1115556192; 21615002 AB - This study assessed the extent of implementation of the Public Health Service tobacco cessation guidelines among a national sample of counselors working in five different types of substance abuse treatment programs. Further, we identified implementation patterns among counselors using cluster analysis and considered differences in counselor characteristics based on their cluster membership. Data were obtained from the 2008 Managing Effective Relationships in Treatment Services (MERITS I) project. Counselors (N = 615) working in Clinical Trials Network (CTN) affiliated community treatment programs completed paper-and-pencil surveys. Implementation of the guidelines was inconsistent and selective. Counselors could be grouped into low versus high implementers. Some counselor characteristics differed based on their implementation cluster membership. [PUBLICATION ABSTRACT] JF - Journal of Psychoactive Drugs AU - Rothrauff, Tanja C, PhD AU - Eby, Lillian T, PhD Y1 - 2011 PY - 2011 DA - 2011 SP - 6 EP - 13 CY - Oxford PB - Haight Ashbury Publications VL - 43 IS - 1 SN - 02791072 KW - Pharmacy And Pharmacology KW - Smoking cessation KW - Substance abuse treatment KW - Counseling KW - Psychotropic drugs KW - Cluster analysis KW - United States KW - Factor Analysis, Statistical KW - United States Public Health Service KW - Motivation KW - Guideline Adherence KW - Humans KW - Principal Component Analysis KW - Adult KW - Treatment Outcome KW - Data Interpretation, Statistical KW - Guidelines as Topic KW - Smoking -- psychology KW - Cluster Analysis KW - Male KW - Female KW - Smoking Cessation -- methods KW - Counseling -- education KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1115556192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychoactive+Drugs&rft.atitle=Substance+Abuse+Counselors%27+Implementation+of+Tobacco+Cessation+Guidelines&rft.au=Rothrauff%2C+Tanja+C%2C+PhD%3BEby%2C+Lillian+T%2C+PhD&rft.aulast=Rothrauff&rft.aufirst=Tanja&rft.date=2011-03-01&rft.volume=43&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychoactive+Drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Taylor & Francis Ltd. 2011 N1 - Last updated - 2012-11-14 N1 - CODEN - JPDRD3 ER - TY - JOUR T1 - Survival of Plasmodium falciparum in human blood during refrigeration AN - 1028076604; 14521769 AB - BACKGROUND: Transfusion-transmitted malaria remains a serious concern for blood safety. Viable Plasmodium parasites must be present in human blood to transmit malaria, but their survival in blood over time stored under refrigeration has never been carefully investigated. STUDY DESIGN AND METHODS: We spiked leukoreduced normal human blood with Plasmodium falciparum (3D7 strain) asexual ring-stage parasites and stored it at 4 degree C for 28 days, taking samples at different days intervals. We evaluated the samples for parasitemia by blood film microscopy and by culturing red blood cells (RBCs) to allow further development of parasites. RESULTS: We observed a significant reduction in parasitemia (0.5% vs. 0.12%) after only 1 day in storage at 4 degree C. Thereafter, reduction in parasitemia was relatively gradual. Microscopically detectable parasites were present even after 28 days of storage. However, after storing for more than 14 days at 4 degree C, parasites no longer replicated when cultured in vitro. CONCLUSION: Although the storage of asexual blood-stage P. falciparum parasites at 4 degree C is detrimental to their survival (a 7.1-fold reduction in parasitemia after 14 days in storage), parasites remained microscopically detectable for 28 days, the end time point of our study. Further in vitro and in vivo studies will be needed to confirm loss of viability of P. falciparum after 14 days in storage, but our initial efforts repeatedly failed to show maturation and development of the parasites in cultured RBCs after that time. JF - Transfusion AU - Chattopadhyay, Rana AU - Majam, Victoria F AU - Kumar, Sanjai AD - From the Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, Maryland. Y1 - 2011/03// PY - 2011 DA - Mar 2011 SP - 630 EP - 635 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 3 SN - 0041-1132, 0041-1132 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Refrigeration KW - Parasites KW - Human diseases KW - Erythrocytes KW - Survival KW - Malaria KW - Plasmodium falciparum KW - Endoparasites KW - Public health KW - Blood KW - parasitemia KW - Microscopy KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028076604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Survival+of+Plasmodium+falciparum+in+human+blood+during+refrigeration&rft.au=Chattopadhyay%2C+Rana%3BMajam%2C+Victoria+F%3BKumar%2C+Sanjai&rft.aulast=Chattopadhyay&rft.aufirst=Rana&rft.date=2011-03-01&rft.volume=51&rft.issue=3&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02872.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Document feature - figure 1 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Refrigeration; Blood; Parasites; Human diseases; Erythrocytes; Survival; Malaria; Endoparasites; Public health; parasitemia; Microscopy; Plasmodium falciparum DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02872.x ER - TY - JOUR T1 - Calling the nation to act: Implementing the national action plan to improve health literacy AN - 1023092166; 201212741 AB - The National Action Plan to Improve Health Literacy is a framework that all clinical and public health professionals, including nurses, can use to identify and address health literacy barriers that negatively affect patient care and individual and community health outcomes. Of all the clinical disciplines, nursing has a unique relationship to health literacy because nurses are responsible for the majority of patient, caregiver and community health education, and communication. The information in the Action Plan is applicable to many fields and disciplines, such as healthcare, public health, communication, and education. Leading educators, researchers, practitioners, and administrators in each relevant discipline have a responsibility to be informed about health literacy issues and identify the most promising practices to improve health literacy in their domains. The Action Plan includes goals and strategies that nursing leaders can adapt and use to develop organization-specific action plans for health literacy improvement. The Action Plan is a call to action for all clinical professionals, especially nurses, to choose, implement, and evaluate one or more health literacy strategies so that patients will be more informed and prepared to protect, promote, and manage their health. [Copyright Elsevier B.V.] JF - Nursing Outlook AU - Baur, Cynthia AD - Centers for Disease Control and Prevention, U.S. Department of Health and Human Services Cynthia.baur@cdc.hhs.gov Y1 - 2011/03// PY - 2011 DA - March 2011 SP - 63 EP - 69 PB - Elsevier Ltd, The Netherlands VL - 59 IS - 2 SN - 0029-6554, 0029-6554 KW - Health literacy KW - National action plan to improve health literacy KW - Call to action KW - Health communication KW - Health information KW - Provider-patient communication KW - Clinical nursing KW - Community health KW - Nurse-Patient communication KW - Health education KW - Discipline KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023092166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Outlook&rft.atitle=Calling+the+nation+to+act%3A+Implementing+the+national+action+plan+to+improve+health+literacy&rft.au=Baur%2C+Cynthia&rft.aulast=Baur&rft.aufirst=Cynthia&rft.date=2011-03-01&rft.volume=59&rft.issue=2&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Nursing+Outlook&rft.issn=00296554&rft_id=info:doi/10.1016%2Fj.outlook.2010.12.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health education; Discipline; Public health; Clinical nursing; Nurse-Patient communication; Community health DO - http://dx.doi.org/10.1016/j.outlook.2010.12.003 ER - TY - JOUR T1 - Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers. AN - 848684939; 21163322 AB - Consumer and medical products can contain leachable chemical allergens which can cause skin sensitization. Recent efforts have been directed at the development of non-animal based tests such as in vitro cell activation assays for the identification of skin sensitizers. Prohapten identification by in vitro assays is still problematic due to the lack of prohapten bioactivation. The present study evaluated the effect of hapten and prohapten exposure on cell surface markers expression (CD86, CD54 and CD40) in the human monocytic leukemia, THP-1, cell line. Upregulation of activation and costimulatory markers are key events in the allergic sensitization process and have been reported to serve as indicators of skin sensitization. Cells were exposed to the prohaptens benzo(a)pyrene (BaP), 7,12-dimethylbenz(a)anthracene (DMBA), carvone oxime (COx), cinnamic alcohol (CA) and isoeugenol (IEG) at concentrations ranging from 1 to 10 μM for 24 and 48 h. The direct-binding haptens dinitrochlorobenzene (DNCB), benzoquinone (BQ), hydroxylethyl acrylate (HEA) and benzylbromide (BB) were used as positive controls. Cells were also exposed to the irritants sodium dodecyl sulfate (SDS) and sulfanilamide (SFA). Bioactivation of prohaptens was achieved by adding aroclor-induced rat liver microsomes (S9) to the cell cultures. Consistent upregulation of surface expressions of CD86, CD54 (ICAM-1) and CD40 was observed in THP-1 cells treated with direct-acting haptens (±S9) or prohapten (+S9). Upregulation of these markers was not observed after exposure to skin irritants or prohaptens in the absence of exogenously added S9. In conclusion, modification of in vitro cell culture assays to include co-incubation with microsomes enhances identification of prohaptens and allows them to be clearly distinguished from direct-binding haptens. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Chipinda, Itai AU - Ruwona, Tinashe B AU - Templeton, Steven P AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA. IChipinda@cdc.gov Y1 - 2011/02/27/ PY - 2011 DA - 2011 Feb 27 SP - 135 EP - 143 VL - 280 IS - 3 KW - Haptens KW - 0 KW - Propanols KW - Benzo(a)pyrene KW - 3417WMA06D KW - Eugenol KW - 3T8H1794QW KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - isoeugenol KW - 5M0MWY797U KW - cinnamyl alcohol KW - SS8YOP444F KW - Index Medicus KW - Rats KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Cell Line, Tumor KW - Eugenol -- toxicity KW - Microsomes, Liver -- metabolism KW - 9,10-Dimethyl-1,2-benzanthracene -- classification KW - Haptens -- classification KW - Eugenol -- metabolism KW - Benzo(a)pyrene -- classification KW - Haptens -- toxicity KW - Haptens -- metabolism KW - Propanols -- classification KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Eugenol -- classification KW - Propanols -- toxicity KW - Benzo(a)pyrene -- toxicity KW - Microsomes, Liver -- drug effects KW - Eugenol -- analogs & derivatives KW - Propanols -- metabolism KW - 9,10-Dimethyl-1,2-benzanthracene -- metabolism KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/848684939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Use+of+the+human+monocytic+leukemia+THP-1+cell+line+and+co-incubation+with+microsomes+to+identify+and+differentiate+hapten+and+prohapten+sensitizers.&rft.au=Chipinda%2C+Itai%3BRuwona%2C+Tinashe+B%3BTempleton%2C+Steven+P%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2011-02-27&rft.volume=280&rft.issue=3&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2010.12.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-07 N1 - Date created - 2011-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2010.12.004 ER - TY - JOUR T1 - Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine AN - 954592123; 14022931 AB - In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput and sensitive technique that has been used for illicit drug, explosive, volatile organic compound and chemical warfare detection. We evaluated a hand-held ion mobility spectrometer as a tool for the analysis of supplement extracts containing sibutramine. The overall instrumental limit of detection of five portable ion mobility spectrometers was 2 ng of sibutramine HCl. When sample extractions containing 30 ng/ mu l or greater of sibutramine were analyzed, saturation of the ionization chamber of the spectrometer occurred and the instrument required more than three cleaning cycles to remove the drug. Hence, supplement samples suspected of containing sibutramine should be prepared at concentrations of 2-20 ng/ mu l. To obtain this target concentration range for products containing unknown amounts of sibutramine, we provided a simple sample preparation procedure, allowing the U.S. Food and Drug Administration or other agencies to screen products using the portable ion mobility spectrometer. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Dunn, Jamie D AU - Gryniewicz-Ruzicka, Connie M AU - Kauffman, John F AU - Westenberger, Benjamin J AU - Buhse, Lucinda F AD - Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St., St. Louis, MO 63101, United States, Jamie.Dunn@fda.hhs.gov Y1 - 2011/02/20/ PY - 2011 DA - 2011 Feb 20 SP - 469 EP - 474 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 54 IS - 3 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Appetite suppressants KW - Dietary supplements KW - Explosives KW - Ionization KW - Mobility KW - Spectrometry KW - sibutramine KW - volatile organic compounds KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954592123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Using+a+portable+ion+mobility+spectrometer+to+screen+dietary+supplements+for+sibutramine&rft.au=Dunn%2C+Jamie+D%3BGryniewicz-Ruzicka%2C+Connie+M%3BKauffman%2C+John+F%3BWestenberger%2C+Benjamin+J%3BBuhse%2C+Lucinda+F&rft.aulast=Dunn&rft.aufirst=Jamie&rft.date=2011-02-20&rft.volume=54&rft.issue=3&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2010.09.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - sibutramine; Mobility; Dietary supplements; Appetite suppressants; volatile organic compounds; Explosives; Ionization; Spectrometry DO - http://dx.doi.org/10.1016/j.jpba.2010.09.017 ER - TY - CPAPER T1 - Laser Safety in Recent Biophotonics Technology and Medical Devices T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1313000051; 6045063 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Ilev, Ilko Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Lasers KW - medical equipment KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313000051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Laser+Safety+in+Recent+Biophotonics+Technology+and+Medical+Devices&rft.au=Ilev%2C+Ilko&rft.aulast=Ilev&rft.aufirst=Ilko&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Impact of Heparin Crisis on Public Standards and Regulatory Process T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312965325; 6045006 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Al-Hakim, Ali Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - crises KW - Heparin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312965325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=Impact+of+Heparin+Crisis+on+Public+Standards+and+Regulatory+Process&rft.au=Al-Hakim%2C+Ali&rft.aulast=Al-Hakim&rft.aufirst=Ali&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FDA's Approach to Science, Policy, and Research Needs for Nanotechnology T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312964217; 6045156 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Pena, Carlos Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - science policy KW - nanotechnology KW - FDA KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=FDA%27s+Approach+to+Science%2C+Policy%2C+and+Research+Needs+for+Nanotechnology&rft.au=Pena%2C+Carlos&rft.aulast=Pena&rft.aufirst=Carlos&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - View from Making Policy T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312923295; 6045390 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Robinson, Robin Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=View+from+Making+Policy&rft.au=Robinson%2C+Robin&rft.aulast=Robinson&rft.aufirst=Robin&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National Implementation of Research Integrity: Good Research Practice Education T2 - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AN - 1312905545; 6045428 JF - 2011 Annual Meeting of the American Association for the Advancement of Science (AAAS 2011) AU - Galland, John Y1 - 2011/02/17/ PY - 2011 DA - 2011 Feb 17 KW - Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.atitle=National+Implementation+of+Research+Integrity%3A+Good+Research+Practice+Education&rft.au=Galland%2C+John&rft.aulast=Galland&rft.aufirst=John&rft.date=2011-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://aaas.confex.com/aaas/2011/webprogram/start.html#srch=method|and|pge|1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Suppressive Effect of Bacterial Polysaccharides on BAFF System Is Responsible for Their Poor Immunogenicity AN - 907152418; 14341137 AB - Capsular polysaccharides of encapsulated bacteria are weakly immunogenic T cell-independent type 2 (TI-2) Ags. Recent findings suggest that BAFF system molecules have a critical role in the development of Ab responses against TI-2 Ags. In this study, we investigated the effect of bacterial polysaccharides on B cell responses to BAFF and a proliferation-inducing ligand (APRIL). We determined that B cells exposed to meningococcal type C polysaccharide (MCPS) or group B Streptococcus serotype V (GBS-V) were unresponsive to BAFF- and APRIL-induced Ig secretion. Moreover, MCPS and GBS-V strongly downregulated transmembrane activator and calcium-modulator and cyclophilin ligand interactor, the BAFF and APRIL receptor that is responsible for Ab development against TI-2 Ags. Interestingly, (4-hydroxy-3-nitrophenyl)acetyl-Ficoll (NP-Ficoll), a prototype TI-2 Ag, did not manifest a suppressive effect on B cells. Paradoxically, whereas GBS-V and MCPS inhibited IFN- gamma -induced BAFF production from dendritic cells, NP-Ficoll strongly increased BAFF secretion. TLR 9 agonist CpG deoxyoligonucleotide (ODN) was able to reverse the MCPS-mediated transmembrane activator and calcium-modulator and cyclophilin ligand interactor suppression but could not rescue the Ig secretion in BAFF- or APRIL-stimulated B cells. In support of these in vitro observations, it was observed that CpG ODN could help augment the Ab response against NP in mice immunized with a CpG ODN-containing NP-Ficoll vaccine but exhibited only marginal adjuvant activity for MCPS vaccine. Collectively, these results suggest a mechanism for the weak immunogenicity of bacterial polysaccharides and explain the previously observed differences between bacterial polysaccharide and NP-Ficoll immunogenicity. JF - Journal of Immunology AU - Kanswal, Sunita AU - Katsenelson, Nora AU - Allman, Windy AU - Uslu, Kadriye AU - Blake, Milan S AU - Akkoyunlu, Mustafa AD - Laboratory of Bacterial Polysaccharides, Division of Bacterial Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20852 Y1 - 2011/02/15/ PY - 2011 DA - 2011 Feb 15 SP - 2430 EP - 2443 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA VL - 186 IS - 4 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Streptococcus KW - Bacteria KW - gamma -Interferon KW - Serotypes KW - Lymphocytes B KW - APRIL protein KW - Neisseria meningitidis KW - CpG islands KW - Adjuvants KW - Antibody response KW - Oligonucleotides KW - Dendritic cells KW - Antibodies KW - Peptidylprolyl isomerase KW - Immunogenicity KW - Vaccines KW - Capsular polysaccharides KW - Immunoglobulins KW - BLyS protein KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907152418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Suppressive+Effect+of+Bacterial+Polysaccharides+on+BAFF+System+Is+Responsible+for+Their+Poor+Immunogenicity&rft.au=Kanswal%2C+Sunita%3BKatsenelson%2C+Nora%3BAllman%2C+Windy%3BUslu%2C+Kadriye%3BBlake%2C+Milan+S%3BAkkoyunlu%2C+Mustafa&rft.aulast=Kanswal&rft.aufirst=Sunita&rft.date=2011-02-15&rft.volume=186&rft.issue=4&rft.spage=2430&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Serotypes; Lymphocytes B; APRIL protein; Antibody response; Adjuvants; CpG islands; Oligonucleotides; Dendritic cells; Antibodies; Peptidylprolyl isomerase; Immunogenicity; Vaccines; Capsular polysaccharides; BLyS protein; Immunoglobulins; Streptococcus; Bacteria; Neisseria meningitidis ER - TY - JOUR T1 - Evaluation of surface plasmon resonance biosensors for detection of tetrodotoxin in food matrices and comparison to analytical methods. AN - 849432528; 21192708 AB - Tetrodotoxin (TTX) is a low molecular weight neurotoxin found in a number of animal species, including pufferfish. One emerging method for TTX detection employs surface plasmon resonance (SPR) immunosensors. SPR, an optical technique that allows for label-free, real-time, multiplexed analysis, can have detection limits that rival many of the conventional transduction methods. Preliminary SPR approaches for TTX were successful, yet suffered from low throughput and used noncommercial instrumentation. To advance this method for broader use, the immunoassay was transferred to a commercial instrument and optimized for improved detection. This manuscript outlines the assay development and results for complex matrices relevant to seafood safety (pufferfish) and food adulteration (milk, apple juice). In addition, results are compared to those obtained using receptor binding assay, ELISA, HPLC-FD, and LC/MS/MS detection techniques. Results highlight the advantages of SPR assays, including rapid screening capability with low reagent consumption and low- to subppb detection limits. JF - Journal of agricultural and food chemistry AU - Yakes, Betsy Jean AU - Deeds, Jonathan AU - White, Kevin AU - Degrasse, Stacey L AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA. betsy.yakes@fda.hhs.gov Y1 - 2011/02/09/ PY - 2011 DA - 2011 Feb 09 SP - 839 EP - 846 VL - 59 IS - 3 KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Immunoassay -- methods KW - Food Contamination -- analysis KW - Surface Plasmon Resonance -- methods KW - Food Analysis -- methods KW - Tetrodotoxin -- analysis KW - Seafood -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849432528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Evaluation+of+surface+plasmon+resonance+biosensors+for+detection+of+tetrodotoxin+in+food+matrices+and+comparison+to+analytical+methods.&rft.au=Yakes%2C+Betsy+Jean%3BDeeds%2C+Jonathan%3BWhite%2C+Kevin%3BDegrasse%2C+Stacey+L&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2011-02-09&rft.volume=59&rft.issue=3&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf103779k LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-19 N1 - Date created - 2011-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/jf103779k ER - TY - JOUR T1 - Human monoclonal antibodies to West Nile virus identify epitopes on the prM protein. AN - 822903803; 21084104 AB - Hybridoma cell lines (2E8, 8G8 and 5G12) producing fully human monoclonal antibodies (hMAbs) specific for the pre-membrane (prM) protein of West Nile virus (WNV) were prepared using a human fusion partner cell line, MFP-2, and human peripheral blood lymphocytes from a blood donor diagnosed with WNV fever in 2004. Using site-directed mutagenesis of a WNV-like particle (VLP) we identified 4 amino acid residues in the prM protein unique to WNV and important in the binding of these hMAbs to the VLP. Residues V19 and L33 are important epitopes for the binding of all three hMAbs. Mutations at residue, T20 and T24 affected the binding of hMAbs, 8G8 and 5G12 only. These hMAbs did not significantly protect AG129 interferon-deficient mice or Swiss Webster outbred mice from WNV infection. Published by Elsevier Inc. JF - Virology AU - Calvert, Amanda E AU - Kalantarov, Gavreel F AU - Chang, Gwong-Jen J AU - Trakht, Ilya AU - Blair, Carol D AU - Roehrig, John T AD - Arboviral Diseases Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 3150 Rampart Rd., Fort Collins, CO 80521, USA. zpz0@cdc.gov Y1 - 2011/02/05/ PY - 2011 DA - 2011 Feb 05 SP - 30 EP - 37 VL - 410 IS - 1 KW - Antibodies, Monoclonal KW - 0 KW - Epitopes KW - Viral Envelope Proteins KW - prM protein, Flavivirus KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Animals KW - Interferons -- genetics KW - Hybridomas KW - Interferons -- metabolism KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Cell Line KW - Protein Conformation KW - Mice, Knockout KW - Viral Envelope Proteins -- immunology KW - West Nile virus -- immunology KW - Antibodies, Monoclonal -- metabolism KW - West Nile virus -- metabolism KW - Epitopes -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822903803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Human+monoclonal+antibodies+to+West+Nile+virus+identify+epitopes+on+the+prM+protein.&rft.au=Calvert%2C+Amanda+E%3BKalantarov%2C+Gavreel+F%3BChang%2C+Gwong-Jen+J%3BTrakht%2C+Ilya%3BBlair%2C+Carol+D%3BRoehrig%2C+John+T&rft.aulast=Calvert&rft.aufirst=Amanda&rft.date=2011-02-05&rft.volume=410&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2010.10.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-17 N1 - Date created - 2011-01-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2010.10.033 ER - TY - JOUR T1 - A Signature of Maternal Anti-Fetal Rejection in Spontaneous Preterm Birth: Chronic Chorioamnionitis, Anti-Human Leukocyte Antigen Antibodies, and C4d AN - 907155743; 14389663 AB - Chronic chorioamnionitis is found in more than one-third of spontaneous preterm births. Chronic chorioamnionitis and villitis of unknown etiology represent maternal anti-fetal cellular rejection. Antibody-mediated rejection is another type of transplantation rejection. We investigated whether there was evidence for antibody-mediated rejection against the fetus in spontaneous preterm birth. This cross-sectional study included women with (1) normal pregnancy and term delivery (n=140) and (2) spontaneous preterm delivery (n=140). We analyzed maternal and fetal sera for panel-reactive anti-HLA class I and class II antibodies, and determined C4d deposition on umbilical vein endothelium by immunohistochemistry. Maternal anti-HLA class I seropositivity in spontaneous preterm births was higher than in normal term births (48.6% vs. 32.1%, p=0.005). Chronic chorioamnionitis was associated with a higher maternal anti-HLA class I seropositivity (p&0.01), significant in preterm and term birth. Villitis of unknown etiology was associated with increased maternal and fetal anti-HLA class I and II seropositivity (p&0.05, for each). Fetal anti-HLA seropositivity was closely related to maternal anti-HLA seropositivity in both groups (p&0.01, for each). C4d deposition on umbilical vein endothelium was more frequent in preterm labor than term labor (77.1% vs. 11.4%, p&0.001). Logistic regression analysis revealed that chronic chorioamnionitis (OR=6.10, 95% CI 1.29-28.83), maternal anti-HLA class I seropositivity (OR=5.90, 95% CI 1.60-21.83), and C4d deposition on umbilical vein endothelium (OR=36.19, 95% CI 11.42-114.66) were associated with preterm labor and delivery. A major subset of spontaneous preterm births has a signature of maternal anti-fetal cellular and antibody-mediated rejections with links to fetal graft-versus-host disease and alloimmune reactions. JF - PLoS ONE AU - Lee, JoonHo AU - Romero, Roberto AU - Xu, Yi AU - Kim, Jung-Sun AU - Topping, Vanessa AU - Yoo, Wonsuk AU - Kusanovic, Juan Pedro AU - Chaiworapongsa, Tinnakorn AU - Hassan, Sonia S AU - Yoon, Bo Hyun AU - Kim, Chong Jai AD - Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, United States of America Y1 - 2011/02/04/ PY - 2011 DA - 2011 Feb 04 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 6 IS - 2 KW - Toxicology Abstracts; Immunology Abstracts KW - Antibodies KW - Birth KW - Chorioamnionitis KW - Endothelium KW - Etiology KW - Fetuses KW - Graft rejection KW - Graft-versus-host reaction KW - Histocompatibility antigen HLA KW - Immunohistochemistry KW - Leukocytes KW - Pregnancy KW - Regression analysis KW - umbilical vein KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=A+Signature+of+Maternal+Anti-Fetal+Rejection+in+Spontaneous+Preterm+Birth%3A+Chronic+Chorioamnionitis%2C+Anti-Human+Leukocyte+Antigen+Antibodies%2C+and+C4d&rft.au=Lee%2C+JoonHo%3BRomero%2C+Roberto%3BXu%2C+Yi%3BKim%2C+Jung-Sun%3BTopping%2C+Vanessa%3BYoo%2C+Wonsuk%3BKusanovic%2C+Juan+Pedro%3BChaiworapongsa%2C+Tinnakorn%3BHassan%2C+Sonia+S%3BYoon%2C+Bo+Hyun%3BKim%2C+Chong+Jai&rft.aulast=Lee&rft.aufirst=JoonHo&rft.date=2011-02-04&rft.volume=6&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0016806 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-11-20 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Etiology; Graft rejection; Leukocytes; Graft-versus-host reaction; umbilical vein; Fetuses; Pregnancy; Birth; Antibodies; Endothelium; Regression analysis; Chorioamnionitis; Immunohistochemistry DO - http://dx.doi.org/10.1371/journal.pone.0016806 ER - TY - JOUR T1 - Dramatic Increases in Obesity and Overweight Prevalence and Body Mass Index Among Ethnic-Immigrant and Social Class Groups in the United States, 1976-2008 AN - 954595791; 14210836 AB - This study examined trends in US obesity and overweight prevalence and body mass index (BMI) among 30 immigrant groups, stratified by race/ethnicity and length of immigration, and among detailed education, occupation, and income/poverty groups from 1976 to 2008. Using 1976-2008 National Health Interview Surveys, differentials in obesity, overweight, and BMI, based on self-reported height and weight, were analyzed by using disparity indices, logistic, and linear regression. The obesity prevalence for the US population aged greater than or equal to 18 tripled from 8.7% in 1976 to 27.4% in 2008. Overweight prevalence increased from 36.9% in 1976 to 62.0% in 2008. During 1991-2008, obesity prevalence for US-born adults increased from 13.9 to 28.7%, while prevalence for immigrants increased from 9.5 to 20.7%. While immigrants in each ethnic group and time period had lower obesity and overweight prevalence and BMI than the US-born, immigrants' risk of obesity and overweight increased with increasing duration of residence. In 2003-2008, obesity prevalence ranged from 2.3% for recent Chinese immigrants to 31-39% for American Indians, US-born blacks, Mexicans, and Puerto Ricans, and long-term Mexican and Puerto Rican immigrants. Between 1976 and 2008, the obesity prevalence more than quadrupled for those with a college education or sales occupation. Although higher prevalence was observed for lower education, income, and occupation levels in each period, socioeconomic gradients in obesity and overweight decreased over time because of more rapid increases in prevalence among higher socioeconomic groups. Continued immigrant and socioeconomic disparities in prevalence will likely have substantial impacts on future obesity trends in the US. JF - Journal of Community Health AU - Singh, Gopal K AU - Siahpush, Mohammad AU - Hiatt, Robert A AU - Timsina, Lava R AD - US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 94 EP - 110 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 36 IS - 1 SN - 0094-5145, 0094-5145 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Body mass KW - obesity KW - Socioeconomics KW - body mass KW - poverty KW - income KW - Community health KW - Ethnic groups KW - Obesity KW - immigrants KW - Height KW - USA KW - Education KW - social class KW - Analysis KW - Interviews KW - Trends KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954595791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Dramatic+Increases+in+Obesity+and+Overweight+Prevalence+and+Body+Mass+Index+Among+Ethnic-Immigrant+and+Social+Class+Groups+in+the+United+States%2C+1976-2008&rft.au=Singh%2C+Gopal+K%3BSiahpush%2C+Mohammad%3BHiatt%2C+Robert+A%3BTimsina%2C+Lava+R&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2011-02-01&rft.volume=36&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-010-9287-9 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-07 N1 - SubjectsTermNotLitGenreText - Obesity; Education; Community health; Analysis; Body mass; Height; Interviews; Trends; Ethnic groups; social class; poverty; body mass; immigrants; income; obesity; Socioeconomics; USA DO - http://dx.doi.org/10.1007/s10900-010-9287-9 ER - TY - JOUR T1 - Predicting microstructure development during casting of drug-eluting coatings AN - 918070788; 16182273 AB - We have devised a novel diffuse interface formulation to model the development of chemical and physical inhomogeneities, i.e. microstructure, during the process of casting drug-eluting coatings. These inhomogeneities, which depend on the coating constituents and manufacturing conditions, can have a profound affect on the rate and extent of drug release, and therefore the ability of coated medical devices to function successfully. By deriving the model equations in a time-dependent reference frame, we find that it is computationally viable to probe a wide, physically relevant range of material and process quantities. To illustrate the application of the model, we have evaluated the impact of manufacturing solvent, coating thickness and evaporation rate on microstructure development. Our results suggest that modifying these process conditions can have a strong and nearly discontinuous effect on coating microstructure, and therefore on drug release. Further, we demonstrate that the model can be applied to processes that involve the incremental application of the coating in layers or passes. This new model formulation, which can also be used to predict the kinetics of drug release, provides a tool to elucidate and quantify the relationships between process variables, microstructure and performance. Establishing these relationships can reduce empiricism in materials selection and process design, providing a facile and efficient means to tailor the underlying microstructure and achieve a desired drug-release behavior. JF - Acta Biomaterialia AU - Saylor, David M AU - Guyer, Jonathan E AU - Wheeler, Daniel AU - Warren, James A AD - Division of Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA, david.saylor@fda.hhs.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 604 EP - 613 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 7 IS - 2 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Microstructure KW - Coating KW - Modeling KW - Simulation KW - Diffusion KW - Drug delivery KW - Mathematical models KW - Evaporation KW - Kinetics KW - Solvents KW - Probes KW - Drugs KW - Coatings KW - Models KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918070788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Predicting+microstructure+development+during+casting+of+drug-eluting+coatings&rft.au=Saylor%2C+David+M%3BGuyer%2C+Jonathan+E%3BWheeler%2C+Daniel%3BWarren%2C+James+A&rft.aulast=Saylor&rft.aufirst=David&rft.date=2011-02-01&rft.volume=7&rft.issue=2&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2010.09.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Drug delivery; Mathematical models; Evaporation; Kinetics; Probes; Solvents; Drugs; Models; Coatings DO - http://dx.doi.org/10.1016/j.actbio.2010.09.019 ER - TY - JOUR T1 - Reduction of Immunogenicity of Anthrax Vaccines Subjected to Thermal Stress, as Measured by a Toxin Neutralization Assay AN - 907155011; 14344859 AB - We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. JF - Clinical and Vaccine Immunology AU - Castelan-Vega, Juan AU - Corvette, Laura AU - Sirota, Lev AU - Arciniega, Juan AD - Center for Biologics Evaluation and Research, 1401 Rockville Pike, Rockville, Maryland 20852, Juan.Arciniega@fda.hhs.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 349 EP - 351 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 18 IS - 2 SN - 1556-679X, 1556-679X KW - Toxicology Abstracts; Immunology Abstracts KW - Anthrax KW - Immunogenicity KW - Stress KW - Temperature effects KW - Toxins KW - Vaccines KW - F 06905:Vaccines KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Reduction+of+Immunogenicity+of+Anthrax+Vaccines+Subjected+to+Thermal+Stress%2C+as+Measured+by+a+Toxin+Neutralization+Assay&rft.au=Castelan-Vega%2C+Juan%3BCorvette%2C+Laura%3BSirota%2C+Lev%3BArciniega%2C+Juan&rft.aulast=Castelan-Vega&rft.aufirst=Juan&rft.date=2011-02-01&rft.volume=18&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00267-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 10 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Immunogenicity; Stress; Anthrax; Vaccines; Toxins DO - http://dx.doi.org/10.1128/CVI.00267-10 ER - TY - JOUR T1 - Variation in Listeria monocytogenes Dose Responses in Relation to Subtypes Encoding a Full-Length or Truncated Internalin A AN - 907150836; 14344902 AB - Internalin A (InlA; encoded by inlA) facilitates the crossing of the intestinal barrier by Listeria monocytogenes. Mutations leading to a premature stop codon (PMSC) in inlA and thus attenuated mammalian virulence have been reported. We recently characterized 502 L. monocytogenes food isolates from a retail survey and 507 human clinical isolates from multiple U.S. states with respect to the presence/absence of inlA mutations. The objective of this study was to investigate the hypothesis that dose responses for human listeriosis vary between L. monocytogenes strains with and those without a PMSC in inlA. Subtype-specific prevalence and concentration distributions in food, along with epidemiologic and consumption data, were input into established dose-response models to generate an r value (probability of a cell causing illness). Under the conservative assumption that L. monocytogenes levels at retail represent levels consumed, mean log10 r values were -8.1 and -10.7 for L. monocytogenes subtypes with genes encoding a full-length and a truncated InlA, respectively. L. monocytogenes carrying a 5' frameshift mutation in a homopolymeric tract showed a mean log10 r value of -12.1. Confidence intervals for the r values and their differences varied depending on subtypes. When the increase in concentration of L. monocytogenes subtypes between retail and consumption was considered, mean log10 r values were reduced to -10.4, -13.8, and -12.8 for the subtypes with genes encoding a full-length InlA, for the subtypes carrying a PMSC in inlA, and for all L. monocytogenes isolates regardless of subtype, respectively. Our study provides further quantitative evidence that L. monocytogenes subtypes vary in abilities and relative likelihoods of causing human disease, which were mechanistically related to defined genetic markers. JF - Applied and Environmental Microbiology AU - Chen, Yuhuan AU - Ross, William H AU - Whiting, Richard C AU - Stelten, Anna Van AU - Nightingale, Kendra K AU - Wiedmann, Martin AU - Scott, Virginia N AD - Grocery Manufacturers Association, Washington, D.C, Yuhuan.Chen@fda.hhs.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 1171 EP - 1180 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 77 IS - 4 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Listeria monocytogenes KW - internalin KW - J:02450 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907150836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Variation+in+Listeria+monocytogenes+Dose+Responses+in+Relation+to+Subtypes+Encoding+a+Full-Length+or+Truncated+Internalin+A&rft.au=Chen%2C+Yuhuan%3BRoss%2C+William+H%3BWhiting%2C+Richard+C%3BStelten%2C+Anna+Van%3BNightingale%2C+Kendra+K%3BWiedmann%2C+Martin%3BScott%2C+Virginia+N&rft.aulast=Chen&rft.aufirst=Yuhuan&rft.date=2011-02-01&rft.volume=77&rft.issue=4&rft.spage=1171&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01564-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - internalin; Listeria monocytogenes DO - http://dx.doi.org/10.1128/AEM.01564-10 ER - TY - JOUR T1 - An Investigation of Microbial Contamination of Ready-to-Eat Products in Seoul, Korea AN - 904474044; 14542300 AB - This study was carried out to examine microbiological contamination of ready-to-eat products and to propose a draft-standard and specifications according to food types. RTE foods were classified into 6 groups including fish products, meat products, breads, rices, salads, and fresh cut foods. The prevalence rates of pathogens detected from all samples were compared among food categories. The pH ranges for all RTE samples were between 3.8 and 7.3. Total aerobic cell counts ranged from 2 to 6 log CFU/g. Bread, rice and fresh-cut foods showed significantly higher counts, which ranged above 4.0 log CFU/g among the samples. Two kinds of rice were above the level of the KFDA Food Code standard for Eschrichia coli. The prevalence rate of E. coli in the rice was 6.7%. For Staphylococcus aureus, one fish product and one bread-product had levels above 2 log CFU/g. Bacillus cereus counts for all samples were below the level of 3 log CFU/g. Listeria monocytogenes was not detected in the samples. Therefore, these data suggest that the primary microbial hazard factors for ready-to-eat foods and risk assessments should focus on E. coli, S. aureus, and B. cereus. JF - Korean Journal of Food Science and Technology AU - Kim, H-Y AU - Oh, S-W AU - Chung, S-Y AU - Choi, S-H AU - Lee, J-W AU - Yang, J-Y AU - Seo, E-C AU - Kim, Y-H AU - Park, H-O AU - Yang, C-Y AU - Ha, S-C AU - Shin, I-S AD - Hazard Substances Analysis Division, Seoul Regional Korea Food and Drug Administration, Seoul 158-050, Korea, ohsw0507@korea.kr Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 39 EP - 44 PB - Korean Society of Food Science and Technology, The Korea Science and Technology Center #605 635-4 Yeogsam-dong, Kangnam-ku Seoul 135-703 Korea, Republic of VL - 43 IS - 1 SN - 0367-6293, 0367-6293 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Meat products KW - Risk assessment KW - Listeria monocytogenes KW - Bread KW - Data processing KW - Food KW - Bacillus cereus KW - Oryza sativa KW - Pathogens KW - Food contamination KW - Colony-forming cells KW - Escherichia coli KW - Staphylococcus aureus KW - pH effects KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904474044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=An+Investigation+of+Microbial+Contamination+of+Ready-to-Eat+Products+in+Seoul%2C+Korea&rft.au=Kim%2C+H-Y%3BOh%2C+S-W%3BChung%2C+S-Y%3BChoi%2C+S-H%3BLee%2C+J-W%3BYang%2C+J-Y%3BSeo%2C+E-C%3BKim%2C+Y-H%3BPark%2C+H-O%3BYang%2C+C-Y%3BHa%2C+S-C%3BShin%2C+I-S&rft.aulast=Kim&rft.aufirst=H-Y&rft.date=2011-02-01&rft.volume=43&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Meat products; Bread; Data processing; Colony-forming cells; Food; Pathogens; Food contamination; pH effects; Listeria monocytogenes; Escherichia coli; Oryza sativa; Bacillus cereus; Staphylococcus aureus ER - TY - JOUR T1 - Reflections on the need for continued research on writing AN - 902094588; 201111875 AB - A focused scientific research effort on writing research and its relationship to language development and reading is needed to address the writing and broader literacy needs of today's and tomorrow's learners and workers. In the United States, as well as in many other nations, research on writing has been neglected in relation to the emphasis on reading and oral language more generally. The authors argue first for why there is a need for this refocused effort, what should be focused on, and how as a field we should consider moving forward and addressing this imperative. In addressing the why, the authors argue that need is not limited to a particular age or developmental range but rather is broad-based, beginning with our youngest learners and continuing through those transitioning into post-secondary and the workplace. The clear message is that the picture is surprisingly similar across age ranges with a demonstrated need beginning with those coming from less advantaged backgrounds into formal education to the majority of students transitioning from twelfth grade into the workplace or post secondary settings. The authors suggest next steps for research addressing both what and how: what areas of science are areas of high need and how the field may consider moving forward to address these needs. Interdisciplinary research on writing is needed that addresses and integrates cognitive, biological, and social-cultural traditions, contributions, and methods. Adapted from the source document JF - Reading and Writing AU - Miller, Brett AU - McCardle, Peggy AD - US Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd., Bethesda, MD millerbre@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 121 EP - 132 VL - 24 IS - 2 SN - 0922-4777, 0922-4777 KW - Education (20900) KW - Writing (98550) KW - Reading Writing Relationship (71650) KW - Research Design (72950) KW - article KW - 4712: theory of linguistics; research design, methodology, and tools KW - 4121: applied linguistics; writing: instruction, acquisition, processes, and testing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902094588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+and+Writing&rft.atitle=Reflections+on+the+need+for+continued+research+on+writing&rft.au=Miller%2C+Brett%3BMcCardle%2C+Peggy&rft.aulast=Miller&rft.aufirst=Brett&rft.date=2011-02-01&rft.volume=24&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Reading+and+Writing&rft.issn=09224777&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - REWRE8 N1 - SubjectsTermNotLitGenreText - Writing (98550); Reading Writing Relationship (71650); Education (20900); Research Design (72950) ER - TY - JOUR T1 - Internal Consistency, Retest Reliability, and Their Implications for Personality Scale Validity AN - 902084273; 201122168 AB - The authors examined data (N = 34,108) on the differential reliability and validity of facet scales from the NEO Inventories. They evaluated the extent to which (a) psychometric properties of facet scales are generalizable across ages, cultures, and methods of measurement, and, (b) validity criteria are associated with different forms of reliability. Composite estimates of facet scale stability, heritability, and cross-observer validity were broadly generalizable. Two estimates of retest reliability were independent predictors of the three validity criteria; none of three estimates of internal consistency was. Available evidence suggests the same pattern of results for other personality inventories. Internal consistency of scales can be useful as a check on data quality but appears to be of limited utility for evaluating the potential validity of developed scales, and it should not be used as a substitute for retest reliability. Further research on the nature and determinants of retest reliability is needed. Adapted from the source document. JF - Personality and Social Psychology Review AU - McCrae, Robert R AU - Kurtz, John E AU - Yamagata, Shinji AU - Terracciano, Antonio AD - National Institute on Aging, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, MD Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 28 EP - 50 PB - Sage Publications, Thousand Oaks CA VL - 15 IS - 1 SN - 1088-8683, 1088-8683 KW - reliability validity cross-national five-factor model personality traits KW - Validity KW - Personality KW - Data Quality KW - article KW - 0312: social psychology; personality & social roles (individual traits, social identity, adjustment, conformism, & deviance) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902084273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Social+Psychology+Review&rft.atitle=Internal+Consistency%2C+Retest+Reliability%2C+and+Their+Implications+for+Personality+Scale+Validity&rft.au=McCrae%2C+Robert+R%3BKurtz%2C+John+E%3BYamagata%2C+Shinji%3BTerracciano%2C+Antonio&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2011-02-01&rft.volume=15&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Personality+and+Social+Psychology+Review&rft.issn=10888683&rft_id=info:doi/10.1177%2F1088868310366253 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - PSPRFG N1 - SubjectsTermNotLitGenreText - Personality; Validity; Data Quality DO - http://dx.doi.org/10.1177/1088868310366253 ER - TY - JOUR T1 - Comparison of Two Platelet Activation Markers Using Flow Cytometry After In Vitro Shear Stress Exposure of Whole Human Blood AN - 879477018; 14397917 AB - Platelet activation is the initiating step to thromboembolic complications in blood-contacting medical devices. Currently, there are no widely accepted testing protocols or relevant metrics to assess platelet activation during the in vitro evaluation of new medical devices. In this article, two commonly used platelet activation marker antibodies, CD62P (platelet surface P-selectin) and PAC1 (activated GP IIb/IIIa), were evaluated using flow cytometry. Anticoagulant citrate dextrose solution A (ACDA) and heparin anticoagulated human blood from healthy donors were separately exposed to shear stresses of 0, 10, 15, and 20Pa for 120s using a cone-plate rheometer model, and immediately mixed with the platelet marker antibodies for analysis. To monitor for changes in platelet reactivity between donors and over time, blood samples were also evaluated after exposure to 0, 2, and 20 mu M of adenosine diphosphate (ADP). Following ADP stimulation, the percentage of both CD62P and PAC1 positive platelets increased in a dose dependent fashion, even 8h after the blood was collected. After shear stress stimulation, both CD62P and PAC1 positive platelets increased significantly at shear stress levels of 15 and 20Pa when ACDA was used as the anticoagulant. However, for heparinized blood, the PAC1 positive platelets decreased with increasing shear stress, while the CD62P positive platelets increased. Besides the anticoagulant effect, the platelet staining buffer also impacted PAC1 response, but had little effect on CD62P positive platelets. These data suggest that CD62P is a more reliable marker compared with PAC1 for measuring shear-dependent platelet activation and it has the potential for use during in vitro medical device testing. JF - Artificial Organs AU - Lu, Qijin AU - Malinauskas, Richard A AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 137 EP - 144 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 35 IS - 2 SN - 0160-564X, 0160-564X KW - Health & Safety Science Abstracts; Biotechnology and Bioengineering Abstracts KW - ADP KW - medical equipment KW - Platelets KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/879477018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Organs&rft.atitle=Comparison+of+Two+Platelet+Activation+Markers+Using+Flow+Cytometry+After+In+Vitro+Shear+Stress+Exposure+of+Whole+Human+Blood&rft.au=Lu%2C+Qijin%3BMalinauskas%2C+Richard+A&rft.aulast=Lu&rft.aufirst=Qijin&rft.date=2011-02-01&rft.volume=35&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Artificial+Organs&rft.issn=0160564X&rft_id=info:doi/10.1111%2Fj.1525-1594.2010.01051.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Document feature - figure 3 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Platelets; medical equipment DO - http://dx.doi.org/10.1111/j.1525-1594.2010.01051.x ER - TY - JOUR T1 - Data Watch: Seniors' Perceptions Of Health Care Not Closely Associated With Physician Supply AN - 875716992; 201116010 AB - We conducted a national random survey of Medicare beneficiaries to better understand the association between the supply of physicians and patients' perceptions of their health care. We found that patients living in areas with more physicians per capita had perceptions of their health care that were similar to those of patients in regions with fewer physicians. In addition, there were no significant differences between the groups of patients in terms of numbers of visits to their personal physician in the previous year; amount of time spent with a physician; or access to tests or specialists. Our results suggest that simply training more physicians is unlikely to lead to improved access to care. Instead, focusing health policy on improving the quality and organization of care may be more beneficial. Adapted from the source document. JF - Health Affairs AU - Nyweide, David J AU - Anthony, Denise L AU - Chang, Chiang-Hua AU - Goodman, David AD - Social science research analyst, Office of Research, Development, and Information, Centers for Medicare and Medicaid Services, in Baltimore, Maryland E-mail: david.nyweide@cms.hhs.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 219 EP - 227 PB - Project HOPE, Bethesda MD VL - 30 IS - 2 SN - 0278-2715, 0278-2715 KW - Training KW - Quality of Health Care KW - Specialists KW - Access KW - Physicians KW - Patients KW - Health Policy KW - Health Care Services KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/875716992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Data+Watch%3A+Seniors%27+Perceptions+Of+Health+Care+Not+Closely+Associated+With+Physician+Supply&rft.au=Nyweide%2C+David+J%3BAnthony%2C+Denise+L%3BChang%2C+Chiang-Hua%3BGoodman%2C+David&rft.aulast=Nyweide&rft.aufirst=David&rft.date=2011-02-01&rft.volume=30&rft.issue=2&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0602 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-07-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Patients; Physicians; Health Care Services; Quality of Health Care; Specialists; Health Policy; Training; Access DO - http://dx.doi.org/10.1377/hlthaff.2010.0602 ER - TY - JOUR T1 - Invited Review: Nanotoxicology-A Pathologist's Perspective AN - 874181757; 14813475 AB - Advances in chemistry and engineering have created a new technology, nanotechnology, involving the tiniest known manufactured products. These products have a rapidly increasing market share and appear poised to revolutionize engineering, cosmetics, and medicine. Unfortunately, nanotoxicology, the study of nanoparticulate health effects, lags behind advances in nanotechnology. Over the past decade, existing literature on ultrafine particles and respirable durable fibers has been supplemented by studies of first-generation nanotechnology products. These studies suggest that nanosizing increases the toxicity of many particulates. First, as size decreases, surface area increases, thereby speeding up dissolution of soluble particulates and exposing more of the reactive surface of durable but reactive particulates. Second, nanosizing facilitates movement of particulates across cellular and intracellular barriers. Third, nanosizing allows particulates to interact with, and sometimes even hybridize with, subcellular structures, including in some cases microtubules and DNA. Finally, nanosizing of some particulates, increases pathologic and physiologic responses, including inflammation, fibrosis, allergic responses, genotoxicity, and carcinogenicity, and may alter cardiovascular and lymphatic function. Knowing how the size and physiochemical properties of nanoparticulates affect bioactivity is important in assuring that the exciting new products of nanotechnology are used safely. This review provides an introduction to the pathology and toxicology of nanoparticulates. JF - Toxicologic Pathology AU - Hubbs, Ann F AU - Mercer, Robert R AU - Benkovic, Stanley A AU - Harkema, Jack AU - Sriram, Krishnan AU - Schwegler-Berry, Diane AU - Goravanahally, Madhusudan P AU - Nurkiewicz, Timothy R AU - Castranova, Vincent AU - Sargent, Linda M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA, ahubbs@cdc.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 301 EP - 324 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 2 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Microtubules KW - Fibrosis KW - Surface area KW - Genotoxicity KW - Cosmetics KW - Inflammation KW - Fibers KW - Hypersensitivity KW - Carcinogenicity KW - DNA KW - Dissolution KW - nanoparticles KW - nanotechnology KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874181757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Invited+Review%3A+Nanotoxicology-A+Pathologist%27s+Perspective&rft.au=Hubbs%2C+Ann+F%3BMercer%2C+Robert+R%3BBenkovic%2C+Stanley+A%3BHarkema%2C+Jack%3BSriram%2C+Krishnan%3BSchwegler-Berry%2C+Diane%3BGoravanahally%2C+Madhusudan+P%3BNurkiewicz%2C+Timothy+R%3BCastranova%2C+Vincent%3BSargent%2C+Linda+M&rft.aulast=Hubbs&rft.aufirst=Ann&rft.date=2011-02-01&rft.volume=39&rft.issue=2&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623310390705 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Number of references - 244 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Microtubules; Fibrosis; Surface area; Genotoxicity; Cosmetics; Inflammation; Fibers; Hypersensitivity; Carcinogenicity; DNA; Dissolution; nanoparticles; nanotechnology DO - http://dx.doi.org/10.1177/0192623310390705 ER - TY - JOUR T1 - Product Biomonitoring and Responsible Reporting AN - 869799184; 14444562 AB - Abstract not available. JF - Environmental Health Perspectives AU - Jung, Paul AD - Chief of Staff, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, jungp@niehs.nih.gov Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - A58 EP - A59 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 2 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Bioindicators KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869799184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Product+Biomonitoring+and+Responsible+Reporting&rft.au=Jung%2C+Paul&rft.aulast=Jung&rft.aufirst=Paul&rft.date=2011-02-01&rft.volume=119&rft.issue=2&rft.spage=A58&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1003355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Bioindicators DO - http://dx.doi.org/10.1289/ehp.1003355 ER - TY - RPRT T1 - Understanding Parents' Child Care Decision-Making: A Foundation for Child Care Policy Making. Research-to-Policy, Research-to-Practice Brief. OPRE 2011-12 AN - 864941463; ED517546 AB - Policies such as those related to child care subsidies and quality rating and improvement systems are designed to increase the likelihood that child care and education arrangements meet developmental needs of children and employment needs of parents. Ultimately, parents select child care arrangements, and the quality and stability of these arrangements are affected by parents' decisions. The decisions parents make regarding child care affect the ability of child care policies to achieve desired outcomes. How well policies "fit" into and support the complex parental child care decision-making process affects achievement of policy goals. Child care is one component of a complex set of family management decisions that are often made simultaneously. For example, parents commonly make child care, employment, and transportation decisions at the same time. Parents attempt to find a child care solution that meets both child development and employment goals. Parents work to find the solution which best fits their situation, but the resulting child care arrangement(s) may or may not meet all their goals. Child care and early education decision-making cannot be understood outside of the world in which a family lives and works, and understanding this context is key to creating child care and early education policies that support parental decision-making. Using a graphic representation of the decision-making process, this paper provides insights into the forces that shape parents' child care and early education decisions. The goal of this brief is to help policy makers by graphically depicting the complexity of child care decision-making revealed through research. AU - Weber, Roberta Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 12 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Policymakers KW - Preschool Education KW - Context Effect KW - Parent Responsibility KW - Parent Child Relationship KW - Employed Parents KW - Resource Allocation KW - Parent Attitudes KW - Child Care KW - Public Policy KW - Decision Making KW - Time Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941463?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - ASSESSMENT OF MICROBIAL CONTAMINATION LEVELS OF STREET-VENDED FOODS IN KOREA AN - 864401162; 14375692 AB - This study was conducted to evaluate the microbial quality of street-vended foods in Korea. The microbiological contamination levels of aerobic mesophilic bacteria ranged from 0 to 7.43logcfu/g with a mean value of 4.71+/-1.53logcfu/g, while the level of total coliforms ranged from 0 to 6.86logcfu/g with a mean value of 3.24+/-1.40logcfu/g. Staphylococcus aureus (SA) and Escherichia coli (EC) were detected in 9% (mean value: 3.75+/-0.56logcfu/g) and 3% (mean value: 2.33+/-0.90logcfu/g) of 326 examined samples, respectively. Vibrio parahaemolyticus, Salmonella spp. and Listeria monocytogenes were not detected. More than 50% of the isolated SA were found to be enterotoxin producers and these organisms primarily possessed type A toxin genes. Conversely, verocytotoxin-producing EC were not detected. Taken together, these results indicate that consumption of street-vended foods may pose a risk of foodborne disease and that good hygienic practices should be required to ensure public health. Accurate and up-to-date data for microbiological contamination of ready-to-eat foods are necessary for consumer protection to improve sanitary conditions in food processing plants in Korea. Known contamination levels can be used by administrators to establish national regulations for the control of foodborne diseases. JF - Journal of Food Safety AU - Cho, Joon-Il AU - Cheung, Chi-Yeun AU - Lee, Sun-Mi AU - Ko, Soo-Il AU - Kim, Kyu-Heon AU - Hwang, In-sun AU - Kim, Seung-Hwan AU - Cho, Soo-Yeol AU - Lim, Chul-Ju AU - Lee, Kwang-Ho AU - Kim, Keun-Sung AU - Ha, Sang-Do AD - Testing and Analysis Division, Gyeongin Regional Food and Drug Administration, Nam-Gu, Incheon, Korea Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 41 EP - 47 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 31 IS - 1 SN - 0149-6085, 0149-6085 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Risk Abstracts; Health & Safety Science Abstracts KW - Food processing KW - Mesophilic bacteria KW - Food KW - Microbial contamination KW - food-borne diseases KW - Public health KW - Food consumption KW - Sanitation KW - Vibrio parahaemolyticus KW - Escherichia coli KW - Consumers KW - Korea, Rep. KW - Staphylococcus aureus KW - Food quality KW - Listeria monocytogenes KW - Coliforms KW - Data processing KW - Food plants KW - Food contamination KW - Toxins KW - consumer protection KW - Enterotoxins KW - Hygiene KW - Salmonella KW - A 01330:Food Microbiology KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864401162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Safety&rft.atitle=ASSESSMENT+OF+MICROBIAL+CONTAMINATION+LEVELS+OF+STREET-VENDED+FOODS+IN+KOREA&rft.au=Cho%2C+Joon-Il%3BCheung%2C+Chi-Yeun%3BLee%2C+Sun-Mi%3BKo%2C+Soo-Il%3BKim%2C+Kyu-Heon%3BHwang%2C+In-sun%3BKim%2C+Seung-Hwan%3BCho%2C+Soo-Yeol%3BLim%2C+Chul-Ju%3BLee%2C+Kwang-Ho%3BKim%2C+Keun-Sung%3BHa%2C+Sang-Do&rft.aulast=Cho&rft.aufirst=Joon-Il&rft.date=2011-02-01&rft.volume=31&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Safety&rft.issn=01496085&rft_id=info:doi/10.1111%2Fj.1745-4565.2010.00264.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Document feature - figure 0 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Food processing; Mesophilic bacteria; Coliforms; Data processing; Food; Food contamination; Food plants; Toxins; Public health; Food consumption; Enterotoxins; Consumers; Food quality; Hygiene; Sanitation; consumer protection; Microbial contamination; food-borne diseases; Listeria monocytogenes; Vibrio parahaemolyticus; Escherichia coli; Staphylococcus aureus; Salmonella; Korea, Rep. DO - http://dx.doi.org/10.1111/j.1745-4565.2010.00264.x ER - TY - JOUR T1 - A Survey of Indian Health Service and Tribal Health Providers' Colorectal Cancer Screening Knowledge, Perceptions, and Practices AN - 862591266; 201109684 AB - Background. Provider recommendation is critical for colorectal cancer (CRC) screening participation, yet few data exist on practices of providers serving American Indians and Alaska Natives. We examined Indian Health Service (IHS) and tribal provider practices, beliefs about screening efficacy, and perceptions of barriers. Methods. We developed a Web-based questionnaire and recruited respondents via electronic distribution lists. We generated descriptive statistics by region, provider type, and workplace setting. Results. Most respondents (77%) recommend starting CRC screening of average-risk patients at age 50; however, 22% recommend flexible sigmoidoscopy and 43% colonoscopy at intervals inconsistent with national guidelines. Of those recommending fecal occult blood test (FOBT), 23% use a single, in-office FOBT card as their only FOBT method. Respondents reported barriers to screening to include underutilized reminder systems and inadequate resources. Conclusions. Indian Health Service/tribal providers are knowledgeable about when to begin CRC screening; however, education about the appropriate use and frequency of CRC tests is needed. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Haverkamp, Donald AU - Perdue, David G AU - Espey, David AU - Cobb, Nathaniel Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 243 EP - 257 PB - John Hopkins University Press, Baltimore MD VL - 22 IS - 1 SN - 1049-2089, 1049-2089 KW - American Indians and Alaska Natives, colorectal cancer, screening, providers KW - Screening KW - Sigmoidoscopy KW - Perceptions KW - Computer based KW - Colorectal cancer KW - Health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862591266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=A+Survey+of+Indian+Health+Service+and+Tribal+Health+Providers%27+Colorectal+Cancer+Screening+Knowledge%2C+Perceptions%2C+and+Practices&rft.au=Haverkamp%2C+Donald%3BPerdue%2C+David+G%3BEspey%2C+David%3BCobb%2C+Nathaniel&rft.aulast=Haverkamp&rft.aufirst=Donald&rft.date=2011-02-01&rft.volume=22&rft.issue=1&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Screening; Colorectal cancer; Health services; Perceptions; Sigmoidoscopy; Computer based ER - TY - JOUR T1 - Toward an automatic method for extracting cancer- and other disease-related point mutations from the biomedical literature AN - 861561625; 14310407 AB - Motivation: A major goal of biomedical research in personalized medicine is to find relationships between mutations and their corresponding disease phenotypes. However, most of the disease-related mutational data are currently buried in the biomedical literature in textual form and lack the necessary structure to allow easy retrieval and visualization. We introduce a high-throughput computational method for the identification of relevant disease mutations in PubMed abstracts applied to prostate (PCa) and breast cancer (BCa) mutations.Results: We developed the extractor of mutations (EMU) tool to identify mutations and their associated genes. We benchmarked EMU against MutationFinder--a tool to extract point mutations from text. Our results show that both methods achieve comparable performance on two manually curated datasets. We also benchmarked EMU's performance for extracting the complete mutational information and phenotype. Remarkably, we show that one of the steps in our approach, a filter based on sequence analysis, increases the precision for that task from 0.34 to 0.59 (PCa) and from 0.39 to 0.61 (BCa). We also show that this high-throughput approach can be extended to other diseases.Discussion: Our method improves the current status of disease-mutation databases by significantly increasing the number of annotated mutations. We found 51 and 128 mutations manually verified to be related to PCa and Bca, respectively, that are not currently annotated for these cancer types in the OMIM or Swiss-Prot databases. EMU's retrieval performance represents a 2-fold improvement in the number of annotated mutations for PCa and BCa. We further show that our method can benefit from full-text analysis once there is an increase in Open Access availability of full-text articles.Availability: Freely available at: http://bioinf.umbc.edu/EMU/ftp.Contact: mkann super(m)bc.eduSupplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Doughty, Emily AU - Kertesz-Farkas, Attila AU - Bodenreider, Olivier AU - Thompson, Gary AU - Adadey, Asa AU - Peterson, Thomas AU - Kann, Maricel G AD - super(1)University of Maryland, Baltimore County, Baltimore, MD 21250, super(2)Division of Imaging and Applied Mathematics, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993 and super(3)National Library of Medicine, Bethesda, MD 20894, USA Y1 - 2011/02/01/ PY - 2011 DA - 2011 Feb 01 SP - 408 EP - 415 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 27 IS - 3 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Data processing KW - Point mutation KW - Breast cancer KW - Bioinformatics KW - Computer applications KW - Prostate KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/861561625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Toward+an+automatic+method+for+extracting+cancer-+and+other+disease-related+point+mutations+from+the+biomedical+literature&rft.au=Doughty%2C+Emily%3BKertesz-Farkas%2C+Attila%3BBodenreider%2C+Olivier%3BThompson%2C+Gary%3BAdadey%2C+Asa%3BPeterson%2C+Thomas%3BKann%2C+Maricel+G&rft.aulast=Doughty&rft.aufirst=Emily&rft.date=2011-02-01&rft.volume=27&rft.issue=3&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtq667 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Data processing; Point mutation; Breast cancer; Bioinformatics; Computer applications; Prostate; Internet DO - http://dx.doi.org/10.1093/bioinformatics/btq667 ER - TY - JOUR T1 - MicroPET imaging of ketamine-induced neuronal apoptosis with radiolabeled DFNSH. AN - 856407327; 20963452 AB - Recent reports indicate that 6-12 h of ketamine anesthesia can trigger neuronal apoptosis in postnatal day (PND) 7 rats. In vitro, ex vivo, and confocal fluorescent imaging studies suggest that dansyl compounds can accumulate within the cytoplasm of the apoptotic cell. High-resolution positron emission tomography (microPET) imaging has been proposed as a minimally invasive method for detecting apoptosis in the rat brain. Compared with [(18)F]-labeled annexin V, which binds to externalized phosphatidylserine (PS) on the outer membrane of apoptotic cells, intracellular uptake of the dansylhydrazone of p-fluorobenzaldehyde (DFNSH) may lead to improved target-to-background contrast ratios. In this study, the effect of ketamine on the uptake and retention of [(18)F]-DFNSH in the rat brain was investigated using microPET imaging. On PND 7, rat pups in the experimental group were exposed, at 2-h intervals, to six subcutaneous injections of ketamine (20 mg/kg) and control rat pups received six injections of saline. On PND 35, [(18)F]-DFNSH (37 MBq) was injected into the tail vein of rats and microPET images were obtained over 2 h following the injection. Radiolabeled tracer accumulation in the region of interest (ROI) in the frontal cortex was converted into standard uptake values (SUVs). The radiotracer was quickly distributed into the brains of both ketamine- and saline-treated rats. Compared with the control group, the uptake of [(18)F]-DFNSH was significantly increased in the ROI, frontal cortex area of ketamine-treated rats. In addition, the wash-out duration of the tracer was prolonged in the ketamine-treated animals. This study demonstrates that microPET imaging is capable of distinguishing differences in retention of [(18)F]-DFNSH in ROI and suggests that this compound may serve as a minimally invasive biomarker of neuronal apoptosis in rodents. JF - Journal of neural transmission (Vienna, Austria : 1996) AU - Zhang, X AU - Paule, M G AU - Newport, G D AU - Sadovova, N AU - Berridge, M S AU - Apana, S M AU - Kabalka, G AU - Miao, W AU - Slikker, W AU - Wang, Cheng AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 203 EP - 211 VL - 118 IS - 2 KW - Anesthetics, Dissociative KW - 0 KW - Benzaldehydes KW - Fluorine Radioisotopes KW - Radiopharmaceuticals KW - Ketamine KW - 690G0D6V8H KW - Index Medicus KW - Rats KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Rats, Sprague-Dawley KW - Fluorine Radioisotopes -- pharmacokinetics KW - Apoptosis -- drug effects KW - Enzyme-Linked Immunosorbent Assay KW - Tissue Distribution KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Benzaldehydes -- pharmacokinetics KW - Ketamine -- toxicity KW - Positron-Emission Tomography -- methods KW - Neurons -- drug effects KW - Brain -- drug effects KW - Brain -- metabolism KW - Anesthetics, Dissociative -- toxicity KW - Brain -- diagnostic imaging KW - Neurons -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856407327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neural+transmission+%28Vienna%2C+Austria+%3A+1996%29&rft.atitle=MicroPET+imaging+of+ketamine-induced+neuronal+apoptosis+with+radiolabeled+DFNSH.&rft.au=Zhang%2C+X%3BPaule%2C+M+G%3BNewport%2C+G+D%3BSadovova%2C+N%3BBerridge%2C+M+S%3BApana%2C+S+M%3BKabalka%2C+G%3BMiao%2C+W%3BSlikker%2C+W%3BWang%2C+Cheng&rft.aulast=Zhang&rft.aufirst=X&rft.date=2011-02-01&rft.volume=118&rft.issue=2&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+neural+transmission+%28Vienna%2C+Austria+%3A+1996%29&rft.issn=1435-1463&rft_id=info:doi/10.1007%2Fs00702-010-0499-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-12 N1 - Date created - 2011-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00702-010-0499-z ER - TY - JOUR T1 - Factors Associated With Taiwanese Junior High School Personnel Advising Students to Quit Smoking AN - 855898969; 201106919 AB - BACKGROUND: Most smokers in developing countries begin smoking before age 18, and smoking prevalence is rising among adolescents. School personnel represent a target group for tobacco-control efforts because they interact daily with students, are role models for students, teach about tobacco-use prevention in school curricula, and implement school tobacco-control policies. The prevalence of teenage smoking has been examined in numerous studies, but few have focused on the influence of school personnel and the characteristics of school personnel who enforce school nonsmoking policy. The purpose of this study was to determine the factors associated with junior high school personnel advising students to quit smoking. METHODS: School personnel (N = 7129) were recruited by cluster sampling from 60 junior high schools in Taiwan; of these, 5280 voluntarily returned self-administered, anonymous questionnaires (response rate = 74.06%) in 2004. RESULTS: Most personnel (70%) had advised students to quit smoking. School personnel who were older, male, responsible for teaching health, smokers, with positive attitude against tobacco, or with more knowledge of tobacco hazards were more likely to advise students to quit smoking. Personnel with more interest in and access to tobacco-related materials were more likely to advise students to quit smoking. Personnel who had received tobacco-prevention training were 2.41 times more likely to persuade students to quit smoking after adjusting for other factors. However, only half of the participants had ever had access to educational materials about tobacco use, and 8% had ever received training to prevent tobacco use. CONCLUSIONS: To reduce youth smoking prevalence, school tobacco-control programs should support tobacco-prevention training for school personnel. Adapted from the source document. JF - Journal of School Health AU - Chen, Ping-Ling AU - Huang, Wei-Gang AU - Chao, Kun-Yu AD - Director, ( ), Division of Maternal and Child Health, Bureau of Health Promotion, 2 Chang-Ching Street, Hsingjuang City, Taipei County 242, Taiwan Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 91 EP - 99 PB - Wiley-Blackwell, UK VL - 81 IS - 2 SN - 0022-4391, 0022-4391 KW - Smoking KW - Taiwan KW - Personnel KW - Cessation KW - Junior high schools KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855898969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+School+Health&rft.atitle=Factors+Associated+With+Taiwanese+Junior+High+School+Personnel+Advising+Students+to+Quit+Smoking&rft.au=Chen%2C+Ping-Ling%3BHuang%2C+Wei-Gang%3BChao%2C+Kun-Yu&rft.aulast=Chen&rft.aufirst=Ping-Ling&rft.date=2011-02-01&rft.volume=81&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fj.1746-1561.2010.00565.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Personnel; Smoking; Cessation; Prevalence; Junior high schools; Taiwan DO - http://dx.doi.org/10.1111/j.1746-1561.2010.00565.x ER - TY - JOUR T1 - Toxin profiles of five geographical isolates of Dinophysis spp. from North and South America. AN - 849431519; 21147146 AB - Marine dinoflagellates of the genus Dinophysis can produce toxins of the okadaic acid (OA) and pectenotoxin (PTX) groups. These lipophilic toxins accumulate in filter-feeding shellfish and cause an illness in consumers called diarrhetic shellfish poisoning (DSP). In 2008, a bloom of Dinophysis led to the closure of shellfish harvesting areas along the Texas coast, one of the first DSP-related closures in the U.S. This event resulted in a broad study of toxin production in isolates of Dinophysis spp. from U.S. waters. In the present study, we compared toxin profiles in geographical isolates of Dinophysis collected in the U.S. (Eel Pond, Woods Hole MA; Martha's Vineyard, MA; and Port Aransas Bay, Texas), and in those from Canada (Blacks Harbour, Bay of Fundy) and Chile (Reloncavi Estuary), when cultured in the laboratory under the same conditions. For each isolate, the mitochondrial cox1 gene was sequenced to assist in species identification. Strains from the northeastern U.S. and Canada were all assigned to Dinophysis acuminata, while those from Chile and Texas were most likely within the D. acuminata complex whereas precise species designation could not be made with this marker. Toxins were detected in all Dinophysis isolates and each isolate had a different profile. Toxin profiles of isolates from Eel Pond, Martha's Vineyard, and Bay of Fundy were most similar, in that they all contained OA, DTX1, and PTX2. The Eel Pond isolate also contained OA-D8 and DTX1-D7, and low levels (unconfirmed structurally) of DTX1-D8 and DTX1-D9. D. acuminata from Martha's Vineyard produced DTX1-D7, along with OA, DTX1, and PTX2, as identified in both the cells and the culture medium. D. acuminata from the Bay of Fundy produced DTX1 and PTX2, as found in both cells and culture medium, while only trace amounts of OA were detected in the medium. The Dinophysis strain from Texas only produced OA, and the one from Chile only PTX2, as confirmed in both cells and culture medium. Published by Elsevier Ltd. JF - Toxicon : official journal of the International Society on Toxinology AU - Fux, Elie AU - Smith, Juliette L AU - Tong, Mengmeng AU - Guzmán, Leonardo AU - Anderson, Donald M AD - U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA. eliefux@hotmail.com Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 275 EP - 287 VL - 57 IS - 2 KW - Marine Toxins KW - 0 KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Index Medicus KW - United States KW - Mass Spectrometry KW - Cyclooxygenase 1 -- chemistry KW - Canada KW - Chromatography, Liquid KW - Cyclooxygenase 1 -- genetics KW - Chile KW - Sequence Analysis, DNA KW - Geography KW - Dinoflagellida -- isolation & purification KW - Dinoflagellida -- genetics KW - Marine Toxins -- isolation & purification KW - Marine Toxins -- chemistry KW - Dinoflagellida -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849431519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Toxin+profiles+of+five+geographical+isolates+of+Dinophysis+spp.+from+North+and+South+America.&rft.au=Fux%2C+Elie%3BSmith%2C+Juliette+L%3BTong%2C+Mengmeng%3BGuzm%C3%A1n%2C+Leonardo%3BAnderson%2C+Donald+M&rft.aulast=Fux&rft.aufirst=Elie&rft.date=2011-02-01&rft.volume=57&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=1879-3150&rft_id=info:doi/10.1016%2Fj.toxicon.2010.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-16 N1 - Date created - 2011-02-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxicon.2010.12.002 ER - TY - JOUR T1 - Parallel Algorithm to Analyze the Brain Signals: Application on Epileptic Spikes AN - 847604640; 20703581 AB - In the current work, we have proposed a parallel algorithm for the recognition of Epileptic Spikes (ES) in EEG. The automated systems are used in biomedical field to help the doctors and pathologist by producing the result of an inspection in real time. Generally, the biomedical signal data to be processed are very large in size. A uniprocessor computer is having its own limitation regarding its speed. So the fastest available computer with latest configuration also may not produce results in real time for the immense computation. Parallel computing can be proved as a useful tool for processing the huge data with higher speed. In the proposed algorithm 'Data Parallelism' has been applied where multiple processors perform the same operation on different part of the data to produce fast result. All the processors are interconnected with each other by an interconnection network. The complexity of the algorithm was analyzed as Θ((n+δn)/N) where, 'n' is the length of the input data, 'N' is the number of processor used in the algorithm and 'δn' is the amount of overlapped data between two consecutive intermediate processors (IPs). This algorithm is scalable as the level of parallelism increase linearly with the increase in number of processors. The algorithm has been implemented in Message Passing Interface (MPI). It was tested with 60 min recorded EEG signal data files. The recognition rate of ES on an average was 95.68%.[PUBLICATION ABSTRACT] JF - Journal of Medical Systems AU - Keshri, Anup Kumar AU - Das, Barda Nand AU - Mallick, Dheeresh Kumar AU - Sinha, Rakesh Kumar Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 93 EP - 104 CY - New York PB - Springer Science & Business Media VL - 35 IS - 1 SN - 0148-5598 KW - Medical Sciences--Computer Applications KW - Parallel processing KW - Algorithms KW - Epilepsy KW - Electroencephalography KW - Medical diagnosis KW - Rats KW - Brain -- physiopathology KW - Software KW - Animals KW - Computers KW - Electroencephalography -- methods KW - Male KW - Image Interpretation, Computer-Assisted -- instrumentation KW - Signal Processing, Computer-Assisted -- instrumentation KW - Epilepsy -- diagnosis KW - Electroencephalography -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847604640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomputing&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Systems&rft.atitle=Parallel+Algorithm+to+Analyze+the+Brain+Signals%3A+Application+on+Epileptic+Spikes&rft.au=Keshri%2C+Anup+Kumar%3BDas%2C+Barda+Nand%3BMallick%2C+Dheeresh+Kumar%3BSinha%2C+Rakesh+Kumar&rft.aulast=Keshri&rft.aufirst=Anup&rft.date=2011-02-01&rft.volume=35&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Systems&rft.issn=01485598&rft_id=info:doi/10.1007%2Fs10916-009-9345-y LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2011 N1 - Document feature - References N1 - Last updated - 2014-07-26 DO - http://dx.doi.org/10.1007/s10916-009-9345-y ER - TY - JOUR T1 - GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. AN - 847594911; 21037224 AB - Associations between bladder cancer risk and NAT2 and GSTM1 polymorphisms have emerged as some of the most consistent findings in the genetic epidemiology of common metabolic polymorphisms and cancer, but their interaction with tobacco use, intensity and duration remain unclear. In a New England population-based case-control study of urothelial carcinoma, we collected mouthwash samples from 1088 of 1171 cases (92.9%) and 1282 of 1418 controls (91.2%) for genotype analysis of GSTM1, GSTT1 and NAT2 polymorphisms. Odds ratios and 95% confidence intervals of bladder cancer among New England Bladder Cancer Study subjects with one or two inactive GSTM1 alleles (i.e. the 'null' genotype) were 1.26 (0.85-1.88) and 1.54 (1.05-2.25), respectively (P-trend = 0.008), compared with those with two active copies. GSTT1 inactive alleles were not associated with risk. NAT2 slow acetylation status was not associated with risk among never (1.04; 0.71-1.51), former (0.95; 0.75-1.20) or current smokers (1.33; 0.91-1.95); however, a relationship emerged when smoking intensity was evaluated. Among slow acetylators who ever smoked at least 40 cigarettes/day, risk was elevated among ever (1.82; 1.14-2.91, P-interaction = 0.07) and current heavy smokers (3.16; 1.22-8.19, P-interaction = 0.03) compared with rapid acetylators in each category; but was not observed at lower intensities. In contrast, the effect of GSTM1-null genotype was not greater among smokers, regardless of intensity. Meta-analysis of the NAT2 associations with bladder cancer showed a highly significant relationship. Findings from this large USA population-based study provided evidence that the NAT2 slow acetylation genotype interacts with tobacco smoking as a function of exposure intensity. JF - Carcinogenesis AU - Moore, L E AU - Baris, D R AU - Figueroa, J D AU - Garcia-Closas, M AU - Karagas, M R AU - Schwenn, M R AU - Johnson, A T AU - Lubin, J H AU - Hein, D W AU - Dagnall, C L AU - Colt, J S AU - Kida, M AU - Jones, M A AU - Schned, A R AU - Cherala, S S AU - Chanock, S J AU - Cantor, K P AU - Silverman, D T AU - Rothman, N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. moorele@mail.nih.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 182 EP - 189 VL - 32 IS - 2 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Genotype KW - Risk KW - Acetylation KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Urinary Bladder Neoplasms -- etiology KW - Urinary Bladder Neoplasms -- genetics KW - Smoking -- adverse effects KW - Glutathione Transferase -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847594911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=GSTM1+null+and+NAT2+slow+acetylation+genotypes%2C+smoking+intensity+and+bladder+cancer+risk%3A+results+from+the+New+England+bladder+cancer+study+and+NAT2+meta-analysis.&rft.au=Moore%2C+L+E%3BBaris%2C+D+R%3BFigueroa%2C+J+D%3BGarcia-Closas%2C+M%3BKaragas%2C+M+R%3BSchwenn%2C+M+R%3BJohnson%2C+A+T%3BLubin%2C+J+H%3BHein%2C+D+W%3BDagnall%2C+C+L%3BColt%2C+J+S%3BKida%2C+M%3BJones%2C+M+A%3BSchned%2C+A+R%3BCherala%2C+S+S%3BChanock%2C+S+J%3BCantor%2C+K+P%3BSilverman%2C+D+T%3BRothman%2C+N&rft.aulast=Moore&rft.aufirst=L&rft.date=2011-02-01&rft.volume=32&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq223 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-07 N1 - Date created - 2011-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Anticancer Res. 2009 May;29(5):1709-14 [19443391] Stat Med. 2002 Jun 15;21(11):1539-58 [12111919] Cancer Res. 1988 Jul 1;48(13):3849-52 [3378220] Int J Technol Assess Health Care. 1990;6(1):5-30 [2361819] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Cancer Epidemiol Biomarkers Prev. 1994 Mar;3(2):173-5 [8049640] Cancer Res. 1998 Aug 15;58(16):3603-10 [9721868] Mutat Res. 2005 Mar 7;581(1-2):97-104 [15725609] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Urol Int. 2005;75(4):360-4 [16327307] Stat Med. 2006 Oct 30;25(20):3443-57 [16345038] BMC Cancer. 2006;6:239 [17026750] Cancer Lett. 2007 Jan 8;245(1-2):51-60 [16504378] Int J Cancer. 2007 May 15;120(10):2208-13 [17290402] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Int J Epidemiol. 2007 Feb;36(1):236-41 [17510079] Environ Health. 2007;6:39 [18053222] Carcinogenesis. 2008 Jul;29(7):1386-93 [18544563] Carcinogenesis. 2008 Aug;29(8):1467-74 [18550573] Cancer Genet Cytogenet. 2009 Apr 15;190(2):101-7 [19380028] Anticancer Res. 2009 May;29(5):1631-5 [19443378] Cancer Detect Prev. 2009;32(5-6):416-23 [19303722] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] Mutat Res. 2001 Oct 1;482(1-2):47-55 [11535248] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq223 ER - TY - JOUR T1 - Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms. AN - 847281284; 20920542 AB - Black cohosh, red clover, hops, and chasteberry are botanicals commonly used to alleviate menopausal symptoms in the US, and are examined in this study as part of a FDA Office of Women's Health research collaboration to expand knowledge on the safety of these botanical products. Computational approaches using classic (quantitative) structure-activity relationships ((Q)SAR), probabilistic reasoning, machine learning methods, and human expert rule-based systems were employed to deliver human hepatobiliary adverse effect predictions. The objective is to profile and analyze constituents that are alerting for the human hepatobiliary adverse effects. Computational analysis of positively predicted constituents showed that common structural features contributing to the hepatobiliary adverse effect predictions contain phenolic, flavone, isoflavone, glucoside conjugated flavone and isoflavone, and 4-hydroxyacetophenone structures. Specifically, protocatechuic acid from black cohosh, benzofuran and 4-vinylphenol from chasteberry, and xanthohumol I from hops were botanical constituents predicted positive for liver toxicity endpoints and were also confirmed with literature findings. However, comparison between the estimated human exposure to these botanical constituents and the LOAEL and NOAEL in published animal liver toxicology studies for these constituents demonstrated varying margins of safety. This study will serve as regulatory decision support information for regulators at the FDA to help with the process of prioritizing chemicals for testing. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Wang, Yun-Jan AU - Dou, Jinhui AU - Cross, Kevin P AU - Valerio, Luis G AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 111 EP - 124 VL - 59 IS - 1 KW - Plant Extracts KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Probability KW - Software KW - Dose-Response Relationship, Drug KW - Humans KW - Expert Systems KW - Risk Assessment KW - United States Food and Drug Administration KW - No-Observed-Adverse-Effect Level KW - Quantitative Structure-Activity Relationship KW - Risk Factors KW - Toxicity Tests KW - Female KW - Chemical and Drug Induced Liver Injury -- etiology KW - Computer Simulation KW - Women's Health KW - Models, Molecular KW - Liver -- drug effects KW - Artificial Intelligence KW - Menopause -- drug effects KW - Plant Extracts -- chemistry KW - Plant Extracts -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847281284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Computational+analysis+for+hepatic+safety+signals+of+constituents+present+in+botanical+extracts+widely+used+by+women+in+the+United+States+for+treatment+of+menopausal+symptoms.&rft.au=Wang%2C+Yun-Jan%3BDou%2C+Jinhui%3BCross%2C+Kevin+P%3BValerio%2C+Luis+G&rft.aulast=Wang&rft.aufirst=Yun-Jan&rft.date=2011-02-01&rft.volume=59&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2010.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-11 N1 - Date created - 2011-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2010.09.012 ER - TY - JOUR T1 - Occupational lung cancer in US women, 1984-1998. AN - 847278896; 21259296 AB - Lung cancer is the leading cause of cancer death in US women, accounting for 72,130 deaths in 2006. In addition to smoking cessation, further reduction of the burden of lung cancer mortality can be made by preventing exposure to occupational lung carcinogens. Data for occupational exposures and health outcomes of US working women are limited. Population-based mortality data for 4,570,711 women who died between 1984 and 1998 in 27 US States were used to evaluate lung cancer proportionate mortality over time by the usual occupation and industry reported on death certificates. Lung cancer proportionate mortality ratios were adjusted for smoking, using data from the National Health Interview Survey (NHIS) and the American Cancer Society's Cancer Prevention Study II. Analyses revealed that 194,382 white, 18,225 Black and 1,515 Hispanic women died 1984-1998 with lung cancer reported as the underlying cause of death. Following adjustment for smoking, significant excess proportionate lung cancer mortality was observed among US women working in the US manufacturing; transportation; retail trade; agriculture, forestry, and fishing; and nursing/personal care industries. Women employed in precision production, technical, managerial, professional specialty, and administrative occupations experienced some of the highest significantly excess proportionate lung cancer mortality during 1984-1998. The results of our study point to significantly elevated risks for lung cancer after adjustment for smoking among women in several occupations and industries. Because 6-17% of lung cancer in US males is attributable to known exposures to occupational carcinogens, and since synergistic interactions between cigarette smoke and other occupational lung carcinogens have been noted, it is important to continue research into the effects of occupational exposures on working men and women. Copyright © 2010 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Robinson, Cynthia F AU - Sullivan, Patricia A AU - Li, Jia AU - Walker, James T AD - The National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA. CFRobinson@cdc.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 102 EP - 117 VL - 54 IS - 2 KW - Index Medicus KW - Young Adult KW - Humans KW - Aged KW - Risk Assessment -- methods KW - Aged, 80 and over KW - Adult KW - Confidence Intervals KW - Incidence KW - Industry -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Environmental Exposure -- adverse effects KW - United States -- epidemiology KW - Female KW - Prevalence KW - Occupational Exposure -- statistics & numerical data KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Lung Neoplasms -- mortality KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847278896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupational+lung+cancer+in+US+women%2C+1984-1998.&rft.au=Robinson%2C+Cynthia+F%3BSullivan%2C+Patricia+A%3BLi%2C+Jia%3BWalker%2C+James+T&rft.aulast=Robinson&rft.aufirst=Cynthia&rft.date=2011-02-01&rft.volume=54&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20905 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-05 N1 - Date created - 2011-01-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ajim.20905 ER - TY - JOUR T1 - Identification and measurement of diacetyl substitutes in dry bakery mix production. AN - 846898128; 21253982 AB - In 2008, a company using multiple buttermilk flavorings in the production of dry bakery mixes replaced one liquid flavoring containing 15-20% diacetyl with a proprietary substitute meant to lower occupational risk for diacetyl-related bronchiolitis obliterans. Subsequently, the National Institute for Occupational Safety and Health (NIOSH) evaluated buttermilk flavoring-related exposures at this company's facility, with a focus on measuring ketones by several methods. Volatile organic compounds (VOCs) were evaluated in the headspaces of six bulk flavorings samples, including the substitute buttermilk flavoring. Ketones were evaluated in workplace air via area and personal samples collected during batch preparation of the substitute buttermilk flavoring and production of a bakery mix containing the same flavoring. Air samples were evaluated using five different methods: NIOSH 2549, Modified OSHA PV2118, OSHA 1013, NIOSH Draft Procedure SMP2, and evacuated canisters. Of five buttermilk flavorings from five different flavorings manufacturers, diacetyl was present in four, including the substitute flavoring; acetoin in two; 2,3-pentanedione in four; 2,3-hexanedione in one; and 2,3-heptanedione in three. Among material safety data sheets (MSDS) for four flavorings, only one listed a hazardous ingredient, which was acetoin. The predominant flavoring ingredient identified in the headspace of the substitute flavoring was 2,3-pentanedione; all other chemicals noted above were also present. Diacetyl and 2,3-pentanedione were measured in workplace air via evacuated canisters. In one area and one personal air sample, 2,3-pentanedione was measured by OSHA Method 1013 at concentrations of 78 and 91 ppb, respectively. Without their or the employer's knowledge, workers who used buttermilk flavorings were exposed to substitute ketones from many flavorings manufacturers. Because 2,3-pentanedione, 2,3-hexanedione, and 2,3-heptanedione all share the same functional α-diketone group as diacetyl, these compounds also may share diacetyl's mechanism of toxicity. Until more is known about 2,3-pentanedione and other α-diketone compounds, they should not be assumed to be safe. Companies using artificial buttermilk flavorings should use a precautionary approach that assumes these flavorings pose a health risk and limit exposures through engineering and administrative controls and use of personal protective equipment. JF - Journal of occupational and environmental hygiene AU - Day, Gregory AU - LeBouf, Ryan AU - Grote, Ardith AU - Pendergrass, Stephanie AU - Cummings, Kristin AU - Kreiss, Kathleen AU - Kullman, Greg AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505-2888, USA. gday@cdc.gov Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 93 EP - 103 VL - 8 IS - 2 KW - Air Pollutants, Occupational KW - 0 KW - Flavoring Agents KW - Ketones KW - Volatile Organic Compounds KW - Diacetyl KW - K324J5K4HM KW - Index Medicus KW - United States KW - Occupational Health KW - Humans KW - Ketones -- analysis KW - Flavoring Agents -- analysis KW - National Institute for Occupational Safety and Health (U.S.) KW - Diacetyl -- analysis KW - Air Pollutants, Occupational -- analysis KW - Diacetyl -- analogs & derivatives KW - Food Handling KW - Volatile Organic Compounds -- analysis KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846898128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Identification+and+measurement+of+diacetyl+substitutes+in+dry+bakery+mix+production.&rft.au=Day%2C+Gregory%3BLeBouf%2C+Ryan%3BGrote%2C+Ardith%3BPendergrass%2C+Stephanie%3BCummings%2C+Kristin%3BKreiss%2C+Kathleen%3BKullman%2C+Greg&rft.aulast=Day&rft.aufirst=Gregory&rft.date=2011-02-01&rft.volume=8&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2011.547148 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-03 N1 - Date created - 2011-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459624.2011.547148 ER - TY - JOUR T1 - Bacterial HA1 vaccine against pandemic H5N1 influenza virus: evidence of oligomerization, hemagglutination, and cross-protective immunity in ferrets. AN - 840349898; 21084473 AB - The impending influenza virus pandemic requires global vaccination to prevent large-scale mortality and morbidity, but traditional influenza virus vaccine production is too slow for rapid responses. We have developed bacterial systems for expression and purification of properly folded functional hemagglutinin as a rapid response to emerging pandemic strains. A recombinant H5N1 (A/Vietnam/1203/2004) hemagglutinin globular domain (HA1) was produced in Escherichia coli under controlled redox refolding conditions. Importantly, the properly folded HA1(1-320), i.e., HA1 lacking amino acids 321 to 330, contained ≥75% functional oligomers without addition of foreign oligomerization sequence. Site-directed mutagenesis mapped the oligomerization signal to the HA1 N-terminal Ile-Cys-Ile residues at positions 3 to 5. The purified HA1 oligomers (but not monomers) bound fetuin and agglutinated red blood cells. Upon immunization of rabbits, the oligomeric HA1(1-320) elicited potent neutralizing antibodies against homologous and heterologous H5N1 viruses more rapidly than HA1(28-320) containing only monomers. Ferrets vaccinated with oligomeric HA1 (but not monomeric HA1 with the N terminus deleted) at 15 and 3 μg/dose were fully protected from lethality and weight loss after challenge with homologous H5N1 (A/Vietnam/1203/2004, clade 1) virus, as well as heterologous clade 2.2 H5N1 (A/WooperSwan/Mongolia/244/2005) virus. Protection was associated with a significant reduction in viral loads in the nasal washes of homologous and heterologous virus challenged ferrets. This is the first study that describes the presence of an N-terminal oligomerization sequence in the globular domain of influenza virus hemagglutinin. Our findings suggest that functional oligomeric rHA1-based vaccines can be produced efficiently in bacterial systems and can be easily upscaled in response to a pandemic influenza virus threat. JF - Journal of virology AU - Khurana, Surender AU - Verma, Swati AU - Verma, Nitin AU - Crevar, Corey J AU - Carter, Donald M AU - Manischewitz, Jody AU - King, Lisa R AU - Ross, Ted M AU - Golding, Hana AD - Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2011/02// PY - 2011 DA - February 2011 SP - 1246 EP - 1256 VL - 85 IS - 3 KW - Antibodies, Neutralizing KW - 0 KW - Antibodies, Viral KW - Hemagglutinin Glycoproteins, Influenza Virus KW - Influenza Vaccines KW - Vaccines, Synthetic KW - alpha-Fetoproteins KW - Index Medicus KW - Animals KW - Orthomyxoviridae Infections -- prevention & control KW - Disease Models, Animal KW - Escherichia coli -- genetics KW - Rabbits KW - Vaccines, Synthetic -- isolation & purification KW - Protein Multimerization KW - Protein Binding KW - Hemagglutination KW - Nasal Mucosa -- virology KW - Viral Load KW - Antibodies, Viral -- blood KW - Genetic Vectors KW - Vaccines, Synthetic -- immunology KW - Ferrets KW - Vaccines, Synthetic -- administration & dosage KW - Orthomyxoviridae Infections -- mortality KW - Vaccines, Synthetic -- genetics KW - Antibodies, Neutralizing -- blood KW - alpha-Fetoproteins -- metabolism KW - Female KW - Survival Analysis KW - Influenza A Virus, H5N1 Subtype -- genetics KW - Hemagglutinin Glycoproteins, Influenza Virus -- immunology KW - Influenza Vaccines -- genetics KW - Influenza Vaccines -- isolation & purification KW - Influenza A Virus, H5N1 Subtype -- immunology KW - Hemagglutinin Glycoproteins, Influenza Virus -- isolation & purification KW - Influenza Vaccines -- immunology KW - Hemagglutinin Glycoproteins, Influenza Virus -- administration & dosage KW - Influenza Vaccines -- administration & dosage KW - Hemagglutinin Glycoproteins, Influenza Virus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/840349898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Bacterial+HA1+vaccine+against+pandemic+H5N1+influenza+virus%3A+evidence+of+oligomerization%2C+hemagglutination%2C+and+cross-protective+immunity+in+ferrets.&rft.au=Khurana%2C+Surender%3BVerma%2C+Swati%3BVerma%2C+Nitin%3BCrevar%2C+Corey+J%3BCarter%2C+Donald+M%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BRoss%2C+Ted+M%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2011-02-01&rft.volume=85&rft.issue=3&rft.spage=1246&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.02107-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-16 N1 - Date created - 2011-01-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 1996 Mar 15;217(2):452-8 [8610436] Cell. 1985 Feb;40(2):431-9 [3967299] J Infect Dis. 1997 Feb;175(2):342-51 [9203655] J Mol Biol. 2006 Feb 3;355(5):1143-55 [16343533] Vaccine. 2006 Mar 15;24(12):2176-85 [16310896] N Engl J Med. 2006 Mar 30;354(13):1343-51 [16571878] Am J Pathol. 2007 Oct;171(4):1215-23 [17717141] PLoS One. 2008;3(5):e2257 [18493310] J Virol. 2008 Jul;82(13):6200-8 [18417563] J Med Virol. 2008 Nov;80(11):1972-83 [18814259] PLoS Med. 2009 Apr 21;6(4):e1000049 [19381279] J Virol. 2010 Feb;84(4):1715-21 [20007271] Sci Transl Med. 2010 Jan 20;2(15):15ra5 [20371470] Science. 2010 Apr 16;328(5976):357-60 [20339031] PLoS One. 2010;5(7):e11548 [20634959] PLoS One. 2010;5(7):e11694 [20661476] J Virol. 2010 Oct;84(19):10366-74 [20686020] PLoS One. 2010;5(9). pii: e12466. doi: 10.1371/journal.pone.0012466 [20824188] J Virol. 1986 Feb;57(2):603-13 [3003392] Nature. 1986 Jan 16-22;319(6050):199-203 [3945310] J Cell Biol. 1986 Oct;103(4):1179-91 [2429970] J Virol. 1986 Dec;60(3):833-9 [3783818] J Cell Biol. 1988 Mar;106(3):629-39 [3279048] Annu Rev Immunol. 1990;8:737-71 [2188678] J Cell Biol. 1990 Aug;111(2):409-20 [2380242] J Virol. 1993 Jun;67(6):3048-60 [8497042] Nature. 1995 Jul 6;376(6535):92-4 [7596443] Vaccine. 2001 Feb 8;19(13-14):1732-7 [11166898] J Virol. 2002 May;76(9):4420-9 [11932409] Rev Med Virol. 2003 Mar-Apr;13(2):85-97 [12627392] Science. 2004 Mar 19;303(5665):1866-70 [14764887] Lab Anim (NY). 2004 Oct;33(9):50-3 [15457202] Nature. 1981 Jan 29;289(5796):366-73 [7464906] Nature. 1981 Jan 29;289(5796):373-8 [6162101] J Infect Dis. 1996 Oct;174(4):838-41 [8843225] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.02107-10 ER - TY - JOUR T1 - Comparison and thinking on tracing historical source and contemporary understanding of Chinese materia medica toxicity AN - 1356924914; 14972939 AB - The toxicity of Chinese materia medica (CMM) is one of cores of the property theory of CMM. From the perspective of history, the literature source of the understanding on CMM toxicity was traced; The traditional and contemporary understanding about the meaning and classification of CMM toxicity was compared and analyzed; The ideas on CMM toxicity with the feature of tradition, experience, objectivity, the integrity of the concept, and some of the controllability were proposed; The theory and practice of traditional Chinese medicines should be combined in order to effectively integrate and apply various modern scientific and technical methods, and create new ideas about toxicity studies of CMM, which has the important significance on the comprehensive understanding about CMM toxicity, strengthening the research on CMM toxicity, and promoting the safety of CMM in clinical use. JF - Zhongcaoyao - Chinese Traditional and Herbal Drugs AU - Xia, D-S AD - Center for Drug Reevaluation, State Food and Drug Administration, Beijing 100045, China, xiadongsheng@cdr.gov.cn Y1 - 2011/02// PY - 2011 DA - Feb 2011 SP - 209 EP - 213 VL - 42 IS - 2 SN - 0253-2670, 0253-2670 KW - Toxicology Abstracts KW - Classification KW - Herbal medicines KW - Toxicity KW - Traditional Chinese Medicine KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356924914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongcaoyao+-+Chinese+Traditional+and+Herbal+Drugs&rft.atitle=Comparison+and+thinking+on+tracing+historical+source+and+contemporary+understanding+of+Chinese+materia+medica+toxicity&rft.au=Xia%2C+D-S&rft.aulast=Xia&rft.aufirst=D-S&rft.date=2011-02-01&rft.volume=42&rft.issue=2&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Zhongcaoyao+-+Chinese+Traditional+and+Herbal+Drugs&rft.issn=02532670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Classification; Herbal medicines; Toxicity; Traditional Chinese Medicine ER - TY - JOUR T1 - Rotenone, Paraquat, and Parkinson's Disease AN - 1671475570; 15090559 AB - Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative stress are associated with PD or clinical features of parkinsonism in humans. We assessed lifetime use of pesticides selected by mechanism in a case-control study nested in the Agricultural Health Study (AHS). PD was diagnosed by movement disorders specialists. Controls were a stratified random sample of all AHS participants frequency-matched to cases by age, sex, and state at approximately three controls: one case. In 110 PD cases and 358 controls, PD was associated with use of a group of pesticides that inhibit mitochondrial complex I [odds ratio (OR) = 1.7; 95% confidence interval (CI), 1.0-2.8] including rotenone (OR = 2.5; 95% CI, 1.3-4.7) and with use of a group of pesticides that cause oxidative stress (OR = 2.0; 95% CI, 1.2-3.6), including paraquat (OR = 2.5; 95% CI, 1.4-4.7). PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. JF - Environmental Health Perspectives AU - Tanner, Caroline M AU - Kamel, Freya AU - Ross, GWebster AU - Hoppin, Jane A AU - Goldman, Samuel M AU - Korell, Monica AU - Marras, Connie AU - Bhudhikanok, Grace S AU - Kasten, Meike AU - Chade, Anabel R AU - Comyns, Kathleen AU - Richards, Marie Barber AU - Meng, Cheryl AU - Priestley, Benjamin AU - Fernandez, Hubert H AU - Cambi, Franca AU - Umbach, David M AU - Blair, Aaron AU - Sandler, Dale P AU - Langston, JWilliam AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/01/26/ PY - 2011 DA - 2011 Jan 26 SP - 866 EP - 872 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 6 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - aging KW - agricultural epidemiology KW - environmental epidemiology KW - epidemiology KW - fungicides KW - herbicides KW - insecticides KW - persistent organic pollutants KW - pesticides KW - Genetics KW - Control equipment KW - Parkinson's disease KW - Human KW - Pesticides KW - Health KW - Stresses KW - Paraquat UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671475570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Rotenone%2C+Paraquat%2C+and+Parkinson%27s+Disease&rft.au=Tanner%2C+Caroline+M%3BKamel%2C+Freya%3BRoss%2C+GWebster%3BHoppin%2C+Jane+A%3BGoldman%2C+Samuel+M%3BKorell%2C+Monica%3BMarras%2C+Connie%3BBhudhikanok%2C+Grace+S%3BKasten%2C+Meike%3BChade%2C+Anabel+R%3BComyns%2C+Kathleen%3BRichards%2C+Marie+Barber%3BMeng%2C+Cheryl%3BPriestley%2C+Benjamin%3BFernandez%2C+Hubert+H%3BCambi%2C+Franca%3BUmbach%2C+David+M%3BBlair%2C+Aaron%3BSandler%2C+Dale+P%3BLangston%2C+JWilliam&rft.aulast=Tanner&rft.aufirst=Caroline&rft.date=2011-01-26&rft.volume=119&rft.issue=6&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002839 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002839 ER - TY - JOUR T1 - Separation characteristics of fatty acid methyl esters using SLB-IL111, a new ionic liquid coated capillary gas chromatographic column AN - 1635022756; 15117743 AB - The ionic liquid SLB-IL111 column, available from Supelco Inc., is a novel fused capillary gas chromatography (GC) column capable of providing enhanced separations of fatty acid methyl esters (FAMEs) compared to the highly polar cyanopropyl siloxane columns currently recommended for the separation of cis- and trans isomers of fatty acids (FAs), and marketed as SP-2560 and CP-Sil 88. The SLB-IL111 column was operated isothermal at 168 [deg]C, with hydrogen as carrier gas at 1.0 mL/min, and the elution profile was characterized using authentic GC standards and synthetic mono-unsaturated fatty acids (MUFAs) and conjugated linoleic acid (CLA) isomers as test mixtures. The SLB-IL111 column provided an improved separation of cis- and trans-18:1 and cis/trans CLA isomers. This is the first direct GC separation of c9,t11- from t7,c9-CLA, and t15-18:1 from c9-18:1, both of which previously required complimentary techniques for their analysis using cyanopropyl siloxane columns. The SLB-IL111 column also provided partial resolution of t13/t14-18:1, c8- from c6/c7-18:1, and for several t,t-CLA isomer pairs. This column also provided elution profiles of the geometric and positional isomers of the 16:1, 20:1 and 18:3 FAMEs that were complementary to those obtained using the cyanopropyl siloxane columns. However, on the SLB-IL111 column the saturated FAs eluted between the cis- and trans MUFAs unlike cyanopropyl siloxane columns that gave a clear separation of most saturated FAs. These differences in elution pattern can be exploited to obtain a more complete analysis of complex lipid mixtures present in ruminant fats. JF - Journal of Chromatography A AU - Delmonte, Pierluigi AU - Kia, Ali-Reza Fardin AU - Kramer, John KG AU - Mossoba, Magdi M AU - Sidisky, Len AU - Rader, Jeanne I AD - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA Y1 - 2011/01/21/ PY - 2011 DA - 2011 Jan 21 SP - 545 EP - 554 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 3 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Ionic liquids KW - Gas chromatography (GC) KW - GLC KW - trans fat KW - Fatty acids KW - Conjugated linoleic acid (CLA) KW - cis- and trans-MUFA KW - Separation of synthetic CLA isomers KW - Separation of synthetic MUFA isomers KW - GC separations on ionic liquid columns KW - SP-2560 KW - CP-Sil-88 KW - SLB-IL111 KW - Chromatographic techniques KW - Lipids KW - Hydrogen KW - Ruminants KW - Linoleic acid KW - Fatty Acids KW - Esters KW - Profiles KW - Analytical Methods KW - Acids KW - Fats KW - Standards KW - Complex lipids KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635022756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Separation+characteristics+of+fatty+acid+methyl+esters+using+SLB-IL111%2C+a+new+ionic+liquid+coated+capillary+gas+chromatographic+column&rft.au=Delmonte%2C+Pierluigi%3BKia%2C+Ali-Reza+Fardin%3BKramer%2C+John+KG%3BMossoba%2C+Magdi+M%3BSidisky%2C+Len%3BRader%2C+Jeanne+I&rft.aulast=Delmonte&rft.aufirst=Pierluigi&rft.date=2011-01-21&rft.volume=1218&rft.issue=3&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.11.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Fatty acids; Fats; Esters; Complex lipids; Linoleic acid; Analytical Methods; Profiles; Acids; Lipids; Fatty Acids; Standards; Hydrogen; Ruminants DO - http://dx.doi.org/10.1016/j.chroma.2010.11.072 ER - TY - JOUR T1 - Surface swabbing technique for the rapid screening for pesticides using ambient pressure desorption ionization with high-resolution mass spectrometry AN - 901683249; 15268036 AB - A rapid screening method for pesticides has been developed to promote more efficient processing of produce entering the United States. Foam swabs were used to recover a multiclass mixture of 132 pesticides from the surfaces of grapes, apples, and oranges. The swabs were analyzed using direct analysis in real time (DART) ionization coupled with a high-resolution Exactive Orbitrap(TM) mass spectrometer. By using a DART helium temperature gradient from 100-350 degree C over 3 min, a minimal separation of analytes based on volatility differences was achieved. This, combined with the Exactive's mass resolution of 100 000, allowed the chromatographic step, along with the typical compositing and extraction steps associated with gas chromatography/mass spectrometry (GC/MS) or liquid chromatography/mass spectrometry (LC/MS) approaches, to be eliminated. Detection of 86% of the analytes present was consistently achieved at levels of 2 ng/g (per each apple or orange) and 10 ng/g (per grape). A resolution study was conducted with four pairs of isobaric compounds analyzed at a mass resolution of 100 000. Baseline separation was achieved with analyte ions differing in mass by 25 ppm and analyte ions with a mass difference of 10 ppm were partially resolved. In addition, field samples that had undergone traditional sample preparation using QuEChERS (quick, easy, cheap, rugged, and safe) were analyzed using both LC/MS and DART-MS and the results from the two techniques were found to be comparable in terms of identification of the pesticides present. The use of swabs greatly increased sample throughput by reducing sample preparation and analysis time. Published in 2010 by John Wiley & Sons, Ltd. JF - Rapid Communications in Mass Spectrometry AU - Edison, Sara E AU - Lin, Lora A AU - Gamble, Bryan M AU - Wong, Jon AU - Zhang, Kai AD - Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH, USA, sara.edison@fda.hhs.gov Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 127 EP - 139 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 1 SN - 1097-0231, 1097-0231 KW - Environment Abstracts KW - Ions KW - Desorption KW - Mass spectrometry KW - USA KW - Liquid chromatography KW - Gas chromatography KW - Pesticides KW - Economics KW - Malus KW - Helium KW - Vitaceae KW - uncertainty KW - ENA 09:Land Use & Planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901683249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+Communications+in+Mass+Spectrometry&rft.atitle=Surface+swabbing+technique+for+the+rapid+screening+for+pesticides+using+ambient+pressure+desorption+ionization+with+high-resolution+mass+spectrometry&rft.au=Edison%2C+Sara+E%3BLin%2C+Lora+A%3BGamble%2C+Bryan+M%3BWong%2C+Jon%3BZhang%2C+Kai&rft.aulast=Edison&rft.aufirst=Sara&rft.date=2011-01-15&rft.volume=25&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Rapid+Communications+in+Mass+Spectrometry&rft.issn=10970231&rft_id=info:doi/10.1002%2Frcm.4831 L2 - http://onlinelibrary.wiley.com/doi/10.1002/rcm.4831/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Ions; Desorption; Gas chromatography; Liquid chromatography; Economics; Pesticides; Helium; Mass spectrometry; uncertainty; Malus; Vitaceae; USA DO - http://dx.doi.org/10.1002/rcm.4831 ER - TY - JOUR T1 - No effect of meat, meat cooking preferences, meat mutagens or heme iron on lung cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial AN - 1017966960; 16690207 AB - Recent epidemiological studies have suggested that red and processed meat may increase the risk of lung cancer. Possible underlying mechanisms include mutagens produced during high-temperature cooking or preservation, or formed endogenously from heme iron in meat. We used data from 99,579 participants of both screened and nonscreened arms of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, aged 55-74 years, to investigate whether meat type, cooking method, doneness level, intake of specific meat mutagens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline] (DiMeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and benzo(a)pyrene (B(a)P)] and heme iron are associated with lung cancer. Participants' diet was assessed prospectively using a 124-item food frequency questionnaire and an additional meat-cooking module. Dietary data were used in conjunction with a database to estimate intake of MeIQx, DiMeIQx, PhIP, B(a)P and heme iron. After up to 8 years of follow-up, 782 incident lung cancer cases were ascertained. Lung cancer risk was not associated with the consumption of either red (men: HRQ5 vs. Q1 = 1.11, 95% CI = 0.79-1.56, Ptrend = 0.42; women: HRQ5 vs. Q1 = 1.30, 95% CI = 0.87-1.95, Ptrend = 0.65) or processed meat (men: HRQ5 vs. Q1 = 1.12, 95% CI = 0.83-1.53, Ptrend = 0.22; women: HRQ5 vs. Q1 = 0.98, 95% CI = 0.68-1.41, Ptrend = 0.32) in multivariable models. High-temperature cooking methods, level of meat doneness, meat mutagens and heme iron had no effect on lung cancer risk. In this population, we found no association between meat type, cooking method, doneness level or intake of specific meat mutagens or heme iron and lung cancer risk. JF - International Journal of Cancer AU - Tasevska, Natasa AU - Cross, Amanda J AU - Dodd, Kevin W AU - Ziegler, Regina G AU - Caporaso, Neil E AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, tasevskan@mail.nih.gov Y1 - 2011/01/15/ PY - 2011 DA - 2011 Jan 15 SP - 402 EP - 411 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 128 IS - 2 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Cooking KW - Diets KW - Iron KW - Lung cancer KW - Meat KW - Mutagens KW - Ovarian carcinoma KW - cooking KW - meat KW - ovarian carcinoma KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=No+effect+of+meat%2C+meat+cooking+preferences%2C+meat+mutagens+or+heme+iron+on+lung+cancer+risk+in+the+prostate%2C+lung%2C+colorectal+and+ovarian+cancer+screening+trial&rft.au=Tasevska%2C+Natasa%3BCross%2C+Amanda+J%3BDodd%2C+Kevin+W%3BZiegler%2C+Regina+G%3BCaporaso%2C+Neil+E%3BSinha%2C+Rashmi&rft.aulast=Tasevska&rft.aufirst=Natasa&rft.date=2011-01-15&rft.volume=128&rft.issue=2&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.25327 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.25327/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Meat; Diets; Mutagens; ovarian carcinoma; Cooking; meat; Ovarian carcinoma; cooking; Iron; Cancer; Lung cancer DO - http://dx.doi.org/10.1002/ijc.25327 ER - TY - JOUR T1 - Deciphering the Clinical Presentations, Pathogenesis, and Treatment of the Idiopathic Inflammatory Myopathies AN - 904465217; 14220143 AB - The idiopathic inflammatory myopathies or myositis syndromes (the most common forms are polymyositis, dermatomyositis, and inclusion body myositis) are systemic autoimmune diseases defined by chronic muscle weakness and inflammation of unknown etiology and result in significant morbidity and mortality. Research suggests that categorizing heterogeneous myositis syndromes into mutually exclusive and stable phenotypes by using clinical and immune response features is useful for predicting clinical signs and symptoms, associated genetic and environmental risk factors, and responses to therapy and prognosis. Knowledge of myositis phenotypes should enhance clinicians' ability to recognize and manage these rare disorders. JF - JAMA: Journal of the American Medical Association AU - Rider, Lisa G AU - Miller, Frederick W AD - Author Affiliations: Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland Y1 - 2011/01/12/ PY - 2011 DA - 2011 Jan 12 SP - 183 EP - 190 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 305 IS - 2 SN - 0098-7484, 0098-7484 KW - Risk Abstracts KW - Mortality KW - Etiology KW - autoimmune diseases KW - Muscles KW - Morbidity KW - Risk factors KW - Immune response KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904465217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Deciphering+the+Clinical+Presentations%2C+Pathogenesis%2C+and+Treatment+of+the+Idiopathic+Inflammatory+Myopathies&rft.au=Rider%2C+Lisa+G%3BMiller%2C+Frederick+W&rft.aulast=Rider&rft.aufirst=Lisa&rft.date=2011-01-12&rft.volume=305&rft.issue=2&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; Etiology; Risk factors; Muscles; autoimmune diseases; Immune response; Morbidity ER - TY - JOUR T1 - Epigenetics in tobacco smoke toxicology AN - 968182456; 16473264 AB - Tobacco is smoked by people worldwide. Burning tobacco results in combustion, pyrolysis, and other chemical reactions that expose the smoker to thousands of chemicals, causing harm. Several modes of action are involved in the toxicology of tobacco smoke, including epigenetic mechanisms. These epigenetic changes include methylation of DNA by covalent addition of a methyl group to the cytosine residue in a CpG site; posttranslational modification of amino tails of histones; and aberrant expression of microRNAs. Together, these major epigenetic mechanisms can affect whether a gene or set of genes is silenced or activated, which can lead to disruption in cellular function and cause a variety of diseases. Although epigenetic profiling is not yet recognized in toxicological sciences as a valid biomarker of potential hazardous effects of environmental agents, there is now a growing body of evidence that environmental exposures can induce epigenetic changes. In fully assessing the toxicologic impact of tobacco smoke, its epigenetic action should be considered. The effect of tobacco smoke by each of the major epigenetic mechanisms will be described in this review. Its effect involving DNA methylation has been the most studied, examining both global effect and specific gene targeting. Included in the discussion will be observations from disease studies in human populations and those involving animal models and in vitro cell culture systems. There are also several examples in which the epigenetic effects of individual constituents of tobacco smoke have been tested. Limitations of the available data and future challenges and opportunities will be addressed. JF - Current Topics In Toxicology AU - Hammons, G AU - Lyn-Cook, B AD - HFT 110, Office of Regulatory Activities, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA, ghammons@nctr.fda.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 63 EP - 78 VL - 7 SN - 0972-8228, 0972-8228 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Animal models KW - epigenetics KW - N:14820 KW - X:24380 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968182456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+In+Toxicology&rft.atitle=Epigenetics+in+tobacco+smoke+toxicology&rft.au=Hammons%2C+G%3BLyn-Cook%2C+B&rft.aulast=Hammons&rft.aufirst=G&rft.date=2011-01-01&rft.volume=7&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Current+Topics+In+Toxicology&rft.issn=09728228&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - epigenetics ER - TY - RPRT T1 - 2011 Strategic Plan for Autism Spectrum Disorder Research AN - 964173031; ED524623 AB - Autism spectrum disorder (ASD) affects an estimated 1% of children in the United States and yet many fundamental questions about the biology of ASD, potential risk factors, effective treatments and interventions, and impacts throughout life remain unanswered. Important advances have been made in understanding the complexity of ASD, but additional work is needed to fully understand how biological and external environmental factors contribute to ASD, identify the most effective interventions and services, and improve the quality of life for people with ASD and their families. The Interagency Autism Coordinating Committee (IACC) Strategic Plan for ASD Research was created with the intent to accelerate and inspire research that will profoundly improve the health and well-being of every person on the autism spectrum across the lifespan. The Plan provides a blueprint for autism research that is advisory to the Department of Health and Human Services and serves as a basis for partnerships with other agencies and private organizations involved in autism research and services. Under the Combating Autism Act of 2006, it must be updated on an annual basis. To this end, the 2011 Plan has been updated by the IACC to reflect important new scientific advances in the field over the past year, emerging areas of opportunity, and areas where more research is necessary. Input from the ASD community, advocacy groups, research funding organizations, and the scientific community has continued to be a critical aspect of the updating process. The 2011 Plan includes an additional 16 objectives and newly developed addendum sections for each chapter describing what has recently been learned, what gap areas have emerged, and what progress is being made in fulfilling the objectives. [For "2010 Strategic Plan for Autism Spectrum Disorder Research," see ED524616.] Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 104 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - American Recovery and Reinvestment Act 2009 KW - ERIC, Resources in Education (RIE) KW - Clinical Diagnosis KW - Federal Aid KW - Private Financial Support KW - Pervasive Developmental Disorders KW - Intervention KW - Adults KW - Portfolios (Background Materials) KW - Research Needs KW - Access to Information KW - Federal Programs KW - Access to Health Care KW - Research KW - Financial Support KW - At Risk Persons KW - Etiology KW - Needs Assessment KW - Prevention KW - Federal Legislation KW - Public Agencies KW - Guides KW - Autism KW - Strategic Planning KW - Private Agencies KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964173031?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Healthy People: A 2020 Vision for the Social Determinants Approach AN - 925740294; 201204684 AB - For the past three decades, the Healthy People initiative has represented an ambitious yet achievable health promotion and disease prevention agenda for the nation. The recently released fourth version-Healthy People 2020-builds on the foundations of prior iterations while newly embracing and elevating a comprehensive "social determinants" perspective. By clearly articulating a new overarching goal to "create social and physical environments that promote good health for all" and a new topic area dedicated to defining the social determinants of health approach, it breaks new ground. Specifically, the 2020 plan emphasizes the need to consider factors such as poverty, education, and numerous aspects of the social structure that not only influence the health of populations but also limit the ability of many to achieve health equity. Improving health is too multifaceted to be left to those working in the health sector alone. Using a social determinants approach can reframe the way the public, policy makers, and the private sector think about achieving and sustaining health. This article describes why such a social determinants approach can enhance our collective efforts to improve population health. This is achieved by defining the context for this new perspective, the process by which the Healthy People 2020 goals and objectives were developed, and the challenges and opportunities ahead. Adding this broad, social determinants perspective and vision for shared societal responsibility for change leaves Healthy People 2020 poised to promote a stronger legacy for a healthier nation and reaffirm a unity of purpose for the future. [Reprinted by permission of Sage Publications Inc., copyright, the Society for Public Health Education.] JF - Health Education & Behavior AU - Koh, Howard K AU - Piotrowski, Julie J AU - Kumanyika, Shiriki AU - Fielding, Jonathan E AD - U.S. Department of Health and Human Services, Washington, DC, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 551 EP - 557 PB - Sage Publications, Thousand Oaks CA VL - 38 IS - 6 SN - 1090-1981, 1090-1981 KW - health disparities health policy health promotion measurement development KW - Goals KW - Social structure KW - Health KW - Public policy KW - Unity KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925740294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Healthy+People%3A+A+2020+Vision+for+the+Social+Determinants+Approach&rft.au=Koh%2C+Howard+K%3BPiotrowski%2C+Julie+J%3BKumanyika%2C+Shiriki%3BFielding%2C+Jonathan+E&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2011-01-01&rft.volume=38&rft.issue=6&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198111428646 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-03-01 N1 - Number of references - 37 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Health; Goals; Health promotion; Unity; Social structure; Public policy DO - http://dx.doi.org/10.1177/1090198111428646 ER - TY - JOUR T1 - Evaluation of anti-vibration effectiveness of glove materials using an animal model AN - 920800856; 16170356 AB - Gloves with anti-vibration features are increasingly used to reduce impact vibrations or shocks transmitted to the hands of power tool operators. Selection and evaluation of the glove materials are important steps in the designs of such gloves. In the current study, we proposed an approach to objectively evaluate the effectiveness of the glove materials using a rat-tail impact model. As a critical part of a systematic investigation, we examined the vibration reduction characteristics of typical resilient glove materials (air bladders and viscoelastic gels) and the impact vibrations transmitted to the rat tail. A special test platform that mimics impact tool vibrations was constructed and used in the experiment. A scanning laser vibrometer was used to measure the vibration at points across the platform surface under several different test conditions. The peak acceleration was found to be greatly attenuated by the glove materials, especially by using strips from a gel-filled glove. The rat tail was found to effectively absorb the high-frequency vibration. However, the glove materials and the rat tail did not reduce the frequency-weighted acceleration. The implications of the experimental results are discussed. JF - Bio-Medical Materials and Engineering AU - Xu, Xueyan S AU - Riley, Danny A AU - Persson, Magnus AU - Welcome, Daniel E AU - Krajnak, Kristine AU - Wu, John Z AU - Govinda Raju, Sandya R AU - Dong, Ren G AD - National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 193 EP - 211 PB - IOS Press, 5795-G Burke Centre Pkwy Burke VA 22015 United States VL - 21 IS - 4 SN - 0959-2989, 0959-2989 KW - Biotechnology and Bioengineering Abstracts KW - Handarm vibration KW - animal model KW - rat-tail model KW - anti-vibration gloves KW - handarm vibration syndrome KW - Vibrations KW - Gels KW - Shock KW - Tails KW - Animal models KW - Gloves KW - Hand KW - viscoelasticity KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920800856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bio-Medical+Materials+and+Engineering&rft.atitle=Evaluation+of+anti-vibration+effectiveness+of+glove+materials+using+an+animal+model&rft.au=Xu%2C+Xueyan+S%3BRiley%2C+Danny+A%3BPersson%2C+Magnus%3BWelcome%2C+Daniel+E%3BKrajnak%2C+Kristine%3BWu%2C+John+Z%3BGovinda+Raju%2C+Sandya+R%3BDong%2C+Ren+G&rft.aulast=Xu&rft.aufirst=Xueyan&rft.date=2011-01-01&rft.volume=21&rft.issue=4&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Bio-Medical+Materials+and+Engineering&rft.issn=09592989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Gels; Vibrations; Shock; Tails; Animal models; Hand; Gloves; viscoelasticity ER - TY - JOUR T1 - Response to 'Exposure science will not increase protection of workers from asbestos-caused diseases: NIOSH fails to provide needed public health action and leadership' AN - 920787305; 14164394 JF - Journal of Exposure Science and Environmental Epidemiology AU - Howard, John AU - Middendorf, Paul AD - CDC/NIOSH, Washington, D.C., USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 116 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 21 IS - 1 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Occupational exposure KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920787305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Response+to+%27Exposure+science+will+not+increase+protection+of+workers+from+asbestos-caused+diseases%3A+NIOSH+fails+to+provide+needed+public+health+action+and+leadership%27&rft.au=Howard%2C+John%3BMiddendorf%2C+Paul&rft.aulast=Howard&rft.aufirst=John&rft.date=2011-01-01&rft.volume=21&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2010.54 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Occupational exposure; Public health DO - http://dx.doi.org/10.1038/jes.2010.54 ER - TY - JOUR T1 - Personality Traits Prospectively Predict Verbal Fluency in a Lifespan Sample AN - 919970062; 201203130 AB - In a community-dwelling sample (N = 4,790; age range 14-94), we examined whether personality traits prospectively predicted performance on a verbal fluency task. Open, extraverted, and emotionally stable participants had better verbal fluency. At the facet level, dispositionally happy and self-disciplined participants retrieved more words; those prone to anxiety and depression and those who were deliberative retrieved fewer words. Education moderated the association between conscientiousness and fluency such that participants with lower education performed better on the fluency task if they were also conscientious. Age was not a moderator at the domain level, indicating that the personality-fluency associations were consistent across the life span. A disposition toward emotional vulnerability and being less open, less happy, and undisciplined may be detrimental to cognitive performance. [Copyright American Psychological Association] JF - Psychology and Aging AU - Sutin, Angelina R AU - Terracciano, Antonio AU - Kitner-Triolo, Melissa H AU - Uda, Manuela AU - Schlessinger, David AU - Zonderman, Alan B AD - Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland sutina@mail.nih.gov Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 994 EP - 999 PB - American Psychological Association, Washington DC VL - 26 IS - 4 SN - 0882-7974, 0882-7974 KW - Task performance KW - Life span KW - Personality KW - Moderators KW - Anxiety-Depression KW - Fluency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919970062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Personality+Traits+Prospectively+Predict+Verbal+Fluency+in+a+Lifespan+Sample&rft.au=Sutin%2C+Angelina+R%3BTerracciano%2C+Antonio%3BKitner-Triolo%2C+Melissa+H%3BUda%2C+Manuela%3BSchlessinger%2C+David%3BZonderman%2C+Alan+B&rft.aulast=Sutin&rft.aufirst=Angelina&rft.date=2011-01-01&rft.volume=26&rft.issue=4&rft.spage=994&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2Fa0024276 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Fluency; Life span; Task performance; Personality; Anxiety-Depression; Moderators DO - http://dx.doi.org/10.1037/a0024276 ER - TY - JOUR T1 - Workplace and individual risk factors for carpal tunnel syndrome AN - 911155398; 16059758 AB - OBJECTIVES: To quantify the relationship between workplace physical factors, particularly hand activity level (HAL) and forceful exertion and carpal tunnel syndrome (CTS), while taking into account individual factors. To compare quantitative exposure assessment measures with more practical ratings-based measures. METHODS: In a group of healthcare and manufacturing workers, each study participant's job tasks were evaluated for HAL, forceful exertion and other physical stressors and videotaped for further analysis, including frequency and duration of exertion and postural deviation. Electrodiagnostic testing of median and ulnar nerves and questionnaires were administered to all participants. A CTS case required median mononeuropathy and symptoms on hand diagrams in fingers 1-3. Multiple logistic regression models were used to analyse associations between job and individual factors and CTS. RESULTS: Of 477 workers studied, 57 (11.9%) were dominant hand CTS cases. Peak force greater than or equal to 70% maximum voluntary contraction versus <20% maximum voluntary contraction resulted in an OR of 2.74 (1.32-5.68) for CTS. Among those with a body mass index greater than or equal to 30, the OR for greater than or equal to 15 exertions per minute was 3.35 (1.14-9.87). Peak worker ratings of perceived exertion increased the odds for CTS by 1.14 (1.01-1.29) for each unit increase on the 10-point scale. The odds for CTS increased by 1.38 (1.05-1.81) for each unit increase on the HAL 10-point scale among men, but not women. Combined force and HAL values above the ACGIH TLV for HAL resulted in an OR of 2.96 (1.51-5.80) for CTS. DISCUSSION/CONCLUSIONS: Quantitative and ratings-based job exposure measures were each associated with CTS. Obesity increased the association between frequency of exertion and CTS. JF - Occupational and Environmental Medicine AU - Burt, Susan AU - Crombie, Ken AU - Jin, Yan AU - Wurzelbacher, Steve AU - Ramsey, Jessica AU - Deddens, James AD - Industrywide Studies Branch, Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 928 EP - 933 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 IS - 12 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health care KW - Perception KW - body mass KW - Risk factors KW - carpal tunnel syndrome KW - overuse injuries KW - obesity KW - Occupational exposure KW - posture KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Workplace+and+individual+risk+factors+for+carpal+tunnel+syndrome&rft.au=Burt%2C+Susan%3BCrombie%2C+Ken%3BJin%2C+Yan%3BWurzelbacher%2C+Steve%3BRamsey%2C+Jessica%3BDeddens%2C+James&rft.aulast=Burt&rft.aufirst=Susan&rft.date=2011-01-01&rft.volume=68&rft.issue=12&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Health care; body mass; Perception; Risk factors; overuse injuries; carpal tunnel syndrome; obesity; Occupational exposure; posture ER - TY - JOUR T1 - Assessing exposures to cleaning and disinfecting chemicals for an epidemiologic study of asthma in healthcare occupations AN - 911150841; 15940098 AB - OBJECTIVES: Cleaning and disinfectant products have been identified as important risk factors for asthma, and are used extensively in healthcare; however, quantitative exposure measurements of these etiologic agents are not well characterised. The objective of this study was to quantitatively characterise exposure to cleaning and disinfecting compounds, or their surrogates, and to develop a job/task-exposure matrix (J/TEM) for an epidemiologic study of asthma in healthcare occupations. METHODS: Exposure assessments were conducted at four hospitals targeting six healthcare occupations: nursing/nursing aides, respiratory therapists, dental assistants/technicians, medical and clinical laboratory technicians, housekeepers, and disinfecting and sterilising technicians. Area and personal air monitoring was conducted for time-integrated volatile organic compounds (VOCs) and continuous measurements of total VOCs. Tasks performed, products used, manner of application, tools, controls and personal protective equipment use were logged in a task diary at 5-min intervals. A range of VOCs were quantified including chlorinated hydrocarbons, ketones, terpenes, acrylics, alcohols, aromatic and aliphatic hydrocarbons, most of which were in the 1 to 10 parts-per-billion range except for alcohols and m,p-xylene (parts-per-million concentrations). RESULTS: The chemical agents and levels varied by occupation and form the basis for developing an asthma-specific J/TEM for healthcare occupations. The jobs/tasks form the job axis while the chemicals/classes of chemicals form the exposure axis with measured concentrations as cells of the J/TEM. CONCLUSIONS: These results will be incorporated into a survey questionnaire to elicit worker-specific information on jobs, tasks, and products used, and together, will be used to develop exposure estimates for the epidemiologic study participants. JF - Occupational and Environmental Medicine AU - Virji, Mohammed Abbas AU - LeBouf, Ryan AU - Saito, Rena AU - Stefaniak, Aleksandr AU - Stanton, Marcia AU - Henneberger, Paul AD - NIOSH Division of Respiratory Disease Studies, Morgantown, USA Y1 - 2011 PY - 2011 DA - 2011 SP - A79 EP - A80 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 68 SN - 1351-0711, 1351-0711 KW - Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Alcohol KW - Pollution monitoring KW - Health care KW - Asthma KW - Respiratory diseases KW - technicians KW - aromatic hydrocarbons KW - Hospitals KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911150841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Assessing+exposures+to+cleaning+and+disinfecting+chemicals+for+an+epidemiologic+study+of+asthma+in+healthcare+occupations&rft.au=Virji%2C+Mohammed+Abbas%3BLeBouf%2C+Ryan%3BSaito%2C+Rena%3BStefaniak%2C+Aleksandr%3BStanton%2C+Marcia%3BHenneberger%2C+Paul&rft.aulast=Virji&rft.aufirst=Mohammed&rft.date=2011-01-01&rft.volume=68&rft.issue=&rft.spage=A79&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Chemicals; Pollution monitoring; Alcohol; Health care; Asthma; Respiratory diseases; technicians; aromatic hydrocarbons; Hospitals ER - TY - JOUR T1 - Genetic Susceptibility and the Setting of Occupational Health Standards AN - 910644647; 15412495 AB - As more is learned about genetic susceptibility to occupational and environmental hazards, there will be increasing pressure to use genetic susceptibility information in setting occupational health standards. Historically, this has not been done, but a growing body of research assesses inherited genetic factors as modifiers of the effects of hazardous exposures. Additionally, acquired genetic and epigenetic characteristics could also be used in standard setting. However, for both inherited and acquired genetic characteristics, many scientific, ethical, legal, and social issues could arise. Investigators need to examine the potential role and implications of using genetic information in standard setting. In this review, we focus primarily on inherited genetic factors and their role in occupational health standard setting. JF - Annual Review of Public Health AU - Schulte, P AU - Howard, J AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA, pschulte@cdc.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 149 EP - 159 VL - 32 SN - 0163-7525, 0163-7525 KW - Genetics Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Genetic factors KW - environmental hazards KW - Public health KW - epigenetics KW - Reviews KW - Ethics KW - Pressure KW - Occupational health KW - G 07880:Human Genetics KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910644647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Public+Health&rft.atitle=Genetic+Susceptibility+and+the+Setting+of+Occupational+Health+Standards&rft.au=Schulte%2C+P%3BHoward%2C+J&rft.aulast=Schulte&rft.aufirst=P&rft.date=2011-01-01&rft.volume=32&rft.issue=&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Public+Health&rft.issn=01637525&rft_id=info:doi/10.1146%2Fannurev-publhealth-031210-101144 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genetic factors; epigenetics; Ethics; Reviews; Pressure; Public health; Historical account; environmental hazards; Occupational health DO - http://dx.doi.org/10.1146/annurev-publhealth-031210-101144 ER - TY - JOUR T1 - Wireless Medical Systems Risks, Challenges, And Opportunities AN - 907175650; 16061687 AB - Envision a wireless patient monitoring system at a large busy hospital suddenly loses connection with several patients. The staff scrambles to reconnect the patients to wired monitors while the clinical engineering department tries to figure out the problem. The cause is traced to the new digital television broadcast which has completely overwhelmed the medical system. super(1) Consider drug infusion pumps, active implant-able medical devices, wireless nurse call units, or blood collection systems where the wireless link is slowed, intermittent, disrupted, or cannot be reliably established. Visualize a patient just home from a procedure where a new pacemaker generator was implanted because the old device battery was at the end of its life. He is awakened by an alarm that indicates battery end of life only to find that the alarm was from the old pacemaker that the patient had placed near his bed. super(2) These are real events. JF - Biomedical Instrumentation & Technology AU - Witters, D AD - Office of Science and Engineering Laboratories, CDRH at the U.S. Food and Drug Administration, USA, donald.witters@fda.hhs.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 49 EP - 52 PB - Association for the Advancement of Medical Instrumentation SN - 0899-8205, 0899-8205 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Vocalization behavior KW - Pacemakers KW - Drugs KW - Hospitals KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907175650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Instrumentation+%26+Technology&rft.atitle=Wireless+Medical+Systems+Risks%2C+Challenges%2C+And+Opportunities&rft.au=Witters%2C+D&rft.aulast=Witters&rft.aufirst=D&rft.date=2011-01-01&rft.volume=&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Biomedical+Instrumentation+%26+Technology&rft.issn=08998205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Blood; Vocalization behavior; Pacemakers; Drugs; Hospitals ER - TY - JOUR T1 - Job Satisfaction, Common Cold, and Sickness Absence among White-collar Employees: A Cross-sectional Survey AN - 907162327; 14508991 AB - The purpose of this study is to examine the independent association of job satisfaction with common cold and sickness absence among Japanese workers. A total of 307 apparently healthy white-collar employees (165 men and 142 women), aged 22-69 (mean 36) yr, completed a questionnaire survey during April to June, 2002. Global job satisfaction was measured by a 4-item scale from the Japanese version of a generic job stress questionnaire with higher scores indicating greater satisfaction. Information about whether the employees had a common cold (within the past 6 months) and sickness absence (within the past 12 months) was self-reported. Hierarchical log-linear Poisson regression analysis controlling for confounders revealed that greater job satisfaction was inversely correlated with days (B=-0.116; p-0.001) and times (B=-0.058; p=0.067) of common cold and days (B=-0.160; p-0.001) and times (B=-0.141; p-0.001) of sickness absence. Our findings suggested that poor job satisfaction is associated with both common cold and sickness absence. JF - Industrial Health AU - Nakata, Akinori AU - Takahashi, Masaya AU - Irie, Masahiro AU - Ray, Tapas AU - Swanson, Naomi G AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health Y1 - 2011 PY - 2011 DA - 2011 SP - 116 EP - 121 PB - National Institute of Industrial Health. Japan., 21-1 Nagao 6-chome Kawasaki-shi 214-0023 Kanagawa-ken Japan VL - 49 IS - 1 SN - 1880-8026, 1880-8026 KW - Physical Education Index; Health & Safety Science Abstracts KW - Analysis KW - Employees KW - Employment KW - Health KW - Illness KW - Occupational health KW - Satisfaction KW - Surveys KW - Women KW - Japan UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907162327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Job+Satisfaction%2C+Common+Cold%2C+and+Sickness+Absence+among+White-collar+Employees%3A+A+Cross-sectional+Survey&rft.au=Nakata%2C+Akinori%3BTakahashi%2C+Masaya%3BIrie%2C+Masahiro%3BRay%2C+Tapas%3BSwanson%2C+Naomi+G&rft.aulast=Nakata&rft.aufirst=Akinori&rft.date=2011-01-01&rft.volume=49&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=18808026&rft_id=info:doi/ L2 - http://www.jstage.jst.go.jp/article/indhealth/49/1/116/_pdf LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Satisfaction; Analysis; Women; Employees; Surveys; Health; Employment; Illness; Occupational health; Japan ER - TY - JOUR T1 - Comparison of Salmonella enterica Serovar Heidelberg Isolates from Human Patients with Those from Animal and Food Sources AN - 907162069; 14452858 AB - Seventy-eight Salmonella enterica serovar Heidelberg isolates from humans were tested for antimicrobial susceptibility, resistance genes, and plasmids and genotyped by pulsed-field gel electrophoresis (PFGE). Most (88%) contained plasmids, and 47% were resistant to antimicrobials. The overall results were compared to those of previous S. Heidelberg studies of food- and animal-related sources, and multiple similarities were observed. JF - Journal of Clinical Microbiology AU - Han, Jing AU - David, Donna E AU - Deck, Joanna AU - Lynne, Aaron M AU - Kaldhone, Pravin AU - Nayak, Rajesh AU - Stefanova, Rossina AU - Foley, Steven L AD - Division of Microbiology, FDA National Center for Toxicological Research, Jefferson, Arizona 72079 Y1 - 2011 PY - 2011 DA - 2011 SP - 1130 EP - 1133 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 49 IS - 3 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Salmonella enterica KW - Food sources KW - Pulsed-field gel electrophoresis KW - Plasmids KW - Antimicrobial agents KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907162069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Comparison+of+Salmonella+enterica+Serovar+Heidelberg+Isolates+from+Human+Patients+with+Those+from+Animal+and+Food+Sources&rft.au=Han%2C+Jing%3BDavid%2C+Donna+E%3BDeck%2C+Joanna%3BLynne%2C+Aaron+M%3BKaldhone%2C+Pravin%3BNayak%2C+Rajesh%3BStefanova%2C+Rossina%3BFoley%2C+Steven+L&rft.aulast=Han&rft.aufirst=Jing&rft.date=2011-01-01&rft.volume=49&rft.issue=3&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Food sources; Pulsed-field gel electrophoresis; Plasmids; Antimicrobial agents; Salmonella enterica ER - TY - JOUR T1 - Continuing Education Course #3: Current Practices and Future Trends in Neuropathology Assessment for Developmental Neurotoxicity Testing AN - 907159002; 14454640 AB - The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and noninvasive imaging, and facilitate a discussion among experienced neuropathologists and regulatory scientists regarding suitable DNT practices. Conventional DNT neuropathology endpoints are qualitative histopathology and morphometric endpoints of particularly vulnerable sites (e.g., cerebral, cerebellar, or hippocampal thickness). Novel imaging and stereology measurements hold promise for automated analysis of factors that cannot be effectively examined in routinely processed specimens (e.g., cell numbers, fiber tract integrity). The panel recommended that dedicated DNT neuropathology data sets be acquired on a minimum of 8 sections (for qualitative assessment) or 3 sections (for quantitative linear and stereological analyses) using a small battery of stains to examine neurons and myelin. Where guidelines permit discretion, immersion fixation is acceptable for younger animals (postnatal day 22 or earlier), and peripheral nerves may be embedded in paraffin. Frequent concerns regarding DNT data sets include false-negative outcomes due to processing difficulties (e.g., lack of concordance among sections from different animals) and insensitive analytical endpoints (e.g., qualitative evaluation) as well as false-positive results arising from overinterpretation or misreading by inexperienced pathologists. JF - Toxicologic Pathology AU - Bolon, Brad AU - Garman, Robert H AU - Gundersen, Hans Joergen G AU - Allan Johnson, G AU - Kaufmann, Wolfgang AU - Krinke, Georg AU - Little, Peter B AU - Makris, Susan L AU - Mellon, RDaniel AU - Sulik, Kathleen K AU - Jensen, Karl AD - GEMpath Inc., Longmont, Colorado. Consultants in Veterinary Pathology, Murrysville, Pennsylvania. University of Aarhus, DK-8000 Aarhus, Denmark. Duke University, Durham, North Carolina. BASF, Ludwigshafen, Germany. Frenkendorf CH-4402, Switzerland. Charles River Laboratories Inc., Durham, North Carolina. U.S. Environmental Protection Agency (EPA), Washington, DC. U.S. Food and Drug Administration (FDA), Silver Spring, Maryland. University of North Carolina, Chapel Hill, North Carolina. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Current address, Merck KGaA, 64293 Darmstadt, Germany Y1 - 2011 PY - 2011 DA - 2011 SP - 289 EP - 293 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 39 IS - 1 SN - 0192-6233, 0192-6233 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Cell number KW - Cerebellum KW - Data processing KW - Fibers KW - Hippocampus KW - Immersion KW - Misreading KW - Myelin KW - Neurons KW - Neuropathology KW - Neurotoxicity KW - Paraffin KW - Peripheral nerves KW - Stains KW - N3 11027:Neurology & neuropathology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907159002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Continuing+Education+Course+%233%3A+Current+Practices+and+Future+Trends+in+Neuropathology+Assessment+for+Developmental+Neurotoxicity+Testing&rft.au=Bolon%2C+Brad%3BGarman%2C+Robert+H%3BGundersen%2C+Hans+Joergen+G%3BAllan+Johnson%2C+G%3BKaufmann%2C+Wolfgang%3BKrinke%2C+Georg%3BLittle%2C+Peter+B%3BMakris%2C+Susan+L%3BMellon%2C+RDaniel%3BSulik%2C+Kathleen+K%3BJensen%2C+Karl&rft.aulast=Bolon&rft.aufirst=Brad&rft.date=2011-01-01&rft.volume=39&rft.issue=1&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Paraffin; Data processing; Myelin; Cell number; Hippocampus; Cerebellum; Stains; Fibers; Neurons; Neurotoxicity; Immersion; Misreading; Neuropathology; Peripheral nerves ER - TY - JOUR T1 - A Proteomic and Transcriptomic Approach Reveals New Insight into beta -methylthiolation of Escherichia coli Ribosomal Protein S12 AN - 907157444; 14453172 AB - beta -methylthiolation is a novel post-translational modification mapping to a universally conserved Asp 88 of the bacterial ribosomal protein S12. This S12 specific modification has been identified on orthologs from multiple bacterial species. The origin and functional significance was investigated with both a proteomic strategy to identify candidate S12 interactors and expression microarrays to search for phenotypes that result from targeted gene knockouts of select candidates. Utilizing an endogenous recombinant E. coli S12 protein with an affinity tag as bait, mass spectrometric analysis identified candidate S12 binding partners including RimO (previously shown to be required for this post-translational modification) and YcaO, a conserved protein of unknown function. Transcriptomic analysis of bacterial strains with deleted genes for RimO and YcaO identified an overlapping transcriptional phenotype suggesting that YcaO and RimO likely share a common function. As a follow up, quantitative mass spectrometry additionally indicated that both proteins dramatically impacted the modification status of S12. Collectively, these results indicate that the YcaO protein is involved in beta -methylthiolation of S12 and its absence impairs the ability of RimO to modify S12. Additionally, the proteomic data from this study provides direct evidence that the E. coli specific beta -methylthiolation likely occurs when S12 is assembled as part of a ribosomal subunit. JF - Molecular and Cellular Proteomics AU - Strader, Michael Brad AU - Costantino, Nina AU - Elkins, Christopher A AU - Chen, Cai Yun AU - Patel, Isha AU - Makusky, Anthony J AU - Choy, John S AU - Court, Donald L AU - Markey, Sanford P AU - Kowalak, Jeffrey A AD - From the Laboratory of Neurotoxicology, National Institute of Mental Health, Bethesda, MD 20892, USA. National Cancer Institute/Frederick Cancer Research and Development Center, Frederick, MD 21702, USA. U.S. Food and Drug Administration, Laurel MD 20708, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - M110.005199 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 10 IS - 3 SN - 1535-9476, 1535-9476 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - DNA microarrays KW - Data processing KW - Mass spectroscopy KW - Peptide mapping KW - Post-translation KW - Ribosomal subunits KW - Transcription KW - proteomics KW - ribosomal protein S12 KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907157444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Proteomics&rft.atitle=A+Proteomic+and+Transcriptomic+Approach+Reveals+New+Insight+into+beta+-methylthiolation+of+Escherichia+coli+Ribosomal+Protein+S12&rft.au=Strader%2C+Michael+Brad%3BCostantino%2C+Nina%3BElkins%2C+Christopher+A%3BChen%2C+Cai+Yun%3BPatel%2C+Isha%3BMakusky%2C+Anthony+J%3BChoy%2C+John+S%3BCourt%2C+Donald+L%3BMarkey%2C+Sanford+P%3BKowalak%2C+Jeffrey+A&rft.aulast=Strader&rft.aufirst=Michael&rft.date=2011-01-01&rft.volume=10&rft.issue=3&rft.spage=M110.005199&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Data processing; ribosomal protein S12; Peptide mapping; Post-translation; Transcription; Ribosomal subunits; proteomics; DNA microarrays; Mass spectroscopy; Escherichia coli ER - TY - JOUR T1 - Induction of cell death after localization to the host cell mitochondria by the Mycobacterium tuberculosis PE_PGRS33 protein AN - 907155267; 14453205 AB - PE_PGRS33 is the most studied member of the unique PE family of mycobacterial proteins. These proteins are composed of a PE domain (Pro-Glu motif), a linker region and a PGRS domain (polymorphic GC-rich-repetitive sequence). Previous studies have shown that PE_PGRS33 is surface-exposed, constitutively expressed during growth and infection, involved in creating antigenic diversity, and able to induce death in transfected or infected eukaryotic cells. In this study, we showed that PE_PGRS33 co-localizes to the mitochondria of transfected cells, a phenomenon dependent on the linker region and the PGRS domain, but not the PE domain. Using different genetic fusions and chimeras, we also demonstrated a direct correlation between localization to the host mitochondria and the induction of cell death. Finally, although all constructs localizing to the mitochondria did induce apoptosis, only the wild-type PE_PGRS33 with its own PE domain also induced primary necrosis, indicating a potentially important role for the PE domain. Considering the importance of primary necrosis in Mycobacterium tuberculosis dissemination during natural infection, the PE_PGRS33 protein may play a crucial role in the pathogenesis of tuberculosis. JF - Microbiology AU - Cadieux, Nathalie AU - Parra, Marcela AU - Cohen, Hannah AU - Maric, Dragan AU - Morris, Sheldon L AU - Brennan, Michael J AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 793 EP - 804 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Reading RG7 1AG UK VL - 157 SN - 1350-0872, 1350-0872 KW - Microbiology Abstracts B: Bacteriology KW - Chimeras KW - Necrosis KW - Apoptosis KW - Mitochondria KW - Tuberculosis KW - Infection KW - Mycobacterium tuberculosis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907155267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology&rft.atitle=Induction+of+cell+death+after+localization+to+the+host+cell+mitochondria+by+the+Mycobacterium+tuberculosis+PE_PGRS33+protein&rft.au=Cadieux%2C+Nathalie%3BParra%2C+Marcela%3BCohen%2C+Hannah%3BMaric%2C+Dragan%3BMorris%2C+Sheldon+L%3BBrennan%2C+Michael+J&rft.aulast=Cadieux&rft.aufirst=Nathalie&rft.date=2011-01-01&rft.volume=157&rft.issue=&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Microbiology&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Chimeras; Necrosis; Apoptosis; Mitochondria; Tuberculosis; Infection; Mycobacterium tuberculosis ER - TY - JOUR T1 - Molecular Correlates of Experimental Cerebral Malaria Detectable in Whole Blood AN - 907151692; 14387344 AB - Cerebral malaria (CM) is a primary cause of deaths caused by Plasmodium falciparum in young children in sub-Saharan Africa. Laboratory tests based on early detection of host biomarkers in patient blood would help in the prognosis and differential diagnosis of CM. Using the Plasmodium berghei ANKA murine model of experimental cerebral malaria (ECM), we have identified over 300 putative diagnostic biomarkers of ECM in the circulation by comparing the whole-blood transcriptional profiles of resistant mice (BALB/c) to those of two susceptible strains (C57BL/6 and CBA/CaJ). Our results suggest that the transcriptional profile of whole blood captures the molecular and immunological events associated with the pathogenesis of disease. We find that during ECM, erythropoiesis is dysfunctional, thrombocytopenia is evident, and glycosylation of cell surface components may be modified. Furthermore, analysis of immunity-related genes suggests that slightly distinct mechanisms of immunopathogenesis may operate in susceptible C57BL/6 and CBA/CaJ mice. Furthermore, our data set has allowed us to create a molecular signature of ECM composed of a subset of circulatory markers. Complement component C1q, beta -chain, nonspecific cytotoxic cell receptor protein 1, prostate stem cell antigen, DnaJC, member 15, glutathione S-transferase omega-1, and thymidine kinase 1 were overexpressed in blood during the symptomatic phase of ECM, as measured by quantitative real-time PCR analysis. These studies provide the first host transcriptome database that is uniquely altered during the pathogenesis of ECM in blood. A subset of these mediators of ECM warrant validation in P. falciparum-infected young African children as diagnostic markers of CM. JF - Infection and Immunity AU - Oakley, Miranda S AU - Anantharaman, Vivek AU - Venancio, Thiago M AU - Zheng, Hong AU - Mahajan, Babita AU - Majam, Victoria AU - McCutchan, Thomas F AU - Myers, Timothy G AU - Aravind, L AU - Kumar, Sanjai AD - Division of Bacterial, Parasitic, and Allergenic Products Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1244 EP - 1253 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 79 IS - 3 SN - 0019-9567, 0019-9567 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; CSA Neurosciences Abstracts; Immunology Abstracts KW - Cell surface KW - Parasites KW - Human diseases KW - Erythropoiesis KW - Nucleotide sequence KW - Animal models KW - Thymidine kinase KW - Malaria KW - Glycosylation KW - Biomarkers KW - Hosts KW - Glutathione transferase KW - Public health KW - Gene expression KW - Stem cells KW - Thrombocytopenia KW - Antigens KW - Polymerase chain reaction KW - Data processing KW - Complement component C1q KW - Prognosis KW - Transcription KW - Immunopathogenesis KW - Plasmodium falciparum KW - Children KW - biomarkers KW - Plasmodium berghei KW - Databases KW - Blood KW - Cytotoxicity KW - Differential diagnosis KW - Extracellular matrix KW - Africa KW - Prostate KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907151692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Molecular+Correlates+of+Experimental+Cerebral+Malaria+Detectable+in+Whole+Blood&rft.au=Oakley%2C+Miranda+S%3BAnantharaman%2C+Vivek%3BVenancio%2C+Thiago+M%3BZheng%2C+Hong%3BMahajan%2C+Babita%3BMajam%2C+Victoria%3BMcCutchan%2C+Thomas+F%3BMyers%2C+Timothy+G%3BAravind%2C+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2011-01-01&rft.volume=79&rft.issue=3&rft.spage=1244&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Parasites; Blood; Human diseases; Antigens; Nucleotide sequence; Malaria; Hosts; Biomarkers; Public health; Cell surface; Data processing; Erythropoiesis; Complement component C1q; Animal models; Prognosis; Immunopathogenesis; Transcription; Thymidine kinase; Glycosylation; Children; Glutathione transferase; biomarkers; Gene expression; Databases; Stem cells; Cytotoxicity; Differential diagnosis; Thrombocytopenia; Extracellular matrix; Polymerase chain reaction; Prostate; Plasmodium falciparum; Plasmodium berghei; Africa ER - TY - JOUR T1 - Cohort mortality study of workers at seven beryllium processing plants: update and associations with cumulative and maximum exposure AN - 904476597; 14658969 AB - OBJECTIVES: To extend follow-up of cause-specific mortality in workers at seven beryllium processing plants and to estimate associations between mortality risk and beryllium exposure. METHODS: 9199 workers were followed for mortality from 1940 through 2005. Standardised mortality ratios (SMRs) were estimated based on US population comparisons for lung, nervous system and urinary tract cancers, chronic obstructive pulmonary disease (COPD), chronic kidney disease, and categories containing chronic beryllium disease (CBD) and cor pulmonale. Associations with maximum and cumulative exposure were calculated for a subset of the workers. RESULTS: Overall mortality in the cohort compared with the US population was elevated for lung cancer (SMR 1.17; 95% CI 1.08 to 1.28), COPD (SMR 1.23; 95% CI 1.13 to 1.32), and the categories containing CBD (SMR 7.80; 95% CI 6.26 to 9.60) and cor pulmonale (SMR 1.17; 95% CI 1.08 to 1.26). Mortality rates for most diseases of interest increased with time-since-hire. For the category including CBD, rates were substantially elevated compared to the US population across all exposure groups. Workers whose maximum beryllium exposure was greater than or equal to 10 mu g/m3 had higher rates of lung cancer, urinary tract cancer, COPD and the category containing cor pulmonale than workers with lower exposure. Significant positive trends with cumulative exposure were observed for nervous system cancers (p=0.0006) and, when short-term workers were excluded, lung cancer (p=0.01), urinary tract cancer (p=0.003) and COPD (p<0.0001). CONCLUSION: These findings reaffirm that lung cancer and CBD, and suggest that COPD and nervous system and urinary tract cancers, are related to beryllium exposure. Cigarette smoking and exposure to other lung carcinogens are unlikely to explain these elevations. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary K AU - Couch, James R AU - Petersen, Martin R AU - Carreon, Tania AU - Jin, Yan AU - Deddens, James A AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 345 EP - 353 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Cigarettes KW - Urine KW - Beryllium KW - Kidney KW - Cancer KW - Occupational exposure KW - Lung cancer KW - chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904476597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Cohort+mortality+study+of+workers+at+seven+beryllium+processing+plants%3A+update+and+associations+with+cumulative+and+maximum+exposure&rft.au=Schubauer-Berigan%2C+Mary+K%3BCouch%2C+James+R%3BPetersen%2C+Martin+R%3BCarreon%2C+Tania%3BJin%2C+Yan%3BDeddens%2C+James+A&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2011-01-01&rft.volume=68&rft.issue=5&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Mortality; Cigarettes; Urine; Beryllium; Kidney; Occupational exposure; Cancer; chronic obstructive pulmonary disease; Lung cancer ER - TY - JOUR T1 - Cost-effectiveness of Respiratory Syncytial Virus Prophylaxis in Various Indications AN - 904476290; 14956824 AB - OBJECTIVES: To evaluate the cost-effectiveness of immunoprophylaxis against respiratory syncytial virus (RSV) infections with palivizumab based on actual cost and observed incidence rates in various pediatric risk groups. DESIGN: Decision tree analysis comparing children with various combinations of the following indications: chronic lung disease, congenital heart disease, or prematurity ( less than or equal to 32 weeks gestation), and children with none of these indications. One-way sensitivity analyses and Monte Carlo simulations were used to quantify parameter uncertainty. SETTING: Florida during the 2004-2005 RSV season. PARTICIPANTS: A total of 159 790 Medicaid-eligible children aged 0 to 2 years. INTERVENTION: Palivizumab prophylaxis compared with no prophylaxis. Outcomes Measure Incremental cost (2010 US dollars) per hospitalization for RSV infection avoided. RESULTS: The mean cost of palivizumab per dose ranged from $1661 for infants younger than 6 months of age to $2584 for children in their second year of life. Among preterm infants younger than 6 months of age without other indications, immunoprophylaxis with palivizumab cost $302 103 (95% confidence interval, $141 850-$914 798) to prevent 1 RSV-related hospitalization. Given a mean cost of $8910 for 1 RSV-related hospitalization in this subgroup, palivizumab would be cost-neutral at a per-dose cost of $47. Incremental cost-effectiveness ratios for the other subgroups ranged from $361 727 to more than $1.3 million per RSV-related hospitalization avoided in children up to 2 years of age with chronic lung disease and no additional risk factors. Younger age and multiple indications were associated with improvements in the incremental cost-effectiveness ratio. CONCLUSIONS: The cost of immunoprophylaxis with palivizumab far exceeded the economic benefit of preventing hospitalizations, even in infants at highest risk for RSV infection. JF - Archives of Pediatrics & Adolescent Medicine AU - Hampp, Christian AU - Kauf, Teresa L AU - Saidi, Arwa S AU - Winterstein, Almut G AD - Author Affiliations: Office of Surveillance and Epidemiology, US Food and Drug Administration, Silver Spring, Maryland (Dr Hampp) Y1 - 2011 PY - 2011 DA - 2011 SP - 498 EP - 505 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 165 IS - 6 SN - 1072-4710, 1072-4710 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Monte Carlo simulation KW - Age KW - USA, Florida KW - Immunoprophylaxis KW - heart diseases KW - Cost-benefit analysis KW - sensitivity analysis KW - Risk factors KW - Gestation KW - Economics KW - infection KW - Risk groups KW - Heart diseases KW - Pediatrics KW - Adolescence KW - Lung diseases KW - Children KW - Respiratory syncytial virus KW - Lung KW - Prophylaxis KW - Infants KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904476290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.atitle=Cost-effectiveness+of+Respiratory+Syncytial+Virus+Prophylaxis+in+Various+Indications&rft.au=Hampp%2C+Christian%3BKauf%2C+Teresa+L%3BSaidi%2C+Arwa+S%3BWinterstein%2C+Almut+G&rft.aulast=Hampp&rft.aufirst=Christian&rft.date=2011-01-01&rft.volume=165&rft.issue=6&rft.spage=498&rft.isbn=&rft.btitle=&rft.title=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.issn=10724710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Age; Pediatrics; Immunoprophylaxis; Adolescence; Lung diseases; Children; Risk factors; Economics; Gestation; Prophylaxis; Risk groups; Infants; Heart diseases; Cost-benefit analysis; Lung; sensitivity analysis; infection; heart diseases; Respiratory syncytial virus; USA, Florida ER - TY - JOUR T1 - Associations of occupation, job control and job demands with intima-media thickness: The Multi-Ethnic Study of Atherosclerosis (MESA) AN - 904472812; 14658972 AB - OBJECTIVES: Occupation has been linked to cardiovascular disease (CVD) incidence and mortality, but few studies have investigated occupation in relation to early atherosclerotic disease. This study examined associations between various occupational characteristics and carotid artery intima-media thickness (IMT) in a multi-ethnic sample. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) recruited 6814 adults aged 45-84 years and free of clinical CVD (response rate 60%, 51% female). Questionnaire data were used to determine occupational group (managerial/professional, sales/office, service, blue-collar), psychosocial job characteristics (ie, job demands, job control) and other sociodemographic information. RESULTS: Common carotid artery (CCA)-IMT was greater for blue-collar jobs than for management/professional jobs (mean difference=0.012 mm, p=0.049) after adjustment for age, sex, race, place of birth (US or foreign born) and CVD risk factors. Compared to management/professional jobs, internal carotid artery (ICA)-IMT was greater for sales/office, service and blue-collar jobs (mean difference=0.071 mm, p<0.001; 0.057 mm, p=0.009; and 0.110 mm, p<0.001, respectively) after adjustment for age, sex, race and place of birth. The difference between blue-collar jobs and management/professional jobs remained significant after additional adjustment for CVD risk factors, income and education (mean difference=0.048 mm, p=0.045). Higher levels of control at work were associated with thinner CCA-IMT (mean difference=-0.009 mm, p=0.016, adjusted for age, sex, race and place of birth) but not with ICA-IMT. Job demands had no significant association with IMT. CONCLUSIONS: Blue-collar jobs and low levels of job control were associated with the development of subclinical atherosclerosis. JF - Occupational and Environmental Medicine AU - Fujishiro, Kaori AU - Diez Roux, Ana V AU - Landsbergis, Paul AU - Baron, Sherry AU - Barr, R Graham AU - Kaufman, Joel D AU - Polak, Joseph F AU - Stukovsky, Karen Hinckley AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 319 EP - 326 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Age KW - Education KW - mesas KW - Risk factors KW - income KW - Cardiovascular diseases KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904472812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Associations+of+occupation%2C+job+control+and+job+demands+with+intima-media+thickness%3A+The+Multi-Ethnic+Study+of+Atherosclerosis+%28MESA%29&rft.au=Fujishiro%2C+Kaori%3BDiez+Roux%2C+Ana+V%3BLandsbergis%2C+Paul%3BBaron%2C+Sherry%3BBarr%2C+R+Graham%3BKaufman%2C+Joel+D%3BPolak%2C+Joseph+F%3BStukovsky%2C+Karen+Hinckley&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2011-01-01&rft.volume=68&rft.issue=5&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; Education; Age; mesas; income; Risk factors; Cardiovascular diseases ER - TY - JOUR T1 - Urinary Biomarkers of Meat Consumption AN - 904471210; 14956992 AB - BACKGROUND: Meat intake has been positively associated with incidence and mortality of chronic diseases, including diabetes, heart disease, and several different cancers, in observational studies by using self-report methods of dietary assessment; however, these dietary assessment methods are subject to measurement error. One method to circumvent such errors is the use of biomarkers of dietary intake, but currently there are no accepted biomarkers for meat intake. METHODS: We investigated four analytes (creatinine, taurine, 1-methylhistidine, and 3-methylhistidine) specifically found in meat and excreted in urine. Twenty-four-hour urine samples were collected from 17 individuals on controlled diets containing varying levels of meat: vegetarian (0 g/d), low red meat (60 g/d), medium red meat (120 g/d), and high red meat (420 g/d), as part of two randomized crossover feeding studies. RESULTS: When compared with the low red meat diet or the vegetarian diet, the urinary levels of all four analytes were significantly higher in urine samples collected after 15 days of a high red meat diet (P < 0.0001). Only urinary 1-methylhistidine and 3-methylhistidine were statistically significantly different for every diet type, increasing as the amount of meat in the diet increased (P < 0.01 for 1-methylhistidine and P < 0.05 for 3-methylhistidine). Furthermore, urinary excretion of 1-methylhistidine and 3-methylhistidine elevated with increasing meat intake in every individual. CONCLUSION: Urinary 1-methylhistidine and 3-methylhistidine may be good biomarkers of meat intake. IMPACT: To determine the public health impact of red meat on cancer risk, biomarkers are crucial to estimate true intake; these potential biomarkers should be further investigated in free-living populations. Cancer Epidemiol Biomarkers Prev; 20(6); 1107-11. [copy ]2011 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Cross, Amanda J AU - Major, Jacqueline M AU - Sinha, Rashmi AD - Authors' Affiliations: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 1107 EP - 1111 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 6 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Cancer KW - Diets KW - Excretion KW - Feeding KW - Meat KW - Mortality KW - Public health KW - Urine KW - heart diseases KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904471210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Urinary+Biomarkers+of+Meat+Consumption&rft.au=Cross%2C+Amanda+J%3BMajor%2C+Jacqueline+M%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2011-01-01&rft.volume=20&rft.issue=6&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Meat; Diets; Bioindicators; Feeding; Mortality; Urine; meat; Excretion; heart diseases; Cancer; Public health ER - TY - JOUR T1 - A meta-analysis of leukaemia risk from protracted exposure to low-dose gamma radiation AN - 904470462; 14872860 AB - CONTEXT: More than 400 000 workers annually receive a measurable radiation dose and may be at increased risk of radiation-induced leukaemia. It is unclear whether leukaemia risk is elevated with protracted, low-dose exposure. OBJECTIVE: We conducted a meta-analysis examining the relationship between protracted low-dose ionising radiation exposure and leukaemia. DATA SOURCES: Reviews by the National Academies and United Nations provided a summary of informative studies published before 2005. PubMed and Embase databases were searched for additional occupational and environmental studies published between 2005 and 2009. STUDY SELECTION: We selected 23 studies that: (1) examined the association between protracted exposures to ionising radiation and leukaemia excluding chronic lymphocytic subtype; (2) were a cohort or nested case-control design without major bias; (3) reported quantitative estimates of exposure; and (4) conducted exposure-response analyses using relative or excess RR per unit exposure. METHODS: Studies were further screened to reduce information overlap. Random effects models were developed to summarise between-study variance and obtain an aggregate estimate of the excess RR at 100 mGy. Publication bias was assessed by trim and fill and Rosenthal's file drawer methods. RESULTS: We found an ERR at 100 mGy of 0.19 (95% CI 0.07 to 0.32) by modelling results from 10 studies and adjusting for publication bias. Between-study variance was not evident (p=0.99). CONCLUSIONS: Protracted exposure to low-dose gamma radiation is significantly associated with leukaemia. Our estimate agreed well with the leukaemia risk observed among exposed adults in the Life Span Study (LSS) of atomic bomb survivors, providing increased confidence in the current understanding of leukaemia risk from ionising radiation. However, unlike the estimates obtained from the LSS, our model provides a precise, quantitative summary of the direct estimates of excess risk from studies of protracted radiation exposures. JF - Occupational and Environmental Medicine AU - Daniels, R D AU - Schubauer-Berigan, M K AD - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), U.S. Centers for Disease Control and Prevention (CDC), USA Y1 - 2011 PY - 2011 DA - 2011 SP - 457 EP - 464 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 6 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Leukemia KW - Ionizing radiation KW - Reviews KW - Dose-response effects KW - Atomic bombs KW - life span KW - Gamma radiation KW - United Nations KW - Occupational exposure KW - R2 23020:Technological risks KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904470462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=A+meta-analysis+of+leukaemia+risk+from+protracted+exposure+to+low-dose+gamma+radiation&rft.au=Daniels%2C+R+D%3BSchubauer-Berigan%2C+M+K&rft.aulast=Daniels&rft.aufirst=R&rft.date=2011-01-01&rft.volume=68&rft.issue=6&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Leukemia; Dose-response effects; Reviews; Ionizing radiation; Atomic bombs; life span; United Nations; Gamma radiation; Occupational exposure ER - TY - JOUR T1 - Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats AN - 904470180; 14267351 AB - The intentional adulteration of pet food with melamine and derivatives, including cyanuric acid, has been implicated in the kidney failure and death of a large number of cats and dogs in the United States. Although individually these compounds present low toxicity, coexposure can lead to the formation of melamine cyanurate crystals in the nephrons and eventual kidney failure. To determine the dose-response for nephrotoxicity upon coadministration of melamine and cyanuric acid, groups of male and female F344 rats (six animals per sex per group) were fed 0 (control), 7, 23, 69, 229, or 694 ppm of both melamine and cyanuric acid; 1388 ppm melamine; or 1388 ppm cyanuric acid in the diet for 7 days. No toxicity was observed in the rats exposed to the individual compounds, whereas anorexia and a statistically significant increase in blood urea nitrogen and serum creatinine levels was observed in the animals treated with 229 and 694 ppm melamine and cyanuric acid. The kidneys of these animals were grossly enlarged and pale yellow. Large numbers of crystalline structures deposited in the tubules were seen on sections in kidneys from all rats in these treatment groups. No significant changes were detected in the remaining treatment groups exposed to both melamine and cyanuric acid. In the melamine-only treatment group, 5 of 12 rats had scattered crystals present in renal tubules when examined by wet mount. These were not observed by histopathology. The observed adverse effect level (8.6 mg/kg bw [body weight]/day) and benchmark dose modeling data (8.4-10.9 mg/kg bw/day) determined in this study suggest that the tolerable daily intake values derived from studies conducted with melamine alone may underestimate the risk from coexposures to melamine and cyanuric acid. JF - Toxicological Sciences AU - Jacob, Cristina C AU - Reimschuessel, Renate AU - Von Tungeln, Linda S AU - Olson, Greg R AU - Warbritton, Alan R AU - Hattan, David G AU - Beland, Frederick A AU - Gamboa da Costa, Goncalo AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 Y1 - 2011 PY - 2011 DA - 2011 SP - 391 EP - 397 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 119 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Blood KW - Cyanuric acid KW - X:24490 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904470180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Dose-Response+Assessment+of+Nephrotoxicity+from+a+7-Day+Combined+Exposure+to+Melamine+and+Cyanuric+Acid+in+F344+Rats&rft.au=Jacob%2C+Cristina+C%3BReimschuessel%2C+Renate%3BVon+Tungeln%2C+Linda+S%3BOlson%2C+Greg+R%3BWarbritton%2C+Alan+R%3BHattan%2C+David+G%3BBeland%2C+Frederick+A%3BGamboa+da+Costa%2C+Goncalo&rft.aulast=Jacob&rft.aufirst=Cristina&rft.date=2011-01-01&rft.volume=119&rft.issue=2&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cyanuric acid ER - TY - JOUR T1 - Dipentyl Phthalate Dosing during Sexual Differentiation Disrupts Fetal Testis Function and Postnatal Development of the Male Sprague-Dawley Rat with Greater Relative Potency than Other Phthalates AN - 904470153; 14406843 AB - Phthalate esters (PEs) constitute a large class of plasticizer compounds that are widely used for many consumer product applications. Ten or more members of the PE class of compounds are known to induce male fetal endocrine toxicity and postnatal reproductive malformations by disrupting androgen production during the sexual differentiation period of development. An early study conducted in the rat pubertal model suggested that dipentyl phthalate (DPeP) may be a more potent testicular toxicant than some more extensively studied phthalates. Regulatory agencies require dose-response and potency data to facilitate risk assessment; however, very little data are currently available for DPeP. The goal of this study was to establish a more comprehensive data set for DPeP, focusing on dose-response and potency information for fetal and postnatal male reproductive endpoints. We dosed pregnant rats on gestational day (GD) 17 or GD 14-18 and subsequently evaluated fetal testicular testosterone (T) production on GD 17.5 and GD 18, respectively. We also dosed pregnant rats on GD 8-18 and evaluated early postnatal endpoints in male offspring. Comparison of these data to data previously obtained under similar conditions for di (2-ethylhexyl) phthalate indicates that DPeP is approximately eightfold more potent in reducing fetal T production and two- to threefold more potent in inducing development of early postnatal male reproductive malformations. Additionally, fetal testicular T production was more sensitive to inhibitory effects of DPeP exposure than was gene expression of target genes involved in male reproductive development, supporting the use of this endpoint as a critical effect in the risk assessment process. JF - Toxicological Sciences AU - Hannas, Bethany R AU - Furr, Johnathan AU - Lambright, Christy S AU - Wilson, Vickie S AU - Foster, Paul MD AU - Gray, LEarl AD - National Research Council Fellowship Program. Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Y1 - 2011 PY - 2011 DA - 2011 SP - 184 EP - 193 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 120 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Androgens KW - Fetuses KW - X:24350 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904470153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Dipentyl+Phthalate+Dosing+during+Sexual+Differentiation+Disrupts+Fetal+Testis+Function+and+Postnatal+Development+of+the+Male+Sprague-Dawley+Rat+with+Greater+Relative+Potency+than+Other+Phthalates&rft.au=Hannas%2C+Bethany+R%3BFurr%2C+Johnathan%3BLambright%2C+Christy+S%3BWilson%2C+Vickie+S%3BFoster%2C+Paul+MD%3BGray%2C+LEarl&rft.aulast=Hannas&rft.aufirst=Bethany&rft.date=2011-01-01&rft.volume=120&rft.issue=1&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Fetuses ER - TY - JOUR T1 - Development of retrospective quantitative and qualitative job-exposure matrices for exposures at a beryllium processing facility AN - 904469628; 14658966 AB - OBJECTIVES: To construct a job-exposure matrix (JEM) for an Ohio beryllium processing facility between 1953 and 2006 and to evaluate temporal changes in airborne beryllium exposures. METHODS: Quantitative area- and breathing-zone-based exposure measurements of airborne beryllium were made between 1953 and 2006 and used by plant personnel to estimate daily weighted average (DWA) exposure concentrations for sampled departments and operations. These DWA measurements were used to create a JEM with 18 exposure metrics, which was linked to the plant cohort consisting of 18 568 unique job, department and year combinations. The exposure metrics ranged from quantitative metrics (annual arithmetic/geometric average DWA exposures, maximum DWA and peak exposures) to descriptive qualitative metrics (chemical beryllium species and physical form) to qualitative assignment of exposure to other risk factors (yes/no). Twelve collapsed job titles with long-term consistent industrial hygiene samples were evaluated using regression analysis for time trends in DWA estimates. RESULTS: Annual arithmetic mean DWA estimates (overall plant-wide exposures including administration, non-production, and production estimates) for the data by decade ranged from a high of 1.39 mu g/m3 in the 1950s to a low of 0.33 mu g/m3 in the 2000s. Of the 12 jobs evaluated for temporal trend, the average arithmetic DWA mean was 2.46 mu g/m3 and the average geometric mean DWA was 1.53 mu g/m3. After the DWA calculations were log-transformed, 11 of the 12 had a statistically significant (p<0.05) decrease in reported exposure over time. CONCLUSIONS: The constructed JEM successfully differentiated beryllium exposures across jobs and over time. This is the only quantitative JEM containing exposure estimates (average and peak) for the entire plant history. JF - Occupational and Environmental Medicine AU - Couch, James R AU - Petersen, Martin AU - Rice, Carol AU - Schubauer-Berigan, Mary K AD - Division of Surveillance, Hazard Evaluations, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 361 EP - 365 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Risk factors KW - Beryllium KW - USA, Ohio KW - Hygiene KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904469628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Development+of+retrospective+quantitative+and+qualitative+job-exposure+matrices+for+exposures+at+a+beryllium+processing+facility&rft.au=Couch%2C+James+R%3BPetersen%2C+Martin%3BRice%2C+Carol%3BSchubauer-Berigan%2C+Mary+K&rft.aulast=Couch&rft.aufirst=James&rft.date=2011-01-01&rft.volume=68&rft.issue=5&rft.spage=361&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Historical account; Risk factors; Beryllium; Hygiene; USA, Ohio ER - TY - JOUR T1 - Risk of lung cancer associated with quantitative beryllium exposure metrics within an occupational cohort AN - 904469626; 14658965 AB - OBJECTIVES: Beryllium has been identified as a human carcinogen on the basis of animal and epidemiological studies. The authors recently reported updated associations between lung cancer and beryllium exposure in a large, pooled occupational cohort. The authors conducted the present study to evaluate the shape of exposure-response associations between different exposure metrics and lung cancer in this cohort, considering potential confounders (race, plant, professional and short-term work status, and exposure to other lung carcinogens). METHODS: The authors conducted Cox proportional hazards regression analyses of lung cancer risk with cumulative, mean and maximum 'daily weighted average' (DWA) exposure among 5436 workers, using age-based risk sets. Different exposure-response curves were fitted to the exposure metrics, including categorical, power, restricted cubic spline and piecewise log-linear fits. RESULTS: The authors found significant positive associations between lung cancer and mean (p<0.0001) and maximum (p<0.0001) exposure, adjusting for age, birth cohort and plant, and for cumulative (p=0.0017) beryllium exposure, adjusting for these factors plus short-term work status and exposure to asbestos. The best-fitting models were generally categorical or piecewise log-linear, with the steepest increase in lung cancer risk between 0 and 10 mu g/m3 for both mean and maximum DWA exposure and between 0 and 200 mu g/m3-days for cumulative DWA exposure. The estimated mean DWA beryllium exposure associated with 10-3 excess lifetime risk based on the piecewise log-linear model is 0.033 mu g/m3. CONCLUSION: This study provides evidence that lung cancer risk is elevated at levels near the current US Occupational Safety and Health Administration beryllium exposure limit of 2.0 mu g/m3 DWA for workers. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary K AU - Deddens, James A AU - Couch, James R AU - Petersen, Martin R AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 354 EP - 360 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Asbestos KW - Age KW - Dose-response effects KW - Beryllium KW - Occupational safety KW - Carcinogens KW - Cancer KW - Occupational exposure KW - Lung cancer KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904469626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Risk+of+lung+cancer+associated+with+quantitative+beryllium+exposure+metrics+within+an+occupational+cohort&rft.au=Schubauer-Berigan%2C+Mary+K%3BDeddens%2C+James+A%3BCouch%2C+James+R%3BPetersen%2C+Martin+R&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2011-01-01&rft.volume=68&rft.issue=5&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Asbestos; Dose-response effects; Occupational safety; Beryllium; Carcinogens; Occupational exposure; Cancer; Lung cancer ER - TY - JOUR T1 - Role of a child death review team in a small rural county in California AN - 904469316; 14300084 AB - Humboldt County is one of California's most rural counties. Located in far Northern California, it is 6-7 h by car from the nearest major urban areas of San Francisco and Sacramento. In landmass it is one of the largest of the California counties, about the size of Rhode Island. In 1991, the Humboldt County Public Health Branch began a Fetal Infant Mortality Review programme. Because of the county's small size, the Fetal Infant Mortality Review process was combined with the review of child deaths through age 17. Responding to a high proportion of cases of child deaths due to unintentional injury, the team developed a workgroup to explore injury prevention strategies. Funding was identified to hire a coordinator who formed a Childhood Injury Prevention Program and developed a strategic plan. The plan prioritised both motor vehicle/traffic safety related injuries and general childhood injury. Funding was obtained for child passenger safety and youth safe driving programmes. The Childhood Injury Prevention Program also collaboratively addressed other injury prevention areas, including water safety. As a small, rural county in California, committed safety advocates from multiple agencies were able to utilise the child death review process to guide injury prevention efforts. Case reviews provided the motivation and quantitative and qualitative data to design programmes and implement interventions that addressed specific unintentional injuries causing child deaths and injuries in Humboldt County. JF - Injury Prevention AU - Keleher, Nancy AU - Arledge, Dawn N AD - Humboldt County Department of Health and Human Services, Public Health Branch, Eureka, California, USA Y1 - 2011 PY - 2011 DA - 2011 SP - i19 EP - i22 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 17 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - infant mortality KW - USA, California, Sacramento KW - Children KW - Public health KW - safety engineering KW - USA, California, Humboldt Cty. KW - Reviews KW - prevention KW - USA, California, San Francisco KW - Rural areas KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904469316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Role+of+a+child+death+review+team+in+a+small+rural+county+in+California&rft.au=Keleher%2C+Nancy%3BArledge%2C+Dawn+N&rft.aulast=Keleher&rft.aufirst=Nancy&rft.date=2011-01-01&rft.volume=17&rft.issue=&rft.spage=i19&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; safety engineering; infant mortality; Injuries; Reviews; prevention; Children; Public health; Rural areas; USA, California, Sacramento; USA, California, Humboldt Cty.; USA, California, San Francisco ER - TY - JOUR T1 - Green Tea Extract-Induced Lethal Toxicity in Fasted but Not in Nonfasted Dogs AN - 904468744; 14388353 AB - Recent chronic toxicity studies performed on green tea extracts in fasted dogs have revealed some unique dose-limiting lethal liver, gastrointestinal, and renal toxicities. Key findings included necrosis of hepatic cells, gastrointestinal epithelia and renal tubules, atrophy of reproductive organs, atrophy and necrosis of hematopoietic tissues, and associated hematological changes. The polyphenol cachetins (a mixture of primarily epigallocatechin gallate [ greater than or equal to 55%]; plus up to 10% each of epigallocatechin, epicatechin, and epigallocatechin gallate) appeared to be the causative agents for the observed toxicities because they are the active ingredients of green tea extract studied. Conduct of the study in nonfasted dogs under the same testing conditions and dose levels showed unremarkable results. Assuming both studies were valid, at the identified no observed adverse effect levels (NOAEL) of each study, systemic exposures (based on area under the curve [AUC]) were actually lower in fasted than nonfasted dogs, suggesting that fasting may have rendered the target organ systems potentially more vulnerable to the effects of green tea extract. The toxicity mechanisms that produced lethality are not known, but the results are scientifically intriguing. Because tea drinking has become more popular in the United States and abroad, the mode of action and site of action of green tea extract-induced lethal toxicities during fasting and the role of other phytochemical components of Folia Camellia sinensis (including nonpolyphenol fractions, which are often consumed when whole-leaf products are presented) warrant further investigation. JF - International Journal of Toxicology AU - Wu, Kuei-Meng AU - Yao, Jiaqin AU - Boring, Daniel AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration (CDER FDA), Silver Spring, MD, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 19 EP - 20 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 30 IS - 1 SN - 1091-5818, 1091-5818 KW - Toxicology Abstracts KW - Drinking KW - Polyphenols KW - green tea KW - Fasting KW - Toxicity KW - epigallocatechin gallate KW - Necrosis KW - Lethality KW - renal tubules KW - Chronic toxicity KW - Camellia sinensis KW - Liver KW - Kidney KW - Hemopoiesis KW - Atrophy KW - Reproductive organs KW - epicatechin KW - Side effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Toxicology&rft.atitle=Green+Tea+Extract-Induced+Lethal+Toxicity+in+Fasted+but+Not+in+Nonfasted+Dogs&rft.au=Wu%2C+Kuei-Meng%3BYao%2C+Jiaqin%3BBoring%2C+Daniel&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2011-01-01&rft.volume=30&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Toxicology&rft.issn=10915818&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Drinking; Polyphenols; green tea; Toxicity; Fasting; epigallocatechin gallate; Necrosis; Lethality; renal tubules; Chronic toxicity; Kidney; Liver; Hemopoiesis; Atrophy; Reproductive organs; epicatechin; Side effects; Camellia sinensis ER - TY - JOUR T1 - Evaluation of the COSHH Essentials Model with a Mixture of Organic Chemicals at a Medium-Sized Paint Producer AN - 904468594; 14219597 AB - The Control of Substances Hazardous to Health (COSHH) Essentials model was evaluated using full-shift exposure measurements of five chemical components in a mixture [acetone, ethylbenzene, methyl ethyl ketone, toluene, and xylenes] at a medium-sized plant producing paint materials. Two tasks, batch-making and bucket-washing, were examined. Varying levels of control were already established in both tasks and the average exposures of individual chemicals were considerably lower than the regulatory and advisory 8-h standards. The average exposure fractions using the additive mixture formula were also less than unity (batch-making: 0.25, bucket-washing: 0.56) indicating the mixture of chemicals did not exceed the combined occupational exposure limit (OEL). The paper version of the COSHH Essentials model was used to calculate a predicted exposure range (PER) for each chemical according to different levels of control. The estimated PERs of the tested chemicals for both tasks did not show consistent agreement with exposure measurements when the comparison was made for each control method and this is believed to be because of the considerably different volatilities of the chemicals. Given the combination of health hazard and exposure potential components, the COSHH Essentials model recommended a control approach 'special advice' for both tasks, based on the potential reproductive hazard ascribed to toluene. This would not have been the same conclusion if some other chemical had been substituted (for example styrene, which has the same threshold limit value as toluene). Nevertheless, it was special advice, which had led to the combination of hygienic procedures in place at this plant. The probability of the combined exposure fractions exceeding unity was 0.0002 for the batch-making task indicating that the employees performing this task were most likely well protected below the OELs. Although the employees involved in the bucket-washing task had greater potential to exceed the threshold limit value of the mixture (P > 1 = 0.2375), the expected personal exposure after adjusting for the assigned protection factor for the respirators in use would be considerably lower (P > 1 = 0.0161). Thus, our findings suggested that the COSHH essentials model worked reasonably well for the volatile organic chemicals at the plant. However, it was difficult to override the reproductive hazard even though it was meant to be possible in principle. Further, it became apparent that an input of existing controls, which is not possible in the web-based model, may have allowed the model be more widely applicable. The experience of using the web-based COSHH Essentials model generated some suggestions to provide a more user-friendly tool to the model users who do not have expertise in occupational hygiene. JF - Annals of Occupational Hygiene AU - Lee, Eun Gyung AU - Slaven, James AU - Bowen, Russell B AU - Harper, Martin AD - Exposure Assessment Branch, Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV 26505, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 16 EP - 29 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 55 IS - 1 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Chemical analysis KW - Chemicals KW - Occupational exposure KW - Occupational health KW - Paints KW - Threshold limits KW - Toluene KW - acetone KW - uncertainty UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Evaluation+of+the+COSHH+Essentials+Model+with+a+Mixture+of+Organic+Chemicals+at+a+Medium-Sized+Paint+Producer&rft.au=Lee%2C+Eun+Gyung%3BSlaven%2C+James%3BBowen%2C+Russell+B%3BHarper%2C+Martin&rft.aulast=Lee&rft.aufirst=Eun&rft.date=2011-01-01&rft.volume=55&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Chemicals; acetone; Toluene; Threshold limits; Chemical analysis; Occupational exposure; uncertainty; Occupational health; Paints ER - TY - JOUR T1 - Occupation and bladder cancer in a population-based case-control study in Northern New England AN - 904468333; 14516847 AB - OBJECTIVES: We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. METHODS: Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial carcinoma of the bladder in 2001-2004, and from 1402 population controls. Unconditional logistic regression was used to calculate ORs and 95% CIs, adjusted for demographic factors, smoking and employment in other high-risk occupations. RESULTS: Male precision metalworkers and metalworking/plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR 2.2, 95% CI 1.4 to 3.4, ptrend=0.0065; metalworking/plasticworking machine operators: OR 1.6, 95% CI 1.01 to 2.6, ptrend=0.047). Other occupations/industries for which risk increased significantly with duration of employment included: for men, textile machine operators, mechanics/repairers, automobile mechanics, plumbers, computer systems analysts, information clerks, and landscape industry workers; for women, service occupations, health services, cleaning and building services, management-related occupations, electronic components manufacturing and transportation equipment manufacturing. Men reporting use of metalworking fluids (MWF) had a significantly elevated bladder cancer risk (OR 1.7, 95% CI 1.1 to 2.5). CONCLUSIONS: Our findings support the hypothesis that some component(s) of MWF may be carcinogenic to the bladder. Our results also corroborate many other previously reported associations between bladder cancer risk and various occupations. More detailed analyses using information from the study's job-specific questionnaires may help to identify MWF components that may be carcinogenic, and other bladder carcinogens associated with a variety of occupations. JF - Occupational and Environmental Medicine AU - Colt, Joanne S AU - Karagas, Margaret R AU - Schwenn, Molly AU - Baris, Dalsu AU - Johnson, Alison AU - Stewart, Patricia AU - Verrill, Castine AU - Moore, Lee E AU - Lubin, Jay AU - Ward, Mary H AU - Samanic, Claudine AU - Rothman, Nathaniel AU - Cantor, Kenneth P AU - Beane Freeman, Laura E AU - Schned, Alan AU - Cherala, Sai AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 239 EP - 249 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 68 IS - 4 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts KW - demography KW - Historical account KW - employment KW - Landscape KW - Carcinogens KW - urinary bladder KW - Transportation KW - USA, New England KW - Carcinogenicity KW - USA, Maine KW - USA, New Hampshire KW - USA, Vermont KW - population control KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupation+and+bladder+cancer+in+a+population-based+case-control+study+in+Northern+New+England&rft.au=Colt%2C+Joanne+S%3BKaragas%2C+Margaret+R%3BSchwenn%2C+Molly%3BBaris%2C+Dalsu%3BJohnson%2C+Alison%3BStewart%2C+Patricia%3BVerrill%2C+Castine%3BMoore%2C+Lee+E%3BLubin%2C+Jay%3BWard%2C+Mary+H%3BSamanic%2C+Claudine%3BRothman%2C+Nathaniel%3BCantor%2C+Kenneth+P%3BBeane+Freeman%2C+Laura+E%3BSchned%2C+Alan%3BCherala%2C+Sai%3BSilverman%2C+Debra+T&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2011-01-01&rft.volume=68&rft.issue=4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - demography; Historical account; urinary bladder; Transportation; employment; Carcinogenicity; Landscape; Carcinogens; population control; USA, New England; USA, Maine; USA, New Hampshire; USA, Vermont ER - TY - JOUR T1 - Serum C-Reactive Protein and Risk of Pancreatic Cancer in Two Nested, Case-Control Studies AN - 904467482; 14340340 AB - BACKGROUND: Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results. METHODS: We conducted two nested, case-control studies in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to test whether prediagnostic circulating CRP concentrations were associated with pancreatic adenocarcinoma. Between 1985 and 2004, 311 cases occurred in ATBC and between 1994 and 2006, 182 cases occurred in PLCO. Controls (n = 510 in ATBC, n = 374 in PLCO) were alive at the time the case was diagnosed and were matched by age, date of blood draw, sex, and race. We used conditional logistic regression adjusted for smoking to calculate OR and 95% CI for pancreatic cancer. RESULTS: CRP concentrations (ng/mL) tended to be inversely or not associated with pancreatic cancer risk in ATBC, PLCO, and combined analyses [per standardized quintile increase in CRP, continuous OR = 0.94 (95% CI, 0.89-0.99), OR = 0.99 (95% CI, 0.95-1.04), OR = 0.98 (95% CI, 0.95-1.01), respectively]. In combined analyses, we observed a significant interaction (Pinteraction = 0.02) such that inverse associations were suggestive in younger (OR = 0.95; 95% CI, 0.90-1.01), but not older, participants. CONCLUSION: Our results do not support the hypothesis that higher CRP concentrations are associated with incident pancreatic cancer. IMPACT: Our results highlight the importance of investigating more specific biomarkers for inflammation that may reflect the biological mechanisms underlying pancreatic cancer in prospective cohort studies. Cancer Epidemiol Biomarkers Prev; 20(2); 359-69. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Douglas, Jason B AU - Silverman, Debra T AU - Weinstein, Stephanie J AU - Graubard, Barry I AU - Pollak, Michael N AU - Tao, Yuzhen AU - Virtamo, Jarmo AU - Albanes, Demetrius AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Nutritional Epidemiology Branch, Occupational Epidemiology Branch, and Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland Y1 - 2011 PY - 2011 DA - 2011 SP - 359 EP - 369 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 20 IS - 2 SN - 1055-9965, 1055-9965 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Bioindicators KW - Cancer KW - Lung KW - Prevention KW - Proteins KW - Smoking KW - Standards KW - ovarian carcinoma KW - pancreatic cancer KW - prevention KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+C-Reactive+Protein+and+Risk+of+Pancreatic+Cancer+in+Two+Nested%2C+Case-Control+Studies&rft.au=Douglas%2C+Jason+B%3BSilverman%2C+Debra+T%3BWeinstein%2C+Stephanie+J%3BGraubard%2C+Barry+I%3BPollak%2C+Michael+N%3BTao%2C+Yuzhen%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Douglas&rft.aufirst=Jason&rft.date=2011-01-01&rft.volume=20&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Bioindicators; Smoking; Age; Prevention; pancreatic cancer; Lung; ovarian carcinoma; prevention; Proteins; Standards; Cancer ER - TY - JOUR T1 - Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells AN - 904463923; 14221235 AB - Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer. JF - Toxicology and Industrial Health AU - Lyn-Cook, Lascelles E AU - Tareke, Eden AU - Word, Beverly AU - Starlard-Davenport, Athena AU - Lyn-Cook, Beverly D AU - Hammons, George J AD - University of Arkansas at Little Rock, Little Rock, AR, USA. National Center for Toxicological Research, Jefferson, AR, USA. National Center for Toxicological Research, Jefferson, AR, USA. National Center for Toxicological Research, Jefferson, AR, USA. National Center for Toxicological Research, Jefferson, AR, USA. National Center for Toxicological Research, Jefferson, AR, USA., ghammons@nctr.fda.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 11 EP - 18 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 27 IS - 1 SN - 0748-2337, 0748-2337 KW - Pollution Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Diets KW - Cyclooxygenase-2 KW - Temperature effects KW - Epithelial cells KW - Data processing KW - Food KW - Metabolites KW - Carcinogens KW - Food contamination KW - Cancer KW - Nitric-oxide synthase KW - Acrylamide KW - Cooking KW - Breast cancer KW - Nitric oxide KW - cooking KW - Contaminants KW - high temperature KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Food+contaminant+acrylamide+increases+expression+of+Cox-2+and+nitric+oxide+synthase+in+breast+epithelial+cells&rft.au=Lyn-Cook%2C+Lascelles+E%3BTareke%2C+Eden%3BWord%2C+Beverly%3BStarlard-Davenport%2C+Athena%3BLyn-Cook%2C+Beverly+D%3BHammons%2C+George+J&rft.aulast=Lyn-Cook&rft.aufirst=Lascelles&rft.date=2011-01-01&rft.volume=27&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cyclooxygenase-2; Nitric-oxide synthase; Epithelial cells; Data processing; Acrylamide; Food; Cooking; Breast cancer; Metabolites; Carcinogens; Food contamination; Diets; cooking; Nitric oxide; Contaminants; high temperature; Cancer ER - TY - JOUR T1 - Analysis of Lognormally Distributed Exposure Data with Repeated Measures and Values below the Limit of Detection Using SAS AN - 904463898; 14219590 AB - Studies of determinants of occupational exposure frequently involve left-censored lognormally distributed data, often with repeated measures. Left censoring occurs when observations are below the analytical limit of detection (LOD); repeated measures data results from taking multiple measurements on the same worker. A common method of dealing with this type of data has been to substitute a value (such as LOD/2) for the censored data followed by statistical analysis using the 'usual' methods. Recently, maximum likelihood estimation (MLE) methods have been employed to reduce bias associated with the substitution method. We compared substitution and MLE methods using simulated lognormally distributed exposure data subjected to varying amounts of censoring using two procedures available in SAS: LIFEREG and NLMIXED. In these simulations, the MLE method resulted in less bias and performed well even for censoring up to 80%, whereas the substitution method resulted in considerable bias. We illustrate the NLMIXED procedure using a dataset of chlorpyrifos air measurements collected from termiticide applicators on consecutive days over a 5-day workweek. We provide sample SAS code for several situations including one and two groups, with and without repeated measures, random slopes, and nested random effects. JF - Annals of Occupational Hygiene AU - Jin, Yan AU - Hein, Misty J AU - Deddens, James A AU - Hines, Cynthia J AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 97 EP - 112 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 55 IS - 1 SN - 0003-4878, 0003-4878 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chlorpyrifos KW - Data processing KW - Occupational exposure KW - Occupational health KW - Pesticides KW - Simulation KW - Statistical analysis KW - Workers KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Analysis+of+Lognormally+Distributed+Exposure+Data+with+Repeated+Measures+and+Values+below+the+Limit+of+Detection+Using+SAS&rft.au=Jin%2C+Yan%3BHein%2C+Misty+J%3BDeddens%2C+James+A%3BHines%2C+Cynthia+J&rft.aulast=Jin&rft.aufirst=Yan&rft.date=2011-01-01&rft.volume=55&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Workers; Data processing; Statistical analysis; Occupational exposure; Pesticides; Simulation; Occupational health ER - TY - JOUR T1 - Release of Beryllium from Beryllium-Containing Materials in Artificial Skin Surface Film Liquids AN - 904463412; 14219594 AB - Purpose: Skin exposure to soluble beryllium compounds causes systemic sensitization in humans. Penetration of poorly soluble particles through intact skin has been proposed as a mechanism for beryllium sensitization; however, this mechanism is controversial. The purpose of this study was to investigate the hypothesis that particulate beryllium compounds in contact with skin surface release ions via dissolution in sweat. Methods: Dissolution of 11 particulate beryllium materials (hydroxide, metal, oxides and copper-beryllium fume), 3 copper-beryllium alloy reference materials (chips and solid block), and 4 copper-beryllium alloy tools was measured over 7 days in artificial sweat buffered to pH 5.3 and pH 6.5. Results: All test materials released beryllium ions in artificial sweat. Particulate from a reduction furnace that contained both crystalline and amorphous beryllium was the most soluble compound-40% dissolved in 8 h. Rates of beryllium release from all other particulate and reference materials were faster at pH 5.3 than at pH 6.5 (P < 0.05). At pH 5.3, values of the chemical dissolution rate constant, k [g (cm2 day)-1] differed significantly for hydroxide, metal, and oxide -1.7 plus or minus 0.0 x 10-7, 1.7 plus or minus 0.6 x 10-8, and 1.0 plus or minus 0.5 x 10-9, respectively (P < 0.05). Up to 30 mu g of beryllium was released from the alloy tools within 1 h. Dissolution rates in artificial sweat were equal to or faster than values previously determined for these materials in lung models. Conclusions: Poorly soluble beryllium materials undergo dissolution in artificial sweat, suggesting that skin exposure is a biologically plausible pathway for development of sensitization. Skin surface acidity, which is regulated by sweat chemistry and bacterial hydrolysis of sebum lipids varies by anatomical region and may be an exposure-modifying factor for beryllium particle dissolution. JF - Annals of Occupational Hygiene AU - Stefaniak, Aleksandr B AU - Virji, MAbbas AU - Day, Gregory A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 57 EP - 69 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 55 IS - 1 SN - 0003-4878, 0003-4878 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Lipids KW - Sweat KW - Particulates KW - Models KW - Alloys KW - oxides KW - alloys KW - Beryllium compounds KW - Acidity KW - pH effects KW - pH KW - Ions KW - Metals KW - Skin KW - Fumes KW - Hydrolysis KW - hydroxides KW - Lung KW - Beryllium KW - Dissolution KW - J 02400:Human Diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Release+of+Beryllium+from+Beryllium-Containing+Materials+in+Artificial+Skin+Surface+Film+Liquids&rft.au=Stefaniak%2C+Aleksandr+B%3BVirji%2C+MAbbas%3BDay%2C+Gregory+A&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2011-01-01&rft.volume=55&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Metals; Ions; Fumes; Skin; Sweat; Lipids; Hydrolysis; Models; Lung; Beryllium; Dissolution; oxides; alloys; Acidity; pH effects; hydroxides; Alloys; Particulates; Beryllium compounds; pH ER - TY - JOUR T1 - Characteristics of Beryllium Exposure to Small Particles at a Beryllium Production Facility AN - 904463409; 14219592 AB - Epidemiological studies have reported process-specific elevated prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) among workers. However, exposure-response relationships have been inconsistent, possibly due to incomplete characterization of many biologically relevant aspects of exposure, including particle size. In 1999, two surveys were conducted 3-5 months apart at a beryllium metal, oxide, and alloy production facility during which personal impactor samples (n = 198) and personal 37-mm closed-face cassette (CFC) 'total' samples (n = 4026) were collected. Among process areas, median particle mass median aerodynamic diameter ranged from 5 to 14 mu m. A large fraction of the beryllium aerosol was in the nonrespirable size range. Respirable beryllium concentrations were among the highest for oxide production [geometric mean (GM) = 2.02 mu g m-3, geometric standard deviation (GSD) = 1.3] and pebbles plant (GM = 1.05 mu g m-3, GSD = 2.9), areas historically associated with high risk of BeS and CBD. The relationship between GM 'CFC total' and GM respirable beryllium for jobs varied by process areas; the rank order of the jobs showed high overall consistency (Spearman r = 0.84), but the overall correlation was moderate (Pearson r = 0.43). Total beryllium concentrations varied greatly within and between workers among process areas; within-worker variance was larger than between-worker variance for most processes. A review of exposure characteristics among process areas revealed variation in chemical forms and solubility. Process areas with high risk of BeS and CBD had exposure to both soluble and insoluble forms of beryllium. Consideration of biologically relevant aspects of exposure such as beryllium particle size distribution, chemical form, and solubility will likely improve exposure assessment. JF - Annals of Occupational Hygiene AU - Virji, MAbbas AU - Stefaniak, Aleksandr B AU - Day, Gregory A AU - Stanton, Marcia L AU - Kent, MIchael S AU - Kreiss, Kathleen AU - Schuler, Christine R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 70 EP - 85 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 55 IS - 1 SN - 0003-4878, 0003-4878 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Aerosols KW - Alloys KW - Berylliosis KW - Beryllium KW - Dose-response effects KW - Metals KW - Occupational exposure KW - Particle size KW - Particulates KW - Reviews KW - Risk factors KW - Size distribution KW - Solubility KW - Standard deviation KW - Workers KW - alloys KW - oxides KW - X 24360:Metals KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Characteristics+of+Beryllium+Exposure+to+Small+Particles+at+a+Beryllium+Production+Facility&rft.au=Virji%2C+MAbbas%3BStefaniak%2C+Aleksandr+B%3BDay%2C+Gregory+A%3BStanton%2C+Marcia+L%3BKent%2C+MIchael+S%3BKreiss%2C+Kathleen%3BSchuler%2C+Christine+R&rft.aulast=Virji&rft.aufirst=MAbbas&rft.date=2011-01-01&rft.volume=55&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Berylliosis; Metals; Aerosols; Solubility; Workers; Standard deviation; Risk factors; Reviews; Dose-response effects; Beryllium; oxides; alloys; Size distribution; Particle size; Alloys; Particulates; Occupational exposure ER - TY - JOUR T1 - Neurotoxicity Following Acute Inhalation Exposure to the Oil Dispersant COREXIT EC9500A AN - 902372673; 15876011 AB - Consequent to the 2010 Deepwater Horizon oil spill in the Gulf of Mexico, there is an emergent concern about the short- and long-term adverse health effects of exposure to crude oil, weathered-oil products, and oil dispersants among the workforce employed to contain and clean up the spill. Oil dispersants typically comprise of a mixture of solvents and surfactants that break down floating oil to micrometer-sized droplets within the water column, thus preventing it from reaching the shorelines. As dispersants are generally sprayed from the air, workers are at risk for exposure primarily via inhalation. Such inhaled fractions might potentially permeate or translocate to the brain via olfactory or systemic circulation, producing central nervous system (CNS) abnormalities. To determine whether oil dispersants pose a neurological risk, male Sprague-Dawley rats were exposed by whole-body inhalation exposure to a model oil dispersant, COREXIT EC9500A (CE; approximately 27 mg/m3X5 h/dX1 d), and various molecular indices of neural dysfunction were evaluated in discrete brain areas, at 1 or 7 d postexposure. Exposure to CE produced partial loss of olfactory marker protein in the olfactory bulb. CE also reduced tyrosine hydroxylase protein content in the striatum. Further, CE altered the levels of various synaptic and neuronal intermediate filament proteins in specific brain areas. Reactive astrogliosis, as evidenced by increased expression of glial fibrillary acidic protein, was observed in the hippocampus and frontal cortex following exposure to CE. Collectively, these findings are suggestive of disruptions in olfactory signal transduction, axonal function, and synaptic vesicle fusion, events that potentially result in an imbalance in neurotransmitter signaling. Whether such acute molecular aberrations might persist and produce chronic neurological deficits remains to be ascertained. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Goldsmith, William T AU - Jackson, Mark AU - McKinney, Walter AU - Frazer, David G AU - Robinson, Victor A AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 1405 EP - 1418 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 21 SN - 1528-7394, 1528-7394 KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Inhalation KW - Central nervous system KW - Neurological diseases KW - Glial fibrillary acidic protein KW - Water column KW - Oil KW - Rats KW - Neostriatum KW - Neurotransmitters KW - Occupational exposure KW - Motor task performance KW - Solvents KW - Brain KW - Dispersants KW - olfactory marker protein KW - ASW, Mexico Gulf KW - Neurotoxicity KW - Proteins KW - Gliosis KW - Intermediate filaments KW - Tyrosine 3-monooxygenase KW - Surfactants KW - Signal transduction KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902372673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Neurotoxicity+Following+Acute+Inhalation+Exposure+to+the+Oil+Dispersant+COREXIT+EC9500A&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BGoldsmith%2C+William+T%3BJackson%2C+Mark%3BMcKinney%2C+Walter%3BFrazer%2C+David+G%3BRobinson%2C+Victor+A%3BCastranova%2C+Vincent&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2011-01-01&rft.volume=74&rft.issue=21&rft.spage=1405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.606796 L2 - http://www.tandfonline.com/doi/abs/10.1080/15287394.2011.606796 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inhalation; Central nervous system; Neurological diseases; Motor task performance; Brain; Glial fibrillary acidic protein; Solvents; Dispersants; olfactory marker protein; Water column; Neostriatum; Neurotoxicity; Gliosis; Neurotransmitters; Intermediate filaments; Tyrosine 3-monooxygenase; Surfactants; Occupational exposure; Signal transduction; Rats; Oil; Proteins; ASW, Mexico Gulf DO - http://dx.doi.org/10.1080/15287394.2011.606796 ER - TY - JOUR T1 - Pulmonary Effects after Acute Inhalation of Oil Dispersant (COREXIT EC9500A) in Rats AN - 902372657; 15876009 AB - COREXIT EC9500A (COREXIT) was used to disperse crude oil during the 2010 Deepwater Horizon oil spill. While the environmental impact of COREXIT has been examined, the pulmonary effects are unknown. Investigations were undertaken to determine whether inhaled COREXIT elicits airway inflammation, alters pulmonary function or airway reactivity, or exerts pharmacological effects. Male rats were exposed to COREXIT (mean 27 mg/m3, 5 h). Bronchoalveolar lavage was performed on d 1 and 7 postexposure. Lactate dehydrogenase (LDH) and albumin were measured as indices of lung injury; macrophages, neutrophils, lymphocytes, and eosinophils were quantified to evaluate inflammation; and oxidant production by macrophages and neutrophils was measured. There were no significant effects of COREXIT on LDH, albumin, inflammatory cell levels or oxidant production at either time point. In conscious animals, neither breathing frequency nor specific airway resistance were altered at 1 hr, 1 d and 7 d postexposure. Airway resistance responses to methacholine (MCh) aerosol in anesthetized animals were unaffected at 1 and 7 d postexposure, while dynamic compliance responses were decreased after 1 d but not 7 d. In tracheal strips, in the presence or absence of MCh, low concentrations of COREXIT (0.001% v/v) elicited relaxation; contraction occurred at 0.003--0.1% v/v. In isolated, perfused trachea, intraluminally applied COREXIT produced similar effects but at higher concentrations. COREXIT inhibited neurogenic contractile responses of strips to electrical field stimulation. Our findings suggest that COREXIT inhalation did not initiate lung inflammation, but may transiently increase the difficulty of breathing. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Roberts, Jenny R AU - Reynolds, Jeffrey S AU - Thompson, Janet A AU - Zaccone, Eric J AU - Shimko, Michael J AU - Goldsmith, William T AU - Jackson, Mark AU - McKinney, Walter AU - Frazer, David G AU - Kenyon, Allison AU - Kashon, Michael L AU - Piedimonte, Giovanni AU - Castranova, Vincent AU - Fedan, Jeffrey S AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2011 PY - 2011 DA - 2011 SP - 1381 EP - 1396 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 21 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Inhalation KW - Macrophages KW - Injuries KW - Respiration KW - Compliance KW - Lymphocytes KW - Leukocytes (eosinophilic) KW - Rats KW - Crude oil KW - Bronchus KW - methacholine KW - Trachea KW - Respiratory tract KW - Aerosols KW - Environmental impact KW - Leukocytes (neutrophilic) KW - Dispersants KW - Alveoli KW - L-Lactate dehydrogenase KW - Inflammation KW - Respiratory tract diseases KW - Lung KW - Albumin KW - Oxidants KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902372657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Pulmonary+Effects+after+Acute+Inhalation+of+Oil+Dispersant+%28COREXIT+EC9500A%29+in+Rats&rft.au=Roberts%2C+Jenny+R%3BReynolds%2C+Jeffrey+S%3BThompson%2C+Janet+A%3BZaccone%2C+Eric+J%3BShimko%2C+Michael+J%3BGoldsmith%2C+William+T%3BJackson%2C+Mark%3BMcKinney%2C+Walter%3BFrazer%2C+David+G%3BKenyon%2C+Allison%3BKashon%2C+Michael+L%3BPiedimonte%2C+Giovanni%3BCastranova%2C+Vincent%3BFedan%2C+Jeffrey+S&rft.aulast=Roberts&rft.aufirst=Jenny&rft.date=2011-01-01&rft.volume=74&rft.issue=21&rft.spage=1381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.606794 L2 - http://www.tandfonline.com/doi/abs/10.1080/15287394.2011.606794 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Inhalation; Aerosols; Injuries; Respiration; Leukocytes (neutrophilic); Leukocytes (eosinophilic); Dispersants; Alveoli; Inflammation; L-Lactate dehydrogenase; Respiratory tract diseases; Bronchus; methacholine; Lung; Albumin; Trachea; Oxidants; Respiratory tract; Rats; Crude oil; Compliance; Environmental impact; Lymphocytes DO - http://dx.doi.org/10.1080/15287394.2011.606794 ER - TY - JOUR T1 - Performance Evaluation of 26 Combinations of Chemical Protective Clothing Materials and Chemicals After Repeated Exposures and Decontaminations AN - 902366339; 15875952 AB - Effective decontamination of chemical protective clothing (CPC) is essential for reducing occupational skin diseases and disorders during a reuse scenario. To protect the workforce, the efficacy of decontamination methods and the reusability of CPC need to be evaluated. In this study, performance of 14 CPC materials against 12 liquid chemicals was evaluated based on standardized breakthrough time (BT) and steady-state permeation rate (SSPR). Thermal and water-detergent decontamination methods were used. Exposure/decon- tamination was repeated up to 11 cycles, or until the material failed, so that further testing became impossible. Changes in BT and SSPRs were determined for each material and chemical combination. There were 20 and 13 combinations that were able to complete 11 cycles with thermal and detergent methods, respectively. By comparing the beginning and ending cycles, mean BT increased 9% with the thermal method but slightly decreased (3.3%) with the detergent method, while mean SSPR decreased 2% with the thermal method, but slightly increased (1.4%) with the detergent method. Less than half of the changes were found statistically different (p < 0.05). Generally, the thermal method had higher decontamination efficacy than the detergent method. JF - Journal of Occupational and Environmental Hygiene AU - Gao, Pengfei AU - Tomasovic, Beth AU - Stein, Lauren AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania Y1 - 2011 PY - 2011 DA - 2011 SP - 625 EP - 635 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 8 IS - 11 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Protective clothing KW - occupational diseases KW - Detergents KW - Decontamination KW - Standards KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902366339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Performance+Evaluation+of+26+Combinations+of+Chemical+Protective+Clothing+Materials+and+Chemicals+After+Repeated+Exposures+and+Decontaminations&rft.au=Gao%2C+Pengfei%3BTomasovic%2C+Beth%3BStein%2C+Lauren&rft.aulast=Gao&rft.aufirst=Pengfei&rft.date=2011-01-01&rft.volume=8&rft.issue=11&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.616161 L2 - http://www.tandfonline.com/doi/abs/10.1080/15459624.2011.616161 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Protective clothing; occupational diseases; Detergents; Decontamination; Standards DO - http://dx.doi.org/10.1080/15459624.2011.616161 ER - TY - JOUR T1 - Exposure Characterization of Metal Oxide Nanoparticles in the Workplace AN - 902366228; 15875944 AB - This study presents exposure data for various metal oxides in facilities that produce or use nanoscale metal oxides. Exposure assessment surveys were conducted at seven facilities encompassing small, medium, and large manufacturers and end users of nanoscale (particles <0.1 Delta *mm diameter) metal oxides, including the oxides of titanium, magnesium, yttrium, aluminum, calcium, and iron. Half- and full-shift sampling consisting of various direct-reading and mass-based area and personal aerosol sampling was employed to measure exposure for various tasks. Workers in large facilities performing handling tasks had the highest mass concentrations for all analytes. However, higher mass concentrations occurred in medium facilities and during production for all analytes in area samples. Medium-sized facilities had higher particle number concentrations in the air, followed by small facilities for all particle sizes measured. Production processes generally had the highest particle number concentrations, particularly for the smaller particles. Similar to particle number, the medium-sized facilities and production process had the highest particle surface area concentration. TEM analysis confirmed the presence of the specific metal oxides particles of interest, and the majority of the particles were agglomerated, with the predominant particle size being between 0.1 and 1 Delta *mm. The greatest potential for exposure to workers occurred during the handling process. However, the exposure is occurring at levels that are well below established and proposed limits. JF - Journal of Occupational and Environmental Hygiene AU - Curwin, Brian AU - Bertke, Steve AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio Y1 - 2011 PY - 2011 DA - 2011 SP - 580 EP - 587 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 8 IS - 10 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Particle size KW - Metals KW - Calcium KW - Aluminum KW - Air sampling KW - Yttrium KW - Particulates KW - Iron KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902366228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Exposure+Characterization+of+Metal+Oxide+Nanoparticles+in+the+Workplace&rft.au=Curwin%2C+Brian%3BBertke%2C+Steve&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2011-01-01&rft.volume=8&rft.issue=10&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2011.613348 L2 - http://www.tandfonline.com/doi/abs/10.1080/15459624.2011.613348 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Particle size; Metals; Calcium; Aluminum; Yttrium; Air sampling; Particulates; Iron; Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2011.613348 ER - TY - JOUR T1 - Addiction Research Centres and the Nurturing of Creativity AN - 902085351; 201123856 AB - The aim of this paper is to present a concise account of the history, mission, structure and some recent achievements of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). Created by the US Congress 40 years ago, the NIAAA has evolved from an entity charged mainly with building a national system of alcoholism treatment services to one with responsibility for developing, nurturing and supporting the biomedical and behavioral science foundation necessary to reduce the significant domestic and global public health impact of alcohol use disorders. The NIAAA is unique in that it functions both as a funding agency, supporting research at universities and other external, or 'extramural' research institutions, and is also a research institution itself, where alcohol research is carried out in-house, or 'intramurally'. Of a $450.2 million 2009 Congressional Appropriation, approximately 90% was devoted toward the former and approximately 10% towards the latter objective. The current NIAAA Strategic Plan builds on a new organizing principle for long-range research planning, based on a life-span perspective that recognizes that human biology and behavior continue to change throughout life and changes occurring throughout the life-span affect individuals' drinking patterns as well as the decisions they may make to change their drinking habits or to seek help for alcohol use problems. Within this framework, major efforts are currently being devoted to educating practitioners on clinically useful, science-based assessment and treatment methods that exist today, and development of personalized new treatments for tomorrow. Adapted from the source document. JF - Addiction AU - Heilig, Markus AU - Warren, Kenneth R AU - Kunos, George AU - Silverman, Peter B AU - Hewitt, Brenda G AD - The National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1052 EP - 1060 PB - Blackwell Publishing, Oxford UK VL - 106 IS - 6 SN - 0965-2140, 0965-2140 KW - Alcohol Abuse KW - Public Health KW - Behavior Modification KW - Biomedicine KW - Alcoholism KW - United States of America KW - Addiction KW - Creativity KW - Biology KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902085351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addiction+Research+Centres+and+the+Nurturing+of+Creativity&rft.au=Heilig%2C+Markus%3BWarren%2C+Kenneth+R%3BKunos%2C+George%3BSilverman%2C+Peter+B%3BHewitt%2C+Brenda+G&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2011-01-01&rft.volume=106&rft.issue=6&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2010.02995.x LA - English DB - Sociological Abstracts N1 - Date revised - 2011-11-02 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Alcohol Abuse; United States of America; Alcoholism; Biomedicine; Biology; Creativity; Addiction; Behavior Modification; Public Health DO - http://dx.doi.org/10.1111/j.1360-0443.2010.02995.x ER - TY - JOUR T1 - Probabilistic risk assessment of dietary cadmium in the South Korean population AN - 899162370; 15715349 AB - Global interest in the adverse health effects of cadmium (Cd) has focused on dietary exposure as the principal source of Cd exposure to the general population. Common assumptions used in deterministic Cd assessment in global or regional diets have limitations when applied to specific national cases where local variation in food composition and consumption patterns are different than for global or regional norms. Stochastic dietary Cd exposure assessment was conducted for the general South Korean population to understand better Cd dietary intake. Because rice (Oryza sativa) is commonly and highly consumed by Koreans, it was the dominant contributor to Cd in the diet, representing on average 25% of the total dietary exposure for the general population. Hazard index (HI) values were below the level of concern for the 95th percentile of the general population. Sensitivity analyses demonstrated that variation in rice intake and Cd concentration had the greatest influence on the Cd risk estimate for the general population. Changes in food sources, such as the use of imported rice with higher Cd levels, would lead to increased Cd exposure in the diet, thus necessitating continued vigilance as to the status of Cd within the food supply. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Kim, M AU - Wolt, J D AD - Food Contaminants Division, Korea Food and Drug Administration, Seoul, South Korea Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 62 EP - 70 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 28 IS - 1 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Risk Abstracts KW - Diets KW - Risk assessment KW - Food supply KW - Oryza sativa KW - Ingestion KW - Food contamination KW - Dietary intake KW - Stochasticity KW - Food additives KW - sensitivity analysis KW - Food sources KW - Food composition KW - Vigilance KW - Cadmium KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899162370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Probabilistic+risk+assessment+of+dietary+cadmium+in+the+South+Korean+population&rft.au=Kim%2C+M%3BWolt%2C+J+D&rft.aulast=Kim&rft.aufirst=M&rft.date=2011-01-01&rft.volume=28&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2010.529620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Food sources; Food composition; Vigilance; Cadmium; Food contamination; Stochasticity; Dietary intake; Diets; Food supply; sensitivity analysis; Ingestion; Oryza sativa DO - http://dx.doi.org/10.1080/19440049.2010.529620 ER - TY - JOUR T1 - Locomotion in restricted space: Kinematic and electromyographic analysis of stoopwalking and crawling AN - 899133222; 14183872 AB - Stoopwalking and crawling are compulsory gait techniques in some occupational settings, as in low-seam coal mines (where vertical space may be less than 122 cm). Nine participants, six males and three females (mean = 35 years + 17 SD), participated in a study examining kinematic and electromyographic (EMG) responses to natural cadence stoopwalking, four-point crawling (all fours), and two-point crawling (knees only). EMG data were collected from knee extensors and flexors, and a motion analysis system was used to obtain kinematic data. The average gait velocity for stoopwalking was 1.01 (+/-0.32) m/s with an average cadence of 112.8 steps/min and stride length of 1.04 m. Four-point crawling velocity averaged 0.50 (+/-0.20) m/s, with average cadence of 86.3 steps/min and stride length of 0.69 m. Two-point crawling exhibited the slowest velocity (0.32 m/s) and shortest stride length (0.40 m); however, cadence was greater than four-point crawling (96.8 steps/min). EMG findings included prolonged contraction of both knee extensors and flexors (compared to normative data on normal walking), increased relative activity SD of the flexors (versus extensors) in two-point crawling, and decreased thigh muscle activity in four-point crawling. Interlimb coordination in four-point crawling trials indicated trot-like, no limb pairing, and near pace-like limb contact patterns. Presence or absence of kneepads had no impact on kinematic or EMG measures (p > 0.05); however, subjects complained of discomfort without kneepads (especially in two-point crawling). Results of this study have implications for work performed in underground coal mines, as well as emergency or evacuation considerations. JF - Gait & Posture AU - Gallagher, Sean AU - Pollard, Jonisha AU - Porter, William L AD - National Institute for Occupational Safety and Health, Office of Mine Safety and Health Research, PO Box 18070, Pittsburgh, PA 15236-0070, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 71 EP - 76 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 33 IS - 1 SN - 0966-6362, 0966-6362 KW - Physical Education Index KW - Kinematics KW - Pace KW - Analysis KW - Electromyography KW - Knees KW - Velocity KW - Work KW - Legs KW - Gait KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899133222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gait+%26+Posture&rft.atitle=Locomotion+in+restricted+space%3A+Kinematic+and+electromyographic+analysis+of+stoopwalking+and+crawling&rft.au=Gallagher%2C+Sean%3BPollard%2C+Jonisha%3BPorter%2C+William+L&rft.aulast=Gallagher&rft.aufirst=Sean&rft.date=2011-01-01&rft.volume=33&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Gait+%26+Posture&rft.issn=09666362&rft_id=info:doi/10.1016%2Fj.gaitpost.2010.09.027 LA - English DB - Physical Education Index N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Kinematics; Pace; Analysis; Knees; Electromyography; Work; Velocity; Legs; Gait DO - http://dx.doi.org/10.1016/j.gaitpost.2010.09.027 ER - TY - JOUR T1 - Potential immunotoxicological health effects following exposure to COREXIT 9500A during cleanup of the Deepwater Horizon oil spill. AN - 890671034; 21916747 AB - Workers involved in the Deepwater Horizon oil spill cleanup efforts reported acute pulmonary and dermatological adverse health effects. These studies were undertaken to assess the immunotoxicity of COREXIT 9500A, the primary dispersant used in cleanup efforts, as a potential causative agent. COREXIT 9500A and one of its active ingredients, dioctyl sodium sulfosuccinate (DSS), were evaluated using murine models for hypersensitivity and immune suppression, including the local lymph node assay (LLNA), phenotypic analysis of draining lymph node cells (DLN), mouse ear swelling test (MEST), total serum immunoglobulin E (IgE), and the plaque-forming cell (PFC) assay. Dermal exposure to COREXIT 9500A and DSS induced dose-responsive increases in dermal irritation and lymphocyte proliferation. The EC3 values for COREXIT 9500A and DSS were 0.4% and 3.9%, respectively, resulting in a classification of COREXIT 9500A as a potent sensitizer and DSS as a moderate sensitizer. A T-cell-mediated mechanism underlying the LLNA was supported by positive responses in the MEST assay for COREXIT and DSS, indicated by a significant increase in ear swelling 48 h post challenge. There were no marked alterations in total serum IgE or B220+/IgE+ lymph-node cell populations following exposure to COREXIT 9500A. Significant elevations in interferon (IFN)-γ but not interleukin (IL)-4 protein were also observed in stimulated lymph node cells. The absence of increases in IgE and IL-4 in the presence of enhanced lymphocyte proliferation, positive MEST responses, and elevations in IFN-γ suggest a T-cell-mediated mechanism. COREXIT 9500A did not induce immunosuppression in the murine model. JF - Journal of toxicology and environmental health. Part A AU - Anderson, Stacey E AU - Franko, Jennifer AU - Lukomska, Ewa AU - Meade, B J AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Sanderson4@cdc.gov Y1 - 2011 PY - 2011 DA - 2011 SP - 1419 EP - 1430 VL - 74 IS - 21 SN - 1528-7394, 1528-7394 KW - Cytokines KW - 0 KW - Emulsifying Agents KW - Lipids KW - corexit 9500 KW - Dioctyl Sulfosuccinic Acid KW - 10041-19-7 KW - Immunoglobulin E KW - 37341-29-0 KW - Index Medicus KW - Immune Tolerance -- drug effects KW - Animals KW - Immunoglobulin E -- blood KW - Immunologic Tests KW - Dioctyl Sulfosuccinic Acid -- toxicity KW - Mice KW - Cytokines -- metabolism KW - Mice, Inbred BALB C KW - Lymphocytes -- drug effects KW - Lymph Nodes -- drug effects KW - Gulf of Mexico KW - Female KW - Environmental Restoration and Remediation -- adverse effects KW - Emulsifying Agents -- toxicity KW - Petroleum Pollution KW - Lipids -- toxicity KW - Immune System Phenomena -- drug effects KW - Hypersensitivity -- etiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890671034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Potential+immunotoxicological+health+effects+following+exposure+to+COREXIT+9500A+during+cleanup+of+the+Deepwater+Horizon+oil+spill.&rft.au=Anderson%2C+Stacey+E%3BFranko%2C+Jennifer%3BLukomska%2C+Ewa%3BMeade%2C+B+J&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2011-01-01&rft.volume=74&rft.issue=21&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.606797 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-21 N1 - Date created - 2011-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287394.2011.606797 ER - TY - JOUR T1 - Pulmonary inflammation induced by office dust and the relation to 1 -> 3- Delta *b-glucan using different extraction techniques AN - 888108000; 15032724 AB - It is observed that 1 -> 3- Delta *b-glucan, a major cell wall component of fungi, induces pulmonary inflammation. There is inconsistency in determining the correlation between the levels of glucan measured by current extraction methods and the respiratory inflammation observed in individuals or lab animals exposed to environmental dust samples. The glucan-specific limulus amebocyte lysate (G-LAL) method was used after extraction with dimethyl sulfoxide (DMSO) or sodium hydroxide (NaOH) to analyze the glucan content of office dust samples collected from a water-damaged building. C3HeB/FeJ mice, an endotoxin-sensitive strain, were treated with different dust samples (2.5 mg kg-1 body weight) or saline (vehicle control) by pharyngeal aspiration. At 1 day after aspiration, bronchoalveolar lavage (BAL) was performed, and lung inflammation and injury were assessed by measuring: (1) neutrophil (PMN) infiltration, (2) inflammatory cytokine (IL-6, IL-10, MCP-1, IFN- Delta *g, TNF-a, and IL12-p70) levels, and (3) albumin and lactate dehydrogenase in recovered BAL fluid. Both DMSO and NaOH extraction increased the detection of glucan by approximately 20-fold compared to water extraction. However, only the DMSO extraction method showed a statistically significant positive correlation between 1 -> 3- Delta *b-glucan and albumin levels, total numbers of BAL, polymorphonuclear leukocytes (PMNs) cells recovered, levels of TNF-a, MCP-1, and IL-6. In conclusion, 1 -> 3- Delta *b-glucan is a potent inflammatory agent in dust samples and DMSO extraction for glucan analysis may prove useful in understanding the impact of environmental contamination by glucans on lung disease. JF - Toxicological and Environmental Chemistry AU - Young, Shih-Houng AU - Cox-Ganser, Jean M AU - Shogren, Elizabeth S AU - Wolfarth, Michael G AU - Li, Shengqiao AU - Antonini, James M AU - Castranova, Vincent AU - Park, Ju-Hyeong AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2011 PY - 2011 DA - 2011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 93 IS - 4 SN - 0277-2248, 0277-2248 KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amebocytes KW - Interleukin 6 KW - Pharynx KW - Contamination KW - Injuries KW - Leukocytes (polymorphonuclear) KW - Interleukin 1 KW - Statistical analysis KW - Interleukin 10 KW - Dust KW - Sodium hydroxide KW - Body weight KW - Bronchus KW - glucans KW - Monocyte chemoattractant protein 1 KW - Fungi KW - Leukocytes (neutrophilic) KW - Lung diseases KW - Alveoli KW - Inflammation KW - L-Lactate dehydrogenase KW - Lung KW - Albumin KW - Dimethyl sulfoxide KW - Tumor necrosis factor- alpha KW - Cell walls KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888108000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+and+Environmental+Chemistry&rft.atitle=Pulmonary+inflammation+induced+by+office+dust+and+the+relation+to+1+-%26gt%3B+3-+Delta+*b-glucan+using+different+extraction+techniques&rft.au=Young%2C+Shih-Houng%3BCox-Ganser%2C+Jean+M%3BShogren%2C+Elizabeth+S%3BWolfarth%2C+Michael+G%3BLi%2C+Shengqiao%3BAntonini%2C+James+M%3BCastranova%2C+Vincent%3BPark%2C+Ju-Hyeong&rft.aulast=Young&rft.aufirst=Shih-Houng&rft.date=2011-01-01&rft.volume=93&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicological+and+Environmental+Chemistry&rft.issn=02772248&rft_id=info:doi/10.1080%2F02772248.2011.554229 L2 - http://www.informaworld.com/smpp/content~db=all~content=a933408538~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Amebocytes; Pharynx; Injuries; Contamination; Leukocytes (polymorphonuclear); Interleukin 1; Statistical analysis; Dust; Interleukin 10; Sodium hydroxide; Bronchus; Body weight; glucans; Monocyte chemoattractant protein 1; Fungi; Lung diseases; Leukocytes (neutrophilic); Alveoli; L-Lactate dehydrogenase; Inflammation; Lung; Albumin; Dimethyl sulfoxide; Tumor necrosis factor- alpha; Cell walls DO - http://dx.doi.org/10.1080/02772248.2011.554229 ER - TY - JOUR T1 - Raw single-walled carbon nanotube-induced cytotoxic effects in human bronchial epithelial cells: comparison to asbestos AN - 888095345; 15032743 AB - Single-walled carbon nanotubes (SWCNT) are being developed to be used in many industrial and biomedical applications. However, SWCNT's durability and likely fibrous morphology have raised health concerns. The present investigations were focused on understanding the cellular and molecular mechanisms induced by raw SWCNT (SWCNT) in human bronchial-epithelial cells (BEAS-2B). Asbestos (crocidolite) was used as a positive control. Exposure of BEAS-2B cells to SWCNT induced apoptosis, DNA damage, and oxidative stress. The generation of hydroxyl radical (-OH) and increase of superoxide dismutase (SOD) activity were concentration-dependent. The increase in apoptosis was associated with activation of caspase-3, caspase-7, and poly (ADP-ribose) polymerase-1 (PARP-1). A short recovery period of 6 h of cells from SWCNT exposure resulted in reversal of caspase-3 and caspase-7, and a partial reversal of PARP-1 activation. The activation of PARP-1, caspase-3, and caspase-7 was only partially diminished after a recovery of 6 h from the exposure to crocidolite. Exposure of BEAS-2B cells to SWCNT resulted in the phosphorylation of protein p42/44 (p42/44) and protein p38 (p38). SWCNT did not induce protein serine-threonine kinase (AKT) phosphorylation. For all the above end points, crocidolite induced a greater response compared to SWCNT. SWCNT induced a significant activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF- Delta *kB), and the effect was inhibited by mitogen-activated protein kinase (MAPK) inhibitors. SWCNT also induced significant increase in the expression levels of c-Jun, Delta *bIGH3, and CD44 genes. The results of this study show that the molecular mechanism for raw SWCNT-mediated toxicity in BEAS-2B cells is through the activation of caspase-3, caspase-7, and PARP-1. Furthermore, the mechanism of AP-1 and NF- Delta *kB activation is through MAPK. This bioactivity of raw SWCNT is associated with the generation of oxidative stress and DNA damage. Considering the role of airway epithelium as a critical barrier for normal pulmonary function and focal point for tumor development, this study demonstrates that raw SWCNT activate molecular events which may be linked to adverse biological responses implicated in pulmonary diseases. JF - Toxicological and Environmental Chemistry AU - Pacurari, Maricica AU - Schwegler-Berry, Diane AU - Friend, Sherri AU - Leonard, Steven S AU - Mercer, Robert R AU - Vallyathan, Val AU - Castranova, Vincent AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2011 PY - 2011 DA - 2011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 93 IS - 5 SN - 0277-2248, 0277-2248 KW - Toxicology Abstracts KW - Molecular modelling KW - Epithelial cells KW - Asbestos KW - MAP kinase KW - Apoptosis KW - poly(ADP-ribose) polymerase 1 KW - Free radicals KW - Activator protein 1 KW - Caspase-7 KW - Crocidolite KW - Toxicity KW - DNA damage KW - Carbon KW - Phosphorylation KW - Oxidative stress KW - Superoxide dismutase KW - Transcription factors KW - Caspase-3 KW - Respiratory tract KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888095345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+and+Environmental+Chemistry&rft.atitle=Raw+single-walled+carbon+nanotube-induced+cytotoxic+effects+in+human+bronchial+epithelial+cells%3A+comparison+to+asbestos&rft.au=Pacurari%2C+Maricica%3BSchwegler-Berry%2C+Diane%3BFriend%2C+Sherri%3BLeonard%2C+Steven+S%3BMercer%2C+Robert+R%3BVallyathan%2C+Val%3BCastranova%2C+Vincent&rft.aulast=Pacurari&rft.aufirst=Maricica&rft.date=2011-01-01&rft.volume=93&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicological+and+Environmental+Chemistry&rft.issn=02772248&rft_id=info:doi/10.1080%2F02772248.2011.571530 L2 - http://www.informaworld.com/smpp/content~db=all~content=a937792821~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Molecular modelling; MAP kinase; Asbestos; Apoptosis; poly(ADP-ribose) polymerase 1; Free radicals; Caspase-7; Activator protein 1; Crocidolite; Toxicity; DNA damage; Carbon; Phosphorylation; Superoxide dismutase; Oxidative stress; Transcription factors; Caspase-3; Respiratory tract DO - http://dx.doi.org/10.1080/02772248.2011.571530 ER - TY - JOUR T1 - Blockade of brain angiotensin II AT sub(1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications) AN - 883041038; 15329287 AB - Poor adaptation to stress, alterations in cerebrovascular function and excessive brain inflammation play critical roles in the pathophysiology of many psychiatric and neurological disorders such as major depression, schizophrenia, post traumatic stress disorder, Parkinson's and Alzheimer's diseases and traumatic brain injury. Treatment for these highly prevalent and devastating conditions is at present very limited and many times inefficient, and the search for novel therapeutic options is of major importance. Recently, attention has been focused on the role of a brain regulatory peptide, Angiotensin, and in the translational value of the blockade of its physiological AT sub(1 receptors. In addition to its well-known cardiovascular effects, Angiotensin, through AT) sub(1) receptor stimulation, is a pleiotropic brain modulatory factor involved in the control of the reaction to stress, in the regulation of cerebrovascular flow and the response to inflammation. Excessive brain AT sub(1 receptor activity is associated with exaggerated sympathetic and hormonal response to stress, vulnerability to cerebrovascular ischemia and brain inflammation, processes leading to neuronal injury. In animal models, inhibition of brain AT) sub(1) receptor activity with systemically administered Angiotensin II receptor blockers is neuroprotective; it reduces exaggerated stress responses and anxiety, prevents stress-induced gastric ulcerations, decreases vulnerability to ischemia and stroke, reverses chronic cerebrovascular inflammation, and reduces acute inflammatory responses produced by bacterial endotoxin. These effects protect neurons from injury and contribute to increase the lifespan. Angiotensin II receptor blockers are compounds with a good margin of safety widely used in the treatment of hypertension and their anti-inflammatory and vascular protective effects contribute to reduce renal and cardiovascular failure. Inhibition of brain AT sub(1 receptors in humans is also neuroprotective, reducing the incidence of stroke, improving cognition and decreasing the progression of Alzheimer's disease. Blockade of AT) sub(1) receptors offers a novel and safe therapeutic approach for the treatment of illnesses of increasing prevalence and socioeconomic impact, such as mood disorders and neurodegenerative diseases of the brain. JF - Psychoneuroendocrinology AU - Saavedra, Juan M AU - Sanchez-Lemus, Enrique AU - Benicky, Julius AD - Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 10 Center Drive, Building 10, Room 2D-57, Bethesda, MD 20892, United States, Saavedrj@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 1 EP - 18 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 36 IS - 1 SN - 0306-4530, 0306-4530 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Endotoxins KW - Translation KW - Neurological diseases KW - Anxiety KW - Parkinson's disease KW - Alzheimer's disease KW - Animal models KW - Neuroprotection KW - Angiotensin KW - Cognition KW - Mood KW - Schizophrenia KW - Mental disorders KW - Angiotensin II receptors KW - Traumatic brain injury KW - Adaptations KW - Life span KW - Stroke KW - Brain KW - Stress KW - Renal failure KW - Ischemia KW - Angiotensin II KW - Inflammation KW - Socio-economic aspects KW - Neurodegenerative diseases KW - Movement disorders KW - Kidney KW - Attention KW - Hypertension KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883041038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=Blockade+of+brain+angiotensin+II+AT+sub%281+receptors+ameliorates+stress%2C+anxiety%2C+brain+inflammation+and+ischemia%3A+Therapeutic+implications%29&rft.au=Saavedra%2C+Juan+M%3BSanchez-Lemus%2C+Enrique%3BBenicky%2C+Julius&rft.aulast=Saavedra&rft.aufirst=Juan&rft.date=2011-01-01&rft.volume=36&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=03064530&rft_id=info:doi/10.1016%2Fj.psyneuen.2010.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Endotoxins; Translation; Neurological diseases; Anxiety; Parkinson's disease; Alzheimer's disease; Animal models; Neuroprotection; Angiotensin; Cognition; Schizophrenia; Mood; Mental disorders; Angiotensin II receptors; Traumatic brain injury; Adaptations; Stroke; Life span; Brain; Renal failure; Stress; Ischemia; Angiotensin II; Inflammation; Neurodegenerative diseases; Socio-economic aspects; Movement disorders; Kidney; Attention; Hypertension DO - http://dx.doi.org/10.1016/j.psyneuen.2010.10.001 ER - TY - RPRT T1 - Pathways and Partnerships for Child Care Excellence AN - 881453131; ED520491 AB - More than 12 million American children regularly rely on child care to support their healthy development and school success. Of these, over 1.6 million children receive a child care subsidy from the Child Care and Development Fund (CCDF) program each month. In addition, CCDF helps leverage child care investments from the Temporary Assistance for Needy Families (TANF) program and other funding streams, resulting in financial support to make child care more affordable for a total of 2.5 million children each month. Each year, CCDF invests over $5 billion ($7 billion in 2009 from the American Recovery and Reinvestment Act), plus additional funds transferred from TANF to CCDF. States, Territories, and Tribes annually spend $1 billion to support child care quality improvement, resulting in better learning environments and more effective caregivers in child care centers and family child care homes across the country. At the U.S. Department of Health and Human Services (HHS), the Administration for Children and Families (ACF) is pursuing a comprehensive approach to helping more children in low-income families access high-quality care. ACF's Office of Child Care (OCC) administers the CCDF and works with State, Territory, and Tribal governments to provide strong support for children and their families as they juggle work schedules and struggle to find affordable, high-quality child care for their children. This paper provides details on the following: (1) Pathways to Excellence for Child Care Programs; (2) Pathways to Excellence for Child Care Professionals; and (3) Pathways to Stronger Policies and Accountability. (Contains 1 footnote.) Y1 - 2011 PY - 2011 DA - 2011 SP - 6 PB - Office of Child Care. US Department of Health and Human Services, Administration for Children and Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - Temporary Assistance for Needy Families KW - Child Care and Development Block Grants KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Financial Support KW - Low Income Groups KW - Policy KW - Child Caregivers KW - Child Health KW - Standards KW - Professional Development KW - Improvement KW - Child Care KW - Accountability KW - Child Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881453131?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Regulatory Approaches to Worker Protection in Nanotechnology Industry in the USA and European Union AN - 874197206; 15001588 AB - A number of reports have been published regarding the applicability of existing regulatory frameworks to protect consumers and the environment from potentially adverse effects related to introduction of nanomaterials into commerce in the United States and the European Union. However, a detailed comparison of the regulatory approaches to worker safety and health in the USA and in the EU is lacking. This report aims to fill this gap by reviewing regulatory frameworks designed to protect workers and their possible application to nanotechnology. JF - Industrial Health AU - Murashov, Vladimir AU - Schulte, Paul AU - Geraci, Charles AU - Howard, John AD - National Institute for Occupational Safety and Health Y1 - 2011 PY - 2011 DA - 2011 SP - 280 EP - 296 PB - National Institute of Industrial Health. Japan., 21-1 Nagao 6-chome Kawasaki-shi 214-0023 Kanagawa-ken Japan VL - 49 IS - 3 SN - 1880-8026, 1880-8026 KW - Health & Safety Science Abstracts; Risk Abstracts KW - USA KW - European Union KW - consumer protection KW - Side effects KW - nanotechnology KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874197206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Regulatory+Approaches+to+Worker+Protection+in+Nanotechnology+Industry+in+the+USA+and+European+Union&rft.au=Murashov%2C+Vladimir%3BSchulte%2C+Paul%3BGeraci%2C+Charles%3BHoward%2C+John&rft.aulast=Murashov&rft.aufirst=Vladimir&rft.date=2011-01-01&rft.volume=49&rft.issue=3&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=18808026&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - consumer protection; Side effects; nanotechnology; USA; European Union ER - TY - JOUR T1 - Induction of apoptosis and CYP4A1 expression in Sprague-Dawley rats exposed to low doses of perfluorooctane sulfonate AN - 872137860; 14914846 AB - In previous studies, perfluorooctane sulfonate (PFOS), an environmental organic compound, was reported to cause hepatotoxicity and hypolipidemia in rodents. However, the low dose toxicity of PFOS and the toxic mechanisms involved remain to be determined. To clarify the low dose toxicity and action mechanism in the target organ toxicity, Sprague-Dawley (SD) rats were orally administered with PFOS at the doses of 0, 1.25, 5, 10 mg/kg/day for 28 days. As a result, no death or abnormal symptoms were observed in all groups. The significant loss of mean body weight was observed in female rats treated with 10 mg/kg PFOS and the relative liver weight of 10 mg/kg PFOS-treated group was significantly greater compared to control. Histopathological examination revealed that fatty change was evident in the liver of male rats treated with PFOS (5 and 10 mg/kg) and hypertrophy and cellular swellings in females at the dose of 10 mg/kg, which showed different pattern of pathological lesions. In addition, we demonstrated the expression induction of hepatic caspase-3 and cytochrome P450 4A1 (CYP4A1) related with apoptosis and lipid metabolism, respectively. This study suggested that no-observed-adverse-effect level (NOAEL) of PFOS was 1.25 mg/kg in 28-day repeated toxicity study and, however, the toxic response showed gender differences. The possible toxic mechanism of PFOS was the induction of apoptosis and altering lipid metabolism which resulted in hepatotoxicity. JF - Journal of Toxicological Sciences AU - Kim, Hyung-Sub AU - Kwack, Seung Jun AU - Han, Eui Sik AU - Kang, Tae Seok AU - Kim, Seung Hee AU - Han, Soon Young AD - Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Osong Health Technology Administrstion Complex Y1 - 2011 PY - 2011 DA - 2011 SP - 201 EP - 210 PB - Japanese Society of Toxicological Sciences, Gakkai CTR Bldg 4th Fl, 2-4-16 Yayoi Bunkyo-ku, Tokyo 113-0032 Japan VL - 36 IS - 2 SN - 1880-3989, 1880-3989 KW - Environment Abstracts; Toxicology Abstracts KW - sulfonates KW - Apoptosis KW - Lipids KW - Sex differences KW - Rats KW - Body weight KW - body weight KW - Mortality KW - Oral administration KW - Toxicity KW - hepatotoxicity KW - Lipid metabolism KW - Hypertrophy KW - Liver KW - Caspase-3 KW - Cytochrome P450 KW - Organic compounds KW - Metabolism KW - X 24350:Industrial Chemicals KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872137860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicological+Sciences&rft.atitle=Induction+of+apoptosis+and+CYP4A1+expression+in+Sprague-Dawley+rats+exposed+to+low+doses+of+perfluorooctane+sulfonate&rft.au=Kim%2C+Hyung-Sub%3BKwack%2C+Seung+Jun%3BHan%2C+Eui+Sik%3BKang%2C+Tae+Seok%3BKim%2C+Seung+Hee%3BHan%2C+Soon+Young&rft.aulast=Kim&rft.aufirst=Hyung-Sub&rft.date=2011-01-01&rft.volume=36&rft.issue=2&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicological+Sciences&rft.issn=18803989&rft_id=info:doi/10.2131%2Fjts.36.201 L2 - http://www.jstage.jst.go.jp/article/jts/36/2/201/_pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Hypertrophy; Apoptosis; Body weight; Caspase-3; Oral administration; Liver; Organic compounds; Cytochrome P450; Toxicity; Sex differences; hepatotoxicity; Lipid metabolism; Rats; Mortality; sulfonates; Lipids; body weight; Metabolism DO - http://dx.doi.org/10.2131/jts.36.201 ER - TY - JOUR T1 - A method to determine the available UV-C dose for the decontamination of filtering facepiece respirators AN - 872130729; 14194585 JF - Journal of Applied Microbiology AU - Fisher, E M AU - Shaffer, R E AD - National Institute for Occupational Safety and Health, National Personal Protective, Technology Laboratory, Pittsburgh, PA, USA Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 287 EP - 295 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 110 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology KW - Decontamination KW - Respirators KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872130729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=A+method+to+determine+the+available+UV-C+dose+for+the+decontamination+of+filtering+facepiece+respirators&rft.au=Fisher%2C+E+M%3BShaffer%2C+R+E&rft.aulast=Fisher&rft.aufirst=E&rft.date=2011-01-01&rft.volume=110&rft.issue=1&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2010.04881.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Document feature - figure 2 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Decontamination; Respirators DO - http://dx.doi.org/10.1111/j.1365-2672.2010.04881.x ER - TY - JOUR T1 - The business cycle and the incidence of workplace injuries: Evidence from the U.S.A. AN - 867737123; 14602326 AB - The current study explored the association between the business cycle and the incidence of workplace injuries to identify cyclically sensitive industries and the relative contribution of physical capital and labor utilization within industries. Method: Bureau of Labor Statistics nonfatal injury rates from 1976 through 2007 were examined across five industry sectors with respect to several macroeconomic indicators. Within industries, injury associations with utilization of labor and physical capital over time were tested using time series regression methods. Results: Pro-cyclical associations between business cycle indicators and injury incidence were observed in mining, construction, and manufacturing but not in agriculture or trade. Physical capital utilization was the highest potential contributor to injuries in mining while labor utilization was the highest potential contributor in construction. In manufacturing each effect had a similar association with injuries. Conclusion: The incidence of workplace injury is associated with the business cycle. However, the degree of association and the mechanisms through with the business cycle affects the incidence of workplace injuries was not the same across industries. Impact on Industry: The results suggest that firms in the construction, manufacturing, and mining industries should take additional precautionary safety measures during cyclical upturns. Potential differences among industries in the mechanisms through which the business cycle affects injury incidence suggest different protective strategies for those industries. For example, in construction, additional efforts might be undertaken to ensure workers are adequately trained and not excessively fatigued, while safety procedures continue to be followed even during boom times. Research Highlights: Workplace injuries in mining, construction, and manufacturing sectors but not in agriculture or trade were sensitive to the business. The mechanism through which the business cycle affects the incidence of workplace injuries was not the same across different industries. Physical capital utilization was the highest potential contributor to injuries in mining while labor utilization was the highest potential contributor in construction. In manufacturing each effect had a similar association with injuries. This indicates the need for considering different prevention strategies in different industries. JF - Journal of Safety Research AU - Asfaw, Abay AU - Pana-Cryan, Regina AU - Rosa, Roger AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Office of the Director, Washington, DC Y1 - 2011 PY - 2011 DA - 2011 SP - 1 EP - 8 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 42 IS - 1 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - business cycles KW - Manufacturing industry KW - Injuries KW - time series analysis KW - agriculture KW - prevention KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867737123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=The+business+cycle+and+the+incidence+of+workplace+injuries%3A+Evidence+from+the+U.S.A.&rft.au=Asfaw%2C+Abay%3BPana-Cryan%2C+Regina%3BRosa%2C+Roger&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2011-01-01&rft.volume=42&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Manufacturing industry; business cycles; Injuries; time series analysis; prevention; agriculture; Mining DO - http://dx.doi.org/10.1016/j.jsr.2010.10.008 ER - TY - JOUR T1 - Simultaneous Analysis of Multiple Enzymes Increases Accuracy of Pulsed-Field Gel Electrophoresis in Assigning Genetic Relationships among Homogeneous Salmonella Strains AN - 860384466; 14169763 AB - Due to a highly homogeneous genetic composition, the subtyping of Salmonella enterica serovar Enteritidis strains to an epidemiologically relevant level remains intangible for pulsed-field gel electrophoresis (PFGE). We reported previously on a highly discriminatory PFGE-based subtyping scheme for S. enterica serovar Enteritidis that relies on a single combined cluster analysis of multiple restriction enzymes. However, the ability of a subtyping method to correctly infer genetic relatedness among outbreak strains is also essential for effective molecular epidemiological traceback. In this study, genetic and phylogenetic analyses were performed to assess whether concatenated enzyme methods can cluster closely related salmonellae into epidemiologically relevant hierarchies. PFGE profiles were generated by use of six restriction enzymes (XbaI, BlnI, SpeI, SfiI, PacI, and NotI) for 74 strains each of S. enterica serovar Enteritidis and S. enterica serovar Typhimurium. Correlation analysis of Dice similarity coefficients for all pairwise strain comparisons underscored the importance of combining multiple enzymes for the accurate assignment of genetic relatedness among Salmonella strains. The mean correlation increased from 81% and 41% for single-enzyme PFGE up to 99% and 96% for five-enzyme combined PFGE for S. enterica serovar Enteritidis and S. enterica serovar Typhimurium strains, respectively. Data regressions approached 100% correlation among Dice similarities for S. enterica serovar Enteritidis and S. enterica serovar Typhimurium strains when a minimum of six enzymes were concatenated. Phylogenetic congruence measures singled out XbaI, BlnI, SfiI, and PacI as most concordant for S. enterica serovar Enteritidis, while XbaI, BlnI, and SpeI were most concordant among S. enterica serovar Typhimurium strains. Together, these data indicate that PFGE coupled with sufficient enzyme numbers and combinations is capable of discerning accurate genetic relationships among Salmonella serovars comprising highly homogeneous strain complexes. JF - Journal of Clinical Microbiology AU - Zheng, Jie AU - Keys, Christine E AU - Zhao, Shaohua AU - Ahmed, Rafiq AU - Meng, Jianghong AU - Brown, Eric W AD - Center for Food Safety & Applied Nutrition, U.S. Food & Drug Administration, College Park, Maryland 20740. Center for Veterinary Medicine, U.S. Food & Drug Administration, Laurel, Maryland 20708. National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada. Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742 Y1 - 2011 PY - 2011 DA - 2011 SP - 85 EP - 94 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 49 IS - 1 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Genetic relationship KW - Data processing KW - Salmonella enterica KW - Pulsed-field gel electrophoresis KW - Enzymes KW - Correlation analysis KW - Salmonella KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860384466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Simultaneous+Analysis+of+Multiple+Enzymes+Increases+Accuracy+of+Pulsed-Field+Gel+Electrophoresis+in+Assigning+Genetic+Relationships+among+Homogeneous+Salmonella+Strains&rft.au=Zheng%2C+Jie%3BKeys%2C+Christine+E%3BZhao%2C+Shaohua%3BAhmed%2C+Rafiq%3BMeng%2C+Jianghong%3BBrown%2C+Eric+W&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2011-01-01&rft.volume=49&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Genetic relationship; Phylogeny; Data processing; Pulsed-field gel electrophoresis; Enzymes; Correlation analysis; Salmonella enterica; Salmonella ER - TY - JOUR T1 - Solid core column technology applied to HPLC-FD of paralytic shellfish toxins AN - 860381973; 14371109 AB - Pre-column oxidation liquid chromatography with fluorescence detection is a chemical method for analyzing paralytic shellfish toxins. In order to improve the sample throughput and efficiency of AOAC Method 2005.06, solid core particle column technology was evaluated. We demonstrate that supplanting the original fully porous particle column with a solid core particle column reduces sample analysis time from 15 to 5min per sample and improves resolution. JF - Toxicon AU - DeGrasse, Stacey L AU - DeGrasse, Jeffrey A AU - Reuter, Kevin AD - US FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 179 EP - 182 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 57 IS - 1 SN - 0041-0101, 0041-0101 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Column KW - HPLC KW - Oxidation KW - Paralytic shellfish toxins KW - Saxitoxin KW - Solid core KW - Fused core KW - Fluorescence KW - Toxicants KW - Liquid chromatography KW - Chromatographic techniques KW - Core particles KW - Shellfish KW - Toxins KW - Q1 08485:Species interactions: pests and control KW - X 24360:Metals KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860381973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Solid+core+column+technology+applied+to+HPLC-FD+of+paralytic+shellfish+toxins&rft.au=DeGrasse%2C+Stacey+L%3BDeGrasse%2C+Jeffrey+A%3BReuter%2C+Kevin&rft.aulast=DeGrasse&rft.aufirst=Stacey&rft.date=2011-01-01&rft.volume=57&rft.issue=1&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Toxicants; Chromatographic techniques; Shellfish; Fluorescence; Liquid chromatography; Core particles; Oxidation; Toxins DO - http://dx.doi.org/10.1016/j.toxicon.2010.11.004 ER - TY - JOUR T1 - Detection of mycoplasma contamination in cell substrates using reverse transcription-PCR assays AN - 858423346; 14194594 JF - Journal of Applied Microbiology AU - Peredeltchouk, M AU - Wilson David, SA AU - Bhattacharya, B AU - Volokhov, D V AU - Chizhikov, V AD - Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 54 EP - 60 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 110 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology KW - Contamination KW - Mycoplasma KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/858423346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Detection+of+mycoplasma+contamination+in+cell+substrates+using+reverse+transcription-PCR+assays&rft.au=Peredeltchouk%2C+M%3BWilson+David%2C+SA%3BBhattacharya%2C+B%3BVolokhov%2C+D+V%3BChizhikov%2C+V&rft.aulast=Peredeltchouk&rft.aufirst=M&rft.date=2011-01-01&rft.volume=110&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2010.04853.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Document feature - figure 3 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Contamination; Mycoplasma DO - http://dx.doi.org/10.1111/j.1365-2672.2010.04853.x ER - TY - JOUR T1 - Evaluating the Protective Capacity of Two-Post ROPS for a Seat-Belted Occupant During a Farm Tractor Overturn AN - 856786244; 14408319 AB - This study evaluated the effectiveness of a commercial rollover protective structure (ROPS) and size-extended ROPS in protecting a 95th percentile male operator during tractor overturns. Six rear upset tests (commercial ROPS) and ten side upset tests (commercial and size-extended ROPS) were conducted. A 95th percentile instrumented male manikin was used in all tests. Head injury criterion (HIC sub(15)), 80 g limit on resultant head acceleration, neck injury criterion (N sub(ij)), and peak axial force (extension-compression) were employed to evaluate injury potential. In all rear tests, the manikin's head impact with the ground was within the tolerance limits for head/neck injuries. Based on limited trials in the side tests, the study observed a small to moderate chance of neck injuries under the commercial and size-extended ROPS conditions; the injury risk was not statistically significant between these two test conditions. This study identified a risk of non-fatal injuries for large-size operators in side overturns, although the prevention effectiveness of commercial versus size-extended ROPS cannot be determined without further testing. These findings may have implications for future ROPS designs. JF - Journal of Agricultural Safety and Health AU - Guan, J AU - Hsiao, H AU - Zwicner, J V AU - Current, R S AU - Lutz, T J AU - Cantis, D M AU - Powers, JR Jr AU - Newbraugh, B H AU - Spahr, J S AD - NIOSH Division of Safety Research, 1095 Willowdalc Road, MS G800, Morgantown, WV 26505, USA, czg6@cdc.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 15 EP - 32 VL - 17 IS - 1 SN - 1074-7583, 1074-7583 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - farms KW - neck injuries KW - prevention KW - head injuries KW - rollover KW - Agricultural equipment KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856786244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Evaluating+the+Protective+Capacity+of+Two-Post+ROPS+for+a+Seat-Belted+Occupant+During+a+Farm+Tractor+Overturn&rft.au=Guan%2C+J%3BHsiao%2C+H%3BZwicner%2C+J+V%3BCurrent%2C+R+S%3BLutz%2C+T+J%3BCantis%2C+D+M%3BPowers%2C+JR+Jr%3BNewbraugh%2C+B+H%3BSpahr%2C+J+S&rft.aulast=Guan&rft.aufirst=J&rft.date=2011-01-01&rft.volume=17&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Injuries; farms; head injuries; prevention; neck injuries; rollover; Agricultural equipment ER - TY - JOUR T1 - Silymarin use and liver disease progression in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial AN - 856778588; 14191996 AB - Background: Silymarin is the most commonly used herbal product for chronic liver disease; yet, whether silymarin protects against liver disease progression remains unclear. Aim: To assess the effects of silymarin use on subsequent liver disease progression in 1049 patients of the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis (HALT-C) trial who had advanced fibrosis or cirrhosis and had failed prior peginterferon plus ribavirin treatment. Methods: Patients recorded their use of silymarin at baseline and were followed up for liver disease progression (two point increase in Ishak fibrosis score across baseline, year 1.5, and year 3.5 biopsies) and over 8.65years for clinical outcomes. Results: At baseline, 34% of patients had used silymarin, half of whom were current users. Use of silymarin was associated (P<0.05) with male gender; oesophageal varices; higher ALT and albumin; and lower AST/ALT ratio, among other features. Baseline users had less hepatic collagen content on study biopsies and had less histological progression (HR: 0.57, 95% CI: 0.33-1.00; P-trend for longer duration of use=0.026). No effect was seen for clinical outcomes. Conclusions: Silymarin use among patients with advanced hepatitis C-related liver disease is associated with reduced progression from fibrosis to cirrhosis, but has no impact on clinical outcomes. JF - Alimentary Pharmacology and Therapeutics AU - Freedman, N D AU - Curto, T M AU - Morishima, C AU - Seeff, L B AU - Goodman, Z D AU - Wright, E C AU - Sinha, R AU - Everhart, JE AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. Y1 - 2011/01// PY - 2011 DA - Jan 2011 SP - 127 EP - 137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 33 IS - 1 SN - 0269-2813, 0269-2813 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Albumin KW - Biopsy KW - Cirrhosis KW - Clinical trials KW - Collagen (type I) KW - Esophagus KW - Fibrosis KW - Hepatitis C KW - Liver diseases KW - Ribavirin KW - silymarin KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856778588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alimentary+Pharmacology+and+Therapeutics&rft.atitle=Silymarin+use+and+liver+disease+progression+in+the+Hepatitis+C+Antiviral+Long-Term+Treatment+against+Cirrhosis+trial&rft.au=Freedman%2C+N+D%3BCurto%2C+T+M%3BMorishima%2C+C%3BSeeff%2C+L+B%3BGoodman%2C+Z+D%3BWright%2C+E+C%3BSinha%2C+R%3BEverhart%2C+JE&rft.aulast=Freedman&rft.aufirst=N&rft.date=2011-01-01&rft.volume=33&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Alimentary+Pharmacology+and+Therapeutics&rft.issn=02692813&rft_id=info:doi/10.1111%2Fj.1365-2036.2010.04503.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Document feature - figure 2 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Esophagus; Cirrhosis; Liver diseases; Fibrosis; Albumin; Ribavirin; Biopsy; silymarin; Hepatitis C; Collagen (type I); Clinical trials DO - http://dx.doi.org/10.1111/j.1365-2036.2010.04503.x ER - TY - JOUR T1 - Role of Purine Biosynthesis in Bacillus anthracis Pathogenesis and Virulence AN - 856774921; 14156571 AB - Bacillus anthracis, the etiological agent of anthrax, is a spore-forming, Gram-positive bacterium and a category A biothreat agent. Screening of a library of transposon-mutagenized B. anthracis spores identified a mutant displaying an altered phenotype that harbored a mutated gene encoding the purine biosynthetic enzyme PurH. PurH is a bifunctional protein that catalyzes the final steps in the biosynthesis of the purine IMP. We constructed and characterized defined purH mutants of the virulent B. anthracis Ames strain. The virulence of the purH mutants was assessed in guinea pigs, mice, and rabbits. The spores of the purH mutants were as virulent as wild-type spores in mouse intranasal and rabbit subcutaneous infection models but were partially attenuated in a mouse intraperitoneal model. In contrast, the purH mutant spores were highly attenuated in guinea pigs regardless of the administration route. The reduced virulence in guinea pigs was not due solely to a germination defect, since both bacilli and toxins were detected in vivo, suggesting that the significant attenuation was associated with a growth defect in vivo. We hypothesize that an intact purine biosynthetic pathway is required for the virulence of B. anthracis in guinea pigs. JF - Infection and Immunity AU - Jenkins, Amy AU - Cote, Christopher AU - Twenhafel, Nancy AU - Merkel, Tod AU - Bozue, Joel AU - Welkos, Susan AD - Bacteriology Division. Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick. Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, CBER, FDA, Bethesda, Maryland Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 153 EP - 166 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 79 IS - 1 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts; Immunology Abstracts KW - Germination KW - Bacilli KW - Inosine monophosphate KW - Animal models KW - Enzymes KW - Bacillus anthracis KW - Infection KW - purines KW - Toxins KW - Virulence KW - Anthrax KW - Spores KW - J 02410:Animal Diseases KW - N 14840:Antisense, Nucleotide Analogs KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856774921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Role+of+Purine+Biosynthesis+in+Bacillus+anthracis+Pathogenesis+and+Virulence&rft.au=Jenkins%2C+Amy%3BCote%2C+Christopher%3BTwenhafel%2C+Nancy%3BMerkel%2C+Tod%3BBozue%2C+Joel%3BWelkos%2C+Susan&rft.aulast=Jenkins&rft.aufirst=Amy&rft.date=2011-01-01&rft.volume=79&rft.issue=1&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Germination; Virulence; Bacilli; Inosine monophosphate; Animal models; Enzymes; Anthrax; Infection; Spores; Toxins; purines; Bacillus anthracis ER - TY - JOUR T1 - Recession Contributes To Slowest Annual Rate Of Increase In Health Spending In Five Decades AN - 856399960; 2011-50283 AB - In 2009, US health care spending grew 4.0 percent-a historically low rate of annual increase-to $2.5 trillion, or $8,086 per person. Despite the slower growth, the share of the gross domestic product devoted to health spending increased to 17.6 percent in 2009 from 16.6 percent in 2008. The growth rate of health spending continued to outpace the growth of the overall economy, which experienced its largest drop since 1938. The recession contributed to slower growth in private health insurance spending and out-of-pocket spending by consumers, as well as a reduction in capital investments by health care providers. The recession also placed increased burdens on households, businesses, and governments, which meant that fewer financial resources were available to pay for health care. Declining federal revenues and strong growth in federal health spending increased the health spending share of total federal revenue from 37.6 percent in 2008 to 54.2 percent in 2009. Adapted from the source document. JF - Health Affairs AU - Martin, Anne AU - Lassman, David AU - Whittle, Lekha AU - Catlin, Aaron AD - National Health Expenditure Accounts Team, Office of the Actuary, Centers for Medicare and Medicaid Services, Baltimore, Maryland anne.martin@cms.hhs.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 11 EP - 22 PB - Project HOPE, Bethesda MD VL - 30 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Economic theory KW - Economic conditions and policy - Economic conditions KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Population groups, population policy, and demographics - Demography and census KW - Banking and public and private finance - Public finance KW - United States KW - Cost KW - Business conditions KW - Households KW - Health insurance KW - Revenue KW - Economic conditions KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856399960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Recession+Contributes+To+Slowest+Annual+Rate+Of+Increase+In+Health+Spending+In+Five+Decades&rft.au=Martin%2C+Anne%3BLassman%2C+David%3BWhittle%2C+Lekha%3BCatlin%2C+Aaron&rft.aulast=Martin&rft.aufirst=Anne&rft.date=2011-01-01&rft.volume=30&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.1032 LA - English DB - PAIS Index N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical service; Cost; Economic conditions; United States; Business conditions; Health insurance; Revenue; Households DO - http://dx.doi.org/10.1377/hlthaff.2010.1032 ER - TY - JOUR T1 - Building A Stronger Foundation For A New Century Of Treatments And Cures AN - 856399948; 2011-50290 AB - In the past two years, the United States has made a historic investment in biomedical research. But innovative medicines often stall in the pipeline from microscope to market. To deliver the next generation of cures and treatments to help Americans live longer, healthier, and more comfortable lives, strong, strategic partnerships both within government and among government, academe, industry, and nonprofits are needed at every stage of drug development. In this article I describe actual and potential efforts on the part of the US government-including the Biomarkers Consortium and National Institutes of Health Therapeutics for Rare and Neglected Diseases program-to work with other stakeholders to advance biomedical research and development. Adapted from the source document. JF - Health Affairs AU - Sebelius, Kathleen AD - US Department of Health and Human Services, Washington, DC healthcare@hhs.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 81 EP - 83 PB - Project HOPE, Bethesda MD VL - 30 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Business and service sector - Business and business enterprises KW - Science and technology policy - Science and science policy and research KW - Health conditions and policy - Diseases and disorders KW - Manufacturing and heavy industry - Pharmaceutical industry KW - United States KW - Corporations, Nonprofit KW - Research and development KW - Medical research KW - Medicine KW - Diseases KW - Drugs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856399948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Building+A+Stronger+Foundation+For+A+New+Century+Of+Treatments+And+Cures&rft.au=Sebelius%2C+Kathleen&rft.aulast=Sebelius&rft.aufirst=Kathleen&rft.date=2011-01-01&rft.volume=30&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0995 LA - English DB - PAIS Index N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Medical research; United States; Corporations, Nonprofit; Research and development; Medicine; Diseases; Drugs DO - http://dx.doi.org/10.1377/hlthaff.2010.0995 ER - TY - JOUR T1 - Strengthening the U.S. Vaccine and Immunization Enterprise: The Role of the National Vaccine Advisory Committee AN - 856399324; 2011-47292 AB - The National Vaccine Advisory Committee (NVAC) is a federal advisory committee that provides vaccine and immunization policy recommendations to the U.S. Department of Health and Human Services (HHS). The NVAC's diversity of professional and stakeholder perspectives enables the committee to play a role in strengthening the U.S. vaccine and immunization system, as well as inform vaccine policy. This article details the NVAC's contribution, focusing on its recent response to the 2009 H1N1 pandemic, and reveals opportunities for the NVAC to further shape this public health sector in the future. Adapted from the source document. JF - Public Health Reports AU - Shen, Angela K AU - Spinner, Jovonni R AU - Salmon, Daniel A AU - Gellin, Bruce G AD - National Vaccine Program Office, Department of Health and Human Services, 200 Independence Ave. SW, 717H, Washington, DC 20201-0004; tel. 202-690-5566; fax 202-690-4631 angela.shen@hhs.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 4 EP - 8 PB - Oxford University Press, UK VL - 126 IS - 1 SN - 0033-3549, 0033-3549 KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Diseases and disorders KW - Influenza KW - Public health KW - Vaccination and vaccines KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856399324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Strengthening+the+U.S.+Vaccine+and+Immunization+Enterprise%3A+The+Role+of+the+National+Vaccine+Advisory+Committee&rft.au=Shen%2C+Angela+K%3BSpinner%2C+Jovonni+R%3BSalmon%2C+Daniel+A%3BGellin%2C+Bruce+G&rft.aulast=Shen&rft.aufirst=Angela&rft.date=2011-01-01&rft.volume=126&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2011-03-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Vaccination and vaccines; Public health; Influenza ER - TY - JOUR T1 - Pillar strength in underground stone mines in the United States AN - 855715685; 14259435 AB - Stone mines in the Eastern and Midwestern United States make use of the room-and-pillar method of mining to extract relatively flat-laying sedimentary formations. A survey of pillar performance was carried out to identify potential modes of instability. Pillars were found to have been successful in providing support to the overburden, but a small number of individual failed pillars were observed. Failure of the pillars was observed to be related to spalling of the hard brittle rocks, shearing along pre-existing angular discontinuities or progressive extrusion of soft infill materials on bedding planes. A method of estimating the pillar strength and selecting a safety factor for design was developed based on observations of stable and failed pillars, supplemented by numerical models. The developed pillar strength equation can be used to design stable stone mine pillars provided the rock conditions are similar to those included in the study. JF - International Journal of Rock Mechanics and Mining Sciences AU - Esterhuizen, G S AU - Dolinar AU - Ellenberger, J L AD - National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA, eee5@cdc.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 42 EP - 50 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 48 IS - 1 SN - 1365-1609, 1365-1609 KW - Water Resources Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Pillar design KW - Pillar strength KW - Stone mines KW - Limestone KW - Room-and-pillar KW - Overburden KW - Mathematical models KW - Estimating KW - Safety KW - Failures KW - Surveys KW - Model Studies KW - Crystalline Rocks KW - USA KW - Strength KW - Rock Mechanics KW - Rock mechanics KW - Sedimentary structures KW - Spalling KW - Mining KW - Q2 09403:Chemicals from sea water KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855715685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences&rft.atitle=Pillar+strength+in+underground+stone+mines+in+the+United+States&rft.au=Esterhuizen%2C+G+S%3BDolinar%3BEllenberger%2C+J+L&rft.aulast=Esterhuizen&rft.aufirst=G&rft.date=2011-01-01&rft.volume=48&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2010.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Rock mechanics; Mathematical models; Sedimentary structures; Failures; Spalling; Mining; Crystalline Rocks; Rock Mechanics; Overburden; Strength; Estimating; Safety; Surveys; Model Studies; USA DO - http://dx.doi.org/10.1016/j.ijrmms.2010.06.003 ER - TY - JOUR T1 - Probabilistic modeling using bivariate normal distributions for identification of flow and displacement intervals in longwall overburden AN - 855189870; 2011-024051 AB - Gob gas ventholes (GGV) are used to control methane emissions in longwall mines by capturing it within the overlying fractured strata before it enters the work environment. In order for GGVs to effectively capture more methane and less mine air, the length of the slotted sections and their proximity to top of the coal bed should be designed based on the potential gas sources and their locations, as well as the displacements in the overburden that will create potential flow paths for the gas. In this paper, an approach to determine the conditional probabilities of depth-displacement, depth-flow percentage, depth-formation and depth-gas content of the formations was developed using bivariate normal distributions. The flow percentage, displacement and formation data as a function of distance from coal bed used in this study were obtained from a series of borehole experiments contracted by the former US Bureau of Mines as part of a research project. Each of these parameters was tested for normality and was modeled using bivariate normal distributions to determine all tail probabilities. In addition, the probability of coal bed gas content as a function of depth was determined using the same techniques. The tail probabilities at various depths were used to calculate conditional probabilities for each of the parameters. The conditional probabilities predicted for various values of the critical parameters can be used with the measurements of flow and methane percentage at gob gas ventholes to optimize their performance. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Karacan, C Ozgen AU - Goodman, Gerrit V R Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 27 EP - 41 PB - Elsevier, Oxford-New York VL - 48 IS - 1 SN - 1365-1609, 1365-1609 KW - mining KW - underground mining KW - aliphatic hydrocarbons KW - gob gas ventholes KW - coal seams KW - fractures KW - controls KW - sedimentary rocks KW - coal KW - probability KW - mines KW - experimental studies KW - bivariate analysis KW - overburden KW - methane KW - statistical analysis KW - coal mines KW - alkanes KW - research KW - preventive measures KW - depth KW - models KW - organic compounds KW - fracture zones KW - longwall mining KW - boreholes KW - hydrocarbons KW - hydraulic conductivity KW - field studies KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855189870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Probabilistic+modeling+using+bivariate+normal+distributions+for+identification+of+flow+and+displacement+intervals+in+longwall+overburden&rft.au=Karacan%2C+C+Ozgen%3BGoodman%2C+Gerrit+V+R&rft.aulast=Karacan&rft.aufirst=C&rft.date=2011-01-01&rft.volume=48&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2010.08.006 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; bivariate analysis; boreholes; coal; coal mines; coal seams; controls; depth; experimental studies; field studies; fracture zones; fractures; gob gas ventholes; hydraulic conductivity; hydrocarbons; longwall mining; methane; mines; mining; models; organic compounds; overburden; preventive measures; probability; research; sedimentary rocks; statistical analysis; underground mining DO - http://dx.doi.org/10.1016/j.ijrmms.2010.08.006 ER - TY - JOUR T1 - Food Sold in School Vending Machines Is Associated With Overall Student Dietary Intake AN - 853208819; 201106178 AB - Purpose To examine the association between food sold in school vending machines and the dietary behaviors of students. Methods The 2005-2006 U.S. Health Behavior in School-aged Children survey was administered to 6th to 10th graders and school administrators. Dietary intake in students was estimated with a brief food frequency measure. School administrators completed questions regarding food sold in vending machines. For each food intake behavior, a multilevel regression analysis modeled students (level 1) nested within schools (level 2), with the corresponding food sold in vending machines as the main predictor. Control variables included gender, grade, family affluence, and school poverty index. Analyses were conducted separately for 6th to 8th and 9th-10th grades. Results In all, 83% of the schools (152 schools; 5,930 students) had vending machines that primarily sold food of minimal nutritional values (soft drinks, chips, and sweets). In younger grades, availability of fruit and/or vegetables and chocolate and/or sweets was positively related to the corresponding food intake, with vending machine content and school poverty index providing an explanation for 70.6% of between-school variation in fruit and/or vegetable consumption and 71.7% in sweets consumption. Among the older grades, there was no significant effect of food available in vending machines on reported consumption of those food. Conclusion Vending machines are widely available in public schools in the United States. In younger grades, school vending machines were either positively or negatively related to the diets of the students, depending on what was sold in them. Schools are in a powerful position to influence the diets of children; therefore, attention to the food sold at school is necessary to try to improve their diets. [Copyright The Society for Adolescent Medicine; published by Elsevier Inc.] JF - Journal of Adolescent Health AU - Rovner, Alisha J AU - Nansel, Tonja R AU - Wang, Jing AU - Iannotti, Ronald J AD - Division of Epidemiology, Statistics and Prevention Research, Department of Health and Human Services, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 13 EP - 19 PB - Elsevier, New York NY VL - 48 IS - 1 SN - 1054-139X, 1054-139X KW - Schools Vending machines food of minimal nutritional value KW - Food consumption KW - Healthy food KW - Food KW - Vending machines KW - Fruit KW - Diet KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Food+Sold+in+School+Vending+Machines+Is+Associated+With+Overall+Student+Dietary+Intake&rft.au=Rovner%2C+Alisha+J%3BNansel%2C+Tonja+R%3BWang%2C+Jing%3BIannotti%2C+Ronald+J&rft.aulast=Rovner&rft.aufirst=Alisha&rft.date=2011-01-01&rft.volume=48&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2010.08.021 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JAHCD9 N1 - SubjectsTermNotLitGenreText - Vending machines; Food consumption; Healthy food; Food; Diet; Fruit DO - http://dx.doi.org/10.1016/j.jadohealth.2010.08.021 ER - TY - JOUR T1 - Intercountry Versus Transracial Adoption: Analysis of Adoptive Parents' Motivations and Preferences in Adoption AN - 835113170; 201101694 AB - The United States is one of the major baby-receiving countries in the world. Relatively little research has focused on why there is such a high demand for intercountry adoption. Using in-depth qualitative interviews with adoptive parents, the authors explored the reasons why Americans prefer to adopt foreign-born children instead of adopting minority children domestically. Other than infertility reasons, concerns about domestic adoption, and the uneven domestic supply and demand of 'desirable' children, the authors' findings suggested that there was a perception that American children available for adoption presented difficult problems whereas foreign children presented interesting challenges. The 'problems' inherent in children from American foster care were confounded with race differences. Studying adoption motivations will not only help us better understand the domestic adoption situation, especially why so many Black children are left behind in foster care, it may also reveal important insights into current race relations and distances between groups in the United States. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Family Issues AU - Zhang, Yuanting AU - Lee, Gary R AD - Food and Drug Administration, College Park, MD, USA Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 75 EP - 98 PB - Sage Publications, Thousand Oaks CA VL - 32 IS - 1 SN - 0192-513X, 0192-513X KW - adoption intercountry transracial motivations KW - Motivation KW - United States of America KW - Adoption KW - Foster Care KW - Adopted Children KW - Adoptive Parents KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/835113170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Issues&rft.atitle=Intercountry+Versus+Transracial+Adoption%3A+Analysis+of+Adoptive+Parents%27+Motivations+and+Preferences+in+Adoption&rft.au=Zhang%2C+Yuanting%3BLee%2C+Gary+R&rft.aulast=Zhang&rft.aufirst=Yuanting&rft.date=2011-01-01&rft.volume=32&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Issues&rft.issn=0192513X&rft_id=info:doi/10.1177%2F0192513X10375410 LA - English DB - Sociological Abstracts N1 - Date revised - 2011-01-10 N1 - Number of references - 50 N1 - Last updated - 2016-09-28 N1 - CODEN - JFISDT N1 - SubjectsTermNotLitGenreText - Adoption; Adopted Children; Foster Care; Motivation; Adoptive Parents; United States of America DO - http://dx.doi.org/10.1177/0192513X10375410 ER - TY - JOUR T1 - Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. AN - 821596339; 20929901 AB - Mutagen challenge and DNA repair assays have been used in case-control studies for nearly three decades to assess human cancer risk. The findings still engender controversy because blood was drawn after cancer diagnosis so the results may be biased, a type called 'reverse causation'. We therefore used Epstein-Barr virus-transformed lymphoblastoid cell lines established from prospectively collected peripheral blood samples to evaluate lung cancer risk in relation to three DNA repair assays: alkaline Comet assay, host cell reactivation (HCR) assay with the mutagen benzo[a]pyrene diol epoxide and the bleomycin mutagen sensitivity assay. Cases (n = 117) were diagnosed with lung cancer between 0.3 and 6 years after blood collection and controls (n = 117) were frequency matched on calendar year and age at blood collection, gender and smoking history; all races were included. Case and control status was unknown to laboratory investigators. In unconditional logistic regression analyses, statistically significantly increased lung cancer odds ratios (OR(adjusted)) were observed for bleomycin mutagen sensitivity as quartiles of chromatid breaks/cell [relative to the lowest quartile, OR = 1.2, 95% confidence interval (CI): 0.5-2.5; OR = 1.4, 95% CI: 0.7-3.1; OR = 2.1, 95% CI: 1.0-4.4, respectively, P(trend) = 0.04]. The magnitude of the association between the bleomycin assay and lung cancer risk was modest compared with those reported in previous lung cancer studies but was strengthened when we included only incident cases diagnosed more than a year after blood collection (P(trend) = 0.02), supporting the notion the assay may be a measure of cancer susceptibility. The Comet and HCR assays were unrelated to lung cancer risk. JF - Carcinogenesis AU - Sigurdson, Alice J AU - Jones, Irene M AU - Wei, Qingyi AU - Wu, Xifeng AU - Spitz, Margaret R AU - Stram, Douglas A AU - Gross, Myron D AU - Huang, Wen-Yi AU - Wang, Li-E AU - Gu, Jian AU - Thomas, Cynthia B AU - Reding, Douglas J AU - Hayes, Richard B AU - Caporaso, Neil E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. sigurdsa@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 69 EP - 73 VL - 32 IS - 1 KW - Antibiotics, Antineoplastic KW - 0 KW - Biomarkers, Tumor KW - Bleomycin KW - 11056-06-7 KW - Index Medicus KW - Comet Assay KW - Randomized Controlled Trials as Topic KW - Mutagenicity Tests KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Cell Line, Tumor KW - Male KW - Female KW - DNA Repair -- genetics KW - Biomarkers, Tumor -- genetics KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821596339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Prospective+analysis+of+DNA+damage+and+repair+markers+of+lung+cancer+risk+from+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+%28PLCO%29+Cancer+Screening+Trial.&rft.au=Sigurdson%2C+Alice+J%3BJones%2C+Irene+M%3BWei%2C+Qingyi%3BWu%2C+Xifeng%3BSpitz%2C+Margaret+R%3BStram%2C+Douglas+A%3BGross%2C+Myron+D%3BHuang%2C+Wen-Yi%3BWang%2C+Li-E%3BGu%2C+Jian%3BThomas%2C+Cynthia+B%3BReding%2C+Douglas+J%3BHayes%2C+Richard+B%3BCaporaso%2C+Neil+E&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2011-01-01&rft.volume=32&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgq204 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-27 N1 - Date created - 2010-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2001 May 26;166(2):155-63 [11311488] Crit Rev Oncol Hematol. 2001 Feb;37(2):87-96 [11166582] Environ Mol Mutagen. 2002;40(2):79-84 [12203399] Mutat Res. 2002 Nov 30;509(1-2):165-74 [12427537] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1496-8 [12433734] Mutagenesis. 2002 Nov;17(6):489-93 [12435846] Mutat Res. 2003 May 15;526(1-2):93-125 [12714187] Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):689-98 [12917198] J Natl Cancer Inst. 2003 Sep 3;95(17):1263-5 [12953074] Mutagenesis. 2004 Jul;19(4):285-90 [15215327] Hereditas. 1983;98(1):1-9 [6303985] Proc Natl Acad Sci U S A. 1983 Sep;80(18):5612-6 [6577447] Proc Natl Acad Sci U S A. 1985 Aug;82(16):5400-3 [3860870] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] Int J Cancer. 1989 Mar 15;43(3):403-9 [2466800] In Vitro Cell Dev Biol. 1990 Jan;26(1):80-4 [1689712] Cancer Res. 1991 Nov 1;51(21):5786-93 [1933849] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):191-7 [8833619] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):199-204 [8833620] Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):567-77 [10385149] Mutat Res. 2005 Oct 3;586(2):173-88 [16099702] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1935-40 [17035402] Cancer Res. 2007 Apr 15;67(8):3493-5 [17440053] Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):990-4 [18398043] Cancer Lett. 2008 Jul 18;266(1):60-72 [18374480] J Clin Oncol. 2008 Jul 20;26(21):3560-6 [18640936] Int J Cancer. 2009 Mar 1;124(5):999-1007 [19065660] Mutat Res. 2010 Feb 3;684(1-2):98-105 [20035771] J Natl Cancer Inst. 2000 Jun 7;92(11):874-97 [10841823] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] Mutagenesis. 2001 Jan;16(1):25-30 [11139596] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] Mutagenesis. 2002 May;17(3):211-4 [11971991] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgq204 ER - TY - JOUR T1 - Virulence characterization of Shiga-toxigenic Escherichia coli isolates from wholesale produce. AN - 821193223; 21057025 AB - The 13 Shiga-toxigenic Escherichia coli (STEC) strains isolated from wholesale spinach and lettuce consisted mostly of serotypes that have not been implicated in illness. Among these strains, however, were two O113:H21 that carried virulence genes common to this pathogenic serotype (stx(2), ehxA, saa, and subAB), suggesting that their presence in ready-to-eat produce may be of health concern. JF - Applied and environmental microbiology AU - Feng, Peter C H AU - Councell, Terry AU - Keys, Christine AU - Monday, Steven R AD - Division of Microbiology, US Food and Drug Administration, College Park, MD 20740, USA. peter.feng@fda.hhs.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 343 EP - 345 VL - 77 IS - 1 KW - Escherichia coli Proteins KW - 0 KW - Virulence Factors KW - Index Medicus KW - Escherichia coli Proteins -- genetics KW - Lettuce -- microbiology KW - Shiga-Toxigenic Escherichia coli -- isolation & purification KW - Spinacia oleracea -- microbiology KW - Virulence Factors -- genetics KW - Shiga-Toxigenic Escherichia coli -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821193223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Virulence+characterization+of+Shiga-toxigenic+Escherichia+coli+isolates+from+wholesale+produce.&rft.au=Feng%2C+Peter+C+H%3BCouncell%2C+Terry%3BKeys%2C+Christine%3BMonday%2C+Steven+R&rft.aulast=Feng&rft.aufirst=Peter+C&rft.date=2011-01-01&rft.volume=77&rft.issue=1&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.01872-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-15 N1 - Date created - 2010-12-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Probes. 2000 Dec;14(6):333-7 [11090262] Eur J Epidemiol. 2000;16(8):757-62 [11142505] Infect Immun. 2001 Nov;69(11):6999-7009 [11598075] J Clin Microbiol. 2002 Jan;40(1):271-4 [11773130] J Infect Dis. 1985 May;151(5):775-82 [3886804] Infect Immun. 1994 Aug;62(8):3494-505 [7518809] J Clin Microbiol. 1999 Oct;37(10):3357-61 [10488206] J Clin Microbiol. 1999 Oct;37(10):3362-5 [10488207] Vet Microbiol. 2005 Jan 5;105(1):29-36 [15607081] Infect Immun. 2005 May;73(5):3063-71 [15845514] Res Microbiol. 2006 Apr;157(3):263-6 [16171978] Appl Environ Microbiol. 2006 Apr;72(4):3062-5 [16598020] J Bacteriol. 2007 Jan;189(2):342-50 [17098897] J Anim Sci. 2007 Mar;85(13 Suppl):E63-72 [17060419] Mol Cell Probes. 2007 Aug;21(4):308-11 [17383154] Emerg Infect Dis. 2009 Mar;15(3):372-80 [19239748] Infect Immun. 2009 Aug;77(8):3234-43 [19487483] J Clin Microbiol. 2010 Mar;48(3):988-90 [20089761] J Med Microbiol. 2010 Jun;59(Pt 6):634-40 [20223897] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.01872-10 ER - TY - JOUR T1 - Malformation syndromes caused by disorders of cholesterol synthesis. AN - 821191218; 20929975 AB - Cholesterol homeostasis is critical for normal growth and development. In addition to being a major membrane lipid, cholesterol has multiple biological functions. These roles include being a precursor molecule for the synthesis of steroid hormones, neuroactive steroids, oxysterols, and bile acids. Cholesterol is also essential for the proper maturation and signaling of hedgehog proteins, and thus cholesterol is critical for embryonic development. After birth, most tissues can obtain cholesterol from either endogenous synthesis or exogenous dietary sources, but prior to birth, the human fetal tissues are dependent on endogenous synthesis. Due to the blood-brain barrier, brain tissue cannot utilize dietary or peripherally produced cholesterol. Generally, inborn errors of cholesterol synthesis lead to both a deficiency of cholesterol and increased levels of potentially bioactive or toxic precursor sterols. Over the past couple of decades, a number of human malformation syndromes have been shown to be due to inborn errors of cholesterol synthesis. Herein, we will review clinical and basic science aspects of Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis, HEM dysplasia, X-linked dominant chondrodysplasia punctata, Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects Syndrome, sterol-C-4 methyloxidase-like deficiency, and Antley-Bixler syndrome. JF - Journal of lipid research AU - Porter, Forbes D AU - Herman, Gail E AD - Program in Developmental Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. fdporter@mail.nih.gov Y1 - 2011/01// PY - 2011 DA - January 2011 SP - 6 EP - 34 VL - 52 IS - 1 KW - Cholesterol KW - 97C5T2UQ7J KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - Index Medicus KW - Smith-Lemli-Opitz Syndrome -- metabolism KW - Abnormalities, Multiple -- genetics KW - Animals KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Humans KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Abnormalities, Multiple -- etiology KW - Oxidoreductases Acting on CH-CH Group Donors -- metabolism KW - Chondrodysplasia Punctata -- genetics KW - Chondrodysplasia Punctata -- etiology KW - Smith-Lemli-Opitz Syndrome -- etiology KW - Syndrome KW - Abnormalities, Multiple -- metabolism KW - Oxidoreductases Acting on CH-CH Group Donors -- deficiency KW - Steroid Metabolism, Inborn Errors KW - Chondrodysplasia Punctata -- metabolism KW - Cholesterol -- biosynthesis KW - Lipid Metabolism, Inborn Errors -- etiology KW - Lipid Metabolism, Inborn Errors -- complications KW - Congenital Abnormalities -- etiology KW - Lipid Metabolism, Inborn Errors -- genetics KW - Lipid Metabolism, Inborn Errors -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821191218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+lipid+research&rft.atitle=Malformation+syndromes+caused+by+disorders+of+cholesterol+synthesis.&rft.au=Porter%2C+Forbes+D%3BHerman%2C+Gail+E&rft.aulast=Porter&rft.aufirst=Forbes&rft.date=2011-01-01&rft.volume=52&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+lipid+research&rft.issn=1539-7262&rft_id=info:doi/10.1194%2Fjlr.R009548 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-06-21 N1 - Date created - 2010-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2191-7 [17761942] Am J Med Genet A. 2007 Oct 15;143A(20):2371-81 [17853487] Biochem Biophys Res Commun. 2007 Nov 23;363(3):800-5 [17904101] Am J Med Genet A. 2008 Jan 15;146A(2):208-11 [18076100] Mol Cell Biol. 2008 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- 2017-01-18 DO - http://dx.doi.org/10.1194/jlr.R009548 ER - TY - JOUR T1 - Considerations when submitting nanotherapeutics to FDA/CDER for regulatory review. AN - 815553142; 21116951 AB - The Food and Drug Administration (FDA) does not, as yet, have specific guidances for products containing nanoscale materials. As announced in the report issued by the FDA Nanotechnology Task Force (July 2007), however, there are recommendations to various centers within the FDA to develop guidances for industry. Regardless of the lack of explicit FDA guidances, there are therapeutics currently on the market containing nanoscale materials, and additional novel nanomaterial-containing therapeutics are being developed with the hopes of being submitted for regulatory review and approval. While, for the most part, these novel nanomaterial-containing products are being evaluated using the same regulatory requirements as products that do not contain nanomaterials, it is increasingly evident that at least in the area of characterization of nanomaterials used in drug products, there may be areas where special focus is needed. Specific areas include the validity of applying small molecule principles and methodologies to nanomaterial-containing products, the effects the nanomaterial will impart to the rest of the formulation (or vice versa), and how the physicochemical properties may be impacted by biological settings. Similarly, for safety evaluation, biodistribution studies will be at the core of any evaluation of products containing nanomaterials. These biodistribution studies will, in effect, be indicative of where the nanoparticles are traveling and possibly accumulating, therefore subjecting those sites to increased likelihood of toxicological effects. This chapter focuses on questions and considerations that may arise for sponsors during product characterization, as well as considerations for the appropriate design and conduct of in vivo toxicology studies. This chapter will also review how current FDA guidances apply to nanotherapeutics.This chapter reflects the current thinking and experience of the authors. However, this is not a policy document and should not be used in lieu of regulations, published FDA guidances, or direct discussions with the agency. JF - Methods in molecular biology (Clifton, N.J.) AU - Tyner, Katherine AU - Sadrieh, Nakissa AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2011 PY - 2011 DA - 2011 SP - 17 EP - 31 VL - 697 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Investigational New Drug Application KW - Nanoparticles -- adverse effects KW - Guidelines as Topic KW - Nanoparticles -- toxicity KW - Pharmacokinetics KW - Nanoparticles -- chemistry KW - Pharmaceutical Preparations -- administration & dosage KW - Drug Approval -- methods KW - Nanostructures -- chemistry KW - Nanostructures -- adverse effects KW - Pharmaceutical Preparations -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815553142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Considerations+when+submitting+nanotherapeutics+to+FDA%2FCDER+for+regulatory+review.&rft.au=Tyner%2C+Katherine%3BSadrieh%2C+Nakissa&rft.aulast=Tyner&rft.aufirst=Katherine&rft.date=2011-01-01&rft.volume=697&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-198-1_3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-05-13 N1 - Date created - 2010-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-198-1_3 ER - TY - JOUR T1 - A Computer-Controlled Whole-Body Inhalation Exposure System for the Oil Dispersant COREXIT EC9500A AN - 1777171357; 15876008 AB - An automated whole-body inhalation exposure system capable of exposing 12 individually housed rats was designed to examine the potential adverse health effects of the oil dispersant COREXIT EC9500A, used extensively during the Deepwater Horizon oil spill. A computer-controlled syringe pump injected the COREXIT EC9500A into an atomizer where droplets and vapor were formed and mixed with diluent air. The aerosolized COREXIT EC9500A was passed into a customized exposure chamber where a calibrated light-scattering instrument estimated the real-time particle mass concentration of the aerosol in the chamber. Software feedback loops controlled the chamber aerosol concentration and pressure throughout each exposure. The particle size distribution of the dispersant aerosol was measured and shown to have a count median aerodynamic diameter of 285 nm with a geometric standard deviation of 1.7. The total chamber concentration (particulate + vapor) was determined using a modification of the acidified methylene blue spectrophotometric assay for anionic surfactants. Tests were conducted to show the effectiveness of closed loop control of chamber concentration and to verify chamber concentration homogeneity. Five automated 5-h animal exposures were performed that produced controlled and consistent COREXIT EC9500A concentrations (27.1 ? 2.9 mg/m3, mean ? SD). JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Goldsmith, William Travis AU - McKinney, Walter AU - Jackson, Mark AU - Law, Brandon AU - Bledsoe, Toni AU - Siegel, Paul AU - Cumpston, Jared AU - Frazer, David AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1368 EP - 1380 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 21 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Inhalation KW - Homogeneity KW - Aerosols KW - Droplets KW - Chambers KW - Health KW - Dispersants KW - Automated UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777171357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=A+Computer-Controlled+Whole-Body+Inhalation+Exposure+System+for+the+Oil+Dispersant+COREXIT+EC9500A&rft.au=Goldsmith%2C+William+Travis%3BMcKinney%2C+Walter%3BJackson%2C+Mark%3BLaw%2C+Brandon%3BBledsoe%2C+Toni%3BSiegel%2C+Paul%3BCumpston%2C+Jared%3BFrazer%2C+David&rft.aulast=Goldsmith&rft.aufirst=William&rft.date=2011-01-01&rft.volume=74&rft.issue=21&rft.spage=1368&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.606793 L2 - http://www.tandfonline.com/doi/abs/10.1080/15287394.2011.606793 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287394.2011.606793 ER - TY - JOUR T1 - Acute Effects of COREXIT EC9500A on Cardiovascular Functions in Rats AN - 1777171053; 15876010 AB - These studies characterized cardiovascular responses after an acute inhalation exposure to COREXIT EC9500A, the oil dispersant used in the Deepwater Horizon oil spill. Male Sprague-Dawley rats underwent a single 5-h inhalation exposure to COREXIT EC9500A (average exposure level 27.12 mg/m3) or air. On d 1 and 7 following the exposure, rats were implanted with indwelling catheters and changes in heart rate and blood pressure were assessed in response to increasing levels of adrenoreceptor agonists. A separate group of rats was euthanized at the same time points, ventral tail arteries were dissected, and vascular tone along with dose-dependent responses to vasoconstricting and dilating factors were assessed in vitro. Agonist-induced dose-dependent increases in heart rate and blood pressure were greater in COREXIT EC9500A-exposed than in air-exposed rats at 1 d but not 7 d after the exposure. COREXIT EC9500A exposure also induced a rise in basal tone and reduced responsiveness of tail arteries to acetylcholine-induced vasodilation at 1 d but not 7 d following the exposure. These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Krajnak, Kristine AU - Kan, Hong AU - Waugh, Stacey AU - Miller, G Roger AU - Johnson, Claud AU - Roberts, Jenny R AU - Goldsmith, William Travis AU - Jackson, Mark AU - McKinney, Walter AU - Frazer, David AU - Kashon, Michael L AU - Castranova, Vincent AD - Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1397 EP - 1404 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 21 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Rats KW - Inhalation KW - Males KW - Arteries KW - Heart rate KW - Catheters KW - Toxicology KW - Blood pressure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777171053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Acute+Effects+of+COREXIT+EC9500A+on+Cardiovascular+Functions+in+Rats&rft.au=Krajnak%2C+Kristine%3BKan%2C+Hong%3BWaugh%2C+Stacey%3BMiller%2C+G+Roger%3BJohnson%2C+Claud%3BRoberts%2C+Jenny+R%3BGoldsmith%2C+William+Travis%3BJackson%2C+Mark%3BMcKinney%2C+Walter%3BFrazer%2C+David%3BKashon%2C+Michael+L%3BCastranova%2C+Vincent&rft.aulast=Krajnak&rft.aufirst=Kristine&rft.date=2011-01-01&rft.volume=74&rft.issue=21&rft.spage=1397&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.606795 L2 - http://www.tandfonline.com/doi/abs/10.1080/15287394.2011.606795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287394.2011.606795 ER - TY - JOUR T1 - Impact of Repeated Nicotine and Alcohol Coexposure on in Vitro and in Vivo Chlorpyrifos Dosimetry and Cholinesterase Inhibition AN - 1777169201; 15876005 AB - Chlorpyrifos (CPF) is an organophosphorus insecticide, and neurotoxicity results from inhibition of acetylcholinesterase (AChE) by its metabolite, chlorpyrifos-oxon. Routine consumption of alcohol and tobacco modifies metabolic and physiological processes impacting the metabolism and pharmacokinetics of other xenobiotics, including pesticides. This study evaluated the influence of repeated ethanol and nicotine coexposure on in vivo CPF dosimetry and cholinesterase (ChE) response (ChE- includes AChE and/or butyrylcholinesterase (BuChE)). Hepatic microsomes were prepared from groups of naive, ethanol-only (1 g/kg/d, 7 d, po), and ethanol + nicotine (1 mg/kg/d 7 d, sc)-treated rats, and the in vitro metabolism of CPF was evaluated. For in vivo studies, rats were treated with saline or ethanol (1 g/kg/d, po) + nicotine (1 mg/kg/d, sc) in addition to CPF (1 or 5 mg/kg/d, po) for 7 d. The major CPF metabolite, 3,5,6-trichloro-2-pyridinol (TCPy), in blood and urine and the plasma ChE and brain acetylcholinesterase (AChE) activities were measured in rats. There were differences in pharmacokinetics, with higher TCPy peak concentrations and increased blood TCPy AUC in ethanol + nicotine groups compared to CPF only (approximately 1.8- and 3.8-fold at 1 and 5 mg CPF doses, respectively). Brain AChE activities after ethanol + nicotine treatments showed significantly less inhibition following repeated 5 mg CPF/kg dosing compared to CPF only (96 ? 13 and 66 ? 7% of naive at 4 h post last CPF dosing, respectively). Although brain AChE activity was minimal inhibited for the 1-mg CPF/kg/d groups, the ethanol + nicotine pretreatment resulted in a similar trend (i.e., slightly less inhibition). No marked differences were observed in plasma ChE activities due to the alcohol + nicotine treatments. In vitro, CPF metabolism was not markedly affected by repeated ethanol or both ethanol + nicotine exposures. Compared with a previous study of nicotine and CPF exposure, there were no apparent additional exacerbating effects due to ethanol coexposure. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Lee, S AU - Poet, T S AU - Smith, J N AU - Hjerpe, A L AU - Gunawan, R AU - Timchalk, C AD - Food and Drug Administration, Atlanta, Georgia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 1334 EP - 1350 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 20 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Biocompatibility KW - In vitro testing KW - Alcohols KW - Nicotine KW - Surgical implants KW - Ethyl alcohol KW - Inhibition KW - Ethanol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777169201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Impact+of+Repeated+Nicotine+and+Alcohol+Coexposure+on+in+Vitro+and+in+Vivo+Chlorpyrifos+Dosimetry+and+Cholinesterase+Inhibition&rft.au=Lee%2C+S%3BPoet%2C+T+S%3BSmith%2C+J+N%3BHjerpe%2C+A+L%3BGunawan%2C+R%3BTimchalk%2C+C&rft.aulast=Lee&rft.aufirst=S&rft.date=2011-01-01&rft.volume=74&rft.issue=20&rft.spage=1334&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.567958 L2 - http://www.tandfonline.com/doi/abs/10.1080/15287394.2011.567958 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287394.2011.567958 ER - TY - JOUR T1 - A comparison between IECM and IEM Lagrangian models AN - 1777129891; 14430636 AB - A three-dimensional Lagrangian stochastic model to evaluate pollutant dispersion in terms of both mean and fluctuating concentration fields has been developed. The mean concentration field is predicted by using a macromixing model, while the micromixing scheme IECM (Interaction by Exchange with the Conditional Mean) is adopted to determine the moments of concentration. The results agree with experimental data and with other numerical studies found in literature. The performance of a second micromixing scheme, namely, the IEM (Interaction by Exchange with the Mean), is tested. Some inaccuracies of the IEM model are evaluated by comparison against measurements and IECM results. JF - International Journal of Environment and Pollution AU - Amicarelli, Andrea AU - Leuzzi, Giovanni AU - Monti, Paolo AU - Thomson, David J AD - DIPIA, ISPESL - National Institute for Occupational Safety and Health, Via Fontana Candida 1, 00040 Monteporzio Catone, RM, Italy. Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 324 EP - 331 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB UK VL - 44 IS - 1-2-3-4 SN - 0957-4352, 0957-4352 KW - Materials Business File (MB); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - ENERGY AND ENVIRONMENT KW - Environment and Sustainable Development KW - Dispersions KW - Mathematical models KW - Pollutants KW - Fluctuation KW - Pollution abatement KW - Micromixing KW - Stochasticity KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777129891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Environment+and+Pollution&rft.atitle=A+comparison+between+IECM+and+IEM+Lagrangian+models&rft.au=Amicarelli%2C+Andrea%3BLeuzzi%2C+Giovanni%3BMonti%2C+Paolo%3BThomson%2C+David+J&rft.aulast=Amicarelli&rft.aufirst=Andrea&rft.date=2011-01-01&rft.volume=44&rft.issue=1-2-3-4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Environment+and+Pollution&rft.issn=09574352&rft_id=info:doi/10.1504%2FIJEP.2011.038433 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-06-30 DO - http://dx.doi.org/10.1504/IJEP.2011.038433 ER - TY - JOUR T1 - Toxicological Evaluation of Lung Responses After Intratracheal Exposure to Non-Dispersed Titanium Dioxide Nanorods AN - 1777124063; 15154190 AB - Fine- and coarse-sized titanium dioxide (TiO2) particles are considered to be relatively inert when inhaled. The goal of this study was to assess potential lung toxicity associated with well-characterized, non-dispersed rutile TiO2 nanorods (10 t 40 nm). In vitro bioreactivity of TiO2 nanorods was determined by electron spin resonance (ESR) to measure free radical production. To assess pulmonary effects in vivo, Sprague-Dawley rats were intratracheally instilled with saline, silica, or TiO2 nanorods (10 Delta *mg, 100 Delta *mg, or 1 mg/rat). On d 1, 3, and 6 posttreatment, left lungs were preserved for microscopy and histopathology, and lung lavage was performed on right lungs. Additional rats were treated with saline or TiO2 nanorods (100 Delta *mg or 1 mg/rat) on d 0, intratracheally inoculated with 5 t 105 Listeria monocytogenes on d 3, and bacterial clearance was assessed. ESR showed a significant concentration-dependent generation of hydroxyl radicals by TiO2 nanorods in the presence and absence of macrophages; however, the hydroxyl radical signals from TiO2 samples were low compared to silica. Rats exposed to 1 mg of TiO2 nanorods had significantly elevated levels of lung injury, inflammation, and lavage fluid monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-2 on d 1 and 3 that subsided by d 6, unlike the silica response that persisted. Immune cytokine secretion in the lung and bacterial clearance were not affected by preexposure to TiO2 nanorods. To summarize, non-dispersed TiO2 nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Roberts, Jenny R AU - Chapman, Rebecca S AU - Tirumala, Vijay R AU - Karim, Alamgir AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Stefaniak, Aleksandr B AU - Leonard, Stephen S AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 7-9 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Rats KW - Macrophages KW - Bacteria KW - Biocompatibility KW - Titanium dioxide KW - Nanorods KW - Lungs KW - Silicon dioxide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777124063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Toxicological+Evaluation+of+Lung+Responses+After+Intratracheal+Exposure+to+Non-Dispersed+Titanium+Dioxide+Nanorods&rft.au=Roberts%2C+Jenny+R%3BChapman%2C+Rebecca+S%3BTirumala%2C+Vijay+R%3BKarim%2C+Alamgir%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BStefaniak%2C+Aleksandr+B%3BLeonard%2C+Stephen+S%3BAntonini%2C+James+M&rft.aulast=Roberts&rft.aufirst=Jenny&rft.date=2011-01-01&rft.volume=74&rft.issue=7-9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.567954 L2 - http://www.informaworld.com/smpp/content~db=all~content=a937142880~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287394.2011.567954 ER - TY - JOUR T1 - Determining When Enhanced Pause (Penh) is Sensitive to Changes in Specific Airway Resistance AN - 1777118539; 15154152 AB - Penh is a dimensionless index normally used to evaluate changes in the shape of the airflow pattern entering and leaving a whole-body flow plethysmograph as an animal breathes. The index is sensitive to changes in the distribution of area under the waveform during exhalation and increases in a nonlinear fashion as the normalized area increases near the beginning of the curve. Enhanced pause (Penh) has been used to evaluate changes in pulmonary function and as a method to evaluate airway reactivity. However, the use of Penh to assess pulmonary function has been challenged (Bates et al., 2004; Lundblad et al., 2002; Mitzner et al., 2003; Mitzner & Tankersley, 1998; Petak et al., 2001; Sly et al., 2005). The objective of this study was to show how Penh of the thorax and plethysmograph flow patterns are related. That relationship is used to describe the conditions under which whole-body plethysmograph Penh measurements can be used to detect changes in sRaw. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Frazer, David G AU - Reynolds, Jeffrey S AU - Jackson, Mark C AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 74 IS - 7-9 SN - 1528-7394, 1528-7394 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Waveforms KW - Pulmonary functions KW - Exhalation KW - Airways KW - Thorax KW - Nonlinearity KW - Commercial planes KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777118539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Determining+When+Enhanced+Pause+%28Penh%29+is+Sensitive+to+Changes+in+Specific+Airway+Resistance&rft.au=Frazer%2C+David+G%3BReynolds%2C+Jeffrey+S%3BJackson%2C+Mark+C&rft.aulast=Frazer&rft.aufirst=David&rft.date=2011-01-01&rft.volume=74&rft.issue=7-9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2010.514235 L2 - http://www.informaworld.com/smpp/content~db=all~content=a932366246~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1080/15287394.2010.514235 ER - TY - JOUR T1 - Urinary pH, cigarette smoking and bladder cancer risk AN - 1660409789; 18514226 AB - Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the association between urine pH and bladder cancer risk, alone and in combination with cigarette smoking. In total, 712 incident urothelial cell carcinoma cases and 611 hospital controls directly measured their urine pH with dipsticks twice a day (first void in the morning and early in the evening) during four consecutive days 2 weeks after hospital discharge. We found that a consistently acidic urine pH less than or equal to 6.0 was associated with an increased risk of bladder cancer [odds ratio (OR) = 1.5, 95% confidence interval (CI): 1.2-1.9] compared with all other subjects. Furthermore, risk estimates for smoking intensity and risk of bladder cancer among current smokers tended to be higher for those with a consistently acidic urine (OR = 8.8, 11.5 and 23.8) compared with those without (OR = 4.3, 7.7 and 5.8, respectively, for 1-19, 20-29 and 30+ cigarettes per day; P sub(interaction) for 30+ cigarettes per day = 0.024). These results suggest that urine pH, which is determined primarily by diet and body surface area, may be an important modifier of smoking and risk of bladder cancer. JF - Carcinogenesis AU - Alguacil, Juan AU - Kogevinas, Manolis AU - Silverman, Debra T AU - Malats, Nuria AU - Real, Francisco X AU - Garcia-Closas, Montserrat AU - Tardon, Adonina AU - Rivas, Manuel AU - Tora, Montserrat AU - Garcia-Closas, Reina AU - Serra, Consol AU - Carrato, Alfredo AU - Pfeiffer, Ruth M AU - Fortuny, Joan AU - Samanic, Claudine AU - Rothman, Nathaniel AD - 1 Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA, alguacil@dbasp.uhu.es Y1 - 2011 PY - 2011 DA - 2011 SP - 843 EP - 847 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 32 IS - 6 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - DNA adducts KW - Etiology KW - Urinary bladder KW - Surface area KW - urothelium KW - urothelial carcinoma KW - Urine KW - Carcinogenesis KW - Cigarette smoking KW - Metabolic activation KW - pH effects KW - Hospitals KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660409789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Urinary+pH%2C+cigarette+smoking+and+bladder+cancer+risk&rft.au=Alguacil%2C+Juan%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra+T%3BMalats%2C+Nuria%3BReal%2C+Francisco+X%3BGarcia-Closas%2C+Montserrat%3BTardon%2C+Adonina%3BRivas%2C+Manuel%3BTora%2C+Montserrat%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BPfeiffer%2C+Ruth+M%3BFortuny%2C+Joan%3BSamanic%2C+Claudine%3BRothman%2C+Nathaniel&rft.aulast=Alguacil&rft.aufirst=Juan&rft.date=2011-01-01&rft.volume=32&rft.issue=6&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Diets; DNA adducts; Etiology; Urinary bladder; Surface area; urothelium; urothelial carcinoma; Urine; Cigarette smoking; Carcinogenesis; Metabolic activation; pH effects; Hospitals DO - http://dx.doi.org/10.1093/carcin/bgr048 ER - TY - BOOK T1 - Combat and operational behavioral health T2 - Textbooks of military medicine AN - 1435842650; 86391 JF - Falls Church, Virginia: Office of the Surgeon General, United States Army, 2011. lxxi, 780 pp. AU - Ritchie, Elspeth Cameron PY - 2011 SP - 2 EP - lxxi, 780 PB - Office of the Surgeon General, United States Army SN - 9780160887567 KW - Family Members KW - Injuries KW - Military Personnel KW - Military Psychiatry KW - Prevention KW - Psychiatric Disorders KW - Survivors KW - Veterans KW - War UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1435842650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PILOTS%3A+Published+International+Literature+On+Traumatic+Stress&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Ritchie%2C+Elspeth+Cameron&rft.aulast=Ritchie&rft.aufirst=Elspeth&rft.date=2011-01-01&rft.volume=&rft.issue=&rft.spage=lxxi&rft.isbn=9780160887567&rft.btitle=Combat+and+operational+behavioral+health&rft.title=Combat+and+operational+behavioral+health&rft.issn=&rft_id=info:doi/ LA - English DB - PILOTS: Published International Literature On Traumatic Stress N1 - Date revised - 2016-09-15 N1 - Last updated - 2016-09-15 ER - TY - JOUR T1 - RegStatGel: Proteomic software for identifying differentially expressed proteins based on 2D gel images AN - 1367481475; 16380549 AB - Image analysis of two-dimensional gel electrophoresis is a key step in proteomic workflow for identifying proteins that change under different experimental conditions. Since there are usually large amount of proteins and variations shown in the gel images, the use of software for analysis of 2D gel images is inevitable. We developed open-source software with graphical user interface for differential analysis of 2D gel images. The user-friendly software, RegStatGel, contains fully automated as well as interactive procedures. It was developed and has been tested under Matlab 7.01. JF - Bioinformation AU - Li, F AU - Seillier-Moiseiwitsch, F AD - Department of Mathematics and Statistics, University of Maryland, Baltimore County, Baltimore, Maryland, USA, feng.li@fda.hhs.gov A2 - Kangueane, P (ed) Y1 - 2011 PY - 2011 DA - 2011 SP - 389 EP - 390 VL - 6 IS - 10 SN - 0973-2063, 0973-2063 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Image processing KW - proteomics KW - Gel electrophoresis KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367481475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformation&rft.atitle=RegStatGel%3A+Proteomic+software+for+identifying+differentially+expressed+proteins+based+on+2D+gel+images&rft.au=Li%2C+F%3BSeillier-Moiseiwitsch%2C+F&rft.aulast=Li&rft.aufirst=F&rft.date=2011-01-01&rft.volume=6&rft.issue=10&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Bioinformation&rft.issn=09732063&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Image processing; proteomics; Gel electrophoresis ER - TY - GEN T1 - Training Frontline Staff. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322248732; ED540219 AB - This four-part workbook will help program leaders teach education specialists the principles, processes, and skills necessary to deliver effective Supported Education services. The workbook includes the following: (1) Basic elements and practice principles of Supported Education; (2) Knowledge and skills to help consumers make informed choices about returning to school; (3) Skills and supports to help enrollment activities; and (4) Follow-along activities to support educational goals. It also includes exercises and activities that education specialists can complete to master necessary skills. Use this workbook to train your Supported Education staff. AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 84 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Adult Education KW - Postsecondary Education KW - Counseling Services KW - Meetings KW - Referral KW - Decision Making KW - Job Training KW - Eligibility KW - Student Financial Aid KW - Mental Disorders KW - School Policy KW - Enrollment KW - Goal Orientation KW - Academic Accommodations (Disabilities) KW - Inclusion KW - Specialists KW - Student Personnel Services KW - Admission (School) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322248732?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - Using Multimedia to Introduce Your Promising Practice. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322248697; ED540221 AB - Supported Education is a promising practice that helps people with mental illnesses who are interested in education and training return to school. Current research shows that Supported Education has demonstrated results. While more research is needed, Supported Education services show promise of becoming an evidence-based practice. Education specialists can help: (1) Choose an education program; (2) Complete enrollment and financial aid forms; and (3) Secure supports to help consumers stay in school. "Using Multimedia to Introduce Your Promising Practice" is a collection of educational tools to help in introducing Supported Education to a variety of stakeholder groups, including the following: (1) Mental health authorities; (2) Community members; (3) Consumers; (4) Families and other supporters; and (5) Agency-wide staff. Anyone who is trained in the Supported Education model (including program leaders, education specialists, and advisory group members) should be able to use these tools during inservice training meetings or for community presentations to educate stakeholder groups. Appended are: (1) Sample Brochure; and (2) PowerPoint Presentation. AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 50 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Adult Education KW - Postsecondary Education KW - Mental Disorders KW - Visual Aids KW - Inclusion KW - Publications KW - Multimedia Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322248697?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - Evaluating Your Program. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322248084; ED540222 AB - Key stakeholders who implement Supported Education may find themselves asking two questions: (1) Has Supported Education been implemented as planned?; and (2) Has Supported Education resulted in the expected outcomes? Asking these two questions and using the answers to help improve Supported Education are critical for ensuring the success of one's program. "Evaluating Your Program" shows quality assurance team members how to evaluate the effectiveness of Supported Education. It includes the following: (1) A Readiness Assessment; (2) The Supported Education Fidelity Scale; and (3) Outcome measures that are specific to Supported Education. Readers will also find instructions for conducting assessments and tips on how to use the data to improve one's program. Appended are: (1) Cover Sheet--Supported Education Fidelity Scale; (2) Supported Education Fidelity Scale and Scoresheet; (3) Supported Education Fidelity Scale Protocol; (4) Outcomes Report Form; (5) Instructions for the Outcomes Report Form; and (6) Assessor Training and Work Performance Checklist. (Contains 2 figures and 2 tables.) AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 104 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Adult Education KW - Program Effectiveness KW - Stakeholders KW - Outcome Measures KW - Measures (Individuals) KW - Evaluation Needs KW - Research Methodology KW - Readiness KW - Improvement Programs KW - Mental Health Programs KW - Quality Assurance KW - Evaluation Methods KW - Fidelity KW - Program Improvement KW - Educational Principles KW - Evaluation Research KW - Best Practices KW - Evaluation Criteria KW - Disabilities KW - Program Evaluation KW - Evidence KW - Quality Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322248084?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - The Evidence. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322248077; ED540220 AB - Supported Employment is an evidence-based practice that helps people with mental illness find and keep meaningful jobs in the community. Given these outcomes the challenge for Supported Employment programs is to rethink the emphasis on immediate work for everyone and help consumers utilize appropriate education and training opportunities available in their communities so they can, over time, qualify for skilled jobs and professional careers (Baron & Salzer, 2000; Bond et al., 2001). This paper introduces all stakeholders to the research literature and other resources on Supported Education. This booklet includes the following resources: (1) Review of the research literature; (2) Selected bibliography for further reading; (3) References for the citations presented throughout the KIT; and (4) Acknowledgments of KIT developers and contributors. AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 36 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Adult Education KW - Stakeholders KW - Mental Health Programs KW - Literature Reviews KW - Job Training KW - Supported Employment KW - Models KW - Job Skills KW - Citations (References) KW - Best Practices KW - Mental Disorders KW - Educational Opportunities KW - Program Implementation KW - Transitional Programs KW - Educational Practices KW - Educational Resources KW - Evidence KW - Employment Programs KW - Community Based Instruction (Disabilities) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322248077?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - Getting Started with Evidence-Based and Promising Practices. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322247936; ED540218 AB - Within a system, change affects stakeholders differently. Consequently, when making changes in the mental health system, mental health agencies should expect varied reactions from staff, community members, consumers, and families. Since misunderstandings can stymie efforts to implement evidence-based and promising practices, it is important to build consensus in the community. "Getting Started with Evidence-Based and Promising Practices" gives an overview of the activities that are generally involved in implementing evidence-based and promising practices and tells how to make them culturally competent. This booklet is particularly relevant to the following: (1) Mental health authorities; and (2) Agency staff who develop and manage these programs. A list of resources is included. AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 34 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Adult Education KW - Program Effectiveness KW - School Community Relationship KW - Stakeholders KW - Program Administration KW - Mental Health Programs KW - Mental Health KW - Needs Assessment KW - Integrated Activities KW - Educational Needs KW - Community Coordination KW - Best Practices KW - Program Attitudes KW - Agency Cooperation KW - Educational Resources KW - Cultural Relevance KW - Program Evaluation KW - Change Strategies KW - Organizational Change KW - Evidence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322247936?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - Building Your Program. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation) AN - 1322247877; ED540223 AB - "Building Your Program" is intended to help mental health authorities, agency administrators, and program leaders think through and develop Supported Education. The first part of this booklet gives you background information about the Supported Education model. Specific information about your role in implementing and sustaining Supported Education follows. Although you will work closely together to build your program, for ease, the author separated tips into two sections: (1) Tips for Mental Health Authorities; and (2) Tips for Agency Administrators and Program Leaders. In preparing this information, the author could think of no one better to advise you than people who have worked successfully with Supported Education. Therefore, the author based the information in this booklet on the experience of veteran program leaders, administrators, and consumers and end the booklet with words of advice. AU - Unger, Karen V. Y1 - 2011 PY - 2011 DA - 2011 SP - 54 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Administrators KW - Adult Education KW - Program Descriptions KW - Stakeholders KW - Program Design KW - Guidance Programs KW - Role Perception KW - Administrator Guides KW - Mental Health Programs KW - Mental Health KW - Sustainability KW - Design Preferences KW - Leaders Guides KW - Models KW - Institutional Role KW - Developmental Studies Programs KW - Program Guides KW - Best Practices KW - Transitional Programs KW - Program Implementation KW - Disabilities KW - Program Development KW - Evidence KW - Community Based Instruction (Disabilities) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322247877?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - An assessment of the impact of two distinct survey design modifications on health care utilization estimates in the medical expenditure panel survey AN - 1283640726; 201306485 AB - The Medical Expenditure Panel Survey (MEPS) is one of the core health care surveys that are a primary source for essential national healthcare utilization estimates. In 2007, the survey experienced two dominant survey design modifications: a new sample design attributable to the sample redesign of the National Health Interview Survey, and an upgrade to the Computer Assisted Personal Interview (CAPI) platform for the survey instrument, moving from a DOS to a Windows based environment. This study examines the impact of these survey design modifications on the national health care utilization estimates. Particular attention is given to assessing the level of convergence in utilization estimates based on the alternative designs as well as the alignment of model based analyses that discern which factors are associated with health care use. The paper concludes with a discussion of strategies that may yield additional improvements in the accuracy for these policy relevant survey estimates. Adapted from the source document. JF - Journal of Economic and Social Measurement AU - Cohen, Steven B AU - Ezzati-Rice, Trena M AU - Zodet, Marc AU - Machlin, Steven AU - Yu, William AD - Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road John M. Eisenberg Building, Rockville, MD, USA Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 33 EP - 69 PB - IOS Press, Amsterdam The Netherlands VL - 36 IS - 1-2 SN - 0747-9662, 0747-9662 KW - Health care utilization survey redesign MEPS KW - Alternative Approaches KW - Surveys KW - Health KW - Medicine KW - Health Care Utilization KW - Health Care Services KW - article KW - 2460: policy, planning, forecasting; social indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1283640726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+and+Social+Measurement&rft.atitle=An+assessment+of+the+impact+of+two+distinct+survey+design+modifications+on+health+care+utilization+estimates+in+the+medical+expenditure+panel+survey&rft.au=Cohen%2C+Steven+B%3BEzzati-Rice%2C+Trena+M%3BZodet%2C+Marc%3BMachlin%2C+Steven%3BYu%2C+William&rft.aulast=Cohen&rft.aufirst=Steven&rft.date=2011-01-01&rft.volume=36&rft.issue=1-2&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+Economic+and+Social+Measurement&rft.issn=07479662&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JEMEEZ N1 - SubjectsTermNotLitGenreText - Health Care Utilization; Health Care Services; Medicine; Surveys; Alternative Approaches; Health ER - TY - GEN T1 - Addressing Viral Hepatitis in People with Substance Use Disorders. Treatment Improvement Protocol (TIP) Series 53 AN - 1037910254; ED533526 AB - Treatment Improvement Protocols (TIPs) are developed by the Center for Substance Abuse Treatment (CSAT), part of the Substance Abuse and Mental Health Services Administration (SAMHSA) within the U.S. Department of Health and Human Services (HHS). Each TIP involves the development of topic-specific best-practice guidelines for the prevention and treatment of substance use and mental disorders. TIPs draw on the experience and knowledge of clinical, research, and administrative experts of various forms of treatment and prevention. TIPs are distributed to facilities and individuals across the country. Published TIPs can be accessed via the Internet at http://www.kap.samhsa.gov. Although each consensus-based TIP strives to include an evidence base for the practices it recommends, SAMHSA recognizes that behavioral health is continually evolving, and research frequently lags behind the innovations pioneered in the field. A major goal of each TIP is to convey "front-line" information quickly but responsibly. If research supports a particular approach, citations are provided. This TIP is organized into two parts: Part 1 is for counselors and administrators of behavioral health programs providing substance abuse treatment. It comprises seven chapters and emphasizes steps substance abuse treatment counselors and administrators can take to educate clients, prevent new hepatitis infections, and help clients who have viral hepatitis recover from their substance use disorders (SUDs). Information is provided at a basic level so that it can be understood by readers without medical training. Chapter 1 presents an overview of the most common types of viral hepatitis. Chapters 2 and 3 provide detailed information on screening for hepatitis and evaluation, respectively. Factors to consider when helping a client decide whether to undergo hepatitis treatment are addressed in Chapter 4; the treatment process is explained in Chapter 5. Chapter 6 describes counseling approaches for treating clients who have SUDs and viral hepatitis. Chapter 7 offers recommendations for administrators on how to add or improve hepatitis services, showcasing programs with proven track records. Note: Many people in treatment for SUDs are affected by mental disorders prior to the start of hepatitis treatment; mental disorders also may arise through the course of hepatitis treatment. Guidance for addressing co-occurring mental disorders is included throughout the TIP. Hepatitis-related issues specific to the treatment of mental disorders, not in the context of co-occurring SUDs, are covered in Appendix F. Part 2 is an online literature review for clinical supervisors, program administrators, and counselors interested in reviewing the medical literature on which this TIP is based. The literature review, available at http://www.kap.samhsa.gov, will be updated every 6 months for 5 years following publication of this TIP. Appended are: (1) Bibliography; (2) Glossary; (3) Hepatitis Resources; (4) Managing Side Effects of Hepatitis C Antiviral Treatment; (5) Medicinal Plants/Alternative Treatments Potentially Harmful to People Who Have Hepatitis; (6) Mental Health Treatment Considerations for People Who Have Chronic Viral Hepatitis C; (7) Motivational Interviewing and Counseling Resources; (8) Sources for Financial Assistance; (9) Hepatitis C Training Programs for Substance Abuse Treatment Program Staff; (10) Stakeholders Meeting Participants; (11) Field Reviewers; and (12) Acknowledgments. An index is included. (Contains 21 exhibits.) Y1 - 2011 PY - 2011 DA - 2011 SP - 146 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Counselors KW - Administrators KW - Social Influences KW - Counselor Role KW - Communicable Diseases KW - Barriers KW - Substance Abuse KW - Clinical Diagnosis KW - Chronic Illness KW - Readiness KW - Decision Making KW - Recidivism KW - Patient Education KW - Outcomes of Treatment KW - Comorbidity KW - Physician Patient Relationship KW - Genetics KW - Behavior Disorders KW - Mental Disorders KW - Ethics KW - Family Role KW - Immunization Programs KW - Acquired Immunodeficiency Syndrome (AIDS) KW - Program Evaluation KW - Medical Services KW - Outreach Programs KW - Legal Problems KW - Counselor Client Relationship KW - Drug Therapy KW - Therapy KW - Patients KW - Screening Tests KW - Needs KW - Prevention KW - Counseling Techniques KW - Diagnostic Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037910254?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Child Care and Development Fund: Report of State and Territory Plans, FY 2010-2011 AN - 1037910164; ED533821 AB - This report was prepared by the National Child Care Information and Technical Assistance Center (NCCIC) in partnership with staff from the Child Care Bureau. NCCIC compiled data reported in approved CCDF Plans and relevant attachments submitted by Lead Agencies for a selected number of questions. The information presented reflects some of the activities and strategies States and Territories planned to undertake as presented in the approved CCDF Plans. This report is not a catalog of all activities undertaken by Lead Agencies since States and Territories might not have included all activities in their CCDF Plans, which also may be amended at any time during the biennial period. In addition, this report includes some text taken directly from CCDF Plans, so certain terminology may differ in particular parts of the report given variations across States and Territories. Information is provided from 51 States and 5 Territories. For the purpose of this report, the District of Columbia is categorized as a State. The five Territories are American Samoa, the Commonwealth of the Northern Mariana Islands, Guam, Puerto Rico, and the Virgin Islands. Nearly all data in the tables and figures present combined information from States and Territories, rather than separate counts for each. The report includes two main sections ("Chapter 2: CCDF Plans Data Summary" and "Chapter 3: CCDF State and Territory Profiles"). The second chapter is a summary of selected data from all 56 Lead Agencies about how they comply with CCDF statute and Federal regulations, which corresponds to the CCDF Plan Preprint (Form ACF-118). Information is presented in table and figure format. The third chapter highlights selected services and activities through profiles of all States and Territories. These profiles present key information from the approved CCDF Plans about how the program is administered and implemented; eligibility criteria, reimbursement rates, and sliding fee scales; health and safety requirements; and selected activities to improve the quality of child care. These profiles provide examples for illustrative purposes as a supplement to the information presented in the second chapter. (Contains 42 tables, 2 figures and 1 footnote.) Y1 - 2011 PY - 2011 DA - 2011 SP - 178 PB - Child Care Bureau. US Department of Health and Human Services, Administration for Children & Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - American Samoa KW - Guam KW - Puerto Rico KW - Virgin Islands KW - Northern Mariana Islands KW - United States KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Elementary Education KW - Preschool Education KW - Toddlers KW - Federal Aid KW - Salaries KW - Educational Finance KW - Child Health KW - Professional Development KW - Child Care KW - State Aid KW - Fees KW - Certification KW - Quality Control KW - Financial Support KW - Grants KW - Child Safety KW - Eligibility KW - Foreign Countries KW - Profiles KW - Income Contingent Loans KW - Educational Policy KW - Standards KW - Family Income KW - Emergency Programs KW - Child Care Centers KW - Technical Assistance KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037910164?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Developmental exposure to endocrine-disrupting chemicals programs for reproductive tract alterations and obesity later in life AN - 1034811668; 16079731 AB - Many chemicals in the environment, especially those with estrogenic activity, are able to disrupt the programming of endocrine signaling pathways established during development; these chemicals are referred to as endocrine-disrupting chemicals. Altered programming can result in numerous adverse consequences in estrogen-target tissues, some of which may not be apparent until later in life. For example, a wide variety of structural, functional, and cellular effects have been identified in reproductive tract tissues. In addition to well-documented reproductive changes, obesity and diabetes have joined the list of adverse effects that have been associated with developmental exposure to environmental estrogens and other endocrine-disrupting chemicals. Obesity is a significant public health problem reaching epidemic proportions worldwide. Experimental animal studies document an association of developmental exposure to environmental estrogens and obesity. For example, a murine model of perinatal exposure to diethylstilbestrol has proven useful in studying mechanisms involved in abnormal programming of differentiating estrogen-target tissues, including reproductive tract tissues and adipocytes. Other environmental estrogens, including the environmental contaminant bisphenol A, have also been linked to reproductive problems and obesity later in life. Epidemiology studies support similar findings in humans, as do studies of cells in culture. Together, these findings suggest new targets for abnormal programming by estrogenic chemicals and provide evidence supporting the scientific concept termed the developmental origins of adult disease. Furthermore, the association of environmental estrogens with obesity and diabetes expands the focus on these diseases from intervention or treatment to include prevention or avoidance of chemical modifiers, especially during critical windows of development. JF - American Journal of Clinical Nutrition AU - Newbold, Retha R AD - From the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2011 PY - 2011 DA - 2011 SP - 1939S EP - 1942S PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 United States VL - 94 IS - 6 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Basic instruction program KW - Culture KW - Diabetes KW - Diseases KW - Estrogen KW - Obesity KW - Preventive health KW - Programs KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Developmental+exposure+to+endocrine-disrupting+chemicals+programs+for+reproductive+tract+alterations+and+obesity+later+in+life&rft.au=Newbold%2C+Retha+R&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2011-01-01&rft.volume=94&rft.issue=6&rft.spage=1939S&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Obesity; Culture; Programs; Preventive health; Estrogen; Basic instruction program; Diseases; Public health; Diabetes ER - TY - JOUR T1 - Adolescent and mid-life diet: risk of colorectal cancer in the NIH-AARP Diet and Health Study AN - 1032898859; 16079782 AB - BACKGROUND: Colorectal cancer has a natural history of several decades; therefore, the diet consumed decades before diagnosis may aid in understanding this malignancy. OBJECTIVE: The objective was to investigate diet during adolescence and 10 y before baseline (ages 40-61 y) in relation to colorectal cancer. DESIGN: Participants in the NIH-AARP Diet and Health Study (n = 292,797) completed a 124-item food-frequency questionnaire (FFQ) about diet in the past 12 mo and two 37-item FFQs about diet at ages 12-13 y and 10 y previously. Cox regression was used to estimate multivariate HRs and 95% CIs for colon (n = 2794) and rectal (n = 979) cancers within quintiles of exposures. RESULTS: Colon cancer risk was lower in the highest than in the lowest quintile of vitamin A (HR: 0.82; 95% CI: 0.72, 0.92) and vegetable (HR: 0.81, 0.70, 0.92) intakes during adolescence. Those in the highest intake category 10 y previously for calcium (HR: 0.83; 95% CI: 0.73, 0.94), vitamin A (HR: 0.81; 95% CI: 0.71, 0.92), vitamin C (HR: 0.83; 95% CI: 0.72, 0.95), fruit (HR: 0.84; 95% CI: 0.73, 0.97), and milk (HR: 0.78; 95% CI: 0.67, 0.90) had a lower risk of colon cancer, but a higher risk was observed for total fat (HR: 1.15; 95% CI: 1.01, 1.30), red meat (HR: 1.31; 95% CI: 1.12, 1.53), and processed meat (HR: 1.24; 95% CI: 1.06, 1.45). For rectal cancer, milk was inversely associated (HR: 0.75; 95% CI: 0.58, 0.96) with risk. CONCLUSION: Adolescent and midlife diet may play a role in colorectal carcinogenesis. JF - American Journal of Clinical Nutrition AU - Ruder, Elizabeth H AU - Thiebaut, Anne CM AU - Thompson, Frances E AU - Potischman, Nancy AU - Subar, Amy F AU - Park, Yikyung AU - Graubard, Barry I AU - Hollenbeck, Albert R AU - Cross, Amanda J AD - From the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD (EHR, YP, BIG, and AJC) Y1 - 2011 PY - 2011 DA - 2011 SP - 1607 EP - 1619 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 United States VL - 94 IS - 6 SN - 0002-9165, 0002-9165 KW - Health & Safety Science Abstracts KW - Adolescents KW - Age KW - Cancer KW - Colorectal carcinoma KW - Diets KW - Fruits KW - Meat KW - Milk KW - Vitamins KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1032898859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Adolescent+and+mid-life+diet%3A+risk+of+colorectal+cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Ruder%2C+Elizabeth+H%3BThiebaut%2C+Anne+CM%3BThompson%2C+Frances+E%3BPotischman%2C+Nancy%3BSubar%2C+Amy+F%3BPark%2C+Yikyung%3BGraubard%2C+Barry+I%3BHollenbeck%2C+Albert+R%3BCross%2C+Amanda+J&rft.aulast=Ruder&rft.aufirst=Elizabeth&rft.date=2011-01-01&rft.volume=94&rft.issue=6&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2012-08-24 N1 - SubjectsTermNotLitGenreText - Meat; Diets; Fruits; Age; Milk; Vitamins; Colorectal carcinoma; Adolescents; Cancer ER - TY - JOUR T1 - Development and Validation of the Mental Health Attitude Survey for Police AN - 1018376273; 201210328 AB - Police officers often lack sufficient mental health training and knowledge of mental illness to manage the risks associated with emotionally disturbed person (EDP) encounters. Still, it is not clear how much mental health training police officers actually need and, to date, there are no measures for police departments to use to determine officer attitudes toward dealing with EDPs. This led to the development of the Mental Health Attitude Survey for Police (MHASP), a modification and compilation of previously developed and newly developed items, which can be used to measure the effectiveness of mental health crisis training curricula in improving police attitudes toward persons with mental illnesses. A sample of 412 police officers from a major city police department in the northeast anonymously completed the MHASP. The results provide good evidence that the MHASP is a reliable and initially validated measure of police attitudes toward persons with mental illnesses. Adapted from the source document. JF - Community Mental Health Journal AU - Clayfield, Jonathan C AU - Fletcher, Kenneth E AU - Grudzinskas, Albert J AD - Department of Psychiatry, Center for Mental Health Services Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655-0002, USA jonathan.clayfield@umassmed.edu Y1 - 2011///0, PY - 2011 DA - 0, 2011 SP - 742 EP - 751 PB - Springer, Dordrecht The Netherlands VL - 47 IS - 6 SN - 0010-3853, 0010-3853 KW - Mental illness KW - Attitudes KW - Police officers KW - Mental health KW - Validation KW - Police KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018376273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Development+and+Validation+of+the+Mental+Health+Attitude+Survey+for+Police&rft.au=Clayfield%2C+Jonathan+C%3BFletcher%2C+Kenneth+E%3BGrudzinskas%2C+Albert+J&rft.aulast=Clayfield&rft.aufirst=Jonathan&rft.date=2011-01-01&rft.volume=47&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-011-9384-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Attitudes; Mental health; Police officers; Police; Mental illness; Validation DO - http://dx.doi.org/10.1007/s10597-011-9384-y ER - TY - JOUR T1 - Can Radiation Risks to Patients Be Reduced Without Reducing Radiation Exposure? The Status of Chemical Radioprotectants AN - 1017982284; 14403621 AB - OBJECTIVE: Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION: There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine. JF - American Journal of Roentgenology AU - Mettler, Fred A AU - Brenner, David AU - Coleman, CNorman AU - Kaminski, Joseph M AU - Kennedy, Ann R AU - Wagner, Louis K AD - Department of Radiology and Nuclear Medicine Service, New Mexico VA HealthCare Services, 1501 San Pedro Blvd. SE, Albuquerque, NM 87108. Department of Radiology, Columbia University, New York, NY. Department of Radiology, National Cancer Institute, National Institutes ofHealth, Rockville, MD. Division of Medical Imaging Products, Center for Drug Evaluation and Research,U.S. Food and Drug Administration, Silver Spring, MD. Department of Radiation Oncology, University of Pennsylvania School ofMedicine, Philadelphia, PA. Department of Radiology, University of Texas-Houston Medical School,Houston, TX. Y1 - 2011 PY - 2011 DA - 2011 SP - 616 EP - 618 PB - American Roentgen Ray Society VL - 196 IS - 3 SN - 0361-803X, 0361-803X KW - Toxicology Abstracts KW - Drugs KW - Radiation KW - Reviews KW - Stochasticity KW - terrorism KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017982284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=Can+Radiation+Risks+to+Patients+Be+Reduced+Without+Reducing+Radiation+Exposure%3F+The+Status+of+Chemical+Radioprotectants&rft.au=Mettler%2C+Fred+A%3BBrenner%2C+David%3BColeman%2C+CNorman%3BKaminski%2C+Joseph+M%3BKennedy%2C+Ann+R%3BWagner%2C+Louis+K&rft.aulast=Mettler&rft.aufirst=Fred&rft.date=2011-01-01&rft.volume=196&rft.issue=3&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - terrorism; Radiation; Reviews; Drugs; Stochasticity ER - TY - JOUR T1 - Remote sensing detection of atmospheric pollutants using lidar, sodar and correlation with air quality data in an industrial area AN - 1014107243; 16658538 AB - Optical remote sensing techniques have obvious advantages for monitoring gas and aerosol emissions, since they enable the operation over large distances, far from hostile environments, and fast processing of the measured signal. In this study two remote sensing devices, namely a Lidar (Light Detection and Ranging) for monitoring the vertical profile of backscattered light intensity, and a Sodar (Acoustic Radar, Sound Detection and Ranging) for monitoring the vertical profile of the wind vector were operated during specific periods. The acquired data were processed and compared with data of air quality obtained from ground level monitoring stations, in order to verify the possibility of using the remote sensing techniques to monitor industrial emissions. The campaigns were carried out in the area of the Environmental Research Center (Cepema) of the University of Sao Paulo, in the city of Cubatao, Brazil, a large industrial site, where numerous different industries are located, including an oil refinery, a steel plant, as well as fertilizer, cement and chemical/petrochemical plants. The local environmental problems caused by the industrial activities are aggravated by the climate and topography of the site, unfavorable to pollutant dispersion. Results of a campaign are presented for a 24- hour period, showing data of a Lidar, an air quality monitoring station and a Sodar. JF - Proceedings of SPIE - The International Society for Optical Engineering AU - Steffens, Juliana AU - Costa, Renata Fda AU - Landulfo, Eduardo AU - Guardani, Roberto AU - Paulo F. Moreira, Paulo FMoreira AU - Held, Gerhard Y1 - 2011 PY - 2011 DA - 2011 PB - SPIE, P.O. BOX 10 Bellingham WA 98227-0010 United States VL - 8182 SN - 0277-786X, 0277-786X KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Pollution monitoring KW - Atmospheric pollution KW - Acoustic radar KW - Remote sensing KW - Remote sensing techniques KW - Lidar KW - Air quality KW - Environmental research KW - Wind direction KW - Brazil, Sao Paulo KW - Air pollution KW - Oil KW - Brazil KW - Lidar applications KW - Industrial emissions KW - Urban areas KW - Technology KW - Topography KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014107243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.atitle=Remote+sensing+detection+of+atmospheric+pollutants+using+lidar%2C+sodar+and+correlation+with+air+quality+data+in+an+industrial+area&rft.au=Steffens%2C+Juliana%3BCosta%2C+Renata+Fda%3BLandulfo%2C+Eduardo%3BGuardani%2C+Roberto%3BPaulo+F.+Moreira%2C+Paulo+FMoreira%3BHeld%2C+Gerhard&rft.aulast=Steffens&rft.aufirst=Juliana&rft.date=2011-01-01&rft.volume=8182&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SPIE+-+The+International+Society+for+Optical+Engineering&rft.issn=0277786X&rft_id=info:doi/10.1117%2F12.897915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution; Acoustic radar; Lidar applications; Remote sensing techniques; Remote sensing; Environmental research; Air quality; Wind direction; Topography; Oil; Air pollution; Pollution monitoring; Lidar; Industrial emissions; Technology; Urban areas; Brazil, Sao Paulo; Brazil DO - http://dx.doi.org/10.1117/12.897915 ER - TY - JOUR T1 - Core body temperature in obesity AN - 1011203304; 14699350 AB - BACKGROUND: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. OBJECTIVE: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. DESIGN: In study 1, nonobese [body mass index (BMI; in kg/m2) <30] and obese (BMI greater than or equal to 30) adults swallowed wireless core temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for greater than or equal to 48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. RESULTS: Mean ( plus or minus SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 plus or minus 0.03 degree C compared with 36.89 plus or minus 0.03 degree C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature approximately 0.23 degree C greater than that of men (36.99 plus or minus 0.03 degree C compared with 36.76 plus or minus 0.03 degree C; P < 0.0001). CONCLUSIONS: Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500. JF - American Journal of Clinical Nutrition AU - Heikens, Marc J AU - Gorbach, Alexander M AU - Eden, Henry S AU - Savastano, David M AU - Chen, Kong Y AU - Skarulis, Monica C AU - Yanovski, Jack A AD - From the Unit on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (MJH, DMS, and JAY), the Biomedical Engineering and Physical Science Shared Resource, National Institute of Biomedical Imaging and Bioengineering (AMG and HSE), and the Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases (KYC and MCS), National Institutes of Health, US Department of Health and Human Services, Bethesda, MD Y1 - 2011 PY - 2011 DA - 2011 SP - 963 EP - 967 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California Davis CA 95616-8790 USA VL - 93 IS - 5 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Adults KW - Analysis KW - Body mass KW - Body temperature KW - Measurement KW - Nutrition KW - Obesity KW - Weight KW - Women KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011203304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Core+body+temperature+in+obesity&rft.au=Heikens%2C+Marc+J%3BGorbach%2C+Alexander+M%3BEden%2C+Henry+S%3BSavastano%2C+David+M%3BChen%2C+Kong+Y%3BSkarulis%2C+Monica+C%3BYanovski%2C+Jack+A&rft.aulast=Heikens&rft.aufirst=Marc&rft.date=2011-01-01&rft.volume=93&rft.issue=5&rft.spage=963&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Weight; Body temperature; Analysis; Body mass; Women; Adults; Nutrition ER - TY - JOUR T1 - Intramodality and Intermodality Comparisons of Storage Phosphor Computed Radiography and Conventional Film-Screen Radiography in the Recognition of Small Pneumoconiotic Opacities AN - 1008823902; 16109004 AB - BACKGROUND: Digital radiography systems are replacing traditional film for chest radiographic monitoring in the recognition of pneumoconiosis. METHODS: To further investigate previous findings regarding the equivalence of film-screen radiographs (FSRs) and storage phosphor computed radiographs (CRs), FSRs and CRs from 172 underground coal miners were classified independently by seven National Institute for Occupational Safety and Health-approved B readers, using the International Labor Office (ILO) classification of radiographs of pneumoconiosis. RESULTS: More CRs were classified as "good" quality compared with FSRs (prevalence ratio [PR], 1.5; 95% CI, 1.4-1.6; P , .001). B readers showed good overall agreement on scoring small opacity profusion using CRs vs FSRs (weighted Kappa , 0.58; 95% CI, 0.54-0.62). Significantly more irregular opacities (compared with rounded) were classified using CR images compared with FSR (PR, 1.3; 95% CI, 1.1-1.6; P = .01). Similarly, the smallest sized opacities (width < 1.5 mm, p and s type) were reported more frequently using CR vs FSR images (PR, 1.3; 95% CI, 1.1-1.5; P < .001). Interreader and intrareader agreement was lower with respect to the classification of shape and size than for small opacity profusion. Overall, interreader and intrareader variability did not differ significantly using CR vs FSR. CONCLUSIONS: Under optimal conditions, using standardized methods and equipment, reader visualization of small pneumoconiotic opacities does not appear to differ meaningfully, whether using CR or FSR. Variability in ILO classifications between imaging modalities appears to be considerably lower than variability among readers. The well-documented challenge of reader variability does not appear to be resolved through the use of digital imaging alone, and additional approaches must be evaluated. JF - Chest AU - Laney, AScott AU - Petsonk, Edward L AU - Attfield, Michael D AD - From the Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV Y1 - 2011 PY - 2011 DA - 2011 SP - 1574 EP - 1580 PB - American College of Chest Physicians, 3300 Dundee R. Northbrook IL 60062 United States VL - 140 IS - 6 SN - 0012-3692, 0012-3692 KW - Health & Safety Science Abstracts KW - Occupational safety KW - Pneumoconiosis KW - Coal KW - Storage KW - classification KW - Standards KW - Radiography KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008823902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Intramodality+and+Intermodality+Comparisons+of+Storage+Phosphor+Computed+Radiography+and+Conventional+Film-Screen+Radiography+in+the+Recognition+of+Small+Pneumoconiotic+Opacities&rft.au=Laney%2C+AScott%3BPetsonk%2C+Edward+L%3BAttfield%2C+Michael+D&rft.aulast=Laney&rft.aufirst=AScott&rft.date=2011-01-01&rft.volume=140&rft.issue=6&rft.spage=1574&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-04-23 N1 - SubjectsTermNotLitGenreText - Storage; Occupational safety; classification; Pneumoconiosis; Standards; Mining; Coal; Radiography ER - TY - JOUR T1 - Evolution and Population Structure of Salmonella enterica Serovar Newport AN - 856760814; 14045450 AB - Salmonellosis caused by Salmonella enterica serovar Newport is a major global public health concern, particularly because S. Newport isolates that are resistant to multiple drugs (MDR), including third-generation cephalosporins (MDR-AmpC phenotype), have been commonly isolated from food animals. We analyzed 384 S. Newport isolates from various sources by a multilocus sequence typing (MLST) scheme to study the evolution and population structure of the serovar. These were compared to the population structure of S. enterica serovars Enteritidis, Kentucky, Paratyphi B, and Typhimurium. Our S. Newport collection fell into three lineages, Newport-I, Newport-II, and Newport-III, each of which contained multiple sequence types (STs). Newport-I has only a few STs, unlike Newport-II or Newport-III, and has possibly emerged recently. Newport-I is more prevalent among humans in Europe than in North America, whereas Newport-II is preferentially associated with animals. Two STs of Newport-II encompassed all MDR-AmpC isolates, suggesting recent global spread after the acquisition of the blaCMY-2 gene. In contrast, most Newport-III isolates were from humans in North America and were pansusceptible to antibiotics. Newport was intermediate in population structure to the other serovars, which varied from a single monophyletic lineage in S. Enteritidis or S. Typhimurium to four discrete lineages within S. Paratyphi B. Both mutation and homologous recombination are responsible for diversification within each of these lineages, but the relative frequencies differed with the lineage. We conclude that serovars of S. enterica provide a variety of different population structures. JF - Journal of Bacteriology AU - Sangal, Vartul AU - Harbottle, Heather AU - Mazzoni, Camila J AU - Helmuth, Reiner AU - Guerra, Beatriz AU - Didelot, Xavier AU - Paglietti, Bianca AU - Rabsch, Wolfgang AU - Brisse, Sylvain AU - Weill, Francois-Xavier AU - Roumagnac, Philippe AU - Achtman, Mark AD - Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, D-10117 Berlin, Germany. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, United Kingdom. Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland 20708. Environmental Research Institute and Department of Microbiology, University College Cork, Cork, Ireland. National Salmonella Reference Laboratory, Federal Institute for Risk Assessment (BfR), Berlin, Germany. Department of Statistics, University of Oxford, Oxford OX1 3TG, United Kingdom. Department of Biomedical Sciences, University of Sassari, viale San Pietro 43/b, 07100 Sassari, Italy. National Reference Centre for Salmonellae and Other Enterics, Robert Koch Institute, Wernigerode, Germany. Institut Pasteur, Genotyping of Pathogens and Public Health, 28 rue du Dr Roux, 75724 Paris, France. Institut Pasteur, Unite des Bacteries Pathogenes Enteriques, Par Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 6465 EP - 6476 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 192 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Cephalosporins KW - Food KW - Antibiotics KW - Salmonella typhimurium KW - Public health KW - multilocus sequence typing KW - Paratyphis KW - Salmonella enterica KW - Salmonellosis KW - Population structure KW - homologous recombination KW - Drugs KW - Mutation KW - Evolution KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856760814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Evolution+and+Population+Structure+of+Salmonella+enterica+Serovar+Newport&rft.au=Sangal%2C+Vartul%3BHarbottle%2C+Heather%3BMazzoni%2C+Camila+J%3BHelmuth%2C+Reiner%3BGuerra%2C+Beatriz%3BDidelot%2C+Xavier%3BPaglietti%2C+Bianca%3BRabsch%2C+Wolfgang%3BBrisse%2C+Sylvain%3BWeill%2C+Francois-Xavier%3BRoumagnac%2C+Philippe%3BAchtman%2C+Mark&rft.aulast=Sangal&rft.aufirst=Vartul&rft.date=2010-12-15&rft.volume=192&rft.issue=24&rft.spage=6465&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Food; Salmonellosis; Antibiotics; Population structure; homologous recombination; Mutation; Drugs; Evolution; multilocus sequence typing; Public health; Paratyphis; Salmonella enterica; Salmonella typhimurium ER - TY - GEN T1 - Congratulations Dr. Rasmussen! AN - 846767244 AB - Mark Rasmussen was selected by the Center for Veterinary Medicine's Office of Research as its new director of the Division of Animal and Food Microbiology. As a research microbiologist, Rasmussen's scientific leadership will guide the division's expanding microbiology programs. JF - FDA Veterinarian AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 117 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Appointments & personnel changes KW - Veterinary medicine KW - Research KW - Rasmussen, Mark UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Congratulations+Dr.+Rasmussen%21&rft.au=McLean%2C+Melanie%2C+DVM&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - People - Rasmussen, Mark N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Approves Life-Saving Horse Drug AN - 846767243 AB - Led by the Office of New Animal Drug Evaluation, FDA's Center for Veterinary Medicine recently approved EQUIDONE (domperidone) Gel for the prevention of fescue toxicosis in pregnant mares. The approval of EQUIDONE Gel is important to the horse world because it is the first FDA-approved drug to prevent the devastating effects of fescue toxicosis. Veterinarians can prescribe EQUIDONE Gel for a mare at-risk for fescue toxicosis. JF - FDA Veterinarian AU - Oliver, Lynne, DVM AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 100 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - FDA approval KW - Horses KW - Drugs KW - Animal diseases KW - Disease prevention KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Approves+Life-Saving+Horse+Drug&rft.au=Oliver%2C+Lynne%2C+DVM%3BMcLean%2C+Melanie%2C+DVM&rft.aulast=Oliver&rft.aufirst=Lynne&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - The Power of Compassionate Giving AN - 846767242 AB - On Oct 18, 2010, FDA held the Combined Federal Campaign kick-off event at the agency's headquarters in White Oak, MD. The 2010 campaign theme is "The Compassion of Individuals, the Power of Community." The Combined Federal Campaign is the nation's leading fund-raising program. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 89 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Donations KW - Fund raising KW - Federal employees KW - Military personnel KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=The+Power+of+Compassionate+Giving&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Onboarding Program at CVM AN - 846767241 AB - On Oct 4, 2010, CVM's Office of Management started an onboarding program for new employees. The program, part of the center-wide Workforce Initiative, is a way to welcome newcomers to CVM and make them feel valued. The goal of CVM's onboarding program is for new employees to feel comfortable and well-adjusted in their new positions sooner than before. JF - FDA Veterinarian AU - Bradbury, Shannon Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 93 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Federal employees KW - Orientations KW - Work environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Onboarding+Program+at+CVM&rft.au=Bradbury%2C+Shannon&rft.aulast=Bradbury&rft.aufirst=Shannon&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Paper Trail - Citations for Journal Articles and Posters by CVM Scientists in 2010 AN - 846767240 AB - A listing of veterinary science study citations for journal articles and posters by Center for Veterinary Medicine scientists in 2010 is presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 78 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Veterinary medicine KW - Animal sciences KW - Studies KW - Government agencies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Paper+Trail+-+Citations+for+Journal+Articles+and+Posters+by+CVM+Scientists+in+2010&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Warning Letters - June 30 to October 28, 2010 AN - 846767239 AB - Several FDA warning letters from Jun 30-Oct 28, 2010 are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 62 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Federal regulation KW - Letters KW - Government agencies KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Warning+Letters+-+June+30+to+October+28%2C+2010&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Drug Approvals - August to December, 2010 AN - 846767238 AB - A listing of FDA animal drug approvals from the month of August to December 2010 is presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 74 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine KW - Animal diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Drug+Approvals+-+August+to+December%2C+2010&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Pet Food Safety - Paws Up for Progress AN - 846767237 AB - A Pet Food Early Warning Surveillance System was created as part of the 2007 Food and Drug Administration Amendments Act, whose goal is to quickly identify contaminated pet food and illness outbreaks associated with pet food. Here, O'Neill and McLean highlight how veterinarians who use the portal to report pet food-related problems take an active role in detecting and controlling foodborne diseases in the nation's companion animals. JF - FDA Veterinarian AU - O'Neill, Gail AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 44 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Animal care KW - Food safety KW - Pets KW - Veterinary services KW - Law KW - Surveillance KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Pet+Food+Safety+-+Paws+Up+for+Progress&rft.au=O%27Neill%2C+Gail%3BMcLean%2C+Melanie%2C+DVM&rft.aulast=O%27Neill&rft.aufirst=Gail&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OSC Reports on Antimicrobials Sold and Distributed for Food-Producing Animals AN - 846767188 AB - In December 2010, CVM's Office of Surveillance & Compliance published a summary of the 2009 sales and distribution data for antimicrobial drugs approved by FDA for use in food-producing animals. Section 105 of the Animal Drug User Fee Amendments of 2008, called "ADUFA 105," requires drug sponsors to report to CVM the amount of antimicrobial drugs they sell or distribute each year for use in food-producing animals. Under ADUFA 105, CVM must summarize the yearly sales and distribution data received by the center from the drug sponsors. JF - FDA Veterinarian AU - Hartogensis, Martine, DVM AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 107 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Antimicrobial agents KW - Animal diseases KW - FDA approval UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OSC+Reports+on+Antimicrobials+Sold+and+Distributed+for+Food-Producing+Animals&rft.au=Hartogensis%2C+Martine%2C+DVM%3BMcLean%2C+Melanie%2C+DVM&rft.aulast=Hartogensis&rft.aufirst=Martine&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OSC Ends 2010 with an Expansion AN - 846767187 AB - In November 2010, CVM's Office of Surveillance & Compliance (OS&C) created the Division of Veterinary Product Safety, or DVPS. Analysts in this new division monitor CVM's database of adverse events reported for approved and unapproved animal drugs, pet food, and animal devices. The work done by the three teams in OS&C's new Division of Veterinary Product Safety supports CVM's mission to protect human and animal health. JF - FDA Veterinarian AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 110 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Pet food KW - Veterinary services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OSC+Ends+2010+with+an+Expansion&rft.au=McLean%2C+Melanie%2C+DVM&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Center for Veterinary Medicine Timeline AN - 846767186 AB - A timeline of historic events that happened in the Center for Veterinary Medicine from 1906 to 2011 is presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 58 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - History KW - Government agencies KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Center+for+Veterinary+Medicine+Timeline&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Ask Dr. Dunham: Answers to Some of CVM's Most Frequently Asked Questions AN - 846767185 AB - Dunham answers three of the most frequently asked questions at the Center for Veterinary Medicine's Website. Among other things, she informs that it is illegal to sell turtles smaller than 4 inches in the US. In addition, unapproved animal drugs may not meet FDA's strict standards for safety and effectiveness. JF - FDA Veterinarian AU - Dunham, Bernadette, DVM, PhD Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 54 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Veterinary medicine KW - Animal diseases KW - Animal care KW - Web sites KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Ask+Dr.+Dunham%3A+Answers+to+Some+of+CVM%27s+Most+Frequently+Asked+Questions&rft.au=Dunham%2C+Bernadette%2C+DVM%2C+PhD&rft.aulast=Dunham&rft.aufirst=Bernadette&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Take the "Oh No!" Out of Your and Your Pets' Holiday "Ho-Ho-Ho!" AN - 846767184 AB - Stamper talks about pet treats that may pose a threat to pet's life during holidays when chewed. Pet treats that get stuck in a pet's trachea (windpipe), pet starts becoming frantic, start drooling and choking, an emergency visit to a veterinarian is advised. JF - FDA Veterinarian AU - Stamper, Carmela, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 36 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Veterinarians KW - Veterinary medicine KW - Pets KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Take+the+%22Oh+No%21%22+Out+of+Your+and+Your+Pets%27+Holiday+%22Ho-Ho-Ho%21%22&rft.au=Stamper%2C+Carmela%2C+DVM&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Holds Public Meeting on GE Salmon AN - 846767183 AB - The FDA held a Veterinary Medicine Advisory Committee meeting on an application for approval of AquAdvantage Salmon, a genetically engineered (GE) Atlantic salmon produced by AquaBounty Technologies Inc. The salmon is bred to grow faster than non-GE Atlantic salmon, and if approved, will be the first genetically engineered animal intended for human food. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 50 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - FDA approval KW - Genetic engineering KW - Salmon KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Holds+Public+Meeting+on+GE+Salmon&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA; AquaBounty Technologies N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA's Role in Animal Health - Yes! No! Maybe So! - What FDA Does and Does Not Regulate AN - 846767180 AB - The Federal Food, Drug, and Cosmetic Act gives FDA the legal authority to approve and regulate drugs for animals. Before a drug company can market an animal drug, the company must get the drug approved by FDA. Appropriate resources directing consumers that FDA and other organization are responsible for protecting animal health are presented. JF - FDA Veterinarian AU - Steel, Ashley Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 28 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - FDA approval KW - Animal care KW - Organizations KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA%27s+Role+in+Animal+Health+-+Yes%21+No%21+Maybe+So%21+-+What+FDA+Does+and+Does+Not+Regulate&rft.au=Steel%2C+Ashley&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Congratulations Dr. Myers! AN - 846767177 AB - FDA Commissioner Dr. Margaret Hamburg recently appointed Dr. Michael Myers, a research pharmacologist in CVM's Office of Research (OR), to the Senior Biomedical Research Service. CVM recruited Myers in 1990 to develop an immunology research program at OR. Along with leading the immunology and animal protein detection programs, Myers chaired OR's Institutional Animal Care and Use Committee for 15 years, moving to vice-chair in 200. JF - FDA Veterinarian AU - Stamper, Carmela, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 113 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Government agencies KW - Appointments & personnel changes KW - Veterinary medicine KW - Biomedical research KW - Myers, Michael UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Congratulations+Dr.+Myers%21&rft.au=Stamper%2C+Carmela%2C+DVM&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-12-15&rft.volume=&rft.issue=&rft.spage=vii%2B202&rft.isbn=0275931749&rft.btitle=COPING+WITH+CULTURAL+AND+RACIAL+DIVERSITY+IN+URBAN+AMERICA&rft.title=COPING+WITH+CULTURAL+AND+RACIAL+DIVERSITY+IN+URBAN+AMERICA&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - People - Myers, Michael N1 - Last updated - 2011-06-21 ER - TY - JOUR T1 - Lactational transfer of bisphenol A in Sprague-Dawley rats. AN - 812137153; 20933065 AB - Bisphenol A (BPA), an important industrial chemical to which humans are exposed on a daily basis, has long been associated with endocrine disruption in experimental animal models. Such exposures are of concern, particularly during fetal and early neonatal periods, because of greater vulnerability of developing organs to aberrant endocrine signaling. Although rarely reported, information about internal exposures to the receptor-active aglycone form of BPA during the perinatal period is essential to accurate assessment of potential risks. Lactating Sprague-Dawley dams were treated by daily gavage with 100 μg/kg bw d6-BPA starting at birth. Conjugated and aglycone forms of BPA were then measured by using LC/MS/MS in milk from lactating dams on PND 7 and in serum from dams and their pups on PND 10. All samples were collected 1h after dosing, a time selected to produce nearly maximal levels. While aglycone BPA was detected in all dam serum and milk samples, none was detected in pup serum (<0.2 nM). Doses delivered to pups lactationally, estimated from milk concentrations and body weights, were 300-fold lower than the dose administered to the dams. Similarly, serum concentrations of total BPA in pups were 300-fold lower than those in their dams. Furthermore, plasma concentrations of total BPA in PND 10 rat pups were 500-fold lower than peak levels achieved following direct oral delivery of the same dose to the same age pups. These findings of significant dose attenuation for the active aglycone form of BPA, relative to that of the dam, suggest high potency for toxicological effects derived exclusively from lactational transfer. Alternatively, studies that include lactational exposure and report minimal effects from BPA should consider the possibility that inadequate internal exposures were achieved during the critical postnatal period. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Doerge, Daniel R AU - Vanlandingham, Michelle AU - Twaddle, Nathan C AU - Delclos, K Barry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCRT Road, Jefferson, AR 72079, USA. daniel.doerge@fda.hhs.gov Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 372 EP - 376 VL - 199 IS - 3 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Chromatography, Liquid KW - Biological Transport KW - Tandem Mass Spectrometry KW - Female KW - Lactation KW - Milk -- metabolism KW - Phenols -- pharmacokinetics KW - Phenols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812137153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Lactational+transfer+of+bisphenol+A+in+Sprague-Dawley+rats.&rft.au=Doerge%2C+Daniel+R%3BVanlandingham%2C+Michelle%3BTwaddle%2C+Nathan+C%3BDelclos%2C+K+Barry&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2010-12-15&rft.volume=199&rft.issue=3&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2010.09.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-17 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2010.09.022 ER -