TY - CPAPER T1 - A Us Fda Perspective on Safety Biomarkers and the Qualification Process T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313115003; 6137491 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Walton, M Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Bioindicators KW - FDA KW - biomarkers KW - Biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313115003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=A+Us+Fda+Perspective+on+Safety+Biomarkers+and+the+Qualification+Process&rft.au=Walton%2C+M&rft.aulast=Walton&rft.aufirst=M&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - In Vitro/in Silico/Exploratory Assessment of Pharmaceuticals T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313114770; 6137093 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Jacobs, A Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313114770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=In+Vitro%2Fin+Silico%2FExploratory+Assessment+of+Pharmaceuticals&rft.au=Jacobs%2C+A&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Multilaboratory Assessment of Best Practices for Measuring Injuryassociated Micrornas in Biofluids Using a Model of Isoproterenolinduced Myocardial Injury in Rats T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313106962; 6137310 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Thompson, K AU - Bauer, Y AU - Chen, T AU - Couttet, P AU - Ellinger-Ziegelbauer, H AU - Kanki, M AU - Leonard, J AU - Nassirpour, R AU - Searfoss, G AU - Sharapova, T AU - Kelsall, J AU - Uchiyama, H AU - Yuen, P AU - Spire, C AU - O'Lone, R Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Best practices KW - Injuries KW - Rats KW - miRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313106962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Multilaboratory+Assessment+of+Best+Practices+for+Measuring+Injuryassociated+Micrornas+in+Biofluids+Using+a+Model+of+Isoproterenolinduced+Myocardial+Injury+in+Rats&rft.au=Thompson%2C+K%3BBauer%2C+Y%3BChen%2C+T%3BCouttet%2C+P%3BEllinger-Ziegelbauer%2C+H%3BKanki%2C+M%3BLeonard%2C+J%3BNassirpour%2C+R%3BSearfoss%2C+G%3BSharapova%2C+T%3BKelsall%2C+J%3BUchiyama%2C+H%3BYuen%2C+P%3BSpire%2C+C%3BO%27Lone%2C+R&rft.aulast=Thompson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Epigenetic and Mirna Dysregulation in Liver Nongenotoxic and Genotoxic Tumorigenesis T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313098189; 6137362 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Kutanzi, K AU - Melnyk, S AU - Koturbash, I AU - Pogribny, I Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Genotoxicity KW - Liver KW - miRNA KW - Tumorigenesis KW - epigenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313098189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Epigenetic+and+Mirna+Dysregulation+in+Liver+Nongenotoxic+and+Genotoxic+Tumorigenesis&rft.au=Kutanzi%2C+K%3BMelnyk%2C+S%3BKoturbash%2C+I%3BPogribny%2C+I&rft.aulast=Kutanzi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Use of Computational Toxicology Tools and Databases at the Fda, Office of Food Additive Safety T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313088570; 6137024 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Arvidson, K Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Food additives KW - Toxicology KW - FDA KW - Databases KW - Computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313088570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Regulatory+Use+of+Computational+Toxicology+Tools+and+Databases+at+the+Fda%2C+Office+of+Food+Additive+Safety&rft.au=Arvidson%2C+K&rft.aulast=Arvidson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspectives of Contemporary Issues in Ocular Toxicology T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313073678; 6137107 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Chambers, W Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313073678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Regulatory+Perspectives+of+Contemporary+Issues+in+Ocular+Toxicology&rft.au=Chambers%2C+W&rft.aulast=Chambers&rft.aufirst=W&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Recognition of Nanoparticles by Macrophages--from Principles to Consequences and Toxicity T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313032865; 6137117 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Shvedova, A Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Toxicity KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313032865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Recognition+of+Nanoparticles+by+Macrophages--from+Principles+to+Consequences+and+Toxicity&rft.au=Shvedova%2C+A&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Immunomodulation and Cancer: A Regulatory Perspective T2 - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AN - 1313025216; 6137042 JF - 51st Annual Meeting of the Society of Toxicology (SOT 2012) AU - Mellon, D Y1 - 2012/03/11/ PY - 2012 DA - 2012 Mar 11 KW - Cancer KW - Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313025216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Immunomodulation+and+Cancer%3A+A+Regulatory+Perspective&rft.au=Mellon%2C+D&rft.aulast=Mellon&rft.aufirst=D&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/PUB/Program12.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The effect of hepatitis C treatment and human immunodeficiency virus (HIV) co-infection on the disease burden of hepatitis C among injecting drug users in Amsterdam AN - 928988935; 4279043 AB - Aims The hepatitis C virus (HCV) disease burden among injecting drug users (IDUs) is determined by HCV incidence, the long latency period of HCV, competing mortality causes, presence of co-infection and HCV treatment uptake. We examined the effect of these factors and estimated the HCV disease burden in Amsterdam. Design A Markov model was developed, incorporating HCV and human immunodeficiency virus (HIV), and parameterized with data from the Amsterdam Cohort Studies, surveillance studies and literature. Setting IDU population of Amsterdam. Measurements HCV infection simulated from its acute phase to HCV-related liver disease (i.e. decompensated cirrhosis and hepatocellular carcinoma). Findings The HCV prevalence among IDUs in Amsterdam increased to approximately 80% in the 1980s. From 2011 to 2025, the HCV-related disease prevalence will accordingly rise by 36%, from 57 cases (95% range 33–94) to 78 (95% range 43–138), respectively. In total, 945 (95% range 617–1309) individuals will develop HCV-related liver disease. This burden would have been 33% higher in the absence of HIV, resulting in 1219 cases (95% range 796–1663). In Amsterdam, 25% of HIV-negative IDUs receive successful HCV treatment, reducing the cumulative disease burden by 14% to 810 (95% range 520–1120). Further reduction of 36% can be achieved by improving treatment, resulting in 603 cases (95% range 384–851). Conclusions The hepatitis C virus burden among injecting drug users in Amsterdam has been reduced by a high competing mortality rate, particularly caused by HIV infection, and to a smaller extent by hepatitis C virus treatment. Improved hepatitis C virus treatment is expected to contribute to reduce the future hepatitis C virus disease burden. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Coutinho, Roel AU - Prins, Maria AU - Matser, Amy AU - Urbanus, Anouk AU - Geskus, Ronald AU - Kretzschmar, Mirjam AU - Xiridou, Maria AU - Buster, Marcel AD - Amsterdam Public Health Service ; Academic Medical Centre ; Utrecht University ; National Institute of Public Health and the Environment, Netherlands Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 614 EP - 623 VL - 107 IS - 3 SN - 0965-2140, 0965-2140 KW - Sociology KW - Hepatitis KW - Medical care KW - AIDS KW - Liver KW - Medical treatment KW - Diseases KW - Netherlands KW - HIV KW - Illness KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/928988935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+effect+of+hepatitis+C+treatment+and+human+immunodeficiency+virus+%28HIV%29+co-infection+on+the+disease+burden+of+hepatitis+C+among+injecting+drug+users+in+Amsterdam&rft.au=Coutinho%2C+Roel%3BPrins%2C+Maria%3BMatser%2C+Amy%3BUrbanus%2C+Anouk%3BGeskus%2C+Ronald%3BKretzschmar%2C+Mirjam%3BXiridou%2C+Maria%3BBuster%2C+Marcel&rft.aulast=Coutinho&rft.aufirst=Roel&rft.date=2012-03-01&rft.volume=107&rft.issue=3&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2011.03654.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5810 3617 6220; 5703 3617 6220; 482 3617 6220; 7890 5792 10484; 7875 5775 13521; 3617 6220; 10449 5772; 7473 1678; 6220; 275 462 129 DO - http://dx.doi.org/10.1111/j.1360-0443.2011.03654.x ER - TY - JOUR T1 - Medicare managed care and primary care quality: examining racial/ethnic effects across states AN - 926885604; 16381256 AB - The study assesses the role of Medicare Advantage (MA) plans in providing quality primary care in comparison to FFS Medicare in three states, New York, California, Florida, across three racial ethnic groups. The performance is measured in terms of providing better quality primary care, as defined by lowering the risks of preventable hospital admissions. Using 2004 hospital discharge data (HCUP-SID) of Agency for Healthcare Research and Quality for three states, a multivariate cross sectional design is used with individual admission as the unit of analysis. The study found that MA plans were associated with lower preventable hospitalizations relative to marker admissions. The benefit also spilled over to different racial and ethnic subgroups and in some states, e.g. CA and FL, MA enrollment was associated with significantly lower odds of minority admissions than of white admissions. These results may indicate a potentially favorable role of MA plans in attenuating racial/ethnic inequalities in primary care in some states. JF - Health Care Management Science AU - Basu, Jayasree AD - Center for Primary care, Prevention, and Clinical Partnerships Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, 20850, USA, Jayasree.basu@ahrq.hhs.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 15 EP - 28 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 15 IS - 1 SN - 1386-9620, 1386-9620 KW - Risk Abstracts KW - Ethnic groups KW - Health care KW - Hospitals KW - USA, Florida KW - USA, New York KW - USA, California KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926885604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Regulatory+Perspective+on+Continuous+Manufacturing&rft.au=Chatterjee%2C+Sharmista&rft.aulast=Chatterjee&rft.aufirst=Sharmista&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Health care; Ethnic groups; Hospitals; USA, Florida; USA, California; USA, New York DO - http://dx.doi.org/10.1007/s10729-011-9176-5 ER - TY - JOUR T1 - Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus. AN - 922761235; 22348907 AB - Probiotic lactic acid bacteria (LAB) have been shown to alleviate inflammation, enhance the immunogenicity of rotavirus vaccines, or reduce the severity of rotavirus diarrhoea. Although the mechanisms are not clear, the differential Th1/Th2/Th3-driving capacities and modulating effects on cytokine production of different LAB strains may be the key. Our goal was to delineate the influence of combining two probiotic strains of Lactobacillus acidophilus and Lactobacillus reuteri on the development of cytokine responses in neonatal gnotobiotic pigs infected with human rotavirus (HRV). We demonstrated that HRV alone, or HRV plus LAB, but not LAB alone, initiated serum cytokine responses, as indicated by significantly higher concentrations of IFN-α, IFN-γ, IL-12, and IL-10 at postinoculation day (PID) 2 in the HRV only and LAB+HRV+ pigs compared to LAB only and LAB-HRV- pigs. Peak cytokine responses coincided with the peak of HRV replication. LAB further enhanced the Th1 and Th2 cytokine responses to HRV infection as indicated by significantly higher concentrations of IL-12, IFN-γ, IL-4 and IL-10 in the LAB+HRV+ pigs compared to the LAB-HRV+ pigs. The LAB+HRV+ pigs maintained relatively constant concentrations of TGF-β compared to the HRV only group which had a significant increase at PID 2 and decrease at PID 7, suggesting a regulatory role of LAB in maintaining gut homeostasis. At PID 28, cytokine secreting cell (CSC) responses, measured by ELISpot, showed increased Th1 (IL-12, IFN-γ) CSC numbers in the LAB+HRV+ and LAB-HRV+ groups compared to LAB only and LAB-HRV- pigs, with significantly increased IL-12 CSCs in spleen and PBMCs and IFN-γ CSCs in spleen of the LAB+HRV+ group. Thus, HRV infection alone, but not LAB alone was effective in inducing cytokine responses but LAB significantly enhanced both Th1 and Th2 cytokines in HRV-infected pigs. LAB may also help to maintain immunological homeostasis during HRV infection by regulating TGF-β production. JF - Beneficial microbes AU - Azevedo, M S P AU - Zhang, W AU - Wen, K AU - Gonzalez, A M AU - Saif, L J AU - Yousef, A E AU - Yuan, L AD - US Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA. Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 33 EP - 42 VL - 3 IS - 1 KW - Cytokines KW - 0 KW - Index Medicus KW - Th1 Cells -- immunology KW - Animals KW - Germ-Free Life KW - Probiotics -- administration & dosage KW - Diarrhea -- immunology KW - Enzyme-Linked Immunospot Assay KW - Diarrhea -- virology KW - Spleen -- immunology KW - Spleen -- virology KW - Th2 Cells -- immunology KW - Intestines -- microbiology KW - Intestines -- immunology KW - Swine -- microbiology KW - Rotavirus -- immunology KW - Lactobacillus reuteri -- immunology KW - Swine -- immunology KW - Lactobacillus acidophilus -- immunology KW - Rotavirus -- pathogenicity KW - Cytokines -- immunology KW - Swine -- virology KW - Rotavirus Infections -- immunology KW - Rotavirus Infections -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/922761235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Beneficial+microbes&rft.atitle=Lactobacillus+acidophilus+and+Lactobacillus+reuteri+modulate+cytokine+responses+in+gnotobiotic+pigs+infected+with+human+rotavirus.&rft.au=Azevedo%2C+M+S+P%3BZhang%2C+W%3BWen%2C+K%3BGonzalez%2C+A+M%3BSaif%2C+L+J%3BYousef%2C+A+E%3BYuan%2C+L&rft.aulast=Azevedo&rft.aufirst=M+S&rft.date=2012-03-01&rft.volume=3&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Beneficial+microbes&rft.issn=1876-2891&rft_id=info:doi/10.3920%2FBM2011.0041 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-14 N1 - Date created - 2012-02-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Nutr. 2000 Feb;130(2S Suppl):396S-402S [10721914] PLoS Comput Biol. 2011 Jul;7(7):e1002122 [21829337] Microbes Infect. 2001 Sep;3(11):947-54 [11564443] J Immunol. 2002 Jan 1;168(1):171-8 [11751960] Pediatrics. 2002 Apr;109(4):678-84 [11927715] Gut. 2002 May;50 Suppl 3:III54-9 [11953334] Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):147-60 [12072229] Pediatr Infect Dis J. 2002 May;21(5):411-6 [12150178] Curr Pharm Des. 2003;9(2):175-91 [12570667] Clin Diagn Lab Immunol. 2003 Nov;10(6):995-1001 [14607858] Clin Diagn Lab Immunol. 2004 Jan;11(1):12-20 [14715539] Clin Exp Immunol. 1990 Apr;80(1):49-55 [2157566] Br J Nutr. 1990 Jul;64(1):71-9 [2119224] Pediatrics. 1991 Jul;88(1):90-7 [1905394] J Immunol. 1993 May 1;150(9):3990-4000 [8386204] Gut. 1994 Jul;35(7):934-40 [8063221] J Virol. 1996 May;70(5):3075-83 [8627786] J Gen Virol. 1996 Jul;77 ( Pt 7):1431-41 [8757984] Acta Paediatr. 1997 May;86(5):460-5 [9183482] J Pediatr Gastroenterol Nutr. 1997 Nov;25(5):516-9 [9360205] Appl Microbiol. 1964 Jul;12:295-300 [14199016] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2880-5 [15710900] J Virol. 2006 Jan;80(1):372-82 [16352562] Clin Vaccine Immunol. 2006 Mar;13(3):365-75 [16522779] J Physiol Pharmacol. 2006 Nov;57 Suppl 9:13-21 [17242484] Clin Nutr. 2007 Aug;26(4):450-9 [17544549] Curr Opin Gastroenterol. 2007 Nov;23(6):679-92 [17906447] Int Immunol. 2007 Dec;19(12):1319-27 [17951600] Vet Immunol Immunopathol. 2008 Feb 15;121(3-4):222-31 [18006076] Vet Immunol Immunopathol. 2008 Mar 15;122(1-2):175-81 [18023882] Vaccine. 2008 Jun 19;26(26):3322-31 [18456375] Vaccine. 2008 Jul 4;26(29-30):3655-61 [18524434] Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19474-9 [19047644] Am J Respir Crit Care Med. 2009 Feb 1;179(3):186-93 [19029003] Vet Immunol Immunopathol. 2009 Feb 15;127(3-4):304-15 [19054578] Viral Immunol. 2010 Apr;23(2):135-49 [20373994] Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):267-75 [21489639] J Dairy Sci. 2001 Feb;84(2):319-31 [11233016] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3920/BM2011.0041 ER - TY - JOUR T1 - (Q)SAR modeling and safety assessment in regulatory review. AN - 922501343; 22258468 AB - The ability to predict clinical safety based on chemical structures is becoming an increasingly important part of regulatory decision making. (Quantitative) structure-activity relationship ((Q)SAR) models are currently used to evaluate late-arising safety concerns and possible nonclinical effects of a drug and its related compounds when adequate safety data are absent or equivocal. Regulatory use will likely increase with the standardization of analytical approaches, more complete and reliable data collection methods, and a better understanding of toxicity mechanisms. JF - Clinical pharmacology and therapeutics AU - Kruhlak, N L AU - Benz, R D AU - Zhou, H AU - Colatsky, T J AD - Division of Drug Safety Research, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 529 EP - 534 VL - 91 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Drug and Narcotic Control -- methods KW - Decision Making KW - Drug Industry -- methods KW - Models, Theoretical KW - Quantitative Structure-Activity Relationship KW - Drug-Related Side Effects and Adverse Reactions KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/922501343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Challenges+in+Development+of+Melamine+Analysis+in+Food+Contamination&rft.au=Krynitsky%2C+Alexander&rft.aulast=Krynitsky&rft.aufirst=Alexander&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-26 N1 - Date created - 2012-02-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2011.300 ER - TY - JOUR T1 - Environmental fate of polyhexamethylene biguanide. AN - 921424785; 22037631 AB - Polyhexamethylene biguanide (PHMB) is used as a bacteriocidal agent in a variety of applications from medical devices to pools, but is highly toxic to some aquatic species. The stability of PHMB in various environmental matrices was examined. 80% of PHMB was present in fortified creek samples after 20 days, but bound immediately to soils with the exception of sandy soil. PHMB was absorbed to below detectable levels by weathered concrete within 12 h. In addition, one over the counter wound care product containing PHMB was evaluated to assess environmental leaching; detectable levels (20 μg/mL) were still present after 1 week. JF - Bulletin of environmental contamination and toxicology AU - Lucas, Anne D AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, OSEL/DB, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. anne.lucas@fda.hhs.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 322 EP - 325 VL - 88 IS - 3 KW - Anti-Bacterial Agents KW - 0 KW - Biguanides KW - Soil KW - Soil Pollutants KW - Water Pollutants, Chemical KW - polihexanide KW - 322U039GMF KW - Index Medicus KW - Environmental Monitoring KW - Fresh Water -- chemistry KW - Equipment and Supplies KW - Kinetics KW - Soil -- chemistry KW - Water Pollutants, Chemical -- analysis KW - Anti-Bacterial Agents -- analysis KW - Biguanides -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/921424785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+environmental+contamination+and+toxicology&rft.atitle=Environmental+fate+of+polyhexamethylene+biguanide.&rft.au=Lucas%2C+Anne+D&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2012-03-01&rft.volume=88&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+environmental+contamination+and+toxicology&rft.issn=1432-0800&rft_id=info:doi/10.1007%2Fs00128-011-0436-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-30 N1 - Date created - 2012-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00128-011-0436-3 ER - TY - JOUR T1 - Perfluorinated compounds and subfecundity in pregnant women. AN - 921143530; 22081060 AB - Perfluorinated compounds are ubiquitous pollutants; epidemiologic data suggest they may be associated with adverse health outcomes, including subfecundity. We examined subfecundity in relation to 2 perfluorinated compounds-perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA). This case-control analysis included 910 women enrolled in the Norwegian Mother and Child Cohort Study in 2003 and 2004. Around gestational week 17, women reported their time to pregnancy and provided blood samples. Cases consisted of 416 women with a time to pregnancy greater than 12 months, considered subfecund. Plasma concentrations of perfluorinated compounds were analyzed using liquid chromatography-mass spectrometry. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for each pollutant quartile using logistic regression. Estimates were further stratified by parity. The median plasma concentration of PFOS was 13.0 ng/mL (interquartile range [IQR] = 10.3-16.6 ng/mL) and of PFOA was 2.2 ng/mL (IQR = 1.7-3.0 ng/mL). The relative odds of subfecundity among parous women was 2.1 (95% CI = 1.2-3.8) for the highest PFOS quartile and 2.1 (1.0-4.0) for the highest PFOA quartile. Among nulliparous women, the respective relative odds were 0.7 (0.4-1.3) and 0.5 (0.2-1.2). Previous studies suggest that the body burden of perfluorinated compounds decreases during pregnancy and lactation through transfer to the fetus and to breast milk. Afterward, the body burden may increase again. Among parous women, increased body burden may be due to a long interpregnancy interval rather than the cause of a long time to pregnancy. Therefore, data from nulliparous women may be more informative regarding toxic effects of perfluorinated compounds. Our results among nulliparous women did not support an association with subfecundity. JF - Epidemiology (Cambridge, Mass.) AU - Whitworth, Kristina W AU - Haug, Line S AU - Baird, Donna D AU - Becher, Georg AU - Hoppin, Jane A AU - Skjaerven, Rolv AU - Thomsen, Cathrine AU - Eggesbo, Merete AU - Travlos, Gregory AU - Wilson, Ralph AU - Longnecker, Matthew P AD - Department of Health and Human Services, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA. whitworthkw@niehs.nih.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 257 EP - 263 VL - 23 IS - 2 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - Parity KW - Odds Ratio KW - Norway -- epidemiology KW - Pregnancy -- drug effects KW - Logistic Models KW - Humans KW - Body Burden KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Case-Control Studies KW - Female KW - Caprylates -- blood KW - Caprylates -- adverse effects KW - Fluorocarbons -- blood KW - Fluorocarbons -- adverse effects KW - Alkanesulfonic Acids -- blood KW - Alkanesulfonic Acids -- adverse effects KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/921143530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Perfluorinated+compounds+and+subfecundity+in+pregnant+women.&rft.au=Whitworth%2C+Kristina+W%3BHaug%2C+Line+S%3BBaird%2C+Donna+D%3BBecher%2C+Georg%3BHoppin%2C+Jane+A%3BSkjaerven%2C+Rolv%3BThomsen%2C+Cathrine%3BEggesbo%2C+Merete%3BTravlos%2C+Gregory%3BWilson%2C+Ralph%3BLongnecker%2C+Matthew+P&rft.aulast=Whitworth&rft.aufirst=Kristina&rft.date=2012-03-01&rft.volume=23&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=1531-5487&rft_id=info:doi/10.1097%2FEDE.0b013e31823b5031 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-25 N1 - Date created - 2012-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Toxicol. 2001 Mar-Apr;20(2):101-9 [11354466] Environ Sci Technol. 2010 Dec 15;44(24):9550-6 [21090747] Environ Sci Technol. 2002 Apr 1;36(7):146A-152A [11999053] Crit Rev Toxicol. 2004 Jul-Aug;34(4):351-84 [15328768] J Epidemiol Community Health. 1995 Jun;49(3):314-9 [7629471] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] Int J Epidemiol. 2006 Oct;35(5):1146-50 [16926217] Tohoku J Exp Med. 2007 May;212(1):63-70 [17464105] Environ Health Perspect. 2007 Sep;115(9):1298-305 [17805419] Toxicol Sci. 2007 Oct;99(2):366-94 [17519394] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Environ Health Perspect. 2007 Nov;115(11):1670-6 [18008002] Environ Health Perspect. 2007 Nov;115(11):1677-82 [18008003] Environ Sci Technol. 2008 Jul 1;42(13):4989-95 [18678038] J Chromatogr A. 2009 Jan 16;1216(3):385-93 [19026423] Int J Hyg Environ Health. 2009 May;212(3):239-70 [18565792] Hum Reprod. 2009 May;24(5):1200-5 [19176540] Environ Sci Technol. 2009 Mar 15;43(6):2131-6 [19368225] Reprod Toxicol. 2009 Jun;27(3-4):319-30 [19162172] Reprod Toxicol. 2009 Jun;27(3-4):212-30 [19429401] Environ Sci Technol. 2009 Apr 1;43(7):2641-7 [19452929] Epidemiology. 2010 Jan;21(1):160-1; author reply 161 [20010224] Environ Int. 2010 Aug;36(6):584-92 [20494442] Rev Environ Contam Toxicol. 2010;208:161-77 [20811864] Environ Sci Technol. 2010 Sep 15;44(18):7123-9 [20722423] Anal Bioanal Chem. 2010 Nov;398(6):2413-27 [20680618] Environ Int. 2011 Jan;37(1):178-83 [20880590] Comment In: Epidemiology. 2012 Mar;23(2):264-6 [22317809] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/EDE.0b013e31823b5031 ER - TY - JOUR T1 - A shell-based magnetic field model for magnetic proximity detection systems AN - 920792522; 16208866 AB - Several magnetic proximity detection systems have been developed for mining vehicles and mobile machinery to protect nearby workers. Magnetic field generators are often used in these systems to establish magnetic fields around the equipment. A sensor worn by a worker provides a measurement of the magnetic flux density that is used to estimate the proximity to the machine. The proximity detection systems currently available for underground mining equipment are capable of identifying whether a worker is near the machine. However, it is a challenge for these systems to accurately locate the worker. Mining machines, which have fast-moving, articulated parts, present hazards that change depending on the situation at hand as well as the specific location of the worker. In addition, the dynamic nature and confined spaces of the mining environment often demand that the workers be close to the machinery. Therefore, in many cases, simply knowing the proximity of a worker may be inadequate. To provide the most effective protection, it would be advantageous to know the worker's exact location relative to specific parts of the machine. To lay the foundation for measuring such a location, we have developed a shell-based model of the magnetic flux density distribution for a ferrite-cored generator. This paper will present an analysis of the model along with a model construction process. Also presented are the laboratory test results of a prototype system that implements this model to determine the exact location of a magnetic sensor using the fields from two generators. JF - Safety Science AU - Li, Jingcheng AU - Carr, Jacob AU - Jobes, Christopher AD - The National Institute for Occupational Safety and Health, 626 Cochran's Mill Road, Pittsburgh, PA 15236, USA, Jingcheng.Li@cdc.hhs.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 463 EP - 471 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 50 IS - 3 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Magnetic proximity detection system KW - Magnetic field generator KW - Shell-based magnetic flux density model KW - Warning zone KW - Stop zone KW - mining equipment KW - Sensors KW - Laboratory testing KW - Machinery KW - confined spaces KW - magnetic fields KW - Mining KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=A+shell-based+magnetic+field+model+for+magnetic+proximity+detection+systems&rft.au=Li%2C+Jingcheng%3BCarr%2C+Jacob%3BJobes%2C+Christopher&rft.aulast=Li&rft.aufirst=Jingcheng&rft.date=2012-03-01&rft.volume=50&rft.issue=3&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2011.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - mining equipment; Laboratory testing; Sensors; Machinery; confined spaces; magnetic fields; Mining; Construction industry DO - http://dx.doi.org/10.1016/j.ssci.2011.10.007 ER - TY - JOUR T1 - A CART technique to adjust production from longwall coal operations under ventilation constraints AN - 920792507; 16208863 AB - Methane emissions in longwall coal mines can arise from a variety of geologic and production factors, where ventilation and degasification are primary control measures to prevent excessive methane levels. However, poor ventilation practices or inadequate ventilation may result in accumulation of dangerous methane-air mixtures. The need exists for a set of rules and a model to be used as guidelines to adjust coal production according to expected methane emissions and current ventilation conditions. In this paper, hierarchical classification and regression tree (CART) analyses are performed as nonparametric modeling efforts to predict methane emissions that can arise during extraction of a longwall panel. These emissions are predicted for a range of coal productivities while considering specific operational, panel design and geologic parameters such as gas content, proximate composition of coal, seam height, panel width, cut height, cut depth, and panel size. Analyses are conducted for longwall mines with and without degasification of the longwall panel. These models define a range of coal productivities that can be achieved without exceeding specified emissions rates under given operating and geological conditions. Finally, the technique was applied to longwall mines that operate with and without degasification system to demonstrate its use and predictive capability. The predicted results proved to be close to the actual measurements to estimate ventilation requirements. Thus, the CART-based model that is given in this paper can be used to predict methane emission rates and to adjust operation parameters under ventilation constrains in longwall mining. JF - Safety Science AU - Karacan, COezgen AU - Goodman, Gerrit VR AD - National Institute of Occupational Safety and Health (NIOSH), Office of Mine Safety and Health Research (OMSHR), Dust Control, Ventilation, and Toxic Substances Branch, Pittsburgh, PA 15236, United States, cok6@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 510 EP - 522 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 50 IS - 3 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Mining safety KW - Coal mine methane KW - Methane emissions KW - Longwall mines KW - CART analyses KW - Methane KW - safety engineering KW - Ventilation KW - guidelines KW - Emissions KW - Emission measurements KW - Geology KW - Coal KW - Mines KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=A+CART+technique+to+adjust+production+from+longwall+coal+operations+under+ventilation+constraints&rft.au=Karacan%2C+COezgen%3BGoodman%2C+Gerrit+VR&rft.aulast=Karacan&rft.aufirst=COezgen&rft.date=2012-03-01&rft.volume=50&rft.issue=3&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2011.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Methane; safety engineering; Ventilation; guidelines; Emission measurements; Emissions; Geology; Coal; Mines DO - http://dx.doi.org/10.1016/j.ssci.2011.11.002 ER - TY - JOUR T1 - Heme iron from meat and risk of adenocarcinoma of the esophagus and stomach. AN - 916851426; 22044848 AB - Iron can cause oxidative stress and DNA damage, and heme iron can catalyze endogenous formation of N-nitroso compounds, which are potent carcinogens. Dietary iron promotes esophageal cancer incidence in animal studies and has been identified as a growth factor for Helicobacter pylori, an established risk factor for stomach cancer. We conducted a population-based case-control study of adenocarcinoma of the esophagus (n=124) and stomach (n=154) and 449 controls in Nebraska. Heme iron and total iron intake were estimated from a food frequency questionnaire and databases of heme and total iron. We used logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for known risk factors. Esophageal cancer was positively associated with higher intakes of heme iron (ORQ4 vs. Q1=3.04, 95% CI: 1.20-7.72; P trend=0.009) and total iron from meat sources (ORQ4 vs. Q1=2.67, 95% CI: 0.99-7.16; P trend=0.050). Risk of stomach cancer was elevated among those with higher intakes of heme iron (ORQ4 vs.Q1=1.99, 95% CI: 1.00-3.95; P trend=0.17) and total iron from meat (OR=2.26, 95% CI: 1.14-4.46; P trend=0.11). Iron intake from all dietary sources was not significantly associated with risk of either cancer. Our results suggest that high intakes of heme and iron from meat may be important dietary risk factors for esophageal and stomach cancer and may partly explain associations with red meat. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Ward, Mary H AU - Cross, Amanda J AU - Abnet, Christian C AU - Sinha, Rashmi AU - Markin, Rodney S AU - Weisenburger, Dennis D AD - Department of Health and Human Services, Occupational and Environmental Epidemiology Branch , National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. wardm@mail.nih.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 134 EP - 138 VL - 21 IS - 2 KW - Iron, Dietary KW - 0 KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Young Adult KW - Eating -- physiology KW - Feeding Behavior -- physiology KW - Humans KW - Aged KW - Nutrition Surveys KW - Heme -- adverse effects KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Heme -- analysis KW - Female KW - Male KW - Adenocarcinoma -- epidemiology KW - Meat -- adverse effects KW - Iron, Dietary -- analysis KW - Adenocarcinoma -- etiology KW - Iron, Dietary -- adverse effects KW - Meat -- analysis KW - Stomach Neoplasms -- epidemiology KW - Stomach Neoplasms -- etiology KW - Esophageal Neoplasms -- etiology KW - Iron, Dietary -- administration & dosage KW - Esophageal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916851426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Heme+iron+from+meat+and+risk+of+adenocarcinoma+of+the+esophagus+and+stomach.&rft.au=Ward%2C+Mary+H%3BCross%2C+Amanda+J%3BAbnet%2C+Christian+C%3BSinha%2C+Rashmi%3BMarkin%2C+Rodney+S%3BWeisenburger%2C+Dennis+D&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2012-03-01&rft.volume=21&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=1473-5709&rft_id=info:doi/10.1097%2FCEJ.0b013e32834c9b6c LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-07 N1 - Date created - 2012-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2001 Aug;22(8):1119-29 [11470739] Nutr Cancer. 2002;42(1):33-40 [12235648] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 1985 Jul;122(1):13-26 [4014190] Epidemiology. 1990 Sep;1(5):349-56 [2078610] Epidemiology. 1990 Jan;1(1):58-64 [2081241] Cancer Epidemiol Biomarkers Prev. 1993 Jul-Aug;2(4):305-12 [8348053] Int J Cancer. 1995 Jan 17;60(2):160-2 [7829208] Alcohol. 1995 Mar-Apr;12(2):97-104 [7772272] Cancer Lett. 1995 Jun 29;93(1):17-48 [7600541] Int J Cancer. 1996 Mar 28;66(1):130-4 [8608956] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] J Gastroenterol Hepatol. 1999 Mar;14(3):202-14 [10197487] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Int J Cancer. 2005 Nov 20;117(4):643-7 [15929082] Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Am J Gastroenterol. 2011 Mar;106(3):432-42 [20978481] Cancer Causes Control. 2010 Dec;21(12):2269-79 [20936528] Int J Occup Environ Health. 2008 Jul-Sep;14(3):193-7 [18686719] Carcinogenesis. 2007 Mar;28(3):685-90 [17052997] World J Gastroenterol. 2006 Jul 21;12(27):4296-303 [16865769] Carcinogenesis. 2006 Jul;27(7):1497-501 [16571648] J Natl Cancer Inst. 2006 Mar 1;98(5):345-54 [16507831] Eur J Gastroenterol Hepatol. 2000 Dec;12(12):1263-5 [11192313] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/CEJ.0b013e32834c9b6c ER - TY - JOUR T1 - Survey of polycyclic aromatic hydrocarbons in marine products in Korea using GC/MS AN - 1660418909; 17588501 AB - This study investigates polycyclic aromatic hydrocarbons (PAHs) in marine products on the Korean market. A total of 280 samples of fish (n = 100), shellfish (n = 80), cephalopod (n = 60) and crustacea (n = 40) were collected for analyses of PAHs (naphthalene, acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, indeno[1,2,3-c,d]pyrene, dibenz[a,h]anthracene and benzo[g,h,i]perylene). The analytical procedure was based on the matrix solid-phase dispersion on Florisil cartridges and extraction with hexane/dichloromethane (3:1, v/v). The PAHs were determined by gas chromatography with mass spectrometric detection using selective ion monitoring. Average recoveries for all the PAHs studied were in the range 58-79%. The sum of 16 PAHs concentrations in fish, shellfish, cephalopod/crustacea were in the range 0.2-0.5, 1.2-1.6 and 0.8-1.9 mu g/kg, respectively. JF - Food Additives & Contaminants: Part B - Surveillance Communications AU - Hwang, Kyungmi AU - Woo, Sungmin AU - Choi, Jangduck AU - Kim, Meehye AD - Imported Food Analysis Division, Korea Food and Drug Administration, 120 Juan-1-dong, Nam-gu, Incheon 402-835, South Korea, meehkim@korea.kr Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 1 EP - 7 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 5 IS - 1 SN - 1939-3210, 1939-3210 KW - Toxicology Abstracts KW - PAH KW - fish and fish products KW - Fluoranthene KW - Anthracene KW - acenaphthene KW - fluorene KW - Polycyclic aromatic hydrocarbons KW - Crustacea KW - Naphthalene KW - Pyrene KW - Food contamination KW - Chrysene KW - Food additives KW - Phenanthrene KW - Dichloromethane KW - Gas chromatography KW - Benzo(a)pyrene KW - n-Hexane KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660418909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+of+polycyclic+aromatic+hydrocarbons+in+marine+products+in+Korea+using+GC%2FMS&rft.au=Hwang%2C+Kyungmi%3BWoo%2C+Sungmin%3BChoi%2C+Jangduck%3BKim%2C+Meehye&rft.aulast=Hwang&rft.aufirst=Kyungmi&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Anthracene; Fluoranthene; Polycyclic aromatic hydrocarbons; fluorene; acenaphthene; Naphthalene; Pyrene; Food contamination; Chrysene; Phenanthrene; Food additives; Dichloromethane; Gas chromatography; Benzo(a)pyrene; n-Hexane; Crustacea DO - http://dx.doi.org/10.1080/19393210.2011.611897 ER - TY - JOUR T1 - Shift work and the incidence of injury among police officers AN - 1560138167; 19416352 AB - Background Police officers may be injury prone due to fatigue, erratic work hours, and insufficient sleep. This study explored injury incidence among police officers across shifts. Methods Day-to-day shift data from computerized payroll records (1994-2010) were available from a mid-sized urban police department (n=430). Sleep duration, shift activity level, returning to work after days off, and injury incidence over time were also examined. Results Age-adjusted incidence rate ratio (IRR) for injury on the midnight shift was 72% larger than the day shift (IRR=1.72; 95% CI=1.26-2.36) and 66% larger than the afternoon shift (IRR=1.66; 95% CI=1.23-2.25). Injury incidence for the first day back on the midnight shift was 69% larger than day shift (IRR=1.69; 95% CI=1.23-2.32) and 54% larger than the afternoon shift (IRR=1.54; 95% CI=1.36-1.76). High activity level combined with midnight shift work put officers at increased injury risk (IRR=2.31; P=0.0003). Probability of remaining free of injury was significantly higher for day shift than midnight shift (P<0.0001). Conclusions Higher injury risk was associated with night shift work in police officers. Night shift combined with high work activity was strongly associated with injury risk. There was a significantly higher probability of not being injured on day compared to midnight or afternoon shifts. Am. J. Ind. Med. 55:217-227, 2012. copyright 2011 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Violanti, John M AU - Fekedulegn, Desta AU - Andrew, Michael E AU - Charles, Luenda E AU - Hartley, Tara A AU - Vila, Bryan AU - Burchfiel, Cecil M AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia., violanti@buffalo.edu Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 217 EP - 227 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 55 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - police KW - occupational injury KW - shift work KW - work hours KW - fatigue KW - sleep KW - activity levels KW - Health risks KW - Shift work KW - Fatigue KW - Injuries KW - Police KW - Working conditions KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560138167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Shift+work+and+the+incidence+of+injury+among+police+officers&rft.au=Violanti%2C+John+M%3BFekedulegn%2C+Desta%3BAndrew%2C+Michael+E%3BCharles%2C+Luenda+E%3BHartley%2C+Tara+A%3BVila%2C+Bryan%3BBurchfiel%2C+Cecil+M&rft.aulast=Violanti&rft.aufirst=John&rft.date=2012-03-01&rft.volume=55&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Shift work; Health risks; Fatigue; Injuries; Police; Working conditions DO - http://dx.doi.org/10.1002/ajim.22007 ER - TY - JOUR T1 - Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment AN - 1443366850; 18507726 AB - Context. Healthcare worker exposure to antineoplastic drugs continues to be reported despite safe handling guidelines published by several groups. Sensitive sampling and analytical methods are needed so that occupational safety and health professionals may accurately assess environmental and biological exposure to these drugs in the workplace.Objective. To develop liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analytical methods for measuring five antineoplastic drugs in samples from the work environment, and to apply these methods in validating sampling methodology. A single method for quantifying several widely used agents would decrease the number of samples required for method development, lower cost, and time of analysis. Methods for measuring these drugs in workers' urine would also be useful in monitoring personal exposure levels.Results. LC-MS/MS methods were developed for individual analysis of five antineoplastic drugs in wipe and air sample media projected for use in field sampling: cyclophosphamide, ifosfamide, paclitaxel, doxorubicin, and 5-fluorouracil. Cyclophosphamide, ifosfamide, and paclitaxel were also measured simultaneously in some stages of the work. Extraction methods for air and wipe samples were developed and tested using the aforementioned analytical methods. Good recoveries from the candidate air and wipe sample media for most of the compounds, and variable recoveries for test wipe samples depending on the surface under study, were observed. Alternate LC-MS/MS methods were also developed to detect cyclophosphamide and paclitaxel in urine samples.Conclusions. The sampling and analytical methods were suitable for determining worker exposure to antineoplastics via surface and breathing zone contamination in projected surveys of healthcare settings. JF - Journal of Oncology Pharmacy Practice AU - Pretty, Jack R AU - Connor, Thomas H AU - Spasojevic, Ivan AU - Kurtz, Kristine S AU - McLaurin, Jeffrey L AU - B'Hymer, Clayton AU - Debord, D Gayle AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Cincinnati, OH, USA  , jrp0@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 23 EP - 36 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 18 IS - 1 SN - 1078-1552, 1078-1552 KW - Health & Safety Science Abstracts KW - Health care KW - Urine KW - Guidelines KW - Air sampling KW - Antineoplastic drugs KW - Drugs KW - Occupational exposure KW - Medical personnel KW - Spectrometry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443366850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Oncology+Pharmacy+Practice&rft.atitle=Sampling+and+mass+spectrometric+analytical+methods+for+five+antineoplastic+drugs+in+the+healthcare+environment&rft.au=Pretty%2C+Jack+R%3BConnor%2C+Thomas+H%3BSpasojevic%2C+Ivan%3BKurtz%2C+Kristine+S%3BMcLaurin%2C+Jeffrey+L%3BB%27Hymer%2C+Clayton%3BDebord%2C+D+Gayle&rft.aulast=Pretty&rft.aufirst=Jack&rft.date=2012-03-01&rft.volume=18&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Oncology+Pharmacy+Practice&rft.issn=10781552&rft_id=info:doi/10.1177%2F1078155210389215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Number of references - 28 N1 - Last updated - 2013-10-21 N1 - SubjectsTermNotLitGenreText - Health care; Urine; Guidelines; Air sampling; Antineoplastic drugs; Drugs; Medical personnel; Occupational exposure; Spectrometry DO - http://dx.doi.org/10.1177/1078155210389215 ER - TY - JOUR T1 - Caribbean ciguatoxin profile in raw and cooked fish implicated in ciguatera AN - 1356926996; 15910319 AB - A cooked meal remnant and uncooked portion of a Caribbean barracuda suspected in ciguatera fish poisoning were examined for the presence of ciguatoxins (CTX). Samples were analysed using a tiered method of CTX analysis consisting of in vitro cell (N2a) assay to assess composite toxicity and liquid chromatography-tandem mass spectrometry (LC-MS/MS) for structural confirmation. Meal remnant and uncooked fish extracts were cytotoxic by N2a cell assay and Caribbean ciguatoxin congener C-CTX-1 was structurally confirmed. Sample extracts were fractionated by LC and fractions analysed by the cell assay. The cytotoxicity profiles of cooked meal remnant and uncooked fish were similar. Cytotoxicity-guided LC-MS/MS analyses identified several CTX congeners contributing to the composite toxicity of the samples. C-CTX-1 was a major contributor, supporting its utility as a biomarker of Caribbean ciguatoxic fish. JF - Food Chemistry AU - Abraham, Ann AU - Jester, Edward LE AU - Granade, Hudson R AU - Plakas, Steven M AU - Dickey, Robert W AD - FDA, Division of Seafood Science & Technology, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528-0158, USA, ann.abraham@fda.hhs.gov Y1 - 2012/03/01/ PY - 2012 DA - 2012 Mar 01 SP - 192 EP - 198 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 131 IS - 1 SN - 0308-8146, 0308-8146 KW - ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Ciguatoxins KW - Ciguatera fish poisoning KW - Toxin profile KW - Caribbean KW - Poisoning KW - Toxicity KW - Biomarkers KW - biomarkers KW - Mass spectroscopy KW - Ciguatera KW - Cytotoxicity KW - ASW, Caribbean Sea KW - Fish poisoning KW - Congeners KW - Ciguatoxin KW - X 24320:Food Additives & Contaminants KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356926996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Caribbean+ciguatoxin+profile+in+raw+and+cooked+fish+implicated+in+ciguatera&rft.au=Abraham%2C+Ann%3BJester%2C+Edward+LE%3BGranade%2C+Hudson+R%3BPlakas%2C+Steven+M%3BDickey%2C+Robert+W&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2012-03-01&rft.volume=131&rft.issue=1&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2011.08.059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Fish poisoning; Biomarkers; Toxicity; Ciguatoxin; Ciguatera; Poisoning; Congeners; biomarkers; Mass spectroscopy; ASW, Caribbean Sea DO - http://dx.doi.org/10.1016/j.foodchem.2011.08.059 ER - TY - JOUR T1 - ACCIDENTS IN FIXED-WING AIRCRAFT DURING INSTRUCTIONAL FLIGHTS AN - 1348488118; 17906644 AB - INTRODUCTION: Flight training is generally considered one of the safest categories of general aviation; however no type of flying is without risk. The purpose of this study was to identify risk factors for accidents involving flight instruction in fixed-wing aircraft. METHODS: National Transportation Safety Board accident data were used to identify accidents that occurred during instructional flights in fixed-wing aircraft during 1999-2010. Instructional flights were a part of flight training, those that required instructor supervision or presence onboard. Narrative reports were reviewed to determine primary or secondary student status and whether a flight instructor was present. Data were then analyzed to determine phase of flight, location, circumstances and causes. RESULTS: During 1999-2010, 2488 instructional flights were involved in 2474 accidents during civilian flight training operations, resulting in 491 fatalities and 290 serious injuries. The majority of these instructional flights involved primary students (67%, 1673) and over half (55%, 1370) occurred with a certificated flight instructor in the airplane. The most frequent occurrences were loss of control on ground or water (24%), loss of control in flight (15%), hard landing (15%) and loss of engine power (13%). One hundred accidents resulted from fuel starvation or exhaustion; 65 of these accidents had instructors in the aircraft. Instructor's inaction or improper action was identified by the NTSB as a primary factor in almost half (48%, 659) of the accident flights with an instructor onboard. A majority of the accidents occurred on an airstrip (68%); the most common phases of flight in which accidents took place were landing (34%, 857) and takeoff (12%, 297). DISCUSSION: These data indicate a need for increased attentiveness and improved supervision of students by flight instructors. Instructor proficiency in emergency procedures and maneuvers and setting conservative criteria for safe flight operations, including fuel reserves, winds and altitudes may prevent future accidents. Capable instructors may prevent accidents during dual flight and by imparting the skills, knowledge and judgment for safe solo flight by students. JF - Aviation, Space, and Environmental Medicine AU - O'Connor, M B AU - Mode, N A AU - Lincoln, J M AD - APRO, CDC/NIOSH, Anchorage, AK Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 338 EP - 339 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 83 IS - 3 SN - 0095-6562, 0095-6562 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Accidents KW - Altitude KW - Transportation KW - Aircraft KW - Training KW - Fuels KW - Reviews KW - Risk factors KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1348488118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluating+the+Sensitivity+of+Library-Based+Spectral+Correlation+Methods+and+Their+Transferability+Between+Different+Spectrometers&rft.au=Rodriguez%2C+Jason%3BBuhse%2C+Lucinda%3BWestenberger%2C+Benjamin%3BKauffman%2C+John&rft.aulast=Rodriguez&rft.aufirst=Jason&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; Altitude; Accidents; Transportation; Aircraft; Training; Risk factors; Reviews; Fuels ER - TY - JOUR T1 - From The Office Of The National Coordinator: The Strategy For Advancing The Exchange Of Health Information AN - 1266147720; 201300325 AB - Electronic health information exchange addresses a critical need in the US health care system to have information follow patients to support patient care. Today little information is shared electronically, leaving doctors without the information they need to provide the best care. With payment reforms providing a strong business driver, the demand for health information exchange is poised to grow. The Office of the National Coordinator for Health Information Technology, Department of Health and Human Services, has led the process of establishing the essential building blocks that will support health information exchange. Over the coming year, this office will develop additional policies and standards that will make information exchange easier and cheaper and facilitate its use on a broader scale. Adapted from the source document. JF - Health Affairs AU - Williams, Claudia AU - Mostashari, Farzad AU - Mertz, Kory AU - Hogin, Emily AU - Atwal, Parmeeth AD - State Health Information Exchange Program, Health Information Technology (ONC), Department of Health and Human Services, in Washington, D.C claudia.williams@hhs.gov Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 527 EP - 536 PB - Project HOPE, Bethesda MD VL - 31 IS - 3 SN - 0278-2715, 0278-2715 KW - Human Services KW - Information Technology KW - United States of America KW - Physicians KW - Patients KW - Health KW - Reform KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266147720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=From+The+Office+Of+The+National+Coordinator%3A+The+Strategy+For+Advancing+The+Exchange+Of+Health+Information&rft.au=Williams%2C+Claudia%3BMostashari%2C+Farzad%3BMertz%2C+Kory%3BHogin%2C+Emily%3BAtwal%2C+Parmeeth&rft.aulast=Williams&rft.aufirst=Claudia&rft.date=2012-03-01&rft.volume=31&rft.issue=3&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.1314 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-01-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care Services; Health; Patients; Human Services; Reform; Physicians; United States of America; Information Technology DO - http://dx.doi.org/10.1377/hlthaff.2011.1314 ER - TY - BOOK T1 - World Trade Center Chemicals of Potential Concern and Selected Other Chemical Agents: Summary of Cancer Classifications by the National Toxicology Program and International Agency for Research on Cancer AN - 1151044182; 2011-314259 AB - The National Institute for Occupational Safety and Health (NIOSH) presented the first periodic review of cancer for the WTC Health Program in July 2011. This review included findings from the peer-reviewed scientific and medical literature about exposures and cancer resulting from the September 11, 2001, terrorist attacks [NIOSH 2011]. The Exposure section of the first periodic review provided an initial list of agents detected in the area around the World Trade Center (WTC) during the disaster response and recovery periods. Tables, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Mar 2012, 60 pp. AU - World Trade Center Health Program Cancer Working Group Y1 - 2012/03// PY - 2012 DA - March 2012 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Occupational health and safety KW - Health conditions and policy - Diseases and disorders KW - Education and education policy - Statistics, research, research methods, and research support KW - International relations - International relief and humanitarian assistance KW - Administration of justice - Crime and criminals KW - International relations - International relations KW - Disaster relief KW - Chemicals KW - World trade center KW - Classification KW - United States Occupational safety and health administration KW - International agencies KW - Cancer KW - Industrial safety KW - Terrorists KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1151044182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=World+Trade+Center+Health+Program+Cancer+Working+Group&rft.aulast=World+Trade+Center+Health+Program+Cancer+Working+Group&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.title=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2012-115/pdfs/2012-115.pdf LA - English DB - PAIS Index N1 - Date revised - 2012-11-01 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2012 N1 - SuppNotes - NIOSH Publication Number 2012-115 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Ergonomics in design: interventions for youth working in the agricultural industry AN - 1038600407; 17034110 AB - Youth and adolescents make up a substantial segment of the working population in the agricultural industry and many of these young workers are required to perform physically demanding jobs that put them at significant risk for developing work-related musculoskeletal disorders (MSDs). Although there are no surveillance systems in place to track these potential injuries for youth who work in agriculture, based on our understanding of the magnitude of risk for these tasks, a number of interventions have been developed and evaluated that should reduce the risk of MSDs for youth who perform these high risk tasks. The purpose of this article is to raise the research community's awareness to the risk of work-related MSDs for youth who work in agriculture and to demonstrate that ergonomic designers are best suited to develop cost-effective interventions for use in these tasks that can be easily implemented. JF - Theoretical Issues in Ergonomics Science AU - Waters, Thomas R AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 270 EP - 285 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 2 SN - 1463-922X, 1463-922X KW - Risk Abstracts; Health & Safety Science Abstracts KW - youth KW - farms KW - lifting KW - musculoskeletal disorders KW - Agriculture KW - Economics KW - Intervention KW - Risk reduction KW - Ergonomics KW - Working conditions KW - Adolescents KW - Design KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038600407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=The+Role+of+Quality+by+Design+in+Process+Analytical+Technology+%28PAT%29+and+Real+Time+Release+Testing+%28RTRT%29+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Agriculture; Economics; Intervention; Risk reduction; Adolescents; Working conditions; Ergonomics; Occupational health; Design DO - http://dx.doi.org/10.1080/1463922X.2010.497196 ER - TY - JOUR T1 - Post-Hire Asthma Among Insect-Rearing Workers AN - 1020856796; 16507823 AB - Objective: To evaluate the incidence of post-hire asthma (PHA) among insect-rearing workers, defined as asthma, the symptoms of which appeared after hire at the current workplace. Methods: We surveyed the health of workers at three insect-rearing facilities and an associated office facility. We calculated the incidence and estimated hazard ratios for PHA. Results: Post-hire asthma incidence in 157 insect-rearing workers was 16.2 per 1000 person-years compared with 9.2 per 1,000 person-years in 70 office workers. Workers with predominant exposure to Lepidoptera had an incidence of 26.9 per 1000 person-years and a hazard ratio of 5.5 (95% confidence interval: 1.6 to 23.9) adjusted for sex, race, and parental asthma. In contrast, the presence of specific immunoglobulin E to Lepidoptera antigens was not associated with PHA. Conclusion: Insect-rearing workers had a high incidence of PHA, primarily accounted for by workplace exposure to Lepidoptera. JF - Journal of Occupational and Environmental Medicine AU - Suarthana, E AU - Shen, A AU - Henneberger, P K AU - Kreiss, K AU - Leppla, N C AU - Bueller, D AU - Lewis, D M AU - Bledsoe, T A AU - Janotka, E AU - Petsonk, EL AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown WV 26505, USA, elp2@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 310 EP - 317 VL - 54 IS - 3 SN - 1076-2752, 1076-2752 KW - Entomology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Workers KW - Immunoglobulin E KW - Asthma KW - Respiratory diseases KW - Occupational exposure KW - Lepidoptera KW - Z 05300:General KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020856796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Post-Hire+Asthma+Among+Insect-Rearing+Workers&rft.au=Suarthana%2C+E%3BShen%2C+A%3BHenneberger%2C+P+K%3BKreiss%2C+K%3BLeppla%2C+N+C%3BBueller%2C+D%3BLewis%2C+D+M%3BBledsoe%2C+T+A%3BJanotka%2C+E%3BPetsonk%2C+EL&rft.aulast=Suarthana&rft.aufirst=E&rft.date=2012-03-01&rft.volume=54&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823fe098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Workers; Immunoglobulin E; Asthma; Occupational exposure; Respiratory diseases; Lepidoptera DO - http://dx.doi.org/10.1097/JOM.0b013e31823fe098 ER - TY - JOUR T1 - Disaster Preparedness of Linguistically Isolated Populations: Practical Issues for Planners AN - 1018384488; 201207888 AB - In the absence of culturally and linguistically appropriate disaster preparedness plans, several linguistically isolated and culturally diverse population groups are disproportionately disadvantaged in the United States. The communication gap poses challenges to emergency preparedness planners and response personnel in predisaster communication and postdisaster response efforts. Houston Department of Health and Human Services aimed to develop practical recommendations for local emergency response personnel so as to improve dissemination of emergency information and equitable delivery of services to linguistically isolated communities in the greater Houston area. Sixteen focus group discussions were conducted among linguistically isolated immigrant populations living in the greater Houston metropolitan area who primarily spoke one of the Spanish, Chinese, Vietnamese, and Somali languages. Our questions focused on general knowledge and understanding of disasters and explored experiences during Houston's most recent disaster, Hurricane Ike. We found that (a) understanding of disaster and preparedness is contextual, (b) awareness of preparedness needs and actual plans among LIPs is inadequate, and (c) word of mouth is the preferred information source for linguistically isolated groups. Disaster preparedness plans of a given jurisdiction should reflect the culturally and linguistically appropriate components addressing the needs, concerns, context-based knowledge or awareness, and perceptions of linguistically isolated populations. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Promotion Practice AU - Nepal, Vishnu AU - Banerjee, Deborah AU - Perry, Mark AU - Scott, Deborah AD - Houston Department of Health and Human Services, Texas Y1 - 2012/03// PY - 2012 DA - March 2012 SP - 265 EP - 271 VL - 13 IS - 2 SN - 1524-8399, 1524-8399 KW - Texas (88950) KW - Communication (13600) KW - Language Policy (43450) KW - United States of America (92750) KW - Minority Groups (54240) KW - Military Language (54050) KW - Immigrants (34670) KW - article KW - 5611: sociolinguistics; language planning/policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018384488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Disaster+Preparedness+of+Linguistically+Isolated+Populations%3A+Practical+Issues+for+Planners&rft.au=Nepal%2C+Vishnu%3BBanerjee%2C+Deborah%3BPerry%2C+Mark%3BScott%2C+Deborah&rft.aulast=Nepal&rft.aufirst=Vishnu&rft.date=2012-03-01&rft.volume=13&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Military Language (54050); Communication (13600); Minority Groups (54240); Immigrants (34670); United States of America (92750); Texas (88950); Language Policy (43450) ER - TY - JOUR T1 - Occupational Safety and Health in the USA: Now and the Future AN - 1014105073; 16644574 AB - In the USA, national worker protection legislation was enacted in 1970. The legislation required that research, recommendations and guidance be developed to aid employers and workers, that workplace health and safety standards be adopted, that employer comply with those rules and that the government police employer compliance, and that assistance be offered to employers and workers to help them maintain a safe and healthful workplace. In the 40 yr since passage of the Occupational Safety and Health Act of 1970, worker injury, illness and fatalities have declined but not been eliminated. Efforts to accelerate the standards adoption process are much discussed in the USA along with how to protect workers from emerging hazards like nanotechnology. New strategies which seek to eliminate not only the causes of work-related injury and illness, but also more broadly, worker injury and illness, are on the horizon. JF - Industrial Health AU - Howard, J AU - Hearl, F AD - National Institute for Occupational Safety and Health, Conters for Disease Control and Prevention, U.S. Department of Health and Human Services, 395 E Street, S.W., Suite 9200, Washington DC, USA, zkz1@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 80 EP - 83 VL - 50 IS - 2 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - USA KW - Injuries KW - police KW - Occupational safety KW - Compliance KW - Police KW - Legislation KW - nanotechnology KW - Nanotechnology KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014105073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Occupational+Safety+and+Health+in+the+USA%3A+Now+and+the+Future&rft.au=Howard%2C+J%3BHearl%2C+F&rft.aulast=Howard&rft.aufirst=J&rft.date=2012-03-01&rft.volume=50&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Mortality; police; Injuries; Compliance; Occupational safety; Police; Legislation; Nanotechnology; nanotechnology; USA ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF KAVA KAVA EXTRACT (CAS No. 9000-38-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 1011479278; 22441424 AB - Kava kava products are extracts from the root of the tropical shrub Piper methysticum. It was originally used for ceremonial beverages in the South Pacific and currently is used as an herbal product as an alternative to anti-anxiety drugs. We studied the effects of kava kava extract on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing kava kava extract in corn oil through a tube directly into the stomachs of 50 male and female rats and mice per dose group 5 days per week for 2 years. Exposed rats received either 0.1, 0.3 or 1 gram of kava kava extract per kilogram of body weight and mice received 0.25, 0.5, or 1 g/kg. Control animals received corn oil with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. There was a notable increase in uncommon malignant liver cancers (hepatoblastomas) in male mice and in hepatocellular carcinomas in female mice. In male rats receiving kava kava extract there was a slight increase in common testicular tumors. Other non-cancerous lesions that occurred in exposed animals were hepatocyte hypertrophy of the liver in male and female rats and mice and forestomach inflammation in male and female rats and female mice. We conclude that kava kava extract caused cancers of the liver in male and female mice. Increased incidences of testicular tumors in male rats might have been related to kava kava exposure. Kava kava also caused increased incidences of lesions in the liver, forestomach, kidney, eye, and pancreas of male and female rats, in the liver of male and female mice, and in the forestomach of female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 1 EP - 186 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Plant Extracts KW - gamma-Glutamyltransferase KW - Beverages KW - Herbal medicine KW - Liver cancer KW - Toxicology KW - Animals KW - Liver -- enzymology KW - Liver -- pathology KW - Dose-Response Relationship, Drug KW - Humans KW - gamma-Glutamyltransferase -- metabolism KW - Mice KW - Rats KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Liver -- drug effects KW - Neoplasms, Experimental -- chemically induced KW - Carcinogenicity Tests KW - Female KW - Male KW - Organ Size -- drug effects KW - Plant Extracts -- toxicity KW - Kava -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+KAVA+KAVA+EXTRACT+%28CAS+No.+9000-38-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=571&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Document feature - Illustrations; References; Tables; Diagrams N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1011479276 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=571&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1011479275 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011479275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BAndrews%2C+Ronnee+N%3BKashon%2C+Michael+L%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2012-01-27&rft.volume=&rft.issue=&rft.spage=73&rft.isbn=&rft.btitle=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.title=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.10.021 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Mar 2012 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - A Consensus Method for Updating Psychosocial Measures Used in NIOSH Health Hazard Evaluations AN - 1008846064; 16507828 AB - Objective: An expert panel was convened to select practical, valid psychosocial measures for use during National Institute for Occupational Safety and Health field investigations. Methods: A taxonomy of psychosocial constructs was developed using existing taxonomies and criteria regarding the malleability, actionability, and validity of constructs. Panel members identified measures for each construct based on their expertise and experience. Measures were selected on the basis of the following criteria: practicality, brevity, validity, availability of existing data, and lack of confounds between psychosocial constructs and outcomes. Results: The panel came to a consensus in recommending 24 measures representing 22 constructs. Conclusions: It is important that the National Institute for Occupational Safety and Health regularly evaluates its methodologies to ensure it is in line with current best practices. The measures identified will be used modularly in the National Institute for Occupational Safety and Health fieldwork depending on the nature of the evaluation request, industry type, and worker population. JF - Journal of Occupational and Environmental Medicine AU - Wiegand, D M AU - Chen, P Y AU - Hurrell, JJ Jr AU - Jex, S AU - Nakata, A AU - Nigam, JA AU - Robertson, M AU - Tetrick, LE AD - NIOSH/DSHEFS/HETAB, 4676 Columbia Parkway (MS R-10), Cincinnati, OH 45226, USA, dwiegand@cdc.gov Y1 - 2012/03// PY - 2012 DA - Mar 2012 SP - 350 EP - 355 VL - 54 IS - 3 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Hazards KW - best practices KW - Fieldwork KW - Best practices KW - Occupational safety KW - Taxonomy KW - taxonomy KW - fieldwork KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1008846064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Cytokines+and+Inflammation+Conference&rft.atitle=Expression+Profiles+of+Human+Interferon-alpha+and+Interferon-lambda+Subtypes+Are+Ligand-+and+Cell-+Dependent&rft.au=Rabin%2C+Ronald&rft.aulast=Rabin&rft.aufirst=Ronald&rft.date=2012-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Hazards; best practices; Fieldwork; Best practices; Occupational safety; Taxonomy; fieldwork; taxonomy DO - http://dx.doi.org/10.1097/JOM.0b013e3182440a04 ER - TY - JOUR T1 - An analysis of reservoir conditions and responses in longwall panel overburden during mining and its effect on gob gas well performance AN - 1520102583; 2014-027609 AB - NIOSH conducted a cooperative research study to provide direct measurements of changing reservoir conditions in longwall panel overburden. The field measurements documented changes in permeabilities, methane concentrations, fluid pressures, and the effects of adjacent gob gas ventholes (GGVs) on NIOSH boreholes drilled in the study panel. Three different stratigraphic horizons were monitored by the NIOSH boreholes. Results indicated that the gob gas venthole fracture network formed 24 to 46m (80 to 150ft) ahead of the mining face. Overburden permeabilities within the same overburden test zones were approximately 1md prior to undermining, increasing to hundreds or thousands of md during undermining. Permeabilities measured seven months after undermining showed additional increases. The relationship between changing reservoir conditions, longwall face position, and surface movement is discussed. Recommendations are made to optimize GGV performance by evaluating changes in subsidence produced by mining, resulting in rock stresses that substantially influence induced fracture permeability. Mechanisms to account for the observed changes in reservoir conditions are reported. Abstract Copyright (2012) Elsevier, B.V. JF - Engineering Geology AU - Schatzel, Steven J AU - Karacan, C Ozgen AU - Dougherty, Heather AU - Goodman, Gerrit V R Y1 - 2012/02/24/ PY - 2012 DA - 2012 Feb 24 SP - 65 EP - 74 PB - Elsevier, Amsterdam VL - 127 SN - 0013-7952, 0013-7952 KW - mining KW - overburden KW - monitoring KW - methane KW - underground mining KW - explosions KW - aliphatic hydrocarbons KW - subsidence KW - alkanes KW - reservoir rocks KW - gases KW - ventilation KW - water pressure KW - organic compounds KW - longwall mining KW - hydraulic head KW - boreholes KW - fluid pressure KW - hydrocarbons KW - reservoir properties KW - vents KW - permeability KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520102583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Engineering+Geology&rft.atitle=An+analysis+of+reservoir+conditions+and+responses+in+longwall+panel+overburden+during+mining+and+its+effect+on+gob+gas+well+performance&rft.au=Schatzel%2C+Steven+J%3BKaracan%2C+C+Ozgen%3BDougherty%2C+Heather%3BGoodman%2C+Gerrit+V+R&rft.aulast=Schatzel&rft.aufirst=Steven&rft.date=2012-02-24&rft.volume=127&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Engineering+Geology&rft.issn=00137952&rft_id=info:doi/10.1016%2Fj.enggeo.2012.01.002 L2 - http://www.sciencedirect.com/science/journal/00137952 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2014-01-01 N1 - Number of references - 25 N1 - Document feature - illus. N1 - Last updated - 2014-05-01 N1 - CODEN - EGGOAO N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; boreholes; explosions; fluid pressure; gases; hydraulic head; hydrocarbons; longwall mining; methane; mining; monitoring; organic compounds; overburden; permeability; reservoir properties; reservoir rocks; subsidence; underground mining; ventilation; vents; water pressure DO - http://dx.doi.org/10.1016/j.enggeo.2012.01.002 ER - TY - CPAPER T1 - Facilitating Data Sharing to Enhance Drug Effectiveness and Safety T2 - 2012 Keystone Symposia Meeting on Complex Traits: Genomics and Computational Approaches AN - 1326135401; 6207544 JF - 2012 Keystone Symposia Meeting on Complex Traits: Genomics and Computational Approaches AU - Seyfert-Margolis, Vicki Y1 - 2012/02/20/ PY - 2012 DA - 2012 Feb 20 KW - Drugs KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.atitle=Facilitating+Data+Sharing+to+Enhance+Drug+Effectiveness+and+Safety&rft.au=Seyfert-Margolis%2C+Vicki&rft.aulast=Seyfert-Margolis&rft.aufirst=Vicki&rft.date=2012-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/index.cfm?e=Web.Meeting.Program&MeetingID=1153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - JOUR T1 - Genotoxicity of furan in Big Blue rats. AN - 918033529; 22200623 AB - Furan is a multispecies liver carcinogen whose cancer mode of action (MOA) is unclear. A major metabolite of furan is a direct acting mutagen; however, it is not known if genotoxicity is a key step in the tumors that result from exposure to furan. In order to address this question, transgenic Big Blue rats were treated by gavage five times a week for 8 weeks with two concentrations of furan used in cancer bioassays (2 and 8mg/kg), and with two higher concentrations (16 and 30mg/kg). Peripheral blood samples taken 24h after the 5th dose (1 week of dosing) were used to assay for micronucleus (MN) frequency in normochromatic erythrocytes (NCEs) and reticulocytes (RETs), and Pig-a gene mutation in total red blood cells (RBCs). 24h after the last dose of the 8-week treatment schedule, the rats were euthanized, and their tissues were used to perform NCE and RET MN assays, the Pig-a RBC assay, Pig-a and Hprt lymphocyte gene mutation assays, the liver cII transgene mutation assay, and the liver Comet assay. The responses in the MN assays conducted at both sampling times, and all the gene mutation assays, were uniformly negative; however, the Comet assay was positive for the induction of liver DNA damage. As the positive responses in the Comet assay were seen only with doses in excess of the cancer bioassay doses, and at least one of these doses (30mg/kg) produced toxicity in the liver, the overall findings from the study are consistent with furan having a predominantly nongenotoxic MOA for cancer. Published by Elsevier B.V. JF - Mutation research AU - McDaniel, L Patrice AU - Ding, Wei AU - Dobrovolsky, Vasily N AU - Shaddock, Joseph G AU - Mittelstaedt, Roberta A AU - Doerge, Daniel R AU - Heflich, Robert H AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02/18/ PY - 2012 DA - 2012 Feb 18 SP - 72 EP - 78 VL - 742 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Furans KW - 0 KW - Mutagens KW - furan KW - UC0XV6A8N9 KW - Index Medicus KW - Rats KW - Animals KW - Mutagenicity Tests KW - Drug Administration Schedule KW - Animals, Genetically Modified KW - Male KW - Furans -- toxicity KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918033529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Genotoxicity+of+furan+in+Big+Blue+rats.&rft.au=McDaniel%2C+L+Patrice%3BDing%2C+Wei%3BDobrovolsky%2C+Vasily+N%3BShaddock%2C+Joseph+G%3BMittelstaedt%2C+Roberta+A%3BDoerge%2C+Daniel+R%3BHeflich%2C+Robert+H&rft.aulast=McDaniel&rft.aufirst=L&rft.date=2012-02-18&rft.volume=742&rft.issue=1-2&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrgentox.2011.12.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-03 N1 - Date created - 2012-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrgentox.2011.12.011 ER - TY - CPAPER T1 - Age and Sex Differences in Liver miRNA Expression During the Rat Life Cycle T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326136859; 6206129 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Kwekel, Joshua AU - Desai, Varsha AU - Han, Tao AU - Branham, William S AU - Moland, Carrie AU - Fuscoe, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Life cycle KW - Liver KW - Age KW - miRNA KW - Sex differences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326136859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Age+and+Sex+Differences+in+Liver+miRNA+Expression+During+the+Rat+Life+Cycle&rft.au=Kwekel%2C+Joshua%3BDesai%2C+Varsha%3BHan%2C+Tao%3BBranham%2C+William+S%3BMoland%2C+Carrie%3BFuscoe%2C+James&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - In silico Drug Repositioning Through Integrating Chemical, Biological and Clinical Properties T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326135638; 6206096 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Liu, Zhichao AU - Ding, Don AU - Reagan, Kelly AU - Fang, Hong AU - Tong, Weida Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=In+silico+Drug+Repositioning+Through+Integrating+Chemical%2C+Biological+and+Clinical+Properties&rft.au=Liu%2C+Zhichao%3BDing%2C+Don%3BReagan%2C+Kelly%3BFang%2C+Hong%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Knowledge Expansion, Network Modeling and Visualizations in Genomics and Proteomics T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326135593; 6206119 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Fang, Hong AU - Ding, Don AU - Ding, Yijun AU - Chen, Minjun AU - Liu, Zhichao AU - Xu, Xiaowei AU - Tong, Weida Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - proteomics KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326135593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Knowledge+Expansion%2C+Network+Modeling+and+Visualizations+in+Genomics+and+Proteomics&rft.au=Fang%2C+Hong%3BDing%2C+Don%3BDing%2C+Yijun%3BChen%2C+Minjun%3BLiu%2C+Zhichao%3BXu%2C+Xiaowei%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Data Mining for Identification of Bicluster Regions of HighDimensional T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326134481; 6206109 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Chen, Hung-Chia AU - Zou, Wen AU - Chen, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Mining KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326134481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Data+Mining+for+Identification+of+Bicluster+Regions+of+HighDimensional&rft.au=Chen%2C+Hung-Chia%3BZou%2C+Wen%3BChen%2C+James&rft.aulast=Chen&rft.aufirst=Hung-Chia&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - CPAPER T1 - Integration of ERCC probes into custom-designed DNA microarrays T2 - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AN - 1326134171; 6206121 JF - 9th Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2012) AU - Han, Tao AU - Moland, Carrie AU - Branham, William AU - Desai, Varsha AU - Fuscoe, James Y1 - 2012/02/17/ PY - 2012 DA - 2012 Feb 17 KW - Probes KW - DNA microarrays KW - Integration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1326134171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2012%29&rft.atitle=Integration+of+ERCC+probes+into+custom-designed+DNA+microarrays&rft.au=Han%2C+Tao%3BMoland%2C+Carrie%3BBranham%2C+William%3BDesai%2C+Varsha%3BFuscoe%2C+James&rft.aulast=Han&rft.aufirst=Tao&rft.date=2012-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.title=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.issn=&rft_id=info:doi/ L2 - http://mcbios.org/sites/default/files/MCBIOS_2012_Conference_Program_Final_Website_0.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-31 N1 - Last updated - 2013-04-12 ER - TY - GEN T1 - Nearly Half of College Student Treatment Admissions Were for Primary Alcohol Abuse. Data Spotlight AN - 968113421; ED529254 AB - Many students, and the public in general, believe that drinking alcohol is a normal part of the college experience. Unfortunately, students' efforts to "be sociable" or "fit in" can escalate into substance use behavior that puts their health and well-being at risk: One in four full-time college students have experienced past year alcohol abuse or dependence. In 2009, there were approximately 374,000 substance abuse treatment admissions aged 18 to 24. Nearly 12,000 of these admissions were college or other postsecondary school students. College student admissions were more likely than nonstudent admissions to report alcohol (46.6 vs. 30.6 percent) as their primary substance of abuse. College student and nonstudent admissions were equally likely to report marijuana as their primary substance of abuse (30.9 vs. 30.0 percent), and college student admissions were less likely than nonstudent admissions to report heroin (7.2 vs. 16.1 percent), other opiates (8.3 vs. 10.5 percent), cocaine (1.9 vs. 4.2 percent), or methamphetamine (1.0 vs. 4.4 percent) as their primary substance of abuse. (Contains 3 footnotes.) Y1 - 2012/02/07/ PY - 2012 DA - 2012 Feb 07 SP - 1 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Higher Education KW - Drinking KW - Substance Abuse KW - Counseling Services KW - Marijuana KW - Health Services KW - Risk KW - Alcohol Abuse KW - Student Attitudes KW - Help Seeking KW - Alcoholism KW - Health Behavior KW - College Students KW - Cocaine KW - Drug Rehabilitation KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968113421?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Isolation and structural characterization of two tadalafil analogs found in dietary supplements AN - 1837329145; 16092376 AB - During routine screenings of two "libido enhancer" dietary supplements using LC-MS super(n, two compounds were detected that displayed structural similarities to tadalafil. These compounds were isolated from the supplements using high-performance liquid chromatography with fraction collection, and were characterized further using accurate mass determination and NMR. "Compound 1" had an m/z of 434 for the [M+H]) super(+) ion, with a corresponding chemical formula of C sub(24H) sub(2)4N sub(3O) sub(5). "Compound 2" had an m/z of 432 for the [M+H] super(+ ion, with a corresponding chemical formula of C) sub(2)5H sub(26N) sub(3)O sub(4. Although mass spectrometry indicated that these modifications occurred in place of the -CH) sub(3) found on the pyrazinopyridoindole-1,4-dione of tadalafil, NMR was required to elucidate the correct configurations of these substitutions. The data obtained using NMR indicated that the structure of the -C sub(3H) sub(7)O moiety found in Compound 1 was 2-hydroxypropyl, and the -C sub(4H) sub(9) in Compound 2 was n-butyl. These new analogs were given the names 2-hydroxypropylnortadalafil and n-butylnortadalafil, respectively. JF - Journal of Pharmaceutical and Biomedical Analysis AU - Toomey, Valerie M AU - Litzau, Jonathan J AU - Flurer, Cheryl L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA, cheryl.flurer@fda.hhs.gov Y1 - 2012/02/05/ PY - 2012 DA - 2012 Feb 05 SP - 50 EP - 57 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 59 SN - 0731-7085, 0731-7085 KW - Toxicology Abstracts KW - Tadalafil analog KW - PDE-5 inhibitors KW - Dietary supplement KW - LC-MS KW - NMR KW - High-performance liquid chromatography KW - Data processing KW - Dietary supplements KW - N.M.R. KW - Mass spectroscopy KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837329145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Isolation+and+structural+characterization+of+two+tadalafil+analogs+found+in+dietary+supplements&rft.au=Toomey%2C+Valerie+M%3BLitzau%2C+Jonathan+J%3BFlurer%2C+Cheryl+L&rft.aulast=Toomey&rft.aufirst=Valerie&rft.date=2012-02-05&rft.volume=59&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2011.09.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Data processing; Dietary supplements; N.M.R.; Mass spectroscopy DO - http://dx.doi.org/10.1016/j.jpba.2011.09.038 ER - TY - CPAPER T1 - A mathematical framework for including various sources of variability in a task-based assessment of digital breast tomosynthesis T2 - 2012 Conference on Physics of Medical Imaging AN - 1313095324; 6147831 JF - 2012 Conference on Physics of Medical Imaging AU - Park, Subok AU - Badal-Soler, Andreu AU - Young, Stefano AU - Myers, Kyle Y1 - 2012/02/04/ PY - 2012 DA - 2012 Feb 04 KW - Medical imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313095324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=A+mathematical+framework+for+including+various+sources+of+variability+in+a+task-based+assessment+of+digital+breast+tomosynthesis&rft.au=Park%2C+Subok%3BBadal-Soler%2C+Andreu%3BYoung%2C+Stefano%3BMyers%2C+Kyle&rft.aulast=Park&rft.aufirst=Subok&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/documents/conferencesexhibitions/MI12-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Spatio-temporal Monte Carlo modeling of a-Se detectors for breast imaging: energy-weighted Swank noise and detective quantum efficiency T2 - 2012 Conference on Physics of Medical Imaging AN - 1313087449; 6147867 JF - 2012 Conference on Physics of Medical Imaging AU - Fang, Yuan AU - Badal-Soler, Andreu AU - Karim, Karim AU - Badano, Aldo Y1 - 2012/02/04/ PY - 2012 DA - 2012 Feb 04 KW - Monte Carlo simulation KW - Noise levels KW - Imaging techniques KW - Statistical analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313087449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=Spatio-temporal+Monte+Carlo+modeling+of+a-Se+detectors+for+breast+imaging%3A+energy-weighted+Swank+noise+and+detective+quantum+efficiency&rft.au=Fang%2C+Yuan%3BBadal-Soler%2C+Andreu%3BKarim%2C+Karim%3BBadano%2C+Aldo&rft.aulast=Fang&rft.aufirst=Yuan&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/documents/conferencesexhibitions/MI12-Final-lr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Preparation, certification and interlaboratory analysis of workplace air filters spiked with high-fired beryllium oxide AN - 968184977; 16507500 AB - Occupational sampling and analysis for multiple elements is generally approached using various approved methods from authoritative government sources such as the National Institute for Occupational Safety and Health (NIOSH), the Occupational Safety and Health Administration (OSHA) and the Environmental Protection Agency (EPA), as well as consensus standards bodies such as ASTM International. The constituents of a sample can exist as unidentified compounds requiring sample preparation to be chosen appropriately, as in the case of beryllium in the form of beryllium oxide (BeO). An interlaboratory study was performed to collect analytical data from volunteer laboratories to examine the effectiveness of methods currently in use for preparation and analysis of samples containing calcined BeO powder. NIST SRM registered 1877 high-fired BeO powder (1100 to 1200 degree C calcining temperature; count median primary particle diameter 0.12 mu m) was used to spike air filter media as a representative form of beryllium particulate matter present in workplace sampling that is known to be resistant to dissolution. The BeO powder standard reference material was gravimetrically prepared in a suspension and deposited onto 37 mm mixed cellulose ester air filters at five different levels between 0.5 mu g and 25 mu g of Be (as BeO). Sample sets consisting of five BeO-spiked filters (in duplicate) and two blank filters, for a total of twelve unique air filter samples per set, were submitted as blind samples to each of 27 participating laboratories. Participants were instructed to follow their current process for sample preparation and utilize their normal analytical methods for processing samples containing substances of this nature. Laboratories using more than one sample preparation and analysis method were provided with more than one sample set. Results from 34 data sets ultimately received from the 27 volunteer laboratories were subjected to applicable statistical analyses. The observed performance data show that sample preparations using nitric acid alone, or combinations of nitric and hydrochloric acids, are not effective for complete extraction of Be from the SRM 1877 refractory BeO particulate matter spiked on air filters; but that effective recovery can be achieved by using sample preparation procedures utilizing either sulfuric or hydrofluoric acid, or by using methodologies involving ammonium bifluoride with heating. Laboratories responsible for quantitative determination of Be in workplace samples that may contain high-fired BeO should use quality assurance schemes that include BeO-spiked sampling media, rather than solely media spiked with soluble Be compounds, and should ensure that methods capable of quantitative digestion of Be from the actual material present are used. JF - Journal of Environmental Monitoring AU - Oatts, T J AU - Hicks, CE AU - Adams, A R AU - Brisson, MJ AU - Youmans-McDonald, L D AU - Hoover, MD AU - Ashley, K AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, 45226, USA, KAshley@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 391 EP - 401 VL - 14 IS - 2 SN - 1464-0325, 1464-0325 KW - Health & Safety Science Abstracts; Environment Abstracts; Sustainability Science Abstracts; Pollution Abstracts KW - Filters KW - Pollutant removal KW - EPA KW - Air purification KW - Beryllium KW - Occupational safety KW - Temperature KW - Particulates KW - International standardization KW - M3 1010:Issues in Sustainable Development KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968184977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Preparation%2C+certification+and+interlaboratory+analysis+of+workplace+air+filters+spiked+with+high-fired+beryllium+oxide&rft.au=Oatts%2C+T+J%3BHicks%2C+CE%3BAdams%2C+A+R%3BBrisson%2C+MJ%3BYoumans-McDonald%2C+L+D%3BHoover%2C+MD%3BAshley%2C+K&rft.aulast=Oatts&rft.aufirst=T&rft.date=2012-02-01&rft.volume=14&rft.issue=2&rft.spage=391&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1016%2Fj.combustflame.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Filters; EPA; Pollutant removal; Air purification; Occupational safety; Beryllium; Temperature; Particulates; International standardization DO - http://dx.doi.org/10.1039/c1em10688k ER - TY - JOUR T1 - Occupational Health and Safety Surveillance and Research Using Workers' Compensation Data AN - 968166960; 16435505 AB - Objective: Examine uses of US workers' compensation (WC) data for occupational safety and health purposes. Methods: This article is a summary of the proceedings from an invitational workshop held in September 2009 to discuss the use of WC data for occupational safety and health prevention purposes. Results: Workers' compensation data systems, although limited in many ways, contain information such as medical treatments, their costs and outcomes, and disability causes that are unavailable from national occupational surveillance sources. Conclusions: Despite their limitations, WC records are collected in a manner consistent with many occupational health and safety surveillance needs. Reports are available on the use of WC data for surveillance and research purposes such as estimating the frequency, magnitude, severity, and cost of compensated injuries. Inconsistencies in WC data can limit generalization of research results. JF - Journal of Occupational and Environmental Medicine AU - Utterback, D F AU - Schnorr, T M AU - Silverstein, BA AU - Spieler, E A AU - Leamon, T B AU - Amick, BC III AD - CDC/NIOSH, 4676 Columbia Parkway, R-12, Cincinnati, OH 45226, USA, dutterback@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 171 EP - 176 VL - 54 IS - 2 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - workers' compensation KW - disabilities KW - Injuries KW - Occupational safety KW - prevention KW - Medical treatment KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968166960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Health+and+Safety+Surveillance+and+Research+Using+Workers%27+Compensation+Data&rft.au=Utterback%2C+D+F%3BSchnorr%2C+T+M%3BSilverstein%2C+BA%3BSpieler%2C+E+A%3BLeamon%2C+T+B%3BAmick%2C+BC+III&rft.aulast=Utterback&rft.aufirst=D&rft.date=2012-02-01&rft.volume=54&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823c14cb LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - workers' compensation; Injuries; disabilities; Occupational safety; prevention; Medical treatment; Occupational health DO - http://dx.doi.org/10.1097/JOM.0b013e31823c14cb ER - TY - JOUR T1 - Occupational Gradients in Smoking Behavior and Exposure to Workplace Environmental Tobacco Smoke The Multi-Ethnic Study of Atherosclerosis AN - 968166854; 16435501 AB - Objective: This study examines associations of occupation with smoking status, amount smoked among current and former smokers (number of cigarettes per day and lifetime cigarette consumption (pack-years)), and workplace exposure to environmental tobacco smoke (ETS) independent from income and education. Methods: This is a cross-sectional analysis of data from a community sample (n = 6355, age range: 45-84) using logistic and multinomial regression. All analyses were stratified by sex and adjusted for socio-demographic variables. Results: Male blue-collar and sales/office workers had higher odds of having consumed more than 20 pack-years of cigarettes than managers/professionals. For both male and female current or former smokers, exposure to workplace ETS was consistently and strongly associated with heavy smoking and greater pack-years. Conclusions: Blue-collar workplaces are associated with intense smoking and ETS exposure. Smoking must be addressed at both the individual and workplace levels especially in blue-collar workplaces. JF - Journal of Occupational and Environmental Medicine AU - Fujishiro, K AU - Stukovsky, KDH AU - Roux, AD AU - Landsbergis, P AU - Burchfiel, C AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Pkwy (R-15), Cincinnati, OH 45226, USA, kfujishiro@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 136 EP - 145 VL - 54 IS - 2 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Age KW - Behavior KW - Cigarettes KW - Education KW - Occupational exposure KW - Passive smoking KW - income KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968166854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Gradients+in+Smoking+Behavior+and+Exposure+to+Workplace+Environmental+Tobacco+Smoke+The+Multi-Ethnic+Study+of+Atherosclerosis&rft.au=Troy%2C+Tevi&rft.aulast=Troy&rft.aufirst=Tevi&rft.date=2012-02-01&rft.volume=133&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Commentary&rft.issn=00102601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Age; Education; Passive smoking; Behavior; Cigarettes; income; Occupational exposure DO - http://dx.doi.org/10.1097/JOM.0b013e318244501e ER - TY - JOUR T1 - Cronobacter spp. (previously Enterobacter sakazakii) invade and translocate across both cultured human intestinal epithelial cells and human brain microvascular endothelial cells AN - 968154229; 16164651 AB - The mechanism of Cronobacter pathogenesis in neonatal meningitis and potential virulence factors (aside from host cell invasion ability) remain largely unknown. To ascertain whether Cronobacter can invade and transcytose across intestinal epithelial cells, enter into the blood stream and then transcytose across the blood-brain-barrier, we have utilized human intestinal INT407 and Caco-2 cells and brain microvascular endothelial cell (HBMEC) monolayers on Transwell filters as experimental model systems. Our data indicate a wide range of heterogeneity with respect to invasion efficiency among twenty-three Cronobacter isolates screened. For selected isolates, we observed significant levels of transcytosis for Cronobacter sakazakii across tight monolayers of both Caco-2 and HBMEC, mimicking in vivo ability to cross the intestine as well as the blood brain barrier, and at a frequency equivalent to that of a control meningitis-causing Escherichia coli K1 strain. Finally, EM analysis demonstrated intracellular Cronobacter bacteria within host vacuoles in HBMEC, as well as transcytosed bacteria at the basolateral surface. These data reveal that certain Cronobacter isolates can invade and translocate across both cultured human intestinal epithelial cells and HBMEC, thus demonstrating a potential path for neonatal infections of the central nervous system (CNS) following oral ingestion. JF - Microbial Pathogenesis AU - Giri, Chandrakant P AU - Shima, Kensuke AU - Tall, Ben D AU - Curtis, Sherill AU - Sathyamoorthy, Venugopal AU - Hanisch, Brock AU - Kim, Kwang S AU - Kopecko, Dennis J AD - Laboratory of Enteric and Sexually Transmitted Diseases, DBPAP, OVRR, Center for Biologics Evaluation and Research, Food & Drug Administration, Bethesda, MD 20892, USA, chandrakant.giri@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 140 EP - 147 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 52 IS - 2 SN - 0882-4010, 0882-4010 KW - Microbiology Abstracts B: Bacteriology KW - Blood KW - Blood-brain barrier KW - Brain KW - Central nervous system KW - Data processing KW - Endothelial cells KW - Epithelial cells KW - Filters KW - Infection KW - Intestine KW - Meningitis KW - Microvasculature KW - Mimicry KW - Neonates KW - Vacuoles KW - virulence factors KW - Enterobacter sakazakii KW - Escherichia coli KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968154229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Pathogenesis&rft.atitle=Cronobacter+spp.+%28previously+Enterobacter+sakazakii%29+invade+and+translocate+across+both+cultured+human+intestinal+epithelial+cells+and+human+brain+microvascular+endothelial+cells&rft.au=Giri%2C+Chandrakant+P%3BShima%2C+Kensuke%3BTall%2C+Ben+D%3BCurtis%2C+Sherill%3BSathyamoorthy%2C+Venugopal%3BHanisch%2C+Brock%3BKim%2C+Kwang+S%3BKopecko%2C+Dennis+J&rft.aulast=Giri&rft.aufirst=Chandrakant&rft.date=2012-02-01&rft.volume=52&rft.issue=2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Microbial+Pathogenesis&rft.issn=08824010&rft_id=info:doi/10.1016%2Fj.micpath.2011.10.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Mimicry; Epithelial cells; Central nervous system; Microvasculature; Data processing; virulence factors; Blood-brain barrier; Brain; Infection; Meningitis; Filters; Endothelial cells; Blood; Vacuoles; Intestine; Neonates; Escherichia coli; Enterobacter sakazakii DO - http://dx.doi.org/10.1016/j.micpath.2011.10.003 ER - TY - JOUR T1 - Pulmonary Function and Left Ventricular Mass in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study AN - 923205085; 16304200 AB - Purpose: Impaired pulmonary function has been associated with increased cardiovascular disease incidence and mortality. The objective of this study was to investigate associations between pulmonary function and left ventricular (LV) mass. Methods: Participants were African American women (n = 1,069) and men (n = 555) aged 49-73 years, from the Atherosclerosis Risk in Communities study. Mean pulmonary function values at the first (1987-1989) and second (1990-1992) examinations were used. Echocardiograms were performed at the third and early in the fourth examinations (1993-1996). Analysis of covariance and linear regression were used to assess associations. Results: Mean levels of LV mass decreased with increasing quintiles of forced expiratory volume in one second (FEV1) among female never smokers (P = 0.039). Forced vital capacity (FVC) showed stronger associations than FEV1 with LV mass. Among men, LV mass was positively associated with FEV1 among current and never smokers, and with FVC among never smokers. Additional analyses among never smokers revealed significant inverse associations between LV mass and FVC among women with waist-to-hip ratios of >0.85 and those with no history of diabetes. In contrast, significant positive associations between LV mass and FVC were seen among male never smokers with body mass index (BMI) of less than or equal to 24.9 kg/m2, waist-to-hip ratios of less than or equal to 0.95, no history of hypertension or diabetes, and less than or equal to 60 years old. BMI and waist-to-hip ratio significantly modified associations among men. Conclusions: Among never smokers, LV mass and pulmonary function were inversely associated among women and positively associated among men. Further studies are warranted. (Echocardiography 2012; 29:131-139) JF - Echocardiography AU - Charles, Luenda E AU - Burchfiel, Cecil M AU - Andrew, Michael E AU - Gu, Ja K AU - Petrini, Marcy F AU - Butler, Jr Kenneth R AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 131 EP - 139 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 2 SN - 0742-2822, 0742-2822 KW - Biotechnology and Bioengineering Abstracts KW - Arteriosclerosis KW - Body mass index KW - Cardiovascular diseases KW - Diabetes mellitus KW - Echocardiography KW - Heart KW - Hypertension KW - Lung KW - Mortality KW - Ventricle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923205085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Echocardiography&rft.atitle=Pulmonary+Function+and+Left+Ventricular+Mass+in+African+Americans%3A+The+Atherosclerosis+Risk+in+Communities+%28ARIC%29+Study&rft.au=Charles%2C+Luenda+E%3BBurchfiel%2C+Cecil+M%3BAndrew%2C+Michael+E%3BGu%2C+Ja+K%3BPetrini%2C+Marcy+F%3BButler%2C+Jr+Kenneth+R&rft.aulast=Charles&rft.aufirst=Luenda&rft.date=2012-02-01&rft.volume=29&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Echocardiography&rft.issn=07422822&rft_id=info:doi/10.1111%2Fj.1540-8175.2011.01550.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Heart; Diabetes mellitus; Mortality; Ventricle; Lung; Echocardiography; Cardiovascular diseases; Arteriosclerosis; Body mass index; Hypertension DO - http://dx.doi.org/10.1111/j.1540-8175.2011.01550.x ER - TY - JOUR T1 - Continuing Medical Education Activity in Echocardiography AN - 923205075; 16304177 AB - Article Title: Pulmonary Function and Left Ventricular Mass in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study (Echocardiography 2012; 29:130) JF - Echocardiography AU - Fan, Pohoey AU - Charles, Luenda E AU - Burchfiel, Cecil M AU - Andrew, Michael E AU - Gu, Ja K AU - Petrini, Marcy F AU - Butler, Jr Kenneth R AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 130 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 2 SN - 0742-2822, 0742-2822 KW - Biotechnology and Bioengineering Abstracts KW - Arteriosclerosis KW - Echocardiography KW - Heart KW - Lung KW - Ventricle KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923205075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Echocardiography&rft.atitle=Continuing+Medical+Education+Activity+in+Echocardiography&rft.au=Fan%2C+Pohoey%3BCharles%2C+Luenda+E%3BBurchfiel%2C+Cecil+M%3BAndrew%2C+Michael+E%3BGu%2C+Ja+K%3BPetrini%2C+Marcy+F%3BButler%2C+Jr+Kenneth+R&rft.aulast=Fan&rft.aufirst=Pohoey&rft.date=2012-02-01&rft.volume=29&rft.issue=2&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Echocardiography&rft.issn=07422822&rft_id=info:doi/10.1111%2Fj.1540-8175.2011.01647.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Heart; Ventricle; Lung; Echocardiography; Arteriosclerosis DO - http://dx.doi.org/10.1111/j.1540-8175.2011.01647.x ER - TY - JOUR T1 - Work Experiences of Latina Immigrants: A Qualitative Study AN - 923201110; 16220723 AB - Almost half of the Latino immigrants working in the United States are women. However, studies concerning the work experiences of Latinas are almost absent in the literature. This article reports the findings from a qualitative study using eight focus groups (n = 53) of Latina immigrant workers. The focus group transcripts were analyzed using the grounded theory approach in which themes emerge from iterative readings of the transcripts by a group of investigators. This study identified themes related to excessive workload, familiar work/unfamiliar hazards, cultural tensions, lack of health care, pregnancy, sexual harassment, and family obligations/expectations. The responses of the Latina workers in this study clearly indicated that they live within a complex web of stressors, both as workers and as women. The increased economic opportunities that come with immigration to the United States are accompanied by many opportunities for exploitation, especially if they are undocumented. It is hoped that the findings of this study will raise awareness regarding these issues and spur further work in this area. JF - Journal of Career Development AU - Eggerth, Donald E AU - DeLaney, Sheli C AU - Flynn, Michael A AU - Jacobson, CJeff AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA  , deggerth@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 13 EP - 30 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 1 SN - 0894-8453, 0894-8453 KW - Sustainability Science Abstracts KW - Immigration KW - immigrants KW - sexual harassment KW - working conditions KW - careers KW - USA KW - Health care KW - Economics KW - Ethnic groups KW - culture KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/923201110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Career+Development&rft.atitle=Work+Experiences+of+Latina+Immigrants%3A+A+Qualitative+Study&rft.au=Eggerth%2C+Donald+E%3BDeLaney%2C+Sheli+C%3BFlynn%2C+Michael+A%3BJacobson%2C+CJeff&rft.aulast=Eggerth&rft.aufirst=Donald&rft.date=2012-02-01&rft.volume=39&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+Career+Development&rft.issn=08948453&rft_id=info:doi/10.1177%2F0894845311417130 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - careers; Immigration; Health care; immigrants; sexual harassment; Economics; working conditions; culture; Ethnic groups; USA DO - http://dx.doi.org/10.1177/0894845311417130 ER - TY - JOUR T1 - Use of a common laboratory glassware detergent improves recovery of Cryptosporidium parvum and Cyclospora cayetanensis from lettuce, herbs and raspberries AN - 920804744; 16263200 AB - The success of any protocol designed to detect parasitic protozoa on produce must begin with an efficient initial wash step. Cryptosporidium parvum and Cyclospora cayetanensis oocysts were seeded onto herbs, lettuces and raspberries, eluted with one of four wash solutions and the recovered number of oocysts determined via fluorescent microscopy. Recovery rates for fluorescein thiosemicarbazide labeled C. parvum oocysts seeded onto spinach and raspberries and washed with de-ionized water were 38.4 +/- 10.1% and 34.9 +/- 6.2%, respectively. Two alternative wash solutions viz. 1 M glycine, pH 5.5 and a detachment solution were tested also using labeled C. parvum seeded spinach and raspberries. No statistically significant difference was noted in the recovery rates. However, a wash solution containing 0.1% Alconox registered , a laboratory glassware detergent, resulted in a significant improvement in oocyst recovery. 72.6 +/- 6.6% C. parvum oocysts were recovered from basil when washed with 0.1% Alconox registered compared to 47.9 +/- 5.8% using detachment solution. Also, C. cayetanensis oocysts were seeded onto lettuces, herbs and raspberries and the recovery using de-ionized water were compared to 0.1% Alconox registered wash: basil 17.5 +/- 5.0% to 76.1 +/- 14.0%, lollo rosso lettuce 38.3 +/- 5.5% to 72.5 +/- 8.1%, Tango leaf lettuce 45.9 +/- 5.4% to 71.1 +/- 7.8% and spring mix (mesclun) 39.8 +/- 0.7% to 80.2 +/- 11.3%, respectively. These results suggest that the use of Alconox registered in a wash solution significantly improves recovery resulting in the detection of these parasitic protozoa on high risk foods. JF - International Journal of Food Microbiology AU - Shields, Joan M AU - Lee, Michelle Minjung AU - Murphy, Helen R AD - Division of Virulence Assessment, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food & Drug Administration, United States, Joan.Shields@hhs.fda.gov Y1 - 2012/02/01/ PY - 2012 DA - 2012 Feb 01 SP - 123 EP - 128 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 153 IS - 1-2 SN - 0168-1605, 0168-1605 KW - Aqualine Abstracts; Water Resources Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cryptosporidium KW - Oocysts KW - Cryptosporidium parvum KW - AQ 00001:Water Resources and Supplies KW - K:03420 KW - A:01330 KW - SW 7060:Research facilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920804744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Use+of+a+common+laboratory+glassware+detergent+improves+recovery+of+Cryptosporidium+parvum+and+Cyclospora+cayetanensis+from+lettuce%2C+herbs+and+raspberries&rft.au=Shields%2C+Joan+M%3BLee%2C+Michelle+Minjung%3BMurphy%2C+Helen+R&rft.aulast=Shields&rft.aufirst=Joan&rft.date=2012-02-01&rft.volume=153&rft.issue=1-2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2011.10.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Oocysts; Cryptosporidium parvum DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2011.10.025 ER - TY - JOUR T1 - In vitro enrofloxacin binding in human fecal slurries. AN - 918576272; 22178170 AB - Most antibiotic inactivation studies have been conducted through in vitro incubations of human use aminoglycosides, beta-lactams, and fluoroquinolones, usually at fecal concentrations expected with therapeutic dose regimens in humans and animals. Less is known about the inactivation of these molecules when ingested at concentrations consistent with residue levels present in animal-derived foods from antibiotic treated animals. In this investigation, we used the fluoroquinolone, enrofloxacin which is specifically marketed for veterinary medicine as test compound. Fecal suspensions at 10%, 25%, and 50% (w/v) were subjected to physicochemical and molecular characterization and used in the drug binding studies. The fecal binding of enrofloxacin added at concentrations of 0.06, 0.1, 1, 5, 15, 50, and 150 mg/L was determined in various fecal slurry suspensions using analytical chemistry and microbiological assay methods. There was consistent correlation between both assay methods. By the analytical chemistry assay, the 10%, 25% and 50% diluted autoclaved fecal samples dosed with enrofloxacin showed binding of 50±4.6%, 54±6.5% and 56±6.8% of the enrofloxacin, respectively. Binding of enrofloxacin to fecal contents occurred rapidly within 10 min and remained constant over the incubation period. Denaturing gradient gel electrophoreses and pyrosequencing analysis showed varied profiles of the bacterial composition of the human intestinal microbiota for fecal samples from different individuals. This study provided information on methodological questions that have concerned regulatory authorities on in vitro testing to determine if concentrations of veterinary antimicrobial agent residues entering the human colon remain microbiologically active. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Ahn, Youngbeom AU - Linder, Sean W AU - Veach, Brian T AU - Steve Yan, S AU - Haydée Fernández, A AU - Pineiro, Silvia A AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 74 EP - 84 VL - 62 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - DNA, Bacterial KW - Fluoroquinolones KW - RNA, Ribosomal, 16S KW - enrofloxacin KW - 3DX3XEK1BN KW - Index Medicus KW - Bacteria -- genetics KW - Denaturing Gradient Gel Electrophoresis KW - RNA, Ribosomal, 16S -- genetics KW - Humans KW - DNA, Bacterial -- genetics KW - Adsorption KW - Bacteria -- classification KW - Chromatography, High Pressure Liquid KW - Feces -- microbiology KW - Anti-Bacterial Agents -- metabolism KW - Anti-Bacterial Agents -- chemistry KW - Fluoroquinolones -- metabolism KW - Feces -- chemistry KW - Fluoroquinolones -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918576272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=In+vitro+enrofloxacin+binding+in+human+fecal+slurries.&rft.au=Ahn%2C+Youngbeom%3BLinder%2C+Sean+W%3BVeach%2C+Brian+T%3BSteve+Yan%2C+S%3BHayd%C3%A9e+Fern%C3%A1ndez%2C+A%3BPineiro%2C+Silvia+A%3BCerniglia%2C+Carl+E&rft.aulast=Ahn&rft.aufirst=Youngbeom&rft.date=2012-02-01&rft.volume=62&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.11.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-08 N1 - Date created - 2012-01-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.11.013 ER - TY - JOUR T1 - Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity. AN - 917577686; 22112502 AB - Circulating microRNAs (miRNAs) have emerged as novel noninvasive biomarkers for several diseases and other types of tissue injury. This study tested the hypothesis that changes in the levels of urinary miRNAs correlate with liver injury induced by hepatotoxicants. Sprague-Dawley rats were administered acetaminophen (APAP) or carbon tetrachloride (CCl(4)) and one nonhepatotoxicant (penicillin/PCN). Urine samples were collected over a 24 h period after a single oral dose of APAP (1250 mg/kg), CCl(4) (2000 mg/kg), or PCN (2400 mg/kg). APAP and CCl(4) induced liver injury based upon increased serum alanine and aspartate aminotransferase levels and histopathological findings, including liver necrosis. APAP and CCl(4) both significantly increased the urinary levels of 44 and 28 miRNAs, respectively. In addition, 10 of the increased miRNAs were in common between APAP and CCl(4). In contrast, PCN caused a slight decrease of a different nonoverlapping set of urinary miRNAs. Cluster analysis revealed a distinct urinary miRNA pattern from the hepatotoxicant-treated groups when compared with vehicle controls and PCN. Analysis of hepatic miRNA levels suggested that the liver was the source of the increased urinary miRNAs after APAP exposure; however, the results from CCl(4) were equivocal. Computational analysis was used to predict target genes of the 10 shared hepatotoxicant-induced miRNAs. Liver gene expression profiling using whole genome microarrays identified eight putative miRNA target genes that were significantly altered in the liver of APAP- and CCl(4)-treated animals. In conclusion, the patterns of urinary miRNA may hold promise as biomarkers of hepatotoxicant-induced liver injury. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Yang, Xi AU - Greenhaw, James AU - Shi, Qiang AU - Su, Zhenqiang AU - Qian, Feng AU - Davis, Kelly AU - Mendrick, Donna L AU - Salminen, William F AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 335 EP - 344 VL - 125 IS - 2 KW - Biomarkers KW - 0 KW - Genetic Markers KW - MicroRNAs KW - Penicillins KW - Acetaminophen KW - 362O9ITL9D KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Animals KW - Predictive Value of Tests KW - Alkaline Phosphatase -- blood KW - Risk Assessment KW - Rats KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Necrosis KW - Rats, Sprague-Dawley KW - Urinalysis KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Penicillins -- toxicity KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- urine KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- drug effects KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Chemical and Drug Induced Liver Injury -- genetics KW - Toxicity Tests -- methods KW - Liver -- metabolism KW - MicroRNAs -- urine KW - Carbon Tetrachloride -- toxicity KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917577686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Identification+of+urinary+microRNA+profiles+in+rats+that+may+diagnose+hepatotoxicity.&rft.au=Yang%2C+Xi%3BGreenhaw%2C+James%3BShi%2C+Qiang%3BSu%2C+Zhenqiang%3BQian%2C+Feng%3BDavis%2C+Kelly%3BMendrick%2C+Donna+L%3BSalminen%2C+William+F&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2012-02-01&rft.volume=125&rft.issue=2&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr321 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-17 N1 - Date created - 2012-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr321 ER - TY - JOUR T1 - Changes in mouse liver protein glutathionylation after acetaminophen exposure. AN - 917162967; 22045778 AB - The role of protein glutathionylation in acetaminophen (APAP)-induced liver injury was investigated in this study. A single oral gavage dose of 150 or 300 mg/kg APAP in B6C3F1 mice produced increased serum alanine aminotransferase and aspartate aminotransferase levels and liver necrosis in a dose-dependent manner. The ratio of GSH to GSSG was decreased in a dose-dependent manner, suggesting that APAP produced a more oxidizing environment within the liver. Despite the increased oxidation state, the level of global protein glutathionylation was decreased at 1 h and continued to decline through 24 h. Immunohistochemical localization of glutathionylated proteins showed a complex dynamic change in the lobule zonation of glutathionylated proteins. At 1 h after APAP exposure, the level of glutathionylation decreased in the single layer of hepatocytes around the central veins but increased mildly in the remaining centrilobular hepatocytes. This increase correlated with the immunohistochemical localization of APAP covalently bound to protein. Thereafter, the level of glutathionylation decreased dramatically over time in the centrilobular regions with major decreases observed at 6 and 24 h. Despite the overall decreased glutathionylation, a layer of cells lying between the undamaged periportal region and the damaged centrilobular hepatocytes exhibited high levels of glutathionylation at 3 and 6 h in all samples and in some 24-h samples that had milder injury. These temporal and zonal pattern changes in protein glutathionylation after APAP exposure indicate that protein glutathionylation may play a role in protein homeostasis during APAP-induced hepatocellular injury. JF - The Journal of pharmacology and experimental therapeutics AU - Yang, Xi AU - Greenhaw, James AU - Ali, Akhtar AU - Shi, Qiang AU - Roberts, Dean W AU - Hinson, Jack A AU - Muskhelishvili, Levan AU - Beger, Richard AU - Pence, Lisa M AU - Ando, Yosuke AU - Sun, Jinchun AU - Davis, Kelly AU - Salminen, William F AD - Division of Systems Biology, Food and Drug Administration/National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 360 EP - 368 VL - 340 IS - 2 KW - Proteins KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - 3-(cystein-S-yl)paracetamol KW - 6Q2X58Y8BP KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Glutathione KW - GAN16C9B8O KW - Glutathione Disulfide KW - ULW86O013H KW - Index Medicus KW - Chemical and Drug Induced Liver Injury -- blood KW - Animals KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- pathology KW - Glutathione Disulfide -- metabolism KW - Necrosis -- pathology KW - Mice KW - Hepatocytes -- pathology KW - Necrosis -- metabolism KW - Necrosis -- blood KW - Mice, Inbred Strains KW - Aspartate Aminotransferases -- blood KW - Alanine Transaminase -- blood KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Male KW - Hepatocytes -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - Acetaminophen -- administration & dosage KW - Liver -- pathology KW - Liver -- drug effects KW - Glutathione -- metabolism KW - Acetaminophen -- adverse effects KW - Liver -- metabolism KW - Acetaminophen -- analogs & derivatives KW - Acetaminophen -- metabolism KW - Proteins -- metabolism KW - Acetaminophen -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/917162967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Changes+in+mouse+liver+protein+glutathionylation+after+acetaminophen+exposure.&rft.au=Yang%2C+Xi%3BGreenhaw%2C+James%3BAli%2C+Akhtar%3BShi%2C+Qiang%3BRoberts%2C+Dean+W%3BHinson%2C+Jack+A%3BMuskhelishvili%2C+Levan%3BBeger%2C+Richard%3BPence%2C+Lisa+M%3BAndo%2C+Yosuke%3BSun%2C+Jinchun%3BDavis%2C+Kelly%3BSalminen%2C+William+F&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2012-02-01&rft.volume=340&rft.issue=2&rft.spage=360&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.111.187948 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-06 N1 - Date created - 2012-01-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2001 Jan;31(1):55-138 [11215692] J Biol Chem. 2011 Mar 18;286(11):9298-307 [21216949] Toxicol Appl Pharmacol. 2002 Jun 1;181(2):133-41 [12051997] J Pharmacol Exp Ther. 2002 Nov;303(2):468-75 [12388625] Toxicol Sci. 2003 Oct;75(2):458-67 [12883092] Hepatology. 2004 May;39(5):1267-76 [15122755] J Pharmacol Exp Ther. 1983 Dec;227(3):749-54 [6655568] Mol Pharmacol. 1985 Sep;28(3):306-11 [4033631] J Biol Chem. 1989 Jun 15;264(17):9814-9 [2524496] Chem Biol Interact. 1989;70(3-4):241-8 [2743472] J Biol Chem. 1990 Feb 25;265(6):3059-65 [2303440] Biochem Pharmacol. 1990 Sep 15;40(6):1211-8 [2403376] J Pharmacol Exp Ther. 1990 Dec;255(3):935-41 [2262912] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] Drug Metab Dispos. 1990 Nov-Dec;18(6):882-7 [1981532] Biochem Pharmacol. 1993 Mar 24;45(6):1251-9 [8466546] Arch Biochem Biophys. 1996 Nov 1;335(1):61-72 [8914835] Toxicol Lett. 1997 Jan 15;90(1):77-82 [9020405] J Pharmacol Exp Ther. 1997 Sep;282(3):1533-40 [9316869] J Biol Chem. 2004 Nov 12;279(46):47939-51 [15347644] J Hepatol. 2005 Jan;42(1):110-6 [15629515] Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):389-97 [16863451] Free Radic Biol Med. 2007 Sep 15;43(6):883-98 [17697933] J Biol Chem. 2007 Nov 9;282(45):32640-54 [17848555] Mol Interv. 2007 Dec;7(6):313-24 [18199853] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] J Nutr. 2008 Dec;138(12):2328-36 [19022953] Cancer Res. 2009 Oct 1;69(19):7626-34 [19773442] Handb Exp Pharmacol. 2010;(196):369-405 [20020268] J Biol Chem. 2010 May 28;285(22):17077-88 [20348099] Toxicol Sci. 2010 Jul;116(1):151-63 [20351055] Chem Res Toxicol. 2010 Jul 19;23(7):1286-92 [20578685] J Cell Biol. 2010 Aug 9;190(3):391-405 [20679432] J Biomed Sci. 2010;17 Suppl 1:S35 [20804611] Circulation. 2010 Dec 21;122(25):2699-708 [21135361] Biochem Pharmacol. 2001 Jan 15;61(2):245-52 [11163339] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/jpet.111.187948 ER - TY - JOUR T1 - Transferability of a modified embryonic stem cell test using a new endpoint for developmental neurotoxicity. AN - 916522715; 22082211 AB - We developed and analyzed a new surrogate endpoint of the mouse embryonic stem cell test (EST) for developmental neurotoxicity. To determine the sensitivity, specificity, and transferability of the new endpoint, a pre-validation team from three independent laboratories optimized and standardized the protocol for neuronal differentiation of mouse embryonic stem cells (mESCs) by measuring the neuronal differentiation rates of mESCs under different culture conditions, such as the presence or absence of basic fibroblast growth factor (bFGF) in the growth media and varying lengths of culture. In addition, a component ratio of neuronal cells was measured by using flow cytometry analysis of β-III tubulin (Tuj1)-positive cells and real-time polymerase chain reaction analysis of microtubule-associated protein 2 (MAP2) mRNA. Our results showed that the best growth was achieved by culturing mESCs for 12 d in N2B27 medium without bFGF or ascorbic acid. Lead (II) acetate and aroclor 1254 were used to test the usefulness of the new endpoint. When we used the known ID(50) values for lead (II) acetate in the EST model, it was classified as non-embryotoxic; however, when we used the new ID(50) values that we determined in this study, it was classified as weakly embryotoxic. Aroclor 1254 and penicillin G were also classified as weakly embryotoxic and non-embryotoxic compounds, respectively, when cardiac and neuronal differentiation ID(50) values were used. Therefore, our new surrogate endpoint for developmental neurotoxicity is not only sensitive and specific but also transferable among laboratories. JF - Toxicology mechanisms and methods AU - Baek, Dae Hyun AU - An, Su-Yeon AU - Park, Jae Hyun AU - Choi, Youngju AU - Park, Ki Dae AU - Kang, Jin Wook AU - Choi, Kyoung Suk AU - Park, Sung Hee AU - Whang, Min Young AU - Han, Jiyou AU - Kim, Jong-Hoon AU - Kim, Hyung Soo AU - Geum, Dongho AU - Yoo, Tae Moo AD - National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration , Cheongwon-gun, Chungcheongbuk-do Republic of Korea. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 118 EP - 130 VL - 22 IS - 2 KW - Chlorodiphenyl (54% Chlorine) KW - 11097-69-1 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Animals KW - Chlorodiphenyl (54% Chlorine) -- toxicity KW - Lead -- toxicity KW - Dose-Response Relationship, Drug KW - Mice KW - Cell Differentiation -- drug effects KW - NIH 3T3 Cells KW - Embryonic Stem Cells -- drug effects KW - Neurons -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916522715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Transferability+of+a+modified+embryonic+stem+cell+test+using+a+new+endpoint+for+developmental+neurotoxicity.&rft.au=Baek%2C+Dae+Hyun%3BAn%2C+Su-Yeon%3BPark%2C+Jae+Hyun%3BChoi%2C+Youngju%3BPark%2C+Ki+Dae%3BKang%2C+Jin+Wook%3BChoi%2C+Kyoung+Suk%3BPark%2C+Sung+Hee%3BWhang%2C+Min+Young%3BHan%2C+Jiyou%3BKim%2C+Jong-Hoon%3BKim%2C+Hyung+Soo%3BGeum%2C+Dongho%3BYoo%2C+Tae+Moo&rft.aulast=Baek&rft.aufirst=Dae&rft.date=2012-02-01&rft.volume=22&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2011.603394 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-04 N1 - Date created - 2012-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/15376516.2011.603394 ER - TY - JOUR T1 - Alternative models in developmental toxicology. AN - 916151196; 22239077 AB - In light of various pressures, toxicologists have been searching for alternative methods for safety testing of chemicals. According to a recent policy in the European Union (Regulation, Evaluation Authorisation and Restriction of Chemicals, REACH), it has been estimated that over the next twelve to fifteen years, approximately 30,000 chemicals may need to be tested for safety, and under current guidelines such testing would require the use of approximately 7.2 million laboratory animals [ Hofer et al. 2004 ]. It has also been estimated that over 80% of all animals used for safety testing under REACH legislation would be used for examining reproductive and developmental toxicity [Hofer et al., 2004]. In addition to REACH initiatives, it has been estimated that out of 5,000 to 10,000 new drug entities that a pharmaceutical company may start with, only one is finally approved by the Food and Drug Administration at a cost of over one billion dollars [ Garg et al. 2011 ]. A large portion of this cost is due to animal testing. Therefore, both the pharmaceutical and chemical industries are interested in using alternative models and in vitro tests for safety testing. This review will examine the current state of three alternative models - whole embryo culture (WEC), the mouse embryonic stem cell test (mEST), and zebrafish. Each of these alternatives will be reviewed, and advantages and disadvantages of each model will be discussed. These models were chosen because they are the models most commonly used and would appear to have the greatest potential for future applications in developmental toxicity screening and testing. JF - Systems biology in reproductive medicine AU - Lee, Hyung-yul AU - Inselman, Amy L AU - Kanungo, Jyotshnabala AU - Hansen, Deborah K AD - Division of Personalized Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 10 EP - 22 VL - 58 IS - 1 KW - Index Medicus KW - Rats KW - Animals KW - Embryonic Stem Cells -- drug effects KW - Humans KW - Mice KW - Embryonic Development -- drug effects KW - Zebrafish -- embryology KW - Cell Line KW - Risk Assessment KW - Embryo Culture Techniques KW - Models, Animal KW - Animal Testing Alternatives KW - Toxicity Tests -- methods KW - Developmental Biology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916151196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Systems+biology+in+reproductive+medicine&rft.atitle=Alternative+models+in+developmental+toxicology.&rft.au=Lee%2C+Hyung-yul%3BInselman%2C+Amy+L%3BKanungo%2C+Jyotshnabala%3BHansen%2C+Deborah+K&rft.aulast=Lee&rft.aufirst=Hyung-yul&rft.date=2012-02-01&rft.volume=58&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Systems+biology+in+reproductive+medicine&rft.issn=1939-6376&rft_id=info:doi/10.3109%2F19396368.2011.648302 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-16 N1 - Date created - 2012-01-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/19396368.2011.648302 ER - TY - JOUR T1 - Metabolomics data and the biomarker qualification process AN - 1709167485; 16369887 AB - Since its initial applications in healthcare research over a decade ago, metabolomics has matured into a technology that can now reliably detect and quantify hundreds of metabolites in biofluids and tissue samples. With substantial improvements in analytical capabilities in recent years, metabolomics now has the potential to provide sensitive and specific biomarkers of health and disease status, drug toxicity and therapeutic efficacy. Although many of the clinical biomarkers currently in use are metabolites such as glucose, cholesterol, and creatinine, few, if any, new metabolites (or panel of metabolites) derived from metabolomic analyses have been submitted to the FDA as biomarker candidates. Under a recent FDA draft Guidance for Industry from the Center for Drug Evaluation and Research (CDER), biomarkers discovered using metabolomics, like those derived from genetic, transcriptomic, and proteomic studies, may be submitted to CDER for consideration as new drug development tools and entered into a formal biomarker qualification process. The qualification process begins with a letter of intent from the submitter, followed by discussions with FDA and then the submission of data supporting the performance of the biomarker within a specific context of use. CDER forms a Biomarker Qualification Review Team at the start of the interactive process to advise the biomarker developer on the type of information important to support the proposed context of use, and review the data that evaluates the biomarker for the proposed context of use when the biomarker development appears complete and the full supporting data are submitted. Once qualified, a biomarker can be used in drug development within the qualified context of use without requesting additional regulatory review concerning its suitability. JF - Metabolomics AU - Beger, Richard D AU - Colatsky, Thomas AD - Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, Richard.Beger@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 2 EP - 7 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 8 IS - 1 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Glucose KW - Metabolites KW - Drug development KW - Toxicity KW - Cholesterol KW - biomarkers KW - Creatinine KW - Reviews KW - proteomics KW - Drugs KW - metabolomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709167485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolomics+data+and+the+biomarker+qualification+process&rft.au=Beger%2C+Richard+D%3BColatsky%2C+Thomas&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2012-02-01&rft.volume=8&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-011-0342-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Creatinine; Data processing; Reviews; Glucose; Drug development; Metabolites; Cholesterol; proteomics; Toxicity; Drugs; biomarkers; metabolomics DO - http://dx.doi.org/10.1007/s11306-011-0342-z ER - TY - JOUR T1 - Accelerating the Translation of Research into Practice in Long Term Services and Supports: A Critical Need for Federal Infrastructure at the Nexus of Aging and Disability AN - 1438554408; 201308202 AB - The nexus of aging and disability, characterized by the phenomenon of aging with a disability, will become more visible as the population ages and the number of people with disabilities surviving to midlife increases. This article addresses 3 interrelated issues critical to the fields of aging and disability: increasing demand for community-based long-term services and supports, a paucity of evidence-based programs demonstrating effectiveness in facilitating independence for those aging with a disability, and lack of a federal infrastructure to support coordinated investments in research-to-practice for this population. Suggestions for federal interagency collaborations are given, along with roles for key stakeholders. Adapted from the source document. JF - Journal of Gerontological Social Work AU - Washko, Michelle M AU - Campbell, Margaret AU - Tilly, Jane AD - Administration on Aging, U.S. Department of Health and Human Services, Washington, DC, USA michelle.washko@aoa.hhs.gov Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 112 EP - 125 PB - Taylor & Francis, Philadelphia PA VL - 55 IS - 2 SN - 0163-4372, 0163-4372 KW - aging with disability research translation practice KW - Physically Handicapped KW - Aging KW - Evidence Based Practice KW - Interest Groups KW - Interorganizational Networks KW - Effectiveness KW - article KW - 6127: social gerontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1438554408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gerontological+Social+Work&rft.atitle=Accelerating+the+Translation+of+Research+into+Practice+in+Long+Term+Services+and+Supports%3A+A+Critical+Need+for+Federal+Infrastructure+at+the+Nexus+of+Aging+and+Disability&rft.au=Washko%2C+Michelle+M%3BCampbell%2C+Margaret%3BTilly%2C+Jane&rft.aulast=Washko&rft.aufirst=Michelle&rft.date=2012-02-01&rft.volume=55&rft.issue=2&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gerontological+Social+Work&rft.issn=01634372&rft_id=info:doi/10.1080%2F01634372.2011.642471 LA - English DB - Social Services Abstracts N1 - Date revised - 2013-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JGSWDU N1 - SubjectsTermNotLitGenreText - Physically Handicapped; Aging; Interorganizational Networks; Interest Groups; Effectiveness; Evidence Based Practice DO - http://dx.doi.org/10.1080/01634372.2011.642471 ER - TY - GEN T1 - Enhanced Early Head Start with Employment Services: 42-Month Impacts from the Kansas and Missouri Sites of the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project. OPRE Report 2012-05 AN - 1314325796; ED539262 AB - MDRC is conducting the Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project under a contract with the Administration for Children and Families (ACF) in the U.S. Department of Health and Human Services (HHS). As part of the multisite Enhanced Services for the Hard-to-Employ Demonstration and Evaluation Project, MDRC, together with its research partners, is leading an evaluation of parental employment and educational services delivered within Early Head Start (Enhanced EHS). The program model tested here aims to dually address the employment and educational needs of parents who are at risk of unemployment and the developmental needs of their children. The study is sponsored by the U.S. Department of Health and Human Services, with additional funding from the U.S. Department of Labor. The study uses a rigorous random assignment design comparing outcomes for families and children who were offered Enhanced EHS with outcomes for those who could only access alternative services in the community. This report presents the final impact results approximately 42 months after families and children first entered the study. Key findings include: (1) Because of implementation challenges, the Enhanced EHS program's formalized employment, educational, and self-sufficiency enhancements were never fully integrated into core EHS services; (2) At the 42-month follow-up, Enhanced EHS did not significantly affect parental employment and economic outcomes, parenting practices, or child development and well-being among the full research sample; and (3) Enhanced EHS generated positive impacts on parental employment and economic outcomes for families who were expecting a child or who had an infant (a child younger than 12 months old) when they first entered the study. The results illustrate the challenges of integrating enhancements aimed at addressing parents' education, employment, and self-sufficiency needs into a two-generational program that is focused primarily on goals related to parenting, family interactions, and child development. In the context of these implementation difficulties, Enhanced EHS had limited long-term impacts for the full sample. Yet Enhanced EHS had positive long-term impacts on parental employment and earnings for families who had an infant or who were expecting a child at the outset of the study. This suggests that the approach may be effective for some families. Appended are: (1) Response Bias Analysis: 42-Month Survey of Parents and Direct Child Assessments; (2) Impacts on Child Care; and (3) Impacts on Employment. Individual chapters contain tables, boxes and footnotes. AU - Hsueh, JoAnn AU - Farrell, Mary E. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 126 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Kansas KW - Missouri KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - At Risk Persons KW - Program Effectiveness KW - Employment Services KW - Young Children KW - Well Being KW - Unemployment KW - Socioeconomic Status KW - Employment Opportunities KW - Employed Parents KW - Educational Needs KW - At Risk Students KW - Demonstration Programs KW - Parenting Styles KW - Family Programs KW - Child Rearing KW - Welfare Recipients KW - Early Intervention KW - Disadvantaged Youth KW - Child Development KW - Family Income KW - Program Evaluation KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1314325796?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - New Federal Policy Initiatives To Boost Health Literacy Can Help The Nation Move Beyond The Cycle Of Costly 'Crisis Care' AN - 1151043736; 2011-300667 AB - Health literacy is the capacity to understand basic health information and make appropriate health decisions. Tens of millions of Americans have limited health literacy-a fact that poses major challenges for the delivery of high-quality care. Despite its importance, health literacy has until recently been relegated to the sidelines of health care improvement efforts aimed at increasing access, improving quality and better managing costs. Recent federal policy initiatives, including the Affordable Care Act of 2010, the Department of Health and Human Services' National Action Plan to Improve Health Literacy, and the Plain Writing Act of 2010, have brought health literacy to a tipping point-that is, poised to make the transition from the margins to the mainstream. If public and private organizations make it a priority to become health literate, the nation's health literacy can be advanced to the point at which it will play a major role in improving health care and health for all Americans. Adapted from the source document. JF - Health Affairs AU - Koh, Howard K AU - Berwick, Donald M AU - Clancy, Carolyn M AU - Baur, Cynthia AU - Brach, Cindy AU - Harris, Linda M AU - Zerhusen, Eileen G AD - Department of Health and Human Services (HHS), in Washington, D.C Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 434 EP - 443 PB - Project HOPE, Bethesda MD VL - 31 IS - 2 SN - 0278-2715, 0278-2715 KW - Education and education policy - Adult, technical, and vocational education KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Economic conditions and policy - Economic theory KW - Cost KW - United States KW - Health policy KW - Medical service KW - Literacy KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1151043736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=New+Federal+Policy+Initiatives+To+Boost+Health+Literacy+Can+Help+The+Nation+Move+Beyond+The+Cycle+Of+Costly+%27Crisis+Care%27&rft.au=Koh%2C+Howard+K%3BBerwick%2C+Donald+M%3BClancy%2C+Carolyn+M%3BBaur%2C+Cynthia%3BBrach%2C+Cindy%3BHarris%2C+Linda+M%3BZerhusen%2C+Eileen+G&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2012-02-01&rft.volume=31&rft.issue=2&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff%2C2011.1169 LA - English DB - PAIS Index N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Literacy; Medical service; United States; Health policy; Legislation; Cost DO - http://dx.doi.org/10.1377/hlthaff,2011.1169 ER - TY - JOUR T1 - Serosorting and sexual risk behaviour according to different casual partnership types among MSM: the study of one-night stands and sex buddies AN - 1081895287; 201225276 AB - Among HIV-negative men who have sex with men (MSM), any incident of unprotected anal intercourse (UAI) between casual partners is usually regarded as risky for HIV transmission. However, men are increasingly using knowledge of their casual partner's HIV-status to reduce HIV risk during UAI (i.e., serosorting). Since familiarity between casual partners may lead to higher levels of UAI and serosorting, we examined how often men have UAI and practice serosorting with three types of casual partnerships that differ in their degree of familiarity. We included 240 HIV-negative men of the Amsterdam Cohort Study among MSM. We distinguished three types of casual partnerships: one-night stand ("met by chance and had sex only once"); multiple-time casual partner ("met and had sex with several times") and the "regular" casual partner ("sex buddy"). Serosorting was defined as UAI with an HIV-concordant partner. Generalised estimating equations analyses were used to examine the association between type of casual partnership and sexual risk behaviour. Analyses revealed that men with a sex buddy were more likely to have UAI than men with a one-night stand (OR [95%CI] 2.39 [1.39-4.09]). However, men with a sex buddy were also more likely to practice serosorting than men with a one-night stand (OR [95%CI] 5.20 [1.20-22.52]). Men with a sex buddy had more UAI but also reported more serosorting than men with a one-night stand. As a result, the proportion of UAI without serosorting is lower for men with a sex buddy, and therefore men might have less UAI at risk for HIV with this partner type. However, the protective value of serosorting with a sex buddy against HIV transmission needs to be further established. At this time, we suggest that a distinction between the one-night stand and the sex buddy should be incorporated in future studies as men behave significantly different with the two partner types. Adapted from the source document. JF - AIDS Care AU - van den Boom, Wijnand AU - Stolte, Ineke AU - Sandfort, Theo AU - Davidovich, Udi AD - Department of Research, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, Netherlands Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 167 EP - 173 PB - Taylor & Francis, Abingdon UK VL - 24 IS - 2 SN - 0954-0121, 0954-0121 KW - men who have sex with men serosorting sexual behaviour risk reduction behaviour types of casual partnerships unprotected anal intercourse KW - Safe sexual practices KW - Men KW - Cohort analysis KW - Partnerships KW - Risk reduction KW - Familiarity KW - HIV KW - At risk KW - Homosexuals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081895287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Serosorting+and+sexual+risk+behaviour+according+to+different+casual+partnership+types+among+MSM%3A+the+study+of+one-night+stands+and+sex+buddies&rft.au=van+den+Boom%2C+Wijnand%3BStolte%2C+Ineke%3BSandfort%2C+Theo%3BDavidovich%2C+Udi&rft.aulast=van+den+Boom&rft.aufirst=Wijnand&rft.date=2012-02-01&rft.volume=24&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2011.603285 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - AIDCEF N1 - SubjectsTermNotLitGenreText - Men; Partnerships; HIV; Homosexuals; Familiarity; Safe sexual practices; Cohort analysis; Risk reduction; At risk DO - http://dx.doi.org/10.1080/09540121.2011.603285 ER - TY - JOUR T1 - Obama Care at the Supreme Court: What will be at stake when the Justices hear the most controversial case of the 21st century? AN - 1081890835; 2011-283112 AB - On March 26, 2012, the Supreme Court will begin hearing five and a half hours of argument on the constitutionality of President Obamas health-care law. The court will be deciding on no fewer than four separate constitutional and policy issues relating to the law. At the end of this marathon session, the nine Justices will spend several months pondering whether the so-called Affordable Care Act will survive and serve as testimony to President Obama's ideological boldness -- or become a cautionary lesson in the foolhardiness of pursuing large-scale change without an ideological consensus across party lines. Adapted from the source document. JF - Commentary AU - Troy, Tevi AD - Hudson Institute, Department of Health and Human Services Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 20 EP - 24 PB - American Jewish Committee, New York, NY VL - 133 IS - 2 SN - 0010-2601, 0010-2601 KW - Government - Public officials KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Medicine and health care KW - Business and service sector - Insurance KW - Administration of justice - Courts and judicial power KW - Obama, Barack KW - United States Supreme court KW - Presidents KW - Courts KW - Health insurance KW - Law KW - Health policy KW - Medical service KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081890835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Commentary&rft.atitle=Obama+Care+at+the+Supreme+Court%3A+What+will+be+at+stake+when+the+Justices+hear+the+most+controversial+case+of+the+21st+century%3F&rft.au=Troy%2C+Tevi&rft.aulast=Troy&rft.aufirst=Tevi&rft.date=2012-02-01&rft.volume=133&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Commentary&rft.issn=00102601&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Obama, Barack; Presidents; Health policy; Law; United States Supreme court; Medical service; Health insurance; Legislation; Courts ER - TY - JOUR T1 - Environmental Engineering in IHS AN - 1038290931; 16313109 AB - The Indian Health Service (IHS), an agency of the Department of Health and Human Services, delivers a comprehensive environmental health program to American Indians and Alaska Natives through the Office of Environmental Health and Engineering (OEHE). One of the programs in OEHE is the Sanitation Facilities Construction (SFC) Program. The SFC designs and constructs water, sewer and solid waste infrastructure throughout Indian country. JF - Military Engineer AU - Baer, D AD - SFC dana.baer@ihs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 55 EP - 56 PB - Society of American Military Engineers VL - 104 IS - 675 SN - 0026-3982, 0026-3982 KW - Mechanical & Transportation Engineering Abstracts (MT); Materials Business File (MB); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - American Indians KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038290931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Military+Engineer&rft.atitle=Environmental+Engineering+in+IHS&rft.au=Baer%2C+D&rft.aulast=Baer&rft.aufirst=D&rft.date=2012-02-01&rft.volume=104&rft.issue=675&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Military+Engineer&rft.issn=00263982&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2014-02-14 ER - TY - JOUR T1 - Registration of work-related diseases, injuries, and complaints in Aruba, Bonaire, and Curaçao AN - 1037879198; 4330031 AB - ABSTRACT IN ENGLISH: Objective: To estimate the incidence of work-related diseases, injuries, and complaints in Aruba, Bonaire, and Curaçao and to identify some next steps in the prevention process. Methods: All of the three countries 18 occupational health specialists were asked to participate; 100% agreed to report all work-related diseases, injuries, and complaints in 2004-2008. A standard online notification form was used to register cases in a database maintained by the Netherlands Center for Occupational Diseases (NCOD). The public health service of Curaçao analyzed the data and presented the results to the participating physicians during educational and feedback meetings. Results: During the study period, 1 519 cases were reported: 720 (47.0%) work-related diseases; 515 (34.0%) injuries; and 284 (19.0%) complaints. The mean patient age was 42.4 years (range 16-70 years); 924 (60.8%) were males and 571 (37.6%), females. Most frequently reported were musculoskeletal diseases, injuries, and complaints; mental health disorders; and skin injuries. Analysis showed incidence rates of work-related diseases, injuries, and complaints in Aruba to be 157 new cases per 100 000 employee years; in Bonaire, 53/100 000; and in Curaçao, 437/100 000. Conclusions: These results suggest that labor protection laws need improvement and that preventive action should be fostered. Further study is needed on working conditions, preventive policy, and the quality of occupational health and safety practices in Aruba, Bonaire, and Curaçao. Funding is imperative for collecting and publishing accurate data, which will keep this problem on the social-political agenda. // ABSTRACT IN SPANISH: Objetivo: Calcular la incidencia de enfermedades, lesiones y sintomas relacionados con el trabajo en Aruba, Bonaire y Curazao e identificar los pasos siguientes en el proceso de prevención. Métodos: Se invitó a participar a los 18 especialistas en salud ocupacional de los usó un formulario estándar de notificación en linea para registrar los casos en una base de datos mantenida por el Centro para las Enfermedades Ocupacionales de los Países Bajos. El servicio de salud pública de Curazao analizó los datos y presentó los resultados a los médicos participantes durante las reuniones educativas y de retroalimentación. Resultados: Durante el periodo del estudio se notificaron 1 519 casos relacionados con el trabajo: 720 (47,0%) enfermedades, 515 (34,0%) lesiones y 284 (19,0%) síntomas. La edad promedio de los pacientes fue 42,4 años (recorrido, 16-70 años); 924 (60,8%) eran varones y 571 (37,6%), mujeres. Se notificaron con mayor frecuencia las enfermedades, lesiones y sintomas musculoesqueléticos; los trastornos mentales; y las lesiones cutáneas. El análisis mostró tasas de incidencia de enfermedades, lesiones y sintomas relacionados cor el trabajo de 157 nuevos casos por 100 000 empleados por año en Aruba, 53/100 000 en Bonaire y 437/100 000 en Curazao. Conclusiones: Estos resultados indican que las leyes de protección laboral deben mejorarse y que deben promoverse las medidas preventivas. Es necesario llevar a cabo otros estudios sobre las condiciones de trabajo, los planes de prevención y la calidad de la salud ocupacional y las prácticas de seguridad en Aruba, Bonaire y Curazao. Se requiere financiamiento para recopllar y publicar datos exactos, a fin de mantener este problema en la agenda politica y social. JF - Pan American journal of public health AU - Spreeuwers, Dick AU - Strikwerda, Dagmar C AU - Weel, Andre N.H. AD - University of Amsterdam ; Public Health Service, Willemstad ; Netherlands Society of Occupational Medicine Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 104 EP - 114 VL - 31 IS - 2 SN - 1020-4989, 1020-4989 KW - Sociology KW - Bonaire KW - Curaçao KW - Statistics KW - Doctors KW - Injuries KW - Aruba KW - Safety KW - Diseases KW - Working conditions KW - Public health KW - Occupational health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037879198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pan+American+journal+of+public+health&rft.atitle=Registration+of+work-related+diseases%2C+injuries%2C+and+complaints+in+Aruba%2C+Bonaire%2C+and+Cura%C3%A7ao&rft.au=Spreeuwers%2C+Dick%3BStrikwerda%2C+Dagmar+C%3BWeel%2C+Andre+N.H.&rft.aulast=Spreeuwers&rft.aufirst=Dick&rft.date=2012-02-01&rft.volume=31&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Pan+American+journal+of+public+health&rft.issn=10204989&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8847 5772; 11229; 6555 6220; 10449 5772; 3675 10299 13682 7883 8864; 12233; 3617 6220; 13713 4214; 28 77 14 ER - TY - JOUR T1 - Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings AN - 1034813520; 17013345 AB - Healthcare settings present a challenging environment for assessing low-level concentrations of specific volatile organic compounds (VOCs) in the presence of high background concentrations of alcohol from the use of hand sanitizers and surface disinfectants. The purposes of this laboratory-based project were to develop and validate a sampling and analysis methodology for quantifying low-level VOC concentrations as well as high-level alcohol concentrations found together in healthcare settings. Sampling was conducted using evacuated canisters lined with fused silica. Gas chromatography/mass spectrometry analysis was performed using preconcentration (for ppb levels) and loop injection (for ppm levels). For a select list of 14 VOCs, bias, precision, and accuracy of both the preconcentration and loop injection methods were evaluated, as was analyte stability in evacuated canisters over 30 days. Using the preconcentration (ppb-level) method, all validation criteria were met for 13 of the 14 target analytes-ethanol, acetone, methylene chloride, hexane, chloroform, benzene, methyl methacrylate, toluene, ethylbenzene, m,p-xylene, o-xylene, alpha-pinene, and limonene. Using the loop injection (ppm-level) method, all validation criteria were met for each analyte. At ppm levels, alpha-pinene and limonene remained stable over 21 days, while the rest of the analytes were stable for 30 days. All analytes remained stable over 30 days at ppb levels. This sampling and analysis approach is a viable (i.e., accurate and stable) methodology that will enable development of VOC profiles for mixed exposures experienced by healthcare workers. JF - Journal of Environmental Monitoring AU - LeBouf, Ryan F AU - Stefaniak, Aleksandr B AU - Virji, MAbbas AD - National Institute for Occupational Safety and Health; 1095 Willowdale Road; Morgantown; WV; USA; 26505; +304.285.5820; +304.285.6287; , rlebouf@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 977 EP - 983 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Environment Abstracts KW - Environmental monitoring KW - Alcohol KW - Toluene KW - Chlorides KW - Mass spectrometry KW - Medical personnel KW - Silica KW - Health care KW - Gas chromatography KW - Acetone KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 9999:GENERAL POLLUTION KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034813520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Validation+of+evacuated+canisters+for+sampling+volatile+organic+compounds+in+healthcare+settings&rft.au=LeBouf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B%3BVirji%2C+MAbbas&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10896h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 18 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Gas chromatography; Mass spectrometry; Alcohol; Silica; Health care; Toluene; Chlorides; Acetone; Medical personnel; Volatile organic compounds DO - http://dx.doi.org/10.1039/c2em10896h ER - TY - JOUR T1 - Use of denuder/filter apparatus to investigate terpene ozonolysis AN - 1034811750; 17013335 AB - A denuder/filter apparatus was used to collect the gaseous and particulate reaction products from ozonlysis of alpha -pinene, limonene and alpha -terpineol in an effort to develop sampling techniques for characterizing indoor environment chemistry. Carboxylic acids found in the particulate phase were derivatized to 2,2,2-trifuoroethylamides by reaction with 3-ethyl-1-[3-(dimethylamino)propyl]carbodiimide hydrochloride (EDC) and 2,2,2-trifluoroethylamine hydrochloride (TFEA). Carbonyl compounds collected in both gas phase and particulate phase were derivatized to their respective oximes by reaction with O-(2,3,4,5,6-pentafluoro-benzyl)hydroxylamine hydrochloride (PFBHA). The ozonolysis of alpha -pinene yielded the carboxylic acids: cis-pinonic acid and pinic acid and the proposed carboxylic acids methanetricarboxylic acid and terpenylic acid; the carbonyls: 4-oxopentanal, norpinonaldehyde, pinon aldehyde and the proposed carbonyl methylidenepropanedial. The ozonolysis of limonene yielded the carboxylic acids: limonic acid and pinic acid and the carbonyls: 1-(4-methylcyclohex-3-en-1-yl)ethanone (4AMCH), glyoxal, methyl glyoxal, 4-oxopentanal and 6-oxo-3-(prop-1-en-2-yl)heptanal (IPOH). The ozonolysis of alpha -terpineol yielded the proposed carboxylic acids: terpenylic acid and homoterpenylic acid and the carbonyls: (5E)-6-hydroxyhept-5-en-2-one, methyl glyoxal and 4-oxopentanal. JF - Journal of Environmental Monitoring AU - Wells, J R AD - Exposure Assessment Branch; Health Effects Laboratory Division; National Institute for Occupational Safety and Health; 1095 Willowdale Road; Morgantown; WV; 26505; USA; +1-304-285-6041; +1-304-285-6341; , ozw0@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 1044 EP - 1054 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Pollution Abstracts; Environment Abstracts KW - Filters KW - Carboxylic acids KW - Particulates KW - Aldehydes KW - Indoor environments KW - Carbonyl compounds KW - Ozonation KW - P 9999:GENERAL POLLUTION KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Use+of+denuder%2Ffilter+apparatus+to+investigate+terpene+ozonolysis&rft.au=Wells%2C+J+R&rft.aulast=Wells&rft.aufirst=J&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10799f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 69 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Filters; Carboxylic acids; Particulates; Indoor environments; Aldehydes; Carbonyl compounds; Ozonation DO - http://dx.doi.org/10.1039/c2em10799f ER - TY - JOUR T1 - Comparison of DNA extraction methodologies used for assessing fungal diversity viaITS sequencing AN - 1034811733; 17013334 AB - Traditional methods of assessing fungal exposure have been confounded by a number of limiting variables. The recent utilization of molecular methods such as internal transcribed spacer (ITS) sequencing of ribosomal RNA genes has provided improved insight into the diversity of fungal bioaerosols in indoor, outdoor and occupational environments. However, ITS analyses may also be confounded by a number of methodological limitations. In this study, we have optimized this technology for use in occupational or environmental studies. Three commonly used DNA extraction methodologies (UltraClean Soil kit, High Pure PCR Template kit, and EluQuik/DNeasy kit) were compared in terms of sensitivity and susceptibility to PCR inhibitors in dust for three common fungal bioaerosols, Aspergillus versicolor, Rhizopus microsporusand Wallemia sebi. Environmental dust samples were then studied using each extraction methodology and results were compared to viable culture data. The extraction methods differed in terms of their ability to efficiently extract DNA from particular species of fungi (e.g. Aspergillus versicolor). In addition, the ability to remove PCR inhibitors from dust samples was most effective using the soil DNA extraction kit. The species composition varied greatly between ITS clone libraries generated with the different DNA extraction kits. However, compared to viable culture data, ITS clone libraries included additional fungal species that are incapable of growth on solid culture medium. Collectively, our data indicated that DNA extraction methodologies used in ITS sequencing studies of occupational or environmental dust samples can greatly influence the fungal species that are detected. JF - Journal of Environmental Monitoring AU - Rittenour, William R AU - Park, Ju-Hyeong AU - Cox-Ganser, Jean M AU - Beezhold, Donald H AU - Green, Brett J AD - Allergy and Clinical Immunology Branch; Health Effects Laboratory Division; National Institute for Occupational Safety and Health; 1095 Willowdale Rd.; Morgantown; West Virginia; USA; +1 304-285-5721 ext 7; , ikx8@cdc.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 766 EP - 774 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 14 IS - 3 SN - 1464-0325, 1464-0325 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology; Environment Abstracts; Pollution Abstracts KW - Aerosols KW - Aspergillus versicolor KW - DNA KW - Dust KW - P 0000:AIR POLLUTION KW - K 03450:Ecology KW - N 14810:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034811733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Comparison+of+DNA+extraction+methodologies+used+for+assessing+fungal+diversity+viaITS+sequencing&rft.au=Rittenour%2C+William+R%3BPark%2C+Ju-Hyeong%3BCox-Ganser%2C+Jean+M%3BBeezhold%2C+Donald+H%3BGreen%2C+Brett+J&rft.aulast=Rittenour&rft.aufirst=William&rft.date=2012-02-01&rft.volume=14&rft.issue=3&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc2em10779a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Dust; DNA; Aspergillus versicolor DO - http://dx.doi.org/10.1039/c2em10779a ER - TY - JOUR T1 - Predicting perceived image quality: a critique of Lin and Kuo (2011). AN - 1024646515; pmid-22582691 AB - A recent study by Lin and Kuo reported on the image quality of a small mobile display under different ambient illumination levels. In this commentary, the present author discusses the limitations of their approach with respect to the rigorous quantification of image quality and the caveats associated with preference studies of new display technologies. Quantitatively predicting image quality using preference-based methods can be useful for initial decisions in early phases of product development, but provides limited value for the rigorous quantification of image quality of display devices. JF - Perceptual and motor skills AU - Badano, Aldo AD - Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA, Silver Spring, Maryland 20993, USA. aldo.badano@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 236 EP - 238 VL - 114 IS - 1 SN - 0031-5125, 0031-5125 KW - National Library of Medicine KW - *Cellular Phone KW - *Color Perception KW - Female KW - Humans KW - *Lighting KW - Male KW - *Pattern Recognition, Visual KW - *User-Computer Interface UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024646515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Predicting+perceived+image+quality%3A+a+critique+of+Lin+and+Kuo+%282011%29.&rft.au=Badano%2C+Aldo&rft.aulast=Badano&rft.aufirst=Aldo&rft.date=2012-02-01&rft.volume=114&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2012-06-11 N1 - SuppNotes - Comment On: Percept Mot Skills. 2011 Aug;113(1):215-28[21987921] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Measurement of impulse peak insertion loss for four hearing protection devices in field conditions AN - 1018377803; 201211413 AB - Objective: In 2009, the U.S. Environmental Protection Agency (EPA) proposed an impulse noise reduction rating (NRR) for hearing protection devices based upon the impulse peak insertion loss (IPIL) methods in the ANSI S12.42-2010 standard. This study tests the ANSI S12.42 methods with a range of hearing protection devices measured in field conditions. Design: The method utilizes an acoustic test fixture and three ranges for impulse levels: 130-134, 148-152, and 166-170 dB peak SPL. For this study, four different models of hearing protectors were tested: Bilsom 707 Impact II electronic earmuff, E.A.R Pod Express, E.A.R Combat Arms version 4, and the Etymotic Research, Inc. Electronic BlastPLG EB1. Study sample: Five samples of each protector were fitted on the fixture or inserted in the fixture's ear canal five times for each impulse level. Impulses were generated by a 0.223 caliber rifle. Results: The average IPILs increased with peak pressure and ranged between 20 and 38 dB. For some protectors, significant differences were observed across protector examples of the same model, and across insertions. Conclusions: The EPA's proposed methods provide consistent and reproducible results. The proposed impulse NRR rating should utilize the minimum and maximum protection percentiles as determined by the ANSI S12.42-2010 methods. Adapted from the source document. JF - International Journal of Audiology AU - Murphy, William J AU - Flamme, Gregory A AU - Meinke, Deanna K AU - Sondergaard, Jacob AU - Finan, Donald S AU - Lankford, James E AU - Khan, Amir AU - Vernon, Julia AU - Stewart, Michael AD - Hearing Loss Prevention Team, National Institute for Occupational Safety and Health Y1 - 2012/02// PY - 2012 DA - February 2012 SP - s31 EP - s42 PB - Informa Healthcare, Taylor and Francis, London UK VL - 51 IS - supplement 1 SN - 1499-2027, 1499-2027 KW - Hearing protection devices, impulse noise, noise reduction rating, noise-induced hearing loss KW - Measurement KW - Noise KW - Hearing protectors KW - Hearing KW - Hearing impairment KW - Arms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018377803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Measurement+of+impulse+peak+insertion+loss+for+four+hearing+protection+devices+in+field+conditions&rft.au=Murphy%2C+William+J%3BFlamme%2C+Gregory+A%3BMeinke%2C+Deanna+K%3BSondergaard%2C+Jacob%3BFinan%2C+Donald+S%3BLankford%2C+James+E%3BKhan%2C+Amir%3BVernon%2C+Julia%3BStewart%2C+Michael&rft.aulast=Murphy&rft.aufirst=William&rft.date=2012-02-01&rft.volume=51&rft.issue=supplement+1&rft.spage=s31&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.630330 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hearing; Arms; Hearing protectors; Hearing impairment; Measurement; Noise DO - http://dx.doi.org/10.3109/14992027.2011.630330 ER - TY - JOUR T1 - Tissue and cellular distribution of gold nanoparticles varies based on aggregation/agglomeration status AN - 1017980554; 16751406 AB - Aim: The ability of nanoparticles to form larger superstructures of aggregates and agglomerates has been extensively noted in the literature. The in vivo biological impact of these structures, however, has not been assessed. This knowledge gap is especially critical in the safety assessment of nanoparticles to be used for therapeutic purposes. Method/results: Here we show that when administered intravenously into a mouse model, gold nanoparticle superstructures of reversible agglomerates and irreversible aggregates demonstrate significant differences in organ and cellular distribution compared with the primary particle building blocks. In addition, different structures produced different blood serum chemistry data. Conclusion: These findings raise the possibility for different mechanisms of toxicity between the structures. Such a possibility necessitates complete characterization and stability assessment of nanomaterials prior to their in vivo administration. JF - Nanomedicine AU - Keene, Athena M AU - Peters, David AU - Rouse, Rodney AU - Stewart, Sharron AU - Rosen, Elliot T AU - Tyner, Katherine M AD - US FDA, Center for Drug Evaluation & Research, Office of Testing & Research, Division of Drug Safety Research, Building 64 Room 2086 HFD 910, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA., katherine.tyner@fda.hhs.gov Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 199 EP - 209 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 7 IS - 2 SN - 1743-5889, 1743-5889 KW - Biotechnology and Bioengineering Abstracts KW - Agglomeration KW - Animal models KW - Blood KW - Data processing KW - Gold KW - Therapeutic applications KW - Toxicity KW - nanoparticles KW - nanotechnology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017980554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine&rft.atitle=Tissue+and+cellular+distribution+of+gold+nanoparticles+varies+based+on+aggregation%2Fagglomeration+status&rft.au=Keene%2C+Athena+M%3BPeters%2C+David%3BRouse%2C+Rodney%3BStewart%2C+Sharron%3BRosen%2C+Elliot+T%3BTyner%2C+Katherine+M&rft.aulast=Keene&rft.aufirst=Athena&rft.date=2012-02-01&rft.volume=7&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Nanomedicine&rft.issn=17435889&rft_id=info:doi/10.2217%2Fnnm.11.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 32 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Blood; Data processing; Animal models; Therapeutic applications; Gold; Toxicity; nanoparticles; Agglomeration; nanotechnology DO - http://dx.doi.org/10.2217/nnm.11.125 ER - TY - JOUR T1 - Geostatistical modeling of the gas emission zone and its in-place gas content for Pittsburgh-seam mines using sequential Gaussian simulation AN - 1015462567; 2012-049606 AB - Determination of the size of the gas emission zone, the locations of gas sources within, and especially the amount of gas retained in those zones is one of the most important steps for designing a successful methane control strategy and an efficient ventilation system in longwall coal mining. The formation of the gas emission zone and the potential amount of gas-in-place (GIP) that might be available for migration into a mine are factors of local geology and rock properties that usually show spatial variability in continuity and may also show geometric anisotropy. Geostatistical methods are used here for modeling and prediction of gas amounts and for assessing their associated uncertainty in gas emission zones of longwall mines for methane control. This study used core data obtained from 276 vertical exploration boreholes drilled from the surface to the bottom of the Pittsburgh coal seam in a mining district in the Northern Appalachian basin. After identifying important coal and non-coal layers for the gas emission zone, univariate statistical and semivariogram analyses were conducted for data from different formations to define the distribution and continuity of various attributes. Sequential simulations performed stochastic assessment of these attributes, such as gas content, strata thickness, and strata displacement. These analyses were followed by calculations of gas-in-place and their uncertainties in the Pittsburgh seam caved zone and fractured zone of longwall mines in this mining district. Grid blanking was used to isolate the volume over the actual panels from the entire modeled district and to calculate gas amounts that were directly related to the emissions in longwall mines. Results indicated that gas-in-place in the Pittsburgh seam, in the caved zone and in the fractured zone, as well as displacements in major rock units, showed spatial correlations that could be modeled and estimated using geostatistical methods. This study showed that GIP volumes may change up to 3 MMscf per acre and, in a multi-panel district, may total 9 Bcf of methane within the gas emission zone. Therefore, ventilation and gas capture systems should be designed accordingly. In addition, rock displacements within the gas emission zone are spatially distributed. From an engineering and practical point of view, spatial distributions of GIP and distributions of rock displacements should be correlated with in-mine emissions and gob gas venthole productions. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Olea, Ricardo A AU - Goodman, Gerrit Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 50 EP - 71 PB - Elsevier, Amsterdam VL - 90-91 SN - 0166-5162, 0166-5162 KW - United States KW - North America KW - mining KW - Pittsburgh Coal KW - underground mining KW - Pennsylvanian KW - Paleozoic KW - natural gas KW - statistical analysis KW - data processing KW - Carboniferous KW - petroleum KW - coal seams KW - sedimentary rocks KW - longwall mining KW - Appalachian Basin KW - coal KW - digital simulation KW - coalbed methane KW - Pennsylvania KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1015462567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Geostatistical+modeling+of+the+gas+emission+zone+and+its+in-place+gas+content+for+Pittsburgh-seam+mines+using+sequential+Gaussian+simulation&rft.au=Karacan%2C+C+Ozgen%3BOlea%2C+Ricardo+A%3BGoodman%2C+Gerrit&rft.aulast=Karacan&rft.aufirst=C&rft.date=2012-02-01&rft.volume=90-91&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.10.010 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 40 N1 - Document feature - illus. incl. 16 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Appalachian Basin; Carboniferous; coal; coal seams; coalbed methane; data processing; digital simulation; longwall mining; mining; natural gas; North America; Paleozoic; Pennsylvania; Pennsylvanian; petroleum; Pittsburgh Coal; sedimentary rocks; statistical analysis; underground mining; United States DO - http://dx.doi.org/10.1016/j.coal.2011.10.010 ER - TY - RPRT T1 - Coaching as a Key Component in Teachers' Professional Development: Improving Classroom Practices in Head Start Settings. OPRE Report 2012-4 AN - 1011397262; ED530434 AB - Head Start CARES (Classroom-based Approaches and Resources for Emotion and Social Skill Promotion) is a large-scale, national research demonstration that was designed to test the effects of a one-year program aimed at improving pre-kindergarteners' social and emotional readiness for school. To facilitate the delivery of the program, teachers attended training workshops and worked with coaches throughout the school year. This report focuses on the planning and implementation of the coaching component in the Head Start CARES demonstration. Beginning with an overview of coaching as a model of professional development generally and the demonstration's coaching model in particular, the report then offers practical lessons learned about coaching social-emotional curricula in a large and complex early childhood education system. Geared toward early childhood education administrators and practitioners who are interested in adopting or modifying a coaching model, the lessons learned address the selection of the coaching model; coach hiring and training; coaching processes; coach support and supervision; and program management, data, and quality assurance. (Contains 4 tables, 1 box and 22 footnotes.) AU - Lloyd, Chrrishana M. AU - Modlin, Emmily L. Y1 - 2012/02// PY - 2012 DA - February 2012 SP - 32 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Workshops KW - Low Income Groups KW - Coaching (Performance) KW - Quality Assurance KW - Early Childhood Education KW - Professional Development KW - Teacher Effectiveness KW - Emotional Development KW - Interpersonal Competence KW - Early Intervention KW - Disadvantaged Youth KW - Teacher Recruitment KW - Social Development KW - Preschool Children KW - School Readiness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011397262?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Detonability of natural gas-air mixtures AN - 1010894037; 16188609 AB - Direct initiation experiments were carried out in a 105 cm diameter tube to study detonation properties and evaluate the detonability limits for mixtures of natural gas (NG) with air. The natural gas was primarily methane with 1.5-1.7% of ethane. A stoichiometric methane-oxygen mixture contained in a large plastic bag was used as a detonation initiator. Self-supporting detonations with velocities and pressures close to theoretical CJ values were observed in NG-air mixtures containing from 5.3% to 15.6% of NG at atmospheric pressure. These detonability limits are wider than previously measured in smaller channels, and close to the flammability limits. Detonation cell patterns recorded near the limits vary from large cells of the size of the tube to spiral traces of spin detonations. Away from the limits, detonation cell sizes decrease to about 20 cm for 10% NG, and are consistent with existing data for methane-air mixtures obtained in smaller channels. Observed cell patterns are very irregular, and contain secondary cell structures inside primary cells and fine structures inside spin traces. JF - Combustion and Flame AU - Gamezo, Vadim N AU - Zipf, RKarl AU - Sapko, Michael J AU - Marchewka, Walter P AU - Mohamed, Khaled M AU - Oran, Elaine S AU - Kessler, David A AU - Weiss, Eric S AU - Addis, James D AU - Karnack, Frank A AU - Sellers, Donald D AD - Office of Mine Safety and Health Research (OMSHR), National Institute for Occupational Safety and Health (NIOSH), Pittsburgh, PA 15236, USA gamezo@lcp.nrl.navy.mil Y1 - 2012/02// PY - 2012 DA - Feb 2012 SP - 870 EP - 881 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 159 IS - 2 SN - 0010-2180, 0010-2180 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); Aerospace & High Technology Database (AH) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010894037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Combustion+and+Flame&rft.atitle=Detonability+of+natural+gas-air+mixtures&rft.au=Gamezo%2C+Vadim+N%3BZipf%2C+RKarl%3BSapko%2C+Michael+J%3BMarchewka%2C+Walter+P%3BMohamed%2C+Khaled+M%3BOran%2C+Elaine+S%3BKessler%2C+David+A%3BWeiss%2C+Eric+S%3BAddis%2C+James+D%3BKarnack%2C+Frank+A%3BSellers%2C+Donald+D&rft.aulast=Gamezo&rft.aufirst=Vadim&rft.date=2012-02-01&rft.volume=159&rft.issue=2&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Combustion+and+Flame&rft.issn=00102180&rft_id=info:doi/10.1016%2Fj.combustflame.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-05-04 DO - http://dx.doi.org/10.1016/j.combustflame.2011.08.009 ER - TY - JOUR T1 - Meat consumption and the risk of incident distal colon and rectal adenoma. AN - 919649675; 22166801 AB - Most studies of meat and colorectal adenoma have investigated prevalent events from a single screening, thus limiting our understanding of the role of meat and meat-related exposures in early colorectal carcinogenesis. Among participants in the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial who underwent baseline and follow-up sigmoidoscopy (n=17,072), we identified 1008 individuals with incident distal colorectal adenoma. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between meat and meat-related components and incident distal colorectal adenoma using multivariate logistic regression. We observed suggestive positive associations for red meat, processed meat, haeme iron, and nitrate/nitrite with distal colorectal adenoma. Grilled meat (OR=1.56, 95% CI=1.04-2.36), well or very well-done meat (OR=1.59, 95% CI=1.05-2.43), 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) (OR=1.75, 95% CI=1.17-2.64), benzo[a]pyrene (OR=1.53, 95% CI=1.06-2.20), and total mutagenic activity (OR=1.57, 95% CI=1.03-2.40) were positively associated with rectal adenoma. Total iron (diet and supplements) (OR=0.69, 95% CI=0.56-0.86) and iron from supplements (OR=0.65, 95% CI=0.44-0.97) were inversely associated with any distal colorectal adenoma. Our findings indicate that several meat-related components may be most relevant to early neoplasia in the rectum. In contrast, total iron and iron from supplements were inversely associated with any distal colorectal adenoma. JF - British journal of cancer AU - Ferrucci, L M AU - Sinha, R AU - Huang, W-Y AU - Berndt, S I AU - Katki, H A AU - Schoen, R E AU - Hayes, R B AU - Cross, A J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2012/01/31/ PY - 2012 DA - 2012 Jan 31 SP - 608 EP - 616 VL - 106 IS - 3 KW - Index Medicus KW - Sigmoidoscopy KW - Colon -- pathology KW - Risk Factors KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Meat KW - Adenoma -- epidemiology KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Colorectal Neoplasms -- epidemiology KW - Colorectal Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919649675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Meat+consumption+and+the+risk+of+incident+distal+colon+and+rectal+adenoma.&rft.au=Ferrucci%2C+L+M%3BSinha%2C+R%3BHuang%2C+W-Y%3BBerndt%2C+S+I%3BKatki%2C+H+A%3BSchoen%2C+R+E%3BHayes%2C+R+B%3BCross%2C+A+J&rft.aulast=Ferrucci&rft.aufirst=L&rft.date=2012-01-31&rft.volume=106&rft.issue=3&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fbjc.2011.549 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-27 N1 - Date created - 2012-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 2011;63(4):583-92 [21598178] Carcinogenesis. 2011 Feb;32(2):203-9 [21081473] Cancer Prev Res (Phila). 2011 Oct;4(10):1686-97 [21803984] Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Cancer Epidemiol Biomarkers Prev. 2000 Jun;9(6):625-30 [10868699] Carcinogenesis. 2000 Oct;21(10):1909-15 [11023550] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] Nutr Rev. 2001 May;59(5):140-8 [11396694] Jpn J Cancer Res. 2002 May;93(5):478-83 [12036442] Mutat Res. 2002 Aug 26;519(1-2):151-61 [12160900] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Mutat Res. 2002 Sep 30;506-507:205-14 [12351160] Am J Epidemiol. 2003 Mar 1;157(5):434-45 [12615608] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] J Natl Cancer Inst. 2004 Mar 3;96(5):403-7 [14996862] J Nutr. 2004 Apr;134(4):776-84 [15051825] Eur J Cancer Prev. 2004 Jun;13(3):159-64 [15167213] Carcinogenesis. 2004 Jul;25(7):1211-8 [14988221] J Nutr. 2004 Oct;134(10):2711-6 [15465771] Mutat Res. 1975 Dec;31(6):347-64 [768755] Int J Cancer. 1981;27(4):471-4 [7275353] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Carcinogenesis. 1991 Aug;12(8):1503-6 [1860171] Int J Cancer. 1991 Oct 21;49(4):520-5 [1917152] J Natl Cancer Inst. 1992 Jan 15;84(2):91-8 [1310511] Int J Cancer. 1994 Feb 1;56(3):379-82 [8314326] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Am J Epidemiol. 1995 Oct 1;142(7):692-8 [7572938] Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):503-7 [8827353] Am J Epidemiol. 1996 Dec 1;144(11):1005-14 [8942430] Cancer Epidemiol Biomarkers Prev. 1997 Dec;6(12):1029-32 [9419398] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):15-24 [9950235] Lancet. 1999 Feb 27;353(9154):703-7 [10073512] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Cancer Res. 1999 Sep 1;59(17):4320-4 [10485479] Cancer Lett. 1999 Sep 1;143(2):189-94 [10503902] J Natl Cancer Inst. 2005 Feb 2;97(3):232-3; author reply 233-4 [15687367] Carcinogenesis. 2005 Mar;26(3):637-42 [15579480] J Natl Cancer Inst. 2005 Jun 15;97(12):917-26 [15956653] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Am J Gastroenterol. 2005 Dec;100(12):2789-95 [16393237] Int J Cancer. 2006 Jun 15;118(12):3147-52 [16425287] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):717-25 [16614114] Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1120-5 [16775169] Am J Epidemiol. 2006 Dec 1;164(11):1085-93 [16990408] Med Hypotheses. 2007;68(3):562-4 [17045417] Int J Cancer. 2007 Jul 1;121(1):136-42 [17354224] Carcinogenesis. 2007 Jun;28(6):1210-6 [17277235] Br J Cancer. 2007 Jul 2;97(1):118-22 [17551493] Carcinogenesis. 2007 Sep;28(9):2019-27 [17690112] Am J Clin Nutr. 2009 May;89(5):1418-24 [19261727] Am J Gastroenterol. 2009 May;104(5):1231-40 [19367270] Cancer Res. 2010 Mar 15;70(6):2406-14 [20215514] Cancer Prev Res (Phila). 2011 Sep;4(9):1465-75 [21685236] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/bjc.2011.549 ER - TY - BOOK T1 - A Bibliography of Studies Using Temporary Assistance for Needy Families (TANF)-Linked Administrative Data AN - 1266175296; 2011-360444 AB - Since its inception in 1996, the Temporary Assistance for Needy Families (TANF) program has been subject to much study. Some of this work has involved linking TANF administrative data to other administrative data sources, either to improve program administration or to answer program and research questions. Researchers, program administrators, and policy makers considering similar linkages to address research, programmatic, and operational questions can learn from past efforts. This report describes the use of administrative data for program administration and provides a bibliography of TANF research involving linked administrative data. Tables, References. JF - Urban Institute, Jan 31 2012, 46 pp. AU - Johnson, Paul AU - Kaminski, James AU - Scott, Molly M AU - Whitesell, Anne Y1 - 2012/01/31/ PY - 2012 DA - 2012 Jan 31 PB - Urban Institute KW - Social conditions and policy - Urban conditions KW - Social conditions and policy - Marriage and family life KW - Social conditions and policy - Social policy and social development KW - Education and education policy - Information services and sources KW - Social conditions and policy - Social conditions and problems KW - Economic conditions and policy - Economic conditions KW - Poverty relief KW - Bibliography KW - Poverty KW - Urban policy KW - Family KW - Social policy KW - Social insurance KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266175296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+Paul%3BKaminski%2C+James%3BScott%2C+Molly+M%3BWhitesell%2C+Anne&rft.aulast=Johnson&rft.aufirst=Paul&rft.date=2012-01-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.title=A+Bibliography+of+Studies+Using+Temporary+Assistance+for+Needy+Families+%28TANF%29-Linked+Administrative+Data&rft.issn=&rft_id=info:doi/ L2 - http://www.urban.org/UploadedPDF/412540-A-Bibliography-of-Studies-Using-Temporary-Assistance-for-Needy-Families-Linked-Administrative-Data.pdf LA - English DB - PAIS Index N1 - Date revised - 2013-01-01 N1 - Publication note - Urban Institute, 2012 N1 - Last updated - 2016-09-28 ER - TY - CPAPER T1 - Expression Profiles of Human Interferon-alpha and Interferon-lambda Subtypes Are Ligand- and Cell- Dependent T2 - 10th Cytokines and Inflammation Conference AN - 1313110112; 6154687 JF - 10th Cytokines and Inflammation Conference AU - Rabin, Ronald Y1 - 2012/01/30/ PY - 2012 DA - 2012 Jan 30 KW - a-Interferon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313110112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Cytokines+and+Inflammation+Conference&rft.atitle=Expression+Profiles+of+Human+Interferon-alpha+and+Interferon-lambda+Subtypes+Are+Ligand-+and+Cell-+Dependent&rft.au=Rabin%2C+Ronald&rft.aulast=Rabin&rft.aufirst=Ronald&rft.date=2012-01-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Cytokines+and+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/index.php?option=com_conference&file=program&cn=10th%20Cytokines%20and%20Inflammation%20Conference&cid=51 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. AN - 912643977; 22085607 AB - Occupational exposure to welding fumes (WF) is thought to cause Parkinson's disease (PD)-like neurological dysfunction. An apprehension that WF may accelerate the onset of PD also exists. Identifying reliable biomarkers of exposure and neurotoxicity are therefore critical for biomonitoring and neurological risk characterization of WF exposure. Manganese (Mn) in welding consumables is considered the causative factor for the neurological deficits seen in welders. Hence, we sought to determine if Mn accumulation in blood or nail clippings can be a marker for adverse exposure and neurotoxicity. To model this, rats were exposed by intratracheal instillation to dissolved or suspended fume components collected from gas metal arc-mild steel (GMA-MS) or manual metal arc-hard surfacing (MMA-HS) welding. Trace element analysis revealed selective Mn accumulation in dopaminergic brain areas, striatum (STR) and midbrain (MB), following exposure to the two fumes. This caused dopaminergic abnormality as evidenced by loss of striatal tyrosine hydroxylase (Th; 25-32% decrease) and Parkinson disease (autosomal recessive, early onset) 7 (Park7; 25-46% decrease) proteins. While blood Mn was not detectable, Mn levels in nails strongly correlated with the pattern of Mn accumulation in the striatum (R(2)=0.9386) and midbrain (R(2)=0.9332). Exposure to manganese chloride (MnCl(2)) caused similar Mn accumulation in STR, MB and nail. Our findings suggest that nail Mn has the potential to be a sensitive and reliable biomarker for long-term Mn exposure and associated neurotoxicity. The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Andrews, Ronnee N AU - Kashon, Michael L AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2012/01/27/ PY - 2012 DA - 2012 Jan 27 SP - 73 EP - 82 VL - 291 IS - 1-3 KW - Air Pollutants, Occupational KW - 0 KW - Biomarkers KW - Metals KW - Manganese KW - 42Z2K6ZL8P KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Dopamine -- physiology KW - Brain -- metabolism KW - Tissue Distribution KW - Lung -- metabolism KW - Metals -- analysis KW - Metals -- pharmacokinetics KW - Rats KW - Rats, Sprague-Dawley KW - Blotting, Western KW - Atmosphere Exposure Chambers KW - Environmental Monitoring -- methods KW - Male KW - Manganese -- metabolism KW - Air Pollutants, Occupational -- adverse effects KW - Air Pollutants, Occupational -- toxicity KW - Manganese Poisoning -- metabolism KW - Nails -- metabolism KW - Manganese -- adverse effects KW - Inhalation Exposure -- analysis KW - Biomarkers -- analysis KW - Hoof and Claw -- metabolism KW - Welding KW - Occupational Exposure -- adverse effects KW - Manganese -- pharmacokinetics KW - Nails -- chemistry KW - Occupational Exposure -- analysis KW - Hoof and Claw -- chemistry KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912643977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Manganese+accumulation+in+nail+clippings+as+a+biomarker+of+welding+fume+exposure+and+neurotoxicity.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BAndrews%2C+Ronnee+N%3BKashon%2C+Michael+L%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2012-01-27&rft.volume=291&rft.issue=1-3&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.10.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-06 N1 - Date created - 2011-12-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2011.10.021 ER - TY - JOUR T1 - Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients AN - 926880435; 16297584 AB - Unlike professional caregivers such as physicians and nurses, informal caregivers, typically family members or friends, provide care to individuals with a variety of conditions including advanced age, dementia, and cancer. This experience is commonly perceived as a chronic stressor, and caregivers often experience negative psychological, behavioral, and physiological effects on their daily lives and health. In this report, we describe the experience of a 53-year-old woman who is the sole caregiver for her husband, who has acute myelogenous leukemia and was undergoing allogeneic hematopoietic stem cell transplantation. During his intense and unpredictable course, the caregiver's burden is complex and complicated by multiple competing priorities. Because caregivers are often faced with multiple concurrent stressful events and extended, unrelenting stress, they may experience negative health effects, mediated in part by immune and autonomic dysregulation. Physicians and their interdisciplinary teams are presented daily with individuals providing such care and have opportunity to intervene. This report describes a case that exemplifies caregiving burden and discusses the importance of identifying caregivers at risk of negative health outcomes and intervening to attenuate the stress associated with the caregiving experience. JF - JAMA: Journal of the American Medical Association AU - Bevans, Margaret AU - Sternberg, Esther M AD - Author Affiliations: US Public Health Service, Clinical Nurse Scientist, Nursing Research & Translational Science, Nursing & Patient Care Services, Health Clinical Center (Dr Bevans) Y1 - 2012/01/25/ PY - 2012 DA - 2012 Jan 25 SP - 398 EP - 403 PB - American Medical Association, 515 N. State St. Chicago IL 60610 United States VL - 307 IS - 4 SN - 0098-7484, 0098-7484 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Dementia disorders KW - Leukemia KW - Medical personnel KW - Nursing KW - Perception KW - Psychology KW - Stem cells KW - Stress KW - dementia disorders KW - nursing KW - stem cells KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926880435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Caregiving+Burden%2C+Stress%2C+and+Health+Effects+Among+Family+Caregivers+of+Adult+Cancer+Patients&rft.au=Bevans%2C+Margaret%3BSternberg%2C+Esther+M&rft.aulast=Bevans&rft.aufirst=Margaret&rft.date=2012-01-25&rft.volume=307&rft.issue=4&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Leukemia; Stem cells; Psychology; Perception; stem cells; Nursing; Dementia disorders; Stress; dementia disorders; nursing; Medical personnel; Cancer ER - TY - CPAPER T1 - Quality by Design and Analytical Methods T2 - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AN - 1313096587; 6118171 JF - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AU - Moore, Christine Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313096587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=Quality+by+Design+and+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://isranalytica.org.il/Isranalytica2012/Scientific%20Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Quality by Design in Process Analytical Technology (PAT) and Real Time Release Testing (RTRT) Analytical Methods T2 - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AN - 1312981238; 6118177 JF - 15th Annual Meeting of the Israel Analytical Chemistry Society (ISRANALYTICA 2012) AU - Moore, Christine Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 KW - Technology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312981238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.atitle=The+Role+of+Quality+by+Design+in+Process+Analytical+Technology+%28PAT%29+and+Real+Time+Release+Testing+%28RTRT%29+Analytical+Methods&rft.au=Moore%2C+Christine&rft.aulast=Moore&rft.aufirst=Christine&rft.date=2012-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+Meeting+of+the+Israel+Analytical+Chemistry+Society+%28ISRANALYTICA+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://isranalytica.org.il/Isranalytica2012/Scientific%20Program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cloning and expression of a Trichoderma longibrachiatum beta -mannanase gene in Pichia pastoris AN - 1020848411; 16778014 AB - Trichoderma species are among the primary producers of beta -mannanase, an enzyme that catalyses the hydrolysis of beta -1, 4-glycosidic linkages in mannans and heteromannans. In this study, a Trichoderma species producing high mannanase activity was identified as Trichoderma longibrachiatum based on sequence analysis of its rDNA internal transcribed spacer region. The open reading frame of the gene encoding for beta -mannanase of T. longibrachiatum, man1 is 1,441 bp and is separated by two introns. The MAN1 amino acid sequence showed 95% identity to Trichoderma reesei beta -mannanase. Domain analysis classified MAN1 as a member of glycosyl hydrolase family 5 and detected the presence of a carbohydrate-binding domain family 1 at its C-terminus. The recombinant mannanase, rMAN1, was successfully expressed as a similar to 60 kDa extracellular recombinant protein in Pichia pastoris and was verified via western blotting analyses. The specific activity of the purified rMAN1 was 1416.18 U/mg. The optimal rMAN1 activity was recorded at 55 degree C and pH 5. The enzyme was stable with 30 min pre-incubation at temperatures ranging from 4 to 50 degree C. The enzyme was stable at pH 4 to 7 but became progressively unstable at pH values below 3 and above 8. rMAN1 had a high affinity towards locust bean gum as a substrate, with a K sub(m) value of 0.95 mg/ml. JF - African Journal of Biotechnology AU - Lim, J L AU - Bakar, FDA AU - Yusof, H M AU - Murad, AMA AD - School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, munir@ukm.my Y1 - 2012/01/24/ PY - 2012 DA - 2012 Jan 24 SP - 1705 EP - 1718 VL - 11 IS - 7 SN - 1684-5315, 1684-5315 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Western blotting KW - mannan KW - C-Terminus KW - Enzymes KW - Hydrolysis KW - Beans KW - Spacer region KW - Introns KW - Trichoderma longibrachiatum KW - Hypocrea jecorina KW - Glycosyl hydrolase KW - Pichia pastoris KW - pH effects KW - Open reading frames KW - Catalysis KW - Amino acid sequence KW - W 30925:Genetic Engineering KW - G 07800:Plants and Algae KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020848411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=African+Journal+of+Biotechnology&rft.atitle=Cloning+and+expression+of+a+Trichoderma+longibrachiatum+beta+-mannanase+gene+in+Pichia+pastoris&rft.au=Lim%2C+J+L%3BBakar%2C+FDA%3BYusof%2C+H+M%3BMurad%2C+AMA&rft.aulast=Lim&rft.aufirst=J&rft.date=2012-01-24&rft.volume=11&rft.issue=7&rft.spage=1705&rft.isbn=&rft.btitle=&rft.title=African+Journal+of+Biotechnology&rft.issn=16845315&rft_id=info:doi/10.5897%2FAJB11.2046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Temperature effects; Western blotting; mannan; C-Terminus; Enzymes; Hydrolysis; Beans; Spacer region; Introns; Glycosyl hydrolase; pH effects; Open reading frames; Amino acid sequence; Catalysis; Trichoderma longibrachiatum; Hypocrea jecorina; Pichia pastoris DO - http://dx.doi.org/10.5897/AJB11.2046 ER - TY - CPAPER T1 - Challenges in Development of Melamine Analysis in Food Contamination T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313083044; 6117527 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Krynitsky, Alexander Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Food contamination KW - melamine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313083044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Challenges+in+Development+of+Melamine+Analysis+in+Food+Contamination&rft.au=Krynitsky%2C+Alexander&rft.aulast=Krynitsky&rft.aufirst=Alexander&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Refractive Index Effects in Raman Imaging T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313072819; 6117451 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Kauffman, John AU - Mecker, Laura Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Imaging techniques KW - Refractive index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313072819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Refractive+Index+Effects+in+Raman+Imaging&rft.au=Kauffman%2C+John%3BMecker%2C+Laura&rft.aulast=Kauffman&rft.aufirst=John&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspective on Continuous Manufacturing T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313067916; 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6117530 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - McGrath, Timothy Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Food processing KW - Food plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313067728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=FSMA+and+what+is+Might+Mean+for+Domestic+and+International+Food+Processing+Plants+in+Terms+of+Changes+to+Testing+Requirements&rft.au=McGrath%2C+Timothy&rft.aulast=McGrath&rft.aufirst=Timothy&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pesticide Residue Analysis (QuEChERS, LC and GC-MS) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313067690; 6117529 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Wong, Jon Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pesticide residues UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313067690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Pesticide+Residue+Analysis+%28QuEChERS%2C+LC+and+GC-MS%29&rft.au=Wong%2C+Jon&rft.aulast=Wong&rft.aufirst=Jon&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Deep Ultraviolet Resonance Raman Spectroscopy in Application of Quality Control of Therapeutic Proteins T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313066716; 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6117367 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Woodcock, Janet Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313065155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=FDA+Brings+Science+to+the+Forefront+%28TBC%29&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2012-01-22&rft.volume=22&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2011.603394 L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - "30 Years of Chemometrics" T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313035136; 6117521 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Fry, Fred AU - Handy, Sara Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313035136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=%2230+Years+of+Chemometrics%22&rft.au=Fry%2C+Fred%3BHandy%2C+Sara&rft.aulast=Fry&rft.aufirst=Fred&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Pharma Waters & Real-Time Analysis (TBC) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313034367; 6117393 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Riley, Bryan Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313034367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Enhanced+Early+Head+Start+with+Employment+Services%3A+42-Month+Impacts+from+the+Kansas+and+Missouri+Sites+of+the+Enhanced+Services+for+the+Hard-to-Employ+Demonstration+and+Evaluation+Project.+OPRE+Report+2012-05&rft.au=Hsueh%2C+JoAnn%3BFarrell%2C+Mary+E.&rft.aulast=Hsueh&rft.aufirst=JoAnn&rft.date=2012-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integration PAT Real-time Process Monitoring and Physicochemical Characterization for Determining the Nucleation and Growth Mechanisms during a Dynamic Pharmaceutical Co-precipitation Process: A Process QbD Case Study T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313030897; 6117601 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Case studies KW - Physicochemical properties KW - Nucleation KW - Integration KW - Pharmaceuticals KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313030897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Integration+PAT+Real-time+Process+Monitoring+and+Physicochemical+Characterization+for+Determining+the+Nucleation+and+Growth+Mechanisms+during+a+Dynamic+Pharmaceutical+Co-precipitation+Process%3A+A+Process+QbD+Case+Study&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Process-sensitive Sentinel Genes as Novel Cell Culture Comparability Metrics T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313020433; 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6117424 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Brorson, Kurt Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Bioreactors KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313020255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Bioreactor+Introduction+and+Overview&rft.au=Brorson%2C+Kurt&rft.aulast=Brorson&rft.aufirst=Kurt&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - The Role of Modelling in QbD Discussions on the ICH Points to Consider - What is the role of modelling in QbD... How do we file Models... Do all models require the same amount of supporting material for filing? T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313019531; 6117414 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Chatterjee, Sharmista AU - Korakianiti, Evdokia AU - Kourti, Dora AU - Lepore, John AU - Liesum, Lorenz AU - Nasr, Moheb Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313019531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=The+Role+of+Modelling+in+QbD+Discussions+on+the+ICH+Points+to+Consider+-+What+is+the+role+of+modelling+in+QbD...+How+do+we+file+Models...+Do+all+models+require+the+same+amount+of+supporting+material+for+filing%3F&rft.au=Chatterjee%2C+Sharmista%3BKorakianiti%2C+Evdokia%3BKourti%2C+Dora%3BLepore%2C+John%3BLiesum%2C+Lorenz%3BNasr%2C+Moheb&rft.aulast=Chatterjee&rft.aufirst=Sharmista&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - ATR-TR-IR Imaging (TBA) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1313004537; 6117457 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Lanzarotta, Adam Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313004537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2012+Conference+on+Physics+of+Medical+Imaging&rft.atitle=A+mathematical+framework+for+including+various+sources+of+variability+in+a+task-based+assessment+of+digital+breast+tomosynthesis&rft.au=Park%2C+Subok%3BBadal-Soler%2C+Andreu%3BYoung%2C+Stefano%3BMyers%2C+Kyle&rft.aulast=Park&rft.aufirst=Subok&rft.date=2012-02-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Conference+on+Physics+of+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluation of Process Models with Monte Carolo Methods T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993443; 6117552 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Kauffman, John AU - Chatterjee, Sharmista AU - Geoffroy, Jean-Marie Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluation+of+Process+Models+with+Monte+Carolo+Methods&rft.au=Kauffman%2C+John%3BChatterjee%2C+Sharmista%3BGeoffroy%2C+Jean-Marie&rft.aulast=Kauffman&rft.aufirst=John&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - CDER PAT Work (TBA) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993282; 6117430 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Read, Erik Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.atitle=Isolation+and+structural+characterization+of+two+tadalafil+analogs+found+in+dietary+supplements&rft.au=Toomey%2C+Valerie+M%3BLitzau%2C+Jonathan+J%3BFlurer%2C+Cheryl+L&rft.aulast=Toomey&rft.aufirst=Valerie&rft.date=2012-02-05&rft.volume=59&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+and+Biomedical+Analysis&rft.issn=07317085&rft_id=info:doi/10.1016%2Fj.jpba.2011.09.038 L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory Perspectives on Risk Management Across the Lifecycle T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312993092; 6117386 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Friedman, Rick Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Life cycle KW - Risk management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312993092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Regulatory+Perspectives+on+Risk+Management+Across+the+Lifecycle&rft.au=Friedman%2C+Rick&rft.aulast=Friedman&rft.aufirst=Rick&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - PAT/RTR: Regulatory Perspective (TBC) T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312992971; 6117383 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Shah, Vibhakar Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=PAT%2FRTR%3A+Regulatory+Perspective+%28TBC%29&rft.au=Shah%2C+Vibhakar&rft.aulast=Shah&rft.aufirst=Vibhakar&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Regulatory Perspective on NIR Method Robustness T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312969717; 6117589 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Tang, Yubing Tang Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Pharmaceuticals KW - Manufacturing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312969717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=A+Regulatory+Perspective+on+NIR+Method+Robustness&rft.au=Tang%2C+Yubing+Tang&rft.aulast=Tang&rft.aufirst=Yubing&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Evaluating the Sensitivity of Library-Based Spectral Correlation Methods and Their Transferability Between Different Spectrometers T2 - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AN - 1312951013; 6117558 JF - 26th International Forum and Exhibition on Process Analytical Technology (IFPAC 2012) AU - Rodriguez, Jason AU - Buhse, Lucinda AU - Westenberger, Benjamin AU - Kauffman, John Y1 - 2012/01/22/ PY - 2012 DA - 2012 Jan 22 KW - Sensitivity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312951013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.atitle=Evaluating+the+Sensitivity+of+Library-Based+Spectral+Correlation+Methods+and+Their+Transferability+Between+Different+Spectrometers&rft.au=Rodriguez%2C+Jason%3BBuhse%2C+Lucinda%3BWestenberger%2C+Benjamin%3BKauffman%2C+John&rft.aulast=Rodriguez&rft.aufirst=Jason&rft.date=2012-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Forum+and+Exhibition+on+Process+Analytical+Technology+%28IFPAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ifpac.com/cgi-bin/IFPACProgram2012.pl LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Is toxicogenomics a more reliable and sensitive biomarker than conventional indicators from rats to predict drug-induced liver injury in humans? AN - 916518766; 22122743 AB - Around 40% of drug-induced liver injury (DILI) cases are not detected in preclinical studies using the conventional indicators. It has been hypothesized that genomic biomarkers will be more sensitive than conventional markers in detecting human hepatotoxicity signals in preclinical studies. For example, it has been hypothesized and demonstrated in some cases that (1) genomic biomarkers from the rat liver can discriminate drug candidates that have a greater or lesser potential to cause DILI in susceptible patients despite no conventional indicators of liver toxicity being observed in preclinical studies, and (2) more sensitive biomarkers for early detection of DILI can be derived from a "subtoxic dose" at which the injury in the liver occurs at the molecular but not the phenotypic level. With a public TGx data set derived from short-term in vivo studies using rats, we divided drugs exhibiting human hepatotoxicity into three groups according to whether elevated alanine aminotransferase (ALT) or total bilirubin (TBL) were observed in the treated rats: (A) The elevation was observed in the treated rats, (B) no elevation was observed for all of the treated rats, and (C) no elevation could be observed at a lower dose and shorter duration but occur when a higher or longer treatment was applied. A control group (D) was comprised of drugs known not to cause human hepatotoxicity and for which no rats exhibited elevated ALT or TBL. We developed classifiers for groups A, B, and C against group D and found that the gene signature from scenario A could achieve 83% accuracy for human hepatotoxicity potential of drugs in a leave-one-compound-out cross-validation process, much higher than scenarios B (average 45%) and C (61%). Furthermore, the signature derived from scenario A exhibited relevance to hepatotoxicity in a pathway-based analysis and performed well on two independent public TGx data sets using different chemical treatments and profiled with different microarray platforms. Our study implied that the human hepatotoxicity potential of a drug can be reasonably assessed using TGx analysis of short-term in vivo studies only if it produces significant elevation of ALT or TBL in the treated rats. The study further revealed that the value of "sensitive" biomarkers derived from scenario C was not promising as expected for DILI assessment using the reported TGx design. The study will facilitate further research to understand the role of genomic biomarkers from rats for assessing human hepatotoxicity. JF - Chemical research in toxicology AU - Zhang, Min AU - Chen, Minjun AU - Tong, Weida AD - Center of Excellence for Bioinformatics, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2012/01/13/ PY - 2012 DA - 2012 Jan 13 SP - 122 EP - 129 VL - 25 IS - 1 KW - Biomarkers KW - 0 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Toxicogenetics KW - Disease Models, Animal KW - Biomarkers -- metabolism KW - Models, Biological KW - Bilirubin -- metabolism KW - Chemical and Drug Induced Liver Injury -- genetics KW - Alanine Transaminase -- metabolism KW - Gene Expression KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916518766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Is+toxicogenomics+a+more+reliable+and+sensitive+biomarker+than+conventional+indicators+from+rats+to+predict+drug-induced+liver+injury+in+humans%3F&rft.au=Zhang%2C+Min%3BChen%2C+Minjun%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Min&rft.date=2012-01-13&rft.volume=25&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200320e LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-01 N1 - Date created - 2012-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200320e ER - TY - JOUR T1 - A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods AN - 1635018332; 16257811 AB - A new analytical method was developed to determine the presence of six (6) compounds with the potential to be used in economic adulteration to enhance the nitrogen content in milk products and bulk proteins. Residues were extracted from the matrix with 2% formic acid, after which acetonitrile (ACN) was added to induce precipitation of the proteins. Extracts were analyzed by liquid chromatography using a ZIC-HILIC column with tandem mass spectrometry (LC-MS/MS) using electrospray ionization (ESI). Single-laboratory method validation data was collected in six matrices fortified at concentrations down to 1.0 mu g/g (ppm). Average recoveries and average relative standard deviations (RSD) using spiked matrix calibration standard curves were the following: cyromazine (CY) 95.9% (7.5% RSD), dicyandiamide (DC) 98.1% (5.6% RSD), urea 102.5% (8.6% RSD), biuret (BU) 97.2% (6.6% RSD), triuret (TU) 97.7% (5.7% RSD), and amidinourea (AU) 93.4% (7.4% RSD). This method provides a rapid and effective approach to proactively combat economically motivated adulteration in protein-containing products. JF - Journal of Chromatography A AU - MacMahon, Shaun AU - Begley, Timothy H AU - Diachenko, Gregory W AU - Stromgren, Selen A AD - United States Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA, shaun.macmahon@fda.hhs.gov Y1 - 2012/01/13/ PY - 2012 DA - 2012 Jan 13 SP - 101 EP - 107 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1220 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Melamine KW - Economic adulteration KW - Mass spectrometry KW - Protein KW - Molecular structure KW - Mass Spectrometry KW - Ureas KW - Chromatographic techniques KW - Precipitation KW - Mass spectroscopy KW - Methodology KW - Foods KW - Calibrations KW - Standard Deviation KW - Proteins KW - Standards KW - Nitrogen KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635018332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=A+liquid+chromatography-tandem+mass+spectrometry+method+for+the+detection+of+economically+motivated+adulteration+in+protein-containing+foods&rft.au=MacMahon%2C+Shaun%3BBegley%2C+Timothy+H%3BDiachenko%2C+Gregory+W%3BStromgren%2C+Selen+A&rft.aulast=MacMahon&rft.aufirst=Shaun&rft.date=2012-01-13&rft.volume=1220&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.11.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Molecular structure; Chromatographic techniques; Mass spectroscopy; Methodology; Mass Spectrometry; Foods; Standard Deviation; Calibrations; Ureas; Proteins; Standards; Precipitation; Nitrogen DO - http://dx.doi.org/10.1016/j.chroma.2011.11.066 ER - TY - JOUR T1 - FDA Limits Use Of Cephalosporin In Food Animals AN - 914479416 AB - USDA's Food and Drug Administration (FDA) this week prohibited certain uses of cephalosporin antibiotics in animals. The move, FDA says, is aimed at preventing antibiotic resistance and preserving the drug's effectiveness for treating human diseases. The new FDA order, which takes effect April 5, applies to off-label or unapproved use of cephalosporins in major food-producing animals: cattle, swine, chickens, and turkeys. Mike Apley, DVM and a professor in Kansas State University's Department of Veterinary Clinical Sciences, as well as director of the PharmCATS Bioanalytical Laboratory, characterizes the change as "moderate." "For beef cattle, what it does is remove the ability to alter regimen but we can still use it for label application and other applications other than on the label when we meet the AMDUCA requirements, just as always. Basically what it does is stipulate that we can't alter the dose regimen and we can't use these products off label for the prevention of disease. We're still trying to get our mind around what fits that definition. Does that include the use of Ceftiofur (marketed by Pfizer as NaxcelTM, ExcenelTM and ExcedeTM) following a surgery? That might be one place where we will have an alteration on use. In addition, the rule stipulates that we can't use human cephalosporins in cattle production, which would be a rare occurrence in my opinion already," he says. JF - Beef AU - FDA release AU - Roybal, Joe Y1 - 2012/01/06/ PY - 2012 DA - 2012 Jan 06 CY - Minneapolis PB - Penton Media, Inc., Penton Business Media, Inc. SN - 00057738 KW - Agriculture--Poultry And Livestock UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914479416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabitrade&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Beef&rft.atitle=FDA+Limits+Use+Of+Cephalosporin+In+Food+Animals&rft.au=FDA+release%3BRoybal%2C+Joe&rft.aulast=FDA+release&rft.aufirst=&rft.date=2012-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Beef&rft.issn=00057738&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright Penton Business Media, Inc. and Penton Media, Inc. Jan 6, 2012 N1 - Last updated - 2012-01-07 ER - TY - JOUR T1 - Pre- and Postnatal Polychlorinated Biphenyl Concentrations and Longitudinal Measures of Thymus Volume in Infants AN - 1017976399; 16725627 AB - Background: Previously, we reported an association between higher maternal polychlorinated biphenyl (PCB) concentrations and smaller thymus volume in newborns in a birth cohort residing in eastern Slovakia. Objective: In the present report we address whether thymus volume at later ages is influenced by prenatal and early postnatal PCB exposure. Methods: At the time of delivery, 1,134 mother-infant pairs were enrolled. Maternal and 6- and 16-month infant blood samples were collected and analyzed for 15 PCB congeners. Thymus volume was measured in infants shortly after birth and at ages 6 and 16 months using ultrasonography. Results: Higher maternal PCB concentration was associated with reduced thymus volume at birth [a 0.21 SD reduction in thymus volume for an increase in total maternal PCB concentration from the 10th to the 90th percentile; 95% confidence interval (CI): -0.37, -0.05], whereas maternal PCB concentration was not predictive of 6- and 16-month thymus volume. Six-month infant PCB concentration was associated with a 0.40 SD decrease in 6-month thymus volume (95% CI: -0.76, -0.04). There was also some suggestion that thymus volume at 16 months was positively associated with concurrent infant PCB concentration. Conclusions: The potential adverse effects of in utero PCB exposure on thymic development may extend beyond the neonatal period. Results from this highly exposed cohort provide suggestive evidence that postnatal PCB concentrations may be influential, but a smaller set of 6-month PCB measurements limited statistical power at that time point. Implications regarding impaired immunologic maturation or long-term clinical implications remain to be determined. JF - Environmental Health Perspectives AU - Jusko, Todd A AU - Sonneborn, Dean AU - Palkovicova, Lubica AU - Kocan, Anton AU - Drobna, Beata AU - Trnovec, Tomas AU - Hertz-Picciotto, Irva AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2012/01/03/ PY - 2012 DA - 2012 Jan 03 SP - 595 EP - 600 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 4 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Environment Abstracts KW - atrophy KW - cohort KW - epidemiology KW - immune KW - Roma KW - T cell KW - Age KW - Slovakia KW - Statistics KW - Prenatal experience KW - Thymus KW - Intrauterine exposure KW - Ultrasonography KW - prenatal experience KW - Bioaccumulation KW - polychlorinated biphenyls KW - Congeners KW - Neonates KW - PCB compounds KW - PCB KW - Side effects KW - Infants KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017976399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Pre-+and+Postnatal+Polychlorinated+Biphenyl+Concentrations+and+Longitudinal+Measures+of+Thymus+Volume+in+Infants&rft.au=Jusko%2C+Todd+A%3BSonneborn%2C+Dean%3BPalkovicova%2C+Lubica%3BKocan%2C+Anton%3BDrobna%2C+Beata%3BTrnovec%2C+Tomas%3BHertz-Picciotto%2C+Irva&rft.aulast=Jusko&rft.aufirst=Todd&rft.date=2012-01-03&rft.volume=120&rft.issue=4&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1104229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Prenatal experience; Statistics; polychlorinated biphenyls; Thymus; Congeners; Intrauterine exposure; Neonates; Ultrasonography; Side effects; PCB; Infants; prenatal experience; Bioaccumulation; PCB compounds; Slovakia DO - http://dx.doi.org/10.1289/ehp.1104229 ER - TY - JOUR T1 - Intelligence and past use of recreational drugs AN - 964270629; 201207645 AB - One motivation for trying recreational drugs is the desire for novel experiences. More intelligent people tend to value novelty more highly and may therefore be more likely to have tried recreational drugs. Using data from a national survey, it is shown that intelligence tends to be positively related to the probabilities of having tried alcohol, marijuana, cocaine and several other recreational drugs. Evidence is also presented that those relationships typically disappear or change sign at high levels of intelligence. These patterns persist after accounting for a wide range of personal characteristics. [Copyright Elsevier Inc.] JF - Intelligence AU - Wilmoth, Daniel R AD - Cornell University, Department of Economics, Uris Hall 4th Floor, Ithaca, NY 14853, USA daniel.wilmoth@fda.hhs.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 15 EP - 22 PB - Elsevier, Amsterdam The Netherlands VL - 40 IS - 1 SN - 0160-2896, 0160-2896 KW - Intelligence Alcohol Drugs KW - Desire KW - Intelligence KW - Motivation KW - Cannabis KW - Accounting KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964270629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Intelligence&rft.atitle=Intelligence+and+past+use+of+recreational+drugs&rft.au=Wilmoth%2C+Daniel+R&rft.aulast=Wilmoth&rft.aufirst=Daniel&rft.date=2012-01-01&rft.volume=40&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Intelligence&rft.issn=01602896&rft_id=info:doi/10.1016%2Fj.intell.2011.10.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NTLLDT N1 - SubjectsTermNotLitGenreText - Intelligence; Substance abuse; Cannabis; Accounting; Desire; Motivation DO - http://dx.doi.org/10.1016/j.intell.2011.10.005 ER - TY - JOUR T1 - Let The Data Be Our Guide: Trends And Tools For Research On Health Care Utilization AN - 964269352; 201206403 AB - Although consensus has yet to emerge about the appropriate framework and acceptable measures of efficiency, the AHRQ's HCUP databases and its annual quality and disparities reports are tools that researchers and policy analysts can use to understand healthcare inefficiency on a broad scale and then drill down into specifics. Clinicians can use them to understand how their practice patterns compare with national trends. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Clancy, Carolyn M AD - Agency for Healthcare Research and Quality (AHRQ), Rockville, MD USA cathy.tokarski@ahrq.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 19 EP - 23 PB - John Wiley, Chichester UK VL - 21 IS - 1 SN - 1057-9230, 1057-9230 KW - Databases KW - Health care KW - Health inequalities KW - Medical research KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964269352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Let+The+Data+Be+Our+Guide%3A+Trends+And+Tools+For+Research+On+Health+Care+Utilization&rft.au=Clancy%2C+Carolyn+M&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2012-01-01&rft.volume=21&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1809 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Health inequalities; Medical research; Databases; Helpseeking; Health care DO - http://dx.doi.org/10.1002/hec.1809 ER - TY - JOUR T1 - Emotional Relationships in Mothers and Infants: Culture-Common and Community-Specific Characteristics of Dyads From Rural and Metropolitan Settings in Argentina, Italy, and the United States AN - 964267968; 201206295 AB - This study uses country and regional contrasts to examine culture-common and community-specific variation in mother-infant emotional relationships. Altogether, 220 Argentine, Italian, and U.S. American mothers and their daughters and sons, living in rural and metropolitan settings, were observed at home at infant age 5 months. Both variable- and person-centered perspectives of dyadic emotional relationships were analyzed. Supporting the notion that adequate emotional relationships are a critical and culture-common characteristic of human infant development, across all samples most dyads scored in the adaptive range in terms of emotional relationships. Giving evidence of community-specific characteristics, Italian mothers were more sensitive, and Italian infants more responsive, than Argentine and U.S. mothers and infants; in addition, rural mothers were more intrusive than metropolitan mothers and rural dyads more likely than expected to be classified as midrange in emotional relationships and less likely to be classified as high in emotional relationships. Adaptive emotional relationships appear to be a culture-common characteristic of mother-infant dyads near the beginning of life, but this relational construct is moderated by a community-specific (country and regional) context. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Journal of Cross-Cultural Psychology AU - Bornstein, Marc H AU - Putnick, Diane L AU - Suwalsky, Joan T D AU - Venuti, Paola AU - de Falco, Simona AU - de Galperin, Celia Zingman AU - Gini, Motti AU - Tichovolsky, Marianne Heslington AD - Child & Family Research Section, National Institute of Child Health & Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 171 EP - 197 PB - Sage Publications, Thousand Oaks VL - 43 IS - 2 SN - 0022-0221, 0022-0221 KW - cultural psychology child/adolescent development social development KW - Sons KW - Daughters KW - Mothers KW - Rural communities KW - Italy KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964267968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Emotional+Relationships+in+Mothers+and+Infants%3A+Culture-Common+and+Community-Specific+Characteristics+of+Dyads+From+Rural+and+Metropolitan+Settings+in+Argentina%2C+Italy%2C+and+the+United+States&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BSuwalsky%2C+Joan+T+D%3BVenuti%2C+Paola%3Bde+Falco%2C+Simona%3Bde+Galperin%2C+Celia+Zingman%3BGini%2C+Motti%3BTichovolsky%2C+Marianne+Heslington&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2012-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2012+Keystone+Symposia+Meeting+on+Complex+Traits%3A+Genomics+and+Computational+Approaches&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - Mothers; Infants; Rural communities; Italy; Daughters; Sons DO - http://dx.doi.org/10.1177/0022022110388563 ER - TY - JOUR T1 - Evaluating portable infrared spectrometers for measuring the silica content of coal dust AN - 954647774; 16404346 AB - Miners face a variety of respiratory hazards while on the job, including exposure to silica dust which can lead to silicosis, a potentially fatal lung disease. Currently, field-collected filter samples of silica are sent for laboratory analysis and the results take weeks to be reported. Since the mining workplace is constantly moving into new and often different geological strata with changing silica levels, more timely data on silica levels in mining workplaces could help reduce exposures. Improvements in infrared (IR) spectroscopy open the prospect for end-of-shift silica measurements at mine sites. Two field-portable IR spectrometers were evaluated for their ability to quantify the mass of silica on filter samples loaded with known amounts of either silica or silica-bearing coal dust (silica content ranging from 10-200 mu g/filter). Analyses included a scheme to correct for the presence of kaolin, which is a confounder for IR analysis of silica. IR measurements of the samples were compared to parallel measurements derived using the laboratory-based U.S. Mine Safety and Health Administration P7 analytical method. Linear correlations between Fourier transform infrared (FTIR) and P7 data yielded slopes in the range of 0.90-0.97 with minimal bias. Data from a variable filter array spectrometer did not correlate as well, mainly due to poor wavelength resolution compared to the FTIR instrument. This work has shown that FTIR spectrometry has the potential to reasonably estimate the silica exposure of miners if employed in an end-of-shift method. JF - Journal of Environmental Monitoring AU - Miller, AL AU - Drake, P L AU - Murphy, N C AU - Noll, J D AU - Volkwein, J C AD - National Institute for Occupational Safety and Health, 315 E. Montgomery Ave, Spokane, WA, 99207, USA, ALMiller@cdc.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 48 EP - 55 VL - 14 IS - 1 SN - 1464-0325, 1464-0325 KW - Environment Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Filters KW - USA KW - Fourier transforms KW - Safety regulations KW - silica KW - Occupational safety KW - Coal KW - Mining KW - Dust KW - Spectrometry KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954647774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Evaluating+portable+infrared+spectrometers+for+measuring+the+silica+content+of+coal+dust&rft.au=Miller%2C+AL%3BDrake%2C+P+L%3BMurphy%2C+N+C%3BNoll%2C+J+D%3BVolkwein%2C+J+C&rft.aulast=Miller&rft.aufirst=AL&rft.date=2012-01-01&rft.volume=127&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Engineering+Geology&rft.issn=00137952&rft_id=info:doi/10.1016%2Fj.enggeo.2012.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Filters; Safety regulations; Fourier transforms; silica; Occupational safety; Mining; Coal; Dust; Spectrometry; USA DO - http://dx.doi.org/10.1039/c1em10678c ER - TY - JOUR T1 - Establishing the carcinogenic risk of immunomodulatory drugs. AN - 934266552; 22105649 AB - The first effective immunosuppressive drug (ISD) was azathioprine, approved in 1968. Early experience with this drug suggested that patients might have an excess risk of tumors including lymphoma and skin tumors. Comparison among various registries has shown that the cumulative risk of tumors increases over time. The risk is additionally increased by the more intense immunosuppressive regimens needed for lung or heart-lung transplants. The link between immunosuppression and tumorigenesis was further reinforced by the high concordance of tumor types between transplant and HIV patients. The role of the immune system in tumor defense includes both direct tumor surveillance and immunity against oncogenic viruses. In transplant patients, at least two-thirds of the lymphomas are Epstein-Barr virus (EBV)-positive. Existing methods of testing for carcinogenicity are not considered adequate to identify the hazard of tumorigenesis due to these drugs. Research is ongoing in Food and Drug Administration laboratories and at collaborators' laboratories to evaluate experimental systems that may have the ability to adequately identify this class of hazard. Initial work is on various model systems similar to EBV. These include the MHV-68 mouse model, lymphocryptovirus (LCV-1) in the cynomolgus monkey, and preliminary work with mice with humanized immune systems using EBV directly. JF - Toxicologic pathology AU - Weaver, James L AD - Division of Drug Safety Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. james.weaver@fda.hhs.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 267 EP - 271 VL - 40 IS - 2 KW - Immunologic Factors KW - 0 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Drug Evaluation -- methods KW - Immunologic Factors -- immunology KW - Neoplasms -- chemically induced KW - Neoplasms -- immunology KW - Immunologic Factors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/934266552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Establishing+the+carcinogenic+risk+of+immunomodulatory+drugs.&rft.au=Weaver%2C+James+L&rft.aulast=Weaver&rft.aufirst=James&rft.date=2012-01-01&rft.volume=40&rft.issue=2&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623311427711 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-08-30 N1 - Date created - 2012-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623311427711 ER - TY - JOUR T1 - Occupational Injuries, Illnesses, and Fatalities Among Workers in the Services Sector Industries 2003 to 2007 AN - 926891586; 16292450 AB - Objective: Provide descriptive statistics and discuss priorities for injury and fatality risks among services sector workers. Methods: Bureau of Labor Statistics Survey of Occupational Injuries and Illnesses and Census of Fatal Occupational Injuries data for 2003 to 2007 were analyzed to identify occupational injury and fatality risks for services sector industry groups. Results: Many services sector industry groups experienced, on average, greater than one occupational fatality per week, and survey of occupational injuries and illnesses days-away-from-work rates in excess of those for all US workers. Overall, transportation incidents and homicides are leading factors contributing to fatalities. Conclusions: These results indicate the need for adoption of safety and health prevention practices in numerous industry groups. For groups that experience elevated injury and fatality rates, priorities for research and intervention can be identified through these data. JF - Journal of Occupational and Environmental Medicine AU - Utterback, D F AU - Charles, LE AU - Schnorr, T M AU - Tiesman, H M AU - Storey, E AU - Vossenas, P AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, dutterback@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 31 EP - 41 VL - 54 IS - 1 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Mortality KW - Occupational safety KW - Transportation KW - census KW - homicide KW - intervention KW - prevention KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Injuries%2C+Illnesses%2C+and+Fatalities+Among+Workers+in+the+Services+Sector+Industries+2003+to+2007&rft.au=Utterback%2C+D+F%3BCharles%2C+LE%3BSchnorr%2C+T+M%3BTiesman%2C+H+M%3BStorey%2C+E%3BVossenas%2C+P&rft.aulast=Utterback&rft.aufirst=D&rft.date=2012-01-01&rft.volume=55&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - census; Mortality; homicide; Transportation; Injuries; intervention; Occupational safety; prevention DO - http://dx.doi.org/10.1097/JOM.0b013e3182398e36 ER - TY - JOUR T1 - Association of overtime work with cellular immune markers among healthy daytime white-collar employees AN - 920803642; 16281334 AB - Objective Even though overtime work has been suspected to be a risk factor for ill health, little research has been done to determine the underlying immunological mechanisms. This study investigated the association between overtime work and cellular immunity among Japanese white-collar workers. Methods A total of 306 healthy, full-time, non-shift, daytime employees (165 men and 141 women), aged 22-69 (mean 36) years, provided a blood sample for the measurement of circulating immune [natural killer (NK), B, and T] cells and NK cell cytotoxicity (NKCC) and completed a questionnaire survey including overtime/month. Blood samples were collected between 09.00-11.00 hours during working days and participants completed the questionnaire within the two weeks prior to the blood sampling. Stepwise linear regression analyses controlling for confounders were carried out to examine the relationship between overtime work and immune markers. Results Overtime work was mainly related to short sleep duration, increased weight, and reduced job satisfaction, and it was more prevalent among men than women and among younger and married employees. Amount of overtime was inversely associated with NK (CD3-CD56+) cell counts (ss=-0.145; P =0.032) but was not associated with NKCC, NKCC/NK cell ratio, or T or B cells. Conclusions The NK cell is a lymphocyte that possesses killer activity against tumor and virus-infected cells and constitutes a major component of the innate immune system. A decrease of NK cell counts from overtime work suggests a dampened innate immune defense. However, the finding needs to be further validated with a well-designed study using objective overtime measures. JF - Scandinavian Journal of Work, Environment & Health AU - Nakata, A AU - Takahashi, M AU - Irie, M AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-C24, Cincinnati, OH 45226, USA, cji5@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 56 EP - 64 VL - 38 IS - 1 SN - 0355-3140, 0355-3140 KW - Immunology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Inventories KW - immune system KW - Lymphocytes B KW - Immune system KW - Natural killer cells KW - tumors KW - Lymphocytes KW - Tumors KW - Cytotoxicity KW - Daytime KW - Immunity (cell-mediated) KW - Sleep KW - Risk factors KW - Lymphocytes T KW - Regression analysis KW - Sampling KW - Japan KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920803642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Association+of+overtime+work+with+cellular+immune+markers+among+healthy+daytime+white-collar+employees&rft.au=Nakata%2C+A%3BTakahashi%2C+M%3BIrie%2C+M&rft.aulast=Nakata&rft.aufirst=A&rft.date=2012-01-01&rft.volume=38&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=00956562&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Inventories; Lymphocytes B; Immune system; Natural killer cells; Tumors; Cytotoxicity; Daytime; Immunity (cell-mediated); Risk factors; Sleep; Regression analysis; Lymphocytes T; Sampling; immune system; tumors; Lymphocytes; Japan DO - http://dx.doi.org/10.5271/sjweh.3183 ER - TY - JOUR T1 - Improvement of a mine fire simulation program - incorporation of smoke rollback into MFIRE 3.0 AN - 920792575; 16209844 AB - Smoke rollback is a dangerous threat to miners and firefighters in an underground mine fire. The ability to predict smoke rollback can greatly improve the chances for safe miner evacuation and mine fire control and firefighting. A modified semi-empirical equation based on large-scale experiments conducted by the National Institute for Occupational Safety and Health (NIOSH) was developed to quantify smoke rollback during an underground mine fire. The equation was incorporated into a mine fire simulation program (MFIRE 3.0) to allow the user to predict the occurrence of smoke rollback and calculate the smoke rollback distance. This article describes the development of the equation and compares the experimental results with those predicted by MFIRE 3.0. The results indicate that the improved MFIRE 3.0 is capable of determining smoke rollback in a fire entry, not only to provide early warning for smoke rollback but also to verify the effectiveness of smoke rollback control efforts. JF - Journal of Fire Sciences AU - Zhou, Lihong AU - Smith, Alex C AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, PA, itn2@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 29 EP - 39 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 30 IS - 1 SN - 0734-9041, 0734-9041 KW - Health & Safety Science Abstracts KW - coal mine fire KW - mine fire simulation KW - smoke rollback KW - Smoke KW - Fires KW - firefighter services KW - Occupational safety KW - Simulation KW - Mining KW - Mines KW - evacuation KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920792575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fire+Sciences&rft.atitle=Improvement+of+a+mine+fire+simulation+program+-+incorporation+of+smoke+rollback+into+MFIRE+3.0&rft.au=Zhou%2C+Lihong%3BSmith%2C+Alex+C&rft.aulast=Zhou&rft.aufirst=Lihong&rft.date=2012-01-01&rft.volume=30&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fire+Sciences&rft.issn=07349041&rft_id=info:doi/10.1177%2F0734904111418483 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Number of references - 17 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Smoke; Fires; firefighter services; Occupational safety; Simulation; Mining; Mines; evacuation DO - http://dx.doi.org/10.1177/0734904111418483 ER - TY - JOUR T1 - Molecular characterization of strains of fluoroquinolone-resistant Salmonella enterica serovar Schwarzengrund carrying multidrug resistance isolated from imported foods AN - 920788524; 16180635 AB - Objectives To determine the fluoroquinolone resistance determinants in Salmonella enterica serovar Schwarzengrund from imported foods. Methods Antibiotic susceptibility of Salmonella Schwarzengrund to 16 antibiotics was examined using disc agar diffusion and Etest. Quinolone resistance determinants were examined by sequence analysis of gyrA, gyrB, parC and parE, PCR amplification of qnrA, qnrB and qnrS, and expression of acrB, ramA, marA, soxS and rob using quantitative RT-PCR. The contribution of efflux pump activities to antibiotic resistance was determined by the addition of carbonyl cyanide m-chlorophenylhydrazone (CCCP). The effect of ramR deletion on ciprofloxacin resistance was determined by complementing with wild-type ramR. Results Salmonella strains 30 and 487 were susceptible to ciprofloxacin and had a single mutation in gyrA as compared with strain 75, which was highly resistant to ciprofloxacin and had a double mutation in gyrA. Increased expression of ramA was associated with high resistance to ciprofloxacin. Strain 75 had a deletion of 315 bp in the ramR gene, which regulates ramA expression. Overexpression of ramA was possibly related to a loss of ramR. Introduction of ramR decreased the MIC of ciprofloxacin from 48 to 24 mg/L. The addition of CCCP did not reduce antibiotic resistance. To our knowledge, this study reports for the first time the natural deletion of ramR in Salmonella Schwarzengrund. Conclusions This study indicates that fluoroquinolone-resistant Salmonella are prevalent in imported food. Double mutations in gyrA and a loss of ramR were associated with high-level quinolone resistance in multidrug-resistant Salmonella Schwarzengrund strain 75. JF - Journal of Antimicrobial Chemotherapy AU - Akiyama, Tatsuya AU - Khan, Ashraf A AD - Microbiology Division, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA, ashraf.khan@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 101 EP - 110 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 67 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Fluoroquinolones KW - Drug resistance KW - Food KW - Quinolones KW - DNA topoisomerase KW - Antibiotics KW - Minimum inhibitory concentration KW - DNA topoisomerase IV KW - Ciprofloxacin KW - Gene deletion KW - Cyanide KW - Salmonella enterica KW - Polymerase chain reaction KW - Diffusion KW - Multidrug resistance KW - Mutation KW - carbonyls KW - Antibiotic resistance KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920788524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Molecular+characterization+of+strains+of+fluoroquinolone-resistant+Salmonella+enterica+serovar+Schwarzengrund+carrying+multidrug+resistance+isolated+from+imported+foods&rft.au=Akiyama%2C+Tatsuya%3BKhan%2C+Ashraf+A&rft.aulast=Akiyama&rft.aufirst=Tatsuya&rft.date=2012-01-01&rft.volume=67&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkr414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Last updated - 2012-04-06 N1 - SubjectsTermNotLitGenreText - Agar; Fluoroquinolones; Food; Drug resistance; Quinolones; DNA topoisomerase; Antibiotics; Minimum inhibitory concentration; DNA topoisomerase IV; Ciprofloxacin; Gene deletion; Cyanide; Polymerase chain reaction; Multidrug resistance; Diffusion; carbonyls; Mutation; Antibiotic resistance; Salmonella enterica DO - http://dx.doi.org/10.1093/jac/dkr414 ER - TY - JOUR T1 - RNA polymerase beta subunit (rpoB) gene and the 16S-23S rRNA intergenic transcribed spacer region (ITS) as complementary molecular markers in addition to the 16S rRNA gene for phylogenetic analysis and identification of the species of the family Mycoplasmataceae AN - 918054948; 16181184 AB - Conventional classification of the species in the family Mycoplasmataceae is mainly based on phenotypic criteria, which are complicated, can be difficult to measure, and have the potential to be hampered by phenotypic deviations among the isolates. The number of biochemical reactions suitable for phenotypic characterization of the Mycoplasmataceae is also very limited and therefore the strategy for the final identification of the Mycoplasmataceae species is based on comparative serological results. However, serological testing of the Mycoplasmataceae species requires a performance panel of hyperimmune sera which contains anti-serum to each known species of the family, a high level of technical expertise, and can only be properly performed by mycoplasma-reference laboratories. In addition, the existence of uncultivated and fastidious Mycoplasmataceae species/isolates in clinical materials significantly complicates, or even makes impossible, the application of conventional bacteriological tests. The analysis of available genetic markers is an additional approach for the primary identification and phylogenetic classification of cultivable species and uncultivable or fastidious organisms in standard microbiological laboratories. The partial nucleotide sequences of the RNA polymerase beta -subunit gene (rpoB) and the 16S-23S rRNA intergenic transcribed spacer (ITS) were determined for all known type strains and the available non-type strains of the Mycoplasmataceae species. In addition to the available 16S rRNA gene data, the ITS and rpoB sequences were used to infer phylogenetic relationships among these species and to enable identification of the Mycoplasmataceae isolates to the species level. The comparison of the ITS and rpoB phylogenetic trees with the 16S rRNA reference phylogenetic tree revealed a similar clustering patterns for the Mycoplasmataceae species, with minor discrepancies for a few species that demonstrated higher divergence of their ITS and rpoB in comparison to their neighbor species. Overall, our results demonstrated that the ITS and rpoB gene could be useful complementary phylogenetic markers to infer phylogenetic relationships among the Mycoplasmataceae species and provide useful background information for the choice of appropriate metabolic and serological tests for the final classification of isolates. In summary, three-target sequence analysis, which includes the ITS, rpoB, and 16S rRNA genes, was demonstrated to be a reliable and useful taxonomic tool for the species differentiation within the family Mycoplasmataceae based on their phylogenetic relatedness and pairwise sequence similarities. We believe that this approach might also become a valuable tool for routine analysis and primary identification of new isolates in medical and veterinary microbiological laboratories. JF - Molecular Phylogenetics and Evolution AU - Volokhov, Dmitriy V AU - Simonyan, Vahan AU - Davidson, Maureen K AU - Chizhikov, Vladimir E AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, MD 20852, United States, dmitriy.volokhov@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 515 EP - 528 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 62 IS - 1 SN - 1055-7903, 1055-7903 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Mycoplasmas KW - Phylogeny KW - Bacteria KW - rpoB KW - 16S rRNA KW - rRNA KW - Differentiation KW - DNA-directed RNA polymerase KW - Spacer region KW - Data processing KW - Classification KW - Genetic markers KW - Serological tests KW - rRNA 16S KW - RpoB protein KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918054948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Phylogenetics+and+Evolution&rft.atitle=Lactobacillus+acidophilus+and+Lactobacillus+reuteri+modulate+cytokine+responses+in+gnotobiotic+pigs+infected+with+human+rotavirus.&rft.au=Azevedo%2C+M+S+P%3BZhang%2C+W%3BWen%2C+K%3BGonzalez%2C+A+M%3BSaif%2C+L+J%3BYousef%2C+A+E%3BYuan%2C+L&rft.aulast=Azevedo&rft.aufirst=M+S&rft.date=2012-03-01&rft.volume=3&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Beneficial+microbes&rft.issn=1876-2891&rft_id=info:doi/10.3920%2FBM2011.0041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Phylogeny; Differentiation; rRNA; Spacer region; DNA-directed RNA polymerase; Data processing; Classification; Genetic markers; Serological tests; rRNA 16S; RpoB protein DO - http://dx.doi.org/10.1016/j.ympev.2011.11.002 ER - TY - JOUR T1 - Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood. AN - 916145249; 22017681 AB - Puberty is an important transition that enables reproduction of mammalian species. Precocious puberty, specifically early thelarche (the appearance of breast "buds"), in girls of multiple ethnic backgrounds is a major health problem in the United States and other countries. The cause for a continued decrease in the age of breast development in girls is unknown, but environmental factors likely play a major role. Laboratory and epidemiological studies have identified several individual environmental factors that affect breast development, but further progress is needed. Current research needs include increased attention to and recording of prenatal and neonatal environmental exposures, testing of marketed chemicals for effects on the mammary gland, and understanding of the mammary gland-specific mechanisms that are altered by chemicals. Such research is required to halt the increasing trend toward puberty at earlier ages. JF - Annual review of pharmacology and toxicology AU - Fenton, Suzanne E AU - Reed, Casey AU - Newbold, Retha R AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. fentonse@niehs.nih.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 455 EP - 479 VL - 52 KW - Endocrine Disruptors KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - United States KW - Animals KW - Environmental Pollutants -- toxicity KW - Perinatal Care KW - Reproduction -- drug effects KW - Puberty -- drug effects KW - Humans KW - Rodentia -- growth & development KW - Puberty, Precocious -- pathology KW - Body Weight KW - Endocrine Disruptors -- toxicity KW - Puberty, Precocious -- chemically induced KW - Risk Factors KW - Puberty -- physiology KW - Diet KW - Female KW - Environmental Exposure -- analysis KW - Breast -- drug effects KW - Breast -- pathology KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/916145249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+pharmacology+and+toxicology&rft.atitle=%28Q%29SAR+modeling+and+safety+assessment+in+regulatory+review.&rft.au=Kruhlak%2C+N+L%3BBenz%2C+R+D%3BZhou%2C+H%3BColatsky%2C+T+J&rft.aulast=Kruhlak&rft.aufirst=N&rft.date=2012-03-01&rft.volume=91&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2011.300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-03 N1 - Date created - 2012-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Endocrinol. 2010 Jan 27;314(2):164-9 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Apr 1;36(7):1414-8 [11999045] Clin Endocrinol (Oxf). 2002 Jul;57(1):101-6 [12100077] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Toxicology. 2002 Aug 15;177(2-3):197-205 [12135623] Environ Health Perspect. 2002 Aug;110(8):771-6 [12153757] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev-pharmtox-010611-134659 ER - TY - JOUR T1 - Comparison of the effects of antimicrobial agents from three different classes on metabolism of isoflavonoids by colonic microflora using Etest strips. AN - 913317987; 22006071 AB - Daidzein (4',7-dihydroxyisoflavone), a phytoestrogen found in soybeans mainly in the form of its glycoside daidzin, is metabolized by colonic bacteria to compounds with altered estrogenic activities, which may affect human health. Antibacterial agents used for the treatment of infections can alter the composition of bacterial populations in the colon and therefore can affect daidzein metabolism. To rapidly detect the effects of different concentrations of antibiotics on daidzein metabolism by colonic bacteria of monkeys and identify the subpopulation involved in daidzein metabolism, Etest strips containing antibacterial agents from three classes (tetracyclines, fluoroquinolones, and β-lactams) were used to eliminate the colonic bacteria that were susceptible to 0-32 μg/ml of each antibacterial agent and test the surviving bacteria for their ability to metabolize daidzein. The metabolism of daidzein by the colonic microflora was measured before and after the colonic bacterial population was exposed to antibacterial agents. The metabolites were detected by high performance liquid chromatography and mass spectrometry after incubation of the cultures for various times. Exposure of colonic microflora to antibiotics had various effects on daidzein metabolism. Tetracycline completely removed the bacteria metabolizing daidzein, metabolism of daidzein was not changed in cultures of bacteria after ceftriaxone treatment, and ciprofloxacin enriched for the bacteria metabolizing daidzein. In liquid cultures treated with various concentrations of ciprofloxacin, 4 μg/ml of ciprofloxacin favored the growth of bacteria that metabolized daidzein. This is the first time in which the Etest has been used to show that, whereas some antibiotics eliminate phytoestrogen-metabolizing bacteria in colonic microflora, others enrich them by eliminating the non-metabolizing strains in the population. JF - Current microbiology AU - Sutherland, John B AU - Bridges, Brad M AU - Heinze, Thomas M AU - Adams, Michael R AU - Delio, Patrick J AU - Hotchkiss, Charlotte AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 60 EP - 65 VL - 64 IS - 1 KW - Anti-Bacterial Agents KW - 0 KW - Fluoroquinolones KW - Isoflavones KW - beta-Lactams KW - daidzin KW - 4R2X91A5M5 KW - Tetracycline KW - F8VB5M810T KW - Index Medicus KW - Feces -- microbiology KW - Animals KW - Macaca fascicularis KW - Microbial Sensitivity Tests -- instrumentation KW - Humans KW - beta-Lactams -- pharmacology KW - Fluoroquinolones -- pharmacology KW - Tetracycline -- pharmacology KW - Bacteria -- metabolism KW - Colon -- metabolism KW - Colon -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Bacteria -- isolation & purification KW - Bacteria -- drug effects KW - Isoflavones -- metabolism KW - Colon -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913317987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+microbiology&rft.atitle=Comparison+of+the+effects+of+antimicrobial+agents+from+three+different+classes+on+metabolism+of+isoflavonoids+by+colonic+microflora+using+Etest+strips.&rft.au=Sutherland%2C+John+B%3BBridges%2C+Brad+M%3BHeinze%2C+Thomas+M%3BAdams%2C+Michael+R%3BDelio%2C+Patrick+J%3BHotchkiss%2C+Charlotte%3BRafii%2C+Fatemeh&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2012-01-01&rft.volume=64&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Current+microbiology&rft.issn=1432-0991&rft_id=info:doi/10.1007%2Fs00284-011-0020-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-12-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00284-011-0020-4 ER - TY - JOUR T1 - Toxicological significance of azo dye metabolism by human intestinal microbiota. AN - 913032652; 22201895 AB - Approximately 0.7 million tons of azo dyes are synthesized each year. Azo dyes are composed of one or more R₁-N=N-R₂ linkages. Studies have shown that both mammalian and microbial azoreductases cleave the azo bonds of the dyes to form compounds that are potentially genotoxic. The human gastrointestinal tract harbors a diverse microbiota comprised of at least several thousand species. Both water-soluble and water-insoluble azo dyes can be reduced by intestinal bacteria. Some of the metabolites produced by intestinal microbiota have been shown to be carcinogenic to humans although the parent azo dyes may not be classified as being carcinogenic. Azoreductase activity is commonly found in intestinal bacteria. Three types of azoreductases have been characterized in bacteria. They are flavin dependent NADH preferred azoreductase, flavin dependent NADPH preferred azoreductase, and flavin free NADPH preferred azoreductase. This review highlights how azo dyes are metabolized by intestinal bacteria, mechanisms of azo reduction, and the potential contribution in the carcinogenesis/mutagenesis of the reduction of the azo dyes by intestinal microbiota. JF - Frontiers in bioscience (Elite edition) AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2012/01/01/ PY - 2012 DA - 2012 Jan 01 SP - 568 EP - 586 VL - 4 KW - Azo Compounds KW - 0 KW - Carcinogens KW - Coloring Agents KW - Index Medicus KW - Carcinogens -- metabolism KW - Humans KW - Bacteria -- metabolism KW - Azo Compounds -- metabolism KW - Coloring Agents -- toxicity KW - Azo Compounds -- toxicity KW - Coloring Agents -- metabolism KW - Intestines -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913032652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%28Elite+edition%29&rft.atitle=Toxicological+significance+of+azo+dye+metabolism+by+human+intestinal+microbiota.&rft.au=Feng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Feng&rft.aufirst=Jinhui&rft.date=2012-01-01&rft.volume=4&rft.issue=&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%28Elite+edition%29&rft.issn=1945-0508&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-14 N1 - Date created - 2011-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residual viraemia does not influence 1 year virological rebound in HIV-infected patients with HIV RNA persistently below 50 copies/mL AN - 912732734 AB - It is currently debated whether patients with residual viraemia are at higher risk of virological failure than those attaining <1 HIV RNA copy/mL. We therefore investigated the effect of residual viraemia on virological rebound. We used a prospective, non-interventional, single-centre, study. This analysis was based on HIV-infected patients with two consecutive HIV RNA viral loads (VLs) of <50 copies/mL as tested by Versant bDNA, followed by two HIV RNA VLs of <50 copies/mL as tested using the Versant kinetic PCR molecular system (kPCR; limit of quantification = 1 copy/mL). Virological rebound was defined as two consecutive HIV RNA values of >50 copies/mL after baseline, and the time to virological rebound was calculated using the Kaplan-Meier method. There were 739 eligible patients; 446 (60.4%) had HIV RNA <1 copy/mL (group A) and 293 (39.6%) had residual viraemia (1-49 HIV RNA copies/mL; group B). After a follow-up (median 48.9 weeks), virological rebound occurred in four patients in group A (0.9%) and six patients in group B (2%); the time to virological rebound was similar in the two groups (log-rank test P = 0.231). CD4+ cell recovery (slope) was significantly less in the patients with residual viraemia; +14.3 (-7.7, 43.9) cells/mm... per year versus +21.2 (-2.5, 53.2) cells/mm... per year; P = 0.036. Residual viraemia assessed by kPCR was not associated with virological rebound during 1 year of follow-up. However, the patients attaining <1 HIV RNA copy/mL showed a small but statistically significant improvement in CD4+ cell recovery. (ProQuest: ... denotes formulae/symbols omitted.) JF - The Journal of Antimicrobial Chemotherapy AU - Gianotti, Nicola AU - Galli, Laura AU - Racca, Sara AU - Salpietro, Stefania AU - Cossarini, Francesca AU - Spagnuolo, Vincenzo AU - Barda, Beatrice AU - Canducci, Filippo AU - Clementi, Massimo AU - Lazzarin, Adriano AU - Castagna, Antonella Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 213 CY - Oxford PB - Oxford Publishing Limited(England) VL - 67 IS - 1 SN - 03057453 KW - Pharmacy And Pharmacology KW - Human immunodeficiency virus--HIV KW - Ribonucleic acid--RNA KW - Cells KW - Bacteria KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912732734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Residual+viraemia+does+not+influence+1+year+virological+rebound+in+HIV-infected+patients+with+HIV+RNA+persistently+below+50+copies%2FmL&rft.au=Gianotti%2C+Nicola%3BGalli%2C+Laura%3BRacca%2C+Sara%3BSalpietro%2C+Stefania%3BCossarini%2C+Francesca%3BSpagnuolo%2C+Vincenzo%3BBarda%2C+Beatrice%3BCanducci%2C+Filippo%3BClementi%2C+Massimo%3BLazzarin%2C+Adriano%3BCastagna%2C+Antonella&rft.aulast=Gianotti&rft.aufirst=Nicola&rft.date=2012-01-01&rft.volume=67&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Oxford Publishing Limited(England) Jan 2012 N1 - Last updated - 2011-12-27 ER - TY - JOUR T1 - Evaluation of furfuryl alcohol sensitization potential following dermal and pulmonary exposure: enhancement of airway responsiveness. AN - 912638656; 22003193 AB - Furfuryl alcohol is considered by the U.S. Environmental Protection Agency to be a high volume production chemical, with over 1 million pounds produced annually. Due to its high production volume and its numerous industrial and consumer uses, there is considerable potential for work-related exposure, as well as exposure to the general population, through pulmonary, oral, and dermal routes of exposure. Human exposure data report a high incidence of asthma in foundry mold workers exposed to furan resins, suggesting potential immunologic effects. Although furfuryl alcohol was nominated and evaluated for its carcinogenic potential by the National Toxicology Program, studies evaluating its immunotoxicity are lacking. The studies presented here evaluated the immunotoxic potential of furfuryl alcohol following exposure by the dermal and pulmonary routes using a murine model. When tested in a combined irritancy local lymph node assay, furfuryl alcohol was identified to be an irritant and mild sensitizer (EC3 = 25.6%). Pulmonary exposure to 2% furfuryl alcohol resulted in enhanced airway hyperreactivity, eosinophilic infiltration into the lungs, and enhanced cytokine production (IL-4, IL-5, and interferon-γ) by ex vivo stimulated lung-associated draining lymphoid cells. Airway hyperreactivity and eosinophilic lung infiltration were augmented by prior dermal exposure to furfuryl alcohol. These results suggest that furfuryl alcohol may play a role in the development of allergic airway disease and encourage the need for additional investigation. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Franko, Jennifer AU - Jackson, Laurel G AU - Hubbs, Ann AU - Kashon, Michael AU - Meade, B J AU - Anderson, Stacey E AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 105 EP - 115 VL - 125 IS - 1 KW - Air Pollutants KW - 0 KW - Furans KW - Interleukin-5 KW - Interleukin-4 KW - 207137-56-2 KW - Immunoglobulin E KW - 37341-29-0 KW - Interferon-gamma KW - 82115-62-6 KW - furfuryl alcohol KW - D582054MUH KW - Index Medicus KW - Animals KW - Immunoglobulin E -- blood KW - Interleukin-4 -- immunology KW - Mice KW - Interferon-gamma -- immunology KW - Lung -- pathology KW - Mice, Inbred BALB C KW - Lymph Nodes -- cytology KW - Lung -- immunology KW - Bronchoalveolar Lavage Fluid -- immunology KW - Interleukin-5 -- immunology KW - Cells, Cultured KW - Inhalation Exposure KW - Lung -- drug effects KW - Local Lymph Node Assay KW - Lymph Nodes -- drug effects KW - Bronchoalveolar Lavage Fluid -- cytology KW - Administration, Topical KW - Female KW - Lymph Nodes -- immunology KW - Dermatitis, Allergic Contact -- immunology KW - Dermatitis, Irritant -- immunology KW - Respiratory Hypersensitivity -- etiology KW - Dermatitis, Allergic Contact -- etiology KW - Furans -- toxicity KW - Respiratory Hypersensitivity -- immunology KW - Air Pollutants -- toxicity KW - Dermatitis, Irritant -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912638656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Evaluation+of+furfuryl+alcohol+sensitization+potential+following+dermal+and+pulmonary+exposure%3A+enhancement+of+airway+responsiveness.&rft.au=Franko%2C+Jennifer%3BJackson%2C+Laurel+G%3BHubbs%2C+Ann%3BKashon%2C+Michael%3BMeade%2C+B+J%3BAnderson%2C+Stacey+E&rft.aulast=Franko&rft.aufirst=Jennifer&rft.date=2012-01-01&rft.volume=125&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr271 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-06-06 N1 - Date created - 2011-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr271 ER - TY - JOUR T1 - Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. AN - 912637867; 22170360 AB - The evidence for meat intake and renal cell carcinoma (RCC) risk is inconsistent. Mutagens related to meat cooking and processing, and variation by RCC subtype may be important to consider. In a large US cohort, we prospectively investigated intake of meat and meat-related compounds in relation to risk of RCC, as well as clear cell and papillary RCC histologic subtypes. Study participants (492,186) completed a detailed dietary assessment linked to a database of heme iron, heterocyclic amines (HCA), polycyclic aromatic hydrocarbons (PAHs), nitrate, and nitrite concentrations in cooked and processed meats. Over 9 (mean) y of follow-up, we identified 1814 cases of RCC (498 clear cell and 115 papillary adenocarcinomas). HRs and 95% CIs were estimated within quintiles by using multivariable Cox proportional hazards regression. Red meat intake [62.7 g (quintile 5) compared with 9.8 g (quintile 1) per 1000 kcal (median)] was associated with a tendency toward an increased risk of RCC [HR: 1.19; 95% CI: 1.01, 1.40; P-trend = 0.06] and a 2-fold increased risk of papillary RCC [P-trend = 0.002]. Intakes of benzo(a)pyrene (BaP), a marker of PAHs, and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), an HCA, were associated with a significant 20-30% elevated risk of RCC and a 2-fold increased risk of papillary RCC. No associations were observed for the clear cell subtype. Red meat intake may increase the risk of RCC through mechanisms related to the cooking compounds BaP and PhIP. Our findings for RCC appeared to be driven by strong associations with the rarer papillary histologic variant. This study is registered at clinicaltrials.gov as NCT00340015. JF - The American journal of clinical nutrition AU - Daniel, Carrie R AU - Cross, Amanda J AU - Graubard, Barry I AU - Park, Yikyung AU - Ward, Mary H AU - Rothman, Nathaniel AU - Hollenbeck, Albert R AU - Chow, Wong-Ho AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD, USA. carrie.daniel@nih.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 155 EP - 162 VL - 95 IS - 1 KW - Imidazoles KW - 0 KW - Mutagens KW - Polycyclic Compounds KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Risk Factors KW - Humans KW - Incidence KW - Middle Aged KW - Benzo(a)pyrene -- adverse effects KW - Male KW - Imidazoles -- adverse effects KW - Female KW - Carcinoma, Renal Cell -- etiology KW - Meat -- adverse effects KW - Mutagens -- adverse effects KW - Cooking KW - Diet KW - Polycyclic Compounds -- adverse effects KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912637867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Large+prospective+investigation+of+meat+intake%2C+related+mutagens%2C+and+risk+of+renal+cell+carcinoma.&rft.au=Daniel%2C+Carrie+R%3BCross%2C+Amanda+J%3BGraubard%2C+Barry+I%3BPark%2C+Yikyung%3BWard%2C+Mary+H%3BRothman%2C+Nathaniel%3BHollenbeck%2C+Albert+R%3BChow%2C+Wong-Ho%3BSinha%2C+Rashmi&rft.aulast=Daniel&rft.aufirst=Carrie&rft.date=2012-01-01&rft.volume=95&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/10.3945%2Fajcn.111.019364 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-16 N1 - Date created - 2011-12-22 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00340015; ClinicalTrials.gov N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8 [14973110] Br J Cancer. 2011 Sep 27;105(7):1096-104 [21897389] Int J Cancer. 1996 Jan 3;65(1):67-73 [8543399] Princess Takamatsu Symp. 1995;23:85-92 [8844799] Cancer Epidemiol Biomarkers Prev. 1997 Apr;6(4):215-23 [9107425] Lancet. 1999 Feb 27;353(9154):703-7 [10073512] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Causes Control. 2007 Mar;18(2):125-33 [17242980] Urology. 2007 Mar;69(3):452-6 [17382143] Cancer Causes Control. 2007 Dec;18(10):1141-51 [17717631] Public Health Nutr. 2008 Feb;11(2):183-95 [17610761] Hum Pathol. 2009 Jan;40(1):10-29 [19027455] J Natl Cancer Inst. 2008 Dec 3;100(23):1695-706 [19033572] J Am Diet Assoc. 2009 Apr;109(4):656-67 [19328261] Cancer Detect Prev. 2009;32(5-6):340-51 [19303221] Am J Epidemiol. 1986 Jul;124(1):17-27 [3521261] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Int J Epidemiol. 2000 Dec;29(6):1060-4 [11101548] J Soc Biol. 2000;194(1):29-38 [11107547] Carcinogenesis. 2001 Jan;22(1):199-202 [11159760] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Epidemiology. 2001 May;12(3):327-38 [11338313] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Carcinogenesis. 2002 May;23(5):809-15 [12016154] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Redox Rep. 2002;7(4):189-97 [12396663] J Nutr. 2002 Nov;132(11 Suppl):3526S-3529S [12421882] IARC Sci Publ. 2002;156:181-6 [12484160] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Mutat Res. 2003 Dec 10;533(1-2):153-71 [14643418] Environ Mol Mutagen. 2004;43(1):53-74 [14743346] Nat Rev Urol. 2010 May;7(5):245-57 [20448658] Nat Rev Urol. 2010 May;7(5):277-85 [20448661] J Appl Toxicol. 2010 Jul;30(5):402-10 [20186696] Am J Pathol. 2011 Feb;178(2):853-60 [21281817] Comment In: J Urol. 2012 Jun;187(6):2022-3 [22579170] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3945/ajcn.111.019364 ER - TY - JOUR T1 - MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver. AN - 912107813; 21976715 AB - Pyrrolizidine alkaloids (PAs) are the most common plant constituents that poison livestock, wildlife and humans. Riddelliine is a prototype genotoxic PA and has been nominated to be classified as a reasonably anticipated human carcinogen by the US National Toxicology Program (NTP) in the 12th Report on Carcinogens. Riddelliine's nomination is due to the high incidence of liver tumours that were observed in both mice and rats in the NTP tumourigenicity bioassay study. In this current study, we explored whether riddelliine treatment could alter microRNA (miRNA) expression in rat liver and whether the possible deregulation of miRNA was related to mutagenicity and carcinogenicity of riddelliine. Groups of six rats were administered riddelliine at a mutagenic dose of 1 mg/kg body weight or with control vehicle 5 days a week for 12 weeks. A group of six rats treated with aristolochic acid, a renal carcinogen, was used as a tissue-specific negative control. The animals were sacrificed 1 day after the last treatment and the livers were isolated for miRNA expression analysis using miRNA microarrays. miRNA expression was significantly altered by riddelliine treatment. Principal component analysis and hierarchical clustering analysis showed that the miRNA expression profiles were clearly classified into two groups, riddelliine treatment versus other samples. Forty-seven miRNAs were significantly dysregulated by riddelliine treatment, among which 38 were up-regulated and 9 were down-regulated. Functional analysis of these differentially expressed miRNAs by riddelliine revealed that these miRNAs were involved in liver carcinogenicity and toxicity, such as liver proliferation, liver necrosis/cell death, hepatocellular carcinoma, liver hepatomegaly, liver inflammation and liver fibrosis. These results suggest that miRNAs actively respond to a mutagenic dose of riddelliine and the pattern of miRNA expression has the potential to be used as a biomarker of genotoxicity and carcinogenicity for riddelliine and possibly other PAs. JF - Mutagenesis AU - Chen, Tao AU - Li, Zhiguang AU - Yan, Jian AU - Yang, Xi AU - Salminen, William AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 59 EP - 66 VL - 27 IS - 1 KW - Carcinogens KW - 0 KW - MicroRNAs KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Liver -- pathology KW - Rats, Transgenic KW - Liver -- drug effects KW - Dose-Response Relationship, Drug KW - RNA -- isolation & purification KW - Microarray Analysis KW - Liver Neoplasms -- chemically induced KW - Gene Expression Regulation KW - Cluster Analysis KW - Carcinogens -- administration & dosage KW - MicroRNAs -- genetics KW - Carcinogens -- toxicity KW - Pyrrolizidine Alkaloids -- administration & dosage KW - Pyrrolizidine Alkaloids -- toxicity KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912107813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=MicroRNA+expression+profiles+distinguish+the+carcinogenic+effects+of+riddelliine+in+rat+liver.&rft.au=Chen%2C+Tao%3BLi%2C+Zhiguang%3BYan%2C+Jian%3BYang%2C+Xi%3BSalminen%2C+William&rft.aulast=Chen&rft.aufirst=Tao&rft.date=2012-01-01&rft.volume=27&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fger060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-17 N1 - Date created - 2011-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/mutage/ger060 ER - TY - JOUR T1 - Functional comparison of microarray data across multiple platforms using the method of percentage of overlapping functions. AN - 908010042; 22130878 AB - Functional comparison across microarray platforms is used to assess the comparability or similarity of the biological relevance associated with the gene expression data generated by multiple microarray platforms. Comparisons at the functional level are very important considering that the ultimate purpose of microarray technology is to determine the biological meaning behind the gene expression changes under a specific condition, not just to generate a list of genes. Herein, we present a method named percentage of overlapping functions (POF) and illustrate how it is used to perform the functional comparison of microarray data generated across multiple platforms. This method facilitates the determination of functional differences or similarities in microarray data generated from multiple array platforms across all the functions that are presented on these platforms. This method can also be used to compare the functional differences or similarities between experiments, projects, or laboratories. JF - Methods in molecular biology (Clifton, N.J.) AU - Li, Zhiguang AU - Kwekel, Joshua C AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. zhiguang.li@fda.hhs.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 123 EP - 139 VL - 802 KW - Index Medicus KW - Rats KW - Software KW - Animals KW - Programming Languages KW - Humans KW - Computational Biology -- methods KW - Databases, Genetic KW - Internet KW - Gene Expression Profiling -- methods KW - Oligonucleotide Array Sequence Analysis -- methods KW - Molecular Sequence Annotation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/908010042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Functional+comparison+of+microarray+data+across+multiple+platforms+using+the+method+of+percentage+of+overlapping+functions.&rft.au=Li%2C+Zhiguang%3BKwekel%2C+Joshua+C%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Zhiguang&rft.date=2012-01-01&rft.volume=802&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-61779-400-1_9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-30 N1 - Date created - 2011-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-61779-400-1_9 ER - TY - JOUR T1 - Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin. AN - 902344318; 22047163 AB - Recent data, using a murine model, have indicated that dermal exposure to perfluorooctanoic acid (PFOA) induces immune modulation, suggesting that this may be an important route of PFOA exposure. To investigate the dermal penetration potential of PFOA, serum concentrations were analyzed in mice following topical application. Statistically significant and dose-responsive increases in serum PFOA concentrations were identified. In vitro dermal penetration studies also demonstrated that PFOA permeates both mouse and human skin. Investigation into the mechanisms mediating PFOA penetration demonstrated that dermal absorption was strongly dependent upon the ionization status of PFOA. In addition, PFOA solid, but not 1% PFOA/acetone solution, was identified as corrosive using a cultured epidermis in vitro model. Despite its corrosive potential, expression of inflammatory cytokines in the skin of topically exposed mice was not altered. These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure. JF - Journal of toxicology and environmental health. Part A AU - Franko, Jennifer AU - Meade, B J AU - Frasch, H Frederick AU - Barbero, Ana M AU - Anderson, Stacey E AD - Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2012 PY - 2012 DA - 2012 SP - 50 EP - 62 VL - 75 IS - 1 SN - 1528-7394, 1528-7394 KW - Caprylates KW - 0 KW - Cytokines KW - Fluorocarbons KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Inflammation -- chemically induced KW - Mice KW - Inflammation -- metabolism KW - Cytokines -- metabolism KW - Mice, Inbred BALB C KW - Male KW - Female KW - Administration, Topical KW - Inflammation -- pathology KW - Caprylates -- administration & dosage KW - Skin Absorption -- drug effects KW - Fluorocarbons -- administration & dosage KW - Caprylates -- metabolism KW - Fluorocarbons -- toxicity KW - Caprylates -- toxicity KW - Dermis -- pathology KW - Dermis -- drug effects KW - Dermis -- metabolism KW - Fluorocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902344318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Dermal+penetration+potential+of+perfluorooctanoic+acid+%28PFOA%29+in+human+and+mouse+skin.&rft.au=Franko%2C+Jennifer%3BMeade%2C+B+J%3BFrasch%2C+H+Frederick%3BBarbero%2C+Ana+M%3BAnderson%2C+Stacey+E&rft.aulast=Franko&rft.aufirst=Jennifer&rft.date=2012-01-01&rft.volume=75&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.615108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-21 N1 - Date created - 2011-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15287394.2011.615108 ER - TY - JOUR T1 - Ethics and Scientific Integrity in Public Health, Epidemiological and Clinical Research AN - 1627731548 AB - The ethics and scientific integrity of biomedical and public health research requires that researchers behave in appropriate ways. However, this requires more than following of published research guidelines that seek to prevent scientific misconduct relating to serious deviations from widely accepted scientific norms for proposing, conducting, and reporting research (e.g., fabrication or falsification of research data or failures to report potential conflicts of interest). In this paper we argue for a broader account of scientific integrity, one consistent with that defended by the United States Institute of Medicine, involving a commitment to intellectual honesty and personal responsibility for oneʼs actions as a researcher and to practices consistent with the responsible conduct of research and protection of the research participants. Maintaining high standards of ethical and scientific integrity helps to maintain public trust in the research enterprise. An increasing number of authors have pointed to the importance of mentoring and education in relation to the responsible conduct of science in preventing transgressions of scientific integrity. Just like in clinical research and biomedicine, epidemiologists and other public health researchers have the responsibility to exhibit and foster the very highest standards of scientific integrity. JF - Public Health Reviews AU - Coughlin, Steven S AU - Barker, Amyre AU - Dawson, Angus AD - Research Service, Veterans Affairs Medical Center, Washington, DC, USA; Food and Drug Administration, Rockville, MD, USA ; Medicine, Ethics, Society and History, School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK Y1 - 2012 PY - 2012 DA - 2012 SP - 1 EP - 13 CY - Dordrecht PB - Springer Science & Business Media VL - 34 IS - 1 SN - 0301-0422 KW - Medical Sciences--Oncology KW - Ethics KW - clinical research KW - epidemiology KW - plagiarism KW - public health KW - scientific integrity KW - scientific misconduct KW - Biomedicine KW - Clinical research KW - Clinical standards KW - Fabrication KW - Falsification KW - Health KW - Honesty KW - Integrity KW - Medical research KW - Mentoring KW - Misconduct KW - Public health KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627731548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reviews&rft.atitle=Ethics+and+Scientific+Integrity+in+Public+Health%2C+Epidemiological+and+Clinical+Research&rft.au=Coughlin%2C+Steven+S%3BBarker%2C+Amyre%3BDawson%2C+Angus&rft.aulast=Coughlin&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=&rft.issue=571&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Institute of Medicine N1 - Date revised - 2014-11-10 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US ER - TY - JOUR T1 - The U.S. RDA Test Process AN - 1504415028; 201402493 AB - From July through December 2010, three U.S. national libraries, the Library of Congress, the National Agricultural Library, and the National Library of Medicine, coordinated a test of Resource Description and Access (RDA) that included 23 other test participants representing a broad range of institutions. The goal of the RDA test was to assure the operational, technical, and economic feasibility of the new cataloging code in order to help determine whether the national libraries would decide to implement the new code. The design and methodology of the test, how the data were analyzed, and specific impact of RDA on the serials community were presented. Adapted from the source document. JF - Serials Librarian AU - Boehr, Diane AU - Reynolds, Regina Romano AU - Shrader, Tina AD - National Library of Medicine, National Institute of Health, Department of Health and Human Services Y1 - 2012/01// PY - 2012 DA - January 2012 SP - 125 EP - 139 PB - Taylor & Francis, Philadelphia PA VL - 62 IS - 1-4 SN - 0361-526X, 0361-526X KW - Resource Description and Access (RDA) KW - testing KW - methodology KW - data analysis KW - National libraries KW - Serials KW - Testing KW - Data analysis KW - Resource Description & Access-RDA KW - article KW - 12.13: CATALOGUING RULES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504415028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Serials+Librarian&rft.atitle=The+U.S.+RDA+Test+Process&rft.au=Boehr%2C+Diane%3BReynolds%2C+Regina+Romano%3BShrader%2C+Tina&rft.aulast=Boehr&rft.aufirst=Diane&rft.date=2012-01-01&rft.volume=62&rft.issue=1-4&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Serials+Librarian&rft.issn=0361526X&rft_id=info:doi/10.1080%2F0361526X.2012.652485 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2014-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - SELID4 N1 - SubjectsTermNotLitGenreText - National libraries; Testing; Resource Description & Access-RDA; Data analysis; Serials DO - http://dx.doi.org/10.1080/0361526X.2012.652485 ER - TY - JOUR T1 - The genetic toxicity of methylphenidate: a review of the current literature AN - 1443376618; 18643304 AB - Attention deficit/hyperactivity disorder (ADHD), a common children's behavioral disorder, is characterized by inattention, hyperactivity and impulsivity. The disorder is thought to stem from abnormalities in the catecholamine pathway and the symptoms of the disorder have been successfully treated with methylphenidate (MPH) since the FDA approved the drug in the 1950s. MPH underwent the appropriate safety testing as part of the FDA approval process; however, a publication in 2005 that reported significant increases in cytogenetic damage in the lymphocytes of MPH-treated pediatric patients caused concern for patients and their families, the pharmaceutical industry and regulatory agencies. This communication will review the many studies that were subsequently initiated worldwide to address the genetic safety of MPH in both animal models and human subjects. Animal experiments broadened the study protocols used in the 2005 investigation to include a wider dose-range, a longer treatment period and automated scoring of biological endpoints, where possible, to reduce observer bias. The human subject studies replicated the experimental design used in the 2005 study, but increased the treatment periods and the sizes of the study populations. Neither the laboratory animal nor human subject studies found an increase in any of the measures of genetic damage that were evaluated. Taken together, these new studies are consistent with the original safety evaluation of the FDA and do not support the hypothesis that MPH treatment increases the risk of genetic damage in ADHD patients. Published 2012. This article is a US Government work and is in the public domain in the USA. The symptoms of Attention Deficit/Hyperactivity Disorder (ADHD) are effectively treated with methylphenidate (MPH). In 2005, reported increases in cytogenetic damage in the lymphocytes of MPH-treated pediatric patients caused world-wide concern. Numerous studies were initiated to verify or refute the findings. As reviewed in this communication, neither the laboratory animal nor human subject studies found an increase in MPH-induced genetic damage. The subsequent studies do not support the initial hypothesis that MPH treatment increases the risk of genetic damage in ADHD patients. JF - Journal of Applied Toxicology AU - Morris, Suzanne M AU - Petibone, Dayton M AU - Lin, Wei-Jiun AU - Chen, James J AU - Vitiello, Benedetto AU - Witt, Kristine L AU - Mattison, Donald R AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, USA. PY - 2012 SP - 756 EP - 764 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 10 SN - 0260-437X, 0260-437X KW - Genetics Abstracts; Toxicology Abstracts KW - methylphenidate KW - ADHD KW - chromosome damage KW - mutation KW - Pediatrics KW - Attention deficit hyperactivity disorder KW - Animal models KW - Laboratory animals KW - Population studies KW - Methylphenidate KW - Toxicity KW - Lymphocytes KW - Children KW - Catecholamines KW - impulsive behavior KW - Pharmaceuticals KW - Drugs KW - Attention KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443376618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=The+genetic+toxicity+of+methylphenidate%3A+a+review+of+the+current+literature&rft.au=Morris%2C+Suzanne+M%3BPetibone%2C+Dayton+M%3BLin%2C+Wei-Jiun%3BChen%2C+James+J%3BVitiello%2C+Benedetto%3BWitt%2C+Kristine+L%3BMattison%2C+Donald+R&rft.aulast=Morris&rft.aufirst=Suzanne&rft.date=2012-01-01&rft.volume=32&rft.issue=10&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2721 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Pediatrics; Attention deficit hyperactivity disorder; Laboratory animals; Animal models; Methylphenidate; Population studies; Lymphocytes; Toxicity; Children; Catecholamines; impulsive behavior; Pharmaceuticals; Attention; Drugs DO - http://dx.doi.org/10.1002/jat.2721 ER - TY - JOUR T1 - Chemoinformatics and chemical genomics: potential utility of in silico methods AN - 1443376370; 18643307 AB - Computational life sciences and informatics are inseparably intertwined and they lie at the heart of modern biology, predictive quantitative modeling and high-performance computing. Two of the applied biological disciplines that are poised to benefit from such progress are pharmacology and toxicology. This review will describe in silico chemoinformatics methods such as (quantitative) structure-activity relationship modeling and will overview how chemoinformatic technologies are considered in applied regulatory research. Given the post-genomics era and large-scale repositories of omics data that are available, this review will also address potential applications of in silico techniques in chemical genomics. Chemical genomics utilizes small molecules to explore the complex biological phenomena that may not be not amenable to straightforward genetic approach. The reader will gain the understanding that chemoinformatics stands at the interface of chemistry and biology with enabling systems for mapping, statistical modeling, pattern recognition, imaging and database tools. The great potential of these technologies to help address complex issues in the toxicological sciences is appreciated with the applied goal of the protection of public health. Published 2012. This article is a US Government work and is in the public domain in the USA. Two of the applied biological disciplines that are poised to benefit from progress in computational life sciences and informatics are pharmacology and toxicology. This review will describe in silico chemoinformatics methods such as (quantitative) structure-activity relationship modeling and will overview how chemoinformatic technologies are considered in applied regulatory research. Given the post-genomics era and large-scale repositories of omics data that are available, this review will also address potential applications of in silico techniques in chemical genomics. JF - Journal of Applied Toxicology AU - Valerio, Luis G AU - Choudhuri, Supratim AD - Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, White Oak 51, Room 4128, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA., luis.valerio@fda.hhs.gov PY - 2012 SP - 880 EP - 889 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 11 SN - 0260-437X, 0260-437X KW - Genetics Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - in silico toxicology KW - in silico methods KW - informatics KW - QSAR KW - computational toxicology KW - drug safety KW - safety assessment KW - genotoxicity KW - cardiac safety KW - chemoinformatics KW - chemical genomics KW - chemical epigenomics KW - Mathematical models KW - Data processing KW - Pharmacology KW - Informatics KW - Computer applications KW - imaging KW - Public health KW - Databases KW - Pattern recognition KW - USA KW - Reviews KW - Mapping KW - genomics KW - Structure-activity relationships KW - Toxicology KW - Technology KW - Gene mapping KW - G 07880:Human Genetics KW - H 12000:Epidemiology and Public Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443376370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Chemoinformatics+and+chemical+genomics%3A+potential+utility+of+in+silico+methods&rft.au=Valerio%2C+Luis+G%3BChoudhuri%2C+Supratim&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2012-01-01&rft.volume=32&rft.issue=11&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2804 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Data processing; Mathematical models; Informatics; Pharmacology; Computer applications; imaging; Public health; Pattern recognition; Databases; Reviews; genomics; Structure-activity relationships; Gene mapping; Mapping; Toxicology; Technology; USA DO - http://dx.doi.org/10.1002/jat.2804 ER - TY - JOUR T1 - Genotoxicity evaluation of titanium dioxide nanoparticles using the Ames test and Comet assay AN - 1443373766; 18643308 AB - Titanium dioxide nanoparticles (TiO sub(2)-NPs) are being used increasingly for various industrial and consumer products, including cosmetics and sunscreens because of their photoactive properties. Therefore, the toxicity of TiO sub(2)-NPs needs to be thoroughly understood. In the present study, the genotoxicity of 10nm uncoated sphere TiO sub(2)-NPs with an anatase crystalline structure, which has been well characterized in a previous study, was assessed using the Salmonella reverse mutation assay (Ames test) and the single-cell gel electrophoresis (Comet) assay. For the Ames test, Salmonella strains TA102, TA100, TA1537, TA98 and TA1535 were preincubated with eight different concentrations of the TiO sub(2)-NPs for 4h at 37 degree C, ranging from 0 to 4915.2 mu g per plate. No mutation induction was found. Analyses with transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS) showed that the TiO sub(2)-NPs were not able to enter the bacterial cell. For the Comet assay, TK6 cells were treated with 0-200 mu g ml super(-1) TiO sub(2)-NPs for 24h at 37 degree C to detect DNA damage. Although the TK6 cells did take up TiO sub(2)-NPs, no significant induction of DNA breakage or oxidative DNA damage was observed in the treated cells using the standard alkaline Comet assay and the endonuclease III (EndoIII) and human 8-hydroxyguanine DNA-glycosylase (hOGG1)-modified Comet assay, respectively. These results suggest that TiO sub(2)-NPs are not genotoxic under the conditions of the Ames test and Comet assay. Published 2012. This article is a US Government work and is in the public domain in the USA. The genotoxicity of 10 nm anatase titanium dioxide nanoparticles was assessed using the Ames test and Comet assay. The nanoparticles were neither mutagenic in the Ames test nor genotoxic in the Comet assay. The results also suggest that the Ames test may not be suitable to measure the mutagenicity of the nanoparticles because the bacterial cells cannot take up the nanoparticles. JF - Journal of Applied Toxicology AU - Woodruff, Robert S AU - Li, Yan AU - Yan, Jian AU - Bishop, Michelle AU - Jones, MYvonne AU - Watanabe, Fumiya AU - Biris, Alexandru S AU - Rice, Penelope AU - Zhou, Tong AU - Chen, Tao AD - Division of Microbiology, Arkansas Regional Laboratory, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. PY - 2012 SP - 934 EP - 943 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 32 IS - 11 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - titanium dioxide nanoparticles KW - Ames test KW - Comet assay KW - mutations KW - genotoxicity KW - AMES test KW - Transmission electron microscopy KW - Cosmetics KW - Spectroscopy KW - Titanium dioxide KW - Sunscreens KW - Consumers KW - Endonuclease KW - Mutagenicity KW - Genotoxicity KW - Toxicity KW - Gel electrophoresis KW - DNA damage KW - USA KW - 8-Hydroxyguanine KW - Ionizing radiation KW - Microscopy KW - DNA KW - X-ray spectroscopy KW - Salmonella KW - Mutation KW - nanoparticles KW - X 24340:Cosmetics, Toiletries & Household Products KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1443373766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Genotoxicity+evaluation+of+titanium+dioxide+nanoparticles+using+the+Ames+test+and+Comet+assay&rft.au=Woodruff%2C+Robert+S%3BLi%2C+Yan%3BYan%2C+Jian%3BBishop%2C+Michelle%3BJones%2C+MYvonne%3BWatanabe%2C+Fumiya%3BBiris%2C+Alexandru+S%3BRice%2C+Penelope%3BZhou%2C+Tong%3BChen%2C+Tao&rft.aulast=Woodruff&rft.aufirst=Robert&rft.date=2012-01-01&rft.volume=32&rft.issue=11&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2781 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Transmission electron microscopy; Genotoxicity; Cosmetics; Spectroscopy; Ames test; Gel electrophoresis; DNA damage; Titanium dioxide; 8-Hydroxyguanine; Ionizing radiation; Sunscreens; Consumers; Comet assay; Endonuclease; nanoparticles; Mutation; AMES test; Microscopy; X-ray spectroscopy; DNA; Toxicity; Salmonella; USA DO - http://dx.doi.org/10.1002/jat.2781 ER - TY - JOUR T1 - Compliance With Bloodborne Pathogen Standards at Eight Correctional Facilities AN - 1434034750; 18507524 AB - This study had three objectives: (a) to examine compliance with the Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens (BBPs) Standard at eight correctional facilities, (b) to identify potential barriers to compliance, and (c) to discuss steps to address these barriers. Eight facilities of different sizes and locations were visited to examine employer adherence to 15 selected BBP risk reduction activities. Facility compliance was less than 50% for four activities: updating exposure control plans, implementing use of appropriate safer medical devices, soliciting employee input on selection of safer devices, and training medical staff when such devices are implemented. Inconsistent compliance may be due to difficulties in applying the standards in the correctional health care work setting. Any BBP training and health communication activities targeted to correctional health care workers should be tailored to the correctional facility setting. JF - Journal of Correctional Health Care AU - Lehman, Everett J AU - Huy, Janice M AU - Viet, Susan M AU - Gomaa, Ahmed AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA  , ELehman@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 29 EP - 44 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 18 IS - 1 SN - 1078-3458, 1078-3458 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Prisons KW - Communications KW - Safety regulations KW - Health care KW - Training KW - Compliance KW - Pathogens KW - Risk reduction KW - Medical personnel KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434034750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Correctional+Health+Care&rft.atitle=Compliance+With+Bloodborne+Pathogen+Standards+at+Eight+Correctional+Facilities&rft.au=Lehman%2C+Everett+J%3BHuy%2C+Janice+M%3BViet%2C+Susan+M%3BGomaa%2C+Ahmed&rft.aulast=Lehman&rft.aufirst=Everett&rft.date=2012-01-01&rft.volume=18&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Correctional+Health+Care&rft.issn=10783458&rft_id=info:doi/10.1177%2F1078345811421466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Number of references - 28 N1 - Last updated - 2013-10-21 N1 - SubjectsTermNotLitGenreText - Prisons; Safety regulations; Communications; Health care; Training; Compliance; Risk reduction; Pathogens; Medical personnel DO - http://dx.doi.org/10.1177/1078345811421466 ER - TY - JOUR T1 - The utility of the integrated design of the Medical Expenditure Panel Survey to inform mortality related studies AN - 1373426819; 201330952 AB - The analytic capacity of surveys can be dramatically enhanced through the linkage to existing secondary data sources at higher levels of aggregation as well as through direct matches to additional health and socio-economic measures acquired for the same set of sample units from other sources of survey specific or administrative data. In this paper, the capacity of the Medical Expenditure Panel Survey (MEPS) to enhance longitudinal analyses focused on mortality studies is discussed. The first set of analyses examines the differentials in pie-dispositional factors that distinguish a representative group of decedents from their surviving counterparts. This is followed by a more extensive model-based study to assess the relationship between antecedent health and health care related factors and mortality. The relationship between medical expenditure levels over time and mortality is also examined to illustrate the enhanced set of longitudinal analyses that are possible through this framework. These longitudinal analyses are based on linkages of the MEPS to the National Health Interview Survey and the National Death Index. Adapted from the source document. JF - Journal of Economic and Social Measurement AU - Cohen, Steven B AD - Center for Financing, Access and Cost Trends (CFACT), Agency for Healthcare Research and Quality, 540 Gaither Road John M. Eisenberg Building, Rockville, MD 20850, USA scohen@ahrq.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 337 EP - 354 PB - IOS Press, Amsterdam The Netherlands VL - 37 IS - 4 SN - 0747-9662, 0747-9662 KW - Survey integration, MEPS, NHIS, NDI KW - Death KW - Mortality Rates KW - Surveys KW - Health KW - Medicine KW - Health Care Services KW - article KW - 2460: policy, planning, forecasting; social indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373426819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Economic+and+Social+Measurement&rft.atitle=The+utility+of+the+integrated+design+of+the+Medical+Expenditure+Panel+Survey+to+inform+mortality+related+studies&rft.au=Cohen%2C+Steven+B&rft.aulast=Cohen&rft.aufirst=&rft.date=2012-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.title=World+Trade+Center+Chemicals+of+Potential+Concern+and+Selected+Other+Chemical+Agents%3A+Summary+of+Cancer+Classifications+by+the+National+Toxicology+Program+and+International+Agency+for+Research+on+Cancer&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JEMEEZ N1 - SubjectsTermNotLitGenreText - Mortality Rates; Medicine; Health Care Services; Health; Surveys; Death DO - http://dx.doi.org/10.3233/JEM-120363 ER - TY - JOUR T1 - Transforming Community Health and Primary Care Education Using Clinical and Administrative Data and Geographic Information Systems AN - 1373423130; 201306497 AB - Community-oriented primary care (COPC), a common model used for integrating the principles of primary care and public health, has been taught in family medicine residency programs to create community-responsive providers. As the initial step in a comprehensive COPC curriculum for a family medicine residency program, we used GIS maps, graphs, and tables to introduce new interns to the community served by the residency clinic. A fourteen-question pre/post test showed that interns' knowledge and understanding of the community improvement overall were deficient. Using practice-based administrative data combined with population-based data can efficiently and effectively improve interns' knowledge of the communities they serve. Adapted from the source document. JF - Journal of Map & Geography Libraries AU - Hayashi, Arthur Seiji AU - Bazemore, Andrew AU - McIntyre, Jessica AD - Health Resources and Services Administration, Bureau of Primary Health Care, Washington, DC, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 61 EP - 70 PB - Haworth/Taylor & Francis, Philadelphia PA VL - 7 IS - 1 SN - 1542-0353, 1542-0353 KW - Community medicine, community oriented primary care, geographic information systems (GIS), residency education KW - Education KW - Communities KW - Health care KW - Medicine KW - Geographic information systems KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1373423130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Map+%26+Geography+Libraries&rft.atitle=Transforming+Community+Health+and+Primary+Care+Education+Using+Clinical+and+Administrative+Data+and+Geographic+Information+Systems&rft.au=Hayashi%2C+Arthur+Seiji%3BBazemore%2C+Andrew%3BMcIntyre%2C+Jessica&rft.aulast=Hayashi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2013-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Communities; Geographic information systems; Health care; Medicine; Education ER - TY - JOUR T1 - Accumulating Evidence for a Drug-Drug Interaction Between Methotrexate and Proton Pump Inhibitors AN - 1367482692; 16643426 AB - BACKGROUND: A number of medications are known to interact with methotrexate through various mechanisms. The aim of this article is to apprise practitioners of a new labeling change based on the accumulating evidence for a possible drug-drug interaction between methotrexate (primarily at high doses) and proton pump inhibitors (PPIs). METHODS: The U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database of spontaneous adverse event reports and the published literature were searched for cases reporting an interaction between methotrexate and PPIs. RESULTS: A search of the AERS database and existing literature found several individual case reports of drug-drug interactions and three additional supportive studies that suggest potential underlying mechanisms for the interaction. CONCLUSION: There is evidence to suggest that concomitant use of methotrexate (primarily at high doses) with PPIs such as omeprazole, esomeprazole, and pantoprazole may decrease methotrexate clearance, leading to elevated serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. In several case reports, no methotrexate toxicity was found when a histamine H2 blocker was substituted for a PPI. Based on the reviewed data, the FDA updated the methotrexate label to include the possible drug-drug interaction between high-dose methotrexate and PPIs. Physicians should be alerted to this potential drug-drug interaction in patients receiving concomitant high-dose methotrexate and PPIs. JF - Oncologist AU - Bezabeh, Shewit AU - Mackey, Ann Corken AU - Kluetz, Paul AU - Jappar, Dilara AU - Korvick, Joyce AD - Office of Surveillance and Epidemiology and Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 550 EP - 554 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 United States VL - 17 IS - 4 SN - 1083-7159, 1083-7159 KW - Toxicology Abstracts KW - Serum levels KW - Databases KW - Data processing KW - Case reports KW - Protons KW - Methotrexate KW - Omeprazole KW - Metabolites KW - Toxicity KW - Histamine KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367482692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncologist&rft.atitle=Accumulating+Evidence+for+a+Drug-Drug+Interaction+Between+Methotrexate+and+Proton+Pump+Inhibitors&rft.au=Bezabeh%2C+Shewit%3BMackey%2C+Ann+Corken%3BKluetz%2C+Paul%3BJappar%2C+Dilara%3BKorvick%2C+Joyce&rft.aulast=Bezabeh&rft.aufirst=Shewit&rft.date=2012-01-01&rft.volume=17&rft.issue=4&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Serum levels; Databases; Data processing; Case reports; Protons; Omeprazole; Methotrexate; Metabolites; Toxicity; Histamine ER - TY - JOUR T1 - Evaluation of a Bladder Cancer Cluster in a Population of Criminal Investigators with the Bureau of Alcohol, Tobacco, Firearms and Explosives-Part 1: The Cancer Incidence AN - 1356933672; 18053492 AB - This study investigated a bladder cancer cluster in a cohort of employees, predominately criminal investigators, participating in a medical surveillance program with the United States Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) between 1995 and 2007. Standardized incidence ratios (SIRs) were used to compare cancer incidences in the ATF population and the US reference population. Seven cases of bladder cancer (five cases verified by pathology report at time of analysis) were identified among a total employee population of 3,768 individuals. All cases were white males and criminal investigators. Six of seven cases were in the 30 to 49 age range at the time of diagnosis. The SIRs for white male criminal investigators undergoing examinations were 7.63 (95% confidence interval = 3.70-15.75) for reported cases and 5.45 (2.33-12.76) for verified cases. White male criminal investigators in the ATF population are at statistically significant increased risk for bladder cancer. JF - Journal of Environmental and Public Health AU - Davis, Susan R AU - Tao, Xuguang AU - Bernacki, Edward J AU - Alfriend, Amy S AD - Federal Occupational Health, Department of Health and Human Services, 4550 Montgomery Avenue, Suite 950, Bethesda, MD 20814, USA, sdavis228@comcast.net Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-9805, 1687-9805 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Alcohol KW - USA KW - Age KW - Firearms KW - Pathology KW - Urinary bladder KW - Tobacco KW - Standards KW - Explosives KW - Cancer KW - H 7000:Fire Safety KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356933672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.atitle=Epigenetic+and+Mirna+Dysregulation+in+Liver+Nongenotoxic+and+Genotoxic+Tumorigenesis&rft.au=Kutanzi%2C+K%3BMelnyk%2C+S%3BKoturbash%2C+I%3BPogribny%2C+I&rft.aulast=Kutanzi&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 1 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Alcohol; Age; Pathology; Firearms; Urinary bladder; Tobacco; Standards; Explosives; Cancer; USA DO - http://dx.doi.org/10.1155/2012/101850 ER - TY - JOUR T1 - Levels of Dichlorodiphenyltrichloroethane and its Metabolites in the Blood of Agrochemicals Retailers AN - 1356925514; 17933829 AB - Problem statement: In tropical countries like Nigeria, the storage, sales and handling of pesticide by agrochemical retailers in indoor stores located in open markets and residential areas were fraught with problem of undesirable side effect. Serum levels of 1, 1, 1-trichloro-2, 2-di (4-chlorophenyl) ethane (DDT) and its metabolite were measured among agrochemicals retailers in Taraba, Nigeria. Approach: Blood samples from 50 retailers were taken and analyzed by gas chromatography with an electron capture detector. The retailers were group into five exposure duration based on their years of involvement in trade viz; 1-5 years, 6-10 years, 11-15 years, 16-20 years, greater than or equal to 21 years. Results: Test detected 34 (50) retailers had residues of DDE, DDD, DDT and Aldrin in their blood. 68% of the retailers had DDE at mean concentration of 0.047 mg L-1, ranged from n.d-0.0721 mg L-1. 62% DDD (mean = 0.0101 mg L-1, range = n.d-0.034 mg L-1), 58% DDT (mean = 0.0120 mg L-1, ranged = n.d-0.1120 mg L-1) and 52% Aldrin (mean = 0.0045 mg L-1, ranged = 0.0100-0.0265 mg L-1), The total content DDT(sum of DDE, DDD and DDT ) in the whole blood samples was 0.062 mg L-1 and ranged from 0.0008-0.185 mg L-1. Dieldrin was not detected in any of the samples analyzed. Conclusion: Despite the banned, the observed trend for all the DDTs and metabolites shows that retailers are occupationally exposed due to the sales and handling of agrochemicals in retailers' stores. The need for stiffmonitoring and enforcement by regulatory bodies is of paramount important. JF - American Journal of Environmental Sciences AU - Hotton, Anthony J AU - Barminas, Jeoffrey T AU - Osemeahon, Sunday A AD - National Agency for Food and Drug Administration and Control, P.M.B 1018 Jalingo, Taraba State, Nigeria Y1 - 2012 PY - 2012 DA - 2012 SP - 170 PB - Science Publications, Vails Gate Heights Dr Vails Gate NY 12584 United States VL - 8 IS - 2 SN - 1553-345X, 1553-345X KW - Health & Safety Science Abstracts KW - Nigeria KW - Insecticides KW - Nitrous oxide KW - Residues KW - Ethane KW - DDT KW - Aldrin KW - DDE KW - Metabolites KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1356925514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Environmental+Sciences&rft.atitle=Levels+of+Dichlorodiphenyltrichloroethane+and+its+Metabolites+in+the+Blood+of+Agrochemicals+Retailers&rft.au=Hotton%2C+Anthony+J%3BBarminas%2C+Jeoffrey+T%3BOsemeahon%2C+Sunday+A&rft.aulast=Thompson&rft.aufirst=K&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-05-01 N1 - Number of references - 16 N1 - Last updated - 2013-06-14 N1 - SubjectsTermNotLitGenreText - Insecticides; Residues; Nitrous oxide; Ethane; DDE; Aldrin; DDT; Metabolites; Occupational exposure; Nigeria ER - TY - JOUR T1 - Factors affecting the performance, energy consumption, and carbon footprint for ultra low temperature freezers: case study at the National Institutes of Health AN - 1318696194; 17760702 AB - The National Institutes of Health (NIH) recognises an opportunity to significantly reduce the energy consumption and its carbon footprint from plug load equipment can be realised by managing -86 degree C ultra low temperature (ULT) freezers. Energy meters were installed on ULT freezers operating in actual laboratory conditions to determine how their energy consumption is influenced by various factors. Ambient temperature, freezer condition, age, capacity, and set point temperature were the factors that were examined. Based on the study, ultra low temperature freezers operated efficiently when they are: well maintained, operating in ambient temperatures less than 25 degree C, less than ten years old, are operating at a set point higher than -80 degree C, and have an internal capacity greater than 23 ft super(3). The results of the case study are presented and discussed. Freezer performance was assessed to determine how ambient temperature and the freezer condition influenced the freezer's ability to reach set point temperature. The results of the study indicate a freezer that is not maintained and operating in ambient temperatures above 32 degree C produce cabinet temperatures 12.5 degree C warmer than the desired set point temperature. JF - World Review of Science, Technology and Sustainable Development AU - Gumapas, Leo Angelo M AU - Simons, Glenn AD - US Public Health Service Commissioned Corps, Office of Research Facilities, Division of Environmental Protection, National Institutes of Health, Room 2W64, 9000 Rockville Pike Building 13, Bethesda, MD 20892, USA. Y1 - 2012 PY - 2012 DA - 2012 SP - 129 EP - 141 PB - Inderscience Publishers Ltd., PO Box 735 Olney Bucks MK46 5WB United Kingdom VL - 10 IS - 1-2-3 SN - 1741-2242, 1741-2242 KW - Health & Safety Science Abstracts; Environment Abstracts; Sustainability Science Abstracts KW - ENERGY AND ENVIRONMENT KW - MANAGEMENT AND BUSINESS KW - Environment and Sustainable Development KW - Operational Management and Marketing KW - Policy and Organisational Management KW - Age KW - Low temperature KW - Case studies KW - Reviews KW - Temperature KW - Sustainable development KW - Energy consumption KW - ENA 03:Energy KW - M3 1010:Issues in Sustainable Development KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1318696194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+Review+of+Science%2C+Technology+and+Sustainable+Development&rft.atitle=Factors+affecting+the+performance%2C+energy+consumption%2C+and+carbon+footprint+for+ultra+low+temperature+freezers%3A+case+study+at+the+National+Institutes+of+Health&rft.au=Mellon%2C+D&rft.aulast=Mellon&rft.aufirst=D&rft.date=2012-03-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2012%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Case studies; Low temperature; Reviews; Temperature; Sustainable development; Energy consumption DO - http://dx.doi.org/10.1504/WRSTSD.2013.050786 ER - TY - JOUR T1 - The upper midwest health study: a case-control study of pesticide applicators and risk of glioma AN - 1315614787; 17720860 AB - Background: An excess incidence of brain cancer in farmers has been noted in several studies. The National Institute for Occupational Safety and Health developed the Upper Midwest Health Study (UMHS) as a case-control study of intracranial gliomas and pesticide uses among rural residents. Previous studies of UMHS participants, using "ever-never" exposure to farm pesticides and analyzing men and women separately, found no positive association of farm pesticide exposure and glioma risks. The primary objective was to determine if quantitatively estimated exposure of pesticide applicators was associated with an increased risk of glioma in male and female participants. Methods: The study included 798 histologically confirmed primary intracranial glioma cases (45 % with proxy respondents) and 1,175 population-based controls, all adult (age 18-80) non-metropolitan residents of Iowa, Michigan, Minnesota, and Wisconsin. The analyses used quantitatively estimated exposure from questionnaire responses evaluated by an experienced industrial hygienist with 25 years of work on farm pesticide analyses. Odds ratios (ORs) and 95 % confidence intervals (CIs) using unconditional logistic regression modeling were calculated adjusting for frequency-matching variables (10-year age group and sex), and for age and education (a surrogate for socioeconomic status). Analyses were separately conducted with or without proxy respondents. Results: No significant positive associations with glioma were observed with cumulative years or estimated lifetime cumulative exposure of farm pesticide use. There was, a significant inverse association for phenoxy pesticide used on the farm (OR 0.96 per 10 g-years of cumulative exposure, CI 0.93-0.99). No significant findings were observed when proxy respondents were excluded. Non-farm occupational applicators of any pesticide had decreased glioma risk: OR 0.72, CI 0.52-0.99. Similarly, house and garden pesticide applicators had a decreased risk of glioma: OR 0.79, CI 0.66-0.93, with statistically significant inverse associations for use of 2,4-D, arsenates, organophosphates, and phenoxys. Conclusions: These results are consistent with our previous findings for UMHS of reported farm pesticide exposure and support a lack of positive association between pesticides and glioma. JF - Environmental Health (London) AU - Yiin, James H AU - Ruder, Avima M AU - Stewart, Patricia A AU - Waters, Martha A AU - Carreon, Tania AU - Butler, Mary Ann AU - Calvert, Geoffrey M AU - Davis-King, Karen E AU - Schulte, Paul A AU - Mandel, Jack S AU - Morton, Roscoe F AU - Reding, Douglas J AU - Rosenman, Kenneth D AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 39 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1476-069X, 1476-069X KW - Pollution Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - 2,4-Dichlorophenoxyacetic acid KW - USA, Iowa KW - Pesticides KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315614787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+%28London%29&rft.atitle=The+upper+midwest+health+study%3A+a+case-control+study+of+pesticide+applicators+and+risk+of+glioma&rft.au=Yiin%2C+James+H%3BRuder%2C+Avima+M%3BStewart%2C+Patricia+A%3BWaters%2C+Martha+A%3BCarreon%2C+Tania%3BButler%2C+Mary+Ann%3BCalvert%2C+Geoffrey+M%3BDavis-King%2C+Karen+E%3BSchulte%2C+Paul+A%3BMandel%2C+Jack+S%3BMorton%2C+Roscoe+F%3BReding%2C+Douglas+J%3BRosenman%2C+Kenneth+D&rft.aulast=Yiin&rft.aufirst=James&rft.date=2012-01-01&rft.volume=11&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+%28London%29&rft.issn=1476069X&rft_id=info:doi/10.1186%2F1476-069X-11-39 L2 - http://www.ehjournal.net/content/11/1/39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Pesticides; USA, Iowa DO - http://dx.doi.org/10.1186/1476-069X-11-39 ER - TY - JOUR T1 - Clinical and Epidemiologic Features of Diarrheal Disease due to Aeromonas hydrophila and Plesiomonas shigelloides Infections Compared with Those due to Vibrio cholerae Non-O1 and Vibrio parahaemolyticus in Bangladesh AN - 1315610184; 17590842 AB - Using data from the International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) from 1996 to 2001, we compared the clinical features of diarrhea in patients with stool specimens yielding only A. hydrophila (189 patients; 1.4% of 13,970 patients screened) or P. shigelloides (253 patients) compared to patients with sole V. cholerae non-O1 infection (99 patients) or V. parahaemolyticus infection (126 patients). Patients exhibited similar frequencies of fever (temperature >37.8 degree C), stools characterized as watery, and stools containing visible mucus. Dehydration was observed more often among patients with V. parahaemolyticus or V. cholerae non-O1 infection. Compared to patients infected with V. parahaemolyticus , those with A. hydrophila , P. shigelloides , or V. cholerae non-O1 infection were less likely to report visible blood in the stool and, on microscopic examination, less likely to exhibit stool red blood cell and white blood cell counts exceeding 20 cells per high power field. The proportion of patients reporting subjective cure at the time of discharge was significantly smaller for those infected with V. parahaemolyticus. These findings suggest that A. hydrophila and P. shigelloides produce diarrheal disease that is less severe than that resulting from infection with V. cholerae non-O1 or V. parahaemolyticus. JF - ISRN Microbiology AU - Klontz, Erik H AU - Faruque, Abu SG AU - Das, Sumon K AU - Malek, Mohammed A AU - Islam, Zhahirul AU - Luby, Stephen P AU - Klontz, Karl C AD - Carleton College, One North College Street, Northfield, MN 55057, USA, karl.klontz@fda.hhs.gov Y1 - 2012/01// PY - 2012 DA - January 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Temperature effects KW - Diarrhea KW - Data processing KW - Pathogenic bacteria KW - Leukocytes KW - Erythrocytes KW - Aeromonas hydrophila KW - Mucus KW - Infection KW - Public health KW - Fever KW - Vibrio cholerae KW - Plesiomonas shigelloides KW - Vibrio parahaemolyticus KW - Microbiology KW - Blood cells KW - Feces KW - Bangladesh KW - Dehydration KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1315610184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISRN+Microbiology&rft.atitle=Clinical+and+Epidemiologic+Features+of+Diarrheal+Disease+due+to+Aeromonas+hydrophila+and+Plesiomonas+shigelloides+Infections+Compared+with+Those+due+to+Vibrio+cholerae+Non-O1+and+Vibrio+parahaemolyticus+in+Bangladesh&rft.au=Klontz%2C+Erik+H%3BFaruque%2C+Abu+SG%3BDas%2C+Sumon+K%3BMalek%2C+Mohammed+A%3BIslam%2C+Zhahirul%3BLuby%2C+Stephen+P%3BKlontz%2C+Karl+C&rft.aulast=Klontz&rft.aufirst=Erik&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ISRN+Microbiology&rft.issn=2090-7486&rft_id=info:doi/10.5402%2F2012%2F654819 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-03-01 N1 - Number of references - 4 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Pathogenic bacteria; Erythrocytes; Microbiology; Mucus; Blood cells; Public health; Dehydration; Temperature effects; Fever; Data processing; Diarrhea; Leukocytes; Feces; Infection; Vibrio cholerae; Plesiomonas shigelloides; Vibrio parahaemolyticus; Aeromonas hydrophila; Bangladesh DO - http://dx.doi.org/10.5402/2012/654819 ER - TY - JOUR T1 - Evidence for validity of five secondary data sources for enumerating retail food outlets in seven American Indian Communities in North Carolina AN - 1285094858; 17611515 AB - Background: Most studies on the local food environment have used secondary sources to describe the food environment, such as government food registries or commercial listings (e.g., Reference USA). Most of the studies exploring evidence for validity of secondary retail food data have used on-site verification and have not conducted analysis by data source (e.g., sensitivity of Reference USA) or by food outlet type (e.g., sensitivity of Reference USA for convenience stores). Few studies have explored the food environment in American Indian communities. To advance the science on measuring the food environment, we conducted direct, on-site observations of a wide range of food outlets in multiple American Indian communities, without a list guiding the field observations, and then compared our findings to several types of secondary data. Methods: Food outlets located within seven State Designated Tribal Statistical Areas in North Carolina (NC) were gathered from online Yellow Pages, Reference USA, Dun & Bradstreet, local health departments, and the NC Department of Agriculture and Consumer Services. All TIGER/Line 2009 roads (>1,500 miles) were driven in six of the more rural tribal areas and, for the largest tribe, all roads in two of its cities were driven. Sensitivity, positive predictive value, concordance, and kappa statistics were calculated to compare secondary data sources to primary data. Results: 699 food outlets were identified during primary data collection. Match rate for primary data and secondary data differed by type of food outlet observed, with the highest match rates found for grocery stores (97%), general merchandise stores (96%), and restaurants (91%). Reference USA exhibited almost perfect sensitivity (0.89). Local health department data had substantial sensitivity (0.66) and was almost perfect when focusing only on restaurants (0.91). Positive predictive value was substantial for Reference USA (0.67) and moderate for local health department data (0.49). Evidence for validity was comparatively lower for Dun & Bradstreet, online Yellow Pages, and the NC Department of Agriculture. Conclusions: Secondary data sources both over- and under-represented the food environment; they were particularly problematic for identifying convenience stores and specialty markets. More attention is needed to improve the validity of existing data sources, especially for rural local food environments. JF - International Journal of Behavioral Nutrition and Physical Activity AU - Fleischhacker, Sheila E AU - Rodriguez, Daniel A AU - Evenson, Kelly R AU - Henley, Amanda AU - Gizlice, Ziya AU - Soto, Dolly AU - Ramachandran, Gowri AD - Senior Public Health & Science Policy Advisor, NIH Division of Nutrition Research Coordination, National Institutes of Health, US Department of Health and Human Services, Two Democracy Plaza, Room 635, 6707 Democracy Boulevard, MSC 5461, Bethesda, MD, 20892-5461, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 137 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1479-5868, 1479-5868 KW - Physical Education Index KW - Analysis KW - Diet KW - Exercise KW - Health KW - Indians KW - Observation KW - Restaurants KW - Statistics KW - Validity KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285094858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.atitle=Evidence+for+validity+of+five+secondary+data+sources+for+enumerating+retail+food+outlets+in+seven+American+Indian+Communities+in+North+Carolina&rft.au=Fleischhacker%2C+Sheila+E%3BRodriguez%2C+Daniel+A%3BEvenson%2C+Kelly+R%3BHenley%2C+Amanda%3BGizlice%2C+Ziya%3BSoto%2C+Dolly%3BRamachandran%2C+Gowri&rft.aulast=Fleischhacker&rft.aufirst=Sheila&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Nutrition+and+Physical+Activity&rft.issn=14795868&rft_id=info:doi/10.1186%2F1479-5868-9-137 L2 - http://www.ijbnpa.org/content/9/1/137 LA - English DB - Physical Education Index N1 - Date revised - 2013-02-01 N1 - Number of references - 47 N1 - Last updated - 2013-03-11 N1 - SubjectsTermNotLitGenreText - Indians; Statistics; Restaurants; Analysis; Validity; Observation; Health; Exercise; Diet DO - http://dx.doi.org/10.1186/1479-5868-9-137 ER - TY - JOUR T1 - Type I interferon and pattern recognition receptor signaling following particulate matter inhalation AN - 1272752317; 17574364 AB - Background: Welding, a process that generates an aerosol containing gases and metal-rich particulates, induces adverse physiological effects including inflammation, immunosuppression and cardiovascular dysfunction. This study utilized microarray technology and subsequent pathway analysis as an exploratory search for markers/mechanisms of in vivo systemic effects following inhalation. Mice were exposed by inhalation to gas metal arc - stainless steel (GMA-SS) welding fume at 40 mg/m super(3) for 3 hr/d for 10 d and sacrificed 4 hr, 14 d and 28 d post-exposure. Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling. Results: The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28 d. Remarkably, these effects showed consistency across all tissues indicating a systemic type I interferon response that was complemented by changes in serum proteins (decreased MMP-9, CRP and increased VCAM1, oncostatin M, IP-10). In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. Also, a canonical pathway indicated a coordinated response of multiple PRR and associated signaling molecules (Tlr7, Tlr2, Clec7a, Nlrp3, Myd88) to inhalation of GMA-SS. Conclusion: This methodological approach has the potential to identify consistent, prominent and/or novel pathways and provides insight into mechanisms that contribute to pulmonary and systemic effects following toxicant exposure. JF - Particle and Fibre Toxicology AU - Erdely, Aaron AU - Antonini, James M AU - Salmen-Muniz, Rebecca AU - Liston, Angie AU - Hulderman, Tracy AU - Simeonova, Petia P AU - Kashon, Michael L AU - Li, Shengqiao AU - Gu, Ja K AU - Stone, Samuel AU - Chen, Bean T AU - Frazer, David G AU - Zeidler-Erdely, Patti C AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 25 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Microarray KW - Welding KW - Interferon regulatory factor 7 KW - Cardiovascular disease KW - Chromium KW - Biomarker KW - Pattern recognition receptor KW - Whole blood cell gene expression KW - Aorta KW - Inhalation KW - beta -Interferon KW - Aerosols KW - TLR2 protein KW - DNA microarrays KW - Inflammation KW - Gene expression KW - oncostatin M KW - Pattern recognition KW - Lung KW - Transcription factors KW - alpha -Interferon KW - Gelatinase B KW - TLR7 protein KW - Toll-like receptors KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272752317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Type+I+interferon+and+pattern+recognition+receptor+signaling+following+particulate+matter+inhalation&rft.au=Erdely%2C+Aaron%3BAntonini%2C+James+M%3BSalmen-Muniz%2C+Rebecca%3BListon%2C+Angie%3BHulderman%2C+Tracy%3BSimeonova%2C+Petia+P%3BKashon%2C+Michael+L%3BLi%2C+Shengqiao%3BGu%2C+Ja+K%3BStone%2C+Samuel%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BZeidler-Erdely%2C+Patti+C&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-9-25 L2 - http://www.particleandfibretoxicology.com/content/9/1/25 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Number of references - 51 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Inhalation; Aerosols; Interferon regulatory factor 7; Aorta; TLR2 protein; DNA microarrays; Inflammation; Gene expression; Pattern recognition; oncostatin M; Lung; Transcription factors; alpha -Interferon; Welding; TLR7 protein; Gelatinase B; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1186/1743-8977-9-25 ER - TY - JOUR T1 - Effects of multiple conformers per compound upon 3-D similarity search and bioassay data analysis AN - 1272737969; 17574570 AB - Background: To improve the utility of PubChem, a public repository containing biological activities of small molecules, the PubChem3D project adds computationally-derived three-dimensional (3-D) descriptions to the small-molecule records contained in the PubChem Compound database and provides various search and analysis tools that exploit 3-D molecular similarity. Therefore, the efficient use of PubChem3D resources requires an understanding of the statistical and biological meaning of computed 3-D molecular similarity scores between molecules. Results: The present study investigated effects of employing multiple conformers per compound upon the 3-D similarity scores between ten thousand randomly selected biologically-tested compounds (10-K set) and between non-inactive compounds in a given biological assay (156-K set). When the "best-conformer-pair" approach, in which a 3-D similarity score between two compounds is represented by the greatest similarity score among all possible conformer pairs arising from a compound pair, was employed with ten diverse conformers per compound, the average 3-D similarity scores for the 10-K set increased by 0.11, 0.09, 0.15, 0.16, 0.07, and 0.18 for ST super( ST-opt ), CT super( ST-opt ), ComboT super( ST-opt ), ST super( CT-opt ), CT super( CT-opt ), and ComboT super( CT-opt ), respectively, relative to the corresponding averages computed using a single conformer per compound. Interestingly, the best-conformer-pair approach also increased the average 3-D similarity scores for the non-inactive-non-inactive (NN) pairs for a given assay, by comparable amounts to those for the random compound pairs, although some assays showed a pronounced increase in the per-assay NN-pair 3-D similarity scores, compared to the average increase for the random compound pairs. Conclusion: These results suggest that the use of ten diverse conformers per compound in PubChem bioassay data analysis using 3-D molecular similarity is not expected to increase the separation of non-inactive from random and inactive spaces "on average", although some assays show a noticeable separation between the non-inactive and random spaces when multiple conformers are used for each compound. The present study is a critical next step to understand effects of conformational diversity of the molecules upon the 3-D molecular similarity and its application to biological activity data analysis in PubChem. The results of this study may be helpful to build search and analysis tools that exploit 3-D molecular similarity between compounds archived in PubChem and other molecular libraries in a more efficient way. JF - Journal of Cheminformatics AU - Kim, Sunghwan AU - Bolton, Evan E AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, 20894, MD, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 28 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 4 IS - 1 SN - 1758-2946, 1758-2946 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Databases KW - Informatics KW - Statistics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1272737969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=Effects+of+multiple+conformers+per+compound+upon+3-D+similarity+search+and+bioassay+data+analysis&rft.au=Kim%2C+Sunghwan%3BBolton%2C+Evan+E%3BBryant%2C+Stephen+H&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2012-01-01&rft.volume=4&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=17582946&rft_id=info:doi/10.1186%2F1758-2946-4-28 L2 - http://www.jcheminf.com/content/4/1/28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-01-01 N1 - Number of references - 55 N1 - Last updated - 2013-02-08 N1 - SubjectsTermNotLitGenreText - Databases; Statistics; Data processing; Informatics DO - http://dx.doi.org/10.1186/1758-2946-4-28 ER - TY - JOUR T1 - Effects of ultrasound and ultrasound contrast agent on vascular tissue AN - 1221146695; 17379405 AB - Background: Ultrasound (US) imaging can be enhanced using gas-filled microbubble contrast agents. Strong echo signals are induced at the tissue-gas interface following microbubble collapse. Applications include assessment of ventricular function and virtual histology. Aim: While ultrasound and US contrast agents are widely used, their impact on the physiological response of vascular tissue to vasoactive agents has not been investigated in detail. Methods and results: In the present study, rat dorsal aortas were treated with US via a clinical imaging transducer in the presence or absence of the US contrast agent, Optison. Aortas treated with both US and Optison were unable to contract in response to phenylephrine or to relax in the presence of acetylcholine. Histology of the arteries was unremarkable. When the treated aortas were stained for endothelial markers, a distinct loss of endothelium was observed. Importantly, terminal deoxynucleotidyl transferase mediated dUTP nick-end-labeling (TUNEL) staining of treated aortas demonstrated incipient apoptosis in the endothelium. Conclusions: Taken together, these ex vivo results suggest that the combination of US and Optison may alter arterial integrity and promote vascular injury; however, the in vivo interaction of Optison and ultrasound remains an open question. JF - Cardiovascular Ultrasound AU - Wood, Steven C AU - Antony, Sible AU - Brown, Ronald P AU - Chen, Jin AU - Gordon, Edward A AU - Hitchins, Victoria M AU - Zhang, Qin AU - Liu, Yunbo AU - Maruvada, Subha AU - Harris, Gerald R AD - Food and Drug Administration, Center for Devices and Radiological Health (CDRH), 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 29 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 10 IS - 1 SN - 1476-7120, 1476-7120 KW - Biotechnology and Bioengineering Abstracts KW - Acetylcholine KW - Aorta KW - Apoptosis KW - Arteries KW - Contrast media KW - DNA nucleotidylexotransferase KW - Endothelium KW - Injuries KW - Ultrasound KW - Vasoactive agents KW - imaging KW - phenylephrine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221146695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+Ultrasound&rft.atitle=Effects+of+ultrasound+and+ultrasound+contrast+agent+on+vascular+tissue&rft.au=Wood%2C+Steven+C%3BAntony%2C+Sible%3BBrown%2C+Ronald+P%3BChen%2C+Jin%3BGordon%2C+Edward+A%3BHitchins%2C+Victoria+M%3BZhang%2C+Qin%3BLiu%2C+Yunbo%3BMaruvada%2C+Subha%3BHarris%2C+Gerald+R&rft.aulast=Wood&rft.aufirst=Steven&rft.date=2012-01-01&rft.volume=10&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+Ultrasound&rft.issn=14767120&rft_id=info:doi/10.1186%2F1476-7120-10-29 L2 - http://www.cardiovascularultrasound.com/content/10/1/29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Number of references - 49 N1 - Last updated - 2012-12-04 N1 - SubjectsTermNotLitGenreText - phenylephrine; Apoptosis; Injuries; Arteries; Aorta; Endothelium; Contrast media; Acetylcholine; imaging; Ultrasound; DNA nucleotidylexotransferase; Vasoactive agents DO - http://dx.doi.org/10.1186/1476-7120-10-29 ER - TY - JOUR T1 - Interventions to Promote an Integrated Approach to Public Health Problems: An Application to Childhood Obesity AN - 1221139126; 17366101 AB - Experts stress the need to bring the childhood obesity epidemic under control by means of an integrated approach. The implementation of such an approach requires the development of integrated enabling policies on public health by local governments. A prerequisite for developing such integrated public health policies is intersectoral collaboration. Since the development of integrated policies is still in its early stages, this study aimed to answer the following research question: "What interventions can promote intersectoral collaboration and the development of integrated health policies for the prevention of childhood obesity? " Data were collected through a literature search and observations of and interviews with stakeholders. Based on a theoretical framework, we categorized potential interventions that could optimize an integrated approach regarding children's physical activity and diet. The intervention categories included education, persuasion, incentivization, coercion, training, restriction, environmental restructuring, modeling, and enablement. JF - Journal of Environmental and Public Health AU - Hendriks, Anna-Marie AU - Gubbels, Jessica S AU - De Vries, Nanne K AU - Seidell, Jaap C AU - Kremers, Stef PJ AU - Jansen, Maria WJ AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, P.O. Box 2022, 6160 HA Geleen, The Netherlands, anna-marie.hendriks@maastrichtuniversity.nl Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-9805, 1687-9805 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Diets KW - Obesity KW - Stakeholders KW - Education KW - Physical activity KW - Intervention KW - Persuasion KW - Children KW - Public health KW - H 12000:Epidemiology and Public Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221139126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+and+Public+Health&rft.atitle=Interventions+to+Promote+an+Integrated+Approach+to+Public+Health+Problems%3A+An+Application+to+Childhood+Obesity&rft.au=Hendriks%2C+Anna-Marie%3BGubbels%2C+Jessica+S%3BDe+Vries%2C+Nanne+K%3BSeidell%2C+Jaap+C%3BKremers%2C+Stef+PJ%3BJansen%2C+Maria+WJ&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+and+Public+Health&rft.issn=16879805&rft_id=info:doi/10.1155%2F2012%2F913236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Number of references - 1 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Diets; Stakeholders; Obesity; Education; Physical activity; Intervention; Persuasion; Children; Public health DO - http://dx.doi.org/10.1155/2012/913236 ER - TY - JOUR T1 - The effects of recall length and reporting aids on household reporting of health care events in the medical expenditure panel survey AN - 1171852086; 4364935 AB - We examined the effects of length of recall period and written records on the accuracy of household reports of health care use of Medicare beneficiaries in the Medical Expenditure Panel Survey (M EPS), a widely used nationally-representative federal survey. Our sample contained 1,375 Medicare beneficiaries with 5 complete rounds of MEPS interviews during 2001-2003 who were matched to their Medicare claims records. Household respondents systematically underreported any emergency department use per round (mean of 0.07 vs. 0.09 in the claims, p <0.001) and number of ambulatory visits per 90 days (2.3 vs. 2.7, p < 0.001). In logistic regressions, recall periods less than 2 months and, to a lesser extent, 3 to 4 months were associated with lower odds of underreporting visits and higher overall accuracy. Calendars and bills, insurance statements, and other records of health care events kept by some MEPS respondents also were associated with lower odds of underreporting. Adapted from the source document. Reprinted by permission of IOS Press JF - Journal of economic and social measurement AU - Zuvekas, Samuel H AD - Agency for Healthcare Research and Quality Y1 - 2012 PY - 2012 DA - 2012 SP - 321 EP - 343 VL - 36 IS - 4 SN - 0747-9662, 0747-9662 KW - Economics KW - Health economics KW - Health expenditure KW - Health care KW - Surveys KW - Medical treatment KW - Medicine KW - U.S.A. KW - Panel surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171852086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+economic+and+social+measurement&rft.atitle=The+effects+of+recall+length+and+reporting+aids+on+household+reporting+of+health+care+events+in+the+medical+expenditure+panel+survey&rft.au=Zuvekas%2C+Samuel+H&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2012-01-01&rft.volume=36&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+economic+and+social+measurement&rft.issn=07479662&rft_id=info:doi/10.3233%2FJEM-2011-0348 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7894; 12429; 5775 13521; 9149 12429; 5778 4025; 5780 4618; 7890 5792 10484; 433 293 14 DO - http://dx.doi.org/10.3233/JEM-2011-0348 ER - TY - JOUR T1 - Implementation of school health promotion: consequences for professional assistance AN - 1125282704; 201225676 AB - Purpose -- This case study aimed to examine the factors influencing the implementation of health promotion (HP) policies and programs in secondary schools and the consequences for professional assistance. Design/methodology/approach -- Group interviews were held in two schools that represented the best and worst case of implementation of a health promotion program ("Schoolbeat") in the Southern Limburg region. Both schools were represented by the school manager, the health care coordinator and their school health promotion (SHP) advisor. The main purpose of the group interview was to describe the organization of HP in the school. Findings -- Efforts to improve organizational aspects like change management, collaborative support and project management contributed to the implementation of HP. Practical implications -- Based on these results the authors advise SHP advisors to focus more on the organizational aspects of HP in schools. Originality/value -- This study contributes to the discussion about the tasks of HP professionals assisting secondary schools. Results show that effective assistance in shaping school health promotion requires competencies that go beyond organizing practical HP activities. HP professionals assisting schools need skills covering many aspects of the field, ranging from professional assistance for the process of implementing HP to organizational skills to advise and guide schools on the organizational changes needed for the implementation of HP. Adapted from the source document. JF - Health Education AU - Boot, N.M.W.M. AU - de Vries, N.K. AD - Department of Health Promotion, Regional Public Health Service (GGD) Southern Limburg, Geleen, The Netherlands nicole.boot@ggdzl.nl Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 436 EP - 447 PB - Emerald Group Publishing Ltd., Bradford UK VL - 112 IS - 5 SN - 0965-4283, 0965-4283 KW - School health promotion Secondary schools Schoolbeat approach Collaboration Health education Project management Change management KW - Advisers KW - Secondary schools KW - Institutional aspects KW - Project management KW - Methodology KW - Health promotion KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1125282704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education&rft.atitle=Implementation+of+school+health+promotion%3A+consequences+for+professional+assistance&rft.au=Boot%2C+N.M.W.M.%3Bde+Vries%2C+N.K.&rft.aulast=Boot&rft.aufirst=N.M.W.M.&rft.date=2012-01-01&rft.volume=112&rft.issue=5&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Health+Education&rft.issn=09654283&rft_id=info:doi/10.1108%2F09654281211253443 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-11-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Health promotion; Secondary schools; Institutional aspects; Advisers; Methodology; Project management DO - http://dx.doi.org/10.1108/09654281211253443 ER - TY - JOUR T1 - A validation study comparing two self-reported upper extremity symptom surveys with clinical examinations for upper extremity musculoskeletal disorders AN - 1113218274; 17253182 AB - Objective: Evaluate the validity of two self-report symptoms surveys with two disorder classification protocols.Participants: 100 graduate students at a private school in the Southwest United States.Methods: Study participants completed two self-report upper extremity musculoskeletal symptoms surveys: a nine item 10 cm Visual Analogue Scale (VAS) and a nine item Likert categorical scale anchored from "None" to "Very severe". Clinical examinations were administered using two musculoskeletal disorder classification protocols.Results: For the nine body regions, concordance between the two self-report symptoms scales ranged from 0.490.75. Overall there was greater than 80% agreement for the two disorder classification protocols. Using either symptom survey with either disorder classification protocol provided high sensitivities and specificities (Youden's J 0.70). Three of possible six symptom survey/classification protocol pairings provided high sensitivities and specificities across all disorder groups.Conclusion: In this graduate student sample, none of the self-report symptom survey-classification protocol pairings was demonstratively more useful than any other pairing for studies of musculoskeletal disorders among computer users. JF - Work AU - Amick, Benjamin C, III AU - Caroom, Cyrus AU - Katz, Jeffrey N AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 293 EP - 302 PB - IOS Press, Nieuwe Hemweg 6B Amsterdam 1013 BG Netherlands VL - 43 IS - 3 SN - 1051-9815, 1051-9815 KW - Health & Safety Science Abstracts KW - Computing-related KW - graduate students KW - Youden's J KW - sensitivity KW - specificity KW - Sensitivity KW - Musculoskeletal system KW - Schools KW - Classification KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1113218274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Work&rft.atitle=A+validation+study+comparing+two+self-reported+upper+extremity+symptom+surveys+with+clinical+examinations+for+upper+extremity+musculoskeletal+disorders&rft.au=Amick%2C+Benjamin+C%2C+III%3BCaroom%2C+Cyrus%3BKatz%2C+Jeffrey+N&rft.aulast=Amick&rft.aufirst=Benjamin&rft.date=2012-01-01&rft.volume=43&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Work&rft.issn=10519815&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Sensitivity; Schools; Musculoskeletal system; Classification ER - TY - JOUR T1 - Trench Safety-Using a Qualitative Approach to Understand Barriers and Develop Strategies to Improve Trenching Practices AN - 1093469426; 17032738 AB - Despite efforts to ensure workplace safety and health, injuries and fatalities related to trenching and excavation remain alarmingly high in the construction industry. Because properly installed trenching protective systems can potentially reduce the significant number of trenching fatalities, there is clearly a need to identify the barriers to the use of these systems and to develop strategies to ensure these systems are utilized consistently. The current study reports on the results of focus groups with construction workers and safety management personnel to better understand these barriers and to identify solutions. The results suggest several factors, from poor planning to pressures from experienced workers and supervisors, which present barriers to safe trenching practices. Based on the results, it is recommended that safety trainings incorporate unique messages for new workers, experienced workers and management in an effort to motivate each group to work safely as well as provide them with solutions to overcome the identified barriers. JF - International Journal of Construction Education and Research AU - Flynn, Michael A AU - Sampson, Julie M AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 63 EP - 79 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 8 IS - 1 SN - 1557-8771, 1557-8771 KW - Health & Safety Science Abstracts KW - Construction industry KW - Education KW - Injuries KW - Mortality KW - Training KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093469426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Construction+Education+and+Research&rft.atitle=Trench+Safety-Using+a+Qualitative+Approach+to+Understand+Barriers+and+Develop+Strategies+to+Improve+Trenching+Practices&rft.au=Flynn%2C+Michael+A%3BSampson%2C+Julie+M&rft.aulast=Flynn&rft.aufirst=Michael&rft.date=2012-01-01&rft.volume=8&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Construction+Education+and+Research&rft.issn=15578771&rft_id=info:doi/10.1080%2F15578771.2011.633973 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Mortality; Education; Injuries; Training; Construction industry DO - http://dx.doi.org/10.1080/15578771.2011.633973 ER - TY - JOUR T1 - Effect of calibration and environmental condition on the performance of direct-reading organic vapor monitors. AN - 1081437097; 23016630 AB - The performance of three MIRAN SapphIRe Portable Infrared Ambient Air Analyzers and three Century Portable Toxic Vapor Analyzers equipped with photoionization (PID) and flame ionization (FID) detectors was compared with charcoal tube sampling. Relationships were investigated using two different calibration methods at four cyclohexane concentrations, three temperatures, and four relative humidities. For the first method, the TVA monitors were calibrated with a single concentration of methane for the FID, and isobutylene for the PID. The SapphIRe monitors were zeroed and the monitor's manufacturer-supplied library was used. For the second method, a five-point cyclohexane calibration curve was created for each monitor. Comparison of the monitor results of each calibration method (pooled data) indicated a significant difference between methods (t-test, p < 0.001), The SapphIRe group had results closer to the charcoal tubes with the second calibration method, while the PID and FID monitor groups performed better using the first calibration method. The PID monitor group's performance was affected only at the 90% relative humidity (RH) condition. Using the first method, the monitor readings were compared with the charcoal tube average using mixed linear model analyses of variance (ANOVAs) and regression. The ANOVA results showed there was a statistically significant difference among readings from all monitor types (p <0.0001). The regression results demonstrated that the SapphIRe (r² = 0.97) and FID (r² = 0.92) monitor groups correlated well with the charcoal tubes. The PID monitor group had a similar correlation when 90% RH was excluded (r² = 0.94) but had a weaker correlation when it was included (r² = 0.58). The operator should take care when using these monitors at high concentrations and the PID monitors at high humidities, consider the variability between units of the same monitor, and conduct performance verification of the monitor being used. JF - Journal of occupational and environmental hygiene AU - Coffey, Christopher AU - LeBouf, Ryan AU - Lee, Larry AU - Slaven, James AU - Martin, Stephen AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. ccc3@cdc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 670 EP - 680 VL - 9 IS - 11 KW - Air Pollutants, Occupational KW - 0 KW - Cyclohexanes KW - Cyclohexane KW - 48K5MKG32S KW - Index Medicus KW - False Negative Reactions KW - Analysis of Variance KW - Flame Ionization KW - Linear Models KW - Temperature KW - Photochemical Processes KW - Humidity KW - Calibration KW - False Positive Reactions KW - Air Pollutants, Occupational -- analysis KW - Cyclohexanes -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081437097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Effect+of+calibration+and+environmental+condition+on+the+performance+of+direct-reading+organic+vapor+monitors.&rft.au=Coffey%2C+Christopher%3BLeBouf%2C+Ryan%3BLee%2C+Larry%3BSlaven%2C+James%3BMartin%2C+Stephen&rft.aulast=Coffey&rft.aufirst=Christopher&rft.date=2012-01-01&rft.volume=9&rft.issue=11&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2013-02-22 N1 - Date created - 2012-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational Exposure to Acrylamide in Closed System Production Plants: Air Levels and Biomonitoring AN - 1069195190; 17139332 AB - The aim of this study was to evaluate biomarkers of acrylamide exposure, including hemoglobin adducts and urinary metabolites in acrylamide production workers. Biomarkers are integrated measures of the internal dose, and it is total acrylamide dose from all routes and sources that may present health risks. Workers from three companies were studied. Workers potentially exposed to acrylamide monomer wore personal breathing-zone air samplers. Air samples and surface-wipe samples were collected and analyzed for acrylamide. General-area air samples were collected in chemical processing units and control rooms. Hemoglobin adducts were isolated from ethylenediamine teraacetic acid (EDTA)-whole blood, and adducts of acrylamide and glycidamide, at the N-terminal valines of hemoglobin, were cleaved from the protein chain by use of a modified Edman reaction. Full work-shift, personal breathing zone, and general-area air samples were collected and analyzed for particulate and acrylamide monomer vapor. The highest general-area concentration of acrylamide vapor was 350 mu g/cm3 in monomer production. Personal breathing zone and general-area concentrations of acrylamide vapor were found to be highest in monomer production operations, and lower levels were in the polymer production operations. Adduct levels varied widely among workers, with the highest in workers in the monomer and polymer production areas. The acrylamide adduct range was 15-1884 pmol/g; glycidamide adducts ranged from 17.8 to 1376 p/mol/g. The highest acrylamide and glycidamide adduct levels were found among monomer production process operators. The primary urinary metabolite N-acetyl-S-(2-carbamoylethyl) cysteine (NACEC) ranged from the limit of detection to 15.4 mu g/ml. Correlation of workplace exposure and sentinel health effects is needed to determine and control safe levels of exposure for regulatory standards. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Moorman, William J AU - Reutman, Susan S AU - Shaw, Peter B AU - Blade, Leo Michael AU - Marlow, David AU - Vesper, Hubert AU - Clark, John C AU - Schrader, Steven M AD - CDC-NIOSH, DART, EPHB, Cincinnati, Ohio, USA Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 100 EP - 111 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 75 IS - 2 SN - 1528-7394, 1528-7394 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Chemical process industry KW - Respiration KW - Metabolites KW - Particulates KW - Hemoglobin KW - Workers KW - Vapors KW - Air sampling KW - biomonitoring KW - Occupational exposure KW - Bioindicators KW - Adducts KW - Samplers KW - biomarkers KW - Monomers KW - Blood KW - Acrylamide KW - Urine KW - Cysteine KW - valine KW - Polymers KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1069195190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Occupational+Exposure+to+Acrylamide+in+Closed+System+Production+Plants%3A+Air+Levels+and+Biomonitoring&rft.au=Moorman%2C+William+J%3BReutman%2C+Susan+S%3BShaw%2C+Peter+B%3BBlade%2C+Leo+Michael%3BMarlow%2C+David%3BVesper%2C+Hubert%3BClark%2C+John+C%3BSchrader%2C+Steven+M&rft.aulast=Moorman&rft.aufirst=William&rft.date=2012-01-01&rft.volume=75&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2011.615109 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Adducts; Respiration; Metabolites; biomarkers; Samplers; Monomers; Hemoglobin; Workers; Blood; Vapors; Acrylamide; Cysteine; biomonitoring; valine; Occupational exposure; Bioindicators; Chemical process industry; Urine; Air sampling; Particulates; Polymers DO - http://dx.doi.org/10.1080/15287394.2011.615109 ER - TY - JOUR T1 - Qualitative determination of carbon black in food products AN - 1038614638; 17032568 AB - Carbon black (C.I. 77266) is an insoluble pigment produced by the partial combustion of hydrocarbons. The pigment is known by several synonyms, including vegetable carbon, lamp black and carbon ash, that correspond to the raw materials and methods used for its production. Vegetable carbon (E153) is permitted for use in colouring food in the European Union. The US Food and Drug Administration (USFDA) has not approved the use of any type of carbon black for colouring food, although the agency batch certifies the pigment as D&C Black No. 2 for use in colouring certain cosmetics. Since carbon black (as vegetable carbon) may be present in food products offered for import into the United States, the USFDA's district laboratories need a qualitative analytical method for determining its presence. We have developed an extraction method for this purpose. A sample is broken down and dissolved with nitric acid. The resulting solution is filtered and treated with hydrochloric acid to dissolve any black iron oxide also present as a colour additive. A black residue remaining on the filter paper indicates the presence of carbon black in the food. We confirmed the presence of carbon black in residues from several standards and food products using Raman spectroscopy. The limit of detection for this method is 0.0001%. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Miranda-Bermudez, E AU - Belai, N AU - Harp, BPetigara AU - Yakes, B J AU - Barrows, J N AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, USA Y1 - 2012/01// PY - 2012 DA - Jan 2012 SP - 38 EP - 42 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 29 IS - 1 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Black carbon KW - Combustion KW - Food additives KW - Iron KW - Nitric acid KW - Pigments KW - Raw materials KW - Residues KW - Risk assessment KW - USA KW - European Union KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038614638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Qualitative+determination+of+carbon+black+in+food+products&rft.au=Miranda-Bermudez%2C+E%3BBelai%2C+N%3BHarp%2C+BPetigara%3BYakes%2C+B+J%3BBarrows%2C+J+N&rft.aulast=Miranda-Bermudez&rft.aufirst=E&rft.date=2012-01-01&rft.volume=29&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.616535 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Black carbon; Residues; Pigments; Nitric acid; Iron; Raw materials; Combustion; USA; European Union DO - http://dx.doi.org/10.1080/19440049.2011.616535 ER - TY - GEN T1 - Managing Chronic Pain in Adults with or in Recovery from Substance Use Disorders. Treatment Improvement Protocol (TIP) Series 54 AN - 1037906806; ED533525 AB - Chronic noncancer pain (CNCP) is common in the general population as well as in people who have a substance use disorder (SUD) (Exhibit 1-1). Chronic pain is not harmless; it has physiological, social, and psychological dimensions that can seriously harm health, functioning, and well-being. As a multidimensional condition with both objective and subjective aspects, CNCP is difficult to assess and treat. Although CNCP can be managed, it usually cannot be completely eliminated. When patients with CNCP have comorbid SUD or are recovering from SUD, a complex condition becomes even more difficult to manage. This Treatment Improvement Protocol (TIP) is for primary care providers who treat or are likely to treat adult patients with or in recovery from SUDs who present with CNCP. Given the prevalence of CNCP in the population, this audience includes virtually all primary care providers. Addiction specialists, psychiatrists, nurses, and other clinicians may find information here that will help them ensure that their patients with CNCP receive adequate pain treatment. By providing a shared basic understanding of and a common language for these two chronic conditions, this TIP facilitates cooperation and communication between healthcare professionals treating pain and those treating addiction. This TIP equips clinicians with practical guidance and tools for treating CNCP in adults with histories of SUDs. It provides readers with information about SUD assessments and referrals for further evaluation. For patients with histories of SUDs, the most controversial and possibly hazardous pain treatment in widespread use is opioid treatment. For this reason, this topic receives significant attention in Chapters 3 and 4. Appended are: (1) Bibliography; (2) Assessment Tools and Resources; (3) CFR Sample Consent Form and List of Personal Identifiers; (4) Resources for Finding Complementary and Alternative Therapy Practitioners; (5) Field Reviewers; and (6) Acknowledgments. A section on patient education is also included as well as an index. (Contains 50 exhibits.) Y1 - 2012 PY - 2012 DA - 2012 SP - 128 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Support Staff KW - Substance Abuse KW - Clinical Diagnosis KW - Chronic Illness KW - Pain KW - Adults KW - Patient Education KW - Comorbidity KW - Outcomes of Treatment KW - Evaluation Methods KW - Compliance (Psychology) KW - Health Behavior KW - Coping KW - Neurology KW - At Risk Persons KW - Drug Therapy KW - Physical Therapy KW - Screening Tests KW - Family Involvement KW - Addictive Behavior KW - Counseling Techniques KW - Behavior Modification KW - Guides KW - Cognitive Restructuring KW - Drug Rehabilitation KW - Internet KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037906806?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Pulmonary Toxicity, Distribution, and Clearance of Intratracheally Instilled Silicon Nanowires in Rats AN - 1031310006; 16809023 AB - Silicon nanowires (Si NWs) are being manufactured for use as sensors and transistors for circuit applications. The goal was to assess pulmonary toxicity and fate of Si NW using an in vivo experimental model. Male Sprague-Dawley rats were intratracheally instilled with 10, 25, 50, 100, or 250 mu g of Si NW (~20-30 nm diameter; ~2-15 mu m length). Lung damage and the pulmonary distribution and clearance of Si NW were assessed at 1, 3, 7, 28, and 91 days after-treatment. Si NW treatment resulted in dose-dependent increases in lung injury and inflammation that resolved over time. At day 91 after treatment with the highest doses, lung collagen was increased. Approximately 70% of deposited Si NW was cleared by 28 days with most of the Si NW localized exclusively in macrophages. In conclusion, Si NW induced transient lung toxicity which may be associated with an early rapid particle clearance; however, persistence of Si NW over time related to dose or wire length may lead to increased collagen deposition in the lung. JF - Journal of Nanomaterials AU - Roberts, Jenny R AU - Mercer, Robert R AU - Chapman, Rebecca S AU - Cohen, Guy M AU - Bangsaruntip, Sarunya AU - Schwegler-Berry, Diane AU - Scabilloni, James F AU - Castranova, Vincent AU - Antonini, James M AU - Leonard, Stephen S AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, jur6@cdc.gov Y1 - 2012/01// PY - 2012 DA - Jan 2012 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2012 SN - 1687-4110, 1687-4110 KW - Toxicology Abstracts KW - Macrophages KW - Silicon KW - Injuries KW - Lung KW - Circuits KW - Toxicity KW - nanotechnology KW - Collagen KW - Models KW - Inflammation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1031310006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanomaterials&rft.atitle=Pulmonary+Toxicity%2C+Distribution%2C+and+Clearance+of+Intratracheally+Instilled+Silicon+Nanowires+in+Rats&rft.au=Roberts%2C+Jenny+R%3BMercer%2C+Robert+R%3BChapman%2C+Rebecca+S%3BCohen%2C+Guy+M%3BBangsaruntip%2C+Sarunya%3BSchwegler-Berry%2C+Diane%3BScabilloni%2C+James+F%3BCastranova%2C+Vincent%3BAntonini%2C+James+M%3BLeonard%2C+Stephen+S&rft.aulast=Roberts&rft.aufirst=Jenny&rft.date=2012-01-01&rft.volume=2012&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanomaterials&rft.issn=16874110&rft_id=info:doi/10.1155%2F2012%2F398302 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 37 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Silicon; Injuries; Lung; Circuits; Toxicity; Inflammation; Models; Collagen; nanotechnology DO - http://dx.doi.org/10.1155/2012/398302 ER - TY - JOUR T1 - Despite 2007 Law Requiring FDA Hotline To Be Included In Print Drug Ads, Reporting Of Adverse Events By Consumers Still Low AN - 1030885928; 2011-304176 AB - In 2007 the federal government began requiring drug makers to include in their print direct-to-consumer advertisements information for consumers on how to contact the Food and Drug Administration directly, either by phone or through the agency's website, to report any adverse events that they experienced after taking a prescription drug. Adverse events can range from minor skin problems like itching to serious injuries or illness that result in hospitalization, permanent disability, or even death. Even so, current rates of adverse event reporting are low. We studied adverse event reports about 123 drugs that came from patients before and after the enactment of the print advertising requirement and estimated that requirement's impact with model simulations. We found that if monthly spending on print direct-to-consumer advertising increased from zero to $7.7 million per drug, the presence of the Food and Drug Administration contact information tripled the increase in patient-reported adverse events, compared to what would have happened in the absence of the law. However, the absolute monthly increase was fewer than 0.24 reports per drug, suggesting that the public health impact of the increase was small and that the adverse event reporting rate would still be low. The study results suggest that additional measures, such as more publicity about the Adverse Event Reporting System or more consumer education, should be considered to promote patient reporting of adverse events. Adapted from the source document. JF - Health Affairs AU - Du, Dongyi "Tony" AU - Goldsmith, John AU - Aikin, Kathryn J AU - Encinosa, William E AU - Nardinelli, Clark AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland dongyi.du@fda.hhs.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 1022 EP - 1029 PB - Project HOPE, Bethesda MD VL - 31 IS - 5 SN - 0278-2715, 0278-2715 KW - Business and service sector - Markets, marketing, and merchandising KW - Manufacturing and heavy industry - Container industry KW - Manufacturing and heavy industry - Pharmaceutical industry KW - Economic conditions and policy - Economic policy, planning, and development KW - Law and ethics - Law and jurisprudence KW - Economic conditions and policy - Consumers and consumption KW - Business and service sector - Advertising and public relations KW - Health conditions and policy - Health and health policy KW - United States Food and drug administration KW - Labels KW - Marketing KW - Pharmaceutical industry KW - Advertising KW - Regulation KW - Consumer protection KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030885928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Despite+2007+Law+Requiring+FDA+Hotline+To+Be+Included+In+Print+Drug+Ads%2C+Reporting+Of+Adverse+Events+By+Consumers+Still+Low&rft.au=Du%2C+Dongyi+%22Tony%22%3BGoldsmith%2C+John%3BAikin%2C+Kathryn+J%3BEncinosa%2C+William+E%3BNardinelli%2C+Clark&rft.aulast=Du&rft.aufirst=Dongyi&rft.date=2012-01-01&rft.volume=31&rft.issue=5&rft.spage=1022&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Marketing; Labels; Pharmaceutical industry; United States Food and drug administration; Regulation; Consumer protection; Advertising; Public health ER - TY - JOUR T1 - Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos AN - 1028034885; 16884942 AB - Background: Carbon nanotubes (CNT) and carbon nanofibers (CNF) are allotropes of carbon featuring fibrous morphology. The dimensions and high aspect ratio of CNT and CNF have prompted the comparison with naturally occurring asbestos fibers which are known to be extremely pathogenic. While the toxicity and hazardous outcomes elicited by airborne exposure to single-walled CNT or asbestos have been widely reported, very limited data are currently available describing adverse effects of respirable CNF. Results: Here, we assessed pulmonary inflammation, fibrosis, oxidative stress markers and systemic immune responses to respirable CNF in comparison to single-walled CNT (SWCNT) and asbestos. Pulmonary inflammatory and fibrogenic responses to CNF, SWCNT and asbestos varied depending upon the agglomeration state of the particles/fibers. Foci of granulomatous lesions and collagen deposition were associated with dense particle-like SWCNT agglomerates, while no granuloma formation was found following exposure to fiber-like CNF or asbestos. The average thickness of the alveolar connective tissue - a marker of interstitial fibrosis - was increased 28 days post SWCNT, CNF or asbestos exposure. Exposure to SWCNT, CNF or asbestos resulted in oxidative stress evidenced by accumulations of 4-HNE and carbonylated proteins in the lung tissues. Additionally, local inflammatory and fibrogenic responses were accompanied by modified systemic immunity, as documented by decreased proliferation of splenic T cells ex vivo on day 28 post exposure. The accuracies of assessments of effective surface area for asbestos, SWCNT and CNF (based on geometrical analysis of their agglomeration) versus estimates of mass dose and number of particles were compared as predictors of toxicological outcomes. Conclusions: We provide evidence that effective surface area along with mass dose rather than specific surface area or particle number are significantly correlated with toxicological responses to carbonaceous fibrous nanoparticles. Therefore, they could be useful dose metrics for risk assessment and management. JF - Particle and Fibre Toxicology AU - Murray, Ashley R AU - Kisin, Elena R AU - Tkach, Alexey V AU - Yanamala, Naveena AU - Mercer, Robert AU - Young, Shih-Houng AU - Fadeel, Bengt AU - Kagan, Valerian E AU - Shvedova, Anna A AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 10 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 9 IS - 1 SN - 1743-8977, 1743-8977 KW - Toxicology Abstracts KW - Asbestos KW - Fibrosis KW - Connective tissues KW - Surface area KW - Spleen KW - Toxicity KW - Granuloma KW - Alveoli KW - Inflammation KW - Collagen KW - Fibers KW - Carbon KW - Oxidative stress KW - Lung KW - Lymphocytes T KW - nanotubes KW - Immune response KW - nanoparticles KW - Agglomeration KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028034885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Factoring-in+agglomeration+of+carbon+nanotubes+and+nanofibers+for+better+prediction+of+their+toxicity+versus+asbestos&rft.au=Murray%2C+Ashley+R%3BKisin%2C+Elena+R%3BTkach%2C+Alexey+V%3BYanamala%2C+Naveena%3BMercer%2C+Robert%3BYoung%2C+Shih-Houng%3BFadeel%2C+Bengt%3BKagan%2C+Valerian+E%3BShvedova%2C+Anna+A&rft.aulast=Murray&rft.aufirst=Ashley&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=17438977&rft_id=info:doi/10.1186%2F1743-8977-9-10 L2 - http://www.particleandfibretoxicology.com/content/9/1/10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 57 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Asbestos; Connective tissues; Fibrosis; Surface area; Spleen; Toxicity; Granuloma; Alveoli; Collagen; Inflammation; Fibers; Carbon; Lung; Oxidative stress; Lymphocytes T; nanotubes; Immune response; nanoparticles; Agglomeration DO - http://dx.doi.org/10.1186/1743-8977-9-10 ER - TY - JOUR T1 - Velocity model determination for accurate location of mining-induced seismic events AN - 1026860977; 2012-067688 AB - Determining the location of mining-induced seismic events is strongly dependent on having an accurate velocity model. However, such a model is seldom available. This paper describes the determination of a velocity model for seismic event location, using the seismic events themselves as sources whose location is to be determined along with the parameters of the velocity model (a simultaneous inversion of event locations and velocity structure). Seismic monitoring of a mine in Colorado is used as an example, with an array of geophones installed both on the surface and in underground roadways. Velocity models of increasing complexity are considered, starting with a homogeneous velocity, moving to a (slightly dipping) layered-earth model, and eventually including static time shifts to account for the effects of a weathered, near-surface, low-velocity layer on arrival times at geophones mounted on the surface, This series of increasingly complex models obviously shows increasingly better fits to the data, but also shows more plausible event locations, and with more realistic elevation spans. Examination of spatial patters in the residuals indicates that there are likely mining-induced changes in velocity that are not accounted for in the model. JF - ASEG Extended Abstracts AU - King, Andrew AU - Anonymous Y1 - 2012 PY - 2012 DA - 2012 SP - 4 PB - CSIRO Publishing for the Australian Society of Exploration Geophysicists, Collingwood, Victoria VL - 2012 IS - 1 KW - mining KW - geologic hazards KW - underground mining KW - Bayesian analysis KW - statistical analysis KW - data processing KW - mathematical models KW - layered earth model KW - inverse problem KW - sedimentary rocks KW - seismicity KW - seismic risk KW - natural hazards KW - velocity KW - focus KW - static corrections KW - heterogeneity KW - induced earthquakes KW - earthquakes KW - accuracy KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1026860977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ASEG+Extended+Abstracts&rft.atitle=Velocity+model+determination+for+accurate+location+of+mining-induced+seismic+events&rft.au=King%2C+Andrew%3BAnonymous&rft.aulast=King&rft.aufirst=Andrew&rft.date=2012-01-01&rft.volume=2012&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=ASEG+Extended+Abstracts&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - ASEG 2012; 22nd international geophysical conference and exhibition N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Produced under license from the Commonwealth of Australia as represented by Geoscience Australia, Canberra, ACT, Australia N1 - Date revised - 2012-01-01 N1 - Number of references - 6 N1 - PubXState - Victoria N1 - Document feature - illus. N1 - SuppNotes - Summary also published in Preview, Vol. 156, Feb. 2012, p. 103-104 N1 - Last updated - 2012-07-19 N1 - CODEN - #07605 N1 - SubjectsTermNotLitGenreText - accuracy; Bayesian analysis; data processing; earthquakes; focus; geologic hazards; heterogeneity; induced earthquakes; inverse problem; layered earth model; mathematical models; mining; natural hazards; sedimentary rocks; seismic risk; seismicity; static corrections; statistical analysis; underground mining; velocity ER - TY - JOUR T1 - Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania AN - 1024666650; 16862535 AB - Background: Nitrate is a widespread contaminant of drinking water supplies, especially in agricultural areas. Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid function. Methods: We assessed the relation of estimated nitrate levels in well water supplies with thyroid health in a cohort of 2,543 Old Order Amish residing in Lancaster, Chester, and Lebanon counties in Pennsylvania for whom thyroid stimulating hormone (TSH) levels were measured during 1995-2008. Nitrate measurement data (1976-2006) for 3,613 wells in the study area were obtained from the U.S. Geological Survey and we used these data to estimate concentrations at study participants' residences using a standard linear mixed effects model that included hydrogeological covariates and kriging of the wells' residuals. Nitrate levels estimated by the model ranged from 0.35 mg/L to 16.4 mg/L N-NO sub(3) super(-), with a median value of 6.5 mg/L, which was used as the cutpoint to define high and low nitrate exposure. In a validation analysis of the model, we calculated that the sensitivity of the model was 67% and the specificity was 93%. TSH levels were used to define the following outcomes: clinical hyperthyroidism (n = 10), clinical hypothyroidism (n = 56), subclinical hyperthyroidism (n = 25), and subclinical hypothyroidism (n = 228). Results: In women, high nitrate exposure was significantly associated with subclinical hypothyroidism (OR = 1.60; 95% CI: 1.11-2.32). Nitrate was not associated with subclinical thyroid disease in men or with clinical thyroid disease in men or women. Conclusions: Although these data do not provide strong support for an association between nitrate in drinking water and thyroid health, our results do suggest that further exploration of this hypothesis is warranted using studies that incorporate individual measures of both dietary and drinking water nitrate intake. JF - Environmental Health (London) AU - Aschebrook-Kilfoy, Briseis AU - Heltshe, Sonya L AU - Nuckols, John R AU - Sabra, Mona M AU - Shuldiner, Alan R AU - Mitchell, Braxton D AU - Airola, Matt AU - Holford, Theodore R AU - Zhang, Yawei AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 6 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 11 IS - 1 SN - 1476-069X, 1476-069X KW - Health & Safety Science Abstracts KW - Diets KW - Nitrates KW - iodides KW - USA, Pennsylvania KW - geological surveys KW - Lebanon KW - Thyroid KW - Water wells KW - Drinking water KW - Water supplies KW - Hormones KW - H 3000:Environment and Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024666650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+%28London%29&rft.atitle=Modeled+nitrate+levels+in+well+water+supplies+and+prevalence+of+abnormal+thyroid+conditions+among+the+Old+Order+Amish+in+Pennsylvania&rft.au=Aschebrook-Kilfoy%2C+Briseis%3BHeltshe%2C+Sonya+L%3BNuckols%2C+John+R%3BSabra%2C+Mona+M%3BShuldiner%2C+Alan+R%3BMitchell%2C+Braxton+D%3BAirola%2C+Matt%3BHolford%2C+Theodore+R%3BZhang%2C+Yawei%3BWard%2C+Mary+H&rft.aulast=Aschebrook-Kilfoy&rft.aufirst=Briseis&rft.date=2012-01-01&rft.volume=11&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+%28London%29&rft.issn=1476069X&rft_id=info:doi/10.1186%2F1476-069X-11-6 L2 - http://www.ehjournal.net/content/11/1/6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Number of references - 33 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Diets; Nitrates; iodides; geological surveys; Thyroid; Water wells; Drinking water; Hormones; Water supplies; USA, Pennsylvania; Lebanon DO - http://dx.doi.org/10.1186/1476-069X-11-6 ER - TY - JOUR T1 - Rural-Urban Trends and Patterns in Cervical Cancer Mortality, Incidence, Stage, and Survival in the United States, 1950-2008 AN - 1023031560; 201204523 AB - This study examined disparities in cervical cancer mortality rates among US women in metropolitan and non-metropolitan areas from 1950 through 2007. Inequalities in incidence, stage of disease at diagnosis, and patient survival were analyzed during 2000-2008. Age-adjusted mortality, incidence, and 5-year relative survival rates were calculated for women in metropolitan and non-metropolitan areas, and differences in relative risks were tested for statistical significance. Log-linear regression was used to analyze annual rates of change in mortality over time. During the last five decades, women in non-metropolitan areas had significantly higher cervical cancer mortality than those in metropolitan areas. Disparities persisted against a backdrop of consistently declining mortality rates. Throughout 1969-2007, both white and black women in non-metropolitan areas maintained significantly higher cervical cancer mortality rates than their metropolitan counterparts. Among black women, cervical cancer mortality declined at a faster pace in metropolitan than in non-metropolitan areas. In both metropolitan and non-metropolitan areas, black women had twice the mortality rate of white women. During 2000-2008, white, black, and American Indian women in non-metropolitan areas had significantly higher cervical cancer incidence rates than their metropolitan counterparts. Survival rates were significantly lower in non-metropolitan areas, particularly among rural black women. The 5-year survival rate for black women diagnosed with cervical cancer was 50.8% in non-metropolitan areas, compared with 60.2% for black women and 71.0% for white women in metropolitan areas. Disparities in survival existed after controlling for disease stage. Rural-urban disparities in cervical cancer have persisted despite steep declines in incidence and mortality rates. Adapted from the source document. JF - Journal of Community Health AU - Singh, Gopal K AD - US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA gsingh@hrsa.gov Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 217 EP - 223 PB - Springer, New York NY VL - 37 IS - 1 SN - 0094-5145, 0094-5145 KW - Mortality Rates KW - Black White Relations KW - Inequality KW - United States of America KW - Diseases KW - Racial Differences KW - Females KW - Metropolitan Areas KW - Cancer KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023031560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Rural-Urban+Trends+and+Patterns+in+Cervical+Cancer+Mortality%2C+Incidence%2C+Stage%2C+and+Survival+in+the+United+States%2C+1950-2008&rft.au=Singh%2C+Gopal+K&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2012-01-01&rft.volume=37&rft.issue=1&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-011-9439-6 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Mortality Rates; Females; Cancer; Racial Differences; Metropolitan Areas; Black White Relations; United States of America; Diseases; Inequality DO - http://dx.doi.org/10.1007/s10900-011-9439-6 ER - TY - JOUR T1 - Measuring juvenile delinquency: How do self-reports compare with official police statistics? AN - 1023029773; 201226697 AB - The accuracy of measuring the prevalence of delinquency by means of self-reported questionnaires is difficult to evaluate. This study assesses the differential validity of self-reported delinquency in adolescents and, more specifically, self-reported police contacts because of suspected misconduct. This study was conducted as part of the Rotterdam Youth Monitor, a youth health surveillance system. Self-report data of pupils (mainly 12-15 years old) in the first or third grade of secondary school in the school years 2007-8 and 2008-9 (n = 23,914) were merged with police data. Of the pupils registered as a suspect, 62 percent admitted to having been interrogated at the police station. However, there were differences between groups. Multivariate analysis showed that Moroccan pupils and first-grade pupils were more likely to give an invalid response. Pupils who were registered for theft, vandalism or assault were more likely to give a valid response, whereas pupils who were registered for an offence involving fireworks were more likely to give an invalid response. We conclude that using only self-reported data to measure delinquency in an ethnically diverse population results in substantial bias. It is advisable to use multiple sources to measure the prevalence of delinquency. [Reprinted by permission of Sage Publications, Ltd., copyright holder.] JF - European Journal of Criminology AU - van Batenburg-Eddes, Tamara AU - Butte, Dick AU - van de Looij-Jansen, Petra AU - Schiethart, Wiet AU - Raat, Hein AU - de Waart, Frouwkje AU - Jansen, Wilma AD - Rotterdam-Rijnmond Public Health Service, The Netherlands Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 23 EP - 37 PB - Sage Publications, London UK VL - 9 IS - 1 SN - 1477-3708, 1477-3708 KW - adolescents delinquency validity KW - Racism KW - Rotterdam, Netherlands KW - Juvenile Delinquency KW - Assault KW - Police KW - Students KW - Adolescents KW - Secondary Schools KW - Youth KW - article KW - 2147: social problems and social welfare; sociology of crime UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023029773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Criminology&rft.atitle=Measuring+juvenile+delinquency%3A+How+do+self-reports+compare+with+official+police+statistics%3F&rft.au=van+Batenburg-Eddes%2C+Tamara%3BButte%2C+Dick%3Bvan+de+Looij-Jansen%2C+Petra%3BSchiethart%2C+Wiet%3BRaat%2C+Hein%3Bde+Waart%2C+Frouwkje%3BJansen%2C+Wilma&rft.aulast=van+Batenburg-Eddes&rft.aufirst=Tamara&rft.date=2012-01-01&rft.volume=9&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Criminology&rft.issn=14773708&rft_id=info:doi/10.1177%2F1477370811421644 LA - English DB - Sociological Abstracts N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Students; Police; Youth; Racism; Assault; Rotterdam, Netherlands; Secondary Schools; Adolescents; Juvenile Delinquency DO - http://dx.doi.org/10.1177/1477370811421644 ER - TY - JOUR T1 - Human exposures to pesticides in the United States. AN - 1022379524; 22732070 AB - Pesticides are used in most homes, businesses, and farms to control a variety of pests, including insects, weeds, fungi, rodents, and even microbial organisms. Inappropriate use of pesticides can lead to adverse effects to humans and the environment. This study provides updated information on the magnitude of adverse pesticide exposures in the United States. Data on pesticide exposure were obtained from calls to poison control centers (PCCs) reported by the American Association of Poison Control Centers. Estimates of emergency department visits, hospitalizations, and health care costs were reported by the Agency for Healthcare Research and Quality (AHRQ), and deaths from pesticide poisonings reported by the Centers for Disease Control and Prevention (CDC) WONDER (Wide-ranging Online Data for Epidemiologic Research). An average of 23 deaths occur each year with pesticides as the underlying cause of death, most due to suicidal ingestions. An average of 130,136 calls to poison control centers were reported from 2006 to 2010, with an average of 20,116 cases (17.8%) treated in health care facilities annually. AHQR reported an annual average of 7385 emergency room visits during 2006 to 2008, and 1419 annual hospitalizations during 2005 to 2009. Excluding cost from lost work time, hospital physician fees, and pesticide-induced cancers, the annual national cost associated with pesticide exposures was estimated as nearly $200 million USD based on data from emergency department visits, hospitalizations, and for deaths. Pesticide exposures remain a significant public health issue. Health care providers, cooperative extension agents, and pesticide manufactures can help prevent exposures by increasing education of parents and workers, encourage use of less toxic agents, and encourage the practice of integrated pest management. JF - Journal of agromedicine AU - Langley, Ricky L AU - Mort, Sandra Amiss AD - North Carolina Department of Health and Human Services, Division of Public Health, Raleigh, North Carolina 27699-1912, USA. rick.langley@dhhs.nc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 300 EP - 315 VL - 17 IS - 3 KW - Pesticides KW - 0 KW - Index Medicus KW - United States KW - Young Adult KW - Public Health KW - Humans KW - Emergency Service, Hospital -- statistics & numerical data KW - Child KW - Hospitalization -- statistics & numerical data KW - Adolescent KW - Health Care Costs KW - Poison Control Centers -- statistics & numerical data KW - Pesticides -- poisoning KW - Poisoning -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1022379524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Human+exposures+to+pesticides+in+the+United+States.&rft.au=Langley%2C+Ricky+L%3BMort%2C+Sandra+Amiss&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2012-01-01&rft.volume=17&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F1059924X.2012.688467 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-11-30 N1 - Date created - 2012-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/1059924X.2012.688467 ER - TY - JOUR T1 - Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure AN - 1017966797; 16575159 AB - OBJECTIVES: Prior investigations identified an association between airborne cadmium and lung cancer but questions remain regarding confounding by arsenic, a well-established lung carcinogen. METHODS: A cadmium smelter population exhibiting excess lung cancer was re-analysed using a retrospective exposure assessment for arsenic (As), updated mortality (1940-2002), a revised cadmium (Cd) exposure matrix and improved work history information. RESULTS: Cumulative exposure metrics for both cadmium and arsenic were strongly associated making estimation of their independent effects difficult. Standardised mortality ratios (SMRs) were modelled with Poisson regression with the contribution of arsenic to lung cancer risk constrained by exposure-response estimates previously reported. The results demonstrate (1) a statistically significant effect of Cd independent of As (SMR=3.2 for 10 mg-year/m3 Cd, p=0.012), (2) a substantial healthy worker effect for lung cancer (for unexposed workers, SMR=0.69) and (3) a large deficit in lung cancer mortality among Hispanic workers (SMR=0.27, p=0.009), known to have low lung cancer rates. A supralinear dose-rate effect was observed (contribution to risk with increasing exposure intensity has declining positive slope). Lung cancer mortality was somewhat better predicted using a cadmium burden metric with a half-life of about 20-25 years. CONCLUSIONS: These findings support an independent effect for cadmium in risk of lung cancer mortality. 1/1000 excess lifetime risk of lung cancer death is predicted from an airborne exposure of about 2.4 mu g/m3 Cd. JF - Occupational and Environmental Medicine AU - Park, Robert M AU - Stayner, Leslie T AU - Petersen, Martin R AU - Finley-Couch, Melissa AU - Hornung, Richard AU - Rice, Carol AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio, USA Y1 - 2012 PY - 2012 DA - 2012 SP - 303 EP - 309 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 69 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Arsenic KW - Dose-response effects KW - Carcinogens KW - Smelters KW - Cancer KW - Occupational exposure KW - Ethnic groups KW - Lung cancer KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Cadmium+and+lung+cancer+mortality+accounting+for+simultaneous+arsenic+exposure&rft.au=Park%2C+Robert+M%3BStayner%2C+Leslie+T%3BPetersen%2C+Martin+R%3BFinley-Couch%2C+Melissa%3BHornung%2C+Richard%3BRice%2C+Carol&rft.aulast=Park&rft.aufirst=Robert&rft.date=2012-01-01&rft.volume=69&rft.issue=5&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mortality; Arsenic; Dose-response effects; Carcinogens; Smelters; Ethnic groups; Occupational exposure; Cancer; Lung cancer ER - TY - JOUR T1 - Animal-related injuries resulting in emergency department visits and hospitalizations in the United States, 2006-2008 AN - 1011215928; 16579081 AB - This paper presents information on emergency department (ED) visits and hospitalizations resulting from an animal-caused injury from 2006 to 2008 using data collected from the Agency for Healthcare Research and Quality. Information on the number of ED visits and hospitalizations from adverse animal encounters, the types of injuries resulting from such encounters, and the therapeutic procedures performed to treat injured persons from bites or stings caused by various species of animals are presented. The economic costs of animal-caused injuries also are discussed. Over 1 million hospital ED visits and 48,000 hospitalizations were reported annually in the United States due to an animal-caused injury during this time period. Infections resulting from non-venomous animal bites were the major cause of hospital admissions. The estimated cost of these visits, excluding physician fees during hospitalization, exceeded $2 billion annually. Many animal-related injuries can be prevented if advice from wildlife agencies or the Centers for Disease Control and Prevention were heeded. JF - Human-Wildlife Interactions AU - Langley, R L AD - North Carolina Department of Health and Human Services, 1912 Mail Service Center, Raleigh, NC 27699-1912, USA, rick.langley@dhhs.nc.gov Y1 - 2012 PY - 2012 DA - 2012 SP - 123 EP - 136 VL - 6 IS - 1 SN - 2155-3858, 2155-3858 KW - Animal Behavior Abstracts; Ecology Abstracts; Sustainability Science Abstracts KW - Bites KW - Data processing KW - Disease control KW - Economics KW - Health care KW - Hospitals KW - Infection KW - Injuries KW - Stings KW - Wildlife KW - bites KW - emergency medical services KW - fees KW - infection KW - USA KW - Y 25150:General/Miscellaneous KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011215928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human-Wildlife+Interactions&rft.atitle=Animal-related+injuries+resulting+in+emergency+department+visits+and+hospitalizations+in+the+United+States%2C+2006-2008&rft.au=Langley%2C+R+L&rft.aulast=Langley&rft.aufirst=R&rft.date=2012-01-01&rft.volume=6&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Human-Wildlife+Interactions&rft.issn=21553858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Data processing; Stings; Injuries; Bites; Wildlife; Economics; Disease control; Infection; Hospitals; Health care; bites; infection; fees; emergency medical services; USA ER - TY - JOUR T1 - Affective prosody labeling in youths with bipolar disorder or severe mood dysregulation AN - 1010707830; 201208177 AB - Background: Accurate identification of nonverbal emotional cues is essential to successful social interactions, yet most research is limited to emotional face expression labeling. Little research focuses on the processing of emotional prosody, or tone of verbal speech, in clinical populations. Methods: Using the Diagnostic Analysis of Nonverbal Accuracy, the current study examined whether youths with pediatric-onset bipolar disorder (BD) and/or those with chronic and severe irritability (i.e. the severe mood dysregulation phenotype) are impaired in their ability to identify the emotional prosody of a spoken sentence with neutral content. Results: Youths with severe mood dysregulation (n=67) performed more poorly than healthy comparison children (n=57), even when the sample was limited to unmedicated patients. Medicated BD youths (n=52) exhibited impairment relative to healthy comparison children. No interactions between group and emotion were observed, suggesting that emotional prosody labeling problems may represent a general deficit in chronically irritable youths and in medicated youths with BD. Conclusion: In concert with previously documented facial emotion labeling deficits, difficulties ascertaining the correct emotional tone of a spoken sentence may contribute to emotion dysregulation in chronically irritable children, and possibly also in youths with BD. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Deveney, Christen M AU - Brotman, Melissa A AU - Decker, Ann Marie AU - Pine, Daniel S AU - Leibenluft, Ellen AD - Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA Y1 - 2012///0, PY - 2012 DA - 0, 2012 SP - 262 EP - 270 PB - Blackwell Publishing, Oxford UK VL - 53 IS - 3 SN - 0021-9630, 0021-9630 KW - Chronically KW - Bipolar affective disorder KW - Moods KW - Young people KW - Children KW - Prosody KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Affective+prosody+labeling+in+youths+with+bipolar+disorder+or+severe+mood+dysregulation&rft.au=Deveney%2C+Christen+M%3BBrotman%2C+Melissa+A%3BDecker%2C+Ann+Marie%3BPine%2C+Daniel+S%3BLeibenluft%2C+Ellen&rft.aulast=Deveney&rft.aufirst=Christen&rft.date=2012-01-01&rft.volume=53&rft.issue=3&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2011.02482.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Young people; Prosody; Moods; Children; Bipolar affective disorder; Chronically DO - http://dx.doi.org/10.1111/j.1469-7610.2011.02482.x ER - TY - JOUR T1 - Pharmacokinetics of Bisphenol A in neonatal and adult CD-1 mice: Inter-species comparisons with Sprague-Dawley rats and rhesus monkeys AN - 911154226; 15965319 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure at levels largely below 1 mu g/kg bw/d. The current study used LC/MS/MS to measure serum pharmacokinetics of unconjugated (active) and conjugated (inactive) BPA in adult and neonatal CD-1 mice by oral and subcutaneous (SC) injection routes. Deuterated BPA was used to avoid issues of background contamination. Significant inverse relationships were observed between postnatal age and measures of internal exposures (Cmax) to unconjugated BPA after oral administration. Phase II conjugation, area under the time-concentration curve (AUC), and elimination half-time of unconjugated BPA were also inversely related to age. In postnatal day (PND) 3 mice, the combination of under-developed Phase II metabolism, rapid absorption, and slow elimination kinetics led to equivalent internal exposures for unconjugated BPA from oral and SC routes; however, maturing metabolic capabilities in PND 10 and older mice, led to large and significant route effects. The significant inverse age-related developmental profiles from PND 3 through adulthood for unconjugated BPA internal exposure metrics from oral administration to CD-1 mice and Sprague-Dawley rats were remarkably similar; however, the developmental profile was quite different for neonatal rhesus monkeys in which small insignificant age-related differences were observed. These results suggest that an adverse effect from BPA observed in rodent models, attributable to exposure during a discrete time period of neonatal development, would be less likely for comparable neonatal primate dosing based on internal dosimetry. On the other hand in all adults of all species studied, including humans, a low oral dose of BPA produced similarly small internal exposures for the unconjugated form, reflecting the dominant effect of presystemic Phase II metabolism. JF - Toxicology Letters AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States, daniel.doerge@fda.hhs.gov Y1 - 2011/12/15/ PY - 2011 DA - 2011 Dec 15 SP - 298 EP - 305 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 207 IS - 3 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Bisphenol A KW - Estrogen receptors KW - Mass spectrometry KW - Pharmacokinetics KW - Age KW - Food KW - Dosimetry KW - Oral administration KW - Metabolites KW - Food contamination KW - Primates KW - Urine KW - Kinetics KW - Macaca mulatta KW - Neonates KW - Plastics KW - polycarbonate KW - Metabolism KW - Side effects KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Pharmacokinetics+of+Bisphenol+A+in+neonatal+and+adult+CD-1+mice%3A+Inter-species+comparisons+with+Sprague-Dawley+rats+and+rhesus+monkeys&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2011-12-15&rft.volume=207&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2011.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Food; Dosimetry; Oral administration; Metabolites; Food contamination; Pharmacokinetics; Bisphenol A; Urine; Kinetics; Plastics; Neonates; Side effects; Metabolism; polycarbonate; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.toxlet.2011.09.020 ER - TY - JOUR T1 - Hair dye use and risk of bladder cancer in the New England bladder cancer study AN - 1017962672; 16689667 AB - Aromatic amine components in hair dyes and polymorphisms in genes that encode enzymes responsible for hair dye metabolism may be related to bladder cancer risk. We evaluated the association between hair dye use and bladder cancer risk and effect modification by N-acetyltransferase-1 (NAT1), NAT2, glutathione S-transferase Mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) genotypes in a population-based case-control study of 1193 incident cases and 1418 controls from Maine, Vermont and New Hampshire enrolled between 2001 and 2004. Individuals were interviewed in person using a computer-assisted personal interview to assess hair dye use and information on potential confounders and effect modifiers. No overall association between age at first use, year of first use, type of product, color, duration or number of applications of hair dyes and bladder cancer among women or men was apparent, but increased risks were observed in certain subgroups. Women who used permanent dyes and had a college degree, a marker of socioeconomic status, had an increased risk of bladder cancer [odds ratio (OR) = 3.3, 95% confidence interval (CI): 1.2-8.9]. Among these women, we found an increased risk of bladder cancer among exclusive users of permanent hair dyes who had NAT2 slow acetylation phenotype (OR = 7.3, 95% CI: 1.6-32.6) compared to never users of dye with NAT2 rapid/intermediate acetylation phenotype. Although we found no relation between hair dye use and bladder cancer risk in women overall, we detected evidence of associations and gene-environment interaction with permanent hair dye use; however, this was limited to educated women. These results need confirmation with larger numbers, requiring pooling data from multiple studies. JF - International Journal of Cancer AU - Koutros, Stella AU - Silverman, Debra T AU - Baris, Dalsu AU - Zahm, Shelia Hoar AU - Morton, Lindsay M AU - Colt, Joanne S AU - Hein, David W AU - Moore, Lee E AU - Johnson, Alison AU - Schwenn, Molly AU - Cherala, Sai AU - Schned, Alan AU - Doll, Mark A AU - Rothman, Nathaniel AU - Karagas, Margaret R AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, koutross@mail.nih.gov Y1 - 2011/12/15/ PY - 2011 DA - 2011 Dec 15 SP - 2894 EP - 2904 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 129 IS - 12 SN - 1097-0215, 1097-0215 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Amines KW - Cancer KW - Dyes KW - Enzymes KW - Hair KW - Metabolism KW - Socioeconomics KW - Urinary bladder KW - urinary bladder KW - USA, New England KW - USA, New Hampshire KW - USA, Maine KW - USA, Vermont KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Hair+dye+use+and+risk+of+bladder+cancer+in+the+New+England+bladder+cancer+study&rft.au=Koutros%2C+Stella%3BSilverman%2C+Debra+T%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+Hoar%3BMorton%2C+Lindsay+M%3BColt%2C+Joanne+S%3BHein%2C+David+W%3BMoore%2C+Lee+E%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BCherala%2C+Sai%3BSchned%2C+Alan%3BDoll%2C+Mark+A%3BRothman%2C+Nathaniel%3BKaragas%2C+Margaret+R&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2011-12-15&rft.volume=129&rft.issue=12&rft.spage=2894&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=10970215&rft_id=info:doi/10.1002%2Fijc.26245 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ijc.26245/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - urinary bladder; Age; Dyes; Urinary bladder; Socioeconomics; Enzymes; Amines; Hair; Metabolism; Cancer; USA, New England; USA, Maine; USA, New Hampshire; USA, Vermont DO - http://dx.doi.org/10.1002/ijc.26245 ER - TY - CPAPER T1 - The Entire Primary Sequence of Factor VIII Is Synthesized As Two Polypeptide Chains in Hemophilia A Patients with the Intron-22-Inversion T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1313028661; 6121946 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Pandey, Gouri AU - Garfield, Susan AU - Curran, Joanne AU - Moses, Eric AU - Kimchi-Sarfaty, Chava AU - Yanover, Chen AU - Howard, Tom AU - Sauna, Zuben Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - hemophilia KW - Coagulation factors KW - Hemophilia KW - Polypeptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313028661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=The+Entire+Primary+Sequence+of+Factor+VIII+Is+Synthesized+As+Two+Polypeptide+Chains+in+Hemophilia+A+Patients+with+the+Intron-22-Inversion&rft.au=Pandey%2C+Gouri%3BGarfield%2C+Susan%3BCurran%2C+Joanne%3BMoses%2C+Eric%3BKimchi-Sarfaty%2C+Chava%3BYanover%2C+Chen%3BHoward%2C+Tom%3BSauna%2C+Zuben&rft.aulast=Pandey&rft.aufirst=Gouri&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Expression of the Light Chain of Coagulation Factor VIII in Insect Cells T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312998808; 6123212 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Shestopal, Svetlana AU - Kurasawa, James AU - Lee, Timothy AU - Sarafanov, Andrey Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Coagulation KW - Insects KW - Light chains KW - Insect cells KW - Coagulation factor VIII KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Expression+of+the+Light+Chain+of+Coagulation+Factor+VIII+in+Insect+Cells&rft.au=Shestopal%2C+Svetlana%3BKurasawa%2C+James%3BLee%2C+Timothy%3BSarafanov%2C+Andrey&rft.aulast=Shestopal&rft.aufirst=Svetlana&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Single and Codon-Optimized Synonymous Mutations in Factor IX Alter Protein Properties T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312988025; 6080720 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Tseng, Sandra AU - Katagiri, Nobuko AU - Simhadri, Vijaya AU - Jha, Sujata AU - Edwards, Nathan AU - Kopelman, David AU - Sauna, Zuben AU - Stern, Michael AU - Zichel, Michael AU - Komar, Anton AU - Kimchi-Sarfaty, Chava Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Mutation KW - Coagulation factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312988025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Single+and+Codon-Optimized+Synonymous+Mutations+in+Factor+IX+Alter+Protein+Properties&rft.au=Tseng%2C+Sandra%3BKatagiri%2C+Nobuko%3BSimhadri%2C+Vijaya%3BJha%2C+Sujata%3BEdwards%2C+Nathan%3BKopelman%2C+David%3BSauna%2C+Zuben%3BStern%2C+Michael%3BZichel%2C+Michael%3BKomar%2C+Anton%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Tseng&rft.aufirst=Sandra&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Temperature Cycling Improves In Vivo recovery of Cold Stored Human Platelets T2 - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AN - 1312952840; 6083418 JF - 53rd Annual Meeting of the American Society of Hematology (ASH 2011) AU - Xu, Fei AU - Gelderman-Fuhrmann, Monique AU - Farrell, John AU - Vostal, Jaroslav Y1 - 2011/12/10/ PY - 2011 DA - 2011 Dec 10 KW - Temperature effects KW - Platelets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312952840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.atitle=Temperature+Cycling+Improves+In+Vivo+recovery+of+Cold+Stored+Human+Platelets&rft.au=Xu%2C+Fei%3BGelderman-Fuhrmann%2C+Monique%3BFarrell%2C+John%3BVostal%2C+Jaroslav&rft.aulast=Xu&rft.aufirst=Fei&rft.date=2011-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+American+Society+of+Hematology+%28ASH+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://ash.confex.com/ash/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - New neutralizing antibody epitopes in hepatitis C virus envelope glycoproteins are revealed by dissecting peptide recognition profiles AN - 912924599; 16137696 AB - One of the greatest challenges to HCV vaccine development is the induction of effective immune responses using recombinant proteins or vectors. In order to better understand which vaccine-induced antibodies contribute to neutralization of HCV the quality of polyclonal anti-E1E2 antibody responses in immunized mice and chimpanzees was assessed at the level of epitope recognition using peptide scanning and neutralization of chimeric 1a/2a, 1b/2a and 2a HCVcc after blocking or affinity elution of specific antibodies. Mice and chimpanzees were immunized with genotype 1a (H77) HCV gpE1E2; all samples contained cross-neutralizing antibody against HCVcc. By functionally dissecting the polyclonal immune responses we identified three new regions important for neutralization within E1 (aa264-318) and E2 (aa448-483 and aa496-515) of the HCV glycoproteins, the third of which (aa496-515) is highly conserved (85-95%) amongst genotypes. Antibodies to aa496-515 were isolated by affinity binding and elution from the serum of a vaccinated chimpanzee and found to specifically neutralize chimeric 1a/2a, 1b/2a and 2a HCVcc. IC50 titres (IgG ng/mL) for the aa496-515 eluate were calculated as 142.1, 239.37 and 487.62 against 1a/2a, 1b/2a and 2a HCVcc, respectively. Further analysis demonstrated that although antibody to this new, conserved neutralization epitope is efficiently induced with recombinant proteins in mice and chimpanzees; it is poorly induced during natural infection in patients and chimpanzees (7 out of 68 samples positive) suggesting the epitope is poorly presented to the immune system in the context of the viral particle. These findings have important implications for the development of HCV vaccines and strategies designed to protect against heterologous viruses. The data also suggest that recombinant or synthetic antigens may be more efficient at inducing neutralizing antibodies to certain epitopes and that screening virally infected patients may not be the best approach for finding new cross-reactive epitopes. JF - Vaccine AU - Kachko, Alla AU - Kochneva, Galina AU - Sivolobova, Galina AU - Grazhdantseva, Antonina AU - Lupan, Tatyana AU - Zubkova, Iryna AU - Wells, Frances AU - Merchlinsky, Michael AU - Williams, Ollie AU - Watanabe, Hisayoshi AU - Ivanova, Alla AU - Shvalov, Aleksander AU - Loktev, Valeriy AU - Netesov, Sergei AU - Major, Marian E AD - Laboratory of Hepatitis Viruses, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA, alla.kachko@fda.hhs.gov Y1 - 2011/12/09/ PY - 2011 DA - 2011 Dec 09 SP - 69 EP - 77 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 30 IS - 1 SN - 0264-410X, 0264-410X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Data processing KW - Envelopes KW - Epitopes KW - Genotypes KW - Glycoproteins KW - Immune response KW - Immune system KW - Immunoglobulin G KW - Infection KW - Scanning KW - Vaccines KW - Pan troglodytes KW - Hepatitis C virus KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912924599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=New+neutralizing+antibody+epitopes+in+hepatitis+C+virus+envelope+glycoproteins+are+revealed+by+dissecting+peptide+recognition+profiles&rft.au=Kachko%2C+Alla%3BKochneva%2C+Galina%3BSivolobova%2C+Galina%3BGrazhdantseva%2C+Antonina%3BLupan%2C+Tatyana%3BZubkova%2C+Iryna%3BWells%2C+Frances%3BMerchlinsky%2C+Michael%3BWilliams%2C+Ollie%3BWatanabe%2C+Hisayoshi%3BIvanova%2C+Alla%3BShvalov%2C+Aleksander%3BLoktev%2C+Valeriy%3BNetesov%2C+Sergei%3BMajor%2C+Marian+E&rft.aulast=Kachko&rft.aufirst=Alla&rft.date=2011-12-09&rft.volume=30&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2011.10.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2013-04-05 N1 - SubjectsTermNotLitGenreText - Envelopes; Data processing; Scanning; Immune system; Immunoglobulin G; Glycoproteins; Genotypes; Immune response; Vaccines; Infection; Epitopes; Hepatitis C virus; Pan troglodytes DO - http://dx.doi.org/10.1016/j.vaccine.2011.10.045 ER - TY - JOUR T1 - GOTTLIEB: PRIORITIZE GENERIC SUPPLEMENTAL APPLICATIONS TO STEM SHORTAGES AN - 913045463 AB - A former FDA, and CMS, adviser told House Oversight subcommittee members that the agency should prioritize all supplemental applications for generic injectable drugs, not just those that are in shortage, to prevent future drug shortages and that generic drug user fees could support this effort. JF - Inside Washington Publishers' Inside CMS AU - Week, FDA Y1 - 2011/12/08/ PY - 2011 DA - 2011 Dec 08 CY - Arlington PB - Inside Washington Publishers VL - 14 IS - 25 KW - Health Facilities And Administration KW - Generic drugs KW - Manufacturing KW - Pharmaceutical industry KW - Prescription drugs KW - Manufacturers KW - Legislators KW - Problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/913045463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthmanagement&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Inside+Washington+Publishers%27+Inside+CMS&rft.atitle=GOTTLIEB%3A+PRIORITIZE+GENERIC+SUPPLEMENTAL+APPLICATIONS+TO+STEM+SHORTAGES&rft.au=Week%2C+FDA&rft.aulast=Week&rft.aufirst=FDA&rft.date=2011-12-08&rft.volume=14&rft.issue=25&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Inside+Washington+Publishers%27+Inside+CMS&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Inside Washington Publishers Dec 8, 2011 N1 - Last updated - 2011-12-30 ER - TY - GEN T1 - What Works to Prevent or Reduce Internalizing Problems or Socio-Emotional Difficulties in Adolescents: Lessons from Experimental Evaluations of Social Interventions. Fact Sheet. Publication #2011-34 AN - 964180103; ED528672 AB - Left untreated, internalizing problems, such as a depressive or anxious mood, negative self-perceptions, and emotional distress, can undermine one's ability to succeed in school, live a healthy lifestyle, form and maintain close relationships with others, and, in general, accomplish life goals. When internalizing problems are experienced daily for at least two weeks, a psychiatric disorder--such as a major depressive disorder or a generalized anxiety disorder--may be underlying these problems. Among 13- to 18-year-olds, the lifetime prevalence of anxiety disorders is about 32 percent and the lifetime prevalence of mood disorders is about 14 percent. Among the population of U.S. adolescents aged 12 to 17, about 8 percent (about 2 million) had a major depressive episode (moderate to severe depression lasting at least two weeks) during the past year. Half of all adult lifetime cases of mental disorders emerge by age 14 years. Depression and other mood disorders increase risk for suicide, which is the third leading cause of death among U.S. adolescents aged 15 to 19. Overall, the cost of mental health problems has been estimated at about 2.5 percent of our Gross National Product, with $73.4 billion (1997 dollars) spent solely on the treatment of mental illness. This synthesis presents lessons learned from 37 random-assignment social intervention programs for adolescents that are designed to prevent or treat internalizing problems. Programs were identified by searching LINKS (Lifecourse Interventions to Nurture Kids Successfully), Child Trends' online database of rigorously-evaluated social interventions for children and youth. All interventions included in LINKS are social interventions evaluated using random assignment, intent-to-treat evaluations. Note that although this synthesis reviews treatment approaches, it does not review biomedical studies as these studies are not included in LINKS. Findings from this literature review suggest that social interventions to address internalizing problems are most effective when they teach adolescents how to cope with negative thoughts and emotions, solve problems, and interact effectively with others. Therapeutic approaches, such as family therapy, group therapy, individual therapy, and treatment-focused, school-based approaches appear to be effective. Mixed results were found for programs including activities to increase self-esteem and programs directed at non-clinical populations of youth. Among a handful of studies reviewed, programs with a mentoring component and programs targeting only females, although found to improve certain outcomes, were not found to ameliorate internalizing symptoms. (Contains 1 table, 10 footnotes, and 14 endnotes.) [This paper is a product of a co-partnership with the National Adolescent Health Information and Innovation Center (NAHIIC) at the University of California, San Francisco. Additional funding was provided by the Alexander and Margaret Stewart Trust Foundation.] AU - Terzian, Mary AU - Hamilton, Katie AU - Ericson, Sara Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 11 PB - Child Trends. 4301 Connecticut Avenue NW Suite 350, Washington, DC 20008. KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Depression (Psychology) KW - Individual Counseling KW - Intervention KW - Suicide KW - Problem Solving KW - Emotional Disturbances KW - Family Counseling KW - Self Esteem KW - Anxiety Disorders KW - Coping KW - Shyness KW - Posttraumatic Stress Disorder KW - Adolescents KW - Group Counseling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964180103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aeric&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=&rft.atitle=What+Works+to+Prevent+or+Reduce+Internalizing+Problems+or+Socio-Emotional+Difficulties+in+Adolescents%3A+Lessons+from+Experimental+Evaluations+of+Social+Interventions.+Fact+Sheet.+Publication+%232011-34&rft.au=Terzian%2C+Mary%3BHamilton%2C+Katie%3BEricson%2C+Sara&rft.aulast=Terzian&rft.aufirst=Mary&rft.date=2011-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Evaluating the Dilution of Wastewater Treatment Plant Effluent and Viral Impacts on Shellfish Growing Areas in Mobile Bay, Alabama AN - 954659543; 16386765 AB - The U.S. Food and Drug Administration (FDA) provides guidance to state shellfish control authorities on establishing prohibitive closure zones in proximity to wastewater treatment plant (WWTP) discharges with the purpose of minimizing the exposure of molluscan shellfish to health hazards posed by bacterial and viral pathogens present in wastewater effluents. For more than 25 years, the FDA has recognized conditional area management as an option to minimize the size of a prohibitive closure zone, and to enlarge the size and productivity of shellfish growing areas. To use this option, the FDA has recommended achieving a 1,000:1 dilution of effluent within the perimeter of the prohibited closure zone. Using newly available analytical methods and hydrographic equipment, the FDA is undertaking studies to determine whether its 1,000:1 dilution recommendation is supported by the findings. From 2007 through 2009, the FDA conducted field investigations to assess the impacts of wastewater effluent from a large municipal WWTP that discharges into Alabama's Mobile Bay. The dilution of the effluent in the bay was ascertained by conducting a hydrographic dye study using rhodamine WT tracer dye. Submersible fluorometers fastened to oyster cages at sentinel stations were used to determine continuously the dilution of the dye-tagged effluent throughout a 4-day study period. In addition, dilution and dispersion of the dye-tagged effluent was tracked throughout Mobile Bay by fluorometric measurements made while conducting boat transects. The microbiological impacts of the wastewater on molluscan shellfish were assessed by testing oysters placed in cages at sentinel stations at various distances along the anticipated path of the effluent. Levels of fecal coliforms, Escherichia coli, male-specific coliphage, and norovirus genogroups I and II were determined. Norovirus genogroup II was detected in oysters that were located as far as 5.74 km from the discharge, an area in close proximity to the calculated 1,000:1 dilution line. Results also showed that the levels of indicator microorganisms and viral pathogens in the shellfish inversely correlated with increased dilutions of the wastewater effluent in Mobile Bay. JF - Journal of Shellfish Research AU - Goblick, Gregory N AU - Anbarchian, Julie Mayer AU - Woods, Jacquelina AU - Burkhardt, William AU - Calci, Kevin AD - Office of Food Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, HFS-325, College Park, MD 20740, gregory.goblick@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 979 EP - 987 PB - National Shellfisheries Association VL - 30 IS - 3 SN - 0730-8000, 0730-8000 KW - Environment Abstracts; Virology & AIDS Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts KW - wastewater KW - shellfish KW - growing area KW - treatment plant KW - Submersibles KW - ASW, USA, Alabama, Mobile Bay KW - Wastewater treatment KW - Public health KW - Sewage disposal KW - Tracers KW - Boats KW - Escherichia coli KW - Mollusca KW - Marine KW - Fecal coliforms KW - Shellfish culture KW - Norovirus KW - Pathogens KW - Food plants KW - Effluents KW - Cages KW - Oysters KW - FDA KW - Wastewater discharges KW - Microorganisms KW - Marine molluscs KW - Shellfish KW - Waste water KW - rhodamine KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - V 22410:Animal Diseases KW - ENA 12:Oceans & Estuaries KW - Q3 08588:Effects of Aquaculture on the Environment KW - Q1 08588:Effects of Aquaculture on the Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954659543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Shellfish+Research&rft.atitle=Evaluating+the+Dilution+of+Wastewater+Treatment+Plant+Effluent+and+Viral+Impacts+on+Shellfish+Growing+Areas+in+Mobile+Bay%2C+Alabama&rft.au=Goblick%2C+Gregory+N%3BAnbarchian%2C+Julie+Mayer%3BWoods%2C+Jacquelina%3BBurkhardt%2C+William%3BCalci%2C+Kevin&rft.aulast=Goblick&rft.aufirst=Gregory&rft.date=2011-12-01&rft.volume=30&rft.issue=3&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Journal+of+Shellfish+Research&rft.issn=07308000&rft_id=info:doi/10.2983%2F035.030.0341 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Number of references - 29 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Sewage disposal; Shellfish culture; Submersibles; Marine molluscs; Pathogens; Effluents; Wastewater treatment; Cages; Public health; Tracers; Fecal coliforms; Boats; Microorganisms; Food plants; Waste water; rhodamine; Oysters; Wastewater discharges; FDA; Shellfish; Escherichia coli; Norovirus; Mollusca; ASW, USA, Alabama, Mobile Bay; Marine DO - http://dx.doi.org/10.2983/035.030.0341 ER - TY - JOUR T1 - Socioeconomic deprivation impact on meat intake and mortality: NIH-AARP Diet and Health Study AN - 926896815; 16333538 AB - Objective: Previous studies have not examined potential interactions between meat intake and characteristics of the local environment on the risk of mortality. This study examined the impact of area socioeconomic deprivation on the association between meat intake and all-cause and cause-specific mortality after accounting for individual-level risk factors. Methods: In the prospective NIH-AARP Diet and Health Study, we analyzed data from adults, ages 50-71 years at baseline (1995-1996). Individual-level dietary intake and health risk information were linked to the demographic and socioeconomic context of participants' local environment based on census tract data. Deaths (n = 33,831) were identified through December 2005. Multilevel Cox models were used to estimate hazard ratios and 95% confidence intervals for quintiles of area deprivation scores. Results: Associations of red and processed meats with mortality were consistent across deprivation quintiles. Men residing in least-deprived neighborhoods had a stronger protective effect for white meat consumption. No differences by deprivation index were observed for women. Conclusion: Red and processed meat intake increases mortality risk regardless of level of deprivation within a given neighborhood suggesting biological mechanisms rather than neighborhood contextual factors may underlie these meat-mortality associations. The effect of white meat intake on cancer mortality was modified by area deprivation among men. JF - Cancer Causes & Control AU - Major, Jacqueline M AU - Cross, Amanda J AU - Doubeni, Chyke A AU - Park, Yikyung AU - Lian, Min AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Graubard, Barry I AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD, 20852, USA, Jacqueline.major@nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1699 EP - 1707 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Census KW - Demography KW - Diets KW - Meat KW - Mortality KW - Risk assessment KW - Risk factors KW - Socioeconomics KW - census KW - demography KW - meat KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926896815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Socioeconomic+deprivation+impact+on+meat+intake+and+mortality%3A+NIH-AARP+Diet+and+Health+Study&rft.au=Major%2C+Jacqueline+M%3BCross%2C+Amanda+J%3BDoubeni%2C+Chyke+A%3BPark%2C+Yikyung%3BLian%2C+Min%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BGraubard%2C+Barry+I%3BSinha%2C+Rashmi&rft.aulast=Major&rft.aufirst=Jacqueline&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1699&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9846-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Demography; Meat; demography; Risk assessment; census; Diets; Mortality; Risk factors; meat; Socioeconomics; Census; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9846-0 ER - TY - JOUR T1 - Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability AN - 926892337; 16401653 AB - This report examined blood-brain barrier (BBB) related proinflammatory mediators and permeability changes in response to various sized gold nanoparticles (Au-NPs) (3, 5, 7, 10, 30 and 60 nm) in vitro using primary rat brain microvessel endothelial cells (rBMEC). The Au-NPs were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and laser Doppler velocimetry (LDV). The accumulation of Au-NPs was determined spectrophotometrically. The rBMEC cytotoxicity of Au-NPs was evaluated by cell proliferation assay (XTT) (concentration range 0.24-15.63 mu g/cm super(2), for 24 h). The time-dependent changes (0, 2, 4 and 8 h) of several proinflammatory mediators (IL-1 beta , IL-2, TNF alpha and PGE sub(2)) were evaluated by ELISA. The smaller Au-NPs (3-7 nm) showed higher rBMEC accumulation compared to larger Au-NPs (10-60 nm), while only moderate decreased cell viability was observed with small Au-NPs (3 nm) at high concentrations ( greater than or equal to 7.8 mu g/cm super(2)). Even though slight changes in cell viability were observed with small Au-NPs, the basal levels of the various proinflammatory mediators remained unchanged with all treatments except LPS (positive control). rBMEC morphology appeared unaffected 24 h after exposure to Au-NPs with only mild changes in fluorescein permeability indicating BBB integrity was unaltered. Together, these data suggest the responses of the cerebral microvasculature to Au-NPs have a significant relationship with the Au-NPs unique size-dependent physiochemical properties. JF - Nanotoxicology AU - Trickler, W J AU - Lantz, S M AU - Murdock, R C AU - Schrand, A M AU - Robinson, B L AU - Newport, G D AU - Schlager, J J AU - Oldenburg, S J AU - Paule, M G AU - Slikker, W Jr AU - Hussain, S M AU - Ali, S F AD - Neurochemistry Laboratory, Division of Neurotoxicology, HFT-132, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA, syed.ali@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 479 EP - 492 VL - 5 IS - 4 SN - 1743-5390, 1743-5390 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Blood-brain barrier KW - Inflammation KW - X:24390 KW - N3:11007 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Brain+microvessel+endothelial+cells+responses+to+gold+nanoparticles%3A+In+vitro+pro-inflammatory+mediators+and+permeability&rft.au=Trickler%2C+W+J%3BLantz%2C+S+M%3BMurdock%2C+R+C%3BSchrand%2C+A+M%3BRobinson%2C+B+L%3BNewport%2C+G+D%3BSchlager%2C+J+J%3BOldenburg%2C+S+J%3BPaule%2C+M+G%3BSlikker%2C+W+Jr%3BHussain%2C+S+M%3BAli%2C+S+F&rft.aulast=Trickler&rft.aufirst=W&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.540356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Inflammation DO - http://dx.doi.org/10.3109/17435390.2010.540356 ER - TY - JOUR T1 - Gold nanoparticle trafficking of typically excluded compounds across the cell membrane in JB6 CI 41-5a cells causes assay interference AN - 926892332; 16401652 AB - Nanoparticles (NP) often interfere with the mechanism and interpretation of high throughput in vitro toxicity assays. This interference may occur at any time during the assay and spans most NP systems. This study reports on a specific type of gold NP assay interference, where unmodified gold NPs were able to traffic certain assay molecules that contained primary amines across the cell membrane resulting in false positive results for toxicity assays. The enhanced assay molecule permeability was eliminated when the gold NP surface was both sterically and chemically blocked by polyethylene glycol (PEG). The results support the growing consensus that appropriate controls and assay validation should occur prior to interpretation of results of assays using NP. JF - Nanotoxicology AU - Keene, A M AU - Allaway, R J AU - Sadrieh, N AU - Tyner, K M AD - Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, katherine.tyner@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 469 EP - 478 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN United Kingdom VL - 5 IS - 4 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Permeability KW - amines KW - Cell membranes KW - Gold KW - Toxicity KW - Polyethylene glycol KW - nanoparticles KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Gold+nanoparticle+trafficking+of+typically+excluded+compounds+across+the+cell+membrane+in+JB6+CI+41-5a+cells+causes+assay+interference&rft.au=Keene%2C+A+M%3BAllaway%2C+R+J%3BSadrieh%2C+N%3BTyner%2C+K+M&rft.aulast=Keene&rft.aufirst=A&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.533792 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Permeability; amines; Cell membranes; Gold; Toxicity; nanoparticles; Polyethylene glycol DO - http://dx.doi.org/10.3109/17435390.2010.533792 ER - TY - JOUR T1 - Patterns of meat intake and risk of prostate cancer among African-Americans in a large prospective study AN - 926892048; 16333537 AB - Objective: Given the large racial differences in prostate cancer risk, further investigation of diet and prostate cancer is warranted among high-risk groups. The purpose of this study was to examine the association between type of meat intake and prostate cancer risk among African-American men. Methods: In the large, prospective NIH-AARP Diet and Health Study, we analyzed baseline (1995-1996) data from African-American participants, aged 50-71 years. Incident prostate cancer cases (n = 1,089) were identified through 2006. Dietary and risk factor data were ascertained by questionnaires administered at baseline. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) within intake quantiles. Results: Neither white nor processed meat intake was associated with prostate cancer, regardless of meat-cooking method. Red meats cooked at high temperatures were associated with an increased risk of prostate cancer (HR = 1.18, 95% CI = 1.00-1.38 and HR = 1.22, 95% CI = 1.03-1.44, for the upper two intake tertiles). Intake of the heterocyclic amine (HCA), 2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline (DiMeIQx) was positively associated with prostate cancer (HR = 1.30; 95% CI = 1.05-1.61, p = 0.02). No associations were observed for intake of other HCAs. Conclusion: Red meats cooked at high temperatures were positively associated with prostate cancer risk among African-American men. Further studies are needed to replicate these findings. JF - Cancer Causes & Control AU - Major, Jacqueline M AU - Cross, Amanda J AU - Watters, Joanne L AU - Hollenbeck, Albert R AU - Graubard, Barry I AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD, 20852, USA, jacqueline.major@nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1691 EP - 1698 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Diets KW - Meat KW - Risk factors KW - High temperature KW - meat KW - prostate cancer KW - Amines KW - Ethnic groups KW - Cancer KW - high temperature KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Patterns+of+meat+intake+and+risk+of+prostate+cancer+among+African-Americans+in+a+large+prospective+study&rft.au=Major%2C+Jacqueline+M%3BCross%2C+Amanda+J%3BWatters%2C+Joanne+L%3BHollenbeck%2C+Albert+R%3BGraubard%2C+Barry+I%3BSinha%2C+Rashmi&rft.aulast=Major&rft.aufirst=Jacqueline&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1691&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9845-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Meat; Diets; High temperature; Risk factors; meat; Amines; prostate cancer; high temperature; Cancer; Ethnic groups DO - http://dx.doi.org/10.1007/s10552-011-9845-1 ER - TY - JOUR T1 - Impact of hysterectomy and bilateral oophorectomy prevalence on rates of cervical, uterine, and ovarian cancer among American Indian and Alaska Native women, 1999-2004 AN - 926892044; 16333536 AB - Objective: To present more accurate incidence rates of cervical, uterine, and ovarian cancer by geographic region in American Indian/Alaska Native (AI/AN) women. Methods: The authors used data from central cancer registries linked to Indian Health Service (IHS) patient registration database, the Behavioral Risk Factor Surveillance System, IHS National Data Warehouse, and the National Hospital Discharge Survey. Cancer incidence rates were adjusted for hysterectomy and oophorectomy prevalence and presented by region for non-Hispanic White (NHW) and AI/AN women. Results: AI/AN women had a higher prevalence of hysterectomy (23.1%) compared with NHW women (20.9%). Correcting cancer rates for population-at-risk significantly increased the cancer incidence rates among AI/AN women: 43% for cervical cancer, 67% for uterine cancer, and 37% for ovarian cancer. Risk-correction led to increased differences in cervical cancer incidence between AI/AN and NHW women in certain regions. Conclusions: Current reporting of cervical, uterine, and ovarian cancer underestimates the incidence in women at risk and can affect the measure of cancer disparities. Improved cancer surveillance using methodology to correct for population-at-risk may better inform disease control priorities for AI/AN populations. JF - Cancer Causes & Control AU - Wong, Charlene A AU - Jim, Melissa A AU - King, Jessica AU - Tom-Orme, Lillian AU - Henderson, Jeffrey A AU - Saraiya, Mona AU - Richardson, Lisa C AU - Layne, Larry AU - Suryaprasad, Anil AU - Espey, David K AD - Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers of Disease Control and Prevention, Atlanta, GA, USA, david.espey@ihs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1681 EP - 1689 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 12 SN - 0957-5243, 0957-5243 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Cancer KW - Disease control KW - Ethnic groups KW - Females KW - Hospitals KW - Ovarian carcinoma KW - Risk factors KW - disease control KW - ovarian carcinoma KW - INE, USA, Alaska KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926892044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Impact+of+hysterectomy+and+bilateral+oophorectomy+prevalence+on+rates+of+cervical%2C+uterine%2C+and+ovarian+cancer+among+American+Indian+and+Alaska+Native+women%2C+1999-2004&rft.au=Wong%2C+Charlene+A%3BJim%2C+Melissa+A%3BKing%2C+Jessica%3BTom-Orme%2C+Lillian%3BHenderson%2C+Jeffrey+A%3BSaraiya%2C+Mona%3BRichardson%2C+Lisa+C%3BLayne%2C+Larry%3BSuryaprasad%2C+Anil%3BEspey%2C+David+K&rft.aulast=Wong&rft.aufirst=Charlene&rft.date=2011-12-01&rft.volume=22&rft.issue=12&rft.spage=1681&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9844-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Risk factors; ovarian carcinoma; Disease control; Ovarian carcinoma; Females; disease control; Ethnic groups; Cancer; Hospitals; INE, USA, Alaska DO - http://dx.doi.org/10.1007/s10552-011-9844-2 ER - TY - BOOK T1 - Injuries, Illnesses & Fatalities in Wholesale and Retail Trade in 2005: A Chartbook AN - 925721488; 2011-205640 AB - This Chartbook provides a summary of fatal and nonfatal injury/illness information describing a large population of understudied workplaces and workers: the wholesale and retail trade (WRT) sector. The WRT sector consists of one of ten industry sectors formed from stakeholder meetings conducted throughout the U.S. by NIOSH that served to define the structure of the second decade of NORA. The contents of the WRT Chartbook are based on data from the mid-decade year of 2005. This year was chosen to serve as the baseline for the WRT sector, which corresponds to the launch of the second decade of NORA. The purpose of this Chartbook is to identify high-risk subsectors, as well as industries, occupations, and tasks, in the WRT sector for 2005. Researchers and practitioners will be able to use the Chartbook as a resource to address the controls and prevention needed for reducing the workplace injuries/illnesses and fatalities occurring in the WRT sector. The primary information source for the WRT Chartbook is the U.S. Bureau of Labor Statistics (BLS), which incorporates additional data from the Current Population Survey (CPS) provided by the U.S. Census Bureau, among other related sources [BLS 2010]. The BLS provides through its Web site an extensive set of files containing information on the number and rates of occupational injuries, illnesses, and fatalities. The WRT Chartbook can serve to alert employers, employees, and researchers to hazards in the WRT sector that may affect them, and provide direction for new research and prevention efforts in the sector. The data are presented as tables and charts. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Dec 2011, 146 pp. AU - National Inst Occupational Safety and Health Y1 - 2011/12// PY - 2011 DA - December 2011 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Social conditions and policy - Public safety and security KW - Science and technology policy - Biology and biotechnology KW - Business and service sector - Retail business KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Business and service sector - Business operations, practices, and workplaces KW - Retail trade KW - Death KW - Personal injuries KW - Workplaces KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925721488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2011-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Injuries%2C+Illnesses+%26+Fatalities+in+Wholesale+and+Retail+Trade+in+2005%3A+A+Chartbook&rft.title=Injuries%2C+Illnesses+%26+Fatalities+in+Wholesale+and+Retail+Trade+in+2005%3A+A+Chartbook&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2012-106/pdfs/2012-106.pdf LA - English DB - PAIS Index N1 - Date revised - 2012-03-01 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2011 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Estimation of variant Creutzfeldt-Jakob disease infectivity titers in human blood AN - 920790061; 16162309 AB - BACKGROUND: Blood of individuals with variant Creutzfeldt-Jakob disease (vCJD) is infectious but the titer is unknown. Current estimates of possible vCJD infectivity titers in blood have largely relied on an assumption that the titers of vCJD agent in human blood are likely to be similar to those in blood of rodents infected with model transmissible spongiform encephalopathy agents, assayed by intracerebral inoculations of rodents of the same species. STUDY DESIGN AND METHODS: We analyzed published descriptions of experimental transfusion-transmitted (TT) bovine spongiform encephalopathy and scrapie in sheep and reports of TTvCJD in humans, applying statistical approaches to estimate the probable number of intravenous infectious doses (IDiv) per unit of transfused blood (IDiv/unit). For humans, IDiv/unit of nonleukoreduced red blood cells (NLR-RBCs) were estimated by two statistical models. RESULTS: Sheep blood collected at or near onset of clinical illness contained a mean of 0.80IDiv/unit. Estimates of infectivity in NLR-RBCs from donors incubating vCJD indicated a probable mean infectivity of 0.29IDiv/unit (Model1) and 0.75IDiv/unit (Model2). The analysis predicted a mean of 21 vCJD-infected recipients expected in a cohort transfused with vCJD-implicated NLR-RBCs in the United Kingdom. CONCLUSION: Our analysis suggested that, while less than one IDiv is likely to be present in a given unit of NLR-RBCs collected from a donor incubating vCJD, there is a high probability of TT infection among recipients of vCJD-implicated blood components. The analysis supports continuing measures currently recommended to reduce the risk of TTvCJD. JF - Transfusion AU - Gregori, Luisa AU - Yang, Hong AU - Anderson, Steven AD - From the Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Rockville, Maryland; and the Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 2596 EP - 2602 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 51 IS - 12 SN - 0041-1132, 0041-1132 KW - CSA Neurosciences Abstracts; Virology & AIDS Abstracts; Risk Abstracts KW - Bovine spongiform encephalopathy KW - Creutzfeldt-Jakob disease KW - sheep KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920790061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Estimation+of+variant+Creutzfeldt-Jakob+disease+infectivity+titers+in+human+blood&rft.au=Gregori%2C+Luisa%3BYang%2C+Hong%3BAnderson%2C+Steven&rft.aulast=Gregori&rft.aufirst=Luisa&rft.date=2011-12-01&rft.volume=51&rft.issue=12&rft.spage=2596&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2011.03199.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-02-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - Creutzfeldt-Jakob disease; sheep DO - http://dx.doi.org/10.1111/j.1537-2995.2011.03199.x ER - TY - JOUR T1 - Cell Sources for Bone Regeneration: The Good, the Bad, and the Ugly (But Promising) AN - 915493426; 16153214 AB - Based on the extensive investigation of various ways to regenerate bone, bone marrow stromal cells, in conjunction with ceramic scaffolds, show great promise for application in human patients, and are already in use in a limited number of clinical trials. In preparing for clinical trials, scale-up current good manufacturing processes (cGMP) must incorporate the use of appropriate assays to ensure that the resulting cell product has maintained its biological activity. Future developments are needed to identify better scaffolds, and better ways to deliver cells with either injectable carriers, or by developing techniques to aide in their escape from the circulation and their incorporation into the pre-existing tissue. Lastly, development of methods that faithfully direct pluripotent stem cell differentiation into populations of osteogenic precursors (and ideally, containing skeletal stem cells) represents a new challenge in the field of bone regeneration, but also offer new opportunities to not only to study the biology of bone formation, but also to develop a robust cell source for bone regeneration. JF - Tissue Engineering, Part B: Reviews AU - Robey, P G AD - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, 30 Convent Drive MSC 4320, Building 30, Room 228, Bethesda, MD 20892, USA, probey@dir.nidcr.nih.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 423 EP - 430 VL - 17 IS - 6 SN - 1937-3368, 1937-3368 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - stromal cells KW - Bone marrow KW - Bone growth KW - Tissue engineering KW - Clinical trials KW - scaffolds KW - Ceramics KW - Cyclic GMP KW - Differentiation KW - Stem cells KW - Reviews KW - Regeneration KW - Osteoprogenitor cells KW - Osteogenesis KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915493426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.atitle=Cell+Sources+for+Bone+Regeneration%3A+The+Good%2C+the+Bad%2C+and+the+Ugly+%28But+Promising%29&rft.au=Robey%2C+P+G&rft.aulast=Robey&rft.aufirst=P&rft.date=2011-12-01&rft.volume=17&rft.issue=6&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.issn=19373368&rft_id=info:doi/10.1089%2Ften.teb.2011.0199 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - stromal cells; Bone growth; Bone marrow; Tissue engineering; Clinical trials; scaffolds; Cyclic GMP; Ceramics; Differentiation; Stem cells; Reviews; Regeneration; Osteoprogenitor cells; Osteogenesis DO - http://dx.doi.org/10.1089/ten.teb.2011.0199 ER - TY - JOUR T1 - Group Medical Claims as a Source of Information on Worker Health and Potentially Work-Related Diseases AN - 915490387; 16152701 AB - Objective: To help address underrecognition of occupational illnesses and support planning of workplace health initiatives. Methods: Data from High-mark Inc., a health care insurer headquartered in Pittsburgh and Camp Hill, Pennsylvania, was used to calculate age and gender-adjusted rates of 15 diseases by industry and broad industry sector. Results: Significant industry differences in disease rates were observed, some corresponding to known differences in workplace risk factors. Conclusion: Group medical claims offer timely, relatively low cost, longitudinal data on rates of physician-diagnosed cases and costs of many diseases for large populations. Limitations of medical claims data include inaccuracies in industry coding, lack of occupation codes, and lack of key variables that affect health. Yet, some elevated industry rates suggest potential new targets for weltaess programs and evaluation of possible workplace health risks. JF - Journal of Occupational and Environmental Medicine AU - Bushnell, P T AU - Li, J AU - Landen, D AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R17, Cincinnati, OH 45226, USA, PLB4@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1430 EP - 1441 VL - 53 IS - 12 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Health care KW - Risk assessment KW - Risk factors KW - hills KW - USA, Pennsylvania KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/915490387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Group+Medical+Claims+as+a+Source+of+Information+on+Worker+Health+and+Potentially+Work-Related+Diseases&rft.au=Bushnell%2C+P+T%3BLi%2C+J%3BLanden%2C+D&rft.aulast=Bushnell&rft.aufirst=P&rft.date=2011-12-01&rft.volume=53&rft.issue=12&rft.spage=1430&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3182363bbe LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Risk assessment; hills; Age; Health care; Risk factors; USA, Pennsylvania DO - http://dx.doi.org/10.1097/JOM.0b013e3182363bbe ER - TY - JOUR T1 - The Effect Of Diabetes On Female Labor Force Decisions: New Evidence From The National Health Interview Survey AN - 914790752; 201200600 AB - This paper estimates the effect of diabetes on labor-force participation, hours worked, days-out-of-work due to illness, and earnings using data from the National Health Interview Survey. Findings indicate that diabetes, estimated wholly, is significantly detrimental to most labor market outcomes. However, separation of type I and II diabetes shows that much of the negative effect is due to type II diabetes. On average a female with type II diabetes can experience a wage penalty of almost 50% relative to a healthy individual. Additionally, estimates of specifically type II diabetes may be subject to endogeneity bias. To account for this, I utilize whether an individual's biological mother has been diagnosed with diabetes as an instrumental variable. This instrument provides both theoretical and statistical explanatory power to separate the causal effect of type II diabetes on labor-force decisions. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Minor, Travis AD - FDA/CFSAN, CPK1 HFS-020, 5100 Paint Branch Parkway, College Park, MD 20910, USA Travis.Minor@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 1468 EP - 1486 PB - John Wiley, Chichester UK VL - 20 IS - 12 SN - 1057-9230, 1057-9230 KW - diabetes, labor supply, wages, instrumental variables KW - Type 2 diabetes mellitus KW - Labour market KW - Wages KW - Health KW - Earnings KW - Diabetes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/914790752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=The+Effect+Of+Diabetes+On+Female+Labor+Force+Decisions%3A+New+Evidence+From+The+National+Health+Interview+Survey&rft.au=Minor%2C+Travis&rft.aulast=Minor&rft.aufirst=Travis&rft.date=2011-12-01&rft.volume=20&rft.issue=12&rft.spage=1468&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1685 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-01-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Diabetes; Type 2 diabetes mellitus; Health; Earnings; Wages; Labour market DO - http://dx.doi.org/10.1002/hec.1685 ER - TY - JOUR T1 - A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat AN - 911158909; 16094903 AB - Cardiotoxicity was an unanticipated side effect elicited by the clinical use of imatinib (Imb). This toxicity has been examined in only a limited number of experimental studies. The present study sought, by a variety of approaches, to identify important characteristics of Imb-induced cardiac alterations. Male spontaneously hypertensive rats (SHRs) received oral doses of 10, 30, or 50 mg/kg Imb or water daily for 10 d. Cardiac lesions, detected at all doses, were characterized by cytoplasmic vacuolization and myofibrillar loss. In a second experiment, cardiac lesions were found in Sprague Dawley (SD) and SHR rats given 50 or 100 mg/kg Imb for 14 d. Mean cardiac lesion scores and serum levels of cardiac troponin I were higher in SHRs than in SD rats. Imb induced myocyte death by necrosis, autophagy, and apoptosis. Dose-related increases in cardiac expression were observed for several genes associated with endoplasmic reticulum stress response, protein folding, and vascular development and remodeling. Imb caused alterations in isolated myocytes (myofibrillar loss, highly disrupted and disorganized sarcomeric alpha -actinin, apoptosis, and increased lactate dehydrogenase release) at low concentrations (5 mM). The authors conclude that Imb exerts cardiotoxic effects that are manifest through a complex pattern of cellular alterations, the severity of which can be influenced by arterial blood pressure. JF - Toxicologic Pathology AU - Herman, Eugene H AU - Knapton, Alan AU - Rosen, Elliot AU - Thompson, Karol AU - Rosenzweig, Barry AU - Estis, Joel AU - Agee, Sara AU - Lu, Quynh-Anh AU - Todd, John A AU - Lipshultz, Steven AU - Hasinoff, Brian AU - Zhang, Jun AD - Food and Drug Administration, Division of Applied Pharmacology Research, Silver Spring, Maryland, USA  , eugene.herman@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1091 EP - 1106 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 39 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Heart KW - Myocytes KW - Apoptosis KW - Actinin KW - Stress KW - Toxicity KW - Blood pressure KW - L-Lactate dehydrogenase KW - Imatinib KW - Serum levels KW - Endoplasmic reticulum KW - Necrosis KW - Protein folding KW - Troponin I KW - Phagocytosis KW - Side effects KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911158909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=A+Multifaceted+Evaluation+of+Imatinib-induced+Cardiotoxicity+in+the+Rat&rft.au=Herman%2C+Eugene+H%3BKnapton%2C+Alan%3BRosen%2C+Elliot%3BThompson%2C+Karol%3BRosenzweig%2C+Barry%3BEstis%2C+Joel%3BAgee%2C+Sara%3BLu%2C+Quynh-Anh%3BTodd%2C+John+A%3BLipshultz%2C+Steven%3BHasinoff%2C+Brian%3BZhang%2C+Jun&rft.aulast=Herman&rft.aufirst=Eugene&rft.date=2011-12-01&rft.volume=39&rft.issue=7&rft.spage=1091&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623311419524 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Heart; Myocytes; Apoptosis; Actinin; Stress; Toxicity; Blood pressure; L-Lactate dehydrogenase; Serum levels; Imatinib; Endoplasmic reticulum; Necrosis; Protein folding; Phagocytosis; Troponin I; Side effects DO - http://dx.doi.org/10.1177/0192623311419524 ER - TY - JOUR T1 - Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling. AN - 907035160; 22087542 AB - A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. The differential gene expression profile induced by silica correlated with its toxicity in the A549 cells. The biological processes perturbed by silica exposure in the A549 cells and rat lungs, as identified by the bioinformatics analysis of the differentially expressed genes, demonstrated significant similarity. Functional categorization of the differentially expressed genes identified cancer, cellular movement, cellular growth and proliferation, cell death, inflammatory response, cell cycle, cellular development, and genetic disorder as top ranking biological functions perturbed by silica exposure in A549 cells and rat lungs. Results of our study, in addition to confirming several previously identified molecular targets and mechanisms involved in silica toxicity, identified novel molecular targets and mechanisms potentially involved in silica-induced pulmonary toxicity. Further investigations, including those focused on the novel molecular targets and mechanisms identified in the current study may result in better management and, possibly, reduction and/or prevention of the potential adverse health effects associated with crystalline silica exposure. JF - Inhalation toxicology AU - Sellamuthu, Rajendran AU - Umbright, Christina AU - Li, Shengqiao AU - Kashon, Michael AU - Joseph, Pius AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV 26505, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 927 EP - 937 VL - 23 IS - 14 KW - Quartz KW - 14808-60-7 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Inbred F344 KW - Cell Survival -- drug effects KW - Humans KW - Microarray Analysis KW - Cell Line, Tumor KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Lung -- drug effects KW - Gene Expression Regulation -- drug effects KW - Lung -- metabolism KW - Quartz -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907035160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Mechanisms+of+crystalline+silica-induced+pulmonary+toxicity+revealed+by+global+gene+expression+profiling.&rft.au=Sellamuthu%2C+Rajendran%3BUmbright%2C+Christina%3BLi%2C+Shengqiao%3BKashon%2C+Michael%3BJoseph%2C+Pius&rft.aulast=Sellamuthu&rft.aufirst=Rajendran&rft.date=2011-12-01&rft.volume=23&rft.issue=14&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2011.625995 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-13 N1 - Date created - 2011-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/08958378.2011.625995 ER - TY - JOUR T1 - Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. AN - 905676027; 21908763 AB - Kava is a plant traditionally used for making beverages in Pacific Basin countries and has been used for the treatment of nervous disorders in the United States. The pharmacological activity of kava is achieved through kavalactones in kava extract, which include kawain, 7,8-dihydrokawain, yangonin, 5,6-dehydrokawain, methysticin, and 7,8-dihydromethysticin. Recent studies have shown that kava extract induces hepatic CYP1A1 enzyme; however, the mechanisms of CYP1A1 induction have not been elucidated, and the kavalactones responsible for CYP1A1 induction have not yet been identified. Using a combination of biochemical assays and molecular docking tools, we determined the functions of kava extract and kavalactones and delineated the underlying mechanisms involved in CYP1A1 induction. The results showed that kava extract displayed a concentration-dependent effect on CYP1A1 induction. Among the six major kavalactones, methysticin triggered the most profound inducing effect on CYP1A1 followed by 7,8-dihydromethysticin. The other four kavalactones (yangonin, 5,6-dehydrokawain, kawain, and 7,8-dihydrokawain) did not show significant effects on CYP1A1. Consistent with the experimental results, in silico molecular docking studies based on the aryl hydrocarbon receptor (AhR)-ligand binding domain homology model also revealed favorable binding to AhR for methysticin and 7,8-dihydromethysticin compared with the remaining kavalactones. Additionally, results from a luciferase gene reporter assay suggested that kava extract, methysticin, and 7,8-dihydromethysticin were able to activate the AhR signaling pathway. Moreover, kava extract-, methysticin-, and 7,8-dihydromethysticin-mediated CYP1A1 induction was blocked by an AhR antagonist and abolished in AhR-deficient cells. These findings suggest that kava extract induces the expression of CYP1A1 via an AhR-dependent mechanism and that methysticin and 7,8-dihydromethysticin contribute to CYP1A1 induction. The induction of CYP1A1 indicates a potential interaction between kava or kavalactones and CYP1A1-mediated chemical carcinogenesis. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Li, Yan AU - Mei, Hu AU - Wu, Qiangen AU - Zhang, Suhui AU - Fang, Jia-Long AU - Shi, Leming AU - Guo, Lei AD - Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 388 EP - 399 VL - 124 IS - 2 KW - 7,8-dihydromethysticin KW - 0 KW - Lactones KW - Ligands KW - Plant Extracts KW - Pyrans KW - Pyrones KW - Receptors, Aryl Hydrocarbon KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - methysticin KW - M832AIJ6HX KW - Index Medicus KW - Gene Expression -- drug effects KW - Molecular Structure KW - Animals KW - Dose-Response Relationship, Drug KW - Models, Molecular KW - Cell Line, Tumor KW - Mice KW - Protein Binding KW - Binding Sites KW - Cell Survival -- drug effects KW - Transfection KW - Receptors, Aryl Hydrocarbon -- agonists KW - Enzyme Induction KW - Receptors, Aryl Hydrocarbon -- genetics KW - Pyrones -- pharmacology KW - Pyrans -- pharmacology KW - Lactones -- isolation & purification KW - Cytochrome P-450 CYP1A1 -- genetics KW - Pyrans -- isolation & purification KW - Pyrones -- isolation & purification KW - Kava -- chemistry KW - Plant Extracts -- chemistry KW - Cytochrome P-450 CYP1A1 -- biosynthesis KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905676027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Methysticin+and+7%2C8-dihydromethysticin+are+two+major+kavalactones+in+kava+extract+to+induce+CYP1A1.&rft.au=Li%2C+Yan%3BMei%2C+Hu%3BWu%2C+Qiangen%3BZhang%2C+Suhui%3BFang%2C+Jia-Long%3BShi%2C+Leming%3BGuo%2C+Lei&rft.aulast=Li&rft.aufirst=Yan&rft.date=2011-12-01&rft.volume=124&rft.issue=2&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr235 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-16 N1 - Date created - 2011-11-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr235 ER - TY - JOUR T1 - Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States. AN - 904014674; 21947397 AB - Resistance to extended-spectrum cephalosporins (ESC) among members of the family Enterobacteriaceae occurs worldwide; however, little is known about ESC resistance in Escherichia coli strains from companion animals. Clinical isolates of E. coli were collected from veterinary diagnostic laboratories throughout the United States from 2008 to 2009. E. coli isolates (n = 54) with reduced susceptibility to ceftazidime or cefotaxime (MIC ≥ 16 μg/ml) and extended-spectrum-β-lactamase (ESBL) phenotypes were analyzed. PCR and sequencing were used to detect mutations in ESBL-encoding genes and the regulatory region of the chromosomal gene ampC. Conjugation experiments and plasmid identification were conducted to examine the transferability of resistance to ESCs. All isolates carried the bla(CTX-M-1)-group β-lactamase genes in addition to one or more of the following β-lactamase genes: bla(TEM), bla(SHV-3), bla(CMY-2), bla(CTX-M-14-like), and bla(OXA-1.) Different bla(TEM) sequence variants were detected in some isolates (n = 40). Three isolates harbored a bla(TEM-181) gene with a novel mutation resulting in an Ala184Val substitution. Approximately 78% of the isolates had mutations in promoter/attenuator regions of the chromosomal gene ampC, one of which was a novel insertion of adenine between bases -28 and -29. Plasmids ranging in size from 11 to 233 kbp were detected in the isolates, with a common plasmid size of 93 kbp identified in 60% of isolates. Plasmid-mediated transfer of β-lactamase genes increased the MICs (≥ 16-fold) of ESCs for transconjugants. Replicon typing among isolates revealed the predominance of IncI and IncFIA plasmids, followed by IncFIB plasmids. This study shows the emergence of conjugative plasmid-borne ESBLs among E. coli strains from companion animals in the United States, which may compromise the effective therapeutic use of ESCs in veterinary medicine. JF - Antimicrobial agents and chemotherapy AU - Shaheen, Bashar W AU - Nayak, Rajesh AU - Foley, Steven L AU - Kweon, Ohgew AU - Deck, Joanna AU - Park, Miseon AU - Rafii, Fatemeh AU - Boothe, Dawn M AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA. bashar.shaheen@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 5666 EP - 5675 VL - 55 IS - 12 KW - Anti-Bacterial Agents KW - 0 KW - Cephalosporins KW - Escherichia coli Proteins KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Plasmids -- genetics KW - Conjugation, Genetic KW - Cat Diseases -- microbiology KW - beta-Lactamases -- genetics KW - beta-Lactamases -- chemistry KW - Cats KW - Dog Diseases -- microbiology KW - Dogs KW - Electrophoresis, Gel, Pulsed-Field KW - United States -- epidemiology KW - Microbial Sensitivity Tests KW - beta-Lactamases -- metabolism KW - Escherichia coli Proteins -- genetics KW - Pets KW - Escherichia coli Infections -- microbiology KW - Cephalosporins -- pharmacology KW - Cephalosporin Resistance -- genetics KW - Escherichia coli Infections -- veterinary KW - Escherichia coli -- isolation & purification KW - Escherichia coli Infections -- epidemiology KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904014674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Molecular+characterization+of+resistance+to+extended-spectrum+cephalosporins+in+clinical+Escherichia+coli+isolates+from+companion+animals+in+the+United+States.&rft.au=Shaheen%2C+Bashar+W%3BNayak%2C+Rajesh%3BFoley%2C+Steven+L%3BKweon%2C+Ohgew%3BDeck%2C+Joanna%3BPark%2C+Miseon%3BRafii%2C+Fatemeh%3BBoothe%2C+Dawn+M&rft.aulast=Shaheen&rft.aufirst=Bashar&rft.date=2011-12-01&rft.volume=55&rft.issue=12&rft.spage=5666&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00656-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-29 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 2000 Sep;44(9):2534-6 [10952609] Vet Microbiol. 2010 Aug 26;144(3-4):363-70 [20233641] Antimicrob Agents Chemother. 2001 Oct;45(10):2716-22 [11557460] Clin Microbiol Rev. 2001 Oct;14(4):933-51, table of contents [11585791] Antimicrob Agents Chemother. 2001 Dec;45(12):3647-50 [11709361] Vet Microbiol. 2002 Jan 3;84(1-2):143-53 [11731167] J Antimicrob Chemother. 2002 Jan;49(1):77-85 [11751770] J Am Vet Med Assoc. 2002 Jan 15;220(2):190-2 [12126128] Antimicrob Agents Chemother. 2002 Oct;46(10):3156-63 [12234838] J Clin Microbiol. 2002 Oct;40(10):3586-95 [12354850] Antimicrob Agents Chemother. 2002 Dec;46(12):3991-4 [12435708] FEMS Microbiol Lett. 2003 Mar 28;220(2):177-80 [12670678] Vet Microbiol. 2003 Jun 24;94(1):57-69 [12742716] Antimicrob Agents Chemother. 2004 Jan;48(1):1-14 [14693512] Microb Drug Resist. 2004 Spring;10(1):1-9 [15140388] Antimicrob Agents Chemother. 2004 Jun;48(6):2308-13 [15155242] Antimicrob Agents Chemother. 2004 Aug;48(8):2845-52 [15273090] J Antimicrob Chemother. 2004 Aug;54(2):321-32 [15254022] Clin Microbiol Rev. 1995 Oct;8(4):557-84 [8665470] Antimicrob Agents Chemother. 1995 Dec;39(12):2593-601 [8592985] Biophys J. 1998 Jul;75(1):422-7 [9649402] J Antimicrob Chemother. 1999 Apr;43(4):447-58 [10350372] Antimicrob Agents Chemother. 2005 Jan;49(1):358-65 [15616316] J Antimicrob Chemother. 2000 Jun;45(6):783-8 [10837430] Antimicrob Agents Chemother. 2005 Feb;49(2):833-5 [15673782] Antimicrob Agents Chemother. 2005 Mar;49(3):1262-4 [15728945] Emerg Infect Dis. 2005 Sep;11(9):1464-6 [16229784] Antimicrob Agents Chemother. 2005 Nov;49(11):4745-50 [16251320] J Microbiol Methods. 2005 Dec;63(3):219-28 [15935499] J Antimicrob Chemother. 2005 Dec;56(6):1107-10 [16239288] Infect Control Hosp Epidemiol. 2006 Mar;27(3):312-4 [16532423] Antimicrob Agents Chemother. 2006 Sep;50(9):3203-6 [16940132] Antimicrob Agents Chemother. 2006 Sep;50(9):3220-1 [16940136] J Antimicrob Chemother. 2006 Dec;58(6):1311-2 [17023496] Vet Microbiol. 2007 Apr 15;121(3-4):197-214 [17306475] FEMS Microbiol Lett. 2007 May;270(2):265-71 [17326753] Vet Microbiol. 2008 Feb 5;127(1-2):97-105 [17870255] J Antimicrob Chemother. 2008 Feb;61(2):273-81 [18077311] J Clin Microbiol. 2008 Mar;46(3):1110-2 [18184851] Vet Microbiol. 2008 May 25;129(1-2):203-8 [18166282] Antimicrob Agents Chemother. 2009 Jan;53(1):327-8 [19001117] Antimicrob Agents Chemother. 2009 Feb;53(2):519-24 [18936192] J Antimicrob Chemother. 2009 Oct;64(4):723-30 [19638354] J Antimicrob Chemother. 2009 Dec;64(6):1181-6 [19815633] J Clin Microbiol. 2010 Mar;48(3):883-8 [20032253] J Antimicrob Chemother. 2010 Apr;65(4):651-60 [20118165] J Vet Intern Med. 2010 Mar-Apr;24(2):323-30 [20102505] Antimicrob Agents Chemother. 2010 Aug;54(8):3489-92 [20479196] Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):283-8 [11114163] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AAC.00656-11 ER - TY - JOUR T1 - Reduced aldehyde dehydrogenase activity and arginine vasopressin receptor 2 expression in the kidneys of male TALLYHO/JngJ mice of prediabetic age. AN - 903149132; 21879339 AB - The TALLYHO/JngJ (TH) mouse is a novel polygenic model of type 2 diabetes and exhibits obesity, hyperglycemia (males), hyperinsulinemia, hyperlipidemia, and enlarged pancreatic islets. Since the kidney is damaged by hyperglycemia in other animal models, the present study aimed to determine the kidney phenotype of TH mice using immunoblot and histological analyses of the kidneys of 6-week-old (prediabetic) and 16-week-old TH mice. Interestingly, even 6-week-old male TH mice showed significant increases in kidney weight, compared to C57BL/B6 (B6) mice. Cuboidal parietal epithelium was observed in the Bowman's capsule in male TH mice at the prediabetic age. Water accumulated inside the kidneys of male TH mice in an age-dependent manner, but not in B6 mice. Since Swr/J mice are reported to develop diabetes insipidus and share 86.8% genotype homology with TH mice, the expression level of arginine vasopressin receptor 2 (AVPR2), a candidate protein for diabetes insipidus, was examined and determined to be significantly reduced in the kidneys of prediabetic male TH mice, compared to B6 mice. Aldehyde dehydrogenase (ALDH) activity in the kidneys of prediabetic male TH mice was significantly lower than that in age-matched male B6 mice, while there were no differences between female TH and B6 mice. These results suggest that the kidney phenotype of prediabetic TH mice occurs only in males, accompanied by a reduction in ALDH activity and AVPR2 expression. The kidney phenotype of male TH mice at a prediabetic age becomes evident before the onset of diabetes. JF - Endocrine AU - Nakamura, Noriko AD - Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Noriko.Nakamura@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 379 EP - 385 VL - 40 IS - 3 KW - Receptors, Vasopressin KW - 0 KW - Arginine Vasopressin KW - 113-79-1 KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Index Medicus KW - Bowman Capsule -- anatomy & histology KW - Mice, Inbred Strains KW - Animals KW - Reference Values KW - Sex Factors KW - Mice, Inbred C57BL KW - Case-Control Studies KW - Disease Models, Animal KW - Mice KW - Water-Electrolyte Balance KW - Organ Size KW - Male KW - Female KW - Matched-Pair Analysis KW - Receptors, Vasopressin -- metabolism KW - Kidney -- metabolism KW - Diabetes Mellitus, Type 2 -- metabolism KW - Diabetes Mellitus, Type 2 -- physiopathology KW - Aldehyde Dehydrogenase -- metabolism KW - Kidney -- physiopathology KW - Kidney -- anatomy & histology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/903149132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine&rft.atitle=Reduced+aldehyde+dehydrogenase+activity+and+arginine+vasopressin+receptor+2+expression+in+the+kidneys+of+male+TALLYHO%2FJngJ+mice+of+prediabetic+age.&rft.au=Nakamura%2C+Noriko&rft.aulast=Nakamura&rft.aufirst=Noriko&rft.date=2011-12-01&rft.volume=40&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Endocrine&rft.issn=1559-0100&rft_id=info:doi/10.1007%2Fs12020-011-9528-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-26 N1 - Date created - 2011-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s12020-011-9528-4 ER - TY - JOUR T1 - Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity. AN - 902331814; 21281223 AB - The goal was to determine if increasing welding voltage changes the physico-chemical properties of the fume and influences lung responses. Rats inhaled 40 mg/m³ (3 h/day × 3 days) of stainless steel (SS) welding fume generated at a standard voltage setting of 25 V (regular SS) or at a higher voltage (high voltage SS) of 30 V. Particle morphology, size and composition were characterized. Bronchoalveolar lavage was performed at different times after exposures to assess lung injury. Fumes collected from either of the welding conditions appeared as chain-like agglomerates of nanometer-sized primary particles. High voltage SS welding produced a greater number of ultrafine-sized particles. Fume generated by high voltage SS welding was higher in manganese. Pulmonary toxicity was more substantial and persisted longer after exposure to the regular SS fume. In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile. JF - Nanotoxicology AU - Antonini, James M AU - Keane, Michael AU - Chen, Bean T AU - Stone, Samuel AU - Roberts, Jenny R AU - Schwegler-Berry, Diane AU - Andrews, Ronnee N AU - Frazer, David G AU - Sriram, Krishnan AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. jga6@cdc.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 700 EP - 710 VL - 5 IS - 4 KW - Air Pollutants, Occupational KW - 0 KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Particle Size KW - Inhalation Exposure KW - Male KW - Microscopy, Electron, Scanning KW - Welding -- methods KW - Stainless Steel -- toxicity KW - Lung -- cytology KW - Lung -- chemistry KW - Lung -- drug effects KW - Air Pollutants, Occupational -- toxicity KW - Stainless Steel -- chemistry KW - Nanoparticles -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902331814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Alterations+in+welding+process+voltage+affect+the+generation+of+ultrafine+particles%2C+fume+composition%2C+and+pulmonary+toxicity.&rft.au=Antonini%2C+James+M%3BKeane%2C+Michael%3BChen%2C+Bean+T%3BStone%2C+Samuel%3BRoberts%2C+Jenny+R%3BSchwegler-Berry%2C+Diane%3BAndrews%2C+Ronnee+N%3BFrazer%2C+David+G%3BSriram%2C+Krishnan&rft.aulast=Antonini&rft.aufirst=James&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.550695 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-30 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.550695 ER - TY - JOUR T1 - Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments. AN - 902331808; 21261457 AB - Measurement of the surface area of airborne nanoparticles as administered to an experimental subject is critical for characterizing exposures during inhalation experiments. A filter-based surface area measurement methodology is described herein that allows for such determinations. Krypton gas adsorption was used to determine total particle surface area. Track-etched polycarbonate 0.4 μm pore filters were chosen as the collection substrate for metal oxide particles due to their highly reproducible surface areas and low background weights. The subject nanomaterials included two different batches of ultrafine TiO₂, TiO₂ nanorods, and SiO₂. The instrument detection limit for surface area was 200 cm² (0.02 m²). Ninety percent confidence interval estimates of method accuracy were 17.7-23.5% with a point estimate of 20.8%. The filter-based surface area measurement strategy is demonstrated to be a viable sampling and analysis methodology that provides much needed physical characterization information of particles as administered in an animal inhalation chamber. JF - Nanotoxicology AU - LeBuf, Ryan F AU - Stefaniak, Aleksandr B AU - Chen, Bean T AU - Frazer, David G AU - Virji, M Abbas AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA. rlebouf@cdc.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 687 EP - 699 VL - 5 IS - 4 KW - Aerosols KW - 0 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Microscopy, Electron, Transmission KW - Silicon Dioxide -- analysis KW - Titanium -- chemistry KW - Titanium -- analysis KW - Porosity KW - Linear Models KW - Toxicity Tests KW - Adsorption KW - Silicon Dioxide -- chemistry KW - Inhalation Exposure -- analysis KW - Nanoparticles -- analysis KW - Aerosols -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902331808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Measurement+of+airborne+nanoparticle+surface+area+using+a+filter-based+gas+adsorption+method+for+inhalation+toxicology+experiments.&rft.au=LeBuf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BVirji%2C+M+Abbas&rft.aulast=LeBuf&rft.aufirst=Ryan&rft.date=2011-12-01&rft.volume=5&rft.issue=4&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.546951 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-30 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.546951 ER - TY - JOUR T1 - Monitoring humans for somatic mutation in the endogenous PIG-a gene using red blood cells. AN - 902328846; 21826740 AB - The endogenous X-linked PIG-A gene is involved in the synthesis of glycosyl phosphatidyl inositol (GPI) anchors that tether specific protein markers to the exterior of mammalian cell cytoplasmic membranes. Earlier studies in rodent models indicate that Pig-a mutant red blood cells (RBCs) can be induced in animals treated with genotoxic agents, and that flow cytometry can be used to identify rare RBCs deficient in the GPI-anchored protein, CD59, as a marker of Pig-a gene mutation. We investigated if a similar approach could be used for detecting gene mutation in humans. We first determined the frequency of spontaneous CD59-deficient RBCs (presumed PIG-A mutants) in 97 self-identified healthy volunteers. For most subjects, the frequency of CD59-deficient RBCs was low (average of 5.1 ± 4.9 × 10(-6) ; median of 3.8 × 10(-6) and mutant frequency less than 8 × 10(-6) for 75% of subjects), with a statistically significant difference in median mutant frequencies between males and females. PIG-A RBC mutant frequency displayed poor correlation with the age and no correlation with the smoking status of the subjects. Also, two individuals had markedly increased CD59-deficient RBC frequencies of ∼300 × 10(-6) and ∼100 × 10(-6) . We then monitored PIG-A mutation in 10 newly diagnosed cancer patients undergoing chemotherapy with known genotoxic drugs. The frequency of CD59-deficient RBCs in the blood of the patients was measured before the start of chemotherapy and three times over a period of ∼6 months while on/after chemotherapy. Responses were generally weak, most observations being less than the median mutant frequency for both males and females; the greatest response was an approximate three-fold increase in the frequency of CD59-deficient RBCs in one patient treated with a combination of cisplatin and etoposide. These results suggest that the RBC PIG-A assay can be adopted to measuring somatic cell mutation in humans. Further research is necessary to determine the assay's sensitivity in detecting mutations induced by genotoxic agents acting via different mechanisms. Copyright © 2011 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Dobrovolsky, Vasily N AU - Elespuru, Rosalie K AU - Bigger, C Anita H AU - Robison, Timothy W AU - Heflich, Robert H AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, USA. vasily.dobrovolsky@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 784 EP - 794 VL - 52 IS - 9 KW - Antigens, CD59 KW - 0 KW - Antineoplastic Agents KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - CD59 protein, human KW - 101754-01-2 KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Flow Cytometry KW - Adolescent KW - Male KW - Female KW - Antigens, CD59 -- genetics KW - Erythrocytes -- drug effects KW - Genetic Testing -- methods KW - Antineoplastic Agents -- toxicity KW - Mutagens -- toxicity KW - Membrane Proteins -- genetics KW - Erythrocytes -- metabolism KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902328846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Monitoring+humans+for+somatic+mutation+in+the+endogenous+PIG-a+gene+using+red+blood+cells.&rft.au=Dobrovolsky%2C+Vasily+N%3BElespuru%2C+Rosalie+K%3BBigger%2C+C+Anita+H%3BRobison%2C+Timothy+W%3BHeflich%2C+Robert+H&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=784&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20667 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20667 ER - TY - JOUR T1 - Report on stage III Pig-a mutation assays using benzo[a]pyrene. AN - 902328778; 22052432 AB - Genotoxicity assays were conducted on rats treated with benzo[a]pyrene (BaP) as part of Stage III of a validation study on the Pig-a gene mutation assay. Assays were performed at the U.S. FDA-NCTR and Bayer-Germany. Starting on Day 1, groups of five 6- to 7-week-old male Fischer 344 (F344, used at FDA-NCTR) and Han Wistar rats (Bayer) were given 28 daily doses of 0, 37.5, 75, or 150 mg/kg BaP; blood was sampled on Days -1, 4, 15, 29, and 56. Pig-a mutant frequencies were determined on Days -1, 15, 29, and 56 in total red blood cells (RBCs) and reticulocytes (RETs) as RBC(CD59-) and RET(CD59-) frequencies; percent micronucleated-RETs (%MN-RET) were measured on Days 4 and 29. RBC(CD59-) and RET(CD59-) frequencies increased in a dose- and time-dependent manner, producing significant increases by Day 29 in both rat models. The responses for RETs were stronger than those for RBCs, and the responses in F344 rats were stronger than in Han Wistar rats. BaP also produced significant increases in %MN-RET frequency at Days 4 and 29, with the responses being greater in F344 than Han Wistar rats. The overall findings were consistent with those of the reference laboratory using Han Wistar rats. Finally, mutation assays performed on splenocytes from Day 56 F344 rats indicated that BaP mutant frequencies were three to fivefold higher for the Hprt gene than the Pig-a gene. The results indicate that the Pig-a RET and RBC assays are reproducible, transferable, and show promise for integrating gene mutation into 28-day repeat-dose studies. Copyright © 2011 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Bhalli, Javed A AU - Shaddock, Joseph G AU - Pearce, Mason G AU - Dobrovolsky, Vasily N AU - Cao, Xuefei AU - Heflich, Robert H AU - Vohr, Hans-Werner AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA. Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 731 EP - 737 VL - 52 IS - 9 KW - Antigens, CD59 KW - 0 KW - Membrane Proteins KW - Mutagens KW - phosphatidylinositol glycan-class A protein KW - Benzo(a)pyrene KW - 3417WMA06D KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Index Medicus KW - Erythrocytes -- drug effects KW - Animals KW - Endpoint Determination KW - Calibration KW - Reticulocytes -- ultrastructure KW - Risk Assessment KW - Erythrocytes -- ultrastructure KW - Rats KW - Reticulocytes -- drug effects KW - International Cooperation KW - Reticulocytes -- metabolism KW - Data Interpretation, Statistical KW - T-Lymphocytes -- drug effects KW - Time Factors KW - Comet Assay -- standards KW - Male KW - Micronucleus Tests -- methods KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Micronucleus Tests -- standards KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Reference Standards KW - Erythrocytes -- metabolism KW - Comet Assay -- methods KW - Laboratories -- standards KW - Antigens, CD59 -- genetics KW - T-Lymphocytes -- ultrastructure KW - Species Specificity KW - Mutagenicity Tests -- methods KW - Benzo(a)pyrene -- toxicity KW - Mutagens -- toxicity KW - Mutagenicity Tests -- standards KW - Membrane Proteins -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902328778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Report+on+stage+III+Pig-a+mutation+assays+using+benzo%5Ba%5Dpyrene.&rft.au=Bhalli%2C+Javed+A%3BShaddock%2C+Joseph+G%3BPearce%2C+Mason+G%3BDobrovolsky%2C+Vasily+N%3BCao%2C+Xuefei%3BHeflich%2C+Robert+H%3BVohr%2C+Hans-Werner&rft.aulast=Bhalli&rft.aufirst=Javed&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20675 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20675 ER - TY - JOUR T1 - Evaluation of false positive rate based on exposure-response analyses for two compounds in fixed-dose combination products AN - 1837304658; 16837051 AB - We explored the type I error rate (false positive rate) associated with exposure-response (ER) analyses for two compounds in a fixed-dose combination product through simulations. In the simulations, at least one compound was assumed to be inactive, whereas the active compound followed E sub(max) model at different concentration ranges. The simulated data were independently evaluated by pre-specified univariate or multivariate linear, log-linear models, and mixed linear log-linear models. The type I error rate was evaluated by comparing the total number of falsely identified significant slope estimates with the total number of models with successful convergence. We demonstrated that ER analyses results based on data from fixed-dose combination products at various dose levels should be interpreted with caution. A univariate analysis, even though is appropriate to guide dose selection, is inadequate to identify the active compound. Multivariate analyses can be applied to determine the active compound only when the underlying ER relationship for each compound (especially for the active compound) has been adequately defined or approximated. The false positive rate in determining a significant ER relationship is elevated, when the underlying ER relationship (especially for the active compound) is erroneously or inadequately defined. Without the assurance of the correct structural models, the identified significant ER relationship does not necessarily indicate that the compound associated with the significant slope estimate is pharmacologically active. JF - Journal of Pharmacokinetics and Biopharmaceutics AU - Zhu, Hao AU - Wang, Yaning AD - Division of Pharmacometrics, Office of Clinical Pharmacology, CDER, FDA, 10903 New Hampshire Avenue, Room 3150, Building 51, Silver Spring, MD, 20993, USA, Hao.Zhu@fda.hhs.gov Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 671 EP - 696 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 38 IS - 6 SN - 1567-567X, 1567-567X KW - Toxicology Abstracts KW - Data processing KW - Multivariate analysis KW - Convergence KW - Dose-response effects KW - Pharmacokinetics KW - Models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837304658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmacokinetics+and+Biopharmaceutics&rft.atitle=Evaluation+of+false+positive+rate+based+on+exposure-response+analyses+for+two+compounds+in+fixed-dose+combination+products&rft.au=Zhu%2C+Hao%3BWang%2C+Yaning&rft.aulast=Zhu&rft.aufirst=Hao&rft.date=2011-12-01&rft.volume=38&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmacokinetics+and+Biopharmaceutics&rft.issn=1567567X&rft_id=info:doi/10.1007%2Fs10928-011-9214-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Data processing; Convergence; Multivariate analysis; Dose-response effects; Pharmacokinetics; Models DO - http://dx.doi.org/10.1007/s10928-011-9214-4 ER - TY - JOUR T1 - Manifestation and persistence of Pig-a mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea AN - 1458535162; 16695251 AB - Treating rats with single doses of N-ethyl-N-nitrosourea (ENU) results in a time-dependent accumulation of Pig-a-mutant phenotype peripheral red blood cells (RBCs), reaching a plateau at about 6-weeks posttreatment, with the response persisting for at least 26 weeks. In the present study, groups of 5 C57BL/6 male mice were administered single i.p. doses of up to 140 mg/kg ENU, and blood samples were collected up to 26 weeks posttreatment. The samples were analyzed by flow cytometry for the frequency of CD24-deficient (presumed Pig-a mutant) reticulocytes (RETs) and total RBCs; micronucleated RET frequencies were evaluated at 1 day posttreatment. Mean Pig-a mutant frequencies and micronucleated RET frequencies increased in a dose-responsive manner, with maximum Pig-a frequencies in RETs and RBCs observed at Week 2 and Week 4 posttreatment, respectively. Mutant frequencies in RETs and RBCs generally decreased slowly with time after reaching their maxima. In a second experiment, groups of five male C57BL/6 mice were given single i.p. injections of 8, 32, or 160 mg/kg ENU, or four weekly doses of 8 or 40 mg/kg ENU (split doses totaling 32 and 160 mg/kg, respectively). In each case the maximum RET and RBC mutant frequencies produced by the split doses were similar to but not as great as the mutant frequencies produced by the equivalent single doses. The data indicate that ENU-induced Pig-a mutant RBC frequencies accumulate in mice as they do in rats; however, mice and rats differ in the manifestation kinetics and the persistence of the responses. ? Environ. Mol. Mutagen. 2011. Published 2011 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Bhalli, Javed A AU - Pearce, Mason G AU - Dobrovolsky, Vasily N AU - Heflich, Robert H Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 766 EP - 773 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 52 IS - 9 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts KW - Mutagens KW - Data processing KW - Erythrocytes KW - Mice KW - Mutant frequency KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Kinetics KW - Ethyl nitrosourea KW - Reticulocytes KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1458535162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Manifestation+and+persistence+of+Pig-a+mutant+red+blood+cells+in+C57BL%2F6+mice+following+single+and+split+doses+of+N-ethyl-N-nitrosourea&rft.au=Bhalli%2C+Javed+A%3BPearce%2C+Mason+G%3BDobrovolsky%2C+Vasily+N%3BHeflich%2C+Robert+H&rft.aulast=Bhalli&rft.aufirst=Javed&rft.date=2011-12-01&rft.volume=52&rft.issue=9&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20682 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20682/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-11-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Mutagens; Data processing; Kinetics; Erythrocytes; Ethyl nitrosourea; Mutant frequency; Reticulocytes; Mutagenesis; Rats; Mice; Mutants DO - http://dx.doi.org/10.1002/em.20682 ER - TY - JOUR T1 - Measuring surface area of airborne titanium dioxide powder agglomerates: relationships between gas adsorption, diffusion and mobility-based methods AN - 1439736904; 18524374 AB - Inhalation toxicology studies generally use the Brunauer, Emmett, and Teller (BET) gas adsorption method to measure total surface area of particles whereas occupational exposures are more readily measured by real-time mobility-based surface areas or active surface area measured with diffusion charger-based instruments. Three surface area measurement methods were studied: filter-based inert gas adsorption (BET method), diffusion charging, and mobility-based methods. The goal of the project was to investigate and develop a correlation between the measurement methods. The experimental design consisted of measuring surface area in a series of five trials for each of two powder types, fine and ultrafine titanium dioxide with primary particle sizes of 440 and 20 nm, respectively, and two aerosol concentrations. Diffusion charger instruments tended to underestimate the total particle surface area measured by the BET, but were well correlated with mobility-based surface areas obtained from a scanning mobility particle sizer. Filter-based gas adsorption methods and diffusion charging methods provide different but valuable information on total and active surface areas of particles, respectively. Results indicate they should not be used as predictors of one another. JF - Journal of Nanoparticle Research AU - LeBouf, Ryan F AU - Ku, Bon Ki AU - Chen, Bean T AU - Frazer, David G AU - Cumpston, Jared L AU - Stefaniak, Aleksandr B AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, 26505, USA, astefaniak@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 7029 EP - 7039 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 13 IS - 12 SN - 1388-0764, 1388-0764 KW - Health & Safety Science Abstracts KW - Aerosols KW - Titanium dioxide KW - Mobility KW - Surface area KW - Adsorption KW - Diffusion KW - Particulates KW - Measuring instruments KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439736904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanoparticle+Research&rft.atitle=Measuring+surface+area+of+airborne+titanium+dioxide+powder+agglomerates%3A+relationships+between+gas+adsorption%2C+diffusion+and+mobility-based+methods&rft.au=LeBouf%2C+Ryan+F%3BKu%2C+Bon+Ki%3BChen%2C+Bean+T%3BFrazer%2C+David+G%3BCumpston%2C+Jared+L%3BStefaniak%2C+Aleksandr+B&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2011-12-01&rft.volume=13&rft.issue=12&rft.spage=7029&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanoparticle+Research&rft.issn=13880764&rft_id=info:doi/10.1007%2Fs11051-011-0616-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Aerosols; Titanium dioxide; Mobility; Surface area; Adsorption; Diffusion; Measuring instruments; Particulates; Occupational exposure DO - http://dx.doi.org/10.1007/s11051-011-0616-4 ER - TY - RPRT T1 - Head Start Children, Families, and Programs: Present and Past Data from FACES. OPRE Report 2011-33a AN - 1314326102; ED539261 AB - This report provides a portrait of children entering Head Start for the first time in fall 2009, as well as of their family backgrounds and the classrooms and programs that serve them. The report also offers comparisons across the past decade of the Head Start program to delineate trends and changes in the population served and the services provided. Data are drawn from the Head Start Family and Child Experiences Survey (FACES), which was first launched in 1997 as a periodic, longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, and opinions; Head Start classroom practices and quality measures; and child and family outcomes. FACES includes a battery of child assessments across many developmental domains; interviews with children's parents, teachers, and program managers; and observations of classroom quality. In 2008, the Administration for Children and Families (ACF) funded Mathematica Policy Research and its partners--Educational Testing Service and Juarez and Associates--to design and conduct FACES 2009. (Contains 18 figures, 4 tables, and 61 notes.) AU - Hulsey, Lara Kristin AU - Aikens, Nikki AU - Kopack, Ashley AU - West, Jerry AU - Moiduddin, Emily AU - Tarullo, Louisa Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 44 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Research Reports KW - Classroom Environment KW - Teacher Attitudes KW - Preschool Tests KW - Credentials KW - Outcomes of Education KW - Classroom Observation Techniques KW - Child Development KW - Administrator Attitudes KW - Population Trends KW - Preschool Children KW - Teacher Qualifications KW - Preschool Evaluation KW - Educational Testing KW - Annual Reports KW - Longitudinal Studies KW - Cohort Analysis KW - Educational Practices KW - Opinions KW - Parent Attitudes KW - Interviews KW - Participant Characteristics KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1314326102?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Phylogenetic Status and Timescale for the Diversification of Steno and Sotalia Dolphins AN - 1311711296 AB - Molecular data have provided many insights into cetacean evolution but some unsettled issues still remain. We estimated the topology and timing of cetacean evolutionary relationships using Bayesian and maximum likelihood analyses of complete mitochondrial genomes. In order to clarify the phylogenetic placement of Sotalia and Steno within the Delphinidae, we sequenced three new delphinid mitogenomes. Our analyses support three delphinid clades: one joining Steno and Sotalia (supporting the revised subfamily Stenoninae); another placing Sousa within the Delphininae; and a third, the Globicephalinae, which includes Globicephala, Feresa, Pseudorca, Peponocephala and Grampus. We also conclude that Orcinus does not belong in the Globicephalinae, but Orcaella may be part of that subfamily. Divergence dates were estimated using the relaxed molecular clock calibrated with fossil data. We hypothesise that the timing of separation of the marine and Amazonian Sotalia species (2.3 Ma) coincided with the establishment of the modern Amazon River basin. JF - PLoS One AU - Cunha, Haydée A AU - Moraes, Lucas C AU - Medeiros, Bruna V AU - Lailson-Brito, José AU - Silva, M Fda AU - Solé-Cava, Antonio M AU - Schrago, Carlos G Y1 - 2011/12// PY - 2011 DA - Dec 2011 CY - San Francisco PB - Public Library of Science VL - 6 IS - 12 KW - Sciences: Comprehensive Works KW - Studies KW - Dolphins & porpoises KW - Evolution KW - Age KW - Genomes KW - Diversification KW - Phylogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1311711296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Phylogenetic+Status+and+Timescale+for+the+Diversification+of+Steno+and+Sotalia+Dolphins%3A+e28297&rft.au=Cunha%2C+Hayd%C3%A9e+A%3BMoraes%2C+Lucas+C%3BMedeiros%2C+Bruna+V%3BLailson-Brito%2C+Jos%C3%A9%3BSilva%2C+M+Fda%3BSol%C3%A9-Cava%2C+Antonio+M%3BSchrago%2C+Carlos+G&rft.aulast=Cunha&rft.aufirst=Hayd%C3%A9e&rft.date=2011-12-01&rft.volume=6&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0028297 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2011 Cunha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Cunha HA, Moraes LC, Medeiros BV, Lailson-Brito J Jr, da Silva VMF, et al. (2011) Phylogenetic Status and Timescale for the Diversification of Steno and Sotalia Dolphins. PLoS ONE 6(12): e28297. doi:10.1371/journal.pone.0028297 N1 - Last updated - 2013-02-25 DO - http://dx.doi.org/10.1371/journal.pone.0028297 ER - TY - JOUR T1 - Parenting Practices among Depressed Mothers in the Child Welfare System AN - 1221410286; 201208007 AB - The purpose of this study was to analyze a nationally representative sample of families referred to Child Protective Services (CPS) agencies, the National Survey of Child and Adolescent Well-Being, to examine the association between maternal depression and parenting practices over a 36-month follow-up period. Three hypotheses were tested: (1) Depressed mothers are more likely to demonstrate harsh parenting than are nondepressed mothers; (2) depressed mothers are more likely to demonstrate neglectful parenting than are nondepressed mothers; and (3) depressed mothers are more likely to demonstrate emotional maltreatment than are nondepressed mothers. The interaction between depression and time was also analyzed for each parenting practice to determine how changes in maternal depression affected changes in parenting. The sample for this study was 1,536 mother-child dyads in which the child was age three to 10 years and remained in the home after a CPS investigation. Depression remained high across time points and was associated with increased risk of emotional maltreatment and neglect over a 36-month period. In addition, self-reported emotional maltreatment remained high across time points. Implications of this work are the needs for better identification of mental health needs for mothers entering the child welfare system and parent training to specifically address positive parenting. Adapted from the source document. JF - Social Work Research AU - Kohl, Patricia L AU - Kagotho, Jacqueline Njeri AU - Dixon, David AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Missouri, USA pkohl@gwbmail.wustl.edu Y1 - 2011/12// PY - 2011 DA - December 2011 SP - 215 EP - 225 PB - Association of Social Workers, Washington DC VL - 35 IS - 4 SN - 1070-5309, 1070-5309 KW - child welfare, maternal depression, National Survey of Child and Adolescent Well-Being, parenting KW - Parent Training KW - Depression (Psychology) KW - Well Being KW - Child Welfare Services KW - Mothers KW - Family KW - Childrearing Practices KW - Children KW - Adolescents KW - article KW - 6111: social work theory/research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221410286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+Research&rft.atitle=Parenting+Practices+among+Depressed+Mothers+in+the+Child+Welfare+System&rft.au=Kohl%2C+Patricia+L%3BKagotho%2C+Jacqueline+Njeri%3BDixon%2C+David&rft.aulast=Kohl&rft.aufirst=Patricia&rft.date=2011-12-01&rft.volume=35&rft.issue=4&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Social+Work+Research&rft.issn=10705309&rft_id=info:doi/10.1093%2Fswr%2F35.4.215 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Mothers; Childrearing Practices; Child Welfare Services; Depression (Psychology); Children; Well Being; Family; Adolescents; Parent Training DO - http://dx.doi.org/10.1093/swr/35.4.215 ER - TY - JOUR T1 - Field evaluation of a new prototype self-contained breathing apparatus AN - 1038283499; 17045454 AB - Firefighters are required to use a self-contained breathing apparatus (SCBA) for respiratory protection when engaged in a variety of firefighting duties. While the SCBA provides crucial respiratory support and protection, it is also cumbersome and heavy, thus adding to the physical work performed by the firefighter. The purpose of the present study was to evaluate and compare the low profile SCBA prototype to a standard SCBA, as assessed by the objective and subjective measures of mobility and comfort, time of donning/doffing, as well as by acquiring user feedback on SCBA design features during field activities. The results of the present study indicated that the prototype SCBA was rated as a significant improvement over the standard SCBA in the areas of range of motion (ROM), mobility, comfort, induction of fatigue, interaction with protective clothing, and operability when worn over a standard firefighter ensemble, while performing a series of International Association of Fire Fighters Fire Ground Survival Program training exercises. Statement of Relevance: A prototype SCBA was evaluated and compared with a standard SCBA, focusing on the objective and subjective measures of mobility and comfort during field activities. Feedback from end users was collected during the evaluation. The findings of the present study can be used for improving the system design and overall performance of new prototype SCBAs. JF - Ergonomics AU - Coca, Aitor AU - Kim, Jung-Hyun AU - Duffy, Richard AU - Williams, WJon AD - CDC/NIOSH/NPPTL, Pittsburgh, PA, USA Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 1197 EP - 1206 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 54 IS - 12 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - self-contained breathing apparatus KW - range of motion KW - subjective perceptions KW - firefighters KW - Fires KW - Fatigue KW - firefighter services KW - Mobility KW - Prototypes KW - Survival KW - Ergonomics KW - Working conditions KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038283499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Field+evaluation+of+a+new+prototype+self-contained+breathing+apparatus&rft.au=Coca%2C+Aitor%3BKim%2C+Jung-Hyun%3BDuffy%2C+Richard%3BWilliams%2C+WJon&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2011-12-01&rft.volume=54&rft.issue=12&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2011.622797 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fires; Fatigue; Mobility; firefighter services; Prototypes; Survival; Working conditions; Ergonomics; International standardization DO - http://dx.doi.org/10.1080/00140139.2011.622797 ER - TY - JOUR T1 - Thirty years of AIDS in America: a story of infinite hope AN - 1024211222; 4310973 AB - The year 2011 marks the thirtieth anniversary of the first case reports in the United States of what we now know to be end-stage HIV disease. This chronological milestone provides an opportunity to reflect upon the changing context of the American HIV/AIDS epidemic. Using two seminal documents as a framework, the 1986 Institute of Medicine Report, 'Confronting AIDS,' and the 2010 National HIV/AIDS Strategy, this descriptive analysis details our accomplishments in addressing the domestic U.S. epidemic and outlines what remains to be done on the long road to eradication of HIV disease. The past three decades have witnessed tremendous biomedical and behavioral advances in preventing, diagnosing, and treating HIV disease. However, to fully realize the promise of these scientific advances, such that we achieve the vision of the National HIV/AIDS Strategy, we must develop effective strategies to surmount a number of salient challenges, including: unbalanced combinations of prevention interventions; programs that are not of adequate scale to achieve population-level results; systems of service delivery that do not function in an integrated fashion; and social and economic structures that increase the vulnerability of populations who are at risk for or living with HIV disease. Adapted from the source document. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Valdiserri, Ronald O AD - US Department of Health and Human Services Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 479 EP - 494 VL - 23 IS - 6 SN - 0899-9546, 0899-9546 KW - Sociology KW - Prevention KW - Epidemics KW - Economic structure KW - Biomedicine KW - AIDS KW - Medical treatment KW - Diseases KW - U.S.A. KW - HIV KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1024211222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Thirty+years+of+AIDS+in+America%3A+a+story+of+infinite+hope&rft.au=Valdiserri%2C+Ronald+O&rft.aulast=Valdiserri&rft.aufirst=Ronald&rft.date=2011-12-01&rft.volume=23&rft.issue=6&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 482 3617 6220; 10072; 1618 7894; 4014; 5703 3617 6220; 3617 6220; 10449 5772; 7890 5792 10484; 4356 3617 6220; 433 293 14 ER - TY - JOUR T1 - Update of the NIOSH life table analysis system: A person-years analysis program for the windows computing environment AN - 1017970867; 16691497 AB - Background Person-years analysis is a fundamental tool of occupational epidemiology. A life table analysis system (LTAS), previously developed by the National Institute for Occupational Safety and Health, was limited by its platform and analysis and reporting capabilities. We describe the updating of LTAS for the Windows operating system (LTAS.NET) with improved properties. Software Development Process A group of epidemiologists, programmers, and statisticians developed software, platform, and computing requirements. Statistical methods include the use of (indirectly) standardized mortality ratios, (directly) standardized rate ratios, confidence intervals, and P values based on the normal approximation and exact Poisson methods, and a trend estimator for linear exposure-response associations. Software Features We show examples using LTAS.NET to stratify and analyze multiple fixed and time-dependent variables. Data import, stratification, and reporting options are highly flexible. Users may export stratified data for Poisson regression modeling. Conclusions LTAS.NET incorporates improvements that will facilitate more complex person-years analysis of occupational cohort data. Am. J. Ind. Med. 54:915-924, 2011. ? 2011 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Schubauer-Berigan, Mary K AU - Hein, Misty J AU - Raudabaugh, William M AU - Ruder, Avima M AU - Silver, Sharon R AU - Spaeth, Steven AU - Steenland, Kyle AU - Petersen, Martin R AU - Waters, Kathleen M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, zcg3@cdc.gov Y1 - 2011/12// PY - 2011 DA - Dec 2011 SP - 915 EP - 924 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 12 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Computer programs KW - Mortality KW - exports KW - Dose-response effects KW - statisticians KW - Occupational safety KW - Standards KW - Stratification KW - imports KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Update+of+the+NIOSH+life+table+analysis+system%3A+A+person-years+analysis+program+for+the+windows+computing+environment&rft.au=Schubauer-Berigan%2C+Mary+K%3BHein%2C+Misty+J%3BRaudabaugh%2C+William+M%3BRuder%2C+Avima+M%3BSilver%2C+Sharon+R%3BSpaeth%2C+Steven%3BSteenland%2C+Kyle%3BPetersen%2C+Martin+R%3BWaters%2C+Kathleen+M&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2011-12-01&rft.volume=54&rft.issue=12&rft.spage=915&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20999 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20999/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Mortality; Computer programs; exports; statisticians; Dose-response effects; Occupational safety; Standards; Stratification; imports DO - http://dx.doi.org/10.1002/ajim.20999 ER - TY - JOUR T1 - In Utero Exposure to Maternal Tobacco Smoke and Subsequent Obesity, Hypertension, and Gestational Diabetes Among Women in The MoBa Cohort AN - 1660052983; 16537014 AB - Background: Environmental factors influencing the developmental origins of health and disease need to be identified and investigated. In utero exposure to tobacco smoke has been associated with obesity and a small increase in blood pressure in children; however, whether there is a corresponding increased risk of conditions such as diabetes and hypertension during adulthood remains unclear. Objective: Our goal was to assess the association of self-reported in utero exposure to tobacco smoke with the prevalence of obesity, hypertension, type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) in women 14-47 years of age. Methods: We conducted a cross-sectional analysis of the Norwegian Mother and Child Cohort Study, which enrolled pregnant women in Norway from 1999 thorough 2008. Exposure to tobacco smoke in utero (yes vs. no) was ascertained on the baseline questionnaire (obtained at ~ 17 weeks' gestation); the outcomes were ascertained from the Medical Birth Registry of Norway and the questionnaire. Our analysis included 74,023 women. Results: Women exposed to tobacco smoke in utero had 1.53 times the odds of obesity [95% confidence interval (CI): 1.45, 1.61] relative to those unexposed, after adjusting for age, education, and personal smoking. After further adjustment for body mass index, the odds ratio for hypertension was 1.68 (95% CI: 1.19, 2.39); for T2DM 1.14 (95% CI: 0.79, 1.65); and for GDM 1.32 (95% CI: 1.10, 1.58) among exposed compared with unexposed. Conclusions: Exposure to tobacco smoke in utero was associated with obesity, hypertension, and GDM in adult women. The possibility that the associations were attributable to unmeasured confounding cannot be excluded. JF - Environmental Health Perspectives AU - Cupul-Uicab, Lea A AU - Skjaerven, Rolv AU - Haug, Kjell AU - Melve, Kari K AU - Engel, Stephanie M AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/29/ PY - 2011 DA - 2011 Nov 29 SP - 355 EP - 360 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - diabetes mellitus KW - gestational diabetes KW - hypertension KW - in utero KW - maternal smoking KW - MoBa KW - obesity KW - tobacco smoke KW - Smoke KW - Diabetes mellitus KW - Obesity KW - Gestation KW - Tobacco KW - Health KW - Hypertension KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660052983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=In+Utero+Exposure+to+Maternal+Tobacco+Smoke+and+Subsequent+Obesity%2C+Hypertension%2C+and+Gestational+Diabetes+Among+Women+in+The+MoBa+Cohort&rft.au=Cupul-Uicab%2C+Lea+A%3BSkjaerven%2C+Rolv%3BHaug%2C+Kjell%3BMelve%2C+Kari+K%3BEngel%2C+Stephanie+M%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2011-11-29&rft.volume=120&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103789 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1103789 ER - TY - JOUR T1 - Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. AN - 906153348; 22001122 AB - Aluminum is a ubiquitous element that is released naturally into the environment via volcanic activity and the breakdown of rocks on the earth's surface. Exposure of the general population to aluminum occurs primarily through the consumption of food, antacids, and buffered analgesics. Exposure to aluminum in the general population can also occur through vaccination, since vaccines often contain aluminum salts (frequently aluminum hydroxide or aluminum phosphate) as adjuvants. Because concerns have been expressed by the public that aluminum in vaccines may pose a risk to infants, we developed an up-to-date analysis of the safety of aluminum adjuvants. Keith et al. [1] previously analyzed the pharmacokinetics of aluminum for infant dietary and vaccine exposures and compared the resulting body burdens to those based on the minimal risk levels (MRLs) established by the Agency for Toxic Substances and Disease Registry. We updated the analysis of Keith et al. [1] with a current pediatric vaccination schedule [2]; baseline aluminum levels at birth; an aluminum retention function that reflects changing glomerular filtration rates in infants; an adjustment for the kinetics of aluminum efflux at the site of injection; contemporaneous MRLs; and the most recent infant body weight data for children 0-60 months of age [3]. Using these updated parameters we found that the body burden of aluminum from vaccines and diet throughout an infant's first year of life is significantly less than the corresponding safe body burden of aluminum modeled using the regulatory MRL. We conclude that episodic exposures to vaccines that contain aluminum adjuvant continue to be extremely low risk to infants and that the benefits of using vaccines containing aluminum adjuvant outweigh any theoretical concerns. Published by Elsevier Ltd. JF - Vaccine AU - Mitkus, Robert J AU - King, David B AU - Hess, Maureen A AU - Forshee, Richard A AU - Walderhaug, Mark O AD - Office of Biostatistics and Epidemiology, USFDA Center for Biologics Evaluation and Research, 1401 Rockville Pike, HFM-210, Rockville, MD 20852, United States. Robert.Mitkus@fda.hhs.gov Y1 - 2011/11/28/ PY - 2011 DA - 2011 Nov 28 SP - 9538 EP - 9543 VL - 29 IS - 51 KW - Adjuvants, Immunologic KW - 0 KW - Aluminum KW - CPD4NFA903 KW - Index Medicus KW - Humans KW - Aluminum -- adverse effects KW - Vaccination -- adverse effects KW - Aluminum -- pharmacokinetics KW - Adjuvants, Immunologic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/906153348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Updated+aluminum+pharmacokinetics+following+infant+exposures+through+diet+and+vaccination.&rft.au=Mitkus%2C+Robert+J%3BKing%2C+David+B%3BHess%2C+Maureen+A%3BForshee%2C+Richard+A%3BWalderhaug%2C+Mark+O&rft.aulast=Mitkus&rft.aufirst=Robert&rft.date=2011-11-28&rft.volume=29&rft.issue=51&rft.spage=9538&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2011.09.124 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-22 N1 - Date created - 2011-11-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Vaccine. 2002 May 31;20 Suppl 3:S13-7 [12184359] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.vaccine.2011.09.124 ER - TY - CPAPER T1 - Terminology Standardization in CT: Progress and Challenges T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313064019; 6070633 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Mills, Thalia Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Standardization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313064019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Terminology+Standardization+in+CT%3A+Progress+and+Challenges&rft.au=Mills%2C+Thalia&rft.aulast=Mills&rft.aufirst=Thalia&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - FDA Dose Reduction Initiative: CT Progress T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313028779; 6069165 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Stern, Stanley Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313028779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=FDA+Dose+Reduction+Initiative%3A+CT+Progress&rft.au=Stern%2C+Stanley&rft.aulast=Stern&rft.aufirst=Stanley&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Effect of Overlapping Reconstruction on Lung Nodule Volume Estimation with Multidetector CT T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1313016173; 6071162 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Gavrielides, M AU - Zeng, R AU - Sahiner, B AU - Myers, K AU - Petrick, N Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Lung nodules KW - Nodules UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Effect+of+Overlapping+Reconstruction+on+Lung+Nodule+Volume+Estimation+with+Multidetector+CT&rft.au=Gavrielides%2C+M%3BZeng%2C+R%3BSahiner%2C+B%3BMyers%2C+K%3BPetrick%2C+N&rft.aulast=Gavrielides&rft.aufirst=M&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Emerging CAD Applications T2 - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AN - 1312999707; 6072217 JF - 97th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2011) AU - Sahiner, Berkman Y1 - 2011/11/27/ PY - 2011 DA - 2011 Nov 27 KW - Technology KW - Nuclear medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312999707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.atitle=Emerging+CAD+Applications&rft.au=Sahiner%2C+Berkman&rft.aulast=Sahiner&rft.aufirst=Berkman&rft.date=2011-11-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=97th+Scientific+Assembly+and+Annual+Meeting+of+the+Radiological+Society+of+North+America+%28RSNA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://rsna2011.rsna.org/search/search.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Transcriptional activity of DNMT3B in pancreatic cancer cells: effects of -149 (C→T) promoter polymorphism. AN - 905679009; 21854760 AB - Polymorphic C-to-T change in the promoter region of DNA-methyltransferase-3B (DNMT3B) gene is associated with risk of several cancers. The aim of this study was to investigate the effect of DNMT3B promoter genetic variant on its transcriptional activity and to compare activity in several pancreatic cell lines. DNMT3B promoter constructs carrying either -149C allele or -149T allele were transiently transfected into pancreatic cancer cells. In promoter assaying, carriage of -149T allele showed only a slight activity (1.1-fold) in Mia cells (p=0.462). In contrast, significant increase (3.8-fold) in activity of -149T allele was shown in SU86.86 pancreatic cancer cells (p=0.0001). These preliminary findings suggest that genetic variance may influence DNMT3B expression in pancreatic cancer. Further studies are needed. Published by Elsevier Inc. JF - Biochemical and biophysical research communications AU - Xiao, Yongmei AU - Word, Beverly AU - Hammons, George AU - Lyn-Cook, Beverly AD - Office of Regulatory Activities, National Center for Toxicological Research, Jefferson, AR 72079, United States. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 220 EP - 223 VL - 415 IS - 2 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA methyltransferase 3B KW - Index Medicus KW - DNA Methylation KW - Humans KW - Transcription, Genetic KW - Promoter Regions, Genetic -- genetics KW - Cell Line, Tumor KW - Gene Expression Regulation, Neoplastic KW - DNA (Cytosine-5-)-Methyltransferase -- genetics KW - Gene Expression Regulation, Enzymologic KW - Pancreatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/905679009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Transcriptional+activity+of+DNMT3B+in+pancreatic+cancer+cells%3A+effects+of+-149+%28C%E2%86%92T%29+promoter+polymorphism.&rft.au=Xiao%2C+Yongmei%3BWord%2C+Beverly%3BHammons%2C+George%3BLyn-Cook%2C+Beverly&rft.aulast=Xiao&rft.aufirst=Yongmei&rft.date=2011-11-18&rft.volume=415&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=1090-2104&rft_id=info:doi/10.1016%2Fj.bbrc.2011.07.115 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-18 N1 - Date created - 2011-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.bbrc.2011.07.115 ER - TY - JOUR T1 - Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. AN - 904007534; 21884834 AB - Human exposure to nanoparticles is inevitable from natural and anthropogenic sources. Titanium dioxide (TiO2) nanoparticles are increasingly being used in pharmaceutical and cosmetic products. Previous studies revealed that TiO2 levels were significantly increased in tissues (e.g., lymph nodes) after mice were injected with nanosized TiO2. To identify early response lymph node proteins to TiO2 nanoparticles, groups of mice were intradermally injected with a low dose of DeGussa P25 TiO2 nanoparticles or vehicle alone. The proteomes of lymph nodes at 24 h were quantitatively analyzed using trypsin-catalyzed 16O/18O labeling in conjunction with two-dimensional liquid chromatography separation and tandem mass spectrometry (2DLC-MS/MS). A total of 33 proteins were significantly changed (over 1.3-fold, p<0.05) in the mice treated with TiO2 nanoparticles, which accounted for approximately 1% of the total proteins identified. The differentially expressed proteins mainly involve the immune response (e.g., inflammation), lipid and fatty acid metabolism, mRNA processing, and nucleosome assembly. Regulation of functionally distinct classes of proteins could be mediated by estrogen receptor (ESR1), PPARγ, and c-Myc signalings, etc. The differentially expressed proteins identified in this experiment could represent early response proteins to TiO2 nanoparticle treatment in mouse lymph nodes. Published by Elsevier B.V. JF - Journal of proteomics AU - Gao, Yuan AU - Gopee, Neera V AU - Howard, Paul C AU - Yu, Li-Rong AD - Center of Excellence for Proteomics, Division of Systems Biology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2011/11/18/ PY - 2011 DA - 2011 Nov 18 SP - 2745 EP - 2759 VL - 74 IS - 12 KW - Biocompatible Materials KW - 0 KW - Proteome KW - titanium dioxide KW - 15FIX9V2JP KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Female KW - Proteomics -- methods KW - Lymph Nodes -- metabolism KW - Titanium -- administration & dosage KW - Biocompatible Materials -- administration & dosage KW - Gene Expression Regulation -- immunology KW - Proteome -- metabolism KW - Gene Expression Regulation -- drug effects KW - Nanoparticles -- administration & dosage KW - Proteome -- immunology KW - Lymph Nodes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904007534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+proteomics&rft.atitle=Proteomic+analysis+of+early+response+lymph+node+proteins+in+mice+treated+with+titanium+dioxide+nanoparticles.&rft.au=Gao%2C+Yuan%3BGopee%2C+Neera+V%3BHoward%2C+Paul+C%3BYu%2C+Li-Rong&rft.aulast=Gao&rft.aufirst=Yuan&rft.date=2011-11-18&rft.volume=74&rft.issue=12&rft.spage=2745&rft.isbn=&rft.btitle=&rft.title=Journal+of+proteomics&rft.issn=1876-7737&rft_id=info:doi/10.1016%2Fj.jprot.2011.08.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-03-01 N1 - Date created - 2011-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomed Nanotechnol. 2010 Feb;6(1):1-19 [20499827] Curr Opin Biotechnol. 2007 Dec;18(6):565-71 [18160274] Adv Mater. 2010 Jun 25;22(24):2601-27 [20512811] Nat Biotechnol. 2010 Dec;28(12):1300-3 [21057497] Mol Cell Proteomics. 2011 Jan;10(1):M110.003335 [20807836] Arch Toxicol. 2008 Mar;82(3):151-7 [18000654] Eur J Immunol. 2008 May;38(5):1404-13 [18389478] Environ Mol Mutagen. 2008 Jun;49(5):399-405 [18418868] Biochem Biophys Res Commun. 2008 Aug 22;373(2):315-8 [18571499] Nat Nanotechnol. 2007 Aug;2(8):469-78 [18654343] Br J Cancer. 2008 Aug 5;99(3):392-7 [18648371] J Toxicol Sci. 2008 Aug;33(3):293-8 [18670160] Nano Lett. 2008 Sep;8(9):2779-87 [18687009] Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14265-70 [18809927] Genes Dev. 2008 Nov 1;22(21):2953-67 [18981474] J Hazard Mater. 2009 Feb 15;162(1):57-65 [18554790] J Proteome Res. 2009 May;8(5):2140-3 [19338309] Mol Cell Proteomics. 2009 May;8(5):1130-49 [19181660] J Proteome Res. 2009 May;8(5):2157-63 [19222237] Toxicol Sci. 2009 Sep;111(1):37-48 [19574408] Cancer Res. 2009 Nov 15;69(22):8784-9 [19887611] Environ Sci Pollut Res Int. 2010 Mar;17(3):798-806 [19390888] Nanotechnology. 2010 Mar 26;21(12):125105 [20203358] Toxicol Sci. 2010 May;115(1):156-66 [20156837] Toxicol Lett. 2010 Jun 2;195(2-3):161-8 [20381595] Int J Pharm. 2000 Mar 10;196(2):245-9 [10699728] J Biol Chem. 2001 Oct 12;276(41):37731-4 [11459852] Rapid Commun Mass Spectrom. 2001;15(24):2456-65 [11746917] Electrophoresis. 2002 Jan;23(2):356-62 [11840544] Nat Biotechnol. 2004 Jan;22(1):93-7 [14661026] Proteomics. 2004 Mar;4(3):753-65 [14997497] Eur J Immunol. 1992 Jul;22(7):1891-7 [1378023] Electrophoresis. 1996 May;17(5):945-53 [8783021] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11509-10 [9751695] Biochim Biophys Acta. 1998 Dec 10;1448(2):200-11 [9920411] J Proteome Res. 2005 Mar-Apr;4(2):523-31 [15822930] Environ Health Perspect. 2005 Jul;113(7):823-39 [16002369] Toxicol Sci. 2006 May;91(1):227-36 [16495353] Proteomics. 2006 Jul;6(13):3833-44 [16767787] EMBO J. 2006 Oct 18;25(20):4854-64 [17024186] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Nature. 2006 Nov 16;444(7117):267-9 [17108940] Rapid Commun Mass Spectrom. 2006;20(23):3491-7 [17072904] Curr Opin Biotechnol. 2006 Dec;17(6):562-8 [17015011] Proteomics. 2007 Jan;7(2):220-31 [17163576] Toxicology. 2007 Jan 25;230(1):90-104 [17196727] Biochem Biophys Res Commun. 2007 May 18;356(4):942-7 [17395154] Toxicol Sci. 2007 Jul;98(1):249-57 [17404394] Nat Biotechnol. 2007 Oct;25(10):1159-64 [17873867] N Engl J Med. 2007 Oct 11;357(15):1469-72 [17928593] J Proteome Res. 2007 Nov;6(11):4150-62 [17924679] ACS Nano. 2010 Jun 22;4(6):3363-73 [20481555] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jprot.2011.08.009 ER - TY - JOUR T1 - Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans AN - 911168516; 16076121 AB - A physiologically based pharmacokinetic (PBPK) model was developed for bisphenol A (BPA) in adult rhesus monkeys using intravenous (iv) and oral bolus doses of 100 mu gd6-BPA/kg (). This calibrated PBPK adult monkey model for BPA was then evaluated against published monkey kinetic studies with BPA. Using two versions of the adult monkey model based on monkey BPA kinetic data from and , the aglycone BPA pharmacokinetics were simulated for human oral ingestion of 5mg d16-BPA per person (Volkel et al., 2002). Volkel et al. were unable to detect the aglycone BPA in plasma, but were able to detect BPA metabolites. These human model predictions of the aglycone BPA in plasma were then compared to previously published PBPK model predictions obtained by simulating the Volkel et al. kinetic study. Our BPA human model, using two parameter sets reflecting two adult monkey studies, both predicted lower aglycone levels in human serum than the previous human BPA PBPK model predictions. BPA was metabolized at all ages of monkey (PND 5 to adult) by the gut wall and liver. However, the hepatic metabolism of BPA and systemic clearance of its phase II metabolites appear to be slower in younger monkeys than adults. The use of the current non-human primate BPA model parameters provides more confidence in predicting the aglycone BPA in serum levels in humans after oral ingestion of BPA. JF - Toxicology and Applied Pharmacology AU - Fisher, Jeffrey W AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Doerge, Daniel R AD - Food & Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology , 3900 NCTR Road, Jefferson, AR 72079, USA, jeffrey.fisher@fda.hhs.gov Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 122 EP - 136 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 257 IS - 1 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Metabolites KW - Bisphenol A KW - Macaca mulatta KW - bisphenol A KW - Aglycones KW - Intravenous administration KW - Data processing KW - Dosimetry KW - Ingestion KW - Primates KW - Pharmacokinetics KW - Serum levels KW - Digestive tract KW - Kinetics KW - Liver KW - Metabolism KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetic+modeling%3A+Prediction+and+evaluation+of+route+dependent+dosimetry+of+bisphenol+A+in+monkeys+with+extrapolation+to+humans&rft.au=Fisher%2C+Jeffrey+W%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Fisher&rft.aufirst=Jeffrey&rft.date=2011-11-15&rft.volume=257&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.08.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Serum levels; Bisphenol A; Age; Intravenous administration; Aglycones; Data processing; Digestive tract; Kinetics; Dosimetry; Liver; Metabolites; Pharmacokinetics; bisphenol A; Ingestion; Metabolism; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.taap.2011.08.026 ER - TY - JOUR T1 - A novel combination immunotherapy for cancer by IL-13Rα2-targeted DNA vaccine and immunotoxin in murine tumor models. AN - 902340963; 22013118 AB - Optimum efficacy of therapeutic cancer vaccines may require combinations that generate effective antitumor immune responses, as well as overcome immune evasion and tolerance mechanisms mediated by progressing tumor. Previous studies showed that IL-13Rα2, a unique tumor-associated Ag, is a promising target for cancer immunotherapy. A targeted cytotoxin composed of IL-13 and mutated Pseudomonas exotoxin induced specific killing of IL-13Rα2(+) tumor cells. When combined with IL-13Rα2 DNA cancer vaccine, surprisingly, it mediated synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. The mechanism of synergistic activity involved direct killing of tumor cells and cell-mediated immune responses, as well as elimination of myeloid-derived suppressor cells and, consequently, regulatory T cells. These novel results provide a strong rationale for combining immunotoxins with cancer vaccines for the treatment of patients with advanced cancer. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Nakashima, Hideyuki AU - Terabe, Masaki AU - Berzofsky, Jay A AU - Husain, Syed R AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2011/11/15/ PY - 2011 DA - 2011 Nov 15 SP - 4935 EP - 4946 VL - 187 IS - 10 KW - Bacterial Toxins KW - 0 KW - Cancer Vaccines KW - Exotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Vaccines, DNA KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Cell Line, Tumor KW - Mice, Inbred BALB C KW - Drug Synergism KW - Female KW - Mice, Knockout KW - Vaccines, DNA -- immunology KW - Vaccines, DNA -- therapeutic use KW - Sarcoma, Experimental -- genetics KW - Interleukin-13 Receptor alpha2 Subunit -- biosynthesis KW - ADP Ribose Transferases -- genetics KW - Mammary Neoplasms, Experimental -- therapy KW - Bacterial Toxins -- genetics KW - Cancer Vaccines -- immunology KW - Bacterial Toxins -- therapeutic use KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Exotoxins -- genetics KW - ADP Ribose Transferases -- immunology KW - Gene Targeting -- methods KW - Virulence Factors -- therapeutic use KW - Cancer Vaccines -- therapeutic use KW - Mammary Neoplasms, Experimental -- genetics KW - Virulence Factors -- genetics KW - Exotoxins -- immunology KW - Bacterial Toxins -- immunology KW - Virulence Factors -- immunology KW - ADP Ribose Transferases -- therapeutic use KW - Immunotherapy -- methods KW - Interleukin-13 Receptor alpha2 Subunit -- therapeutic use KW - Sarcoma, Experimental -- therapy KW - Cancer Vaccines -- genetics KW - Exotoxins -- therapeutic use KW - Mammary Neoplasms, Experimental -- immunology KW - Sarcoma, Experimental -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902340963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=A+novel+combination+immunotherapy+for+cancer+by+IL-13R%CE%B12-targeted+DNA+vaccine+and+immunotoxin+in+murine+tumor+models.&rft.au=Nakashima%2C+Hideyuki%3BTerabe%2C+Masaki%3BBerzofsky%2C+Jay+A%3BHusain%2C+Syed+R%3BPuri%2C+Raj+K&rft.aulast=Nakashima&rft.aufirst=Hideyuki&rft.date=2011-11-15&rft.volume=187&rft.issue=10&rft.spage=4935&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=1550-6606&rft_id=info:doi/10.4049%2Fjimmunol.1102095 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-09 N1 - Date created - 2011-11-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell. 1992 Mar 6;68(5):855-67 [1547487] Cancer Res. 1992 Mar 15;52(6):1399-405 [1540948] Blood. 1996 May 15;87(10):4333-9 [8639793] J Biol Chem. 1996 Jul 12;271(28):16921-6 [8663118] Tissue Antigens. 1996 May;47(5):414-21 [8795142] J Clin Invest. 1998 Feb 15;101(4):746-54 [9466968] Clin Cancer Res. 1997 Feb;3(2):151-6 [9815666] J Immunol. 2005 Jan 15;174(2):636-45 [15634881] Protein Expr Purif. 2005 Feb;39(2):189-98 [15642470] Cancer Res. 2005 Apr 15;65(8):3044-8 [15833831] Curr Top Microbiol Immunol. 2005;293:287-302 [15981485] Nat Rev Immunol. 2005 Aug;5(8):641-54 [16056256] Cancer Res. 2005 Sep 15;65(18):8059-64 [16166275] Clin Cancer Res. 2005 Sep 15;11(18):6713-21 [16166452] Cancer Res. 2006 Jan 15;66(2):1123-31 [16424049] Cancer Res. 2006 Apr 15;66(8):4434-42 [16618770] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Clin Cancer Res. 2006 Aug 1;12(15):4678-86 [16899618] J Clin Invest. 2006 Oct;116(10):2587-90 [17016554] J Clin Invest. 2006 Oct;116(10):2777-90 [17016559] J Exp Med. 2006 Nov 27;203(12):2691-702 [17101732] Annu Rev Med. 2007;58:221-37 [17059365] J Clin Oncol. 2007 Mar 1;25(7):837-44 [17327604] Annu Rev Immunol. 2007;25:267-96 [17134371] Cancer Res. 2007 Jun 1;67(11):5067-9 [17545581] Vaccine. 2007 Sep 27;25 Suppl 2:B89-96 [17573164] Nat Rev Cancer. 2008 Feb;8(2):108-20 [18219306] Cancer Immunol Immunother. 2009 Jan;58(1):49-59 [18446337] Int J Cancer. 2009 Mar 15;124(6):1440-8 [19065664] Nat Rev Immunol. 2009 Mar;9(3):162-74 [19197294] Cancer Res. 2009 Nov 15;69(22):8678-85 [19887609] J Transl Med. 2010;8:116 [21067607] Int J Cancer. 2011 Mar 1;128(5):1221-31 [20473925] Clin Cancer Res. 2011 Jun 1;17(11):3520-6 [21471425] J Immunol. 2000 Mar 15;164(6):3112-22 [10706701] Cancer Res. 2000 Mar 1;60(5):1168-72 [10728667] Int J Cancer. 2001 Apr 15;92(2):168-75 [11291041] J Immunol. 2001 May 1;166(9):5398-406 [11313376] Vaccine. 2002 Dec 19;20 Suppl 4:A2-7 [12477422] Cancer Res. 2003 Aug 1;63(15):4441-9 [12907617] J Immunol. 2003 Sep 15;171(6):2889-95 [12960311] J Immunol. 2004 Feb 1;172(3):1540-7 [14734732] Cancer. 2004 Sep 1;101(5):1036-42 [15329913] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 1995 Nov 1;182(5):1301-14 [7595201] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4049/jimmunol.1102095 ER - TY - CPAPER T1 - Multiplex PCR for the detection of insects in food T2 - 59th Annual Meeting of the Entomological Society of America AN - 1313021832; 6063195 JF - 59th Annual Meeting of the Entomological Society of America AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Miller, Amy AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - insects KW - Polymerase chain reaction KW - Food KW - Aquatic insects KW - Nucleotide sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Multiplex+PCR+for+the+detection+of+insects+in+food&rft.au=Pava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BMiller%2C+Amy%3BZiobro%2C+George&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Could incidental storage insect pests be potential food allergens? T2 - 59th Annual Meeting of the Entomological Society of America AN - 1313021590; 6063191 JF - 59th Annual Meeting of the Entomological Society of America AU - Goeriz Pearson, Rachel AU - Pava-Ripoll, Monica AU - Miller, Amy AU - Opit, George AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - pests KW - Storage KW - Allergens KW - insects KW - Food hypersensitivity KW - Pests KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313021590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Could+incidental+storage+insect+pests+be+potential+food+allergens%3F&rft.au=Goeriz+Pearson%2C+Rachel%3BPava-Ripoll%2C+Monica%3BMiller%2C+Amy%3BOpit%2C+George%3BZiobro%2C+George&rft.aulast=Goeriz+Pearson&rft.aufirst=Rachel&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Are foodborne pathogens vertically transmitted in the house fly? T2 - 59th Annual Meeting of the Entomological Society of America AN - 1312918654; 6062892 JF - 59th Annual Meeting of the Entomological Society of America AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Miller, Amy AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - Residential areas KW - Pathogens KW - Housing KW - Food KW - Disease transmission UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312918654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Are+foodborne+pathogens+vertically+transmitted+in+the+house+fly%3F&rft.au=Pava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BMiller%2C+Amy%3BZiobro%2C+George&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Study of a non-flammable liquid as an insect preservative T2 - 59th Annual Meeting of the Entomological Society of America AN - 1312915855; 6063060 JF - 59th Annual Meeting of the Entomological Society of America AU - Miller, Amy AU - Pava-Ripoll, Monica AU - Goeriz Pearson, Rachel AU - Ziobro, George Y1 - 2011/11/13/ PY - 2011 DA - 2011 Nov 13 KW - Preservatives KW - insects KW - Aquatic insects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312915855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Study+of+a+non-flammable+liquid+as+an+insect+preservative&rft.au=Miller%2C+Amy%3BPava-Ripoll%2C+Monica%3BGoeriz+Pearson%2C+Rachel%3BZiobro%2C+George&rft.aulast=Miller&rft.aufirst=Amy&rft.date=2011-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2011/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Age-related blood-brain barrier dysfunction from substances of abuse T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313093088; 6103711 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Trickler, W AU - Robinson, B AU - Lantz, S AU - Newport, G AU - Schlager, J AU - Paule, M AU - Slikker, Jr., W. AU - Hussain, S AU - Ali, S Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Drug abuse KW - Blood-brain barrier KW - Age UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313093088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Age-related+blood-brain+barrier+dysfunction+from+substances+of+abuse&rft.au=Trickler%2C+W%3BRobinson%2C+B%3BLantz%2C+S%3BNewport%2C+G%3BSchlager%2C+J%3BPaule%2C+M%3BSlikker%2C+Jr.%2C+W.%3BHussain%2C+S%3BAli%2C+S&rft.aulast=Trickler&rft.aufirst=W&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Changes in gene expression profile in response to inhalation anesthesia in developing rat brain T2 - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AN - 1313004244; 6103250 JF - 2011 Annual meeting of the Society for Neuroscience (Neuroscience 2011) AU - Paule, M AU - Liu, F AU - Lei, G AU - Shi, L AU - Zhang, J AU - Sadovova, N AU - Hanig, J AU - Slikker, Jr., W. AU - Wang, C Y1 - 2011/11/12/ PY - 2011 DA - 2011 Nov 12 KW - Inhalation KW - Brain KW - anesthesia KW - Gene expression KW - Anesthesia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313004244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.atitle=Changes+in+gene+expression+profile+in+response+to+inhalation+anesthesia+in+developing+rat+brain&rft.au=Paule%2C+M%3BLiu%2C+F%3BLei%2C+G%3BShi%2C+L%3BZhang%2C+J%3BSadovova%2C+N%3BHanig%2C+J%3BSlikker%2C+Jr.%2C+W.%3BWang%2C+C&rft.aulast=Paule&rft.aufirst=M&rft.date=2011-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+meeting+of+the+Society+for+Neuroscience+%28Neuroscience+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sfn.org/am2011/index.aspx?pagename=final_program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Noise and Hearing Loss Prevention Workshop T2 - 2011 ASME International Mechanical Engineering Congress & Exposition (ASME 2011) AN - 1312987688; 6114032 JF - 2011 ASME International Mechanical Engineering Congress & Exposition (ASME 2011) AU - Azman, Amanda Y1 - 2011/11/11/ PY - 2011 DA - 2011 Nov 11 KW - Hearing loss KW - Prevention KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312987688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+ASME+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2011%29&rft.atitle=Noise+and+Hearing+Loss+Prevention+Workshop&rft.au=Azman%2C+Amanda&rft.aulast=Azman&rft.aufirst=Amanda&rft.date=2011-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+ASME+International+Mechanical+Engineering+Congress+%26+Exposition+%28ASME+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asmeconferences.org/Congress2011/TechnicalProgramOverview.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Preparative separation of 1,3,6-pyrenetrisulfonic acid trisodium salt from the color additive D&; C Green No. 8 (pyranine) by pH-zone-refining counter-current chromatography AN - 1266755407; 15913333 AB - In developing analytical methods for batch certification of the color additive D&C Green No. 8 (G8), the U.S. Food and Drug Administration needed the trisodium salt of 1,3,6-pyrenetrisulfonic acid (P3S) for use as a reference material. Since P3S was not commercially available, preparative quantities of it were separated from portions of a sample of G8 that contained [approx]3.5% P3S. The separations were performed by pH-zone-refining counter-current chromatography using dodecylamine (DA) as the hydrophobic counterion. The added DA enabled partitioning of the polysulfonated components into the organic stationary phase of the two-phase solvent system used, 1-butanol-water (1:1). Thus, a typical separation that involved 20.3 g of G8, using sulfuric acid as the retainer acid and 20% DA in the stationary phase and 0.1 M sodium hydroxide as the mobile phase, resulted in [approx]0.58 g of P3S of greater than 99% purity. The identification and characterization of the separated P3S were performed by elemental analyses, proton nuclear magnetic resonance, high-resolution mass spectrometry, ultra-violet spectra, and high-performance liquid chromatography. JF - Journal of Chromatography A AU - Weisz, Adrian AU - Mazzola, Eugene P AU - Ito, Yoichiro AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, HFS-106, 5100 Paint Branch Parkway, College Park, MD 20740, USA, adrian.weisz@fda.hhs.gov Y1 - 2011/11/11/ PY - 2011 DA - 2011 Nov 11 SP - 8249 EP - 8254 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 45 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Counter-current chromatography KW - pH-zone-refining CCC KW - Pyranine KW - D&C Green No. 8 KW - Dyes KW - 8-Hydroxy-1,3,6-pyrenetrisulfonic acid KW - 1,3,6-Pyrenetrisulfonic acid KW - Mass Spectrometry KW - Chromatographic techniques KW - Colour KW - Certification KW - Drugs KW - Sulfuric Acid KW - Chromatography KW - Solvents KW - Color KW - Salts KW - Foods KW - Analytical Methods KW - Acids KW - Hydroxides KW - Nuclear magnetic resonance KW - Additives KW - Sulphuric acid KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266755407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Preparative+separation+of+1%2C3%2C6-pyrenetrisulfonic+acid+trisodium+salt+from+the+color+additive+D%26amp%3B%3B+C+Green+No.+8+%28pyranine%29+by+pH-zone-refining+counter-current+chromatography&rft.au=Weisz%2C+Adrian%3BMazzola%2C+Eugene+P%3BIto%2C+Yoichiro&rft.aulast=Weisz&rft.aufirst=Adrian&rft.date=2011-11-11&rft.volume=1218&rft.issue=45&rft.spage=8249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.09.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Colour; Chromatographic techniques; Solvents; Certification; Nuclear magnetic resonance; Hydroxides; Drugs; Additives; Sulphuric acid; Sulfuric Acid; Mass Spectrometry; Salts; Foods; Chromatography; Analytical Methods; Acids; Color DO - http://dx.doi.org/10.1016/j.chroma.2011.09.049 ER - TY - JOUR T1 - Rapid and simultaneous determination of hexapeptides (Ac-EEMQRR-amide and H sub(2N-EEMQRR-amide) in anti-wrinkle cosmetics by hydrophilic interaction liquid chromatography-solid phase extraction preparation and hydrophilic interaction liquid chromatography with tandem mass spectrometry) AN - 1635020915; 15912103 AB - A rapid method for the simultaneous determination of Ac-EEMQRR-amide and H sub(2N-EEMQRR-amide in cosmetic products was developed and evaluated. This analytical procedure involved extracting samples with 0.1:0.1:85:15 (v:v) trifluoroacetic acid (TFA):formic acid:acetonitrile (ACN):water and determination by hydrophilic interaction liquid chromatography with tandem mass spectrometry (HILIC-MS/MS). Samples showing serious ion suppression were further cleaned up using HILIC-SPE prior to HILIC-MS/MS analysis. Stable isotopically labeled peptides, corresponding to the above two peptides, were used as internal standards to correct for loss of recovery and matrix effects. Electrospray ionization (ESI) in the positive mode was used. The linear range was 2.0-1000 ng/mL for Ac-EEMQRR-amide and 25.0-2500 ng/mL for H) sub(2)N-EEMQRR-amide. Thirteen commercial products were analyzed for the two peptides using this method. The amounts of Ac-EEMQRR-amide in the samples ranged from none detected to 42.3 mu g/g. H sub(2N-EEMQRR-amide was not detected in any of the samples. The recoveries for Ac-EEMQRR-amide and H) sub(2)N-EEMQRR-amide ranged from 85% to 110% and 84% to 119%, respectively, at the spiking level of 30 mu g/g. JF - Journal of Chromatography A AU - Zhou, Wanlong AU - Wang, Perry G AU - Krynitsky, Alexander J AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740-3835, USA, Perry.Wang@fda.hhs.gov Y1 - 2011/11/04/ PY - 2011 DA - 2011 Nov 04 SP - 7956 EP - 7963 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 44 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - Acetyl hexapeptide KW - HILIC KW - ESI KW - MS/MS KW - SPE KW - Stable isotopically labeled peptides KW - Mass Spectrometry KW - Chromatographic techniques KW - Mass spectroscopy KW - Acids KW - Analytical techniques KW - Liquid Chromatography KW - Standards KW - Peptides KW - Ionization KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635020915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Rapid+and+simultaneous+determination+of+hexapeptides+%28Ac-EEMQRR-amide+and+H+sub%282N-EEMQRR-amide%29+in+anti-wrinkle+cosmetics+by+hydrophilic+interaction+liquid+chromatography-solid+phase+extraction+preparation+and+hydrophilic+interaction+liquid+chromatography+with+tandem+mass+spectrometry%29&rft.au=Zhou%2C+Wanlong%3BWang%2C+Perry+G%3BKrynitsky%2C+Alexander+J%3BRader%2C+Jeanne+I&rft.aulast=Zhou&rft.aufirst=Wanlong&rft.date=2011-11-04&rft.volume=1218&rft.issue=44&rft.spage=7956&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2011.08.091 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Analytical techniques; Peptides; Mass spectroscopy; Mass Spectrometry; Acids; Liquid Chromatography; Standards; Ionization DO - http://dx.doi.org/10.1016/j.chroma.2011.08.091 ER - TY - JOUR T1 - Early-Life Exposures and Early-Onset Uterine Leiomyomata in Black Women in the Sister Study AN - 1660045767; 16537011 AB - Background: Uterine leiomyomata (fibroids) are hormonally responsive tumors, but little is known about risk factors. Early-life exposures may influence uterine development and subsequent response to hormones in adulthood. An earlier analysis of non-Hispanic white women who participated in the Sister Study found associations between several early-life factors and early-onset fibroids. Objectives: We evaluated associations of early-life and childhood exposures with early-onset fibroids among black women and compared the results with those found among white women. Methods: We analyzed baseline data from 3,534 black women, 35-59 years of age, in the Sister Study (a nationwide cohort of women who had a sister diagnosed with breast cancer) who self-reported information on early-life and childhood exposures. Early-onset fibroids were assessed based on self-report of a physician diagnosis of fibroids by the age of 30 years (n = 561). We estimated risk ratios (RR) and 95% confidence intervals (CI) from log-binomial regression models. Results: Factors most strongly associated with early-onset fibroids were in utero diethylstilbestrol (DES; RR = 2.02; 95% CI: 1.28, 3.18), maternal prepregnancy diabetes or gestational diabetes (RR = 1.54; 95% CI: 0.95, 2.49), and monozygotic multiple birth (RR = 1.94; 95% CI: 1.26, 2.99). We also found positive associations with having been taller or thinner than peers at the age of 10 years and with early-life factors that included being the firstborn child of a teenage mother, maternal hypertensive disorder, preterm birth, and having been fed soy formula. Conclusions: With the exception of monozygotic multiple birth and maternal hypertensive disorder, early-life risk factors for early-onset fibroids for black women were similar to those found for white women. However, in contrast to whites, childhood height and weight, but not low socioeconomic status indicators, were associated with early-onset fibroids in blacks. The general consistency of early-life findings for black and white women supports a possible role of early-life factors in fibroid development. JF - Environmental Health Perspectives AU - D'Aloisio, Aimee A AU - Baird, Donna D AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2011/11/02/ PY - 2011 DA - 2011 Nov 02 SP - 406 EP - 412 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 120 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - diabetes mellitus KW - diethylstilbestrol KW - early-life KW - leiomyoma KW - multiple birth offspring KW - pregnancy KW - pregnancy-induced hypertension KW - prenatal exposure delayed effects KW - socioeconomic factors KW - soy formula KW - Birth KW - Risk KW - Age KW - Mathematical models KW - Exposure KW - Breast KW - Disorders KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660045767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Early-Life+Exposures+and+Early-Onset+Uterine+Leiomyomata+in+Black+Women+in+the+Sister+Study&rft.au=D%27Aloisio%2C+Aimee+A%3BBaird%2C+Donna+D%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=D%27Aloisio&rft.aufirst=Aimee&rft.date=2011-11-02&rft.volume=120&rft.issue=3&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1103620 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1103620 ER - TY - JOUR T1 - Assessment of Occupational Cosmic Radiation Exposure of Flight Attendants Using Questionnaire Data AN - 968168138; 16120706 AB - Introduction: Female flight attendants may have a higher risk of breast and other cancers than the general population because of routine exposure to cosmic radiation. As part of a forthcoming study of breast and other cancer incidence, occupational cosmic radiation exposure of a cohort of female flight attendants was estimated. Methods: Questionnaire data were collected from living female cohort members who were formerly employed as flight attendants with Pan American World Airways. These data included airline at which the flight attendant was employed, assigned domicile, start and end dates for employment at domicile, and number of block hours and commuter segments flown per month. Questionnaire respondents were assigned daily absorbed and effective doses using a time-weighted dose rate specific to the domicile and/or work history era combined with self-reported work history information. Results: Completed work history questionnaires were received from 5898 living cohort members. Mean employment time as a flight attendant was 7.4 yr at Pan Am and 12 yr in total. Estimated mean annual effective dose from all sources of occupational cosmic radiation exposure was 2.5 plus or minus 1.0 mSv, with a mean career dose of 30 mSv. Discussion: Annual effective doses were similar to doses assessed for other flight attendant cohorts; however, questionnaire-based cumulative doses assessed in this study were on average higher than those assessed for other flight attendant cohorts using company-based records. The difference is attributed to the inclusion of dose from work at other airlines and commuter flights, which was made possible by using questionnaire data. JF - Aviation, Space, and Environmental Medicine AU - Anderson, Jeri L AU - Waters, Martha A AU - Hein, Misty J AU - Schubauer-Berigan, Mary K AU - Pinkerton, Lynne E AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy , MS R-14, Cincinnati, OH 45226, jlanderson@cdc.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1049 EP - 1054 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 82 IS - 11 SN - 0095-6562, 0095-6562 KW - Health & Safety Science Abstracts KW - careers KW - Historical account KW - employment KW - Dose-response effects KW - airlines KW - Cosmic radiation KW - Occupational exposure KW - Cancer KW - crew safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968168138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.atitle=Assessment+of+Occupational+Cosmic+Radiation+Exposure+of+Flight+Attendants+Using+Questionnaire+Data&rft.au=Anderson%2C+Jeri+L%3BWaters%2C+Martha+A%3BHein%2C+Misty+J%3BSchubauer-Berigan%2C+Mary+K%3BPinkerton%2C+Lynne+E&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2011-11-01&rft.volume=82&rft.issue=11&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/10.3357%2FASEM.3091.2011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - careers; Historical account; employment; airlines; Dose-response effects; Cosmic radiation; Cancer; Occupational exposure; crew safety DO - http://dx.doi.org/10.3357/ASEM.3091.2011 ER - TY - JOUR T1 - Understanding and Quantifying Arc Flash Hazards in the Mining Industry AN - 963909176; 16078128 AB - Arc flash generally refers to the dangerous exposure to thermal energy released by an arcing fault on an electrical power system, and in recent years, arc flash hazards have become a prominent safety issue in many industries. This problem, however, has not been effectively addressed in the mining industry. Mine Safety and Health Administration (MSHA) data for the period 1990 through 2001 attribute 836 injuries to "noncontact electric arc burns," making them the most common cause of electrical injury in mining. This paper presents results from several elements of a recent National Institute for Occupational Safety and Health study of arc flash hazards in mining and provides information and recommendations that can help reduce these injuries. The characteristics of past arc flash injuries in mining are first outlined, such as the electrical components and work activities involved (based on MSHA data). This is followed by a review of important concepts and terminology needed to understand this hazard. Next, methods for identifying, measuring, and managing arc flash hazards on a power system are covered, with emphasis on recommendations found in NFPA 70E, Standard for Electrical Safety in the Workplace. Finally, results are presented from a detailed arc flash hazard analysis performed on a sample mine electrical power system using IEEE 1584-2004a, focusing on components and locations presenting severe hazards, as well as engineering solutions for reducing the risk to personnel. JF - IEEE Transactions on Industry Applications AU - Homce, Gerald T AU - Cawley, James C AD - U.S. Department of Health and Human Services, Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, PA, USA Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 2437 EP - 2444 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 47 IS - 6 SN - 0093-9994, 0093-9994 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Burns KW - Electric power KW - safety engineering KW - Safety regulations KW - Injuries KW - Safety engineering KW - Reviews KW - Occupational safety KW - Mining KW - Risk reduction KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/963909176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Industry+Applications&rft.atitle=Understanding+and+Quantifying+Arc+Flash+Hazards+in+the+Mining+Industry&rft.au=Homce%2C+Gerald+T%3BCawley%2C+James+C&rft.aulast=Homce&rft.aufirst=Gerald&rft.date=2011-11-01&rft.volume=47&rft.issue=6&rft.spage=2437&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Industry+Applications&rft.issn=00939994&rft_id=info:doi/10.1109%2FTIA.2011.2169170 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Burns; Electric power; Safety regulations; safety engineering; Safety engineering; Injuries; Reviews; Occupational safety; Risk reduction; Mining DO - http://dx.doi.org/10.1109/TIA.2011.2169170 ER - TY - JOUR T1 - Serum total and HDL cholesterol and risk of prostate cancer AN - 926884750; 16351686 AB - Background: Studies suggest a decreased risk of high-grade prostate cancer in men with lower circulating total cholesterol and that statins may protect against aggressive disease. Confirmation in additional populations and examination of associations for lipoprotein subfractions are needed. Methods: We examined prostate cancer risk and serum total and HDL cholesterol in the ATBC Study cohort (n = 29,093). Cox proportional hazards models were used to estimate the relative risk of total (n = 2,041), non-aggressive (n = 829), aggressive (n = 461), advanced (n = 412), and high-grade (n = 231) prostate cancer by categories of total and HDL cholesterol. Results: After excluding the first 10 years of follow-up, men with higher serum total cholesterol were at increased risk of overall ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03-1.44, p-trend = 0 .01) and advanced ( greater than or equal to 240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13-3.03, p-trend = 0 .05) prostate cancer. Higher HDL cholesterol was suggestively associated with a decreased risk of prostate cancer regardless of stage or grade. Conclusions: In this population of smokers, high serum total cholesterol was associated with higher risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced the risk of prostate cancer overall. These results support previous studies and, indirectly, support the hypothesis that statins may reduce the risk of advanced prostate cancer by lowering cholesterol. JF - Cancer Causes & Control AU - Mondul, Alison M AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Department of Health and Human Services, Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd. Ste. 320, Rockville, MD, 20852, USA, mondulam@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1545 EP - 1552 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 22 IS - 11 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Cholesterol KW - Prostate cancer KW - Risk reduction KW - Statins KW - cholesterol KW - prostate cancer KW - risk reduction KW - statins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926884750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Serum+total+and+HDL+cholesterol+and+risk+of+prostate+cancer&rft.au=Mondul%2C+Alison+M%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Mondul&rft.aufirst=Alison&rft.date=2011-11-01&rft.volume=22&rft.issue=11&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-011-9831-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - risk reduction; Statins; Prostate cancer; statins; Risk reduction; Cholesterol; prostate cancer; cholesterol; Cancer DO - http://dx.doi.org/10.1007/s10552-011-9831-7 ER - TY - JOUR T1 - In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos AN - 911168007; 16084777 AB - We describe an imaging procedure to measure axon length in zebrafish embryos in vivo. Automated fluorescent image acquisition was performed with the ImageXpress Micro high content screening reader and further analysis of axon lengths was performed on archived images using AcuityXpress software. We utilized the Neurite Outgrowth Application module with a customized protocol (journal) to measure the axons. Since higher doses of ethanol (2-2.5%, v/v) have been shown to deform motor neurons and axons during development, here we used ethanol to treat transgenic [hb9:GFP (green fluorescent protein)] zebrafish embryos at 28 hpf (hours post-fertilization). These embryos express GFP in the motor neurons and their axons. Embryos after ethanol treatment were arrayed in 384-well plates for automated fluorescent image acquisition in vivo. Average axon lengths of high dose ethanol-treated embryos were significantly lower than the control. Another experiment showed that there was no significant difference in the axon lengths between the embryos grown for 24h at 22 degree C and 28.5 degree C. These test experiments demonstrate that using axon development as an end-point, compound screening can be performed in a time-efficient manner. JF - Neurotoxicology and Teratology AU - Kanungo, Jyotshnabala AU - Lantz, Susan AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, United States, jyotshnabala.kanungo@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 618 EP - 623 PB - Elsevier B.V., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 33 IS - 6 SN - 0892-0362, 0892-0362 KW - ASFA 1: Biological Sciences & Living Resources; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Zebrafish KW - Transgenic embryo KW - Axon KW - High content imaging KW - Ethanol KW - Screening KW - Green fluorescent protein KW - Embryonic development KW - Development KW - Freshwater KW - Freshwater fish KW - Imaging techniques KW - Danio rerio KW - Motor neurons KW - Computer programs KW - software KW - Neurons KW - Teratology KW - Axonogenesis KW - Axons KW - Embryos KW - Archives KW - N3 11028:Neuropharmacology & toxicology KW - Q1 08344:Reproduction and development KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911168007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=In+vivo+imaging+and+quantitative+analysis+of+changes+in+axon+length+using+transgenic+zebrafish+embryos&rft.au=Kanungo%2C+Jyotshnabala%3BLantz%2C+Susan%3BPaule%2C+Merle+G&rft.aulast=Kanungo&rft.aufirst=Jyotshnabala&rft.date=2011-11-01&rft.volume=33&rft.issue=6&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2011.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Screening; Neurons; Teratology; Embryonic development; Embryos; Archives; Freshwater fish; Imaging techniques; Computer programs; Motor neurons; software; Green fluorescent protein; Axonogenesis; Axons; Development; Ethanol; Danio rerio; Freshwater DO - http://dx.doi.org/10.1016/j.ntt.2011.08.013 ER - TY - JOUR T1 - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone in the National Health and Nutrition Examination Survey 1999-2002 AN - 911155124; 15965247 AB - The relationships between blood lead levels and serum follicle stimulating hormone and luteinizing hormone were assessed in a nationally representative sample of women, 35-60 years old, from the National Health and Nutrition Examination Survey 1999-2002. The blood lead levels of the women ranged from 0.2 to 17.0 mu g/dL. The estimated geometric mean was 1.4 mu g/dL, and the estimated arithmetic mean was 1.6 mu g/dL. As the blood lead level increased, the concentration of serum follicle stimulating hormone increased in post-menopausal women, women who had both ovaries removed, and pre-menopausal women. The concentration of luteinizing hormone increased as blood lead level increased in post-menopausal women and women who had both ovaries removed. The lowest concentrations of blood lead at which a relationship was detected were 0.9 mu g/dL for follicle stimulating hormone and 3.2 mu g/dL for luteinizing hormone. Lead may act directly or indirectly at ovarian and non-ovarian sites to increase the concentrations of follicle stimulating hormone and luteinizing hormone. JF - Reproductive Toxicology AU - Krieg, Edward F AU - Feng, Huiling A AD - National Institute for Occupational Safety and Health, Robert A. Taft Laboratories, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226, United States, erk3@cdc.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 277 EP - 285 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 32 IS - 3 SN - 0890-6238, 0890-6238 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Follicles KW - Hormones KW - Nutrition KW - Lead KW - Blood levels KW - Mathematics KW - Blood KW - Luteinizing hormone KW - Ovaries KW - H 12000:Epidemiology and Public Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=The+relationships+between+blood+lead+levels+and+serum+follicle+stimulating+hormone+and+luteinizing+hormone+in+the+National+Health+and+Nutrition+Examination+Survey+1999-2002&rft.au=Krieg%2C+Edward+F%3BFeng%2C+Huiling+A&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2011-11-01&rft.volume=32&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2011.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - Blood; Follicles; Luteinizing hormone; Ovaries; Nutrition; Hormones; Lead; Mathematics; Blood levels DO - http://dx.doi.org/10.1016/j.reprotox.2011.05.012 ER - TY - JOUR T1 - The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats. AN - 904223451; 21373894 AB - The iron chelator Dp44mT is a potent topoisomerase IIα inhibitor with novel anticancer activity. Doxorubicin (Dox), the current front-line therapy for breast cancer, induces a dose-limiting cardiotoxicity, in part through an iron-mediated pathway. We tested the hypothesis that Dp44mT can improve clinical outcomes of treatment with Dox by alleviating cardiotoxicity. The general cardiac and renal toxicities induced by Dox were investigated in the presence and absence of Dp44mT. The iron chelating cardioprotectant Dexrazoxane (Drz), which is approved for this indication, was used as a positive control. In vitro studies were carried out with H9c2 rat cardiomyocytes and in vivo studies were performed using spontaneously hypertensive rats. Testing of the GI(50) profile of Dp44mT in the NCI-60 panel confirmed activity against breast cancer cells. An acute, toxic dose of Dox caused the predicted cellular and cardiac toxicities, such as cell death and DNA damage in vitro and elevated cardiac troponin T levels, tissue damage, and apoptosis in vivo. Dp44mT alone caused insignificant changes in hematological and biochemical indices in rats, indicating that Dp44mT is not significantly cardiotoxic as a single agent. In contrast to Drz, Dp44mT failed to mitigate Dox-induced cardiotoxicity in vivo. We conclude that although Dp44mT is a potent iron chelator, it is unlikely to be an appropriate cardioprotectant against Dox-induced toxicity. However, it should continue to be evaluated as a potential anticancer agent as it has a novel mechanism for inhibiting the growth of a broad range of malignant cell types while exhibiting very low intrinsic toxicity to healthy tissues. JF - Cancer chemotherapy and pharmacology AU - Rao, V Ashutosh AU - Zhang, Jun AU - Klein, Sarah R AU - Espandiari, Parvaneh AU - Knapton, Alan AU - Dickey, Jennifer S AU - Herman, Eugene AU - Shacter, Emily B AD - Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Building 29A, Room 2A-11, Bethesda, MD 20892, USA. ashutosh.rao@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1125 EP - 1134 VL - 68 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Iron Chelating Agents KW - Thiosemicarbazones KW - Troponin T KW - di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred SHR KW - Troponin T -- metabolism KW - Humans KW - Apoptosis -- drug effects KW - Cell Line, Tumor KW - Immunohistochemistry KW - Male KW - Cell Proliferation -- drug effects KW - Antineoplastic Agents -- toxicity KW - Heart -- drug effects KW - Doxorubicin -- toxicity KW - Thiosemicarbazones -- pharmacology KW - Iron Chelating Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904223451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=The+iron+chelator+Dp44mT+inhibits+the+proliferation+of+cancer+cells+but+fails+to+protect+from+doxorubicin-induced+cardiotoxicity+in+spontaneously+hypertensive+rats.&rft.au=Rao%2C+V+Ashutosh%3BZhang%2C+Jun%3BKlein%2C+Sarah+R%3BEspandiari%2C+Parvaneh%3BKnapton%2C+Alan%3BDickey%2C+Jennifer+S%3BHerman%2C+Eugene%3BShacter%2C+Emily+B&rft.aulast=Rao&rft.aufirst=V&rft.date=2011-11-01&rft.volume=68&rft.issue=5&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-011-1587-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-27 N1 - Date created - 2011-11-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-011-1587-y ER - TY - JOUR T1 - Signal detection of methylphenidate by comparing a spontaneous reporting database with a claims database. AN - 903663261; 21510997 AB - Data mining is critical for signal detection in pharmacovigilance systems. In this study, we compared signals between spontaneous reporting data and health insurance claims data for a socially issued drug, methylphenidate. We implemented data-mining tools for signal detection in both databases: Reporting Odds Ratios (ROR), Proportional Reporting Ratios (PRR), Chi-squared test, and Information Component (IC), in addition to a Relative Risk (RR) tool in the claims database. The claims database generated 15, 15, 36, 1, and 1 adverse drug reactions (ADRs) by ROR, PRR, chi-square, IC, and RR, respectively. The World Health Organization (WHO) spontaneous database generated 91, 91, 137, and 96 ADRs by ROR, PRR, chi-square, and IC, respectively. We found seven potential matching associations from the claims and WHO databases, but only one of them was present in the Korean spontaneous reporting database. In Korea, spontaneous reporting is still underreported and there is a small amount of data for Koreans. Signal comparison between the claims and WHO databases can provide additional regulatory insight. Copyright © 2011. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Kim, JaYoung AU - Kim, Munsin AU - Ha, Ji-Hye AU - Jang, Junghoon AU - Hwang, Myungsil AU - Lee, Byung Koo AU - Chung, Myeon Woo AU - Yoo, Tae Moo AU - Kim, Myung Jung AD - Pharmaceutical Safety Bureau, Korea Food and Drug Administration, Osong 363-951, Republic of Korea. Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 154 EP - 160 VL - 61 IS - 2 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Risk KW - Republic of Korea KW - Pharmacovigilance KW - Odds Ratio KW - Signal Detection, Psychological KW - Drug-Related Side Effects and Adverse Reactions -- chemically induced KW - Humans KW - Data Mining -- methods KW - Research Report KW - Insurance Claim Reporting KW - Adverse Drug Reaction Reporting Systems KW - Methylphenidate -- adverse effects KW - Databases, Factual UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/903663261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Signal+detection+of+methylphenidate+by+comparing+a+spontaneous+reporting+database+with+a+claims+database.&rft.au=Kim%2C+JaYoung%3BKim%2C+Munsin%3BHa%2C+Ji-Hye%3BJang%2C+Junghoon%3BHwang%2C+Myungsil%3BLee%2C+Byung+Koo%3BChung%2C+Myeon+Woo%3BYoo%2C+Tae+Moo%3BKim%2C+Myung+Jung&rft.aulast=Kim&rft.aufirst=JaYoung&rft.date=2011-11-01&rft.volume=61&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-16 N1 - Date created - 2011-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.03.015 ER - TY - JOUR T1 - Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose AN - 902378726; 15839077 AB - The lichen metabolite usnic acid (UA) has been promoted as a dietary supplement for weight loss, although cases of hepatotoxicity have been reported. Here we evaluated UA-associated hepatotoxicity in vitro using isolated rat hepatocytes. We measured cell viability and ATP content to evaluate UA induced cytotoxicity and applied 13C isotopomer distribution measuring techniques to gain a better understanding of glucose metabolism during cytotoxicity. The cells were exposed to 0, 1, 5 or 10 mu M UA concentrations for 2, 6 or 24h. Aliquots of media were collected at the end of these time periods and the 13C mass isotopomer distribution determined for CO2, lactate, glucose and glutamate. The 1 mu M UA exposure did not appear to cause significant change in cell viability compared to controls. However, the 5 and 10 mu M UA concentrations significantly reduced cell viability as exposure time increased. Similar results were obtained for ATP depletion experiments. The 1 and 5 mu M UA doses suggest increased oxidative phosphorylation. Conversely, oxidative phosphorylation and gluconeogenesis were dramatically inhibited by 10 mu M UA. Augmented oxidative phosphorylation at the lower UA concentrations may be an adaptive response by the cells to compensate for diminished mitochondrial function. JF - Food and Chemical Toxicology AU - Sonko, Bakary J AU - Schmitt, Thomas C AU - Guo, Lei AU - Shi, Qiang AU - Boros, Laszlo G AU - Leakey, Julian EA AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA, Richard.Beger@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 2968 EP - 2974 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 49 IS - 11 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Usnic acid KW - Hepatotoxicity KW - U-13C6-d-glucose KW - Mass isotopomer distribution analysis (MIDA) KW - Hepatocytes KW - Oxidative phosphorylation KW - Measuring techniques KW - Mitochondria KW - ATP KW - Metabolites KW - Glucose metabolism KW - Toxicity KW - hepatotoxicity KW - Body weight loss KW - Cytotoxicity KW - Lichens KW - Dietary supplements KW - Gluconeogenesis KW - Lactic acid KW - Glutamic acid KW - Carbon dioxide KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902378726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Assessment+of+usnic+acid+toxicity+in+rat+primary+hepatocytes+using+13C+isotopomer+distribution+analysis+of+lactate%2C+glutamate+and+glucose&rft.au=Sonko%2C+Bakary+J%3BSchmitt%2C+Thomas+C%3BGuo%2C+Lei%3BShi%2C+Qiang%3BBoros%2C+Laszlo+G%3BLeakey%2C+Julian+EA%3BBeger%2C+Richard+D&rft.aulast=Sonko&rft.aufirst=Bakary&rft.date=2011-11-01&rft.volume=49&rft.issue=11&rft.spage=2968&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2011.07.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Oxidative phosphorylation; Hepatocytes; Measuring techniques; ATP; Mitochondria; Metabolites; Toxicity; Glucose metabolism; hepatotoxicity; Body weight loss; Cytotoxicity; Lichens; Dietary supplements; Gluconeogenesis; Lactic acid; Usnic acid; Glutamic acid; Carbon dioxide DO - http://dx.doi.org/10.1016/j.fct.2011.07.047 ER - TY - JOUR T1 - Monte Carlo modeling of time-resolved fluorescence for depth-selective interrogation of layered tissue AN - 902367047; 15910522 AB - Computational approaches for simulation of light-tissue interactions have provided extensive insight into biophotonic procedures for diagnosis and therapy. However, few studies have addressed simulation of time-resolved fluorescence (TRF) in tissue and none have combined Monte Carlo simulations with standard TRF processing algorithms to elucidate approaches for cancer detection in layered biological tissue. In this study, we investigate how illumination-collection parameters (e.g., collection angle and source-detector separation) influence the ability to measure fluorophore lifetime and tissue layer thickness. Decay curves are simulated with a Monte Carlo TRF light propagation model. Multi-exponential iterative deconvolution is used to determine lifetimes and fractional signal contributions. The ability to detect changes in mucosal thickness is optimized by probes that selectively interrogate regions superficial to the mucosal-submucosal boundary. Optimal accuracy in simultaneous determination of lifetimes in both layers is achieved when each layer contributes 40-60% of the signal. These results indicate that depth-selective approaches to TRF have the potential to enhance disease detection in layered biological tissue and that modeling can play an important role in probe design optimization. JF - Computer Methods and Programs in Biomedicine AU - Pfefer, TJoshua AU - Wang, Quanzeng AU - Drezek, Rebekah A AD - Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, United States, joshua.pfefer@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 161 EP - 167 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 104 IS - 2 SN - 0169-2607, 0169-2607 KW - Biotechnology and Bioengineering Abstracts KW - Monte Carlo KW - Light-tissue interaction KW - Optical diagnostics KW - Cancer detection KW - Monte Carlo simulation KW - Fluorescence KW - Mucosa KW - Probes KW - Boundaries KW - Algorithms KW - fluorophores KW - Computer applications KW - Cancer KW - Light effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902367047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Monte+Carlo+modeling+of+time-resolved+fluorescence+for+depth-selective+interrogation+of+layered+tissue&rft.au=Pfefer%2C+TJoshua%3BWang%2C+Quanzeng%3BDrezek%2C+Rebekah+A&rft.aulast=Pfefer&rft.aufirst=TJoshua&rft.date=2011-11-01&rft.volume=104&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2010.10.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Fluorescence; Mucosa; Algorithms; Boundaries; Probes; fluorophores; Computer applications; Cancer; Light effects DO - http://dx.doi.org/10.1016/j.cmpb.2010.10.011 ER - TY - JOUR T1 - Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer-derived stromal cells. AN - 901306109; 21914638 AB - Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone (DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) isoflavones inhibits transforming growth factor (TGF)-β-induced androgenicity. Mechanisms controlling those activities were explored. Three hydroxysteroid dehydrogenases (HSDs), 3β-HSD, HSD-17β1 and HSD-17β5 involved in metabolizing DHEA to testosterone (TESTO) were investigated. Individual depletion of HSDs in 6S cells significantly reduced TGF-β1/DHEA-induced PSA in LAPC-4 cells in cocultures. Monomer amounts of 3β-HSD were similar without or with TGF-β1 in both cell types but aggregates of 3β-HSD in 6S cells were much higher than those in LAPC-4 cells and were upregulated by TGFβ in 6S cells. Basal and TGF-β1-treated levels of HSD-17β1 and HSD-17β5 in LAPC-4 cells were significantly lower than in 6S cells, whereas levels of HSD-17β1 but not HSD-17β5 were TGFβ inducible. 6S cell HSD genes expression induced by TGFβ or androgen signaling was insignificant to contribute TGF-β1/DHEA-upregulated protein levels of HSDs. RC decreased TGF-β1- upregulation of aggregates of 3β-HSD but not HSD-17β1. Depletion of TGFβ receptors (TGFβ Rs) reduced TGF-β1/DHEA-upregulated HSDs and TESTO. Immunoprecipitation studies demonstrated that TGF-β1 disrupted associations of TGFβ Rs/HSDs aggregates, whereas RC suppressed the dissociations of aggregates of 3β-HSD but not HSD-17β1 from the receptors. Given that TGFβ Rs are recycled with or without ligand, TGF-β1-induced disassociation of the HSDs from TGFβ Rs may increase stability and activity of the HSDs. These data suggest a pathway connecting overproduction of TGFβ with increased PSA in prostate cancer. JF - Carcinogenesis AU - Liu, Xunxian AU - Piao, Yun-Shang AU - Arnold, Julia T AD - Endocrine Section, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. xunxianl@mail.nih.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 1648 EP - 1654 VL - 32 IS - 11 KW - Isoflavones KW - 0 KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta1 KW - Testosterone KW - 3XMK78S47O KW - 3-Hydroxysteroid Dehydrogenases KW - EC 1.1.- KW - Hydroxysteroid Dehydrogenases KW - AKR1C3 protein, human KW - EC 1.1.1.- KW - Hydroxyprostaglandin Dehydrogenases KW - Estradiol Dehydrogenases KW - EC 1.1.1.62 KW - HSD17B1 protein, human KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Prostatic Neoplasms -- metabolism KW - Estradiol Dehydrogenases -- antagonists & inhibitors KW - Receptors, Transforming Growth Factor beta -- genetics KW - Prostate -- drug effects KW - Immunoblotting KW - 3-Hydroxysteroid Dehydrogenases -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- genetics KW - Humans KW - Receptors, Transforming Growth Factor beta -- metabolism KW - Prostate -- metabolism KW - Immunoprecipitation KW - Hydroxyprostaglandin Dehydrogenases -- antagonists & inhibitors KW - Prostatic Neoplasms -- drug therapy KW - Hydroxyprostaglandin Dehydrogenases -- metabolism KW - Prostatic Neoplasms -- pathology KW - Estradiol Dehydrogenases -- genetics KW - Estradiol Dehydrogenases -- metabolism KW - Hydroxyprostaglandin Dehydrogenases -- genetics KW - Cells, Cultured KW - Prostate-Specific Antigen -- metabolism KW - 3-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Male KW - Testosterone -- metabolism KW - Stromal Cells -- drug effects KW - Isoflavones -- pharmacology KW - Hydroxysteroid Dehydrogenases -- metabolism KW - Hydroxysteroid Dehydrogenases -- genetics KW - Transforming Growth Factor beta1 -- pharmacology KW - Stromal Cells -- metabolism KW - Hydroxysteroid Dehydrogenases -- antagonists & inhibitors KW - Trifolium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/901306109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+%CE%B21+increase+of+hydroxysteroid+dehydrogenase+proteins+is+partly+suppressed+by+red+clover+isoflavones+in+human+primary+prostate+cancer-derived+stromal+cells.&rft.au=Liu%2C+Xunxian%3BPiao%2C+Yun-Shang%3BArnold%2C+Julia+T&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2011-11-01&rft.volume=32&rft.issue=11&rft.spage=1648&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgr206 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-22 N1 - Date created - 2011-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prostate. 2000 Oct 1;45(2):140-8 [11027413] Prostate. 2011 May 15;71(7):766-77 [21031436] Nat Rev Mol Cell Biol. 2000 Dec;1(3):169-78 [11252892] J Urol. 2001 Dec;166(6):2472-83 [11696814] Clin Cancer Res. 2002 Sep;8(9):2912-23 [12231536] Mol Biol Cell. 2004 Sep;15(9):4166-78 [15229286] N Engl J Med. 1986 Dec 25;315(26):1650-9 [3537791] Ann N Y Acad Sci. 1994 May 31;719:553-63 [8010623] Steroids. 1996 Jan;61(1):41-6 [8789735] Exp Cell Res. 1997 May 1;232(2):208-15 [9168795] Prostate. 1999 Jun 1;39(4):285-90 [10344218] Mech Ageing Dev. 2005 Jan;126(1):59-69 [15610763] Curr Biol. 2005 Nov 22;15(22):1989-97 [16303557] Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60 [16368782] Nat Rev Cancer. 2006 Jul;6(7):506-20 [16794634] Endocrinology. 2006 Dec;147(12):5806-16 [16959841] Clin Dermatol. 2007 Jan-Feb;25(1):56-62 [17276202] Carcinogenesis. 2008 Apr;29(4):816-23 [18283040] Best Pract Res Clin Endocrinol Metab. 2008 Apr;22(2):207-21 [18471780] J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):240-6 [18621129] ChemMedChem. 2008 Sep;3(9):1371-6 [18576452] Cancer Prev Res (Phila). 2009 Feb;2(2):134-42 [19141600] Mol Cell Endocrinol. 2009 Mar 25;301(1-2):83-8 [19013497] Clin Cancer Res. 2009 Aug 1;15(15):4815-22 [19638459] Endocr Relat Cancer. 2009 Dec;16(4):1139-55 [19608712] Trends Immunol. 2010 Jun;31(6):220-7 [20538542] J Mol Endocrinol. 2001 Feb;26(1):11-9 [11174850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgr206 ER - TY - JOUR T1 - Developmental treatment with bisphenol A or ethinyl estradiol causes few alterations on early preweaning measures. AN - 900627109; 21813462 AB - Because bisphenol A (BPA) exposure is nearly ubiquitous, increased knowledge of its potential effects on development will enable better risk assessment and regulatory guidance. Here, Sprague-Dawley rats were reared in low exogenous estrogen environments. After breeding at adulthood, dams were gavaged on gestational days (GDs) 6-21 with vehicle (VEH), 2.5 or 25.0 μg/kg/day BPA, or 5.0 or 10.0 μg/kg/day ethinyl estradiol (EE₂). Offspring were orally treated on postnatal days (PNDs) 1-21 with the same dose the dam received. Relative to the VEH group, dams of both EE₂-treated groups weighed less throughout gestation and lactation. PND 1 absolute anogenital distance and anogenital index were unaltered by any treatment. Ages at fur development and eye and ear opening were unaffected by any treatment. Despite a significant treatment effect, no group was significantly different from VEH in PNDs 3-6 righting latencies; although males had shorter latencies and all latencies decreased with age. PNDs 8-11 slant board behavior was unaffected by any treatment; however, males had shorter turning latencies and latencies decreased with age. Preweaning body weights of BPA- and EE₂-treated groups as well as naive controls were less than VEH. No treatment affected PND 21 whole or regional brain weights or levels of estradiol, testosterone, corticosterone, T3, T4, luteinizing hormone, ghrelin, or leptin. These results add to the literature indicating that developmental BPA treatment at these doses has no effects on gestational or lactational body weight, offspring anogenital distance, preweaning behaviors or hormone levels, and whole and regional brain weights measured at weaning. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ferguson, Sherry A AU - Law, Charles D AU - Abshire, Jordan S AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA. Sherry.Ferguson@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 149 EP - 160 VL - 124 IS - 1 KW - Benzhydryl Compounds KW - 0 KW - Hormones KW - Phenols KW - Ethinyl Estradiol KW - 423D2T571U KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Genitalia -- growth & development KW - Gestational Age KW - Hormones -- blood KW - Weaning KW - Pregnancy KW - Reflex, Righting -- drug effects KW - Rats KW - Genitalia -- drug effects KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - Body Weight -- drug effects KW - Male KW - Brain -- growth & development KW - Female KW - Proportional Hazards Models KW - Organ Size -- drug effects KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Phenols -- toxicity KW - Ethinyl Estradiol -- toxicity KW - Prenatal Exposure Delayed Effects -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/900627109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Developmental+treatment+with+bisphenol+A+or+ethinyl+estradiol+causes+few+alterations+on+early+preweaning+measures.&rft.au=Ferguson%2C+Sherry+A%3BLaw%2C+Charles+D%3BAbshire%2C+Jordan+S&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2011-11-01&rft.volume=124&rft.issue=1&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr201 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-12 N1 - Date created - 2011-10-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Sci. 2013 Aug;134(2):428 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr201 ER - TY - JOUR T1 - Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. AN - 898839076; 21876048 AB - The veterinary cephalosporin drug ceftiofur is rapidly degraded in the bovine intestinal tract. A cylinder-plate assay was used to detect microbiologically active ceftiofur, and high-performance liquid chromatography-mass spectrometry analysis was used to quantify the amount of ceftiofur remaining after incubation with bovine intestinal anaerobic bacteria, which were isolated from colon contents or feces from 8 cattle. Ninety-six percent of the isolates were able to inactivate ceftiofur to some degree, and 54% actually degraded the drug. None of 9 fungal isolates inactivated or degraded ceftiofur. Facultative and obligate anaerobic bacterial species that inactivated or degraded ceftiofur were identified with Vitek and Biolog systems, respectively. A subset of ceftiofur degraders also degraded the chemically similar drug ceftriaxone. Most of the species of bacteria that degraded ceftiofur belonged to the genera Bacillus and Bacteroides. PCR analysis of bacterial DNA detected specific β-lactamase genes. Bacillus cereus and B. mycoides isolates produced extended-spectrum β-lactamases and metallo-β-lactamases. Seven isolates of Bacteroides spp. produced multiple β-lactamases, including possibly CepA, and metallo-β-lactamases. Isolates of Eubacterium biforme, Bifidobacterium breve, and several Clostridium spp. also produced ceftiofur-degrading β-lactamases. An agar gel overlay technique on isoelectric focusing separations of bacterial lysates showed that β-lactamase enzymes were sufficient to degrade ceftiofur. These results suggest that ceftiofur is inactivated nonenzymatically and degraded enzymatically by multiple β-lactamases from bacteria in the large intestines of cattle. JF - Antimicrobial agents and chemotherapy AU - Wagner, R Doug AU - Johnson, Shemedia J AU - Cerniglia, Carl E AU - Erickson, Bruce D AD - Microbiology Division, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. doug.wagner@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 4990 EP - 4998 VL - 55 IS - 11 KW - Cephalosporins KW - 0 KW - Ceftriaxone KW - 75J73V1629 KW - ceftiofur KW - 83JL932I1C KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Mass Spectrometry KW - Animals KW - Bacteroides -- metabolism KW - Eubacterium -- enzymology KW - Bacteroides -- enzymology KW - Bacillus cereus -- enzymology KW - Chromatography, High Pressure Liquid KW - Polymerase Chain Reaction KW - Clostridium -- metabolism KW - Cattle KW - Eubacterium -- metabolism KW - Bacillus cereus -- metabolism KW - Bifidobacterium -- enzymology KW - Bifidobacterium -- metabolism KW - Clostridium -- enzymology KW - Ceftriaxone -- metabolism KW - Cephalosporins -- metabolism KW - beta-Lactamases -- metabolism KW - Intestines -- microbiology KW - beta-Lactamases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/898839076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Bovine+intestinal+bacteria+inactivate+and+degrade+ceftiofur+and+ceftriaxone+with+multiple+beta-lactamases.&rft.au=Wagner%2C+R+Doug%3BJohnson%2C+Shemedia+J%3BCerniglia%2C+Carl+E%3BErickson%2C+Bruce+D&rft.aulast=Wagner&rft.aufirst=R&rft.date=2011-11-01&rft.volume=55&rft.issue=11&rft.spage=4990&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00008-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-10 N1 - Date created - 2011-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2000 Dec 27;284(24):3151-6 [11135779] J Comput Biol. 2000 Feb-Apr;7(1-2):203-14 [10890397] Antimicrob Agents Chemother. 2002 Jan;46(1):1-11 [11751104] Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):996-1001 [11792842] Appl Environ Microbiol. 2002 Apr;68(4):1786-93 [11916697] Curr Top Med Chem. 2002 Jul;2(7):717-31 [12052187] Antimicrob Agents Chemother. 2002 Oct;46(10):3215-22 [12234847] Environ Res. 2003 Sep;93(1):45-51 [12865047] J Gen Microbiol. 1975 May;88(1):169-78 [807678] J Bacteriol. 1987 Feb;169(2):579-86 [3027036] Biochem J. 1987 Dec 15;248(3):657-62 [3124817] J Bacteriol. 1990 May;172(5):2584-93 [2110145] J Dairy Sci. 1992 Jul;75(7):1870-6 [1500583] Antimicrob Agents Chemother. 1992 Sep;36(9):1981-6 [1329636] Infection. 1993 Mar-Apr;21(2):127-30 [8491523] Antimicrob Agents Chemother. 1993 May;37(5):1028-36 [8517690] Antimicrob Agents Chemother. 1994 May;38(5):991-6 [8067782] Antimicrob Agents Chemother. 1994 Aug;38(8):1711-5 [7985999] J Chromatogr B Biomed Appl. 1995 Nov 17;673(2):231-44 [8611957] J Vet Diagn Invest. 1996 Jan;8(1):121-3 [9026069] J Pharm Sci. 1997 Mar;86(3):389-95 [9050811] J Vet Pharmacol Ther. 1998 Apr;21(2):112-20 [9597648] Mayo Clin Proc. 1999 Feb;74(2):187-95 [10069359] Antimicrob Agents Chemother. 2005 Oct;49(10):4061-7 [16189081] Appl Environ Microbiol. 2006 Jun;72(6):3940-8 [16751500] Am J Vet Res. 2006 Oct;67(10):1696-700 [17014318] Curr Microbiol. 2006 Nov;53(5):440-3 [17019644] J Clin Microbiol. 2007 Feb;45(2):544-7 [17093019] FEMS Microbiol Lett. 2008 Feb;279(2):162-6 [18093137] BMC Genomics. 2008;9:247 [18505588] BMC Microbiol. 2008;8:125 [18652685] Appl Environ Microbiol. 2008 Nov;74(22):6956-62 [18820057] Appl Environ Microbiol. 2009 Jun;75(11):3648-55 [19376926] Vet Microbiol. 2009 Oct 20;139(1-2):89-96 [19428193] Foodborne Pathog Dis. 2009 Oct;6(8):917-24 [19622032] Antimicrob Agents Chemother. 2010 Mar;54(3):969-76 [19995920] N Engl J Med. 2000 Apr 27;342(17):1242-9 [10781620] Clin Pharmacokinet. 2001;40(9):685-94 [11605716] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AAC.00008-11 ER - TY - JOUR T1 - Pelvic/Retroperitoneal Salvage Lymph Node Dissection for Patients Treated With Radical Prostatectomy With Biochemical Recurrence and Nodal Recurrence Detected by [11C]Choline Positron Emission Tomography/Computed Tomography AN - 1238122552; 15796492 AB - Background: The management of patients with clinical recurrence of prostate cancer after radical prostatectomy (RP) remains challenging. Objective: To determine whether the removal of positive lymph nodes at [11C]choline positron emission tomography/computed tomography (PET/CT) scan may have an impact on the prognosis of patients with biochemical recurrence (BCR) and nodal recurrence after RP. Design, setting, and participants: Prospective analysis of 72 patients affected by BCR after RP associated with a nodal pathologic [11C]choline PET/CT scan. Intervention: Patients underwent salvage lymph node dissection (LND). Measurements: Biochemical response (BR) to treatment was defined as prostate-specific antigen (PSA) 0.2 ng/ml at 40 d after salvage LND. Kaplan-Meier and Cox regression analyses addressed time to and predictors of clinical recurrence (CR) after salvage LND, respectively. Results and limitations: Overall, 56.9% of patients achieved BR. Mean and median follow-up after LND were 39.4 and 39.8 mo, respectively. The 5-yr BCR-free survival rate was 19%. Preoperative PSA 4 ng/ml (hazard ratio [HR]: 0.12; p = 0.005), time to BCR 24 mo (HR: 7.52; p = 0.005), and negative lymph nodes at previous RP (HR: 0.19; p = 0.04) represented independent predictors of BR. Overall, 5-yr CR-free and cancer-specific survival were 34% and 75%, respectively. At multivariable analyses, only PSA 4 ng/ml (HR: 2.13; p = 0.03) and the presence of retroperitoneal uptake at PET/CT scan (HR = 2.92; p = 0.004) represented independent preoperative predictors of CR. Similarly, the presence of pathologic nodes in the retroperitoneum (HR: 2.78; p = 0.02), higher number of positive lymph nodes (HR: 1.04; p = 0.006), and complete BR to salvage LND (HR: 0.31; p = 0.002) represented postoperative independent predictors of CR. Main limitations consisted of the lack of a control group and the heterogeneity of patients included in the analyses. Conclusions: Salvage LND is feasible in patients with BCR after RP and nodal pathologic uptake at [11C]choline PET/CT scan. Biochemical response after surgery can be achieved in a consistent proportion of patients. Although most patients invariably progressed to BCR after surgery at longer follow-up, 35% of patients showed the absence of CR at 5 yr. JF - European Urology AU - Rigatti, Patrizio AU - Suardi, Nazareno AU - Briganti, Alberto AU - Pozzo, Luigi FDa AU - Tutolo, Manuela AU - Villa, Luca AU - Gallina, Andrea AU - Capitanio, Umberto AU - Abdollah, Firas AU - Scattoni, Vincenzo AU - Colombo, Renzo AU - Freschi, Massimo AU - Picchio, Maria AU - Messa, Cristina AU - Guazzoni, Giorgio AU - Montorsi, Francesco AD - Department of Urology, Urological Research Institute, University Vita-Salute San Raffaele, Milan, Italy, suardi.nazareno@hsr.it Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 935 EP - 943 PB - S. Karger AG, P.O. Box Basel CH-4009 Switzerland VL - 60 IS - 5 SN - 0302-2838, 0302-2838 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Lymph nodes KW - Pelvis KW - Positron emission tomography KW - Prognosis KW - Prostate cancer KW - Regression analysis KW - Retroperitoneum KW - Surgery KW - Survival KW - prostate-specific antigen KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1238122552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Urology&rft.atitle=Pelvic%2FRetroperitoneal+Salvage+Lymph+Node+Dissection+for+Patients+Treated+With+Radical+Prostatectomy+With+Biochemical+Recurrence+and+Nodal+Recurrence+Detected+by+%5B11C%5DCholine+Positron+Emission+Tomography%2FComputed+Tomography&rft.au=Rigatti%2C+Patrizio%3BSuardi%2C+Nazareno%3BBriganti%2C+Alberto%3BPozzo%2C+Luigi+FDa%3BTutolo%2C+Manuela%3BVilla%2C+Luca%3BGallina%2C+Andrea%3BCapitanio%2C+Umberto%3BAbdollah%2C+Firas%3BScattoni%2C+Vincenzo%3BColombo%2C+Renzo%3BFreschi%2C+Massimo%3BPicchio%2C+Maria%3BMessa%2C+Cristina%3BGuazzoni%2C+Giorgio%3BMontorsi%2C+Francesco&rft.aulast=Rigatti&rft.aufirst=Patrizio&rft.date=2011-11-01&rft.volume=60&rft.issue=5&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=European+Urology&rft.issn=03022838&rft_id=info:doi/10.1016%2Fj.eururo.2011.07.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-28 N1 - SubjectsTermNotLitGenreText - Pelvis; Prostate cancer; Surgery; Computed tomography; Prognosis; Regression analysis; Positron emission tomography; Survival; prostate-specific antigen; Lymph nodes; Retroperitoneum DO - http://dx.doi.org/10.1016/j.eururo.2011.07.060 ER - TY - JOUR T1 - Achieving the Goals of the National HIV/AIDS Strategy: Keeping Gender in Mind AN - 1081897116; 201225410 AB - The vision of the National HIV/AIDS Strategy released in 2010 is discussed. Part of a special journal issue on the subject, 'Bringing Gender Home: Implementing Gender-Responsive HIV/AIDS Programming for U.S. Women and Girls', the result of a 2-day meeting in 2010, a partnership with UNAIDS and the U.S. Office on Women's Health aimed at promoting 'increased leadership in gender-responsive programming for women and girls.'. [Copyright Jacobs Institute of Women's Health; published by Elsevier Science Inc.] JF - Women's Health Issues AU - Yakovchenko, Vera AU - Valdiserri, Ronald O AD - Office of HIV/AIDS Policy, Office of the Assistant Secretary for Health, U.S. Department of Health and Human Services, 200 Independence Ave S.W. Room 443H, Washington, DC 20201. Phone: 202-205-6606; Fax: 202-690-7560 Y1 - 2011/11// PY - 2011 DA - November 2011 SP - S237 EP - S238 PB - Elsevier Science, New York NY VL - 21 IS - 6s SN - 1049-3867, 1049-3867 KW - Girls KW - Gender KW - Women KW - Women's issues KW - HIV KW - Leadership KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081897116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Women%27s+Health+Issues&rft.atitle=Achieving+the+Goals+of+the+National+HIV%2FAIDS+Strategy%3A+Keeping+Gender+in+Mind&rft.au=Yakovchenko%2C+Vera%3BValdiserri%2C+Ronald+O&rft.aulast=Yakovchenko&rft.aufirst=Vera&rft.date=2011-11-01&rft.volume=21&rft.issue=6s&rft.spage=S237&rft.isbn=&rft.btitle=&rft.title=Women%27s+Health+Issues&rft.issn=10493867&rft_id=info:doi/10.1016%2Fj.whi.2011.04.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-27 N1 - CODEN - WHISEH N1 - SubjectsTermNotLitGenreText - HIV; Women; Girls; Gender; Leadership; Women's issues DO - http://dx.doi.org/10.1016/j.whi.2011.04.016 ER - TY - JOUR T1 - Veterinary Public Health Capacity in the United States: Opportunities for Improvement AN - 1030886245; 2011-233423 AB - Objectives. In 2006, the Association of American Veterinary Medical Colleges reported that the shortage (under 1,500) of public health veterinarians is expected to increase tenfold by 2020. In 2008, the Centers for Disease Control and Prevention (CDC) Preventive Medicine Fellows conducted a pilot project among CDC veterinarians to identify national veterinary public health workforce concerns and potential policy strategies. Methods. Fellows surveyed a convenience sample (19/91) of public health veterinarians at CDC to identify veterinary workforce recruitment and retention problems faced by federal agencies; responses were categorized into themes. A focus group (20/91) of staff veterinarians subsequently prioritized the categorized themes from least to most important. Participants identified activities to address the three recruitment concerns with the highest combined weight. Results. Participants identified the following three highest prioritized problems faced by federal agencies when recruiting veterinarians to public health: (1) lack of awareness of veterinarians' contributions to public health practice, (2) competitive salaries, and (3) employment and training opportunities. Similarly, key concerns identified regarding retention of public health practice veterinarians included: (1) lack of recognition of veterinary qualifications, (2) competitive salaries, and (3) seamless integration of veterinary and human public health. Conclusions. Findings identified multiple barriers that can affect recruitment and retention of veterinarians engaged in public health practice. Next steps should include replicating project efforts among a national sample of public health veterinarians. A committed and determined long-term effort might be required to sustain initiatives and policy proposals to increase U.S. veterinary public health capacity. Adapted from the source document. JF - Public Health Reports AU - Jarman, Dwayne W AU - Liang, Jennifer L AU - Luce, Richard R AU - Wright, Jennifer G AU - Stennies, Gail M AU - Bisgard, Kristine M AD - U.S. Food and Drug Administration, Office of Regulatory Affairs dwayne.jarman@fda.hhs.gov Y1 - 2011/11// PY - 2011 DA - November 2011 SP - 868 EP - 874 PB - Association of Schools of Public Health, Washington DC VL - 126 IS - 6 SN - 0033-3549, 0033-3549 KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Health conditions and policy - Diseases and disorders KW - Labor conditions and policy - Employment and labor supply KW - Social conditions and policy - Associations and meetings KW - United States KW - Public health education KW - Associations KW - Medicine KW - Employment KW - Diseases KW - Qualifications KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030886245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Veterinary+Public+Health+Capacity+in+the+United+States%3A+Opportunities+for+Improvement&rft.au=Jarman%2C+Dwayne+W%3BLiang%2C+Jennifer+L%3BLuce%2C+Richard+R%3BWright%2C+Jennifer+G%3BStennies%2C+Gail+M%3BBisgard%2C+Kristine+M&rft.aulast=Jarman&rft.aufirst=Dwayne&rft.date=2011-11-01&rft.volume=126&rft.issue=6&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Public health; Public health education; Diseases; Medicine; United States; Employment; Associations; Qualifications ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF [alpha],[Beta]-THUJONE (CAS NO. 76231-76-0) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 1011582003; 22127327 AB - α,β-Thujone is a component of the essential oils of some plants including wormwood, sage, and cedar. It is used in herbal medicines, food and flavoring, and notably as the principal ingredient of the liqueur absinthe. We studied the effects of α,β-thujone on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing α,β-thujone in methylcellulose through a tube directly into the stomach to groups of 50 male and female rats and mice five days per week for two years. Exposed rats received either 12.5, 25, or 50 milligrams of α,β-thujone per kilogram of body weight, and mice received 3, 6, 12, or 25 mg/kg. Control animals received methylcellulose with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. All male and female rats receiving 50 mg/kg α,β-thujone died before the end of the study. All of those animals, and most receiving 25 mg/kg, experienced seizures. In male rats there was an increased incidence of cancers of the preputial gland and a slight increase in the incidence of pheochromocytomas of the adrenal gland. Nearly all male and female mice receiving 25 mg/kg α,β-thujone experienced seizures, and all of the female mice receiving 25 mg/kg died before the end of the study. No increases in cancers were observed in female rats or in male or female mice. We conclude that α,β-thujone caused cancers of the preputial gland in male rats, and an increase in adrenal gland tumors in male rats may have been related to α,β-thujone administration. There was no increase in cancer incidence in female rats or male or female mice. Seizures were seen in almost all rats and mice receiving the highest doses of α,β-thujone. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1 EP - 260 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Monoterpenes KW - Mutagens KW - beta-thujone KW - Cancer KW - Food additives KW - Toxicity KW - Human exposure KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Seizures -- chemically induced KW - Monoterpenes -- toxicity KW - Pheochromocytoma -- chemically induced KW - Adrenal Gland Neoplasms -- chemically induced KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011582003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+%5Balpha%5D%2C%5BBeta%5D-THUJONE+%28CAS+NO.+76231-76-0%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Document feature - Tables; References; Graphs; Diagrams N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - ERRATUM AN - 1011477061 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 261 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=ERRATUM&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1011477060 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1011477059 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/11// PY - 2011 DA - Nov 2011 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1011477059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-11-01&rft.volume=&rft.issue=570&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2011 N1 - Last updated - 2015-03-22 ER - TY - CPAPER T1 - Federal Perspective on the MCH Workforce T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313017707; 6051561 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kavanagh, Laura Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313017707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Perspective+on+the+MCH+Workforce&rft.au=Kavanagh%2C+Laura&rft.aulast=Kavanagh&rft.aufirst=Laura&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Latino Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015987; 6049202 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mora, Sonia Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Latino+Communities+Working+to+Achieve+Better+Health&rft.au=Mora%2C+Sonia&rft.aulast=Mora&rft.aufirst=Sonia&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Asian American Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015737; 6049201 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chan, Chun Man Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Social aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Asian+American+Communities+Working+to+Achieve+Better+Health&rft.au=Chan%2C+Chun+Man&rft.aulast=Chan&rft.aufirst=Chun&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - African American Communities Working to Achieve Better Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313015678; 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6049573 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Choi, Colleen AU - Hua, Jiaying AU - Erlandson, Diane AU - Monickam, Sarah AU - West, William Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Health care KW - Data banks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313013475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+Querying+and+Reporting+to+the+National+Practitioner+Data+Bank+and+the+Healthcare+Integrity+Protection+Data+Bank&rft.au=Choi%2C+Colleen%3BHua%2C+Jiaying%3BErlandson%2C+Diane%3BMonickam%2C+Sarah%3BWest%2C+William&rft.aulast=Choi&rft.aufirst=Colleen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - International recruitment of health workers: A view from the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313011792; 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6048908 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Paxman, Dalton Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Heaths UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Viewing+heath+improvement+through+a+regional+and+local+lens&rft.au=Paxman%2C+Dalton&rft.aulast=Paxman&rft.aufirst=Dalton&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Healthy People 2020: Prevention roadmap to better health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313007075; 6048907 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Blakey, Carter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prevention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313007075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Prevention+roadmap+to+better+health&rft.au=Blakey%2C+Carter&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Application of IVD Testing in Therapeutic Trials T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006234; 6051085 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Mansfield, Elizabeth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Application+of+IVD+Testing+in+Therapeutic+Trials&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Progress Moving Forward with the National Partnership for Action T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313006162; 6048939 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Graham, Garth AU - Rollins, Rochelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313006162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Progress+Moving+Forward+with+the+National+Partnership+for+Action&rft.au=Graham%2C+Garth%3BRollins%2C+Rochelle&rft.aulast=Graham&rft.aufirst=Garth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Hepatitis B in the Asian-American Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313005212; 6048633 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Brickham, Tamara AU - Hsu, Chiehwen AU - Yang, Shiou- Bih AU - Shen, Whey AU - Chen, Shane AU - Ajani, Shahnaz AU - Turner, Cynthia AU - McNeese-Ward, Marlene Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - hepatitis B KW - Hepatitis B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313005212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Hepatitis+B+in+the+Asian-American+Community&rft.au=Brickham%2C+Tamara%3BHsu%2C+Chiehwen%3BYang%2C+Shiou-+Bih%3BShen%2C+Whey%3BChen%2C+Shane%3BAjani%2C+Shahnaz%3BTurner%2C+Cynthia%3BMcNeese-Ward%2C+Marlene&rft.aulast=Brickham&rft.aufirst=Tamara&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Health IT and Disparities, Relevant Federal Initiatives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313002394; 6050134 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gerdine, Miryam Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313002394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Health+IT+and+Disparities%2C+Relevant+Federal+Initiatives&rft.au=Gerdine%2C+Miryam&rft.aulast=Gerdine&rft.aufirst=Miryam&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Utilization of electronic field medical surveillance in international disaster response; an assessment of data utility in the 2010 Haiti Earthquake T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1313001775; 6051258 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Passman, Dina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Caribbean Sea, Greater Antilles, Haiti KW - Earthquakes KW - Seismic activity KW - Disasters KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313001775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Utilization+of+electronic+field+medical+surveillance+in+international+disaster+response%3B+an+assessment+of+data+utility+in+the+2010+Haiti+Earthquake&rft.au=Passman%2C+Dina&rft.aulast=Passman&rft.aufirst=Dina&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Faces of Black Lung T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312998673; 6050323 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wolfe, Anita AU - Petsonk, Edward AU - Urban, Charles Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Lung KW - Black lung UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312998673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Faces+of+Black+Lung&rft.au=Wolfe%2C+Anita%3BPetsonk%2C+Edward%3BUrban%2C+Charles&rft.aulast=Wolfe&rft.aufirst=Anita&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Addressing Racial/Ethnic Disparities in Cancer Screenings Among Health Center Patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997937; 6051297 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Ngo-Metzger, Quyen Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Cancer KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Addressing+Racial%2FEthnic+Disparities+in+Cancer+Screenings+Among+Health+Center+Patients&rft.au=Ngo-Metzger%2C+Quyen&rft.aulast=Ngo-Metzger&rft.aufirst=Quyen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Reducing Disparities in Access to Primary Care and Patient Satisfaction: The Role of Health Centers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997684; 6051295 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lebrun, Lydie Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Reducing+Disparities+in+Access+to+Primary+Care+and+Patient+Satisfaction%3A+The+Role+of+Health+Centers&rft.au=Lebrun%2C+Lydie&rft.aulast=Lebrun&rft.aufirst=Lydie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Implementation Model for CLASS Act T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312997201; 6049992 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Wren, John Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312997201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Implementation+Model+for+CLASS+Act&rft.au=Wren%2C+John&rft.aulast=Wren&rft.aufirst=John&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bright Futures for Women's Health and Wellness (BFWHW) Initiative - Emotional Wellness Consumer Tools Evaluation & Findings T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312996679; 6051869 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rice, Morrisa AU - Mehta, Shalini Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Emotions KW - Consumers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312996679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Bright+Futures+for+Women%27s+Health+and+Wellness+%28BFWHW%29+Initiative+-+Emotional+Wellness+Consumer+Tools+Evaluation+%26amp%3B+Findings&rft.au=Rice%2C+Morrisa%3BMehta%2C+Shalini&rft.aulast=Rice&rft.aufirst=Morrisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Putting the Public Health into Mental Health: Screening Children and Adolescents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995454; 6048448 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rubenstein, Lisa AU - Lulow, Eric AU - Jensen, Peter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Adolescents KW - Public health KW - Children KW - Mental disorders KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Putting+the+Public+Health+into+Mental+Health%3A+Screening+Children+and+Adolescents&rft.au=Rubenstein%2C+Lisa%3BLulow%2C+Eric%3BJensen%2C+Peter&rft.aulast=Rubenstein&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Developing standard case definitions of newborn screening disorders for epidemiological surveillance T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312995019; 6051759 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Sarkar, Deboshree AU - Copeland, Sara Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Neonates KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312995019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Developing+standard+case+definitions+of+newborn+screening+disorders+for+epidemiological+surveillance&rft.au=Sarkar%2C+Deboshree%3BCopeland%2C+Sara&rft.aulast=Sarkar&rft.aufirst=Deboshree&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - CHCs, MU, & PCMH: An Alphabet Soup that Translates into Patient-Centered, High Quality Health Care for the Community T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992810; 6048382 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Harris, Yael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Health care KW - Soups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=CHCs%2C+MU%2C+%26amp%3B+PCMH%3A+An+Alphabet+Soup+that+Translates+into+Patient-Centered%2C+High+Quality+Health+Care+for+the+Community&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Modifying the behavior of food employees using training materials and methods designed for oral culture learners T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312992569; 6051199 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pittman, JoAnn Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Training KW - Education KW - Food KW - Personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312992569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Modifying+the+behavior+of+food+employees+using+training+materials+and+methods+designed+for+oral+culture+learners&rft.au=Pittman%2C+JoAnn&rft.aulast=Pittman&rft.aufirst=JoAnn&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Evaluation Strategy for the Teen Pregnancy Prevention Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312990712; 6050808 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Trivits, Lisa AU - Chamberlain, Seth AU - Margolis, Amy AU - Tevendale, Heather AU - Tyson, Diana AU - Hershey, Alan AU - Kelsey, Meredith AU - Knab, Jean AU - Layzer, Jean AU - Trenholm, Chris AU - Goerlich Zief, Susan Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - prevention KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312990712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Evaluation+Strategy+for+the+Teen+Pregnancy+Prevention+Program&rft.au=Trivits%2C+Lisa%3BChamberlain%2C+Seth%3BMargolis%2C+Amy%3BTevendale%2C+Heather%3BTyson%2C+Diana%3BHershey%2C+Alan%3BKelsey%2C+Meredith%3BKnab%2C+Jean%3BLayzer%2C+Jean%3BTrenholm%2C+Chris%3BGoerlich+Zief%2C+Susan&rft.aulast=Trivits&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Protecting and Promoting the Total Health of Workers: Keys to a Healthier, Safer and More Engaged Workforce T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312989078; 6051818 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Nigam, Jeannie AU - Schill, Anita Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Keys KW - Workers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312989078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Protecting+and+Promoting+the+Total+Health+of+Workers%3A+Keys+to+a+Healthier%2C+Safer+and+More+Engaged+Workforce&rft.au=Nigam%2C+Jeannie%3BSchill%2C+Anita&rft.aulast=Nigam&rft.aufirst=Jeannie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Utilizing prenatal screening, social networking, and community partnerships to conduct investigations: A unique public health cluster T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312987663; 6049592 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hines Jr, Robert AU - Sackett, Shawta AU - Doty, Virginia AU - Chronister, Karen AU - McNeese-Ward, Marlene Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - prenatal experience KW - networking KW - Social organization KW - Screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312987663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Utilizing+prenatal+screening%2C+social+networking%2C+and+community+partnerships+to+conduct+investigations%3A+A+unique+public+health+cluster&rft.au=Hines+Jr%2C+Robert%3BSackett%2C+Shawta%3BDoty%2C+Virginia%3BChronister%2C+Karen%3BMcNeese-Ward%2C+Marlene&rft.aulast=Hines+Jr&rft.aufirst=Robert&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National Efforts to Increase Integration of Oral Health into School Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312986918; 6049070 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Vodicka, Pamella Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - schools KW - Integration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+Efforts+to+Increase+Integration+of+Oral+Health+into+School+Health&rft.au=Vodicka%2C+Pamella&rft.aulast=Vodicka&rft.aufirst=Pamella&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Patient safety collaborative: Rapid-cycle implementation of safe medication practices in communities nationwide T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312986809; 6049039 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lai, Eric AU - Kwon, Linda AU - Williams, Karen Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312986809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Patient+safety+collaborative%3A+Rapid-cycle+implementation+of+safe+medication+practices+in+communities+nationwide&rft.au=Lai%2C+Eric%3BKwon%2C+Linda%3BWilliams%2C+Karen&rft.aulast=Lai&rft.aufirst=Eric&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Characterization of adult blood lead levels below 25 mcg/dL in the New Hampshire Adult Blood Lead Epidemiology and Surveillance Program (ABLES) Program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312984912; 6051581 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Armenti, Karla AU - Allison, Suzanne AU - Caron, Rosemary AU - Lakevicius, Paul AU - Foley, Tim Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA, New Hampshire KW - Blood levels KW - Epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312984912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Characterization+of+adult+blood+lead+levels+below+25+mcg%2FdL+in+the+New+Hampshire+Adult+Blood+Lead+Epidemiology+and+Surveillance+Program+%28ABLES%29+Program&rft.au=Armenti%2C+Karla%3BAllison%2C+Suzanne%3BCaron%2C+Rosemary%3BLakevicius%2C+Paul%3BFoley%2C+Tim&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Successful Implementation of PrEP within the National HIV/AIDS Strategy T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312983819; 6050732 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Valdiserri, Ronald Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Human immunodeficiency virus KW - Acquired immune deficiency syndrome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312983819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Successful+Implementation+of+PrEP+within+the+National+HIV%2FAIDS+Strategy&rft.au=Valdiserri%2C+Ronald&rft.aulast=Valdiserri&rft.aufirst=Ronald&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Importance of community engagement in the movement to eliminate hepatitis B disparities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312980632; 6050344 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Chan, Chun Man Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - hepatitis B KW - community involvement KW - Hepatitis B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312980632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Importance+of+community+engagement+in+the+movement+to+eliminate+hepatitis+B+disparities&rft.au=Chan%2C+Chun+Man&rft.aulast=Chan&rft.aufirst=Chun&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - OMH's Role in the HHS Oral Health Initiative T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312980535; 6051828 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rollins, Rochelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312980535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=OMH%27s+Role+in+the+HHS+Oral+Health+Initiative&rft.au=Rollins%2C+Rochelle&rft.aulast=Rollins&rft.aufirst=Rochelle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Population-based surveillance for methicillin-resistant Staphylococcus aureus infections among high school football and wrestling participants--Nebraska, 2008-2010 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312978855; 6048953 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Buss, Bryan AU - Safranek, Thomas Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - infection KW - antibiotic resistance KW - Infection KW - Drug resistance KW - Staphylococcus aureus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312978855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Population-based+surveillance+for+methicillin-resistant+Staphylococcus+aureus+infections+among+high+school+football+and+wrestling+participants--Nebraska%2C+2008-2010&rft.au=Buss%2C+Bryan%3BSafranek%2C+Thomas&rft.aulast=Buss&rft.aufirst=Bryan&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - A Cultural and Linguistic Competency Resource Center to Facilitate the Elimination of Health Inequities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312977114; 6051284 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - culture KW - Language UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312977114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=A+Cultural+and+Linguistic+Competency+Resource+Center+to+Facilitate+the+Elimination+of+Health+Inequities&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Health Policy Making: Clinician Turned Wonk T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976117; 6048891 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Margolis, Gregg Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - health policy KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Health+Policy+Making%3A+Clinician+Turned+Wonk&rft.au=Margolis%2C+Gregg&rft.aulast=Margolis&rft.aufirst=Gregg&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Bringing scientific, clinical and public health expertise to the policy process T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312976080; 6048890 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Kaplowitz, Lisa Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312976080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Bringing+scientific%2C+clinical+and+public+health+expertise+to+the+policy+process&rft.au=Kaplowitz%2C+Lisa&rft.aulast=Kaplowitz&rft.aufirst=Lisa&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using the principles of health literacy to drive positive dietary behavior change T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975777; 6048984 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Butner, Katrina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Diets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Using+the+principles+of+health+literacy+to+drive+positive+dietary+behavior+change&rft.au=Butner%2C+Katrina&rft.aulast=Butner&rft.aufirst=Katrina&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Electronic Health Record: Implications for Occupational Safety and Health Surveillance T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312975222; 6048775 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Souza, Kerry AU - Storey, Eileen AU - Filios, Margaret Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Occupational safety KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312975222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Electronic+Health+Record%3A+Implications+for+Occupational+Safety+and+Health+Surveillance&rft.au=Souza%2C+Kerry%3BStorey%2C+Eileen%3BFilios%2C+Margaret&rft.aulast=Souza&rft.aufirst=Kerry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National Release of the Leading Health Indicators from Healthy People 2020 T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312974596; 6048595 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Koh, Howard Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312974596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+Release+of+the+Leading+Health+Indicators+from+Healthy+People+2020&rft.au=Koh%2C+Howard&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Prevalence and correlates of having serious thoughts of suicide in the past year among community-dwelling adults in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312972324; 6050511 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Han, Beth AU - Barker, Peggy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - suicide KW - Suicide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312972324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Prevalence+and+correlates+of+having+serious+thoughts+of+suicide+in+the+past+year+among+community-dwelling+adults+in+the+United+States&rft.au=Han%2C+Beth%3BBarker%2C+Peggy&rft.aulast=Han&rft.aufirst=Beth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building a Health IT Workforce To Meet the Needs of Underserved Communities T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312971262; 6049333 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Harris, Yael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312971262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+a+Health+IT+Workforce+To+Meet+the+Needs+of+Underserved+Communities&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Fostering healthy Tribal communities: Developing a model for Tribal advocacy for HIV/AIDS prevention, education, and testing T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968485; 6049827 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bennett-Barnes, Evonne Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Human immunodeficiency virus KW - prevention KW - Education KW - Acquired immune deficiency syndrome KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Fostering+healthy+Tribal+communities%3A+Developing+a+model+for+Tribal+advocacy+for+HIV%2FAIDS+prevention%2C+education%2C+and+testing&rft.au=Bennett-Barnes%2C+Evonne&rft.aulast=Bennett-Barnes&rft.aufirst=Evonne&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Healthy People 2020: Target setting for the dietary intake objectives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312968421; 6050699 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Juan, WenYen AU - Crane, Nancy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Ingestion KW - Diets KW - Dietary intake UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312968421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Healthy+People+2020%3A+Target+setting+for+the+dietary+intake+objectives&rft.au=Juan%2C+WenYen%3BCrane%2C+Nancy&rft.aulast=Juan&rft.aufirst=WenYen&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Community Health Applied Research Network: A marriage of community health centers with academic health centers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967745; 6050721 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Felix, Kaytura Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - marriage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Community+Health+Applied+Research+Network%3A+A+marriage+of+community+health+centers+with+academic+health+centers&rft.au=Felix%2C+Kaytura&rft.aulast=Felix&rft.aufirst=Kaytura&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Trends in Disparities in Healthcare Associated Infections T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967644; 6050718 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Moy, Ernest Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - infection KW - Health care KW - Infection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+Disparities+in+Healthcare+Associated+Infections&rft.au=Moy%2C+Ernest&rft.aulast=Moy&rft.aufirst=Ernest&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Racial/Ethnic Patterns of Illicit Drug Use Disorders among Adolescents and Adults in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967493; 6051654 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Muhuri, Pradip Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Adolescents KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Racial%2FEthnic+Patterns+of+Illicit+Drug+Use+Disorders+among+Adolescents+and+Adults+in+the+United+States&rft.au=Muhuri%2C+Pradip&rft.aulast=Muhuri&rft.aufirst=Pradip&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Asbestosis and Malignant Mesothelioma Mortality in the United States: An update T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312967127; 6051586 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bang, Ki AU - Mazurek, Jacek AU - Wassell, James AU - Wood, John AU - Syamlal, Girija Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Mortality KW - mesothelioma KW - Asbestosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312967127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Asbestosis+and+Malignant+Mesothelioma+Mortality+in+the+United+States%3A+An+update&rft.au=Bang%2C+Ki%3BMazurek%2C+Jacek%3BWassell%2C+James%3BWood%2C+John%3BSyamlal%2C+Girija&rft.aulast=Bang&rft.aufirst=Ki&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Integrating and evaluating social media as a part of your communications package: The honeymoon is over T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312964965; 6049065 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Burnett, Garrett Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication KW - Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Integrating+and+evaluating+social+media+as+a+part+of+your+communications+package%3A+The+honeymoon+is+over&rft.au=Burnett%2C+Garrett&rft.aulast=Burnett&rft.aufirst=Garrett&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Lessons Learned at NIOSH: Using the Tools of Social Media to Build our Community of Practice T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312964926; 6049064 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Lum, Max Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312964926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Lessons+Learned+at+NIOSH%3A+Using+the+Tools+of+Social+Media+to+Build+our+Community+of+Practice&rft.au=Lum%2C+Max&rft.aulast=Lum&rft.aufirst=Max&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Federal Behavioral Health Statistics: Using Data from the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Behavioral Health Statistics and Quality in Public Behavioral Health Surveillance, Policy Making, and Planning T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312963171; 6048531 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Smith, Kelley AU - Delany, Peter Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - substance abuse KW - Statistics KW - Data processing KW - Mental disorders KW - Drug abuse KW - Public health KW - Policies KW - National planning KW - Biological surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312963171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Federal+Behavioral+Health+Statistics%3A+Using+Data+from+the+Substance+Abuse+and+Mental+Health+Services+Administration%27s+%28SAMHSA%29+Center+for+Behavioral+Health+Statistics+and+Quality+in+Public+Behavioral+Health+Surveillance%2C+Policy+Making%2C+and+Planning&rft.au=Smith%2C+Kelley%3BDelany%2C+Peter&rft.aulast=Smith&rft.aufirst=Kelley&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - An innovative approach to promoting equity and addressing disparities: The National Network to Eliminate Disparities in Behavioral Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312963129; 6048799 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Huang, Larke AU - Dutta, Trina Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312963129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=An+innovative+approach+to+promoting+equity+and+addressing+disparities%3A+The+National+Network+to+Eliminate+Disparities+in+Behavioral+Health&rft.au=Huang%2C+Larke%3BDutta%2C+Trina&rft.aulast=Huang&rft.aufirst=Larke&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - How the HHS HAI NAP is Morphing into the Partnership for Patients T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962885; 6049324 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Battles, James Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=How+the+HHS+HAI+NAP+is+Morphing+into+the+Partnership+for+Patients&rft.au=Battles%2C+James&rft.aulast=Battles&rft.aufirst=James&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Understanding Health Promotion in the African American Church T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962663; 6050357 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Tilson, Wilma Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Africa KW - health promotion KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Understanding+Health+Promotion+in+the+African+American+Church&rft.au=Tilson%2C+Wilma&rft.aulast=Tilson&rft.aufirst=Wilma&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Black and white rates of low birth weight, preterm birth, and infant mortality by state and county: A mid-decade evaluation of progress toward Healthy People 2010 objectives and the goal of disparity elimination T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312962026; 6051801 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Schempf, Ashley AU - Kramer, Michael AU - Ghandour, Reem AU - Mendola, Pauline AU - Schoendorf, Kenneth Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - low-birth-weight KW - infant mortality KW - Pregnancy KW - Birth weight KW - Mortality KW - Infants KW - Parturition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312962026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Black+and+white+rates+of+low+birth+weight%2C+preterm+birth%2C+and+infant+mortality+by+state+and+county%3A+A+mid-decade+evaluation+of+progress+toward+Healthy+People+2010+objectives+and+the+goal+of+disparity+elimination&rft.au=Schempf%2C+Ashley%3BKramer%2C+Michael%3BGhandour%2C+Reem%3BMendola%2C+Pauline%3BSchoendorf%2C+Kenneth&rft.aulast=Schempf&rft.aufirst=Ashley&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Intervention Dimensions: Building a sustainable school based program and study to improve family disaster preparedness actions T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312961105; 6051370 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gilmore, Melanie AU - Foreman, Faith AU - Obregon, Misael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Emergency preparedness KW - Sustainable development KW - intervention KW - schools KW - Disasters UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312961105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Intervention+Dimensions%3A+Building+a+sustainable+school+based+program+and+study+to+improve+family+disaster+preparedness+actions&rft.au=Gilmore%2C+Melanie%3BForeman%2C+Faith%3BObregon%2C+Misael&rft.aulast=Gilmore&rft.aufirst=Melanie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Leadership Development for Community Health Improvement - KPHLI Experience T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312955562; 6049703 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Srinivasan, Jayaram Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312955562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Leadership+Development+for+Community+Health+Improvement+-+KPHLI+Experience&rft.au=Srinivasan%2C+Jayaram&rft.aulast=Srinivasan&rft.aufirst=Jayaram&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - National CLAS Standards Enhancement Initiative: An HHS Office of Minority Health Initiative to Advance Culturally and Linguistically Appropriate Health Services T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312954258; 6051052 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312954258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=National+CLAS+Standards+Enhancement+Initiative%3A+An+HHS+Office+of+Minority+Health+Initiative+to+Advance+Culturally+and+Linguistically+Appropriate+Health+Services&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Show Me How T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312944294; 6050600 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Bechard, Michelle Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312944294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Show+Me+How&rft.au=Bechard%2C+Michelle&rft.aulast=Bechard&rft.aufirst=Michelle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Trends in prevalence and incidence of and factors associated with nonmedical use of prescription pain relievers among adults aged 50 or older in the United States T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312942772; 6049682 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Han, Beth AU - Gfroerer, Joe Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - pain KW - Pain UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312942772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Trends+in+prevalence+and+incidence+of+and+factors+associated+with+nonmedical+use+of+prescription+pain+relievers+among+adults+aged+50+or+older+in+the+United+States&rft.au=Han%2C+Beth%3BGfroerer%2C+Joe&rft.aulast=Han&rft.aufirst=Beth&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Social Media Strategy at AIDS.gov T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312940854; 6049514 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Gomez, Miguel Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312940854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Social+Media+Strategy+at+AIDS.gov&rft.au=Gomez%2C+Miguel&rft.aulast=Gomez&rft.aufirst=Miguel&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Use of Patient Navigators as a Strategy to Increase Access to Care for Health Disparities Populations T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312937424; 6048761 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Peplinski, Kyle AU - McLeod, Caroline AU - Stark, Debra Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312937424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Use+of+Patient+Navigators+as+a+Strategy+to+Increase+Access+to+Care+for+Health+Disparities+Populations&rft.au=Peplinski%2C+Kyle%3BMcLeod%2C+Caroline%3BStark%2C+Debra&rft.aulast=Peplinski&rft.aufirst=Kyle&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Occupational Surveillance of Young U.S. Workers T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312924505; 6050037 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Hollenbeck, Julie AU - Caban-Martinez, Alberto AU - Fleming, Lora AU - LeBlanc, William AU - Christ, Sharon AU - Clarke, Tainya AU - Kachan, Diana AU - McCollister, Katherine AU - Arheart, Kristopher AU - Goodman, Elizabeth AU - Zimmerman, Frederick AU - Muntaner, Carles AU - Lee, David Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - USA KW - Workers KW - Surveillance and enforcement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312924505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Occupational+Surveillance+of+Young+U.S.+Workers&rft.au=Hollenbeck%2C+Julie%3BCaban-Martinez%2C+Alberto%3BFleming%2C+Lora%3BLeBlanc%2C+William%3BChrist%2C+Sharon%3BClarke%2C+Tainya%3BKachan%2C+Diana%3BMcCollister%2C+Katherine%3BArheart%2C+Kristopher%3BGoodman%2C+Elizabeth%3BZimmerman%2C+Frederick%3BMuntaner%2C+Carles%3BLee%2C+David&rft.aulast=Hollenbeck&rft.aufirst=Julie&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - HRSA Perspective and the IOM Oral Health Reports T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312923420; 6049620 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Adirim, Terry Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=HRSA+Perspective+and+the+IOM+Oral+Health+Reports&rft.au=Adirim%2C+Terry&rft.aulast=Adirim&rft.aufirst=Terry&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Building Healthy Communities: The National CLAS Standards Enhancement Initiative to Advance Health Equity at Every Point of Contact T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312923060; 6049556 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Pacheco, Guadalupe AU - Jacobs, C Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health KW - Nutrition KW - Sports KW - Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312923060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Building+Healthy+Communities%3A+The+National+CLAS+Standards+Enhancement+Initiative+to+Advance+Health+Equity+at+Every+Point+of+Contact&rft.au=Pacheco%2C+Guadalupe%3BJacobs%2C+C&rft.aulast=Pacheco&rft.aufirst=Guadalupe&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Medicare hospices that focus on nursing facility residents T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312922932; 6048862 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Nudelman, Jodi AU - Seife, Meridith AU - Harrison, Nancy AU - Herman, Olivia AU - Goldberg, Rose AU - Rubin, Michael Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Nursing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312922932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Medicare+hospices+that+focus+on+nursing+facility+residents&rft.au=Nudelman%2C+Jodi%3BSeife%2C+Meridith%3BHarrison%2C+Nancy%3BHerman%2C+Olivia%3BGoldberg%2C+Rose%3BRubin%2C+Michael&rft.aulast=Nudelman&rft.aufirst=Jodi&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - BodyWorks: Evaluating both parent and adolescent involvement in a family-based, healthy lifestyle program T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312921467; 6049102 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Abercrombie, R AU - Fishman, Jodie AU - Book, Amanda Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312921467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=BodyWorks%3A+Evaluating+both+parent+and+adolescent+involvement+in+a+family-based%2C+healthy+lifestyle+program&rft.au=Abercrombie%2C+R%3BFishman%2C+Jodie%3BBook%2C+Amanda&rft.aulast=Abercrombie&rft.aufirst=R&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Domestic and international efforts in mental health by the National Institute of Mental Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312906977; 6051431 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Collins, Pamela Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - mental disorders KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312906977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Domestic+and+international+efforts+in+mental+health+by+the+National+Institute+of+Mental+Health&rft.au=Collins%2C+Pamela&rft.aulast=Collins&rft.aufirst=Pamela&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Public Health Quality: A National Framework and Criteria to Aid in Selecting Community Benefit and Community Building Activities that Improve Community Health T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312905617; 6051121 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Honore, Peggy Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312905617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Public+Health+Quality%3A+A+National+Framework+and+Criteria+to+Aid+in+Selecting+Community+Benefit+and+Community+Building+Activities+that+Improve+Community+Health&rft.au=Honore%2C+Peggy&rft.aulast=Honore&rft.aufirst=Peggy&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Improving Health Literacy at All Levels: The National Action Plan to Improve Health Literacy and Healthy People 2020 Health Communication and Health IT Objectives T2 - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AN - 1312903554; 6050386 JF - 139th American Public Health Association Annual Meeting and Exposition (APHA 2011) AU - Rowden, Jessica Y1 - 2011/10/29/ PY - 2011 DA - 2011 Oct 29 KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312903554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.atitle=Improving+Health+Literacy+at+All+Levels%3A+The+National+Action+Plan+to+Improve+Health+Literacy+and+Healthy+People+2020+Health+Communication+and+Health+IT+Objectives&rft.au=Rowden%2C+Jessica&rft.aulast=Rowden&rft.aufirst=Jessica&rft.date=2011-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=139th+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/139am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quality by Design for DPIs -A Regulatory Perspective T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313033904; 6080161 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Peri, Prasad Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Chemical engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313033904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Quality+by+Design+for+DPIs+-A+Regulatory+Perspective&rft.au=Peri%2C+Prasad&rft.aulast=Peri&rft.aufirst=Prasad&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quality by Design (QbD) Opportunities, Challenges and Future Direction T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313024885; 6080080 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Nasr, Moheb Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Chemical engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313024885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Quality+by+Design+%28QbD%29+Opportunities%2C+Challenges+and+Future+Direction&rft.au=Nasr%2C+Moheb&rft.aulast=Nasr&rft.aufirst=Moheb&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Challenges, Opportunities, and Scientific Aspects of Implementing PAT In Biopharmaceuticals T2 - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AN - 1313022761; 6080153 JF - 2011 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2011) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2011/10/16/ PY - 2011 DA - 2011 Oct 16 KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313022761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.atitle=Challenges%2C+Opportunities%2C+and+Scientific+Aspects+of+Implementing+PAT+In+Biopharmaceuticals&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2011-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2011+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2011%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aiche.org/conferences/annualmeeting/meetingprogram/2011topical.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation AN - 1221142638; 15747062 AB - Advances in predicting in vivo performance of drug products has the potential to change how drug products are developed and reviewed. Modeling and simulation methods are now more commonly used in drug product development and regulatory drug review. These applications include, but are not limited to: the development of biorelevant specifications, the determination of bioequivalence metrics for modified release products with rapid therapeutic onset, the design of in vitro-in vivo correlations in a mechanistic framework, and prediction of food effect. As new regulatory concepts such as quality by design require better application of biopharmaceutical modeling in drug product development, regulatory challenges in bioequivalence demonstration of complex drug products also present exciting opportunities for creative modeling and simulation approaches. A collaborative effort among academia, government and industry in modeling and simulation will result in improved safe and effective new/generic drugs to the American public. JF - International Journal of Pharmaceutics AU - Jiang, Wenlei AU - Kim, Stephanie AU - Zhang, Xinyuan AU - Lionberger, Robert A AU - Davit, Barbara M AU - Conner, Dale P AU - Yu, Lawrence X Y1 - 2011/10/14/ PY - 2011 DA - 2011 Oct 14 SP - 151 EP - 160 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 418 IS - 2 SN - 0378-5173, 0378-5173 KW - Biotechnology and Bioengineering Abstracts KW - Development KW - Drug development KW - Drugs KW - Food KW - Pharmaceuticals KW - Reviews KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1221142638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Pharmaceutics&rft.atitle=The+role+of+predictive+biopharmaceutical+modeling+and+simulation+in+drug+development+and+regulatory+evaluation&rft.au=Jiang%2C+Wenlei%3BKim%2C+Stephanie%3BZhang%2C+Xinyuan%3BLionberger%2C+Robert+A%3BDavit%2C+Barbara+M%3BConner%2C+Dale+P%3BYu%2C+Lawrence+X&rft.aulast=Jiang&rft.aufirst=Wenlei&rft.date=2011-10-14&rft.volume=418&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2011.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2012-12-04 N1 - SubjectsTermNotLitGenreText - Food; Reviews; Pharmaceuticals; Drug development; Development; Drugs DO - http://dx.doi.org/10.1016/j.ijpharm.2011.07.024 ER - TY - JOUR T1 - Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days. AN - 885908956; 21784140 AB - A number of studies have demonstrated that co-exposure to low levels of melamine and cyanuric acid elicits renal toxicity due to the formation of melamine cyanurate crystals in the kidney nephrons. In this work, we investigated if co-exposure of rats to these compounds leads to alterations in the expression of the genes encoding kidney injury molecule 1 (KIM-1), metallopeptidase inhibitor 1 (TIMP1), clusterin, osteopontin, and neutrophil gelatinase-associated lipocalin/lipocalin 2 (NGAL), which have been proposed as urinary biomarkers for nephrotoxicity. Six-week-old male and female F344 rats were fed ad libitum a diet fortified with 0 (control), 7, 23, 69, 229, or 694 ppm melamine and cyanuric acid (co-exposure groups), 1388 ppm melamine, or 1388 ppm cyanuric acid for seven days. Histopathology and clinical chemistry examination indicated marked toxicity only in the animals exposed to the two highest combined doses of melamine and cyanuric acid. Consistent with these observations, quantitative real-time polymerase chain reaction analysis of kidney tissue indicated increased expression of all genes analyzed relative to the control in both male and female rats fed daily with 229 or 694 ppm melamine and cyanuric acid. Exposure to lower levels of both compounds or to the individual compounds did not induce gene expression changes. These data indicate that quantifying the expression levels of the selected biomarker genes constitutes a useful endpoint to assess the combined toxicity of melamine and cyanuric acid in both male and female rats. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Camacho, Luísa AU - Kelly, Kevin P AU - Beland, Frederick A AU - Gamboa da Costa, Gonçalo AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. luisa.camacho@fda.hhs.gov Y1 - 2011/10/10/ PY - 2011 DA - 2011 Oct 10 SP - 166 EP - 171 VL - 206 IS - 2 KW - Acute-Phase Proteins KW - 0 KW - Biomarkers KW - Cell Adhesion Molecules KW - Clu protein, rat KW - Clusterin KW - Environmental Pollutants KW - Havcr1protein, rat KW - Lcn2 protein, rat KW - Lipocalin-2 KW - Lipocalins KW - Proto-Oncogene Proteins KW - RNA, Messenger KW - Spp1 protein, rat KW - Tissue Inhibitor of Metalloproteinase-1 KW - Triazines KW - neutrophil gelatinase-associated lipocalin protein, rat KW - Osteopontin KW - 106441-73-0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Animals KW - Cell Adhesion Molecules -- genetics KW - Acute-Phase Proteins -- genetics KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Osteopontin -- metabolism KW - Proto-Oncogene Proteins -- metabolism KW - Osteopontin -- genetics KW - Clusterin -- genetics KW - Lipocalins -- metabolism KW - Rats KW - Rats, Inbred F344 KW - No-Observed-Adverse-Effect Level KW - RNA, Messenger -- metabolism KW - Tissue Inhibitor of Metalloproteinase-1 -- metabolism KW - Clusterin -- metabolism KW - Biomarkers -- metabolism KW - Cell Adhesion Molecules -- metabolism KW - Lipocalins -- genetics KW - Proto-Oncogene Proteins -- genetics KW - Acute-Phase Proteins -- metabolism KW - Tissue Inhibitor of Metalloproteinase-1 -- genetics KW - Male KW - Female KW - Triazines -- toxicity KW - Renal Insufficiency -- metabolism KW - Kidney -- metabolism KW - Environmental Pollutants -- toxicity KW - Renal Insufficiency -- chemically induced KW - Kidney -- drug effects KW - Gene Expression Regulation -- drug effects KW - Environmental Pollutants -- administration & dosage KW - Triazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885908956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Gene+expression+of+biomarkers+of+nephrotoxicity+in+F344+rats+co-exposed+to+melamine+and+cyanuric+acid+for+seven+days.&rft.au=Camacho%2C+Lu%C3%ADsa%3BKelly%2C+Kevin+P%3BBeland%2C+Frederick+A%3BGamboa+da+Costa%2C+Gon%C3%A7alo&rft.aulast=Camacho&rft.aufirst=Lu%C3%ADsa&rft.date=2011-10-10&rft.volume=206&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2011.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-21 N1 - Date created - 2011-08-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods. 2001 Dec;25(4):402-8 [11846609] Toxicol Sci. 2011 Feb;119(2):391-7 [21030430] IARC Sci Publ. 1991;(115):171-86 [1820332] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] J Vet Diagn Invest. 2007 Nov;19(6):616-24 [17998549] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] Toxicology. 2008 Apr 18;246(2-3):91-100 [18289764] Kidney Int. 2008 May;73(9):994-1007 [18272962] Toxicol Sci. 2008 Jun;103(2):371-81 [18308701] Toxicol Sci. 2008 Nov;106(1):251-62 [18689873] Toxicology. 2009 Nov 9;265(1-2):15-26 [19761811] Toxicol Pathol. 2010 Apr;38(3):338-45 [20305092] Nat Biotechnol. 2010 May;28(5):455-62 [20458315] Nat Biotechnol. 2010 May;28(5):478-85 [20458318] Nat Biotechnol. 2010 May;28(5):486-94 [20458319] Pharmacol Res. 2010 Sep;62(3):179-86 [20434560] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2011.07.009 ER - TY - JOUR T1 - Admissions for CABG Procedure in the Elderly: Was There a Change in Access to Teaching Hospitals After 1997? AN - 964195448; 201201445 AB - The purpose of the study is to identify patient attributes associated with teaching hospital admissions in the elderly for coronary artery bypass graft (CABG), and to determine whether admission patterns in teaching hospitals by vulnerable subgroups of the elderly changed during 1997 to 2001, a period with significant changes in CABG admission patterns and financial situation faced by teaching hospitals. The study sample comprises elderly residents in two states, New York and Pennsylvania, and uses Healthcare Cost and Utilization Project State Inpatient data of the Agency for Health Care Research and Quality. Patient characteristics in major teaching hospitals are compared with those in rest of hospitals in a logistic regression framework using a pre-/postdesign, and controlling for county characteristics and resources, distance to hospitals, and hospital size and volume of procedures. Significant patient characteristics associated with a higher likelihood of admission to teaching hospitals included racial/ethnic minority status, transfer cases, Medicaid and private health maintenance organization Insurance. A lower volume of CABG cases and an increased propensity to admit more complex cases characterized the admission patterns in teaching hospitals during 1997 to 2001. Although higher use of teaching hospitals by racial/ethnic minorities persisted, access for Medicaid patients disproportionately declined. Adapted from the source document. JF - Social Work in Public Health AU - Basu, Jayasree AD - Senior Economist, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Jbasu@ahrq.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 605 EP - 620 PB - Taylor & Francis, Philadelphia PA VL - 26 IS - 6 SN - 1937-1918, 1937-1918 KW - Elderly, access, health care organization, hospital performance, cardiac procedure KW - Minority Groups KW - Teaching KW - Quality of Health Care KW - Ethnicity KW - Medicaid KW - Patients KW - Health Care Utilization KW - Health Care Services KW - Hospitals KW - article KW - 6124: health care promotion/education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964195448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Public+Health&rft.atitle=Admissions+for+CABG+Procedure+in+the+Elderly%3A+Was+There+a+Change+in+Access+to+Teaching+Hospitals+After+1997%3F&rft.au=Basu%2C+Jayasree&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2011-10-01&rft.volume=26&rft.issue=6&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Public+Health&rft.issn=19371918&rft_id=info:doi/10.1080%2F19371911003748778 LA - English DB - Social Services Abstracts N1 - Date revised - 2014-02-21 N1 - Number of references - 22 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Hospitals; Teaching; Patients; Health Care Services; Ethnicity; Minority Groups; Medicaid; Quality of Health Care; Health Care Utilization DO - http://dx.doi.org/10.1080/19371911003748778 ER - TY - JOUR T1 - The Health Insurance Status of Low-Wage Workers: The Role of Workplace Composition and Marital Status AN - 927830496; 201120979 AB - Many of the provisions in the Affordable Care Act (ACA), such as tax credits and penalties for employers, vary by employer size and average wage level. Therefore, knowing the wage and firm size distribution of low-wage workers and how employer-sponsored insurance (ESI) characteristics vary by these dimensions is particularly important for understanding the extent to which low-wage workers and their employers may be affected by different provisions in the ACA. To inform this issue, the authors use data from the 2006 Medical Expenditure Panel Survey-Insurance Component to examine offers of coverage and cost-sharing requirements by the wage distribution and firm size dimensions of employers. They also draw on Medical Expenditure Panel Survey household-level data to describe the household circumstances of low-wage workers. The authors find that where low-wage workers are employed, who their colleagues are, and their spouses' wage levels are important factors in determining low-wage workers' access to coverage and the cost and generosity of such coverage. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Vistnes, Jessica AU - Monheit, Alan C AD - Agency for Healthcare Research and Quality, Rockville, MD, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 607 EP - 623 PB - Sage Publications, Thousand Oaks CA VL - 68 IS - 5 SN - 1077-5587, 1077-5587 KW - health insurance low-wage workers employment-related coverage KW - Businesses KW - Coverage KW - Expenditure KW - Wages KW - Composition KW - Penalties KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/927830496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=The+Health+Insurance+Status+of+Low-Wage+Workers%3A+The+Role+of+Workplace+Composition+and+Marital+Status&rft.au=Vistnes%2C+Jessica%3BMonheit%2C+Alan+C&rft.aulast=Vistnes&rft.aufirst=Jessica&rft.date=2011-10-01&rft.volume=68&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558711401918 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-11-02 N1 - Number of references - 7 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Wages; Coverage; Businesses; Expenditure; Composition; Penalties DO - http://dx.doi.org/10.1177/1077558711401918 ER - TY - JOUR T1 - CO and CO (sub 2) emissions from spontaneous heating of coal under different ventilation rates AN - 925702930; 2012-027735 AB - Carbon monoxide (CO) and carbon dioxide (CO (sub 2) ) emissions during a spontaneous heating event in a coal mine are important gases to monitor for detecting the spontaneous heating at an early stage. However, in underground coal mines, the CO and CO (sub 2) concentrations and their related fire ratios may be affected by mine ventilation. In this study, CO and CO (sub 2) emissions from spontaneous heating of a U.S. coal sample were evaluated in an isothermal oven under different airflow ventilation rates ranging from 100 to 500 cm (super 3) /min. Laboratory experiments were conducted at oven temperatures of 70, 90, and 100 degrees C. The temperature at the center of the coal sample was continually monitored, while the CO, CO (sub 2) , and oxygen (O (sub 2) ) concentrations of the exit gas were continually measured. The results indicate that CO was generated immediately after the airflow passed through the coal, while CO (sub 2) was generated in a late phase. The amounts of CO generated under different airflow rates were approximately the same at the initial temperature of 70 degrees C, while the amounts of CO generated increased significantly as the airflow rates and initial temperatures increased. The ratio of CO/CO (sub 2) was found to be independent of airflow rate and initial temperature, approaching a constant value of 0.2 quickly if there was no thermal runaway. The value tended to decrease when a thermal runaway took place. The CO/O (sub 2) deficiency ratio was dependent on both airflow rates and the initial temperature. The experimental results are in qualitative agreement with some large-scale test and field monitoring results. JF - International Journal of Coal Geology AU - Yuan, Liming AU - Smith, Alex C Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 24 EP - 30 PB - Elsevier, Amsterdam VL - 88 IS - 1 SN - 0166-5162, 0166-5162 KW - mines KW - experimental studies KW - coal mines KW - techniques KW - spontaneous heating KW - temperature KW - gases KW - carbon dioxide KW - ventilation KW - laboratory studies KW - carbon monoxide KW - sedimentary rocks KW - safety KW - detection KW - coal KW - heating KW - thermal effects KW - instruments KW - 06B:Petrology of coal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/925702930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=CO+and+CO+%28sub+2%29+emissions+from+spontaneous+heating+of+coal+under+different+ventilation+rates&rft.au=Yuan%2C+Liming%3BSmith%2C+Alex+C&rft.aulast=Yuan&rft.aufirst=Liming&rft.date=2011-10-01&rft.volume=88&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2011.07.004 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2012-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - carbon dioxide; carbon monoxide; coal; coal mines; detection; experimental studies; gases; heating; instruments; laboratory studies; mines; safety; sedimentary rocks; spontaneous heating; techniques; temperature; thermal effects; ventilation DO - http://dx.doi.org/10.1016/j.coal.2011.07.004 ER - TY - JOUR T1 - Using Sentinel Surveillance System to Monitor Seasonal and Novel H1N1 Influenza Infection in Houston, Texas: Outcome Analysis of 2008-2009 Flu Season AN - 919905340; 201200520 AB - The advent of the novel H1N1 virus prompted the Houston Department of Health and Human services (HDHHS) to use the existing sentinel surveillance system to effectively monitor the situation of novel H1N1 virus in the Houston metropolitan area. The objective of this study was to evaluate the demographic characteristics and common symptoms associated with confirmed cases of seasonal influenza and Novel H1N1 virus reported to HDHHS between October 2008 and October 2009. A total of 30 providers were randomly selected using the probability proportional to size (PPS) sampling technique to participate in a sentinel surveillance system. The system was used to effectively monitor both seasonal and novel H1N1 virus in the Houston metropolitan area. These providers collected and submitted specimens for testing at HDHHS laboratory from patients with influenza-like illness (ILI) symptoms who visited their clinics during the period, October 2008 and October 2009. These data formed the basis of the current study. Data obtained were subjected to both descriptive and inferential statistical analyses using SAS software version 9.1.3. Overall a total of 1,122 ILI cases were reported to HDHHS by sentinel providers and tested by HDHHS laboratory. Of this number 296 (67.5%) specimens tested positive for influenza A; 140 (32.0%) for influenza B, and 2 (0.46%) for influenza A/B. Two hundred and fifty-nine (59%) were confirmed cases of seasonal influenza and 179 (41%) were novel H1N1 subtype, respectively. The median ages for seasonal influenza and novel H1N1 virus were 7 and 8 years, with majority of the cases reported among children of age 5-9 years. Fever was the most common symptom reported among patients with seasonal flu and novel H1N1 virus, followed by cough. Twenty-three percent (23%) of patients who were vaccinated against seasonal flu prior to the epidemic were infected with seasonal flu virus. The sentinel surveillance system provided timely data on the circulating ILI that assisted in making decisions regarding response activities for both seasonal and novel H1N1 influenza. Adapted from the source document. JF - Journal of Community Health AU - Khuwaja, Salma AU - Mgbere, Osaro AU - Awosika-Olumo, Adebowale AU - Momin, Fayaz AU - Ngo, Katherine AD - Bureau of Epidemiology, Houston Department of Health and Human Services (HDHHS), 8000 N. Stadium Drive, Houston, TX, 77054, USA Salma.khuwaja@houstontx.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 857 EP - 863 PB - Springer, New York NY VL - 36 IS - 5 SN - 0094-5145, 0094-5145 KW - Influenza KW - Symptoms KW - Epidemics KW - Patients KW - Computer Software KW - Illness KW - Metropolitan Areas KW - Sociodemographic Factors KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/919905340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Using+Sentinel+Surveillance+System+to+Monitor+Seasonal+and+Novel+H1N1+Influenza+Infection+in+Houston%2C+Texas%3A+Outcome+Analysis+of+2008-2009+Flu+Season&rft.au=Khuwaja%2C+Salma%3BMgbere%2C+Osaro%3BAwosika-Olumo%2C+Adebowale%3BMomin%2C+Fayaz%3BNgo%2C+Katherine&rft.aulast=Khuwaja&rft.aufirst=Salma&rft.date=2011-10-01&rft.volume=36&rft.issue=5&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-011-9386-2 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-02-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JCMHBR N1 - SubjectsTermNotLitGenreText - Influenza; Symptoms; Patients; Metropolitan Areas; Health Care Services; Sociodemographic Factors; Epidemics; Computer Software; Illness DO - http://dx.doi.org/10.1007/s10900-011-9386-2 ER - TY - JOUR T1 - Periodic Spirometry in Occupational Setting Improving Quality, Accuracy, and Precision AN - 912920591; 16044336 AB - Objective: Effectiveness of periodic spirometry in medical monitoring depends on spirometry quality. We describe an intervention on spirometry quality and its impact on accuracy and precision of longitudinal measurements. Methods: The intervention was conducted from 2005 to 2010 in a monitoring program involving approximately 2500 firefighters. Intervention supported adherence to 2005 American Thoracic Society/European Respiratory Society recommendations through monitoring of spirometry quality and longitudinal data precision, technician training, change of spirometer, and quality control. Results: The percentage of forced vital capacity tests meeting the American Thoracic Society/European Respiratory Society criteria increased from 60% to 95% and the mean longitudinal forced expiratory volume in 1 second within-person variation decreased from 6% to 4%. The increased accuracy and precision of measurements and estimated rates of forced expiratory volume in 1 second decline were statistically significant. Conclusion: Monitoring of quality and data precision helped to recognize the need for intervention. The intervention improved accuracy and precision of spirometry measurements and their usefulness. JF - Journal of Occupational and Environmental Medicine AU - Hnizdo, E AU - Hakobyan, A AU - Fleming, J L AU - Beeckman-Wagner, L-A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA, ehnizdo@cdc.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1205 EP - 1209 VL - 53 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - firefighter services KW - Training KW - intervention KW - Quality control KW - technicians KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/912920591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Periodic+Spirometry+in+Occupational+Setting+Improving+Quality%2C+Accuracy%2C+and+Precision&rft.au=Hnizdo%2C+E%3BHakobyan%2C+A%3BFleming%2C+J+L%3BBeeckman-Wagner%2C+L-A&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2011-10-01&rft.volume=53&rft.issue=10&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31823078b8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - firefighter services; Training; Quality control; intervention; technicians DO - http://dx.doi.org/10.1097/JOM.0b013e31823078b8 ER - TY - JOUR T1 - Preparation of reference strains for validation and comparison of mycoplasma testing methods AN - 911155899; 15993857 AB - Aims: To optimize growth conditions for preparation of stocks of mycoplasma reference strains to obtain highly viable and disperse samples with low ratios of genomic copy (GC) number to that of colony forming units (CFU). These stocks are required for assessment of relative limits of detection (LOD) of alternative nucleic acid testing (NAT)-based methods in comparison to the conventional microbiological methods. Methods and Results: A kinetics study was used to assess the changes in ratios between the numbers of GC and CFU at different growth phases of six different mycoplasma cultures Acholeplasma laidlawii, Mycoplasma gallisepticum, Mycoplasma arginini, Mycoplasma fermentans, Mycoplasma orale and Mycoplasma pneumoniae. All tested mycoplasmas demonstrated low GC/CFU ratios ( less than or equal to 10) within the log and early stationary growth phases. A significant increase in GC/CFU ratios was observed at the very late stationary and death phases, when the titre of cultures has declined. Similar patterns of GC/CFU profiles were observed for A. laidlawii and Myc. gallisepticum co-cultured with suspension of Chinese hamster ovary (CHO) cells. Conclusions: Tested mycoplasma strains harvested at the exponential-early stationary phases of growth demonstrated the lowest GC/CFU ratios and low propensity to form filamentous structures or aggregates under proposed conditions and can be used for the preparation of a mycoplasma reference panel for methods comparability study. Significance and Impact of the Study: This study shows that the preparation and use of viable mycoplasma reference strains with low CG/CFU ratios is the most reliable way to adequately evaluate the LOD of alternative NAT-based mycoplasma testing methods. JF - Journal of Applied Microbiology AU - Dabrazhynetskaya, A AU - Volokhov, D V AU - David, S W AU - Ikonomi, P AU - Brewer, A AU - Chang, A AU - Chizhikov, V AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 904 EP - 914 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 111 IS - 4 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Growth conditions KW - Acholeplasma laidlawii KW - Cell culture KW - Mycoplasma pneumoniae KW - stationary phase KW - Myc protein KW - Guanylate cyclase KW - Colonies KW - Mycoplasma fermentans KW - nucleic acids KW - Colony-forming cells KW - Kinetics KW - genomics KW - Mycoplasma arginini KW - Mycoplasma gallisepticum KW - J 02410:Animal Diseases KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Preparation+of+reference+strains+for+validation+and+comparison+of+mycoplasma+testing+methods&rft.au=Dabrazhynetskaya%2C+A%3BVolokhov%2C+D+V%3BDavid%2C+S+W%3BIkonomi%2C+P%3BBrewer%2C+A%3BChang%2C+A%3BChizhikov%2C+V&rft.aulast=Dabrazhynetskaya&rft.aufirst=A&rft.date=2011-10-01&rft.volume=111&rft.issue=4&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fj.1365-2672.2011.05108.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 6 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Myc protein; stationary phase; Guanylate cyclase; Colonies; nucleic acids; Growth conditions; Kinetics; Colony-forming cells; Cell culture; genomics; Mycoplasma fermentans; Acholeplasma laidlawii; Mycoplasma pneumoniae; Mycoplasma gallisepticum; Mycoplasma arginini DO - http://dx.doi.org/10.1111/j.1365-2672.2011.05108.x ER - TY - JOUR T1 - Levels of microbial agents in floor dust during remediation of a water-damaged office building AN - 911153708; 15993764 AB - Abstract We examined the effects of remediation on loads of culturable fungi in floor dust collected from a large water-damaged office building during four cross-sectional surveys (2002, 2004, 2005, and 2007, respectively). We created a binary remediation variable for each year for each sampled workstation using information on remediation associated with water damage obtained from building management and used generalized linear mixed-effects models. We found significantly lower levels of culturable total and hydrophilic fungi at remediated workstations than at non-remediated workstations in 2004 and 2005 after completion of major remediation. The remediation effect, however, disappeared in 2007. The fraction of hydrophilic to total fungal concentrations was lowest in 2004, increased in 2005, and was highest in 2007. Our results indicate that the 2003 remediation lowered dust indices of dampness temporarily, but remediation was incomplete, consistent with a building assessment report of water infiltration. This study demonstrates the utility of longitudinal evaluation of microbial indices during remediation of water damage in this building, in which elimination of sources of moisture was not fully addressed. Our findings indicate that the fraction of hydrophilic fungi derived from concentrations of fungal species may be a useful index for assessing the long-term effectiveness of remediation. This study demonstrates the utility of longitudinal evaluation of microbial indices during remediation of water damage in this building, in which elimination of sources of moisture was incomplete. Our findings indicate that the fraction of hydrophilic fungi derived from concentrations of fungal species may be a useful index for assessing the long-term effectiveness of remediation. JF - Indoor Air AU - Cho, S J AU - Park, J-H AU - Kreiss, K AU - Cox-Ganser, J M AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 417 EP - 426 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 21 IS - 5 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts KW - Bioremediation KW - Fungi KW - Infiltration KW - Indoor environments KW - Water infiltration KW - Dust KW - Models KW - P 0000:AIR POLLUTION KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911153708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Levels+of+microbial+agents+in+floor+dust+during+remediation+of+a+water-damaged+office+building&rft.au=Cho%2C+S+J%3BPark%2C+J-H%3BKreiss%2C+K%3BCox-Ganser%2C+J+M&rft.aulast=Cho&rft.aufirst=S&rft.date=2011-10-01&rft.volume=21&rft.issue=5&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fj.1600-0668.2011.00722.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 3 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fungi; Water infiltration; Dust; Models; Bioremediation; Infiltration; Indoor environments DO - http://dx.doi.org/10.1111/j.1600-0668.2011.00722.x ER - TY - JOUR T1 - Clinical and molecular aspects of malaria fever AN - 907181496; 15749674 AB - Although clinically benign, malaria fever is thought to have significant relevance in terms of parasite growth and survival and its virulence which in turn may alter the clinical course of illness. In this article, the historical literature is reviewed, providing some evolutionary perspective on the genesis and biological relevance of malaria fever, and the available molecular data on the febrile-temperature-inducible parasite factors that may contribute towards the regulation of parasite density and alteration of virulence in the host is also discussed. The potential molecular mechanisms that could be responsible for the induction and regulation of cyclical malaria fevers caused by different species of Plasmodium are also discussed. JF - Trends in Parasitology AU - Oakley, Miranda S AU - Gerald, Noel AU - McCutchan, Thomas F AU - Aravind, L AU - Kumar, Sanjai Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 442 EP - 449 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 27 IS - 10 SN - 1471-4922, 1471-4922 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Molecular modelling KW - Parasites KW - Human diseases KW - Data processing KW - Survival KW - Malaria KW - Hosts KW - Public health KW - Fever KW - Virulence KW - Plasmodium KW - Growth KW - Reviews KW - Evolution KW - Benign KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907181496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Parasitology&rft.atitle=Clinical+and+molecular+aspects+of+malaria+fever&rft.au=Oakley%2C+Miranda+S%3BGerald%2C+Noel%3BMcCutchan%2C+Thomas+F%3BAravind%2C+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2011-10-01&rft.volume=27&rft.issue=10&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Trends+in+Parasitology&rft.issn=14714922&rft_id=info:doi/10.1016%2Fj.pt.2011.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Virulence; Parasites; Growth; Human diseases; Malaria; Hosts; Evolution; Public health; Fever; Molecular modelling; Data processing; Reviews; Survival; Benign; Plasmodium DO - http://dx.doi.org/10.1016/j.pt.2011.06.004 ER - TY - JOUR T1 - Fluoroquinolone-Associated Myasthenia Gravis Exacerbation: Evaluation of Postmarketing Reports from the US FDA Adverse Event Reporting System and a Literature Review AN - 902363626; 15813490 AB - Background Exacerbations of myasthenia gravis have been reported in antibacterial-treated patients. In animal and in vitro models of experimentally-induced myasthenia gravis, fluoroquinolones exhibit neuromuscular blockade. Objective The aim of this retrospective study was to evaluate postmarketing adverse event reports submitted to the US FDA and case reports published in the scientific literature for a potential association between fluoroquinolone exposure and acute exacerbations of myasthenia gravis. Methods On 1 March 2011, we searched the FDA Adverse Event Reporting System (AERS) database to retrieve all reports of myasthenia gravis exacerbation as a serious adverse event in patients treated with fluoroquinolones. We also conducted an Internet-based search using EMBASE for additional English-language cases in the scientific literature. Results We identified a total of 37 unique cases describing myasthenia gravis exacerbation following fluoroquinolone systemic exposure. We retrieved AERS reports for 27 non-ventilated patients administered the following fluoroquinolones: levofloxacin (n = 9), moxifloxacin (n = 6), ciprofloxacin (n = 6), ofloxacin (n = 2), gatifloxacin (n = 2), norfloxacin (n = 1) and trovafloxacin (n = 1). Additionally, we retrieved ten case reports published in the literature involving non-ventilated patients administered ciprofloxacin (n = 4), levofloxacin (n = 2) and ofloxacin, norfloxacin, pefloxacin and prulifloxacin (1 patient each). Myasthenia gravis exacerbations developed a median of 1 day following fluoroquinolone exposure. The 37 cases describe dyspnoea (n = 19; 51%), myasthenic crisis requiring ventilatory support (n = 11; 30%) and death (n = 2; 5%). Additional exacerbation-related adverse events were generalized muscle weakness (n = 20; 54%), dysphagia (n = 9; 24%), diplopia (n = 6; 16%) and ptosis (n = 6; 16%). Six patients (16%) experienced a positive rechallenge, with recurrent myasthenia gravis exacerbation after fluoroquinolone reintroduction. Conclusions Fluoroquinolone exposure may result in potentially life-threatening myasthenia gravis exacerbations in patients with underlying disease. Healthcare professionals should be aware of this serious drug-disease association and carefully weigh the benefit-risks of fluoroquinolones when treating infections in non-ventilated myasthenic patients. JF - Drug Safety AU - Jones, S Christopher AU - Sorbello, Alfred AU - Boucher, Robert M AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Division of Pharmacovigilance II, Silver Spring, MD, USA Y1 - 2011/10/01/ PY - 2011 DA - 2011 Oct 01 SP - 839 EP - 847 PB - Adis International Inc. VL - 34 IS - 10 SN - 0114-5916, 0114-5916 KW - CSA Neurosciences Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Case reports KW - Ciprofloxacin KW - Databases KW - Dysphagia KW - Dyspnea KW - FDA KW - Fluoroquinolones KW - Gatifloxacin KW - Levofloxacin KW - Literature reviews KW - Medical personnel KW - Mortality KW - Moxifloxacin KW - Muscles KW - Myasthenia gravis KW - Neuromuscular junctions KW - Norfloxacin KW - Ofloxacin KW - Pefloxacin KW - Reintroduction KW - Respiration KW - Reviews KW - Side effects KW - Trovafloxacin KW - crises KW - infection KW - reintroduction KW - USA KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902363626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Safety&rft.atitle=Fluoroquinolone-Associated+Myasthenia+Gravis+Exacerbation%3A+Evaluation+of+Postmarketing+Reports+from+the+US+FDA+Adverse+Event+Reporting+System+and+a+Literature+Review&rft.au=Jones%2C+S+Christopher%3BSorbello%2C+Alfred%3BBoucher%2C+Robert+M&rft.aulast=Jones&rft.aufirst=S&rft.date=2011-10-01&rft.volume=34&rft.issue=10&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=Drug+Safety&rft.issn=01145916&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/adis/dsf/2011/00000034/00000010/art00004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - Reintroduction; Norfloxacin; Fluoroquinolones; Respiration; Levofloxacin; Ofloxacin; Muscles; Pefloxacin; Gatifloxacin; Databases; Ciprofloxacin; Dysphagia; Trovafloxacin; Case reports; Literature reviews; Moxifloxacin; Myasthenia gravis; Neuromuscular junctions; Dyspnea; Mortality; Reviews; crises; infection; FDA; Medical personnel; Side effects; reintroduction; USA ER - TY - JOUR T1 - Systemic cytokine levels and subsequent risk of gastric cancer in Chinese Women. AN - 895854949; 21740481 AB - Although control of the host cytokine network is known to influence gastric cancer susceptibility, the specific inflammatory responses in gastric carcinogenesis remain unclear. We prospectively examined the relationships between gastric cancer risk and plasma levels of interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α in a nested case control study within The Shanghai Women's Health Study. Two controls were matched to each case on the basis of age, menopausal status, and sample collection parameters. The associations between gastric cancer risk and tertiles of cytokine levels were estimated by odds ratios (OR) and 95% confidence intervals (CI) from conditional logistic regression, adjusting for education. During a median follow-up period of 4 years (range 0.1-8 years), 141 women developed gastric cancer and were matched to 282 cancer-free study participants. Elevated levels of plasma IL-6 were associated with an increased risk of gastric cancer (P(trend) = 0.04). Risk increased 70% (OR = 1.7; 95% CI 1.0, 3.0) for women in the highest tertile (>4 pg/mL) of IL-6 compared with those in the lowest tertile (<1.8 pg/mL). The association between gastric cancer risk and IL-6 was stronger after 4 years of follow-up (OR = 2.6 [95% CI 1.0, 6.7] for highest versus lowest tertile) compared with an OR of 1.4 (95% CI 0.7, 2.9) for those diagnosed within 1-4 years of follow-up. No associations were observed with the other pro-inflammatory cytokines examined, namely IL-1β, IL-8, and TNF-α. Systemic plasma IL-6 levels may inform long-term gastric cancer risk. This novel finding awaits confirmation in future studies with sequential plasma collection. © 2011 Japanese Cancer Association and this article is a US Government work and is in the public domain in the USA. JF - Cancer science AU - Wong, Hui-Lee AU - Rabkin, Charles S AU - Shu, Xiao-Ou AU - Pfeiffer, Ruth M AU - Cai, Qiuyin AU - Ji, Bu-Tian AU - Yang, Gong AU - Li, Hong-Lan AU - Rothman, Nathaniel AU - Gao, Yu-Tang AU - Zheng, Wei AU - Chow, Wong-Ho AD - US Food and Drug Administration, Silver Spring, Maryland, USA. huilee.wong@fda.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1911 EP - 1915 VL - 102 IS - 10 KW - Cytokines KW - 0 KW - Interleukin-1beta KW - Interleukin-6 KW - Interleukin-8 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Helicobacter pylori KW - Odds Ratio KW - Humans KW - Aged KW - Helicobacter Infections KW - Interleukin-8 -- blood KW - Eating KW - Interleukin-6 -- blood KW - Interleukin-1beta -- blood KW - Prospective Studies KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Confidence Intervals KW - Tumor Necrosis Factor-alpha -- blood KW - Middle Aged KW - China KW - Female KW - Cytokines -- blood KW - Stomach Neoplasms -- blood KW - Stomach Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/895854949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+science&rft.atitle=Systemic+cytokine+levels+and+subsequent+risk+of+gastric+cancer+in+Chinese+Women.&rft.au=Wong%2C+Hui-Lee%3BRabkin%2C+Charles+S%3BShu%2C+Xiao-Ou%3BPfeiffer%2C+Ruth+M%3BCai%2C+Qiuyin%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLi%2C+Hong-Lan%3BRothman%2C+Nathaniel%3BGao%2C+Yu-Tang%3BZheng%2C+Wei%3BChow%2C+Wong-Ho&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2011-10-01&rft.volume=102&rft.issue=10&rft.spage=1911&rft.isbn=&rft.btitle=&rft.title=Cancer+science&rft.issn=1349-7006&rft_id=info:doi/10.1111%2Fj.1349-7006.2011.02033.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Mar 23;404(6776):398-402 [10746728] J Interferon Cytokine Res. 2001 Jan;21(1):45-52 [11177580] Urology. 2001 Dec;58(6):1008-15 [11744478] Nat Rev Cancer. 2002 Jan;2(1):28-37 [11902583] J Interferon Cytokine Res. 2002 Apr;22(4):473-82 [12034030] Nat Med. 2002 Oct;8(10):1089-97 [12219085] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Eur J Cancer. 2003 Jan;39(2):184-91 [12509950] J Surg Oncol. 2003 Aug;83(4):222-6 [12884234] World J Gastroenterol. 2004 Apr 15;10(8):1115-20 [15069709] Gut. 2004 Sep;53(9):1235-43 [15306577] IARC Monogr Eval Carcinog Risks Hum. 1994;61:177-240 [7715070] Cancer Lett. 1995 Aug 16;95(1-2):207-12 [7656232] J Clin Endocrinol Metab. 1997 Jul;82(7):2182-91 [9215292] Infect Dis Clin North Am. 1998 Mar;12(1):185-97 [9494838] J Urol. 1999 Jan;161(1):182-7 [10037394] Gastric Cancer. 2005;8(2):124-31 [15864720] Int J Immunopathol Pharmacol. 2005 Jul-Sep;18(3):457-473 [16164822] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Int J Cancer. 2006 Jun 15;118(12):3030-44 [16404738] Carcinogenesis. 2007 Jan;28(1):118-23 [16885196] Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2464-70 [18006938] Prostate Cancer Prostatic Dis. 2008;11(3):258-63 [17876341] Jpn J Clin Oncol. 2008 Sep;38(9):626-33 [18687755] Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3450-6 [19064561] Gastroenterology. 2009 May;136(6):1863-73 [19457415] Helicobacter. 2009 Oct;14(5):108-13 [19751435] Infect Immun. 2010 Jan;78(1):108-14 [19841072] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1349-7006.2011.02033.x ER - TY - JOUR T1 - Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver. AN - 894818797; 21785164 AB - Dysregulated intracellular iron homeostasis has been found not only in rodent and human hepatocellular carcinomas but also in several preneoplastic pathological states associated with hepatocarcinogenesis; however, the precise underlying mechanisms of metabolic iron disturbances in preneoplastic liver and the role of these disturbances remain unexplored. In the present study, using an in vivo model of rat hepatocarcinogenesis induced by 2-acetylaminofluorene, we found extensive alterations in cellular iron metabolism at preneoplastic stages of liver carcinogenesis. These were characterized by a substantial decrease in the levels of cytoplasmic non-heme iron in foci of initiated hepatocytes and altered expression of the major genes responsible for the proper maintenance of intracellular iron homeostasis. Gene expression analysis revealed that the decreased intracellular levels of iron in preneoplastic foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1), the only known non-heme iron exporter. Likewise, increased Fpn1 gene expression was found in vitro in TRL1215 rat liver cells with an acquired malignant phenotype, suggesting that upregulation of Fpn1 might be a specific feature of neoplastically transformed cells. Other changes observed in vivo included the downregulation of hepcidin (Hamp) gene, a key regulator of Fpn1, and this was accompanied by decreased levels of CCAAT/enhancer binding proteins alpha and beta, especially at the Hamp promoter. In conclusion, our results demonstrate the significance of altered intracellular iron metabolism in the progression of liver carcinogenesis and suggest that correction of these alterations could possibly affect liver cancer development. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Shpyleva, Svitlana I AU - Muskhelishvili, Levan AU - Tryndyak, Volodymyr P AU - Koturbash, Igor AU - Tokar, Erik J AU - Waalkes, Michael P AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 433 EP - 440 VL - 123 IS - 2 KW - Antimicrobial Cationic Peptides KW - 0 KW - Carcinogens KW - Cation Transport Proteins KW - HAMP protein, human KW - Hamp protein, rat KW - Hepcidins KW - metal transporting protein 1 KW - 2-Acetylaminofluorene KW - 9M98QLJ2DL KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Animals KW - Antimicrobial Cationic Peptides -- metabolism KW - Disease Progression KW - Liver -- metabolism KW - Cell Line, Tumor KW - Cation Transport Proteins -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Homeostasis -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Liver -- drug effects KW - Cation Transport Proteins -- metabolism KW - Male KW - Female KW - Antimicrobial Cationic Peptides -- genetics KW - Precancerous Conditions -- genetics KW - Liver Neoplasms -- metabolism KW - Hepatocytes -- drug effects KW - 2-Acetylaminofluorene -- toxicity KW - Precancerous Conditions -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Precancerous Conditions -- metabolism KW - Iron -- metabolism KW - Liver Neoplasms -- genetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894818797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chronic+administration+of+2-acetylaminofluorene+alters+the+cellular+iron+metabolism+in+rat+liver.&rft.au=Shpyleva%2C+Svitlana+I%3BMuskhelishvili%2C+Levan%3BTryndyak%2C+Volodymyr+P%3BKoturbash%2C+Igor%3BTokar%2C+Erik+J%3BWaalkes%2C+Michael+P%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Shpyleva&rft.aufirst=Svitlana&rft.date=2011-10-01&rft.volume=123&rft.issue=2&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr193 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Pathol. 1984;12(2):136-42 [11478314] Free Radic Biol Med. 2002 May 1;32(9):833-40 [11978485] J Biol Chem. 2002 Oct 25;277(43):41163-70 [12183449] Alcohol. 2003 Jun;30(2):145-50 [12957299] Gastroenterology. 2004 Nov;127(5 Suppl 1):S79-86 [15508107] J Natl Cancer Inst. 1976 Jul;57(1):157-65 [1003498] Cancer Res. 1982 Jun;42(6):2298-309 [7074612] Mutat Res. 1994 Oct;318(2):73-114 [7521935] Environ Health Perspect. 1994 Oct;102 Suppl 6:173-6 [7889843] J Biol Chem. 1995 Dec 29;270(52):31288-93 [8537397] Biochim Biophys Acta. 1997 Mar 14;1331(1):1-40 [9325434] J Biol Chem. 2006 Mar 10;281(10):6734-41 [16407263] Liver Int. 2006 Oct;26(8):976-85 [16953838] Crit Rev Toxicol. 2007 Mar;37(3):211-36 [17453932] Biochem Biophys Res Commun. 2007 Jun 8;357(3):575-8 [17434454] Arch Histol Cytol. 2007 Apr;70(1):1-19 [17558140] Br J Haematol. 2007 Jul;138(2):253-62 [17593032] Liver Int. 2007 Dec;27(10):1394-401 [17927713] Annu Rev Pathol. 2007;2:1-29 [18039091] Gastroenterology. 2008 Jan;134(1):226-38 [18166355] Carcinogenesis. 2008 Mar;29(3):638-46 [18204080] Nat Protoc. 2008;3(6):1101-8 [18546601] BMC Cancer. 2008;8:167 [18541040] Hepatology. 2008 Nov;48(5):1420-9 [18671304] Hematology Am Soc Hematol Educ Program. 2008;:151-8 [19074074] Cancer Sci. 2009 Jan;100(1):9-16 [19018762] Toxicol Lett. 2009 Feb 10;184(3):151-8 [19061943] Toxicol Appl Pharmacol. 2009 Mar 15;235(3):305-11 [19167416] Exp Biol Med (Maywood). 2009 Jun;234(6):693-702 [19307463] Biochim Biophys Acta. 2009 Jul;1790(7):650-62 [19393721] J Cancer Res Clin Oncol. 2009 Oct;135(10):1413-20 [19387685] J Leukoc Biol. 2009 Nov;86(5):1247-58 [19652026] Cancer Biol Ther. 2009 Sep;8(18):1699-708 [19571663] Cancer Lett. 2009 Dec 1;286(1):38-43 [19081672] J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 [19933942] Am J Pathol. 2010 Feb;176(2):1006-17 [20019189] Int J Cancer. 2010 Jun 1;126(11):2575-83 [19839049] Hepatology. 2010 May;51(5):1820-32 [20432259] Cell. 2010 Jul 9;142(1):24-38 [20603012] Sci Transl Med. 2010 Aug 4;2(43):43ra56 [20686179] J Hepatol. 2011 Jan;54(1):173-81 [20932599] Annu Rev Med. 2011;62:347-60 [20887198] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr193 ER - TY - JOUR T1 - miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. AN - 894816814; 21750348 AB - The role of trivalent arsenic (As(3+)) on the regulation of the recently identified noncoding small RNAs, mainly microRNAs, has not been explored so far. In the present study, we provide evidence showing that As(3+) is a potent inducer for the expression of miR-190 in human bronchial epithelial cells. The induction of miR-190 by As(3+) is concentration dependent and associated with the expression of the host gene of miR-190, talin 2, a gene encoding a high-molecular-weight cytoskeletal protein. The elevated level of miR-190 induced by As(3+) is capable of downregulating the translation of the PH domain leucine-rich repeat protein phosphatase (PHLPP), a negative regulator of Akt signaling. Such a downregulation is occurred through direct interaction of the miR-190 with the 3'-UTR region of the PHLPP mRNA, leading to a diminished PHLPP protein expression and consequently, an enhanced Akt activation and expression of vascular endothelial growth factor, an Akt-regulated protein. Overexpression of miR-190 itself is able to enhance proliferation and malignant transformation of the cells as determined by anchorage-independent growth of the cells in soft agar. Accordingly, the data presented suggest that induction of miR-190 is one of the key mechanisms in As(3+)-induced carcinogenesis. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Beezhold, Kevin AU - Liu, Jia AU - Kan, Hong AU - Meighan, Terry AU - Castranova, Vince AU - Shi, Xianglin AU - Chen, Fei AD - The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 411 EP - 420 VL - 123 IS - 2 KW - Arsenicals KW - 0 KW - Carcinogens, Environmental KW - MicroRNAs KW - Nuclear Proteins KW - Oxides KW - RNA, Messenger KW - TLN2 protein, human KW - Talin KW - PHLPP1 protein, human KW - EC 3.1.3.16 KW - Phosphoprotein Phosphatases KW - arsenic trioxide KW - S7V92P67HO KW - Index Medicus KW - Talin -- genetics KW - Cell Proliferation -- drug effects KW - Gene Silencing KW - Humans KW - Talin -- metabolism KW - Bronchi -- drug effects KW - Bronchi -- pathology KW - Arsenic Poisoning KW - Epithelial Cells -- drug effects KW - RNA, Messenger -- metabolism KW - Epithelial Cells -- pathology KW - Cell Transformation, Neoplastic -- chemically induced KW - Cell Line KW - Nuclear Proteins -- genetics KW - Phosphoprotein Phosphatases -- metabolism KW - MicroRNAs -- biosynthesis KW - Phosphoprotein Phosphatases -- genetics KW - Gene Expression Regulation -- drug effects KW - Oxides -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Nuclear Proteins -- metabolism KW - Down-Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894816814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=miR-190-mediated+downregulation+of+PHLPP+contributes+to+arsenic-induced+Akt+activation+and+carcinogenesis.&rft.au=Beezhold%2C+Kevin%3BLiu%2C+Jia%3BKan%2C+Hong%3BMeighan%2C+Terry%3BCastranova%2C+Vince%3BShi%2C+Xianglin%3BChen%2C+Fei&rft.aulast=Beezhold&rft.aufirst=Kevin&rft.date=2011-10-01&rft.volume=123&rft.issue=2&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfr188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-26 N1 - Date created - 2011-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hepatology. 2009 Apr;49(4):1098-112 [19173277] World J Surg. 2009 Apr;33(4):698-709 [19030927] Int J Cancer. 2009 Jul 15;125(2):345-52 [19378336] Gut. 2009 Oct;58(10):1375-81 [19201770] Breast Cancer Res. 2009;11(3):R27 [19432961] J Biomed Biotechnol. 2009;2009:594678 [19606257] PLoS One. 2009;4(11):e8003 [19946373] Environ Health Perspect. 2009 Nov;117(11):1718-23 [20049123] Mol Cancer. 2010;9:134 [20515486] J Biol Chem. 2010 Jul 16;285(29):21994-2002 [20457614] Chemosphere. 2011 Apr;83(3):211-25 [21216433] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1749-53 [10677529] Mol Cell. 2001 Jul;8(1):85-94 [11511362] Biochem Biophys Res Commun. 2001 Sep 7;286(5):880-5 [11527381] Cancer Res. 2003 Nov 15;63(22):7689-93 [14633691] Cell. 2003 Dec 26;115(7):787-98 [14697198] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11755-60 [15284443] EMBO J. 1996 Nov 15;15(22):6269-79 [8947050] Int J Epidemiol. 1998 Aug;27(4):561-9 [9758107] Lung Cancer. 2004 Dec;46(3):265-70 [15541810] JAMA. 2004 Dec 22;292(24):2984-90 [15613666] Nucleic Acids Res. 2005;33(4):1290-7 [15741182] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32 [15738415] Mol Cell. 2005 Apr 1;18(1):13-24 [15808505] Nat Genet. 2005 May;37(5):495-500 [15806104] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Nucleic Acids Res. 2006;34(2):485-95 [16421274] Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1042-8 [16445569] World J Gastroenterol. 2006 Feb 7;12(5):691-6 [16521180] Carcinogenesis. 2006 Apr;27(4):864-73 [16387740] Anticancer Res. 2006 Nov-Dec;26(6B):4391-5 [17201159] EMBO J. 2007 Feb 7;26(3):775-83 [17255951] Cancer Res. 2007 Jun 1;67(11):5293-9 [17545609] J Biol Chem. 2007 Aug 10;282(32):23716-24 [17569667] Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16170-5 [17911264] Exp Hematol. 2007 Nov;35(11):1708-18 [17976522] Nucleic Acids Res. 2008 Jan;36(Database issue):D707-14 [18000006] Cancer Res. 2008 Jan 15;68(2):425-33 [18199536] J Cell Sci. 2008 May 1;121(Pt 9):1345-7 [18434644] RNA. 2008 Jun;14(6):1012-7 [18426918] Cell Cycle. 2008 Jun 1;7(11):1529-38 [18469525] Environ Res. 2008 Sep;108(1):48-55 [18511031] Blood. 2008 Oct 15;112(8):3026-35 [18669872] Nat Cell Biol. 2008 Sep;10(9):1062-8 [19160486] Insect Biochem Mol Biol. 2008 Dec;38(12):1066-71 [18977439] Oncogene. 2009 Feb 19;28(7):994-1004 [19079341] J Transl Med. 2009;7:20 [19309508] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfr188 ER - TY - JOUR T1 - Poisoning hospitalisations among reproductive-aged women in the USA, 1998-2006. AN - 894040928; 21296799 AB - To describe poisoning hospitalisations among reproductive-aged women from 1998 to 2006. 1998-2006 data from the Nationwide Inpatient Sample of the Healthcare Cost and Utilisation Project were used to identify hospitalisations for poisonings among US women aged 15-44 years. Differences in hospitalisation characteristics were compared by intent using χ(2) statistics. Trends in poisoning hospitalisation rates were calculated overall and by subgroup. There were approximately 636,000 poisoning hospitalisations in women aged 15-44 years during 1998-2006. Hospitalisations for intentionally self-inflicted poisonings had a higher proportion of women aged 15-24 years and privately insured women than did unintentional poisonings (p<0.001). Poisoning hospitalisations in rural areas and those that resulted in death were more likely to be of undetermined intent than those for which intent was specified (p<0.001). Co-diagnoses of substance abuse (34.5%) or mental disorders (66.5%) were high. The rate of poisoning hospitalisations overall and unintentional poisoning hospitalisations increased 6% and 22%, respectively, during this period (p<0.001). The most frequently diagnosed poisoning agent was acetaminophen. Poisonings attributable to acetaminophen, opioids, central nervous system stimulants and benzodiazepines increased, while poisonings attributable to antidepressants decreased (p<0.05). The increase in unintentional poisoning hospitalisations among women aged 15-44 years and the changing profile of poisoning agents should inform the healthcare community's poisoning prevention strategies. Poisoning prevention strategies should include a component to address substance abuse and mental health disorders among reproductive-age women. JF - Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention AU - Cox, Shanna AU - Kuo, Cassie AU - Jamieson, Denise J AU - Kourtis, Athena P AU - McPheeters, Melissa L AU - Meikle, Susan F AU - Posner, Samuel F AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA. shanna.cox@cdc.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 332 EP - 337 VL - 17 IS - 5 KW - Index Medicus KW - Young Adult KW - Risk Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Adult KW - Self-Injurious Behavior -- epidemiology KW - Adolescent KW - United States -- epidemiology KW - Female KW - Substance-Related Disorders -- epidemiology KW - Poisoning -- epidemiology KW - Hospitalization -- statistics & numerical data KW - Hospitalization -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/894040928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.atitle=Poisoning+hospitalisations+among+reproductive-aged+women+in+the+USA%2C+1998-2006.&rft.au=Cox%2C+Shanna%3BKuo%2C+Cassie%3BJamieson%2C+Denise+J%3BKourtis%2C+Athena+P%3BMcPheeters%2C+Melissa+L%3BMeikle%2C+Susan+F%3BPosner%2C+Samuel+F&rft.aulast=Cox&rft.aufirst=Shanna&rft.date=2011-10-01&rft.volume=17&rft.issue=5&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Injury+prevention+%3A+journal+of+the+International+Society+for+Child+and+Adolescent+Injury+Prevention&rft.issn=1475-5785&rft_id=info:doi/10.1136%2Fip.2010.029793 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-12-12 N1 - Date created - 2011-09-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/ip.2010.029793 ER - TY - JOUR T1 - Effects of Orange II and Sudan III azo dyes and their metabolites on Staphylococcus aureus. AN - 893721922; 21451978 AB - Azo dyes are widely used in the plastic, paper, cosmetics, food, and pharmaceutical industries. Some metabolites of these dyes are potentially genotoxic. The toxic effects of azo dyes and their potential reduction metabolites on Staphylococcus aureus ATCC BAA 1556 were studied. When the cultures were incubated with 6, 18, and 36 μg/ml of Orange II and Sudan III for 48 h, 76.3, 68.5, and 61.7% of Orange II and 97.8, 93.9, and 75.8% of Sudan III were reduced by the bacterium, respectively. In the presence of 36 μg/ml Sudan III, the cell viability of the bacterium decreased to 61.9% after 48 h of incubation, whereas the cell viability of the control culture without the dye was 71.5%. Moreover, the optical density of the bacterial cultures at 10 h decreased from 0.74 to 0.55, indicating that Sudan III is able to inhibit growth of the bacterium. However, Orange II had no significant effects on either cell growth or cell viability of the bacterium at the tested concentrations. 1-Amino-2-naphthol, a metabolite common to Orange II and Sudan III, was capable of inhibiting cell growth of the bacterium at 1 μg/ml and completely stopped bacterial cell growth at 24-48 μg/ml. On the other hand, the other metabolites of Orange II and Sudan III, namely sulfanilic acid, p-phenylenediamine, and aniline, showed no significant effects on cell growth. p-Phenylenediamine exhibited a synergistic effect with 1-amino-2-naphthol on cell growth inhibition. All of the dye metabolites had no significant effects on cell viability of the bacterium. JF - Journal of industrial microbiology & biotechnology AU - Pan, Hongmiao AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd., Jefferson, AR 72079-9502, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1729 EP - 1738 VL - 38 IS - 10 KW - Aniline Compounds KW - 0 KW - Azo Compounds KW - Benzenesulfonates KW - Coloring Agents KW - Naphthols KW - Phenylenediamines KW - Sulfanilic Acids KW - 1-amino-2-naphthol KW - MB1ZPM5M0Z KW - sudan III KW - ND733RX3JN KW - 2-naphthol orange KW - Q1LIY3BO0U KW - aniline KW - SIR7XX2F1K KW - 4-phenylenediamine KW - U770QIT64J KW - Index Medicus KW - Sulfanilic Acids -- toxicity KW - Phenylenediamines -- toxicity KW - Naphthols -- toxicity KW - Aniline Compounds -- toxicity KW - Azo Compounds -- metabolism KW - Coloring Agents -- toxicity KW - Benzenesulfonates -- metabolism KW - Staphylococcus aureus -- growth & development KW - Azo Compounds -- toxicity KW - Coloring Agents -- metabolism KW - Staphylococcus aureus -- drug effects KW - Staphylococcus aureus -- metabolism KW - Benzenesulfonates -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893721922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Effects+of+Orange+II+and+Sudan+III+azo+dyes+and+their+metabolites+on+Staphylococcus+aureus.&rft.au=Pan%2C+Hongmiao%3BFeng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2011-10-01&rft.volume=38&rft.issue=10&rft.spage=1729&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-011-0962-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-05-11 N1 - Date created - 2011-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10295-011-0962-3 ER - TY - JOUR T1 - Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease. AN - 890678166; 21883026 AB - A key to understanding the biological function(s) of the aryl hydrocarbon receptor (AHR) - a xenobiotic-activated receptor - is to identify its endogenous ligand(s). The discovery of a tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) as an endogenous, high affinity agonist of AHR filled this knowledge gap in the context of skin physiology and pathology in response to light and opened several new directions for research on AHR. This paper reviews major developments in the study of light-elicited AHR signaling and its impact on drug metabolism, skin physiology and disease with a focus on the identification of AHR ligands from Trp photoproducts and the AHR-mediated UV response. This review consists of material obtained from Medline and PubMed literature searches up to May 2011. The recognition of FICZ as a potent, endogenous ligand of AHR provided a molecular link between light exposure and AHR signaling and function. The uncovering of the bifurcated signaling pathway of AHR in the mammalian UV response - that is, activation of the cytoplasmic AHR by light via FICZ leads to: i) AHR/AH response element-dependent transcription to induce CYP1A1 and ii) activation of the AHR-pp60(src)-EGFR pathway to induce Cox-2 - put forward a working model for the multiple roles of AHR in skin function and disease that include drug metabolism, circadian oscillation, melanogenesis, inflammation, immunosuppression and cancer. Such findings suggest AHR as a therapeutic target for cancer, autoimmune dysfunction, inflammatory disease and stem cell therapy. JF - Expert opinion on drug metabolism & toxicology AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Rd, Morgantown, WV 26505, USA. qam1@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1267 EP - 1293 VL - 7 IS - 10 KW - 6-formylindolo(3,2-b)carbazole KW - 0 KW - Carbazoles KW - Ligands KW - NF-kappa B KW - Receptors, Aryl Hydrocarbon KW - Tryptophan KW - 8DUH1N11BX KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Cytochrome P-450 CYP1A1 -- genetics KW - Humans KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Tryptophan -- metabolism KW - Skin -- radiation effects KW - Inactivation, Metabolic KW - Light KW - DNA Damage -- radiation effects KW - Signal Transduction KW - Cytochrome P-450 CYP1A1 -- drug effects KW - Immunosuppression KW - NF-kappa B -- metabolism KW - Carbazoles -- pharmacokinetics KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890678166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Influence+of+light+on+aryl+hydrocarbon+receptor+signaling+and+consequences+in+drug+metabolism%2C+physiology+and+disease.&rft.au=Ma%2C+Qiang&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2011-10-01&rft.volume=7&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2011.614947 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-20 N1 - Date created - 2011-09-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2011.614947 ER - TY - JOUR T1 - Novel hemin binding domains in the Corynebacterium diphtheriae HtaA protein interact with hemoglobin and are critical for heme iron utilization by HtaA. AN - 890032817; 21803991 AB - The human pathogen Corynebacterium diphtheriae utilizes hemin and hemoglobin as iron sources for growth in iron-depleted environments. The use of hemin iron in C. diphtheriae involves the dtxR- and iron-regulated hmu hemin uptake locus, which encodes an ABC hemin transporter, and the surface-anchored hemin binding proteins HtaA and HtaB. Sequence analysis of HtaA and HtaB identified a conserved region (CR) of approximately 150 amino acids that is duplicated in HtaA and present in a single copy in HtaB. The two conserved regions in HtaA, designated CR1 and CR2, were used to construct glutathione S-transferase (GST) fusion proteins (GST-CR1 and GST-CR2) to assess hemin binding by UV-visual spectroscopy. These studies showed that both domains were able to bind hemin, suggesting that the conserved sequences are responsible for the hemin binding property previously ascribed to HtaA. HtaA and the CR2 domain were also shown to be able to bind hemoglobin (Hb) by the use of an enzyme-linked immunosorbent assay (ELISA) method in which Hb was immobilized on a microtiter plate. The CR1 domain exhibited a weak interaction with Hb in the ELISA system, while HtaB showed no significant binding to Hb. Competitive binding studies demonstrated that soluble hemin and Hb were able to inhibit the binding of HtaA and the CR domains to immobilized Hb. Moreover, HtaA was unable to bind to Hb from which the hemin had been chemically removed. Alignment of the amino acid sequences of CR domains from various Corynebacterium species revealed several conserved residues, including two highly conserved tyrosine (Y) residues and one histidine (H) residue. Site-directed mutagenesis studies showed that Y361 and H412 were critical for the binding to hemin and Hb by the CR2 domain. Biological assays showed that Y361 was essential for the hemin iron utilization function of HtaA. Hemin transfer experiments demonstrated that HtaA was able to acquire hemin from Hb and that hemin bound to HtaA could be transferred to HtaB. These findings are consistent with a proposed mechanism of hemin uptake in C. diphtheriae in which hemin is initially obtained from Hb by HtaA and then transferred between surface-anchored proteins, with hemin ultimately transported into the cytosol by an ABC transporter. JF - Journal of bacteriology AU - Allen, Courtni E AU - Schmitt, Michael P AD - Laboratory of Respiratory and Special Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, DBPAP, CBER, FDA, Bldg. 29, Room 108, 8800 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 5374 EP - 5385 VL - 193 IS - 19 KW - Bacterial Proteins KW - 0 KW - Carrier Proteins KW - Hemeproteins KW - Hemoglobins KW - heme-binding protein KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Molecular Sequence Data KW - Enzyme-Linked Immunosorbent Assay KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Binding KW - Bacterial Proteins -- genetics KW - Carrier Proteins -- metabolism KW - Carrier Proteins -- chemistry KW - Carrier Proteins -- genetics KW - Corynebacterium diphtheriae -- metabolism KW - Bacterial Proteins -- metabolism KW - Corynebacterium diphtheriae -- genetics KW - Hemeproteins -- metabolism KW - Hemoglobins -- metabolism KW - Bacterial Proteins -- chemistry KW - Hemeproteins -- genetics KW - Heme -- metabolism KW - Hemeproteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/890032817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Novel+hemin+binding+domains+in+the+Corynebacterium+diphtheriae+HtaA+protein+interact+with+hemoglobin+and+are+critical+for+heme+iron+utilization+by+HtaA.&rft.au=Allen%2C+Courtni+E%3BSchmitt%2C+Michael+P&rft.aulast=Allen&rft.aufirst=Courtni&rft.date=2011-10-01&rft.volume=193&rft.issue=19&rft.spage=5374&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.05508-11 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-14 N1 - Date created - 2011-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Microbiol. 2000 Apr;36(1):68-84 [10760164] Infect Immun. 2010 Dec;78(12):4977-89 [20679437] Toxicon. 2001 Nov;39(11):1793-803 [11595641] DNA Cell Biol. 2002 Apr;21(4):281-95 [12042068] Infect Immun. 2002 Aug;70(8):4494-500 [12117961] Biochem Soc Trans. 2002 Aug;30(4):691-6 [12196166] Genome Biol. 2002 Aug 15;3(9):RESEARCH0047 [12225586] Microbes Infect. 2002 Sep;4(11):1149-56 [12361915] Science. 2003 Feb 7;299(5608):906-9 [12574635] Infect Immun. 2003 Mar;71(3):1042-55 [12595414] Nucleic Acids Res. 2003 Nov 15;31(22):6516-23 [14602910] J Bacteriol. 2003 Dec;185(23):6826-40 [14617647] J Biol Chem. 2004 Jan 2;279(1):436-43 [14570922] Mol Microbiol. 2004 Mar;51(5):1509-19 [14982642] Contrib Microbiol. 2005;12:210-33 [15496782] Nature. 1970 Aug 15;227(5259):680-5 [5432063] Methods Enzymol. 1981;76:72-87 [7329287] Infect Immun. 1989 Nov;57(11):3534-9 [2680975] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] Crit Rev Microbiol. 1992;18(3):217-33 [1532495] Mol Microbiol. 1993 Feb;7(3):461-9 [8384684] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9876-80 [7937909] Mol Microbiol. 1994 Aug;13(4):719-32 [7997183] J Infect Dis. 1996 Nov;174(5):1064-72 [8896510] J Bacteriol. 1997 Feb;179(3):838-45 [9006041] Infect Immun. 1997 Nov;65(11):4634-41 [9353044] J Biol Chem. 1998 Jan 9;273(2):837-41 [9422739] J Bacteriol. 2005 Jan;187(2):422-33 [15629913] Infect Immun. 2005 Aug;73(8):5086-92 [16041024] J Bacteriol. 2006 Dec;188(24):8421-9 [17041042] Am J Hematol. 2007 Feb;82(2):134-44 [16986127] Mol Microbiol. 2007 Jan;63(1):139-49 [17229211] J Bacteriol. 2007 May;189(9):3650-4 [17322319] Infect Immun. 2007 Oct;75(10):4857-66 [17664260] J Biol Chem. 2008 Mar 14;283(11):6668-76 [18184657] BMC Microbiol. 2008;8:15 [18215300] J Biol Chem. 2008 Jun 27;283(26):18450-60 [18467329] PLoS Pathog. 2008;4(8):e1000132 [18725935] Infect Immun. 2008 Nov;76(11):5006-15 [18710861] J Biol Chem. 2009 Jan 9;284(2):1166-76 [18984582] J Bacteriol. 2009 Apr;191(8):2638-48 [19201805] J Biol Chem. 2009 Nov 13;284(46):32138-46 [19759022] J Bacteriol. 2010 Jul;192(13):3503-11 [20435727] Mol Microbiol. 2010 Nov;78(3):739-56 [20807204] J Bacteriol. 2001 Feb;183(4):1476-81 [11157965] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.05508-11 ER - TY - JOUR T1 - Mortality and end-stage renal disease incidence among dry cleaning workers. AN - 889451215; 21172794 AB - Perchloroethylene (PCE) is a known animal carcinogen and probable human carcinogen. Dry cleaning exposures, particularly PCE, are also associated with renal toxicity. The objective was to follow-up a cohort of dry cleaners to evaluate mortality and assess end-stage renal disease (ESRD) morbidity. This study adds 8 years of mortality follow-up for 1704 dry cleaning workers in four cities. Employees eligible for inclusion worked for ≥1 year before 1960 in a shop using PCE as the primary solvent. Life table analyses for mortality and ESRD morbidity were conducted. Only employees alive on 1 January 1977 were included in ESRD analyses. Overall cancer deaths were in significant excess in this cohort (standardised mortality ratio (SMR) 1.22, 95% CI 1.09 to 1.36). Oesophageal, lung and tongue cancers had significant excesses of deaths. Oesophageal cancer risk was highest among those employed in a PCE-using shop for ≥5 years with ≥20 years' latency since first such employment. Deaths from non-malignant underlying diseases of the stomach and duodenum were in significant excess. Hypertensive ESRD morbidity was significantly elevated in the entire cohort (standardised incidence ratio (SIR) 1.98, 95% CI 1.11 to 3.27), and among workers employed only in PCE-using dry cleaning shops for ≥5 years. Employment in the dry cleaning industry and occupational exposure to PCE are associated with an increased risk for ESRD and for cancer at several sites. The employment duration findings for oesophageal cancer and hypertensive ESRD further support an association with PCE exposure instead of lifestyle or socioeconomic factors. JF - Occupational and environmental medicine AU - Calvert, Geoffrey M AU - Ruder, Avima M AU - Petersen, Martin R AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-17, Cincinnati, OH 45226, USA. jac6@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 709 EP - 716 VL - 68 IS - 10 KW - Solvents KW - 0 KW - Tetrachloroethylene KW - TJ904HH8SN KW - Index Medicus KW - Young Adult KW - Stomach Diseases -- chemically induced KW - Humans KW - Head and Neck Neoplasms -- chemically induced KW - Head and Neck Neoplasms -- mortality KW - Duodenal Diseases -- mortality KW - Morbidity KW - Duodenal Diseases -- chemically induced KW - Adult KW - Stomach Diseases -- mortality KW - Incidence KW - Follow-Up Studies KW - United States -- epidemiology KW - Time Factors KW - Laundering KW - Female KW - Male KW - Solvents -- toxicity KW - Occupational Exposure -- adverse effects KW - Tetrachloroethylene -- toxicity KW - Kidney Failure, Chronic -- chemically induced KW - Occupational Diseases -- chemically induced KW - Kidney Failure, Chronic -- epidemiology KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/889451215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Mortality+and+end-stage+renal+disease+incidence+among+dry+cleaning+workers.&rft.au=Calvert%2C+Geoffrey+M%3BRuder%2C+Avima+M%3BPetersen%2C+Martin+R&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2011-10-01&rft.volume=68&rft.issue=10&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foem.2010.060665 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-11-15 N1 - Date created - 2011-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/oem.2010.060665 ER - TY - JOUR T1 - Quantification of total and specific gram-negative histamine-producing bacteria species in fish using an MPN real-time PCR method AN - 888114192; 15519150 AB - Quantification of histamine-producing bacteria (HPB) is necessary in order to elucidate the role that HPB play in scombrotoxin (histamine) fish poisoning. We report here the evaluation of a real-time PCR method for the quantification of total and specific Gram-negative HPB species in fish using a most probable number (MPN) format. The species-specific real-time PCR assay was 100% inclusive for independently detecting Morganella morganii, Enterobacter aerogenes, Raoultella planticola/ornithinolytica and Photobacterium damselae and did not cross react with other histamine- or non- histamine-producing bacteria. The efficiency of the reactions in the absence and presence of Spanish mackerel enrichment containing 1 106 CFU/ml of background microflora were 93-104 and 92-99%, respectively. The MPN-real-time PCR assay accurately quantified total and specific HPB in spiked mahi-mahi (Coryphaena hippurus) and Spanish mackerel (Scomberomorus maculates) samples. These methods were used to quantify total and specific HPB in naturally contaminated, decomposing mahi-mahi, Spanish mackerel and tuna (Thunnus albacares) samples. The results of this study indicate that MPN-real-time PCR assays can be used to accurately enumerate total and specific HPB in fish samples. These assays can be applied to assess the effectiveness of mitigation strategies and understand the relationship between HPB and histamine production in decomposing fish. JF - Food Microbiology AU - Bjornsdottir-Butler, Kristin AU - Jones, Jessica L AU - Benner, Ronald A AU - Burkhardt, William Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1284 EP - 1292 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 28 IS - 7 SN - 0740-0020, 0740-0020 KW - ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Marine KW - Thunnus albacares KW - Nucleotide sequence KW - Morganella morganii KW - Poisoning KW - Raoultella planticola KW - Enterobacter aerogenes KW - Histamine KW - Marine fish KW - Photobacterium damselae KW - Most probable number KW - Coryphaena hippurus KW - Scomberomorus maculates KW - Colony-forming cells KW - Microbiology KW - Fish poisoning KW - Scomber KW - Microflora KW - DNA KW - Polymerase chain reaction KW - Histamines KW - Pollution control KW - Q1 08341:General KW - A 01330:Food Microbiology KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888114192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Quantification+of+total+and+specific+gram-negative+histamine-producing+bacteria+species+in+fish+using+an+MPN+real-time+PCR+method&rft.au=Bjornsdottir-Butler%2C+Kristin%3BJones%2C+Jessica+L%3BBenner%2C+Ronald+A%3BBurkhardt%2C+William&rft.aulast=Bjornsdottir-Butler&rft.aufirst=Kristin&rft.date=2011-10-01&rft.volume=28&rft.issue=7&rft.spage=1284&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2011.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Marine fish; Nucleotide sequence; Fish poisoning; Microbiology; DNA; Polymerase chain reaction; Histamines; Pollution control; Most probable number; Colony-forming cells; Poisoning; Microflora; Histamine; Photobacterium damselae; Coryphaena hippurus; Thunnus albacares; Scomberomorus maculates; Scomber; Morganella morganii; Raoultella planticola; Enterobacter aerogenes; Marine DO - http://dx.doi.org/10.1016/j.fm.2011.05.006 ER - TY - JOUR T1 - The evolution of skin notations for occupational risk assessment: a new NIOSH strategy. AN - 888089892; 21689711 AB - This article presents an overview of a strategy for assignment of hazard-specific skin notations (SK), developed by the National Institute for Occupational Safety and Health (NIOSH). This health hazard characterization strategy relies on multiple SKs capable of delineating systemic (SYS), direct (DIR), and immune-mediated (SEN) adverse effects caused by dermal exposures to chemicals. One advantage of the NIOSH strategy is the ability to combine SKs when it is determined that a chemical may cause multiple adverse effects following dermal contact (e.g., SK: SYS-DIR-SEN). Assignment of the SKs is based on a weight-of-evidence (WOE) approach, which refers to the critical examination of all available data from diverse lines of evidence and the derivation of a scientific interpretation based on the collective body of data including its relevance, quality, and reported results. Numeric cutoff values, based on indices of toxic potency, serve as guidelines to aid in consistently determining a chemical's relative toxicity and hazard potential. The NIOSH strategy documents the scientific rationale for determination of the hazard potential of a chemical and the subsequent assignment of SKs. A case study of acrylamide is presented as an application of the NIOSH strategy. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Dotson, G Scott AU - Chen, Chen-Peng AU - Gadagbui, Bernard AU - Maier, Andrew AU - Ahlers, Heinz W AU - Lentz, Thomas J AD - Education and Information Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45227, USA. fya8@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 53 EP - 62 VL - 61 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Risk KW - Animals KW - Humans KW - Male KW - Female KW - Occupational Exposure KW - Hazardous Substances -- classification KW - Skin -- drug effects KW - Skin -- metabolism KW - Hazardous Substances -- pharmacokinetics KW - Skin Diseases -- metabolism KW - Skin Diseases -- mortality KW - National Institute for Occupational Safety and Health (U.S.) -- standards KW - Skin Diseases -- pathology KW - Skin Diseases -- chemically induced KW - Risk Assessment -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888089892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+evolution+of+skin+notations+for+occupational+risk+assessment%3A+a+new+NIOSH+strategy.&rft.au=Dotson%2C+G+Scott%3BChen%2C+Chen-Peng%3BGadagbui%2C+Bernard%3BMaier%2C+Andrew%3BAhlers%2C+Heinz+W%3BLentz%2C+Thomas+J&rft.aulast=Dotson&rft.aufirst=G&rft.date=2011-10-01&rft.volume=61&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2011.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-06 N1 - Date created - 2011-09-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2011.06.002 ER - TY - JOUR T1 - Benzocaine-induced methemoglobinemia in an acute-exposure rat model. AN - 885563987; 21726594 AB - Tricaine methanesulfonate, a sedative for temporarily immobilizing fish, has a 21-day withdrawal time. Benzocaine has been proposed as an alternative sedative because a withdrawal period may not be required. Since benzocaine is known to induce methemoglobinemia, the potential for orally administered benzocaine to induce methemoglobin was assessed in rats. Sprague-Dawley rats were given a single gavage administration of 64mg benzocaine hydrochloride per kg bw and then euthanized at intervals up to 120min. Plasma levels of benzocaine were relatively low at all times, whereas methemoglobin peaked at 24min. Additional rats were orally gavaged with 0-1024mg benzocaine hydrochloride per kg bw and euthanized after 24min. Plasma levels of benzocaine increased from 0.01μM at 2mg per kg bw to 2.9μM at 1024mg per kg bw. Methemoglobin levels did not differ from controls at doses up to 32mg per kg bw in females and 64mg per kg bw in males, whereupon the value increased to ∼80% at 1024mg per kg bw. These data were used to estimate the potential impact of benzocaine residues in fish and suggest that the consumption of fish treated with benzocaine hydrochloride will not cause methemoglobinemia in humans. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Von Tungeln, Linda S AU - Zhou, Tong AU - Woodling, Kellie A AU - Doerge, Daniel R AU - Greenlees, Kevin J AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 2530 EP - 2535 VL - 49 IS - 10 KW - Anesthetics, Local KW - 0 KW - Methemoglobin KW - 9008-37-1 KW - Benzocaine KW - U3RSY48JW5 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Linear Models KW - Male KW - Female KW - Anesthetics, Local -- blood KW - Methemoglobin -- metabolism KW - Methemoglobinemia -- chemically induced KW - Methemoglobinemia -- blood KW - Anesthetics, Local -- toxicity KW - Benzocaine -- toxicity KW - Benzocaine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885563987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Benzocaine-induced+methemoglobinemia+in+an+acute-exposure+rat+model.&rft.au=Von+Tungeln%2C+Linda+S%3BZhou%2C+Tong%3BWoodling%2C+Kellie+A%3BDoerge%2C+Daniel+R%3BGreenlees%2C+Kevin+J%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2011-10-01&rft.volume=49&rft.issue=10&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2011.06.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-02-22 N1 - Date created - 2011-08-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2011.06.048 ER - TY - JOUR T1 - Cellular glutathione in fatty liver in vitro models. AN - 885560475; 21620948 AB - The range of non-alcoholic fatty liver disease (NAFLD) includes simple hepatic steatosis, the inflammatory non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. The accumulation of specific lipids in hepatocytes has been associated with oxidative stress and progression of the disease. Elevated serum free fatty acids and hepatocyte lipotoxicity can be studied in an in vitro cellular model. For this purpose, we cultured the human liver cell line, HepG2/C3A, in medium supplemented with increasing amounts of oleic acid (C18:1) and evaluated oxidative stress by measuring the content of the cellular antioxidant, glutathione (GSH). We observed a dose-dependent steatosis, as determined by Nile Red staining, with concurrent increases of GSH; similar findings were also observed in cultured human hepatocytes. Cells cultured with palmitic acid (C16:0) or the combination oleic/palmitic acids (2:1 ratio) also exhibited a dose-dependent increase of GSH; however palmitic-supplemented cultures did not sustain the GSH increase after 24h. We also detected an increase in the formation of lipid peroxides (LPO) indicating that the increase of GSH was a cellular mechanism that may be related to the high exposure of fatty acids. The results of this in vitro study suggest an antioxidant response against fat overloading and indicate potential differences in response to specific fatty acid-induced hepatic steatosis and associated lipotoxicity. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Garcia, Martha C AU - Amankwa-Sakyi, Margaret AU - Flynn, Thomas J AD - FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States. martha.garcia@fda.hhs.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1501 EP - 1506 VL - 25 IS - 7 KW - Lipid Peroxides KW - 0 KW - Oleic Acid KW - 2UMI9U37CP KW - Palmitic Acid KW - 2V16EO95H1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Hep G2 Cells KW - Dose-Response Relationship, Drug KW - Humans KW - Oxidative Stress -- drug effects KW - Middle Aged KW - Lipid Peroxides -- metabolism KW - Models, Biological KW - Lipid Peroxidation KW - Male KW - Female KW - Palmitic Acid -- administration & dosage KW - Hepatocytes -- drug effects KW - Fatty Liver -- chemically induced KW - Fatty Liver -- metabolism KW - Oleic Acid -- administration & dosage KW - Glutathione -- metabolism KW - Palmitic Acid -- toxicity KW - Fatty Liver -- pathology KW - Oleic Acid -- toxicity KW - Hepatocytes -- pathology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/885560475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Cellular+glutathione+in+fatty+liver+in+vitro+models.&rft.au=Garcia%2C+Martha+C%3BAmankwa-Sakyi%2C+Margaret%3BFlynn%2C+Thomas+J&rft.aulast=Garcia&rft.aufirst=Martha&rft.date=2011-10-01&rft.volume=25&rft.issue=7&rft.spage=1501&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2011.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-04-26 N1 - Date created - 2011-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tiv.2011.05.011 ER - TY - JOUR T1 - Determination of Levamisole in Urine by Gas Chromatography-Mass Spectrometry AN - 1093456986; 17185803 AB - The United States Public Health Service Substance Abuse and Mental Health Services Administration is alerting medical professionals that a substantial percentage of cocaine imported into the United States is adulterated with levamisole, a veterinary pharmaceutical that can cause blood cell disorders such as severe neutropenia and agranulocytosis. Levamisole HCl is the active ingredient in a number of veterinary drugs approved to treat worm infestations in animals. Levamisole HCl was also the active ingredient in a human drug for oral administration approved on June 18, 1990, as adjuvant treatment in combination with fluorouracil after surgical resection in patients with Duke's stage C colon cancer. This drug was withdrawn from the U.S. market around 2000, and it has not been marketed in the U.S. since then. The objective of this study was to develop a method to determine the amount of levamisole in urine samples. The procedure will be provided to state health laboratories as needed to be used in the evaluation of patients that have developed neutropenia or agranulocytosis in the setting of recent cocaine use. A gas chromatography-mass spectrometry method was validated and tested at two different laboratories, and the method limit of detection for levamisole is 1 ng/mL in urine when using a 5-mL sample. Confirmation of the stereoisomer of levamisole was done by high-performance liquid chromatography using a chiral column. JF - Journal of Analytical Toxicology AU - Trehy, Michael L AU - Brown, Daniel J AU - Woodruff, Jeffrey T AU - Westenberger, Benjamin J AU - Nychis, William G AU - Reuter, Nicholas AU - Schier, Joshua G AU - Vagi, Sara J AU - Hwang, Rong-Jen AD - U.S. FDA/CDER/DPA, 1114 Market Street, St. Louis, Missouri 63101, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 545 EP - 550 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 35 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Adjuvants KW - Blood cells KW - Cocaine KW - Colon cancer KW - Drug abuse KW - Gas chromatography KW - High-performance liquid chromatography KW - Infestation KW - Mass spectroscopy KW - Mental disorders KW - Neutropenia KW - Oral administration KW - Pharmaceuticals KW - Public health KW - Stereoisomers KW - Urine KW - levamisole KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093456986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Determination+of+Levamisole+in+Urine+by+Gas+Chromatography-Mass+Spectrometry&rft.au=Trehy%2C+Michael+L%3BBrown%2C+Daniel+J%3BWoodruff%2C+Jeffrey+T%3BWestenberger%2C+Benjamin+J%3BNychis%2C+William+G%3BReuter%2C+Nicholas%3BSchier%2C+Joshua+G%3BVagi%2C+Sara+J%3BHwang%2C+Rong-Jen&rft.aulast=Trehy&rft.aufirst=Michael&rft.date=2011-10-01&rft.volume=35&rft.issue=8&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/2011/00000035/00000008/art00003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-10-19 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Oral administration; Stereoisomers; Adjuvants; Colon cancer; Drug abuse; Mass spectroscopy; Public health; Neutropenia; Mental disorders; Infestation; Urine; Gas chromatography; Pharmaceuticals; Blood cells; Cocaine; levamisole ER - TY - JOUR T1 - Practical considerations for the rapid screening for pesticides using ambient pressure desorption ionisation with high-resolution mass spectrometry AN - 1038597923; 17045468 AB - A rapid screening method for pesticides has been developed to streamline the processing of produce entering the United States. Foam swabs were used to recover multi-class mixtures of 240, 140, 132 and 60 pesticides from the surfaces of apples, kiwis, peaches and tomatoes. The mixtures were selected to span a large range of chemical classes, polarities, solubilities and sizes to provide a broad look at how this technique will perform for a variety of analytes. The swabs were analysed using direct analysis in real-time (DART) ionisation coupled with a high-resolution Exactive Orbitrap(TM) mass spectrometer. This study expands the types of commodities analysed using this method and explores the feasibility of compositing multiple units of produce per batch to analyse a representative sample. It was established that whilst smooth-skinned produce, such as apples, maintained a high detection rate for the pesticide mixtures even when ten apples are swabbed with one foam disk, commodities with rougher surfaces, such as peaches, suffered a decrease in detection rate when ten peaches are swabbed with one foam disk. In order to maintain some consistency across the sample preparation process, a composite size of three units was selected. The varying topography of the commodities necessitated minor modifications to the method; for example, analysis of kiwi required that the hair on the surface be shaved prior to swabbing to achieve good recovery. Additionally, the effect of storage conditions on detection rate was analysed by spiking the surface of tomatoes at levels of 5 and 10 ng g-1 for each pesticide, storing them under refrigeration and ambient conditions for 3 and 8 days, and then analysing the surface using this method. After 8 days of storage under both conditions more than 80% of the pesticides in the mixture were detected. Also, analysis of the multi-class mixtures was performed in both positive- and negative-ion mode and many classes were detected in both modes. Some classes, such thiocarbamates, phenylamides and organochlorine pesticides, were only observed in the positive-ion mode, whilst benzoylphenylurea pesticides were only detected in the negative-ion mode. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Edison, SE AU - Lin, LA AU - Parrales, L AD - US Food and Drug Administration, Forensic Chemistry Center, Cincinnati, OH 45237, USA Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1393 EP - 1404 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 28 IS - 10 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Desorption KW - Feasibility studies KW - Food additives KW - Mass spectrometry KW - Organochlorine pesticides KW - Pesticides KW - Risk assessment KW - Storage KW - Topography KW - Prunus KW - Lycopersicon esculentum KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038597923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Practical+considerations+for+the+rapid+screening+for+pesticides+using+ambient+pressure+desorption+ionisation+with+high-resolution+mass+spectrometry&rft.au=Edison%2C+SE%3BLin%2C+LA%3BParrales%2C+L&rft.aulast=Edison&rft.aufirst=SE&rft.date=2011-10-01&rft.volume=28&rft.issue=10&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2011.596165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2012-10-08 N1 - SubjectsTermNotLitGenreText - Feasibility studies; Risk assessment; Storage; Food additives; Desorption; Organochlorine pesticides; Pesticides; Mass spectrometry; Topography; Lycopersicon esculentum; Prunus; USA DO - http://dx.doi.org/10.1080/19440049.2011.596165 ER - TY - JOUR T1 - Reducing Racial And Ethnic Disparities: The Action Plan From The Department Of Health And Human Services AN - 1030869755; 201205330 AB - The Department of Health and Human Services (HHS) recently unveiled the most comprehensive federal commitment yet to reducing racial and ethnic health disparities. The 2011 HHS Action Plan to Reduce Racial and Ethnic Health Disparities not only responds to advice previously offered by stakeholders around the nation, but it also capitalizes on new and unprecedented opportunities in the Affordable Care Act of 2010 to benefit diverse communities. The Action Plan advances five major goals: transforming health care; strengthening the infrastructure and workforce of the nation's health and human services; advancing Americans' health and well-being; promoting scientific knowledge and innovation; and upholding the accountability of HHS for making demonstrable progress. By mobilizing HHS around these goals, the Action Plan moves the country closer to realizing the vision of a nation free of disparities in health and health care. Adapted from the source document. JF - Health Affairs AU - Koh, Howard K AU - Graham, Garth AU - Glied, Sherry A AD - Department of Health and Human Services (HHS), in Washington, D.C Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 1822 EP - 1829 PB - Project HOPE, Bethesda MD VL - 30 IS - 10 SN - 0278-2715, 0278-2715 KW - Human Services KW - Well Being KW - Scientific Knowledge KW - Interest Groups KW - Innovations KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1030869755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Reducing+Racial+And+Ethnic+Disparities%3A+The+Action+Plan+From+The+Department+Of+Health+And+Human+Services&rft.au=Koh%2C+Howard+K%3BGraham%2C+Garth%3BGlied%2C+Sherry+A&rft.aulast=Koh&rft.aufirst=Howard&rft.date=2011-10-01&rft.volume=30&rft.issue=10&rft.spage=1822&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2011.0673 LA - English DB - Social Services Abstracts N1 - Date revised - 2012-08-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Care Services; Human Services; Innovations; Well Being; Interest Groups; Scientific Knowledge DO - http://dx.doi.org/10.1377/hlthaff.2011.0673 ER - TY - JOUR T1 - A multicenter study on the audiometric findings of styrene-exposed workers AN - 1023095882; 201216859 AB - Objective: The objective of this study was to evaluate hearing loss among workers exposed to styrene, alone or with noise. Design: This cross-sectional study was conducted as part of NoiseChem, a European Commission 5th Framework Programme research project, by occupational health institutes in Finland, Sweden, and Poland. Study sample: Participants' ages ranged from 18-72 years (n = 1620 workers). Participants exposed to styrene, alone or with noise, were from reinforced fiberglass products manufacturing plants (n = 862). Comparison groups were comprised of workers noise-exposed (n = 400) or controls (n = 358). Current styrene exposures ranged from 0 to 309 mg/m3, while mean current noise levels ranged from 70-84 dB(A). Hearing thresholds of styrene-exposed participants were compared with Annexes A and B from ANSI S3.44, 1996. Results: The audiometric thresholds of styrene exposed workers were significantly poorer than those in published standards. Age, gender, and styrene exposure met the significance level criterion in the multiple logistic regression for the binary outcome 'hearing loss' (P = 0.0000). Exposure to noise (<85 dBA p = 0.0001; =85 dB(A) p = 0.0192) interacted significantly with styrene exposure. Conclusions: Occupational exposure to styrene is a risk factor for hearing loss, and styrene-exposed workers should be included in hearing loss prevention programs. Adapted from the source document. JF - International Journal of Audiology AU - Morata, Thais C AU - Sliwinska-Kowalska, Mariola AU - Johnson, Ann-Christin AU - Starck, Jukka AU - Pawlas, Krystyna AU - Zamyslowska-Szmytke, Ewa AU - Nylen, Per AU - Toppila, Esko AU - Krieg, Edward AU - Pawlas, Natalia AU - Prasher, Deepak AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health tmorata@cdc.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 652 EP - 660 PB - Informa Healthcare, Taylor and Francis, London UK VL - 50 IS - 10 SN - 1499-2027, 1499-2027 KW - Pure-tone audiometry, Otologically unscreened, Noise, Hearing loss KW - Cross-sectional studies KW - Noise KW - Hearing KW - Hearing impairment KW - Occupational exposure KW - Thresholds KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1023095882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=A+multicenter+study+on+the+audiometric+findings+of+styrene-exposed+workers&rft.au=Morata%2C+Thais+C%3BSliwinska-Kowalska%2C+Mariola%3BJohnson%2C+Ann-Christin%3BStarck%2C+Jukka%3BPawlas%2C+Krystyna%3BZamyslowska-Szmytke%2C+Ewa%3BNylen%2C+Per%3BToppila%2C+Esko%3BKrieg%2C+Edward%3BPawlas%2C+Natalia%3BPrasher%2C+Deepak&rft.aulast=Morata&rft.aufirst=Thais&rft.date=2011-10-01&rft.volume=50&rft.issue=10&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2011.588965 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Noise; Hearing impairment; Thresholds; Hearing; Cross-sectional studies; Occupational exposure DO - http://dx.doi.org/10.3109/14992027.2011.588965 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIETHYLAMINE (CAS No. 109-89-7) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) AN - 1018529564; 22127322 AB - Diethylamine is used in the production of a corrosion inhibitor and also of pesticides, insect repellants and rubber products. Diethylamine vapors are strong irritants to the eyes, nose, and throat of workers. We studied long-term exposure of lower concentrations of diethylamine to rats and mice to see if it caused cancer or other toxic effects. We exposed groups of 50 male and female rats to atmospheres containing 31, 62.5, or 125 parts per million (ppm) of diethylamine. We also exposed groups of 50 male and female mice to atmospheres containing 16, 31, or 62.5 ppm diethylamine. Similar groups of 50 animals were exposed only to clean air in the same exposure chambers and served as the control groups. Animals were exposed 6 hours per day, 5 days per week for 2 years. Tissues from more than 40 sites were examined for every animal. The nose was the main site of injury for all groups of rats and mice exposed to diethylamine. A variety of lesions were observed in the nasal cavity, including atrophy, hyperplasia and metaplasia of the olfactory epithelium in rats and mice and hyperplasia and metaplasia of the respiratory epithelium in rats and squamous metaplasia of the respiratory epithelium in mice. Inflammation of the cornea was observed in some exposed male rats, and inflammation of the pleura and lung were observed in exposed female rats. We conclude that exposure to diethylamine caused a spectrum of inflammatory lesions in the nose of male and female rats and mice and lesions in the eye of male rats and pleura and lung of female rats. There was no evidence that diethylamine caused any cancers in these studies. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1 EP - 174 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Diethylamines KW - Environmental Pollutants KW - Mutagens KW - diethylamine KW - Carcinogens KW - Toxicology KW - Rodents KW - Studies KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Nose Diseases -- chemically induced KW - Escherichia coli -- genetics KW - Salmonella typhimurium -- drug effects KW - Rats KW - Rats, Inbred F344 KW - Lung Diseases -- chemically induced KW - Escherichia coli -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Nose Diseases -- pathology KW - Corneal Diseases -- pathology KW - Salmonella typhimurium -- genetics KW - Male KW - Inflammation -- pathology KW - Corneal Diseases -- chemically induced KW - Pleural Diseases -- pathology KW - Lung Diseases -- pathology KW - Mutagens -- toxicity KW - Mice KW - Mice, Inbred Strains KW - Mutagenicity Tests KW - Pleural Diseases -- chemically induced KW - Neoplasms -- pathology KW - Inhalation Exposure KW - Carcinogenicity Tests KW - Female KW - Environmental Pollutants -- toxicity KW - Neoplasms -- chemically induced KW - Inflammation -- chemically induced KW - Diethylamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+DIETHYLAMINE+%28CAS+No.+109-89-7%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 1018529559 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 1018529549 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018529549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2011-10-01&rft.volume=&rft.issue=566&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2011 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Unpacking the Blockers: Understanding Perceptions and Social Constraints of Health Communication in Hereditary Breast Ovarian Cancer (HBOC) Susceptibility Families AN - 1018378131; 201211580 AB - Family communication is essential for accurate cancer risk assessment and counseling; family blockers play a role in this communication process. This qualitative analysis of social exchanges is an extension of earlier work characterizing those who are perceived by study participants as health information gatherers, disseminators, and blockers within families with Hereditary Breast and Ovarian Cancer (HBOC) susceptibility. Eighty-nine women, ages 23-56 years, enrolled in a Breast Imaging Study (BIS) and participated in a sub-study utilizing a social assessment tool known as the Colored Ecological Genetic Relational Map (CEGRM). Purposive sampling ensured that participants varied according to numbers of participating family members e.g., ranging from 1 to 6. Eighty-nine women from 42 families (1-8 relatives/family) participated. They collectively designated 65 blockers, both male and female. Situational factors, beliefs, attitudes and cultural traditions, privacy and protectiveness comprised perceived reasons for blocking intra-family health communications. Longitudinal data collected over 4 years showed families where blocking behavior was universally recognized and stable over time, as well as other families where blocking was less consistent. Self-blocking was observed among a significant minority of participating women. Blocking of health communications among family members with HBOC was variable, complex, and multifaceted. The reasons for blocking were heterogeneous; duration of the blocking appeared to depend on the reasons for blocking. Blocking often seemed to involve bi-directional feedback loops, in keeping with Lepore's Social Constraints and Modulation Theory. Privacy and protectiveness predominated as explanations for long-term blocking. Adapted from the source document. JF - Journal of Genetic Counseling AU - Peters, June A AU - Kenen, Regina AU - Hoskins, Lindsey M AU - Koehly, Laura M AU - Graubard, Barry AU - Loud, Jennifer T AU - Greene, Mark H AD - Clinical Genetics Branch (CGB), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 6120 Executive Blvd, Rockville, MD, 20852, USA petersju@mail.nih.gov Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 450 EP - 464 PB - Springer Science+Business Media, New York NY VL - 20 IS - 5 SN - 1059-7700, 1059-7700 KW - Ovarian cancer KW - Blocking KW - Women KW - Health KW - Relatives KW - Susceptibility KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018378131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Unpacking+the+Blockers%3A+Understanding+Perceptions+and+Social+Constraints+of+Health+Communication+in+Hereditary+Breast+Ovarian+Cancer+%28HBOC%29+Susceptibility+Families&rft.au=Peters%2C+June+A%3BKenen%2C+Regina%3BHoskins%2C+Lindsey+M%3BKoehly%2C+Laura+M%3BGraubard%2C+Barry%3BLoud%2C+Jennifer+T%3BGreene%2C+Mark+H&rft.aulast=Peters&rft.aufirst=June&rft.date=2011-10-01&rft.volume=20&rft.issue=5&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-011-9370-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Blocking; Relatives; Women; Ovarian cancer; Health; Susceptibility DO - http://dx.doi.org/10.1007/s10897-011-9370-0 ER - TY - JOUR T1 - Coal dust exposure and mortality from ischemic heart disease among a cohort of U.S. coal miners AN - 1017960268; 16691512 AB - Background Particulate exposure from air pollution increases the risk of ischemic heart disease (IHD) mortality. Although coal miners are highly exposed to coal dust particulate, studies of IHD mortality risk among coal miners have had inconsistent results. Previous studies may have been biased by the healthy worker effect. Methods We examined the dose-response relationship between cumulative coal dust exposure, coal rank, and IHD mortality among a cohort of underground coal miners who participated in the National Study of Coal Workers' Pneumoconiosis. Results After adjusting for age, smoking, and body mass index, risk of IHD mortality increased at higher levels of coal dust exposure. Mortality risk was also associated with coal rank region. Conclusion There was an increased risk of mortality from IHD associated with cumulative exposure to coal dust, and with coal rank. The effect of coal rank may be due differences in the composition of coal mine dust particulate. The association of risk of IHD mortality with cumulative particulate exposure is consistent with air pollution studies. Am. J. Ind. Med. 54:727-733, 2011. ? 2011 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Landen, Deborah D AU - Wassell, James T AU - McWilliams, Linda AU - Patel, Ami AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, dlanden@cdc.gov Y1 - 2011/10// PY - 2011 DA - Oct 2011 SP - 727 EP - 733 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 10 SN - 1097-0274, 1097-0274 KW - Pollution Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Occupational safety KW - Pneumoconiosis KW - Particulates KW - Coal KW - heart diseases KW - Dust KW - Workers KW - Smoking KW - Dose-response effects KW - Occupational exposure KW - Heart diseases KW - Mortality KW - Ischemia KW - Mines KW - Air pollution KW - USA KW - Coal dust KW - Mining KW - Body mass index KW - X 24380:Social Poisons & Drug Abuse KW - P 0000:AIR POLLUTION KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017960268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Coal+dust+exposure+and+mortality+from+ischemic+heart+disease+among+a+cohort+of+U.S.+coal+miners&rft.au=Landen%2C+Deborah+D%3BWassell%2C+James+T%3BMcWilliams%2C+Linda%3BPatel%2C+Ami&rft.aulast=Landen&rft.aufirst=Deborah&rft.date=2011-10-01&rft.volume=54&rft.issue=10&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20986 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20986/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Pneumoconiosis; Coal; Ischemia; Mines; Dust; Air pollution; Smoking; Workers; Dose-response effects; Coal dust; Body mass index; Occupational exposure; Heart diseases; Occupational safety; Mining; Particulates; heart diseases; USA DO - http://dx.doi.org/10.1002/ajim.20986 ER - TY - JOUR T1 - Temporal Patterns in Work-Related Fatalities Among Foreign-Born Workers in the US, 1992-2007 AN - 1010707564; 201209010 AB - In the United States, approximately 20% of all workers who died on the job in 2007 were foreign-born. The objective of this study was to describe trends in occupational fatalities among foreign-born workers. An analysis of fatal injuries among foreign-born workers in the US occurring from 1992 through 2007 was conducted using the Bureau of Labor Statistics' Census of Fatal Occupational Injuries. Individual characteristics, employment characteristics, injury events and industry employment were summarized and evaluated for trends. Both the number and proportion of foreign-born workers who died from a traumatic work-related injury increased substantially over the time period studied. The proportion who were men, aged 25-44 years, Hispanic, non self-employed, employed by business establishments with 10 or fewer employees, working at private residences and working in Construction and Services consistently increased throughout the time period. While some trends among foreign-born decedents are improving, others are worsening. More comprehensive research efforts are needed to address the occupational injury and safety issues among foreign-born workers, with a focus on Hispanics. Adapted from the source document. JF - Journal of Immigrant and Minority Health AU - Menendez, Cammie K. Chaumont AU - Havea, Solomone A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS-1811, Morgantown, WV, 26505, USA Y1 - 2011/10// PY - 2011 DA - October 2011 SP - 954 EP - 962 PB - Springer, Dordrecht The Netherlands VL - 13 IS - 5 SN - 1557-1912, 1557-1912 KW - Men KW - Industrial accidents KW - Safety KW - Hispanic people KW - Temporal patterns KW - Employment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1010707564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Temporal+Patterns+in+Work-Related+Fatalities+Among+Foreign-Born+Workers+in+the+US%2C+1992-2007&rft.au=Menendez%2C+Cammie+K.+Chaumont%3BHavea%2C+Solomone+A&rft.aulast=Menendez&rft.aufirst=Cammie+K.&rft.date=2011-10-01&rft.volume=13&rft.issue=5&rft.spage=954&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-010-9379-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Industrial accidents; Employment; Hispanic people; Safety; Temporal patterns; Men DO - http://dx.doi.org/10.1007/s10903-010-9379-8 ER - TY - JOUR T1 - Comparing next-generation sequencing and microarray technologies in a toxicological study of the effects of aristolochic acid on rat kidneys. AN - 893271870; 21834575 AB - RNA-Seq has been increasingly used for the quantification and characterization of transcriptomes. The ongoing development of the technology promises the more accurate measurement of gene expression. However, its benefits over widely accepted microarray technologies have not been adequately assessed, especially in toxicogenomics studies. The goal of this study is to enhance the scientific community's understanding of the advantages and challenges of RNA-Seq in the quantification of gene expression by comparing analysis results from RNA-Seq and microarray data on a toxicogenomics study. A typical toxicogenomics study design was used to compare the performance of an RNA-Seq approach (Illumina Genome Analyzer II) to a microarray-based approach (Affymetrix Rat Genome 230 2.0 arrays) for detecting differentially expressed genes (DEGs) in the kidneys of rats treated with aristolochic acid (AA), a carcinogenic and nephrotoxic chemical most notably used for weight loss. We studied the comparability of the RNA-Seq and microarray data in terms of absolute gene expression, gene expression patterns, differentially expressed genes, and biological interpretation. We found that RNA-Seq was more sensitive in detecting genes with low expression levels, while similar gene expression patterns were observed for both platforms. Moreover, although the overlap of the DEGs was only 40-50%, the biological interpretation was largely consistent between the RNA-Seq and microarray data. RNA-Seq maintained a consistent biological interpretation with time-tested microarray platforms while generating more sensitive results. However, there is clearly a need for future investigations to better understand the advantages and limitations of RNA-Seq in toxicogenomics studies and environmental health research. JF - Chemical research in toxicology AU - Su, Zhenqiang AU - Li, Zhiguang AU - Chen, Tao AU - Li, Quan-Zhen AU - Fang, Hong AU - Ding, Don AU - Ge, Weigong AU - Ning, Baitang AU - Hong, Huixiao AU - Perkins, Roger G AU - Tong, Weida AU - Shi, Leming AD - ICF International at FDA's National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. zhenqiang.su@fda.hhs.gov Y1 - 2011/09/19/ PY - 2011 DA - 2011 Sep 19 SP - 1486 EP - 1493 VL - 24 IS - 9 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - Index Medicus KW - Rats KW - Animals KW - Carcinogenicity Tests -- methods KW - Gene Expression Regulation -- drug effects KW - Toxicogenetics -- methods KW - Kidney -- metabolism KW - Aristolochic Acids -- toxicity KW - Oligonucleotide Array Sequence Analysis -- methods KW - Kidney -- drug effects KW - Carcinogens -- toxicity KW - Sequence Analysis, RNA -- methods KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/893271870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Comparing+next-generation+sequencing+and+microarray+technologies+in+a+toxicological+study+of+the+effects+of+aristolochic+acid+on+rat+kidneys.&rft.au=Su%2C+Zhenqiang%3BLi%2C+Zhiguang%3BChen%2C+Tao%3BLi%2C+Quan-Zhen%3BFang%2C+Hong%3BDing%2C+Don%3BGe%2C+Weigong%3BNing%2C+Baitang%3BHong%2C+Huixiao%3BPerkins%2C+Roger+G%3BTong%2C+Weida%3BShi%2C+Leming&rft.aulast=Su&rft.aufirst=Zhenqiang&rft.date=2011-09-19&rft.volume=24&rft.issue=9&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx200103b LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2012-01-18 N1 - Date created - 2011-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx200103b ER - TY - CPAPER T1 - Antibacterial Activity of a Novel Peptide Derived from Phage-Displayed Random Peptide Library T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313050994; 6111081 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Sainath Rao, S. AU - Mohan, K AU - Atreya, C Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Peptide libraries KW - Antibacterial activity KW - Peptides KW - Antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313050994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Antibacterial+Activity+of+a+Novel+Peptide+Derived+from+Phage-Displayed+Random+Peptide+Library&rft.au=Sainath+Rao%2C+S.%3BMohan%2C+K%3BAtreya%2C+C&rft.aulast=Sainath+Rao&rft.aufirst=S.&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Analysis of an Increase in All-Cause Mortality in Tigecycline Treated Patients T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313016625; 6111130 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Iarikov, D AU - Alexander, J AU - Charles, J AU - Tracy, L AU - Nambiar, S Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Mortality KW - tigecycline UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313016625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Analysis+of+an+Increase+in+All-Cause+Mortality+in+Tigecycline+Treated+Patients&rft.au=Iarikov%2C+D%3BAlexander%2C+J%3BCharles%2C+J%3BTracy%2C+L%3BNambiar%2C+S&rft.aulast=Iarikov&rft.aufirst=D&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Enhanced Antimicrobicidal Activity of Peptide-Cocktails against Bacterial Contaminants in Stored Platelets T2 - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AN - 1313015183; 6111083 JF - 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2012) AU - Mohan, K AU - Sainath Rao, S. AU - Atreya, C Y1 - 2011/09/17/ PY - 2011 DA - 2011 Sep 17 KW - Contaminants KW - Platelets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.atitle=Enhanced+Antimicrobicidal+Activity+of+Peptide-Cocktails+against+Bacterial+Contaminants+in+Stored+Platelets&rft.au=Mohan%2C+K%3BSainath+Rao%2C+S.%3BAtreya%2C+C&rft.aulast=Mohan&rft.aufirst=K&rft.date=2011-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2012%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/images/icaac2011_program_web.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague-Dawley rats AN - 902377424; 15618173 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA metabolites in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure in the range of 0.02-0.2 mu g/kgbw/d (25th-95th percentiles). The current study used LC/MS/MS to measure placental transfer and concentrations of aglycone (receptor-active) and conjugated (inactive) BPA in tissues from Sprague-Dawley rats administered deuterated BPA (100 mu g/kg bw) by oral and IV routes. In adult female rat tissues, the tissue/serum concentration ratios for aglycone BPA ranged from 0.7 in liver to 5 in adipose tissue, reflecting differences in tissue perfusion, composition, and metabolic capacity. Following IV administration to dams, placental transfer was observed for aglycone BPA into fetuses at several gestational days (GD), with fetal/maternal serum ratios of 2.7 at GD 12, 1.2 at GD 16, and 0.4 at GD 20; the corresponding ratios for conjugated BPA were 0.43, 0.65, and 3.7. These ratios were within the ranges observed in adult tissues and were not indicative of preferential accumulation of aglycone BPA or hydrolysis of conjugates in fetal tissue in vivo. Concentrations of aglycone BPA in GD 20 fetal brain were higher than in liver or serum. Oral administration of the same dose did not produce measurable levels of aglycone BPA in fetal tissues. Amniotic fluid consistently contained levels of BPA at or below those in maternal serum. Concentrations of aglycone BPA in tissues of neonatal rats decreased with age in a manner consistent with the corresponding circulating levels. Phase II metabolism of BPA increased with fetal age such that near-term fetus was similar to early post-natal rats. These results show that concentrations of aglycone BPA in fetal tissues are similar to those in other maternal and neonatal tissues and that maternal Phase II metabolism, especially following oral administration, and fetal age are critical in reducing exposures to the fetus. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Brown, Ronald P AU - Fisher, Jeffrey W Y1 - 2011/09/15/ PY - 2011 DA - 2011 Sep 15 SP - 261 EP - 270 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 255 IS - 3 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Amniotic fluid KW - Age KW - Aglycones KW - Perfusion KW - Food KW - Oral administration KW - Brain KW - Metabolites KW - Plasticity KW - Hydrolysis KW - Fetuses KW - Bisphenol A KW - Placental transfer KW - Urine KW - Liver KW - Adipose tissue KW - Neonates KW - Metabolism KW - polycarbonate KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902377424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Distribution+of+bisphenol+A+into+tissues+of+adult%2C+neonatal%2C+and+fetal+Sprague-Dawley+rats&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BBrown%2C+Ronald+P%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2011-09-15&rft.volume=255&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2011.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Aglycones; Age; Perfusion; Food; Brain; Oral administration; Metabolites; Plasticity; Hydrolysis; Fetuses; Bisphenol A; Urine; Placental transfer; Liver; Adipose tissue; Neonates; polycarbonate; Metabolism DO - http://dx.doi.org/10.1016/j.taap.2011.07.009 ER - TY - JOUR T1 - Photoirradiation of dehydropyrrolizidine alkaloids--formation of reactive oxygen species and induction of lipid peroxidation. AN - 880998447; 21723383 AB - Pyrrolizidine alkaloid (PA)-containing plants are widespread in the world and are probably the most common poisonous plants affecting livestock, wildlife, and human. PAs require metabolic activation to generate pyrrolic metabolites (dehydro-PAs) that bind cellular protein and DNA, leading to hepatotoxicity and genotoxicity, including tumorigenicity. In this study we report that UVA photoirradiation of a series of dehydro-PAs, e.g., dehydromonocrotaline, dehydroriddelliine, dehydroretrorsine, dehydrosenecionine, dehydroseneciphylline, dehydrolasiocarpine, dehydroheliotrine, and dehydroretronecine (DHR) at 0-70 J/cm2 in the presence of a lipid, methyl linoleate, resulted in lipid peroxidation in a light dose-responsive manner. When irradiated in the presence of sodium azide, the level of lipid peroxidation decreased; lipid peroxidation was enhanced when methanol was replaced by deuterated methanol. These results suggest that singlet oxygen is a photo-induced product. When irradiated in the presence of superoxide dismutase, the level of lipid peroxidation decreased, indicating that lipid peroxidation is also mediated by superoxide. Electron spin resonance (ESR) spin trapping studies confirmed that both singlet oxygen and superoxide anion radical were formed during photoirradiation. These results indicate that UVA photoirradiation of dehydro-PAs generates reactive oxygen species (ROS) that mediated the initiation of lipid peroxidation. UVA irradiation of the parent PAs and other PA metabolites, including PA N-oxides, under similar experimental conditions did not produce lipid peroxidation. It is known that PAs induce skin cancer and are secondary (hepatogenous) photosensitization agents. Our results suggest that dehydro-PAs are the active metabolites responsible for skin cancer formation and PA-induced secondary photosensitization. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Zhao, Yuewei AU - Xia, Qingsu AU - Yin, Jun Jie AU - Lin, Ge AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2011/09/10/ PY - 2011 DA - 2011 Sep 10 SP - 302 EP - 309 VL - 205 IS - 3 KW - Carcinogens KW - 0 KW - Indicators and Reagents KW - Linoleic Acids KW - Lipid Peroxides KW - Pyrrolizidine Alkaloids KW - Reactive Oxygen Species KW - Solvents KW - Superoxides KW - 11062-77-4 KW - Singlet Oxygen KW - 17778-80-2 KW - methyl linoleate KW - 24N6726DE5 KW - methyl linoleate hydroperoxide KW - 27323-65-5 KW - Sodium Azide KW - 968JJ8C9DV KW - Deuterium KW - AR09D82C7G KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione KW - GAN16C9B8O KW - Methanol KW - Y4S76JWI15 KW - Index Medicus KW - Linoleic Acids -- radiation effects KW - Ultraviolet Rays KW - Superoxide Dismutase -- metabolism KW - Linoleic Acids -- chemistry KW - Singlet Oxygen -- chemistry KW - Superoxides -- chemistry KW - Superoxides -- metabolism KW - Spin Trapping KW - Solvents -- chemistry KW - Sodium Azide -- chemistry KW - Electron Spin Resonance Spectroscopy KW - Kinetics KW - Glutathione -- chemistry KW - Indicators and Reagents -- chemistry KW - Methanol -- chemistry KW - Glutathione -- analogs & derivatives KW - Carcinogens -- radiation effects KW - Carcinogens -- chemistry KW - Lipid Peroxides -- chemistry KW - Carcinogens -- toxicity KW - Reactive Oxygen Species -- chemistry KW - Pyrrolizidine Alkaloids -- toxicity KW - Pyrrolizidine Alkaloids -- radiation effects KW - Pyrrolizidine Alkaloids -- chemistry KW - Lipid Peroxides -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880998447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Photoirradiation+of+dehydropyrrolizidine+alkaloids--formation+of+reactive+oxygen+species+and+induction+of+lipid+peroxidation.&rft.au=Zhao%2C+Yuewei%3BXia%2C+Qingsu%3BYin%2C+Jun+Jie%3BLin%2C+Ge%3BFu%2C+Peter+P&rft.aulast=Zhao&rft.aufirst=Yuewei&rft.date=2011-09-10&rft.volume=205&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2011.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-10-05 N1 - Date created - 2011-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2011.06.020 ER - TY - JOUR T1 - Performance comparison of three types of high-speed counter-current chromatographs for the separation of components of hydrophilic and hydrophobic color additives AN - 1266752957; 15591076 AB - The performance of three types of high-speed counter-current chromatography (HSCCC) instruments was assessed for their use in separating components in hydrophilic and hydrophobic dye mixtures. The HSCCC instruments compared were: (i) a J-type coil planet centrifuge (CPC) system with a conventional multilayer-coil column, (ii) a J-type CPC system with a spiral-tube assembly-coil column, and (iii) a cross-axis CPC system with a multilayer-coil column. The hydrophilic dye mixture consisted of a sample of FD&C Blue No. 2 that contained mainly two isomeric components, 5,5'- and 5,7'-disulfonated indigo, in the ratio of [not, vert, similar]7:1. The hydrophobic dye mixture consisted of a sample of D&C Red No. 17 (mainly Sudan III) and Sudan II in the ratio of [not, vert, similar]4:1. The two-phase solvent systems used for these separations were 1-butanol/1.3 M HCl and hexane/acetonitrile. Each of the three instruments was used in two experiments for the hydrophilic dye mixture and two for the hydrophobic dye mixture, for a total of 12 experiments. In one set of experiments, the lower phase was used as the mobile phase, and in the second set of experiments, the upper phase was used as the mobile phase. The results suggest that: (a) use of a J-type instrument with either a multilayer-coil column or a spiral-tube assembly column, applying the lower phase as the mobile phase, is preferable for separating the hydrophilic components of FD&C Blue No. 2; and (b) use of a J-type instrument with multilayer-coil column, while applying either the upper phase or the lower phase as the mobile phase, is preferable for separating the hydrophobic dye mixture of D&C Red No. 17 and Sudan II. JF - Journal of Chromatography A AU - Weisz, Adrian AU - Ito, Yoichiro Y1 - 2011/09/09/ PY - 2011 DA - 2011 Sep 09 SP - 6156 EP - 6164 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1218 IS - 36 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts KW - High-speed counter-current chromatography KW - J-type coil planet centrifuge KW - Cross-axis coil planet centrifuge KW - Multilayer-coil column KW - Spiral-tube assembly column KW - HPLC KW - Color additives KW - FD&C Blue No. 2 KW - D&C Red No. 17 KW - Sudan II KW - Chromatography KW - Chromatographic techniques KW - Solvents KW - Sudan KW - Color KW - Colour KW - Performance Evaluation KW - Analytical Methods KW - Centrifuges KW - Additives KW - SW 5010:Network design KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1266752957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Performance+comparison+of+three+types+of+high-speed+counter-current+chromatographs+for+the+separation+of+components+of+hydrophilic+and+hydrophobic+color+additives&rft.au=Weisz%2C+Adrian%3BIto%2C+Yoichiro&rft.aulast=Weisz&rft.aufirst=Adrian&rft.date=2011-09-09&rft.volume=1218&rft.issue=36&rft.spage=6156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.12.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Colour; Centrifuges; Chromatographic techniques; Solvents; Additives; Performance Evaluation; Chromatography; Analytical Methods; Color; Sudan DO - http://dx.doi.org/10.1016/j.chroma.2010.12.034 ER - TY - JOUR T1 - Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter. AN - 880715004; 21708214 AB - Welding results in a unique and complex occupational exposure. Recent epidemiological studies have shown an increased risk of cardiovascular disease following welding fume exposure. In this study, we compared the induction of pulmonary and systemic inflammation following exposure to multiple types of welding fumes. Mice were exposed to 340μg of manual metal arc stainless steel (MMA-SS), gas metal arc-SS (GMA-SS) or GMA-mild steel (GMA-MS) by pharyngeal aspiration. Mice were sacrificed at 4 and 24h post-exposure to evaluate various parameters of pulmonary and systemic inflammation. Alterations in pulmonary gene expression by a custom designed TaqMan array showed minimal differences between the fumes at 4h. Conversely at 24h, gene expression changes were further increased by SS but not GMA-MS exposure. These findings were associated with the surrogate marker of systemic inflammation, liver acute phase gene induction. Interestingly, stress response genes in cardiovascular tissues were only increased following MMA-SS exposure. These effects were related to the initial level of pulmonary cytotoxicity, as measured by lactate dehydrogenase activity, which was greatest following MMA-SS exposure. In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Erdely, Aaron AU - Salmen-Muniz, Rebecca AU - Liston, Angie AU - Hulderman, Tracy AU - Zeidler-Erdely, Patti C AU - Antonini, James M AU - Simeonova, Petia P AD - Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, United States. efi4@cdc.gov Y1 - 2011/09/05/ PY - 2011 DA - 2011 Sep 05 SP - 153 EP - 159 VL - 287 IS - 1-3 KW - Biomarkers KW - 0 KW - Particulate Matter KW - RNA, Messenger KW - Index Medicus KW - Animals KW - Bronchoalveolar Lavage Fluid -- chemistry KW - RNA, Messenger -- analysis KW - Mice, Inbred C57BL KW - Cardiovascular System -- metabolism KW - Mice KW - Cardiovascular System -- drug effects KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Particulate Matter -- toxicity KW - Inflammation -- chemically induced KW - Lung -- drug effects KW - Welding KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/880715004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Relationship+between+pulmonary+and+systemic+markers+of+exposure+to+multiple+types+of+welding+particulate+matter.&rft.au=Erdely%2C+Aaron%3BSalmen-Muniz%2C+Rebecca%3BListon%2C+Angie%3BHulderman%2C+Tracy%3BZeidler-Erdely%2C+Patti+C%3BAntonini%2C+James+M%3BSimeonova%2C+Petia+P&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2011-09-05&rft.volume=287&rft.issue=1-3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2011.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-09-30 N1 - Date created - 2011-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2011.06.008 ER - TY - JOUR T1 - Cerium oxide nanoparticle-induced pulmonary inflammation and alveolar macrophage functional change in rats AN - 926891879; 16401676 AB - The use of cerium compounds as diesel fuel catalyst results in the emission of cerium oxide nanoparticles (CeO sub(2)) in the exhaust. This study characterized the potential effects of CeO sub(2) exposure on lung toxicity. Male Sprague Dawley rats were exposed to CeO sub(2) by a single intratracheal instillation at 0.15, 0.5, 1, 3.5 or 7 mg/kg body weight. At 1 day after exposure, CeO sub(2) significantly reduced NO production, but increased IL-12 production, by alveolar macrophages (AM) in response to ex vivo lipopolysacchride (LPS) challenge, and caused AM apoptosis, through activation of caspases 9 and 3. CeO sub(2) exposure markedly increased suppressor of cytokine signaling-1 at 1-day and elevated arginase-1 at 28-day post exposure in lung cells, while osteopontin was significantly elevated in lung tissue at both time points. CeO sub(2) induced inflammation, cytotoxicity, air/blood barrier damage, and phospholipidosis with enlarged AM. Thus, CeO sub(2) induced lung inflammation and injury in lungs which may lead to fibrosis. JF - Nanotoxicology AU - Ma, J Y AU - Zhao, H AU - Mercer, R R AU - Barger, M AU - Rao, M AU - Meighan, T AU - Schwegler-Berry, D AU - Castranova, V AU - Ma, J K AD - PPRB/HELD, NIOSH, 1095 Willowdale Road, Morgantown, West Virginia 26505-2888, USA, iym1@cdc.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 312 EP - 325 VL - 5 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Alveoli KW - Lung KW - X 24370:Natural Toxins KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Cerium+oxide+nanoparticle-induced+pulmonary+inflammation+and+alveolar+macrophage+functional+change+in+rats&rft.au=Ma%2C+J+Y%3BZhao%2C+H%3BMercer%2C+R+R%3BBarger%2C+M%3BRao%2C+M%3BMeighan%2C+T%3BSchwegler-Berry%2C+D%3BCastranova%2C+V%3BMa%2C+J+K&rft.aulast=Ma&rft.aufirst=J&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.519835 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Lung DO - http://dx.doi.org/10.3109/17435390.2010.519835 ER - TY - JOUR T1 - Uptake of gold nanoparticles in murine macrophage cells without cytotoxicity or production of pro-inflammatory mediators AN - 926891872; 16401674 AB - More information characterizing the biological responses to nanoparticles is needed to allow the U.S. Food and Drug Administration to evaluate the safety and effectiveness of products with nano-scale components. The potential cytotoxicity and inflammatory responses of Au NPs (60 nm, NIST standard reference materials) were investigated in murine macrophages. Cytotoxicity was evaluated by MTT and LDH assays. Cytokines (IL-6, TNF- alpha ), nitric oxide, and ROS were assayed to assess inflammatory responses. Morphological appearance and localization of particles were examined by high resolution illumination microscopy, transmission electron microscopy (TEM), and scanning TEM coupled with EDX spectroscopy. Results showed no cytotoxicity and no elevated production of proinflammatory mediators; however, imaging analyses demonstrated cellular uptake of Au NPs and localization within intracellular vacuoles. These results suggest that 60 nm Au NPs, under the exposure conditions tested, are not cytotoxic, nor elicit pro-inflammatory responses. The localization of Au NPs in intracellular vacuoles suggests endosomal containment and an uptake mechanism involving endocytosis. JF - Nanotoxicology AU - Zhang, Q AU - Hitchins, V M AU - Schrand, A M AU - Hussain, S M AU - Goering, P L AD - Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Ave, Bldg 64, Rm 4064, Silver Spring, MD 20993, USA, peter.goering@fda.hhs.gov Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 284 EP - 295 VL - 5 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Cytotoxicity KW - Inflammation KW - F 06960:Molecular Immunology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/926891872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Uptake+of+gold+nanoparticles+in+murine+macrophage+cells+without+cytotoxicity+or+production+of+pro-inflammatory+mediators&rft.au=Zhang%2C+Q%3BHitchins%2C+V+M%3BSchrand%2C+A+M%3BHussain%2C+S+M%3BGoering%2C+P+L&rft.aulast=Zhang&rft.aufirst=Q&rft.date=2011-09-01&rft.volume=5&rft.issue=3&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2010.512401 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Inflammation DO - http://dx.doi.org/10.3109/17435390.2010.512401 ER - TY - JOUR T1 - Symptoms of Infectious Diseases in Immunocompromised Travelers: A Prospective Study With Matched Controls AN - 911154313; 15994660 AB - Background. Immunocompromised travelers to developing countries are thought to have symptomatic infectious diseases more often and longer than non-immunocompromised travelers. Evidence for this is lacking. This study evaluates whether immunocompromised short-term travelers are at increased risk of diseases. Methods. A prospective study was performed between October 2003 and May 2010 among adult travelers using immunosuppressive agents (ISA) and travelers with inflammatory bowel disease (IBD), with their non-immunocompromised travel companions serving as matched controls with comparable exposure to infection. Data on symptoms of infectious diseases were recorded by using a structured diary. Results. Among 75 ISA, the incidence of travel-related diarrhea was 0.76 per person-month, and the number of symptomatic days 1.32 per month. For their 75 controls, figures were 0.66 and 1.50, respectively (p > 0.05). Among 71 IBD, the incidence was 1.19, and the number of symptomatic days was 2.48. For their 71 controls, figures were 0.73 and 1.31, respectively (p > 0.05). These differences also existed before travel. ISA had significantly more and longer travel-related signs of skin infection and IBD suffered more and longer from vomiting. As for other symptoms, no significant travel-related differences were found. Only 21% of immunocompromised travelers suffering from diarrhea used their stand-by antibiotics. Conclusions. ISA and IBD did not have symptomatic infectious diseases more often or longer than non-immunocompromised travelers, except for signs of travel-related skin infection among ISA. Routine prescription of stand-by antibiotics for these immunocompromised travelers to areas with good health facilities is probably not more useful than for healthy travelers. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Geskus, Ronald B AU - Kint, Joan A AU - Roukens, Anna HE AU - Sonder, Gerard J AU - van den Hoek, Anneke AD - Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands Y1 - 2011/09// PY - 2011 DA - Sep 2011 SP - 318 EP - 326 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 18 IS - 5 SN - 1195-1982, 1195-1982 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Risk Abstracts KW - Travel KW - Symptoms KW - Skin KW - Fish diseases KW - Infectious diseases KW - infection KW - Antibiotics KW - Developing countries KW - Q1 08625:Non-edible products KW - Q5 08504:Effects on organisms KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911154313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Symptoms+of+Infectious+Diseases+in+Immunocompromised+Travelers%3A+A+Prospective+Study+With+Matched+Controls&rft.au=Baaten%2C+Gijs+G%3BGeskus%2C+Ronald+B%3BKint%2C+Joan+A%3BRoukens%2C+Anna+HE%3BSonder%2C+Gerard+J%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2011-09-01&rft.volume=18&rft.issue=5&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2011.00543.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Document feature - figure 0 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Symptoms; Infectious diseases; Fish diseases; Antibiotics; Developing countries; Travel; Skin; infection DO - http://dx.doi.org/10.1111/j.1708-8305.2011.00543.x ER - TY - JOUR T1 - Personality and Obesity Across the Adult Life Span AN - 908021642; 201122471 AB - Personality traits contribute to health outcomes, in part through their association with major controllable risk factors, such as obesity. Body weight, in turn, reflects our behaviors and lifestyle and contributes to the way we perceive ourselves and others. In this study, the authors use data from a large (N = 1,988) longitudinal study that spanned more than 50 years to examine how personality traits are associated with multiple measures of adiposity and with fluctuations in body mass index (BMI). Using 14,531 anthropometric assessments, the authors modeled the trajectory of BMI across adulthood and tested whether personality predicted its rate of change. Measured concurrently, participants higher on Neuroticism or Extraversion or lower on Conscientiousness had higher BMI; these associations replicated across body fat, waist, and hip circumference. The strongest association was found for the impulsivity facet: Participants who scored in the top 10% of impulsivity weighed, on average, 11Kg more than those in the bottom 10%. Longitudinally, high Neuroticism and low Conscientiousness, and the facets of these traits related to difficulty with impulse control, were associated with weight fluctuations, measured as the variability in weight over time. Finally, low Agreeableness and impulsivity-related traits predicted a greater increase in BMI across the adult life span. BMI was mostly unrelated to change in personality traits. Personality traits are defined by cognitive, emotional, and behavioral patterns that likely contribute to