TY - GEN T1 - 15 Years of Fish Drug Approvals: A Success Story AN - 846767174 AB - Due to joint efforts by the aquaculture industry, government, academia, and drug companies, the fish drug arsenal grew over the last 15 years. Since 1995, FDA approved seven drugs and 14 different label claims for fish. A session at the 2010 World Aquaculture Society conference, held in San Diego, California, earlier this year, highlighted these drug approval successes. JF - FDA Veterinarian AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Fish KW - FDA approval KW - Aquaculture KW - Drugs KW - Fishing industry KW - San Diego California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=15+Years+of+Fish+Drug+Approvals%3A+A+Success+Story&rft.au=McLean%2C+Melanie%2C+DVM&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - JOUR T1 - Moving Forward in Human Cancer Risk Assessment AN - 1677921891; 15090549 AB - The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks. We provide a response to a growing appeal for a paradigm change in human cancer risk assessment. To facilitate development of a road map for this needed paradigm change in carcinogenicity testing, a workshop titled "Genomics in Cancer Risk Assessment" brought together toxicologists from academia and industry and government regulators and risk assessors from the United States and the European Union. Participants discussed the state-of-the-art in developing alternative testing strategies for carcinogenicity, with emphasis on potential contributions from omics technologies. The goal of human risk assessment is to decide whether a given exposure to an agent is acceptable to human health and to provide risk management measures based on evaluating and predicting the effects of exposures on human health. Although exciting progress is being made using genomics approaches, a new paradigm that uses these methods and human material when possible would provide mechanistic insights that may inform new predictive approaches (e.g., in vitro assays) and facilitate the development of genomics-derived biomarkers. Regulators appear to be willing to accept such approaches where use is clearly defined, evidence is strong, and approaches are qualified for regulatory use. JF - Environmental Health Perspectives AU - Paules, Richard S AU - Aubrecht, Jiri AU - Corvi, Raffaella AU - Garthoff, Bernward AU - Kleinjans, Jos C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 739 EP - 743 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 6 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - cancer KW - human KW - omics technologies KW - risk assessment KW - systems biology KW - Risk assessment KW - Risk KW - In vitro testing KW - Human KW - Exposure KW - Health KW - Cancer KW - Bioassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677921891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Moving+Forward+in+Human+Cancer+Risk+Assessment&rft.au=Paules%2C+Richard+S%3BAubrecht%2C+Jiri%3BCorvi%2C+Raffaella%3BGarthoff%2C+Bernward%3BKleinjans%2C+Jos+C&rft.aulast=Paules&rft.aufirst=Richard&rft.date=2010-12-13&rft.volume=119&rft.issue=6&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002735 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002735 ER - TY - JOUR T1 - Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels AN - 1677904471; 15090571 AB - Benzene, an established cause of acute myeloid leukemia (AML), may also cause one or more lymphoid malignancies in humans. Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers. The goals of this study were to identify potential biomarkers of benzene exposure and/or early effects and to elucidate mechanisms relevant to risk of hematotoxicity, leukemia, and lymphoid malignancy in occupationally exposed individuals, many of whom were exposed to benzene levels & 1 ppm, the current U.S. occupational standard. We analyzed global gene expression in the peripheral blood mononuclear cells of 125 workers exposed to benzene levels ranging from & 1 ppm to > 10 ppm. Study design and analysis with a mixed-effects model minimized potential confounding and experimental variability. We observed highly significant widespread perturbation of gene expression at all exposure levels. The AML pathway was among the pathways most significantly associated with benzene exposure. Immune response pathways were associated with most exposure levels, potentially providing biological plausibility for an association between lymphoma and benzene exposure. We identified a 16-gene expression signature associated with all levels of benzene exposure. Our findings suggest that chronic benzene exposure, even at levels below the current U.S. occupational standard, perturbs many genes, biological processes, and pathways. These findings expand our understanding of the mechanisms by which benzene may induce hematotoxicity, leukemia, and lymphoma and reveal relevant potential biomarkers associated with a range of exposures. JF - Environmental Health Perspectives AU - McHale, Cliona M AU - Zhang, Luoping AU - Lan, Qing AU - Vermeulen, Roel AU - Li, Guilan AU - Hubbard, Alan E AU - Porter, Kristin E AU - Thomas, Reuben AU - Portier, Christopher J AU - Shen, Min AU - Rappaport, Stephen M AU - Yin, Songnian AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 628 EP - 640 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - benzene KW - biomarker KW - human KW - microarray KW - transcriptomics KW - Gene expression KW - Pathways KW - Occupational KW - Exposure KW - Biological KW - Standards KW - Leukemias KW - Benzene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677904471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Gene+Expression+Profiling+of+a+Population+Exposed+to+a+Range+of+Benzene+Levels&rft.au=McHale%2C+Cliona+M%3BZhang%2C+Luoping%3BLan%2C+Qing%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BHubbard%2C+Alan+E%3BPorter%2C+Kristin+E%3BThomas%2C+Reuben%3BPortier%2C+Christopher+J%3BShen%2C+Min%3BRappaport%2C+Stephen+M%3BYin%2C+Songnian%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=McHale&rft.aufirst=Cliona&rft.date=2010-12-13&rft.volume=119&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002546 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002546 ER - TY - JOUR T1 - Survey and risk assessment of trace elements in foods from Taiwan containing red mould rice (Monascus) by ICP-MS AN - 907180009; 15716368 AB - The concentrations of seven trace elements (As, Cd, Cr, Pb, Se, Cu and Zn) in 93 red mould rice (Monascus) food samples in Taipei, Taiwan, were determined by inductively coupled plasma-mass spectrometry (ICP-MS) after wet digestion. The results, calculated in mg kg-1 (wet weight) for each sample, revealed the general scenario of food safety in Taiwan: As (0.005-12.04), Cd (<0.0005-2.22), Cr (0.014-6.95), Cu (0.012-8.70), Pb (0.001-0.64), Se (<0.001-1.29) and Zn (0.020-67.02). Three food samples were identified with As concentrations higher than regulatory limits: a dietary supplement sample and a seaweed sample with As concentrations that exceeded the limit of Taiwan's health food standard of 2 mg kg-1, and a canned eel sample with an As concentration that exceeded the limit of Canada's fish standard of 3.5 mg kg-1. This study suggests that the estimated intakes of these seven trace elements from the consumption of foods containing Monascus pose little risk, as the trace element contents in the majority of samples were lower than the permissible/tolerable intakes per week according to the guidelines recommended by the Food and Agricultural Organization/World Health Organization (FAO/WHO). Moreover, their concentrations in foods containing Monascus differ widely for different food varieties, suggesting that external contaminants and raw materials are the main sources of trace elements. This study shows that ICP-MS is a simple method proposed for the determination of As, Cd, Cr, Pb, Se, Cu, and Zn in foods containing Monascus. JF - Food Additives & Contaminants: Part B - Surveillance Communications AU - Tsai, C-F AU - Shih, DY-C AU - Shyu, Y-T AD - Department of Horticulture, National Taiwan University, Taipei, 106, Taiwan, R.O.C,Department of Health, Executive Yuan, Food and Drug Administration, Taipei 115, Taiwan, R.O.C Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 228 EP - 235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 3 IS - 4 SN - 1939-3210, 1939-3210 KW - Risk Abstracts KW - Taiwan KW - dietary supplements KW - Oryza sativa KW - Taiwan, Taipei KW - Lead KW - Trace elements KW - Spectrometry KW - Zinc KW - Monascus KW - raw materials KW - Cadmium KW - Fish KW - Seaweeds KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907180009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+and+risk+assessment+of+trace+elements+in+foods+from+Taiwan+containing+red+mould+rice+%28Monascus%29+by+ICP-MS&rft.au=Tsai%2C+C-F%3BShih%2C+DY-C%3BShyu%2C+Y-T&rft.aulast=Tsai&rft.aufirst=C-F&rft.date=2010-12-01&rft.volume=3&rft.issue=4&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.issn=19393210&rft_id=info:doi/10.1080%2F19393210.2010.513070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - dietary supplements; Zinc; raw materials; Fish; Cadmium; Seaweeds; Lead; Spectrometry; Trace elements; Monascus; Oryza sativa; Taiwan; Taiwan, Taipei DO - http://dx.doi.org/10.1080/19393210.2010.513070 ER - TY - JOUR T1 - Bioaccumulation of cyanuric acid in edible tissues of shrimp following experimental feeding AN - 899137285; 15716319 AB - Due to concerns that cyanuric acid (CYA)-contaminated feed had been used in aquaculture and could enter the human food chain, a method to quantify CYA residues in the edible tissues of fish and shrimp was previously developed and validated. This paper provides further data on the deliberate feeding of CYA to shrimp to determine the extent of residue accumulation in edible tissue. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed for the analysis of CYA in shrimp tissue. Edible tissue of shrimp fed 1666 or 3333 mg kg-1 CYA in their diet (approximately 55 and 124 mg kg-1 body weight) contained 0.767 and 0.406 mg kg-1 CYA, respectively. The residue levels are below the World Health Organization (WHO) tolerable daily intake level for CYA and are generally considered unlikely to pose a human health risk. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Karbiwnyk, Christine M AU - Williams, Rodney R AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Madson, Mark R AU - Miller, Keith E AU - Reimschuessel, Renate AD - Animal Drugs Research Center, US Food and Drug Administration, Denver, CO 80225-0087, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1658 EP - 1664 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 27 IS - 12 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Aquaculture KW - Diets KW - Fish KW - Food additives KW - Food chains KW - Residues KW - Tissues KW - body weight KW - feeding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899137285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Bioaccumulation+of+cyanuric+acid+in+edible+tissues+of+shrimp+following+experimental+feeding&rft.au=Karbiwnyk%2C+Christine+M%3BWilliams%2C+Rodney+R%3BAndersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E%3BReimschuessel%2C+Renate&rft.aulast=Karbiwnyk&rft.aufirst=Christine&rft.date=2010-12-01&rft.volume=27&rft.issue=12&rft.spage=1658&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2010.517221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Diets; Tissues; Food additives; Food chains; Residues; feeding; Fish; body weight; Aquaculture DO - http://dx.doi.org/10.1080/19440049.2010.517221 ER - TY - JOUR T1 - Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials AN - 888099785; 15039043 AB - A two-stage adaptive design trial is a single trial that combines the learning data from stage 1 (or phase II) and the confirming data in stage 2 (or phase III) for formal statistical testing. We call it a 'Learn and Confirm' trial. The studywise type I error rate remains to be at issue in a 'Learn and Confirm' trial. For studying multiple doses or multiple enpdoints, a 'Learn and Confirm' adaptive design can be more attractive than a fixed design approach. This is because intuitively the learning data in stage 1 should not be subjected to type I error scrutiny if there is no formal interim analysis performed and only an adaptive selection of design parameters is made at stage 1. In this work, we conclude from extensive simulation studies that the intuition is most often misleading. That is, regardless of whether or not there is a formal interim analysis for making an adaptive selection, the type I error rates are always at risk of inflation. Inappropriate use of any 'Learn and Confirm' strategy should not be overlooked. JF - Biometrical Journal AU - Wang, Sue-Jane AU - Hung, H M James AU - O'Neill, Robert T AD - Office of Biostatistics, OTS/CDER, US FDA, 10903 New Hampshire Avenue, HFD-700, Silver Spring, MD 20993-0002, USA, suejane.wang@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 798 EP - 810 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 6 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Statistics KW - Biometrics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Injury+Surveillance+for+Youth+on+Farms+in+the+U.S.%2C+2006&rft.au=Hendricks%2C+K+J%3BGoldcamp%2C+E+M&rft.aulast=Hendricks&rft.aufirst=K&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.200900207/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Learning; Statistics; Data processing; Biometrics DO - http://dx.doi.org/10.1002/bimj.200900207 ER - TY - JOUR T1 - Challenges to multiple testing in clinical trials AN - 888099107; 15039039 AB - Multiple testing problems are complex in evaluating statistical evidence in pivotal clinical trials for regulatory applications. However, a common practice is to employ a general and rather simple multiple comparison procedure to handle the problems. Applying multiple comparison adjustments is to ensure proper control of type I error rates. However, in many practices, the emphasis of the type I error rate control often leads to a choice of a statistically valid multiple test procedure but the common sense is overlooked. The challenges begin with confusions in defining a relevant family of hypotheses for which the type I error rates need to be properly controlled. Multiple testing problems are in a wide variety, ranging from testing multiple doses and endpoints jointly, composite endpoint, non-inferiority and superiority, to studying time of onset of a treatment effect, and searching for minimum effective dose or a patient subgroup in which the treatment effect lies. To select a valid and sensible multiple test procedure, the first step should be to tailor the selection to the study questions and to the ultimate clinical decision tree. Then evaluation of statistical power performance should come in to play in the next step to fine tune the selected procedure. JF - Biometrical Journal AU - Hung, H M James AU - Wang, Sue-Jane AD - Division of Biometrics I, OB/OTS/CDER, US FDA, 10903 New Hampshire Ave, HFD-710, Silver Spring, MD 20993-0002, USA, hsienming.hung@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 747 EP - 756 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 6 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Play KW - Biometrics KW - Clinical trials KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Challenges+to+multiple+testing+in+clinical+trials&rft.au=Hung%2C+H+M+James%3BWang%2C+Sue-Jane&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2010-12-01&rft.volume=52&rft.issue=6&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=15214036&rft_id=info:doi/10.1002%2Fbimj.200900206 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.200900206/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Play; Statistics; Biometrics; Clinical trials DO - http://dx.doi.org/10.1002/bimj.200900206 ER - TY - JOUR T1 - Antimicrobial Resistance of Campylobacter Isolates from Retail Meat in the United States between 2002 and 2007 AN - 888093057; 14191121 AB - The emergence of antimicrobial resistance in Campylobacter spp. has been a growing public health concern globally. The objectives of this study were to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Campylobacter spp. recovered by the National Antimicrobial Resistance Monitoring System (NARMS) retail meat program. Retail meat samples (n = 24,566) from 10 U.S. states collected between 2002 and 2007, consisting of 6,138 chicken breast, 6,109 ground turkey, 6,171 ground beef, and 6,148 pork chop samples, were analyzed. A total of 2,258 Campylobacter jejuni, 925 Campylobacter coli, and 7 Campylobacter lari isolates were identified. Chicken breast samples showed the highest contamination rate (49.9%), followed by ground turkey (1.6%), whereas both pork chops and ground beef had <0.5% contamination. The most common resistance was to doxycycline/tetracycline (46.6%), followed by nalidixic acid (18.5%), ciprofloxacin (17.4%), azithromycin and erythromycin (2.8%), telithromycin (2.4%), clindamycin (2.2%), and gentamicin (<0.1%). In a subset of isolates tested, no resistance to meropenem and florfenicol was seen. C. coli isolates showed higher resistance rates to antimicrobials, with the exception of doxycycline/tetracycline, than those seen for C. jejuni. Pulsed-field gel electrophoresis (PFGE) fingerprinting resulted in 1,226 PFGE profiles among the 2,318 isolates, with many clones being widely dispersed throughout the 6-year sampling period. JF - Applied and Environmental Microbiology AU - Zhao, S AU - Young AU - Tong, E AU - Abbott, J W AU - Womack, N AU - Friedman, S L AU - McDermott, P F AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, shaohua.zhao@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 7949 EP - 7956 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 24 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Meat KW - Campylobacter coli KW - A:01330 KW - J:02400 KW - X:24320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888093057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Antimicrobial+Resistance+of+Campylobacter+Isolates+from+Retail+Meat+in+the+United+States+between+2002+and+2007&rft.au=Zhao%2C+S%3BYoung%3BTong%2C+E%3BAbbott%2C+J+W%3BWomack%2C+N%3BFriedman%2C+S+L%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2010-12-01&rft.volume=76&rft.issue=24&rft.spage=7949&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01297-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Meat; Campylobacter coli DO - http://dx.doi.org/10.1128/AEM.01297-10 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF [Beta]-MYRCENE (CAS NO. 123-35-3) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878683497; 21415873 AB - β-Myrcene is the major component of hop and bay oils and lemongrass tea, and is also produced commercially rom β-pinene. It is used widely in cosmetics, soaps and detergents and is a flavoring agent in foods and beverages. We studied the effects of β-myrcene on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing β-myrcene in corn oil directly into the stomach through a tube to groups of 50 male and female rats and mice for two years. Exposed animals received either 0.25, 0.5, or 1.0 gram of β-myrcene per kilogram of body weight. Control animals received corn oil with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. All the male rats receiving 1.0 g/kg β-myrcene and most of the male and female mice receiving 1.0 g/kg β-myrcene died before the end of the study. In the other two groups of male rats receiving β-myrcene the incidences of kidney tumors was markedly increased. Female rats also experienced some kidney tumors, to a lesser extent. Similarly male mice had markedly increased incidences of adenomas and carcinomas of the liver, as did female mice to a lesser extent. We conclude that β-myrcene caused kidney cancers in male rats and liver cancer in male mice, and the occurrence of kidney tumors in female rats and liver tumors in female rats may have been related to β-myrcene administration. In addition β-myrcene was associated with other lesions of the kidney in rats, the liver in mice, and the nose in male rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1 EP - 163 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Monoterpenes KW - beta-myrcene KW - Studies KW - Toxicology KW - Carcinogens KW - Chemicals KW - Rodents KW - Animals KW - Kidney Neoplasms -- pathology KW - Kidney -- pathology KW - Humans KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Mice KW - Neoplasms, Experimental -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Liver Neoplasms -- pathology KW - Nose -- pathology KW - Toxicity Tests, Chronic KW - Carcinogenicity Tests KW - Carcinoma, Hepatocellular -- pathology KW - Nose -- drug effects KW - Adenoma -- pathology KW - Male KW - Female KW - Hepatoblastoma -- pathology KW - Monoterpenes -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Kidney Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Hepatoblastoma -- chemically induced KW - Carcinoma, Hepatocellular -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+%5BBeta%5D-MYRCENE+%28CAS+NO.+123-35-3%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Document feature - Tables; Equations; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683486 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683485 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Occupational Distribution of Persons With Confirmed 2009 H1N1 Influenza AN - 874182450; 14292380 AB - Objective: To assess the distribution of illness by industry sector and occupation reflected in early 2009 H1N1 influenza surveillance. Methods: We analyzed data reported for April to July 2009, for 1361 laboratory-confirmed 2009 H1N1 influenza-infected persons 16 years or older, with work status information from four states. A North American Industry Classification System 2007 code was assigned to each employed person. For a subset, an occupation code was assigned. Results: Of 898 employed individuals, 611 (68.0%) worked in the non-health care sector. The largest proportions worked in public administration, educational services, and accommodation and food services. In Wisconsin health care personnel, 53.6% were paraprofessionals, 33.6% professionals, and 12.7% other workers; 26.9% worked in ambulatory settings, 46.2% in hospitals, and 26.9% in nursing or residential care facilities. Conclusions: Our findings suggest that industry sectors and occupations should be explored systematically in future influenza surveillance. JF - Journal of Occupational and Environmental Medicine AU - Suarthana, E AU - Laney, A S AU - Kreiss, K AU - Anderson, HA AU - Hunt, D C AU - Neises, D AU - Goodin, K AU - Thomas, A AU - Vandermeer, M AU - Storey, E AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Room 2806, Morgantown, WV 26505, USA, ESuarthana@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1212 EP - 1216 VL - 52 IS - 12 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Classification KW - Classification systems KW - Data processing KW - Food KW - Health care KW - Hospitals KW - Influenza KW - Medical personnel KW - Nursing KW - Personnel KW - influenza KW - USA, Wisconsin KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874182450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Distribution+of+Persons+With+Confirmed+2009+H1N1+Influenza&rft.au=Suarthana%2C+E%3BLaney%2C+A+S%3BKreiss%2C+K%3BAnderson%2C+HA%3BHunt%2C+D+C%3BNeises%2C+D%3BGoodin%2C+K%3BThomas%2C+A%3BVandermeer%2C+M%3BStorey%2C+E&rft.aulast=Suarthana&rft.aufirst=E&rft.date=2010-12-01&rft.volume=52&rft.issue=12&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181fd32e4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Classification systems; Influenza; Data processing; Personnel; Nursing; Food; Medical personnel; Hospitals; Health care; Classification; influenza; USA, Wisconsin DO - http://dx.doi.org/10.1097/JOM.0b013e3181fd32e4 ER - TY - JOUR T1 - Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein AN - 874180273; 14163867 AB - The development of malignant prostate cancer involves multiple genetic alterations. For example, alterations in both survivin and p53 are reported to have crucial roles in prostate cancer progression. However, little is known regarding the interrelationships between p53 and survivin in prostate cancer. Our data demonstrate that the expression of survivin is inversely correlated with that of wtp53 protein (r sub(s)=0.548) in prostate cancer and in normal prostate tissues. We have developed a therapeutic strategy, in which two antitumor factors, small interfering RNA-survivin and p53 protein, are co-expressed from the same plasmid, and have examined their effects on the growth of PC3, an androgen-independent prostate cancer cell line. When p53 was expressed along with a survivin-specific short hairpin RNA (shRNA), tumor cell proliferation was significantly suppressed and apoptosis occurred. In addition, this combination also abrogated the expression of downstream target molecules such as cyclin-dependent kinase 4 and c-Myc, while enhancing the expression of GRIM19. These changes in gene expression occurred distinctly in the presence of survivin-shRNA/wtp53 compared with control or single treatment groups. Intratumoral injection of the co-expressed construct inhibited the growth and survival of tumor xenografts in a nude mouse model. These studies revealed evidence of an interaction between p53 and survivin proteins plus a complex signaling network operating downstream of the wtp53-survivin pathway that actively controls tumor cell proliferation, survival and apoptosis. JF - Cancer Gene Therapy AU - Shao, Y AU - Liu, Y AU - Shao, C AU - Hu, J AU - Li, X AU - Li, F AU - Zhang, L AU - Zhao, D AU - Sun, L AU - Zhao, X AU - Kopecko, D J AU - Kalvakolanu, D V AU - Li, Y AU - Xu, D Q AD - Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 844 EP - 854 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 12 SN - 0929-1903, 0929-1903 KW - Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Cell survival KW - Data processing KW - Apoptosis KW - survivin KW - Gene therapy KW - Animal models KW - Tumors KW - Plasmids KW - Cyclin-dependent kinase 4 KW - Tumor cells KW - p53 protein KW - Tumor cell lines KW - Prostate cancer KW - siRNA KW - Xenografts KW - c-Myc protein KW - Signal transduction KW - W 30905:Medical Applications KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874180273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Enhanced+tumor+suppression+in+vitro+and+in+vivo+by+co-expression+of+survivin-specific+siRNA+and+wild-type+p53+protein&rft.au=Shao%2C+Y%3BLiu%2C+Y%3BShao%2C+C%3BHu%2C+J%3BLi%2C+X%3BLi%2C+F%3BZhang%2C+L%3BZhao%2C+D%3BSun%2C+L%3BZhao%2C+X%3BKopecko%2C+D+J%3BKalvakolanu%2C+D+V%3BLi%2C+Y%3BXu%2C+D+Q&rft.aulast=Shao&rft.aufirst=Y&rft.date=2010-12-01&rft.volume=17&rft.issue=12&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fcgt.2010.41 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Data processing; Gene therapy; survivin; Animal models; Tumors; Cyclin-dependent kinase 4; Plasmids; Tumor cells; p53 protein; Tumor cell lines; Prostate cancer; siRNA; Xenografts; c-Myc protein; Signal transduction DO - http://dx.doi.org/10.1038/cgt.2010.41 ER - TY - GEN T1 - Data Tables for FACES 2006: Head Start Children Go to Kindergarten Report. ACF-OPRE Report AN - 864941166; ED517212 AB - The Head Start Family and Child Experiences Survey (FACES), sponsored by the U.S. Department of Health and Human Services, Administration for Children and Families (ACF), was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children and their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also includes interviews with the child's parents, teachers, and program managers, as well as direct observations of classroom quality. This set of tables is designed to accompany a research brief that describes the group of children who first entered Head Start in fall 2006 either as a 3- or 4-year-old, completed one or two years in the program, and attended kindergarten the year after graduating from Head Start. Head Start Children Go to Kindergarten profiles the demographic characteristics of this group and describes their home and family life. It includes a description of the schools and kindergarten classrooms Head Start graduates attend. The report documents children's gains in a broad set of skills from program entry to Head Start graduation and to the end of the kindergarten year, and investigates the associations between children's skills when entering and leaving Head Start, their skills at the end of Head Start, and their progress through the spring of their kindergarten year (West et al. 2010b). Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They include information on parents' involvement with their children's elementary schools, the level of satisfaction with their children's schools, and parents' beliefs about how well Head Start prepared their children for kindergarten. In the second set of tables, the authors provide information about the schools Head Start children attend for kindergarten, their kindergarten classrooms, and their teachers. The authors include information on the background of the children in their classrooms as well as educational experiences in the classroom. The third set of tables chronicles children's developmental progress from the time they completed Head Start through the end of kindergarten. In the final two sections, the authors explore (1) the associations between children's school readiness skills as they complete Head Start and their developmental outcomes at the end of kindergarten and (2) the associations of child/family and Head Start characteristics with children's development at the end of Head Start and their developmental progress from Head Start entry to the end of kindergarten. They also explore the relationship of children's relative skills at program entry (that is, low, average, or high ability) to their development progress during this time period. (Contains 109 tables and 18 notes.) [For related report, "Head Start Children Go to Kindergarten. ACF-OPRE Report", see ED517211.] AU - Malone, Lizabeth AU - Hulsey, Lara AU - Aikens, Nikki AU - West, Jerry AU - Tarullo, Louisa Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 198 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Program Effectiveness KW - Socioeconomic Status KW - Teacher Attitudes KW - Correlation KW - Classroom Techniques KW - Credentials KW - Outcomes of Education KW - Preschool Education KW - Educational Experience KW - Disadvantaged Youth KW - School Readiness KW - Measures (Individuals) KW - Family Environment KW - Young Children KW - Longitudinal Studies KW - Risk KW - Profiles KW - Reading Readiness KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941166?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - A Second Year in Head Start: Characteristics and Outcomes of Children Who Entered the Program at Age Three. ACF-OPRE Report AN - 864941055; ED517208 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. This brief profiles the second year in the program for 3-year-old Head Start children and families who were newly enrolled in fall 2006 (see Tarullo et al. 2008) and are still attending in spring 2008. FACES selects two groups of first-time enrollees--those entering at age 4 and those entering at age 3--who are expected to attend Head Start for one or two years, respectively, prior to kindergarten entry. The 3-year-old group is of particular interest for several reasons: (1) as the Head Start Program Information Report (PIR) shows, 3-year-olds occupy a growing share of the total population served by Head Start, increasing from 24 percent in 1980 to 40 percent in 2007 (ACF 2010); (2) they may differ in important characteristics from children who enter at age 4 in terms of developmental level and exposure to prior child care experiences; and (3) they have the potential to continue in Head Start for two program years or to leave for another prekindergarten experience. In the first section of the report, the authors provide background on the study methodology and sample. In the next section, they offer information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They also include information on parent involvement in Head Start and their level of satisfaction with their own and their children's Head Start experiences. Where appropriate, these characteristics are contrasted with those of children who entered as 3-year-olds in fall 2006 but did not complete a second year of Head Start. They chronicle children's developmental progress over two years of Head Start in the final section, considering whether these outcomes vary by gender, race/ethnicity, or risk status. It is important to note that changes in children's skills and development during their program experience reflect a range of influences in their lives, including child-level characteristics, such as maturation and health status, as well as community, program, classroom, peer, and family influences. (Contains 14 figures, 1 table and 33 notes.) [For related report, "Data Tables for FACES 2006: A Second Year in Head Start Report. ACF-OPRE Report," see ED517210.] AU - Tarullo, Louisa AU - Aikens, Nikki AU - Moiduddin, Emily AU - West, Jerry Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 32 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Demography KW - Educational Experience KW - Kindergarten KW - Health Conditions KW - Child Development KW - Program Evaluation KW - Preschool Evaluation KW - Gender Differences KW - Educational Indicators KW - Racial Differences KW - Educational Environment KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Educational Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941055?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Head Start Children Go to Kindergarten. ACF-OPRE Report AN - 864941037; ED517211 AB - The Head Start Family and Child Experiences Survey (FACES), sponsored by the U.S. Department of Health and Human Services, Administration for Children and Families (ACF), was first launched in 1997 as a periodic longitudinal study of program performance. This report is the fourth in a series that uses data from the FACES 2006 cohort to describe the population of 3- and 4-year-olds who entered Head Start for the first time in fall 2006, their families, and their classrooms. Guided by the FACES conceptual framework (Figure 1), earlier reports documented the diversity in the Head Start population in terms of demographic and socioeconomic characteristics, the skills that children have when they first enter the program, and the gains in these skills over one or two years of program participation. The current report describes the group of children who first entered Head Start in fall 2006 either as a 3- or 4-year-old, completed one or two years in the program, and attended kindergarten the year after graduating from Head Start. As in the earlier reports, the authors profile the demographic characteristics of this group and describe their home and family life, drawing comparisons where appropriate to the characteristics of the population of children and families when they first entered Head Start or after completing one year in the program. New to this report is a description of the schools and kindergarten classrooms Head Start graduates attend. The authors describe broad characteristics of their schools such as size, student body composition, and school type. They describe children's kindergarten classrooms and teachers, including information on characteristics such as the length of the school day (full- versus half-day kindergarten), class size, child-to-staff ratio, and teachers' experience and degrees. They once again document children's gains in a broad set of skills from program entry to Head Start graduation and to the end of the kindergarten year, and investigate the associations between children's skills when entering and leaving Head Start, their skills at the end of Head Start, and their progress through the spring of their kindergarten year. The findings in the report are intended to answer five research questions: (1) What are the child/family demographics and home environment characteristics of children who complete Head Start and enroll in kindergarten? How involved are their parents in their schools and education?; (2) What are the characteristics of the schools and kindergarten programs children attend after completing Head Start? What are the characteristics of their kindergarten classrooms and teachers?; (3) What developmental gains do children make during Head Start and beyond? How do their skills compare to those of their peers; (4) Are children's school readiness skills at the end of Head Start related to developmental outcomes at the end of kindergarten? Are there cross-domain relationships between children's language, literacy, math, and social-emotional skills?; and (5) What child/family and Head Start characteristics relate to children's development at the end of Head Start and the gains they make from the time they enter Head Start through the spring of kindergarten? Does their growth in school readiness skills vary by their skills when first entering Head Start? The remainder of the report is organized into six sections. First, the authors provide background on the study methodology and sample. Second, they offer information on children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They include information on parents' involvement with their children's elementary schools, the level of satisfaction with their children's schools, and parents' beliefs about how well Head Start prepared their children for kindergarten. Third, they describe the schools Head Start children attend for kindergarten, their kindergarten classrooms, and their teachers. They include information on the background of the children in their classrooms as well as educational experiences in the classroom. Fourth, they chronicle children's developmental progress from the time they completed Head Start through the end of kindergarten, considering whether these outcomes vary by gender, race/ethnicity, or risk status. Fifth, they explore the associations between children's school readiness skills as they complete Head Start and their developmental outcomes at the end of kindergarten. Sixth, they investigate associations of child/family and Head Start characteristics with children's development at the end of Head Start and their developmental progress from Head Start entry to the end of kindergarten. They also explore the relationship of children's relative skills at program entry (that is, low, average, or high ability) to their development progress during this time period. (Contains 2 tables, 26 figures and 70 endnotes.) [For related report, "The Data Tables for FACES 2006: Head Start Children Go to Kindergarten. ACF-OPRE Report", see ED517212.] AU - West, Jerry AU - Malone, Lizabeth AU - Hulsey, Lara AU - Aikens, Nikki AU - Tarullo, Louisa Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 62 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - Peabody Picture Vocabulary Test (Revised) KW - Woodcock Johnson Tests of Achievement KW - Early Childhood Longitudinal Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Student Characteristics KW - Recess Breaks KW - Body Composition KW - Child Care KW - Correlation KW - Whites KW - Minority Groups KW - Hispanic Americans KW - Teaching Experience KW - Parent School Relationship KW - Developmental Stages KW - Child Development KW - Disadvantaged Youth KW - Low Income Groups KW - Family Environment KW - Gender Differences KW - Language Skills KW - Mental Health KW - Racial Differences KW - Teacher Student Ratio KW - Parent Participation KW - Parent Attitudes KW - Program Effectiveness KW - Parent Influence KW - Socioeconomic Status KW - School Schedules KW - Child Health KW - Social Support Groups KW - Student Diversity KW - Discipline KW - Nutrition KW - Mathematics Skills KW - Skill Development KW - Teacher Certification KW - Spanish Speaking KW - Social Development KW - Language of Instruction KW - School Readiness KW - Class Size KW - Institutional Characteristics KW - Cognitive Development KW - Young Children KW - Leisure Time KW - Reading Skills KW - Longitudinal Studies KW - English (Second Language) KW - Emotional Development KW - Interpersonal Competence KW - Early Intervention KW - School Size KW - Physical Activity Level UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941037?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Data Tables for FACES 2006: A Second Year in Head Start Report. ACF-OPRE Report AN - 864939754; ED517210 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers, and program managers, as well as direct observations of classroom quality. FACES is a tool for measuring Head Start program performance at the national level. This recurring data collection provides the means to assess program performance both currently and over time. This set of tables is designed to accompany a research brief which profiles the second year in the program for 3-year-old Head Start children and families who were newly enrolled in fall 2006 (ACF 2010b) and are still attending in spring 2008. FACES selects two groups of first-time enrollees--those entering at age 4 and those entering at age 3--who are expected to attend Head Start for one or two years, respectively, prior to kindergarten entry. The 3-year-old group is of particular interest for several reasons: (1) as the Head Start Program Information Report (PIR) shows, 3-year-olds occupy a growing share of the total population served by Head Start, increasing from 24 percent in 1980 to 40 percent in 2007 (ACF 2010a); (2) they may differ in important characteristics from children who enter at age 4 in terms of developmental level and exposure to prior care experiences; and (3) they have the potential to continue in Head Start for two program years or to leave for another prekindergarten experience. Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. The authors also include information on parent involvement in Head Start and their level of satisfaction with their own and their children's Head Start experiences. In the next set of tables, the authors provide information on children's developmental progress over two years of Head Start, including whether these outcomes vary by gender, race/ethnicity, or risk status. It is important to note that changes in children's skills and development during their program experience reflect a range of influences in their lives, including child-level characteristics, such as maturation and health status, as well as community, program, classroom, peer, and family influences. (Contains 55 tables and 15 notes.) [For related report, "A Second Year in Head Start: Characteristics and Outcomes of Children Who Entered the Program at Age Three. ACF-OPRE Report", see ED517208.] AU - Moiduddin, Emily AU - Aikens, Nikki AU - Tarullo, Louisa AU - West, Jerry Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 79 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Achievement Rating KW - Student Characteristics KW - Academic Achievement KW - Family Life KW - Student Records KW - Participant Satisfaction KW - Demography KW - Parent School Relationship KW - Child Development KW - Statistical Data KW - Preschool Evaluation KW - Family Environment KW - Annual Reports KW - School Statistics KW - Achievement Gains KW - Educational Environment KW - Individual Differences KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864939754?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - What does 'occupation' represent as an indicator of socioeconomic status?: Exploring occupational prestige and health AN - 853216924; 201100837 AB - The association between socioeconomic status (SES) and health has been widely documented. However, the role of occupation in this association is not clear because occupation is less often used than income and education as an indicator of SES, especially in the United States. This may be caused by the ambiguity in what occupation represents: both health-enhancing resources (e.g., self-affirmation) and health-damaging hazards (e.g., job stress). SES has two aspects: resources and status. While income and education represent resources and imply status, occupational prestige is an explicit indicator of the social status afforded by one's occupation. Using data from the US General Social Survey in 2002 and 2006 (n=3151), we examine whether occupational prestige has a significant association with self-rated health independent from other SES indicators (income, education), occupational categories (e.g., managerial, professional, technical, service), and previously established work-related health determinants (job strain, work place social support, job satisfaction). After all covariates were included in the multiple logistic regression model, higher occupational prestige was associated with lower odds of reporting poor/fair self-rated health. We discuss potential mechanisms through which occupational prestige may impact health. Our findings not only suggest multiple ways that occupation is associated with health, but also highlight the utility of occupational prestige as an SES indicator that explicitly represents social standing. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Fujishiro, Kaori AU - Xu, Jun AU - Gong, Fang AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-15), Cincinnati, Ohio 45226, United States kfujishiro@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 2100 EP - 2107 PB - Elsevier Science, Amsterdam The Netherlands VL - 71 IS - 12 SN - 0277-9536, 0277-9536 KW - USA Socioeconomic status Self-rated health Job strain Job satisfaction Social standing KW - Prestige KW - Socioeconomic Status KW - Health Problems KW - Health KW - Health Care Services KW - Income KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853216924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=What+does+%27occupation%27+represent+as+an+indicator+of+socioeconomic+status%3F%3A+Exploring+occupational+prestige+and+health&rft.au=Fujishiro%2C+Kaori%3BXu%2C+Jun%3BGong%2C+Fang&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2010-12-01&rft.volume=71&rft.issue=12&rft.spage=2100&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2010.09.026 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-02-16 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Socioeconomic Status; Prestige; Health; Income; Health Care Services; Health Problems DO - http://dx.doi.org/10.1016/j.socscimed.2010.09.026 ER - TY - JOUR T1 - Perception of facial emotion in adults with bipolar or unipolar depression and controls AN - 853208996; 201106214 AB - Previous research indicates that patients with depression display deficits in their ability to perceive emotions. However, few studies have used animated facial stimuli or explored sensitivity to facial expressions in depressed individuals. Moreover, limited research is available on facial processing in unipolar versus bipolar depression. In this study, 34 patients with DSM-IV major depressive disorder (MDD), 21 patients with DSM-IV bipolar disorder (BPD) in the depressed phase, and 24 never-depressed controls completed the Emotional Expression Multimorph Task, which presents facial emotions in gradations from neutral to 100% emotional expression (happy, sad, surprised, fearful, angry, and disgusted). Groups were compared in terms of sensitivity and accuracy in identifying emotions. Our preliminary findings suggest that subjects with bipolar depression may have emotional processing abnormalities relative to controls. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Schaefer, Kathryn L AU - Baumann, Jacqueline AU - Rich, Brendan A AU - Luckenbaugh, David A AU - Zarate, Carlos A, Jr AD - Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1229 EP - 1235 PB - Elsevier Ltd, Oxford UK VL - 44 IS - 16 SN - 0022-3956, 0022-3956 KW - Bipolar disorder (BPD) Cognition Facial expression Emotion perception Unipolar depression KW - Depressive personality disorders KW - Sensitivity KW - Emotions KW - Visual processing KW - Facial expressions KW - Bipolar affective disorder KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Perception+of+facial+emotion+in+adults+with+bipolar+or+unipolar+depression+and+controls&rft.au=Schaefer%2C+Kathryn+L%3BBaumann%2C+Jacqueline%3BRich%2C+Brendan+A%3BLuckenbaugh%2C+David+A%3BZarate%2C+Carlos+A%2C+Jr&rft.aulast=Schaefer&rft.aufirst=Kathryn&rft.date=2010-12-01&rft.volume=44&rft.issue=16&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.04.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Emotions; Facial expressions; Sensitivity; Depressive personality disorders; Visual processing DO - http://dx.doi.org/10.1016/j.jpsychires.2010.04.024 ER - TY - JOUR T1 - Buprenorphine: A Guide for Nurses (Technical Assistance Publication) AN - 853207790; 201104882 AB - Nurses working in opioid treatment programs (OTPs) and office-based community settings have essential roles in the assessment, screening, treatment monitoring and counseling of patients receiving buprenorphine for the treatment of opioid addiction. However, challenges to implementing buprenorphine treatment with patients addicted to opioids or other drugs, including medication diversion and confidentiality issues, require nurses to improve their professional skills and prepare themselves for the implementation of best practices in addiction settings. Recent studies have found that inconsistency between science and practice is often attributed to inadequate staff education and training. Nurses working in addiction settings have reported, on an ongoing basis, attending very few clinical trainings in the area of substance abuse. This guide highlights the addiction management skills of nurses and promotes a mutually respectful team environment in which nurses and physicians collaboratively work to improve the care provided to opioid addicted individuals, including assessment, induction, stabilization, maintenance, monitoring, addiction counseling and relapse prevention services. It also serves as a resource to help nurses working with community/office based physicians to improve treatment outcomes for individuals receiving office-based treatment for opioid addiction. Adapted from the source document. JF - Journal of Addictions Nursing AU - Azimi-Bolourian, Sara AU - Fornili, Katherine AD - SAMHSA, CSAT/DPT, 1 Choke Cherry Road, Rockville, MD, 20853 sara.azimi-bolourian@samhsa.hhs.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 183 EP - 186 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 21 IS - 4 SN - 1088-4602, 1088-4602 KW - Addiction Awareness/ Prevention/ Screening/ Education Co-occurring Disorders Substance Abuse Substance Use Disorder KW - Buprenorphine KW - Doctors KW - Counselling KW - Nurses KW - Opioids KW - Addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictions+Nursing&rft.atitle=Buprenorphine%3A+A+Guide+for+Nurses+%28Technical+Assistance+Publication%29&rft.au=Azimi-Bolourian%2C+Sara%3BFornili%2C+Katherine&rft.aulast=Azimi-Bolourian&rft.aufirst=Sara&rft.date=2010-12-01&rft.volume=21&rft.issue=4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictions+Nursing&rft.issn=10884602&rft_id=info:doi/10.3109%2F10884601003628146 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Addiction; Opioids; Buprenorphine; Doctors; Counselling DO - http://dx.doi.org/10.3109/10884601003628146 ER - TY - JOUR T1 - CHECKING THE FOUNDATION: RECENT RADIOBIOLOGY AND THE LINEAR NO-THRESHOLD THEORY AN - 839707225; 14092160 AB - The linear no-threshold (LNT) theory has been adopted as the foundation of radiation protection standards and risk estimation for several decades. The "microdosimetric argument" has been offered in support of the LNT theory. This argument postulates that energy is deposited in critical cellular targets by radiation in a linear fashion across all doses down to zero, and that this in turn implies a linear relationship between dose and biological effect across all doses. This paper examines whether the microdosimetric argument holds at the lowest levels of biological organization following low dose, low dose-rate exposures to ionizing radiation. The assumptions of the microdosimetric argument are evaluated in light of recent radiobiological studies on radiation damage in biological molecules and cellular and tissue level responses to radiation damage. There is strong evidence that radiation initially deposits energy in biological molecules (e.g., DNA) in a linear fashion, and that this energy deposition results in various forms of prompt DNA damage that may be produced in a pattern that is distinct from endogenous (e.g., oxidative) damage. However, a large and rapidly growing body of radiobiological evidence indicates that cell and tissue level responses to this damage, particularly at low doses and/or dose-rates, are nonlinear and may exhibit thresholds. To the extent that responses observed at lower levels of biological organization in vitro are predictive of carcinogenesis observed in vivo, this evidence directly contradicts the assumptions upon which the microdosimetric argument is based. JF - Health Physics AU - Ulsh, BA AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop C-46, Cincinnati, OH 45226, USA, bau6@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 747 EP - 758 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 6 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - biological effects KW - Ionizing radiation KW - Carcinogenesis KW - DNA KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839707225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=CHECKING+THE+FOUNDATION%3A+RECENT+RADIOBIOLOGY+AND+THE+LINEAR+NO-THRESHOLD+THEORY&rft.au=Ulsh%2C+BA&rft.aulast=Ulsh&rft.aufirst=BA&rft.date=2010-12-01&rft.volume=99&rft.issue=6&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181e32477 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - biological effects; Ionizing radiation; Carcinogenesis; DNA DO - http://dx.doi.org/10.1097/HP.0b013e3181e32477 ER - TY - JOUR T1 - Payment Reform AN - 839570354; 201101342 AB - A discussion of Medicare and Medicaid payment reform. Adapted from the source document. JF - Health Services Research AU - Fraser, Irene AU - Encinosa, William AU - Baker, Laurence AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1847 EP - 1853 PB - Blackwell Publishers, Oxford UK VL - 45 IS - 6p2 SN - 0017-9124, 0017-9124 KW - Medicare KW - Medicaid KW - Payments KW - Reforms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Payment+Reform&rft.au=Fraser%2C+Irene%3BEncinosa%2C+William%3BBaker%2C+Laurence&rft.aulast=Fraser&rft.aufirst=Irene&rft.date=2010-12-01&rft.volume=45&rft.issue=6p2&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2010.01208.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Reforms; Payments; Medicaid; Medicare DO - http://dx.doi.org/10.1111/j.1475-6773.2010.01208.x ER - TY - JOUR T1 - Melamine toxicity--stones vs. crystals. AN - 815965970; 20721654 JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Reimschuessel, Renate AU - Puschner, Birgit AD - Center For Veterinary Medicine, FDA, Office of Research, 8401 Muirkirk Road, 20708, Laurel, MD, USA. renate.reimschuessel@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 468 EP - 9; discussion 470 VL - 6 IS - 4 KW - Triazines KW - 0 KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Infant KW - Animals, Domestic KW - Animals KW - Infant Formula KW - Animal Feed KW - Humans KW - Infant, Newborn KW - Food Contamination KW - Animals, Laboratory KW - China KW - Crystallization KW - Kidney Calculi -- chemically induced KW - Kidney Calculi -- veterinary KW - Triazines -- poisoning KW - Triazines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815965970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Difference+in+expression+of+hepatic+microRNAs+miR-29c%2C+miR-34a%2C+miR-155%2C+and+miR-200b+is+associated+with+strain-specific+susceptibility+to+dietary+nonalcoholic+steatohepatitis+in+mice.&rft.au=Pogribny%2C+Igor+P%3BStarlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BRoss%2C+Sharon+A%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-01&rft.volume=90&rft.issue=10&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2010.113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-12 N1 - Date created - 2010-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Med Toxicol. 2010 Mar;6(1):50-5 [20195812] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s13181-010-0107-5 ER - TY - JOUR T1 - Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. AN - 815962884; 20798247 AB - Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important health concern of welding fume (WF) exposure is neurological dysfunction akin to Parkinson's disease (PD), thought to be mediated by manganese (Mn) in the fumes. Also, there is a proposition that welding might accelerate the onset of PD. Our recent findings link the presence of Mn in the WF with dopaminergic neurotoxicity seen in rats exposed to manual metal arc-hard surfacing (MMA-HS) or gas metal arc-mild steel (GMA-MS) fumes. To elucidate the molecular mechanisms further, we investigated the association of PD-linked (Park) genes and mitochondrial function in causing dopaminergic abnormality. Repeated instillations of the two fumes at doses that mimic ∼1 to 5 yr of worker exposure resulted in selective brain accumulation of Mn. This accumulation caused impairment of mitochondrial function and loss of tyrosine hydroxylase (TH) protein, indicative of dopaminergic injury. A fascinating finding was the altered expression of Parkin (Park2), Uchl1 (Park5), and Dj1 (Park7) proteins in dopaminergic brain areas. A similar regimen of manganese chloride (MnCl(2)) also caused extensive loss of striatal TH, mitochondrial electron transport components, and Park proteins. As mutations in PARK genes have been linked to early-onset PD in humans, and because welding is implicated as a risk factor for parkinsonism, PARK genes might play a critical role in WF-mediated dopaminergic dysfunction. Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Wirth, Oliver AU - Hayashi, Yusuke AU - Krajnak, Kristine M AU - Soukup, Joleen M AU - Ghio, Andrew J AU - Reynolds, Steven H AU - Castranova, Vincent AU - Munson, Albert E AU - Antonini, James M AD - Toxicology and Molecular Biology Branch, Mailstop L-3014, CDC-NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 4989 EP - 5002 VL - 24 IS - 12 KW - Air Pollutants, Occupational KW - 0 KW - Chlorides KW - Manganese Compounds KW - Manganese KW - 42Z2K6ZL8P KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - UCHL1 protein, rat KW - EC 3.4.19.12 KW - Ubiquitin Thiolesterase KW - manganese chloride KW - QQE170PANO KW - Index Medicus KW - Chlorides -- toxicity KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Air Pollutants, Occupational -- toxicity KW - Rats KW - Polymerase Chain Reaction KW - Blotting, Western KW - Rats, Sprague-Dawley KW - Ubiquitin Thiolesterase -- metabolism KW - Ubiquitin Thiolesterase -- genetics KW - Tyrosine 3-Monooxygenase -- genetics KW - Ubiquitin-Protein Ligases -- genetics KW - Occupational Exposure -- adverse effects KW - Ubiquitin-Protein Ligases -- metabolism KW - Male KW - Inhalation Exposure -- adverse effects KW - Parkinson Disease -- etiology KW - Manganese -- metabolism KW - Parkinson Disease -- metabolism KW - Welding KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815962884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Mitochondrial+dysfunction+and+loss+of+Parkinson%27s+disease-linked+proteins+contribute+to+neurotoxicity+of+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BWirth%2C+Oliver%3BHayashi%2C+Yusuke%3BKrajnak%2C+Kristine+M%3BSoukup%2C+Joleen+M%3BGhio%2C+Andrew+J%3BReynolds%2C+Steven+H%3BCastranova%2C+Vincent%3BMunson%2C+Albert+E%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2010-12-01&rft.volume=24&rft.issue=12&rft.spage=4989&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-163964 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-04 N1 - Date created - 2010-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-163964 ER - TY - JOUR T1 - In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes. AN - 812136073; 20637298 AB - The ΦX174 transgenic mouse was first developed as an in vivo Ames test, detecting base pair substitution (bps) at a single bp in a reversion assay. A forward mutational assay was also developed, which is a gain of function assay that also detects bps exclusively. Later work with both assays focused on establishing that a mutation was fixed in vivo using single-burst analysis: determining the number of mutant progeny virus from an electroporated cell by dividing the culture into aliquots before scoring mutants. We review results obtained from single-burst analysis, including testing the hypothesis that high mutant frequencies (MFs) of G:C to A:T mutation recovered by transgenic targets include significant numbers of unrepaired G:T mismatches. Comparison between the ΦX174 and lacI transgenes in mouse spleen indicates that the spontaneous bps mutation frequency per nucleotide (mf(n)) is not significantly lower for ΦX174 than for lacI; the response to ENU is also comparable. For the lacI transgene, the spontaneous bps mf(n) is highly age-dependent up to 12 weeks of age and the linear trend extrapolates at conception to a frequency close to the human bps mf(n) per generation of 1.7 × 10(-8). Unexpectedly, we found that the lacI somatic (spleen) bps mf(n) per cell division at early ages was estimated to be the same as for the human germ-line. The bps mf(n) in bone marrow for the gpt transgene is comparable to spleen for the lacI and ΦX174 transgenes. We conclude that the G:C to A:T transition is characteristic of spontaneous in vivo mutation and that the MFs measured in these transgenes at early ages reflect the expected accumulation of in vivo mutation typical of endogenous mammalian mutation rates. However, spontaneous and induced mf(n)s per nucleotide for the cII gene in spleen are 5-10 times higher than for these other transgenes. Published by Elsevier B.V. JF - Mutation research AU - Valentine, Carrie R AU - Delongchamp, Robert R AU - Pearce, Mason G AU - Rainey, Heather F AU - Dobrovolsky, Vasily N AU - Malling, Heinrich V AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-120, Jefferson, AR 72079, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 205 EP - 216 VL - 705 IS - 3 SN - 0027-5107, 0027-5107 KW - Lac Repressors KW - 0 KW - Index Medicus KW - Animals KW - Spleen -- metabolism KW - Genetic Techniques KW - Models, Genetic KW - Humans KW - Mice KW - Lac Repressors -- genetics KW - Time Factors KW - Mutation KW - Germ Cells -- cytology KW - DNA Mutational Analysis KW - Transgenes KW - Bacteriophage phi X 174 -- genetics KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812136073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=In+vivo+mutation+analysis+using+the+%CE%A6X174+transgenic+mouse+and+comparisons+with+other+transgenes+and+endogenous+genes.&rft.au=Valentine%2C+Carrie+R%3BDelongchamp%2C+Robert+R%3BPearce%2C+Mason+G%3BRainey%2C+Heather+F%3BDobrovolsky%2C+Vasily+N%3BMalling%2C+Heinrich+V%3BHeflich%2C+Robert+H&rft.aulast=Valentine&rft.aufirst=Carrie&rft.date=2010-12-01&rft.volume=705&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrrev.2010.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-03 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrrev.2010.07.001 ER - TY - JOUR T1 - Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. AN - 760237405; 20804780 AB - The primary objective of this study was to determine and characterize surrogate biomarkers that can predict nephrotoxicity induced by mercuric chloride (HgCl₂) using urinary proton nuclear magnetic resonance (¹H NMR) spectral data. A procedure for (1)H NMR urinalysis using pattern recognition was proposed to evaluate nephrotoxicity induced by HgCl₂ in Sprague-Dawley rats. HgCl₂ at 0.1 or 0.75 mg/kg was administered intraperitoneally (i.p.), and urine was collected every 24 h for 6 days. Animals (n=6 per group) were sacrificed 3 or 6 days post-dosing in order to perform clinical blood chemistry tests and histopathologic examinations. Urinary ¹H NMR spectroscopy revealed apparent differential clustering between the control and HgCl₂ treatment groups as evidenced by principal component analysis (PCA) and partial least square (PLS)-discriminant analysis (DA). Time- and dose-dependent separation of HgCl₂-treated animals from controls was observed by PCA of ¹H NMR spectral data. In HgCl₂-treated rats, the concentrations of endogenous urinary metabolites of glucose, acetate, alanine, lactate, succinate, and ethanol were significantly increased, whereas the concentrations of 2-oxoglutarate, allantoin, citrate, formate, taurine, and hippurate were significantly decreased. These endogenous metabolites were selected as putative biomarkers for HgCl₂-induced nephrotoxicity. A dose response was observed in concentrations of lactate, acetate, succinate, and ethanol, where severe disruption of the concentrations of 2-oxoglutarate, citrate, formate, glucose, and taurine was observed at the higher dose (0.75 mg/kg) of HgCl₂. Correlation of urinary (1)H NMR PLS-DA data with renal histopathologic changes suggests that ¹H NMR urinalysis can be used to predict or screen for HgCl₂-induced nephrotoxicity. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Kim, Kyu-Bong AU - Um, So Young AU - Chung, Myeon Woo AU - Jung, Seung Chul AU - Oh, Ji Seon AU - Kim, Seon Hwa AU - Na, Han Sung AU - Lee, Byung Mu AU - Choi, Ki Hwan AD - Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul 122-704, Republic of Korea. kyubong@inje.ac.kr Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 114 EP - 126 VL - 249 IS - 2 KW - Biomarkers KW - 0 KW - Mercuric Chloride KW - 53GH7MZT1R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Biomarkers -- urine KW - Time Factors KW - Metabolomics KW - Male KW - Magnetic Resonance Spectroscopy KW - Mercuric Chloride -- urine KW - Mercuric Chloride -- blood KW - Acute Kidney Injury -- chemically induced KW - Mercuric Chloride -- toxicity KW - Acute Kidney Injury -- blood KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760237405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Toxicometabolomics+approach+to+urinary+biomarkers+for+mercuric+chloride+%28HgCl%E2%82%82%29-induced+nephrotoxicity+using+proton+nuclear+magnetic+resonance+%28%C2%B9H+NMR%29+in+rats.&rft.au=Kim%2C+Kyu-Bong%3BUm%2C+So+Young%3BChung%2C+Myeon+Woo%3BJung%2C+Seung+Chul%3BOh%2C+Ji+Seon%3BKim%2C+Seon+Hwa%3BNa%2C+Han+Sung%3BLee%2C+Byung+Mu%3BChoi%2C+Ki+Hwan&rft.aulast=Kim&rft.aufirst=Kyu-Bong&rft.date=2010-12-01&rft.volume=249&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2010.08.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-24 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2010.08.017 ER - TY - JOUR T1 - The potential impact of light emitting diode lighting on reducing mining injuries during operation and maintenance of lighting systems AN - 760216739; 13667980 AB - Research by the US National Institute for Occupational Safety and Health (NIOSH) indicates that light emitting diodes (LEDs) can be used to enhance safety by improving a miner's ability to see mining hazards and reducing glare. This paper investigates if LEDs provide another benefit by reducing miner exposure to hazards during maintenance and operation of LED lighting. LEDs could provide useful lives up to 50 times longer than incandescent lighting commonly used in mining and could enable design changes to reduce certain hazards. The mining accident records compiled by the Mine Safety and Health Administration (MSHA) were examined to determine the extent and nature of accidents involving the maintenance and operation of mine luminaries. A total of 140 relevant accident records were found for the years 2002-2006. These incidents resulted in 3668days lost from work with an additional 925days of restricted activity. The injury narratives were studied to determine if the implementation of LED-based luminaries could reduce injury severity and frequency. The greatest near-term potential impacts appear to be related to reducing maintenance and cap lamp redesign. Longer term (5years), low-power and lightweight auxiliary LED lighting for surface mines could also have potential impact for improving safety. JF - Safety Science AU - Yenchek, Michael R AU - Sammarco, John J AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA, mby5@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1380 EP - 1386 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 48 IS - 10 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Illumination KW - Light emitting diode KW - Safety KW - Mining KW - Accidents KW - safety engineering KW - Safety regulations KW - Injuries KW - Occupational safety KW - Lighting KW - Mines KW - Maintenance KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760216739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=The+potential+impact+of+light+emitting+diode+lighting+on+reducing+mining+injuries+during+operation+and+maintenance+of+lighting+systems&rft.au=Yenchek%2C+Michael+R%3BSammarco%2C+John+J&rft.aulast=Yenchek&rft.aufirst=Michael&rft.date=2010-12-01&rft.volume=48&rft.issue=10&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2010.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Accidents; Safety regulations; safety engineering; Injuries; Occupational safety; Lighting; Mining; Mines; Maintenance DO - http://dx.doi.org/10.1016/j.ssci.2010.05.011 ER - TY - JOUR T1 - Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects. AN - 757177194; 20925447 AB - The development of novel engineered nano-sized materials is a rapidly emerging technology with many applications in medicine and industry. In vitro and in vivo studies have suggested many deleterious effects of carbon nanotube exposure including granulomatous inflammation, release of cytosolic enzymes, pulmonary fibrosis, reactive oxygen damage, cellular atypia, DNA fragmentation, mutation and errors in chromosome number as well as mitotic spindle disruption. The physical properties of the carbon nanotubes make respiratory exposure to workers likely during the production or use of commercial products. Many of the investigations of the genotoxicity of carbon nanotubes have focused on reactive oxygen mediated DNA damage; however, the long thin tubular-shaped carbon nanotubes have a striking similarity to cellular microtubules. The similarity of carbon nanotubes to microtubules suggests a potential to interact with cellular biomolecules, such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. Disruption of centrosomes and mitotic spindles would result in monopolar, tripolar, and quadrapolar divisions of chromosomes. The resulting aneuploidy is a key mechanism in the potential carcinogenicity of carbon nanotubes. JF - Nanotoxicology AU - Sargent, Linda M AU - Reynolds, Steven H AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia 26505, USA. LSargent@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 396 EP - 408 VL - 4 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Animals KW - Mutagenicity Tests -- methods KW - Particle Size KW - Humans KW - Cell Line, Tumor KW - Nanotubes, Carbon -- chemistry KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757177194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Potential+pulmonary+effects+of+engineered+carbon+nanotubes%3A+in+vitro+genotoxic+effects.&rft.au=Sargent%2C+Linda+M%3BReynolds%2C+Steven+H%3BCastranova%2C+Vincent&rft.aulast=Sargent&rft.aufirst=Linda&rft.date=2010-12-01&rft.volume=4&rft.issue=&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.500444 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-19 N1 - Date created - 2010-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.500444 ER - TY - JOUR T1 - Brominated and Chlorinated Flame Retardants: The San Antonio Statement AN - 1677922325; 14160346 AB - Abstract not available. JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Bergman, Aake AD - Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina birnbaumls@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - A514 EP - A515 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Flame retardants KW - Bromination KW - Health KW - Chlorination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677922325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Brominated+and+Chlorinated+Flame+Retardants%3A+The+San+Antonio+Statement&rft.au=Birnbaum%2C+Linda+S%3BBergman%2C+Aake&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-12-01&rft.volume=118&rft.issue=2&rft.spage=A514&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1003088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-10-04 DO - http://dx.doi.org/10.1289/ehp.1003088 ER - TY - GEN T1 - The Head Start Child Development and Early Learning Framework: Promoting Positive Outcomes in Early Childhood Programs Serving Children 3-5 Years Old AN - 1651854718; ED547179 AB - This report presents a revision of the Head Start Child Outcomes Framework (2000), renamed The Head Start Child Development and Learning Framework: Promoting Positive Outcomes in Early Childhood Programs Serving Children 3-5 Years Old. The Framework outlines the essential areas of development and learning that are to be used by Head Start programs to establish school readiness goals for their children, monitor children's progress, align curricula, and conduct program planning. It can be used to guide curriculum, implementation, and assessment to plan teaching and learning experiences that align to school readiness goals and track children's progress across developmental domains. The Framework is organized into 11 Domains, 37 Domain Elements, and over 100 Examples. The domains and domain elements are organized in a similar way to the original Framework to facilitate a transition to the revised one. The changes to the revised Framework are designed to provide more clarity to the domains and domain elements of the original Framework and do not create new requirements for Head Start grantees. The early childhood field has changed dramatically. The population of children served by Head Start and other early childhood programs continues to grow more diverse. New research has improved the Office of Head Start's understanding of school readiness, and the Improving Head Start for School Readiness Act of 2007 has increased the Framework's role in Head Start programs. In addition, almost every state now has early learning standards. Also, new reporting systems have emerged at the state level and through the Office of Special Education Programs (OSEP) within the U.S. Department of Education. The Framework is revised in light of these realities. [This report was prepared by the Head Start Resource Center.] Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 28 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Thinking Skills KW - Language Acquisition KW - Child Health KW - Student Diversity KW - Health Education KW - Mathematics Skills KW - Bilingualism KW - Preschool Curriculum KW - Self Concept KW - Disabilities KW - Federal Programs KW - Child Development KW - Alignment (Education) KW - Disadvantaged Youth KW - Social Development KW - Science Achievement KW - Literacy KW - Interpersonal Relationship KW - Preschool Children KW - School Readiness KW - Learning Strategies KW - Progress Monitoring KW - Low Income Groups KW - Educational Legislation KW - Social Studies KW - Physical Development KW - Emotional Development KW - Federal Legislation KW - English Language Learners KW - Receptive Language KW - Expressive Language KW - Self Efficacy KW - Psychomotor Skills KW - Art Activities KW - State Standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1651854718?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Population dynamics of Vibrio spp. associated with marine sponge microcosms AN - 1038594304; 16969341 AB - Vibrio is a diverse genus of marine-associated bacteria with at least 74 species and more expected as additional marine ecospheres are interrogated. This report describes a phylogenetic reconstruction of Vibrio isolates derived from one such unique ecosystem, marine sponges (Phylum Porifera) collected from depths of 150 to 1242 feet. 16S rRNA gene sequencing along with molecular typing of 16S-23S rRNA intergenic spacer regions clustered many sponge-associated Vibrio (spp) with current known species. That is, several benthic Vibrio species commensal with Porifera sponges seemed genetically linked to vibrios associated with coastal or shallow-water communities, signalling a panmictic population structure among seemingly ecologically disparate strains. Conversely, phylogenetic analysis provided evidence for at least two novel Vibrio speciation events within this specific sponge microcosm. Collectively, these findings earmark this still relatively unknown environment as a bastion of taxonomic and phylogenetic variability for the genus and probably other bacterial taxa. JF - ISME Journal AU - Hoffmann, Maria AU - Fischer, Markus AU - Ottesen, Andrea AU - McCarthy, Peter J AU - Lopez, Jose V AU - Brown, Eric W AU - Monday, Steven R AD - 1] Division of Microbiology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Paint Branch Parkway, College Park, MD, USA [2] Department of Chemistry, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, Hamburg, Germany Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1608 EP - 1612 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 4 IS - 12 SN - 1751-7362, 1751-7362 KW - Microbiology Abstracts B: Bacteriology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Phylogeny KW - Marine KW - Speciation KW - Porifera KW - Commensals KW - Population dynamics KW - rRNA KW - Vibrio KW - Spacer region KW - Community composition KW - Typing KW - Shallow water KW - Population structure KW - Taxonomy KW - Microcosms KW - rRNA 16S KW - Phylogenetics KW - J 02310:Genetics & Taxonomy KW - O 5080:Legal/Governmental KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038594304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISME+Journal&rft.atitle=Population+dynamics+of+Vibrio+spp.+associated+with+marine+sponge+microcosms&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BOttesen%2C+Andrea%3BMcCarthy%2C+Peter+J%3BLopez%2C+Jose+V%3BBrown%2C+Eric+W%3BMonday%2C+Steven+R&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-12-01&rft.volume=4&rft.issue=12&rft.spage=1608&rft.isbn=&rft.btitle=&rft.title=ISME+Journal&rft.issn=17517362&rft_id=info:doi/10.1038%2Fismej.2010.85 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Community composition; Shallow water; Commensals; Taxonomy; Population structure; Microcosms; Population dynamics; Phylogenetics; Phylogeny; rRNA; Speciation; Spacer region; Typing; rRNA 16S; Vibrio; Porifera; Marine DO - http://dx.doi.org/10.1038/ismej.2010.85 ER - TY - JOUR T1 - Interpreting Screening Questionnaires Specific Respiratory Symptoms and Their Relationship to Objective Test Results AN - 1020835896; 14292382 AB - Objective: To better delineate the relationship between responses to screening respiratory symptom questionnaires and various pulmonary function test results. Methods: Spirometry, methacholine challenge, standardized questionnaires, smoking, medical, and work histories were recorded at initial and 5-year follow-up surveys among 411 participants. Percent-predicted forced expiratory volume in 1 second (ppFEV sub(1)), 5-year FEV sub(1) decline, and proportion of methacholine responders (% hyper-responders) were compared with questionnaire responses utilizing generalized estimating equations modeling and analysis of variance. Results: Significant associations were found between ppFEV sub(1) and cough, phlegm, dyspnea, or ever wheezing; between greater percentage of hyper-responders and dyspnea with wheezing, ever/persistent wheezing, or history of asthma/hay fever; and between accelerated FEV sub(1) decline and new onset dyspnea with wheezing, phlegm, or persistent wheeze. Conclusions: Particular respiratory symptoms reported on screening questionnaires are associated with specific physiologic abnormalities, enhancing questionnaire utility in workplace health surveillance. JF - Journal of Occupational and Environmental Medicine AU - Petsonk, EL AU - Wang, M L AD - NIOSH, Mail Stop H-G900.2, 1095 Willowdale Road, Morgantown, WV 26505, USA, elp2@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1225 EP - 1229 VL - 52 IS - 12 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Asthma KW - Historical account KW - Respiratory diseases KW - Respiratory function KW - Smoking KW - Standards KW - hay fever KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020835896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Interpreting+Screening+Questionnaires+Specific+Respiratory+Symptoms+and+Their+Relationship+to+Objective+Test+Results&rft.au=Petsonk%2C+EL%3BWang%2C+M+L&rft.aulast=Petsonk&rft.aufirst=EL&rft.date=2010-12-01&rft.volume=52&rft.issue=12&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181fd728f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Smoking; Historical account; hay fever; Asthma; Standards; Respiratory function; Respiratory diseases DO - http://dx.doi.org/10.1097/JOM.0b013e3181fd728f ER - TY - JOUR T1 - Exposure to flour dust and sensitization among bakery employees AN - 1017966700; 16691605 AB - Background The National Institute for Occupational Safety and Health conducted a study to determine prevalences of sensitization to bakery-associated antigens (BAAs) and work-related respiratory symptoms at a large commercial bakery. Methods The following measurements were carried out: personal breathing zone (PBZ) and general area (GA) monitoring for inhalable flour dust, -amylase and wheat, a questionnaire, and blood tests for IgE specific to flour dust, wheat, -amylase, and common aeroallergens. Results Of 186 bakery employees present during our site visit, 161completed the questionnaire and 96 allowed their blood to be drawn. The geometric mean PBZ and GA inhalable flour dust concentrations for the lower-exposure group was 0.235 mg/m3, and for the higher-exposure group was 3.01 mg/m3. Employees in the higher-exposure group had significantly higher prevalences of work-related wheezing, runny nose, stuffy nose, and frequent sneezing than the lower-exposure group. The prevalence of IgE specific to wheat was significantly higher among employees who ever had a job in the higher-exposure group or in production at another bakery at both the >= 0.10 kU/L and the >= 0.35 kU/L cutoffs, and to flour dust and -amylase at the >= 0.10 kU/L cutoff, compared to the lower-exposure group. Conclusions Despite knowledge of the risks of exposure to flour being available for centuries, U.S. employees are still at risk of sensitization and respiratory symptoms from exposure to high levels of BAA. Am. J. Ind. Med. 53:1225-1232, 2010. ? 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Page, Elena H AU - Dowell Cih, Chad H AU - Mueller, Charles A AU - Biagini, Raymond E AU - Heederik, Dick AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, epage@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1225 EP - 1232 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 12 SN - 1097-0274, 1097-0274 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - wheat KW - Inhalation KW - Inventories KW - Respiration KW - Occupational safety KW - Wheezing KW - Dust KW - Triticum aestivum KW - Blood KW - USA KW - Immunoglobulin E KW - Allergens KW - Nose KW - Flour KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Exposure+to+flour+dust+and+sensitization+among+bakery+employees&rft.au=Page%2C+Elena+H%3BDowell+Cih%2C+Chad+H%3BMueller%2C+Charles+A%3BBiagini%2C+Raymond+E%3BHeederik%2C+Dick&rft.aulast=Page&rft.aufirst=Elena&rft.date=2010-12-01&rft.volume=53&rft.issue=12&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20893 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20893/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Inventories; Blood; Respiration; Allergens; Immunoglobulin E; Wheezing; Nose; Flour; Dust; Inhalation; wheat; Occupational safety; Triticum aestivum; USA DO - http://dx.doi.org/10.1002/ajim.20893 ER - TY - JOUR T1 - Effect of vaginal progesterone, administered to prevent preterm birth, on impedance to blood flow in fetal and uterine circulation AN - 1017962455; 16703937 AB - Objective To evaluate the effect on the maternal and fetal circulation of progesterone administered to prevent preterm birth. Methods We used an observational cohort study design. The study group included 44 women at 18-32 weeks' gestation who presented with an episode of preterm labor, with or without history of delivery before 34 weeks' gestation, or an incidental finding of short cervix (<= 25 mm). Doppler flow assessment of the umbilical artery, fetal middle cerebral artery and uterine arteries was performed before and 24 h after vaginal administration of progesterone. Results Seventeen (38.6%) women gave birth before term, but only nine (20.4%) did so before 34 weeks' gestation. Following progesterone treatment, there was a statistically significant decrease in the pulsatility index of the fetal middle cerebral artery (mean reduction, 18.2%; mean change in pulsatility index, 0.44 (95% CI, 0.25-0.63), P < 0.001), with no changes in the other vessels. Comparison of the women who gave birth before with those who delivered at term yielded no significant differences in Doppler flow parameters in any vessel examined, either before or after progesterone treatment. Conclusion Treatment with vaginal progesterone is associated with a lower pulsatility index in the fetal middle cerebral artery, suggesting a vasodilatory effect on the fetal circulation. JF - Ultrasound in Obstetrics and Gynecology AU - Barda, G AU - Ben-Haroush, A AU - Barkat, J AU - Malinger, G AU - Luria, O AU - Golan, A AU - Bar, J AD - Maternal-Fetal Medicine Unit, Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel, jbar@wolfson.health.gov.il Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 743 EP - 748 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 6 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Cervix KW - Fetuses KW - Gestation KW - Gynecology KW - Obstetrics KW - Progesterone KW - Statistical analysis KW - Ultrasound KW - Uterus KW - Vagina KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Effect+of+vaginal+progesterone%2C+administered+to+prevent+preterm+birth%2C+on+impedance+to+blood+flow+in+fetal+and+uterine+circulation&rft.au=Barda%2C+G%3BBen-Haroush%2C+A%3BBarkat%2C+J%3BMalinger%2C+G%3BLuria%2C+O%3BGolan%2C+A%3BBar%2C+J&rft.aulast=Barda&rft.aufirst=G&rft.date=2010-12-01&rft.volume=36&rft.issue=6&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.7606 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.7606/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Birth; Uterus; Gynecology; Progesterone; Vagina; Gestation; Statistical analysis; Cervix; Obstetrics; Ultrasound; Fetuses DO - http://dx.doi.org/10.1002/uog.7606 ER - TY - JOUR T1 - Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection AN - 851464652; 14023714 AB - A high-pressure liquid chromatography-diode array detection and multi-mode ionization tandem mass spectrometry (HPLC-DAD-MMI-MS/MS) method was used to identify amino-tadalafil and rimonabant in electronic cigarette (e-cigarette) cartridges. Amino-tadalafil is a drug analogue of the commercially approved Cialis[TM] (i.e. tadalafil). Rimonabant is a drug that was, at one time, approved for weight loss in Europe (although approval has been retracted), but not in the United States. In addition, poor quality control over the e-cigarette products analyzed here is shown by the presence of nicotine in products labeled as containing no nicotine or by the presence of significant amounts of rimonabant oxidative degradant in e-cigarette products containing rimonabant. Identification was accomplished by comparing the retention time of relevant peaks in the sample with those of standard compounds, in addition to comparison of the UV spectra, mass spectra and/or product ion mass spectra. JF - Journal of Chromatography A AU - Hadwiger, Michael E AU - Trehy, Michael L AU - Ye, Wei AU - Moore, Terry AU - Allgire, James AU - Westenberger, Benjamin AD - Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St., Saint Louis, MO 63101, USA, michael.hadwiger@fda.hhs.gov Y1 - 2010/11/26/ PY - 2010 DA - 2010 Nov 26 SP - 7547 EP - 7555 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 48 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - E-cigarettes KW - Electronic cigarettes KW - HPLC KW - Mass spectrometry KW - Multi-mode ionization KW - MS KW - Rimonabant KW - Amino-tadalafil KW - Mass Spectrometry KW - Cigarettes KW - Chromatographic techniques KW - Europe KW - Mass spectroscopy KW - Mass Spectra KW - Weight KW - Nicotine KW - Ultraviolet radiation KW - Pressure KW - Quality Control KW - Drugs KW - Retention Time KW - USA KW - Liquid chromatography KW - Quality control KW - High Pressure KW - Standards KW - Ionization KW - SW 5010:Network design KW - X 24380:Social Poisons & Drug Abuse KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851464652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Identification+of+amino-tadalafil+and+rimonabant+in+electronic+cigarette+products+using+high+pressure+liquid+chromatography+with+diode+array+and+tandem+mass+spectrometric+detection&rft.au=Fang%2C+Hong%3BXu%2C+Joshua%3BDing%2C+Don%3BJackson%2C+Scott+A%3BPatel%2C+Isha+R%3BFrye%2C+Jonathan+G%3BZou%2C+Wen%3BNayak%2C+Rajesh%3BFoley%2C+Steven%3BChen%2C+James%3BSu%2C+Zhenqiang%3BYe%2C+Yanbin%3BTurner%2C+Steve%3BHarris%2C+Steve%3BZhou%2C+Guangxu%3BCerniglia%2C+Carl%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Quality control; Ultraviolet radiation; Pressure; Drugs; Cigarettes; Liquid chromatography; Nicotine; Mass spectroscopy; Mass Spectrometry; Weight; Mass Spectra; Retention Time; High Pressure; Standards; Quality Control; Ionization; USA; Europe DO - http://dx.doi.org/10.1016/j.chroma.2010.10.018 ER - TY - JOUR T1 - Second Malignancy Risks After Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia: Differences by Lymphoma Subtype AN - 954606480; 14104669 AB - PURPOSE: Previous studies have shown increased risks of second malignancies after non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL); however, no earlier investigation has quantified differences in risk of new malignancy by lymphoma subtype. PATIENTS AND METHODS: We evaluated second cancer and leukemia risks among 43,145 1-year survivors of CLL/small lymphocytic lymphoma (SLL), diffuse large B-cell lymphoma (DLBCL), or follicular lymphoma (FL) from 11 Surveillance, Epidemiology, and End Results (SEER) population-based registries during 1992 to 2006. RESULTS: Among patients without HIV/AIDS-related lymphoma, lung cancer risks were significantly elevated after CLL/SLL and FL but not after DLBCL (standardized incidence ratio [SIR], CLL/SLL = 1.42, FL = 1.28, DLBCL = 1.00; Poisson regression P for difference among subtypes, PDiff = .001). A similar pattern was observed for risk of cutaneous melanoma (SIR: CLL/SLL = 1.92, FL = 1.60, DLBCL = 1.06; PDiff = .004). Acute nonlymphocytic leukemia risks were significantly elevated after FL and DLBCL, particularly among patients receiving initial chemotherapy, but not after CLL/SLL (SIR: CLL/SLL = 1.13, FL = 5.96, DLBCL = 4.96; PDiff < .001). Patients with HIV/AIDS-related lymphoma (n = 932) were predominantly diagnosed with DLBCL and had significantly and substantially elevated risks for second anal cancer (SIR = 120.50) and Kaposi's sarcoma (SIR = 138.90). CONCLUSION: Our findings suggest that differing immunologic alterations, treatments (eg, alkylating agent chemotherapy), genetic susceptibilities, and other risk factors (eg, viral infections, tobacco use) among lymphoma subtypes contribute to the patterns of second malignancy risk. Elucidating these patterns may provide etiologic clues to lymphoma as well as to the second malignancies. JF - Journal of Clinical Oncology AU - Morton, Lindsay M AU - Curtis, Rochelle E AU - Linet, Martha S AU - Bluhm, Elizabeth C AU - Tucker, Margaret A AU - Caporaso, Neil AU - Ries, Lynn AG AU - Fraumeni, Joseph F AD - From the Divisions of Cancer Epidemiology and Genetics, Rockville, MD, and of Cancer Control and Population Sciences, Bethesda, MD, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Y1 - 2010/11/20/ PY - 2010 DA - 2010 Nov 20 SP - 4935 EP - 4944 PB - American Society of Clinical Oncology VL - 28 IS - 33 SN - 0732-183X, 0732-183X KW - Immunology Abstracts; Toxicology Abstracts KW - Alkylating agents KW - B-cell lymphoma KW - double prime B-cell lymphoma KW - Chemotherapy KW - Melanoma KW - Non-Hodgkin's lymphoma KW - Malignancy KW - Epidemiology KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - Risk factors KW - Tobacco KW - Chronic lymphatic leukemia KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954606480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Second+Malignancy+Risks+After+Non-Hodgkin%27s+Lymphoma+and+Chronic+Lymphocytic+Leukemia%3A+Differences+by+Lymphoma+Subtype&rft.au=Morton%2C+Lindsay+M%3BCurtis%2C+Rochelle+E%3BLinet%2C+Martha+S%3BBluhm%2C+Elizabeth+C%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil%3BRies%2C+Lynn+AG%3BFraumeni%2C+Joseph+F&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2010-11-20&rft.volume=28&rft.issue=33&rft.spage=4935&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Alkylating agents; B-cell lymphoma; double prime B-cell lymphoma; Chemotherapy; Melanoma; Non-Hodgkin's lymphoma; Malignancy; Kaposi's sarcoma; Epidemiology; Risk factors; Tobacco; Chronic lymphatic leukemia; Lung cancer; Human immunodeficiency virus ER - TY - JOUR T1 - Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species AN - 849478017; 14025552 AB - Welding fumes consist of a wide range of complex metal oxide particles which can be deposited in all regions of the respiratory tract. The welding aerosol is not homogeneous and is generated mostly from the electrode/wire. Over 390,000 welders were reported in the U.S. in 2008 while over 1 million full-time welders were working worldwide. Many health effects are presently under investigation from exposure to welding fumes. Welding fume pulmonary effects have been associated with bronchitis, metal fume fever, cancer and functional changes in the lung. Our investigation focused on the generation of free radicals and reactive oxygen species from stainless and mild steel welding fumes generated by a gas metal arc robotic welder. An inhalation exposure chamber located at NIOSH was used to collect the welding fume particles. Our results show that hydroxyl radicals (.OH) were generated from reactions with H2O2 and after exposure to cells. Catalase reduced the generation of .OH from exposed cells indicating the involvement of H2O2. The welding fume suspension also showed the ability to cause lipid peroxidation, effect O2 consumption, induce H2O2 generation in cells, and cause DNA damage. Increase in oxidative damage observed in the cellular exposures correlated well with .OH generation in size and type of welding fumes, indicating the influence of metal type and transition state on radical production as well as associated damage. Our results demonstrate that both types of welding fumes are able to generate ROS and ROS-related damage over a range of particle sizes; however, the stainless steel fumes consistently showed a significantly higher reactivity and radical generation capacity. The chemical composition of the steel had a significant impact on the ROS generation capacity with the stainless steel containing Cr and Ni causing more damage than the mild steel. Our results suggest that welding fumes may cause acute lung injury. Since type of fume generated, particle size, and elapsed time after generation of the welding exposure are significant factors in radical generation and particle deposition these factors should be considered when developing protective strategies. JF - Particle and Fibre Toxicology AU - Leonard, Stephen S AU - Chen, Bean T AU - Stone, Samuel G AU - Schwegler-Berry, Diane AU - Kenyon, Allison J AU - Frazer, David AU - Antonini, James M AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2010/11/03/ PY - 2010 DA - 2010 Nov 03 SP - 32 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Inhalation KW - Injuries KW - Fever KW - Reactive oxygen species KW - Hydrogen peroxide KW - Welding KW - oxides KW - Bronchitis KW - Steel KW - Respiratory tract KW - Particle size KW - Metals KW - Aerosols KW - Fumes KW - Chromium KW - Free radicals KW - Catalase KW - Cancer KW - Lipid peroxidation KW - DNA damage KW - Lung KW - Electrodes KW - robotics KW - stainless steel KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849478017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Comparison+of+stainless+and+mild+steel+welding+fumes+in+generation+of+reactive+oxygen+species&rft.au=Leonard%2C+Stephen+S%3BChen%2C+Bean+T%3BStone%2C+Samuel+G%3BSchwegler-Berry%2C+Diane%3BKenyon%2C+Allison+J%3BFrazer%2C+David%3BAntonini%2C+James+M&rft.aulast=Leonard&rft.aufirst=Stephen&rft.date=2010-11-03&rft.volume=7&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-32 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inhalation; Particle size; Metals; Aerosols; Fumes; Injuries; Chromium; Free radicals; Lipid peroxidation; Cancer; Catalase; Fever; DNA damage; Reactive oxygen species; Lung; Hydrogen peroxide; Electrodes; oxides; Welding; robotics; Bronchitis; Steel; stainless steel; Respiratory tract DO - http://dx.doi.org/10.1186/1743-8977-7-32 ER - TY - JOUR T1 - Concentration of metals in blood of Maine children 1-6 years old AN - 954606231; 14164371 AB - Blood lead concentrations are higher in young children than in other age groups, whereas little is known regarding concentrations of other metals in young children. We measured the concentrations of a suite of metals in the blood of children 1-6 years of age, and assessed potential differences by age, season, or region of Maine. We used blood submitted to the Maine State Health and Environmental Testing Laboratory for blood lead analysis to determine the concentrations of arsenic (As), antimony (Sb), cadmium (Cd), manganese (Mn), mercury (Hg), selenium (Se), tin (Sn), and uranium (U) in 1350 children 1-6 years of age. The essential metals Mn and Se were detected in all samples, and As and Sb were detected in >90% of samples. Hg was detected in approximately 60% of samples. U and Cd were less often detected in blood samples, at approximately 30% and 10% of samples, respectively. Sn was not detected in any sample. Concentrations of As, Hg, and Se increased with age, whereas Sb decreased with age. Concentrations also varied by season and region for some though not all metals. Significant pairwise correlations were observed for a number of metals. Blood is a reasonable compartment for measurement of most of these metals in young children. The use of convenience samples provided a cost-effective mechanism for assessing exposure of young children in Maine. JF - Journal of Exposure Science and Environmental Epidemiology AU - Rice, Deborah C AU - Lincoln, Rebecca AU - Martha, John AU - Parker, Lisa AU - Pote, Kenneth AU - Xing, Shuqin AU - Smith, Andrew E AD - Department of Health and Human Services, Environmental and Occupational Health Programs, Maine Center for Disease Control, Augusta, Maine, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 634 EP - 643 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 7 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts KW - Age KW - Heavy metals KW - Lead KW - Selenium KW - Uranium KW - Economics KW - Cadmium KW - Manganese KW - Metals KW - Arsenic KW - Children KW - Blood levels KW - Antimony KW - Mercury KW - USA, Maine KW - Tin KW - X 24390:Radioactive Materials KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954606231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Concentration+of+metals+in+blood+of+Maine+children+1-6+years+old&rft.au=Rice%2C+Deborah+C%3BLincoln%2C+Rebecca%3BMartha%2C+John%3BParker%2C+Lisa%3BPote%2C+Kenneth%3BXing%2C+Shuqin%3BSmith%2C+Andrew+E&rft.aulast=Rice&rft.aufirst=Deborah&rft.date=2010-11-01&rft.volume=20&rft.issue=7&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2010.42 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Selenium; Arsenic; Age; Heavy metals; Uranium; Antimony; Mercury; Cadmium; Tin; Children; Manganese; Lead; Metals; Economics; Blood levels; USA, Maine DO - http://dx.doi.org/10.1038/jes.2010.42 ER - TY - JOUR T1 - Pharmacogenomics and adverse drug reactions AN - 954603521; 14030346 AB - Adverse drug reactions (ADRs) observed during drug development have been the cause for discontinuing development of many drugs. In addition, serious but rare ADRs observed after marketing have led to withdrawal of some drugs. A priori identification of individuals at risk of developing ADRs for a given drug will help develop strategies to reduce the risk for ADRs in these patients. US FDA initiatives and efforts at reducing ADRs to make drugs safer are described, including updating of drug labels to include genomic information intended to reduce ADRs. Pharmacogenomics can also be harnessed to identify individuals at risk of developing serious ADRs and to treat these individuals with alternative therapy, thus converting ADRs that are traditionally considered unavoidable to avoidable ADRs. JF - Personalized Medicine AU - Amur, Shashi AU - Zineh, Issam AU - Abernethy, Darrell R AU - Huang, Shiew-Mei AU - Lesko, Lawrence J AD - super(1)Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Building 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 633 EP - 642 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB UK VL - 7 IS - 6 SN - 1741-0541, 1741-0541 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - pharmacogenomics KW - Drug development KW - genomics KW - Drugs KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Pharmacogenomics+and+adverse+drug+reactions&rft.au=Amur%2C+Shashi%3BZineh%2C+Issam%3BAbernethy%2C+Darrell+R%3BHuang%2C+Shiew-Mei%3BLesko%2C+Lawrence+J&rft.aulast=Amur&rft.aufirst=Shashi&rft.date=2010-11-01&rft.volume=7&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/10.2217%2Fpme.10.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - pharmacogenomics; Drug development; genomics; Drugs DO - http://dx.doi.org/10.2217/pme.10.63 ER - TY - JOUR T1 - Edited by Peter M. Chapman, William J. Adams, Marjorie L. Brooks, Charles G. Delos, Samuel N. Luoma, William A. Maher, Harry M. Ohlendorf, Theresa S. Presser and D. Patrick Shaw, Ecological assessment of selenium in the aquatic environment, CRC Press, New York, 2010, 339 pp., (hardback) ISBN 978-1-4398-2677-5 AN - 883026682; 15241932 AB - Selenium is a naturally occurring essential element. Its concentration in the environment is increasing in the modern industrial world. Selenium can be a double-edged sword; it is not only beneficial for health, but also it can have adverse health effects. This book provides an in-depth ecological assessment of selenium in the aquatic environment. This comprehensive presentation with up-to-date information is the outcome of current developments in selenium research area. JF - Journal of Applied Toxicology AU - Us, Saura C Sahu Y1 - 2010/11// PY - 2010 DA - Nov 2010 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 8 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Edited+by+Peter+M.+Chapman%2C+William+J.+Adams%2C+Marjorie+L.+Brooks%2C+Charles+G.+Delos%2C+Samuel+N.+Luoma%2C+William+A.+Maher%2C+Harry+M.+Ohlendorf%2C+Theresa+S.+Presser+and+D.+Patrick+Shaw%2C+Ecological+assessment+of+selenium+in+the+aquatic+environment%2C+CRC+Press%2C+New+York%2C+2010%2C+339+pp.%2C+%28hardback%29+ISBN+978-1-4398-2677-5&rft.au=Us%2C+Saura+C+Sahu&rft.aulast=Us&rft.aufirst=Saura+C&rft.date=2010-11-01&rft.volume=30&rft.issue=8&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1568 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1568/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/jat.1568 ER - TY - RPRT T1 - FOREWORD AN - 878892486 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878892485 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 3,3',4,4'-TETRACHLOROAZOBENZENE (TCAB) [CAS NO. 14047-09-7] IN HARLAN SPRAGUE-DAWLEY RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878892484; 21383777 AB - 3,3',4,4' Tetrachloroazobenzene (TCAB) is formed as a by-product in the manufacture of a variety of herbicides. TCAB is structurally similar to TCDD, one of a large family of hydrocarbons containing chlorine known as dioxins. We studied the effects of TCAB on male and female rats and mice to identify potential toxic or carcinogenic hazards. We exposed groups of 50 male or female rats by depositing solutions of TCAB dissolved in corn oil through a tube directly into their stomachs five days a week for two years. Daily doses of TCDD were 10, 30, or 100 milligrams (mg) per kilogram of body weight. Similar groups of male or female mice received doses of 3, 10, or 30 mg/kg on the same schedule. Animals receiving corn oil alone served as the control group. Tissues from more than 40 sites were examined for every animal. Exposure to TCAB caused a variety of diseases in several organs. Cancers of the liver, lung, and mouth were seen in both male and female rats. Male rats also had increased rates of thyroid gland tumors and some female rats had tumors of the forestomach. Almost all exposed male mice developed carcinomas of the urethra. Both male and female mice also had a variety of tumors of the lung as well as cancers of the forestomach. Female mice also experienced cancers of the skin. A variety of other toxic effects were observed in exposed animals. In rats these included hypertrophy, hyperplasia, fibrosis, and necrosis of the liver; hyperplasia of the oral mucosa; metaplasia of the lung; inflammation and atrophy of the pancreas; and other nonneoplastic lesions of the forestomach, adrenal cortex, blood vessel, spleen, and mesenteric lymph node. In mice observed adverse outcomes included cardiomyopathy of the heart; atrophy of the thymus; hyperplasia of the skin, urinary bladder, forestomach and glandular stomach; and other nonneoplastic lesions of the spleen, liver, urethra, ureter, blood vessel, clitoral gland, ovary, and bone marrow. We conclude that TCAB caused cancer and other toxic effects at several sites in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 EP - 206 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Azo Compounds KW - Chlorobenzenes KW - 3,4,3',4'-tetrachloroazobenzene KW - By products KW - Toxicology KW - Carcinogens KW - Health hazards KW - Rodents KW - Herbicides KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Humans KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Organ Size -- drug effects KW - Chlorobenzenes -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Azo Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+3%2C3%27%2C4%2C4%27-TETRACHLOROAZOBENZENE+%28TCAB%29+%5BCAS+NO.+14047-09-7%5D+IN+HARLAN+SPRAGUE-DAWLEY+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683498 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683495 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 3 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,3',4,4',5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) AN - 878683472; 21383778 AB - 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) is one of a large family of hydrocarbons containing chlorine (PCBs) that are similar in structure to dioxins. Some dioxins or dioxin-like compounds are highly toxic and cause cancer, and usually contaminated sites contain many different varieties of these dioxin-like compounds. The National Toxicology Program conducted a series of studies to try to gauge the relative toxicity of some of the more prevalent of these compounds, both alone and in mixtures. This study evaluated the effects of PCB 118 on female rats for comparison with the potency of other chemicals in that family. We exposed groups of 50 female rats by depositing solutions of PCB 118 dissolved in corn oil through a tube directly into their stomachs 5 days a week for 2 years. Daily doses of PCB 118 were 100, 220, 460, 1,000, or 4,600 micrograms (µg) per kilogram of body weight. Tissues from more than 40 sites were examined for every animal. Exposure to PCB 118 caused a variety of diseases in several organs. Cancers of the liver, lung, uterus, and pancreas were seen in female rats exposed to PCB 118. A variety of other toxic lesions observed in exposed animals included hypertrophy, hyperplasia, fibrosis, and toxic hepatopathy of the liver, metaplasia of the lung, atrophy of the adrenal cortex, inflammation and cytoplasmic vacuolization of the pancreas, and hypertrophy of the thyroid gland. We conclude that PCB 118 caused cancer of the liver, lung, and uterus and possibly of the pancreas plus a variety of other toxic effects at several sites in female rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 EP - 174 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - 2,3',4,4',5-pentachlorobiphenyl KW - Polychlorinated Biphenyls KW - Tetrachlorodibenzodioxin KW - Hydrocarbons KW - Polychlorinated biphenyls--PCB KW - Toxicology KW - Rodents KW - Cancer KW - Tetrachlorodibenzodioxin -- toxicity KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Polychlorinated Biphenyls -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+2%2C3%27%2C4%2C4%27%2C5-PENTACHLOROBIPHENYL+%28PCB+118%29+%28CAS+NO.+31508-00-6%29+IN+FEMALE+HARLAN+SPRAGUE-DAWLEY+RATS+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Stochastic modeling of gob gas venthole production performances in active and completed longwall panels of coal mines AN - 877845290; 2011-058210 AB - Gob gas ventholes (GGVs) are an integral part of longwall coal mining operations, enhancing safety by controlling methane in underground workings. As in many disciplines in earth sciences, uncertainties due to the heterogeneity of geologic formations exist. These uncertainties, and the wide range of mining and venthole operation parameters, lead to performance variability in GGVs. Random variations in parameters affecting GGV performance and influencing parameters that cannot be quantified sufficiently due to lack of information limit deterministic GGV models and even introduce error in severe cases. Therefore, evaluation of GGV performance data and the uncertainty in input parameters is valuable for understanding the variability in GGV production and for designing them accordingly. This paper describes a practical approach for implementing stochastic determination of GGV production performances and for generalizing the prediction capability of deterministic models. Deterministic site-specific models were derived by using the GGV module in the recently developed MCP (Methane Control and Prediction) software suite. These models were generated using multi-parameter regression techniques and were then improved by inclusion of extra input parameters that eliminated the site dependency and improved the predictions. Statistical distributions of input parameters in these models were quantified and tested with the Kolmogorov-Smirnov goodness-of-fit technique. Next, Monte Carlo simulations were performed using these distributions and generalized results for GGV performances were generated. The results of this work indicate that this approach is a promising method of representing the variability in GGV performances and to improve the limited and site-specific character of the deterministic models. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Luxbacher, Kray Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 125 EP - 140 PB - Elsevier, Amsterdam VL - 84 IS - 2 SN - 0166-5162, 0166-5162 KW - mining KW - mines KW - underground mining KW - natural gas KW - Monte Carlo analysis KW - statistical analysis KW - data processing KW - coal mines KW - prediction KW - petroleum KW - mathematical models KW - production KW - ventilation KW - longwall mining KW - stochastic processes KW - digital simulation KW - coalbed methane KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877845290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Stochastic+modeling+of+gob+gas+venthole+production+performances+in+active+and+completed+longwall+panels+of+coal+mines&rft.au=Karacan%2C+C+Ozgen%3BLuxbacher%2C+Kray&rft.aulast=Karacan&rft.aufirst=C&rft.date=2010-11-01&rft.volume=84&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.09.001 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. 9 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal mines; coalbed methane; data processing; digital simulation; longwall mining; mathematical models; mines; mining; Monte Carlo analysis; natural gas; petroleum; prediction; production; statistical analysis; stochastic processes; underground mining; ventilation DO - http://dx.doi.org/10.1016/j.coal.2010.09.001 ER - TY - JOUR T1 - Measurement of multiple drugs in urine, water, and on surfaces using fluorescence covalent microbead immunosorbent assay AN - 874193062; 14972706 AB - There are a range of applications that require the measurement of multiple drugs such as urine analysis, drug determination in water, and screening for drug contamination on surfaces. Some of the procedures used such as enzyme-linked immunosorbent assay (ELISA) are simple but can only determine one drug at a time, and others such as GC-MS or LC-MS are complex, time-consuming, and expensive. In this study, fluorescence covalent microbead immunosorbent assay (FCMIA) was investigated as a simple method for the measurement of multiple drugs simultaneously in three matrices: diluted urine, water, and on surfaces. Five different drugs of abuse or their metabolites (methamphetamine, caffeine, benzoylecgonine (a metabolite of cocaine), tetrahydrocannabinol (THC), the active ingredient in marijuana, and oxycodone) were studied over the range 0-15 ng/ml. There was no measureable cross-reactivity among the drugs at the concentrations studied. Urine dilutions from 1/50 to 1/2.5 were studied and dilutions less than 1/20 had a significant effect on the methamphetamine assay but limited effects on the benzoylecgonine and oxycodone assays and almost no effect on the THC assay. For assays performed in 1/20 urine dilution, water, and diluted surface sampling buffer, least detectable doses (LDD) were 1 ng/ml or less for the drugs. Surfaces spiked with drugs were sampled with swabs wetted with surface sampling buffer and recoveries were linear over the range 0-100 ng/100 cm super(2) surface loading for all drugs. FCMIA has potential to be used for the measurement of multiple drugs in the matrices studied. JF - Toxicology Mechanisms and Methods AU - Smith, J AU - Sammons, D AU - Robertson, S AU - Biagini, R AU - Snawder, J AD - Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA, jps3@cdc.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 587 EP - 593 VL - 20 IS - 9 SN - 1537-6516, 1537-6516 KW - Environment Abstracts; Toxicology Abstracts KW - Cross-reactivity KW - Contamination KW - Surface water KW - buffers KW - Metabolites KW - oxycodone KW - Drug abuse KW - Drug screening KW - Immunosorbents KW - Cannabis KW - Caffeine KW - Sampling KW - Cocaine KW - Drugs KW - methamphetamine KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - cocaine KW - Tetrahydrocannabinol KW - Methamphetamine KW - Urine KW - microspheres KW - Immunoassays KW - X 24380:Social Poisons & Drug Abuse KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874193062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Measurement+of+multiple+drugs+in+urine%2C+water%2C+and+on+surfaces+using+fluorescence+covalent+microbead+immunosorbent+assay&rft.au=Smith%2C+J%3BSammons%2C+D%3BRobertson%2C+S%3BBiagini%2C+R%3BSnawder%2C+J&rft.aulast=Smith&rft.aufirst=J&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518172 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Fluorescence; Cross-reactivity; Contamination; Metabolites; Drug screening; Drug abuse; oxycodone; Immunosorbents; Tetrahydrocannabinol; Methamphetamine; Urine; microspheres; Cannabis; Caffeine; Sampling; Cocaine; Surface water; cocaine; buffers; Immunoassays; Drugs; methamphetamine DO - http://dx.doi.org/10.3109/15376516.2010.518172 ER - TY - JOUR T1 - Partition coefficients for nonane and its isomers in the rat AN - 874190796; 14972707 AB - Jet Fuel 8 (JP-8) is a major fuel source used by US and NATO military. JP-8 is a complex mixture of aliphatic and aromatic isomers of hydrocarbons. Tissue/blood partition coefficient (PC) values are chemical-specific parameters used in modeling the kinetic behavior of chemicals. The partition coefficient values for n-alkanes tend to increase with the increasing carbon number, but less is known about the trend for isomers of n-alkanes. PC values were obtained for the n-alkane nonane (C9) and five of its isomers, namely 3-methyloctane, 4-ethylheptane, 2, 3-dimethylheptane, 2, 2, 4-trimethylhexane, 2, 2, 4, 4-tetramethylpentane. The blood:air and tissue:air PC values correlated with the published log octanol/water (O:W) PC values for n-nonane and its isomers. Experimentally determined blood:air and tissue:air PC values for n-nonane with the largest O:W value were greatest and smallest for the isomer 2, 2, 4, 4-tetramethylpentane with the lowest O:W value. As expected the fat tissue had the highest PC values and muscle the lowest for n-nonane and its isomers. For each tissue, a linear relationship was observed between the tissue/blood PC values for the isomers of n-nonane and n-nonane. This suggests that tissue/blood PC values for all isomers of an alkane could be estimated using data collected from only a sub-set of alkanes of equal carbon number. These reported tissue/blood PC values will support the development of a jet fuel physiologically-based pharmacokinetic (PBPK) model. JF - Toxicology Mechanisms and Methods AU - Joshi, G AU - Tremblay, R T AU - Martin, SA AU - Fisher, J W AD - FDA/NCTR, 3900 NCTR Road, Jefferson, AR, USA, jeffrey.fisher@hhs.fda.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 594 EP - 599 VL - 20 IS - 9 SN - 1537-6516, 1537-6516 KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Fuels KW - Models KW - Isomers KW - Carbon KW - octanol KW - Military KW - Alkanes KW - Data processing KW - Hydrocarbons KW - Muscles KW - N-Alkanes KW - Pharmacokinetics KW - Blood KW - Kinetics KW - aromatic hydrocarbons KW - Aromatics KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874190796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Partition+coefficients+for+nonane+and+its+isomers+in+the+rat&rft.au=Joshi%2C+G%3BTremblay%2C+R+T%3BMartin%2C+SA%3BFisher%2C+J+W&rft.aulast=Joshi&rft.aufirst=G&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alkanes; Data processing; Hydrocarbons; Fuels; Muscles; N-Alkanes; Pharmacokinetics; Isomers; Models; Blood; Carbon; octanol; Kinetics; Aromatics; Chemicals; Military; aromatic hydrocarbons DO - http://dx.doi.org/10.3109/15376516.2010.518175 ER - TY - JOUR T1 - The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone AN - 864953652; 13932401 AB - Mitoquinone (MitoQ) is a synthetically modified, redox-active ubiquinone compound that accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible inhibition of clonogenic growth of breast cancer cells through a combination of autophagy and apoptotic cell death mechanisms. Relatively limited cytotoxicity was seen with the parent ubiquinone coenzyme Q sub(10.) Inhibition of cancer cell growth by MitoQ was associated with G sub(1)/S cell cycle arrest and phosphorylation of the checkpoint kinases Chk1 and Chk2. The possible role of oxidative stress in MitoQ activity was investigated by measuring the products of hydroethidine oxidation. Increases in ethidium and dihydroethidium levels, markers of one-electron oxidation of hydroethidine, were observed at cytotoxic concentrations of MitoQ. Keap1, an oxidative stress sensor protein that regulates the antioxidant transcription factor Nrf2, underwent oxidation, degradation, and dissociation from Nrf2 in MitoQ-treated cells. Nrf2 protein levels, nuclear localization, and transcriptional activity also increased following MitoQ treatment. Knockdown of Nrf2 caused a 2-fold increase in autophagy and an increase in G sub(1) cell cycle arrest in response to MitoQ but had no apparent effect on apoptosis. The Nrf2-regulated enzyme NQO1 is partly responsible for controlling the level of autophagy. Keap1 and Nrf2 act as redox sensors for oxidative perturbations that lead to autophagy. MitoQ and similar compounds should be further evaluated for novel anticancer activity. JF - Journal of Biological Chemistry AU - Rao, VAshutosh AU - Klein, Sarah R AU - Bonar, Spencer J AU - Zielonka, Jacek AU - Mizuno, Naoko AU - Dickey, Jennifer S AU - Keller, Paul W AU - Joseph, Joy AU - Kalyanaraman, Balaraman AU - Shacter, Emily AD - Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 34447 EP - 34459. PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 45 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - CHK2 protein KW - Antioxidants KW - Apoptosis KW - Cell cycle KW - Enzymes KW - Mitochondria KW - NRF2 protein KW - Coenzyme Q10 KW - Cytotoxicity KW - Phosphorylation KW - ubiquinone KW - Oxidative stress KW - Transcription factors KW - Breast cancer KW - NAD(P)H dehydrogenase (quinone) KW - CHK1 protein KW - Phagocytosis KW - Antitumor activity KW - N 14835:Protein-Nucleic Acids Association KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864953652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Antioxidant+Transcription+Factor+Nrf2+Negatively+Regulates+Autophagy+and+Growth+Arrest+Induced+by+the+Anticancer+Redox+Agent+Mitoquinone&rft.au=Rao%2C+VAshutosh%3BKlein%2C+Sarah+R%3BBonar%2C+Spencer+J%3BZielonka%2C+Jacek%3BMizuno%2C+Naoko%3BDickey%2C+Jennifer+S%3BKeller%2C+Paul+W%3BJoseph%2C+Joy%3BKalyanaraman%2C+Balaraman%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=VAshutosh&rft.date=2010-11-01&rft.volume=285&rft.issue=45&rft.spage=34447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.133579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - CHK2 protein; Apoptosis; Antioxidants; Cell cycle; NRF2 protein; Mitochondria; Enzymes; Coenzyme Q10; Cytotoxicity; Phosphorylation; Oxidative stress; ubiquinone; Transcription factors; Breast cancer; CHK1 protein; NAD(P)H dehydrogenase (quinone); Phagocytosis; Antitumor activity DO - http://dx.doi.org/10.1074/jbc.M110.133579 ER - TY - JOUR T1 - Unhealthy and Uninsured: Exploring Racial Differences in Health and Health Insurance Coverage Using A Life Table Approach AN - 856405082; 201108185 AB - Millions of people in the United States do not have health insurance, and wide racial and ethnic disparities exist in coverage. Current research provides a limited description of this problem, focusing on the number or proportion of individuals without insurance at a single time point or for a short period. Moreover, the literature provides no sense of the joint risk of being uninsured and in need of medical care. In this article, we use a life table approach to calculate health- and insurance-specific life expectancies for whites and blacks, thereby providing estimates of the duration of exposure to different insurance and health states over a typical lifetime. We find that, on average, Americans can expect to spend well over a decade without health insurance during a typical lifetime and that 40% of these years are spent in less-healthy categories. Findings also reveal a significant racial gap: despite their shorter overall life expectancy, blacks have a longer uninsured life expectancy than whites, and this racial gap consists entirely of less-healthy years. Racial disparities in insurance coverage are thus likely more severe than indicated by previous research. Adapted from the source document. JF - Demography AU - Kirby, James B AU - Kaneda, Toshiko AD - The Agency for Healthcare Research and Quality, Center for Financing, Access, and Cost Trends, 540 Gaither Road, Rockville, MD 20850 jkirby@ahrq.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1035 EP - 1051 PB - Population Association of America, Silver Spring MD VL - 47 IS - 4 SN - 0070-3370, 0070-3370 KW - Life Tables KW - Health Insurance KW - Health Problems KW - United States of America KW - Racial Differences KW - Longevity KW - article KW - 1837: demography and human biology; demography (population studies) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856405082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Demography&rft.atitle=Unhealthy+and+Uninsured%3A+Exploring+Racial+Differences+in+Health+and+Health+Insurance+Coverage+Using+A+Life+Table+Approach&rft.au=Kirby%2C+James+B%3BKaneda%2C+Toshiko&rft.aulast=Kirby&rft.aufirst=James&rft.date=2010-11-01&rft.volume=47&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Demography&rft.issn=00703370&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2011-03-07 N1 - Number of references - 56 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Insurance; Longevity; Racial Differences; Life Tables; Health Problems; United States of America ER - TY - JOUR T1 - Multiple Antigen Peptide Vaccines against Plasmodium falciparum Malaria AN - 853475925; 13885345 AB - The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antigenic epitopes from the sporozoite, liver, and blood stages of the life cycle. Antibody and cellular responses were determined in three inbred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice. All three MAPs were immunogenic and induced both antibody and cellular responses, albeit in a somewhat genetically restricted manner. Antibodies against MAP-1, MAP-2, and MAP-3 had an antiparasite effect that was also dependent on the mouse major histocompatibility complex background. Anti-MAP-1 (CSP-based) antibodies blocked the invasion of HepG2 liver cells by P. falciparum sporozoites (highest, 95.16% in HLA-A2 C57BL/6; lowest, 11.21% in BALB/c). Furthermore, antibodies generated following immunizations with the MAP-2 (PfCSP, PfLSA-1, PfMSP-142, and PfMSP-3b) and MAP-3 (PfRAP-1, PfRAP-2, PfSERA, and PfMSP-142) vaccines were able to reduce the growth of blood stage parasites in erythrocyte cultures to various degrees. Thus, MAP-based vaccines remain a viable option to induce effective antibody and cellular responses. These results warrant further development and preclinical and clinical testing of the next generation of candidate MAP vaccines that are based on the conserved protective epitopes from Plasmodium antigens that are widely recognized by populations of divergent HLA types from around the world. JF - Infection and Immunity AU - Mahajan, Babita AU - Berzofsky, Jay A AU - Boykins, Robert A AU - Majam, Victoria AU - Zheng, Hong AU - Chattopadhyay, Rana AU - la Vega, Patricia de AU - Moch, JKathleen AU - Haynes, JDavid AU - Belyakov, Igor M AD - Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Sanjai.kumar@fda.hhs.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 4613 EP - 4624 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 11 SN - 0019-9567, 0019-9567 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Parasites KW - Hepatocytes KW - Erythrocytes KW - Disease control KW - Life cycle KW - Major histocompatibility complex KW - Cell culture KW - Malaria KW - Public health KW - Antigens KW - Lymphocytes T KW - Epitopes KW - Lymphocytes B KW - Sporozoites KW - Plasmodium falciparum KW - Immunization KW - Blood KW - Antibodies KW - Immunogenicity KW - Liver KW - Inbreeding KW - Peptides KW - Vaccines KW - K 03350:Immunology KW - Q1 08485:Species interactions: pests and control KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853475925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Folotyn+%28pralatrexate+injection%29+for+the+treatment+of+patients+with+relapsed+or+refractory+peripheral+T-cell+lymphoma%3A+U.S.+Food+and+Drug+Administration+drug+approval+summary.&rft.au=Malik%2C+Shakun+M%3BLiu%2C+Ke%3BQiang%2C+Xu%3BSridhara%2C+Rajeshwari%3BTang%2C+Shenghui%3BMcGuinn%2C+W+David%3BVerbois%2C+S+Leigh%3BMarathe%2C+Anshu%3BWilliams%2C+Gene+M%3BBullock%2C+Julie%3BTornoe%2C+Christoffer%3BLin%2C+Sue+Ching%3BOcheltree%2C+Terrance%3BVialpando%2C+Milinda%3BKacuba%2C+Alice%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Malik&rft.aufirst=Shakun&rft.date=2010-10-15&rft.volume=16&rft.issue=20&rft.spage=4921&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-10-1214 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 63 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Antigens; Disease control; Peptides; Vaccines; Public health; Histocompatibility antigen HLA; Lymphocytes B; Hepatocytes; Erythrocytes; Sporozoites; Major histocompatibility complex; Life cycle; Malaria; Cell culture; Immunization; Blood; Immunogenicity; Liver; Lymphocytes T; Inbreeding; Epitopes; Plasmodium falciparum DO - http://dx.doi.org/10.1128/IAI.00533-10 ER - TY - JOUR T1 - Thresholds for nonlinear effects in high- intensity focused ultrasound propagation and tissue heating AN - 849447213; 13916157 AB - For a variety of reasons, including their simplicity and ability to capitalize upon superposition, linear acoustic propagation models are preferable to nonlinear ones in modeling the propagation of high-intensity focused ultrasound (HIFU) beams. However, under certain conditions, nonlinear models are necessary to accurately model the beam propagation and heating. In analyzing the performance of a HIFU system, it is advantageous to know before the analysis whether a linear model suffices. This paper examines the problem of determining the thresholds at which nonlinear effects become important. It is demonstrated that nonlinear interaction has different effects on different physical and derived quantities, such as compressional pressure, rarefactional pressure, intensity, heat rate, temperature rise, and thermal lesion volume. Thresholds are determined as a function of the dimensionless gain, nonlinearity, and absorption parameters. The relative difference between linear and nonlinear predictions is plotted as a series of contours, enabling practicioners to locate their system in parameter space and determine whether nonlinearity significantly affects the quantities of interest. JF - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control AU - Soneson, Joshua E AU - Myers, Matthew R AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 2450 EP - 2459 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 57 IS - 11 SN - 0885-3010, 0885-3010 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Acoustics KW - Ultrasonics KW - nonlinear systems KW - Pressure KW - Ultrasound KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849447213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Ultrasonics%2C+Ferroelectrics+and+Frequency+Control&rft.atitle=Thresholds+for+nonlinear+effects+in+high-+intensity+focused+ultrasound+propagation+and+tissue+heating&rft.au=Soneson%2C+Joshua+E%3BMyers%2C+Matthew+R&rft.aulast=Soneson&rft.aufirst=Joshua&rft.date=2010-11-01&rft.volume=57&rft.issue=11&rft.spage=2450&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Ultrasonics%2C+Ferroelectrics+and+Frequency+Control&rft.issn=08853010&rft_id=info:doi/10.1109%2FTUFFC.2010.1711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ultrasonics; Acoustics; nonlinear systems; Pressure; Ultrasound; Models DO - http://dx.doi.org/10.1109/TUFFC.2010.1711 ER - TY - JOUR T1 - Antioxidants and Pulmonary Function Among Police Officers AN - 839706499; 14029607 AB - Objective: To examine associations of dietary antioxidant intake and pulmonary function. Methods: Antioxidant data (vitamins A, C, D, E, magnesium, and omega-3 fatty acids) were abstracted from food frequency questionnaires. Pulmonary function was measured using American Thoracic Society criteria. We used analysis of variance to investigate associations. Results: Among 79 police officers (57% male), forced vital capacity was positively and significantly associated with vitamin A after adjustment for age, gender, height, race, smoking status, and pack-years of smoking, and with magnesium after adjustment for those risk factors plus total calories, all supplement use, and abdominal height. Among current/former smokers only, mean levels of all pulmonary function measures were significantly associated with vitamin E; smoking status significantly modified these relationships. Conclusions: Increased intake of vitamin A, vitamin E (among current/former smokers only), and magnesium was associated with better pulmonary function. JF - Journal of Occupational and Environmental Medicine AU - Charles, LE AU - Burchfiel, C M AU - Mnatsakanova, A AU - Fekedulegn, D AU - Tinney-Zara, C AU - Joseph, P N AU - Schunemann, HJ AU - Violanti, J M AU - Andrew, ME AU - Ochs-Balcom, H M AD - National Institute for Occupational Safety and Health, HELD/BEB, MailStop L-4050, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA, lcharles@cdc.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1124 EP - 1131 VL - 52 IS - 11 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Diets KW - Antioxidants KW - Smoking KW - vitamins KW - police KW - Gender KW - Fatty acids KW - Respiratory function KW - Magnesium KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839706499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Antioxidants+and+Pulmonary+Function+Among+Police+Officers&rft.au=Charles%2C+LE%3BBurchfiel%2C+C+M%3BMnatsakanova%2C+A%3BFekedulegn%2C+D%3BTinney-Zara%2C+C%3BJoseph%2C+P+N%3BSchunemann%2C+HJ%3BViolanti%2C+J+M%3BAndrew%2C+ME%3BOchs-Balcom%2C+H+M&rft.aulast=Charles&rft.aufirst=LE&rft.date=2010-11-01&rft.volume=52&rft.issue=11&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181f7cb4c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Antioxidants; vitamins; police; Gender; Fatty acids; Respiratory function; Magnesium DO - http://dx.doi.org/10.1097/JOM.0b013e3181f7cb4c ER - TY - JOUR T1 - Detection and confirmation of Clostridium botulinum in water used for cooling at a plant producing low-acid canned foods. AN - 763165490; 20889791 AB - Our laboratory tested water samples used for cooling low-acid canned foods at a canning facility under investigation by the U.S. Food and Drug Administration. We used an enzyme-linked immunosorbent assay with digoxigenin-labeled antibodies (DIG-ELISA) and real-time PCR as screening methods and confirmed the presence of neurotoxin-producing Clostridium botulinum in the samples by mouse bioassay. JF - Applied and environmental microbiology AU - Sachdeva, Amita AU - Defibaugh-Chávez, Stephanie L H AU - Day, James B AU - Zink, Donald AU - Sharma, Shashi K AD - FDA, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 7653 EP - 7657 VL - 76 IS - 22 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - United States KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Botulism -- diagnosis KW - Animals KW - Polymerase Chain Reaction -- methods KW - Bacteriological Techniques -- methods KW - Disease Models, Animal KW - Botulinum Toxins -- biosynthesis KW - Mice KW - Botulism -- pathology KW - Mass Screening -- methods KW - Food, Preserved KW - Clostridium botulinum -- isolation & purification KW - Water Microbiology KW - Food Industry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763165490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Detection+and+confirmation+of+Clostridium+botulinum+in+water+used+for+cooling+at+a+plant+producing+low-acid+canned+foods.&rft.au=Sachdeva%2C+Amita%3BDefibaugh-Ch%C3%A1vez%2C+Stephanie+L+H%3BDay%2C+James+B%3BZink%2C+Donald%3BSharma%2C+Shashi+K&rft.aulast=Sachdeva&rft.aufirst=Amita&rft.date=2010-11-01&rft.volume=76&rft.issue=22&rft.spage=7653&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00820-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-22 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2000 Mar 7;39(9):2399-405 [10694409] J Nat Toxins. 2000 Nov;9(4):357-62 [11126514] J Clin Microbiol. 2004 Apr;42(4):1713-5 [15071029] J Infect Dis. 1981 Jan;143(1):22-7 [7012244] J Clin Microbiol. 1985 Jun;21(6):947-50 [3891773] J Protein Chem. 1995 Jan;14(1):7-18 [7779263] Appl Environ Microbiol. 2006 Feb;72(2):1231-8 [16461671] J Protein Chem. 1998 Jan;17(1):53-60 [9491928] Ann Intern Med. 1998 Aug 1;129(3):221-8 [9696731] Curr Microbiol. 1998 Nov;37(5):312-8 [9767710] J Protein Chem. 1999 Jan;18(1):29-38 [10071926] Foodborne Pathog Dis. 2004 Winter;1(4):247-57 [15992287] Toxicon. 1995 Dec;33(12):1541-7 [8866611] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.00820-10 ER - TY - JOUR T1 - Evaluation of virulence factor profiling in the characterization of veterinary Escherichia coli isolates. AN - 763165458; 20889790 AB - Escherichia coli has been used as an indicator organism for fecal contamination of water and other environments and is often a commensal organism in healthy animals, yet a number of strains can cause disease in young or immunocompromised animals. In this study, 281 E. coli isolates from bovine, porcine, chicken, canine, equine, feline, and other veterinary sources were analyzed by BOXA1R PCR and by virulence factor profiling of 35 factors to determine whether they had utility in identifying the animal source of the isolates. The results of BOXA1R PCR analysis demonstrated a high degree of diversity; less than half of the isolates fell into one of 27 clusters with at least three isolates (based on 90% similarity). Nearly 60% of these clusters contained isolates from more than one animal source. Conversely, the results of virulence factor profiling demonstrated clustering by animal source. Three clusters, named Bovine, Chicken, and Porcine, based on discriminant components analysis, were represented by 90% or more of the respective isolates. A fourth group, termed Companion, was the most diverse, containing at least 84% of isolates from canine, feline, equine, and other animal sources. Based on these results, it appears that virulence factor profiling may have utility, helping identify the likely animal host species sources of certain E. coli isolates. JF - Applied and environmental microbiology AU - David, Donna E AU - Lynne, Aaron M AU - Han, Jing AU - Foley, Steven L AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 7509 EP - 7513 VL - 76 IS - 22 KW - Escherichia coli Proteins KW - 0 KW - Virulence Factors KW - Index Medicus KW - Animals, Domestic KW - Genetic Variation KW - Animals KW - Polymerase Chain Reaction -- methods KW - Bacteriological Techniques -- methods KW - Bacterial Typing Techniques KW - Cluster Analysis KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- veterinary KW - Escherichia coli -- isolation & purification KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Virulence Factors -- genetics KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763165458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Evaluation+of+virulence+factor+profiling+in+the+characterization+of+veterinary+Escherichia+coli+isolates.&rft.au=David%2C+Donna+E%3BLynne%2C+Aaron+M%3BHan%2C+Jing%3BFoley%2C+Steven+L&rft.aulast=David&rft.aufirst=Donna&rft.date=2010-11-01&rft.volume=76&rft.issue=22&rft.spage=7509&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00726-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-22 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 2004 Oct 22-Nov 26;67(20-22):1879-87 [15371222] J Clin Microbiol. 2003 Sep;41(9):4480-2 [12958300] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4641-5 [9539791] J Clin Microbiol. 1999 Jun;37(6):1661-9 [10325304] Epidemiol Infect. 1999 Aug;123(1):17-24 [10487637] Vet Res. 2005 Mar-Apr;36(2):241-56 [15720976] Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5564-9 [15809431] Can J Microbiol. 2005 Jun;51(6):501-5 [16121229] J Microbiol Methods. 2005 Nov;63(2):135-44 [15893395] Appl Environ Microbiol. 2005 Nov;71(11):6753-61 [16269706] Clin Microbiol Infect. 2006 Jul;12(7):634-41 [16774559] PLoS Negl Trop Dis. 2008;2(3):e196 [18335069] Appl Environ Microbiol. 2009 Mar;75(5):1373-80 [19139228] Foodborne Pathog Dis. 2009 Mar;6(2):207-15 [19099358] Water Res. 2010 Mar;44(6):1873-83 [19945729] Appl Environ Microbiol. 2010 Jun;76(11):3744-7 [20400570] Vet Rec. 2010 May 29;166(22):691-2 [20511653] J Vet Med Sci. 2010 May;72(5):589-97 [20103992] J Infect Dis. 2000 Jan;181(1):261-72 [10608775] Avian Dis. 2000 Jan-Mar;44(1):23-33 [10737641] Appl Environ Microbiol. 2000 Jun;66(6):2572-7 [10831440] Vet Microbiol. 2001 Feb 12;78(3):241-9 [11165068] Vet Microbiol. 2001 Oct 1;82(4):311-20 [11506925] Avian Dis. 2002 Apr-Jun;46(2):342-52 [12061643] J Clin Microbiol. 2003 Apr;41(4):1375-85 [12682117] Appl Environ Microbiol. 1992 Dec;58(12):3809-15 [1476425] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.00726-10 ER - TY - JOUR T1 - Pulmonary infections and risk of lung cancer among persons with AIDS. AN - 758835897; 20736841 AB - Lung cancer risk is significantly increased among persons with AIDS (PWA), and increased smoking may not explain all of the elevated risk, suggesting a role for additional cofactors. We investigated whether AIDS-defining pulmonary infections (recurrent pneumonia, Pneumocystis jirovecii pneumonia, and pulmonary tuberculosis) affected the risk of subsequent lung cancer over 10 years after AIDS onset among 322,675 PWA, whose records were linked with cancer registries in 11 US regions. We assessed lung cancer hazard ratios (HRs) using Cox regression and indirectly adjusted HRs for confounding by smoking. Individuals with recurrent pneumonia (n = 5317) were at significantly higher lung cancer risk than those without [HR = 1.63, 95% confidence interval (CI) = 1.08 to 2.46, adjusted for age, race, sex, HIV acquisition mode, CD4 count, and AIDS diagnosis year]. This association was especially strong among young PWA (<50 years HR = 1.99 vs. ≥50 years HR = 1.10) and was significantly elevated during 5-10 years after recurrent pneumonia diagnosis (HR = 2.41; 95% CI = 1.07 to 5.47). Although attenuated, HRs for recurrent pneumonia remained nonsignificantly elevated after indirect adjustment for smoking. Lung cancer risk was unrelated to tuberculosis [(n = 13,878) HR = 1.12, 95% CI = 0.82 to 1.53] or Pneumocystis jirovecii pneumonia [(n = 69,771) HR = 0.97, 95% CI = 0.80 to 1.18]. The increased lung cancer risk associated with recurrent pneumonia supports the hypothesis that chronic pulmonary inflammation arising from infections contributes to lung carcinogenesis. JF - Journal of acquired immune deficiency syndromes (1999) AU - Shebl, Fatma M AU - Engels, Eric A AU - Goedert, James J AU - Chaturvedi, Anil K AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 375 EP - 379 VL - 55 IS - 3 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Acquired Immunodeficiency Syndrome -- complications KW - AIDS-Related Opportunistic Infections -- complications KW - Lung Neoplasms -- epidemiology KW - Tuberculosis, Pulmonary -- complications KW - Pneumonia, Pneumocystis -- complications KW - Pneumonia, Bacterial -- complications KW - AIDS-Related Opportunistic Infections -- microbiology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758835897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Pulmonary+infections+and+risk+of+lung+cancer+among+persons+with+AIDS.&rft.au=Shebl%2C+Fatma+M%3BEngels%2C+Eric+A%3BGoedert%2C+James+J%3BChaturvedi%2C+Anil+K&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-11-01&rft.volume=55&rft.issue=3&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=1944-7884&rft_id=info:doi/10.1097%2FQAI.0b013e3181eef4f7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 2000 Mar 7;132(5):369-72 [10691587] Lung Cancer. 2010 Apr;68(1):20-6 [19545930] Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):612-6 [10934095] Int J Cancer. 2003 May 20;105(1):101-7 [12672038] Am J Epidemiol. 2004 Aug 15;160(4):384-92 [15286024] MMWR Morb Mortal Wkly Rep. 1993 Apr 30;42(16):308-10 [8474424] Am J Epidemiol. 1993 Dec 1;138(11):909-22 [8256779] Am J Epidemiol. 1995 Jun 1;141(11):1023-32 [7771438] N Engl J Med. 1995 Sep 28;333(13):845-51 [7651475] Am J Epidemiol. 1999 Jan 1;149(1):13-20 [9883789] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):773-8 [15824142] Arch Intern Med. 2005 Jul 11;165(13):1533-40 [16009870] J Clin Oncol. 2006 Mar 20;24(9):1383-8 [16549832] Lung Cancer. 2006 Jul;53(1):5-12 [16733074] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] AIDS. 2007 Jan 11;21(2):207-13 [17197812] Arch Intern Med. 2007 Feb 26;167(4):335-42 [17325294] Clin Infect Dis. 2007 Jul 1;45(1):103-10 [17554710] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] Respirology. 2008 Jun;13(4):585-9 [18410259] Int J Cancer. 2009 Mar 1;124(5):1183-7 [19058197] Int J Cancer. 2009 Dec 15;125(12):2936-44 [19521963] Lancet Oncol. 2009 Dec;10(12):1152-9 [19818686] JAMA. 2000 Aug 9;284(6):706-12 [10927778] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAI.0b013e3181eef4f7 ER - TY - JOUR T1 - Ultrastructural analysis of ICP34.5- herpes simplex virus 1 replication in mouse brain cells in vivo. AN - 757177921; 20702618 AB - Replication-competent forms of herpes simplex virus 1 (HSV-1) defective in the viral neurovirulence factor infected cell protein 34.5 (ICP34.5) are under investigation for use in the therapeutic treatment of cancer. In mouse models, intratumoral injection of ICP34.5-defective oncolytic HSVs (oHSVs) has resulted in the infection and lysis of tumor cells, an associated decrease in tumor size, and increased survival times. The ability of these oHSVs to infect and lyse cells is frequently characterized as exclusive to or selective for tumor cells. However, the extent to which ICP34.5-deficient HSV-1 replicates in and may be neurotoxic to normal brain cell types in vivo is poorly understood. Here we report that HSV-1 defective in ICP34.5 expression is capable of establishing a productive infection in at least one normal mouse brain cell type. We show that γ34.5 deletion viruses replicate productively in and induce cellular damage in infected ependymal cells. Further evaluation of the effects of oHSVs on normal brain cells in animal models is needed to enhance our understanding of the risks associated with the use of current and future oHSVs in the brains of clinical trial subjects and to provide information that can be used to create improved oHSVs for future use. JF - Journal of virology AU - Mehta, Hina AU - Muller, Jacqueline AU - Markovitz, Nancy S AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 10982 EP - 10990 VL - 84 IS - 21 KW - Viral Proteins KW - 0 KW - gamma 34.5 protein, Human herpesvirus 1 KW - Index Medicus KW - Virus Replication KW - Herpes Simplex KW - Animals KW - Oncolytic Viruses -- genetics KW - Oncolytic Virotherapy KW - Mice KW - Gene Deletion KW - Viral Proteins -- genetics KW - Herpesvirus 1, Human -- pathogenicity KW - Brain -- pathology KW - Defective Viruses -- pathogenicity KW - Brain -- virology KW - Defective Viruses -- ultrastructure KW - Herpesvirus 1, Human -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757177921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Ultrastructural+analysis+of+ICP34.5-+herpes+simplex+virus+1+replication+in+mouse+brain+cells+in+vivo.&rft.au=Mehta%2C+Hina%3BMuller%2C+Jacqueline%3BMarkovitz%2C+Nancy+S&rft.aulast=Mehta&rft.aufirst=Hina&rft.date=2010-11-01&rft.volume=84&rft.issue=21&rft.spage=10982&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00337-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Apr;74(8):3832-41 [10729157] Neuroscience. 2008 Sep 22;156(1):81-8 [18682279] J Virol. 2004 Jul;78(14):7653-66 [15220440] J Gen Virol. 1968 May;2(3):357-64 [4300104] Cell. 1981 May;24(2):555-65 [6263501] Cell. 1981 Jul;25(1):227-32 [6268303] Virology. 1989 Nov;173(1):276-83 [2554573] Science. 1990 Nov 30;250(4985):1262-6 [2173860] J Gen Virol. 1991 Mar;72 ( Pt 3):631-9 [1848598] J Clin Invest. 1993 Jun;91(6):2837-43 [8390490] Childs Nerv Syst. 1994 Apr;10(3):151-5 [8044808] J Gen Virol. 1994 Dec;75 ( Pt 12):3679-86 [7996163] Glia. 1995 May;14(1):1-13 [7615341] Nat Med. 1995 Sep;1(9):938-43 [7585221] Arch Virol. 1996;141(3-4):505-24 [8645092] Cancer Res. 1997 Apr 15;57(8):1502-9 [9108452] J Virol. 1997 Jul;71(7):5560-9 [9188630] Hum Gene Ther. 1997 Nov 20;8(17):2057-68 [9414254] J Gen Virol. 1998 Mar;79 ( Pt 3):525-36 [9519831] J Virol. 1998 Dec;72(12):9992-10002 [9811737] Cell. 1999 Jan 8;96(1):25-34 [9989494] J Virol. 1999 Oct;73(10):8010-8 [10482549] Brain Res Brain Res Rev. 2005 Apr;48(2):220-33 [15850661] Behav Brain Res. 2005 Sep 8;163(2):227-36 [15990178] J Virol. 2005 Oct;79(20):13047-59 [16189007] J Virol. 2006 Feb;80(3):1610-1; author reply 1611-2 [16415038] Mol Ther. 2006 May;13(5):891-8 [16574492] J Virol. 2006 Jul;80(13):6716-7; author replies 6717-9 [16775362] Cancer Gene Ther. 2006 Nov;13(11):975-92 [16604059] Expert Rev Neurother. 2007 Apr;7(4):321-4 [17425484] Cell Host Microbe. 2007 Mar 15;1(1):23-35 [18005679] Hum Vaccin. 2008 Mar-Apr;4(2):91-105 [18496918] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):190-5 [11756670] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00337-10 ER - TY - JOUR T1 - Challenges in assessing nanomaterial toxicology: a personal perspective. AN - 756663890; 20799267 AB - Nanotechnology exploits the fact that nanoparticles exhibit unique physicochemical properties, which are distinct from fine-sized particles of the same composition. It follows that nanoparticles may also express distinct bioactivity and unique interactions with biological systems. Therefore, it is essential to assess the potential health risks of exposure to nanoparticles to allow development and implementation of prevention measures. Risk assessment requires data concerning hazard and exposure. Several challenges face the field of nanotoxicology in obtaining the necessary data for assessment of the bioactivity of nanoparticles. They include: (1) the vast number of nanoparticle types to be evaluated, (2) the need to use nanoparticle doses and structure sizes in cellular and animal test systems which are relevant to anticipated workplace exposures, and (3) artifactual in vitro results due to absorption of nutrients or assay indicator compounds from the culture media. This 'opinion' reviews the progress made in the field of nanotoxicology in recent years to overcome these challenges. © 2010 John Wiley & Sons, Inc. JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology AU - Geraci, Charles L AU - Castranova, Vincent AD - Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. PY - 2010 SP - 569 EP - 577 VL - 2 IS - 6 KW - Index Medicus KW - Rats KW - Animals KW - Particle Size KW - Humans KW - Mice KW - Cell Line KW - Toxicity Tests -- methods KW - Nanoparticles -- ultrastructure KW - Toxicity Tests -- instrumentation KW - Risk Assessment -- methods KW - Nanoparticles -- toxicity KW - Nanoparticles -- administration & dosage KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756663890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.atitle=Challenges+in+assessing+nanomaterial+toxicology%3A+a+personal+perspective.&rft.au=Geraci%2C+Charles+L%3BCastranova%2C+Vincent&rft.aulast=Geraci&rft.aufirst=Charles&rft.date=2010-11-01&rft.volume=2&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.issn=1939-0041&rft_id=info:doi/10.1002%2Fwnan.108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-24 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/wnan.108 ER - TY - JOUR T1 - Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. AN - 755404437; 20872634 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products, epoxy resin-based food can liners, and paper products. The presence of BPA in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure and is problematic because of the potential for endocrine disruption. The ubiquity of environmental BPA in common laboratory supplies used for sample collection, storage, and analysis greatly increases the likelihood of false positive determinations, particularly at trace levels. The current study validated using liquid chromatography/tandem mass spectrometry (LC/MS/MS) in conjunction with deuterated BPA as the dosing material to circumvent contamination for high sensitivity quantifications in rat serum, tissues, urine, and feces. The methods described provided measurements of both estrogen receptor-active aglycone and metabolically deactivated conjugated forms of BPA, a distinction that is critical to assessing toxicological potential. The adequacy of the described methodology was substantiated by its utility in analyzing samples from rats treated orally with a 100 µg/kg body weight dose of d6-BPA. These results emphasize the challenges inherent in measuring BPA in biological samples and how employing stable isotope labeled dosing can facilitate pharmacokinetic studies needed to understand BPA metabolism and disposition. Such studies conducted in experimental animal models, in conjunction with properly validated human biomonitoring data, will be the basis for PBPK modeling of BPA in environmentally exposed humans. Published in 2010 by John Wiley & Sons, Ltd. JF - Rapid communications in mass spectrometry : RCM AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Vanlandingham, Michelle AU - Doerge, Daniel R AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2010/10/30/ PY - 2010 DA - 2010 Oct 30 SP - 3011 EP - 3020 VL - 24 IS - 20 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - Deuterium KW - AR09D82C7G KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Clinical Laboratory Techniques -- standards KW - Reproducibility of Results KW - Reference Standards KW - Female KW - Chromatography, Liquid -- methods KW - Deuterium -- blood KW - Phenols -- blood KW - Tandem Mass Spectrometry -- methods KW - Phenols -- chemistry KW - Deuterium -- chemistry KW - Deuterium -- analysis KW - Phenols -- urine KW - Feces -- chemistry KW - Phenols -- analysis KW - Deuterium -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755404437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Quantification+of+deuterated+bisphenol+A+in+serum%2C+tissues%2C+and+excreta+from+adult+Sprague-Dawley+rats+using+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Twaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Anastos&rft.aufirst=Kathryn&rft.date=2010-10-20&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013525 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-30 N1 - Date created - 2010-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/rcm.4733 ER - TY - JOUR T1 - Toxicity assessment of pramipexole in juvenile rhesus monkeys AN - 759321279; 13783343 AB - Pramipexole (PPX) is a dopamine agonist approved for the treatment of the signs and symptoms of idiopathic Parkinson's disease as well as restless leg syndrome. The objective of this study was to investigate the toxicity of PPX when administered orally to juvenile rhesus monkeys once daily for 30 weeks, and to assess the reversibility of toxicity during a 12-week recovery. Rhesus monkeys (N=4 males and 4 females/group; 22-24 months of age) were orally treated daily for 30 weeks with 0.0, 0.1, 0.5 or 2.0mg/kg PPX, and subjects were assessed daily using the NCTR Operant Test Battery (OTB). Clinical chemistry, hematology, ophthalmology and other standard postmortem toxicological evaluations, including histopathology and neuropathology as well as toxicokinetics were performed. The systemic exposure to PPX was higher than that at therapeutic doses in man and AUC(0-24h)-data increased proportionally to dose. Blood pressure significantly decreased over time in all groups including control. Near the end of treatment, there were statistically significant decreases in heart rate for the 0.5 and 2.0mg/kg/day groups compared to control. After 4 weeks of dosing, serum prolactin was significantly decreased in all treatment groups compared to control. This decrease remained at the end of treatment in the 0.5 and 2.0mg/kg/day groups. In summary, administration of PPX at doses of up to 2.0mg/kg/day for 30 weeks to juvenile rhesus monkeys produced adverse findings which were attributable to its pharmacological properties, including hypoprolactinemia. JF - Toxicology AU - Patterson, Tucker A AU - Li, Mi AU - Hotchkiss, Charlotte E AU - Mauz, Annerose AU - Eddie, Malcolm AU - Greischel, Andreas AU - Stierstorfer, Birgit AU - Deschl, Ulrich AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA Y1 - 2010/10/29/ PY - 2010 DA - 2010 Oct 29 SP - 164 EP - 171 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 276 IS - 3 SN - 0300-483X, 0300-483X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Operant conditioning KW - blood pressure KW - Parkinson's disease KW - Heart rate KW - Statistical analysis KW - Histopathology KW - Toxicity KW - Blood pressure KW - Leg KW - Prolactin KW - Neurodegenerative diseases KW - Movement disorders KW - Dopamine KW - heart rate KW - pramipexole KW - Neurotoxicity KW - Macaca mulatta KW - Hematology KW - Neuropathology KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759321279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Toxicity+assessment+of+pramipexole+in+juvenile+rhesus+monkeys&rft.au=Patterson%2C+Tucker+A%3BLi%2C+Mi%3BHotchkiss%2C+Charlotte+E%3BMauz%2C+Annerose%3BEddie%2C+Malcolm%3BGreischel%2C+Andreas%3BStierstorfer%2C+Birgit%3BDeschl%2C+Ulrich%3BPaule%2C+Merle+G&rft.aulast=Patterson&rft.aufirst=Tucker&rft.date=2010-10-29&rft.volume=276&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2010.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 1 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Operant conditioning; Parkinson's disease; Heart rate; Statistical analysis; Blood pressure; Prolactin; Leg; Neurodegenerative diseases; Dopamine; Movement disorders; pramipexole; Neurotoxicity; Neuropathology; heart rate; blood pressure; Histopathology; Hematology; Toxicity; Macaca mulatta DO - http://dx.doi.org/10.1016/j.tox.2010.08.002 ER - TY - JOUR T1 - Declining incidence of imported malaria in the Netherlands, 2000-2007 AN - 853474522; 14025343 AB - To describe the epidemiology and trends of imported malaria in the Netherlands from 2000 through 2007. Based on national surveillance data regarding all reported infections of imported malaria, diagnosed 2000 through 2007, incidence and trends of imported malaria in the Netherlands were estimated. Travellers statistics were used to estimate incidence, and data on malaria chemoprophylaxis prescriptions were used to estimate the number of unprotected travellers. Importation of malaria to the Netherlands is declining even as more travellers visit malaria-endemic countries. On average, 82% were acquired in sub-Saharan Africa, and 75% were caused by Plasmodium falciparum. The overall incidence in imported falciparum malaria fell from 21.5 to 6.6/10,000 of unprotected travellers. The percentage of unprotected travellers rose from 47% to 52% of all travellers. The incidence of imported falciparum infections is greatest from Middle and West Africa, and decreased from 121.3 to 36.5/10,000 travellers. The import of malaria from this region by immigrants visiting friends and relatives (VFR) decreased from 138 infections in 2000, to 69 infections in 2007. The annual number of imported malaria shows a continuing declining trend, even with an increasing number of travellers visiting malaria endemic countries. VFR import less malaria than previously, and contribute largely to the declining incidence seen. The decline is not readily explained by increased use of chemoprophylaxis and may reflect a reduced risk of infection due to decreasing local malaria transmission as observed in some malaria endemic areas. Nevertheless, the increasing number of unprotected travellers remains worrisome. JF - Malaria Journal AU - van Rijckevorsel, Gini GC AU - Sonder, Gerard JB AU - Geskus, Ronald B AU - Wetsteyn, Jose CFM AU - Ligthelm, Robert J AU - Visser, Leo G AU - Keuter, Monique AU - van Genderen, Perry JJ AU - van den Hoek, Anneke AD - Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands Y1 - 2010/10/28/ PY - 2010 DA - 2010 Oct 28 SP - 300 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 9 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Biological surveys KW - Parasites KW - Human diseases KW - Data processing KW - Statistics KW - Travellers KW - Immigrants KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Importation KW - Public health KW - Endemic species KW - Epidemiology KW - Africa KW - Netherlands KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853474522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Declining+incidence+of+imported+malaria+in+the+Netherlands%2C+2000-2007&rft.au=van+Rijckevorsel%2C+Gini+GC%3BSonder%2C+Gerard+JB%3BGeskus%2C+Ronald+B%3BWetsteyn%2C+Jose+CFM%3BLigthelm%2C+Robert+J%3BVisser%2C+Leo+G%3BKeuter%2C+Monique%3Bvan+Genderen%2C+Perry+JJ%3Bvan+den+Hoek%2C+Anneke&rft.aulast=van+Rijckevorsel&rft.aufirst=Gini&rft.date=2010-10-28&rft.volume=9&rft.issue=&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-300 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Biological surveys; Parasites; Endemic species; Human diseases; Epidemiology; Malaria; Public health; Statistics; Data processing; Immigrants; Travellers; Importation; Infection; Plasmodium falciparum; Africa; Netherlands DO - http://dx.doi.org/10.1186/1475-2875-9-300 ER - TY - JOUR T1 - Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial AN - 954609884; 14163750 AB - Background:Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. Methods:Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL)1 beta , 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon- gamma , and tumour necrosis factor- alpha , measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. Results:Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR=1.68, 95% CI=1.13-2.49), whereas decreased IL-1 beta or IL-10 reduced the risk of advanced adenoma recurrence (OR=0.37, 95% CI=0.15-0.94; OR=0.39, 95% CI=0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. Conclusion:Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms. JF - British Journal of Cancer AU - Bobe, G AU - Murphy, G AU - Albert, P S AU - Sansbury, L B AU - Lanza, E AU - Schatzkin, A AU - Colburn, N H AU - Cross, A J AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Building 576, Room 101, 1050 Boyles Street, Frederick, MD 21702, USA Y1 - 2010/10/26/ PY - 2010 DA - 2010 Oct 26 SP - 1453 EP - 1461 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 9 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Risk Abstracts KW - Inventories KW - gamma -Interferon KW - Beverages KW - Interleukin 2 KW - Food KW - Interleukin 1 KW - Granulocyte-macrophage colony-stimulating factor KW - Colorectal cancer KW - Polyps KW - Flavonols KW - Food plants KW - Cancer KW - Interleukin 10 KW - Inflammation KW - Databases KW - intervention KW - Risk factors KW - prevention KW - Cytokines KW - bioactive compounds KW - Tumor necrosis factor- alpha KW - Adenoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954609884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Serum+cytokine+concentrations%2C+flavonol+intake+and+colorectal+adenoma+recurrence+in+the+Polyp+Prevention+Trial&rft.au=Bobe%2C+G%3BMurphy%2C+G%3BAlbert%2C+P+S%3BSansbury%2C+L+B%3BLanza%2C+E%3BSchatzkin%2C+A%3BColburn%2C+N+H%3BCross%2C+A+J&rft.aulast=Bobe&rft.aufirst=G&rft.date=2010-10-26&rft.volume=103&rft.issue=9&rft.spage=1453&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Inventories; Beverages; Interleukin 2; Food; Interleukin 1; Colorectal cancer; Granulocyte-macrophage colony-stimulating factor; Flavonols; Polyps; Food plants; Interleukin 10; Inflammation; Databases; Risk factors; Cytokines; Tumor necrosis factor- alpha; Adenoma; intervention; prevention; bioactive compounds; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605915 ER - TY - JOUR T1 - Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study AN - 876236317; 14087049 AB - Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both MC1R variants and host phenotypes with melanoma risk has been limited. Methods We included 815 CDKN2A mutation carriers (473 affected, and 342 unaffected, with melanoma) from 186 families from 15 centers in Europe, North America, and Australia who participated in the Melanoma Genetics Consortium. In this family-based study, we assessed the associations of the four most frequent MC1R variants (V60L, V92M, R151C, and R160W) and the number of variants (1, greater than or equal to 2 variants), alone or jointly with the host phenotypes (hair color, propensity to sunburn, and number of nevi), with melanoma risk in CDKN2A mutation carriers. These associations were estimated and tested using generalized estimating equations. All statistical tests were two-sided. Results Carrying any one of the four most frequent MC1R variants (V60L, V92M, R151C, R160W) in CDKN2A mutation carriers was associated with a statistically significantly increased risk for melanoma across all continents (1.24 10 super(-6) less than or equal to P less than or equal to .0007). A consistent pattern of increase in melanoma risk was also associated with increase in number of MC1R variants. The risk of melanoma associated with at least two MC1R variants was 2.6-fold higher than the risk associated with only one variant (odds ratio = 5.83 [95% confidence interval = 3.60 to 9.46] vs 2.25 [95% confidence interval = 1.44 to 3.52]; P sub(trend) = 1.86 10 super(-8)). The joint analysis of MC1R variants and host phenotypes showed statistically significant associations of melanoma risk, together with MC1R variants (.0001 less than or equal to P less than or equal to .04), hair color (.006 less than or equal to P less than or equal to .06), and number of nevi (6.9 10 super(-6) less than or equal to P less than or equal to .02). Conclusion Results show that MC1R variants, hair color, and number of nevi were jointly associated with melanoma risk in CDKN2A mutation carriers. This joint association may have important consequences for risk assessments in familial settings. JF - Journal of the National Cancer Institute AU - Demenais, F AU - Mohamdi, H AU - Chaudru, V AU - Goldstein, A M AU - Newton Bishop, JA AU - Bishop, D T AU - Kanetsky, P A AU - Hayward, N K AU - Gillanders, E AU - Elder, DE AU - Avril, M F AU - Azizi, E AU - van Belle, P AU - Bergman, W AU - Bianchi-Scarra, G AU - Bressac-de Paillerets, B AU - Calista, D AU - Carrera, C AU - Hansson, J AU - Harland, M AU - Hogg, D AU - Hoeiom, V AU - Holland, E A AU - Ingvar, C AU - Landi, M T AU - Lang, J M AU - Mackie, R M AU - Mann, G J AU - Ming, ME AU - Njauw, C J AU - Olsson, H AU - Palmer, J AU - Pastorino, L AU - Puig, S AU - Randerson-Moor, J AU - Stark, M AU - Tsao, H AU - Tucker, MA AU - van der Velden, P AU - Yang, X R AU - Gruis, N AD - Affiliations of authors: INSERM, U946, Fondation Jean-Dausset-CEPH, Paris, France (FD, HM, VC, BB-dP); Universite Paris Diderot, Paris 7, Institut Universitaire d'Hematologie, Paris, France (FD, HM); Fondation Jean Dausset-CEPH, Paris, France (FD, HM, VC); Universite d'Evry Val d'Essonne, Evry, France (VC); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AMG, MTL, MAT, XRY); Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital, Leeds, UK (JANB, DTB, MH, JR-M); Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, Philadelphia, PA (PAK); Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queens, florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 1568 EP - 1583 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 20 SN - 0027-8874, 0027-8874 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Pigmentation KW - cyclin-dependent kinase inhibitors KW - Mathematical models KW - Statistical analysis KW - Hair KW - alpha -Melanocyte-stimulating hormone KW - Melanoma KW - Color KW - Risk factors KW - Nevus KW - Mutation KW - X 24340:Cosmetics, Toiletries & Household Products KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876236317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+MC1R+Variants+and+Host+Phenotypes+With+Melanoma+Risk+in+CDKN2A+Mutation+Carriers%3A+A+GenoMEL+Study&rft.au=Demenais%2C+F%3BMohamdi%2C+H%3BChaudru%2C+V%3BGoldstein%2C+A+M%3BNewton+Bishop%2C+JA%3BBishop%2C+D+T%3BKanetsky%2C+P+A%3BHayward%2C+N+K%3BGillanders%2C+E%3BElder%2C+DE%3BAvril%2C+M+F%3BAzizi%2C+E%3Bvan+Belle%2C+P%3BBergman%2C+W%3BBianchi-Scarra%2C+G%3BBressac-de+Paillerets%2C+B%3BCalista%2C+D%3BCarrera%2C+C%3BHansson%2C+J%3BHarland%2C+M%3BHogg%2C+D%3BHoeiom%2C+V%3BHolland%2C+E+A%3BIngvar%2C+C%3BLandi%2C+M+T%3BLang%2C+J+M%3BMackie%2C+R+M%3BMann%2C+G+J%3BMing%2C+ME%3BNjauw%2C+C+J%3BOlsson%2C+H%3BPalmer%2C+J%3BPastorino%2C+L%3BPuig%2C+S%3BRanderson-Moor%2C+J%3BStark%2C+M%3BTsao%2C+H%3BTucker%2C+MA%3Bvan+der+Velden%2C+P%3BYang%2C+X+R%3BGruis%2C+N&rft.aulast=Demenais&rft.aufirst=F&rft.date=2010-10-20&rft.volume=102&rft.issue=20&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq363 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pigmentation; cyclin-dependent kinase inhibitors; Mathematical models; Risk factors; Statistical analysis; Nevus; alpha -Melanocyte-stimulating hormone; Hair; Mutation; Color; Melanoma DO - http://dx.doi.org/10.1093/jnci/djq363 ER - TY - JOUR T1 - Risk Factors for Cervical Precancer and Cancer in HIV-Infected, HPV-Positive Rwandan Women AN - 1014099245; 13966204 AB - Although cervical cancer is an AIDS-defining condition, infection with human immunodeficiency virus (HIV) may only modestly increase the risk of cervical cancer. There is a paucity of information regarding factors that influence the natural history of human papillomavirus (HPV) in HIV-infected women. We examined factors associated with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) in Rwandan women infected with both HIV and HPV (HIV+/HPV+). In 2005, 710 HIV+ Rwandan women .25 years enrolled in an observational cohort study; 476 (67%) tested HPV+. Each woman provided sociodemographic data, CD4 count, a cervical cytology specimen and cervicovaginal lavage (CVL), which was tested for >40 HPV genotypes by MY09/MY11 PCR assay. Logistic regression models calculated odds ratios (OR) and 95% confidence intervals (CI) of associations of potential risk factors for CIN3+ among HIV+/HPV+ women. Of the 476 HIV+/HPV+ women 42 (8.8%) were diagnosed with CIN3+. Factors associated with CIN3+ included .7 (vs. 0-2) pregnancies, malarial infection in the previous six months (vs. never), and .7 (vs. 0-2) lifetime sexual partners. Compared to women infected by non-HPV16 carcinogenic HPV genotypes, HPV16 infection was positively associated and non-carcinogenic HPV infection was inversely associated with CIN3+. CD4 count was significantly associated with CIN3+ only in analyses of women with non-HPV16 carcinogenic HPV (OR=0.62 per 100 cells/mm3, CI=0.40-0.97). In this HIV+/HPV+ population, lower CD4 was significantly associated with CIN3+ only in women infected with carcinogenic non-HPV16. We found a trend for higher risk of CIN3+ in HIV+ women reporting recent malarial infection; this association should be investigated in a larger group of HIV+/HPV+ women. JF - PLoS ONE AU - Anastos, Kathryn AU - Hoover, Donald R AU - Burk, Robert D AU - Cajigas, Antonio AU - Shi, Qiuhu AU - Singh, Diljeet K AU - Cohen, Mardge H AU - Mutimura, Eugene AU - Sturgis, Charles AU - Banzhaf, William C AU - Castle, Philip E AD - National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 0 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts KW - Data processing KW - Nucleotide sequence KW - Cervical cancer KW - Women KW - Genotypes KW - Infection KW - Neoplasia KW - Risks KW - Pregnancy KW - Sexual partners KW - CD4 antigen KW - Human immunodeficiency virus KW - Human papillomavirus 16 KW - Risk factors KW - Regression analysis KW - DNA KW - Polymerase chain reaction KW - Cytology KW - Cervix KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014099245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Risk+Factors+for+Cervical+Precancer+and+Cancer+in+HIV-Infected%2C+HPV-Positive+Rwandan+Women&rft.au=Anastos%2C+Kathryn%3BHoover%2C+Donald+R%3BBurk%2C+Robert+D%3BCajigas%2C+Antonio%3BShi%2C+Qiuhu%3BSingh%2C+Diljeet+K%3BCohen%2C+Mardge+H%3BMutimura%2C+Eugene%3BSturgis%2C+Charles%3BBanzhaf%2C+William+C%3BCastle%2C+Philip+E&rft.aulast=Anastos&rft.aufirst=Kathryn&rft.date=2010-10-20&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013525 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Women; DNA; Cytology; Polymerase chain reaction; Genotypes; Risks; Pregnancy; Sexual partners; CD4 antigen; Data processing; Risk factors; Cervical cancer; Regression analysis; Cervix; Infection; Neoplasia; Human immunodeficiency virus; Human papillomavirus 16; Human papillomavirus DO - http://dx.doi.org/10.1371/journal.pone.0013525 ER - TY - JOUR T1 - Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies AN - 849482081; 14025550 AB - Accumulating evidence indicate that the degree of dispersion of nanoparticles has a strong influence on their biological activities. The aims of this study were to develop a simple and rapid method of nanoparticle dispersion using a natural lung surfactant and to evaluate the effect of dispersion status of SWCNT on cytotoxicity and fibrogenicity in vitro and in vivo. The natural lung surfactant Survanta registered was used to disperse single-walled carbon nanotubes (SWCNT) in a biological medium. At physiologically relevant concentrations, Survanta registered produced well dispersed SWCNT without causing a cytotoxic or fibrogenic effect. In vitro studies show that Survanta registered -dispersed SWCNT (SD-SWCNT) stimulated proliferation of lung epithelial cells at low doses (0.04-0.12 mu g/ml or 0.02-0.06 mu g/cm2 exposed surface area) but had a suppressive effect at high doses. Non-dispersed SWCNT (ND-SWCNT) did not exhibit these effects, suggesting the importance of dispersion status of SWCNT on bioactivities. Studies using cultured human lung fibroblasts show that SD-SWCNT stimulated collagen production of the cells. This result is supported by a similar observation using Acetone/sonication dispersed SWCNT (AD-SWCNT), suggesting that Survanta registered did not mask the bioactivity of SWCNT. Likewise, in vivo studies show that both SD-SWCNT and AD-SWCNT induced lung fibrosis in mice, whereas the dispersing agent Survanta registered alone or Survanta registered -dispersed control ultrafine carbon black had no effect. The results indicate that Survanta registered was effective in dispersing SWCNT in biological media without causing cytotoxic effects at the test concentrations used in this study. SD-SWCNT stimulated collagen production of lung fibroblasts in vitro and induced lung fibrosis in vivo. Similar results were observed with AD-SWCNT, supporting the conclusion that Survanta registered did not mask the bioactivities of SWCNT and thus can be used as an effective dispersing agent. Since excessive collagen production is a hallmark of lung fibrosis, the results of this study suggest that the in vitro model using lung fibroblasts may be an effective and rapid screening tool for prediction of the fibrogenic potential of SWCNT in vivo. JF - Particle and Fibre Toxicology AU - Wang, Liying AU - Castranova, Vincent AU - Mishra, Anurag AU - Chen, Bean AU - Mercer, Robert R AU - Schwegler-Berry, Diane AU - Rojanasakul, Yon AD - National Institute for Occupational Safety and Health, HELD/PPRB, Morgantown, WV 26505, USA Y1 - 2010/10/19/ PY - 2010 DA - 2010 Oct 19 SP - 31 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Epithelial cells KW - Fibrosis KW - Surface area KW - Toxicity KW - Sonication KW - Fibroblasts KW - Collagen KW - Cytotoxicity KW - Carbon KW - Lung KW - nanotubes KW - Acetone KW - Cell proliferation KW - nanoparticles KW - Surfactants KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849482081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Dispersion+of+single-walled+carbon+nanotubes+by+a+natural+lung+surfactant+for+pulmonary+in+vitro+and+in+vivo+toxicity+studies&rft.au=Wang%2C+Liying%3BCastranova%2C+Vincent%3BMishra%2C+Anurag%3BChen%2C+Bean%3BMercer%2C+Robert+R%3BSchwegler-Berry%2C+Diane%3BRojanasakul%2C+Yon&rft.aulast=Wang&rft.aufirst=Liying&rft.date=2010-10-19&rft.volume=7&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Fibrosis; Surface area; Toxicity; Collagen; Fibroblasts; Sonication; Cytotoxicity; Carbon; Lung; nanotubes; Acetone; Cell proliferation; Surfactants; nanoparticles DO - http://dx.doi.org/10.1186/1743-8977-7-31 ER - TY - JOUR T1 - Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary. AN - 758836611; 20739433 AB - On September 24, 2009, the U.S. Food and Drug Administration granted accelerated approval for Folotyn (pralatrexate injection, Allos Therapeutics, Inc.) as a single agent for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL); it is the first drug approved for this indication. This review was based on study PDX-008, a phase II, single-arm, nonrandomized, open-label, international, multicenter trial, designed to evaluate the safety and efficacy of pralatrexate when administered concurrently with vitamin B(12) and folic acid supplementation in patients with relapsed or refractory PTCL. The overall response rate was 27% in 109 evaluable patients [95% confidence interval (CI), 19-36%]. Twelve percent of 109 evaluable patients (95% CI, 7-20%)] had a response duration of ≥14 weeks. Six of these 13 patients achieved a complete response, and one patient had complete response unconfirmed. The most common grade 3 and 4 toxicities were thrombocytopenia, mucositis, and neutropenia. This accelerated approval was based on a response rate that is reasonably likely to predict clinical benefit in this heavily pretreated patient population with this rare disease. The applicant has committed to conducting postmarketing clinical trials to assess clinical benefit. The recommended starting dose of pralatrexate in patients with relapsed or refractory PTCL is 30 mg/m(2) via intravenous push over 3 to 5 min weekly for 6 weeks followed by a one-week rest (one cycle). Intramuscular injection of 1 mg vitamin B(12) should be administered every 8 to 10 weeks along with 1.0 mg folic acid given orally once a day. ©2010 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Malik, Shakun M AU - Liu, Ke AU - Qiang, Xu AU - Sridhara, Rajeshwari AU - Tang, Shenghui AU - McGuinn, W David AU - Verbois, S Leigh AU - Marathe, Anshu AU - Williams, Gene M AU - Bullock, Julie AU - Tornoe, Christoffer AU - Lin, Sue Ching AU - Ocheltree, Terrance AU - Vialpando, Milinda AU - Kacuba, Alice AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. shakun.malik@fda.hhs Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 4921 EP - 4927 VL - 16 IS - 20 SN - 1078-0432, 1078-0432 KW - 10-propargyl-10-deazaaminopterin KW - 0 KW - Folic Acid Antagonists KW - Aminopterin KW - JYB41CTM2Q KW - Index Medicus KW - United States KW - Folic Acid Antagonists -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Folic Acid Antagonists -- adverse effects KW - Aged KW - Middle Aged KW - Folic Acid Antagonists -- chemistry KW - Male KW - Female KW - Aminopterin -- adverse effects KW - Lymphoma, T-Cell -- drug therapy KW - Aminopterin -- chemistry KW - Aminopterin -- therapeutic use KW - Aminopterin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758836611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Quantification+of+deuterated+bisphenol+A+in+serum%2C+tissues%2C+and+excreta+from+adult+Sprague-Dawley+rats+using+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Twaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Twaddle&rft.aufirst=Nathan&rft.date=2010-10-30&rft.volume=24&rft.issue=20&rft.spage=3011&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=1097-0231&rft_id=info:doi/10.1002%2Frcm.4733 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-14 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-10-1214 ER - TY - JOUR T1 - Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients. AN - 756660543; 20579973 AB - Cocaine users not seeking treatment have increased regional brain mu-opioid receptor (mOR) binding that correlates with cocaine craving and tendency to relapse. In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown. We determined whether regional brain mOR binding before treatment correlates with outcome and compared it with standard clinical predictors of outcome. Twenty-five individuals seeking outpatient treatment for cocaine abuse or dependence (DSM-IV) received up to 12 weeks of cognitive-behavioral therapy and cocaine abstinence reinforcement, whereby each cocaine-free urine was reinforced with vouchers redeemable for goods. Regional brain mOR binding was measured before treatment using positron emission tomography with [¹¹C]]-carfentanil (a selective mOR agonist). Main outcome measures were: 1) overall percentage of urines positive for cocaine during first month of treatment; and 2) longest duration (weeks) of abstinence from cocaine during treatment, all verified by urine toxicology. Elevated mOR binding in the medial frontal and middle frontal gyri before treatment correlated with greater cocaine use during treatment. Elevated mOR binding in the anterior cingulate, medial frontal, middle frontal, middle temporal, and sublobar insular gyri correlated with shorter duration of cocaine abstinence during treatment. Regional mOR binding contributed significant predictive power for treatment outcome beyond that of standard clinical variables such as baseline drug and alcohol use. Elevated mOR binding in brain regions associated with reward sensitivity is a significant independent predictor of treatment outcome in cocaine-abusing outpatients, suggesting a key role for the brain endogenous opioid system in cocaine addiction. Published by Elsevier Inc. JF - Biological psychiatry AU - Ghitza, Udi E AU - Preston, Kenzie L AU - Epstein, David H AU - Kuwabara, Hiroto AU - Endres, Christopher J AU - Bencherif, Badreddine AU - Boyd, Susan J AU - Copersino, Marc L AU - Frost, J James AU - Gorelick, David A AD - Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. ghitzau@nida.nih.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 697 EP - 703 VL - 68 IS - 8 KW - Receptors, Opioid, mu KW - 0 KW - Cocaine KW - I5Y540LHVR KW - carfentanil KW - LA9DTA2L8F KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Magnetic Resonance Imaging KW - Positron-Emission Tomography -- methods KW - Cocaine -- urine KW - Humans KW - Adult KW - Treatment Outcome KW - Fentanyl -- metabolism KW - Predictive Value of Tests KW - Radioligand Assay -- methods KW - Fentanyl -- analogs & derivatives KW - Male KW - Female KW - Cocaine-Related Disorders -- therapy KW - Brain -- metabolism KW - Receptors, Opioid, mu -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging KW - Cognitive Therapy -- methods KW - Cocaine-Related Disorders -- urine KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756660543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Brain+mu-opioid+receptor+binding+predicts+treatment+outcome+in+cocaine-abusing+outpatients.&rft.au=Ghitza%2C+Udi+E%3BPreston%2C+Kenzie+L%3BEpstein%2C+David+H%3BKuwabara%2C+Hiroto%3BEndres%2C+Christopher+J%3BBencherif%2C+Badreddine%3BBoyd%2C+Susan+J%3BCopersino%2C+Marc+L%3BFrost%2C+J+James%3BGorelick%2C+David+A&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2010-10-15&rft.volume=68&rft.issue=8&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2010.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-09 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2009 Jul;34(8):1946-57 [19279569] Trends Neurosci. 2009 Jan;32(1):56-67 [18986715] Psychopharmacology (Berl). 2008 Nov;200(4):475-86 [18762918] Neurosci Biobehav Rev. 2010 Nov;35(2):220-31 [20170672] Am J Psychiatry. 2000 Jan;157(1):127-9 [10618027] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Ann N Y Acad Sci. 2001 Jun;937:74-92 [11458541] J Neurosci. 2002 Jun 15;22(12):5100-7 [12077205] Drug Alcohol Depend. 2002 Sep 1;68(1):35-48 [12167551] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Nucl Med Biol. 2003 Feb;30(2):177-86 [12623117] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Clin Pharmacol Ther. 2004 Jan;75(1):34-48 [14749690] Biol Psychiatry. 2004 Apr 1;55(7):759-65 [15039006] J Consult Clin Psychol. 1984 Oct;52(5):774-83 [6501663] J Comput Assist Tomogr. 1985 Mar-Apr;9(2):231-6 [2982931] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Pers Soc Psychol. 1986 Mar;50(3):571-9 [3701593] J Consult Clin Psychol. 1988 Oct;56(5):715-20 [3192787] J Comput Assist Tomogr. 1995 Sep-Oct;19(5):788-96 [7560327] Brain Res. 1995 Jun 5;682(1-2):245-50 [7552322] J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40 [8784228] Nat Med. 1996 Nov;2(11):1225-9 [8898749] IEEE Trans Med Imaging. 1997 Apr;16(2):187-98 [9101328] Am J Psychiatry. 1999 Jun;156(6):842-8 [10360121] Eur Neuropsychopharmacol. 2005 May;15(3):297-303 [15820419] J Neurosci. 2005 May 4;25(18):4512-20 [15872098] Biol Psychiatry. 2005 Jun 15;57(12):1573-82 [15953495] Arch Gen Psychiatry. 2005 Jul;62(7):761-8 [15997017] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Am J Addict. 2006 Nov-Dec;15(6):434-9 [17182445] Science. 2007 Jan 26;315(5811):531-4 [17255515] Am J Drug Alcohol Abuse. 2007;33(2):191-206 [17497542] Biol Psychiatry. 2007 Jun 1;61(11):1252-9 [16945342] Cochrane Database Syst Rev. 2007;(3):CD003023 [17636713] Am J Psychiatry. 2008 Nov;165(11):1442-8 [18765480] Comment In: Biol Psychiatry. 2010 Oct 15;68(8):685-6 [20888455] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2010.05.003 ER - TY - JOUR T1 - Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. AN - 749010896; 20099276 AB - Cancer cells that develop resistance to chemotherapeutic agents are a major clinical obstacle in the successful treatment of breast cancer. Acquired cancer chemoresistance is a multifactorial phenomenon, involving various mechanisms and processes. Recent studies suggest that chemoresistance may be linked to drug-induced dysregulation of microRNA function. Furthermore, mounting evidence indicates the existence of similarities between drug-resistant and metastatic cancer cells in terms of resistance to apoptosis and enhanced invasiveness. We studied the role of miRNA alterations in the acquisition of cisplatin-resistant phenotype in MCF-7 human breast adenocarcinoma cells. We identified a total of 103 miRNAs that were overexpressed or underexpressed (46 upregulated and 57 downregulated) in MCF-7 cells resistant to cisplatin. These differentially expressed miRNAs are involved in the control of cell signaling, cell survival, DNA methylation and invasiveness. The most significantly dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c. Furthermore, we demonstrated that miR-345 and miR-7 target the human multidrug resistance-associated protein 1. These results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin-resistant phenotype. JF - International journal of cancer AU - Pogribny, Igor P AU - Filkowski, Jody N AU - Tryndyak, Volodymyr P AU - Golubov, Andrey AU - Shpyleva, Svitlana I AU - Kovalchuk, Olga AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 1785 EP - 1794 VL - 127 IS - 8 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - MicroRNAs KW - Multidrug Resistance-Associated Proteins KW - RNA, Messenger KW - Luciferases KW - EC 1.13.12.- KW - Cisplatin KW - Q20Q21Q62J KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Luciferases -- metabolism KW - RNA, Messenger -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Multidrug Resistance-Associated Proteins -- genetics KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Female KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Cisplatin -- pharmacology KW - Drug Resistance, Neoplasm KW - MicroRNAs -- physiology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749010896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Alterations+of+microRNAs+and+their+targets+are+associated+with+acquired+resistance+of+MCF-7+breast+cancer+cells+to+cisplatin.&rft.au=Pogribny%2C+Igor+P%3BFilkowski%2C+Jody+N%3BTryndyak%2C+Volodymyr+P%3BGolubov%2C+Andrey%3BShpyleva%2C+Svitlana+I%3BKovalchuk%2C+Olga&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-15&rft.volume=127&rft.issue=8&rft.spage=1785&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25191 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-23 N1 - Date created - 2010-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25191 ER - TY - JOUR T1 - Evaluating the use of fatty acid profiles to identify deep-sea Vibrio isolates AN - 745936282; 13139866 AB - Capillary gas chromatography with flame ionisation detection (GC-FID) was used to determine the cellular fatty acid (CFA) profiles of a number of Vibrio strains obtained from ATCC and grown on various media. This initial determination for optimal growth conditions, including type of medium and incubation temperature, for these various ATCC Vibrio species, was important for use in the subsequent evaluation of deep-sea Vibrio strains. The deep-sea Vibrios were obtained from Harbor Branch Oceanographic Institution (Fort Pierce, FL), and GC-FID analysis was used to determine whole cell fatty acid methyl esters (FAMEs) from the cells. The Vibrio strains were cultured for 24 h on a specific medium which included brain heart infusion (BHI) agar, trypticase soy agar (TSA), trypticase soy broth agar (TSBA), and Luria-Bertani (LB) agar. The temperature of incubation was 28 C for cells grown on TSA, TSBA, and LB and 35 C for BHI. A data set for each Vibrio species was prepared, using fatty acid profiles for a specific medium. Major fatty acids of the Vibrio strains evaluated in this study were straight-chain C sub(12:0), C sub(14:0), C sub(16:0), and unsaturated summed C sub(16:1) Omega 7c/C sub(16:1) Omega 6c, C sub(18:1) Omega 7c, and summed C sub(14:0) 3-OH/iso-C sub(16:1). Most of the deep-sea Vibrio isolates were identified as Vibrio parahaemolyticus and Vibrio harveyi. Analysis of FAMEs from Vibro strains grown on a specific medium by this rapid GC-FID method can provide a sensitive procedure for the identification of these organisms, and the differentiation between Vibrio species. JF - Food Chemistry AU - Hoffmann, Maria AU - Fischer, Markus AU - Whittaker, Paul AD - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, United States, paul.whittaker@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 943 EP - 950 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 122 IS - 4 SN - 0308-8146, 0308-8146 KW - ASFA Marine Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Agar KW - ASW, USA, Florida, Fort Pierce KW - Growth conditions KW - Chromatographic techniques KW - Vibrio harveyi KW - Differentiation KW - Gas chromatography KW - Vibrio parahaemolyticus KW - fatty acid methyl esters KW - Disease detection KW - Circulatory system KW - Temperature effects KW - Heart KW - Data processing KW - Brain KW - Strains KW - Harbours KW - Soybeans KW - Vibrio KW - Fatty acids KW - Q1 08626:Food technology KW - Q4 27760:Microorganisms KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745936282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Evaluating+the+use+of+fatty+acid+profiles+to+identify+deep-sea+Vibrio+isolates&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BWhittaker%2C+Paul&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-10-15&rft.volume=122&rft.issue=4&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2010.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Heart; Agar; Chromatographic techniques; Brain; Fatty acids; Disease detection; Strains; Harbours; Circulatory system; Temperature effects; Differentiation; Data processing; Gas chromatography; Growth conditions; fatty acid methyl esters; Soybeans; Vibrio; Vibrio parahaemolyticus; Vibrio harveyi; ASW, USA, Florida, Fort Pierce DO - http://dx.doi.org/10.1016/j.foodchem.2010.04.015 ER - TY - JOUR T1 - Covariate adjusted weighted normal spatial scan statistics with applications to study geographic clustering of obesity and lung cancer mortality in the United States AN - 1017971515; 16691203 AB - In the field of cluster detection, a weighted normal model-based scan statistic was recently developed to analyze regional continuous data and to evaluate the clustering pattern of pre-defined cells (such as state, county, tract, school, hospital) that include many individuals. The continuous measures of interest are, for example, the survival rate, mortality rate, length of physical activity, or the obesity measure, namely, body mass index, at the cell level with an uncertainty measure for each cell. In this paper, we extend the method to search for clusters of the cells after adjusting for single/multiple categorical/continuous covariates. We apply the proposed method to 1999-2003 obesity data in the United States (US) collected by CDC's Behavioral Risk Factor Surveillance System with adjustment for age and race, and to 1999-2003 lung cancer age-adjusted mortality data by gender in the United States from the Surveillance Epidemiology and End Results (SEER Program) with adjustment for smoking and income. JF - Statistics in Medicine AU - Huang, Lan AU - Tiwari, Ram C AU - Pickle, Linda W AU - Zou, Zhaohui AD - Office of Biostatistics, CDER, FDA, Silver Spring, MD 20993, U.S.A., lan.huang@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 2410 EP - 2422 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 23 SN - 1097-0258, 1097-0258 KW - Risk Abstracts KW - Cancer KW - Hospitals KW - Lung cancer KW - Mortality KW - Risk factors KW - income KW - obesity KW - schools KW - survival KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017971515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=Covariate+adjusted+weighted+normal+spatial+scan+statistics+with+applications+to+study+geographic+clustering+of+obesity+and+lung+cancer+mortality+in+the+United+States&rft.au=Huang%2C+Lan%3BTiwari%2C+Ram+C%3BPickle%2C+Linda+W%3BZou%2C+Zhaohui&rft.aulast=Huang&rft.aufirst=Lan&rft.date=2010-10-15&rft.volume=29&rft.issue=23&rft.spage=2410&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.3990 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.3990/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Mortality; schools; income; Risk factors; obesity; survival; Cancer; Hospitals; Lung cancer; USA DO - http://dx.doi.org/10.1002/sim.3990 ER - TY - JOUR T1 - Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay AN - 849476646; 14024108 AB - For more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe a rapid and simple gold nanoparticle (NP)-based genomic microarray assay for specific identification of avian influenza virus H5N1 and its discrimination from other major influenza A virus strains (H1N1, H3N2). Capture and intermediate oligonucleotides were designed based on the consensus sequences of the matrix (M) gene of H1N1, H3N2 and H5N1 viruses, and sequences specific for the hemaglutinin (HA) and neuraminidase (NA) genes of the H5N1 virus. Viral RNA was detected within 2.5 hours using capture-target-intermediate oligonucleotide hybridization and gold NP-mediated silver staining in the absence of RNA fragmentation, target amplification, and enzymatic reactions. The lower limit of detection (LOD) of the assay was less than 100 fM for purified PCR fragments and 103 TCID50 units for H5N1 viral RNA. The NP-based microarray assay was able to detect and distinguish H5N1 sequences from those of major influenza A viruses (H1N1, H3N2). The new method described here may be useful for simultaneous detection and subtyping of major influenza A viruses. JF - BMC Biotechnology AU - Zhao, Jiangqin AU - Tang, Shixing AU - Storhoff, James AU - Marla, Sudhakar AU - Bao, Y Paul AU - Wang, Xue AU - Wong, Eric Y AU - Ragupathy, Viswanath AU - Ye, Zhiping AU - Hewlett, Indira K AD - Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 SP - 74 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Avian influenza virus KW - Influenza A KW - RNA viruses KW - double prime M gene KW - Oligonucleotides KW - Fowl plague KW - RNA KW - Influenza A virus KW - Gold KW - Polymerase chain reaction KW - genomics KW - Exo- alpha -sialidase KW - nanoparticles KW - nanotechnology KW - G 07880:Human Genetics KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849476646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biotechnology&rft.atitle=Multiplexed%2C+rapid+detection+of+H5N1+using+a+PCR-free+nanoparticle-based+genomic+microarray+assay&rft.au=Zhao%2C+Jiangqin%3BTang%2C+Shixing%3BStorhoff%2C+James%3BMarla%2C+Sudhakar%3BBao%2C+Y+Paul%3BWang%2C+Xue%3BWong%2C+Eric+Y%3BRagupathy%2C+Viswanath%3BYe%2C+Zhiping%3BHewlett%2C+Indira+K&rft.aulast=Zhao&rft.aufirst=Jiangqin&rft.date=2010-10-13&rft.volume=10&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=BMC+Biotechnology&rft.issn=1472-6750&rft_id=info:doi/10.1186%2F1472-6750-10-74 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Fowl plague; RNA; Influenza A; Polymerase chain reaction; Gold; RNA viruses; Exo- alpha -sialidase; genomics; double prime M gene; nanoparticles; Oligonucleotides; nanotechnology; Avian influenza virus; Influenza A virus DO - http://dx.doi.org/10.1186/1472-6750-10-74 ER - TY - JOUR T1 - An acute dose of gamma-hydroxybutyric acid alters gene expression in multiple mouse brain regions. AN - 754013625; 20654702 AB - Gamma-hydroxybutyric acid (GHB) is normally found in the brain in low concentrations and may function as a neurotransmitter, although the mechanism of action has not been completely elucidated. GHB has been used as a general anesthetic and is currently used to treat narcolepsy and alcoholism. Recreational use of GHB is primarily as a "club drug" and a "date rape drug," due to its amnesic effects. For this study, the hypothesis was that behavioral and neurochemical alterations may parallel gene expression changes in the brain after GHB administration. Adult male C57/B6N mice (n=5/group) were administered a single dose of 500 mg/kg GHB (i.p.) and were sacrificed 1, 2 and 4 h after treatment. Control mice were administered saline. Brains were removed and regionally dissected on ice. Total RNA from the hippocampus, cortex and striatum was extracted, amplified and labeled. Gene expression was evaluated using Agilent whole mouse genome 4x44K oligonucleotide microarrays. Microarray data were analyzed by ArrayTrack and differentially expressed genes (DEGs) were identified using P or = 1.7 as the criteria for significance. Principal component analysis (PCA) and Hierarchical Cluster Analysis (HCA) showed that samples from each time point clustered into distinct treatment groups with respect to sacrifice time. Ingenuity pathways analysis (IPA) was used to identify involved pathways. The results show that GHB induces gene expression alterations in hundreds of genes in the hippocampus, cortex and striatum, and the number of affected genes increases throughout a 4-h time course. Many of these DEGs are involved in neurological disease, apoptosis, and oxidative stress. Published by Elsevier Ltd. JF - Neuroscience AU - Schnackenberg, B J AU - Saini, U T AU - Robinson, B L AU - Ali, S F AU - Patterson, T A AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Bradley.Schnackenberg@fda.hhs.gov Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 SP - 523 EP - 541 VL - 170 IS - 2 KW - Hydroxybutyrates KW - 0 KW - 4-hydroxybutyric acid KW - 30IW36W5B2 KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Sleep -- drug effects KW - Mice, Inbred C57BL KW - Dopamine -- metabolism KW - Mice KW - Serotonin -- metabolism KW - Time Factors KW - Male KW - Gene Expression -- drug effects KW - Brain -- drug effects KW - Hydroxybutyrates -- pharmacology KW - Microarray Analysis -- methods KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754013625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Multiple+Antigen+Peptide+Vaccines+against+Plasmodium+falciparum+Malaria&rft.au=Mahajan%2C+Babita%3BBerzofsky%2C+Jay+A%3BBoykins%2C+Robert+A%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BChattopadhyay%2C+Rana%3Bla+Vega%2C+Patricia+de%3BMoch%2C+JKathleen%3BHaynes%2C+JDavid%3BBelyakov%2C+Igor+M&rft.aulast=Mahajan&rft.aufirst=Babita&rft.date=2010-11-01&rft.volume=78&rft.issue=11&rft.spage=4613&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00533-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2010.06.049 ER - TY - JOUR T1 - Two new ArrayTrack libraries for personalized biomedical research AN - 954603048; 14323801 AB - Recent advances in high-throughput genotyping technology are paving the way for research in personalized medicine and nutrition. However, most of the genetic markers identified from association studies account for a small contribution to the total risk/benefit of the studied phenotypic trait. Testing whether the candidate genes identified by association studies are causal is critically important to the development of personalized medicine and nutrition. An efficient data mining strategy and a set of sophisticated tools are necessary to help better understand and utilize the findings from genetic association studies. SNP (single nucleotide polymorphism) and QTL (quantitative trait locus) libraries were constructed and incorporated into ArrayTrack, with user-friendly interfaces and powerful search features. Data from several public repositories were collected in the SNP and QTL libraries and connected to other domain libraries (genes, proteins, metabolites, and pathways) in ArrayTrack. Linking the data sets within ArrayTrack allows searching of SNP and QTL data as well as their relationships to other biological molecules. The SNP library includes approximately 15 million human SNPs and their annotations, while the QTL library contains publically available QTLs identified in mouse, rat, and human. The QTL library was developed for finding the overlap between the map position of a candidate or metabolic gene and QTLs from these species. Two use cases were included to demonstrate the utility of these tools. The SNP and QTL libraries are freely available to the public through ArrayTrack at http://www.fda.gov/ArrayTrack. These libraries developed in ArrayTrack contain comprehensive information on SNPs and QTLs and are further cross-linked to other libraries. Connecting domain specific knowledge is a cornerstone of systems biology strategies and allows for a better understanding of the genetic and biological context of the findings from genetic association studies. JF - BMC Bioinformatics AU - Xu, Joshua AU - Wise, Carolyn AU - Varma, Vijayalakshmi AU - Fang, Hong AU - Ning, Baitang AU - Hong, Huixiao AU - Tong, Weida AU - Kaput, Jim AD - Z-Tech Corporation, an ICF International company at NCTR, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S6 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Biotechnology and Bioengineering Abstracts KW - Quantitative trait loci KW - Data processing KW - Single-nucleotide polymorphism KW - Genotyping KW - Genetic markers KW - Metabolites KW - Bioinformatics KW - Nutrition KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Two+new+ArrayTrack+libraries+for+personalized+biomedical+research&rft.au=Xu%2C+Joshua%3BWise%2C+Carolyn%3BVarma%2C+Vijayalakshmi%3BFang%2C+Hong%3BNing%2C+Baitang%3BHong%2C+Huixiao%3BTong%2C+Weida%3BKaput%2C+Jim&rft.aulast=Xu&rft.aufirst=Joshua&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S6&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Quantitative trait loci; Data processing; Single-nucleotide polymorphism; Genotyping; Genetic markers; Metabolites; Bioinformatics; Nutrition DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S6 ER - TY - JOUR T1 - The EDKB: an established knowledge base for endocrine disrupting chemicals AN - 954603044; 14323800 AB - Endocrine disruptors (EDs) and their broad range of potential adverse effects in humans and other animals have been a concern for nearly two decades. Many putative EDs are widely used in commercial products regulated by the Food and Drug Administration (FDA) such as food packaging materials, ingredients of cosmetics, medical and dental devices, and drugs. The Endocrine Disruptor Knowledge Base (EDKB) project was initiated in the mid 1990's by the FDA as a resource for the study of EDs. The EDKB database, a component of the project, contains data across multiple assay types for chemicals across a broad structural diversity. This paper demonstrates the utility of EDKB database, an integral part of the EDKB project, for understanding and prioritizing EDs for testing. The EDKB database currently contains 3,257 records of over 1,800 EDs from different assays including estrogen receptor binding, androgen receptor binding, uterotropic activity, cell proliferation, and reporter gene assays. Information for each compound such as chemical structure, assay type, potency, etc. is organized to enable efficient searching. A user-friendly interface provides rapid navigation, Boolean searches on EDs, and both spreadsheet and graphical displays for viewing results. The search engine implemented in the EDKB database enables searching by one or more of the following fields: chemical structure (including exact search and similarity search), name, molecular formula, CAS registration number, experiment source, molecular weight, etc. The data can be cross-linked to other publicly available and related databases including TOXNET, Cactus, ChemIDplus, ChemACX, Chem Finder, and NCI DTP. The EDKB database enables scientists and regulatory reviewers to quickly access ED data from multiple assays for specific or similar compounds. The data have been used to categorize chemicals according to potential risks for endocrine activity, thus providing a basis for prioritizing chemicals for more definitive but expensive testing. The EDKB database is publicly available and can be found online at http://edkb.fda.gov/webstart/edkb/index.html. Disclaimer:The views presented in this article do not necessarily reflect those of the US Food and Drug Administration. JF - BMC Bioinformatics AU - Ding, Don AU - Xu, Lei AU - Fang, Hong AU - Hong, Huixiao AU - Perkins, Roger AU - Harris, Steve AU - Bearden, Edward D AU - Shi, Leming AU - Tong, Weida AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S5 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Endocrine disruptors KW - Computer graphics KW - Cosmetics KW - Packaging materials KW - Androgen receptors KW - Databases KW - Reporter gene KW - Molecular weight KW - Bioinformatics KW - Cell proliferation KW - Estrogen receptors KW - Internet KW - Side effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=The+EDKB%3A+an+established+knowledge+base+for+endocrine+disrupting+chemicals&rft.au=Ding%2C+Don%3BXu%2C+Lei%3BFang%2C+Hong%3BHong%2C+Huixiao%3BPerkins%2C+Roger%3BHarris%2C+Steve%3BBearden%2C+Edward+D%3BShi%2C+Leming%3BTong%2C+Weida&rft.aulast=Ding&rft.aufirst=Don&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S5&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Endocrine disruptors; Computer graphics; Cosmetics; Packaging materials; Androgen receptors; Databases; Reporter gene; Molecular weight; Bioinformatics; Cell proliferation; Estrogen receptors; Side effects; Internet DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S5 ER - TY - JOUR T1 - An FDA bioinformatics tool for microbial genomics research on molecular characterization of bacterial foodborne pathogens using microarrays AN - 918045735; 14323799 AB - Advances in microbial genomics and bioinformatics are offering greater insights into the emergence and spread of foodborne pathogens in outbreak scenarios. The Food and Drug Administration (FDA) has developed a genomics tool, ArrayTrackTM, which provides extensive functionalities to manage, analyze, and interpret genomic data for mammalian species. ArrayTrackTM has been widely adopted by the research community and used for pharmacogenomics data review in the FDA's Voluntary Genomics Data Submission program. ArrayTrackTM has been extended to manage and analyze genomics data from bacterial pathogens of human, animal, and food origin. It was populated with bioinformatics data from public databases such as NCBI, Swiss-Prot, KEGG Pathway, and Gene Ontology to facilitate pathogen detection and characterization. ArrayTrackTM's data processing and visualization tools were enhanced with analysis capabilities designed specifically for microbial genomics including flag-based hierarchical clustering analysis (HCA), flag concordance heat maps, and mixed scatter plots. These specific functionalities were evaluated on data generated from a custom Affymetrix array (FDA-ECSG) previously developed within the FDA. The FDA-ECSG array represents 32 complete genomes of Escherichia coli and Shigella. The new functions were also used to analyze microarray data focusing on antimicrobial resistance genes from Salmonella isolates in a poultry production environment using a universal antimicrobial resistance microarray developed by the United States Department of Agriculture (USDA). The application of ArrayTrackTM to different microarray platforms demonstrates its utility in microbial genomics research, and thus will improve the capabilities of the FDA to rapidly identify foodborne bacteria and their genetic traits (e.g., antimicrobial resistance, virulence, etc.) during outbreak investigations. ArrayTrackTM is free to use and available to public, private, and academic researchers at http://www.fda.gov/ArrayTrack. JF - BMC Bioinformatics AU - Fang, Hong AU - Xu, Joshua AU - Ding, Don AU - Jackson, Scott A AU - Patel, Isha R AU - Frye, Jonathan G AU - Zou, Wen AU - Nayak, Rajesh AU - Foley, Steven AU - Chen, James AU - Su, Zhenqiang AU - Ye, Yanbin AU - Turner, Steve AU - Harris, Steve AU - Zhou, Guangxu AU - Cerniglia, Carl AU - Tong, Weida AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S4 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Agriculture KW - Genomes KW - Poultry KW - Drug resistance KW - Anadromous species KW - DNA microarrays KW - Disease transmission KW - Virulence KW - Computer programs KW - Escherichia coli KW - genomics KW - Drugs KW - Data processing KW - pharmacogenomics KW - Shigella KW - Pathogens KW - Databases KW - USA KW - Heat KW - Reviews KW - Bioinformatics KW - Salmonella KW - Gene mapping KW - J 02310:Genetics & Taxonomy KW - Q1 08484:Species interactions: parasites and diseases KW - A 01330:Food Microbiology KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918045735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=An+FDA+bioinformatics+tool+for+microbial+genomics+research+on+molecular+characterization+of+bacterial+foodborne+pathogens+using+microarrays&rft.au=Fang%2C+Hong%3BXu%2C+Joshua%3BDing%2C+Don%3BJackson%2C+Scott+A%3BPatel%2C+Isha+R%3BFrye%2C+Jonathan+G%3BZou%2C+Wen%3BNayak%2C+Rajesh%3BFoley%2C+Steven%3BChen%2C+James%3BSu%2C+Zhenqiang%3BYe%2C+Yanbin%3BTurner%2C+Steve%3BHarris%2C+Steve%3BZhou%2C+Guangxu%3BCerniglia%2C+Carl%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Data processing; Anadromous species; Pathogens; Drugs; Disease transmission; Agriculture; Poultry; pharmacogenomics; Drug resistance; DNA microarrays; Computer programs; Databases; Heat; Reviews; genomics; Bioinformatics; Gene mapping; Escherichia coli; Shigella; Salmonella; USA DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S4 ER - TY - JOUR T1 - Evaluation of gene expression data generated from expired Affymetrix GeneChip registered microarrays using MAQC reference RNA samples AN - 874180396; 14323777 AB - The Affymetrix GeneChip registered system is a commonly used platform for microarray analysis but the technology is inherently expensive. Unfortunately, changes in experimental planning and execution, such as the unavailability of previously anticipated samples or a shift in research focus, may render significant numbers of pre-purchased GeneChip registered microarrays unprocessed before their manufacturer's expiration dates. Researchers and microarray core facilities wonder whether expired microarrays are still useful for gene expression analysis. In addition, it was not clear whether the two human reference RNA samples established by the MAQC project in 2005 still maintained their transcriptome integrity over a period of four years. Experiments were conducted to answer these questions. Microarray data were generated in 2009 in three replicates for each of the two MAQC samples with either expired Affymetrix U133A or unexpired U133Plus2 microarrays. These results were compared with data obtained in 2005 on the U133Plus2 microarray. The percentage of overlap between the lists of differentially expressed genes (DEGs) from U133Plus2 microarray data generated in 2009 and in 2005 was 97.44%. While there was some degree of fold change compression in the expired U133A microarrays, the percentage of overlap between the lists of DEGs from the expired and unexpired microarrays was as high as 96.99%. Moreover, the microarray data generated using the expired U133A microarrays in 2009 were highly concordant with microarray and TaqMan registered data generated by the MAQC project in 2005. Our results demonstrated that microarray data generated using U133A microarrays, which were more than four years past the manufacturer's expiration date, were highly specific and consistent with those from unexpired microarrays in identifying DEGs despite some appreciable fold change compression and decrease in sensitivity. Our data also suggested that the MAQC reference RNA samples, stored at -80 degree C, were stable over a time frame of at least four years. JF - BMC Bioinformatics AU - Wen, Zhining AU - Wang, Charles AU - Shi, Quan AU - Huang, Ying AU - Su, Zhenqiang AU - Hong, Huixiao AU - Tong, Weida AU - Shi, Leming AD - Division of Systems Biology, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S10 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Bioinformatics KW - DNA microarrays KW - Compression KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874180396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Evaluation+of+gene+expression+data+generated+from+expired+Affymetrix+GeneChip+registered+microarrays+using+MAQC+reference+RNA+samples&rft.au=Wen%2C+Zhining%3BWang%2C+Charles%3BShi%2C+Quan%3BHuang%2C+Ying%3BSu%2C+Zhenqiang%3BHong%2C+Huixiao%3BTong%2C+Weida%3BShi%2C+Leming&rft.aulast=Wen&rft.aufirst=Zhining&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; RNA; Bioinformatics; DNA microarrays; Compression DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S10 ER - TY - JOUR T1 - Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the Netherlands AN - 839684143; 13969148 AB - Implementing Chlamydia trachomatis screening in the Netherlands has been a point of debate for several years. The National Health Council advised against implementing nationwide screening until additional data collected from a pilot project in 2003 suggested that screening by risk profiles could be effective. A continuous increase in infections recorded in the national surveillance database affirmed the need for a more active approach. Here, we describe the rationale, design, and implementation of a Chlamydia screening demonstration programme. A systematic, selective, internet-based Chlamydia screening programme started in April 2008. Letters are sent annually to all 16 to 29-year-old residents of Amsterdam, Rotterdam, and selected municipalities of South Limburg. The letters invite sexually active persons to login to http://www.chlamydiatest.nl with a personal code and to request a test kit. In the lower prevalence area of South Limburg, test kits can only be requested if the internet-based risk assessment exceeds a predefined value. We sent invitations to 261,025 people in the first round. One-fifth of the invitees requested a test kit, of whom 80% sent in a sample for testing. The overall positivity rate was 4.2%. This programme advances Chlamydia control activities in the Netherlands. Insight into the feasibility, effectiveness, cost-effectiveness, and impact of this large-scale screening programme will determine whether the programme will be implemented nationally. JF - BMC Infectious Diseases AU - van Bergen, Jan EAM AU - Fennema, Johannes SA AU - van den Broek, Ingrid VF AU - Brouwers, Elfi EHG AU - de Feijter, Eva M AU - Hoebe, Christian JPA AU - Koekenbier, Rik H AU - Op de Coul, Eline LM AU - van Ravesteijn, Sander M AU - Goetz, Hannelore M AD - Rotterdam Rijnmond Public Health Service, Rotterdam, The Netherlands Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - 293 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Microbiology Abstracts B: Bacteriology KW - Risk assessment KW - Databases KW - Data processing KW - Chlamydia trachomatis KW - Infection KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Infectious+Diseases&rft.atitle=Rationale%2C+design%2C+and+results+of+the+first+screening+round+of+a+comprehensive%2C+register-based%2C+Chlamydia+screening+implementation+programme+in+the+Netherlands&rft.au=van+Bergen%2C+Jan+EAM%3BFennema%2C+Johannes+SA%3Bvan+den+Broek%2C+Ingrid+VF%3BBrouwers%2C+Elfi+EHG%3Bde+Feijter%2C+Eva+M%3BHoebe%2C+Christian+JPA%3BKoekenbier%2C+Rik+H%3BOp+de+Coul%2C+Eline+LM%3Bvan+Ravesteijn%2C+Sander+M%3BGoetz%2C+Hannelore+M&rft.aulast=van+Bergen&rft.aufirst=Jan&rft.date=2010-10-07&rft.volume=10&rft.issue=&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=BMC+Infectious+Diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-10-293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Databases; Data processing; Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1186/1471-2334-10-293 ER - TY - JOUR T1 - An in vitro system for studying potential biological mechanisms of human sex differences in susceptibility to acute liver injury. AN - 748976292; 20621171 AB - Women are more susceptible than men to acute liver injury from drugs and other xenobiotics. The biological mechanisms for this sex difference are unknown, but known sex differences in steroid hormone levels and immune response could play a role. A human hepatocyte cell line, HepG2, was cultured for 8 days in either a male hormone, female hormone, or sex hormone-free medium. The cells were then exposed to a mixture of pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6, TNFalpha) for 72h to simulate acute inflammation. Cell viability (total DNA) and various metabolic functions (reactive oxygen species (ROS), neutral and polar lipid (PL) accumulation, mitochondrial membrane potential, cytochrome P450 (CYP) activities) were measured fluorometrically. Acute phase proteins (albumin, IL-1ra) were measured in the culture medium by ELISA. This model gave both significant hormone only effects (ROS, PL accumulation) and cytokine only effects (total DNA, CYP1A, neutral and PL accumulation, albumin, IL-1ra) consistent with known biological responses. Significant hormone-cytokine interactions were observed for several endpoints (total DNA, ROS, neutral and PL accumulation, albumin). These findings suggest that sex hormones and pro-inflammatory cytokines can interact to alter liver metabolism in ways that may contribute to the marked sex difference in susceptibility to chemical-induced acute liver injury. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Flynn, Thomas J AU - Ferguson, Martine S AD - FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States. thomas.flynn@fda.hhs.gov Y1 - 2010/10/05/ PY - 2010 DA - 2010 Oct 05 SP - 232 EP - 236 VL - 198 IS - 2 KW - Acute-Phase Proteins KW - 0 KW - Culture Media KW - Cytokines KW - Gonadal Steroid Hormones KW - Reactive Oxygen Species KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Acute Disease KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Cell Culture Techniques KW - Cytochrome P-450 Enzyme System -- metabolism KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Hep G2 Cells KW - Enzyme-Linked Immunosorbent Assay KW - Acute-Phase Proteins -- metabolism KW - Female KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Cytokines -- pharmacology KW - Sex Characteristics KW - Gonadal Steroid Hormones -- pharmacology KW - Gonadal Steroid Hormones -- metabolism KW - Cytokines -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Chemical and Drug Induced Liver Injury -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748976292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=An+in+vitro+system+for+studying+potential+biological+mechanisms+of+human+sex+differences+in+susceptibility+to+acute+liver+injury.&rft.au=Flynn%2C+Thomas+J%3BFerguson%2C+Martine+S&rft.aulast=Flynn&rft.aufirst=Thomas&rft.date=2010-10-05&rft.volume=285&rft.issue=45&rft.spage=34447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.133579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-10 N1 - Date created - 2010-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2010.07.003 ER - TY - JOUR T1 - Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes AN - 849440225; 13969676 AB - Multi-walled carbon nanotubes (MWCNT) are new manufactured nanomaterials with a wide spectrum of commercial applications. The durability and fiber-like dimensions (mean length 3.9 km long 49 nm diameter) of MWCNT suggest that these fibers may migrate to and have toxicity within the pleural region. To address whether the pleura received a significant and persistent exposure, C57BL/6J mice were exposed by pharyngeal aspiration to 10, 20, 40 and 80 kg MWCNT or vehicle and the distribution of MWCNT penetrations determined at 1, 7, 28 and 56 days after exposure. Following lung fixation and sectioning, morphometric methods were used to determine the distribution of MWCNT and the number of MWCNT fiber penetrations of three barriers: alveolar epithelium (alveolar penetrations), the alveolar epithelium immediately adjacent to the pleura (subpleural tissue), and visceral pleural surface (intrapleural space). At 1 day 18%, 81.6% and 0.6% of the MWCNT lung burden was in the airway, the alveolar, and the subpleural regions, respectively. There was an initial, high density of penetrations into the subpleural tissue and the intrapleural space one day following aspiration which appeared to decrease due to clearance by alveolar macrophages and/or lymphatics by day 7. However, the density of penetrations increased to steady state levels in the subpleural tissue and intrapleural from day 28 - 56. At day 56 approximately 1 in every 400 fiber penetrations was in either the subpleural tissue or intrapleural space. Numerous penetrations into macrophages in the alveolar airspaces throughout the lungs were demonstrated at all times but are not included in the counts presented. The results document that MWCNT penetrations of alveolar macrophages, the alveolar wall, and visceral pleura are both frequent and sustained. In addition, the findings demonstrate the need to investigate the chronic toxicity of MWCNT at these sites. JF - Particle and Fibre Toxicology AU - Mercer, Robert R AU - Hubbs, Ann F AU - Scabilloni, James F AU - Wang, Liying AU - Battelli, Lori A AU - Schwegler-Berry, Diane AU - Castranova, Vincent AU - Porter, Dale W AD - Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA Y1 - 2010/10/04/ PY - 2010 DA - 2010 Oct 04 SP - 28 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Macrophages KW - Pharynx KW - Toxicity KW - Migration KW - Alveoli KW - Fibers KW - Pleura KW - Carbon KW - Lung KW - Chronic toxicity KW - Sectioning KW - nanotubes KW - Epithelium KW - Cell migration KW - nanotechnology KW - Respiratory tract KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849440225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Distribution+and+persistence+of+pleural+penetrations+by+multi-walled+carbon+nanotubes&rft.au=Mercer%2C+Robert+R%3BHubbs%2C+Ann+F%3BScabilloni%2C+James+F%3BWang%2C+Liying%3BBattelli%2C+Lori+A%3BSchwegler-Berry%2C+Diane%3BCastranova%2C+Vincent%3BPorter%2C+Dale+W&rft.aulast=Mercer&rft.aufirst=Robert&rft.date=2010-10-04&rft.volume=7&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Pharynx; Toxicity; Migration; Alveoli; Pleura; Fibers; Carbon; Lung; Chronic toxicity; Sectioning; nanotubes; Epithelium; Cell migration; Respiratory tract; nanotechnology DO - http://dx.doi.org/10.1186/1743-8977-7-28 ER - TY - JOUR T1 - The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment AN - 968157947; 15033742 AB - The Pig-a (phosphatidylinositol glycan, Class A) gene codes for a catalytic subunit of the N-acetylglucosamine transferase complex involved in an early step of glycosylphosphatidyl inositol (GPI) cell surface anchor synthesis. Pig-a is the only gene involved in GPI anchor synthesis that is on the X-chromosome, and research into the origins of an acquired genetic disease involving GPI anchor deficiency (paroxysmal nocturnal hemoglobinuria) indicates that cells lacking GPI anchors, or GPI-anchored cell surface proteins, almost always have mutations in the Pig-a gene. These properties of the Pig-a gene and the GPI anchor system have been exploited in a series of assays for measuring in vivo gene mutation in blood cells from humans, rats, mice, and monkeys. In rats, flow cytometric measurement of Pig-a mutation in red blood cells requires microliter volumes of blood and data can be generated in hours. Spontaneous mutant frequencies are relatively low (<5 X 10-6) and rats treated with multiple doses of the potent mutagen, N-ethyl-N-nitrosourea, display Pig-a mutant frequencies that are close to the sum of the frequencies produced by the individual exposures. A general observation is that induced mutant frequencies are manifested earlier in reticulocytes (about 2 weeks after treatment) than in total red blood cells (about 2 months after exposure). Based on data from a limited number of test agents, the assay shows promise for regulatory applications, including integration of gene mutation measurement into repeat-dose toxicology studies. Environ. Mol. Mutagen., 2010. Published 2010 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Dobrovolsky, Vasily N AU - Miura, Daishiro AU - Heflich, Robert H AU - Dertinger, Stephen D AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, vasily.dobrovolsky@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 825 EP - 835 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 8-9 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts KW - Paroxysmal nocturnal hemoglobinuria KW - Cell surface KW - Mutagens KW - phosphatidylinositol KW - Erythrocytes KW - exploitation KW - Mutant frequency KW - N-Acetylglucosamine KW - Polysaccharides KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Integration KW - Ethyl nitrosourea KW - Glycosylphosphatidylinositol KW - Blood cells KW - Toxicology KW - Data processing KW - Point mutation KW - Assays KW - Catalytic subunits KW - Mice KW - Proteins KW - Mutation KW - Reticulocytes KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968157947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=The+in+vivo+pig-a+gene+mutation+assay%2C+a+potential+tool+for+regulatory+safety+assessment&rft.au=Dobrovolsky%2C+Vasily+N%3BMiura%2C+Daishiro%3BHeflich%2C+Robert+H%3BDertinger%2C+Stephen+D&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2010-10-01&rft.volume=51&rft.issue=8-9&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20627 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20627/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Paroxysmal nocturnal hemoglobinuria; Mutagens; Cell surface; Data processing; phosphatidylinositol; Point mutation; Erythrocytes; Catalytic subunits; Mutant frequency; N-Acetylglucosamine; Polysaccharides; Mutagenesis; Flow cytometry; Integration; Ethyl nitrosourea; Glycosylphosphatidylinositol; Blood cells; Reticulocytes; Rats; Assays; Proteins; Mice; exploitation; Mutation; Toxicology; Mutants DO - http://dx.doi.org/10.1002/em.20627 ER - TY - JOUR T1 - Training Outcomes from the Samaritans of New York Suicide Awareness and Prevention Programme among Community- and School-Based Staff AN - 954599537; 14310363 AB - The Samaritans of New York public education suicide awareness and prevention programme is designed to train lay and professional staff on effective suicide prevention practices and how to 'befriend' a person in crisis. However, little is known about the individual-level characteristics of staff who attend these trainings. Community- and school-based staff (N = 365) completed pre- and post-training measures of self-efficacy regarding their knowledge about suicide and suicide prevention and their ability to intervene with individuals at risk for suicide. Results indicate increased self-efficacy after suicide prevention training (M = 3.7, SD = 0.6) than before (M = 3.3, SD = 0.7) (t = -13.24, p < 0.05). Trainees with higher levels of education and previous contact with suicidal individuals were significantly more likely to indicate gains in self-efficacy after training. JF - British Journal of Social Work AU - Clark, Tanisha R AU - Matthieu, Monica M AU - Ross, Alan AU - Knox, Kerry L AD - Tanisha R. Clark has a BA from Spelman College in Atlanta, Georgia, majoring in psychology, and was an NIMH undergraduate research fellow through Atlanta University Center NIMH-Career Opportunities in Research (AUC NIMH-COR). Ms Clark served as a Research Assistant at the Center for Mental Health Services Research at the George Warren Brown School of Social Work, Washington University in St Louis and the Department of Veterans Affairs Medical Center in St Louis, Missouri, as part of her summer research experience for AUC NIMH-COR. Monica M. Matthieu, Ph.D., LCSW, is a Research Assistant Professor at the George Warren Brown School of Social Work, Washington University in St Louis, and a Research Social Worker at the Department of Veterans Affairs Medical Center in St Louis, Missouri. Alan Ross, M.A., is the Executive Director of the Samaritans of New York, Inc., New York, NY. Kerry L. Knox, Ph.D., is an Associate Professor in the Department of Psychiatry, University of Rochester, mmatthieu@wustl.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2223 EP - 2238 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 40 IS - 7 SN - 0045-3102, 0045-3102 KW - Risk Abstracts KW - Education KW - Training KW - crises KW - prevention KW - suicide KW - USA, New York KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954599537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Social+Work&rft.atitle=Training+Outcomes+from+the+Samaritans+of+New+York+Suicide+Awareness+and+Prevention+Programme+among+Community-+and+School-Based+Staff&rft.au=Clark%2C+Tanisha+R%3BMatthieu%2C+Monica+M%3BRoss%2C+Alan%3BKnox%2C+Kerry+L&rft.aulast=Clark&rft.aufirst=Tanisha&rft.date=2010-10-01&rft.volume=40&rft.issue=7&rft.spage=2223&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Social+Work&rft.issn=00453102&rft_id=info:doi/10.1093%2Fbjsw%2Fbcq016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Education; Training; crises; prevention; suicide; USA, New York DO - http://dx.doi.org/10.1093/bjsw/bcq016 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys AN - 954575103; 13680104 AB - Bisphenol A (BPA) is a high-production volume industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of >90% of Americans aged 6-60 is controversial because of the potential for endocrine disruption, particularly during perinatal development, as suggested by in vitro, experimental animal, and epidemiological studies. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal rhesus monkeys by oral (PND 5, 35, 70) and intravenous injection (PND 77) routes using d6-BPA to avoid sample contamination. The concentration-time profiles observed in adult monkeys following oral administration of 100I14g/kg bw were remarkably similar to those previously reported in human volunteers given a similar dose; moreover, minimal pharmacokinetic differences were observed between neonatal and adult monkeys for the receptor-active aglycone form of BPA. Circulating concentrations of BPA aglycone were quite low following oral administration (< 1% of total), which reflects the redundancy of active UDP-glucuronosyl transferase isoforms in both gut and liver. No age-related changes were seen in internal exposure metrics for aglycone BPA in monkeys, a result clearly different from developing rats where significant inverse age-related changes, based on immaturity of Phase II metabolism and renal excretion, were recently reported. These observations imply that any toxicological effect observed in rats from early postnatal exposures to BPA could over-predict those possible in primates of the same age, based on significantly higher internal exposures and overall immaturity at birth. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Woodling, Kellie A AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, daniel.doerge@fda.hhs.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 1 EP - 11 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 248 IS - 1 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Aglycones KW - Macaca mulatta KW - Neonates KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+neonatal+and+adult+rhesus+monkeys&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BWoodling%2C+Kellie+A%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2010-10-01&rft.volume=248&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Aglycones; Neonates; Macaca mulatta DO - http://dx.doi.org/10.1016/j.taap.2010.07.009 ER - TY - JOUR T1 - Simple Respiratory Protection-Evaluation of the Filtration Performance of Cloth Masks and Common Fabric Materials Against 20-1000 nm Size Particles AN - 899129103; 13842714 AB - A shortage of disposable filtering facepiece respirators can be expected during a pandemic respiratory infection such as influenza A. Some individuals may want to use common fabric materials for respiratory protection because of shortage or affordability reasons. To address the filtration performance of common fabric materials against nano-size particles including viruses, five major categories of fabric materials including sweatshirts, T-shirts, towels, scarves, and cloth masks were tested for polydisperse and monodisperse aerosols (20-1000 nm) at two different face velocities (5.5 and 16.5 cm s-1) and compared with the penetration levels for N95 respirator filter media. The results showed that cloth masks and other fabric materials tested in the study had 40-90% instantaneous penetration levels against polydisperse NaCl aerosols employed in the National Institute for Occupational Safety and Health particulate respirator test protocol at 5.5 cm s-1. Similarly, varying levels of penetrations (9-98%) were obtained for different size monodisperse NaCl aerosol particles in the 20-1000 nm range. The penetration levels of these fabric materials against both polydisperse and monodisperse aerosols were much higher than the penetrations for the control N95 respirator filter media. At 16.5 cm s-1 face velocity, monodisperse aerosol penetrations slightly increased, while polydisperse aerosol penetrations showed no significant effect except one fabric mask with an increase. Results obtained in the study show that common fabric materials may provide marginal protection against nanoparticles including those in the size ranges of virus-containing particles in exhaled breath. JF - Annals of Occupational Hygiene AU - Rengasamy, Samy AU - Eimer, Benjamin AU - Shaffer, Ronald E AD - National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory-Technology Research Branch, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 789 EP - 798 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 7 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Particle size KW - Aerosols KW - Viruses KW - Velocity KW - Particulates KW - Protective equipment KW - Fabrics KW - Filtration KW - Respirators KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Simple+Respiratory+Protection-Evaluation+of+the+Filtration+Performance+of+Cloth+Masks+and+Common+Fabric+Materials+Against+20-1000+nm+Size+Particles&rft.au=Rengasamy%2C+Samy%3BEimer%2C+Benjamin%3BShaffer%2C+Ronald+E&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2010-10-01&rft.volume=54&rft.issue=7&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Particle size; Fabrics; Filtration; Aerosols; Viruses; Velocity; Particulates; Respirators; Protective equipment ER - TY - JOUR T1 - Occupational Fatalities in the United States Commercial Fishing Industry, 2000-2009 AN - 888110536; 15523721 AB - The occupational fatality rate among commercial fishermen decreased in the United States during 1992-2008; however, commercial fishing continues to be one of the most dangerous occupations in the United States, with an average annual fatality rate of 129 deaths per 100,000 fishermen in 2008. By contrast, the average annual occupational fatality rate among all US workers during the same period was four deaths per 100,000 workers. During the 1990s, numerous safety interventions were developed for Alaska fisheries that resulted in a significant decline in the state's commercial fishing fatality rate. In 2007, the National Institute for Occupational Safety and Health (NIOSH) expanded surveillance of commercial fishing fatalities to the rest of the United States. The purpose of this report is to identify the hazards and risk factors for all causes of occupational mortality in the US commercial fishing industry, and to explore how those hazards and risk factors differ among fisheries and locations. During 2000-2009, 504 commercial fishing fatalities occurred in the United States. Most (261, 52%) occurred following a vessel disaster (defined as a sinking, capsizing, or other event in which the crew was forced to abandon ship) or a fall overboard (155, 31%). Fatalities occurred in Alaska (133, 26%), Northeast (124, 25%), Gulf of Mexico (116, 23%), West Coast (83, 16%), and the Mid- and South Atlantic (41, 8%) regions. Fatalities occurred most commonly while fishing for shellfish (226, 47%), groundfish (144, 30%) and pelagic fish (97, 20%). Average annual fatality rates were calculated for selected fisheries. The Northeast multispecies groundfish fleet had the highest average annual fatality rate (600 deaths per 100,000 full-time equivalent [FTE] fishermen) followed by the Atlantic scallop fleet (425 deaths per 100,000 FTE fishermen) and the West Coast Dungeness crab fleet (310 deaths per 100,000 FTE fishermen). To reduce fatalities among fishermen at greatest risk, additional prevention measures tailored to specific high-risk fisheries should be considered. JF - Journal of Agromedicine AU - Lincoln, Jennifer M AU - Lucas, Devin L AD - Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Alaska Pacific Regional Office, Anchorage, Alaska, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 343 EP - 350 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 4 SN - 1059-924X, 1059-924X KW - ASFA 1: Biological Sciences & Living Resources; Risk Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Health & Safety Science Abstracts KW - Ships KW - Biological surveys KW - Mortality KW - Fishing vessels KW - Decapoda KW - Settling rate KW - Crustacea KW - Disasters KW - AS, South Atlantic KW - INE, USA, Alaska KW - Fishery development KW - ASW, Mexico Gulf KW - Hazards KW - Commercial fishing KW - Risk factors KW - Fisheries KW - Depleted stocks KW - Fish KW - Shellfish KW - Mortality causes KW - Q5 08504:Effects on organisms KW - Q1 08442:Population dynamics KW - O 5020:Fisheries and Fishery Biology KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888110536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Occupational+Fatalities+in+the+United+States+Commercial+Fishing+Industry%2C+2000-2009&rft.au=Lincoln%2C+Jennifer+M%3BLucas%2C+Devin+L&rft.aulast=Lincoln&rft.aufirst=Jennifer&rft.date=2010-10-01&rft.volume=15&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.509700 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Biological surveys; Hazards; Commercial fishing; Fishing vessels; Settling rate; Depleted stocks; Disasters; Fishery development; Mortality causes; Ships; Mortality; Crustacea; Risk factors; Fisheries; Shellfish; Fish; Decapoda; ASW, Mexico Gulf; INE, USA, Alaska; AS, South Atlantic DO - http://dx.doi.org/10.1080/1059924X.2010.509700 ER - TY - JOUR T1 - pH effect on the synthesis, shear properties, and homogeneity of iron-crosslinked hyaluronic acid-based gel/adhesion barrier AN - 883045941; 15243612 AB - Iron-crosslinked hyaluronic acid hydrogel (FeHA) has been used to reduce postsurgical adhesions in patients undergoing open, gynecological surgery. The performance of FeHA gel as an adhesion barrier device is influenced by many factors, including the physicochemical gel properties, which, in turn, depend on the chemistry and conditions of the device manufacturing. In this work, we demonstrate the effect of reaction pH on rheology and homogeneity of FeHA gels formulated in house and also compare the viscoelastic properties of FeHA gels with that of uncrosslinked HA solution of similar HA concentration and ionic strength. Dynamic mechanical analyses provide evidence that the reaction of HA with Fe(III) ions leads to the formation of 'weak' gels. The viscoelastic properties and homogeneity of FeHA gels vary depending on the pH at which crosslinking was initiated. When solution pH, at the start of crosslinking, varied between 1.5 and 3, the low-shear rate viscosity of FeHA varied between 10,000 and 40,000 cPoise (10-40 Pa s). The highest steady-state shear viscosity and viscoelasticity were measured when pH was around 2.6, which is similar to the pH-dependent viscoelasticity of pure HA solution. Initiating HA crosslinking at pH 3 caused instantaneous gel precipitation and inhomogeneities. Sensitivity of FeHA gel properties to small variations in reaction pH clearly supports the need for a tight manufacturing control during medical device fabrication. [copy 2010 Wiley Periodicals, Inc.* J Biomed Mater Res Part B: Appl Biomater, 2010. JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Isayeva, Irada AU - Das, Srilekha Sarkar AU - Chang, Andrew AU - Defoe, Jacqueline AU - Do Luu, Hoan-My AU - Vorvolakos, Katherine AU - Patwardhan, Dinesh AU - Whang, Joyce AU - Pollack, Steven AD - Division of Chemistry and Materials Science (DCMS)/Office of Science and Engineering Laboratories (OSEL)/Center for Devices and Radiological Health (CDRH)/Food and Dug Administration (FDA), Silver Spring, Maryland 20903, irada.isayeva@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 9 EP - 18 PB - Wiley-Blackwell VL - 95B IS - 1 SN - 1552-4981, 1552-4981 KW - Biotechnology and Bioengineering Abstracts KW - Ions KW - Hyaluronic acid KW - Gel precipitation KW - Rheology KW - Houses KW - Viscosity KW - hydrogels KW - Ionic strength KW - Surgery KW - pH effects KW - viscoelasticity KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883045941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=pH+effect+on+the+synthesis%2C+shear+properties%2C+and+homogeneity+of+iron-crosslinked+hyaluronic+acid-based+gel%2Fadhesion+barrier&rft.au=Isayeva%2C+Irada%3BDas%2C+Srilekha+Sarkar%3BChang%2C+Andrew%3BDefoe%2C+Jacqueline%3BDo+Luu%2C+Hoan-My%3BVorvolakos%2C+Katherine%3BPatwardhan%2C+Dinesh%3BWhang%2C+Joyce%3BPollack%2C+Steven&rft.aulast=Isayeva&rft.aufirst=Irada&rft.date=2010-10-01&rft.volume=95B&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=15524981&rft_id=info:doi/10.1002%2Fjbm.b.31677 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31677/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Hyaluronic acid; Ions; Houses; Rheology; Gel precipitation; Viscosity; Ionic strength; hydrogels; Surgery; pH effects; viscoelasticity DO - http://dx.doi.org/10.1002/jbm.b.31677 ER - TY - RPRT T1 - A Year in Head Start: Children, Families and Programs. ACF-ORPRE Report AN - 864941911; ED517213 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers and program managers, as well as direct observations of classroom quality. This brief profiles the 3- and 4-year-old Head Start children and families who were newly enrolled in the program in fall 2006 (see Tarullo et al. 2008) and are still attending in spring 2007. The first section of the report provides background on the study methodology and sample. The next offers information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. It includes information on parent involvement in Head Start and level of satisfaction with their own and their children's Head Start experiences. The following section chronicles children's developmental progress over the Head Start year, considering whether these outcomes vary by age, gender, race/ethnicity, or risk status. Changes in children's skills and development during the program year reflect a range of influences, including maturation, program and family influences, and other influences in children's lives. Presented next are the characteristics of their teachers and classrooms, including measures of observed quality. Finally, the last section examines the relationships among child, family, and classroom factors and children's outcomes. (Contains 2 tables, 16 figures and 52 notes.) [For related report, "Data Tables for FACES 2006: A Year in Head Start Report. ACF-ORPRE Report", see ED517209.] AU - Aikens, Nikki AU - Tarullo, Louisa AU - Hulsey, Lara AU - Ross, Christine AU - West, Jerry AU - Xue, Yange Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 41 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Teacher Characteristics KW - Educational Indicators KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Standardized Tests KW - Achievement Gains KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Educational Environment KW - Classroom Observation Techniques KW - Child Development KW - Parent Participation KW - Parent Attitudes KW - Program Evaluation KW - Interviews KW - Educational Assessment KW - Preschool Evaluation KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941911?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Data Tables for FACES 2006: A Year in Head Start Report. ACF-ORPRE Report AN - 864941411; ED517209 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers and program managers, as well as direct observations of classroom quality. This set of tables is designed to accompany a research brief which profiles the 3- and 4-year-old Head Start children and families who were newly enrolled in the program in fall 2006 and are still attending in spring 2007 (see Aikens et al. 2010). Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status in spring 2007. These tables also include information on parent involvement in Head Start and level of satisfaction with their own and their children's Head Start experiences. The next sections, on cognitive and social-emotional/health outcomes in spring 2007, chronicle children's developmental progress over the Head Start year. They examine whether these outcomes vary by age, gender, race/ethnicity, or risk status. The following section presents the characteristics of their teachers and classrooms, including measures of observed quality in spring 2007. Subsequent sections provide information on fall-spring change in family environment, child cognitive, social-emotional, and health outcomes. The next section examines the relationships among child, family, and classroom factors and children's outcomes; the methods used for those analyses appear in advance of the tables in that section. The final section provides tables of standard deviations and standard errors. (Contains 183 tables and 12 footnotes.) [For related report, "A Year in Head Start: Children, Families and Programs. ACF-ORPRE Report", see ED517213.] AU - Hulsey, Lara AU - Aikens, Nikki AU - Xue, Yange AU - Tarullo, Louisa AU - West, Jerry Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 227 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Classroom Environment KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Demography KW - Classroom Observation Techniques KW - Child Development KW - Statistical Data KW - Program Evaluation KW - Population Trends KW - Preschool Evaluation KW - Family Environment KW - Gender Differences KW - Teacher Characteristics KW - Racial Differences KW - Achievement Gains KW - Educational Environment KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941411?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Conceptual Frameworks for Child Care Decision-Making. White Paper AN - 864939896; ED517547 AB - This working paper is one in a series of projects initiated by the Administration for Children and Families (ACF) to improve knowledge for child care researchers and policy makers about parental child care decision making. In this paper, the authors identify three distinct conceptual frameworks for understanding child care decisions--a rational consumer choice framework, a heuristics and biases framework, and a social network framework--and review the major assumptions, contributions, and possible limitations of each of these frameworks. They then discuss an integrated conceptual model, the accommodation model that draws from each of these frameworks. The first three frameworks come primarily from the fields of economics, psychology, and sociology, respectively. It is the authors' sense that most research about child care decision making has been informed by the theories, assumptions, and empirical methods of one or more of these frameworks, either explicitly or implicitly, and they provide some examples and elaborate the basic tenets of each framework. The integrative accommodation model was first presented by Marcia Meyers and Lucy Jordan (2006). They develop and elaborate this model more fully here with explicit attention to its relation to the rational consumer choice framework, the heuristics and biases framework, and the social network frameworks. These frameworks are presented as complementary, rather than mutually exclusive. For a process as complex as parental child care decisions, each can provide a different and useful lens through which to understand unique aspects of the factors, processes and outcomes of parental child care decisions. When considered together, they believe they may inform one another and the development of more integrative models, such as the accommodation model presented here. It is the authors' hope that researchers working primarily within one of the conceptual frameworks discussed here will benefit from learning about other frameworks. In some cases, this may simply suggest additional or new variables to consider when specifying a particular model, while still working from the same conceptual framework. In other cases, it may result in integrative approaches that address multiple dimensions of the decision making process--dimensions that may not be as obvious when working within a single framework. In the concluding section the authors discuss some of the issues and the implications for future research. A goal of this paper is to advance knowledge that can inform public policy efforts. Given that the Child Care Development Fund (CCDF) has an explicit goal of supporting parental choice for child care, it is critical that they expand and deepen everyone's knowledge about the processes through which parents make decisions and the consequences for the choices they make (Zaslow, Halle, Guzman, Lavelle, Keith, Berry, & Dent, 2006). The different perspectives offered by each of the three frameworks and the integrative accommodation model may help policy makers identify the policy and program levers that can prove important at different stages of the decision making process. (Contains 7 footnotes.) AU - Chaudry, Ajay AU - Henly, Julia AU - Meyers, Marcia Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 44 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Social Influences KW - Context Effect KW - Sociology KW - Heuristics KW - Psychology KW - Child Care KW - Public Policy KW - Decision Making KW - Models KW - Holistic Approach KW - Social Attitudes KW - Economics KW - Researchers KW - Theories KW - Social Networks KW - Parents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864939896?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Protecting the planet and its people: How do interventions to promote environmental sustainability and occupational safety and health overlap? AN - 856762591; 13998130 AB - Problem: The challenges of both occupational safety and health and environmental sustainability require large-scale behavior change for meaningful improvements to occur. Environmental sustainability, or the 'green movement' has received far more attention recently, and certain strategies and recommendations from interventions designed for promoting pro-environmental behaviors may inform efforts to intervene on critical behaviors for improving occupational safety and health. Method: A survey of the literature regarding behavioral interventions for both environmental sustainability and occupational safety and health was conducted. Several theoretical approaches are reviewed, and successful approaches from each domain are identified, as well as parallel challenges and points for crossover. Recommendations are provided for adapting environmental sustainability intervention approaches for occupational safety and health applications. Impact on Industry: Safety and health leaders may achieve sustainable improvements in worker safety and health by harnessing the momentum of the green movement and adapting successful intervention approaches from the environmental sustainability domain. JF - Journal of Safety Research AU - Cunningham, Thomas R AU - Galloway-Williams, Neville AU - Geller, EScott AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-10, Cincinnati, OH 45226, tcunningham@cdc.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 407 EP - 416 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 5 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Occupational safety KW - Sustainable development KW - green revolution KW - adaptability KW - intervention KW - Reviews KW - sustainability KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856762591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Pharmacogenomics+and+adverse+drug+reactions&rft.au=Amur%2C+Shashi%3BZineh%2C+Issam%3BAbernethy%2C+Darrell+R%3BHuang%2C+Shiew-Mei%3BLesko%2C+Lawrence+J&rft.aulast=Amur&rft.aufirst=Shashi&rft.date=2010-11-01&rft.volume=7&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/10.2217%2Fpme.10.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Reviews; intervention; Occupational safety; Sustainable development; green revolution; sustainability; adaptability DO - http://dx.doi.org/10.1016/j.jsr.2010.08.002 ER - TY - JOUR T1 - Assessing the performance of various restraints on ambulance patient compartment workers during crash events AN - 855695980; 14060115 AB - The inability of emergency medical service (EMS) workers to remain safely restrained while treating patients in the patient compartment of a moving ambulance has been identified as a key impediment to EMS worker safety in North America. It has been hypothesised that restraint systems designed to provide mobility while offering the ability to lock during an impact or sudden manoeuvre, could greatly enhance worker safety in the back of ambulances. Through a series of 33 sled and crash tests impacting the front, side, and rear of simulated and actual ambulance patient compartments, the National Institute for Occupational Safety and Health examined the biomechanical and kinematic effects of two-, four- and five-point restraints on 95th percentile male Hybrid III anthropomorphic test devices. Results indicate that the inclusion of restraint systems offering mobility have the potential to improve worker safety under many working conditions in this unique work environment. JF - International Journal of Crashworthiness AU - Green, J D AU - Yannaccone, J R AU - Current, R S AU - Sicher, LA AU - Moore, PH AU - Whitman, G R AD - National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 517 EP - 541 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 15 IS - 5 SN - 1358-8265, 1358-8265 KW - Health & Safety Science Abstracts KW - crash testing KW - restraints KW - neck injury KW - head injury criteria (HIC) KW - side-facing seating KW - crashworthiness KW - North America KW - hybrids KW - Mobility KW - Occupational safety KW - biomechanics KW - emergency medical services KW - working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855695980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Crashworthiness&rft.atitle=Assessing+the+performance+of+various+restraints+on+ambulance+patient+compartment+workers+during+crash+events&rft.au=Green%2C+J+D%3BYannaccone%2C+J+R%3BCurrent%2C+R+S%3BSicher%2C+LA%3BMoore%2C+PH%3BWhitman%2C+G+R&rft.aulast=Green&rft.aufirst=J&rft.date=2010-10-01&rft.volume=15&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Crashworthiness&rft.issn=13588265&rft_id=info:doi/10.1080%2F13588265.2010.489402 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 51 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - crashworthiness; hybrids; Mobility; biomechanics; Occupational safety; working conditions; emergency medical services; North America DO - http://dx.doi.org/10.1080/13588265.2010.489402 ER - TY - JOUR T1 - Information-Theoretic Approach for Analyzing Bias and Variance in Lung Nodule Size Estimation With CT: A Phantom Study AN - 855690743; 14109016 AB - This work is a part of our more general effort to probe the interrelated factors impacting the accuracy and precision of lung nodule measurement tasks. For such a task a low-bias size estimator is needed so that the true effect of factors such as acquisition and reconstruction parameters, nodule characteristics and others can be assessed. Towards this goal, we have developed a matched filter based on an adaptive model of the object acquisition and reconstruction process. Our model derives simulated reconstructed data of nodule objects (templates) which are then matched to computed tomography data produced from imaging the actual nodule in a phantom study using corresponding imaging parameters. This approach incorporates the properties of the imaging system and their effect on the discrete 3-D representation of the object of interest. Using a sum of absolute differences cost function, the derived matched filter demonstrated low bias and variance in the volume estimation of spherical synthetic nodules ranging in density from - 630 to + 100 ~ rm HU and in size from 5 to 10 mm. This work could potentially lead to better understanding of sources of error in the task of lung nodule size measurements and may lead to new techniques to account for those errors. JF - IEEE Transactions on Medical Imaging AU - Gavrielides, Marios A AU - Zeng, Rongping AU - Kinnard, Lisa M AU - Myers, Kyle J AU - Petrick, Nicholas AD - Division of Imaging and Applied Mathematics (DIAM), Office of Science and Engineering Laboratories (OSEL), Center for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1795 EP - 1807 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 29 IS - 10 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Data processing KW - Computed tomography KW - Lung nodules KW - Probes KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855690743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Information-Theoretic+Approach+for+Analyzing+Bias+and+Variance+in+Lung+Nodule+Size+Estimation+With+CT%3A+A+Phantom+Study&rft.au=Gavrielides%2C+Marios+A%3BZeng%2C+Rongping%3BKinnard%2C+Lisa+M%3BMyers%2C+Kyle+J%3BPetrick%2C+Nicholas&rft.aulast=Gavrielides&rft.aufirst=Marios&rft.date=2010-10-01&rft.volume=29&rft.issue=10&rft.spage=1795&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2052466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Filters; Data processing; Computed tomography; Probes; Lung nodules; Models DO - http://dx.doi.org/10.1109/TMI.2010.2052466 ER - TY - JOUR T1 - Considerations for Clinical Trial Design and Data Analyses of Thorough QT Studies Using Drug-Drug Interaction AN - 853480026; 14088395 JF - Journal of Clinical Pharmacology AU - Zhu, Hao AU - Wang, Yaning AU - Gobburu, Jogarao V AU - Garnett, Christine E AD - Division of Pharmacometrics, Office of Clinical Pharmacology, CDER, Food and Drug Administration, Silver Spring, Maryland, Hao.Zhu@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1106 EP - 1111 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 50 IS - 10 SN - 0091-2700, 0091-2700 KW - Health & Safety Science Abstracts KW - clinical trials KW - drug interaction KW - Design KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853480026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Considerations+for+Clinical+Trial+Design+and+Data+Analyses+of+Thorough+QT+Studies+Using+Drug-Drug+Interaction&rft.au=Zhu%2C+Hao%3BWang%2C+Yaning%3BGobburu%2C+Jogarao+V%3BGarnett%2C+Christine+E&rft.aulast=Zhu&rft.aufirst=Hao&rft.date=2010-10-01&rft.volume=50&rft.issue=10&rft.spage=1106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270009358710 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - clinical trials; drug interaction; Design DO - http://dx.doi.org/10.1177/0091270009358710 ER - TY - JOUR T1 - Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers AN - 839687391; 13984200 AB - Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drags. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Results: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drags measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Conclusions: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations. JF - Journal of Occupational and Environmental Medicine AU - Connor, TH AU - DeBord, D G AU - Pretty, J R AU - Oliver AU - Roth, T S AU - Lees, PSJ AU - Krieg, EF Jr AU - Rogers, B AU - Escalante, C P AU - Toennis, CA AU - Clark, J C AU - Johnson, B C AU - McDiarmid, MA AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, tmc6@cdc.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1019 EP - 1027 VL - 52 IS - 10 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts KW - 5-Fluorouracil KW - Contamination KW - Urine KW - Nursing KW - Antineoplastic drugs KW - Comet assay KW - Cyclophosphamide KW - Drugs KW - Occupational exposure KW - Medical personnel KW - Cancer KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839687391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Evaluation+of+Antineoplastic+Drug+Exposure+of+Health+Care+Workers+at+Three+University-Based+US+Cancer+Centers&rft.au=Connor%2C+TH%3BDeBord%2C+D+G%3BPretty%2C+J+R%3BOliver%3BRoth%2C+T+S%3BLees%2C+PSJ%3BKrieg%2C+EF+Jr%3BRogers%2C+B%3BEscalante%2C+C+P%3BToennis%2C+CA%3BClark%2C+J+C%3BJohnson%2C+B+C%3BMcDiarmid%2C+MA&rft.aulast=Connor&rft.aufirst=TH&rft.date=2010-10-01&rft.volume=52&rft.issue=10&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181f72b63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - 5-Fluorouracil; Contamination; Urine; Nursing; Antineoplastic drugs; Cyclophosphamide; Comet assay; Drugs; Cancer; Medical personnel; Occupational exposure DO - http://dx.doi.org/10.1097/JOM.0b013e3181f72b63 ER - TY - JOUR T1 - Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin AN - 839678977; 13913485 AB - The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly higher in steers than in cows (metabolite ratio: 64% and 59%, respectively). There was no significant difference in plasma protein binding of enrofloxacin between cows (percent bound: 59.4%) and steers (percent bound: 60.8%). Ciprofloxacin was more extensively bound to plasma proteins in steers (percent bound: 49.6%) than in cows (percent bound: 33.8%). The steady state volume of distribution of enrofloxacin is comparable in cows (1.55 L/kg) and steers (1.59 L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin. JF - Research in Veterinary Science AU - Idowu, O R AU - Peggins, JO AU - Cullison, R AU - Von Bredow, J Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 230 EP - 235 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY UK VL - 89 IS - 2 SN - 0034-5288, 0034-5288 KW - Toxicology Abstracts KW - Enrofloxacin KW - Ciprofloxacin KW - Pharmacokinetics KW - Lactating cows KW - Steers KW - Plasma proteins KW - Intravenous administration KW - Dairies KW - Milk KW - Beef KW - Metabolites KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839678977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Veterinary+Science&rft.atitle=Comparative+pharmacokinetics+of+enrofloxacin+and+ciprofloxacin+in+lactating+dairy+cows+and+beef+steers+following+intravenous+administration+of+enrofloxacin&rft.au=Idowu%2C+O+R%3BPeggins%2C+JO%3BCullison%2C+R%3BVon+Bredow%2C+J&rft.aulast=Idowu&rft.aufirst=O&rft.date=2010-10-01&rft.volume=89&rft.issue=2&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Research+in+Veterinary+Science&rft.issn=00345288&rft_id=info:doi/10.1016%2Fj.rvsc.2009.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2014-09-05 N1 - SubjectsTermNotLitGenreText - Plasma proteins; Ciprofloxacin; Dairies; Intravenous administration; Milk; Enrofloxacin; Beef; Metabolites; Pharmacokinetics DO - http://dx.doi.org/10.1016/j.rvsc.2009.12.019 ER - TY - JOUR T1 - Evaluation of Guillain-Barre Syndrome Among Recipients of Influenza Vaccine in 2000 and 2001 AN - 822497509; 201031349 AB - The 1976-1977 swine influenza vaccine was associated with an elevated risk of Guillain-Barre Syndrome (GBS), especially within 6 weeks after vaccination. A 2004 IOM report concluded that evidence was inadequate to accept or reject a causal relationship between subsequent influenza vaccine formulations and GBS. Studies published after the IOM report have been limited by passively reported data or lack of validation of coded diagnoses. Objective: To evaluate whether influenza vaccine is associated with GBS. Methods: Controlled observational study using national data from the Medicare program, which ensures a predominantly elderly population. People included had a Medicare claim for influenza vaccination during September-December in 2000 or 2001. Medical records were reviewed to classify definite, probable, or possible GBS (or not a case) using a standardized case definition. In a risk interval design, the incidence rate of GBS during Weeks 0-6 after vaccination (exposed period) was compared to Weeks 9-14 after vaccination (comparison period). Data collection occurred during 2003-2007, and analysis was conducted during 2007-2009. Results: Primary analysis included 22.2 million vaccinees, among whom 164 definite or probable GBS cases with onset during Weeks 0-6 or 9-14 were identified. The incidence rate ratio (IRR [95% CIs]) based on the GBS rate in the vaccine-exposed versus comparison periods, was 1.04 (0.76, 1.43) for combined years; 0.86 (0.52, 1.41) among people vaccinated in 2000; and 1.21 (0.79, 1.86) among people vaccinated in 2001. Secondary analysis additionally included 74 possible GBS cases; results were similar. Conclusions: Overall, the results do not support an association between influenza vaccine receipt and GBS among the elderly for the years studied (2000-2001 and 2001-2002 formulations). [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Burwen, Dale R AU - Ball, Robert AU - Bryan, Wilson W AU - Izurieta, Hector S AU - La Voie, Lawrence AU - Gibbs, Neville A AU - Kliman, Rebecca AU - Braun, M Miles AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland dale.burwen@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 296 EP - 304 PB - Elsevier Science, New York NY VL - 39 IS - 4 SN - 0749-3797, 0749-3797 KW - Influenza KW - Elderly people KW - Guillain-Barre syndrome KW - Medicare KW - Vaccines KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Evaluation+of+Guillain-Barre+Syndrome+Among+Recipients+of+Influenza+Vaccine+in+2000+and+2001&rft.au=Burwen%2C+Dale+R%3BBall%2C+Robert%3BBryan%2C+Wilson+W%3BIzurieta%2C+Hector+S%3BLa+Voie%2C+Lawrence%3BGibbs%2C+Neville+A%3BKliman%2C+Rebecca%3BBraun%2C+M+Miles&rft.aulast=Burwen&rft.aufirst=Dale&rft.date=2010-10-01&rft.volume=39&rft.issue=4&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.05.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Influenza; Vaccines; Immunization; Guillain-Barre syndrome; Medicare; Elderly people DO - http://dx.doi.org/10.1016/j.amepre.2010.05.022 ER - TY - JOUR T1 - Factors Associated with the Prevalence of Non-ROPS Tractors on Farms in the U.S. AN - 821736678; 14029798 AB - Rollover protective structures (ROPS) are an effective engineering control known to prevent tractor overturn deaths, the leading cause of occupational fatalities for farmers and farm workers in the U.S. However, the use of ROPS is known to vary greatly from farm to farm. A national sample of 11,458 farm operators from the 2004 Occupational Injury Surveillance of Production Agriculture (OISPA) survey was used to assess the association between the prevalence of ROPS and ten farm operator and farm demographic variables using logistic regression. The variable were: operator's age, operator's sex, operator's education, farm sales, full- or part-time farming, acreage, type of operation, number of hired workers, number of injuries, and region. All ten variables were found to have significant associations with the prevalence of non-ROPS tractors on farms in the univariate logistic regressions. For the multivariate model, all variables except for the sex of the farm operator remained significant. Farms with less than three adult injuries, no hired workers, less than 300 acres in size, a Midwest location, and a primary farm type of tobacco, fruit and nuts, dairy, or poultry and eggs all had adjusted odds ratios of 2 or greater. Increasing the prevalence of ROPS-equipped tractors is essential for reducing the leading cause of death on farms, tractor overturns. Economic factors play a major role in the prevalence and distribution of non-ROPS tractors on farms. The identified associations can be used to effectively target areas of the U.S. for ROPS promotion activities. JF - Journal of Agricultural Safety and Health AU - Myers, J R AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA, jrmyers@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 265 EP - 278 VL - 16 IS - 4 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Education KW - Dairies KW - safety engineering KW - Injuries KW - farms KW - fruits KW - Tobacco KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821736678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Factors+Associated+with+the+Prevalence+of+Non-ROPS+Tractors+on+Farms+in+the+U.S.&rft.au=Myers%2C+J+R&rft.aulast=Myers&rft.aufirst=J&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Mortality; Dairies; Education; safety engineering; Injuries; farms; fruits; Tobacco; Agricultural equipment; USA ER - TY - JOUR T1 - Injury Surveillance for Youth on Farms in the U.S., 2006 AN - 821736131; 14029799 AB - In order to provide injury surveillance for youth on farms in the U.S., the National Institute for Occupational Safety and Health (NIOSH), in partnership with the USDA, developed the Childhood Agricultural Injury Survey (CAIS). CAIS data for all youth less than 20 years of age on farms have been collected for the calendar years of 1998, 2001, 2004, and 2006. CAIS data from 2006 indicated that an estimated 30.7 million youth lived on, worked on, or visited U.S. farms. These youth experienced almost 23,000 injuries while on the farm. The majority of these injuries occurred to males (15,223) and youth between the ages of 10 and 15 years (10,158). Approximately 25% (5,773) of the injuries were related to work being done on the farm. Youth living on the farm incurred 51% (11,654) of the injuries, hired youth sustained 6% (1,363), and 40% were to visiting youth (9,729). Although youth injuries on farms have declined by 30% since 1998, the numbers are still unacceptably high. Further indepth evaluation of subsets of the youth population may serve to better direct safety intervention programs and research. JF - Journal of Agricultural Safety and Health AU - Hendricks, K J AU - Goldcamp, E M AD - Division of Safety Research, National Institute for Occupational Safety and Health, M/S 1808, 1095 Willowdale Rd., Morgantown, WV 26505, USA, Khendricks@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 279 EP - 291 VL - 16 IS - 4 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - USA KW - Age KW - Injuries KW - farms KW - intervention KW - Occupational safety KW - Children KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821736131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Injury+Surveillance+for+Youth+on+Farms+in+the+U.S.%2C+2006&rft.au=Hendricks%2C+K+J%3BGoldcamp%2C+E+M&rft.aulast=Hendricks&rft.aufirst=K&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Age; Injuries; intervention; farms; Occupational safety; Children; USA ER - TY - JOUR T1 - Rising To The Challenge: Tools For Enrolling Eligible Children In Health Coverage AN - 818792638; 2010-643702 AB - Nearly five million uninsured children in the United States are currently eligible for Medicaid or the Children's Health Insurance Program (CHIP) but are not enrolled in these programs. A top Obama administration priority is to achieve the long-sought goal of ensuring that uninsured children are enrolled& that they stay enrolled for as long as they are eligible. The author, who is secretary of the U.S. Department of Health & Human Services (HHS), outlines measures that HHS & other federal agencies are implementing to reach this goal. She also cites existing state efforts to enroll more children & improve children's coverage, & she describes steps that states, local governments, & the private sector can take to expand outreach efforts, increase enrollment, & keep eligible children covered. Adapted from the source document. JF - Health Affairs AU - Sebelius, Kathleen AD - US Dept Health & Human Services, Washington, DC healthcare@hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1930 EP - 1932 PB - Project HOPE, Bethesda MD VL - 29 IS - 10 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Insurance KW - Government - Local and municipal government KW - Children's Health KW - Children KW - Obama, Barack KW - United States KW - Uninsured persons KW - Local government KW - Health insurance KW - Health policy KW - Child health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818792638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Rising+To+The+Challenge%3A+Tools+For+Enrolling+Eligible+Children+In+Health+Coverage&rft.au=Sebelius%2C+Kathleen&rft.aulast=Sebelius&rft.aufirst=Kathleen&rft.date=2010-10-01&rft.volume=29&rft.issue=10&rft.spage=1930&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0852 LA - English DB - PAIS Index N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child health; Health insurance; Uninsured persons; United States; Health policy; Obama, Barack; Local government DO - http://dx.doi.org/10.1377/hlthaff.2010.0852 ER - TY - JOUR T1 - Endothelial Function, a Biomarker of Subclinical Cardiovascular Disease, in Urban Police Officers AN - 817611223; 13984197 AB - Objective: Police officers were hypothesized to have decreased endothelial function, measured by brachial artery flow-mediated dilation (FMD). Methods: We compared FMD in police officers (n = 261) and a population sample of men and women (n = 229), all from the same geographical region and free of clinical cardiovascular disease (CVD). Results: Compared with the population sample, police officers had significantly increased age-adjusted CVD risk factors (systolic and diastolic blood pressure, total cholesterol, smoking prevalence, and alcohol consumption). Police officers exhibited lower mean FMD after adjustment for age, gender, and traditional CVD risk factors among those aged 55 years or younger (%dilation: police = 5.49%, population = 6.49%; P = 0.04). Conclusions: Police officers exhibited decreased endothelial function (lower FMD) compared with the civilian sample, which was not fully explained by traditional CVD risk factors, suggesting that other pathways may contribute to increased CVD risk in law enforcement work. JF - Journal of Occupational and Environmental Medicine AU - Joseph, P N AU - Violanti, J M AU - Donahue, R AU - Andrew, ME AU - Trevisan, M AU - Burchfiel, C M AU - Dorn, J AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road M/S 4050, Morgantown, WV 26505, USA, nedrajoseph@hotmail.com Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1004 EP - 1008 VL - 52 IS - 10 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Bioindicators KW - Alcohol KW - Age KW - blood pressure KW - cholesterol KW - police KW - Gender KW - law enforcement KW - Cardiovascular diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817611223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; Alcohol; Age; police; blood pressure; Gender; law enforcement; Cardiovascular diseases; cholesterol DO - http://dx.doi.org/10.1097/JOM.0b013e3181f4385c ER - TY - JOUR T1 - Dissolution of cemented carbide powders in artificial sweat: implications for cobalt sensitization and contact dermatitis AN - 817610732; 13981733 AB - Skin exposure to cobalt-containing materials can cause systemic immune sensitization and upon repeat contact, elicitation of allergic contact dermatitis (ACD). Data on cobalt dissolution rates are needed to calculate uptake through skin and for development of models to understand risk of sensitization or dermatitis. The purpose of this research was to measure the dissolution kinetics of feedstock and process-sampled powders encountered in the production of hard metal alloys using artificial sweat. The physicochemical properties of each material were characterized prior to evaluation of dissolution behavior. Variations in artificial sweat solvent pH and chemistry were used to understand critical factors in dissolution. Dissolution of cobalt, tungsten, and tungsten carbide was often biphasic with the initial rapid phase being up to three orders of magnitude faster than the latter long-term phase. Artificial sweat pH did not influence dissolution of cobalt or tungsten carbide. Solvent composition had little influence on observed dissolution rates; however, vitamin E suppressed the dissolution of cobalt and tungsten carbide from sintered particles obtained from a chamfer grinder. There was no effect of particle size on dissolution of feedstock cobalt, tungsten, tungsten carbide, and admixture powders. Particle physicochemical properties influenced observed dissolution rates with more cobalt and tungsten carbide dissolving from chamfer grinder particles compared to the feedstock powders or admixture powder. Calculations using the observed dissolution rates revealed that skin exposure concentrations were similar to concentrations known to induce cobalt sensitization and elicit ACD. Observed dissolution rates for cobalt in artificial sweat indicate that dermal uptake may be sufficient to induce cobalt sensitization and allergic dermatitis. JF - Journal of Environmental Monitoring AU - Stefaniak, AB AU - Harvey, C J AU - Virji, MA AU - Day, G A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2800, Morgantown, WV, 26505, USA, AStefaniak@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1815 EP - 1822 VL - 12 IS - 10 SN - 1464-0325, 1464-0325 KW - Risk Abstracts; Environment Abstracts; Pollution Abstracts KW - Metals KW - Skin KW - Contact dermatitis KW - Cobalt KW - contact dermatitis KW - Physicochemical properties KW - Solvents KW - Particulates KW - pH KW - Tungsten KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817610732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Dissolution+of+cemented+carbide+powders+in+artificial+sweat%3A+implications+for+cobalt+sensitization+and+contact+dermatitis&rft.au=Stefaniak%2C+AB%3BHarvey%2C+C+J%3BVirji%2C+MA%3BDay%2C+G+A&rft.aulast=Stefaniak&rft.aufirst=AB&rft.date=2010-10-01&rft.volume=12&rft.issue=10&rft.spage=1815&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc0em00269k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Metals; Contact dermatitis; Skin; contact dermatitis; Cobalt; Physicochemical properties; Solvents; Particulates; pH; Tungsten DO - http://dx.doi.org/10.1039/c0em00269k ER - TY - JOUR T1 - Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities AN - 815538440; 13869019 AB - Bioterrorism poses a daunting challenge to global security and public health in the 21st century. Variola major virus, the etiological agent of smallpox, and Bacillus anthracis, the bacterial pathogen responsible for anthrax, remain at the apex of potential pathogens that could be used in a bioterror attack to inflict mass casualties. Although licensed vaccines are available for both smallpox and anthrax, because of inadequacies associated with each of these vaccines, serious concerns remain as to the deployability of these vaccines, especially in the aftermath of a bioterror attack involving these pathogens. We have developed a single vaccine (Wyeth/IL-15/PA) using the licensed Wyeth smallpox vaccine strain that is efficacious against both smallpox and anthrax due to the integration of immune-enhancing cytokine IL-15 and the protective antigen (PA) of B. anthracis into the Wyeth vaccinia virus. Integration of IL-15 renders Wyeth vaccinia avirulent in immunodeficient mice and enhances anti-vaccinia immune responses. Wyeth/IL-15/PA conferred sterile protection against a lethal challenge of B. anthracis Ames strain spores in rabbits. A single dose of Wyeth/IL-15/PA protected 33% of the vaccinated A/J mice against a lethal spore challenge 72 h later whereas a single dose of licensed anthrax vaccine protected only 10%. Our dual vaccine Wyeth/IL-15/PA remedies the inadequacies associated with the licensed vaccines, and the inherent ability of Wyeth vaccinia virus to be lyophilized without loss of potency makes it cold-chain independent, thus simplifying the logistics of storage, stockpiling, and field delivery in the event of a bioterror attack involving smallpox or anthrax. JF - Proceedings of the National Academy of Sciences, USA AU - Merkel, Tod J AU - Perera, Pin-Yu AU - Kelly, Vanessa K AU - Verma, Anita AU - Llewellyn, Zara N AU - Waldmann, Thomas A AU - Mosca, Joseph D AU - Perera, Liyanage P AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 18091 EP - 18096 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 42 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Anthrax KW - Immune response KW - Immunodeficiency KW - Integration KW - Interleukin 15 KW - Pathogens KW - Public health KW - Smallpox KW - Spores KW - Vaccines KW - Vaccinia KW - bioterrorism KW - protective antigen KW - Bacillus anthracis KW - Vaccinia virus KW - Variola KW - F 06905:Vaccines KW - V 22350:Immunology KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815538440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Development+of+a+highly+efficacious+vaccinia-based+dual+vaccine+against+smallpox+and+anthrax%2C+two+important+bioterror+entities&rft.au=Merkel%2C+Tod+J%3BPerera%2C+Pin-Yu%3BKelly%2C+Vanessa+K%3BVerma%2C+Anita%3BLlewellyn%2C+Zara+N%3BWaldmann%2C+Thomas+A%3BMosca%2C+Joseph+D%3BPerera%2C+Liyanage+P&rft.aulast=Merkel&rft.aufirst=Tod&rft.date=2010-10-01&rft.volume=107&rft.issue=42&rft.spage=18091&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1013083107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - bioterrorism; Vaccinia; protective antigen; Immunodeficiency; Pathogens; Public health; Smallpox; Integration; Interleukin 15; Anthrax; Vaccines; Immune response; Spores; Vaccinia virus; Variola; Bacillus anthracis DO - http://dx.doi.org/10.1073/pnas.1013083107 ER - TY - JOUR T1 - Development of Human-Murine Chimeric Immunoglobulin G for Use in the Serological Detection of Human Flavivirus and Alphavirus Antibodies AN - 815536601; 13810841 AB - Diagnosis of human arboviral infections relies heavily on serological techniques such as the immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) and the indirect IgG ELISA. Broad application of these assays is hindered by the lack of standardized positive human control sera that react with a wide variety of flaviviruses (e.g., dengue, West Nile, yellow fever, Japanese encephalitis, Saint Louis encephalitis, and Powassan viruses), or alphaviruses (e.g., Eastern equine encephalitis, Western equine encephalitis, Venezuelan equine encephalitis, and chikungunya viruses) that can cause human disease. We have created human-murine chimeric monoclonal antibodies (cMAbs) by combining the variable regions of flavivirus (6B6C-1) or alphavirus (1A4B-6) broadly cross-reactive murine MAbs (mMAbs) with the constant region of human IgG1. These cMAbs may be used as standardized reagents capable of replacing human infection-immune-positive control sera in indirect IgG ELISA for diagnosis of all human flaviviral or alphaviral infections. The IgG cMAbs secreted from plasmid-transformed Sp2/0-Ag14 cells had serological activity identical to that of the parent mMAbs, as measured by ELISA using multiple flaviviruses or alphaviruses. JF - Clinical and Vaccine Immunology AU - Thibodeaux, Brett A AU - Panella, Amanda N AU - Roehrig, John T AD - Arboviral Diseases Branch, Division of Vector-Borne Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 3150 Rampart Road, Fort Collins, Colorado 80521, epx1@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1617 EP - 1623 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 10 SN - 1556-6811, 1556-6811 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Immunology Abstracts KW - Human diseases KW - Viruses KW - Disease control KW - Infection KW - Flavivirus KW - Public health KW - Constant region KW - Dengue KW - Senegal, Saint Louis KW - Yellow fever KW - ELISA KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Immunology KW - Venezuelan equine encephalitis KW - Encephalitis KW - Western equine encephalitis KW - Antibodies KW - Immunoglobulin G KW - Eastern equine encephalitis KW - Alphavirus KW - Vaccines KW - Immunoglobulin M KW - Variable region KW - F 06905:Vaccines KW - V 22300:Methods KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815536601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+of+Human-Murine+Chimeric+Immunoglobulin+G+for+Use+in+the+Serological+Detection+of+Human+Flavivirus+and+Alphavirus+Antibodies&rft.au=Thibodeaux%2C+Brett+A%3BPanella%2C+Amanda+N%3BRoehrig%2C+John+T&rft.aulast=Thibodeaux&rft.aufirst=Brett&rft.date=2010-10-01&rft.volume=17&rft.issue=10&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00097-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 33 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Human diseases; Antibodies; Monoclonal antibodies; Immunology; Viruses; Disease control; ELISA; Vaccines; Public health; Enzyme-linked immunosorbent assay; Venezuelan equine encephalitis; Infection; Encephalitis; Western equine encephalitis; Constant region; Dengue; Yellow fever; Immunoglobulin G; Eastern equine encephalitis; Immunoglobulin M; Variable region; Alphavirus; Flavivirus; Senegal, Saint Louis DO - http://dx.doi.org/10.1128/CVI.00097-10 ER - TY - JOUR T1 - Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid AN - 787260469; 13680778 AB - We evaluated renal melamine-cyanurate crystal spherulite formation after single and repeated ingestion of both melamine (MEL) and cyanuric acid (CYA) in catfish and trout. MEL and CYA were co-administered orally over a range of doses, 0.1-20mg/kg body weight (bw) of each compound, either once or repeatedly for 4, 14 or 28days (d). In catfish, the No Observable Adverse Effects Levels (NOAELs) for crystal formation for single, 4d or 14d dosing were 10, 2.5 and 0.5mg/kgbw, respectively. In trout, the respective NOAELs were 2.5, 2.5 and 0.5mg/kgbw. No renal crystals formed in catfish fed 0.1mg/kgbw of each compound for 28d. Sequential administration of 20mg/kgbw of MEL followed by 20mg/kgbw of CYA or vise-versa, with waiting periods of 1, 3, 7, 14 or 21d between compound dosing also induced renal crystal formation in fish. These studies show that both catfish and trout are sensitive, non-mammalian models, for renal crystal formation following MEL and CYA ingestion. Since fish generally excrete chemicals more slowly than mammals, they may provide a "worst case scenario" model for higher risk populations, such as infants or persons with compromised renal function. JF - Food and Chemical Toxicology AU - Reimschuessel, R AU - Evans, E R AU - Stine, C B AU - Hasbrouck, N AU - Mayer, T D AU - Nochetto, C AU - Gieseker, C M AD - Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd., Laurel, MD 20708, USA, Renate.reimschuessel@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2898 EP - 2906 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 48 IS - 10 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Bw KW - C KW - cm KW - CVM KW - CYA KW - d KW - DO KW - g KW - GLP KW - K el KW - L KW - LC-MS/MS KW - LOQ KW - MEL KW - mg/kg KW - min KW - mL KW - mM KW - N KW - NOAEL KW - ppm KW - s KW - S.D KW - t 1/2 KW - TDI KW - USFDA KW - VOCs KW - I14g/mL KW - I14m KW - Melamine KW - Cyanuric acid KW - Kidney KW - Crystal KW - No observable adverse effect level KW - Fish KW - Renal function KW - Body weight KW - Risk factors KW - spherulites KW - Oral administration KW - Crystals KW - Side effects KW - Models KW - Infants KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787260469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Renal+crystal+formation+after+combined+or+sequential+oral+administration+of+melamine+and+cyanuric+acid&rft.au=Reimschuessel%2C+R%3BEvans%2C+E+R%3BStine%2C+C+B%3BHasbrouck%2C+N%3BMayer%2C+T+D%3BNochetto%2C+C%3BGieseker%2C+C+M&rft.aulast=Reimschuessel&rft.aufirst=R&rft.date=2010-10-01&rft.volume=48&rft.issue=10&rft.spage=2898&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2010.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Body weight; Renal function; Risk factors; spherulites; Oral administration; Cyanuric acid; Crystals; Side effects; Infants; Models DO - http://dx.doi.org/10.1016/j.fct.2010.07.024 ER - TY - JOUR T1 - Categorizing Temporal Patterns of Arrest in a Cohort of Adults with Serious Mental Illness AN - 772256251; 201029978 AB - Temporal patterns of arrest among mental health systems' clientele have not been well explored. This study uses "trajectory analysis," a methodology widely employed by criminologists exploring patterns of desistence in offending, to examine patterns of criminal justice involvement in a cohort of mental health service recipients. Data for this study are from a statewide cohort of individuals who received services from the Massachusetts Department of Mental Health in 1991 (N?=?13,876) and whose arrests were followed for roughly 10 years. Zero-inflated Poisson trajectory analysis applied to cohort members having two or more arrests identified five trajectories with widely varying arrest patterns. Analysis of differences in the composition of the five trajectory-based groups revealed few between-group differences in members' demographic and service use characteristics, while certain offense types were disproportionately prevalent among particular trajectory-based groups. The implications of these findings for understanding criminal justice involvement in this population and the utility of the trajectory model for system planning are discussed. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Fisher, William H AU - Banks, Steven M AU - Roy-Bujnowski, Kristen AU - Grudzinskas, Albert J AU - Simon, Lorna J AU - Wolff, Nancy AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 bill.fisher@umassmed.edu Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 477 EP - 490 PB - Springer, US VL - 37 IS - 4 SN - 1094-3412, 1094-3412 KW - criminal justice involvement serious mental illness trajectory analysis KW - Mentally ill people KW - Criminal justice KW - Temporal patterns KW - Mental health KW - Arrests KW - Demographic aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772256251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Partition+coefficients+for+nonane+and+its+isomers+in+the+rat&rft.au=Joshi%2C+G%3BTremblay%2C+R+T%3BMartin%2C+SA%3BFisher%2C+J+W&rft.aulast=Joshi&rft.aufirst=G&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518175 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Arrests; Criminal justice; Mental health; Temporal patterns; Mentally ill people; Demographic aspects DO - http://dx.doi.org/10.1007/s11414-009-9188-9 ER - TY - JOUR T1 - Detection of Target Staphylococcal Enterotoxin B Antigen in Orange Juice and Popular Carbonated Beverages Using Antibody-Dependent Antigen-Capture Assays AN - 762271853; 13817336 AB - Abstract: There is a critical need for qualitative and quantitative methodologies that provide the rapid and accurate detection of food contaminants in complex food matrices. However, the sensitivity of the assay can be affected when antigen-capture is applied to certain foods or beverages that are extremely acidic. This study was undertaken to assess the effects of orange juice and popular carbonated soft drink upon the fidelity of antibody-based antigen-capture assays and to develop simple approaches that could rescue assay performance without the introduction of additional or extensive extraction procedures. We examined the effects of orange juice and a variety of popular carbonated soft drink beverages upon a quantitative Interleukin-2 (IL-2) enzyme-linked immunosorbent assay (ELISA) assay system and a lateral flow device (LFD) adapted for the detection of staphylococcal enterotoxin B (SEB) in foods. Alterations in the performance and sensitivity of the assay were directly attributable to the food matrix, and alterations in pH were especially critical. The results demonstrate that approaches such as an alteration of pH and the use of milk as a blocking agent, either singly or in combination, will partially rescue ELISA performance. The same approaches permit lateral flow to efficiently detect antigen. Practical Application: The authors present ways to rescue an ELISA assay compromised by acidity in beverages and show that either the alteration of pH, or the use of milk as a blocking agent are not always capable of restoring the assay to its intended efficiency. However, the same methods, when employed with lateral flow technology, are rapid and extremely successful. JF - Journal of Food Science AU - Principato, MaryAnn AU - Njoroge, Joyce M AU - Perlloni, Andrei AU - Donnell, Michael O' AU - Boyle, Thomas AU - Jones, Jr Robert L AD - 1Authors Principato, Njoroge, and Jones, Jr. are with the U.S. Food and Drug Administration, CFSAN 8301 Muirkirk Rd., Laurel, MD 20708, U.S.A. Author O'uDonnell is with U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20708, U.S.A. Author Perlloni is with U.S. Food and Drug Administration, Office Emergency Operations 5600 Fishers Lane, Rockville, Md. 20857, U.S.A. Previous address of authors Perlloni and Boyle is 8301 Muirkirk Rd., Laurel, MD, U.S.A. Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - T141 EP - T147 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 75 IS - 8 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - carbonated beverages KW - ELISA KW - lateral flow detector KW - orange juice KW - SEB KW - Citrus KW - Sensitivity KW - Enzyme-linked immunosorbent assay KW - Beverages KW - Milk KW - Interleukin 2 KW - Assays KW - Carbonated beverages KW - Food contamination KW - Staphylococcal enterotoxin B KW - Fruit juices KW - Fidelity KW - Immunoassays KW - pH effects KW - pH KW - J 02330:Biochemistry KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762271853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Detection+of+Target+Staphylococcal+Enterotoxin+B+Antigen+in+Orange+Juice+and+Popular+Carbonated+Beverages+Using+Antibody-Dependent+Antigen-Capture+Assays&rft.au=Principato%2C+MaryAnn%3BNjoroge%2C+Joyce+M%3BPerlloni%2C+Andrei%3BDonnell%2C+Michael+O%27%3BBoyle%2C+Thomas%3BJones%2C+Jr+Robert+L&rft.aulast=Principato&rft.aufirst=MaryAnn&rft.date=2010-10-01&rft.volume=75&rft.issue=8&rft.spage=T141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2010.01806.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 27 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Fruit juices; Fidelity; Enzyme-linked immunosorbent assay; Milk; Beverages; Interleukin 2; Carbonated beverages; Staphylococcal enterotoxin B; Food contamination; pH effects; Sensitivity; Assays; Immunoassays; pH; Citrus DO - http://dx.doi.org/10.1111/j.1750-3841.2010.01806.x ER - TY - JOUR T1 - Understanding Community Policing as an Innovation: Patterns of Adoption AN - 758129821; 201059603 AB - In the 1980s and 1990s, community policing was viewed by many as a radical innovation in the field of policing, with the vast majority of police agencies reporting to have adopted the approach. Despite its overwhelming popularity, most police agencies did not adopt the central elements of community policing. This study examines patterns of community policing adoption of 474 police departments across the United States. Using an innovations framework, a model was developed that measures the extent to which community characteristics, organizational complexity, and organizational commitment can explain differences in the adoption of community policing. Findings suggest that the innovations approach can explain some variation in the adoption of community policing and should be considered in future police research. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Crime & Delinquency AU - Schaefer Morabito, Melissa AD - Center for Mental Health Services & Criminal Justice Research New Brunswick, New Jersey Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 564 EP - 587 PB - Sage Publications, Thousand Oaks CA VL - 56 IS - 4 SN - 0011-1287, 0011-1287 KW - community policing innovations adoption KW - Socioeconomic Factors KW - Organizational Commitment KW - Methodology (Data Collection) KW - Investigations (Law Enforcement) KW - United States of America KW - Police KW - Adoption of Innovations KW - Innovations KW - article KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758129821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Crime+%26+Delinquency&rft.atitle=Understanding+Community+Policing+as+an+Innovation%3A+Patterns+of+Adoption&rft.au=Schaefer+Morabito%2C+Melissa&rft.aulast=Schaefer+Morabito&rft.aufirst=Melissa&rft.date=2010-10-01&rft.volume=56&rft.issue=4&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Crime+%26+Delinquency&rft.issn=00111287&rft_id=info:doi/10.1177%2F0011128707311643 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 49 N1 - Last updated - 2016-09-28 N1 - CODEN - CRDLAL N1 - SubjectsTermNotLitGenreText - Investigations (Law Enforcement); Police; Adoption of Innovations; Innovations; United States of America; Methodology (Data Collection); Organizational Commitment; Socioeconomic Factors DO - http://dx.doi.org/10.1177/0011128707311643 ER - TY - JOUR T1 - Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics. AN - 756298596; 20882612 AB - To examine preprocessing methods affecting the potential use of Magnetic Resonance Spectroscopy (MRS) as a noninvasive modality for detection and characterization of brain lesions and for directing therapy progress. Two reference point re-calibration with linear interpolation (to compensate for magnetic field nonhomogeneity), weighting of spectra (to emphasize consistent peaks and depress chemical noise), and modeling based on chemical shift locations of 97 biomarkers were investigated. Results for 139 categorized scans were assessed by comparing Leave-One-Out (LOO) cross-validation and external validation. For distinction of nine brain tissue categories, use of re-calibration, variance weighting, and biomarker modeling improved LOO classification of MRS spectra from 31% to 95%. External validation of the two best nine-category models on 47 unknown samples gave 96% or 100% accuracy, respectively, compared with pathological diagnosis. Preprocessing of MRS spectra can significantly improve their diagnostic utility for automated consultation of pattern recognition models. Use of several techniques in combination greatly increases available proton MRS information content. Accurate assignment of unknowns among nine tissue classes represents a significant improvement, for a much more demanding task, than has been previously reported. JF - Journal of magnetic resonance imaging : JMRI AU - Alusta, Pierre AU - Im, Inessa AU - Pearce, Bruce A AU - Beger, Richard D AU - Kretzer, Ryan M AU - Buzatu, Dan A AU - Wilkes, Jon G AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas 72079, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 818 EP - 829 VL - 32 IS - 4 KW - Biomarkers KW - 0 KW - Protons KW - Index Medicus KW - Biomarkers -- chemistry KW - Brain Mapping -- methods KW - Reproducibility of Results KW - Humans KW - Brain -- pathology KW - Calibration KW - Automatic Data Processing KW - Pattern Recognition, Automated KW - Image Processing, Computer-Assisted KW - Brain Neoplasms -- pathology KW - Magnetic Resonance Spectroscopy -- methods KW - Medical Oncology -- methods KW - Brain Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756298596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.atitle=Improving+proton+MR+spectroscopy+of+brain+tissue+for+noninvasive+diagnostics.&rft.au=Alusta%2C+Pierre%3BIm%2C+Inessa%3BPearce%2C+Bruce+A%3BBeger%2C+Richard+D%3BKretzer%2C+Ryan+M%3BBuzatu%2C+Dan+A%3BWilkes%2C+Jon+G&rft.aulast=Alusta&rft.aufirst=Pierre&rft.date=2010-10-01&rft.volume=32&rft.issue=4&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.issn=1522-2586&rft_id=info:doi/10.1002%2Fjmri.22332 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-02 N1 - Date created - 2010-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jmri.22332 ER - TY - JOUR T1 - Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. AN - 755970637; 20548288 AB - The importance of dysregulation of microRNA (miRNA) expression in nonalcoholic steatohepatitis (NASH) has been increasingly recognized; however, the association between altered expression of miRNAs and pathophysiological features of NASH and whether there is a connection between susceptibility to NASH and altered expression of miRNAs are largely unknown. In this study, male inbred C57BL/6J and DBA/2J mice were fed a lipogenic methyl-deficient diet that causes liver injury similar to human NASH, and the expression of miRNAs and the level of proteins targeted by these miRNAs in the livers were determined. Administration of the methyl-deficient diet triggered NASH-specific changes in the livers of C57BL/6J and DBA/2J mice, with the magnitude being more severe in DBA/2J mice. This was evidenced by a greater extent of expression of fibrosis-related genes in the livers of methyl-deficient DBA/2J mice. The development of NASH was accompanied by prominent changes in the expression of miRNAs, including miR-29c, miR-34a, miR-155, and miR-200b. Interestingly, changes in the expression of these miRNAs and protein levels of their targets, including Cebp-β, Socs 1, Zeb-1, and E-cadherin, in the livers of DBA/2J mice fed a methyl-deficient diet were more pronounced as compared with those in C57BL/6J mice. These results show that alterations in the expression of miRNAs are a prominent event during development of NASH induced by methyl deficiency and strongly suggest that severity of NASH and susceptibility to NASH may be determined by variations in miRNA expression response. More important, our data provide a mechanistic link between alterations in miRNA expression and pathophysiological and pathomorphological features of NASH. JF - Laboratory investigation; a journal of technical methods and pathology AU - Pogribny, Igor P AU - Starlard-Davenport, Athena AU - Tryndyak, Volodymyr P AU - Han, Tao AU - Ross, Sharon A AU - Rusyn, Ivan AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1437 EP - 1446 VL - 90 IS - 10 KW - MIRN29 microRNA, mouse KW - 0 KW - MicroRNAs KW - Mirn134 microRNA, mouse KW - Mirn155 microRNA, mouse KW - Mirn200 microRNA, mouse KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Gene Expression Regulation KW - Chronic Disease KW - Diet KW - Lipogenesis KW - Species Specificity KW - Male KW - Mice, Inbred DBA KW - Liver -- pathology KW - Fatty Liver -- chemically induced KW - Disease Susceptibility KW - MicroRNAs -- genetics KW - MicroRNAs -- biosynthesis KW - Liver -- metabolism KW - Fatty Liver -- genetics KW - Fatty Liver -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755970637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Difference+in+expression+of+hepatic+microRNAs+miR-29c%2C+miR-34a%2C+miR-155%2C+and+miR-200b+is+associated+with+strain-specific+susceptibility+to+dietary+nonalcoholic+steatohepatitis+in+mice.&rft.au=Pogribny%2C+Igor+P%3BStarlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BRoss%2C+Sharon+A%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-01&rft.volume=90&rft.issue=10&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2010.113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/labinvest.2010.113 ER - TY - JOUR T1 - Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens. AN - 755159680; 20661548 AB - The aim of this study was to determine the incidence of tetracycline resistance and the prevalence of tetracycline-resistance genes in strains of Clostridium perfringens isolated from different sources between 1994 and 2005. Susceptibility to tetracycline and minocycline in strains from humans (35 isolates), chickens (15 isolates), food (21 isolates), soil (16 isolates) and veterinary sources (6 isolates) was determined, and tetracycline-resistance genes were detected. Resistance was most common in strains isolated from chickens, followed by those from soils, clinical samples and foods. The most highly resistant strains were found among clinical and food isolates. tetA(P) was the most common resistance gene, and along with tetB(P) was found in all resistant strains and some sensitive strains. One tetracycline-resistant food isolate had an intact tet(M) gene. However, PCR fragments of 0.4 or 0.8 kb with high degrees of identity to parts of the tet(M) sequences of other bacteria were found, mainly in clinical isolates, and often in isolates with tetB(P). No correlation between level of sensitivity to tetracycline or minocycline and the presence of tetA(P), tetB(P) or part of tet(M) was found. The presence of part of tet(M) in some strains of C. perfringens containing tetB(P) may have occurred by recent gene transfer. JF - Archives of microbiology AU - Park, Miseon AU - Rooney, Alejandro P AU - Hecht, David W AU - Li, Jihong AU - McClane, Bruce A AU - Nayak, Rajesh AU - Paine, Donald D AU - Rafii, Fatemeh AD - National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 803 EP - 810 VL - 192 IS - 10 KW - Anti-Bacterial Agents KW - 0 KW - Antiporters KW - Bacterial Proteins KW - TETP protein, Clostridium perfringens KW - tetA protein, Bacteria KW - Tetracycline KW - F8VB5M810T KW - Minocycline KW - FYY3R43WGO KW - Index Medicus KW - Animals KW - Genes, Bacterial KW - Bacterial Proteins -- genetics KW - Humans KW - Antiporters -- genetics KW - Microbial Sensitivity Tests KW - Tetracycline Resistance -- genetics KW - Minocycline -- pharmacology KW - Clostridium perfringens -- genetics KW - Clostridium perfringens -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Tetracycline -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755159680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Phenotypic+and+genotypic+characterization+of+tetracycline+and+minocycline+resistance+in+Clostridium+perfringens.&rft.au=Park%2C+Miseon%3BRooney%2C+Alejandro+P%3BHecht%2C+David+W%3BLi%2C+Jihong%3BMcClane%2C+Bruce+A%3BNayak%2C+Rajesh%3BPaine%2C+Donald+D%3BRafii%2C+Fatemeh&rft.aulast=Park&rft.aufirst=Miseon&rft.date=2010-10-01&rft.volume=192&rft.issue=10&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=1432-072X&rft_id=info:doi/10.1007%2Fs00203-010-0605-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-30 N1 - Date created - 2010-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00203-010-0605-5 ER - TY - JOUR T1 - Oncomutations as biomarkers of cancer risk AN - 1034809974; 15033743 AB - Cancer risk assessment impacts a range of societal needs, from the regulation of chemicals to achieving the best possible human health outcomes. Because oncogene and tumor suppressor gene mutations are necessary for the development of cancer, such mutations are ideal biomarkers to use in cancer risk assessment. Consequently, DNA-based methods to quantify particular tumor-associated hotspot point mutations (i.e., oncomutations) have been developed, including allele-specific competitive blocker-PCR (ACB-PCR). Several studies using ACB-PCR and model mutagens have demonstrated that significant induction of tumor-associated oncomutations are measureable at earlier time points than are used to score tumors in a bioassay. In the particular case of benzo[a]pyrene induction of K-Ras codon 12 TGT mutation in the A/J mouse lung, measurement of tumor-associated oncomutation was shown to be an earlier and more sensitive endpoint than tumor response. The measurement of oncomutation by ACB-PCR led to two unexpected findings. First, oncomutations are present in various tissues of control rodents and 'normal' human colonic mucosa samples at relatively high frequencies. Approximately 60% of such samples (88/146) have mutant fractions (MFs) >10-5, and some have MFs as high as 10-3 or 10-4. Second, preliminary data indicate that oncomutations are present frequently as subpopulations in tumors. These findings are integrated into a hypothesis that the predominant preexisting mutations in particular tissues may be useful as generic reporters of carcinogenesis. Future research opportunities using oncomutation as an endpoint are described, including rodent to human extrapolation, dose-response assessment, and personalized medicine. Environ. Mol. Mutagen., 2010. Published 2010 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Parsons, Barbara L AU - Myers, Meagan B AU - Meng, Fanxue AU - Wang, Yiying AU - McKinzie, Page B Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 836 EP - 850 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 8-9 SN - 0893-6692, 0893-6692 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Risk assessment KW - Chemicals KW - Mutagens KW - Hot spots KW - Tumors KW - Mutation KW - Cancer KW - Rodents KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034809974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Oncomutations+as+biomarkers+of+cancer+risk&rft.au=Parsons%2C+Barbara+L%3BMyers%2C+Meagan+B%3BMeng%2C+Fanxue%3BWang%2C+Yiying%3BMcKinzie%2C+Page+B&rft.aulast=Parsons&rft.aufirst=Barbara&rft.date=2010-10-01&rft.volume=51&rft.issue=8-9&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20600 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20600/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Chemicals; Risk assessment; Bioindicators; Mutagens; Hot spots; Tumors; Mutation; Rodents; Cancer DO - http://dx.doi.org/10.1002/em.20600 ER - TY - JOUR T1 - Improving the quality of industry and occupation data at a central cancer registry AN - 1017967097; 16691627 AB - Background Central cancer registries are required to collect industry and occupation (I/O) information when available, but the data reported are often incomplete. Methods We audited the completeness of I/O data in the New Hampshire State Cancer Registry (NHSCR) database for diagnosis year 2005, and reviewed medical records for a convenience sample of 474 of these cases. We compared I/O data quality before and after a statewide registrar training session on occupationally related cancers. Results The original 2005 data contained both I/O data in 11.5% of cases, and lacked any I/O data in 74.5%. Corresponding figures for cases selected for audit were 15.2% and 77.2%, which improved to 54.2% and 11.8% after medical record review. After registrar training, 47% of reports contained both I/O data, and only 14.4% of cases lacked any I/O data. Conclusions Statewide training to highlight the importance of I/O data is an effective method to improve I/O data quality. Am. J. Ind. Med. 53:995-1001, 2010. ? 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Armenti, Karla R AU - Celaya, Maria O AU - Cherala, Sai AU - Riddle, Bruce AU - Schumacher, Pamela K AU - Rees, Judy R AD - New Hampshire Department of Health and Human Services, Division of Public Health Services, Office of Health Statistics and Data Management, Concord, New Hampshire, karmenti@dhhs.state.nh.us Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 995 EP - 1001 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 10 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Training KW - Reviews KW - USA, New Hampshire KW - Cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017967097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Improving+the+quality+of+industry+and+occupation+data+at+a+central+cancer+registry&rft.au=Armenti%2C+Karla+R%3BCelaya%2C+Maria+O%3BCherala%2C+Sai%3BRiddle%2C+Bruce%3BSchumacher%2C+Pamela+K%3BRees%2C+Judy+R&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2010-10-01&rft.volume=53&rft.issue=10&rft.spage=995&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20851 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20851/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Training; Reviews; Cancer; USA, New Hampshire DO - http://dx.doi.org/10.1002/ajim.20851 ER - TY - JOUR T1 - Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy AN - 762280038; 13762424 AB - Background:It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC. Methods:Using population-based data, we calculated BC risk following HL according to clinicopathologic features. Results:Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC. Conclusion:Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors. JF - British Journal of Cancer AU - Dores, G M AU - Anderson, W F AU - Beane Freeman, L E AU - Fraumeni, J F AU - Curtis, R E AD - [1] Medical Service, Department of Veterans Affairs Medical Center, 921 N.E. 13th Street, Oklahoma City, OK 73104, USA [2] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Bethesda, MD 20892, USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 1081 EP - 1084 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 7 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - Risk assessment KW - Progesterone receptors KW - Hodgkin's disease KW - Data processing KW - Radiotherapy KW - Breast cancer KW - lymphoma KW - radiotherapy KW - Estrogen receptors KW - Cancer KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762280038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+breast+cancer+according+to+clinicopathologic+features+among+long-term+survivors+of+Hodgkin%27s+lymphoma+treated+with+radiotherapy&rft.au=Dores%2C+G+M%3BAnderson%2C+W+F%3BBeane+Freeman%2C+L+E%3BFraumeni%2C+J+F%3BCurtis%2C+R+E&rft.aulast=Dores&rft.aufirst=G&rft.date=2010-09-28&rft.volume=103&rft.issue=7&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605877 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Progesterone receptors; Data processing; Hodgkin's disease; Breast cancer; Radiotherapy; Estrogen receptors; radiotherapy; lymphoma; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605877 ER - TY - JOUR T1 - Kainic acid and 3-Nitropropionic acid induced expression of laminin in vascular elements of the rat brain. AN - 748971393; 20624377 AB - Laminin is a glycoprotein component of the basement membrane and has been reported to be found in different areas of the nervous system including brain endothelial cells, Schwann cells and peripheral nerves. Although the in-vitro studies suggest that laminin plays an important role in growth and neurite extension of cultured neurons, localization of laminin in the brain has been controversial and inconsistent results have been reported. Recently, laminin immunoreactivity has been used as a marker for vascular elements in the brain. In this study, we have investigated the effect of two mechanistically different neurotoxins, kainic acid (KA), an NMDA agonist and 3-Nitropropionic acid (3-NPA), an inhibitor of mitochondrial respiration, on brain vascular elements revealed by laminin immunolabeling. We also explored whether administration of these two neurotoxic drugs correlate with the neuronal degeneration observed after neurotoxic insult by staining with Fluoro-Jade C dye. We have employed single immunolabeling to localize laminin in the brains. In KA treated rats, most of the laminin immunoreactivity is present in the piriform cortex, corpus callosum (myelinated tracts) amygdala, hippocampus, ventral thalamus and tenia tacta. In 3-NPA treated animals, laminin immunoreactivity was confined mostly to the striatum. In contrast, saline treated rats showed very little laminin immunolabeling around capillaries, arteries and in the meningeal membranes. To determine the effects of these neurotoxins on the integrity of the blood brain barrier (BBB), endothelial brain barrier antigen (EBA) immunolabeling was also performed. In addition, we performed CD11b immunolabeling to evaluate the effect of 3-NPA and KA on the activation of microglia in the brain. CD11b was dramatically increased in KA and 3-NPA treated animals. We have also combined laminin immunolabeling with Fluoro-Jade C labeling to evaluate the spatio-temporal association of degenerating neurons and the expression of laminin containing microvessels. Areas which showed intense laminin immunolabeling following KA or 3-NPA exposure correlated with those exhibiting the greatest number of degenerating neurons observed after Fluoro-Jade C staining. EBA-laminin double immunolabeling demonstrated that the expressions of laminin were predominantly localized in the areas (cortex, thalamus and hippocampus) where EBA has been either reduced or is absent. Our results from these experiments demonstrate that vascular laminin expression increases after treatment with KA or 3-NPA, suggesting the occurrence of neovascularization. Microglia may also contribute to the neurotoxic induced neovascularization and neurodegeneration. JF - Brain research AU - Sarkar, Sumit AU - Schmued, Larry AD - Division of Neurotoxicology, National Center for Toxicological Research (NCTR), Jefferson, AR 72079, USA. Y1 - 2010/09/17/ PY - 2010 DA - 2010 Sep 17 SP - 239 EP - 247 VL - 1352 KW - Antigens, CD11b KW - 0 KW - Laminin KW - Neurotoxins KW - Nitro Compounds KW - Propionates KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Laminin -- metabolism KW - Antigens, CD11b -- metabolism KW - Blood-Brain Barrier -- physiology KW - Neurotoxins -- pharmacology KW - Antigens, CD11b -- drug effects KW - Motor Activity -- physiology KW - Tremor -- chemically induced KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Behavior, Animal -- drug effects KW - Laminin -- drug effects KW - Gait -- physiology KW - Hypothermia -- chemically induced KW - Behavior, Animal -- physiology KW - Motor Activity -- drug effects KW - Gait -- drug effects KW - Immunohistochemistry KW - Kainic Acid -- pharmacology KW - Propionates -- pharmacology KW - Nitro Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748971393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Kainic+acid+and+3-Nitropropionic+acid+induced+expression+of+laminin+in+vascular+elements+of+the+rat+brain.&rft.au=Sarkar%2C+Sumit%3BSchmued%2C+Larry&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2010-09-17&rft.volume=1352&rft.issue=&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2010.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-22 N1 - Date created - 2010-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2010.07.011 ER - TY - JOUR T1 - ISA software suite: supporting standards-compliant experimental annotation and enabling curation at the community level AN - 818831388; 13719984 AB - SUMMARY: The first open source software suite for experimentalists and curators that (i) assists in the annotation and local management of experimental metadata from high-throughput studies employing one or a combination of omics and other technologies; (ii) empowers users to uptake community-defined checklists and ontologies; and (iii) facilitates submission to international public repositories. JF - Bioinformatics AU - Rocca-Serra, Philippe AU - Brandizi, Marco AU - Maguire, Eamonn AU - Sklyar, Nataliya AU - Taylor, Chris AU - Begley, Kimberly AU - Field, Dawn AU - Harris, Stephen AU - Hide, Winston AU - Hofmann, Oliver AU - Neumann, Steffen AU - Sterk, Peter AU - Tong, Weida AU - Sansone, Susanna-Assunta AD - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD and Oxford e-Research Centre, University of Oxford, 7 Keble Road, Oxford OX1 3QG, Natural Environment Research Council, Environmental Bioinformatics Centre, Wallingford CEH, Benson Lane, Mansfield Road, Oxford OX10 8BB, UK, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA, Genomic Standards Consortium, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK, US Food and Drug Administration, Center for Bioinformatics, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA and Leibniz Institute of Plant Biochemistry, Department of Stress and Developmental Biology, Weinberg 3, 06120 Halle, Germany Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 2354 EP - 2356 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 18 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Check lists KW - high-throughput screening KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818831388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=ISA+software+suite%3A+supporting+standards-compliant+experimental+annotation+and+enabling+curation+at+the+community+level&rft.au=Rocca-Serra%2C+Philippe%3BBrandizi%2C+Marco%3BMaguire%2C+Eamonn%3BSklyar%2C+Nataliya%3BTaylor%2C+Chris%3BBegley%2C+Kimberly%3BField%2C+Dawn%3BHarris%2C+Stephen%3BHide%2C+Winston%3BHofmann%2C+Oliver%3BNeumann%2C+Steffen%3BSterk%2C+Peter%3BTong%2C+Weida%3BSansone%2C+Susanna-Assunta&rft.aulast=Rocca-Serra&rft.aufirst=Philippe&rft.date=2010-09-15&rft.volume=26&rft.issue=18&rft.spage=2354&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Check lists; high-throughput screening; Bioinformatics ER - TY - JOUR T1 - Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study? AN - 1017962837; 16689052 AB - BACKGROUND: Meat could be involved in bladder carcinogenesis via multiple potentially carcinogenic meat-related compounds related to cooking and processing, including nitrate, nitrite, heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs). The authors comprehensively investigated the association between meat and meat components and bladder cancer. METHODS: During 7 years of follow-up, 854 transitional cell bladder-cancer cases were identified among 300,933 men and women who had completed a validated food-frequency questionnaire in the large prospective NIH-AARP Diet and Health Study. The authors estimated intake of nitrate and nitrite from processed meat and HCAs and PAHs from cooked meat by using quantitative databases of measured values. Total dietary nitrate and nitrite were calculated based on literature values. RESULTS: The hazard ratios (HR) and 95% confidence intervals (CI) for red meat (HR for fifth quintile compared with first quintile, 1.22; 95% CI, 0.96-1.54; Ptrend = .07) and the HCA 2-amino-1 methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) (HR, 1.19; 95% CI, 0.95-1.48; Ptrend = .06) conferred a borderline statistically significant increased risk of bladder cancer. Positive associations were observed in the top quintile for total dietary nitrite (HR, 1.28; 95% CI, 1.02-1.61; Ptrend = .06) and nitrate plus nitrite intake from processed meat (HR, 1.29; 95% CI, 1.00-1.67; Ptrend = .11). CONCLUSIONS: These findings provided modest support for an increased risk of bladder cancer with total dietary nitrite and nitrate plus nitrite from processed meat. Results also suggested a positive association between red meat and PhIP and bladder carcinogenesis. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Ferrucci, Leah M AU - Sinha, Rashmi AU - Ward, Mary H AU - Graubard, Barry I AU - Hollenbeck, Albert R AU - Kilfoy, Briseis A AU - Schatzkin, Arthur AU - Michaud, Dominique S AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, crossa@mail.nih.gov Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 4345 EP - 4353 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 18 SN - 1097-0142, 1097-0142 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Amines KW - Cancer KW - Carcinogenesis KW - Carcinogenicity KW - Diets KW - Meat KW - Nitrates KW - Nitrites KW - Urinary bladder KW - cooking KW - meat KW - urinary bladder KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Meat+and+components+of+meat+and+the+risk+of+bladder+cancer+in+the+NIH-AARP+Diet+and+Health+Study%3F&rft.au=Ferrucci%2C+Leah+M%3BSinha%2C+Rashmi%3BWard%2C+Mary+H%3BGraubard%2C+Barry+I%3BHollenbeck%2C+Albert+R%3BKilfoy%2C+Briseis+A%3BSchatzkin%2C+Arthur%3BMichaud%2C+Dominique+S%3BCross%2C+Amanda+J&rft.aulast=Ferrucci&rft.aufirst=Leah&rft.date=2010-09-15&rft.volume=116&rft.issue=18&rft.spage=4345&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25463 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25463/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Meat; Diets; urinary bladder; Nitrates; Nitrites; Urinary bladder; Carcinogenicity; Carcinogenesis; meat; cooking; Amines; Cancer DO - http://dx.doi.org/10.1002/cncr.25463 ER - TY - JOUR T1 - Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium AN - 759316559; 13721190 AB - BACKGROUND: Previous studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, and duration of cigarette smoking cessation. METHODS: We used primary data from 10 population-based case-control studies and two cohort studies from the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Analyses were restricted to white non-Hispanic men and women. Patients were classified as having esophageal adenocarcinoma (n = 1540), esophagogastric junctional adenocarcinoma (n = 1450), or a combination of both (all adenocarcinoma; n = 2990). Control subjects (n = 9453) were population based. Associations between pack-years of cigarette smoking and risks of adenocarcinomas were assessed, as well as their potential modification by sex and duration of smoking cessation. Study-specific odds ratios (ORs) estimated using multivariable logistic regression models, adjusted for age, sex, body mass index, education, and gastroesophageal reflux, were pooled using a meta-analytic methodology to generate summary odds ratios. All statistical tests were two-sided. RESULTS: The summary odds ratios demonstrated strong associations between cigarette smoking and esophageal adenocarcinoma (OR = 1.96, 95% confidence interval [CI] = 1.64 to 2.34), esophagogastric junctional adenocarcinoma (OR = 2.18, 95% CI = 1.84 to 2.58), and all adenocarcinoma (OR = 2.08, 95% CI = 1.83 to 2.37). In addition, there was a strong dose-response association between pack-years of cigarette smoking and each outcome (P < .001). Compared with current smokers, longer smoking cessation was associated with a decreased risk of all adenocarcinoma after adjusting for pack-years (<10 years of smoking cessation: OR = 0.82, 95% CI = 0.60 to 1.13; and .10 years of smoking cessation: OR = 0.71, 95% CI = 0.56 to 0.89). Sex-specific summary odds ratios were similar. CONCLUSIONS: Cigarette smoking is associated with increased risks of adenocarcinomas of the esophagus and esophagogastric junction in white men and women; compared with current smoking, smoking cessation was associated with reduced risks. JF - Journal of the National Cancer Institute AU - Cook, Michael B AU - Kamangar, Farin AU - Whiteman, David C AU - Freedman, Neal D AU - Gammon, Marilie D AU - Bernstein, Leslie AU - Brown, Linda M AU - Risch, Harvey A AU - Ye, Weimin AU - Sharp, Linda AU - Pandeya, Nirmala AU - Webb, Penelope M AU - Wu, Anna H AU - Ward, Mary H AU - Giffen, Carol AU - Casson, Alan G AU - Abnet, Christian C AU - Murray, Liam J AU - Corley, Douglas A AU - Nyren, Olof AU - Vaughan, Thomas L AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (MBC, FK, NDF, MHW, CCA, W-HC) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1344 EP - 1353 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Age KW - Cigarettes KW - Statistical analysis KW - tumors KW - Models KW - risk reduction KW - Smoking KW - body mass KW - Dose-response effects KW - Cigarette smoking KW - Regression analysis KW - Drug addiction KW - Sex KW - Esophagus KW - Data processing KW - Barrett's esophagus KW - Tumors KW - Cancer KW - Education KW - Gastroesophageal reflux KW - Body mass index KW - Adenocarcinoma KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cigarette+Smoking+and+Adenocarcinomas+of+the+Esophagus+and+Esophagogastric+Junction%3A+A+Pooled+Analysis+From+the+International+BEACON+Consortium&rft.au=Cook%2C+Michael+B%3BKamangar%2C+Farin%3BWhiteman%2C+David+C%3BFreedman%2C+Neal+D%3BGammon%2C+Marilie+D%3BBernstein%2C+Leslie%3BBrown%2C+Linda+M%3BRisch%2C+Harvey+A%3BYe%2C+Weimin%3BSharp%2C+Linda%3BPandeya%2C+Nirmala%3BWebb%2C+Penelope+M%3BWu%2C+Anna+H%3BWard%2C+Mary+H%3BGiffen%2C+Carol%3BCasson%2C+Alan+G%3BAbnet%2C+Christian+C%3BMurray%2C+Liam+J%3BCorley%2C+Douglas+A%3BNyren%2C+Olof%3BVaughan%2C+Thomas+L%3BChow%2C+Wong-Ho&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Data processing; Barrett's esophagus; Statistical analysis; Tumors; Models; Smoking; Gastroesophageal reflux; Cigarette smoking; Regression analysis; Adenocarcinoma; Drug addiction; Body mass index; Sex; risk reduction; Age; Education; Cigarettes; body mass; Dose-response effects; tumors; Cancer ER - TY - JOUR T1 - Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort AN - 759316492; 13721189 AB - BACKGROUND: Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations. METHODS: We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided. RESULTS: We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 person-years). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 person-years). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome. CONCLUSION: Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk. JF - Journal of the National Cancer Institute AU - Freedman, Neal D AU - Cross, Amanda J AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Everhart, James E AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (NDF, AJC, KAM, CCA, YP, AS, RS) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1354 EP - 1365 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Heterocyclic amines KW - Nitrate KW - Heme KW - Statistical analysis KW - Models KW - Risk factors KW - meat KW - Regression analysis KW - Nitrite KW - Hepatocellular carcinoma KW - Diets KW - Mortality KW - Liver diseases KW - Nitrates KW - Amines KW - Cancer KW - Meat KW - N-Nitroso compounds KW - Nitrites KW - Liver KW - quinoxaline KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+Meat+and+Fat+Intake+With+Liver+Disease+and+Hepatocellular+Carcinoma+in+the+NIH-AARP+Cohort&rft.au=Freedman%2C+Neal+D%3BCross%2C+Amanda+J%3BMcGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BEverhart%2C+James+E%3BSinha%2C+Rashmi&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Nitrate; Heterocyclic amines; Mortality; Liver diseases; Heme; Statistical analysis; Models; Meat; N-Nitroso compounds; Risk factors; quinoxaline; Regression analysis; Nitrite; Iron; Hepatocellular carcinoma; Nitrates; Nitrites; meat; Liver; Amines; Cancer ER - TY - JOUR T1 - Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation AN - 1677990664; 14160336 AB - The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators. We investigated the molecular mechanisms underlying interleuken-10 (IL-10)-mediated attenuation of O3-induced pulmonary inflammation in mice. Il10-deficient (Il10-/-) and wild-type (Il10+/+) mice were exposed to 0.3 ppm O3 or filtered air for 24, 48, or 72 hr. Immediately after exposure, differential cell counts and total protein (a marker of lung permeability) were assessed from bronchoalveolar lavage fluid (BALF). mRNA and protein levels of cellular mediators were determined from lung homogenates. We also used global mRNA expression analyses of lung tissue with Ingenuity Pathway Analysis to identify patterns of gene expression through which IL-10 modifies O3-induced inflammation. Mean numbers of BALF polymorphonuclear leukocytes (PMNs) were significantly greater in Il10-/- mice than in Il10+/+ mice after exposure to O3 at all time points tested. O3-enhanced nuclear NF- Kappa B translocation was elevated in the lungs of Il10-/- compared with Il10+/+ mice. Gene expression analyses revealed several IL-10-dependent and O3-dependent mediators, including macrophage inflammatory protein 2, cathepsin E, and serum amyloid A3. Results indicate that IL-10 protects against O3-induced pulmonary neutrophilic inflammation and cell proliferation. Moreover, gene expression analyses identified three response pathways and several genetic targets through which IL-10 may modulate the innate and adaptive immune response. These novel mechanisms of protection against the pathogenesis of O3-induced pulmonary inflammation may also provide potential therapeutic targets to protect susceptible individuals. JF - Environmental Health Perspectives AU - Backus, Gillian S AU - Howden, Reuben AU - Fostel, Jennifer AU - Bauer, Alison K AU - Cho, Hye-Youn AU - Marzec, Jacqui AU - Peden, David B AU - Kleeberger, Steven R AD - National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1721 EP - 1727 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - air pollution KW - gene array KW - IL-10 KW - inflammation KW - lung KW - ozone KW - pulmonary KW - Gene expression KW - Cellular KW - Pathways KW - Protein A KW - Proteins KW - Lungs KW - Cytokines KW - Mice KW - Protective UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677990664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Protective+Role+of+Interleukin-10+in+Ozone-Induced+Pulmonary+Inflammation&rft.au=Backus%2C+Gillian+S%3BHowden%2C+Reuben%3BFostel%2C+Jennifer%3BBauer%2C+Alison+K%3BCho%2C+Hye-Youn%3BMarzec%2C+Jacqui%3BPeden%2C+David+B%3BKleeberger%2C+Steven+R&rft.aulast=Backus&rft.aufirst=Gillian&rft.date=2010-09-08&rft.volume=118&rft.issue=2&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002182 ER - TY - JOUR T1 - The Medical Reserve Corps as Part of the Federal Medical and Public Health Response in Disaster Settings AN - 1257782534; 17458521 AB - The Secretary of the Department of Health and Human Services (HHS), through the Office of the Assistant Secretary for Preparedness and Response (ASPR), coordinates federal Emergency Support Function (ESF) #8 preparedness, response, and recovery actions. To address these needs, the ASPR can draw on trained personnel from a variety of sources, both from within and outside HHS. Among the resources under the domain of HHS is the Medical Reserve Corps (MRC), directed by the Office of the Civilian Volunteer Medical Reserve Corps (OCVMRC) in the Office of the Surgeon General. MRC units are community based and function as a way to locally organize and utilize medical and public health professionals, such as physicians, nurses, pharmacists, dentists, veterinarians, and epidemiologists. Nonclinical volunteers, such as interpreters, chaplains, office workers, legal advisors, and others, can fill logistical and support roles in MRC units. This article discusses locally controlled (Hurricanes Gustav and Ike) and federalized (Hurricanes Katrina and Rita) MRC activations, and it describes the advantages of using medical volunteers in a large-scale disaster response setting. JF - Biosecurity and Bioterrorism AU - Frasca AD - Office of Emergency Operations, Office of Crisis Management, Food and Drug Administration, Room 12A55 Parklawn, 5600 Fishers Lane, Rockville, MD 20852, USA, dominic.frasca@fda.hhs.gov Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 265 EP - 271 VL - 8 IS - 3 SN - 1538-7135, 1538-7135 KW - Health & Safety Science Abstracts KW - Community involvement KW - Dentistry KW - Disasters KW - Hurricanes KW - Medical personnel KW - Nursing KW - Public health KW - Veterinary medicine KW - bioterrorism KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257782534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosecurity+and+Bioterrorism&rft.atitle=The+Medical+Reserve+Corps+as+Part+of+the+Federal+Medical+and+Public+Health+Response+in+Disaster+Settings&rft.au=Frasca&rft.aulast=Frasca&rft.aufirst=&rft.date=2010-09-08&rft.volume=8&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Biosecurity+and+Bioterrorism&rft.issn=15387135&rft_id=info:doi/10.1089%2Fbsp.2010.0006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2013-01-11 N1 - SubjectsTermNotLitGenreText - Hurricanes; Veterinary medicine; bioterrorism; Community involvement; Nursing; Disasters; Dentistry; Medical personnel; Public health DO - http://dx.doi.org/10.1089/bsp.2010.0006 ER - TY - JOUR T1 - Stability of the Neurotensin Receptor NTS1 Free in Detergent Solution and Immobilized to Affinity Resin AN - 954581383; 13748883 AB - Purification of recombinant membrane receptors is commonly achieved by use of an affinity tag followed by an additional chromatography step if required. This second step may exploit specific receptor properties such as ligand binding. However, the effects of multiple purification steps on protein yield and integrity are often poorly documented. We have previously reported a robust two-step purification procedure for the recombinant rat neurotensin receptor NTS1 to give milligram quantities of functional receptor protein. First, histidine-tagged receptors are enriched by immobilized metal affinity chromatography using Ni-NTA resin. Second, remaining contaminants in the Ni-NTA column eluate are removed by use of a subsequent neurotensin column yielding pure NTS1. Whilst the neurotensin column eluate contained functional receptor protein, we observed in the neurotensin column flow-through misfolded NTS1. To investigate the origin of the misfolded receptors, we estimated the amount of functional and misfolded NTS1 at each purification step by radio-ligand binding, densitometry of Coomassie stained SDS-gels, and protein content determination. First, we observed that correctly folded NTS1 suffers damage by exposure to detergent and various buffer compositions as seen by the loss of [3H]neurotensin binding over time. Second, exposure to the neurotensin affinity resin generated additional misfolded receptor protein. Our data point towards two ways by which misfolded NTS1 may be generated: Damage by exposure to buffer components and by close contact of the receptor to the neurotensin affinity resin. Because NTS1 in detergent solution is stabilized by neurotensin, we speculate that the occurrence of aggregated receptor after contact with the neurotensin resin is the consequence of perturbations in the detergent belt surrounding the NTS1 transmembrane core. Both effects reduce the yield of functional receptor protein. JF - PLoS ONE AU - White, Jim F AU - Grisshammer, Reinhard AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America Y1 - 2010/09/07/ PY - 2010 DA - 2010 Sep 07 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 5 IS - 9 KW - Toxicology Abstracts KW - Affinity chromatography KW - Neurotensin KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954581383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Stability+of+the+Neurotensin+Receptor+NTS1+Free+in+Detergent+Solution+and+Immobilized+to+Affinity+Resin&rft.au=White%2C+Jim+F%3BGrisshammer%2C+Reinhard&rft.aulast=White&rft.aufirst=Jim&rft.date=2010-09-07&rft.volume=5&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0012579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Neurotensin DO - http://dx.doi.org/10.1371/journal.pone.0012579 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats AN - 954521659; 13366062 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal Sprague-Dawley rats by oral and injection routes. Deuterated BPA was used to avoid issues of background contamination. Linear pharmacokinetics were observed in adult rats treated orally in the range of 0-200I14g/kg bw. Evidence for enterohepatic recirculation of conjugated, but not aglycone, BPA was observed in adult rats. Significant inverse relationships were observed between postnatal age and measures of internal exposures to aglycone BPA and its elimination. In neonatal rats treated orally, internal exposures to aglycone BPA were substantially lower than from subcutaneous injection. The results reinforce the critical role for first-pass Phase II metabolism of BPA in gut and liver after oral exposure that attenuates internal exposure to the aglycone form in rats of all ages. The internal exposures to aglycone BPA observed in adult and neonatal rats following a single oral dose of 100I14g/kg bw are inconsistent with effects mediated by classical estrogen receptors based on binding affinities. However, an impact on alternative estrogen signaling pathways that have higher receptor affinity cannot be excluded in neonatal rats. These findings emphasize the importance of matching aglycone BPA internal dosimetry with receptor affinities in experimental animal studies reporting toxicity. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 158 EP - 165 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 247 IS - 2 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Rats KW - Aglycones KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954521659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+neonatal+and+adult+Sprague-Dawley+rats&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2010-09-01&rft.volume=247&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Aglycones; Rats DO - http://dx.doi.org/10.1016/j.taap.2010.06.008 ER - TY - JOUR T1 - Carbohydrate metabolic pathway genes associated with quantitative trait loci (QTL) for obesity and type 2 diabetes: Identification by data mining AN - 888099251; 15039606 AB - Increasing consumption of refined carbohydrates is now being recognized as a primary contributor to the development of nutritionally related chronic diseases such as obesity and type 2 diabetes mellitus (T2DM). A data mining approach was used to evaluate the role of carbohydrate metabolic pathway genes in the development of obesity and T2DM. Data from public databases were used to map the position of the carbohydrate metabolic pathway genes to known quantitative trait loci (QTL) for obesity and T2DM and for examining the pathway genes for the presence of sequence and structural genetic variants such as single nucleotide polymorphisms (SNPs) and copy number variants (CNS), respectively. The results demonstrated that a majority of the genes of the carbohydrate metabolic pathways are associated with QTL for obesity and many for T2DM. In addition, some key genes of the pathways also encode non-synonymous SNPs that exhibit significant differences in population frequencies. This study emphasizes the significance of the metabolic pathways genes in the development of disease phenotypes, its differential occurrence across populations and between individuals, and a strategy for interpreting an individuals' risk for disease. JF - Biotechnology Journal AU - Varma, Vijayalakshmi AU - Wise, Carolyn AU - Kaput, Jim Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 942 EP - 949 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 5 IS - 9 SN - 1860-7314, 1860-7314 KW - Genetics Abstracts; Physical Education Index; Biotechnology and Bioengineering Abstracts KW - Carbohydrates KW - Central nervous system KW - Chronic diseases KW - Data processing KW - Databases KW - Diabetes KW - Diabetes mellitus KW - Diseases KW - Genetics KW - Metabolic pathways KW - Obesity KW - Quantitative trait loci KW - Single-nucleotide polymorphism KW - Strategy KW - copy number KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Journal&rft.atitle=Carbohydrate+metabolic+pathway+genes+associated+with+quantitative+trait+loci+%28QTL%29+for+obesity+and+type+2+diabetes%3A+Identification+by+data+mining&rft.au=Varma%2C+Vijayalakshmi%3BWise%2C+Carolyn%3BKaput%2C+Jim&rft.aulast=Varma&rft.aufirst=Vijayalakshmi&rft.date=2010-09-01&rft.volume=5&rft.issue=9&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Journal&rft.issn=18607314&rft_id=info:doi/10.1002%2Fbiot.201000067 L2 - http://onlinelibrary.wiley.com/doi/10.1002/biot.201000067/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Genetics; Obesity; Strategy; Chronic diseases; Diseases; Carbohydrates; Diabetes; Diabetes mellitus; Databases; Central nervous system; Quantitative trait loci; Data processing; Single-nucleotide polymorphism; Metabolic pathways; copy number DO - http://dx.doi.org/10.1002/biot.201000067 ER - TY - GEN T1 - Highlights from the Technical Assistance and Child Care Resources Sponsored by the Office of Child Care. Office of Child Care Pathways and Partnerships Priorities. Issue Number 2 AN - 881464751; ED520493 AB - The Office of Child Care (OCC) administers the Child Care and Development Fund (CCDF) program, a multibillion-dollar Federal and State partnership to support access to high-quality child care for working families. OCC helps States, Territories, and Tribes administer their CCDF programs through program support, policy guidance, technical assistance, and research. This OCC newsletter contains the following: (1) Resource Spotlight on School-Age and Quality Rating and Improvement Systems; (2) Emerging Projects; (3) Targeted Resources: School-Age Care; (4) Spotlight on New Resources; (5) Planned Technical Assistance Activities; and (6) School-Age Quick Facts. (Contains 7 endnotes.) Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 2 PB - Office of Child Care. US Department of Health and Human Services, Administration for Children and Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - Rhode Island KW - Minnesota KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Partnerships in Education KW - Employed Parents KW - Resource Materials KW - Child Care KW - Educational Improvement KW - Quality Control KW - Technical Assistance KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881464751?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOEUGENOL (CAS NO. 97-54-1) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878683494; 21372857 AB - Isoeugenol is a fragrant oil found in many plants including clove, nutmeg, sandalwood, dill seed, gardenia and petunia. It is used in cleaning products, perfumes, and foods and also as an anesthetic in fisheries. We studied the effects of isoeugenol on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing isoeugenol in corn oil directly into the stomach through a tube to groups of 50 male and female rats and mice for two years. Exposed animals received either 75, 150, or 300 milligrams of isoeugenol per kilogram of body weight. Control animals received corn oil with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. There were increased rates of liver cancer (hepatocellular adenoma and hepatocellular carcinoma) in male mice exposed to isoeugenol. Two male rats given 300 mg/kg isoeugenol developed rare neoplasms of the thyroid gland and two others developed rare mammary gland carcinomas. There was an increased rate of histiocytic sarcomas in female mice exposed to isoeugenol. Atrophy, metaplasia, or degeneration of the olfactory epithelium of the nose was seen in all groups of male and female rats and mice exposed to isoeugenol. We conclude that isoeugenol caused liver cancer in male mice. The occurrence of rare thyroid and mammary gland tumors in male rats and increased incidences of histiocytic sarcomas in female mice may have been associated with exposure to isoeugenol. Exposure to isoeugenol caused a variety of lesions of the olfactory epithelium of the nose in rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 178 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Eugenol KW - isoeugenol KW - Rodents KW - Genetics KW - Carcinogens KW - Chemical compounds KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Eugenol -- toxicity KW - Dose-Response Relationship, Drug KW - Humans KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Eugenol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+ISOEUGENOL+%28CAS+NO.+97-54-1%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=551&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683493 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=551&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683492 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683491 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+and+risk+assessment+of+trace+elements+in+foods+from+Taiwan+containing+red+mould+rice+%28Monascus%29+by+ICP-MS&rft.au=Tsai%2C+C-F%3BShih%2C+DY-C%3BShyu%2C+Y-T&rft.aulast=Tsai&rft.aufirst=C-F&rft.date=2010-12-01&rft.volume=3&rft.issue=4&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.issn=19393210&rft_id=info:doi/10.1080%2F19393210.2010.513070 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683358 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA [CAS NO. 481-72-1 (Aloe-emodin)] IN SKH-1 MICE (SIMULATED SOLAR LIGHT AND TOPICAL APPLICATION STUDY) AN - 878683355; 21031007 AB - Extracts from the Aloe vera plant are widely used in skin care products. We studied the effects of synthetic solar light on the skin of hairless mice that had been treated with creams containing various Aloe vera extracts. We applied creams containing Aloe vera plant extracts (aloe gel, whole leaf, or decolorized whole leaf) or aloe-emodin to groups of 36 male and female hairless mice in the morning; other groups received creams containing no aloe. In the afternoon groups of animals were exposed to synthetic solar light for four hours. Other groups were not exposed to light and were control groups. The treatments and exposures were performed five days per week for 40 weeks, during which the animals were monitored for development of skin cancers. Mice exposed to synthetic solar light developed significant increases in squamous cell neoplasms and squamous cell nonneoplastic lesions of the skin whether or not they received treatment with cream. Female mice, but not male mice, treated with aloe gel or aloe-emodin and exposed to simulated solar light had increased numbers of squamous cell neoplasms when compared with mice treated with the carrier cream without the aloe gel or aloe-emodin and exposed to the same intensity of light. For both male and female mice, inclusion of aloe whole leaf extract or decolorized leaf extract in the cream increased the number of squamous cell neoplasms when the animals were exposed to simulated solar light. We conclude that aloe gel or aloe-emodin had a weak enhancing effect on the photocarcinogenic activity of simulated solar light in female but not male hairless mice. We conclude that aloe whole leaf extract and decolorized leaf extract had a weak enhancing effect on the photocarcinogenic activity of simulated solar light in both male and female hairless mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 33, 35-97, 99-103 passim CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Plant Extracts KW - Skin cancer KW - Radiation KW - Flowers & plants KW - Skin care products KW - Animals KW - Carcinogenicity Tests KW - Mice KW - Mice, Hairless KW - Male KW - Female KW - Administration, Topical KW - Aloe -- toxicity KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Plant Extracts -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+PHOTOCOCARCINOGENESIS+STUDY+OF+ALOE+VERA+%5BCAS+NO.+481-72-1+%28Aloe-emodin%29%5D+IN+SKH-1+MICE+%28SIMULATED+SOLAR+LIGHT+AND+TOPICAL+APPLICATION+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Exposure science can increase protection of workers and their families from exposure to asbestos and inform on the effects of other elongate mineral particles AN - 877596953; 13709746 JF - Journal of Exposure Science and Environmental Epidemiology AU - Howard, John AU - Middendorf, Paul AD - National Institute for Occupational Safety and Health, Washington, DC, USA Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 485 EP - 486 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 6 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Asbestos KW - Particulates KW - Minerals KW - Occupational exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877596953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Exposure+science+can+increase+protection+of+workers+and+their+families+from+exposure+to+asbestos+and+inform+on+the+effects+of+other+elongate+mineral+particles&rft.au=Howard%2C+John%3BMiddendorf%2C+Paul&rft.aulast=Howard&rft.aufirst=John&rft.date=2010-09-01&rft.volume=20&rft.issue=6&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2010.40 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Asbestos; Particulates; Minerals; Occupational exposure DO - http://dx.doi.org/10.1038/jes.2010.40 ER - TY - JOUR T1 - Formulation and stability of a novel artificial human sweat under conditions of storage and use AN - 877589600; 13668023 AB - A limitation of most artificial sweat formulations used for in vitro assessment of chemical release from materials in contact with skin have little biological relevance to human sweat. The purposes of this paper are to provide guidance for preparation of a novel artificial sweat with chemical constituents at concentrations that match human sweat and to characterize chemical stability. The artificial sweat was characterized under conditions of use (with and without sebum at 36AC) and storage (without sebum at a4, 4, and 23AC) over 28days by gas chromatography-mass spectroscopy, high-performance liquid chromatography, enzymatic assay kits, and ion-selective electrodes. Seven indicator constituents were tracked: sodium, chloride, glucose, lactic acid, urea, pantothenic acid, and alanine. With or without sebum at 36AC, the sweat solvent was chemically stable for 14days. Storage by refrigeration at 4AC retained the chemical integrity of the solvent longest. Based on these results, the solvent should be used within 14days of preparation. The artificial sweat model presented herein is most similar to human sweat and has applications as a dissolution solvent, donor solution in diffusion cells, or vehicle for patch testing. This sweat model may aid researchers in understanding potential release and percutaneous absorption of chemicals in contact with human skin surface liquids. JF - Toxicology In Vitro AU - Harvey, Christopher J AU - LeBouf, Ryan F AU - Stefaniak, Aleksandr B AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA, AStefaniak@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1790 EP - 1796 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 24 IS - 6 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - Alanine KW - Sweat KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877589600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Formulation+and+stability+of+a+novel+artificial+human+sweat+under+conditions+of+storage+and+use&rft.au=Harvey%2C+Christopher+J%3BLeBouf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B&rft.aulast=Harvey&rft.aufirst=Christopher&rft.date=2010-09-01&rft.volume=24&rft.issue=6&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2010.06.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Sweat DO - http://dx.doi.org/10.1016/j.tiv.2010.06.016 ER - TY - JOUR T1 - Metal-based nanoparticles and their toxicity assessment AN - 869590347; 14821164 AB - Nanoparticles (NPs) can potentially cause adverse effects on organ, tissue, cellular, subcellular, and protein levels due to their unusual physicochemical properties (e.g., small size, high surface area to volume ratio, chemical composition, crystallinity, electronic properties, surface structure reactivity and functional groups, inorganic or organic coatings, solubility, shape, and aggregation behavior). Metal NPs, in particular, have received increasing interest due to their widespread medical, consumer, industrial, and military applications. However, as particle size decreases, some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form (e.g., Ag, Au, and Cu). NPs also interact with proteins and enzymes within mammalian cells and they can interfere with the antioxidant defense mechanism leading to reactive oxygen species generation, the initiation of an inflammatory response and perturbation and destruction of the mitochondria causing apoptosis or necrosis. As a result, there are many challenges to overcome before we can determine if the benefits outweigh the risks associated with NPs. WIREs Nanomed Nanobiotechnol 2010 2 544-568 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Schrand, Amanda M AU - Rahman, Mohammad F AU - Hussain, Saber M AU - Schlager, John J AU - Smith, David A AU - Syed, Ali F AD - Wright-Patterson Air Force Base, Dayton, OH 45433, USA, syed.ali@fda.hhs.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 544 EP - 568 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 5 SN - 1939-0041, 1939-0041 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Particle size KW - Metals KW - Crystallinity KW - Solubility KW - Antioxidants KW - Apoptosis KW - Surface area KW - Physicochemical properties KW - Mitochondria KW - Enzymes KW - Copper KW - Toxicity KW - Inflammation KW - Aggregation behavior KW - Necrosis KW - Mammalian cells KW - Reactive oxygen species KW - Consumers KW - Defense mechanisms KW - nanoparticles KW - Side effects KW - nanotechnology KW - Coatings KW - W 30910:Imaging KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869590347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Metal-based+nanoparticles+and+their+toxicity+assessment&rft.au=Schrand%2C+Amanda+M%3BRahman%2C+Mohammad+F%3BHussain%2C+Saber+M%3BSchlager%2C+John+J%3BSmith%2C+David+A%3BSyed%2C+Ali+F&rft.aulast=Schrand&rft.aufirst=Amanda&rft.date=2010-09-01&rft.volume=2&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Particle size; Metals; Crystallinity; Apoptosis; Antioxidants; Solubility; Surface area; Physicochemical properties; Enzymes; Mitochondria; Toxicity; Copper; Inflammation; Necrosis; Aggregation behavior; Reactive oxygen species; Mammalian cells; Consumers; Defense mechanisms; nanoparticles; Side effects; Coatings; nanotechnology DO - http://dx.doi.org/10.1002/wnan.103 ER - TY - JOUR T1 - Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production AN - 869574563; 14821722 AB - Hyaluronic acid (HA) is increasingly used for a number of medical device applications. Since the chemical structure of HA is identical no matter its bacterial or animal origin, it should be the ideal biomaterial. However, short term transient inflammatory reactions are common, while rare long-term adverse events may correlate with subclinical chronic inflammation. Concern has been raised that low molecular weight components or degradation fragments from implanted HA may directly stimulate inflammatory reactions. This study examined a panel of HA molecular weights from the unitary disaccharide up to 1.7 x 10 super(6) Dalton lengths, in which endotoxin was assayed at a very low level (less than 0.03 EU/mg). The murine cell line RAW 264.7, rat splenocytes, and rat adherent differentiated primary macrophages were assayed for nitric oxide production under a variety of inflammatory conditions plus or minus HA. Under the highest inflammatory states, nitric oxide production was mildly suppressed by HMW-HA while slightly augmented by LMW-HA at mg/mL concentrations. However, at micromolar concentrations fragments below 5000 Daltons, thought to have drug-like qualities, were without effect. These data support the hypothesis that if endotoxin is reduced to an extremely low level, LMW-HA may not directly provoke normal tissue macrophage-mediated inflammatory reactions. JF - Journal of Biomedical Materials Research, Part A AU - Lyle, Daniel B AU - Breger, Joyce C AU - Baeva, Larissa F AU - Shallcross, Jonathan C AU - Durfor, Charles N AU - Wang, Nam Sun AU - Langone, John J AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, FDA, 10903 New Hampshire Ave, Silver Spring, Maryland 20993-002, john.langone@fda.hhs.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 893 EP - 904 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 94A IS - 3 SN - 1552-4965, 1552-4965 KW - Biotechnology and Bioengineering Abstracts KW - biomaterials KW - nitric oxide KW - inflammation KW - macrophage KW - hyaluronic acid KW - Endotoxins KW - Macrophages KW - Hyaluronic acid KW - Splenocytes KW - Data processing KW - Molecular weight KW - Biomaterials KW - Nitric oxide KW - Inflammation KW - Disaccharides KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869574563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.atitle=Low+molecular+weight+hyaluronic+acid+effects+on+murine+macrophage+nitric+oxide+production&rft.au=Lyle%2C+Daniel+B%3BBreger%2C+Joyce+C%3BBaeva%2C+Larissa+F%3BShallcross%2C+Jonathan+C%3BDurfor%2C+Charles+N%3BWang%2C+Nam+Sun%3BLangone%2C+John+J&rft.aulast=Lyle&rft.aufirst=Daniel&rft.date=2010-09-01&rft.volume=94A&rft.issue=3&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.issn=15524965&rft_id=info:doi/10.1002%2Fjbm.a.32760 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Endotoxins; Splenocytes; Hyaluronic acid; Data processing; Molecular weight; Biomaterials; Nitric oxide; Disaccharides; Inflammation DO - http://dx.doi.org/10.1002/jbm.a.32760 ER - TY - JOUR T1 - Well-being at work - overview and perspective AN - 867745940; 13674293 AB - This paper provides an overview of and perspective on the concept of well-being at work. Well-being is a term that reflects not only on one's health but satisfaction with work and life. Well-being is a summative concept that characterizes the quality of working lives, including occupational safety and health (OSH) aspects, and it may be a major determinant of productivity at the individual, enterprise and societal levels. Based on a review of the literature and a recent conference, we suggest a model linking workforce well-being, productivity, and population well-being. To appraise the validity of the model, we consider five questions: (i) is there a robust and usable definition of workplace well-being? (ii) have the variables that influence well-being been aptly described and can they be measured and used in risk assessments? (iii) what is the nature of evidence that well-being is linked to productivity? (iv) what is the state of knowledge on the effectiveness of interventions to promote workplace well-being? and (v) should interventions aimed at improving well-being at work focus on more than work-related factors?. JF - Scandinavian Journal of Work, Environment & Health AU - Schulte, P AU - Vainio, H AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, Ohio 45226, USA, pschulte@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 422 EP - 429 VL - 36 IS - 5 SN - 0355-3140, 0355-3140 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Conferences KW - intervention KW - Reviews KW - Occupational safety KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867745940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Well-being+at+work+-+overview+and+perspective&rft.au=Schulte%2C+P%3BVainio%2C+H&rft.aulast=Schulte&rft.aufirst=P&rft.date=2010-09-01&rft.volume=36&rft.issue=5&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Conferences; Reviews; intervention; Occupational safety ER - TY - JOUR T1 - The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the a7 nicotinic receptor AN - 867741147; 13823806 AB - J. Neurochem. (2010) 114, 1659-1666.AbstractVoltammetric analyses show that low (100-500 nM) doses of nicotine regulate striatal dopamine by inhibiting release evoked by a single stimulation to a greater extent than release evoked by high frequency stimulations. This frequency-dependent inhibition is because of nicotine desensitizing heteromeric b2 subunit-containing nicotinic acetylcholine receptor (nAChR) subtypes. Surprisingly, a high dose of nicotine (2 kM; capable of interacting with additional nAChR subtypes) produced an inhibition of dopamine evoked by high frequency stimulation, an effect that was not seen with the low dose of nicotine or the b2 antagonist, dihydro-b-erythroidine hydrobromide. This inhibition was replicated by application of a7 nAChR antagonists methyllcaconitine citrate or a-bungarotoxin in conjunction with the low dose of nicotine or dihydro-b-erythroidine hydrobromide. Blocking a7 receptor function alone produced a modest increase in dopamine evoked by single pulse stimulation while not affecting dopamine evoked by high frequency stimulation. The antagonist results were mimicked using selective a7 agonists PHA 543613 and PNU 282987. The frequency dependence of the low dose nicotine inhibition therefore requires functional a7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation. JF - Journal of Neurochemistry AU - Seipel, Andrew T AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA, yakel@niehs.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1659 EP - 1666 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 6 SN - 0022-3042, 0022-3042 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Acetylcholine receptors (nicotinic) KW - Bungarotoxin KW - Citric acid KW - Dopamine KW - Frequency dependence KW - Neostriatum KW - Nicotine KW - Receptor mechanisms KW - X 24380:Social Poisons & Drug Abuse KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISME+Journal&rft.atitle=Population+dynamics+of+Vibrio+spp.+associated+with+marine+sponge+microcosms&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BOttesen%2C+Andrea%3BMcCarthy%2C+Peter+J%3BLopez%2C+Jose+V%3BBrown%2C+Eric+W%3BMonday%2C+Steven+R&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-12-01&rft.volume=4&rft.issue=12&rft.spage=1608&rft.isbn=&rft.btitle=&rft.title=ISME+Journal&rft.issn=17517362&rft_id=info:doi/10.1038%2Fismej.2010.85 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Number of references - 25 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Dopamine; Bungarotoxin; Receptor mechanisms; Nicotine; Neostriatum; Frequency dependence; Acetylcholine receptors (nicotinic); Citric acid DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06883.x ER - TY - JOUR T1 - Real-Time PCR Assay for the Detection of Pufferfish Products AN - 860372032; 13709712 AB - An assay was developed for the rapid detection of products containing tissues from potentially toxic pufferfish (family Tetraodontidae), as part of the U.S. Food and Drug Administration Center for Veterinary Medicine and Center for Food Safety and Applied Nutrition's charter to protect human health. In this study, we developed a TaqMan assay derived from DNA barcode data (650 bp starting at the 5' end of the mitochondrial cytochrome c oxidase I gene) for the specific detection of pufferfish. The method requires only 1 h of total run time, a significant improvement over current methods, which can require 24 to 96 h for completion. The probes were tested against 105 species of fish and were able to detect 20 species of pufferfish; no cross-reactivity was shown with 85 species of nonpufferfish, including 20 related species from the same order (Tetraodontiformes). These results demonstrate that this assay is suitable for the rapid and specific detection of pufferfish and that it could be a useful regulatory tool to protect human health. JF - Journal of Food Protection AU - Jones, Yolanda L AU - Oliver, Haley F AU - Deeds, Jonathan R AU - Yancy, Haile F AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708; 2 Cornell University, Department of Food Science, 410B Stocking Hall, Ithaca, New York 14860; and 3U.S. Food and Drug Administration, Center for Food Safetyand Applied Nutrition, 5100 Paintbranch Parkway, College Park, Maryland 20740, USA, Yolanda.Jones@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1698 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 73 IS - 9 SN - 0362-028X, 0362-028X KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Cytochromes KW - Nucleotide sequence KW - Animal physiology KW - Toxicity KW - Nutrition KW - Public health KW - Marine fish KW - Tetraodontiformes KW - USA KW - DNA KW - Tetraodontidae KW - Drugs KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q5 08504:Effects on organisms KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860372032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Real-Time+PCR+Assay+for+the+Detection+of+Pufferfish+Products&rft.au=Jones%2C+Yolanda+L%3BOliver%2C+Haley+F%3BDeeds%2C+Jonathan+R%3BYancy%2C+Haile+F&rft.aulast=Jones&rft.aufirst=Yolanda&rft.date=2010-09-01&rft.volume=73&rft.issue=9&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 28 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Marine fish; Cytochromes; Nucleotide sequence; DNA; Animal physiology; Toxicity; Drugs; Nutrition; Public health; Tetraodontiformes; Tetraodontidae; USA; Marine ER - TY - JOUR T1 - Performance Testing of Huber Needles for Coring of Port Septa AN - 818840960; 13791063 AB - The Food and Drug Administration received complaints of Huber needles creating cores in the septa of ports of gastric banding devices. One of these complaints represented a cluster of similar events, even though no deviations from design specifications or recommended practices were subsequently identified by the manufacturer. The authors conducted this comparative investigation of off-the-shelf Huber needles and ports from several manufacturers to determine if engineering parameters could be identified that could account for the coring complaints. Huber needles from ten manufacturers were evaluated for coring using intravascular access ports from five manufacturers. A detailed optical analysis was also performed to identify needle features that would possibly account for coring. The majority of the tested needles performed as they should, i.e., they perforated the port septa without creating cores. However, needles that did produce cores were found to have sharp edges at the heel edge of the needle lumen, the edge of the ground bevel opposite from the needle tip that opens to the inner surface of the cannula tube. Manufacturing processes, which dulled or rounded the sharp heel of the bevel after bevel grinding, prevented coring. As a result of this investigation one manufacturer voluntarily recalled their product and another manufacturer implemented coring testing as part of their quality control. To prevent coring needles from entering the market as a result of manufacturing flaws, optical inspection of the heel edge and coring testing should be performed as part of routine quality control. JF - Journal of Medical Devices (Transactions of the ASME) AU - Vesnovsky, Oleg AU - Casamento, Jon P AU - Brooks, Mary E AU - Schwerin, Matthew R AU - Herman, William A AU - Pollack, Steven K AU - Flack, Marilyn N AU - Collins, Betty W AU - Grossman, Laurence W AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993 Y1 - 2010/09// PY - 2010 DA - Sep 2010 PB - ASME International, 22 Law Drive Fairfield NJ 07007-2900 USA VL - 4 IS - 3 SN - 1932-6181, 1932-6181 KW - Biotechnology and Bioengineering Abstracts KW - Coring KW - Quality control KW - Septum KW - Banding KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818840960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Devices+%28Transactions+of+the+ASME%29&rft.atitle=Performance+Testing+of+Huber+Needles+for+Coring+of+Port+Septa&rft.au=Vesnovsky%2C+Oleg%3BCasamento%2C+Jon+P%3BBrooks%2C+Mary+E%3BSchwerin%2C+Matthew+R%3BHerman%2C+William+A%3BPollack%2C+Steven+K%3BFlack%2C+Marilyn+N%3BCollins%2C+Betty+W%3BGrossman%2C+Laurence+W&rft.aulast=Vesnovsky&rft.aufirst=Oleg&rft.date=2010-09-01&rft.volume=4&rft.issue=3&rft.spage=031008+%287%29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Devices+%28Transactions+of+the+ASME%29&rft.issn=19326181&rft_id=info:doi/10.1115%2F1.4001866YouarenotloggedintotheASMEDigitalLibrary. L2 - http://asmedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JMDOA4000004000003031008000001&idtype=cvips&gifs=Yes LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Coring; Quality control; Banding; Septum DO - http://dx.doi.org/10.1115/1.4001866YouarenotloggedintotheASMEDigitalLibrary. ER - TY - JOUR T1 - In situ estimation of roof rock strength using sonic logging AN - 818639392; 2011-006426 AB - Sonic travel time logging of exploration boreholes is routinely used in Australia to obtain estimates of coal mine roof rock strength. Because sonic velocity logs are relatively inexpensive and easy to obtain during exploration, the technique has provided Australian underground coal mines with an abundance of rock strength data for use in all aspects of ground control design. However, the technique depends upon reliable correlations between the uniaxial compressive strength (UCS) and the sonic velocity. This paper describes research recently conducted by NIOSH aimed at developing a correlation for use by the U.S. mining industry. From two coreholes in Illinois, two from Pennsylvania, and one each from Colorado, western Kentucky and southern West Virginia, sonic velocity logs were compared with UCS values derived from Point Load tests for a broad range of coal measure rock types. For the entire data set, the relationship between UCS and sonic travel time is expressed by an exponential equation relating the UCS in psi to the travel time of the P-wave in mu s/ft. The coefficient of determination or R-squared for this equation is 0.72, indicating that a relatively high reliability can be achieved with this technique. The strength estimates obtained from the correlation equation may be used to help design roof support systems. The paper also addresses the steps that are necessary to ensure that high-quality sonic logs are obtained for use in estimating UCS. JF - International Journal of Coal Geology AU - Oyler, David C AU - Mark, Christopher AU - Molinda, Gregory M Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 484 EP - 490 PB - Elsevier, Amsterdam VL - 83 IS - 4 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - underground mining KW - roof control KW - well-logging KW - coal fields KW - uniaxial tests KW - rock mechanics KW - sedimentary rocks KW - coal KW - Australia KW - mines KW - well logs KW - Illinois KW - Australasia KW - geophysical methods KW - coal mines KW - equations KW - depth KW - physical properties KW - boreholes KW - acoustical logging KW - compressive strength KW - Pennsylvania KW - coal deposits KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818639392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=In+situ+estimation+of+roof+rock+strength+using+sonic+logging&rft.au=Oyler%2C+David+C%3BMark%2C+Christopher%3BMolinda%2C+Gregory+M&rft.aulast=Oyler&rft.aufirst=David&rft.date=2010-09-01&rft.volume=83&rft.issue=4&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.07.002 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustical logging; Australasia; Australia; boreholes; coal; coal deposits; coal fields; coal mines; compressive strength; depth; equations; geophysical methods; Illinois; mines; mining; Pennsylvania; physical properties; rock mechanics; roof control; sedimentary rocks; underground mining; uniaxial tests; United States; well logs; well-logging DO - http://dx.doi.org/10.1016/j.coal.2010.07.002 ER - TY - JOUR T1 - Evaluation of Pulsed-Field Gel Electrophoresis Profiles for Identification of Salmonella Serotypes AN - 807261523; 13664879 AB - Pulsed-field gel electrophoresis (PFGE) is a standard typing method for isolates from Salmonella outbreaks and epidemiological investigations. Eight hundred sixty-six Salmonella enterica isolates from eight serotypes, including Heidelberg (n = 323), Javiana (n = 200), Typhimurium (n = 163), Newport (n = 93), Enteritidis (n = 45), Dublin (n = 25), Pullorum (n = 9), and Choleraesuis (n = 8), were subjected to PFGE, and their profiles were analyzed by random forest classification and compared to conventional hierarchical cluster analysis to determine potential predictive relationships between PFGE banding patterns and particular serotypes. Cluster analysis displayed only the underlying similarities and relationships of the isolates from the eight serotypes. However, for serotype prediction of a nonserotyped Salmonella isolate from its PFGE pattern, random forest classification provided better accuracy than conventional cluster analysis. Discriminatory DNA band class markers were identified for distinguishing Salmonella serotype Heidelberg, Javiana, Typhimurium, and Newport isolates. JF - Journal of Clinical Microbiology AU - Zou, Wen AU - Lin, Wei-Jiun AU - Foley, Steven L AU - Chen, Chun-Houh AU - Nayak, Rajesh AU - Chen, James J AD - Division of Personalized Nutrition and Medicine, jamesj.chen@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 3122 EP - 3126 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Typing KW - Classification KW - Salmonella enterica KW - Pulsed-field gel electrophoresis KW - DNA KW - Forests KW - Pest outbreaks KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807261523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Pulsed-Field+Gel+Electrophoresis+Profiles+for+Identification+of+Salmonella+Serotypes&rft.au=Zou%2C+Wen%3BLin%2C+Wei-Jiun%3BFoley%2C+Steven+L%3BChen%2C+Chun-Houh%3BNayak%2C+Rajesh%3BChen%2C+James+J&rft.aulast=Zou&rft.aufirst=Wen&rft.date=2010-09-01&rft.volume=48&rft.issue=9&rft.spage=3122&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00645-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 22 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Typing; Serotypes; Classification; DNA; Pulsed-field gel electrophoresis; Forests; Pest outbreaks; Salmonella enterica DO - http://dx.doi.org/10.1128/JCM.00645-10 ER - TY - JOUR T1 - Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA AN - 807260662; 13666653 AB - SummaryA prominent feature of the promoters of Bordetella pertussis fimbrial subunit genes fim2, fim3 and fimX is the presence of a 'C-stretch', a monotonic run of C residues. The C-stretch renders these genes capable of phase variation, through spontaneous variations in its length. For each of these we determined the length of the C-stretch that gave maximal transcriptional activity, and found that the three optimized promoters align perfectly, with identical distances between conserved upstream sequences and the downstream -10 elements and transcriptional start sites. We also demonstrated, for Pfim3, that the conserved sequence corresponds to BvgA binding sites. The more upstream of the two binding sites is predicted to be high affinity, by comparison to a functionally derived consensus BvgA-binding sequence. The other binding site is a fairly poor match to this consensus, with 10 of 14 bp belonging to the C-stretch. Interestingly, the centre of this downstream site of BvgA binding coincides exactly with the centre of the expected typical location of a -35 sequence. However, the lack of a recognizable -35 element (CCCCCC versus TTGACA), and the occupation of this site by BvgA6P suggest that activation of the fim promoters involves unusual interactions among BvgA, RNA polymerase and promoter DNA. JF - Molecular Microbiology AU - Chen, Qing AU - Decker, Kimberly Baxter AU - Boucher, Philip E AU - Hinton, Deborah AU - Stibitz, Scott AD - 1Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1326 EP - 1340 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 77 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - Pertussis KW - Bordetella pertussis KW - DNA-directed RNA polymerase KW - Phase variations KW - DNA KW - Conserved sequence KW - Transcription KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807260662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Novel+architectural+features+of+Bordetella+pertussis+fimbrial+subunit+promoters+and+their+activation+by+the+global+virulence+regulator+BvgA&rft.au=Chen%2C+Qing%3BDecker%2C+Kimberly+Baxter%3BBoucher%2C+Philip+E%3BHinton%2C+Deborah%3BStibitz%2C+Scott&rft.aulast=Chen&rft.aufirst=Qing&rft.date=2010-09-01&rft.volume=77&rft.issue=5&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2010.07293.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 45 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Virulence; Pertussis; Promoters; DNA-directed RNA polymerase; Phase variations; DNA; Transcription; Conserved sequence; Bordetella pertussis DO - http://dx.doi.org/10.1111/j.1365-2958.2010.07293.x ER - TY - JOUR T1 - Effects of gloves on the total grip strength applied to cylindrical handles AN - 787287602; 13715405 AB - The major objectives of this study were to establish an alternative method for measuring the effects of gloves on the grip strength applied to cylindrical handles and to quantify the strength reduction due to the use of typical anti-vibration (AV) gloves. Different from previous studies that measure the grip force in a specific plane, the alternative method measures the total contact force normal to a cylindrical handle; the total grip strength is defined as the total contact force measured when a subject applies a power grip to the handle with his/her maximum voluntary contraction (MVC) effort. Two instrumented cylindrical handles (30 and 40 mm) were used in this study. ten subjects participated in the experiment. Four types of AV gloves and two types of non-AV gloves were used in the experiment. Compared with bare-handed trials, each of the four anti-vibration gloves reduced the grip strength by more than 29%, regardless of handle size. One of the non-AV gloves also largely reduced the grip strength (>=25%) whereas the grip strength reduction of the other one was less than 10%. The gloves also influenced the grip force distribution pattern around the circumference of the cylindrical handles. The results suggest that the thickness of a glove is one of the major factors associated with these effects. Relevance to industry - Glove use is generally recommended to keep the hands warm and dry and to protect them from many other hazards, provided this is consistent with safe and effective tool operation. However, a user of thicker, stiffer gloves, such as some AV gloves, could be trading one health risk for another. Knowledge of the effects of gloves on grip strength can help workers, managers, and safety professionals make informed decisions about glove selection and use in the workplace. This knowledge may also lead to work glove improvements. JF - International Journal of Industrial Ergonomics AU - Wimer, Bryan AU - McDowell, Thomas W AU - Xu, Xueyan S AU - Welcome, Daniel E AU - Warren, Christopher AU - Dong, Ren G AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA, TMcDowell@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 574 EP - 583 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 40 IS - 5 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Glove KW - Grip force KW - Grip strength KW - Anti-vibration gloves KW - Hand force KW - Risk assessment KW - gloves KW - Ergonomics KW - H 10000:Ergonomics/Human Factors KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787287602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Effects+of+gloves+on+the+total+grip+strength+applied+to+cylindrical+handles&rft.au=Wimer%2C+Bryan%3BMcDowell%2C+Thomas+W%3BXu%2C+Xueyan+S%3BWelcome%2C+Daniel+E%3BWarren%2C+Christopher%3BDong%2C+Ren+G&rft.aulast=Wimer&rft.aufirst=Bryan&rft.date=2010-09-01&rft.volume=40&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2010.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; gloves; Ergonomics DO - http://dx.doi.org/10.1016/j.ergon.2010.05.004 ER - TY - JOUR T1 - Measuring addiction propensity and severity: The need for a new instrument AN - 772276066; 201029810 AB - Drug addiction research requires but lacks a valid and reliable way to measure both the risk (propensity) to develop addiction and the severity of manifest addiction. This paper argues for a new measurement approach and instrument to quantify propensity to and severity of addiction, based on the testable assumption that these constructs can be mapped onto the same dimension of liability to addiction. The case for this new direction becomes clear from a critical review of empirical data and the current instrumentation. The many assessment instruments in use today have proven utility, reliability, and validity, but they are of limited use for evaluating individual differences in propensity and severity. The conceptual and methodological shortcomings of instruments currently used in research and clinical practice can be overcome through the use of new technologies to develop a reliable, valid, and standardized assessment instrument(s) to measure and distinguish individual variations in expression of the underlying latent trait(s) that comprises propensity to and severity of drug addiction. Such instrumentation would enhance our capacity for drug addiction research on linkages and interactions among familial, genetic, psychosocial, and neurobiological factors associated with variations in propensity and severity. It would lead to new opportunities in substance abuse prevention, treatment, and services research, as well as in interventions and implementation science for drug addiction. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Conway, Kevin P AU - Levy, Janet AU - Vanyukov, Michael AU - Chandler, Redonna AU - Rutter, Joni AU - Swan, Gary E AU - Neale, Michael AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Blvd., Room 5153, MSC 9589, Bethesda, MD 20892-9589, USA kconway@nida.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 4 EP - 12 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 111 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Tobacco Cannabis assessment Individual differences Adolescents KW - Clinical assessment KW - Severity KW - Psychosocial factors KW - Addiction KW - Drug addiction KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772276066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Measuring+addiction+propensity+and+severity%3A+The+need+for+a+new+instrument&rft.au=Conway%2C+Kevin+P%3BLevy%2C+Janet%3BVanyukov%2C+Michael%3BChandler%2C+Redonna%3BRutter%2C+Joni%3BSwan%2C+Gary+E%3BNeale%2C+Michael&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2010-09-01&rft.volume=111&rft.issue=1-2&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.03.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Drug addiction; Severity; Addiction; Substance abuse; Clinical assessment; Psychosocial factors DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.03.011 ER - TY - JOUR T1 - Fecal-Orally Transmitted Diseases Among Travelers Are Decreasing Due to Better Hygienic Standards at Travel Destination AN - 759313193; 13666584 AB - Objective. To evaluate whether changes in attack rates of fecal-orally transmitted diseases among travelers are related to changes in pretravel vaccination practices or better hygienic standards at travel destination. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Sonder, Gerard JB AU - van der Loeff, Maarten FSchim AU - Coutinho, Roel A AU - van den Hoek, Anneke AD - *Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands, gbaaten@ggd.amsterdam.nl Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 322 EP - 328 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 17 IS - 5 SN - 1195-1982, 1195-1982 KW - Health & Safety Science Abstracts KW - Hygiene KW - Travel KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Fecal-Orally+Transmitted+Diseases+Among+Travelers+Are+Decreasing+Due+to+Better+Hygienic+Standards+at+Travel+Destination&rft.au=Baaten%2C+Gijs+G%3BSonder%2C+Gerard+JB%3Bvan+der+Loeff%2C+Maarten+FSchim%3BCoutinho%2C+Roel+A%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2010-09-01&rft.volume=17&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2010.00442.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 14 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Travel; Hygiene DO - http://dx.doi.org/10.1111/j.1708-8305.2010.00442.x ER - TY - JOUR T1 - How HealthPlans, Health Systems, and Others in the Private Sector Canm Stimulate 'Meaningful Use' AN - 758116911; 2010-627798 AB - Provisions of the American Recovery & Reinvestment Act authorize incentive payments to hospitals & clinicians who become "meaningful users" of health information technology (IT). We argue that various private-sector entities -- commercial payers, employers, consumer groups, health care ratings organizations, large provider organizations, & regulatory bodies -- can further accelerate health IT adoption by implementing strategies that are complementary to the Medicare & Medicaid incentive programs. This paper describes these strategies & potential approaches to implementation. Adapted from the source document. JF - Health Affairs AU - Jain, Sachin H AU - Seidman, Joshua AU - Blumenthal, David AD - U.S. Dept Health & Human Services, Washington, D.C sachin.jain@hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1667 EP - 1670 PB - Project HOPE, Bethesda MD VL - 29 IS - 9 SN - 0278-2715, 0278-2715 KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Science and technology policy - Computer science and information technology KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Consumers and consumption KW - Health conditions and policy - Hospitals and other health care facilities KW - Information Technology KW - Insurance KW - Managed Care KW - Health Reform KW - Rating KW - Medicare KW - Health insurance KW - Consumers KW - Information technology KW - Medical service KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758116911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=How+HealthPlans%2C+Health+Systems%2C+and+Others+in+the+Private+Sector+Canm+Stimulate+%27Meaningful+Use%27&rft.au=Jain%2C+Sachin+H%3BSeidman%2C+Joshua%3BBlumenthal%2C+David&rft.aulast=Jain&rft.aufirst=Sachin&rft.date=2010-09-01&rft.volume=29&rft.issue=9&rft.spage=1667&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0766 LA - English DB - PAIS Index N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health insurance; Information technology; Medical service; Rating; Consumers; Hospitals; Medicare DO - http://dx.doi.org/10.1377/hlthaff.2010.0766 ER - TY - JOUR T1 - Nurses and the Affordable Care Act AN - 758112467; 201029369 AB - New legislation gives nurses a greater voice. Adapted from the source document. JF - American Journal of Nursing AU - Wakefield, Mary K AD - U.S. Health Resources & Services Administration, Washington, DC administrator@hrsa.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 11 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 110 IS - 9 SN - 0002-936X, 0002-936X KW - Nurses KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758112467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nursing&rft.atitle=Nurses+and+the+Affordable+Care+Act&rft.au=Wakefield%2C+Mary+K&rft.aulast=Wakefield&rft.aufirst=Mary&rft.date=2010-09-01&rft.volume=110&rft.issue=9&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nursing&rft.issn=0002936X&rft_id=info:doi/10.1097%2F01.NAJ.0000388242.06365.4f LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Legislation DO - http://dx.doi.org/10.1097/01.NAJ.0000388242.06365.4f ER - TY - JOUR T1 - The in silico prediction of human-specific metabolites from hepatotoxic drugs. AN - 755972481; 20843294 AB - In this study we employed the use of the Meteor computational software program to perform predictions in silico on 17 hepatotoxic drugs for determining human-specific drug metabolites. Congruence of the in silico predictions from a qualitative standpoint of drug metabolite structures was established by comparison to human in vivo drug metabolic profiles characterized in publically available clinical studies. A total of 87 human-specific metabolites were identified from the 17 drugs. We found that Meteor's positive predictions included 4 out of the 9 reported major metabolites (detected in excreta at a level of >10% of the administered p.o. dose) and 10 out of the 15 major phase II metabolites giving a total of 14 correctly predicted drug metabolite structures out of 23 major metabolites. A significant level of unconfirmed positive predictions resulted and discussion on reasons for this is presented. An example is given whereby the in silico metabolism prediction succeeded to predict the putative toxic pathway of one of the drugs whilst conventional rodent liver microsomal assays failed to predict the pathway. Overall, we describe a reasonable simulation of human metabolic profiling using this in silico method with this data set of hepatotoxic drugs now withdrawn from the market. We provide an in-depth and objective discussion of this first of its kind validation test using clinical study data with interest in the prediction human-specific metabolism. Further research is discussed on what areas need to be investigated to improve upon the predictive data. The strong potential of this method to predict human-specific drug metabolites suggests the utility of this computational tool to help support not only the discovery development of therapeutics but also the safety assessment in identifying drug metabolites early to protect patients prior to initiating clinical studies. JF - Current drug discovery technologies AU - Valerio, Luis G AU - Long, Anthony AD - Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Luis.Valerio@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 170 EP - 187 VL - 7 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Humans KW - Knowledge Bases KW - Software KW - Pharmaceutical Preparations -- metabolism KW - Computer Simulation KW - Pharmaceutical Preparations -- chemistry KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755972481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+discovery+technologies&rft.atitle=The+in+silico+prediction+of+human-specific+metabolites+from+hepatotoxic+drugs.&rft.au=Valerio%2C+Luis+G%3BLong%2C+Anthony&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-09-01&rft.volume=7&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Current+drug+discovery+technologies&rft.issn=1875-6220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-10 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - FOREWORD AN - 755511290 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755511290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 755509507; 21037592 AB - Androstenedione is a natural androgen steroid hormone that is synthesized in men and women. Commercially it is used as an intermediate in the production of other steroids including oral contraceptives and anti-inflammatory products. Until its over-the-counter sales were banned in 2004, androstenedione was marketed as a supplement to aid athletes in gaining muscle mass. We studied the effects of androstenedione on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited androstenedione dissolved in methylcellulose solutions through a tube directly into the stomach to groups of 50 male and female rats and mice for two years. Male and female rats and male mice received 10, 20, or 50 milligrams of androstenedione per kilogram of body weight each day; female mice received 2, 10, or 50 mg/kg. Control animals received methylcellulose solutions with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. A few adenomas and one carcinoma of the lung were seen in male rats receiving androstenedione and there was a slight increase in the rate of mononuclear cell leukemia in exposed female rats. Male and female mice given androstenedione had marked increases in a variety of liver tumors, including adenomas, carcinomas and hepatoblastomas. There were also increases in the rates of pancreatic islet adenomas in male and female mice. Female rats also had increased rates of hyperplasia of the pancreatic islets and atrophy of the exocrine pancreas. Female mice had very marked increases in the rates of hyperplasia of the clitoral gland, metaplasia in the kidney, and cytoplasmic alteration of the salivary gland. We conclude that androstenedione caused liver cancer and pancreatic islet cancer in male and female mice. The occurrence of lung tumors in male rats and mononuclear cell leukemia in female rats may have been related to androstendione exposure. Increases in nonneoplastic lesions of the pancreas in female rats and of the clitoral gland, kidney, and salivary gland in female mice were attributed to androstenedione exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 31,33-171 passim CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Biological Markers KW - Mutagens KW - Androstenedione KW - Steroids KW - Health hazards KW - Toxicology KW - Animals KW - Chemistry, Pharmaceutical KW - Dose-Response Relationship, Drug KW - Drug-Induced Liver Injury -- pathology KW - Intubation, Gastrointestinal KW - Androstenedione -- pharmacology KW - Mutagens -- toxicity KW - Mice KW - Rats KW - Genitalia -- drug effects KW - Drug-Induced Liver Injury -- metabolism KW - Mice, Inbred Strains KW - Estrous Cycle KW - Rats, Inbred F344 KW - Animal Feed KW - Micronucleus Tests KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Male KW - Female KW - Organ Size -- drug effects KW - Androstenedione -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+ANDROSTENEDIONE+%28CAS+NO.+63-05-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Photographs; References; Diagrams; Graphs; Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 755509466 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Histological and histomorphometrical analyses of biopsies harvested 11 years after maxillary sinus floor augmentation with deproteinized bovine and autogenous bone AN - 754537313; 13246030 AB - Objective: The purpose of the present study was to histologically and histomorphometrically evaluate the long-term tissue response to deproteinized bovine bone (DPBB) particles used in association with autogenous bone and to compare particle size after 6 months and 11 years, in the same patients, in order to determine possible resorption. Material and methods: Twenty consecutive patients (14 women and six men) with a mean age of 62 years (range 48-69 years) with severe atrophy of the posterior maxilla were included in this study. Thirty maxillary sinuses with <5mm subantral alveolar bone were augmented with a mixture of 80% DPBB and 20% autogenous bone. Eleven years (mean 11.5 years) after augmentation, biopsies were taken from the grafted areas of the 11 patients who volunteered to participate in this new surgical intervention. The following histomorphometrical measurements were performed in these specimens: total bone area in percentage, total area of the DPBB, total area of marrow space, the degree of DPBB-bone contact (percentage of the total surface length for each particle), the length of all DPBB particles and the area of all DPBB particles. The length and the area of the particles were compared with samples harvested from the same patients at 6 months (nine samples) and pristine particles from the manufacturer. Results: The biopsies consisted of 44.7 plus or minus 16.9% lamellar bone, 38 plus or minus 16.9% marrow space and 17.3 plus or minus 13.2% DPBB. The degree of DPBB to bone contact was 61.5 plus or minus 34%. There were no statistically significant differences between the length and area of the particles after 11 years compared with those measured after 6 months in the same patients or to pristine particles from the manufacturer. Conclusion: DPBB particles were found to be well integrated in lamellar bone, after sinus floor augmentation in humans, showing no significant changes in particle size after 11 years. JF - Clinical Oral Implants Research AU - Mordenfeld, Arne AU - Hallman, Mats AU - Johansson, Carina B AU - Albrektsson, Tomas AD - 1Department of Oral and Maxillofacial Surgery, Public Health Service, Gaevle, Sweden Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 961 EP - 970 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 21 IS - 9 SN - 0905-7161, 0905-7161 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Dental restorative materials KW - Biopsy KW - Maxillary sinus KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754537313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Oral+Implants+Research&rft.atitle=Histological+and+histomorphometrical+analyses+of+biopsies+harvested+11+years+after+maxillary+sinus+floor+augmentation+with+deproteinized+bovine+and+autogenous+bone&rft.au=Mordenfeld%2C+Arne%3BHallman%2C+Mats%3BJohansson%2C+Carina+B%3BAlbrektsson%2C+Tomas&rft.aulast=Mordenfeld&rft.aufirst=Arne&rft.date=2010-09-01&rft.volume=21&rft.issue=9&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Clinical+Oral+Implants+Research&rft.issn=09057161&rft_id=info:doi/10.1111%2Fj.1600-0501.2010.01939.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Dental restorative materials; Biopsy; Maxillary sinus DO - http://dx.doi.org/10.1111/j.1600-0501.2010.01939.x ER - TY - JOUR T1 - The Role of the Federal Statistical System in Evidence-based Policymaking, or How to Make the Statistical System Essential AN - 754064687; 201050221 AB - This article discusses the strained nature of the relationship between the research/analytic world and the policy/political world. The research/analytic world in general and the statistical community in particular are portrayed as not wanting to be pulled into partisan politics. At the same time, the policy makers are portrayed as not seeing that statistical analysis is essential to confronting difficult real-world decisions. The article points out that there is a fundamental pressure pushing the two together: the federal budget. It shows that over the past decade or two, funding for statistical agencies has been under increasing pressure to show the "return on investment" of the taxpayers' dollars. The article suggests that the way out of this problem is by becoming an essential partner with the policy makers in dealing with the challenging issues that they face by supporting and advancing evidence-based policymaking. [Reprinted by permission of Sage Publications Inc., copyright The American Academy of Political and Social Science.] JF - The Annals of the American Academy of Political and Social Science AU - O'Grady, Michael J AD - National Opinion Research Center at the University of Chicago and the Department of Health and Human Services (HHS) Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 180 EP - 188 PB - Sage Publications, Thousand Oaks CA VL - 631 SN - 0002-7162, 0002-7162 KW - healthcare reform Office of Technology Assessment Health and Human Services KW - Taxation KW - Policy Making KW - Partisanship KW - Budgets KW - Investment KW - Quantitative Methods KW - article KW - 9043: methodology and research technology; research methods and models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754064687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.atitle=The+Role+of+the+Federal+Statistical+System+in+Evidence-based+Policymaking%2C+or+How+to+Make+the+Statistical+System+Essential&rft.au=O%27Grady%2C+Michael+J&rft.aulast=O%27Grady&rft.aufirst=Michael&rft.date=2010-09-01&rft.volume=631&rft.issue=&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.issn=00027162&rft_id=info:doi/10.1177%2F0002716210374154 LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 1 N1 - Last updated - 2016-09-28 N1 - CODEN - AAYPAV N1 - SubjectsTermNotLitGenreText - Policy Making; Quantitative Methods; Investment; Taxation; Partisanship; Budgets DO - http://dx.doi.org/10.1177/0002716210374154 ER - TY - JOUR T1 - The ABC transporter HrtAB confers resistance to hemin toxicity and is regulated in a hemin-dependent manner by the ChrAS two-component system in Corynebacterium diphtheriae. AN - 749001044; 20639324 AB - Corynebacterium diphtheriae, the causative agent of the severe respiratory disease diphtheria, utilizes hemin and hemoglobin as iron sources for growth in iron-depleted environments. Because of the toxicity of high levels of hemin and iron, these compounds are often tightly regulated in bacterial systems. In this report, we identify and characterize the C. diphtheriae hrtAB genes, which encode a putative ABC type transporter involved in conferring resistance to the toxic effects of hemin. Deletion of the hrtAB genes in C. diphtheriae produced increased sensitivity to hemin, which was complemented by a plasmid harboring the cloned hrtAB locus. The HrtAB system was not involved in the uptake and use of hemin as an iron source. The hrtAB genes are located on the C. diphtheriae genome upstream from the chrSA operon, which encodes a previously characterized two-component signal transduction system that regulates gene expression in a heme-dependent manner. The hrtB promoter is activated by the ChrAS system in the presence of hemin or hemoglobin, and mutations in the chrSA genes abolish heme-activated expression from the hrtB promoter. It was also observed that transcription from the hrtB promoter is reduced in a dtxR deletion mutant, suggesting that DtxR is required for optimal expression of hrtAB. Previous studies proposed that the ChrS sensor kinase may be responsive to an environmental signal, such as hemin. We show that specific point mutations in the ChrS N-terminal transmembrane domain result in a reduced ability to activate the hrtB promoter in the presence of a heme source, suggesting that this putative sensor region is essential for the detection of a signal produced in response to hemin exposure. This study shows that the HrtAB system is required for protection from hemin toxicity and that expression of the hrtAB genes is regulated by the ChrAS two-component system. This study demonstrates a direct correlation between the detection of heme or a heme-associated signal by the N-terminal sensor domain of ChrS and the transcriptional activation of the hrtAB genes. JF - Journal of bacteriology AU - Bibb, Lori A AU - Schmitt, Michael P AD - Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 4606 EP - 4617 VL - 192 IS - 18 KW - Bacterial Proteins KW - 0 KW - Hemoglobins KW - Hemin KW - 743LRP9S7N KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Hemoglobins -- metabolism KW - Gene Expression Regulation, Bacterial -- drug effects KW - Promoter Regions, Genetic -- genetics KW - Computational Biology KW - Iron -- metabolism KW - Gene Expression Regulation, Bacterial -- genetics KW - Hemin -- toxicity KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- chemistry KW - Corynebacterium diphtheriae -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Bacterial Proteins -- metabolism KW - ATP-Binding Cassette Transporters -- genetics KW - Corynebacterium diphtheriae -- genetics KW - Corynebacterium diphtheriae -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749001044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=The+ABC+transporter+HrtAB+confers+resistance+to+hemin+toxicity+and+is+regulated+in+a+hemin-dependent+manner+by+the+ChrAS+two-component+system+in+Corynebacterium+diphtheriae.&rft.au=Bibb%2C+Lori+A%3BSchmitt%2C+Michael+P&rft.aulast=Bibb&rft.aufirst=Lori&rft.date=2010-09-01&rft.volume=192&rft.issue=18&rft.spage=4606&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.00525-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-13 N1 - Date created - 2010-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1997 Nov;65(11):4634-41 [9353044] J Mol Biol. 1975 Aug 5;96(2):307-16 [1100846] J Bacteriol. 1999 Sep;181(17):5330-40 [10464204] J Bacteriol. 1954 Feb;67(2):220-32 [13129217] J Bacteriol. 2005 Jan;187(2):422-33 [15629913] J Bacteriol. 2005 Aug;187(16):5658-64 [16077111] Infect Immun. 2005 Nov;73(11):7406-12 [16239540] J Bacteriol. 2006 Apr;188(8):2959-73 [16585757] PLoS Pathog. 2006 Aug;2(8):e87 [16933993] Microbiol Mol Biol Rev. 2006 Dec;70(4):910-38 [17158704] J Bacteriol. 2007 May;189(9):3650-4 [17322319] Infect Immun. 2007 May;75(5):2421-31 [17353293] J Biol Chem. 2007 Sep 7;282(36):26111-21 [17635909] Cell Host Microbe. 2007 Apr 19;1(2):109-19 [18005689] Nucleic Acids Res. 2008 Jan;36(Database issue):D281-8 [18039703] BMC Genomics. 2006;7:21 [16469103] J Biol Chem. 2009 Jan 9;284(2):1166-76 [18984582] J Bacteriol. 2009 Apr;191(8):2638-48 [19201805] Contrib Microbiol. 2009;16:120-35 [19494582] FEBS Lett. 2009 Jul 7;583(13):2244-8 [19505463] Amino Acids. 2009 Sep;37(3):479-86 [19259771] Mol Microbiol. 2009 May;72(3):763-78 [19400785] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] J Bacteriol. 1991 Jul;173(14):4288-96 [2066330] Infect Immun. 1991 Nov;59(11):3903-8 [1718867] Crit Rev Microbiol. 1992;18(3):217-33 [1532495] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7576-80 [1502169] Annu Rev Genet. 1992;26:71-112 [1482126] Gene. 1994 Jul 22;145(1):69-73 [8045426] Mol Microbiol. 1994 Aug;13(4):719-32 [7997183] Mol Microbiol. 1995 Nov;18(3):383-90 [8748023] J Infect Dis. 1996 Nov;174(5):1064-72 [8896510] J Bacteriol. 1997 Feb;179(3):838-45 [9006041] Mol Microbiol. 2000 Apr;36(1):68-84 [10760164] J Bacteriol. 2001 Feb;183(4):1476-81 [11157965] Toxicon. 2001 Nov;39(11):1793-803 [11595641] Mol Microbiol. 2001 Nov;42(3):851-65 [11722747] DNA Cell Biol. 2002 Apr;21(4):281-95 [12042068] Biochem Soc Trans. 2002 Aug;30(4):691-6 [12196166] Microbes Infect. 2002 Sep;4(11):1149-56 [12361915] J Bacteriol. 2002 Dec;184(24):6882-92 [12446639] Nucleic Acids Res. 2003 Nov 15;31(22):6516-23 [14602910] J Bacteriol. 2003 Dec;185(23):6826-40 [14617647] Mol Microbiol. 2003 Nov;50(4):1429-38 [14622427] Contrib Microbiol. 2005;12:210-33 [15496782] J Biol Chem. 1998 Jan 9;273(2):837-41 [9422739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.00525-10 ER - TY - JOUR T1 - Chronic oral treatment with isotretinoin alters measures of activity but not anxiety in male and female rats. AN - 748946674; 20381607 AB - Use of the anti-acne drug, Accutane (ACC) (isotretinoin, 13-cis-retinoic acid), has been associated with neuropsychiatric events ranging from depression in animal models to depression and suicide ideation in humans. Our studies, however, have consistently indicated few effects on measures of depression in male and female rats. Still, the comorbidity of depression and anxiety suggests that anxiety assessments in ACC-treated rats could be informative. Such assessments must be balanced with measures of activity since drug-induced activity alterations may impact the expression of anxiety-like behaviors. Here, Sprague-Dawley rats (n=15/sex/dose) were gavaged daily with 0 (soy oil), 7.5, or 30 mg/kg/day ACC beginning on postnatal day (PND) 59. Blood ACC levels similar to humans taking recommended ACC doses are produced by 7.5mg/kg/day. Short-term activity was assessed in open fields prior to ACC treatment (PND 51) and again at PNDs 129 and 164 and in a complex environment at PNDs 66 and PND 184. Long-term residential activity was measured in running wheels (PNDs 85-92) and figure 8 mazes (PNDs 99-106). Anxiety-like behavior was assessed via elevated plus maze (EPM) activity on PND 98 and in a black/white apparatus on PND 125. The typical sex differences in most behaviors were exhibited (i.e., increased EPM open arm entries and overall activity in most measures in females); however, there were no significant effects of ACC treatment on open field activity, complex environment activity, residential running wheel activity, or EPM activity. Residential figure 8 maze activity indicated that male and female rats treated with 30 mg/kg/day were less active on all nights (p<0.05) and females treated with 7.5 or 30 mg/kg/day were less active than same-sex controls on most days (p<0.05). Similarly, rats of both sexes treated with 30 mg/kg/day were significantly less active in the black/white apparatus (p<0.05), entering the darkened area less frequently (p<0.05), although duration in the darkened area did not differ. These data indicate that at blood levels typically achieved by humans (i.e., the 7.5 mg/kg group), there are no significant anxiogenic effects associated with ACC treatment. At higher ACC levels, there are mild effects on activity but these appear to be apparatus- and/or age-specific. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Berry, Kimberly J AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Sherry.Ferguson@fda.hhs.gov PY - 2010 SP - 573 EP - 578 VL - 32 IS - 5 KW - Teratogens KW - 0 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Adaptation, Physiological -- drug effects KW - Rats, Sprague-Dawley KW - Maze Learning -- drug effects KW - Dose-Response Relationship, Drug KW - Exploratory Behavior -- drug effects KW - Locomotion -- drug effects KW - Male KW - Female KW - Isotretinoin -- administration & dosage KW - Behavior, Animal -- drug effects KW - Sex Characteristics KW - Teratogens -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748946674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Chronic+oral+treatment+with+isotretinoin+alters+measures+of+activity+but+not+anxiety+in+male+and+female+rats.&rft.au=Ferguson%2C+Sherry+A%3BBerry%2C+Kimberly+J&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2010-09-01&rft.volume=32&rft.issue=5&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2010.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-03 N1 - Date created - 2010-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2010.03.009 ER - TY - JOUR T1 - Challenges and opportunities in establishing scientific and regulatory standards for assuring therapeutic equivalence of modified release products: workshop summary report. AN - 733373207; 20440588 AB - Modified release products are complex dosage forms designed to release drug in a controlled manner to achieve desired efficacy and safety. Inappropriate control of drug release from such products may result in reduced efficacy or increased toxicity. This workshop provided an opportunity for pharmaceutical scientists from academia, industry, and regulatory agencies to discuss current industry practices and regulatory expectations for demonstrating pharmaceutical equivalence and bioequivalence of MR products, further facilitating the establishment of regulatory standards for ensuring therapeutic equivalence of these products. JF - The AAPS journal AU - Chen, Mei-Ling AU - Shah, Vinod P AU - Ganes, Derek AU - Midha, Kamal K AU - Caro, James AU - Nambiar, Prabu AU - Rocci, Mario L AU - Thombre, Avinash G AU - Abrahamsson, Bertil AU - Conner, Dale AU - Davit, Barbara AU - Fackler, Paul AU - Farrell, Colm AU - Gupta, Suneel AU - Katz, Russell AU - Mehta, Mehul AU - Preskorn, Sheldon H AU - Sanderink, Gerard AU - Stavchansky, Salomon AU - Temple, Robert AU - Wang, Yaning AU - Winkle, Helen AU - Yu, Lawrence AD - U.S. Food and Drug Administration, Silver Spring, Maryland, USA. meiling.chen@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 371 EP - 377 VL - 12 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Therapeutic Equivalency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733373207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Challenges+and+opportunities+in+establishing+scientific+and+regulatory+standards+for+assuring+therapeutic+equivalence+of+modified+release+products%3A+workshop+summary+report.&rft.au=Chen%2C+Mei-Ling%3BShah%2C+Vinod+P%3BGanes%2C+Derek%3BMidha%2C+Kamal+K%3BCaro%2C+James%3BNambiar%2C+Prabu%3BRocci%2C+Mario+L%3BThombre%2C+Avinash+G%3BAbrahamsson%2C+Bertil%3BConner%2C+Dale%3BDavit%2C+Barbara%3BFackler%2C+Paul%3BFarrell%2C+Colm%3BGupta%2C+Suneel%3BKatz%2C+Russell%3BMehta%2C+Mehul%3BPreskorn%2C+Sheldon+H%3BSanderink%2C+Gerard%3BStavchansky%2C+Salomon%3BTemple%2C+Robert%3BWang%2C+Yaning%3BWinkle%2C+Helen%3BYu%2C+Lawrence&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2010-09-01&rft.volume=12&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-010-9201-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-21 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Psychiatry. 1989 Jul;50(7):256-61 [2500425] Sleep Med. 2006 Aug;7(5):397-406 [16815744] Clin Pharmacol Ther. 1999 Sep;66(3):295-305 [10511066] Psychopharmacol Bull. 1991;27(4):637-43 [1813908] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-010-9201-5 ER - TY - GEN T1 - Original Abbreviated New Animal Drug Applications (ANADAs) AN - 751417119 AB - Two drugs approved under the Original Abbreviated New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Drugs KW - FDA approval KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Original+Abbreviated+New+Animal+Drug+Applications+%28ANADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Original New Animal Drug Applications (NADAs): AN - 751417118 AB - Three drugs approved under the Original New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 38 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Original+New+Animal+Drug+Applications+%28NADAs%29%3A&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - "ENFJ Bichon Frise Seeking ISTP Burmese to Share Home with INTJ Human" AN - 751417117 AB - O'Neill talks about different animal behaviors and personality. Personality preferences may be observed among species and breeds. A Golden retriever rescue organization will advertise their adoptees as kind and fun. Equestrians may describe horses as sympathetic and helpful. JF - FDA Veterinarian AU - O'Neill, Gail Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 6 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Animal behavior KW - Veterinary medicine KW - Veterinarians KW - Preferences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=%22ENFJ+Bichon+Frise+Seeking+ISTP+Burmese+to+Share+Home+with+INTJ+Human%22&rft.au=O%27Neill%2C+Gail&rft.aulast=O%27Neill&rft.aufirst=Gail&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Tables; Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Electronic Adverse Drug Event Reporting Goes Global AN - 751417116 AB - In May 2010, FDA and the National Institutes of Health launched the Safety Reporting Portal, a new Web site that gives consumers and regulated industry a way to electronically report information to the US government. Ultimately, portal users will be able to report a variety of safety and health information, but one of the first uses is for adverse drug event reporting. JF - FDA Veterinarian AU - Scheid, Jon Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 14 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Web sites KW - Information KW - Drug use KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Electronic+Adverse+Drug+Event+Reporting+Goes+Global&rft.au=Scheid%2C+Jon&rft.aulast=Scheid&rft.aufirst=Jon&rft.date=2010-08-16&rft.volume=&rft.issue=557&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Illustrations N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Availability of Vetsulin for Critical Needs Dogs and Cats AN - 751417097 AB - On May 5, 2010, Food and Drug Administration (FDA) announces a plan to address concerns regarding the supply of Intervet/Schering Plough Animal Health's (Intervet) Vetsulin (porcine insulin zinc suspension), a product used to treat diabetes in dogs and cats. FDA is allowing Intervet to offer a limited supply of Vetsulin through their Vetsulin Critical-Need Program and the supply is only to be used for a critical-need dog or cat that, in the medical judgment of the pet's veterinarian, cannot be effectively managed on another insulin product. Further, Intervet continues to work with FDA to address concerns associated with the manufacture of Vetsulin such as the varying amounts of crystalline zinc insulin in the formulation that could cause a delay in insulin action and an overall longer duration of insulin activity. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 29 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Dogs KW - Cats KW - Government agencies KW - Diabetes KW - Veterinary medicine KW - Veterinarians KW - Insulin KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Availability+of+Vetsulin+for+Critical+Needs+Dogs+and+Cats&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA; Intervet-Schering-Plough Animal Health N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - CVM Announces the Availability of the NARMS 2007 Executive Report AN - 751417095 AB - On May 4, 2010, US Food and Drug Administration's Center for Veterinary Medicine (CVM) announces the availability of the National Antimicrobial Resistance Monitoring System -- Enteric Bacteria (NARMS) 2007 Executive Report. The report summarizes, in an integrated format, NARMS data on non-typhoidal Salmonella and Campylobacter isolates recovered in 2007 from food animals at federally inspected plants, retail meats, and humans. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 29 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Drug resistance KW - Gram-negative bacteria KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Announces+the+Availability+of+the+NARMS+2007+Executive+Report&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Riding the Wave - Kudos Roll in for Dr. Reimschuessel AN - 751417065 AB - In Nov 2009, the Board of Publications for the journal, Toxicological Sciences, honored Dr. Renate Reimschuessel and her co-authors with the "Best Paper in Toxicological Sciences" award. A collaborative effort by Dr. Reimschuessel, an FDA scientist at CVM's Office of Research, and scientists at Procter and Gamble, the paper describes the research conducted during the height of the 2007 pet food recall because of melamine contamination. JF - FDA Veterinarian AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 8 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Awards & honors KW - Contamination KW - Toxicity KW - Collaboration KW - Veterinarians KW - Reimschuessel, Renate KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Riding+the+Wave+-+Kudos+Roll+in+for+Dr.+Reimschuessel&rft.au=Stamper%2C+Carmela&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs; References N1 - People - Reimschuessel, Renate N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - All Creatures Great and Small: Properly Medicate Them All AN - 751417062 AB - Kim-Jung talks about medication errors. A medication error can occur anywhere in the medication use process, from a practitioner writing a prescription, to a pharmacist filling the prescription, to a nurse giving the drug to a person in the hospital, or to a person taking the drug at home. JF - FDA Veterinarian AU - Kim-Jung, Linda Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Medical errors KW - Education KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=All+Creatures+Great+and+Small%3A+Properly+Medicate+Them+All&rft.au=Kim-Jung%2C+Linda&rft.aulast=Kim-Jung&rft.aufirst=Linda&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Graphs; Tables N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Evamist Hormone Spray May Cause Illness in Pets AN - 751417059 AB - The Center for Veterinary Medicine would like pet owners to know that Evamist (estradiol transdermal spray), a topical hormone replacement product, sprayed on the forearm to reduce hot flashes in women during menopause, has the potential to cause health problems in pets exposed to the product on the owner's skin. In reported cases, the owners had been applying Evamist spray to their forearms. Secondary exposure to the pets likely occurred when the dogs licked the owner's arms, or while the dog was held by the owner. Small pets (dog, cat, pocket pet) may be especially sensitive to the estrogen in Evamist. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 27 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Estrogen KW - Hormone replacement therapy KW - Animal diseases KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Evamist+Hormone+Spray+May+Cause+Illness+in+Pets&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Spotlight On: Dr. Renate Reimschuessel, Office of Research AN - 751417057 AB - In an interview, Dr. Renate Reimschuessel talks about her interest in aquatic animal medicine, her path to Center for Veterinary Medicine (CVM), her research on melamine, and what her future at CVM holds. JF - FDA Veterinarian AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 10 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinarians KW - Veterinary medicine KW - Aquaculture KW - Reimschuessel, Renate KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Spotlight+On%3A+Dr.+Renate+Reimschuessel%2C+Office+of+Research&rft.au=Stamper%2C+Carmela&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs; References N1 - People - Reimschuessel, Renate N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Ask Dr. Dunham: Thoughts on the Human-Animal Bond - An Interview with CVM Director, Dr. Bernadette Dunham AN - 751417053 AB - In an interview, CVM Director, Dr. Bernadette Dunham talks about humans and animals share an ever-growing bond of care and concern commonly called the "human-animal bond." According to Dr. Dunham, humans share this unique bond with animals because of their unwavering loyalty. JF - FDA Veterinarian AU - Saavedra, Lauren Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 5 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Loyalty KW - Emotions KW - Veterinarians KW - Animal behavior KW - Dunham, Bernadette UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Ask+Dr.+Dunham%3A+Thoughts+on+the+Human-Animal+Bond+-+An+Interview+with+CVM+Director%2C+Dr.+Bernadette+Dunham&rft.au=Saavedra%2C+Lauren&rft.aulast=Saavedra&rft.aufirst=Lauren&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - People - Dunham, Bernadette N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Supplemental New Animal Drug Applications (NADAs) AN - 751417042 AB - Two drugs approved under the Supplemental New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Supplemental+New+Animal+Drug+Applications+%28NADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - CVM Shouts "Hear, Hear!" to Veterinarians around the World AN - 751417040 AB - To honor Claude Bourgelat's legacy and veterinarians worldwide, 2011 has been declared "World Veterinary Year" by 19 countries, including the US. World Veterinary Year, or Vet2011, is a time to raise public awareness about the veterinary profession. JF - FDA Veterinarian AU - Saavedra, Lauren Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 13 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Special events KW - Veterinary medicine KW - Veterinarians KW - Scientists KW - Bourgelat, Claude UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Shouts+%22Hear%2C+Hear%21%22+to+Veterinarians+around+the+World&rft.au=Saavedra%2C+Lauren&rft.aulast=Saavedra&rft.aufirst=Lauren&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - People - Bourgelat, Claude N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA-T.R.A.C.K. AN - 751417039 AB - FDA-Transparency Results Accountability Credibility Knowledge-sharing is a new system used to manage the goals and objectives of program offices in the agency. Launched on April 7, 2010, this new system shows the public how well FDA promotes human and animal health and how well managers use that information to improve FDA's performance. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 15 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Objectives KW - Animal care KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA-T.R.A.C.K.&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Draft Compliance Policy Guide: Salmonella in Animal Feed AN - 751417038 AB - The Food and Drug Administration has published the Notice of Availability of Draft Compliance Policy Guide Section 690.800 Salmonella in Animal Feed in the Federal Register today. The draft CPG, when finalized, will help guide FDA staff's regulatory policy relating to animal feed or feed ingredients that are contaminated with Salmonella and that come in direct contact with humans, such as pet food and pet treats. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Pets KW - Veterinary services KW - Veterinary medicine KW - Salmonella KW - Compliance KW - Food contamination & poisoning KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Draft+Compliance+Policy+Guide%3A+Salmonella+in+Animal+Feed&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - T.A.L.K. Before You Treat AN - 751417036 AB - Steel talks about correctly medicating animals. It requires a proper diagnosis and responsible veterinary treatment. JF - FDA Veterinarian AU - Steel, Ashley AU - McLean, Melanie AU - Greenlees, Kevin AU - Hartogensis, Martine Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 3 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Medical diagnosis KW - Veterinary medicine KW - Medical treatment KW - Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=T.A.L.K.+Before+You+Treat&rft.au=Steel%2C+Ashley%3BMcLean%2C+Melanie%3BGreenlees%2C+Kevin%3BHartogensis%2C+Martine&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Antimicrobial Drugs: Judicious Use Fights Resistance AN - 751417035 AB - The FDA's Center for Veterinary Medicine (CVM) draft guidance entitled "The Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals" is discussed. In the draft guidance, CVM states that using medically important antimicrobial drugs to increase production in food-producing animals is not a judicious use. CVM's draft guidance includes recommendations for the judicious use of antimicrobial drugs in food-producing animals. JF - FDA Veterinarian AU - McLean, Melanie AU - Flynn, William AU - Heinz, Diane Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 16 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary services KW - Antibiotics KW - Livestock KW - Drug resistance KW - Public health KW - Public policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Antimicrobial+Drugs%3A+Judicious+Use+Fights+Resistance&rft.au=McLean%2C+Melanie%3BFlynn%2C+William%3BHeinz%2C+Diane&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces FY 2011 Animal Drug User Fees AN - 751417034 AB - The Food and Drug Administration is publishing a notice in the Federal Register on August 3, 2010, announcing the rates and payment procedures for animal drug user fees for fiscal year (FY) 2011. The Animal Drug User Fee Amendments of 2008 (ADUFA II) reauthorizes FDA to collect user fees for certain animal drug applications, products, establishments, sponsors and investigational animal drug submissions. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Drug use KW - Animals KW - Fiscal years KW - Fees & charges KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+FY+2011+Animal+Drug+User+Fees&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Test Your Minor Species Knowledge with OMUMS! AN - 751417019 AB - McLean presents facts about minor species ferrets and pheasants. The Center for Veterinary Medicine Office of Minor Use and Minor Species Animal Drug Development works hard to make sure safe and effective drugs are available for ferrets and pheasants. Ferrets belong to the weasel family, and Pheasants are not native to North America. JF - FDA Veterinarian AU - McLean, Melanie AU - Oeller, Margaret Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 23 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Wildfowl KW - Mammals KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Test+Your+Minor+Species+Knowledge+with+OMUMS%21&rft.au=McLean%2C+Melanie%3BOeller%2C+Margaret&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OS&C Helps Develop New Electronic Questionnaire for Pet Food Complaints AN - 751417017 AB - In May 2010, FDA launched the Safety Reporting Portal, an electronic portal that allows consumers and regulated industry to report information to FDA. The Center for Veterinary Medicine Office of Surveillance & Compliance played a key part in developing the questionnaire. The electronic questionnaire, which can be accessed through CVM's Web site, gives consumers a new way to report concerns about pet food to FDA. JF - FDA Veterinarian AU - McLean, Melanie AU - Steinberg, Nadine AU - Nguyen, Quynh Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 21 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Pets KW - Feeds KW - Complaints KW - Veterinary medicine KW - Safety KW - Questionnaires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OS%26amp%3BC+Helps+Develop+New+Electronic+Questionnaire+for+Pet+Food+Complaints&rft.au=McLean%2C+Melanie%3BSteinberg%2C+Nadine%3BNguyen%2C+Quynh&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Supplemental Abbreviated New Animal Drug Application (ANADAs) AN - 751417009 AB - Two drugs approved under the Supplemental Abbreviated New Animal Drug Application are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Supplemental+Abbreviated+New+Animal+Drug+Application+%28ANADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Be A.W.A.R.E. AN - 751417008 AB - CVM's brochure entitled Online Pet Pharmacies. Protect Yourself and Your Pets: Be A. W. A. R. E. will be available soon from the Federal Citizen's Information Center (FCIC). When the FCIC is ready to ship orders for this brochure, CVM will issue an update containing all of the ordering information. CVM Updates is available at http://www.fda.gov/AnimalVeterinary/NewsEvents/ CVMUpdates/default.htm. And to access the online version of the A.W.A.R.E. visit http://www.fda.gov/AnimalVeterinary/ResourcesforYou/ AnimalHealthLiteracy/ucm203000.htm. JF - FDA Veterinarian AU - Steel, Ashley Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 17 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Web sites KW - Brochures KW - Prescription drugs KW - Animal care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Be+A.W.A.R.E.&rft.au=Steel%2C+Ashley&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Minor Use/Minor Species Grant Program Request for Applications AN - 751417007 AB - The Food and Drug Administration today announced the publication of a Request for Applications for a grant program to support the development of new animal drugs intended for minor species or minor uses in major species. (Major species are horses, dogs, cats, cattle, pigs, turkeys and chickens.) The grant program was established by the Minor Use and Minor Species Animal Health Act of 2004 and funding was authorized to start after finalization of regulations to implement the Designation provisions of the statute. (Section 573 of the Federal Food, Drug & Cosmetic Act) JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 28 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Grants KW - Veterinary medicine KW - Animals KW - Nonnative species KW - Drugs KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Minor+Use%2FMinor+Species+Grant+Program+Request+for+Applications&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OM, OD, and OS&C Participate in Veterinary Medical Officer Talent Management Advisory Council AN - 751417004 AB - CVM's Office of the Center Director, Office of Surveillance & Compliance, and Office of Management are participating in a government-wide initiative to analyze the federal veterinary workforce and address the needs of this mission-critical occupation. In February 2009, GAO issued two reports stating that the federal government does not sufficiently understand its veterinary workforce and has not adequately identified the needs of this workforce in the event of a national emergency. JF - FDA Veterinarian AU - Cameron AU - Bradbury, Shannon AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 24 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary medicine KW - Veterinarians KW - Talent management KW - Workforce KW - Human resource management KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=OM%2C+OD%2C+and+OS%26amp%3BC+Participate+in+Veterinary+Medical+Officer+Talent+Management+Advisory+Council&rft.au=Cameron%3BBradbury%2C+Shannon%3BStamper%2C+Carmela&rft.aulast=Cameron&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OR on the Cutting-Edge of Research AN - 751416981 AB - The Center for Veterinary Medicine Office of Research is working on several cutting-edge scientific projects with biomarkers. The dairy cow and dairy goat projects, conducted by Dr. Jamie Boehmer, and the swine project, run by Dr. Michael Myers, will provide useful information about the inflammatory process in ruminants and pigs. The herding dog breeds project, conducted by Drs. Michael Myers and Haile Yancy, will provide important animal health information for veterinarians and breeders of herding dogs. JF - FDA Veterinarian AU - Stamper, Carmela AU - Myers, Michael AU - Boehmer, Jamie AU - Yancy, Haile AU - Harbottle, Heather Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 22 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Medical research KW - Biomarkers KW - Animal diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OR+on+the+Cutting-Edge+of+Research&rft.au=Stamper%2C+Carmela%3BMyers%2C+Michael%3BBoehmer%2C+Jamie%3BYancy%2C+Haile%3BHarbottle%2C+Heather&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - What's Happening at CVM?: ONADE Participates in Bioequivalence Workshop AN - 751416975 AB - The Center for Veterinary Medicine's Office of New Animal Drug Evaluation (ONADE) participated in an international workshop on bioequivalence issues in veterinary medicine in Potomac, MD from Jun 27, 2010 to Jun 30, 2010. The workshop was hosted by the American Academy of Veterinary Pharmacology & Therapeutics, European College of Veterinary Pharmacology & Toxicology, and European Association for Veterinary Pharmacology & Toxicology. The recent workshop was described by Dr. Martinez, a pharmacologist in ONADE, as a way to explore creative solutions to the complex bioequivalence issues seen in veterinary medicine. JF - FDA Veterinarian AU - McLean, Melanie AU - Martinez, Marilyn Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 20 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary medicine KW - Drugs KW - Workshops KW - Conferences KW - Animal care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=What%27s+Happening+at+CVM%3F%3A+ONADE+Participates+in+Bioequivalence+Workshop&rft.au=McLean%2C+Melanie%3BMartinez%2C+Marilyn&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Meet the Office of Foods AN - 751416972 AB - On Aug 18, 2009, the Office of Foods (OF) was created by FDA Commissioner Margaret Hamburg to lead a unified FDA Foods program. OF provides leadership, guidance, and support to the FDA Foods Program. The Executive Leadership Team of the FDA Foods Program includes leaders from OF, Center for Food Safety and Applied Nutrition, Center for Veterinary Medicine, Office of Regulatory Affairs, and Office of the Commissioner. JF - FDA Veterinarian AU - O'Neill, Gail AU - McLean, Melanie Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 19 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Food safety KW - Veterinary services KW - Appointments & personnel changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Meet+the+Office+of+Foods&rft.au=O%27Neill%2C+Gail%3BMcLean%2C+Melanie&rft.aulast=O%27Neill&rft.aufirst=Gail&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - GRAS Grows at CVM AN - 751416968 AB - Wong et al talk about the FDA's Center for Veterinary Medicine (CVM) voluntary pilot program that changes the way a company may inform CVM that it has made a GRAS (Generally Recognized As Safe) determination. In CVM's pilot program, a company submits a GRAS notice that summarizes the data and information used to support the GRAS determination for the use of a feed ingredient. If the substance will be used in feed for food-producing animals, like cattle, pigs, and chickens, the GRAS notice addresses human food safety. JF - FDA Veterinarian AU - Wong, Geoffrey AU - Dangin, Alfan AU - McLean, Melanie AU - Korb, Lee Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 18 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Food additives KW - Pilot projects KW - Food safety KW - Feeds KW - Veterinary services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=GRAS+Grows+at+CVM&rft.au=Wong%2C+Geoffrey%3BDangin%2C+Alfan%3BMcLean%2C+Melanie%3BKorb%2C+Lee&rft.aulast=Wong&rft.aufirst=Geoffrey&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - References N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Initiates Rulemaking on Sanitary Food Transportation Act AN - 751416966 AB - On Apr 30, 2010, US Food and Drug Administration's Center for Food Safety and Applied Nutrition (CFSAN) and Center for Veterinary Medicine (CVM) announced an Advance Notice of Proposed Rulemaking (ANPRM) on implementing the Sanitary Food Transportation Act of 2005 (2005 SFTA). The ANPRM is the first step in writing federal regulations that will govern sanitary practices by shippers, carriers by motor vehicle or rail vehicle, receivers, and others engaged in the transportation of food products for humans and animals. The 2005 SFTA also provides broad authority to FDA to regulate the transportation of human and animal food products to protect products from food-safety hazards during transport. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 30 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Federal legislation KW - Food products KW - Food safety KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Initiates+Rulemaking+on+Sanitary+Food+Transportation+Act&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Warns of Salmonella Risk from Frozen Rodents Fed to Reptiles AN - 751416965 AB - The U.S. Food and Drug Administration is warning U.S. and international customers who may have purchased frozen mice from Biggers and Callaham LLC, doing business as MiceDirect, that these products, which are used as food for reptiles, have the potential to be contaminated with Salmonella. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinarians KW - Veterinary medicine KW - Rodents KW - Salmonella KW - Reptiles & amphibians KW - Diet KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Warns+of+Salmonella+Risk+from+Frozen+Rodents+Fed+to+Reptiles&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - JOUR T1 - Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol. AN - 733974161; 20542088 AB - Oxidative stress and secondary excitotoxicity, due to cellular energy deficit, are major factors playing roles in 3-nitropropionic acid (3-NPA) induced mitochondrial dysfunction. Acute or chronic exposure to 3-NPA also leads to neuronal degeneration in different brain regions. The present study quantitatively assessed peripheral neuropathy induced by chronic exposure to 3-NPA in rats. The neuroprotective abilities of two antioxidants, acetyl-l-carnitine and resveratrol, were investigated as well. Rats were exposed for up to four weeks to 3-NPA alone or 3-NPA combined with acetyl-l-carnitine or resveratrol, administered peripherally. The experimental outcome was evaluated by neurophysiological, histological, and morphometric analyses. Rats exposed to 3-NPA developed hind limb paresis. Furthermore, a significant decrease in motor nerve conduction velocity (MCV) was detected in tail nerves and axonal degeneration in sciatic nerves (p<0.05). Treatment with resveratrol prevented the functional effects of 3-NPA exposure, whereas treatment with acetyl-l-carnitine, preventing paresis, was not effective to MCV and morphological changes. These data suggest that resveratrol is a good candidate for treatment of metabolic neuropathy. The experimental outcome of this study shows that chronic treatment with 3-NPA in rats is relevant in development of an experimental model of toxic neuropathy. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Binienda, Zbigniew K AU - Beaudoin, Micheal A AU - Gough, Bobby AU - Ali, Syed F AU - Virmani, Ashraf AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, AR 72079, USA. zbigniew.binienda@fda.hhs.gov Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 117 EP - 121 VL - 480 IS - 2 KW - Antioxidants KW - 0 KW - Environmental Pollutants KW - Neuroprotective Agents KW - Nitro Compounds KW - Propionates KW - Stilbenes KW - Acetylcarnitine KW - 6DH1W9VH8Q KW - resveratrol KW - Q369O8926L KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Index Medicus KW - Rats KW - Axons -- pathology KW - Animals KW - Rats, Sprague-Dawley KW - Axons -- drug effects KW - Neural Conduction -- drug effects KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Sciatic Nerve -- pathology KW - Sciatic Nerve -- physiopathology KW - Sciatic Nerve -- drug effects KW - Male KW - Acetylcarnitine -- therapeutic use KW - Propionates -- toxicity KW - Nitro Compounds -- toxicity KW - Environmental Pollutants -- toxicity KW - Antioxidants -- pharmacology KW - Stilbenes -- pharmacology KW - Peripheral Nervous System Diseases -- pathology KW - Antioxidants -- therapeutic use KW - Stilbenes -- therapeutic use KW - Acetylcarnitine -- pharmacology KW - Neuroprotective Agents -- therapeutic use KW - Peripheral Nervous System Diseases -- drug therapy KW - Peripheral Nervous System Diseases -- chemically induced KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733974161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Assessment+of+3-nitropropionic+acid-evoked+peripheral+neuropathy+in+rats%3A+neuroprotective+effects+of+acetyl-l-carnitine+and+resveratrol.&rft.au=Binienda%2C+Zbigniew+K%3BBeaudoin%2C+Micheal+A%3BGough%2C+Bobby%3BAli%2C+Syed+F%3BVirmani%2C+Ashraf&rft.aulast=Binienda&rft.aufirst=Zbigniew&rft.date=2010-08-16&rft.volume=480&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2010.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-19 N1 - Date created - 2010-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2010.06.020 ER - TY - JOUR T1 - Occupational Trichloroethylene Exposure and Renal Carcinoma Risk: Evidence of Genetic Susceptibility by Reductive Metabolism Gene Variants AN - 877593072; 13651112 AB - Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST) conjugation and bioactivation by renal cysteine b-lyase (CCBL1). We conducted a case-control study in Central Europe (1,097 cases and 1,476 controls) specifically designed to assess risk associated with occupational exposure to TCE through analysis of detailed job histories. All jobs were coded for organic/chlorinated solvent and TCE exposure (ever/never) as well as the frequency and intensity of exposure based on detailed occupational questionnaires, specialized questionnaires, and expert assessments. Increased risk was observed among subjects ever TCE exposed [odds ratio (OR) = 1.63; 95% confidence interval (95% CI), 1.04-2.54]. Exposure-response trends were observed among subjects above and below the median exposure [average intensity (OR = 1.38; 95% CI, 0.81-2.35; OR = 2.34; 95% CI, 1.05-5.21; Ptrend = 0.02)]. A significant association was found among TCE-exposed subjects with at least one intact GSTT1 allele (active genotype; OR = 1.88; 95% CI, 1.06-3.33) but not among subjects with two deleted alleles (null genotype; OR = 0.93; 95% CI, 0.35-2.44; Pinteraction = 0.18). Similar associations for all exposure metrics including average intensity were observed among GSTT1-active subjects (OR = 1.56; 95% CI, 0.79-3.10; OR = 2.77; 95% CI, 1.01-7.58; Ptrend = 0.02) but not among GSTT1 nulls (OR = 0.81; 95% CI, 0.24-2.72; OR = 1.16; 95% CI, 0.27-5.04; Ptrend = 1.00; Pinteraction = 0.34). Further evidence of heterogeneity was seen among TCE-exposed subjects with .1 minor allele of several CCBL1-tagging single nucleotide polymorphisms: rs2293968, rs2280841, rs2259043, and rs941960. These findings provide the strongest evidence to date that TCE exposure is associated with increased renal cancer risk, particularly among individuals carrying polymorphisms in genes that are important in the reductive metabolism of this chemical, and provides biological plausibility of the association in humans. Cancer Res; 70(16); 6527-36. [copy ]2010 AACR. JF - Cancer Research AU - Moore, Lee E AU - Boffetta, Paolo AU - Karami, Sara AU - Brennan, Paul AU - Stewart, Patricia S AU - Hung, Rayjean AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Helena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonila AU - Mates, Dana AU - Gromiec, Jan AU - Holcatova, Ivana AU - Merino, Maria AU - Chanock, Stephen AU - Chow, Wong-Ho AU - Rothman, Nathaniel AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics and Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 6527 EP - 6536 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 70 IS - 16 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts KW - Inventories KW - GSTT1 protein KW - Gene polymorphism KW - Genotoxicity KW - Solvents KW - Carcinogens KW - Glutathione transferase KW - Cancer KW - renal cell carcinoma KW - Cysteine KW - Single-nucleotide polymorphism KW - Dose-response effects KW - Kidney KW - Trichloroethylene KW - Metabolism KW - Occupational exposure KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877593072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Occupational+Trichloroethylene+Exposure+and+Renal+Carcinoma+Risk%3A+Evidence+of+Genetic+Susceptibility+by+Reductive+Metabolism+Gene+Variants&rft.au=Moore%2C+Lee+E%3BBoffetta%2C+Paolo%3BKarami%2C+Sara%3BBrennan%2C+Paul%3BStewart%2C+Patricia+S%3BHung%2C+Rayjean%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Helena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonila%3BMates%2C+Dana%3BGromiec%2C+Jan%3BHolcatova%2C+Ivana%3BMerino%2C+Maria%3BChanock%2C+Stephen%3BChow%2C+Wong-Ho%3BRothman%2C+Nathaniel&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2010-08-15&rft.volume=70&rft.issue=16&rft.spage=6527&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inventories; GSTT1 protein; Gene polymorphism; Genotoxicity; Solvents; Carcinogens; Glutathione transferase; Cancer; renal cell carcinoma; Single-nucleotide polymorphism; Cysteine; Dose-response effects; Kidney; Trichloroethylene; Occupational exposure; Metabolism ER - TY - JOUR T1 - Scombroid poisoning: A review AN - 760207940; 13204119 AB - Scombroid poisoning, also called histamine fish poisoning, is an allergy-like form of food poisoning that continues to be a major problem in seafood safety. The exact role of histamine in scombroid poisoning is not straightforward. Deviations from the expected dose-response have led to the advancement of various possible mechanisms of toxicity, none of them proven. Histamine action levels are used in regulation until more is known about the mechanism of scombroid poisoning. Scombroid poisoning and histamine are correlated but complicated. Victims of scombroid poisoning respond well to antihistamines, and chemical analyses of fish implicated in scombroid poisoning generally reveal elevated levels of histamine. Scombroid poisoning is unique among the seafood toxins since it results from product mishandling rather than contamination from other trophic levels. Inadequate cooling following harvest promotes bacterial histamine production, and can result in outbreaks of scombroid poisoning. Fish with high levels of free histidine, the enzyme substrate converted to histamine by bacterial histidine decarboxylase, are those most often implicated in scombroid poisoning. Laboratory methods and screening methods for detecting histamine are available in abundance, but need to be compared and validated to harmonize testing. Successful field testing, including dockside or on-board testing needed to augment HACCP efforts will have to integrate rapid and simplified detection methods with simplified and rapid sampling and extraction. Otherwise, time-consuming sample preparation reduces the impact of gains in detection speed on the overall analysis time. JF - Toxicon AU - Hungerford, James M AD - ATC, PRL-NW, USFDA, 22201 23rd Dr S.E. Bothell, WA 98021, United States, James.Hungerford@fda.hhs.fda.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 231 EP - 243 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Scombroid poisoning KW - Histamine KW - Scombrotoxin KW - Seafood safety KW - Test kits KW - Dockside testing KW - Histidine decarboxylase KW - Toxicants KW - Abundance KW - Pollution effects KW - Public health KW - Laboratory methods KW - histamines KW - Dose-response effects KW - Sampling KW - Seafood KW - Histamines KW - Screening KW - Antihistamines KW - Poisoning KW - Enzymes KW - Food poisoning KW - Toxicity KW - Food contamination KW - Trophic levels KW - Toxins KW - Literature reviews KW - Reviews KW - Histidine KW - Fish poisoning KW - Fish KW - Chemical analysis KW - Q1 08482:Ecosystems and energetics KW - Q5 08504:Effects on organisms KW - X 24320:Food Additives & Contaminants KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Scombroid+poisoning%3A+A+review&rft.au=Hungerford%2C+James+M&rft.aulast=Hungerford&rft.aufirst=James&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Screening; Literature reviews; Toxicants; Fish poisoning; Pollution effects; Toxicity; Seafood; Histamines; Chemical analysis; Public health; Histidine decarboxylase; Antihistamines; Abundance; Poisoning; Food poisoning; Enzymes; Food contamination; Toxins; Trophic levels; Histamine; Histidine; Reviews; Sampling; Laboratory methods; histamines; Dose-response effects; Fish DO - http://dx.doi.org/10.1016/j.toxicon.2010.02.006 ER - TY - JOUR T1 - Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish AN - 760207546; 13204169 AB - Herein, we describe advancements in monitoring of brevetoxins in molluscan shellfish, with respect to exposure management and control of neurotoxic shellfish poisoning (NSP). Current knowledge of the fate of brevetoxins in molluscan shellfish, and the toxic potency of brevetoxin metabolites, is presented. We review rapid assays for measuring composite brevetoxins, and methodology for measuring constituent brevetoxins, in contaminated shellfish. The applicability of in vitro methods for estimating brevetoxin burden and composite toxicity in shellfish is assessed. Specific and measurable biomarkers of brevetoxin exposure and toxicity in shellfish, and of human intoxication, are described. Their utility in regulatory monitoring of toxic shellfish and in clinical diagnosis of NSP is evaluated. JF - Toxicon AU - Plakas, Steven M AU - Dickey, Robert W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA, Steven.Plakas@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 137 EP - 149 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Brevetoxins KW - Neurotoxic shellfish poisoning KW - Monitoring KW - Shellfish KW - Intoxication KW - Pollution monitoring KW - Poisoning KW - Metabolites KW - Toxicity KW - Biomarkers KW - biomarkers KW - Toxicity tests KW - Bioaccumulation KW - Reviews KW - Neurotoxicity KW - Mollusca KW - Pollution indicators KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08266:Physiology, biochemistry, biophysics KW - X 24370:Natural Toxins KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Advances+in+monitoring+and+toxicity+assessment+of+brevetoxins+in+molluscan+shellfish&rft.au=Plakas%2C+Steven+M%3BDickey%2C+Robert+W&rft.aulast=Plakas&rft.aufirst=Steven&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Bioaccumulation; Shellfish; Biomarkers; Toxicity; Pollution indicators; Toxicity tests; Intoxication; Brevetoxins; Reviews; Neurotoxicity; Poisoning; Metabolites; biomarkers; Mollusca DO - http://dx.doi.org/10.1016/j.toxicon.2009.11.007 ER - TY - JOUR T1 - Ciguatera: A public health perspective AN - 760207022; 13204170 AB - Ciguatera fish poisoning is a seafood-borne illness caused by consumption of fish that have accumulated lipid-soluble ciguatoxins. In the United States, ciguatera is responsible for the highest reported incidence of food-borne illness outbreaks attributed to finfish, and it is reported to hold this distinction globally. Ciguatoxins traverse the marine food web from primary producers, Gambierdiscus spp., to commonly consumed fish in tropical and subtropical regions of the world. Ciguatoxins comprise 12 known congeners among Caribbean and tropical Atlantic fish and 29 reported congeners among Pacific fish. Expanding trade in fisheries from ciguatera-endemic regions contributes to wider distribution and increasing frequency of disease among seafood consumers in non-endemic regions. Ciguatoxins produce a complex array of gastrointestinal, neurological and cardiological symptoms. Treatment options are very limited and supportive in nature. Information derived from the study of ciguatera outbreaks has improved clinical recognition, confirmation, and timely treatment. Such studies are equally important for the differentiation of ciguatoxin profiles in fish from one region to the next, the determination of toxicity thresholds in humans, and the formulation of safety limits. Analytical information from case and outbreak investigations was used to derive Pacific and Caribbean ciguatoxin threshold contamination rates for adverse effects in seafood consumers. To these threshold estimates 10-fold safety factors were applied to address individual human risk factors; uncertainty in the amount of fish consumed; and analytical accuracy. The studies may serve as the basis for industry and consumer advisory levels of 0.10ppb C-CTX-1 equivalent toxicity in fish from the tropical Atlantic, Gulf of Mexico, Caribbean, and 0.01ppb P-CTX-1 equivalent toxicity in fish from Pacific regions. JF - Toxicon AU - Dickey, Robert W AU - Plakas, Steven M AD - U.S. FDA Center for Food Safety and Applied Nutrition, Office of Food Safety, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA, robert.dickey@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 123 EP - 136 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Ciguatera KW - Ciguatoxins KW - Food KW - Threshold limits KW - Disease control KW - Toxicity tests KW - Public health KW - Differentiation KW - ASW, Caribbean Sea KW - Risk factors KW - Fisheries KW - Congeners KW - Consumers KW - Seafood KW - Pollution indicators KW - Food webs KW - Gambierdiscus KW - Poisoning KW - Toxicity KW - Food contamination KW - AS, Tropical Atlantic KW - ASW, Mexico Gulf KW - USA KW - Bioaccumulation KW - Ciguatoxin KW - Side effects KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08484:Species interactions: parasites and diseases KW - X 24320:Food Additives & Contaminants KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Ciguatera%3A+A+public+health+perspective&rft.au=Dickey%2C+Robert+W%3BPlakas%2C+Steven+M&rft.aulast=Dickey&rft.aufirst=Robert&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Bioaccumulation; Disease control; Consumers; Seafood; Ciguatoxin; Pollution indicators; Toxicity tests; Public health; Ciguatera; Food; Threshold limits; Poisoning; Toxicity; Food contamination; Differentiation; Risk factors; Fisheries; Congeners; Side effects; Food webs; Gambierdiscus; ASW, Mexico Gulf; USA; ASW, Caribbean Sea; AS, Tropical Atlantic DO - http://dx.doi.org/10.1016/j.toxicon.2009.09.008 ER - TY - JOUR T1 - Human risk associated with palytoxin exposure AN - 760206999; 13204168 AB - Palytoxin (PTX) was first isolated from the zoanthid Palythoa toxica. Evaluation of PTX toxicity using various animal models determined that PTX was extremely potent through intravenous, intraperitoneal, and intratracheal exposure. PTX was less potent by direct intragastric exposure. PTX also caused significant, non-lethal effects through dermal and ocular exposure. PTX and PTX-like compounds have now been found in additional zoanthid species, red alga, a sea anemone, and several dinoflagellates. PTXs are found throughout certain reef associated food webs, including in fish and crabs responsible for human illness and death. Many of the organisms found to contain PTXs in the environment are also sold in the home aquarium trade, and recent evidence suggests poisonings have occurred through exposure to these organisms. Due to co-occurrence with other seafood toxins, such as ciguatoxins, saxitoxins, and tetrodotoxin, it has been difficult to assess the true risk of PTX poisoning through seafood consumption in humans, but limited cases have been well documented, some involving human fatalities. Recent evidence also suggests that humans are negatively impacted through PTX exposure by inhalation and dermal routes. Continued research into the distribution and occurrence of PTX and PTX-like compounds both in seafood and marine organisms sold in the aquarium trade appears warranted. JF - Toxicon AU - Deeds, Jonathan R AU - Schwartz, Michael D AD - US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 150 EP - 162 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Toxicology Abstracts KW - Palytoxin KW - Seafood poisoning KW - Exposure risks KW - Marine aerosols KW - Aquarium zoanthids KW - Inhalation KW - Reefs KW - Toxicants KW - Animal models KW - Tetrodotoxin KW - Toxicity tests KW - Risks KW - Saxitoxin KW - Dinoflagellates KW - Seafood KW - food webs KW - Trachea KW - Pollution indicators KW - Marine crustaceans KW - Food webs KW - Marine KW - Mortality KW - Intravenous administration KW - Skin KW - Decapoda KW - Crustacea KW - Aquatic plants KW - Poisoning KW - Toxicity KW - Toxins KW - Marine organisms KW - Palythoa toxica KW - Fish KW - Ciguatoxin KW - Q5 08503:Characteristics, behavior and fate KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08482:Ecosystems and energetics KW - P 1000:MARINE POLLUTION KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760206999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Human+risk+associated+with+palytoxin+exposure&rft.au=Deeds%2C+Jonathan+R%3BSchwartz%2C+Michael+D&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Toxicants; Ciguatoxin; Toxicity; Seafood; Marine crustaceans; Pollution indicators; Toxicity tests; Food webs; Risks; Inhalation; Reefs; Intravenous administration; Skin; Poisoning; Animal models; Tetrodotoxin; Toxins; Palytoxin; Dinoflagellates; Saxitoxin; Marine organisms; Trachea; Mortality; Crustacea; Aquatic plants; Fish; food webs; Decapoda; Palythoa toxica; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2009.05.035 ER - TY - JOUR T1 - Paralytic shellfish poisoning: Seafood safety and human health perspectives AN - 760206471; 13204171 AB - Paralytic shellfish poisoning (PSP) is the foodborne illness associated with the consumption of seafood products contaminated with the neurotoxins known collectively as saxitoxins (STXs). This family of neurotoxins binds to voltage-gated sodium channels, thereby attenuating action potentials by preventing the passage of sodium ions across the membrane. Symptoms include tingling, numbness, headaches, weakness and difficulty breathing. Medical treatment is to provide respiratory support, without which the prognosis can be fatal. To protect human health, seafood harvesting bans are in effect when toxins exceed a safe action level (typically 80 mu g STX eq 100 g super(-1) tissue). Though worldwide fatalities have occurred, successful management and monitoring programs have minimized PSP cases and associated deaths. Much is known about the toxin sources, primarily certain dinoflagellate species, and there is extensive information on toxin transfer to traditional vectors - filter-feeding molluscan bivalves. Non-traditional vectors, such as puffer fish and lobster, may also pose a risk. Rapid and reliable detection methods are critical for toxin monitoring in a wide range of matrices, and these methods must be appropriately validated for regulatory purposes. This paper highlights PSP seafood safety concerns, documented human cases, applied detection methods as well as monitoring and management strategies for preventing PSP-contaminated seafood products from entering the food supply. JF - Toxicon AU - Etheridge, Stacey M AD - U.S. FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA, Stacey.etheridge@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 108 EP - 122 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Paralytic shellfish poisoning KW - Saxitoxin KW - Dinoflagellates KW - Seafood KW - Shellfish KW - Puffer fish KW - Lobster KW - Detection methods KW - Monitoring KW - Management KW - Urine KW - Serum KW - Symptoms KW - Sodium channels (voltage-gated) KW - Toxicants KW - Food KW - Respiration KW - Public health KW - Expression vectors KW - Action potential KW - Headache KW - Homarus americanus KW - Mortality KW - Ions KW - Food supply KW - Poisoning KW - Prognosis KW - Toxicity KW - Toxins KW - Sodium KW - Fish KW - Neurotoxins KW - Harvesting KW - Metabolism KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08342:Geographical distribution KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760206471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Paralytic+shellfish+poisoning%3A+Seafood+safety+and+human+health+perspectives&rft.au=Etheridge%2C+Stacey+M&rft.aulast=Etheridge&rft.aufirst=Stacey&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Symptoms; Toxicants; Respiration; Toxicity; Seafood; Neurotoxins; Metabolism; Paralytic shellfish poisoning; Public health; Ions; Sodium channels (voltage-gated); Food; Prognosis; Expression vectors; Action potential; Headache; Dinoflagellates; Saxitoxin; Harvesting; Sodium; Mortality; Food supply; Poisoning; Fish; Shellfish; Toxins; Homarus americanus DO - http://dx.doi.org/10.1016/j.toxicon.2009.12.013 ER - TY - JOUR T1 - Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture AN - 883015431; 15241957 AB - The present study was undertaken to assess, in vitro, the hepatotoxic potential of the food-borne mycotoxin, deoxynivalenol (DON), using rat (Clone9 and MH1C1), mouse (NBL CL2) and human (WRL68 and HepG2) liver cells in culture. The cells were treated with DON for 24 h at 37 degree C in 5% CO2 at concentrations of 0-25 mu g ml-1. Following the treatment period, the cells were assayed for biochemical markers of hepatotoxicity that included three independent cytotoxicity assays, oxidative stress and mitochondrial dysfunction. Concentration-dependent cytotoxicity of DON was observed in each of the five different liver cells derived from three different species (rat, mouse and human) over the entire concentration range studied, beginning at 0.1 mu g ml-1. At these concentrations DON did not induce a biologically significant increase in oxidative stress in these liver cells, and showed a significant decrease in the mitochondrial function only in the rat liver MH1C1 cells compared with the control. The results of this in vitro study suggest that DON is a potential hepatotoxin for the rat, mouse and human liver cells in the concentration range tested in this study. The liver cells used in this study showed distinct endpoint-sensitivity to DON related to the species. Published in 2010 by John Wiley and Sons, Ltd. JF - Journal of Applied Toxicology AU - Sahu, Saura C AU - O'Donnell Jr, Michael W AU - Wiesenfeld, Paddy L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Office of Food Defense, Communication and Emergency Response, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA, saura.sahu@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 566 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 6 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Biochemical markers KW - Biochemistry KW - Hepatocytes KW - Food KW - Mitochondria KW - Cell culture KW - oxidative stress KW - hepatotoxicity KW - Cytotoxicity KW - Mycotoxins KW - Vomitoxin KW - Oxidative stress KW - Liver KW - Carbon dioxide KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - X 24370:Natural Toxins KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Comparative+hepatotoxicity+of+deoxynivalenol+in+rat%2C+mouse+and+human+liver+cells+in+culture&rft.au=Sahu%2C+Saura+C%3BO%27Donnell+Jr%2C+Michael+W%3BWiesenfeld%2C+Paddy+L&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2010-08-01&rft.volume=30&rft.issue=6&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1527 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1527/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Biochemical markers; Mycotoxins; Cytotoxicity; Vomitoxin; Oxidative stress; Hepatocytes; Food; Mitochondria; Cell culture; Carbon dioxide; hepatotoxicity; Biochemistry; Liver; oxidative stress DO - http://dx.doi.org/10.1002/jat.1527 ER - TY - RPRT T1 - Table of contents AN - 878683490 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=547&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDIES) AN - 878683489; 21031005 AB - Ethinyl estradiol is a potent synthetic estrogen that is widely prescribed in oral contraceptives and is also used in the treatment of breast and prostate cancer. Ethinyl estradiol is one of a class of chemicals known as "environmental estrogens" which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats and their offspring were exposed to ethinyl estradiol over the course of four generations. The continuous-breeding study began with groups of 35 Sprague-Dawley rats of each sex exposed to ethinyl estradiol in their feed at concentrations of 2, 10, or 50 parts per billion (ppb). Control animals received the same feed with no ethinyl estradiol added. Animals from the same dose treatment groups were paired and mated, and 25 litters of pups at each exposure concentration (culled to four males and four females each) were continued on study and given feed containing the same concentration of ethinyl estradiol. The process was repeated through a second and third generation, after which the pups were given control feed only, and two more generations were bred in the same manner and given control feed without ethinyl estradiol. Measures of fertility and reproduction were taken for each generation and tissues from the study animals were examined histopathologically. In all three offspring generations the time to vaginal opening (a measure of onset of puberty) was accelerated in females fed 50 ppb ethinyl estradiol. In the first two offspring generations the estrous cycles of the exposed females were prolonged or aberrant prior to mating. Male rats exposed to ethinyl estradiol had increased rates of mammary gland hyperplasia and mineralization of the kidney tubules. We conclude that exposure to trace amounts of ethinyl estradiol in the feed showed clear biological activity in male and female rats, including reduced body weights in both sexes, perturbed estrous cycles in females, and induction of mammary gland hyperplasia and kidney tubule mineralization in males. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 EP - 312 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Ethinyl Estradiol KW - Studies KW - Estrogen KW - Breeding of animals KW - Chemicals KW - Fertility KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Male KW - Female KW - Pregnancy KW - Organ Size -- drug effects KW - Fetus -- drug effects KW - Reproduction -- drug effects KW - Ethinyl Estradiol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+MULTIGENERATIONAL+REPRODUCTIVE+TOXICOLOGY+STUDY+OF+ETHINYL+ESTRADIOL+%28CAS+NO.+57-63-6%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=547&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Document feature - Equations; Tables; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Safety and U.S. Regulatory Considerations in the Nonclinical Use of Medical Ultrasound Devices AN - 853478787; 13714430 AB - Ultrasound imaging has been used for medical purposes for over 50 years and has an excellent safety record. Ultrasonic fetal scanning is generally considered safe and is properly used when medical information on a pregnancy is needed. However, ultrasound energy delivered to the fetus cannot be regarded as completely innocuous. Even though there are no demonstrated risks from ultrasound imaging, it can produce effects on the body. Laboratory studies have demonstrated that diagnostic levels of ultrasound can produce physical effects in tissue, such as mechanical vibrations, rise in temperature and cavitation. A number of in vitro and in vivo (animal and human) biologic effects have been reported following exposure to diagnostic ultrasound devices and low intensity ultrasound used for therapeutic purposes. Most public health experts, clinicians and industry agree that exposure of the fetus to ultrasound for nonmedical purposes should be avoided. The U.S. Food and Drug Administration (FDA) supports this position. JF - Ultrasound in Medicine & Biology AU - Phillips, Robert A AU - Stratmeyer, Mel E AU - Harris, Gerald R AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA, gerald.harris@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1224 EP - 1228 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 36 IS - 8 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Therapeutic applications KW - imaging KW - Fetuses KW - Public health KW - Pregnancy KW - Vibrations KW - Scanning KW - Cavitation KW - Ultrasonics KW - Energy KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853478787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Safety+and+U.S.+Regulatory+Considerations+in+the+Nonclinical+Use+of+Medical+Ultrasound+Devices&rft.au=Phillips%2C+Robert+A%3BStratmeyer%2C+Mel+E%3BHarris%2C+Gerald+R&rft.aulast=Phillips&rft.aufirst=Robert&rft.date=2010-08-01&rft.volume=36&rft.issue=8&rft.spage=1224&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2010.03.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Temperature effects; Vibrations; Cavitation; Scanning; Ultrasonics; Energy; Therapeutic applications; imaging; Ultrasound; Fetuses; Pregnancy; Public health DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2010.03.020 ER - TY - JOUR T1 - Isolation and Identification of Three Thio-sildenafil Analogues in Dietary Supplements AN - 839681421; 14016843 AB - Three compounds were found to have been illegally added to dietary supplements marketed for erectile dysfunction. The structures of these compounds were identified with NMR, HRMS, IR, UV and LC/MS/MS, after comparison with the structure of silde-nafil, data showed that the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom, these thio-sildenafil analogues were identified as thiosildenafil, thiohomosildenafil and hydroxythiohomosildenafil. Since their structures were similar to that of sildenafil, according to structure-activity relationship, the side effects of these analogues might also associate with that of sildenafil. In accordance with this finding, thio-sildenafil analogues have been included in the inspection list of illegal adulterants in Taiwan. From January to October 2009, thiosildenafil was detected in 6 samples, thiohomosildenafil was detected in 4 samples and hydroxythiohomosildenafil was detected in 3 samples. JF - Journal of Food and Drug Analysis AU - Lai, K-C AU - Liu, Y-C AU - Liao, Y-C AU - Lin, Y-L AU - Tsai, L-Y AU - Lin, J-H AU - Lo, C-F AD - Food and Drug Administration, Department of Health, Executive Yuan 161-2, Kuen Yang Street, Nan-kang 115, Taipei, Taiwan, ROC, cflo@fda.gov.tw Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 269 EP - 278 VL - 18 IS - 4 SN - 1021-9498, 1021-9498 KW - Toxicology Abstracts KW - Sulfur KW - Oxygen KW - Data processing KW - Dietary supplements KW - Sildenafil KW - N.M.R. KW - carbonyls KW - Structure-activity relationships KW - Side effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839681421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+and+Drug+Analysis&rft.atitle=Isolation+and+Identification+of+Three+Thio-sildenafil+Analogues+in+Dietary+Supplements&rft.au=Lai%2C+K-C%3BLiu%2C+Y-C%3BLiao%2C+Y-C%3BLin%2C+Y-L%3BTsai%2C+L-Y%3BLin%2C+J-H%3BLo%2C+C-F&rft.aulast=Lai&rft.aufirst=K-C&rft.date=2010-08-01&rft.volume=18&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+and+Drug+Analysis&rft.issn=10219498&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Sulfur; Oxygen; Data processing; Dietary supplements; N.M.R.; Sildenafil; Structure-activity relationships; carbonyls; Side effects ER - TY - JOUR T1 - Effect of media, additives, and incubation conditions on the recovery of high pressure and heat-injured Clostridium botulinum spores AN - 760202020; 13200308 AB - The effect of additives and post-treatment incubation conditions on the recovery of high pressure and heat-injured (i.e., processed at 620MPa and 95 and 100 degree C for 5min) spores of Clostridium botulinum strains, 62-A (proteolytic type A) and 17-B (nonproteolytic type B) was studied. High pressure and heat-injured spores were inoculated into TPGY (Trypticase-Peptone-Glucosea "Yeast extract) anaerobic broth media containing additives (lysozyme, l-alanine, l-aspartic acid, dipicolonic acid, sodium bicarbonate, and sodium lactate) at various concentrations (0-10 mu g/ml) individually or in combination. The spore counts of high pressure and heat-injured 62-A and 17-B recovered from TPGY broth containing lysozyme (10 mu g/ml) incubated for 4 months versus that recovered from peptone-yeast extract-glucose-starch (PYGS) plating agar containing lysozyme (10 mu g/ml) incubated under anaerobic conditions for 5 days were also compared. None of the additives either individually or in combination in TPGY broth improved recovery of injured spore enumeration compared to processed controls without additives. Addition of lysozyme at concentrations of 5 and 10 mu g/ml in TPGY broth improved initial recovery of injured spores of 17-B during the first 4 days of incubation but did not result in additional recovery at the end of the 4 month incubation compared to the processed control without lysozyme. Adding lysozyme at a concentration of 10 mu g/ml to PYGS plating agar resulted in no effect on the recovery of high pressure and heat-injured 62-A and 17-B spores. The recovery counts of high pressure and heat-injured spores of 62-A and 17-B were lower (i.e., <1.0log units) with PYGS plating agar compared to the MPN method using TPGY broth as the growth medium. JF - Food Microbiology AU - Reddy, N R AU - Tetzloff, R C AU - Skinner, GE AD - National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 613 EP - 617 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 27 IS - 5 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clostridium botulinum KW - High pressure processing KW - Recovery of spores KW - Proteolysis KW - Lysozyme KW - Agar KW - Aspartic acid KW - L-Alanine KW - Sodium lactate KW - Spores KW - Pressure KW - Anaerobic conditions KW - Sodium bicarbonate KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760202020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Effect+of+media%2C+additives%2C+and+incubation+conditions+on+the+recovery+of+high+pressure+and+heat-injured+Clostridium+botulinum+spores&rft.au=Reddy%2C+N+R%3BTetzloff%2C+R+C%3BSkinner%2C+GE&rft.aulast=Reddy&rft.aufirst=N&rft.date=2010-08-01&rft.volume=27&rft.issue=5&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2010.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; Agar; Lysozyme; Aspartic acid; L-Alanine; Sodium lactate; Anaerobic conditions; Pressure; Spores; Sodium bicarbonate; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.fm.2010.02.004 ER - TY - JOUR T1 - Characterization of Listeria monocytogenes Recovered from Imported Cheese Contributed to the National PulseNet Database by the U.S. Food and Drug Administration from 2001 to 2008 AN - 759316676; 13703886 AB - Imported foods must meet the same U.S. Food and Drug Administration (FDA) standards as domestic foods. The FDA determines whether an imported food is in compliance with the Federal Food, Drug, and Cosmetic Act. Pursuant to its regulatory activities, the FDA conducts compliance surveillance on imported foods offered for entry into the U.S. commerce. The National PulseNet Database is the molecular surveillance network for foodborne infections and is widely used to provide real-time subtyping support to epidemiologic investigations of foodborne diseases. FDA laboratories use pulsed-field gel electrophoresis to subtype foodborne pathogens recovered from imported foods and submit the molecular patterns to the National PulseNet Database at the Centers for Disease Control and Prevention. There were 60 isolates of Listeria monocytogenes in the FDA Field Accomplishment and Compliance Tracking System from 2001 to 2008 due to cheese imported from the following countries: Mexico (n = 21 isolates), Italy (19), Israel (9), Portugal (5), Colombia (3), Greece (2), and Spain (1). We observed genetic diversity of L. monocytogenes isolates and genetic relatedness among strains recovered from imported cheese products coming to the United States from different countries. Consistent characterization of L. monocytogenes isolates recovered from imported cheeses, accompanied by epidemiologic investigations to ascertain human illness associated with these strains, could be helpful in the control of listeriosis acquired from imported cheeses. JF - Journal of Food Protection AU - Timbo, Babgaleh B AU - Keys, Christine AU - Klontz, Karl AD - Office of Food Defense, Communication and Emergency Response, and 2 Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA, babgaleh.timbo@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1511 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 73 IS - 8 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Portugal KW - Greece KW - Listeriosis KW - Spain KW - Compliance KW - Dairy products KW - Disease control KW - Cosmetics KW - Israel KW - Colombia KW - Cheese KW - Infection KW - food-borne diseases KW - Italy KW - Computer programs KW - prevention KW - Drugs KW - Listeria monocytogenes KW - genetic diversity KW - Pathogens KW - Food contamination KW - Databases KW - USA KW - Mexico KW - FDA KW - Pulsed-field gel electrophoresis KW - J 02310:Genetics & Taxonomy KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Characterization+of+Listeria+monocytogenes+Recovered+from+Imported+Cheese+Contributed+to+the+National+PulseNet+Database+by+the+U.S.+Food+and+Drug+Administration+from+2001+to+2008&rft.au=Timbo%2C+Babgaleh+B%3BKeys%2C+Christine%3BKlontz%2C+Karl&rft.aulast=Timbo&rft.aufirst=Babgaleh&rft.date=2010-08-01&rft.volume=73&rft.issue=8&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 13 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Listeriosis; Pulsed-field gel electrophoresis; Disease control; Cosmetics; Pathogens; Infection; Cheese; Compliance; prevention; Dairy products; FDA; genetic diversity; Food contamination; food-borne diseases; Drugs; Listeria monocytogenes; Portugal; USA; Mexico; Greece; Spain; Israel; Colombia; Italy ER - TY - JOUR T1 - Effect of Exhaled Moisture on Breathing Resistance of N95 Filtering Facepiece Respirators AN - 759313630; 13650200 AB - This study evaluated the effect of exhaled moisture on the breathing resistance of three classes of filtering facepiece respirators (FFR) following 4 h of continuous wear at a breathing volume of 40 l min-1, utilizing an automated breathing and metabolic simulator as a human surrogate. After 4 h, inhalation and exhalation resistance increased by 0.43 and 0.23 mm of H2O pressure, respectively, and average moisture retention in the respirators was 0.26 ml. Under ambient conditions similar to those of the current study, and at similar breathing volumes, it is unlikely that exhaled moisture will add significantly to the breathing resistance of filtering facepiece respirators (FFR) over 4 h of use. JF - Annals of Occupational Hygiene AU - Roberge, Raymond J AU - Bayer, Emily AU - Powell, Jeffrey B AU - Coca, Aitor AU - Roberge, Marc R AU - Benson, Stacey M AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA 15236, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 671 EP - 677 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 6 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Inhalation KW - Respirators KW - Protective equipment KW - wear KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Effect+of+Exhaled+Moisture+on+Breathing+Resistance+of+N95+Filtering+Facepiece+Respirators&rft.au=Roberge%2C+Raymond+J%3BBayer%2C+Emily%3BPowell%2C+Jeffrey+B%3BCoca%2C+Aitor%3BRoberge%2C+Marc+R%3BBenson%2C+Stacey+M&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2010-08-01&rft.volume=54&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inhalation; Respirators; wear; Protective equipment; Occupational health ER - TY - JOUR T1 - Performance of High Flow Rate Samplers for Respirable Particle Collection AN - 759312822; 13650196 AB - The American Conference of Governmental Industrial hygienists (ACGIH) lowered the threshold limit value (TLV) for respirable crystalline silica (RCS) exposure from 0.05 to 0.025 mg m-3 in 2006. For a working environment with an airborne dust concentration near this lowered TLV, the sample collected with current standard respirable aerosol samplers might not provide enough RCS for quantitative analysis. Adopting high flow rate sampling devices for respirable dust containing silica may provide a sufficient amount of RCS to be above the limit of quantification even for samples collected for less than full shift. The performances of three high flow rate respirable samplers (CIP10-R, GK2.69, and FSP10) have been evaluated in this study. Eleven different sizes of monodisperse aerosols of ammonium fluorescein were generated with a vibrating orifice aerosol generator in a calm air chamber in order to determine the sampling efficiency of each sampler. Aluminum oxide particles generated by a fluidized bed aerosol generator were used to test (i) the uniformity of a modified calm air chamber, (ii) the effect of loading on the sampling efficiency, and (iii) the performance of dust collection compared to lower flow rate cyclones in common use in the USA (10-mm nylon and Higgins-Dewell cyclones). The coefficient of variation for eight simultaneous samples in the modified calm air chamber ranged from 1.9 to 6.1% for triplicate measures of three different aerosols. The 50% cutoff size (50dae) of the high flow rate samplers operated at the flow rates recommended by manufacturers were determined as 4.7, 4.1, and 4.8 km for CIP10-R, GK2.69, and FSP10, respectively. The mass concentration ratio of the high flow rate samplers to the low flow rate cyclones decreased with decreasing mass median aerodynamic diameter (MMAD) and high flow rate samplers collected more dust than low flow rate samplers by a range of 2-11 times based on gravimetric analysis. Dust loading inside the high flow rate samplers does not appear to affect the particle separation in either FSP10 or GK2.69. The high flow rate samplers overestimated compared to the International Standards Organization/Comite Europeen de Normalisation/ACGIH respirable convention [up to 40% at large MMAD (27.5 km)] and could provide overestimated exposure data with the current flow rates. However, both cyclones appeared to be able to provide relatively unbiased assessments of RCS when their flow rates were adjusted. JF - Annals of Occupational Hygiene AU - Lee, Taekhee AU - Kim, Seung Won AU - Chisholm, William P AU - Slaven, James AU - Harper, Martin AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 697 EP - 709 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 6 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Aerosols KW - Conferences KW - Quantitative analysis KW - Particulates KW - cyclones KW - Flow rates KW - Dust KW - USA KW - silica KW - Fluidized beds KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759312822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Performance+of+High+Flow+Rate+Samplers+for+Respirable+Particle+Collection&rft.au=Lee%2C+Taekhee%3BKim%2C+Seung+Won%3BChisholm%2C+William+P%3BSlaven%2C+James%3BHarper%2C+Martin&rft.aulast=Lee&rft.aufirst=Taekhee&rft.date=2010-08-01&rft.volume=54&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Aerosols; Conferences; silica; Fluidized beds; Quantitative analysis; Particulates; cyclones; Dust; Flow rates; USA ER - TY - JOUR T1 - Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico AN - 759309889; 13248086 AB - Recent data suggest that prenatal exposure to p,pa super(2)-DDE may reduce height and increase body mass index (BMI) in childhood, thus potentially raising the risk of adult health problems. The association between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7I14g/g lipid. 2633 measurements of height (cm) and weight (kg) were obtained in 2004-2005. The median age of the children during follow-up was 18 months (quartiles 14 and 22 months). Height and body mass index (kg/m2) were age-standardized and expressed as standard deviation scores (SDS). Multivariate random-effect models for longitudinal data were fitted and predicted height and BMI SDS were estimated from the adjusted models. Overall, associations between prenatal DDE level and height or BMI SDS at any given age were not observed. For example, the predicted values showed that children with the highest exposure (DDE: >9.00I14g/g) compared to those least exposed (DDE: <3.01I14g/g) grew similarly and they had a BMI SDS similar to the referent group. The results do not support the prior findings of an association of DDE exposure with childhood height or BMI. JF - Environmental Research AU - Cupul-Uicab, Lea A AU - Hernandez-Avila, Mauricio AU - Terrazas-Medina, Efrain A AU - Pennell, Michael L AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA PY - 2010 SP - 595 EP - 603 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 110 IS - 6 SN - 0013-9351, 0013-9351 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts; Sustainability Science Abstracts KW - Body height KW - Body mass index KW - Child KW - Preschool KW - Growth and development KW - Infant KW - Longitudinal study KW - ppa super(2)-DDE KW - BMI KW - DDE KW - DDT KW - IQR KW - SD KW - SDS KW - Age KW - Prenatal experience KW - Lipids KW - Bone growth KW - Metabolites KW - Models KW - Insecticides KW - Nitrous oxide KW - body mass KW - Data processing KW - Children KW - Birth KW - prenatal experience KW - Mexico KW - Standard deviation KW - Sodium lauryl sulfate KW - Mexico, Chiapas KW - M3 1010:Issues in Sustainable Development KW - R2 23050:Environment KW - H 0500:General KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759309889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Prenatal+exposure+to+the+major+DDT+metabolite+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+growth+in+boys+from+Mexico&rft.au=Cupul-Uicab%2C+Lea+A%3BHernandez-Avila%2C+Mauricio%3BTerrazas-Medina%2C+Efrain+A%3BPennell%2C+Michael+L%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2010-08-01&rft.volume=110&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2010.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Age; Prenatal experience; Data processing; Body height; Lipids; DDE; Bone growth; Metabolites; Children; Models; Birth; Standard deviation; DDT; Sodium lauryl sulfate; Body mass index; prenatal experience; Insecticides; Nitrous oxide; body mass; Mexico; Mexico, Chiapas DO - http://dx.doi.org/10.1016/j.envres.2010.06.001 ER - TY - RPRT T1 - FOREWORD AN - 755511341 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755511341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF GOLDENSEAL ROOT POWDER (HYDRASTIS CANADENSIS) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) AN - 755509520; 21372858 AB - Goldenseal is a plant that has been used in herbal medicine for the treatment of gastrointestinal and urinary disorders and skin, mouth, and eye infections. Extracts of goldenseal root are dried to make teas or liquid extracts or combined with echinacea in tablets. We studied the effects of goldenseal root powder given to rats and mice in the feed to identify potential toxic or cancer-related hazards. We gave feed containing 3,000, 9,000, or 25,000 parts per million (ppm) of goldenseal root powder to groups of 50 male and female rats and mice for two years. Similar groups of animals were given feed with no chemical added and served as the control groups. At the end of the study tissues from more than 40 sites were examined for every animal. Survival of all exposed groups of animals was similar to their controls. The rates of cancer (hepatocellular adenoma) of the liver was markedly increased in male and female rats receiving 25,000 ppm goldenseal root powder, and male mice receiving goldenseal root powder had increased rates of liver hepatoblastomas and multiple hepatocellular adenomas. We conclude that goldenseal root powder caused cancer in the liver of male and female rats and male mice. There was no effect of goldenseal root powder on female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 EP - 188 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Powders KW - Herbal medicine KW - Toxicology KW - Cancer KW - Herbs KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Hydrastis -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GOLDENSEAL+ROOT+POWDER+%28HYDRASTIS+CANADENSIS%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Document feature - Illustrations; References; Graphs; Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 755509435 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Interferon-Lambda: A New Addition to an Old Family AN - 755141395; 13674138 AB - The discovery and initial description of the interferon-l. (IFN-l) family in early 2003 opened an exciting new chapter in the field of IFN research. There are 3 IFN-l genes that encode 3 distinct but highly related proteins denoted IFN-l1, -l2, and -l3. These proteins are also known as interleukin-29 (IL-29), IL-28A, and IL-28B, respectively. Collectively, these 3 cytokines comprise the type III subset of IFNs. They are distinct from both type I and type II IFNs for a number of reasons, including the fact that they signal through a heterodimeric receptor complex that is different from the receptors used by type I or type II IFNs. Although type I IFNs (IFN-a/b) and type III IFNs (IFN-l) signal via distinct receptor complexes, they activate the same intracellular signaling pathway and many of the same biological activities, including antiviral activity, in a wide variety of target cells. Consistent with their antiviral activity, expression of the IFN-l genes and their corresponding proteins is inducible by infection with many types of viruses. Therefore, expression of the type III IFNs (IFN-ls) and their primary biological activity are very similar to the type I IFNs. However, unlike IFN-a receptors which are broadly expressed on most cell types, including leukocytes, IFN-l receptors are largely restricted to cells of epithelial origin. The potential clinical importance of IFN-l as a novel antiviral therapeutic agent is already apparent. In addition, preclinical studies by several groups indicate that IFN-l may also be useful as a potential therapeutic agent for other clinical indications, including certain types of cancer. JF - Journal of Interferon & Cytokine Research AU - Donnelly, R P AU - Kotenko, S V AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Building 29A, Room 3B15, 29 Lincoln Drive, Bethesda, MD 20892, USA, raymond.donnelly@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 555 VL - 30 IS - 8 SN - 1079-9907, 1079-9907 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Interferon KW - Intracellular signalling KW - Leukocytes KW - alpha -Interferon KW - Antiviral activity KW - Infection KW - a-Interferon KW - Cancer KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755141395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Interferon-Lambda%3A+A+New+Addition+to+an+Old+Family&rft.au=Donnelly%2C+R+P%3BKotenko%2C+S+V&rft.aulast=Donnelly&rft.aufirst=R&rft.date=2010-08-01&rft.volume=30&rft.issue=8&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2010.0078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Intracellular signalling; Interferon; alpha -Interferon; Leukocytes; Infection; Antiviral activity; Cancer; a-Interferon DO - http://dx.doi.org/10.1089/jir.2010.0078 ER - TY - JOUR T1 - Low Prevalence of Primary HIV Resistance in Western Massachusetts AN - 755136043; 13638135 AB - Most studies of primary antiretroviral (ARV) resistance have been conducted in large metropolitan areas with reported rates of 8% to 25%. We collected data on 99 HIV-1-infected antiretroviral-naive patients from several sites in Springfield, MA, who underwent genotypic resistance assay between 2004 and 2008. Only major resistance mutations per International AIDS Society-USA (IAS-USA) drug resistance mutations list were considered. The prevalence of resistance was 5% (5 of 99). Three patients had one nonnucleoside reverse transcriptase inhibitor (NNRTI) mutation: 103N, 103N, and 190A, 1 patient had a protease inhibitor (PI) mutation: 90M; and 1 patient had 3-class resistance with NNRTI: 181C, 190A, PI: 90M, and nucleoside analogue reverse transcriptase inhibitor (NRTI): 41L, 210W. Mean time from HIV diagnosis to resistance testing was shorter in patients with resistance versus those without: 9 (range 0.3-42 months) versus 27 (range 0.1-418 months), P = .11. There was a trend to lower mean CD4 count in those with resistance, 170 versus 318 cells/mm super(3), P = .06. No differences were noted in gender, age, HIV risk category, or HIV RNA level. The low prevalence of primary resistance may be explained by differences in demographic and risk factors or may reflect the time from infection to resistance testing. Our findings emphasize the importance of continued resistance surveillance. JF - Journal of the International Association of Physicians in AIDS Care (JIAPAC) AU - Iarikov, Dmitri E AU - Irizarry-Acosta, Melina AU - Martorell, Claudia AU - Hoffman, Robert P AU - Skiest, Daniel J AD - Division of Infectious Diseases, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA, Dmitri.Iarikov@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 227 EP - 231 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 9 IS - 4 SN - 1545-1097, 1545-1097 KW - Virology & AIDS Abstracts; Risk Abstracts KW - HIV KW - primary resistance KW - antiretroviral therapy KW - demography KW - Age KW - Acquired immune deficiency syndrome KW - Drug resistance KW - Infection KW - Demography KW - CD4 antigen KW - Antiviral agents KW - Risk factors KW - infection KW - RNA-directed DNA polymerase KW - metropolitan areas KW - proteinase inhibitors KW - USA, Massachusetts KW - non-nucleoside reverse transcriptase inhibitors KW - Data processing KW - Proteinase inhibitors KW - nucleoside analogs KW - RNA KW - Human immunodeficiency virus KW - Gender KW - USA, Illinois, Springfield KW - drug resistance KW - Mutation KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755136043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.atitle=Low+Prevalence+of+Primary+HIV+Resistance+in+Western+Massachusetts&rft.au=Iarikov%2C+Dmitri+E%3BIrizarry-Acosta%2C+Melina%3BMartorell%2C+Claudia%3BHoffman%2C+Robert+P%3BSkiest%2C+Daniel+J&rft.aulast=Iarikov&rft.aufirst=Dmitri&rft.date=2010-08-01&rft.volume=9&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.issn=15451097&rft_id=info:doi/10.1177%2F1545109710374998 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Number of references - 22 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Age; Data processing; non-nucleoside reverse transcriptase inhibitors; Drug resistance; Proteinase inhibitors; Infection; nucleoside analogs; Demography; CD4 antigen; Antiviral agents; RNA; Risk factors; RNA-directed DNA polymerase; Mutation; demography; proteinase inhibitors; Human immunodeficiency virus; Gender; infection; drug resistance; metropolitan areas; USA, Massachusetts; USA, Illinois, Springfield DO - http://dx.doi.org/10.1177/1545109710374998 ER - TY - JOUR T1 - Evaluation of the Integrated Database Network System (IDNS) SmartGene Software for Analysis of 16S rRNA Gene Sequences for Identification of Nocardia Species AN - 754558998; 13359675 AB - 16S rRNA gene sequences of 102 Nocardia isolates were analyzed using the Integrated Database Network System (IDNS) SmartGene centroid database. A total of 76% of the isolates were correctly identified. Discordant identifications were due to inadequate centroid length (3 species), inaccurate or insufficient entries in the public databases (5 species), and heterogeneous sequences among members of a species (1 species). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Murray, Patrick R AU - Zelazny, Adrian M AD - Microbiology Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, pconville@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 2995 EP - 2998 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 8 SN - 0095-1137, 0095-1137 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Databases KW - Computer programs KW - software KW - Nocardia KW - rRNA 16S KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754558998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+the+Integrated+Database+Network+System+%28IDNS%29+SmartGene+Software+for+Analysis+of+16S+rRNA+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BMurray%2C+Patrick+R%3BZelazny%2C+Adrian+M&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2010-08-01&rft.volume=48&rft.issue=8&rft.spage=2995&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00681-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; software; rRNA 16S; Nocardia DO - http://dx.doi.org/10.1128/JCM.00681-10 ER - TY - JOUR T1 - Improved Molecular Detection of Angiostrongylus cantonensis in Mollusks and Other Environmental Samples with a Species-Specific Internal Transcribed Spacer 1-Based TaqMan Assay AN - 754537297; 13245682 AB - Angiostrongylus cantonensis is the most common cause of human eosinophilic meningitis. Humans become infected by ingesting food items contaminated with third-stage larvae that develop in mollusks. We report the development of a real-time PCR assay for the species-specific identification of A. cantonensis in mollusk tissue. JF - Applied and Environmental Microbiology AU - Qvarnstrom, Yvonne AU - Aramburu da Silva, Ana Cristina AU - Teem, John L AU - Hollingsworth, Robert AU - Bishop, Henry AU - Graeff-Teixeira, Carlos AU - da Silva, Alexandre J AD - Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, abs8@cdc.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 5287 EP - 5289 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Food contamination KW - Spacer KW - Angiostrongylus cantonensis KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754537297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Improved+Molecular+Detection+of+Angiostrongylus+cantonensis+in+Mollusks+and+Other+Environmental+Samples+with+a+Species-Specific+Internal+Transcribed+Spacer+1-Based+TaqMan+Assay&rft.au=Qvarnstrom%2C+Yvonne%3BAramburu+da+Silva%2C+Ana+Cristina%3BTeem%2C+John+L%3BHollingsworth%2C+Robert%3BBishop%2C+Henry%3BGraeff-Teixeira%2C+Carlos%3Bda+Silva%2C+Alexandre+J&rft.aulast=Qvarnstrom&rft.aufirst=Yvonne&rft.date=2010-08-01&rft.volume=76&rft.issue=15&rft.spage=5287&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00546-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Spacer; Angiostrongylus cantonensis DO - http://dx.doi.org/10.1128/AEM.00546-10 ER - TY - JOUR T1 - Parvovirus B19 infection transmitted by transfusion of red blood cells confirmed by molecular analysis of linked donor and recipient samples AN - 754536782; 13247453 AB - Extremely high viremic levels of parvovirus B19 (B19V) can be found in acutely infected, but asymptomatic donors. However, reports of transmission by single-donor blood components are rare. In this prospective study, paired donor-recipient samples were used to investigate the transfusion risk. JF - Transfusion AU - Yu, Mei-ying W AU - Alter, Harvey J AU - Virata-Theimer, Maria Luisa A AU - Geng, Yansheng AU - Ma, Li AU - Schechterly, Cathy A AU - Colvin, Camilla A AU - Luban, Naomi LC AD - From the Division of Hematology, Center for Biologics Evaluation and Research (CBER), FDA, and the Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, Maryland; and the Division of Laboratory Medicine, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1712 EP - 1721 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 8 SN - 0041-1132, 0041-1132 KW - Risk Abstracts KW - Parvovirus B19 KW - infection KW - transfusion KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Parvovirus+B19+infection+transmitted+by+transfusion+of+red+blood+cells+confirmed+by+molecular+analysis+of+linked+donor+and+recipient+samples&rft.au=Yu%2C+Mei-ying+W%3BAlter%2C+Harvey+J%3BVirata-Theimer%2C+Maria+Luisa+A%3BGeng%2C+Yansheng%3BMa%2C+Li%3BSchechterly%2C+Cathy+A%3BColvin%2C+Camilla+A%3BLuban%2C+Naomi+LC&rft.aulast=Yu&rft.aufirst=Mei-ying&rft.date=2010-08-01&rft.volume=50&rft.issue=8&rft.spage=1712&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02591.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - infection; transfusion; Parvovirus B19 DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02591.x ER - TY - JOUR T1 - Consistency of predictive signature genes and classifiers generated using different microarray platforms AN - 754536602; 13243590 AB - Microarray-based classifiers and associated signature genes generated from various platforms are abundantly reported in the literature; however, the utility of the classifiers and signature genes in cross-platform prediction applications remains largely uncertain. As part of the MicroArray Quality Control Phase II (MAQC-II) project, we show in this study 80-90% cross-platform prediction consistency using a large toxicogenomics data set by illustrating that: (1) the signature genes of a classifier generated from one platform can be directly applied to another platform to develop a predictive classifier; (2) a classifier developed using data generated from one platform can accurately predict samples that were profiled using a different platform. The results suggest the potential utility of using published signature genes in cross-platform applications and the possible adoption of the published classifiers for a variety of applications. The study reveals an opportunity for possible translation of biomarkers identified using microarrays to clinically validated non-array gene expression assays. JF - Pharmacogenomics Journal AU - Fan, X AU - Lobenhofer, E K AU - Chen, M AU - Shi, W AU - Huang, J AU - Luo, J AU - Zhang, J AU - Walker, S J AU - Chu, T-M AU - Li, L AU - Wolfinger, R AU - Bao, W AU - Paules, R S AU - Bushel, P R AU - Li, J AU - Shi, T AU - Nikolskaya, T AU - Nikolsky, Y AU - Hong, H AU - Deng, Y AU - Cheng, Y AU - Fang, H AU - Shi, L AU - Tong, W AD - Center for Toxicoinformatics, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 247 EP - 257 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 10 IS - 4 SN - 1470-269X, 1470-269X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Translation KW - Data processing KW - Quality control KW - Adoption KW - DNA microarrays KW - biomarkers KW - G 07880:Human Genetics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics+Journal&rft.atitle=Consistency+of+predictive+signature+genes+and+classifiers+generated+using+different+microarray+platforms&rft.au=Fan%2C+X%3BLobenhofer%2C+E+K%3BChen%2C+M%3BShi%2C+W%3BHuang%2C+J%3BLuo%2C+J%3BZhang%2C+J%3BWalker%2C+S+J%3BChu%2C+T-M%3BLi%2C+L%3BWolfinger%2C+R%3BBao%2C+W%3BPaules%2C+R+S%3BBushel%2C+P+R%3BLi%2C+J%3BShi%2C+T%3BNikolskaya%2C+T%3BNikolsky%2C+Y%3BHong%2C+H%3BDeng%2C+Y%3BCheng%2C+Y%3BFang%2C+H%3BShi%2C+L%3BTong%2C+W&rft.aulast=Fan&rft.aufirst=X&rft.date=2010-08-01&rft.volume=10&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics+Journal&rft.issn=1470269X&rft_id=info:doi/10.1038%2Ftpj.2010.34 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; Quality control; Adoption; biomarkers; DNA microarrays DO - http://dx.doi.org/10.1038/tpj.2010.34 ER - TY - JOUR T1 - Characterization of a gne::IS629 O Rough:H7 Escherichia coli Strain from a Hemorrhagic Colitis Patient AN - 754535416; 13245689 AB - Shiga-toxigenic Escherichia coli strains that are O rough:H7 due to gne::IS629 were thought to be rare and to have unknown pathogenic potential. Recently, an O rough:H7 strain caused by gne::IS629 was isolated from a hemorrhagic colitis patient, suggesting that these strains are pathogenic and may not be as rare as anticipated. JF - Applied and Environmental Microbiology AU - Rump, Lydia V AU - Beutin, Lothar AU - Fischer, Markus AU - Feng, Peter CH AD - Division of Microbiology, Food and Drug Administration, College Park, Maryland 20740, peter.feng@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 5290 EP - 5291 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - Colitis KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754535416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Characterization+of+a+gne%3A%3AIS629+O+Rough%3AH7+Escherichia+coli+Strain+from+a+Hemorrhagic+Colitis+Patient&rft.au=Rump%2C+Lydia+V%3BBeutin%2C+Lothar%3BFischer%2C+Markus%3BFeng%2C+Peter+CH&rft.aulast=Rump&rft.aufirst=Lydia&rft.date=2010-08-01&rft.volume=76&rft.issue=15&rft.spage=5290&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00740-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Colitis; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.00740-10 ER - TY - JOUR T1 - Reactive aggression and functional, not neural, specificity AN - 754135051; 201019961 AB - This article is an author response to Harenski and Kiehl's (2010) commentary on Blair (2010). Adapted from the source document. JF - British Journal of Psychology AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 407 EP - 410 PB - The British Psychological Society, Leicester UK VL - 101 IS - 3 SN - 0007-1269, 0007-1269 KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Psychology&rft.atitle=Reactive+aggression+and+functional%2C+not+neural%2C+specificity&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2010-08-01&rft.volume=101&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Psychology&rft.issn=00071269&rft_id=info:doi/10.1348%2F000712610X512122 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BJSGAE N1 - SubjectsTermNotLitGenreText - Aggression DO - http://dx.doi.org/10.1348/000712610X512122 ER - TY - JOUR T1 - What we know and don't know about the bioeffects of nanoparticles: developing experimental approaches for safety assessment AN - 753675904; 13223444 AB - The Center for Devices and Radiological Health (CDRH) of the US Food and Drug Administration (FDA) regulates nano-based medical products and therefore is required to address the safety and biological effects of nano-scale materials used in these products. Both in vitro and in vivo toxicological research studies are being conducted at the FDA to help determine the risks versus benefits of these new products. This article will briefly summarize some of the initial research findings from FDA-CDRH studies using TiO sub(2), polystyrene, and silicon nanoparticles. JF - Biomedical Microdevices AU - Stratmeyer, Mel E AU - Goering, Peter L AU - Hitchins, Victoria M AU - Umbreit, Thomas H AD - Center for Devices and Radiological Health, Food and Drug Administration, WO64-4078, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 569 EP - 573 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 12 IS - 4 SN - 1387-2176, 1387-2176 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Medical equipment KW - polystyrene KW - nanoparticles KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753675904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Microdevices&rft.atitle=What+we+know+and+don%27t+know+about+the+bioeffects+of+nanoparticles%3A+developing+experimental+approaches+for+safety+assessment&rft.au=Stratmeyer%2C+Mel+E%3BGoering%2C+Peter+L%3BHitchins%2C+Victoria+M%3BUmbreit%2C+Thomas+H&rft.aulast=Stratmeyer&rft.aufirst=Mel&rft.date=2010-08-01&rft.volume=12&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Biomedical+Microdevices&rft.issn=13872176&rft_id=info:doi/10.1007%2Fs10544-008-9261-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Silicon; Medical equipment; polystyrene; nanoparticles DO - http://dx.doi.org/10.1007/s10544-008-9261-9 ER - TY - JOUR T1 - Neurotoxicity of ecstasy (MDMA): an overview. AN - 748930383; 20420572 AB - "Ecstasy" (MDMA) is a powerful hallucinogenic drug which has raised concern worldwide because of its high abuse liability. A plethora of studies have demonstrated that MDMA has the potential to induce neurotoxicity both in human and laboratory animals. Although research on MDMA has been carried out by many different laboratories, the mechanism underlying MDMA induced toxicity has not been fully elucidated. MDMA has the ability to reduce serotonin levels in terminals of axons in the cortex of rats and mice. Recently we have shown that it also has the potential to produce degenerate neurons in discrete areas of the brain such as insular and parietal cortex, thalamus, tenia tecta and bed nucleus of stria terminalis (BST). Acute effects of MDMA can result in a constellation of changes including arrthymias, hypertension, hyperthermia, serotonin (5-HT) syndrome, liver problems, seizures and also long lasting neurocognitive impairments including mood disturbances. In human MDMA abusers, there is evidence for reduction of serotonergic biochemical markers. Several factors may contribute to the MDMA-induced neurotoxicity, especially hyperthermia. Other factors potentially influencing MDMA toxicity include monoamine oxidase metabolism of dopamine and serotonin, nitric oxide generation, glutamate excitotoxicity, serotonin 2A receptor agonism and the formation of MDMA neurotoxic metabolites. In this review we will cover the following topics: pharmacological mechanisms, metabolic pathways and acute effects in laboratory animals, as well as in humans, with special attention on the mechanism and pathology of MDMA induced neurotoxicity. JF - Current pharmaceutical biotechnology AU - Sarkar, Sumit AU - Schmued, Larry AD - Department of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 460 EP - 469 VL - 11 IS - 5 KW - Hallucinogens KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Mice KW - Hallucinogens -- toxicity KW - Brain -- physiopathology KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Nervous System Diseases -- physiopathology KW - Models, Neurological KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748930383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+biotechnology&rft.atitle=Neurotoxicity+of+ecstasy+%28MDMA%29%3A+an+overview.&rft.au=Sarkar%2C+Sumit%3BSchmued%2C+Larry&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2010-08-01&rft.volume=11&rft.issue=5&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+biotechnology&rft.issn=1873-4316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-15 N1 - Date created - 2010-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. AN - 748927244; 20368714 AB - The discordance in results of independent genome-wide association studies (GWAS) indicates the potential for Type I and Type II errors. We assessed the repeatibility of current Affymetrix technologies that support GWAS. Reasonable reproducibility was observed for both raw intensity and the genotypes/copy number variants. We also assessed consistencies between different SNP arrays and between genotype calling algorithms. We observed that the inconsistency in genotypes was generally small at the specimen level. To further examine whether the differences from genotyping and genotype calling are possible sources of variation in GWAS results, an association analysis was applied to compare the associated SNPs. We observed that the inconsistency in genotypes not only propagated to the association analysis, but was amplified in the associated SNPs. Our studies show that inconsistencies between SNP arrays and between genotype calling algorithms are potential sources for the lack of reproducibility in GWAS results. JF - The pharmacogenomics journal AU - Hong, H AU - Shi, L AU - Su, Z AU - Ge, W AU - Jones, W D AU - Czika, W AU - Miclaus, K AU - Lambert, C G AU - Vega, S C AU - Zhang, J AU - Ning, B AU - Liu, J AU - Green, B AU - Xu, L AU - Fang, H AU - Perkins, R AU - Lin, S M AU - Jafari, N AU - Park, K AU - Ahn, T AU - Chierici, M AU - Furlanello, C AU - Zhang, L AU - Wolfinger, R D AU - Goodsaid, F AU - Tong, W AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. huixiao.hong@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 364 EP - 374 VL - 10 IS - 4 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Reproducibility of Results KW - Humans KW - DNA -- genetics KW - Oligonucleotide Array Sequence Analysis -- methods KW - Algorithms KW - Data Interpretation, Statistical KW - Gene Dosage KW - Genotype KW - Haplotypes -- genetics KW - Genome-Wide Association Study -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748927244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=Assessing+sources+of+inconsistencies+in+genotypes+and+their+effects+on+genome-wide+association+studies+with+HapMap+samples.&rft.au=Hong%2C+H%3BShi%2C+L%3BSu%2C+Z%3BGe%2C+W%3BJones%2C+W+D%3BCzika%2C+W%3BMiclaus%2C+K%3BLambert%2C+C+G%3BVega%2C+S+C%3BZhang%2C+J%3BNing%2C+B%3BLiu%2C+J%3BGreen%2C+B%3BXu%2C+L%3BFang%2C+H%3BPerkins%2C+R%3BLin%2C+S+M%3BJafari%2C+N%3BPark%2C+K%3BAhn%2C+T%3BChierici%2C+M%3BFurlanello%2C+C%3BZhang%2C+L%3BWolfinger%2C+R+D%3BGoodsaid%2C+F%3BTong%2C+W&rft.aulast=Hong&rft.aufirst=H&rft.date=2010-08-01&rft.volume=10&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2010.24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2005 Apr 15;308(5720):385-9 [15761122] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Am J Hum Genet. 2006 Feb;78(2):350-6 [16400614] Hum Hered. 2006;61(1):55-64 [16612103] Nat Genet. 2006 Jun;38(6):617-9 [16699517] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Science. 2006 Nov 10;314(5801):989-92 [17053108] Science. 2006 Dec 1;314(5804):1461-3 [17068223] Am J Hum Genet. 2007 Feb;80(2):273-90 [17236132] Nat Genet. 2007 Feb;39(2):207-11 [17200669] Nature. 2007 Feb 22;445(7130):881-5 [17293876] Nat Genet. 2007 May;39(5):645-9 [17401363] Nat Genet. 2007 May;39(5):631-7 [17401366] Nat Genet. 2007 May;39(5):596-604 [17435756] Hum Mol Genet. 2007 Apr 15;16(8):865-73 [17317784] Science. 2007 May 11;316(5826):889-94 [17434869] Nat Genet. 2007 Jun;39(6):770-5 [17460697] Science. 2007 Jun 1;316(5829):1331-6 [17463246] Science. 2007 Jun 1;316(5829):1341-5 [17463248] Science. 2007 Jun 1;316(5829):1336-41 [17463249] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Nat Genet. 2007 Jul;39(7):870-4 [17529973] Nat Genet. 2007 Jul;39(7):857-64 [17554260] Nat Genet. 2007 Jul;39(7):827-9 [17558408] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):989-94 [17618283] Nat Genet. 2007 Aug;39(8):984-8 [17618284] Nat Genet. 2007 Aug;39(8):995-9 [17632509] Nat Genet. 2007 Aug;39(8):1000-6 [17637780] Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52 [17804789] Nature. 2007 Oct 18;449(7164):851-61 [17943122] Am J Hum Genet. 2008 Jan;82(1):160-4 [18179894] Am J Hum Genet. 2008 Feb;82(2):411-23 [18252221] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5 [18245381] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4340-5 [18326623] Nat Rev Genet. 2008 May;9(5):356-69 [18398418] Methods Mol Med. 2008;141:23-35 [18453082] BMC Bioinformatics. 2008;9 Suppl 9:S17 [18793462] Trends Genet. 2001 Sep;17(9):502-10 [11525833] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):505-12 [12050090] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Lancet. 2003 Feb 15;361(9357):598-604 [12598158] Bioinformatics. 2005 May 1;21(9):1958-63 [15657097] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/tpj.2010.24 ER - TY - JOUR T1 - DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential? AN - 734006097; 19783790 AB - DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One of the earliest responses to DNA DSBs is the phosphorylation of a histone, H2AX, at serine 139 (gamma-H2AX), which can be detected by a fluorescent antibody. A study was undertaken to compare the induction of DNA DSBs in normal (small airway epithelial) cells and cancer cells (A549) after exposure to asbestos (crocidolite), a proven carcinogen, silica, a suspected carcinogen, and titanium dioxide (TiO(2)), an inert particle recently reported to be carcinogenic in animals. The results indicate that crocidolite induced greater DNA DSBs than silica and TiO(2), regardless of cell type. DNA DSBs caused by crocidolite were higher in normal cells than in cancer cells. Silica and TiO(2) induced higher DNA DSBs in cancer cells than in normal cells. The production of reactive oxygen species was found to be highest in cells exposed to crocidolite, followed, in potency, by silica and TiO(2). The generation of reactive oxygen species was higher in normal cells than in cancer cells. Cell viability assay indicated that crocidolite caused the greatest cytotoxicity in both cell types. Apoptosis, measured by caspase 3/7 and poly (ADP-Ribose) polymerase activation, was highest in crocidolite-exposed cells, followed by TiO(2) and silica. The results of this study indicate that crocidolite has a greater carcinogenic potential than silica and TiO(2), judged by its ability to cause sustained genomic instability in normal lung cells. JF - American journal of respiratory cell and molecular biology AU - Msiska, Zola AU - Pacurari, Maricica AU - Mishra, Anurag AU - Leonard, Stephen S AU - Castranova, Vince AU - Vallyathan, Val AD - Pathology and Physiology Research Branch, Health Effects Laboratory Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 210 EP - 219 VL - 43 IS - 2 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Reactive Oxygen Species KW - Asbestos KW - 1332-21-4 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - DNA KW - 9007-49-2 KW - Titanium KW - D1JT611TNE KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Carcinogens -- metabolism KW - Enzyme Activation KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Cell Line, Tumor KW - Caspases -- metabolism KW - Cell Survival KW - Silicon Dioxide -- pharmacology KW - Biomarkers, Tumor -- metabolism KW - Titanium -- pharmacology KW - Neoplasms -- chemically induced KW - Asbestos -- pharmacology KW - DNA Breaks, Double-Stranded KW - Neoplasms -- metabolism KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734006097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=DNA+double-strand+breaks+by+asbestos%2C+silica%2C+and+titanium+dioxide%3A+possible+biomarker+of+carcinogenic+potential%3F&rft.au=Msiska%2C+Zola%3BPacurari%2C+Maricica%3BMishra%2C+Anurag%3BLeonard%2C+Stephen+S%3BCastranova%2C+Vince%3BVallyathan%2C+Val&rft.aulast=Msiska&rft.aufirst=Zola&rft.date=2010-08-01&rft.volume=43&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=1535-4989&rft_id=info:doi/10.1165%2Frcmb.2009-0062OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1165/rcmb.2009-0062OC ER - TY - JOUR T1 - Application of nanotechnology in cosmetics. AN - 733630915; 20407919 JF - Pharmaceutical research AU - Mu, Li AU - Sprando, Robert L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. Li.Mu@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 1746 EP - 1749 VL - 27 IS - 8 KW - Cosmetics KW - 0 KW - Dermatologic Agents KW - Index Medicus KW - Risk Factors KW - Humans KW - Dermatologic Agents -- administration & dosage KW - Cosmetics -- chemistry KW - Nanotechnology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733630915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+research&rft.atitle=Application+of+nanotechnology+in+cosmetics.&rft.au=Mu%2C+Li%3BSprando%2C+Robert+L&rft.aulast=Mu&rft.aufirst=Li&rft.date=2010-08-01&rft.volume=27&rft.issue=8&rft.spage=1746&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+research&rft.issn=1573-904X&rft_id=info:doi/10.1007%2Fs11095-010-0139-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-13 N1 - Date created - 2010-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11095-010-0139-1 ER - TY - JOUR T1 - Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure. AN - 733348003; 20340164 AB - Amphetamine (AMPH) is used to treat attention deficit and hyperactivity disorders, but it can produce neurotoxicity and adverse vascular effects at high doses. The endoplasmic reticulum (ER) stress response (ERSR) entails the unfolded protein response, which helps to avoid or minimize ER dysfunction. ERSR is often associated with toxicities resulting from the accumulation of unfolded or misfolded proteins and has been associated with methamphetamine toxicity in the striatum. The present study evaluates the effect of AMPH on several ERSR elements in meninges and associated vasculature (MAV), parietal cortex, and striatum. Adult, male Sprague-Dawley rats were exposed to saline, environmentally induced hyperthermia (EIH) or four consecutive doses of AMPH that produce hyperthermia. Expression changes (mRNA and protein levels) of key ERSR-related genes in MAV, striatum, and parietal cortex at 3 h or 1 day postdosing were monitored. AMPH increased the expression of some ERSR-related genes in all tissues. Atf4 (activating transcription factor 4, an indicator of Perk pathway activation), Hspa5/Grp78 (Glucose regulated protein 78, master regulator of ERSR), Pdia4 (protein disulfide isomerase, protein-folding enzyme), and Nfkb1 (nuclear factor of kappa b, ERSR sensor) mRNA increased significantly in MAV and parietal cortex 3 h after AMPH. In striatum, Atf4 and Hspa5/Grp78 mRNA significantly increased 3 h after AMPH, but Pdia4 and Nfkb11 did not. Thus, AMPH caused a robust activation of the Perk pathway in all tissues, but significant Ire1 pathway activation occurred only after AMPH treatment in the parietal cortex and striatum. Ddit3/Chop, a downstream effector of the ERSR pathway related to the neurotoxicity, was only increased in striatum and parietal cortex. Conversely, Pdia4, an enzyme protective in the ERSR, was only increased in MAV. The overall ERSR manifestation varied significantly between MAV, striatum, and parietal cortex after a neurotoxic exposure to AMPH. JF - Synapse (New York, N.Y.) AU - Thomas, Monzy AU - George, Nysia I AU - Saini, Upasana T AU - Patterson, Tucker A AU - Hanig, Joseph P AU - Bowyer, John F AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 579 EP - 593 VL - 64 IS - 8 KW - Neurotoxins KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Time Factors KW - Neurotoxins -- toxicity KW - Male KW - Stress, Physiological -- physiology KW - Amphetamine -- toxicity KW - Cerebrovascular Circulation -- drug effects KW - Cerebrovascular Circulation -- physiology KW - Meninges -- blood supply KW - Endoplasmic Reticulum -- pathology KW - Meninges -- drug effects KW - Stress, Physiological -- drug effects KW - Corpus Striatum -- blood supply KW - Parietal Lobe -- blood supply KW - Meninges -- physiopathology KW - Corpus Striatum -- physiopathology KW - Endoplasmic Reticulum -- physiology KW - Corpus Striatum -- drug effects KW - Parietal Lobe -- physiopathology KW - Parietal Lobe -- drug effects KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733348003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Endoplasmic+reticulum+stress+responses+differ+in+meninges+and+associated+vasculature%2C+striatum%2C+and+parietal+cortex+after+a+neurotoxic+amphetamine+exposure.&rft.au=Thomas%2C+Monzy%3BGeorge%2C+Nysia+I%3BSaini%2C+Upasana+T%3BPatterson%2C+Tucker+A%3BHanig%2C+Joseph+P%3BBowyer%2C+John+F&rft.aulast=Thomas&rft.aufirst=Monzy&rft.date=2010-08-01&rft.volume=64&rft.issue=8&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=1098-2396&rft_id=info:doi/10.1002%2Fsyn.20763 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-26 N1 - Date created - 2010-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/syn.20763 ER - TY - JOUR T1 - Occupational exposure limits for nanomaterials: state of the art AN - 1434016870; 18523680 AB - Assessing the need for and effectiveness of controlling airborne exposures to engineered nanomaterials in the workplace is difficult in the absence of occupational exposure limits (OELs). At present, there are practically no OELs specific to nanomaterials that have been adopted or promulgated by authoritative standards and guidance organizations. The vast heterogeneity of nanomaterials limits the number of specific OELs that are likely to be developed in the near future, but OELs could be developed more expeditiously for nanomaterials by applying dose-response data generated from animal studies for specific nanoparticles across categories of nanomaterials with similar properties and modes of action. This article reviews the history, context, and approaches for developing OELs for particles in general and nanoparticles in particular. Examples of approaches for developing OELs for titanium dioxide and carbon nanotubes are presented and interim OELs from various organizations for some nanomaterials are discussed. When adequate dose-response data are available in animals or humans, quantitative risk assessment methods can provide estimates of adverse health risk of nanomaterials in workers and, in conjunction with workplace exposure and control data, provide a basis for determining appropriate exposure limits. In the absence of adequate quantitative data, qualitative approaches to hazard assessment, exposure control, and safe work practices are prudent measures to reduce hazards in workers. JF - Journal of Nanoparticle Research AU - Schulte, P A AU - Murashov, V AU - Zumwalde, R AU - Kuempel, ED AU - Geraci, CL AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH, 45226, USA, PSchulte@cdc.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1971 EP - 1987 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 12 IS - 6 SN - 1388-0764, 1388-0764 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Health risks KW - Historical account KW - Titanium dioxide KW - Dose-response effects KW - Reviews KW - Particulates KW - Occupational exposure KW - Nanotechnology KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434016870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanoparticle+Research&rft.atitle=Occupational+exposure+limits+for+nanomaterials%3A+state+of+the+art&rft.au=Schulte%2C+P+A%3BMurashov%2C+V%3BZumwalde%2C+R%3BKuempel%2C+ED%3BGeraci%2C+CL&rft.aulast=Schulte&rft.aufirst=P&rft.date=2010-08-01&rft.volume=12&rft.issue=6&rft.spage=1971&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanoparticle+Research&rft.issn=13880764&rft_id=info:doi/10.1007%2Fs11051-010-0008-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Risk assessment; Historical account; Health risks; Titanium dioxide; Reviews; Dose-response effects; Particulates; Occupational exposure; Nanotechnology DO - http://dx.doi.org/10.1007/s11051-010-0008-1 ER - TY - JOUR T1 - Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine. AN - 733985876; 20510887 AB - The goal of this study was twofold: (a) to search for possible interactive effects between two common drugs of abuse, ethanol and methamphetamine. b) To inquire whether any effects of ethanol could be replicated using an equivalent amount of ethanol in the form of red wine. Adult male C57/6N mice received 2% ethanol for 8 weeks in drinking water or red wine diluted to yield the same ethanol content. On the 9th week animals received multiple injections of methamphetamine (4 x 10 mg/kg, ip, every 2 h). They were then sacrificed 72 h after treatment. Methamphetamine produced a significant depletion of dopamine and DOPAC in the striatum. Treatment with both ethanol and methamphetamine led to a reduction of striatal dopamine and DOPAC that were both non-significantly greater than that observed with methamphetamine alone. Alcohol alone produced no changes in the striatal content of dopamine or its metabolite, DOPAC. These data suggest that low doses of alcohol potentiate methamphetamine-induced neurotoxicity in mice and that this combination may be especially detrimental to the brain. However, an equivalent dose of ethanol in the form of red wine actually partially protected against methamphetamine-induced depletion of dopamine and DOPAC in red wine treated mice. This implies the presence of other agents in red wine, which may mitigate the toxicity of methamphetamine. Copyright 2010 Elsevier B.V. All rights reserved. JF - Brain research AU - Ali, Syed F AU - Bondy, S C AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502, USA. Y1 - 2010/07/30/ PY - 2010 DA - 2010 Jul 30 SP - 247 EP - 250 VL - 1346 KW - Central Nervous System Depressants KW - 0 KW - Central Nervous System Stimulants KW - Neuroprotective Agents KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Ethanol KW - 3K9958V90M KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Brain Chemistry -- drug effects KW - Mice, Inbred C57BL KW - Dopamine -- metabolism KW - Mice KW - Male KW - Chromatography, High Pressure Liquid KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Central Nervous System Stimulants -- toxicity KW - Neurotoxicity Syndromes -- prevention & control KW - Central Nervous System Stimulants -- antagonists & inhibitors KW - Methamphetamine -- antagonists & inhibitors KW - Wine KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733985876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Red+wine+but+not+ethanol+at+low+doses+can+protect+against+the+toxicity+of+methamphetamine.&rft.au=Ali%2C+Syed+F%3BBondy%2C+S+C&rft.aulast=Ali&rft.aufirst=Syed&rft.date=2010-07-30&rft.volume=1346&rft.issue=&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2010.05.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-19 N1 - Date created - 2010-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2010.05.058 ER - TY - CPAPER T1 - Self-perception of Weight and Health and Dietary Quality T2 - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AN - 1312931792; 6017900 JF - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AU - Lin, Chung-Tung AU - Lee, Jonq-Ying Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Diets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.atitle=Self-perception+of+Weight+and+Health+and+Dietary+Quality&rft.au=Lin%2C+Chung-Tung%3BLee%2C+Jonq-Ying&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaea.org/2010am/Posters.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Discovery of a Selective Chk1 Inhibitor for the Treatment of Cancer T2 - 2010 Gordon Research Conference on Natural Products AN - 1312916033; 6010148 JF - 2010 Gordon Research Conference on Natural Products AU - Barda, David Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Cancer KW - CHK1 protein KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312916033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Natural+Products&rft.atitle=Discovery+of+a+Selective+Chk1+Inhibitor+for+the+Treatment+of+Cancer&rft.au=Barda%2C+David&rft.aulast=Barda&rft.aufirst=David&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Natural+Products&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=natproduct LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Influences of Labeling Policy and Media Coverage on the Demand for Butter and Margarine T2 - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AN - 1312885820; 6017393 JF - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AU - Lin, Chung-Tung AU - Lee, Jonq-Ying Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Margarine KW - Butter KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312885820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.atitle=Influences+of+Labeling+Policy+and+Media+Coverage+on+the+Demand+for+Butter+and+Margarine&rft.au=Lin%2C+Chung-Tung%3BLee%2C+Jonq-Ying&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaea.org/2010am/Concurrent_Sessions.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cooperative interactions at the SLP-76 complex are critical for actin polymerization AN - 645277485; 20562827 AB - T-cell antigen receptor (TCR) engagement induces formation of multi-protein signalling complexes essential for regulating T-cell functions. Generation of a complex of SLP-76, Nck and VAV1 is crucial for regulation of the actin machinery. We define the composition, stoichiometry and specificity of interactions in the SLP-76, Nck and VAV1 complex. Our data reveal that this complex can contain one SLP-76 molecule, two Nck and two VAV1 molecules. A direct interaction between Nck and VAV1 is mediated by binding between the C-terminal SH3 domain of Nck and the VAV1 N-terminal SH3 domain. Disruption of the VAV1:Nck interaction deleteriously affected actin polymerization. These novel findings shed new light on the mechanism of actin polymerization after T-cell activation. [PUBLICATION ABSTRACT] JF - EMBO Journal AU - Barda-saad, Mira AU - Shirasu, Naoto AU - Pauker, Maor H AU - Hassan, Nirit AU - Perl, Orly AU - Balbo, Andrea AU - Yamaguchi, Hiroshi AU - Houtman, Jon C D AU - Appella, Ettore AU - Schuck, Peter AU - Samelson, Lawrence E Y1 - 2010/07/21/ PY - 2010 DA - 2010 Jul 21 SP - 2315 EP - 28 CY - Heidelberg PB - Blackwell Publishing Ltd. VL - 29 IS - 14 SN - 02614189 KW - Biology--Cytology And Histology KW - Actins KW - Adaptor Proteins, Signal Transducing KW - Nck protein KW - Oncogene Proteins KW - Phosphoproteins KW - Proto-Oncogene Proteins c-vav KW - Receptors, Antigen, T-Cell KW - Recombinant Fusion Proteins KW - SLP-76 signal Transducing adaptor proteins KW - VAV1 protein, human KW - Antigens KW - Lymphocytes KW - Signal transduction KW - Molecular biology KW - Immune system KW - Cellular biology KW - Gene expression KW - Animals KW - T-Lymphocytes -- cytology KW - Phosphoproteins -- genetics KW - Humans KW - Jurkat Cells KW - Receptors, Antigen, T-Cell -- metabolism KW - Oncogene Proteins -- genetics KW - Protein Binding KW - src Homology Domains KW - Lymphocyte Activation KW - Recombinant Fusion Proteins -- metabolism KW - T-Lymphocytes -- metabolism KW - Proto-Oncogene Proteins c-vav -- genetics KW - Recombinant Fusion Proteins -- genetics KW - Adaptor Proteins, Signal Transducing -- genetics KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Signal Transduction -- physiology KW - Proto-Oncogene Proteins c-vav -- metabolism KW - Actins -- metabolism KW - Oncogene Proteins -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/645277485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Cooperative+interactions+at+the+SLP-76+complex+are+critical+for+actin+polymerization&rft.au=Barda-saad%2C+Mira%3BShirasu%2C+Naoto%3BPauker%2C+Maor+H%3BHassan%2C+Nirit%3BPerl%2C+Orly%3BBalbo%2C+Andrea%3BYamaguchi%2C+Hiroshi%3BHoutman%2C+Jon+C+D%3BAppella%2C+Ettore%3BSchuck%2C+Peter%3BSamelson%2C+Lawrence+E&rft.aulast=Barda-saad&rft.aufirst=Mira&rft.date=2010-07-21&rft.volume=29&rft.issue=14&rft.spage=2315&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Femboj.2010.133 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Jul 21, 2010 N1 - Document feature - References N1 - Last updated - 2014-07-19 N1 - CODEN - EMJODG DO - http://dx.doi.org/10.1038/emboj.2010.133 ER - TY - JOUR T1 - Vibrio cholerae Hemolysin Is Required for Lethality, Developmental Delay, and Intestinal Vacuolation in Caenorhabditis elegans AN - 754554651; 13317033 AB - Cholera toxin (CT) and toxin-co-regulated pili (TCP) are the major virulence factors of Vibrio cholerae O1 and O139 strains that contribute to the pathogenesis of disease during devastating cholera pandemics. However, CT and TCP negative V. cholerae strains are still able to cause severe diarrheal disease in humans through mechanisms that are not well understood. To determine the role of other virulence factors in V. cholerae pathogenesis, we used a CT and TCP independent infection model in the nematode Caenorhabditis elegans and identified the hemolysin A (hlyA) gene as a factor responsible for animal death and developmental delay. We demonstrated a correlation between the severity of infection in the nematode and the level of hemolytic activity in the V. cholerae biotypes. At the cellular level, V. cholerae infection induces formation of vacuoles in the intestinal cells in a hlyA dependent manner, consistent with the previous in vitro observations. Our data strongly suggest that HlyA is a virulence factor in C. elegans infection leading to lethality and developmental delay presumably through intestinal cytopathic changes. JF - PLoS ONE AU - Cinar, Hediye Nese AU - Kothary, Mahendra AU - Datta, Atin R AU - Tall, Ben D AU - Sprando, Robert AU - Bilecen, Kivanc AU - Yildiz, Fitnat AU - McCardell, Barbara AD - Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland, United States of America Y1 - 2010/07/13/ PY - 2010 DA - 2010 Jul 13 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 7 KW - Microbiology Abstracts B: Bacteriology KW - Biotypes KW - Data processing KW - Diarrhea KW - virulence factors KW - Infection KW - Vibrio cholerae KW - pandemics KW - hlyA gene KW - Lethality KW - Pili KW - Cholera toxin KW - Caenorhabditis elegans KW - Vacuoles KW - Intestine KW - Cholera KW - Hemolysins KW - Nematoda KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754554651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Vibrio+cholerae+Hemolysin+Is+Required+for+Lethality%2C+Developmental+Delay%2C+and+Intestinal+Vacuolation+in+Caenorhabditis+elegans&rft.au=Cinar%2C+Hediye+Nese%3BKothary%2C+Mahendra%3BDatta%2C+Atin+R%3BTall%2C+Ben+D%3BSprando%2C+Robert%3BBilecen%2C+Kivanc%3BYildiz%2C+Fitnat%3BMcCardell%2C+Barbara&rft.aulast=Cinar&rft.aufirst=Hediye&rft.date=2010-07-13&rft.volume=5&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011558 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Diarrhea; Data processing; Biotypes; virulence factors; Infection; pandemics; Lethality; hlyA gene; Cholera toxin; Pili; Vacuoles; Intestine; Cholera; Hemolysins; Vibrio cholerae; Caenorhabditis elegans; Nematoda DO - http://dx.doi.org/10.1371/journal.pone.0011558 ER - TY - JOUR T1 - Properly Folded Bacterially Expressed H1N1 Hemagglutinin Globular Head and Ectodomain Vaccines Protect Ferrets against H1N1 Pandemic Influenza Virus AN - 754552039; 13315681 AB - In the face of impending influenza pandemic, a rapid vaccine production and mass vaccination is the most effective approach to prevent the large scale mortality and morbidity that was associated with the 1918 "Spanish Flu". The traditional process of influenza vaccine production in eggs is time consuming and may not meet the demands of rapid global vaccination required to curtail influenza pandemic. Recombinant technology can be used to express the hemagglutinin (HA) of the emerging new influenza strain in a variety of systems including mammalian, insect, and bacterial cells. In this study, two forms of HA proteins derived from the currently circulating novel H1N1 A/California/07/2009 virus, HA1 (1-330) and HA (1-480), were expressed and purified from E. coli under controlled redox refolding conditions that favoured proper protein folding. However, only the recombinant HA1 (1-330) protein formed oligomers, including functional trimers that bound receptor and caused agglutination of human red blood cells. These proteins were used to vaccinate ferrets prior to challenge with the A/California/07/2009 virus. Both proteins induced neutralizing antibodies, and reduced viral loads in nasal washes. However, the HA1 (1-330) protein that had higher content of multimeric forms provided better protection from fever and weight loss at a lower vaccine dose compared with HA (1-480). Protein yield for the HA1 (1-330) ranged around 40 mg/Liter, while the HA (1-480) yield was 0.4-0.8 mg/Liter. This is the first study that describes production in bacterial system of properly folded functional globular HA1 domain trimers, lacking the HA2 transmembrane protein, that elicit potent neutralizing antibody responses following vaccination and protect ferrets from in vivo challenge. The combination of bacterial expression system with established quality control methods could provide a mechanism for rapid large scale production of influenza vaccines in the face of influenza pandemic threat. JF - PLoS ONE AU - Khurana, Surender AU - Verma, Swati AU - Verma, Nitin AU - Crevar, Corey J AU - Carter, Donald M AU - Manischewitz, Jody AU - King, Lisa R AU - Ross, Ted M AU - Golding, Hana AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America Y1 - 2010/07/12/ PY - 2010 DA - 2010 Jul 12 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 7 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agglutination KW - Antibodies KW - Eggs KW - Erythrocytes KW - Fever KW - HA protein KW - Hemagglutinins KW - Influenza KW - Membrane proteins KW - Morbidity KW - Mortality KW - Protein folding KW - Quality control KW - Vaccines KW - pandemics KW - Influenza virus KW - Mustela KW - Escherichia coli KW - V 22410:Animal Diseases KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754552039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Properly+Folded+Bacterially+Expressed+H1N1+Hemagglutinin+Globular+Head+and+Ectodomain+Vaccines+Protect+Ferrets+against+H1N1+Pandemic+Influenza+Virus&rft.au=Khurana%2C+Surender%3BVerma%2C+Swati%3BVerma%2C+Nitin%3BCrevar%2C+Corey+J%3BCarter%2C+Donald+M%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BRoss%2C+Ted+M%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2010-07-12&rft.volume=5&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011548 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Mortality; HA protein; Hemagglutinins; Erythrocytes; Membrane proteins; Morbidity; Eggs; Influenza; Fever; pandemics; Antibodies; Agglutination; Protein folding; Quality control; Vaccines; Influenza virus; Mustela; Escherichia coli DO - http://dx.doi.org/10.1371/journal.pone.0011548 ER - TY - CPAPER T1 - Applications of Non-Invasive Optical Methods to Activate Photodynamic Drugs Within Deep Seated Target T2 - 3rd Conference on Light Activated Tissue Regeneration and Therapy AN - 1312918870; 5997776 JF - 3rd Conference on Light Activated Tissue Regeneration and Therapy AU - Waynant, Ronald Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312918870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Conference+on+Light+Activated+Tissue+Regeneration+and+Therapy&rft.atitle=Applications+of+Non-Invasive+Optical+Methods+to+Activate+Photodynamic+Drugs+Within+Deep+Seated+Target&rft.au=Waynant%2C+Ronald&rft.aulast=Waynant&rft.aufirst=Ronald&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Conference+on+Light+Activated+Tissue+Regeneration+and+Therapy&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10atfin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Activity and viability of lactic acid bacteria in yogurts fortified with predigested non-germinated or germinated whole soy powder T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312866625; 5994036 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Nsofor, U AU - Ustunol, Z Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Yogurt KW - Powder KW - Soybeans KW - Lactic acid bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312866625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Activity+and+viability+of+lactic+acid+bacteria+in+yogurts+fortified+with+predigested+non-germinated+or+germinated+whole+soy+powder&rft.au=Nsofor%2C+U%3BUstunol%2C+Z&rft.aulast=Nsofor&rft.aufirst=U&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of a PCR assay for the detection of Zymomonas mobilis in distillers grains T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312865811; 5993546 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Rasmussen, M AU - Benahmed, F Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Grain KW - Polymerase chain reaction KW - Nucleotide sequence KW - Zymomonas mobilis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312865811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Development+of+a+PCR+assay+for+the+detection+of+Zymomonas+mobilis+in+distillers+grains&rft.au=Rasmussen%2C+M%3BBenahmed%2C+F&rft.aulast=Rasmussen&rft.aufirst=M&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Sensory attributes of yogurt fortified with predigested, nongerminated or germinated whole soy powder T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312862321; 5994037 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Nsofor, U AU - Ustunol, Z Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Yogurt KW - Sensory properties KW - Powder KW - Soybeans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312862321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Sensory+attributes+of+yogurt+fortified+with+predigested%2C+nongerminated+or+germinated+whole+soy+powder&rft.au=Nsofor%2C+U%3BUstunol%2C+Z&rft.aulast=Nsofor&rft.aufirst=U&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Manufacturing Process Controls for Controlled Release Dosage Forms T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312881763; 5984966 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Shrinkant, P AU - Yu, A AU - Sloan, M Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Manufacturing industry KW - Controlled release UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312881763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Manufacturing+Process+Controls+for+Controlled+Release+Dosage+Forms&rft.au=Shrinkant%2C+P%3BYu%2C+A%3BSloan%2C+M&rft.aulast=Shrinkant&rft.aufirst=P&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using the BCS as a Tool for Interpreting the In Vivo Relevance of In Vitro Dissolution Data in Dogs T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312879112; 5984476 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Martinez, M Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Data processing KW - Dissolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312879112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Using+the+BCS+as+a+Tool+for+Interpreting+the+In+Vivo+Relevance+of+In+Vitro+Dissolution+Data+in+Dogs&rft.au=Martinez%2C+M&rft.aulast=Martinez&rft.aufirst=M&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quantifying Variability in Drug Absorption T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312859647; 5984415 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Lionberger, Robert Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Absorption KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312859647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Quantifying+Variability+in+Drug+Absorption&rft.au=Lionberger%2C+Robert&rft.aulast=Lionberger&rft.aufirst=Robert&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory frameworks for nanotechnology applications in food: Are they adequate? T2 - 2010 Euroscience Open Forum (ESOF 2010) AN - 866040412; 5965934 JF - 2010 Euroscience Open Forum (ESOF 2010) AU - Thurmond, Thane Y1 - 2010/07/02/ PY - 2010 DA - 2010 Jul 02 KW - nanotechnology KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866040412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Euroscience+Open+Forum+%28ESOF+2010%29&rft.atitle=Regulatory+frameworks+for+nanotechnology+applications+in+food%3A+Are+they+adequate%3F&rft.au=Thurmond%2C+Thane&rft.aulast=Thurmond&rft.aufirst=Thane&rft.date=2010-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Euroscience+Open+Forum+%28ESOF+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esof2010.org/programme/programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - JOUR T1 - A Repeat Call for the Banning of Asbestos AN - 918039039; 13640160 JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Schroeder, Jane C AU - Tilson, Hugh A AD - NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - A280 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Asbestos KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918039039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Repeat+Call+for+the+Banning+of+Asbestos&rft.au=Birnbaum%2C+Linda+S%3BSchroeder%2C+Jane+C%3BTilson%2C+Hugh+A&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-07-01&rft.volume=118&rft.issue=7&rft.spage=A280&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Asbestos DO - http://dx.doi.org/10.1289/ehp.1002419 ER - TY - JOUR T1 - Chrysotile Asbestos and Mesothelioma AN - 918037690; 13640161 JF - Environmental Health Perspectives AU - Lemen, Richard A AD - U.S. Public Health Service (retired), National Institute for Occupational Safety Health (retired), Canton, Georgia, Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - A282 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Asbestos KW - mesothelioma KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918037690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Chrysotile+Asbestos+and+Mesothelioma&rft.au=Lemen%2C+Richard+A&rft.aulast=Lemen&rft.aufirst=Richard&rft.date=2010-07-01&rft.volume=118&rft.issue=7&rft.spage=A282&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002446 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Asbestos; mesothelioma DO - http://dx.doi.org/10.1289/ehp.1002446 ER - TY - JOUR T1 - Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan AN - 904467246; 14317441 AB - Abstract not available. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Stingley, Robin L AU - Beland, Frederick A AU - Harrouk, Wafa AU - Lumpkins, Debbie L AU - Howard, Paul AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 147 EP - 171 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 28 IS - 3 SN - 1059-0501, 1059-0501 KW - Pollution Abstracts; Toxicology Abstracts KW - Toxicity KW - Reviews KW - Carcinogenesis KW - Triclosan KW - Metabolism KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Occurrence%2C+Efficacy%2C+Metabolism%2C+and+Toxicity+of+Triclosan&rft.au=Stingley%2C+Robin+L%3BBeland%2C+Frederick+A%3BHarrouk%2C+Wafa%3BLumpkins%2C+Debbie+L%3BHoward%2C+Paul&rft.aulast=Stingley&rft.aufirst=Robin&rft.date=2010-07-01&rft.volume=28&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590501.2010.504978 L2 - http://www.informaworld.com/smpp/content~db=all~content=a927101215~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Carcinogenesis; Toxicity; Triclosan; Metabolism; Reviews DO - http://dx.doi.org/10.1080/10590501.2010.504978 ER - TY - JOUR T1 - Determination of malachite green and crystal violet in processed fish products AN - 902360567; 15760194 AB - This paper presents analysis of malachite green (MG) and crystal violet (CV) residues in processed fish products. Samples were homogenized and extracted with ammonium acetate buffer and acetonitrile. The extracted residues were partitioned into dichloromethane, in situ oxidized to chromic forms with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and cleaned up on neutral alumina and propylsulfonic acid cation-exchange solid-phase extraction (SPE) cartridges. MG and CV were determined at 618 and 588 nm using HPLC with a visible detector (LC-VIS) and confirmed by LC-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The recoveries were as follows: MG (74.8-83.8%), LMG (80.0-88.4%), CV (68.6-73.9%), and LCV (85.5-90.0%). The method modified in this study has been evaluated by application in-house to a survey of 253 processed fish products. As a result of monitoring, MG and CV were positive in one shrimp and one eel sample, respectively. Our results showed that regular monitoring of these antibiotic residues is recommended for protection of public health. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Lee, Jun Bae AU - Yun Kim, Hee AU - Mi Jang, Young AU - Young Song, Ji AU - Min Woo, Sung AU - Sun Park, Mi AU - Sook Lee, Hyun AU - Kyu Lee, Soon AU - Kim, Meehye AD - Imported Food Analysis Division, Korea Food and Drug Administration, Incheon 402-835, South Korea Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 953 EP - 961 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 27 IS - 7 SN - 1944-0049, 1944-0049 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Pollution Abstracts; Risk Abstracts KW - Risk assessment KW - Molecular structure KW - Biological surveys KW - Pollution monitoring KW - Ammonium KW - Residues KW - Catadromous species KW - Disease control KW - Mass spectrometry KW - Antibiotics KW - Public health KW - Food additives KW - Fish KW - Fishery products KW - Ammonium compounds KW - O 4080:Pollution - Control and Prevention KW - Q1 08625:Non-edible products KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902360567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Determination+of+malachite+green+and+crystal+violet+in+processed+fish+products&rft.au=Lee%2C+Jun+Bae%3BYun+Kim%2C+Hee%3BMi+Jang%2C+Young%3BYoung+Song%2C+Ji%3BMin+Woo%2C+Sung%3BSun+Park%2C+Mi%3BSook+Lee%2C+Hyun%3BKyu+Lee%2C+Soon%3BKim%2C+Meehye&rft.aulast=Lee&rft.aufirst=Jun&rft.date=2010-07-01&rft.volume=27&rft.issue=7&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440041003705839 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Biological surveys; Molecular structure; Food additives; Disease control; Catadromous species; Antibiotics; Ammonium compounds; Public health; Fishery products; Risk assessment; Ammonium; Pollution monitoring; Residues; Mass spectrometry; Fish DO - http://dx.doi.org/10.1080/19440041003705839 ER - TY - JOUR T1 - Livestock Handling-Minimizing Worker Injuries AN - 888106821; 15523699 AB - Numerous hazards may occur on farms raising livestock. Animal contact is often ranked as the first or second leading cause of injuries on the farm. In addition to direct trauma from the animal, other injuries may occur from injection of medications, chemical splashes from cleaning the facility, and repetitive motion injuries. Exposures to toxic gases from decomposition of animal waste such as in manure pits and exposure to animal allergens may cause adverse health effects in humans. One additional consideration is the risk of developing various zoonotic infections. Human injuries happen more often when people are handling animals than during any other activity performed in pork production. The National Pork Board of the United States, in response to a request from pork producers, has developed a program designed to improve worker safety, pig welfare, and pork quality when pigs are moved for whatever reason. The objective of the Transport Quality Assurance(TM) (TQA) program is to help all those who transport, produce, or handle swine to do so in a way that is optimal for the pigs' well-being, the health of the handler, and to improve the quality of the pork produced. Understanding basic pig behavior, proper handling practices, and using proper handling equipment will help animal handling be a safe activity. This paper was prepared for the Agricultural Safety and Health Council of America/National Institute of Occupational Safety and Health Conference, "Be Safe, Be Profitable: Protecting Workers in Agriculture," January 27-28, 2010, Dallas/Fort Worth, Texas. JF - Journal of Agromedicine AU - Langley, Ricky L AU - Morrow, WEMorgan AD - North Carolina Department of Health and Human Services, Division of Public Health, Raleigh, North Carolina, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 226 EP - 235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 3 SN - 1059-924X, 1059-924X KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Chemical spills KW - Injuries KW - Conferences KW - USA, Texas, Dallas KW - USA, Texas, Fort Worth KW - Livestock KW - Gases KW - farms KW - Allergens KW - councils KW - USA, Texas KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888106821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Livestock+Handling-Minimizing+Worker+Injuries&rft.au=Langley%2C+Ricky+L%3BMorrow%2C+WEMorgan&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.486327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Chemical spills; Gases; Conferences; Injuries; Allergens; farms; councils; Occupational exposure; Livestock; USA, Texas, Dallas; USA, Texas; USA, Texas, Fort Worth DO - http://dx.doi.org/10.1080/1059924X.2010.486327 ER - TY - JOUR T1 - Preventing Heat-Related Illness Among Agricultural Workers AN - 888097008; 15523710 AB - Hyperthermia from exertion and environmental conditions during agricultural work manifests itself by various symptoms and may lead to death. From 1992 through 2006, 68 workers employed in crop production and related services died from heat-related illness. The crop worker fatality rate averaged 4 heat-related deaths per one million workers per year-20 times higher than the 0.2 rate for US civilian workers overall. Many of the agricultural workers who died were foreign-born. Foreign-born workers tend to have limited English language skills and often are not acclimatized to exertion in hot weather when beginning seasonal jobs. Increased recognition of heat hazards to agricultural workers, in particular, has stimulated concern among employers, workers, and public policy makers. California and Washington have led the nation in adopting workplace safety standards designed to prevent heat-related illnesses. These state regulations include new specific requirements for employer provision of drinking water, shade for rest or other sufficient means to recover from heat, worker and supervisor training, and written heat safety plans. Agricultural employers face practical challenges in fulfilling the purpose and complying with these standards. By their very nature the standards impose generic requirements in a broad range of circumstances and may not be equally protective in all agricultural work settings. It is vital that employers and supervisors have a thorough knowledge of heat illness prevention to devise and implement safety measures that suit local conditions. Ongoing risk-based assessment of current heat conditions by employers is important to this safety effort. Workers need training to avoid heat illness and recognize the symptoms in themselves and coworkers. Innovative management practices are joining time-honored approaches to controlling heat stress and strain. Research targeted to answer questions about heat accumulation and dissipation during agricultural work and audience-sensitive education to promote understanding of basic physiology and recognition of hyperthermia symptoms can aid in heat illness prevention. This review was prepared for the Agricultural Safety and Health Council of America/ National Institute for Occupational Safety and Health conference, "Be Safe, Be Profitable: Protecting Workers in Agriculture," Dallas/Fort Worth, Texas, January 27-28, 2010. JF - Journal of Agromedicine AU - Jackson, Larry L AU - Rosenberg, Howard R AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virgina, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 200 EP - 215 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 3 SN - 1059-924X, 1059-924X KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - heat tolerance KW - Mortality KW - Training KW - USA, Texas, Dallas KW - Physiology KW - Occupational safety KW - USA, Texas, Fort Worth KW - USA, Washington KW - prevention KW - USA, California KW - USA, Texas KW - Environmental conditions KW - Drinking water KW - Ethnic groups KW - ENA 06:Food & Drugs KW - R2 23090:Policy and planning KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888097008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Preventing+Heat-Related+Illness+Among+Agricultural+Workers&rft.au=Jackson%2C+Larry+L%3BRosenberg%2C+Howard+R&rft.aulast=Jackson&rft.aufirst=Larry&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.487021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; heat tolerance; Training; Occupational safety; Physiology; prevention; Drinking water; Environmental conditions; Ethnic groups; USA, Washington; USA, Texas, Dallas; USA, Texas; USA, California; USA, Texas, Fort Worth DO - http://dx.doi.org/10.1080/1059924X.2010.487021 ER - TY - JOUR T1 - RT-GROG: parallelized self-calibrating GROG for real-time MRI AN - 883036347; 15255632 AB - A real-time implementation of self-calibrating Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) operator gridding for radial acquisitions is presented. Self-calibrating GRAPPA operator gridding is a parallel-imaging-based, parameter-free gridding algorithm, where coil sensitivity profiles are used to calculate gridding weights. Self-calibrating GRAPPA operator gridding's weight-set calculation and image reconstruction steps are decoupled into two distinct processes, implemented in C++ and parallelized. This decoupling allows the weights to be updated adaptively in the background while image reconstruction threads use the most recent gridding weights to grid and reconstruct images. All possible combinations of two-dimensional gridding weights GG are evaluated for m,n = {-0.5, -0.4, ..., ,0.1, ..., 0.5} and stored in a look-up table. Consequently, the per-sample two-dimensional weights calculation during gridding is eliminated from the reconstruction process and replaced by a simple look-up table access. In practice, up to 34X faster reconstruction than conventional (parallelized) self-calibrating GRAPPA operator gridding is achieved. On a 32-coil dataset of size 128 X 64, reconstruction performance is 14.5 frames per second (fps), while the data acquisition is 6.6 fps. Magn Reson Med 64:306-312, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Saybasili, Haris AU - Derbyshire, J Andrew AU - Kellman, Peter AU - Griswold, Mark A AU - Ozturk, Cengizhan AU - Lederman, Robert J AU - Seiberlich, Nicole AD - Translational Medicine Branch, National Institutes of Health/National Heart, Lung and Blood Institute (NHLBI), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, saybasilih@nhlbi.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 306 EP - 312 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 1 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Algorithms KW - Image processing KW - N.M.R. KW - Data acquisition KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=RT-GROG%3A+parallelized+self-calibrating+GROG+for+real-time+MRI&rft.au=Saybasili%2C+Haris%3BDerbyshire%2C+J+Andrew%3BKellman%2C+Peter%3BGriswold%2C+Mark+A%3BOzturk%2C+Cengizhan%3BLederman%2C+Robert+J%3BSeiberlich%2C+Nicole&rft.aulast=Saybasili&rft.aufirst=Haris&rft.date=2010-07-01&rft.volume=64&rft.issue=1&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22351 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22351/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Algorithms; Image processing; N.M.R.; Data acquisition DO - http://dx.doi.org/10.1002/mrm.22351 ER - TY - RPRT T1 - FOREWORD AN - 878683487 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 878683481; 21031006 AB - Ethinyl estradiol is a potent synthetic estrogen that is widely prescribed in oral contraceptives and is also used in the treatment of breast and prostate cancer. Ethinyl estradiol is one of a class of chemicals known as "environmental estrogens" that can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats were exposed to ethinyl estradiol for part or all of the study period and examined at the end of two years. The study consisted of three separate study components; in each, animals were exposed to ethinyl estradiol from the time of conception and through weaning through their mothers, who were given ethinyl estradiol in their feed. In one study we gave feed containing 2, 10, or 50 parts per billion (ppb) of ethinyl estradiol to groups of 50 male and female rats from conception through two years. In the second study, groups of 50 male and female rats were given the same feed concentrations up to 20 weeks following birth, followed by untreated feed for the remainder of the two years. In the third study groups of 50 male and female rats were exposed from conception through weaning, and then given untreated feed for the duration of the study. Control animals received the same feed with no ethinyl estradiol added. Enthinyl estradiol is known to cause cancer at higher dose levels; the concentrations given in this study were below the levels of detection by chemical analysis, to determine the possible effects of trace amounts in the environment. At the end of the study tissues from more than 40 sites were examined for every animal. In all three study sets effects were seen in the uterus of female rats. The rates of squamous metaplasia increased in females exposed for two years and in females exposed from conception through weaning; endometrial hyperplasia and atypical focal hyperplasia of the uterus also were increased in females exposed for two years. Uterine stromal polyps were increased in female rats exposed from conception through 20 weeks after birth or from conception through weaning. Male rats exposed from conception through weaning had small increases in the rates of preputial gland tumors and three male rats in that study had rare mammary gland adenomas or carcinomas. We conclude that exposure to trace amounts of ethinyl estradiol during the period from conception through weaning may have been related to development of uterine stromal polyps in female rats and to preputial gland tumors and mammaiy gland tumors in male rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 EP - 210 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Ethinyl Estradiol KW - Rodents KW - Toxicology KW - Cancer KW - Estrogen KW - Reproductive system KW - Synthetic products KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Ethinyl Estradiol -- metabolism KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Ethinyl Estradiol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDY+OF+ETHINYL+ESTRADIOL+%28CAS+NO.+57-63-6%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683479 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Legal and Informal Adoption by Relatives in the U.S.: Comparative Characteristics and Well-Being from a Nationally Representative Sample International Transracial Adoption AN - 862780625 AB - A large, nationally representative sample of households is used to compare children legally adopted by relatives with those living with relatives in households that that did not include the child's biological parents (i.e., children in informal adoptions). As context, children legally and informally adopted by kin are also compared with adopted children generally and with the broader population of all U.S. children. Demographically, there were virtually no differences between children legally and informally adopted by kin, though these groups are distinct from U.S. children overall and from other adopted children. Children legally adopted by kin fared better than those adopted informally on several measures of health and well-being. Adapted from the source document. JF - Adoption Quarterly AU - Radel, Laura F AU - Bramlett, Matthew D AU - Waters, Annette AD - Office Assistant Secretary Planning Evaluation, U.S. Dept Health Human Services, Washington, DC laura.radel@hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 268 EP - 591 PB - Taylor & Francis, Philadelphia, PA VL - 13 IS - 3-4 SN - 1092-6755, 1092-6755 KW - adoption KW - relative adoption KW - kin adoption KW - foster care adoption KW - private adoption KW - Well Being KW - Households KW - Adoption KW - Parents KW - Children KW - Adopted Children KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862780625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adoption+Quarterly&rft.atitle=Legal+and+Informal+Adoption+by+Relatives+in+the+U.S.%3A+Comparative+Characteristics+and+Well-Being+from+a+Nationally+Representative+Sample+International+Transracial+Adoption&rft.au=Radel%2C+Laura+F%3BBramlett%2C+Matthew+D%3BWaters%2C+Annette&rft.aulast=Radel&rft.aufirst=Laura&rft.date=2010-07-01&rft.volume=13&rft.issue=3-4&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Adoption+Quarterly&rft.issn=10926755&rft_id=info:doi/10.1080%2F10926755.2010.537957 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-28 N1 - CODEN - ADQUFW N1 - SubjectsTermNotLitGenreText - Children; Well Being; Adopted Children; Households; Adoption; Parents DO - http://dx.doi.org/10.1080/10926755.2010.537957 ER - TY - JOUR T1 - Detection technologies for Bacillus anthracis: Prospects and challenges AN - 856756167; 13663480 AB - Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological agent of acute infectious disease anthrax, a lethal but rare disease of animals and humans in nature. With recent use of anthrax as a bioweapon, a number of techniques have been recently developed and evaluated to facilitate its rapid detection of B. anthracis in the environment as well as in point-of-care settings for humans suspected of exposure to the pathogen. Complex laboratory methods for B. anthracis identification are required since B. anthracis has similarities with other Bacillus species and its existence in both spore and vegetative forms. This review discusses current challenges and various improvements associated with anthrax agent detection. JF - Journal of Microbiological Methods AU - Rao, Shilpakala Sainath AU - Mohan, Ketha VK AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, United States Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 EP - 10 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 82 IS - 1 SN - 0167-7012, 0167-7012 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Anthrax KW - Bacillus anthracis KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856756167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=Detection+technologies+for+Bacillus+anthracis%3A+Prospects+and+challenges&rft.au=Rao%2C+Shilpakala+Sainath%3BMohan%2C+Ketha+VK%3BAtreya%2C+Chintamani+D&rft.aulast=Rao&rft.aufirst=Shilpakala&rft.date=2010-07-01&rft.volume=82&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2010.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Anthrax; Bacillus anthracis DO - http://dx.doi.org/10.1016/j.mimet.2010.04.005 ER - TY - JOUR T1 - Concurrent validity of the parent-completed Ages and Stages Questionnaires, 2nd Ed. with the Bayley Scales of Infant Development II in a low-risk sample AN - 839571094; 201101510 AB - Background This study assessed the concurrent validity of the Ages and Stages Questionnaire (ASQ) compared with Bayley Scales of Infant Development II (BSID II) amongst children aged 24 months. Methods who participated in the New York State Angler Cohort Child Development Study. Parents completed the 24-month ASQ to assess communication, personal-social, problem-solving ability, and fine and gross motor control. The BSID II was administered by a clinical psychologist at the 24-month home visit for cognitive and psychomotor assessment. The ASQ was scored using age-specific norms of <2 SDs below any domain mean to define failure. A BSID II score of <85 indicated mild or severe delay, while a score of <70 suggested a severe delay. Results Scores on the ASQ communication and personal-social domains were moderately correlated with the BSID II Mental Scale (R = 0.52, P < 0.001; R = 0.45, P < 0.01) and ASQ gross motor with the BSID II Motor Scale (R = 0.46, P < 0.01), whereas ASQ problem-solving and fine motor domains were not significantly correlated with BSID II scores. The ASQ had a sensitivity of 100% and specificity of 87% at 24 months (n = 40) for severely delayed status. Conclusions cost-effective method for clinicians and field-based researchers to reduce the number of standardized assessments required to identify developmentally delayed infants at age 24 months. Future studies should further assess the validity of the ASQs in larger, more diverse populations of infants. Adapted from the source document. JF - Child: Care, Health and Development AU - Gollenberg, A L AU - Lynch, C D AU - Jackson, L W AU - McGuinness, B M AU - Msall, M E AD - Eunice Kennedy Shriver, National Institute of Child Health and Human Development; National Institutes of Health; Department of Health and Human Services; Rockville, MD Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 485 EP - 490 PB - Blackwell Publishing, Oxford UK VL - 36 IS - 4 SN - 0305-1862, 0305-1862 KW - child development developmental screening diagnostic tests sensitivity and specificity KW - Fines KW - Cost effectiveness KW - Problem solving KW - Child development KW - Clinical psychologists KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Concurrent+validity+of+the+parent-completed+Ages+and+Stages+Questionnaires%2C+2nd+Ed.+with+the+Bayley+Scales+of+Infant+Development+II+in+a+low-risk+sample&rft.au=Gollenberg%2C+A+L%3BLynch%2C+C+D%3BJackson%2C+L+W%3BMcGuinness%2C+B+M%3BMsall%2C+M+E&rft.aulast=Gollenberg&rft.aufirst=A&rft.date=2010-07-01&rft.volume=36&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2009.01041.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Infants; Fines; Problem solving; Clinical psychologists; Cost effectiveness; Child development DO - http://dx.doi.org/10.1111/j.1365-2214.2009.01041.x ER - TY - JOUR T1 - Introduction: The Recovery Community Services Program AN - 758125112; 201010833 AB - This article traces the history of the Recovery Community Services Program (RCSP) from its inception in the Substance Abuse Mental Health Services Administration/Center for Substance Abuse Treatment (SAMHSA/CSAT) 1998 vision of communities of recovery engaged in the public dialogue about addiction, treatment, and recovery through the 2002 programmatic refocus onto the provision of social supports for recovery, designed and delivered by people who share the experience of addiction and recovery, that is, peers. It focuses on the role of peer-to-peer recovery support services in an evolving recovery-oriented system of care, lessons learned as the grant program has matured, and continuing challenges in this latest chapter of the ongoing history of the relationship between communities of recovery and formal systems of care. Following articles represent how these principles are embodied in RCSP communities across the nation. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Kaplan, Linda AU - Nugent, Catherine AU - Baker, Marsha AU - Clark, H Westley AU - Veysey, Bonita M AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 244 EP - 255 PB - Haworth/Taylor & Francis Group, Philadephia, PA VL - 28 IS - 3 SN - 0734-7324, 0734-7324 KW - Peers KW - Substance Abuse KW - Rehabilitation KW - Social Support KW - Community Services KW - Mental Health Services KW - Addiction KW - Treatment KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Introduction%3A+The+Recovery+Community+Services+Program&rft.au=Kaplan%2C+Linda%3BNugent%2C+Catherine%3BBaker%2C+Marsha%3BClark%2C+H+Westley%3BVeysey%2C+Bonita+M&rft.aulast=Kaplan&rft.aufirst=Linda&rft.date=2010-07-01&rft.volume=28&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2010.488522 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - ATQUE7 N1 - SubjectsTermNotLitGenreText - Rehabilitation; Addiction; Substance Abuse; Community Services; Treatment; Mental Health Services; Peers; Social Support DO - http://dx.doi.org/10.1080/07347324.2010.488522 ER - TY - JOUR T1 - Work Schedules and Health Behavior Outcomes at a Large Manufacturer AN - 754901377; 13554453 AB - There is evidence that work schedules may influence rates of unhealthy behaviors, suggesting that addressing work schedule challenges may improve health. Health Risk Assessment (HRA) survey responses were collected during 2000-2008 in a multinational chemical and coatings manufacturer. Responses of 26,442 were sufficiently complete for analysis. Rates of smoking, lack of exercise, moderate to high alcohol use, obesity (BMI.30), and short sleep duration were compared by work schedule type (day, night, or rotating shift) and daily work hours (8, 10, or 12 h). Prevalence rate ratios (RRs) were calculated, adjusting for age group, sex, marital/living status, job tenure, and occupational group. The reference group was 8-h day shift employees. Overall prevalence rates were: sleep duration of 6 h or less per night 47%, smoking 17.3%, no exercise 22.0%, BMI.30 28.3%, and moderate to heavy alcohol consumption 22.2%. Statistically significant RRs include the following: Short sleep duration: 10 h rotating shift (RR=1.6), 12 h day and 12 h rotating shifts (RR=1.3); Smoking: 12 h day and rotating shifts (RR=1.6), 10 and 12 h night and 8 h rotating shift (RR=1.4); No exercise: 8, 10, and 12 h rotating shifts (RR=1.2 to 1.3), 12 h day schedules (RR=1.3). Obesity (BMI.30): 8 and 10 h night shifts (RR=1.3 and 1.4, respectively). JF - Industrial Health AU - Bushnell, P T AU - Colombi, A AU - Caruso, C C AU - Tak, S W AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R17, Cincinnati, Ohio 45226, USA, PLB4@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 395 EP - 405 VL - 48 IS - 4 SN - 0019-8366, 0019-8366 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Smoking KW - Alcohol KW - Age KW - Behavior KW - obesity KW - marriage KW - working conditions KW - Working conditions KW - Coatings KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754901377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Work+Schedules+and+Health+Behavior+Outcomes+at+a+Large+Manufacturer&rft.au=Bushnell%2C+P+T%3BColombi%2C+A%3BCaruso%2C+C+C%3BTak%2C+S+W&rft.aulast=Bushnell&rft.aufirst=P&rft.date=2010-07-01&rft.volume=48&rft.issue=4&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Alcohol; Smoking; Age; Behavior; obesity; marriage; Working conditions; working conditions; Coatings ER - TY - JOUR T1 - Symptoms of Infectious Diseases in Travelers with Diabetes Mellitus: A Prospective Study With Matched Controls AN - 754868398; 13192039 AB - Background. Travelers with diabetes mellitus to developing countries are thought to have symptomatic infectious diseases more often and longer than travelers without diabetes. Evidence for this is needed. This study evaluates whether travelers with diabetes are at increased risk of symptomatic infectious diseases. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Roukens, Anna H AU - Geskus, Ronald B AU - Kint, JoanA AU - Coutinho, Roel A AU - Sonder, Gerard J AU - van den Hoek, Anneke AD - *Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 256 EP - 263 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 17 IS - 4 SN - 1195-1982, 1195-1982 KW - Risk Abstracts KW - Travel KW - diabetes mellitus KW - Developing countries KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Symptoms+of+Infectious+Diseases+in+Travelers+with+Diabetes+Mellitus%3A+A+Prospective+Study+With+Matched+Controls&rft.au=Baaten%2C+Gijs+G%3BRoukens%2C+Anna+H%3BGeskus%2C+Ronald+B%3BKint%2C+JoanA%3BCoutinho%2C+Roel+A%3BSonder%2C+Gerard+J%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2010-07-01&rft.volume=17&rft.issue=4&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2010.00423.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Travel; diabetes mellitus; Developing countries DO - http://dx.doi.org/10.1111/j.1708-8305.2010.00423.x ER - TY - JOUR T1 - Egg white as a blood coagulation surrogate. AN - 754147185; pmid-20649242 AB - Egg white, a protein-containing solution, is characterized as a blood coagulation surrogate for the acoustical and thermal evaluation of therapeutic ultrasound, especially high intensity focused ultrasound (HIFU) devices. Physical properties, including coagulation temperature, frequency dependent attenuation, sound speed, viscosity, and thermal properties, were measured as a function of temperature (20-95 degrees C). Thermal coagulation and attenuation (5-12 and 1 MHz) of cow blood, pig blood, and human blood also were assessed and compared with egg white. For a 30 s thermal exposure, both egg white and blood samples (3 mm thickness) started to denature at 65 degrees C and coagulate into an elastic gel at 85 degrees C. The attenuation of egg white was found to be similar to that of the blood samples, having values of 0.23f(1.09), 1.58f(0.61), and 2.7f(0.5) dB/cm at 20, 75, and 95 degrees C, respectively. This significant attenuation increase with temperature was determined to be caused mainly by bubble cavity formation. The other temperature-dependent parameters are also similar to the reported values for blood. These properties make egg white a potentially useful bench testing tool for the safety and efficacy evaluation of therapeutic ultrasound devices. JF - The Journal of the Acoustical Society of America AU - Liu, Yunbo AU - Maruvada, Subha AU - Herman, Bruce A AU - Harris, Gerald R AD - Center for Devices and Radiological Health, Food and Drug Administration, Building 62, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. yxl@cdrh.fda.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 480 EP - 489 VL - 128 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754147185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Egg+white+as+a+blood+coagulation+surrogate.&rft.au=Liu%2C+Yunbo%3BMaruvada%2C+Subha%3BHerman%2C+Bruce+A%3BHarris%2C+Gerald+R&rft.aulast=Liu&rft.aufirst=Yunbo&rft.date=2010-07-01&rft.volume=128&rft.issue=1&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Paving the Road to Mental Health Recovery AN - 754139345; 201022956 AB - In this poignant, insightful, and timely commentary by Larry Davidson and his colleagues, the authors profile individuals who suggest that it would be useful to have a "map" to guide them back from mental illnesses to a normal life. "Map" is a wonderful metaphor for the journey of mental health recovery-a journey of healing and transformation that enables individuals with mental health problems to live in communities of their choice while striving to achieve their full potential. Adapted from the source document. JF - Psychiatry AU - Power, A Kathryn AD - 1 Choke Cherry Road, Rockville, MD 20857 kathryn.power@samhsa.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 114 EP - 117 PB - The Guilford Press VL - 73 IS - 2 SN - 0033-2747, 0033-2747 KW - Healing KW - Mental illness KW - Colleagues KW - Recovery KW - Psychiatric disorders KW - Mental health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754139345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Paving+the+Road+to+Mental+Health+Recovery&rft.au=Power%2C+A+Kathryn&rft.aulast=Power&rft.aufirst=A&rft.date=2010-07-01&rft.volume=73&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Mental health; Mental illness; Colleagues; Healing; Recovery; Psychiatric disorders ER - TY - JOUR T1 - Reservoir diagnosis of longwall gobs through drawdown tests and decline curve analyses of gob gas venthole productions AN - 753851952; 2010-070243 JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Dougherty, Heather N AU - Karacan, C Ozgen AU - Goodman, Gerrit V R Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 851 EP - 857 PB - Elsevier, Oxford-New York VL - 47 IS - 5 SN - 1365-1609, 1365-1609 KW - mining KW - monitoring KW - methane KW - geologic hazards KW - underground mining KW - aliphatic hydrocarbons KW - alkanes KW - porosity KW - rock mechanics KW - fractures KW - organic compounds KW - longwall mining KW - hydrocarbons KW - reservoir properties KW - permeability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753851952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Reservoir+diagnosis+of+longwall+gobs+through+drawdown+tests+and+decline+curve+analyses+of+gob+gas+venthole+productions&rft.au=Dougherty%2C+Heather+N%3BKaracan%2C+C+Ozgen%3BGoodman%2C+Gerrit+V+R&rft.aulast=Dougherty&rft.aufirst=Heather&rft.date=2010-07-01&rft.volume=47&rft.issue=5&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2010.04.010 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; fractures; geologic hazards; hydrocarbons; longwall mining; methane; mining; monitoring; organic compounds; permeability; porosity; reservoir properties; rock mechanics; underground mining DO - http://dx.doi.org/10.1016/j.ijrmms.2010.04.010 ER - TY - JOUR T1 - Estimation of the biodynamic responses distributed at fingers and palm based on the total response of the hand-arm system AN - 753668946; 13211587 AB - The major objective of this study is to develop a modeling method for estimating the biodynamic responses distributed at the fingers and the palm of the hand based on the total driving-point mechanical impedance of the entire hand-arm system. A five degrees-of-freedom (DOF) model with a set of constraints proposed in this study was used in the estimation. Three sets of mechanical impedance data measured at the fingers and palm of the hand were used to examine the validity of the proposed method. The estimated response distributed at the palm was consistent with the measured data even when the real part of the impedance alone was used in the modeling (coefficient of correlation, r super(2) >= 0.902). Better agreements between the estimated and measured responses were obtained (r super(2) >= 0.929) when the magnitude and phase of the total impedance or the magnitude alone were used in the modeling estimation. In each case, the estimated response distributed at the fingers was also reliably correlated with the experimental data (r super(2) >= 0.726) but it was not as consistent with the experimental data as that distributed at the palm. The applications of the proposed method were also demonstrated using five other sets of reported experimental data. This study also demonstrated that the modeling method may also be used to assess the quality of the experimental data in some cases. As a special application of the acceptable data identified in this study, this study also defined a 2-DOF model for the construction of a hand-arm simulator for tool tests. The results of this study and the proposed modeling method are expected to contribute to the revision of ISO 10068 (1998). Relevance to industry - Prolonged exposure to intensive tool vibration could cause hand-arm vibration syndrome (HAVS). An effective approach to reduce the HAVS is to reduce the intensity of the vibration exposure. The proposed modeling method and the results of this study can be used to help develop better tools and anti-vibration devices for reducing the exposure. The modeling study can also be used to help develop the location-specific frequency weightings for assessing the risk of the location-specific disorders induced from the hand-transmitted vibration exposure. JF - International Journal of Industrial Ergonomics AU - Dong, Ren G AU - Rakheja, Subhash AU - McDowell, Thomas W AU - Welcome, Daniel E AU - Wu, John Z AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, WV 26505, USA, rkd6@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 425 EP - 436 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 40 IS - 4 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Vibration KW - hand-arm vibration syndrome KW - Ergonomics KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753668946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Estimation+of+the+biodynamic+responses+distributed+at+fingers+and+palm+based+on+the+total+response+of+the+hand-arm+system&rft.au=Dong%2C+Ren+G%3BRakheja%2C+Subhash%3BMcDowell%2C+Thomas+W%3BWelcome%2C+Daniel+E%3BWu%2C+John+Z&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2010-07-01&rft.volume=40&rft.issue=4&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2010.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Vibration; hand-arm vibration syndrome; Occupational exposure; Ergonomics DO - http://dx.doi.org/10.1016/j.ergon.2010.02.001 ER - TY - JOUR T1 - Multiplexed identification of different fish species by detection of parvalbumin, a common fish allergen gene: a DNA application of multi-analyte profiling (xMAPTM) technology AN - 753653106; 13324782 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Hildebrandt, Sabine AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Bioanalytical Chemistry, 5100 Paint Branch Parkway, College Park, MD 20740, USA, s-hildebrandt@gmx.net PY - 2010 SP - 1787 EP - 1796 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 397 IS - 5 SN - 1618-2642, 1618-2642 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Population genetics KW - Genes KW - Allergens KW - Profiling KW - DNA KW - Parvalbumin KW - Q5 08502:Methods and instruments KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753653106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Multiplexed+identification+of+different+fish+species+by+detection+of+parvalbumin%2C+a+common+fish+allergen+gene%3A+a+DNA+application+of+multi-analyte+profiling+%28xMAPTM%29+technology&rft.au=Hildebrandt%2C+Sabine&rft.aulast=Hildebrandt&rft.aufirst=Sabine&rft.date=2010-07-01&rft.volume=397&rft.issue=5&rft.spage=1787&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-010-3760-2 L2 - http://www.springerlink.com/content/g20486k78686451t/?p=168a223c7a6c478ba9a9dc22cda43de5&pi=20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Population genetics; Genes; Profiling; DNA; Allergens; Parvalbumin DO - http://dx.doi.org/10.1007/s00216-010-3760-2 ER - TY - JOUR T1 - A BOUNDING ESTIMATE OF NEUTRON DOSE BASED ON MEASURED PHOTON DOSE AROUND SINGLE PASS REACTORS AT THE HANFORD SITE AN - 746314607; 13196308 AB - Neutron and photon radiation survey records have been used to evaluate and develop a neutron to photon (NP) ratio to reconstruct neutron doses to workers around Hanford's single pass reactors that operated from 1945 to 1972. A total of 5,773 paired neutron and photon measurements extracted from 57 boxes of survey records were used in the development of the NP ratio. The development of the NP ratio enables the use of the recorded dose from an individual's photon dosimeter badge to be used to estimate the unmonitored neutron dose. The Pearson rank correlation between the neutron and photon measurements was 0.71. The NP ratio best fit a lognormal distribution with a geometric mean (GM) of 0.8, a geometric standard deviation (GSD) of 2.95, and the upper 95 super(th)% of this distribution was 4.75. An estimate of the neutron dose based on this NP ratio is considered bounding due to evidence that up to 70% of the total photon exposure received by workers around the single pass reactors occurs during shutdown maintenance and refueling activities when there is no significant neutron exposure. Thus when this NP ratio is applied to the total measured photon dose from an individual film badge dosimeter, the resulting neutron dose is considered bounded. JF - Health Physics AU - Taulbee, T D AU - Glover, SE AU - Macievic, G V AU - Hunacek, M AU - Smith, C AU - DeBord, G W AU - Morris, D AU - Fix, J AD - National Institute for Occupational Safety and Health (NIOSH), Office of Compensation Analysis and Support (OCAS), Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, ttaulbee@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 26 EP - 38 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 1 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Nuclear power plants KW - Occupational exposure KW - Maintenance KW - USA, Washington, Hanford Site KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746314607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=A+BOUNDING+ESTIMATE+OF+NEUTRON+DOSE+BASED+ON+MEASURED+PHOTON+DOSE+AROUND+SINGLE+PASS+REACTORS+AT+THE+HANFORD+SITE&rft.au=Taulbee%2C+T+D%3BGlover%2C+SE%3BMacievic%2C+G+V%3BHunacek%2C+M%3BSmith%2C+C%3BDeBord%2C+G+W%3BMorris%2C+D%3BFix%2C+J&rft.aulast=Taulbee&rft.aufirst=T&rft.date=2010-07-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181d4ee20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Nuclear power plants; Maintenance; Occupational exposure; USA, Washington, Hanford Site DO - http://dx.doi.org/10.1097/HP.0b013e3181d4ee20 ER - TY - JOUR T1 - Prevalence, characterization and clonal analysis of Escherichia coli O157: non-H7 serotypes that carry eae alleles AN - 746232693; 13057962 AB - AbstractWe examined O157:non-H7 strains isolated from various sources and geographical locations and found 15-57 strains to carry eae alleles, including a, b, e and -d, suggesting that these strains may be prevalent. All strains were serologically and genetically confirmed to be O157, but none were the H7 serotype or carried any trait virulence factors of the Escherichia coli O157:H7 serotype. Genetic H typing of the eae-positive strains showed that the a-eae-bearing strain was H45, while the b- and e-eae strains were H16 and the -d-eae strains were H39. The b- and e-eae-bearing O157:H16 strains shared 690% pulsed-field gel electrophoresis (PFGE) similarity and were distinct from the other strains that had other eae alleles. Interestingly, an e-eae O157:H16 strain isolated from meat in France shared PFGE similarity to the O157:H16 strains from water in the United States. Multilocus sequence typing showed that there is clonal diversity within the O157 serogroup, as some O157:non-H7 strains clustered with EPEC clonal groups, while others clustered within the ST-171 group of diverse strains and serotypes that had not previously included any strains from the O157 serogroup. Clonal analysis also showed that none of the eae-positive O157:non-H7 strains we examined were closely related to the pathogenic O157:H7 serotype. JF - FEMS Microbiology Letters AU - Feng, Peter CH AU - Keys, Christine AU - Lacher, David AU - Monday, Steven R AU - Shelton, Dan AU - Rozand, Christine AU - Rivas, Marta AU - Whittam, Thomas AD - 1Division of Microbiology, FDA, College Park, MD, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 62 EP - 67 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 308 IS - 1 SN - 0378-1097, 0378-1097 KW - Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - O157:non-H7 KW - eae alleles KW - clonality KW - Meat KW - Geographical distribution KW - Serotypes KW - Typing KW - virulence factors KW - Pulsed-field gel electrophoresis KW - Experimental allergic encephalomyelitis KW - multilocus sequence typing KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746232693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Prevalence%2C+characterization+and+clonal+analysis+of+Escherichia+coli+O157%3A+non-H7+serotypes+that+carry+eae+alleles&rft.au=Feng%2C+Peter+CH%3BKeys%2C+Christine%3BLacher%2C+David%3BMonday%2C+Steven+R%3BShelton%2C+Dan%3BRozand%2C+Christine%3BRivas%2C+Marta%3BWhittam%2C+Thomas&rft.aulast=Feng&rft.aufirst=Peter&rft.date=2010-07-01&rft.volume=308&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1111%2Fj.1574-6968.2010.01990.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Meat; Geographical distribution; Typing; Serotypes; virulence factors; Pulsed-field gel electrophoresis; Experimental allergic encephalomyelitis; multilocus sequence typing; Escherichia coli DO - http://dx.doi.org/10.1111/j.1574-6968.2010.01990.x ER - TY - JOUR T1 - Workplace spirometry monitoring for respiratory disease prevention: a methods review AN - 745723225; 13196776 AB - This report reviews methods applicable in workplace spirometry monitoring for the identification of individuals with excessive lung function decline. Specific issues addressed include 1) maintaining longitudinal spirometry data precision at an acceptable level so that declines due to adverse physiological processes in the lung can be readily detected in an individual; 2) applying interpretative strategies that have a high likelihood of identifying workers at risk of developing lung function impairment; and 3) enhancing effectiveness of spirometry monitoring for intervention and disease prevention. Applications in ongoing computerized spirometry monitoring programs are described that demonstrate approaches to improving spirometry data precision and quality, and facilitating informed decision-making on disease prevention. JF - International Journal of Tuberculosis and Lung Disease AU - Hnizdo, E AU - Glindmeyer, H W AU - Petsonk, EL AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ehnizdo@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 796 EP - 805 VL - 14 IS - 7 SN - 1027-3719, 1027-3719 KW - Risk Abstracts; Health & Safety Science Abstracts KW - tuberculosis KW - Mycobacterium KW - Lung KW - Reviews KW - intervention KW - Physiology KW - prevention KW - Respiratory function KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745723225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Workplace+spirometry+monitoring+for+respiratory+disease+prevention%3A+a+methods+review&rft.au=Hnizdo%2C+E%3BGlindmeyer%2C+H+W%3BPetsonk%2C+EL&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2010-07-01&rft.volume=14&rft.issue=7&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - tuberculosis; Lung; intervention; Reviews; Physiology; prevention; Respiratory function; Occupational health; Mycobacterium ER - TY - JOUR T1 - Effects of fire fighter protective ensembles on mobility and performance AN - 745713349; 12984665 AB - Many studies have shown that fire fighter turnout gear and equipment may restrict mobility. The restriction of movement is usually due to a decrease in range of motion (ROM). It is important to know how much the decrease in ROM affects performance. The aim of this study was to determine the effects of fire fighter protective ensembles on mobility and performance by measuring static and dynamic range of motion (ROM) and job-related tasks. Eight healthy adults (5 males, 3 females), aged 20-40 years, participated in this study. The study consisted of measuring a battery of motions and fire fighter specific tasks while wearing a standard fire fighter ensemble (SE) or regular light clothing (baseline or BL). Several BL ROM tests were significantly (p < 0.05) different from the SE test, including a decrease in shoulder flexion, cervical rotation and flexion, trunk lateral flexion, and stand and reach. There was a significant decrease in time from SE to baseline performing the one-arm search task and object lift. These overall findings support the need for a comprehensive ergonomic evaluation of protective clothing systems to ascertain human factors issues. The development of a Standard Ergonomics Test Practice for further use in laboratories that conduct personal protective systems evaluations using human test subjects is recommended. JF - Applied Ergonomics AU - Coca, Aitor AU - Williams, WJon AU - Roberge, Raymond J AU - Powell, Jeffrey B AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, USA, esq6@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 636 EP - 641 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 41 IS - 4 SN - 0003-6870, 0003-6870 KW - Health & Safety Science Abstracts KW - Fires KW - Protective clothing KW - Mobility KW - Human factors KW - Ergonomics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Effects+of+fire+fighter+protective+ensembles+on+mobility+and+performance&rft.au=Coca%2C+Aitor%3BWilliams%2C+WJon%3BRoberge%2C+Raymond+J%3BPowell%2C+Jeffrey+B&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2010-07-01&rft.volume=41&rft.issue=4&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2010.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fires; Protective clothing; Mobility; Human factors; Ergonomics DO - http://dx.doi.org/10.1016/j.apergo.2010.01.001 ER - TY - JOUR T1 - Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. AN - 733567235; 20305089 AB - Smith-Lemli-Opitz syndrome (SLOS) and lathosterolosis are malformation syndromes with cognitive deficits caused by mutations of 7-dehydrocholesterol reductase (DHCR7) and lathosterol 5-desaturase (SC5D), respectively. DHCR7 encodes the last enzyme in the Kandutsch-Russel cholesterol biosynthetic pathway, and impaired DHCR7 activity leads to a deficiency of cholesterol and an accumulation of 7-dehydrocholesterol. SC5D catalyzes the synthesis of 7-dehydrocholesterol from lathosterol. Impaired SC5D activity leads to a similar deficiency of cholesterol but an accumulation of lathosterol. Although the genetic and biochemical causes underlying both syndromes are known, the pathophysiological processes leading to the developmental defects remain unclear. To study the pathophysiological mechanisms underlying SLOS and lathosterolosis neurological symptoms, we performed quantitative proteomics analysis of SLOS and lathosterolosis mouse brain tissue and identified multiple biological pathways affected in Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) E18.5 embryos. These include alterations in mevalonate metabolism, apoptosis, glycolysis, oxidative stress, protein biosynthesis, intracellular trafficking, and cytoskeleton. Comparison of proteome alterations in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) brain tissues helps elucidate whether perturbed protein expression was due to decreased cholesterol or a toxic effect of sterol precursors. Validation of the proteomics results confirmed increased expression of isoprenoid and cholesterol synthetic enzymes. This alteration of isoprenoid synthesis may underlie the altered posttranslational modification of Rab7, a small GTPase that is functionally dependent on prenylation with geranylgeranyl, that we identified and validated in this study. These data suggested that although cholesterol synthesis is impaired in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) embryonic brain tissues the synthesis of nonsterol isoprenoids may be increased and thus contribute to SLOS and lathosterolosis pathology. This proteomics study has provided insight into the pathophysiological mechanisms of SLOS and lathosterolosis, and understanding these pathophysiological changes will help guide clinical therapy for SLOS and lathosterolosis. JF - Molecular & cellular proteomics : MCP AU - Jiang, Xiao-Sheng AU - Backlund, Peter S AU - Wassif, Christopher A AU - Yergey, Alfred L AU - Porter, Forbes D AD - NICHD, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA. jiangx@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1461 EP - 1475 VL - 9 IS - 7 KW - rab7 protein KW - 152989-05-4 KW - lathosterol KW - 80-99-9 KW - Cholesterol KW - 97C5T2UQ7J KW - lathosterol delta-5-dehydrogenase KW - EC 1.14.21.6 KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - 7-dehydrocholesterol reductase KW - EC 1.3.1.21 KW - Caspase 3 KW - EC 3.4.22.- KW - rab GTP-Binding Proteins KW - EC 3.6.5.2 KW - rab5 GTP-Binding Proteins KW - Mevalonic Acid KW - S5UOB36OCZ KW - Index Medicus KW - Molecular Structure KW - Animals KW - rab5 GTP-Binding Proteins -- metabolism KW - Enzyme Activation KW - Mice KW - Mice, Knockout KW - Brain -- enzymology KW - Mevalonic Acid -- metabolism KW - Molecular Sequence Data KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - rab GTP-Binding Proteins -- metabolism KW - Female KW - Caspase 3 -- metabolism KW - Smith-Lemli-Opitz Syndrome -- metabolism KW - Proteomics -- methods KW - Metabolic Networks and Pathways -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Cholesterol -- biosynthesis KW - Cholesterol -- metabolism KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- deficiency KW - Smith-Lemli-Opitz Syndrome -- pathology KW - Cholesterol -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733567235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+%26+cellular+proteomics+%3A+MCP&rft.atitle=Quantitative+proteomics+analysis+of+inborn+errors+of+cholesterol+synthesis%3A+identification+of+altered+metabolic+pathways+in+DHCR7+and+SC5D+deficiency.&rft.au=Jiang%2C+Xiao-Sheng%3BBacklund%2C+Peter+S%3BWassif%2C+Christopher+A%3BYergey%2C+Alfred+L%3BPorter%2C+Forbes+D&rft.aulast=Jiang&rft.aufirst=Xiao-Sheng&rft.date=2010-07-01&rft.volume=9&rft.issue=7&rft.spage=1461&rft.isbn=&rft.btitle=&rft.title=Molecular+%26+cellular+proteomics+%3A+MCP&rft.issn=1535-9484&rft_id=info:doi/10.1074%2Fmcp.M900548-MCP200 LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/mcp.M900548-MCP200 ER - TY - JOUR T1 - Cocaine responsiveness or anhedonia in rats treated with methylphenidate during adolescence. AN - 733561045; 20347964 AB - Methylphenidate (MPH) treatment in boys diagnosed with ADHD is reported to decrease the risk of drug abuse in adulthood. Similarly, MPH treatment appears to decrease the cocaine preference of male rats during conditioned place preference (CPP) tests. However, the effects of MPH treatment on later drug use of girls/women or CPP in female rodents have not been fully examined, nor have a clinically-relevant MPH dose and/or administration route been thoroughly studied. Here, Sprague-Dawley rats (n=34/sex/treatment) were treated orally 3x/day on postnatal days (PNDs) 29-50 with water or 3mg MPH/kg, a dose producing serum levels within the human clinical range. CPP assessments to cocaine (10 mg/kg, ip) (PNDs 62-71) indicated MPH-treated rats were less active during pre- and postconditioning sessions (p<.04), but there were no significant MPH-related differences in conditioning strength. Baseline open field activity at PND 84 indicated that MPH-treated females were more active than same-sex controls (p<.05). A cocaine challenge (10 mg/kg, ip) elevated activity similarly in MPH-treated and controls of both sexes. As an anhedonia measure, saccharin solution intake on PNDs 87-90 indicated no significant MPH effects. Estrous cycle phase did not appear to affect cocaine response during CPP or open field assessments. Hormonal levels at PND 90 indicated 63% higher corticosterone levels in MPH-treated females relative to same-sex controls (p<.05), a finding that deserves further investigation. These results address some of the major issues surrounding animal models of MPH treatment and provide additional support for a lack of severe long-term behavioral effects of adolescent MPH. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Boctor, Sherin Y AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States. Sherry.Ferguson@fda.hhs.gov PY - 2010 SP - 432 EP - 442 VL - 32 IS - 4 KW - Triiodothyronine KW - 06LU7C9H1V KW - Methylphenidate KW - 207ZZ9QZ49 KW - Testosterone KW - 3XMK78S47O KW - Estradiol KW - 4TI98Z838E KW - Cocaine KW - I5Y540LHVR KW - Thyroxine KW - Q51BO43MG4 KW - Corticosterone KW - W980KJ009P KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Age Factors KW - Sex Factors KW - Triiodothyronine -- blood KW - Thyroxine -- blood KW - Hydrocortisone -- blood KW - Rats KW - Estrous Cycle KW - Rats, Sprague-Dawley KW - Estradiol -- blood KW - Corticosterone -- blood KW - Exploratory Behavior -- drug effects KW - Testosterone -- blood KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Female KW - Male KW - Methylphenidate -- pharmacology KW - Choice Behavior -- drug effects KW - Cocaine -- pharmacology KW - Food Preferences -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733561045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Cocaine+responsiveness+or+anhedonia+in+rats+treated+with+methylphenidate+during+adolescence.&rft.au=Ferguson%2C+Sherry+A%3BBoctor%2C+Sherin+Y&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2010-07-01&rft.volume=32&rft.issue=4&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2010.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-07 N1 - Date created - 2010-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2010.03.007 ER - TY - JOUR T1 - Regulatory use of computational toxicology tools and databases at the United States Food and Drug Administration's Office of Food Additive Safety. AN - 733375731; 20491519 AB - Over 10 years ago, the Office of Food Additive Safety (OFAS) in the FDA's Center for Food Safety and Applied Nutrition implemented the formal use of structure-activity relationship analysis and quantitative structure-activity relationship (QSAR) analysis in the premarket review of food-contact substances. More recently, OFAS has implemented the use of multiple QSAR software packages and has begun investigating the use of metabolism data and metabolism predictive models in our QSAR evaluations of food-contact substances. In this article, we provide an overview of the programs used in OFAS as well as a perspective on how to apply multiple QSAR tools in the review process of a new food-contact substance. JF - Expert opinion on drug metabolism & toxicology AU - Arvidson, Kirk B AU - Chanderbhan, Ronald AU - Muldoon-Jacobs, Kristi AU - Mayer, Julie AU - Ogungbesan, Adejoke AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Kirk.Arvidson@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 793 EP - 796 VL - 6 IS - 7 KW - Food Additives KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Safety KW - Toxicology -- legislation & jurisprudence KW - Food Additives -- adverse effects KW - Computational Biology -- methods KW - Databases, Factual -- legislation & jurisprudence KW - Computational Biology -- legislation & jurisprudence KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733375731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Regulatory+use+of+computational+toxicology+tools+and+databases+at+the+United+States+Food+and+Drug+Administration%27s+Office+of+Food+Additive+Safety.&rft.au=Arvidson%2C+Kirk+B%3BChanderbhan%2C+Ronald%3BMuldoon-Jacobs%2C+Kristi%3BMayer%2C+Julie%3BOgungbesan%2C+Adejoke&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2010-07-01&rft.volume=6&rft.issue=7&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2010.493555 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-24 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2010.493555 ER - TY - JOUR T1 - Computational science in drug metabolism and toxicology. AN - 733374107; 20465524 AB - Computational scientific tools involving construction and testing of models, screening and data mining for drug and chemical induced toxicities and metabolism have significantly grown in experimental use to help guide product development and assist by enhancing certain areas of regulatory decision making. This themed issue of the journal entitled Computational Science in Drug Metabolism & Toxicology contains state-of-the-art review articles and perspectives covering a diversity of in silico approaches. Computational science tools have a strong potential for expediting our further understanding of drug metabolism and toxicity and are continually being developed and validated. The reader will gain an understanding of the current state of in silico tools and modeling approaches aimed at reducing these liabilities. In addition, how these tools are tested and developed for use in drug safety to support drug development efforts and a review of how they are used to predict genotoxic liabilities are covered in this issue. Computational science tools when properly validated and used judiciously can lend themselves as enablers to support drug safety assessment in investigative and applied settings. JF - Expert opinion on drug metabolism & toxicology AU - Valerio, Luis G AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Office of Pharmaceutical Science, White Oak 51 Room 4128, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Luis.Valerio@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 781 EP - 784 VL - 6 IS - 7 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Pharmaceutical Preparations -- metabolism KW - Toxicology -- trends KW - Computational Biology -- methods KW - Toxicology -- methods KW - Computational Biology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733374107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Computational+science+in+drug+metabolism+and+toxicology.&rft.au=Valerio%2C+Luis+G&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-07-01&rft.volume=6&rft.issue=7&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2010.486789 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-24 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2010.486789 ER - TY - JOUR T1 - Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. AN - 733352044; 20224926 AB - The potential for development of Parkinson's disease (PD)-like neurological dysfunction following occupational exposure to aerosolized welding fumes (WF) is an area of emerging concern. Welding consumables contain a complex mixture of metals, including iron (Fe) and manganese (Mn), which are known to be neurotoxic. To determine whether WF exposure poses a neurological risk particularly to the dopaminergic system, we treated Sprague-Dawley rats with WF particulates generated from two different welding processes, gas metal arc-mild steel (GMA-MS; low Mn, less water-soluble) and manual metal arc-hard surfacing (MMA-HS; high Mn, more water-soluble) welding. Following repeated intratracheal instillations (0.5 mg/rat, 1/week x 7 weeks) of GMA-MS or MMA-HS, elemental analysis and various molecular indices of neurotoxicity were measured at 1, 4, 35 or 105 days after last exposure. MMA-HS exposure, in particular, led to increased deposition of Mn in striatum and midbrain. Both fumes also caused loss of tyrosine hydroxylase (TH) protein in the striatum (~20%) and midbrain (~30%) by 1 day post-exposure. While the loss of TH following GMA-MS was transient, a sustained loss (34%) was observed in the midbrain 105 days after cessation of MMA-HS exposure. In addition, both fumes caused persistent down-regulation of dopamine D2 receptor (Drd2; 30-40%) and vesicular monoamine transporter 2 (Vmat2; 30-55%) mRNAs in the midbrain. WF exposure also modulated factors associated with synaptic transmission, oxidative stress, neuroinflammation and gliosis. Collectively, our findings demonstrate that repeated exposure to Mn-containing WF can cause persistent molecular alterations in dopaminergic targets. Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated. JF - Archives of toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Chapman, Rebecca S AU - Chen, Bean T AU - Soukup, Joleen M AU - Ghio, Andrew J AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 521 EP - 540 VL - 84 IS - 7 KW - Gases KW - 0 KW - Metals KW - Steel KW - 12597-69-2 KW - Manganese KW - 42Z2K6ZL8P KW - Iron KW - E1UOL152H7 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Neurotoxicity Syndromes KW - Gases -- metabolism KW - Lung -- metabolism KW - Iron -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Steel -- toxicity KW - Down-Regulation KW - Parkinson Disease KW - Metals -- metabolism KW - Male KW - Metals -- toxicity KW - Manganese -- metabolism KW - Welding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733352044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Dopaminergic+neurotoxicity+following+pulmonary+exposure+to+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BChapman%2C+Rebecca+S%3BChen%2C+Bean+T%3BSoukup%2C+Joleen+M%3BGhio%2C+Andrew+J%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2010-07-01&rft.volume=84&rft.issue=7&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-010-0525-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-10 N1 - Date created - 2010-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00204-010-0525-9 ER - TY - JOUR T1 - Exposure-response of posaconazole used for prophylaxis against invasive fungal infections: evaluating the need to adjust doses based on drug concentrations in plasma. AN - 733333163; 20505665 AB - The purpose of this article is to report the exposure-response (E-R) relationship of posaconazole oral suspension (POS) for prophylaxis against invasive fungal infections (IFIs), on the basis of the US Food and Drug Administration (FDA) clinical pharmacology review of two randomized, active-controlled clinical studies. Posaconazole average steady state plasma concentrations (C(avg)) ranged from 22 to 3,650 ng/ml after administration of POS 200 mg three times daily (t.i.d.). In a double-blind, randomized clinical trial, the quartile ranges of C(avg) with midpoint values of 289, 736, 1,239, and 2,607 ng/ml had clinical failure rates of 44, 21, 18, and 18%, respectively, indicating an inverse association between C(avg) and clinical failure rate. There were no significant relationships between C(avg) and posaconazole-related major adverse events. Determining posaconazole concentrations in plasma will aid in assessing the need for either POS dose adjustment (e.g., increasing the POS dose) or switching to another systemic antifungal drug, thereby improving the effectiveness of prophylaxis against IFIs. JF - Clinical pharmacology and therapeutics AU - Jang, S H AU - Colangelo, P M AU - Gobburu, J V S AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. seong.jang@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 115 EP - 119 VL - 88 IS - 1 KW - Antifungal Agents KW - 0 KW - Antineoplastic Agents KW - Triazoles KW - posaconazole KW - 6TK1G07BHZ KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Neutropenia -- complications KW - Treatment Outcome KW - Neutropenia -- chemically induced KW - Stem Cell Transplantation KW - Graft vs Host Disease -- complications KW - Antineoplastic Agents -- adverse effects KW - Antifungal Agents -- pharmacokinetics KW - Mycoses -- prevention & control KW - Antifungal Agents -- administration & dosage KW - Triazoles -- therapeutic use KW - Triazoles -- pharmacokinetics KW - Triazoles -- administration & dosage KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733333163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Exposure-response+of+posaconazole+used+for+prophylaxis+against+invasive+fungal+infections%3A+evaluating+the+need+to+adjust+doses+based+on+drug+concentrations+in+plasma.&rft.au=Jang%2C+S+H%3BColangelo%2C+P+M%3BGobburu%2C+J+V+S&rft.aulast=Jang&rft.aufirst=S&rft.date=2010-07-01&rft.volume=88&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2010.64 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-01 N1 - Date created - 2010-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Pharmacol Ther. 2011 Mar;89(3):351-2 [21270787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2010.64 ER - TY - JOUR T1 - No role for human papillomavirus in esophageal squamous cell carcinoma in China. AN - 733295015; 19918949 AB - Certain regions of China have high rates of esophageal squamous cell carcinoma (ESCC). Previous studies of human papillomavirus (HPV), a proposed causal factor, have produced highly variable results. We attempted to evaluate HPV and ESCC more definitively using extreme care to prevent DNA contamination. We collected tissue and serum in China from 272 histopathologically-confirmed ESCC cases with rigorous attention to good molecular biology technique. We tested for HPV DNA in fresh-frozen tumor tissue using PCR with PGMY L1 consensus primers and HPV16 and 18 type-specific E6 and E7 primers, and in formalin-fixed paraffin-embedded tumor tissue using SPF(10) L1 primers. In HPV-positive cases, we evaluated p16(INK4a) overexpression and HPV E6/E7 seropositivity as evidence of carcinogenic HPV activity. beta-globin, and thus DNA, was adequate in 98.2% of the frozen tumor tissues (267/272). Of these, 99.6% (95% confidence interval (CI) = 97.9-100.0%) were negative for HPV DNA by PGMY, and 100% (95% CI = 98.6-100%) were negative by HPV16/18 E6/E7 PCR. In the corresponding formalin-fixed paraffin-embedded tumor specimens, 99.3% (95% CI = 97.3-99.9%) were HPV negative by SPF(10). By PGMY, 1 case tested weakly positive for HPV89, a noncancer causing HPV type. By SPF(10), 2 cases tested weakly positive: 1 for HPV16 and 1 for HPV31. No HPV DNA-positive case had evidence of HPV oncogene activity as measured by p16(INK4a) overexpression or E6/E7 seropositivity. This study provides the most definitive evidence to date that HPV is not involved in ESCC carcinogenesis in China. HPV DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ESCC tissue studies with less stringent tissue procurement and processing protocols. JF - International journal of cancer AU - Koshiol, Jill AU - Wei, Wen-Qiang AU - Kreimer, Aimee R AU - Chen, Wen AU - Gravitt, Patti AU - Ren, Jian-Song AU - Abnet, Christian C AU - Wang, Jian-Bing AU - Kamangar, Farin AU - Lin, Dong-Mei AU - von Knebel-Doeberitz, Magnus AU - Zhang, Yu AU - Viscidi, Raphael AU - Wang, Guo-Qing AU - Gillison, Maura L AU - Roth, Mark J AU - Dong, Zhi-Wei AU - Kim, Esther AU - Taylor, Philip R AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852-7248, USA. koshiolj@mail.nih.gov Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 93 EP - 100 VL - 127 IS - 1 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - DNA, Viral -- genetics KW - Male KW - Female KW - China KW - Papillomaviridae -- pathogenicity KW - Esophageal Neoplasms -- virology KW - Carcinoma, Squamous Cell -- pathology KW - Papillomaviridae -- genetics KW - Carcinoma, Squamous Cell -- virology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=No+role+for+human+papillomavirus+in+esophageal+squamous+cell+carcinoma+in+China.&rft.au=Koshiol%2C+Jill%3BWei%2C+Wen-Qiang%3BKreimer%2C+Aimee+R%3BChen%2C+Wen%3BGravitt%2C+Patti%3BRen%2C+Jian-Song%3BAbnet%2C+Christian+C%3BWang%2C+Jian-Bing%3BKamangar%2C+Farin%3BLin%2C+Dong-Mei%3Bvon+Knebel-Doeberitz%2C+Magnus%3BZhang%2C+Yu%3BViscidi%2C+Raphael%3BWang%2C+Guo-Qing%3BGillison%2C+Maura+L%3BRoth%2C+Mark+J%3BDong%2C+Zhi-Wei%3BKim%2C+Esther%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2010-07-01&rft.volume=127&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 2004 Feb 15;189(4):686-98 [14767823] Am J Epidemiol. 2007 Jun 15;165(12):1424-33 [17420181] J Med Virol. 2004 Sep;74(1):107-16 [15258976] Am J Obstet Gynecol. 2004 Sep;191(3):757-61 [15467536] Obstet Gynecol. 1989 Dec;74(6):950-4 [2555753] Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):341-7 [8061584] Zhonghua Zhong Liu Za Zhi. 1995 Sep;17(5):321-4 [8697965] J Clin Microbiol. 1998 Feb;36(2):475-80 [9466762] Hum Pathol. 1998 Mar;29(3):266-71 [9496830] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] Am J Pathol. 1998 Dec;153(6):1741-8 [9846965] Int J Cancer. 1999 Apr 12;81(2):225-8 [10188723] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Anticancer Res. 2008 Mar-Apr;28(2B):1133-8 [18505048] J Clin Microbiol. 2008 Oct;46(10):3437-45 [18716224] Cancer. 2008 Nov 15;113(10 Suppl):3036-46 [18980286] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):251-3 [19105334] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Cancer Causes Control. 2009 Nov;20(9):1705-13 [19705288] Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Scand J Gastroenterol. 2000 Feb;35(2):123-30 [10720108] J Natl Cancer Inst. 2000 Nov 1;92(21):1753-63 [11058618] Int J Cancer. 2001 Apr 15;92(2):276-84 [11291057] Carcinogenesis. 2001 Jun;22(6):929-34 [11375901] J Immunol Methods. 2001 Jul 1;253(1-2):153-62 [11384677] J Clin Pathol. 2002 Oct;55(10):721-8 [12354793] Int J Cancer. 2002 Nov 20;102(3):271-4 [12397650] Eur J Cancer. 2002 Nov;38(17):2229-42 [12441259] Int J Cancer. 2003 Feb 10;103(4):496-500 [12478665] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] J Natl Cancer Inst Monogr. 2003;(31):57-65 [12807947] J Natl Cancer Inst Monogr. 2003;(31):80-8 [12807950] Arch Pathol Lab Med. 2003 Aug;127(8):940-5 [12873165] J Natl Cancer Inst. 2003 Sep 17;95(18):1414-6 [13130117] Sex Transm Infect. 2003 Oct;79(5):426-7 [14573848] J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83 [14652239] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] J Natl Cancer Inst. 2005 Feb 16;97(4):301-6 [15713965] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] Int J Epidemiol. 2005 Apr;34(2):467-74 [15659476] Carcinogenesis. 2005 Jul;26(7):1280-4 [15774487] Int J Cancer. 2006 Aug 1;119(3):579-84 [16496409] Int J Cancer. 2006 Sep 15;119(6):1354-9 [16615110] N Engl J Med. 2007 May 10;356(19):1944-56 [17494927] J Clin Microbiol. 2004 Jul;42(7):3176-84 [15243079] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25023 ER - TY - JOUR T1 - Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats. AN - 733148964; 19915844 AB - The antineoplastic anthracycline doxorubicin can induce a dose-dependent cardiomyopathy that limits the total cumulative dose prescribed to cancer patients. In both preclinical and clinical studies, pretreatment with dexrazoxane, an intracellular iron chelator, partially protects against anthracycline-induced cardiomyopathy. To identify potential additional cardioprotective treatment strategies, we investigated early doxorubicin-induced changes in cardiac gene expression. Spontaneously hypertensive male rats (n = 47) received weekly intravenous injections of doxorubicin (3 mg/kg) or saline 30 min after pretreatment with dexrazoxane (50 mg/kg) or saline by intraperitoneal injection. Cardiac samples were analyzed 24 h after the first (n = 20), second (n = 13), or third (n = 14) intravenous injection on days 1, 8, or 15 of the study, respectively. Rats receiving three doses of doxorubicin had minimal myocardial alterations that were attenuated by dexrazoxane. Cardiac expression levels of genes associated with the Nrf2-mediated stress response were increased after a single dose of doxorubicin, but not affected by cardioprotectant pretreatment. In contrast, an early repressive effect of doxorubicin on transcript levels of genes associated with mitochondrial function was attenuated by dexrazoxane pretreatment. Dexrazoxane had little effect on gene expression by itself. Genomic analysis provided further evidence that mitochondria are the primary target of doxorubicin-induced oxidative damage that leads to cardiomyopathy and the primary site of cardioprotective action by dexrazoxane. Additional strategies that prevent the formation of oxygen radicals by doxorubicin in mitochondria may provide increased cardioprotection. JF - Cancer chemotherapy and pharmacology AU - Thompson, Karol L AU - Rosenzweig, Barry A AU - Zhang, Jun AU - Knapton, Alan D AU - Honchel, Ronald AU - Lipshultz, Steven E AU - Retief, Jacques AU - Sistare, Frank D AU - Herman, Eugene H AD - Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. karol.thompson@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 303 EP - 314 VL - 66 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents KW - GA-Binding Protein Transcription Factor KW - Gabpb2 protein, rat KW - Troponin T KW - Razoxane KW - 5AR83PR647 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Rats, Inbred SHR KW - Troponin T -- metabolism KW - Troponin T -- blood KW - Oligonucleotide Array Sequence Analysis KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Reverse Transcriptase Polymerase Chain Reaction KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity KW - Rats KW - Gene Expression Profiling KW - Razoxane -- pharmacology KW - GA-Binding Protein Transcription Factor -- genetics KW - GA-Binding Protein Transcription Factor -- biosynthesis KW - Mitochondria, Heart -- drug effects KW - Mitochondria, Heart -- metabolism KW - Antineoplastic Agents -- pharmacology KW - Male KW - Myocardium -- pathology KW - Heart Diseases -- chemically induced KW - Heart Diseases -- metabolism KW - Doxorubicin -- toxicity KW - Heart Diseases -- prevention & control KW - Myocardium -- metabolism KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733148964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Early+alterations+in+heart+gene+expression+profiles+associated+with+doxorubicin+cardiotoxicity+in+rats.&rft.au=Thompson%2C+Karol+L%3BRosenzweig%2C+Barry+A%3BZhang%2C+Jun%3BKnapton%2C+Alan+D%3BHonchel%2C+Ronald%3BLipshultz%2C+Steven+E%3BRetief%2C+Jacques%3BSistare%2C+Frank+D%3BHerman%2C+Eugene+H&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2010-07-01&rft.volume=66&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1164-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-04 N1 - Date created - 2010-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1164-9 ER - TY - JOUR T1 - Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde. AN - 733128641; 20347909 AB - This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR). Levels of p53 codon 271 CGT to CAT and K-Ras codon 12 GGT to GAT mutations were quantified in nasal mucosa of rats exposed to formaldehyde. In addition, nasal mucosa cell proliferation was monitored because regenerative cell proliferation is considered a key event in formaldehyde-induced carcinogenesis. Male F344 rats (6-7 weeks old, 5 rats/group) were exposed to 0, 0.7, 2, 6, 10, and 15 ppm formaldehyde for 13 weeks (6 h/day, 5 days/week). ACB-PCR was used to determine levels of p53 and K-Ras mutations. Although two of five untreated rats had measureable spontaneous p53 mutant fractions (MFs), most nasal mucosa samples had p53 MFs below 10(-5). All K-Ras MF measurements were below 10(-5). No dose-related increases in p53 or K-Ras MF were observed, even though significant increases in bromodeoxyuridine incorporation demonstrated induced cell proliferation in the 10 and 15 ppm formaldehyde-treatment groups. Therefore, induction of tumor-associated p53 mutation likely occurs after several other key events in formaldehyde-induced carcinogenesis. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Meng, Fanxue AU - Bermudez, Edilberto AU - McKinzie, Page B AU - Andersen, Melvin E AU - Clewell, Harvey J AU - Parsons, Barbara L AD - US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA. Fanxue.Meng@fda.hhs.gov PY - 2010 SP - 274 EP - 283 VL - 57 IS - 2-3 KW - Codon KW - 0 KW - Tumor Suppressor Protein p53 KW - Formaldehyde KW - 1HG84L3525 KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - ras Proteins -- genetics KW - Polymerase Chain Reaction KW - Animals KW - Rats, Inbred F344 KW - Codon -- genetics KW - Dose-Response Relationship, Drug KW - Tumor Suppressor Protein p53 -- genetics KW - Male KW - Nasal Mucosa -- pathology KW - Nose Neoplasms -- genetics KW - Nose Neoplasms -- pathology KW - Nose Neoplasms -- chemically induced KW - Nasal Mucosa -- metabolism KW - Nasal Mucosa -- drug effects KW - Mutation KW - Formaldehyde -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733128641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Measurement+of+tumor-associated+mutations+in+the+nasal+mucosa+of+rats+exposed+to+varying+doses+of+formaldehyde.&rft.au=Meng%2C+Fanxue%3BBermudez%2C+Edilberto%3BMcKinzie%2C+Page+B%3BAndersen%2C+Melvin+E%3BClewell%2C+Harvey+J%3BParsons%2C+Barbara+L&rft.aulast=Meng&rft.aufirst=Fanxue&rft.date=2010-07-01&rft.volume=57&rft.issue=2-3&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2010.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-16 N1 - Date created - 2010-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2010.03.007 ER - TY - JOUR T1 - Release liner removal method for transdermal drug delivery systems (TDDS) AN - 1399904759; 16705422 AB - A release liner removal test is a valuable test for assessing the quality of a transdermal drug delivery system (i.e., TDDS, patch). This test measures the force required to remove the release liner from a patch. The objective of the present study was to establish sample preparation and instrument parameters for measuring release liner removal adhesion for TDDS. Ten TDDS were evaluated (six drugs for a total of 29 lots). Patches which had a rate-controlling membrane were run as-is, since they could not be cut to a precise width without sacrificing their structural integrity. Patches that were square or rectangular in shape were run as-is, and the width of these patches was determined using a digital caliper. Patches which were not square or rectangular in shape and did not have a rate-controlling membrane were cut to a precise width using a specimen cutter. Double-sided tape was used to adhere the liner side of the transdermal system to a clean stainless steel test panel. A release liner peel adhesion method for TDDS is proposed using a dwell time of approximately 3min, a peel angle of 90?, and a peel speed of 300mm/min. ? 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3177-3187, 2010 JF - Journal of Pharmaceutical Sciences AU - Wokovich, Anna M AU - Shen, Meiyu AU - Doub, William H AU - Machado, Stella G AU - Buhse, Lucinda F AD - Food and Drug Administration, Center for Drug Evaluation and Research, St. Louis, Missouri, anna.wokovich@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 3177 EP - 3187 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 99 IS - 7 SN - 1520-6017, 1520-6017 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Drug development KW - stainless steel KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399904759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Release+liner+removal+method+for+transdermal+drug+delivery+systems+%28TDDS%29&rft.au=Wokovich%2C+Anna+M%3BShen%2C+Meiyu%3BDoub%2C+William+H%3BMachado%2C+Stella+G%3BBuhse%2C+Lucinda+F&rft.aulast=Wokovich&rft.aufirst=Anna&rft.date=2010-07-01&rft.volume=99&rft.issue=7&rft.spage=3177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=15206017&rft_id=info:doi/10.1002%2Fjps.22067 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jps.22067/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Drug delivery; Drug development; stainless steel DO - http://dx.doi.org/10.1002/jps.22067 ER - TY - JOUR T1 - Pathways Among Exposure to Violence, Maternal Depression, Family Structure, and Child Outcomes Through Parenting: A Multigroup Analysis AN - 1081870432; 201206388 AB - The present study examined the impact of proximal (maternal depression, family structure) and distal (exposure to violence) risk factors on parenting characteristics (warmth, control), which were in turn hypothesized to affect child social-emotional functioning. Using the Family and Child Experiences Study (FACES) 2000 cohort, findings revealed that study variables were significant predictors of child social-emotional functioning. Despite limited significant pathways in the structural equation models, the cumulative effect of the variables resulted in models accounting for 21%-37% of the outcome. Multigroup analysis revealed that although the amount of variance explained varied, the model held across subgroups. Findings support theories such as the family stress model that suggest that family risk factors negatively influencing children's development through influencing parenting behaviors. Findings also support considering both warmth and control as key parenting dimensions. It may be impractical for practitioners to address the myriad of potential risks encountered by low-income families, but parents can be equipped with mental health services, parent education, and other assistance to help them maintain positive parenting practices in the face of challenges. [Copyright American Psychological Association] JF - American Journal of Orthopsychiatry AU - Westbrook, T'Pring R AU - Harden, Brenda Jones Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 386 EP - 400 PB - American Psychological Association, Washington DC VL - 80 IS - 3 SN - 0002-9432, 0002-9432 KW - parents KW - young children KW - Head Start KW - child adjustment KW - social skills KW - behavior problems KW - community violence KW - victimization KW - parent-child relations KW - family stress KW - depression KW - ethnicity KW - Depression (Psychology) KW - Risk Factors KW - Mothers KW - Family Structure KW - Child Development KW - Family Violence KW - Childrearing Practices KW - Parents KW - Children KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081870432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Pathways+Among+Exposure+to+Violence%2C+Maternal+Depression%2C+Family+Structure%2C+and+Child+Outcomes+Through+Parenting%3A+A+Multigroup+Analysis&rft.au=Westbrook%2C+T%27Pring+R%3BHarden%2C+Brenda+Jones&rft.aulast=Westbrook&rft.aufirst=T%27Pring&rft.date=2010-07-01&rft.volume=80&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/10.1111%2Fj.1939-0025.2010.01042.x LA - English DB - Social Services Abstracts N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Childrearing Practices; Children; Parents; Family Violence; Child Development; Family Structure; Depression (Psychology); Mothers; Risk Factors DO - http://dx.doi.org/10.1111/j.1939-0025.2010.01042.x ER - TY - JOUR T1 - Association Between IL-1A Single Nucleotide Polymorphisms and Chronic Beryllium Disease and Beryllium Sensitization AN - 1028075962; 14690978 AB - Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1 A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1 super(Glu69) in additive, dominant, and recessive inheritance models. Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. Conclusions: These results indicate that genetic variations in the IL-1 A gene may play a role in the development of CBD but not BeS. JF - Journal of Occupational and Environmental Medicine AU - McCanlies, E C AU - Yucesoy, B AU - Mnatsakanova, A AU - Sloven, JE AU - Andrew, M AU - Frye, B L AU - Schuler, C R AU - Kreiss, K AU - Weston, A AD - NIOSH, CDC, MS-L4050, 1095 Willowdale Road, Morgantown, WV 26505, USA, eim4@cdc.gov PY - 2010 SP - 680 EP - 684 VL - 52 IS - 7 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Berylliosis KW - Histocompatibility antigen HLA KW - Heredity KW - Interleukin 2 KW - Interleukin 1 KW - Nuclease KW - Interleukin 9 KW - Single-nucleotide polymorphism KW - Beryllium KW - Regression analysis KW - Interleukin 1 receptors KW - Polymerase chain reaction KW - N 14810:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028075962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Association+Between+IL-1A+Single+Nucleotide+Polymorphisms+and+Chronic+Beryllium+Disease+and+Beryllium+Sensitization&rft.au=McCanlies%2C+E+C%3BYucesoy%2C+B%3BMnatsakanova%2C+A%3BSloven%2C+JE%3BAndrew%2C+M%3BFrye%2C+B+L%3BSchuler%2C+C+R%3BKreiss%2C+K%3BWeston%2C+A&rft.aulast=McCanlies&rft.aufirst=E&rft.date=2010-07-01&rft.volume=52&rft.issue=7&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181e48ec8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Berylliosis; Interleukin 2; Heredity; Single-nucleotide polymorphism; Beryllium; Interleukin 1; Regression analysis; Polymerase chain reaction; Nuclease; Interleukin 1 receptors; Interleukin 9 DO - http://dx.doi.org/10.1097/JOM.0b013e3181e48ec8 ER - TY - JOUR T1 - Protecting Workers in Large-Scale Emergency Responses:NIOSH Experience in the Deepwater Horizon Response AN - 1020837063; 15498084 AB - On April 20, 2010, the Deepwater Horizon (DWH) semisubmersible Mobile Offshore Drilling Unit, located 45 miles southeast off the Louisiana coast, suffered a massive explosion and subsequent fire that ultimately led to the sinking of the Unit. Eleven workers lost their lives as a result of the explosion and fire, and seventeen other workers were injured. Oil from a subsea blowout began flowing into the Gulf of Mexico soon after the explosion, and continued to flow until the well was finally capped on July 15, 2010. JF - Journal of Occupational and Environmental Medicine AU - Kitt, M M AU - Decker, JA AU - Delaney, L AU - Funk, R AU - Halpin, J AU - Tepper, A AU - Spahr, J AU - Howard, J AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop E-20, Atlanta, GA 30333, USA, mkitt@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 711 EP - 715 VL - 53 IS - 7 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Coastal zone KW - Emergency preparedness KW - Explosions KW - Fires KW - Oil KW - ASW, USA, Louisiana KW - ASW, Mexico Gulf KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020837063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Protecting+Workers+in+Large-Scale+Emergency+Responses%3ANIOSH+Experience+in+the+Deepwater+Horizon+Response&rft.au=Kitt%2C+M+M%3BDecker%2C+JA%3BDelaney%2C+L%3BFunk%2C+R%3BHalpin%2C+J%3BTepper%2C+A%3BSpahr%2C+J%3BHoward%2C+J&rft.aulast=Kitt&rft.aufirst=M&rft.date=2010-07-01&rft.volume=53&rft.issue=7&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31822543b6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Oil; Fires; Coastal zone; Emergency preparedness; Explosions; ASW, Mexico Gulf; ASW, USA, Louisiana DO - http://dx.doi.org/10.1097/JOM.0b013e31822543b6 ER - TY - CPAPER T1 - Equity in the Finance and Delivery of Healthcare in the United States T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839635318; 5889032 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Selden, Thomas Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - USA KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839635318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Equity+in+the+Finance+and+Delivery+of+Healthcare+in+the+United+States&rft.au=Selden%2C+Thomas&rft.aulast=Selden&rft.aufirst=Thomas&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Got Meaningful Use? Implementing Programs and Policies to Achieve Widespread Use of Health Information Technology T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839635156; 5888815 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Harris, Yael Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Information technology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839635156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Got+Meaningful+Use%3F+Implementing+Programs+and+Policies+to+Achieve+Widespread+Use+of+Health+Information+Technology&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Literature Review and Evidence Synthesis T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634558; 5888956 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Chang, Stephanie AU - Jonas, Dan AU - McPheeters, Melissa AU - White, C Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Literature+Review+and+Evidence+Synthesis&rft.au=Chang%2C+Stephanie%3BJonas%2C+Dan%3BMcPheeters%2C+Melissa%3BWhite%2C+C&rft.aulast=Chang&rft.aufirst=Stephanie&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Talking the Talk: Best Practices in Effectively Communicating Research Results T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634511; 5888918 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Brach, Cindy AU - Mason, Diana Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Best practices KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Talking+the+Talk%3A+Best+Practices+in+Effectively+Communicating+Research+Results&rft.au=Brach%2C+Cindy%3BMason%2C+Diana&rft.aulast=Brach&rft.aufirst=Cindy&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Demystifying the Federal Grant Review Process: Focusing on Comparative Effectiveness Research T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839633018; 5888917 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Chesley, Francis AU - Ming, Tai-Seale Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Grants KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839633018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Demystifying+the+Federal+Grant+Review+Process%3A+Focusing+on+Comparative+Effectiveness+Research&rft.au=Chesley%2C+Francis%3BMing%2C+Tai-Seale&rft.aulast=Chesley&rft.aufirst=Francis&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Gender Differences in the Burden of Out-of-Pocket Health Care Expenditures T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632933; 5888858 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Taylor, Amy Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Sex KW - Health care KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Gender+Differences+in+the+Burden+of+Out-of-Pocket+Health+Care+Expenditures&rft.au=Taylor%2C+Amy&rft.aulast=Taylor&rft.aufirst=Amy&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Trends in Preventable Hospitalization Patterns among the Adults: A Small Area Analysis of U.S. States T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632920; 5888838 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Basu, Jayasree Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - USA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Trends+in+Preventable+Hospitalization+Patterns+among+the+Adults%3A+A+Small+Area+Analysis+of+U.S.+States&rft.au=Basu%2C+Jayasree&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - New Frontiers in Health Workforce Research: Rethinking the Data Infrastructure T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632617; 5888870 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Straw, Roger AU - Kronick, Richard AU - Moore, Jean AU - Salsburg, Edward AU - Skillman, Susan Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Infrastructure KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=New+Frontiers+in+Health+Workforce+Research%3A+Rethinking+the+Data+Infrastructure&rft.au=Straw%2C+Roger%3BKronick%2C+Richard%3BMoore%2C+Jean%3BSalsburg%2C+Edward%3BSkillman%2C+Susan&rft.aulast=Straw&rft.aufirst=Roger&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Pulmonary Vascular Resistance Index (PVRI) Is a Significant and Consistent Predictor of Exercise Capacity (6MWD) in Pulmonary Arterial Hypertension (PAH) Trials T2 - 9th International Pulmonary Hypertension Conference and Scientific Sessions AN - 839663128; 5912474 JF - 9th International Pulmonary Hypertension Conference and Scientific Sessions AU - Brar, S AU - Madabushi, R AU - Stockbridge, N AU - Gobburu, J AU - Jadhav, P Y1 - 2010/06/25/ PY - 2010 DA - 2010 Jun 25 KW - {Q1} KW - Hypertension KW - Lung KW - Physical training KW - Aromatic hydrocarbons KW - Circulatory system KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839663128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Pulmonary+Hypertension+Conference+and+Scientific+Sessions&rft.atitle=Pulmonary+Vascular+Resistance+Index+%28PVRI%29+Is+a+Significant+and+Consistent+Predictor+of+Exercise+Capacity+%286MWD%29+in+Pulmonary+Arterial+Hypertension+%28PAH%29+Trials&rft.au=Brar%2C+S%3BMadabushi%2C+R%3BStockbridge%2C+N%3BGobburu%2C+J%3BJadhav%2C+P&rft.aulast=Brar&rft.aufirst=S&rft.date=2010-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Pulmonary+Hypertension+Conference+and+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.phaonlineuniv.org/sites/default/files/presentations/2010_Sc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. AN - 733371686; 20481456 AB - Graphitic nanomaterials such as graphene layers (G) and single-wall carbon nanotubes (SWCNT) are potential candidates in a large number of biomedical applications. However, little is known about the effects of these nanomaterials on biological systems. Here we show that the shape of these materials is directly related to their induced cellular toxicity. Both G and SWCNT induce cytotoxic effects, and these effects are concentration- and shape-dependent. Interestingly, at low concentrations, G induced stronger metabolic activity than SWCNT, a trend that reversed at higher concentrations. Lactate dehydrogenase levels were found to be significantly higher for SWCNT as compared to the G samples. Moreover, reactive oxygen species were generated in a concentration- and time-dependent manner after exposure to G, indicating an oxidative stress mechanism. Furthermore, time-dependent caspase 3 activation after exposure to G (10 microg/mL) shows evidence of apoptosis. Altogether these studies suggest different biological activities of the graphitic nanomaterials, with the shape playing a primary role. JF - ACS nano AU - Zhang, Yongbin AU - Ali, Syed F AU - Dervishi, Enkeleda AU - Xu, Yang AU - Li, Zhongrui AU - Casciano, Daniel AU - Biris, Alexandru S AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. Y1 - 2010/06/22/ PY - 2010 DA - 2010 Jun 22 SP - 3181 EP - 3186 VL - 4 IS - 6 KW - Nanotubes, Carbon KW - 0 KW - Graphite KW - 7782-42-5 KW - Index Medicus KW - Rats KW - Animals KW - Particle Size KW - Materials Testing KW - PC12 Cells KW - Nanotubes, Carbon -- chemistry KW - Cell Survival -- drug effects KW - Graphite -- toxicity KW - Nanotubes, Carbon -- ultrastructure KW - Apoptosis -- drug effects KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733371686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+nano&rft.atitle=Cytotoxicity+effects+of+graphene+and+single-wall+carbon+nanotubes+in+neural+phaeochromocytoma-derived+PC12+cells.&rft.au=Zhang%2C+Yongbin%3BAli%2C+Syed+F%3BDervishi%2C+Enkeleda%3BXu%2C+Yang%3BLi%2C+Zhongrui%3BCasciano%2C+Daniel%3BBiris%2C+Alexandru+S&rft.aulast=Zhang&rft.aufirst=Yongbin&rft.date=2010-06-22&rft.volume=4&rft.issue=6&rft.spage=3181&rft.isbn=&rft.btitle=&rft.title=ACS+nano&rft.issn=1936-086X&rft_id=info:doi/10.1021%2Fnn1007176 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-08 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nn1007176 ER - TY - CPAPER T1 - Nanotechnology EHS Overview T2 - 2010 Symposium on Environment, Health & Safety AN - 839698997; 5927148 JF - 2010 Symposium on Environment, Health & Safety AU - Geraci, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839698997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Nanotechnology+EHS+Overview&rft.au=Geraci%2C+C&rft.aulast=Geraci&rft.aufirst=C&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Lessons learned from the field, how to protect yourself from occupational exposure to engineered nanomaterials T2 - 2010 Symposium on Environment, Health & Safety AN - 839696954; 5927164 JF - 2010 Symposium on Environment, Health & Safety AU - Hodson, L AU - Geraci, C AU - Methner, M AU - Crawford, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Occupational exposure KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839696954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Lessons+learned+from+the+field%2C+how+to+protect+yourself+from+occupational+exposure+to+engineered+nanomaterials&rft.au=Hodson%2C+L%3BGeraci%2C+C%3BMethner%2C+M%3BCrawford%2C+C&rft.aulast=Hodson&rft.aufirst=L&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Ultra-Structural Analysis of the Interaction of Carboxylated Multi-Walled Carbon Nanotubes with Human Blood Platelets T2 - 2010 Symposium on Environment, Health & Safety AN - 839695521; 5927155 JF - 2010 Symposium on Environment, Health & Safety AU - Lacerda, S AU - Semberova, J AU - Holada, K AU - Simakova, O AU - Gelderman-Fuhrmann, M AU - Simak, J Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - Blood KW - Carbon KW - Platelets KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839695521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Ultra-Structural+Analysis+of+the+Interaction+of+Carboxylated+Multi-Walled+Carbon+Nanotubes+with+Human+Blood+Platelets&rft.au=Lacerda%2C+S%3BSemberova%2C+J%3BHolada%2C+K%3BSimakova%2C+O%3BGelderman-Fuhrmann%2C+M%3BSimak%2C+J&rft.aulast=Lacerda&rft.aufirst=S&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Applying Basic Risk Management Principles to Nanomaterial Processes T2 - 2010 Symposium on Environment, Health & Safety AN - 839695430; 5927162 JF - 2010 Symposium on Environment, Health & Safety AU - Geraci, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839695430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Applying+Basic+Risk+Management+Principles+to+Nanomaterial+Processes&rft.au=Geraci%2C+C&rft.aulast=Geraci&rft.aufirst=C&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Increasing Tractor Operator Protection through NIOSH Crops Research T2 - 2010 Annual International Meeting of American Society of Agricultural and Biological Engineers AN - 839699139; 5945675 JF - 2010 Annual International Meeting of American Society of Agricultural and Biological Engineers AU - McKenzie Jr, Eugene AU - Harris, J R Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Agricultural equipment KW - Crops KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839699139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+International+Meeting+of+American+Society+of+Agricultural+and+Biological+Engineers&rft.atitle=Increasing+Tractor+Operator+Protection+through+NIOSH+Crops+Research&rft.au=McKenzie+Jr%2C+Eugene%3BHarris%2C+J+R&rft.aulast=McKenzie+Jr&rft.aufirst=Eugene&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+International+Meeting+of+American+Society+of+Agricultural+and+Biological+Engineers&rft.issn=&rft_id=info:doi/ L2 - http://www.asabemeetings.org/10AIM-Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantitation of Steviol Glycosides from Stevia Species by High-Performance Liquid Chromatography T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839601161; 5882312 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Jaworska, Karolina AU - Delmonte, Pierluigi AU - Cacciola, Francesco AU - Hartwig, Andrea AU - Rader, Jeanne Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Liquid chromatography KW - Steviol glycosides KW - High-performance liquid chromatography KW - Quantitation KW - Glycosides KW - {Q2} KW - Stevia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839601161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Quantitation+of+Steviol+Glycosides+from+Stevia+Species+by+High-Performance+Liquid+Chromatography&rft.au=Jaworska%2C+Karolina%3BDelmonte%2C+Pierluigi%3BCacciola%2C+Francesco%3BHartwig%2C+Andrea%3BRader%2C+Jeanne&rft.aulast=Jaworska&rft.aufirst=Karolina&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development and Validation of LC/MS/MS for 10 Phthalate Metabolites in Human Urine T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839598367; 5882388 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Hong, Soon AU - Nam, Hye AU - Kang, Il AU - Kim, Tae AU - Cho, Sang AU - Jung, Su AU - Lee, Jang AU - Kim, Jun AU - Kang, Tae AU - Lee, Kwang AU - Yoon, Hae Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Phthalates KW - Metabolites KW - Urine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839598367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Development+and+Validation+of+LC%2FMS%2FMS+for+10+Phthalate+Metabolites+in+Human+Urine&rft.au=Hong%2C+Soon%3BNam%2C+Hye%3BKang%2C+Il%3BKim%2C+Tae%3BCho%2C+Sang%3BJung%2C+Su%3BLee%2C+Jang%3BKim%2C+Jun%3BKang%2C+Tae%3BLee%2C+Kwang%3BYoon%2C+Hae&rft.aulast=Hong&rft.aufirst=Soon&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Employment of an Ortogonal Normal Phase x Reversed Phase System for the Characterization of Stevia Rebaudiana T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839593714; 5882443 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Cacciola, Francesco AU - Delmonte, Pierluigi AU - Jaworska, Karolina AU - Mondello, Luigi AU - Rader, Jeanne Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Employment KW - {Q2} KW - Stevia rebaudiana KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839593714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Employment+of+an+Ortogonal+Normal+Phase+x+Reversed+Phase+System+for+the+Characterization+of+Stevia+Rebaudiana&rft.au=Cacciola%2C+Francesco%3BDelmonte%2C+Pierluigi%3BJaworska%2C+Karolina%3BMondello%2C+Luigi%3BRader%2C+Jeanne&rft.aulast=Cacciola&rft.aufirst=Francesco&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Molecular targets of epigenetic regulation and effectors of environmental influences AN - 762265106; 13200085 AB - The true understanding of what we currently define as epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression increased. The current explosion of research on epigenetics and the increasing documentation of the effects of various environmental factors on DNA methylation, chromatin modification, as well as on the expression of small non-coding RNAs (ncRNAs) have expanded the scope of research on the etiology of various diseases including cancer. The current review briefly discusses the molecular mechanisms of epigenetic regulation and expands the discussion with examples on the role of environment, such as the immediate environment during development, in inducing epigenetic changes and modulating gene expression. JF - Toxicology and Applied Pharmacology AU - Choudhuri, Supratim AU - Cui, Yue AU - Klaassen, Curtis D AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, MD, USA Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 378 EP - 393 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 245 IS - 3 SN - 0041-008X, 0041-008X KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts; Toxicology Abstracts KW - Cancer KW - epigenetics KW - DNA KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762265106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Molecular+targets+of+epigenetic+regulation+and+effectors+of+environmental+influences&rft.au=Choudhuri%2C+Supratim%3BCui%2C+Yue%3BKlaassen%2C+Curtis+D&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2010-06-15&rft.volume=245&rft.issue=3&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.03.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - epigenetics; DNA DO - http://dx.doi.org/10.1016/j.taap.2010.03.022 ER - TY - JOUR T1 - PERFLUOROOCTANE SULFONATE (PFOS) INDUCES REACTIVE OXYGEN SPECIES (ROS) PRODUCTION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS: ROLE IN ENDOTHELIAL PERMEABILITY AN - 746079379; 12920220 AB - Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Qian, Yong AU - Ducatman, Alan AU - Ward, Rebecca AU - Leonard, Steve AU - Bukowsld, Valerie AU - Guo, Nancy Lan AU - Shi, Xianglin AU - Vallyathan, Val AU - Castranova, Vincent AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 819 EP - 836 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 73 IS - 7-12 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Microvasculature KW - sulfonates KW - Data processing KW - Endothelial cells KW - Oxygen KW - Permeability KW - Reactive oxygen species KW - Acids KW - Actin KW - Filaments KW - Side effects KW - Occupational exposure KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=PERFLUOROOCTANE+SULFONATE+%28PFOS%29+INDUCES+REACTIVE+OXYGEN+SPECIES+%28ROS%29+PRODUCTION+IN+HUMAN+MICROVASCULAR+ENDOTHELIAL+CELLS%3A+ROLE+IN+ENDOTHELIAL+PERMEABILITY&rft.au=Qian%2C+Yong%3BDucatman%2C+Alan%3BWard%2C+Rebecca%3BLeonard%2C+Steve%3BBukowsld%2C+Valerie%3BGuo%2C+Nancy+Lan%3BShi%2C+Xianglin%3BVallyathan%2C+Val%3BCastranova%2C+Vincent&rft.aulast=Qian&rft.aufirst=Yong&rft.date=2010-06-15&rft.volume=73&rft.issue=7-12&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287391003689317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Microvasculature; Permeability; Data processing; Reactive oxygen species; Acids; Actin; Filaments; Occupational exposure; Side effects; Oxygen; sulfonates DO - http://dx.doi.org/10.1080/15287391003689317 ER - TY - JOUR T1 - Prospective study of body mass index, physical activity and thyroid cancer AN - 745719154; 13163634 AB - Increased body size and physical inactivity are positively related to risk of several cancers, but only few epidemiologic studies have investigated body-mass index (BMI) and physical activity in relation to thyroid cancer. We examined the relations of BMI and physical activity to thyroid cancer in a prospective cohort of 484,326 United States men and women, followed from 1995/1996 to 2003. During 3,490,300 person-years of follow-up, we documented 352 newly incident cases of thyroid cancer. The multivariate relative risks (RR) of thyroid cancer for BMI values of 18.5-24.9 (reference), 25.0-29.9 and 30 kg m-2 were 1.0, 1.27 and 1.39 [95% confidence interval (CI) = 1.05-1.85]. Adiposity predicted papillary thyroid cancers (RR comparing extreme BMI categories = 1.47; 95% CI = 1.03-2.10) and, based on small numbers, suggestively predicted follicular thyroid cancers (RR = 1.49; 95% CI = 0.79-2.82) and anaplastic thyroid cancers (RR = 5.80; 95% CI = 0.99-34.19). No relation with BMI was noted for medullary thyroid cancers (RR = 0.97; 95% CI = 0.27-3.43). The positive relation of BMI to total thyroid cancer was evident for men but not for women. However, the test of interaction (p = 0.463) indicated no statistically significant gender difference. Physical activity was unassociated with thyroid cancer. The RRs of total thyroid cancer for low (reference), intermediate, and high level of physical activity were 1.0, 1.01 and 1.01 (95% CI = 0.76-1.34, p for trend = 0.931), respectively. Our results support an adverse effect of adiposity on risk for developing total and papillary, and possibly follicular thyroid cancers. Based on only 15 cases, adiposity was unrelated to medullary thyroid cancers. Physical activity was unrelated to total thyroid cancer. JF - International Journal of Cancer AU - Leitzmann, Michael F AU - Brenner, Alina AU - Moore, Steven C AU - Koebnick, Corinna AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Ron, Elaine AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 2947 EP - 2956 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 12 SN - 0020-7136, 0020-7136 KW - Physical Education Index; Risk Abstracts KW - Statistics KW - Men KW - Body mass KW - Women KW - Thyroid KW - body size KW - Exercise KW - Sex differences KW - Cancer KW - Anthropometry KW - USA KW - body mass KW - Gender KW - physical activity KW - Trends KW - Side effects KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Prospective+study+of+body+mass+index%2C+physical+activity+and+thyroid+cancer&rft.au=Leitzmann%2C+Michael+F%3BBrenner%2C+Alina%3BMoore%2C+Steven+C%3BKoebnick%2C+Corinna%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BRon%2C+Elaine&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2010-06-15&rft.volume=126&rft.issue=12&rft.spage=2947&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24913 L2 - http://www3.interscience.wiley.com/journal/122613798/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Anthropometry; Statistics; Men; Body mass; Women; Exercise; Trends; Sex differences; Cancer; body mass; Gender; Thyroid; body size; physical activity; Side effects; USA DO - http://dx.doi.org/10.1002/ijc.24913 ER - TY - CPAPER T1 - ICH Quality Implementation Working Group Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754290953; 5829059 JF - 46th Annual Meeting of the Drug Information Association AU - Morefield, Elaine Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754290953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=ICH+Quality+Implementation+Working+Group+Update&rft.au=Morefield%2C+Elaine&rft.aulast=Morefield&rft.aufirst=Elaine&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enforcement Update from Ddmac T2 - 46th Annual Meeting of the Drug Information Association AN - 754289003; 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5829441 JF - 46th Annual Meeting of the Drug Information Association AU - Toigo, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754284094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Involving+Patients%3A+An+FDA+Perspective&rft.au=Toigo%2C+Theresa&rft.aulast=Toigo&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US GLP Regulations Facing Globalization Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754283849; 5829371 JF - 46th Annual Meeting of the Drug Information Association AU - Yao, Dalin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Globalization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+GLP+Regulations+Facing+Globalization+Challenges&rft.au=Yao%2C+Dalin&rft.aulast=Yao&rft.aufirst=Dalin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Authoring to Help Fda'S Review T2 - 46th Annual Meeting of the Drug Information Association AN - 754283799; 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5829040 JF - 46th Annual Meeting of the Drug Information Association AU - Sanhai, Wendy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Perspective+from+the+FDA&rft.au=Sanhai%2C+Wendy&rft.aulast=Sanhai&rft.aufirst=Wendy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Novel Adjuvants: Need for New Preclinical Assays to Evaluate Safety T2 - 46th Annual Meeting of the Drug Information Association AN - 754282868; 5829535 JF - 46th Annual Meeting of the Drug Information Association AU - Golding, Hana Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Adjuvants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Novel+Adjuvants%3A+Need+for+New+Preclinical+Assays+to+Evaluate+Safety&rft.au=Golding%2C+Hana&rft.aulast=Golding&rft.aufirst=Hana&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Randomization in Clinical Trials: A Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754282703; 5829472 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H M Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Randomization+in+Clinical+Trials%3A+A+Regulatory+Perspective&rft.au=Hung%2C+H+M&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Quality-by-design: Challenges and Opportunities T2 - 46th Annual Meeting of the Drug Information Association AN - 754282638; 5829254 JF - 46th Annual Meeting of the Drug Information Association AU - Woodcock, Janet Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Quality-by-design%3A+Challenges+and+Opportunities&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Compliance Considerations When Outsourcing in a Clinical Trial T2 - 46th Annual Meeting of the Drug Information Association AN - 754282086; 5828808 JF - 46th Annual Meeting of the Drug Information Association AU - Lewin, Constance Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - Clinical trials KW - Outsourcing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Regulatory+Compliance+Considerations+When+Outsourcing+in+a+Clinical+Trial&rft.au=Lewin%2C+Constance&rft.aulast=Lewin&rft.aufirst=Constance&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug Information and the Patient Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754281432; 5829440 JF - 46th Annual Meeting of the Drug Information Association AU - Smith, Nancy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug+Information+and+the+Patient+Perspective&rft.au=Smith%2C+Nancy&rft.aulast=Smith&rft.aufirst=Nancy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Key Components of the DSUR: Part 2 - Regulatory Authority Expectations and Implementation in the US T2 - 46th Annual Meeting of the Drug Information Association AN - 754281354; 5829423 JF - 46th Annual Meeting of the Drug Information Association AU - Unger, Ellis Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Key+Components+of+the+DSUR%3A+Part+2+-+Regulatory+Authority+Expectations+and+Implementation+in+the+US&rft.au=Unger%2C+Ellis&rft.aulast=Unger&rft.aufirst=Ellis&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug-device Combination Products: Quality Considerations from an FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754281281; 5829407 JF - 46th Annual Meeting of the Drug Information Association AU - Srinivasachar, Kasturi Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug-device+Combination+Products%3A+Quality+Considerations+from+an+FDA+Perspective&rft.au=Srinivasachar%2C+Kasturi&rft.aulast=Srinivasachar&rft.aufirst=Kasturi&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Electronic Registration and Listing: New Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754281141; 5829354 JF - 46th Annual Meeting of the Drug Information Association AU - Mazyck, David Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Electronic+Registration+and+Listing%3A+New+Challenges&rft.au=Mazyck%2C+David&rft.aulast=Mazyck&rft.aufirst=David&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Implementing Qbd in Fda'S Gmp Program T2 - 46th Annual Meeting of the Drug Information Association AN - 754281018; 5829187 JF - 46th Annual Meeting of the Drug Information Association AU - Shah, Vibhakar Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Implementing+Qbd+in+Fda%27S+Gmp+Program&rft.au=Shah%2C+Vibhakar&rft.aulast=Shah&rft.aufirst=Vibhakar&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Transition to Edrls: Highlights and Lessons Learned T2 - 46th Annual Meeting of the Drug Information Association AN - 754279856; 5829355 JF - 46th Annual Meeting of the Drug Information Association AU - Rahjou-Esfandiary, Leyla Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754279856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Transition+to+Edrls%3A+Highlights+and+Lessons+Learned&rft.au=Rahjou-Esfandiary%2C+Leyla&rft.aulast=Rahjou-Esfandiary&rft.aufirst=Leyla&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Agency Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754278852; 5828910 JF - 46th Annual Meeting of the Drug Information Association AU - Wilson, Stephen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=An+Agency+Perspective&rft.au=Wilson%2C+Stephen&rft.aulast=Wilson&rft.aufirst=Stephen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Advisory Committees: Regulatory Policy Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754278738; 5828881 JF - 46th Annual Meeting of the Drug Information Association AU - Warner, Jill Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advisory committees KW - FDA KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Advisory+Committees%3A+Regulatory+Policy+Update&rft.au=Warner%2C+Jill&rft.aulast=Warner&rft.aufirst=Jill&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Primer on Advertising and Promotion T2 - 46th Annual Meeting of the Drug Information Association AN - 754278646; 5828858 JF - 46th Annual Meeting of the Drug Information Association AU - Davis, Kristin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advertising KW - Primers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Primer+on+Advertising+and+Promotion&rft.au=Davis%2C+Kristin&rft.aulast=Davis&rft.aufirst=Kristin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US Regulatory Trends in GCP Compliance T2 - 46th Annual Meeting of the Drug Information Association AN - 754277516; 5829553 JF - 46th Annual Meeting of the Drug Information Association AU - Purohit-Sheth, Tejashri Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+Regulatory+Trends+in+GCP+Compliance&rft.au=Purohit-Sheth%2C+Tejashri&rft.aulast=Purohit-Sheth&rft.aufirst=Tejashri&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Collaborative Development of Analytical Tools: Streamlining Analysis of Clinical Trial Data T2 - 46th Annual Meeting of the Drug Information Association AN - 754277434; 5829570 JF - 46th Annual Meeting of the Drug Information Association AU - Soukup, Mat Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Collaborative+Development+of+Analytical+Tools%3A+Streamlining+Analysis+of+Clinical+Trial+Data&rft.au=Soukup%2C+Mat&rft.aulast=Soukup&rft.aufirst=Mat&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reflecting on ADaM from a Reviewer's Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754277145; 5829527 JF - 46th Annual Meeting of the Drug Information Association AU - Mele, Joy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Reflecting+on+ADaM+from+a+Reviewer%27s+Perspective&rft.au=Mele%2C+Joy&rft.aulast=Mele&rft.aufirst=Joy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Overview of Marketed Unapproved Drugs: Safety and Effi cacy Issues, Compliance Policy Guide, and Enforcement Actions T2 - 46th Annual Meeting of the Drug Information Association AN - 754276665; 5829465 JF - 46th Annual Meeting of the Drug Information Association AU - Mehta, Rikin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - Drugs KW - Reviews KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Overview+of+Marketed+Unapproved+Drugs%3A+Safety+and+Effi+cacy+Issues%2C+Compliance+Policy+Guide%2C+and+Enforcement+Actions&rft.au=Mehta%2C+Rikin&rft.aulast=Mehta&rft.aufirst=Rikin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Path from Scoping to Integrated Review for Genomic Data T2 - 46th Annual Meeting of the Drug Information Association AN - 754276635; 5829461 JF - 46th Annual Meeting of the Drug Information Association AU - Pacanowski, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Reviews KW - Data processing KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Path+from+Scoping+to+Integrated+Review+for+Genomic+Data&rft.au=Pacanowski%2C+Michael&rft.aulast=Pacanowski&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Impact of New Comparative Eff ective Requirements T2 - 46th Annual Meeting of the Drug Information Association AN - 754276601; 5829157 JF - 46th Annual Meeting of the Drug Information Association AU - Woodcock, Janet Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Impact+of+New+Comparative+Eff+ective+Requirements&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pharmacogenetics, Regulatory Science, and the Advancement of Personalized Health T2 - 46th Annual Meeting of the Drug Information Association AN - 754276586; 5829460 JF - 46th Annual Meeting of the Drug Information Association AU - Zineh, Issam Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Pharmacogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Pharmacogenetics%2C+Regulatory+Science%2C+and+the+Advancement+of+Personalized+Health&rft.au=Zineh%2C+Issam&rft.aulast=Zineh&rft.aufirst=Issam&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Fda'S Clinical Reviewer'S Perspective on Csr Safety Narratives T2 - 46th Annual Meeting of the Drug Information Association AN - 754276354; 5829215 JF - 46th Annual Meeting of the Drug Information Association AU - Chazin, Howard Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Fda%27S+Clinical+Reviewer%27S+Perspective+on+Csr+Safety+Narratives&rft.au=Chazin%2C+Howard&rft.aulast=Chazin&rft.aufirst=Howard&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Special Considerations in Life Science Criminal Investigations T2 - 46th Annual Meeting of the Drug Information Association AN - 754276310; 5829211 JF - 46th Annual Meeting of the Drug Information Association AU - Watson, Glenn Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Special+Considerations+in+Life+Science+Criminal+Investigations&rft.au=Watson%2C+Glenn&rft.aulast=Watson&rft.aufirst=Glenn&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Qbd Moving Forward: Opportunities and Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754276103; 5829186 JF - 46th Annual Meeting of the Drug Information Association AU - Winkle, Helen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Qbd+Moving+Forward%3A+Opportunities+and+Challenges&rft.au=Winkle%2C+Helen&rft.aulast=Winkle&rft.aufirst=Helen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fda Evaluation of Pro Measures for Regulatory Qualifi Cation to Support Claims T2 - 46th Annual Meeting of the Drug Information Association AN - 754276014; 5828834 JF - 46th Annual Meeting of the Drug Information Association AU - Papadopoulos, Elektra Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Cations KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Fda+Evaluation+of+Pro+Measures+for+Regulatory+Qualifi+Cation+to+Support+Claims&rft.au=Papadopoulos%2C+Elektra&rft.aulast=Papadopoulos&rft.aufirst=Elektra&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Cmc Reviewer'S Perspective on the Quality Overall Summary and Module 3 T2 - 46th Annual Meeting of the Drug Information Association AN - 754275770; 5829078 JF - 46th Annual Meeting of the Drug Information Association AU - Shaw, Arthur Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Cmc+Reviewer%27S+Perspective+on+the+Quality+Overall+Summary+and+Module+3&rft.au=Shaw%2C+Arthur&rft.aulast=Shaw&rft.aufirst=Arthur&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Some Regulatory Experiences in Multiregional Clinical Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754275732; 5828831 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H M Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Some+Regulatory+Experiences+in+Multiregional+Clinical+Trials&rft.au=Hung%2C+H+M&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug Master Files: An FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274887; 5829539 JF - 46th Annual Meeting of the Drug Information Association AU - Shaw, Arthur Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug+Master+Files%3A+An+FDA+Perspective&rft.au=Shaw%2C+Arthur&rft.aulast=Shaw&rft.aufirst=Arthur&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Opportunity and Challenges: Regulatory Pathway for Follow-on Biologics in Asia T2 - 46th Annual Meeting of the Drug Information Association AN - 754274819; 5829330 JF - 46th Annual Meeting of the Drug Information Association AU - Tzou, Meir-Chyun Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Asia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Opportunity+and+Challenges%3A+Regulatory+Pathway+for+Follow-on+Biologics+in+Asia&rft.au=Tzou%2C+Meir-Chyun&rft.aulast=Tzou&rft.aufirst=Meir-Chyun&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Statistical Considerations in Design and Analysis of Multiregional Clinical Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754274776; 5829325 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Statistical+Considerations+in+Design+and+Analysis+of+Multiregional+Clinical+Trials&rft.au=Hung%2C+H&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA's View on PDUFA: Progress and Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754274771; 5829388 JF - 46th Annual Meeting of the Drug Information Association AU - Mullin, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA%27s+View+on+PDUFA%3A+Progress+and+Challenges&rft.au=Mullin%2C+Theresa&rft.aulast=Mullin&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Food and Drug Administration Guidance for Industry on Drug-Diagnostic Co-Development T2 - 46th Annual Meeting of the Drug Information Association AN - 754274673; 5829318 JF - 46th Annual Meeting of the Drug Information Association AU - Seyfert-Margolis, Vicki Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Food+and+Drug+Administration+Guidance+for+Industry+on+Drug-Diagnostic+Co-Development&rft.au=Seyfert-Margolis%2C+Vicki&rft.aulast=Seyfert-Margolis&rft.aufirst=Vicki&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Update--Food Irradiation T2 - 2010 Annual Meeting of the American Nuclear Society AN - 754274654; 5845512 JF - 2010 Annual Meeting of the American Nuclear Society AU - Highbarger, Lane Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Irradiation KW - Radiation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Nuclear+Society&rft.atitle=Regulatory+Update--Food+Irradiation&rft.au=Highbarger%2C+Lane&rft.aulast=Highbarger&rft.aufirst=Lane&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Nuclear+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.new.ans.org/meetings/file/151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Training Considerations for Complying with 45 Cfr Part 46 T2 - 46th Annual Meeting of the Drug Information Association AN - 754274597; 5829327 JF - 46th Annual Meeting of the Drug Information Association AU - Yoder, Freda Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Training+Considerations+for+Complying+with+45+Cfr+Part+46&rft.au=Yoder%2C+Freda&rft.aulast=Yoder&rft.aufirst=Freda&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Current Quality Challenges: Potential Qbd Solutions - Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274564; 5829336 JF - 46th Annual Meeting of the Drug Information Association AU - Jenkins, John Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Current+Quality+Challenges%3A+Potential+Qbd+Solutions+-+Regulatory+Perspective&rft.au=Jenkins%2C+John&rft.aulast=Jenkins&rft.aufirst=John&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Rems: Fda Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274509; 5829312 JF - 46th Annual Meeting of the Drug Information Association AU - Kashoki, Mwango Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Rems%3A+Fda+Perspective&rft.au=Kashoki%2C+Mwango&rft.aulast=Kashoki&rft.aufirst=Mwango&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Food and Drug Administration Point of View T2 - 46th Annual Meeting of the Drug Information Association AN - 754274351; 5829285 JF - 46th Annual Meeting of the Drug Information Association AU - Mullin, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Food+and+Drug+Administration+Point+of+View&rft.au=Mullin%2C+Theresa&rft.aulast=Mullin&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - CDISC Content to HL7 Standard Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754273245; 5829015 JF - 46th Annual Meeting of the Drug Information Association AU - Levine, Jonathan Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754273245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=CDISC+Content+to+HL7+Standard+Update&rft.au=Levine%2C+Jonathan&rft.aulast=Levine&rft.aufirst=Jonathan&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Preapproval Inspections Field Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754273056; 5828972 JF - 46th Annual Meeting of the Drug Information Association AU - Sosa, Myriam Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Inspection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754273056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Preapproval+Inspections+Field+Perspective&rft.au=Sosa%2C+Myriam&rft.aulast=Sosa&rft.aufirst=Myriam&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Synthesizing and Communicating Available Data on Drug Use During Pregnancy and Lactation T2 - 46th Annual Meeting of the Drug Information Association AN - 754272829; 5829421 JF - 46th Annual Meeting of the Drug Information Association AU - Sahin, Leyla Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Pregnancy KW - Drug abuse KW - Data processing KW - Lactation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Synthesizing+and+Communicating+Available+Data+on+Drug+Use+During+Pregnancy+and+Lactation&rft.au=Sahin%2C+Leyla&rft.aulast=Sahin&rft.aufirst=Leyla&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biomarkers in Clinical Drug Development: Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754272773; 5829396 JF - 46th Annual Meeting of the Drug Information Association AU - Targum, Shari AU - Wang, Sue-Jane Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Bioindicators KW - Drug development KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Biomarkers+in+Clinical+Drug+Development%3A+Regulatory+Perspective&rft.au=Targum%2C+Shari%3BWang%2C+Sue-Jane&rft.aulast=Targum&rft.aufirst=Shari&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Usan and Inn T2 - 46th Annual Meeting of the Drug Information Association AN - 754272712; 5828967 JF - 46th Annual Meeting of the Drug Information Association AU - Lewis, David Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Usan+and+Inn&rft.au=Lewis%2C+David&rft.aulast=Lewis&rft.aufirst=David&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Toxicological Perspectives of Nonclinical Testing in Botanical Drug Development T2 - 46th Annual Meeting of the Drug Information Association AN - 754272710; 5828932 JF - 46th Annual Meeting of the Drug Information Association AU - Wu, Kuei-Meng Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Toxicological+Perspectives+of+Nonclinical+Testing+in+Botanical+Drug+Development&rft.au=Wu%2C+Kuei-Meng&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enforcement Update from Cber T2 - 46th Annual Meeting of the Drug Information Association AN - 754272625; 5828963 JF - 46th Annual Meeting of the Drug Information Association AU - Ibarra Pratt, Ele Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Surveillance and enforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Enforcement+Update+from+Cber&rft.au=Ibarra+Pratt%2C+Ele&rft.aulast=Ibarra+Pratt&rft.aufirst=Ele&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Myths and Truths about Regulatory Requirements for Co-Development of Drug-Diagnostic Pairs T2 - 46th Annual Meeting of the Drug Information Association AN - 754272548; 5829317 JF - 46th Annual Meeting of the Drug Information Association AU - Mansfield, Elizabeth Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Myths+and+Truths+about+Regulatory+Requirements+for+Co-Development+of+Drug-Diagnostic+Pairs&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Could We Do Better in Preparation of 2009 H1N1 Pandemic Vaccines? T2 - 46th Annual Meeting of the Drug Information Association AN - 754272422; 5828890 JF - 46th Annual Meeting of the Drug Information Association AU - Ye, Zhiping Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Vaccines KW - Pandemics KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Could+We+Do+Better+in+Preparation+of+2009+H1N1+Pandemic+Vaccines%3F&rft.au=Ye%2C+Zhiping&rft.aulast=Ye&rft.aufirst=Zhiping&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Supply Chain Security: Home and Abroad T2 - 46th Annual Meeting of the Drug Information Association AN - 754272297; 5828945 JF - 46th Annual Meeting of the Drug Information Association AU - Bernstein, Ilisa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Security KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Supply+Chain+Security%3A+Home+and+Abroad&rft.au=Bernstein%2C+Ilisa&rft.aulast=Bernstein&rft.aufirst=Ilisa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA's Draft Guidance for Industry on Noninferiority Trials: Why It Is Needed and Key Features T2 - 46th Annual Meeting of the Drug Information Association AN - 754272288; 5828886 JF - 46th Annual Meeting of the Drug Information Association AU - O'Neill, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA%27s+Draft+Guidance+for+Industry+on+Noninferiority+Trials%3A+Why+It+Is+Needed+and+Key+Features&rft.au=O%27Neill%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Advisory Committees: Offi ce of New Drugs Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754272235; 5828882 JF - 46th Annual Meeting of the Drug Information Association AU - Justice, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advisory committees KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Advisory+Committees%3A+Offi+ce+of+New+Drugs+Perspective&rft.au=Justice%2C+Robert&rft.aulast=Justice&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Electronic Medical Data, Public Health Decisions, and Statisticians: An FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754271377; 5829044 JF - 46th Annual Meeting of the Drug Information Association AU - O'Neill, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Statisticians KW - Public health KW - FDA KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Electronic+Medical+Data%2C+Public+Health+Decisions%2C+and+Statisticians%3A+An+FDA+Perspective&rft.au=O%27Neill%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - RPS Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754271240; 5829014 JF - 46th Annual Meeting of the Drug Information Association AU - Garvey, Patricia Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=RPS+Update&rft.au=Garvey%2C+Patricia&rft.aulast=Garvey&rft.aufirst=Patricia&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Chemistry, Manufacturing, and Controls Information Recommended for a Botanical Drug Product T2 - 46th Annual Meeting of the Drug Information Association AN - 754270745; 5828933 JF - 46th Annual Meeting of the Drug Information Association AU - Agarwal, Rajiv Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Chemistry%2C+Manufacturing%2C+and+Controls+Information+Recommended+for+a+Botanical+Drug+Product&rft.au=Agarwal%2C+Rajiv&rft.aulast=Agarwal&rft.aufirst=Rajiv&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Current Regulatory Jurisdiction, Procedures, and Considerations T2 - 46th Annual Meeting of the Drug Information Association AN - 754270493; 5829409 JF - 46th Annual Meeting of the Drug Information Association AU - Folkendt, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Jurisdiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Current+Regulatory+Jurisdiction%2C+Procedures%2C+and+Considerations&rft.au=Folkendt%2C+Michael&rft.aulast=Folkendt&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Personalized Medicine: Food and Drug Administration Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754270275; 5829320 JF - 46th Annual Meeting of the Drug Information Association AU - Kalush, Francis Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Personalized+Medicine%3A+Food+and+Drug+Administration+Perspective&rft.au=Kalush%2C+Francis&rft.aulast=Kalush&rft.aufirst=Francis&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of Spontaneous Reporting in the Evaluation of Pediatric Drug Safety T2 - 46th Annual Meeting of the Drug Information Association AN - 754270204; 5829295 JF - 46th Annual Meeting of the Drug Information Association AU - McMahon, Ann Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drug development KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Role+of+Spontaneous+Reporting+in+the+Evaluation+of+Pediatric+Drug+Safety&rft.au=McMahon%2C+Ann&rft.aulast=McMahon&rft.aufirst=Ann&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fda Point of View T2 - 46th Annual Meeting of the Drug Information Association AN - 754269850; 5829202 JF - 46th Annual Meeting of the Drug Information Association AU - Pan, Gerald Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Fda+Point+of+View&rft.au=Pan%2C+Gerald&rft.aulast=Pan&rft.aufirst=Gerald&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754269531; 5829081 JF - 46th Annual Meeting of the Drug Information Association AU - Ball, Leslie Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Perspective&rft.au=Ball%2C+Leslie&rft.aulast=Ball&rft.aufirst=Leslie&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Ddmac Direct-to-Consumer Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754268852; 5828984 JF - 46th Annual Meeting of the Drug Information Association AU - Sullivan, Helen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Ddmac+Direct-to-Consumer+Update&rft.au=Sullivan%2C+Helen&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pharmacognosy Review of Botanical Drug Applications T2 - 46th Annual Meeting of the Drug Information Association AN - 754268610; 5828931 JF - 46th Annual Meeting of the Drug Information Association AU - Dou, Jinhui Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Reviews KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Pharmacognosy+Review+of+Botanical+Drug+Applications&rft.au=Dou%2C+Jinhui&rft.aulast=Dou&rft.aufirst=Jinhui&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - What Are the Key Regulatory Principles That Will Give Confi Dence to Regulators for Acceptance of Foreign Clinical Data to Be Used as Pivotal in the Assessment of New Medicines for Approval? T2 - 46th Annual Meeting of the Drug Information Association AN - 754268360; 5829307 JF - 46th Annual Meeting of the Drug Information Association AU - Lumpkin, Murray Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=What+Are+the+Key+Regulatory+Principles+That+Will+Give+Confi+Dence+to+Regulators+for+Acceptance+of+Foreign+Clinical+Data+to+Be+Used+as+Pivotal+in+the+Assessment+of+New+Medicines+for+Approval%3F&rft.au=Lumpkin%2C+Murray&rft.aulast=Lumpkin&rft.aufirst=Murray&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Federal Comparative Effectiveness Research: Current and Future Directions T2 - 46th Annual Meeting of the Drug Information Association AN - 754266848; 5829037 JF - 46th Annual Meeting of the Drug Information Association AU - Clancy, Carolyn Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Federal+Comparative+Effectiveness+Research%3A+Current+and+Future+Directions&rft.au=Clancy%2C+Carolyn&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Manufacturing Facility Information Needed in the Drug Application T2 - 46th Annual Meeting of the Drug Information Association AN - 754266647; 5828973 JF - 46th Annual Meeting of the Drug Information Association AU - Folkendt, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - Manufacturing industry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Manufacturing+Facility+Information+Needed+in+the+Drug+Application&rft.au=Folkendt%2C+Michael&rft.aulast=Folkendt&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Making a Difference: A Case Study on Developing Effective Training T2 - 2010 Conference and Exposition of the American Society of Safety Engineers on Professional Development AN - 754265486; 5823908 JF - 2010 Conference and Exposition of the American Society of Safety Engineers on Professional Development AU - Cullen, Elaine Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Case studies KW - Training KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Society+of+Safety+Engineers+on+Professional+Development&rft.atitle=Making+a+Difference%3A+A+Case+Study+on+Developing+Effective+Training&rft.au=Cullen%2C+Elaine&rft.aulast=Cullen&rft.aufirst=Elaine&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Society+of+Safety+Engineers+on+Professional+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.asse.org/education/pdc10/docs/ASSE-SAFETY-2010-60-pg.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Supplier Quality Management: A Risk-based Approach T2 - 46th Annual Meeting of the Drug Information Association AN - 754263265; 5829485 JF - 46th Annual Meeting of the Drug Information Association AU - Wolfgang, Steven Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Risks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Supplier+Quality+Management%3A+A+Risk-based+Approach&rft.au=Wolfgang%2C+Steven&rft.aulast=Wolfgang&rft.aufirst=Steven&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754262809; 5829135 JF - 46th Annual Meeting of the Drug Information Association AU - Scanlon, James Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+Perspective&rft.au=Scanlon%2C+James&rft.aulast=Scanlon&rft.aufirst=James&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Point of View from the FDA T2 - 46th Annual Meeting of the Drug Information Association AN - 754262419; 5828825 JF - 46th Annual Meeting of the Drug Information Association AU - Love, Patricia Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Point+of+View+from+the+FDA&rft.au=Love%2C+Patricia&rft.aulast=Love&rft.aufirst=Patricia&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US GCP Requirements for Global Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754261495; 5829370 JF - 46th Annual Meeting of the Drug Information Association AU - Mulinde, Jean Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+GCP+Requirements+for+Global+Trials&rft.au=Mulinde%2C+Jean&rft.aulast=Mulinde&rft.aufirst=Jean&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Information Uniformity: Essential for Evaluation and Effi ciency T2 - 46th Annual Meeting of the Drug Information Association AN - 754261204; 5829051 JF - 46th Annual Meeting of the Drug Information Association AU - Fitzmaurice, J Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Health+Information+Uniformity%3A+Essential+for+Evaluation+and+Effi+ciency&rft.au=Fitzmaurice%2C+J&rft.aulast=Fitzmaurice&rft.aufirst=J&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Statistical Reviewer's Perspective: Making Sure that Everything is Ready to Go on Day 1 T2 - 46th Annual Meeting of the Drug Information Association AN - 754254761; 5829277 JF - 46th Annual Meeting of the Drug Information Association AU - Zhou, Feng Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Statistical+Reviewer%27s+Perspective%3A+Making+Sure+that+Everything+is+Ready+to+Go+on+Day+1&rft.au=Zhou%2C+Feng&rft.aulast=Zhou&rft.aufirst=Feng&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Establishment of the Taiwan Food and Drug Administration: Future Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754254241; 5829033 JF - 46th Annual Meeting of the Drug Information Association AU - Kang, Jaw-Jou Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Taiwan KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Establishment+of+the+Taiwan+Food+and+Drug+Administration%3A+Future+Perspective&rft.au=Kang%2C+Jaw-Jou&rft.aulast=Kang&rft.aufirst=Jaw-Jou&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The role of ethnobotany in policy and commerce T2 - 51st Annual Meeting of the Society for Economic Botany AN - 754316704; 5872258 JF - 51st Annual Meeting of the Society for Economic Botany AU - Casper, Steven Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Ethnobotany KW - Policies KW - Commerce KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754316704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+for+Economic+Botany&rft.atitle=The+role+of+ethnobotany+in+policy+and+commerce&rft.au=Casper%2C+Steven&rft.aulast=Casper&rft.aufirst=Steven&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+for+Economic+Botany&rft.issn=&rft_id=info:doi/ L2 - http://www.econbot.org/_organization_/07_annual_meetings/meetings_by_y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Early Postnatal Anesthesia and Long Lasting Cognitive Deficits in Rhesus Monkeys T2 - 26th International Neurotoxicology Conference AN - 754308765; 5864458 JF - 26th International Neurotoxicology Conference AU - Paule, M AU - Li, M. AU - Zou, X AU - Slikker Jr, W AU - Wang, C AU - Hotchkiss, C AU - Hanig, J Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Anesthesia KW - Cognitive ability KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754308765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Neurotoxicology+Conference&rft.atitle=Early+Postnatal+Anesthesia+and+Long+Lasting+Cognitive+Deficits+in+Rhesus+Monkeys&rft.au=Paule%2C+M%3BLi%2C+M.%3BZou%2C+X%3BSlikker+Jr%2C+W%3BWang%2C+C%3BHotchkiss%2C+C%3BHanig%2C+J&rft.aulast=Paule&rft.aufirst=M&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Neurotoxicology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.neurotoxicology.com/conf2009/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effect of Chronic MPTP Administration on Glycolysis and TCA Cycle Pathways in Mouse Model of Parkinson's Disease T2 - 26th International Neurotoxicology Conference AN - 754308204; 5864454 JF - 26th International Neurotoxicology Conference AU - Sonko, Bakary AU - Schmitt, Tom AU - Beger, Richard AU - Sakar, Sumit AU - Syed, Ali AU - Boros, Laszlo Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Parkinson's disease KW - Animal models KW - Movement disorders KW - Neurodegenerative diseases KW - Tricarboxylic acid cycle KW - Glycolysis KW - MPTP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754308204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Neurotoxicology+Conference&rft.atitle=Effect+of+Chronic+MPTP+Administration+on+Glycolysis+and+TCA+Cycle+Pathways+in+Mouse+Model+of+Parkinson%27s+Disease&rft.au=Sonko%2C+Bakary%3BSchmitt%2C+Tom%3BBeger%2C+Richard%3BSakar%2C+Sumit%3BSyed%2C+Ali%3BBoros%2C+Laszlo&rft.aulast=Sonko&rft.aufirst=Bakary&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Neurotoxicology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.neurotoxicology.com/conf2009/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Considerations for Organ Dysfunction Studies T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839658636; 5907180 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Huang, Shiew-Mei Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Organs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Regulatory+Considerations+for+Organ+Dysfunction+Studies&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Career Options in Government T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839641321; 5903975 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Pazdur, Richard Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Career+Options+in+Government&rft.au=Pazdur%2C+Richard&rft.aulast=Pazdur&rft.aufirst=Richard&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Prevention of Mental Disorders and Substance Abuse Among Children, Youth and Young Adults T2 - 2010 Conference of the Institute on Social Exclusion (ISE 2010) AN - 754299168; 5858890 JF - 2010 Conference of the Institute on Social Exclusion (ISE 2010) AU - Thompson, Kenneth Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 KW - Mental disorders KW - Prevention KW - Children KW - Young adults KW - Substance abuse KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754299168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+of+the+Institute+on+Social+Exclusion+%28ISE+2010%29&rft.atitle=Prevention+of+Mental+Disorders+and+Substance+Abuse+Among+Children%2C+Youth+and+Young+Adults&rft.au=Thompson%2C+Kenneth&rft.aulast=Thompson&rft.aufirst=Kenneth&rft.date=2010-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+of+the+Institute+on+Social+Exclusion+%28ISE+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adler.edu/about/sdomh2010agenda.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Age and Sex-Related Differences in Hepatic Gene Expression during the Rat Life Cycle T2 - 2010 Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2010) AN - 754292378; 5842287 JF - 2010 Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2010) AU - Kwekel, Joshua Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 KW - Life cycle KW - Age KW - Gene expression KW - Sex differences KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754292378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2010%29&rft.atitle=Age+and+Sex-Related+Differences+in+Hepatic+Gene+Expression+during+the+Rat+Life+Cycle&rft.au=Kwekel%2C+Joshua&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2010-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://data.memberclicks.com/site/ossd/OSSD%202010%20Scientific%20Prog LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice AN - 746311486; 13205726 AB - Debate exists as to whether welding fume is carcinogenic, but epidemiological evidence suggests that welders are an at risk population for the development of lung cancer. Recently, we found that exposure to welding fume caused an acutely greater and prolonged lung inflammatory response in lung tumor susceptible A/J versus resistant C57BL/6J (B6) mice and a trend for increased tumor incidence after stainless steel (SS) fume exposure. Here, our objective was to examine potential strain-dependent differences in the regulation and resolution of the lung inflammatory response induced by carcinogenic (Cr and Ni abundant) or non-carcinogenic (iron abundant) metal-containing welding fumes at the transcriptome level. Mice were exposed four times by pharyngeal aspiration to 5 mg/kg iron abundant gas metal arc-mild steel (GMA-MS), Cr and Ni abundant GMA-SS fume or vehicle and were euthanized 4 and 16 weeks after the last exposure. Whole lung microarray using Illumina Mouse Ref-8 expression beadchips was done. Overall, we found that tumor susceptibility was associated with a more marked transcriptional response to both GMA-MS and -SS welding fumes. Also, Ingenuity Pathway Analysis revealed that gene regulation and expression in the top molecular networks differed between the strains at both time points post-exposure. Interestingly, a common finding between the strains was that GMA-MS fume exposure altered behavioral gene networks. In contrast, GMA-SS fume exposure chronically upregulated chemotactic and immunomodulatory genes such as CCL3, CCL4, CXCL2, and MMP12 in the A/J strain. In the GMA-SS-exposed B6 mouse, genes that initially downregulated cellular movement, hematological system development/function and immune response were involved at both time points post-exposure. However, at 16 weeks, a transcriptional switch to an upregulation for neutrophil chemotactic genes was found and included genes such as S100A8, S100A9 and MMP9. Collectively, our results demonstrate that lung tumor susceptibility may predispose the A/J strain to a prolonged dysregulation of immunomodulatory genes, thereby delaying the recovery from welding fume-induced lung inflammation. Additionally, our results provide unique insight into strain- and welding fume-dependent genetic factors involved in the lung response to welding fume. JF - Respiratory Research AU - Zeidler-Erdely, Patti C AU - Kashon, Michael L AU - Li, Shengqiao AU - Antonini, James M AD - Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, 26505, USA Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 SP - 70 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 1 SN - 1465-9921, 1465-9921 KW - Toxicology Abstracts; Immunology Abstracts KW - Genetic factors KW - Pharynx KW - CCL4 protein KW - Heavy metals KW - Development KW - Immunomodulation KW - DNA microarrays KW - Gene expression KW - Welding KW - Steel KW - Lung cancer KW - Fumes KW - Chromium KW - CCL3 protein KW - Leukocytes (neutrophilic) KW - Transcription KW - Tumors KW - Inflammation KW - Lung KW - Gene regulation KW - Gelatinase B KW - Immune response KW - Iron KW - stainless steel KW - F 06915:Cancer Immunology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746311486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+Research&rft.atitle=Response+of+the+mouse+lung+transcriptome+to+welding+fume%3A+effects+of+stainless+and+mild+steel+fumes+on+lung+gene+expression+in+A%2FJ+and+C57BL%2F6J+mice&rft.au=Zeidler-Erdely%2C+Patti+C%3BKashon%2C+Michael+L%3BLi%2C+Shengqiao%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2010-06-03&rft.volume=11&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Respiratory+Research&rft.issn=14659921&rft_id=info:doi/10.1186%2F1465-9921-11-70 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genetic factors; CCL4 protein; Pharynx; Fumes; Chromium; Heavy metals; CCL3 protein; Leukocytes (neutrophilic); Transcription; Development; Tumors; DNA microarrays; Immunomodulation; Inflammation; Gene expression; Lung; Gene regulation; Welding; Immune response; Steel; Gelatinase B; Iron; Lung cancer; stainless steel DO - http://dx.doi.org/10.1186/1465-9921-11-70 ER - TY - JOUR T1 - Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies AN - 744701515; 13114147 AB - Background The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. Methods We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P sub(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P sub(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P sub(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Conclusions Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. JF - Journal of the National Cancer Institute AU - Zhang, Xuehong AU - Albanes, Demetrius AU - Beeson, WLawrence AU - van den Brandt, Piet A AU - Buring, Julie E AU - Flood, Andrew AU - Freudenheim, Jo L AU - Giovannucci, Edward L AU - Goldbohm, RAlexandra AU - Jaceldo-Siegl, Karen AU - Jacobs, Eric J AU - Krogh, Vittorio AU - Larsson, Susanna C AU - Marshall, James R AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Robien, Kim AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Sieri, Sabina AU - Spiegelman, Donna AU - Virtamo, Jarmo AU - Wolk, Alicja AU - Willett, Walter C AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Department of Nutrition (XZ, ELG, WCW, SAS-W), Department of Epidemiology (XZ, JEB, ELG, DS, WCW, SAS-W), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Nutritional Epidemiology Branch (DA) and Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (AS), National Cancer Institute, National Institute of Health, Bethesda, MD; The Center for Health Research, Loma Linda University School of Public Health, Loma Linda, CA (WLB, KJ-S); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands (PAvdB); Division of Preventive Medicine, Department of Medicine (JEB, SMZ) and Channing Laboratory, Department of Medicine (ELG, WCW), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY (JLF); Department of Foo, pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 SP - 771 EP - 783 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 11 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Coffee KW - Physical activity KW - Statistical analysis KW - tumors KW - tea KW - Models KW - Smoking KW - body mass KW - Tea KW - physical activity KW - Ethanol KW - Sex KW - Alcohol KW - Data processing KW - Beverages KW - coffee KW - Tumors KW - Colon cancer KW - Cancer KW - Drinking behavior KW - Body mass index KW - X 24380:Social Poisons & Drug Abuse KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744701515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Risk+of+Colon+Cancer+and+Coffee%2C+Tea%2C+and+Sugar-Sweetened+Soft+Drink+Intake%3A+Pooled+Analysis+of+Prospective+Cohort+Studies&rft.au=Zhang%2C+Xuehong%3BAlbanes%2C+Demetrius%3BBeeson%2C+WLawrence%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BFlood%2C+Andrew%3BFreudenheim%2C+Jo+L%3BGiovannucci%2C+Edward+L%3BGoldbohm%2C+RAlexandra%3BJaceldo-Siegl%2C+Karen%3BJacobs%2C+Eric+J%3BKrogh%2C+Vittorio%3BLarsson%2C+Susanna+C%3BMarshall%2C+James+R%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BRobien%2C+Kim%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSieri%2C+Sabina%3BSpiegelman%2C+Donna%3BVirtamo%2C+Jarmo%3BWolk%2C+Alicja%3BWillett%2C+Walter+C%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Zhang&rft.aufirst=Xuehong&rft.date=2010-06-02&rft.volume=102&rft.issue=11&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Coffee; Risk assessment; Beverages; Data processing; Physical activity; Statistical analysis; Colon cancer; Tumors; Models; Smoking; Tea; Drinking behavior; Body mass index; Sex; Ethanol; Alcohol; body mass; coffee; tumors; physical activity; tea; Cancer DO - http://dx.doi.org/10.1093/jnci/djq107 ER - TY - JOUR T1 - Small noncoding RNAs: Biogenesis, function, and emerging significance in toxicology AN - 883022878; 15242294 AB - In recent years, the discovery of small ncRNAs (noncoding RNAs) has unveiled a slew of powerful riboregulators of gene expression. So far, many different types of small ncRNAs have been described. Of these, miRNAs (microRNAs), siRNAs (small interfering RNAs), and piRNAs (Piwi-interacting RNAs) have been studied in more detail. A significant fraction of genes in most organisms and tissues is targets of these small ncRNAs. Because these tiny RNAs are turning out to be important regulators of gene and genome expression, their aberrant expression profiles are expected to be associated with cellular dysfunction and disease. In fact, an ever-increasing number of studies have implicated miRNAs and siRNAs in human health and disease ranging from metabolic disorders to diseases of various organ systems as well as various forms of cancer. Nevertheless, despite the flurry of research on these small ncRNAs, many aspects of their biology still remain to be understood. The following discussion focuses on some aspects of the biogenesis and function of small ncRNAs with major emphasis on miRNAs since these are the most widespread endogenous small ncRNAs that have been called 'micromanagers' of gene expression. Their emerging significance in toxicology is also discussed. [copy 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:195-216, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20325 JF - Journal of Biochemical and Molecular Toxicology AU - Choudhuri, Supratim Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 195 EP - 216 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 3 SN - 1099-0461, 1099-0461 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Environment Abstracts; Toxicology Abstracts KW - Biochemistry KW - Cancer KW - Gene expression KW - Genomes KW - Internet KW - Metabolic disorders KW - Organs KW - Toxicology KW - metabolic disorders KW - miRNA KW - non-coding RNA KW - siRNA KW - X 24490:Other KW - N 14830:RNA KW - W 30965:Miscellaneous, Reviews KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883022878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=Small+noncoding+RNAs%3A+Biogenesis%2C+function%2C+and+emerging+significance+in+toxicology&rft.au=Choudhuri%2C+Supratim&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2010-06-01&rft.volume=24&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10990461&rft_id=info:doi/10.1002%2Fjbt.20325 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbt.20325/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; siRNA; Metabolic disorders; miRNA; non-coding RNA; Cancer; Internet; metabolic disorders; Biochemistry; Organs; Toxicology DO - http://dx.doi.org/10.1002/jbt.20325 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHROMIUM PICOLINATE MONOHYDRATE (CAS NO. 27882-76-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) AN - 878891980; 20725156 AB - Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). While chromium VI has been shown to cause cancer in other animal studies, chromium III is an essential trace element and is ingested in food and dietary supplements. We gave feed containing 2,000, 10,000, or 50,000 parts per million (ppm) of chromium picolinate to groups of 50 male and female rats and mice for two years. Similar groups of animals were given feed with no chemical added and served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival of all exposed groups of animals was similar to their controls. The rate of adenomas of the preputial gland was greater in male rats receiving 10,000 ppm chromium picolinate than in the control group. We conclude that the occurence of preputial gland adenomas in one group of male rats was possibly associated with exposure to chromium picolinate. We conclude that chromium picolinate did not cause cancer in female rats or in male or female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 EP - 194 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Picolinic Acids KW - picolinic acid KW - Toxicology KW - Rodents KW - Chromium compounds KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Picolinic Acids -- pharmacokinetics KW - Mice KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Picolinic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+CHROMIUM+PICOLINATE+MONOHYDRATE+%28CAS+NO.+27882-76-4%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878891978 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878891903 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683499 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=544&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 201