TY - GEN T1 - 15 Years of Fish Drug Approvals: A Success Story AN - 846767174 AB - Due to joint efforts by the aquaculture industry, government, academia, and drug companies, the fish drug arsenal grew over the last 15 years. Since 1995, FDA approved seven drugs and 14 different label claims for fish. A session at the 2010 World Aquaculture Society conference, held in San Diego, California, earlier this year, highlighted these drug approval successes. JF - FDA Veterinarian AU - McLean, Melanie, DVM Y1 - 2010/12/15/ PY - 2010 DA - 2010 Dec 15 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 3 KW - Veterinary Science KW - Fish KW - FDA approval KW - Aquaculture KW - Drugs KW - Fishing industry KW - San Diego California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/846767174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=15+Years+of+Fish+Drug+Approvals%3A+A+Success+Story&rft.au=McLean%2C+Melanie%2C+DVM&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-12-15&rft.volume=&rft.issue=3&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Dec 15, 2010 N1 - Last updated - 2011-06-21 ER - TY - JOUR T1 - Moving Forward in Human Cancer Risk Assessment AN - 1677921891; 15090549 AB - The current safety paradigm for assessing carcinogenic properties of drugs, cosmetics, industrial chemicals, and environmental exposures relies mainly on in vitro genotoxicity testing followed by 2-year rodent bioassays. This testing battery is extremely sensitive but has low specificity. Furthermore, rodent bioassays are associated with high costs, high animal burden, and limited predictive value for human risks. We provide a response to a growing appeal for a paradigm change in human cancer risk assessment. To facilitate development of a road map for this needed paradigm change in carcinogenicity testing, a workshop titled "Genomics in Cancer Risk Assessment" brought together toxicologists from academia and industry and government regulators and risk assessors from the United States and the European Union. Participants discussed the state-of-the-art in developing alternative testing strategies for carcinogenicity, with emphasis on potential contributions from omics technologies. The goal of human risk assessment is to decide whether a given exposure to an agent is acceptable to human health and to provide risk management measures based on evaluating and predicting the effects of exposures on human health. Although exciting progress is being made using genomics approaches, a new paradigm that uses these methods and human material when possible would provide mechanistic insights that may inform new predictive approaches (e.g., in vitro assays) and facilitate the development of genomics-derived biomarkers. Regulators appear to be willing to accept such approaches where use is clearly defined, evidence is strong, and approaches are qualified for regulatory use. JF - Environmental Health Perspectives AU - Paules, Richard S AU - Aubrecht, Jiri AU - Corvi, Raffaella AU - Garthoff, Bernward AU - Kleinjans, Jos C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 739 EP - 743 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 6 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - cancer KW - human KW - omics technologies KW - risk assessment KW - systems biology KW - Risk assessment KW - Risk KW - In vitro testing KW - Human KW - Exposure KW - Health KW - Cancer KW - Bioassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677921891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Moving+Forward+in+Human+Cancer+Risk+Assessment&rft.au=Paules%2C+Richard+S%3BAubrecht%2C+Jiri%3BCorvi%2C+Raffaella%3BGarthoff%2C+Bernward%3BKleinjans%2C+Jos+C&rft.aulast=Paules&rft.aufirst=Richard&rft.date=2010-12-13&rft.volume=119&rft.issue=6&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002735 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002735 ER - TY - JOUR T1 - Global Gene Expression Profiling of a Population Exposed to a Range of Benzene Levels AN - 1677904471; 15090571 AB - Benzene, an established cause of acute myeloid leukemia (AML), may also cause one or more lymphoid malignancies in humans. Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers. The goals of this study were to identify potential biomarkers of benzene exposure and/or early effects and to elucidate mechanisms relevant to risk of hematotoxicity, leukemia, and lymphoid malignancy in occupationally exposed individuals, many of whom were exposed to benzene levels & 1 ppm, the current U.S. occupational standard. We analyzed global gene expression in the peripheral blood mononuclear cells of 125 workers exposed to benzene levels ranging from & 1 ppm to > 10 ppm. Study design and analysis with a mixed-effects model minimized potential confounding and experimental variability. We observed highly significant widespread perturbation of gene expression at all exposure levels. The AML pathway was among the pathways most significantly associated with benzene exposure. Immune response pathways were associated with most exposure levels, potentially providing biological plausibility for an association between lymphoma and benzene exposure. We identified a 16-gene expression signature associated with all levels of benzene exposure. Our findings suggest that chronic benzene exposure, even at levels below the current U.S. occupational standard, perturbs many genes, biological processes, and pathways. These findings expand our understanding of the mechanisms by which benzene may induce hematotoxicity, leukemia, and lymphoma and reveal relevant potential biomarkers associated with a range of exposures. JF - Environmental Health Perspectives AU - McHale, Cliona M AU - Zhang, Luoping AU - Lan, Qing AU - Vermeulen, Roel AU - Li, Guilan AU - Hubbard, Alan E AU - Porter, Kristin E AU - Thomas, Reuben AU - Portier, Christopher J AU - Shen, Min AU - Rappaport, Stephen M AU - Yin, Songnian AU - Smith, Martyn T AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/12/13/ PY - 2010 DA - 2010 Dec 13 SP - 628 EP - 640 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 119 IS - 5 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - benzene KW - biomarker KW - human KW - microarray KW - transcriptomics KW - Gene expression KW - Pathways KW - Occupational KW - Exposure KW - Biological KW - Standards KW - Leukemias KW - Benzene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677904471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Gene+Expression+Profiling+of+a+Population+Exposed+to+a+Range+of+Benzene+Levels&rft.au=McHale%2C+Cliona+M%3BZhang%2C+Luoping%3BLan%2C+Qing%3BVermeulen%2C+Roel%3BLi%2C+Guilan%3BHubbard%2C+Alan+E%3BPorter%2C+Kristin+E%3BThomas%2C+Reuben%3BPortier%2C+Christopher+J%3BShen%2C+Min%3BRappaport%2C+Stephen+M%3BYin%2C+Songnian%3BSmith%2C+Martyn+T%3BRothman%2C+Nathaniel&rft.aulast=McHale&rft.aufirst=Cliona&rft.date=2010-12-13&rft.volume=119&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002546 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002546 ER - TY - JOUR T1 - Survey and risk assessment of trace elements in foods from Taiwan containing red mould rice (Monascus) by ICP-MS AN - 907180009; 15716368 AB - The concentrations of seven trace elements (As, Cd, Cr, Pb, Se, Cu and Zn) in 93 red mould rice (Monascus) food samples in Taipei, Taiwan, were determined by inductively coupled plasma-mass spectrometry (ICP-MS) after wet digestion. The results, calculated in mg kg-1 (wet weight) for each sample, revealed the general scenario of food safety in Taiwan: As (0.005-12.04), Cd (<0.0005-2.22), Cr (0.014-6.95), Cu (0.012-8.70), Pb (0.001-0.64), Se (<0.001-1.29) and Zn (0.020-67.02). Three food samples were identified with As concentrations higher than regulatory limits: a dietary supplement sample and a seaweed sample with As concentrations that exceeded the limit of Taiwan's health food standard of 2 mg kg-1, and a canned eel sample with an As concentration that exceeded the limit of Canada's fish standard of 3.5 mg kg-1. This study suggests that the estimated intakes of these seven trace elements from the consumption of foods containing Monascus pose little risk, as the trace element contents in the majority of samples were lower than the permissible/tolerable intakes per week according to the guidelines recommended by the Food and Agricultural Organization/World Health Organization (FAO/WHO). Moreover, their concentrations in foods containing Monascus differ widely for different food varieties, suggesting that external contaminants and raw materials are the main sources of trace elements. This study shows that ICP-MS is a simple method proposed for the determination of As, Cd, Cr, Pb, Se, Cu, and Zn in foods containing Monascus. JF - Food Additives & Contaminants: Part B - Surveillance Communications AU - Tsai, C-F AU - Shih, DY-C AU - Shyu, Y-T AD - Department of Horticulture, National Taiwan University, Taipei, 106, Taiwan, R.O.C,Department of Health, Executive Yuan, Food and Drug Administration, Taipei 115, Taiwan, R.O.C Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 228 EP - 235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 3 IS - 4 SN - 1939-3210, 1939-3210 KW - Risk Abstracts KW - Taiwan KW - dietary supplements KW - Oryza sativa KW - Taiwan, Taipei KW - Lead KW - Trace elements KW - Spectrometry KW - Zinc KW - Monascus KW - raw materials KW - Cadmium KW - Fish KW - Seaweeds KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907180009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+and+risk+assessment+of+trace+elements+in+foods+from+Taiwan+containing+red+mould+rice+%28Monascus%29+by+ICP-MS&rft.au=Tsai%2C+C-F%3BShih%2C+DY-C%3BShyu%2C+Y-T&rft.aulast=Tsai&rft.aufirst=C-F&rft.date=2010-12-01&rft.volume=3&rft.issue=4&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.issn=19393210&rft_id=info:doi/10.1080%2F19393210.2010.513070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - dietary supplements; Zinc; raw materials; Fish; Cadmium; Seaweeds; Lead; Spectrometry; Trace elements; Monascus; Oryza sativa; Taiwan; Taiwan, Taipei DO - http://dx.doi.org/10.1080/19393210.2010.513070 ER - TY - JOUR T1 - Bioaccumulation of cyanuric acid in edible tissues of shrimp following experimental feeding AN - 899137285; 15716319 AB - Due to concerns that cyanuric acid (CYA)-contaminated feed had been used in aquaculture and could enter the human food chain, a method to quantify CYA residues in the edible tissues of fish and shrimp was previously developed and validated. This paper provides further data on the deliberate feeding of CYA to shrimp to determine the extent of residue accumulation in edible tissue. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed for the analysis of CYA in shrimp tissue. Edible tissue of shrimp fed 1666 or 3333 mg kg-1 CYA in their diet (approximately 55 and 124 mg kg-1 body weight) contained 0.767 and 0.406 mg kg-1 CYA, respectively. The residue levels are below the World Health Organization (WHO) tolerable daily intake level for CYA and are generally considered unlikely to pose a human health risk. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Karbiwnyk, Christine M AU - Williams, Rodney R AU - Andersen, Wendy C AU - Turnipseed, Sherri B AU - Madson, Mark R AU - Miller, Keith E AU - Reimschuessel, Renate AD - Animal Drugs Research Center, US Food and Drug Administration, Denver, CO 80225-0087, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1658 EP - 1664 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 27 IS - 12 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Aquaculture KW - Diets KW - Fish KW - Food additives KW - Food chains KW - Residues KW - Tissues KW - body weight KW - feeding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899137285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Bioaccumulation+of+cyanuric+acid+in+edible+tissues+of+shrimp+following+experimental+feeding&rft.au=Karbiwnyk%2C+Christine+M%3BWilliams%2C+Rodney+R%3BAndersen%2C+Wendy+C%3BTurnipseed%2C+Sherri+B%3BMadson%2C+Mark+R%3BMiller%2C+Keith+E%3BReimschuessel%2C+Renate&rft.aulast=Karbiwnyk&rft.aufirst=Christine&rft.date=2010-12-01&rft.volume=27&rft.issue=12&rft.spage=1658&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2010.517221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Diets; Tissues; Food additives; Food chains; Residues; feeding; Fish; body weight; Aquaculture DO - http://dx.doi.org/10.1080/19440049.2010.517221 ER - TY - JOUR T1 - Impacts on type I error rate with inappropriate use of learn and confirm in confirmatory adaptive design trials AN - 888099785; 15039043 AB - A two-stage adaptive design trial is a single trial that combines the learning data from stage 1 (or phase II) and the confirming data in stage 2 (or phase III) for formal statistical testing. We call it a 'Learn and Confirm' trial. The studywise type I error rate remains to be at issue in a 'Learn and Confirm' trial. For studying multiple doses or multiple enpdoints, a 'Learn and Confirm' adaptive design can be more attractive than a fixed design approach. This is because intuitively the learning data in stage 1 should not be subjected to type I error scrutiny if there is no formal interim analysis performed and only an adaptive selection of design parameters is made at stage 1. In this work, we conclude from extensive simulation studies that the intuition is most often misleading. That is, regardless of whether or not there is a formal interim analysis for making an adaptive selection, the type I error rates are always at risk of inflation. Inappropriate use of any 'Learn and Confirm' strategy should not be overlooked. JF - Biometrical Journal AU - Wang, Sue-Jane AU - Hung, H M James AU - O'Neill, Robert T AD - Office of Biostatistics, OTS/CDER, US FDA, 10903 New Hampshire Avenue, HFD-700, Silver Spring, MD 20993-0002, USA, suejane.wang@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 798 EP - 810 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 6 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts KW - Learning KW - Data processing KW - Statistics KW - Biometrics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Injury+Surveillance+for+Youth+on+Farms+in+the+U.S.%2C+2006&rft.au=Hendricks%2C+K+J%3BGoldcamp%2C+E+M&rft.aulast=Hendricks&rft.aufirst=K&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.200900207/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Learning; Statistics; Data processing; Biometrics DO - http://dx.doi.org/10.1002/bimj.200900207 ER - TY - JOUR T1 - Challenges to multiple testing in clinical trials AN - 888099107; 15039039 AB - Multiple testing problems are complex in evaluating statistical evidence in pivotal clinical trials for regulatory applications. However, a common practice is to employ a general and rather simple multiple comparison procedure to handle the problems. Applying multiple comparison adjustments is to ensure proper control of type I error rates. However, in many practices, the emphasis of the type I error rate control often leads to a choice of a statistically valid multiple test procedure but the common sense is overlooked. The challenges begin with confusions in defining a relevant family of hypotheses for which the type I error rates need to be properly controlled. Multiple testing problems are in a wide variety, ranging from testing multiple doses and endpoints jointly, composite endpoint, non-inferiority and superiority, to studying time of onset of a treatment effect, and searching for minimum effective dose or a patient subgroup in which the treatment effect lies. To select a valid and sensible multiple test procedure, the first step should be to tailor the selection to the study questions and to the ultimate clinical decision tree. Then evaluation of statistical power performance should come in to play in the next step to fine tune the selected procedure. JF - Biometrical Journal AU - Hung, H M James AU - Wang, Sue-Jane AD - Division of Biometrics I, OB/OTS/CDER, US FDA, 10903 New Hampshire Ave, HFD-710, Silver Spring, MD 20993-0002, USA, hsienming.hung@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 747 EP - 756 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 52 IS - 6 SN - 1521-4036, 1521-4036 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Play KW - Biometrics KW - Clinical trials KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Challenges+to+multiple+testing+in+clinical+trials&rft.au=Hung%2C+H+M+James%3BWang%2C+Sue-Jane&rft.aulast=Hung&rft.aufirst=H+M&rft.date=2010-12-01&rft.volume=52&rft.issue=6&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=15214036&rft_id=info:doi/10.1002%2Fbimj.200900206 L2 - http://onlinelibrary.wiley.com/doi/10.1002/bimj.200900206/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Play; Statistics; Biometrics; Clinical trials DO - http://dx.doi.org/10.1002/bimj.200900206 ER - TY - JOUR T1 - Antimicrobial Resistance of Campylobacter Isolates from Retail Meat in the United States between 2002 and 2007 AN - 888093057; 14191121 AB - The emergence of antimicrobial resistance in Campylobacter spp. has been a growing public health concern globally. The objectives of this study were to determine the prevalence, antimicrobial susceptibility, and genetic relatedness of Campylobacter spp. recovered by the National Antimicrobial Resistance Monitoring System (NARMS) retail meat program. Retail meat samples (n = 24,566) from 10 U.S. states collected between 2002 and 2007, consisting of 6,138 chicken breast, 6,109 ground turkey, 6,171 ground beef, and 6,148 pork chop samples, were analyzed. A total of 2,258 Campylobacter jejuni, 925 Campylobacter coli, and 7 Campylobacter lari isolates were identified. Chicken breast samples showed the highest contamination rate (49.9%), followed by ground turkey (1.6%), whereas both pork chops and ground beef had <0.5% contamination. The most common resistance was to doxycycline/tetracycline (46.6%), followed by nalidixic acid (18.5%), ciprofloxacin (17.4%), azithromycin and erythromycin (2.8%), telithromycin (2.4%), clindamycin (2.2%), and gentamicin (<0.1%). In a subset of isolates tested, no resistance to meropenem and florfenicol was seen. C. coli isolates showed higher resistance rates to antimicrobials, with the exception of doxycycline/tetracycline, than those seen for C. jejuni. Pulsed-field gel electrophoresis (PFGE) fingerprinting resulted in 1,226 PFGE profiles among the 2,318 isolates, with many clones being widely dispersed throughout the 6-year sampling period. JF - Applied and Environmental Microbiology AU - Zhao, S AU - Young AU - Tong, E AU - Abbott, J W AU - Womack, N AU - Friedman, S L AU - McDermott, P F AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, shaohua.zhao@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 7949 EP - 7956 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 24 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Antimicrobial agents KW - Meat KW - Campylobacter coli KW - A:01330 KW - J:02400 KW - X:24320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888093057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Antimicrobial+Resistance+of+Campylobacter+Isolates+from+Retail+Meat+in+the+United+States+between+2002+and+2007&rft.au=Zhao%2C+S%3BYoung%3BTong%2C+E%3BAbbott%2C+J+W%3BWomack%2C+N%3BFriedman%2C+S+L%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2010-12-01&rft.volume=76&rft.issue=24&rft.spage=7949&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01297-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Meat; Campylobacter coli DO - http://dx.doi.org/10.1128/AEM.01297-10 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF [Beta]-MYRCENE (CAS NO. 123-35-3) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878683497; 21415873 AB - β-Myrcene is the major component of hop and bay oils and lemongrass tea, and is also produced commercially rom β-pinene. It is used widely in cosmetics, soaps and detergents and is a flavoring agent in foods and beverages. We studied the effects of β-myrcene on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing β-myrcene in corn oil directly into the stomach through a tube to groups of 50 male and female rats and mice for two years. Exposed animals received either 0.25, 0.5, or 1.0 gram of β-myrcene per kilogram of body weight. Control animals received corn oil with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. All the male rats receiving 1.0 g/kg β-myrcene and most of the male and female mice receiving 1.0 g/kg β-myrcene died before the end of the study. In the other two groups of male rats receiving β-myrcene the incidences of kidney tumors was markedly increased. Female rats also experienced some kidney tumors, to a lesser extent. Similarly male mice had markedly increased incidences of adenomas and carcinomas of the liver, as did female mice to a lesser extent. We conclude that β-myrcene caused kidney cancers in male rats and liver cancer in male mice, and the occurrence of kidney tumors in female rats and liver tumors in female rats may have been related to β-myrcene administration. In addition β-myrcene was associated with other lesions of the kidney in rats, the liver in mice, and the nose in male rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1 EP - 163 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Monoterpenes KW - beta-myrcene KW - Studies KW - Toxicology KW - Carcinogens KW - Chemicals KW - Rodents KW - Animals KW - Kidney Neoplasms -- pathology KW - Kidney -- pathology KW - Humans KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Mice KW - Neoplasms, Experimental -- pathology KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Liver Neoplasms -- pathology KW - Nose -- pathology KW - Toxicity Tests, Chronic KW - Carcinogenicity Tests KW - Carcinoma, Hepatocellular -- pathology KW - Nose -- drug effects KW - Adenoma -- pathology KW - Male KW - Female KW - Hepatoblastoma -- pathology KW - Monoterpenes -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Kidney Neoplasms -- chemically induced KW - Adenoma -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Hepatoblastoma -- chemically induced KW - Carcinoma, Hepatocellular -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+%5BBeta%5D-MYRCENE+%28CAS+NO.+123-35-3%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Document feature - Tables; Equations; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683486 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683485 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-12-01&rft.volume=&rft.issue=557&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Occupational Distribution of Persons With Confirmed 2009 H1N1 Influenza AN - 874182450; 14292380 AB - Objective: To assess the distribution of illness by industry sector and occupation reflected in early 2009 H1N1 influenza surveillance. Methods: We analyzed data reported for April to July 2009, for 1361 laboratory-confirmed 2009 H1N1 influenza-infected persons 16 years or older, with work status information from four states. A North American Industry Classification System 2007 code was assigned to each employed person. For a subset, an occupation code was assigned. Results: Of 898 employed individuals, 611 (68.0%) worked in the non-health care sector. The largest proportions worked in public administration, educational services, and accommodation and food services. In Wisconsin health care personnel, 53.6% were paraprofessionals, 33.6% professionals, and 12.7% other workers; 26.9% worked in ambulatory settings, 46.2% in hospitals, and 26.9% in nursing or residential care facilities. Conclusions: Our findings suggest that industry sectors and occupations should be explored systematically in future influenza surveillance. JF - Journal of Occupational and Environmental Medicine AU - Suarthana, E AU - Laney, A S AU - Kreiss, K AU - Anderson, HA AU - Hunt, D C AU - Neises, D AU - Goodin, K AU - Thomas, A AU - Vandermeer, M AU - Storey, E AD - National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Room 2806, Morgantown, WV 26505, USA, ESuarthana@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1212 EP - 1216 VL - 52 IS - 12 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Classification KW - Classification systems KW - Data processing KW - Food KW - Health care KW - Hospitals KW - Influenza KW - Medical personnel KW - Nursing KW - Personnel KW - influenza KW - USA, Wisconsin KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874182450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Occupational+Distribution+of+Persons+With+Confirmed+2009+H1N1+Influenza&rft.au=Suarthana%2C+E%3BLaney%2C+A+S%3BKreiss%2C+K%3BAnderson%2C+HA%3BHunt%2C+D+C%3BNeises%2C+D%3BGoodin%2C+K%3BThomas%2C+A%3BVandermeer%2C+M%3BStorey%2C+E&rft.aulast=Suarthana&rft.aufirst=E&rft.date=2010-12-01&rft.volume=52&rft.issue=12&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181fd32e4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Classification systems; Influenza; Data processing; Personnel; Nursing; Food; Medical personnel; Hospitals; Health care; Classification; influenza; USA, Wisconsin DO - http://dx.doi.org/10.1097/JOM.0b013e3181fd32e4 ER - TY - JOUR T1 - Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein AN - 874180273; 14163867 AB - The development of malignant prostate cancer involves multiple genetic alterations. For example, alterations in both survivin and p53 are reported to have crucial roles in prostate cancer progression. However, little is known regarding the interrelationships between p53 and survivin in prostate cancer. Our data demonstrate that the expression of survivin is inversely correlated with that of wtp53 protein (r sub(s)=0.548) in prostate cancer and in normal prostate tissues. We have developed a therapeutic strategy, in which two antitumor factors, small interfering RNA-survivin and p53 protein, are co-expressed from the same plasmid, and have examined their effects on the growth of PC3, an androgen-independent prostate cancer cell line. When p53 was expressed along with a survivin-specific short hairpin RNA (shRNA), tumor cell proliferation was significantly suppressed and apoptosis occurred. In addition, this combination also abrogated the expression of downstream target molecules such as cyclin-dependent kinase 4 and c-Myc, while enhancing the expression of GRIM19. These changes in gene expression occurred distinctly in the presence of survivin-shRNA/wtp53 compared with control or single treatment groups. Intratumoral injection of the co-expressed construct inhibited the growth and survival of tumor xenografts in a nude mouse model. These studies revealed evidence of an interaction between p53 and survivin proteins plus a complex signaling network operating downstream of the wtp53-survivin pathway that actively controls tumor cell proliferation, survival and apoptosis. JF - Cancer Gene Therapy AU - Shao, Y AU - Liu, Y AU - Shao, C AU - Hu, J AU - Li, X AU - Li, F AU - Zhang, L AU - Zhao, D AU - Sun, L AU - Zhao, X AU - Kopecko, D J AU - Kalvakolanu, D V AU - Li, Y AU - Xu, D Q AD - Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 844 EP - 854 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 17 IS - 12 SN - 0929-1903, 0929-1903 KW - Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Cell survival KW - Data processing KW - Apoptosis KW - survivin KW - Gene therapy KW - Animal models KW - Tumors KW - Plasmids KW - Cyclin-dependent kinase 4 KW - Tumor cells KW - p53 protein KW - Tumor cell lines KW - Prostate cancer KW - siRNA KW - Xenografts KW - c-Myc protein KW - Signal transduction KW - W 30905:Medical Applications KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874180273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Enhanced+tumor+suppression+in+vitro+and+in+vivo+by+co-expression+of+survivin-specific+siRNA+and+wild-type+p53+protein&rft.au=Shao%2C+Y%3BLiu%2C+Y%3BShao%2C+C%3BHu%2C+J%3BLi%2C+X%3BLi%2C+F%3BZhang%2C+L%3BZhao%2C+D%3BSun%2C+L%3BZhao%2C+X%3BKopecko%2C+D+J%3BKalvakolanu%2C+D+V%3BLi%2C+Y%3BXu%2C+D+Q&rft.aulast=Shao&rft.aufirst=Y&rft.date=2010-12-01&rft.volume=17&rft.issue=12&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fcgt.2010.41 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Cell survival; Apoptosis; Data processing; Gene therapy; survivin; Animal models; Tumors; Cyclin-dependent kinase 4; Plasmids; Tumor cells; p53 protein; Tumor cell lines; Prostate cancer; siRNA; Xenografts; c-Myc protein; Signal transduction DO - http://dx.doi.org/10.1038/cgt.2010.41 ER - TY - GEN T1 - Data Tables for FACES 2006: Head Start Children Go to Kindergarten Report. ACF-OPRE Report AN - 864941166; ED517212 AB - The Head Start Family and Child Experiences Survey (FACES), sponsored by the U.S. Department of Health and Human Services, Administration for Children and Families (ACF), was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children and their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also includes interviews with the child's parents, teachers, and program managers, as well as direct observations of classroom quality. This set of tables is designed to accompany a research brief that describes the group of children who first entered Head Start in fall 2006 either as a 3- or 4-year-old, completed one or two years in the program, and attended kindergarten the year after graduating from Head Start. Head Start Children Go to Kindergarten profiles the demographic characteristics of this group and describes their home and family life. It includes a description of the schools and kindergarten classrooms Head Start graduates attend. The report documents children's gains in a broad set of skills from program entry to Head Start graduation and to the end of the kindergarten year, and investigates the associations between children's skills when entering and leaving Head Start, their skills at the end of Head Start, and their progress through the spring of their kindergarten year (West et al. 2010b). Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They include information on parents' involvement with their children's elementary schools, the level of satisfaction with their children's schools, and parents' beliefs about how well Head Start prepared their children for kindergarten. In the second set of tables, the authors provide information about the schools Head Start children attend for kindergarten, their kindergarten classrooms, and their teachers. The authors include information on the background of the children in their classrooms as well as educational experiences in the classroom. The third set of tables chronicles children's developmental progress from the time they completed Head Start through the end of kindergarten. In the final two sections, the authors explore (1) the associations between children's school readiness skills as they complete Head Start and their developmental outcomes at the end of kindergarten and (2) the associations of child/family and Head Start characteristics with children's development at the end of Head Start and their developmental progress from Head Start entry to the end of kindergarten. They also explore the relationship of children's relative skills at program entry (that is, low, average, or high ability) to their development progress during this time period. (Contains 109 tables and 18 notes.) [For related report, "Head Start Children Go to Kindergarten. ACF-OPRE Report", see ED517211.] AU - Malone, Lizabeth AU - Hulsey, Lara AU - Aikens, Nikki AU - West, Jerry AU - Tarullo, Louisa Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 198 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Program Effectiveness KW - Socioeconomic Status KW - Teacher Attitudes KW - Correlation KW - Classroom Techniques KW - Credentials KW - Outcomes of Education KW - Preschool Education KW - Educational Experience KW - Disadvantaged Youth KW - School Readiness KW - Measures (Individuals) KW - Family Environment KW - Young Children KW - Longitudinal Studies KW - Risk KW - Profiles KW - Reading Readiness KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941166?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - A Second Year in Head Start: Characteristics and Outcomes of Children Who Entered the Program at Age Three. ACF-OPRE Report AN - 864941055; ED517208 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. This brief profiles the second year in the program for 3-year-old Head Start children and families who were newly enrolled in fall 2006 (see Tarullo et al. 2008) and are still attending in spring 2008. FACES selects two groups of first-time enrollees--those entering at age 4 and those entering at age 3--who are expected to attend Head Start for one or two years, respectively, prior to kindergarten entry. The 3-year-old group is of particular interest for several reasons: (1) as the Head Start Program Information Report (PIR) shows, 3-year-olds occupy a growing share of the total population served by Head Start, increasing from 24 percent in 1980 to 40 percent in 2007 (ACF 2010); (2) they may differ in important characteristics from children who enter at age 4 in terms of developmental level and exposure to prior child care experiences; and (3) they have the potential to continue in Head Start for two program years or to leave for another prekindergarten experience. In the first section of the report, the authors provide background on the study methodology and sample. In the next section, they offer information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They also include information on parent involvement in Head Start and their level of satisfaction with their own and their children's Head Start experiences. Where appropriate, these characteristics are contrasted with those of children who entered as 3-year-olds in fall 2006 but did not complete a second year of Head Start. They chronicle children's developmental progress over two years of Head Start in the final section, considering whether these outcomes vary by gender, race/ethnicity, or risk status. It is important to note that changes in children's skills and development during their program experience reflect a range of influences in their lives, including child-level characteristics, such as maturation and health status, as well as community, program, classroom, peer, and family influences. (Contains 14 figures, 1 table and 33 notes.) [For related report, "Data Tables for FACES 2006: A Second Year in Head Start Report. ACF-OPRE Report," see ED517210.] AU - Tarullo, Louisa AU - Aikens, Nikki AU - Moiduddin, Emily AU - West, Jerry Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 32 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Demography KW - Educational Experience KW - Kindergarten KW - Health Conditions KW - Child Development KW - Program Evaluation KW - Preschool Evaluation KW - Gender Differences KW - Educational Indicators KW - Racial Differences KW - Educational Environment KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Educational Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941055?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Head Start Children Go to Kindergarten. ACF-OPRE Report AN - 864941037; ED517211 AB - The Head Start Family and Child Experiences Survey (FACES), sponsored by the U.S. Department of Health and Human Services, Administration for Children and Families (ACF), was first launched in 1997 as a periodic longitudinal study of program performance. This report is the fourth in a series that uses data from the FACES 2006 cohort to describe the population of 3- and 4-year-olds who entered Head Start for the first time in fall 2006, their families, and their classrooms. Guided by the FACES conceptual framework (Figure 1), earlier reports documented the diversity in the Head Start population in terms of demographic and socioeconomic characteristics, the skills that children have when they first enter the program, and the gains in these skills over one or two years of program participation. The current report describes the group of children who first entered Head Start in fall 2006 either as a 3- or 4-year-old, completed one or two years in the program, and attended kindergarten the year after graduating from Head Start. As in the earlier reports, the authors profile the demographic characteristics of this group and describe their home and family life, drawing comparisons where appropriate to the characteristics of the population of children and families when they first entered Head Start or after completing one year in the program. New to this report is a description of the schools and kindergarten classrooms Head Start graduates attend. The authors describe broad characteristics of their schools such as size, student body composition, and school type. They describe children's kindergarten classrooms and teachers, including information on characteristics such as the length of the school day (full- versus half-day kindergarten), class size, child-to-staff ratio, and teachers' experience and degrees. They once again document children's gains in a broad set of skills from program entry to Head Start graduation and to the end of the kindergarten year, and investigate the associations between children's skills when entering and leaving Head Start, their skills at the end of Head Start, and their progress through the spring of their kindergarten year. The findings in the report are intended to answer five research questions: (1) What are the child/family demographics and home environment characteristics of children who complete Head Start and enroll in kindergarten? How involved are their parents in their schools and education?; (2) What are the characteristics of the schools and kindergarten programs children attend after completing Head Start? What are the characteristics of their kindergarten classrooms and teachers?; (3) What developmental gains do children make during Head Start and beyond? How do their skills compare to those of their peers; (4) Are children's school readiness skills at the end of Head Start related to developmental outcomes at the end of kindergarten? Are there cross-domain relationships between children's language, literacy, math, and social-emotional skills?; and (5) What child/family and Head Start characteristics relate to children's development at the end of Head Start and the gains they make from the time they enter Head Start through the spring of kindergarten? Does their growth in school readiness skills vary by their skills when first entering Head Start? The remainder of the report is organized into six sections. First, the authors provide background on the study methodology and sample. Second, they offer information on children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. They include information on parents' involvement with their children's elementary schools, the level of satisfaction with their children's schools, and parents' beliefs about how well Head Start prepared their children for kindergarten. Third, they describe the schools Head Start children attend for kindergarten, their kindergarten classrooms, and their teachers. They include information on the background of the children in their classrooms as well as educational experiences in the classroom. Fourth, they chronicle children's developmental progress from the time they completed Head Start through the end of kindergarten, considering whether these outcomes vary by gender, race/ethnicity, or risk status. Fifth, they explore the associations between children's school readiness skills as they complete Head Start and their developmental outcomes at the end of kindergarten. Sixth, they investigate associations of child/family and Head Start characteristics with children's development at the end of Head Start and their developmental progress from Head Start entry to the end of kindergarten. They also explore the relationship of children's relative skills at program entry (that is, low, average, or high ability) to their development progress during this time period. (Contains 2 tables, 26 figures and 70 endnotes.) [For related report, "The Data Tables for FACES 2006: Head Start Children Go to Kindergarten. ACF-OPRE Report", see ED517212.] AU - West, Jerry AU - Malone, Lizabeth AU - Hulsey, Lara AU - Aikens, Nikki AU - Tarullo, Louisa Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 62 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - Peabody Picture Vocabulary Test (Revised) KW - Woodcock Johnson Tests of Achievement KW - Early Childhood Longitudinal Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Student Characteristics KW - Recess Breaks KW - Body Composition KW - Child Care KW - Correlation KW - Whites KW - Minority Groups KW - Hispanic Americans KW - Teaching Experience KW - Parent School Relationship KW - Developmental Stages KW - Child Development KW - Disadvantaged Youth KW - Low Income Groups KW - Family Environment KW - Gender Differences KW - Language Skills KW - Mental Health KW - Racial Differences KW - Teacher Student Ratio KW - Parent Participation KW - Parent Attitudes KW - Program Effectiveness KW - Parent Influence KW - Socioeconomic Status KW - School Schedules KW - Child Health KW - Social Support Groups KW - Student Diversity KW - Discipline KW - Nutrition KW - Mathematics Skills KW - Skill Development KW - Teacher Certification KW - Spanish Speaking KW - Social Development KW - Language of Instruction KW - School Readiness KW - Class Size KW - Institutional Characteristics KW - Cognitive Development KW - Young Children KW - Leisure Time KW - Reading Skills KW - Longitudinal Studies KW - English (Second Language) KW - Emotional Development KW - Interpersonal Competence KW - Early Intervention KW - School Size KW - Physical Activity Level UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941037?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Data Tables for FACES 2006: A Second Year in Head Start Report. ACF-OPRE Report AN - 864939754; ED517210 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs, and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers, and program managers, as well as direct observations of classroom quality. FACES is a tool for measuring Head Start program performance at the national level. This recurring data collection provides the means to assess program performance both currently and over time. This set of tables is designed to accompany a research brief which profiles the second year in the program for 3-year-old Head Start children and families who were newly enrolled in fall 2006 (ACF 2010b) and are still attending in spring 2008. FACES selects two groups of first-time enrollees--those entering at age 4 and those entering at age 3--who are expected to attend Head Start for one or two years, respectively, prior to kindergarten entry. The 3-year-old group is of particular interest for several reasons: (1) as the Head Start Program Information Report (PIR) shows, 3-year-olds occupy a growing share of the total population served by Head Start, increasing from 24 percent in 1980 to 40 percent in 2007 (ACF 2010a); (2) they may differ in important characteristics from children who enter at age 4 in terms of developmental level and exposure to prior care experiences; and (3) they have the potential to continue in Head Start for two program years or to leave for another prekindergarten experience. Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. The authors also include information on parent involvement in Head Start and their level of satisfaction with their own and their children's Head Start experiences. In the next set of tables, the authors provide information on children's developmental progress over two years of Head Start, including whether these outcomes vary by gender, race/ethnicity, or risk status. It is important to note that changes in children's skills and development during their program experience reflect a range of influences in their lives, including child-level characteristics, such as maturation and health status, as well as community, program, classroom, peer, and family influences. (Contains 55 tables and 15 notes.) [For related report, "A Second Year in Head Start: Characteristics and Outcomes of Children Who Entered the Program at Age Three. ACF-OPRE Report", see ED517208.] AU - Moiduddin, Emily AU - Aikens, Nikki AU - Tarullo, Louisa AU - West, Jerry Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 79 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Kindergarten KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Achievement Rating KW - Student Characteristics KW - Academic Achievement KW - Family Life KW - Student Records KW - Participant Satisfaction KW - Demography KW - Parent School Relationship KW - Child Development KW - Statistical Data KW - Preschool Evaluation KW - Family Environment KW - Annual Reports KW - School Statistics KW - Achievement Gains KW - Educational Environment KW - Individual Differences KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864939754?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - What does 'occupation' represent as an indicator of socioeconomic status?: Exploring occupational prestige and health AN - 853216924; 201100837 AB - The association between socioeconomic status (SES) and health has been widely documented. However, the role of occupation in this association is not clear because occupation is less often used than income and education as an indicator of SES, especially in the United States. This may be caused by the ambiguity in what occupation represents: both health-enhancing resources (e.g., self-affirmation) and health-damaging hazards (e.g., job stress). SES has two aspects: resources and status. While income and education represent resources and imply status, occupational prestige is an explicit indicator of the social status afforded by one's occupation. Using data from the US General Social Survey in 2002 and 2006 (n=3151), we examine whether occupational prestige has a significant association with self-rated health independent from other SES indicators (income, education), occupational categories (e.g., managerial, professional, technical, service), and previously established work-related health determinants (job strain, work place social support, job satisfaction). After all covariates were included in the multiple logistic regression model, higher occupational prestige was associated with lower odds of reporting poor/fair self-rated health. We discuss potential mechanisms through which occupational prestige may impact health. Our findings not only suggest multiple ways that occupation is associated with health, but also highlight the utility of occupational prestige as an SES indicator that explicitly represents social standing. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Fujishiro, Kaori AU - Xu, Jun AU - Gong, Fang AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway (R-15), Cincinnati, Ohio 45226, United States kfujishiro@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 2100 EP - 2107 PB - Elsevier Science, Amsterdam The Netherlands VL - 71 IS - 12 SN - 0277-9536, 0277-9536 KW - USA Socioeconomic status Self-rated health Job strain Job satisfaction Social standing KW - Prestige KW - Socioeconomic Status KW - Health Problems KW - Health KW - Health Care Services KW - Income KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853216924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=What+does+%27occupation%27+represent+as+an+indicator+of+socioeconomic+status%3F%3A+Exploring+occupational+prestige+and+health&rft.au=Fujishiro%2C+Kaori%3BXu%2C+Jun%3BGong%2C+Fang&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2010-12-01&rft.volume=71&rft.issue=12&rft.spage=2100&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2010.09.026 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-02-16 N1 - Number of references - 27 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Socioeconomic Status; Prestige; Health; Income; Health Care Services; Health Problems DO - http://dx.doi.org/10.1016/j.socscimed.2010.09.026 ER - TY - JOUR T1 - Perception of facial emotion in adults with bipolar or unipolar depression and controls AN - 853208996; 201106214 AB - Previous research indicates that patients with depression display deficits in their ability to perceive emotions. However, few studies have used animated facial stimuli or explored sensitivity to facial expressions in depressed individuals. Moreover, limited research is available on facial processing in unipolar versus bipolar depression. In this study, 34 patients with DSM-IV major depressive disorder (MDD), 21 patients with DSM-IV bipolar disorder (BPD) in the depressed phase, and 24 never-depressed controls completed the Emotional Expression Multimorph Task, which presents facial emotions in gradations from neutral to 100% emotional expression (happy, sad, surprised, fearful, angry, and disgusted). Groups were compared in terms of sensitivity and accuracy in identifying emotions. Our preliminary findings suggest that subjects with bipolar depression may have emotional processing abnormalities relative to controls. [Copyright Elsevier Ltd.] JF - Journal of Psychiatric Research AU - Schaefer, Kathryn L AU - Baumann, Jacqueline AU - Rich, Brendan A AU - Luckenbaugh, David A AU - Zarate, Carlos A, Jr AD - Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1229 EP - 1235 PB - Elsevier Ltd, Oxford UK VL - 44 IS - 16 SN - 0022-3956, 0022-3956 KW - Bipolar disorder (BPD) Cognition Facial expression Emotion perception Unipolar depression KW - Depressive personality disorders KW - Sensitivity KW - Emotions KW - Visual processing KW - Facial expressions KW - Bipolar affective disorder KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853208996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychiatric+Research&rft.atitle=Perception+of+facial+emotion+in+adults+with+bipolar+or+unipolar+depression+and+controls&rft.au=Schaefer%2C+Kathryn+L%3BBaumann%2C+Jacqueline%3BRich%2C+Brendan+A%3BLuckenbaugh%2C+David+A%3BZarate%2C+Carlos+A%2C+Jr&rft.aulast=Schaefer&rft.aufirst=Kathryn&rft.date=2010-12-01&rft.volume=44&rft.issue=16&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychiatric+Research&rft.issn=00223956&rft_id=info:doi/10.1016%2Fj.jpsychires.2010.04.024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - CODEN - JPYRA3 N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Emotions; Facial expressions; Sensitivity; Depressive personality disorders; Visual processing DO - http://dx.doi.org/10.1016/j.jpsychires.2010.04.024 ER - TY - JOUR T1 - Buprenorphine: A Guide for Nurses (Technical Assistance Publication) AN - 853207790; 201104882 AB - Nurses working in opioid treatment programs (OTPs) and office-based community settings have essential roles in the assessment, screening, treatment monitoring and counseling of patients receiving buprenorphine for the treatment of opioid addiction. However, challenges to implementing buprenorphine treatment with patients addicted to opioids or other drugs, including medication diversion and confidentiality issues, require nurses to improve their professional skills and prepare themselves for the implementation of best practices in addiction settings. Recent studies have found that inconsistency between science and practice is often attributed to inadequate staff education and training. Nurses working in addiction settings have reported, on an ongoing basis, attending very few clinical trainings in the area of substance abuse. This guide highlights the addiction management skills of nurses and promotes a mutually respectful team environment in which nurses and physicians collaboratively work to improve the care provided to opioid addicted individuals, including assessment, induction, stabilization, maintenance, monitoring, addiction counseling and relapse prevention services. It also serves as a resource to help nurses working with community/office based physicians to improve treatment outcomes for individuals receiving office-based treatment for opioid addiction. Adapted from the source document. JF - Journal of Addictions Nursing AU - Azimi-Bolourian, Sara AU - Fornili, Katherine AD - SAMHSA, CSAT/DPT, 1 Choke Cherry Road, Rockville, MD, 20853 sara.azimi-bolourian@samhsa.hhs.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 183 EP - 186 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 21 IS - 4 SN - 1088-4602, 1088-4602 KW - Addiction Awareness/ Prevention/ Screening/ Education Co-occurring Disorders Substance Abuse Substance Use Disorder KW - Buprenorphine KW - Doctors KW - Counselling KW - Nurses KW - Opioids KW - Addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853207790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictions+Nursing&rft.atitle=Buprenorphine%3A+A+Guide+for+Nurses+%28Technical+Assistance+Publication%29&rft.au=Azimi-Bolourian%2C+Sara%3BFornili%2C+Katherine&rft.aulast=Azimi-Bolourian&rft.aufirst=Sara&rft.date=2010-12-01&rft.volume=21&rft.issue=4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictions+Nursing&rft.issn=10884602&rft_id=info:doi/10.3109%2F10884601003628146 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-02-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Addiction; Opioids; Buprenorphine; Doctors; Counselling DO - http://dx.doi.org/10.3109/10884601003628146 ER - TY - JOUR T1 - CHECKING THE FOUNDATION: RECENT RADIOBIOLOGY AND THE LINEAR NO-THRESHOLD THEORY AN - 839707225; 14092160 AB - The linear no-threshold (LNT) theory has been adopted as the foundation of radiation protection standards and risk estimation for several decades. The "microdosimetric argument" has been offered in support of the LNT theory. This argument postulates that energy is deposited in critical cellular targets by radiation in a linear fashion across all doses down to zero, and that this in turn implies a linear relationship between dose and biological effect across all doses. This paper examines whether the microdosimetric argument holds at the lowest levels of biological organization following low dose, low dose-rate exposures to ionizing radiation. The assumptions of the microdosimetric argument are evaluated in light of recent radiobiological studies on radiation damage in biological molecules and cellular and tissue level responses to radiation damage. There is strong evidence that radiation initially deposits energy in biological molecules (e.g., DNA) in a linear fashion, and that this energy deposition results in various forms of prompt DNA damage that may be produced in a pattern that is distinct from endogenous (e.g., oxidative) damage. However, a large and rapidly growing body of radiobiological evidence indicates that cell and tissue level responses to this damage, particularly at low doses and/or dose-rates, are nonlinear and may exhibit thresholds. To the extent that responses observed at lower levels of biological organization in vitro are predictive of carcinogenesis observed in vivo, this evidence directly contradicts the assumptions upon which the microdosimetric argument is based. JF - Health Physics AU - Ulsh, BA AD - National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mailstop C-46, Cincinnati, OH 45226, USA, bau6@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 747 EP - 758 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 6 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - biological effects KW - Ionizing radiation KW - Carcinogenesis KW - DNA KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839707225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=CHECKING+THE+FOUNDATION%3A+RECENT+RADIOBIOLOGY+AND+THE+LINEAR+NO-THRESHOLD+THEORY&rft.au=Ulsh%2C+BA&rft.aulast=Ulsh&rft.aufirst=BA&rft.date=2010-12-01&rft.volume=99&rft.issue=6&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181e32477 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - biological effects; Ionizing radiation; Carcinogenesis; DNA DO - http://dx.doi.org/10.1097/HP.0b013e3181e32477 ER - TY - JOUR T1 - Payment Reform AN - 839570354; 201101342 AB - A discussion of Medicare and Medicaid payment reform. Adapted from the source document. JF - Health Services Research AU - Fraser, Irene AU - Encinosa, William AU - Baker, Laurence AD - Center for Delivery, Organization, and Markets, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1847 EP - 1853 PB - Blackwell Publishers, Oxford UK VL - 45 IS - 6p2 SN - 0017-9124, 0017-9124 KW - Medicare KW - Medicaid KW - Payments KW - Reforms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Payment+Reform&rft.au=Fraser%2C+Irene%3BEncinosa%2C+William%3BBaker%2C+Laurence&rft.aulast=Fraser&rft.aufirst=Irene&rft.date=2010-12-01&rft.volume=45&rft.issue=6p2&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2010.01208.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Reforms; Payments; Medicaid; Medicare DO - http://dx.doi.org/10.1111/j.1475-6773.2010.01208.x ER - TY - JOUR T1 - Melamine toxicity--stones vs. crystals. AN - 815965970; 20721654 JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Reimschuessel, Renate AU - Puschner, Birgit AD - Center For Veterinary Medicine, FDA, Office of Research, 8401 Muirkirk Road, 20708, Laurel, MD, USA. renate.reimschuessel@fda.hhs.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 468 EP - 9; discussion 470 VL - 6 IS - 4 KW - Triazines KW - 0 KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Infant KW - Animals, Domestic KW - Animals KW - Infant Formula KW - Animal Feed KW - Humans KW - Infant, Newborn KW - Food Contamination KW - Animals, Laboratory KW - China KW - Crystallization KW - Kidney Calculi -- chemically induced KW - Kidney Calculi -- veterinary KW - Triazines -- poisoning KW - Triazines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815965970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Difference+in+expression+of+hepatic+microRNAs+miR-29c%2C+miR-34a%2C+miR-155%2C+and+miR-200b+is+associated+with+strain-specific+susceptibility+to+dietary+nonalcoholic+steatohepatitis+in+mice.&rft.au=Pogribny%2C+Igor+P%3BStarlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BRoss%2C+Sharon+A%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-01&rft.volume=90&rft.issue=10&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2010.113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-12 N1 - Date created - 2010-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Med Toxicol. 2010 Mar;6(1):50-5 [20195812] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s13181-010-0107-5 ER - TY - JOUR T1 - Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. AN - 815962884; 20798247 AB - Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important health concern of welding fume (WF) exposure is neurological dysfunction akin to Parkinson's disease (PD), thought to be mediated by manganese (Mn) in the fumes. Also, there is a proposition that welding might accelerate the onset of PD. Our recent findings link the presence of Mn in the WF with dopaminergic neurotoxicity seen in rats exposed to manual metal arc-hard surfacing (MMA-HS) or gas metal arc-mild steel (GMA-MS) fumes. To elucidate the molecular mechanisms further, we investigated the association of PD-linked (Park) genes and mitochondrial function in causing dopaminergic abnormality. Repeated instillations of the two fumes at doses that mimic ∼1 to 5 yr of worker exposure resulted in selective brain accumulation of Mn. This accumulation caused impairment of mitochondrial function and loss of tyrosine hydroxylase (TH) protein, indicative of dopaminergic injury. A fascinating finding was the altered expression of Parkin (Park2), Uchl1 (Park5), and Dj1 (Park7) proteins in dopaminergic brain areas. A similar regimen of manganese chloride (MnCl(2)) also caused extensive loss of striatal TH, mitochondrial electron transport components, and Park proteins. As mutations in PARK genes have been linked to early-onset PD in humans, and because welding is implicated as a risk factor for parkinsonism, PARK genes might play a critical role in WF-mediated dopaminergic dysfunction. Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Wirth, Oliver AU - Hayashi, Yusuke AU - Krajnak, Kristine M AU - Soukup, Joleen M AU - Ghio, Andrew J AU - Reynolds, Steven H AU - Castranova, Vincent AU - Munson, Albert E AU - Antonini, James M AD - Toxicology and Molecular Biology Branch, Mailstop L-3014, CDC-NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 4989 EP - 5002 VL - 24 IS - 12 KW - Air Pollutants, Occupational KW - 0 KW - Chlorides KW - Manganese Compounds KW - Manganese KW - 42Z2K6ZL8P KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Ubiquitin-Protein Ligases KW - EC 2.3.2.27 KW - parkin protein KW - UCHL1 protein, rat KW - EC 3.4.19.12 KW - Ubiquitin Thiolesterase KW - manganese chloride KW - QQE170PANO KW - Index Medicus KW - Chlorides -- toxicity KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Air Pollutants, Occupational -- toxicity KW - Rats KW - Polymerase Chain Reaction KW - Blotting, Western KW - Rats, Sprague-Dawley KW - Ubiquitin Thiolesterase -- metabolism KW - Ubiquitin Thiolesterase -- genetics KW - Tyrosine 3-Monooxygenase -- genetics KW - Ubiquitin-Protein Ligases -- genetics KW - Occupational Exposure -- adverse effects KW - Ubiquitin-Protein Ligases -- metabolism KW - Male KW - Inhalation Exposure -- adverse effects KW - Parkinson Disease -- etiology KW - Manganese -- metabolism KW - Parkinson Disease -- metabolism KW - Welding KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815962884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Mitochondrial+dysfunction+and+loss+of+Parkinson%27s+disease-linked+proteins+contribute+to+neurotoxicity+of+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BWirth%2C+Oliver%3BHayashi%2C+Yusuke%3BKrajnak%2C+Kristine+M%3BSoukup%2C+Joleen+M%3BGhio%2C+Andrew+J%3BReynolds%2C+Steven+H%3BCastranova%2C+Vincent%3BMunson%2C+Albert+E%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2010-12-01&rft.volume=24&rft.issue=12&rft.spage=4989&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.10-163964 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-04 N1 - Date created - 2010-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1096/fj.10-163964 ER - TY - JOUR T1 - In vivo mutation analysis using the ΦX174 transgenic mouse and comparisons with other transgenes and endogenous genes. AN - 812136073; 20637298 AB - The ΦX174 transgenic mouse was first developed as an in vivo Ames test, detecting base pair substitution (bps) at a single bp in a reversion assay. A forward mutational assay was also developed, which is a gain of function assay that also detects bps exclusively. Later work with both assays focused on establishing that a mutation was fixed in vivo using single-burst analysis: determining the number of mutant progeny virus from an electroporated cell by dividing the culture into aliquots before scoring mutants. We review results obtained from single-burst analysis, including testing the hypothesis that high mutant frequencies (MFs) of G:C to A:T mutation recovered by transgenic targets include significant numbers of unrepaired G:T mismatches. Comparison between the ΦX174 and lacI transgenes in mouse spleen indicates that the spontaneous bps mutation frequency per nucleotide (mf(n)) is not significantly lower for ΦX174 than for lacI; the response to ENU is also comparable. For the lacI transgene, the spontaneous bps mf(n) is highly age-dependent up to 12 weeks of age and the linear trend extrapolates at conception to a frequency close to the human bps mf(n) per generation of 1.7 × 10(-8). Unexpectedly, we found that the lacI somatic (spleen) bps mf(n) per cell division at early ages was estimated to be the same as for the human germ-line. The bps mf(n) in bone marrow for the gpt transgene is comparable to spleen for the lacI and ΦX174 transgenes. We conclude that the G:C to A:T transition is characteristic of spontaneous in vivo mutation and that the MFs measured in these transgenes at early ages reflect the expected accumulation of in vivo mutation typical of endogenous mammalian mutation rates. However, spontaneous and induced mf(n)s per nucleotide for the cII gene in spleen are 5-10 times higher than for these other transgenes. Published by Elsevier B.V. JF - Mutation research AU - Valentine, Carrie R AU - Delongchamp, Robert R AU - Pearce, Mason G AU - Rainey, Heather F AU - Dobrovolsky, Vasily N AU - Malling, Heinrich V AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, 3900 NCTR Road, HFT-120, Jefferson, AR 72079, USA. Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 205 EP - 216 VL - 705 IS - 3 SN - 0027-5107, 0027-5107 KW - Lac Repressors KW - 0 KW - Index Medicus KW - Animals KW - Spleen -- metabolism KW - Genetic Techniques KW - Models, Genetic KW - Humans KW - Mice KW - Lac Repressors -- genetics KW - Time Factors KW - Mutation KW - Germ Cells -- cytology KW - DNA Mutational Analysis KW - Transgenes KW - Bacteriophage phi X 174 -- genetics KW - Mice, Transgenic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/812136073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=In+vivo+mutation+analysis+using+the+%CE%A6X174+transgenic+mouse+and+comparisons+with+other+transgenes+and+endogenous+genes.&rft.au=Valentine%2C+Carrie+R%3BDelongchamp%2C+Robert+R%3BPearce%2C+Mason+G%3BRainey%2C+Heather+F%3BDobrovolsky%2C+Vasily+N%3BMalling%2C+Heinrich+V%3BHeflich%2C+Robert+H&rft.aulast=Valentine&rft.aufirst=Carrie&rft.date=2010-12-01&rft.volume=705&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrrev.2010.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-03 N1 - Date created - 2010-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.mrrev.2010.07.001 ER - TY - JOUR T1 - Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. AN - 760237405; 20804780 AB - The primary objective of this study was to determine and characterize surrogate biomarkers that can predict nephrotoxicity induced by mercuric chloride (HgCl₂) using urinary proton nuclear magnetic resonance (¹H NMR) spectral data. A procedure for (1)H NMR urinalysis using pattern recognition was proposed to evaluate nephrotoxicity induced by HgCl₂ in Sprague-Dawley rats. HgCl₂ at 0.1 or 0.75 mg/kg was administered intraperitoneally (i.p.), and urine was collected every 24 h for 6 days. Animals (n=6 per group) were sacrificed 3 or 6 days post-dosing in order to perform clinical blood chemistry tests and histopathologic examinations. Urinary ¹H NMR spectroscopy revealed apparent differential clustering between the control and HgCl₂ treatment groups as evidenced by principal component analysis (PCA) and partial least square (PLS)-discriminant analysis (DA). Time- and dose-dependent separation of HgCl₂-treated animals from controls was observed by PCA of ¹H NMR spectral data. In HgCl₂-treated rats, the concentrations of endogenous urinary metabolites of glucose, acetate, alanine, lactate, succinate, and ethanol were significantly increased, whereas the concentrations of 2-oxoglutarate, allantoin, citrate, formate, taurine, and hippurate were significantly decreased. These endogenous metabolites were selected as putative biomarkers for HgCl₂-induced nephrotoxicity. A dose response was observed in concentrations of lactate, acetate, succinate, and ethanol, where severe disruption of the concentrations of 2-oxoglutarate, citrate, formate, glucose, and taurine was observed at the higher dose (0.75 mg/kg) of HgCl₂. Correlation of urinary (1)H NMR PLS-DA data with renal histopathologic changes suggests that ¹H NMR urinalysis can be used to predict or screen for HgCl₂-induced nephrotoxicity. Copyright © 2010 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Kim, Kyu-Bong AU - Um, So Young AU - Chung, Myeon Woo AU - Jung, Seung Chul AU - Oh, Ji Seon AU - Kim, Seon Hwa AU - Na, Han Sung AU - Lee, Byung Mu AU - Choi, Ki Hwan AD - Korea Food and Drug Administration, 5-Nokbun-dong, Eunpyung-gu, Seoul 122-704, Republic of Korea. kyubong@inje.ac.kr Y1 - 2010/12/01/ PY - 2010 DA - 2010 Dec 01 SP - 114 EP - 126 VL - 249 IS - 2 KW - Biomarkers KW - 0 KW - Mercuric Chloride KW - 53GH7MZT1R KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Biomarkers -- urine KW - Time Factors KW - Metabolomics KW - Male KW - Magnetic Resonance Spectroscopy KW - Mercuric Chloride -- urine KW - Mercuric Chloride -- blood KW - Acute Kidney Injury -- chemically induced KW - Mercuric Chloride -- toxicity KW - Acute Kidney Injury -- blood KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760237405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Toxicometabolomics+approach+to+urinary+biomarkers+for+mercuric+chloride+%28HgCl%E2%82%82%29-induced+nephrotoxicity+using+proton+nuclear+magnetic+resonance+%28%C2%B9H+NMR%29+in+rats.&rft.au=Kim%2C+Kyu-Bong%3BUm%2C+So+Young%3BChung%2C+Myeon+Woo%3BJung%2C+Seung+Chul%3BOh%2C+Ji+Seon%3BKim%2C+Seon+Hwa%3BNa%2C+Han+Sung%3BLee%2C+Byung+Mu%3BChoi%2C+Ki+Hwan&rft.aulast=Kim&rft.aufirst=Kyu-Bong&rft.date=2010-12-01&rft.volume=249&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2010.08.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-24 N1 - Date created - 2010-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2010.08.017 ER - TY - JOUR T1 - The potential impact of light emitting diode lighting on reducing mining injuries during operation and maintenance of lighting systems AN - 760216739; 13667980 AB - Research by the US National Institute for Occupational Safety and Health (NIOSH) indicates that light emitting diodes (LEDs) can be used to enhance safety by improving a miner's ability to see mining hazards and reducing glare. This paper investigates if LEDs provide another benefit by reducing miner exposure to hazards during maintenance and operation of LED lighting. LEDs could provide useful lives up to 50 times longer than incandescent lighting commonly used in mining and could enable design changes to reduce certain hazards. The mining accident records compiled by the Mine Safety and Health Administration (MSHA) were examined to determine the extent and nature of accidents involving the maintenance and operation of mine luminaries. A total of 140 relevant accident records were found for the years 2002-2006. These incidents resulted in 3668days lost from work with an additional 925days of restricted activity. The injury narratives were studied to determine if the implementation of LED-based luminaries could reduce injury severity and frequency. The greatest near-term potential impacts appear to be related to reducing maintenance and cap lamp redesign. Longer term (5years), low-power and lightweight auxiliary LED lighting for surface mines could also have potential impact for improving safety. JF - Safety Science AU - Yenchek, Michael R AU - Sammarco, John J AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, P.O. Box 18070, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA, mby5@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1380 EP - 1386 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 48 IS - 10 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Illumination KW - Light emitting diode KW - Safety KW - Mining KW - Accidents KW - safety engineering KW - Safety regulations KW - Injuries KW - Occupational safety KW - Lighting KW - Mines KW - Maintenance KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760216739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=The+potential+impact+of+light+emitting+diode+lighting+on+reducing+mining+injuries+during+operation+and+maintenance+of+lighting+systems&rft.au=Yenchek%2C+Michael+R%3BSammarco%2C+John+J&rft.aulast=Yenchek&rft.aufirst=Michael&rft.date=2010-12-01&rft.volume=48&rft.issue=10&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2010.05.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Accidents; Safety regulations; safety engineering; Injuries; Occupational safety; Lighting; Mining; Mines; Maintenance DO - http://dx.doi.org/10.1016/j.ssci.2010.05.011 ER - TY - JOUR T1 - Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects. AN - 757177194; 20925447 AB - The development of novel engineered nano-sized materials is a rapidly emerging technology with many applications in medicine and industry. In vitro and in vivo studies have suggested many deleterious effects of carbon nanotube exposure including granulomatous inflammation, release of cytosolic enzymes, pulmonary fibrosis, reactive oxygen damage, cellular atypia, DNA fragmentation, mutation and errors in chromosome number as well as mitotic spindle disruption. The physical properties of the carbon nanotubes make respiratory exposure to workers likely during the production or use of commercial products. Many of the investigations of the genotoxicity of carbon nanotubes have focused on reactive oxygen mediated DNA damage; however, the long thin tubular-shaped carbon nanotubes have a striking similarity to cellular microtubules. The similarity of carbon nanotubes to microtubules suggests a potential to interact with cellular biomolecules, such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. Disruption of centrosomes and mitotic spindles would result in monopolar, tripolar, and quadrapolar divisions of chromosomes. The resulting aneuploidy is a key mechanism in the potential carcinogenicity of carbon nanotubes. JF - Nanotoxicology AU - Sargent, Linda M AU - Reynolds, Steven H AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia 26505, USA. LSargent@cdc.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 396 EP - 408 VL - 4 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Animals KW - Mutagenicity Tests -- methods KW - Particle Size KW - Humans KW - Cell Line, Tumor KW - Nanotubes, Carbon -- chemistry KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757177194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Potential+pulmonary+effects+of+engineered+carbon+nanotubes%3A+in+vitro+genotoxic+effects.&rft.au=Sargent%2C+Linda+M%3BReynolds%2C+Steven+H%3BCastranova%2C+Vincent&rft.aulast=Sargent&rft.aufirst=Linda&rft.date=2010-12-01&rft.volume=4&rft.issue=&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2010.500444 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-19 N1 - Date created - 2010-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/17435390.2010.500444 ER - TY - JOUR T1 - Brominated and Chlorinated Flame Retardants: The San Antonio Statement AN - 1677922325; 14160346 AB - Abstract not available. JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Bergman, Aake AD - Director, NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina birnbaumls@niehs.nih.gov Y1 - 2010/12// PY - 2010 DA - December 2010 SP - A514 EP - A515 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Flame retardants KW - Bromination KW - Health KW - Chlorination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677922325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Brominated+and+Chlorinated+Flame+Retardants%3A+The+San+Antonio+Statement&rft.au=Birnbaum%2C+Linda+S%3BBergman%2C+Aake&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-12-01&rft.volume=118&rft.issue=2&rft.spage=A514&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1003088 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-10-04 DO - http://dx.doi.org/10.1289/ehp.1003088 ER - TY - GEN T1 - The Head Start Child Development and Early Learning Framework: Promoting Positive Outcomes in Early Childhood Programs Serving Children 3-5 Years Old AN - 1651854718; ED547179 AB - This report presents a revision of the Head Start Child Outcomes Framework (2000), renamed The Head Start Child Development and Learning Framework: Promoting Positive Outcomes in Early Childhood Programs Serving Children 3-5 Years Old. The Framework outlines the essential areas of development and learning that are to be used by Head Start programs to establish school readiness goals for their children, monitor children's progress, align curricula, and conduct program planning. It can be used to guide curriculum, implementation, and assessment to plan teaching and learning experiences that align to school readiness goals and track children's progress across developmental domains. The Framework is organized into 11 Domains, 37 Domain Elements, and over 100 Examples. The domains and domain elements are organized in a similar way to the original Framework to facilitate a transition to the revised one. The changes to the revised Framework are designed to provide more clarity to the domains and domain elements of the original Framework and do not create new requirements for Head Start grantees. The early childhood field has changed dramatically. The population of children served by Head Start and other early childhood programs continues to grow more diverse. New research has improved the Office of Head Start's understanding of school readiness, and the Improving Head Start for School Readiness Act of 2007 has increased the Framework's role in Head Start programs. In addition, almost every state now has early learning standards. Also, new reporting systems have emerged at the state level and through the Office of Special Education Programs (OSEP) within the U.S. Department of Education. The Framework is revised in light of these realities. [This report was prepared by the Head Start Resource Center.] Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 28 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Thinking Skills KW - Language Acquisition KW - Child Health KW - Student Diversity KW - Health Education KW - Mathematics Skills KW - Bilingualism KW - Preschool Curriculum KW - Self Concept KW - Disabilities KW - Federal Programs KW - Child Development KW - Alignment (Education) KW - Disadvantaged Youth KW - Social Development KW - Science Achievement KW - Literacy KW - Interpersonal Relationship KW - Preschool Children KW - School Readiness KW - Learning Strategies KW - Progress Monitoring KW - Low Income Groups KW - Educational Legislation KW - Social Studies KW - Physical Development KW - Emotional Development KW - Federal Legislation KW - English Language Learners KW - Receptive Language KW - Expressive Language KW - Self Efficacy KW - Psychomotor Skills KW - Art Activities KW - State Standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1651854718?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Population dynamics of Vibrio spp. associated with marine sponge microcosms AN - 1038594304; 16969341 AB - Vibrio is a diverse genus of marine-associated bacteria with at least 74 species and more expected as additional marine ecospheres are interrogated. This report describes a phylogenetic reconstruction of Vibrio isolates derived from one such unique ecosystem, marine sponges (Phylum Porifera) collected from depths of 150 to 1242 feet. 16S rRNA gene sequencing along with molecular typing of 16S-23S rRNA intergenic spacer regions clustered many sponge-associated Vibrio (spp) with current known species. That is, several benthic Vibrio species commensal with Porifera sponges seemed genetically linked to vibrios associated with coastal or shallow-water communities, signalling a panmictic population structure among seemingly ecologically disparate strains. Conversely, phylogenetic analysis provided evidence for at least two novel Vibrio speciation events within this specific sponge microcosm. Collectively, these findings earmark this still relatively unknown environment as a bastion of taxonomic and phylogenetic variability for the genus and probably other bacterial taxa. JF - ISME Journal AU - Hoffmann, Maria AU - Fischer, Markus AU - Ottesen, Andrea AU - McCarthy, Peter J AU - Lopez, Jose V AU - Brown, Eric W AU - Monday, Steven R AD - 1] Division of Microbiology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Paint Branch Parkway, College Park, MD, USA [2] Department of Chemistry, Institute of Food Chemistry, University of Hamburg, Grindelallee 117, Hamburg, Germany Y1 - 2010/12// PY - 2010 DA - December 2010 SP - 1608 EP - 1612 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 4 IS - 12 SN - 1751-7362, 1751-7362 KW - Microbiology Abstracts B: Bacteriology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Phylogeny KW - Marine KW - Speciation KW - Porifera KW - Commensals KW - Population dynamics KW - rRNA KW - Vibrio KW - Spacer region KW - Community composition KW - Typing KW - Shallow water KW - Population structure KW - Taxonomy KW - Microcosms KW - rRNA 16S KW - Phylogenetics KW - J 02310:Genetics & Taxonomy KW - O 5080:Legal/Governmental KW - Q1 08442:Population dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1038594304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISME+Journal&rft.atitle=Population+dynamics+of+Vibrio+spp.+associated+with+marine+sponge+microcosms&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BOttesen%2C+Andrea%3BMcCarthy%2C+Peter+J%3BLopez%2C+Jose+V%3BBrown%2C+Eric+W%3BMonday%2C+Steven+R&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-12-01&rft.volume=4&rft.issue=12&rft.spage=1608&rft.isbn=&rft.btitle=&rft.title=ISME+Journal&rft.issn=17517362&rft_id=info:doi/10.1038%2Fismej.2010.85 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-09-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Community composition; Shallow water; Commensals; Taxonomy; Population structure; Microcosms; Population dynamics; Phylogenetics; Phylogeny; rRNA; Speciation; Spacer region; Typing; rRNA 16S; Vibrio; Porifera; Marine DO - http://dx.doi.org/10.1038/ismej.2010.85 ER - TY - JOUR T1 - Interpreting Screening Questionnaires Specific Respiratory Symptoms and Their Relationship to Objective Test Results AN - 1020835896; 14292382 AB - Objective: To better delineate the relationship between responses to screening respiratory symptom questionnaires and various pulmonary function test results. Methods: Spirometry, methacholine challenge, standardized questionnaires, smoking, medical, and work histories were recorded at initial and 5-year follow-up surveys among 411 participants. Percent-predicted forced expiratory volume in 1 second (ppFEV sub(1)), 5-year FEV sub(1) decline, and proportion of methacholine responders (% hyper-responders) were compared with questionnaire responses utilizing generalized estimating equations modeling and analysis of variance. Results: Significant associations were found between ppFEV sub(1) and cough, phlegm, dyspnea, or ever wheezing; between greater percentage of hyper-responders and dyspnea with wheezing, ever/persistent wheezing, or history of asthma/hay fever; and between accelerated FEV sub(1) decline and new onset dyspnea with wheezing, phlegm, or persistent wheeze. Conclusions: Particular respiratory symptoms reported on screening questionnaires are associated with specific physiologic abnormalities, enhancing questionnaire utility in workplace health surveillance. JF - Journal of Occupational and Environmental Medicine AU - Petsonk, EL AU - Wang, M L AD - NIOSH, Mail Stop H-G900.2, 1095 Willowdale Road, Morgantown, WV 26505, USA, elp2@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1225 EP - 1229 VL - 52 IS - 12 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Asthma KW - Historical account KW - Respiratory diseases KW - Respiratory function KW - Smoking KW - Standards KW - hay fever KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020835896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Interpreting+Screening+Questionnaires+Specific+Respiratory+Symptoms+and+Their+Relationship+to+Objective+Test+Results&rft.au=Petsonk%2C+EL%3BWang%2C+M+L&rft.aulast=Petsonk&rft.aufirst=EL&rft.date=2010-12-01&rft.volume=52&rft.issue=12&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181fd728f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Smoking; Historical account; hay fever; Asthma; Standards; Respiratory function; Respiratory diseases DO - http://dx.doi.org/10.1097/JOM.0b013e3181fd728f ER - TY - JOUR T1 - Exposure to flour dust and sensitization among bakery employees AN - 1017966700; 16691605 AB - Background The National Institute for Occupational Safety and Health conducted a study to determine prevalences of sensitization to bakery-associated antigens (BAAs) and work-related respiratory symptoms at a large commercial bakery. Methods The following measurements were carried out: personal breathing zone (PBZ) and general area (GA) monitoring for inhalable flour dust, -amylase and wheat, a questionnaire, and blood tests for IgE specific to flour dust, wheat, -amylase, and common aeroallergens. Results Of 186 bakery employees present during our site visit, 161completed the questionnaire and 96 allowed their blood to be drawn. The geometric mean PBZ and GA inhalable flour dust concentrations for the lower-exposure group was 0.235 mg/m3, and for the higher-exposure group was 3.01 mg/m3. Employees in the higher-exposure group had significantly higher prevalences of work-related wheezing, runny nose, stuffy nose, and frequent sneezing than the lower-exposure group. The prevalence of IgE specific to wheat was significantly higher among employees who ever had a job in the higher-exposure group or in production at another bakery at both the >= 0.10 kU/L and the >= 0.35 kU/L cutoffs, and to flour dust and -amylase at the >= 0.10 kU/L cutoff, compared to the lower-exposure group. Conclusions Despite knowledge of the risks of exposure to flour being available for centuries, U.S. employees are still at risk of sensitization and respiratory symptoms from exposure to high levels of BAA. Am. J. Ind. Med. 53:1225-1232, 2010. ? 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Page, Elena H AU - Dowell Cih, Chad H AU - Mueller, Charles A AU - Biagini, Raymond E AU - Heederik, Dick AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, epage@cdc.gov Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 1225 EP - 1232 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 12 SN - 1097-0274, 1097-0274 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - wheat KW - Inhalation KW - Inventories KW - Respiration KW - Occupational safety KW - Wheezing KW - Dust KW - Triticum aestivum KW - Blood KW - USA KW - Immunoglobulin E KW - Allergens KW - Nose KW - Flour KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017966700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Exposure+to+flour+dust+and+sensitization+among+bakery+employees&rft.au=Page%2C+Elena+H%3BDowell+Cih%2C+Chad+H%3BMueller%2C+Charles+A%3BBiagini%2C+Raymond+E%3BHeederik%2C+Dick&rft.aulast=Page&rft.aufirst=Elena&rft.date=2010-12-01&rft.volume=53&rft.issue=12&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20893 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20893/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Inventories; Blood; Respiration; Allergens; Immunoglobulin E; Wheezing; Nose; Flour; Dust; Inhalation; wheat; Occupational safety; Triticum aestivum; USA DO - http://dx.doi.org/10.1002/ajim.20893 ER - TY - JOUR T1 - Effect of vaginal progesterone, administered to prevent preterm birth, on impedance to blood flow in fetal and uterine circulation AN - 1017962455; 16703937 AB - Objective To evaluate the effect on the maternal and fetal circulation of progesterone administered to prevent preterm birth. Methods We used an observational cohort study design. The study group included 44 women at 18-32 weeks' gestation who presented with an episode of preterm labor, with or without history of delivery before 34 weeks' gestation, or an incidental finding of short cervix (<= 25 mm). Doppler flow assessment of the umbilical artery, fetal middle cerebral artery and uterine arteries was performed before and 24 h after vaginal administration of progesterone. Results Seventeen (38.6%) women gave birth before term, but only nine (20.4%) did so before 34 weeks' gestation. Following progesterone treatment, there was a statistically significant decrease in the pulsatility index of the fetal middle cerebral artery (mean reduction, 18.2%; mean change in pulsatility index, 0.44 (95% CI, 0.25-0.63), P < 0.001), with no changes in the other vessels. Comparison of the women who gave birth before with those who delivered at term yielded no significant differences in Doppler flow parameters in any vessel examined, either before or after progesterone treatment. Conclusion Treatment with vaginal progesterone is associated with a lower pulsatility index in the fetal middle cerebral artery, suggesting a vasodilatory effect on the fetal circulation. JF - Ultrasound in Obstetrics and Gynecology AU - Barda, G AU - Ben-Haroush, A AU - Barkat, J AU - Malinger, G AU - Luria, O AU - Golan, A AU - Bar, J AD - Maternal-Fetal Medicine Unit, Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel, jbar@wolfson.health.gov.il Y1 - 2010/12// PY - 2010 DA - Dec 2010 SP - 743 EP - 748 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 36 IS - 6 SN - 1469-0705, 1469-0705 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Cervix KW - Fetuses KW - Gestation KW - Gynecology KW - Obstetrics KW - Progesterone KW - Statistical analysis KW - Ultrasound KW - Uterus KW - Vagina KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Effect+of+vaginal+progesterone%2C+administered+to+prevent+preterm+birth%2C+on+impedance+to+blood+flow+in+fetal+and+uterine+circulation&rft.au=Barda%2C+G%3BBen-Haroush%2C+A%3BBarkat%2C+J%3BMalinger%2C+G%3BLuria%2C+O%3BGolan%2C+A%3BBar%2C+J&rft.aulast=Barda&rft.aufirst=G&rft.date=2010-12-01&rft.volume=36&rft.issue=6&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=14690705&rft_id=info:doi/10.1002%2Fuog.7606 L2 - http://onlinelibrary.wiley.com/doi/10.1002/uog.7606/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Birth; Uterus; Gynecology; Progesterone; Vagina; Gestation; Statistical analysis; Cervix; Obstetrics; Ultrasound; Fetuses DO - http://dx.doi.org/10.1002/uog.7606 ER - TY - JOUR T1 - Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection AN - 851464652; 14023714 AB - A high-pressure liquid chromatography-diode array detection and multi-mode ionization tandem mass spectrometry (HPLC-DAD-MMI-MS/MS) method was used to identify amino-tadalafil and rimonabant in electronic cigarette (e-cigarette) cartridges. Amino-tadalafil is a drug analogue of the commercially approved Cialis[TM] (i.e. tadalafil). Rimonabant is a drug that was, at one time, approved for weight loss in Europe (although approval has been retracted), but not in the United States. In addition, poor quality control over the e-cigarette products analyzed here is shown by the presence of nicotine in products labeled as containing no nicotine or by the presence of significant amounts of rimonabant oxidative degradant in e-cigarette products containing rimonabant. Identification was accomplished by comparing the retention time of relevant peaks in the sample with those of standard compounds, in addition to comparison of the UV spectra, mass spectra and/or product ion mass spectra. JF - Journal of Chromatography A AU - Hadwiger, Michael E AU - Trehy, Michael L AU - Ye, Wei AU - Moore, Terry AU - Allgire, James AU - Westenberger, Benjamin AD - Food and Drug Administration, Division of Pharmaceutical Analysis, 1114 Market St., Saint Louis, MO 63101, USA, michael.hadwiger@fda.hhs.gov Y1 - 2010/11/26/ PY - 2010 DA - 2010 Nov 26 SP - 7547 EP - 7555 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 48 SN - 0021-9673, 0021-9673 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Water Resources Abstracts; Aqualine Abstracts; Toxicology Abstracts KW - E-cigarettes KW - Electronic cigarettes KW - HPLC KW - Mass spectrometry KW - Multi-mode ionization KW - MS KW - Rimonabant KW - Amino-tadalafil KW - Mass Spectrometry KW - Cigarettes KW - Chromatographic techniques KW - Europe KW - Mass spectroscopy KW - Mass Spectra KW - Weight KW - Nicotine KW - Ultraviolet radiation KW - Pressure KW - Quality Control KW - Drugs KW - Retention Time KW - USA KW - Liquid chromatography KW - Quality control KW - High Pressure KW - Standards KW - Ionization KW - SW 5010:Network design KW - X 24380:Social Poisons & Drug Abuse KW - Q5 08502:Methods and instruments KW - AQ 00002:Water Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851464652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Identification+of+amino-tadalafil+and+rimonabant+in+electronic+cigarette+products+using+high+pressure+liquid+chromatography+with+diode+array+and+tandem+mass+spectrometric+detection&rft.au=Fang%2C+Hong%3BXu%2C+Joshua%3BDing%2C+Don%3BJackson%2C+Scott+A%3BPatel%2C+Isha+R%3BFrye%2C+Jonathan+G%3BZou%2C+Wen%3BNayak%2C+Rajesh%3BFoley%2C+Steven%3BChen%2C+James%3BSu%2C+Zhenqiang%3BYe%2C+Yanbin%3BTurner%2C+Steve%3BHarris%2C+Steve%3BZhou%2C+Guangxu%3BCerniglia%2C+Carl%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Chromatographic techniques; Quality control; Ultraviolet radiation; Pressure; Drugs; Cigarettes; Liquid chromatography; Nicotine; Mass spectroscopy; Mass Spectrometry; Weight; Mass Spectra; Retention Time; High Pressure; Standards; Quality Control; Ionization; USA; Europe DO - http://dx.doi.org/10.1016/j.chroma.2010.10.018 ER - TY - JOUR T1 - Second Malignancy Risks After Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia: Differences by Lymphoma Subtype AN - 954606480; 14104669 AB - PURPOSE: Previous studies have shown increased risks of second malignancies after non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL); however, no earlier investigation has quantified differences in risk of new malignancy by lymphoma subtype. PATIENTS AND METHODS: We evaluated second cancer and leukemia risks among 43,145 1-year survivors of CLL/small lymphocytic lymphoma (SLL), diffuse large B-cell lymphoma (DLBCL), or follicular lymphoma (FL) from 11 Surveillance, Epidemiology, and End Results (SEER) population-based registries during 1992 to 2006. RESULTS: Among patients without HIV/AIDS-related lymphoma, lung cancer risks were significantly elevated after CLL/SLL and FL but not after DLBCL (standardized incidence ratio [SIR], CLL/SLL = 1.42, FL = 1.28, DLBCL = 1.00; Poisson regression P for difference among subtypes, PDiff = .001). A similar pattern was observed for risk of cutaneous melanoma (SIR: CLL/SLL = 1.92, FL = 1.60, DLBCL = 1.06; PDiff = .004). Acute nonlymphocytic leukemia risks were significantly elevated after FL and DLBCL, particularly among patients receiving initial chemotherapy, but not after CLL/SLL (SIR: CLL/SLL = 1.13, FL = 5.96, DLBCL = 4.96; PDiff < .001). Patients with HIV/AIDS-related lymphoma (n = 932) were predominantly diagnosed with DLBCL and had significantly and substantially elevated risks for second anal cancer (SIR = 120.50) and Kaposi's sarcoma (SIR = 138.90). CONCLUSION: Our findings suggest that differing immunologic alterations, treatments (eg, alkylating agent chemotherapy), genetic susceptibilities, and other risk factors (eg, viral infections, tobacco use) among lymphoma subtypes contribute to the patterns of second malignancy risk. Elucidating these patterns may provide etiologic clues to lymphoma as well as to the second malignancies. JF - Journal of Clinical Oncology AU - Morton, Lindsay M AU - Curtis, Rochelle E AU - Linet, Martha S AU - Bluhm, Elizabeth C AU - Tucker, Margaret A AU - Caporaso, Neil AU - Ries, Lynn AG AU - Fraumeni, Joseph F AD - From the Divisions of Cancer Epidemiology and Genetics, Rockville, MD, and of Cancer Control and Population Sciences, Bethesda, MD, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Y1 - 2010/11/20/ PY - 2010 DA - 2010 Nov 20 SP - 4935 EP - 4944 PB - American Society of Clinical Oncology VL - 28 IS - 33 SN - 0732-183X, 0732-183X KW - Immunology Abstracts; Toxicology Abstracts KW - Alkylating agents KW - B-cell lymphoma KW - double prime B-cell lymphoma KW - Chemotherapy KW - Melanoma KW - Non-Hodgkin's lymphoma KW - Malignancy KW - Epidemiology KW - Kaposi's sarcoma KW - Human immunodeficiency virus KW - Risk factors KW - Tobacco KW - Chronic lymphatic leukemia KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954606480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Second+Malignancy+Risks+After+Non-Hodgkin%27s+Lymphoma+and+Chronic+Lymphocytic+Leukemia%3A+Differences+by+Lymphoma+Subtype&rft.au=Morton%2C+Lindsay+M%3BCurtis%2C+Rochelle+E%3BLinet%2C+Martha+S%3BBluhm%2C+Elizabeth+C%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil%3BRies%2C+Lynn+AG%3BFraumeni%2C+Joseph+F&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2010-11-20&rft.volume=28&rft.issue=33&rft.spage=4935&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Alkylating agents; B-cell lymphoma; double prime B-cell lymphoma; Chemotherapy; Melanoma; Non-Hodgkin's lymphoma; Malignancy; Kaposi's sarcoma; Epidemiology; Risk factors; Tobacco; Chronic lymphatic leukemia; Lung cancer; Human immunodeficiency virus ER - TY - JOUR T1 - Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species AN - 849478017; 14025552 AB - Welding fumes consist of a wide range of complex metal oxide particles which can be deposited in all regions of the respiratory tract. The welding aerosol is not homogeneous and is generated mostly from the electrode/wire. Over 390,000 welders were reported in the U.S. in 2008 while over 1 million full-time welders were working worldwide. Many health effects are presently under investigation from exposure to welding fumes. Welding fume pulmonary effects have been associated with bronchitis, metal fume fever, cancer and functional changes in the lung. Our investigation focused on the generation of free radicals and reactive oxygen species from stainless and mild steel welding fumes generated by a gas metal arc robotic welder. An inhalation exposure chamber located at NIOSH was used to collect the welding fume particles. Our results show that hydroxyl radicals (.OH) were generated from reactions with H2O2 and after exposure to cells. Catalase reduced the generation of .OH from exposed cells indicating the involvement of H2O2. The welding fume suspension also showed the ability to cause lipid peroxidation, effect O2 consumption, induce H2O2 generation in cells, and cause DNA damage. Increase in oxidative damage observed in the cellular exposures correlated well with .OH generation in size and type of welding fumes, indicating the influence of metal type and transition state on radical production as well as associated damage. Our results demonstrate that both types of welding fumes are able to generate ROS and ROS-related damage over a range of particle sizes; however, the stainless steel fumes consistently showed a significantly higher reactivity and radical generation capacity. The chemical composition of the steel had a significant impact on the ROS generation capacity with the stainless steel containing Cr and Ni causing more damage than the mild steel. Our results suggest that welding fumes may cause acute lung injury. Since type of fume generated, particle size, and elapsed time after generation of the welding exposure are significant factors in radical generation and particle deposition these factors should be considered when developing protective strategies. JF - Particle and Fibre Toxicology AU - Leonard, Stephen S AU - Chen, Bean T AU - Stone, Samuel G AU - Schwegler-Berry, Diane AU - Kenyon, Allison J AU - Frazer, David AU - Antonini, James M AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2010/11/03/ PY - 2010 DA - 2010 Nov 03 SP - 32 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Inhalation KW - Injuries KW - Fever KW - Reactive oxygen species KW - Hydrogen peroxide KW - Welding KW - oxides KW - Bronchitis KW - Steel KW - Respiratory tract KW - Particle size KW - Metals KW - Aerosols KW - Fumes KW - Chromium KW - Free radicals KW - Catalase KW - Cancer KW - Lipid peroxidation KW - DNA damage KW - Lung KW - Electrodes KW - robotics KW - stainless steel KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849478017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Comparison+of+stainless+and+mild+steel+welding+fumes+in+generation+of+reactive+oxygen+species&rft.au=Leonard%2C+Stephen+S%3BChen%2C+Bean+T%3BStone%2C+Samuel+G%3BSchwegler-Berry%2C+Diane%3BKenyon%2C+Allison+J%3BFrazer%2C+David%3BAntonini%2C+James+M&rft.aulast=Leonard&rft.aufirst=Stephen&rft.date=2010-11-03&rft.volume=7&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-32 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Inhalation; Particle size; Metals; Aerosols; Fumes; Injuries; Chromium; Free radicals; Lipid peroxidation; Cancer; Catalase; Fever; DNA damage; Reactive oxygen species; Lung; Hydrogen peroxide; Electrodes; oxides; Welding; robotics; Bronchitis; Steel; stainless steel; Respiratory tract DO - http://dx.doi.org/10.1186/1743-8977-7-32 ER - TY - JOUR T1 - Concentration of metals in blood of Maine children 1-6 years old AN - 954606231; 14164371 AB - Blood lead concentrations are higher in young children than in other age groups, whereas little is known regarding concentrations of other metals in young children. We measured the concentrations of a suite of metals in the blood of children 1-6 years of age, and assessed potential differences by age, season, or region of Maine. We used blood submitted to the Maine State Health and Environmental Testing Laboratory for blood lead analysis to determine the concentrations of arsenic (As), antimony (Sb), cadmium (Cd), manganese (Mn), mercury (Hg), selenium (Se), tin (Sn), and uranium (U) in 1350 children 1-6 years of age. The essential metals Mn and Se were detected in all samples, and As and Sb were detected in >90% of samples. Hg was detected in approximately 60% of samples. U and Cd were less often detected in blood samples, at approximately 30% and 10% of samples, respectively. Sn was not detected in any sample. Concentrations of As, Hg, and Se increased with age, whereas Sb decreased with age. Concentrations also varied by season and region for some though not all metals. Significant pairwise correlations were observed for a number of metals. Blood is a reasonable compartment for measurement of most of these metals in young children. The use of convenience samples provided a cost-effective mechanism for assessing exposure of young children in Maine. JF - Journal of Exposure Science and Environmental Epidemiology AU - Rice, Deborah C AU - Lincoln, Rebecca AU - Martha, John AU - Parker, Lisa AU - Pote, Kenneth AU - Xing, Shuqin AU - Smith, Andrew E AD - Department of Health and Human Services, Environmental and Occupational Health Programs, Maine Center for Disease Control, Augusta, Maine, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 634 EP - 643 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 7 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts KW - Age KW - Heavy metals KW - Lead KW - Selenium KW - Uranium KW - Economics KW - Cadmium KW - Manganese KW - Metals KW - Arsenic KW - Children KW - Blood levels KW - Antimony KW - Mercury KW - USA, Maine KW - Tin KW - X 24390:Radioactive Materials KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954606231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Concentration+of+metals+in+blood+of+Maine+children+1-6+years+old&rft.au=Rice%2C+Deborah+C%3BLincoln%2C+Rebecca%3BMartha%2C+John%3BParker%2C+Lisa%3BPote%2C+Kenneth%3BXing%2C+Shuqin%3BSmith%2C+Andrew+E&rft.aulast=Rice&rft.aufirst=Deborah&rft.date=2010-11-01&rft.volume=20&rft.issue=7&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2010.42 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Selenium; Arsenic; Age; Heavy metals; Uranium; Antimony; Mercury; Cadmium; Tin; Children; Manganese; Lead; Metals; Economics; Blood levels; USA, Maine DO - http://dx.doi.org/10.1038/jes.2010.42 ER - TY - JOUR T1 - Pharmacogenomics and adverse drug reactions AN - 954603521; 14030346 AB - Adverse drug reactions (ADRs) observed during drug development have been the cause for discontinuing development of many drugs. In addition, serious but rare ADRs observed after marketing have led to withdrawal of some drugs. A priori identification of individuals at risk of developing ADRs for a given drug will help develop strategies to reduce the risk for ADRs in these patients. US FDA initiatives and efforts at reducing ADRs to make drugs safer are described, including updating of drug labels to include genomic information intended to reduce ADRs. Pharmacogenomics can also be harnessed to identify individuals at risk of developing serious ADRs and to treat these individuals with alternative therapy, thus converting ADRs that are traditionally considered unavoidable to avoidable ADRs. JF - Personalized Medicine AU - Amur, Shashi AU - Zineh, Issam AU - Abernethy, Darrell R AU - Huang, Shiew-Mei AU - Lesko, Lawrence J AD - super(1)Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, FDA, Building 51, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 633 EP - 642 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB UK VL - 7 IS - 6 SN - 1741-0541, 1741-0541 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - pharmacogenomics KW - Drug development KW - genomics KW - Drugs KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Pharmacogenomics+and+adverse+drug+reactions&rft.au=Amur%2C+Shashi%3BZineh%2C+Issam%3BAbernethy%2C+Darrell+R%3BHuang%2C+Shiew-Mei%3BLesko%2C+Lawrence+J&rft.aulast=Amur&rft.aufirst=Shashi&rft.date=2010-11-01&rft.volume=7&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/10.2217%2Fpme.10.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - pharmacogenomics; Drug development; genomics; Drugs DO - http://dx.doi.org/10.2217/pme.10.63 ER - TY - JOUR T1 - Edited by Peter M. Chapman, William J. Adams, Marjorie L. Brooks, Charles G. Delos, Samuel N. Luoma, William A. Maher, Harry M. Ohlendorf, Theresa S. Presser and D. Patrick Shaw, Ecological assessment of selenium in the aquatic environment, CRC Press, New York, 2010, 339 pp., (hardback) ISBN 978-1-4398-2677-5 AN - 883026682; 15241932 AB - Selenium is a naturally occurring essential element. Its concentration in the environment is increasing in the modern industrial world. Selenium can be a double-edged sword; it is not only beneficial for health, but also it can have adverse health effects. This book provides an in-depth ecological assessment of selenium in the aquatic environment. This comprehensive presentation with up-to-date information is the outcome of current developments in selenium research area. JF - Journal of Applied Toxicology AU - Us, Saura C Sahu Y1 - 2010/11// PY - 2010 DA - Nov 2010 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 8 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Edited+by+Peter+M.+Chapman%2C+William+J.+Adams%2C+Marjorie+L.+Brooks%2C+Charles+G.+Delos%2C+Samuel+N.+Luoma%2C+William+A.+Maher%2C+Harry+M.+Ohlendorf%2C+Theresa+S.+Presser+and+D.+Patrick+Shaw%2C+Ecological+assessment+of+selenium+in+the+aquatic+environment%2C+CRC+Press%2C+New+York%2C+2010%2C+339+pp.%2C+%28hardback%29+ISBN+978-1-4398-2677-5&rft.au=Us%2C+Saura+C+Sahu&rft.aulast=Us&rft.aufirst=Saura+C&rft.date=2010-11-01&rft.volume=30&rft.issue=8&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1568 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1568/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/jat.1568 ER - TY - RPRT T1 - FOREWORD AN - 878892486 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878892485 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 3,3',4,4'-TETRACHLOROAZOBENZENE (TCAB) [CAS NO. 14047-09-7] IN HARLAN SPRAGUE-DAWLEY RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878892484; 21383777 AB - 3,3',4,4' Tetrachloroazobenzene (TCAB) is formed as a by-product in the manufacture of a variety of herbicides. TCAB is structurally similar to TCDD, one of a large family of hydrocarbons containing chlorine known as dioxins. We studied the effects of TCAB on male and female rats and mice to identify potential toxic or carcinogenic hazards. We exposed groups of 50 male or female rats by depositing solutions of TCAB dissolved in corn oil through a tube directly into their stomachs five days a week for two years. Daily doses of TCDD were 10, 30, or 100 milligrams (mg) per kilogram of body weight. Similar groups of male or female mice received doses of 3, 10, or 30 mg/kg on the same schedule. Animals receiving corn oil alone served as the control group. Tissues from more than 40 sites were examined for every animal. Exposure to TCAB caused a variety of diseases in several organs. Cancers of the liver, lung, and mouth were seen in both male and female rats. Male rats also had increased rates of thyroid gland tumors and some female rats had tumors of the forestomach. Almost all exposed male mice developed carcinomas of the urethra. Both male and female mice also had a variety of tumors of the lung as well as cancers of the forestomach. Female mice also experienced cancers of the skin. A variety of other toxic effects were observed in exposed animals. In rats these included hypertrophy, hyperplasia, fibrosis, and necrosis of the liver; hyperplasia of the oral mucosa; metaplasia of the lung; inflammation and atrophy of the pancreas; and other nonneoplastic lesions of the forestomach, adrenal cortex, blood vessel, spleen, and mesenteric lymph node. In mice observed adverse outcomes included cardiomyopathy of the heart; atrophy of the thymus; hyperplasia of the skin, urinary bladder, forestomach and glandular stomach; and other nonneoplastic lesions of the spleen, liver, urethra, ureter, blood vessel, clitoral gland, ovary, and bone marrow. We conclude that TCAB caused cancer and other toxic effects at several sites in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 EP - 206 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Azo Compounds KW - Chlorobenzenes KW - 3,4,3',4'-tetrachloroazobenzene KW - By products KW - Toxicology KW - Carcinogens KW - Health hazards KW - Rodents KW - Herbicides KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Humans KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Organ Size -- drug effects KW - Chlorobenzenes -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Azo Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878892484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+3%2C3%27%2C4%2C4%27-TETRACHLOROAZOBENZENE+%28TCAB%29+%5BCAS+NO.+14047-09-7%5D+IN+HARLAN+SPRAGUE-DAWLEY+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=558&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683498 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683495 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 3 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,3',4,4',5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) AN - 878683472; 21383778 AB - 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) is one of a large family of hydrocarbons containing chlorine (PCBs) that are similar in structure to dioxins. Some dioxins or dioxin-like compounds are highly toxic and cause cancer, and usually contaminated sites contain many different varieties of these dioxin-like compounds. The National Toxicology Program conducted a series of studies to try to gauge the relative toxicity of some of the more prevalent of these compounds, both alone and in mixtures. This study evaluated the effects of PCB 118 on female rats for comparison with the potency of other chemicals in that family. We exposed groups of 50 female rats by depositing solutions of PCB 118 dissolved in corn oil through a tube directly into their stomachs 5 days a week for 2 years. Daily doses of PCB 118 were 100, 220, 460, 1,000, or 4,600 micrograms (µg) per kilogram of body weight. Tissues from more than 40 sites were examined for every animal. Exposure to PCB 118 caused a variety of diseases in several organs. Cancers of the liver, lung, uterus, and pancreas were seen in female rats exposed to PCB 118. A variety of other toxic lesions observed in exposed animals included hypertrophy, hyperplasia, fibrosis, and toxic hepatopathy of the liver, metaplasia of the lung, atrophy of the adrenal cortex, inflammation and cytoplasmic vacuolization of the pancreas, and hypertrophy of the thyroid gland. We conclude that PCB 118 caused cancer of the liver, lung, and uterus and possibly of the pancreas plus a variety of other toxic effects at several sites in female rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1 EP - 174 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - 2,3',4,4',5-pentachlorobiphenyl KW - Polychlorinated Biphenyls KW - Tetrachlorodibenzodioxin KW - Hydrocarbons KW - Polychlorinated biphenyls--PCB KW - Toxicology KW - Rodents KW - Cancer KW - Tetrachlorodibenzodioxin -- toxicity KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Polychlorinated Biphenyls -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+2%2C3%27%2C4%2C4%27%2C5-PENTACHLOROBIPHENYL+%28PCB+118%29+%28CAS+NO.+31508-00-6%29+IN+FEMALE+HARLAN+SPRAGUE-DAWLEY+RATS+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2010 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Stochastic modeling of gob gas venthole production performances in active and completed longwall panels of coal mines AN - 877845290; 2011-058210 AB - Gob gas ventholes (GGVs) are an integral part of longwall coal mining operations, enhancing safety by controlling methane in underground workings. As in many disciplines in earth sciences, uncertainties due to the heterogeneity of geologic formations exist. These uncertainties, and the wide range of mining and venthole operation parameters, lead to performance variability in GGVs. Random variations in parameters affecting GGV performance and influencing parameters that cannot be quantified sufficiently due to lack of information limit deterministic GGV models and even introduce error in severe cases. Therefore, evaluation of GGV performance data and the uncertainty in input parameters is valuable for understanding the variability in GGV production and for designing them accordingly. This paper describes a practical approach for implementing stochastic determination of GGV production performances and for generalizing the prediction capability of deterministic models. Deterministic site-specific models were derived by using the GGV module in the recently developed MCP (Methane Control and Prediction) software suite. These models were generated using multi-parameter regression techniques and were then improved by inclusion of extra input parameters that eliminated the site dependency and improved the predictions. Statistical distributions of input parameters in these models were quantified and tested with the Kolmogorov-Smirnov goodness-of-fit technique. Next, Monte Carlo simulations were performed using these distributions and generalized results for GGV performances were generated. The results of this work indicate that this approach is a promising method of representing the variability in GGV performances and to improve the limited and site-specific character of the deterministic models. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Luxbacher, Kray Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 125 EP - 140 PB - Elsevier, Amsterdam VL - 84 IS - 2 SN - 0166-5162, 0166-5162 KW - mining KW - mines KW - underground mining KW - natural gas KW - Monte Carlo analysis KW - statistical analysis KW - data processing KW - coal mines KW - prediction KW - petroleum KW - mathematical models KW - production KW - ventilation KW - longwall mining KW - stochastic processes KW - digital simulation KW - coalbed methane KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877845290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Stochastic+modeling+of+gob+gas+venthole+production+performances+in+active+and+completed+longwall+panels+of+coal+mines&rft.au=Karacan%2C+C+Ozgen%3BLuxbacher%2C+Kray&rft.aulast=Karacan&rft.aufirst=C&rft.date=2010-11-01&rft.volume=84&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.09.001 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. 9 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - coal mines; coalbed methane; data processing; digital simulation; longwall mining; mathematical models; mines; mining; Monte Carlo analysis; natural gas; petroleum; prediction; production; statistical analysis; stochastic processes; underground mining; ventilation DO - http://dx.doi.org/10.1016/j.coal.2010.09.001 ER - TY - JOUR T1 - Measurement of multiple drugs in urine, water, and on surfaces using fluorescence covalent microbead immunosorbent assay AN - 874193062; 14972706 AB - There are a range of applications that require the measurement of multiple drugs such as urine analysis, drug determination in water, and screening for drug contamination on surfaces. Some of the procedures used such as enzyme-linked immunosorbent assay (ELISA) are simple but can only determine one drug at a time, and others such as GC-MS or LC-MS are complex, time-consuming, and expensive. In this study, fluorescence covalent microbead immunosorbent assay (FCMIA) was investigated as a simple method for the measurement of multiple drugs simultaneously in three matrices: diluted urine, water, and on surfaces. Five different drugs of abuse or their metabolites (methamphetamine, caffeine, benzoylecgonine (a metabolite of cocaine), tetrahydrocannabinol (THC), the active ingredient in marijuana, and oxycodone) were studied over the range 0-15 ng/ml. There was no measureable cross-reactivity among the drugs at the concentrations studied. Urine dilutions from 1/50 to 1/2.5 were studied and dilutions less than 1/20 had a significant effect on the methamphetamine assay but limited effects on the benzoylecgonine and oxycodone assays and almost no effect on the THC assay. For assays performed in 1/20 urine dilution, water, and diluted surface sampling buffer, least detectable doses (LDD) were 1 ng/ml or less for the drugs. Surfaces spiked with drugs were sampled with swabs wetted with surface sampling buffer and recoveries were linear over the range 0-100 ng/100 cm super(2) surface loading for all drugs. FCMIA has potential to be used for the measurement of multiple drugs in the matrices studied. JF - Toxicology Mechanisms and Methods AU - Smith, J AU - Sammons, D AU - Robertson, S AU - Biagini, R AU - Snawder, J AD - Biomonitoring Research Team, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA, jps3@cdc.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 587 EP - 593 VL - 20 IS - 9 SN - 1537-6516, 1537-6516 KW - Environment Abstracts; Toxicology Abstracts KW - Cross-reactivity KW - Contamination KW - Surface water KW - buffers KW - Metabolites KW - oxycodone KW - Drug abuse KW - Drug screening KW - Immunosorbents KW - Cannabis KW - Caffeine KW - Sampling KW - Cocaine KW - Drugs KW - methamphetamine KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - cocaine KW - Tetrahydrocannabinol KW - Methamphetamine KW - Urine KW - microspheres KW - Immunoassays KW - X 24380:Social Poisons & Drug Abuse KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874193062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Measurement+of+multiple+drugs+in+urine%2C+water%2C+and+on+surfaces+using+fluorescence+covalent+microbead+immunosorbent+assay&rft.au=Smith%2C+J%3BSammons%2C+D%3BRobertson%2C+S%3BBiagini%2C+R%3BSnawder%2C+J&rft.aulast=Smith&rft.aufirst=J&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518172 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Fluorescence; Cross-reactivity; Contamination; Metabolites; Drug screening; Drug abuse; oxycodone; Immunosorbents; Tetrahydrocannabinol; Methamphetamine; Urine; microspheres; Cannabis; Caffeine; Sampling; Cocaine; Surface water; cocaine; buffers; Immunoassays; Drugs; methamphetamine DO - http://dx.doi.org/10.3109/15376516.2010.518172 ER - TY - JOUR T1 - Partition coefficients for nonane and its isomers in the rat AN - 874190796; 14972707 AB - Jet Fuel 8 (JP-8) is a major fuel source used by US and NATO military. JP-8 is a complex mixture of aliphatic and aromatic isomers of hydrocarbons. Tissue/blood partition coefficient (PC) values are chemical-specific parameters used in modeling the kinetic behavior of chemicals. The partition coefficient values for n-alkanes tend to increase with the increasing carbon number, but less is known about the trend for isomers of n-alkanes. PC values were obtained for the n-alkane nonane (C9) and five of its isomers, namely 3-methyloctane, 4-ethylheptane, 2, 3-dimethylheptane, 2, 2, 4-trimethylhexane, 2, 2, 4, 4-tetramethylpentane. The blood:air and tissue:air PC values correlated with the published log octanol/water (O:W) PC values for n-nonane and its isomers. Experimentally determined blood:air and tissue:air PC values for n-nonane with the largest O:W value were greatest and smallest for the isomer 2, 2, 4, 4-tetramethylpentane with the lowest O:W value. As expected the fat tissue had the highest PC values and muscle the lowest for n-nonane and its isomers. For each tissue, a linear relationship was observed between the tissue/blood PC values for the isomers of n-nonane and n-nonane. This suggests that tissue/blood PC values for all isomers of an alkane could be estimated using data collected from only a sub-set of alkanes of equal carbon number. These reported tissue/blood PC values will support the development of a jet fuel physiologically-based pharmacokinetic (PBPK) model. JF - Toxicology Mechanisms and Methods AU - Joshi, G AU - Tremblay, R T AU - Martin, SA AU - Fisher, J W AD - FDA/NCTR, 3900 NCTR Road, Jefferson, AR, USA, jeffrey.fisher@hhs.fda.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 594 EP - 599 VL - 20 IS - 9 SN - 1537-6516, 1537-6516 KW - Environment Abstracts; Toxicology Abstracts KW - Chemicals KW - Fuels KW - Models KW - Isomers KW - Carbon KW - octanol KW - Military KW - Alkanes KW - Data processing KW - Hydrocarbons KW - Muscles KW - N-Alkanes KW - Pharmacokinetics KW - Blood KW - Kinetics KW - aromatic hydrocarbons KW - Aromatics KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874190796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Partition+coefficients+for+nonane+and+its+isomers+in+the+rat&rft.au=Joshi%2C+G%3BTremblay%2C+R+T%3BMartin%2C+SA%3BFisher%2C+J+W&rft.aulast=Joshi&rft.aufirst=G&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alkanes; Data processing; Hydrocarbons; Fuels; Muscles; N-Alkanes; Pharmacokinetics; Isomers; Models; Blood; Carbon; octanol; Kinetics; Aromatics; Chemicals; Military; aromatic hydrocarbons DO - http://dx.doi.org/10.3109/15376516.2010.518175 ER - TY - JOUR T1 - The Antioxidant Transcription Factor Nrf2 Negatively Regulates Autophagy and Growth Arrest Induced by the Anticancer Redox Agent Mitoquinone AN - 864953652; 13932401 AB - Mitoquinone (MitoQ) is a synthetically modified, redox-active ubiquinone compound that accumulates predominantly in mitochondria. We found that MitoQ is 30-fold more cytotoxic to breast cancer cells than to healthy mammary cells. MitoQ treatment led to irreversible inhibition of clonogenic growth of breast cancer cells through a combination of autophagy and apoptotic cell death mechanisms. Relatively limited cytotoxicity was seen with the parent ubiquinone coenzyme Q sub(10.) Inhibition of cancer cell growth by MitoQ was associated with G sub(1)/S cell cycle arrest and phosphorylation of the checkpoint kinases Chk1 and Chk2. The possible role of oxidative stress in MitoQ activity was investigated by measuring the products of hydroethidine oxidation. Increases in ethidium and dihydroethidium levels, markers of one-electron oxidation of hydroethidine, were observed at cytotoxic concentrations of MitoQ. Keap1, an oxidative stress sensor protein that regulates the antioxidant transcription factor Nrf2, underwent oxidation, degradation, and dissociation from Nrf2 in MitoQ-treated cells. Nrf2 protein levels, nuclear localization, and transcriptional activity also increased following MitoQ treatment. Knockdown of Nrf2 caused a 2-fold increase in autophagy and an increase in G sub(1) cell cycle arrest in response to MitoQ but had no apparent effect on apoptosis. The Nrf2-regulated enzyme NQO1 is partly responsible for controlling the level of autophagy. Keap1 and Nrf2 act as redox sensors for oxidative perturbations that lead to autophagy. MitoQ and similar compounds should be further evaluated for novel anticancer activity. JF - Journal of Biological Chemistry AU - Rao, VAshutosh AU - Klein, Sarah R AU - Bonar, Spencer J AU - Zielonka, Jacek AU - Mizuno, Naoko AU - Dickey, Jennifer S AU - Keller, Paul W AU - Joseph, Joy AU - Kalyanaraman, Balaraman AU - Shacter, Emily AD - Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 34447 EP - 34459. PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 45 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - CHK2 protein KW - Antioxidants KW - Apoptosis KW - Cell cycle KW - Enzymes KW - Mitochondria KW - NRF2 protein KW - Coenzyme Q10 KW - Cytotoxicity KW - Phosphorylation KW - ubiquinone KW - Oxidative stress KW - Transcription factors KW - Breast cancer KW - NAD(P)H dehydrogenase (quinone) KW - CHK1 protein KW - Phagocytosis KW - Antitumor activity KW - N 14835:Protein-Nucleic Acids Association KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864953652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Antioxidant+Transcription+Factor+Nrf2+Negatively+Regulates+Autophagy+and+Growth+Arrest+Induced+by+the+Anticancer+Redox+Agent+Mitoquinone&rft.au=Rao%2C+VAshutosh%3BKlein%2C+Sarah+R%3BBonar%2C+Spencer+J%3BZielonka%2C+Jacek%3BMizuno%2C+Naoko%3BDickey%2C+Jennifer+S%3BKeller%2C+Paul+W%3BJoseph%2C+Joy%3BKalyanaraman%2C+Balaraman%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=VAshutosh&rft.date=2010-11-01&rft.volume=285&rft.issue=45&rft.spage=34447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.133579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - CHK2 protein; Apoptosis; Antioxidants; Cell cycle; NRF2 protein; Mitochondria; Enzymes; Coenzyme Q10; Cytotoxicity; Phosphorylation; Oxidative stress; ubiquinone; Transcription factors; Breast cancer; CHK1 protein; NAD(P)H dehydrogenase (quinone); Phagocytosis; Antitumor activity DO - http://dx.doi.org/10.1074/jbc.M110.133579 ER - TY - JOUR T1 - Unhealthy and Uninsured: Exploring Racial Differences in Health and Health Insurance Coverage Using A Life Table Approach AN - 856405082; 201108185 AB - Millions of people in the United States do not have health insurance, and wide racial and ethnic disparities exist in coverage. Current research provides a limited description of this problem, focusing on the number or proportion of individuals without insurance at a single time point or for a short period. Moreover, the literature provides no sense of the joint risk of being uninsured and in need of medical care. In this article, we use a life table approach to calculate health- and insurance-specific life expectancies for whites and blacks, thereby providing estimates of the duration of exposure to different insurance and health states over a typical lifetime. We find that, on average, Americans can expect to spend well over a decade without health insurance during a typical lifetime and that 40% of these years are spent in less-healthy categories. Findings also reveal a significant racial gap: despite their shorter overall life expectancy, blacks have a longer uninsured life expectancy than whites, and this racial gap consists entirely of less-healthy years. Racial disparities in insurance coverage are thus likely more severe than indicated by previous research. Adapted from the source document. JF - Demography AU - Kirby, James B AU - Kaneda, Toshiko AD - The Agency for Healthcare Research and Quality, Center for Financing, Access, and Cost Trends, 540 Gaither Road, Rockville, MD 20850 jkirby@ahrq.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 1035 EP - 1051 PB - Population Association of America, Silver Spring MD VL - 47 IS - 4 SN - 0070-3370, 0070-3370 KW - Life Tables KW - Health Insurance KW - Health Problems KW - United States of America KW - Racial Differences KW - Longevity KW - article KW - 1837: demography and human biology; demography (population studies) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856405082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Demography&rft.atitle=Unhealthy+and+Uninsured%3A+Exploring+Racial+Differences+in+Health+and+Health+Insurance+Coverage+Using+A+Life+Table+Approach&rft.au=Kirby%2C+James+B%3BKaneda%2C+Toshiko&rft.aulast=Kirby&rft.aufirst=James&rft.date=2010-11-01&rft.volume=47&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Demography&rft.issn=00703370&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2011-03-07 N1 - Number of references - 56 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health Insurance; Longevity; Racial Differences; Life Tables; Health Problems; United States of America ER - TY - JOUR T1 - Multiple Antigen Peptide Vaccines against Plasmodium falciparum Malaria AN - 853475925; 13885345 AB - The multiple antigen peptide (MAP) approach is an effective method to chemically synthesize and deliver multiple T-cell and B-cell epitopes as the constituents of a single immunogen. Here we report on the design, chemical synthesis, and immunogenicity of three Plasmodium falciparum MAP vaccines that incorporated antigenic epitopes from the sporozoite, liver, and blood stages of the life cycle. Antibody and cellular responses were determined in three inbred (C57BL/6, BALB/c, and A/J) strains, one congenic (HLA-A2 on the C57BL/6 background) strain, and one outbred strain (CD1) of mice. All three MAPs were immunogenic and induced both antibody and cellular responses, albeit in a somewhat genetically restricted manner. Antibodies against MAP-1, MAP-2, and MAP-3 had an antiparasite effect that was also dependent on the mouse major histocompatibility complex background. Anti-MAP-1 (CSP-based) antibodies blocked the invasion of HepG2 liver cells by P. falciparum sporozoites (highest, 95.16% in HLA-A2 C57BL/6; lowest, 11.21% in BALB/c). Furthermore, antibodies generated following immunizations with the MAP-2 (PfCSP, PfLSA-1, PfMSP-142, and PfMSP-3b) and MAP-3 (PfRAP-1, PfRAP-2, PfSERA, and PfMSP-142) vaccines were able to reduce the growth of blood stage parasites in erythrocyte cultures to various degrees. Thus, MAP-based vaccines remain a viable option to induce effective antibody and cellular responses. These results warrant further development and preclinical and clinical testing of the next generation of candidate MAP vaccines that are based on the conserved protective epitopes from Plasmodium antigens that are widely recognized by populations of divergent HLA types from around the world. JF - Infection and Immunity AU - Mahajan, Babita AU - Berzofsky, Jay A AU - Boykins, Robert A AU - Majam, Victoria AU - Zheng, Hong AU - Chattopadhyay, Rana AU - la Vega, Patricia de AU - Moch, JKathleen AU - Haynes, JDavid AU - Belyakov, Igor M AD - Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, Sanjai.kumar@fda.hhs.gov Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 4613 EP - 4624 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 78 IS - 11 SN - 0019-9567, 0019-9567 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Parasites KW - Hepatocytes KW - Erythrocytes KW - Disease control KW - Life cycle KW - Major histocompatibility complex KW - Cell culture KW - Malaria KW - Public health KW - Antigens KW - Lymphocytes T KW - Epitopes KW - Lymphocytes B KW - Sporozoites KW - Plasmodium falciparum KW - Immunization KW - Blood KW - Antibodies KW - Immunogenicity KW - Liver KW - Inbreeding KW - Peptides KW - Vaccines KW - K 03350:Immunology KW - Q1 08485:Species interactions: pests and control KW - F 06910:Microorganisms & Parasites KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853475925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Folotyn+%28pralatrexate+injection%29+for+the+treatment+of+patients+with+relapsed+or+refractory+peripheral+T-cell+lymphoma%3A+U.S.+Food+and+Drug+Administration+drug+approval+summary.&rft.au=Malik%2C+Shakun+M%3BLiu%2C+Ke%3BQiang%2C+Xu%3BSridhara%2C+Rajeshwari%3BTang%2C+Shenghui%3BMcGuinn%2C+W+David%3BVerbois%2C+S+Leigh%3BMarathe%2C+Anshu%3BWilliams%2C+Gene+M%3BBullock%2C+Julie%3BTornoe%2C+Christoffer%3BLin%2C+Sue+Ching%3BOcheltree%2C+Terrance%3BVialpando%2C+Milinda%3BKacuba%2C+Alice%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Malik&rft.aufirst=Shakun&rft.date=2010-10-15&rft.volume=16&rft.issue=20&rft.spage=4921&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-10-1214 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Number of references - 63 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Antigens; Disease control; Peptides; Vaccines; Public health; Histocompatibility antigen HLA; Lymphocytes B; Hepatocytes; Erythrocytes; Sporozoites; Major histocompatibility complex; Life cycle; Malaria; Cell culture; Immunization; Blood; Immunogenicity; Liver; Lymphocytes T; Inbreeding; Epitopes; Plasmodium falciparum DO - http://dx.doi.org/10.1128/IAI.00533-10 ER - TY - JOUR T1 - Thresholds for nonlinear effects in high- intensity focused ultrasound propagation and tissue heating AN - 849447213; 13916157 AB - For a variety of reasons, including their simplicity and ability to capitalize upon superposition, linear acoustic propagation models are preferable to nonlinear ones in modeling the propagation of high-intensity focused ultrasound (HIFU) beams. However, under certain conditions, nonlinear models are necessary to accurately model the beam propagation and heating. In analyzing the performance of a HIFU system, it is advantageous to know before the analysis whether a linear model suffices. This paper examines the problem of determining the thresholds at which nonlinear effects become important. It is demonstrated that nonlinear interaction has different effects on different physical and derived quantities, such as compressional pressure, rarefactional pressure, intensity, heat rate, temperature rise, and thermal lesion volume. Thresholds are determined as a function of the dimensionless gain, nonlinearity, and absorption parameters. The relative difference between linear and nonlinear predictions is plotted as a series of contours, enabling practicioners to locate their system in parameter space and determine whether nonlinearity significantly affects the quantities of interest. JF - IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control AU - Soneson, Joshua E AU - Myers, Matthew R AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 2450 EP - 2459 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 57 IS - 11 SN - 0885-3010, 0885-3010 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Acoustics KW - Ultrasonics KW - nonlinear systems KW - Pressure KW - Ultrasound KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849447213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Ultrasonics%2C+Ferroelectrics+and+Frequency+Control&rft.atitle=Thresholds+for+nonlinear+effects+in+high-+intensity+focused+ultrasound+propagation+and+tissue+heating&rft.au=Soneson%2C+Joshua+E%3BMyers%2C+Matthew+R&rft.aulast=Soneson&rft.aufirst=Joshua&rft.date=2010-11-01&rft.volume=57&rft.issue=11&rft.spage=2450&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Ultrasonics%2C+Ferroelectrics+and+Frequency+Control&rft.issn=08853010&rft_id=info:doi/10.1109%2FTUFFC.2010.1711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ultrasonics; Acoustics; nonlinear systems; Pressure; Ultrasound; Models DO - http://dx.doi.org/10.1109/TUFFC.2010.1711 ER - TY - JOUR T1 - Antioxidants and Pulmonary Function Among Police Officers AN - 839706499; 14029607 AB - Objective: To examine associations of dietary antioxidant intake and pulmonary function. Methods: Antioxidant data (vitamins A, C, D, E, magnesium, and omega-3 fatty acids) were abstracted from food frequency questionnaires. Pulmonary function was measured using American Thoracic Society criteria. We used analysis of variance to investigate associations. Results: Among 79 police officers (57% male), forced vital capacity was positively and significantly associated with vitamin A after adjustment for age, gender, height, race, smoking status, and pack-years of smoking, and with magnesium after adjustment for those risk factors plus total calories, all supplement use, and abdominal height. Among current/former smokers only, mean levels of all pulmonary function measures were significantly associated with vitamin E; smoking status significantly modified these relationships. Conclusions: Increased intake of vitamin A, vitamin E (among current/former smokers only), and magnesium was associated with better pulmonary function. JF - Journal of Occupational and Environmental Medicine AU - Charles, LE AU - Burchfiel, C M AU - Mnatsakanova, A AU - Fekedulegn, D AU - Tinney-Zara, C AU - Joseph, P N AU - Schunemann, HJ AU - Violanti, J M AU - Andrew, ME AU - Ochs-Balcom, H M AD - National Institute for Occupational Safety and Health, HELD/BEB, MailStop L-4050, 1095 Willowdale Rd., Morgantown, WV 26505-2888, USA, lcharles@cdc.gov Y1 - 2010/11// PY - 2010 DA - Nov 2010 SP - 1124 EP - 1131 VL - 52 IS - 11 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Diets KW - Antioxidants KW - Smoking KW - vitamins KW - police KW - Gender KW - Fatty acids KW - Respiratory function KW - Magnesium KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839706499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Antioxidants+and+Pulmonary+Function+Among+Police+Officers&rft.au=Charles%2C+LE%3BBurchfiel%2C+C+M%3BMnatsakanova%2C+A%3BFekedulegn%2C+D%3BTinney-Zara%2C+C%3BJoseph%2C+P+N%3BSchunemann%2C+HJ%3BViolanti%2C+J+M%3BAndrew%2C+ME%3BOchs-Balcom%2C+H+M&rft.aulast=Charles&rft.aufirst=LE&rft.date=2010-11-01&rft.volume=52&rft.issue=11&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181f7cb4c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Antioxidants; vitamins; police; Gender; Fatty acids; Respiratory function; Magnesium DO - http://dx.doi.org/10.1097/JOM.0b013e3181f7cb4c ER - TY - JOUR T1 - Detection and confirmation of Clostridium botulinum in water used for cooling at a plant producing low-acid canned foods. AN - 763165490; 20889791 AB - Our laboratory tested water samples used for cooling low-acid canned foods at a canning facility under investigation by the U.S. Food and Drug Administration. We used an enzyme-linked immunosorbent assay with digoxigenin-labeled antibodies (DIG-ELISA) and real-time PCR as screening methods and confirmed the presence of neurotoxin-producing Clostridium botulinum in the samples by mouse bioassay. JF - Applied and environmental microbiology AU - Sachdeva, Amita AU - Defibaugh-Chávez, Stephanie L H AU - Day, James B AU - Zink, Donald AU - Sharma, Shashi K AD - FDA, Center for Food Safety and Applied Nutrition, College Park, MD 20740, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 7653 EP - 7657 VL - 76 IS - 22 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Index Medicus KW - United States KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Botulism -- diagnosis KW - Animals KW - Polymerase Chain Reaction -- methods KW - Bacteriological Techniques -- methods KW - Disease Models, Animal KW - Botulinum Toxins -- biosynthesis KW - Mice KW - Botulism -- pathology KW - Mass Screening -- methods KW - Food, Preserved KW - Clostridium botulinum -- isolation & purification KW - Water Microbiology KW - Food Industry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763165490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Detection+and+confirmation+of+Clostridium+botulinum+in+water+used+for+cooling+at+a+plant+producing+low-acid+canned+foods.&rft.au=Sachdeva%2C+Amita%3BDefibaugh-Ch%C3%A1vez%2C+Stephanie+L+H%3BDay%2C+James+B%3BZink%2C+Donald%3BSharma%2C+Shashi+K&rft.aulast=Sachdeva&rft.aufirst=Amita&rft.date=2010-11-01&rft.volume=76&rft.issue=22&rft.spage=7653&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00820-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-22 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochemistry. 2000 Mar 7;39(9):2399-405 [10694409] J Nat Toxins. 2000 Nov;9(4):357-62 [11126514] J Clin Microbiol. 2004 Apr;42(4):1713-5 [15071029] J Infect Dis. 1981 Jan;143(1):22-7 [7012244] J Clin Microbiol. 1985 Jun;21(6):947-50 [3891773] J Protein Chem. 1995 Jan;14(1):7-18 [7779263] Appl Environ Microbiol. 2006 Feb;72(2):1231-8 [16461671] J Protein Chem. 1998 Jan;17(1):53-60 [9491928] Ann Intern Med. 1998 Aug 1;129(3):221-8 [9696731] Curr Microbiol. 1998 Nov;37(5):312-8 [9767710] J Protein Chem. 1999 Jan;18(1):29-38 [10071926] Foodborne Pathog Dis. 2004 Winter;1(4):247-57 [15992287] Toxicon. 1995 Dec;33(12):1541-7 [8866611] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.00820-10 ER - TY - JOUR T1 - Evaluation of virulence factor profiling in the characterization of veterinary Escherichia coli isolates. AN - 763165458; 20889790 AB - Escherichia coli has been used as an indicator organism for fecal contamination of water and other environments and is often a commensal organism in healthy animals, yet a number of strains can cause disease in young or immunocompromised animals. In this study, 281 E. coli isolates from bovine, porcine, chicken, canine, equine, feline, and other veterinary sources were analyzed by BOXA1R PCR and by virulence factor profiling of 35 factors to determine whether they had utility in identifying the animal source of the isolates. The results of BOXA1R PCR analysis demonstrated a high degree of diversity; less than half of the isolates fell into one of 27 clusters with at least three isolates (based on 90% similarity). Nearly 60% of these clusters contained isolates from more than one animal source. Conversely, the results of virulence factor profiling demonstrated clustering by animal source. Three clusters, named Bovine, Chicken, and Porcine, based on discriminant components analysis, were represented by 90% or more of the respective isolates. A fourth group, termed Companion, was the most diverse, containing at least 84% of isolates from canine, feline, equine, and other animal sources. Based on these results, it appears that virulence factor profiling may have utility, helping identify the likely animal host species sources of certain E. coli isolates. JF - Applied and environmental microbiology AU - David, Donna E AU - Lynne, Aaron M AU - Han, Jing AU - Foley, Steven L AD - National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 7509 EP - 7513 VL - 76 IS - 22 KW - Escherichia coli Proteins KW - 0 KW - Virulence Factors KW - Index Medicus KW - Animals, Domestic KW - Genetic Variation KW - Animals KW - Polymerase Chain Reaction -- methods KW - Bacteriological Techniques -- methods KW - Bacterial Typing Techniques KW - Cluster Analysis KW - Escherichia coli Infections -- microbiology KW - Escherichia coli Infections -- veterinary KW - Escherichia coli -- isolation & purification KW - Escherichia coli -- pathogenicity KW - Escherichia coli -- genetics KW - Virulence Factors -- genetics KW - Escherichia coli Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/763165458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Evaluation+of+virulence+factor+profiling+in+the+characterization+of+veterinary+Escherichia+coli+isolates.&rft.au=David%2C+Donna+E%3BLynne%2C+Aaron+M%3BHan%2C+Jing%3BFoley%2C+Steven+L&rft.aulast=David&rft.aufirst=Donna&rft.date=2010-11-01&rft.volume=76&rft.issue=22&rft.spage=7509&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00726-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-22 N1 - Date created - 2010-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 2004 Oct 22-Nov 26;67(20-22):1879-87 [15371222] J Clin Microbiol. 2003 Sep;41(9):4480-2 [12958300] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4641-5 [9539791] J Clin Microbiol. 1999 Jun;37(6):1661-9 [10325304] Epidemiol Infect. 1999 Aug;123(1):17-24 [10487637] Vet Res. 2005 Mar-Apr;36(2):241-56 [15720976] Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5564-9 [15809431] Can J Microbiol. 2005 Jun;51(6):501-5 [16121229] J Microbiol Methods. 2005 Nov;63(2):135-44 [15893395] Appl Environ Microbiol. 2005 Nov;71(11):6753-61 [16269706] Clin Microbiol Infect. 2006 Jul;12(7):634-41 [16774559] PLoS Negl Trop Dis. 2008;2(3):e196 [18335069] Appl Environ Microbiol. 2009 Mar;75(5):1373-80 [19139228] Foodborne Pathog Dis. 2009 Mar;6(2):207-15 [19099358] Water Res. 2010 Mar;44(6):1873-83 [19945729] Appl Environ Microbiol. 2010 Jun;76(11):3744-7 [20400570] Vet Rec. 2010 May 29;166(22):691-2 [20511653] J Vet Med Sci. 2010 May;72(5):589-97 [20103992] J Infect Dis. 2000 Jan;181(1):261-72 [10608775] Avian Dis. 2000 Jan-Mar;44(1):23-33 [10737641] Appl Environ Microbiol. 2000 Jun;66(6):2572-7 [10831440] Vet Microbiol. 2001 Feb 12;78(3):241-9 [11165068] Vet Microbiol. 2001 Oct 1;82(4):311-20 [11506925] Avian Dis. 2002 Apr-Jun;46(2):342-52 [12061643] J Clin Microbiol. 2003 Apr;41(4):1375-85 [12682117] Appl Environ Microbiol. 1992 Dec;58(12):3809-15 [1476425] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.00726-10 ER - TY - JOUR T1 - Pulmonary infections and risk of lung cancer among persons with AIDS. AN - 758835897; 20736841 AB - Lung cancer risk is significantly increased among persons with AIDS (PWA), and increased smoking may not explain all of the elevated risk, suggesting a role for additional cofactors. We investigated whether AIDS-defining pulmonary infections (recurrent pneumonia, Pneumocystis jirovecii pneumonia, and pulmonary tuberculosis) affected the risk of subsequent lung cancer over 10 years after AIDS onset among 322,675 PWA, whose records were linked with cancer registries in 11 US regions. We assessed lung cancer hazard ratios (HRs) using Cox regression and indirectly adjusted HRs for confounding by smoking. Individuals with recurrent pneumonia (n = 5317) were at significantly higher lung cancer risk than those without [HR = 1.63, 95% confidence interval (CI) = 1.08 to 2.46, adjusted for age, race, sex, HIV acquisition mode, CD4 count, and AIDS diagnosis year]. This association was especially strong among young PWA (<50 years HR = 1.99 vs. ≥50 years HR = 1.10) and was significantly elevated during 5-10 years after recurrent pneumonia diagnosis (HR = 2.41; 95% CI = 1.07 to 5.47). Although attenuated, HRs for recurrent pneumonia remained nonsignificantly elevated after indirect adjustment for smoking. Lung cancer risk was unrelated to tuberculosis [(n = 13,878) HR = 1.12, 95% CI = 0.82 to 1.53] or Pneumocystis jirovecii pneumonia [(n = 69,771) HR = 0.97, 95% CI = 0.80 to 1.18]. The increased lung cancer risk associated with recurrent pneumonia supports the hypothesis that chronic pulmonary inflammation arising from infections contributes to lung carcinogenesis. JF - Journal of acquired immune deficiency syndromes (1999) AU - Shebl, Fatma M AU - Engels, Eric A AU - Goedert, James J AU - Chaturvedi, Anil K AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 375 EP - 379 VL - 55 IS - 3 KW - Index Medicus KW - AIDS/HIV KW - United States KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Risk Assessment KW - Acquired Immunodeficiency Syndrome -- complications KW - AIDS-Related Opportunistic Infections -- complications KW - Lung Neoplasms -- epidemiology KW - Tuberculosis, Pulmonary -- complications KW - Pneumonia, Pneumocystis -- complications KW - Pneumonia, Bacterial -- complications KW - AIDS-Related Opportunistic Infections -- microbiology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758835897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Pulmonary+infections+and+risk+of+lung+cancer+among+persons+with+AIDS.&rft.au=Shebl%2C+Fatma+M%3BEngels%2C+Eric+A%3BGoedert%2C+James+J%3BChaturvedi%2C+Anil+K&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-11-01&rft.volume=55&rft.issue=3&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=1944-7884&rft_id=info:doi/10.1097%2FQAI.0b013e3181eef4f7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Intern Med. 2000 Mar 7;132(5):369-72 [10691587] Lung Cancer. 2010 Apr;68(1):20-6 [19545930] Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):612-6 [10934095] Int J Cancer. 2003 May 20;105(1):101-7 [12672038] Am J Epidemiol. 2004 Aug 15;160(4):384-92 [15286024] MMWR Morb Mortal Wkly Rep. 1993 Apr 30;42(16):308-10 [8474424] Am J Epidemiol. 1993 Dec 1;138(11):909-22 [8256779] Am J Epidemiol. 1995 Jun 1;141(11):1023-32 [7771438] N Engl J Med. 1995 Sep 28;333(13):845-51 [7651475] Am J Epidemiol. 1999 Jan 1;149(1):13-20 [9883789] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):773-8 [15824142] Arch Intern Med. 2005 Jul 11;165(13):1533-40 [16009870] J Clin Oncol. 2006 Mar 20;24(9):1383-8 [16549832] Lung Cancer. 2006 Jul;53(1):5-12 [16733074] AIDS. 2006 Aug 1;20(12):1645-54 [16868446] AIDS. 2007 Jan 11;21(2):207-13 [17197812] Arch Intern Med. 2007 Feb 26;167(4):335-42 [17325294] Clin Infect Dis. 2007 Jul 1;45(1):103-10 [17554710] Expert Rev Anticancer Ther. 2008 Apr;8(4):605-15 [18402527] Respirology. 2008 Jun;13(4):585-9 [18410259] Int J Cancer. 2009 Mar 1;124(5):1183-7 [19058197] Int J Cancer. 2009 Dec 15;125(12):2936-44 [19521963] Lancet Oncol. 2009 Dec;10(12):1152-9 [19818686] JAMA. 2000 Aug 9;284(6):706-12 [10927778] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/QAI.0b013e3181eef4f7 ER - TY - JOUR T1 - Ultrastructural analysis of ICP34.5- herpes simplex virus 1 replication in mouse brain cells in vivo. AN - 757177921; 20702618 AB - Replication-competent forms of herpes simplex virus 1 (HSV-1) defective in the viral neurovirulence factor infected cell protein 34.5 (ICP34.5) are under investigation for use in the therapeutic treatment of cancer. In mouse models, intratumoral injection of ICP34.5-defective oncolytic HSVs (oHSVs) has resulted in the infection and lysis of tumor cells, an associated decrease in tumor size, and increased survival times. The ability of these oHSVs to infect and lyse cells is frequently characterized as exclusive to or selective for tumor cells. However, the extent to which ICP34.5-deficient HSV-1 replicates in and may be neurotoxic to normal brain cell types in vivo is poorly understood. Here we report that HSV-1 defective in ICP34.5 expression is capable of establishing a productive infection in at least one normal mouse brain cell type. We show that γ34.5 deletion viruses replicate productively in and induce cellular damage in infected ependymal cells. Further evaluation of the effects of oHSVs on normal brain cells in animal models is needed to enhance our understanding of the risks associated with the use of current and future oHSVs in the brains of clinical trial subjects and to provide information that can be used to create improved oHSVs for future use. JF - Journal of virology AU - Mehta, Hina AU - Muller, Jacqueline AU - Markovitz, Nancy S AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2010/11// PY - 2010 DA - November 2010 SP - 10982 EP - 10990 VL - 84 IS - 21 KW - Viral Proteins KW - 0 KW - gamma 34.5 protein, Human herpesvirus 1 KW - Index Medicus KW - Virus Replication KW - Herpes Simplex KW - Animals KW - Oncolytic Viruses -- genetics KW - Oncolytic Virotherapy KW - Mice KW - Gene Deletion KW - Viral Proteins -- genetics KW - Herpesvirus 1, Human -- pathogenicity KW - Brain -- pathology KW - Defective Viruses -- pathogenicity KW - Brain -- virology KW - Defective Viruses -- ultrastructure KW - Herpesvirus 1, Human -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/757177921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Ultrastructural+analysis+of+ICP34.5-+herpes+simplex+virus+1+replication+in+mouse+brain+cells+in+vivo.&rft.au=Mehta%2C+Hina%3BMuller%2C+Jacqueline%3BMarkovitz%2C+Nancy+S&rft.aulast=Mehta&rft.aufirst=Hina&rft.date=2010-11-01&rft.volume=84&rft.issue=21&rft.spage=10982&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.00337-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Apr;74(8):3832-41 [10729157] Neuroscience. 2008 Sep 22;156(1):81-8 [18682279] J Virol. 2004 Jul;78(14):7653-66 [15220440] J Gen Virol. 1968 May;2(3):357-64 [4300104] Cell. 1981 May;24(2):555-65 [6263501] Cell. 1981 Jul;25(1):227-32 [6268303] Virology. 1989 Nov;173(1):276-83 [2554573] Science. 1990 Nov 30;250(4985):1262-6 [2173860] J Gen Virol. 1991 Mar;72 ( Pt 3):631-9 [1848598] J Clin Invest. 1993 Jun;91(6):2837-43 [8390490] Childs Nerv Syst. 1994 Apr;10(3):151-5 [8044808] J Gen Virol. 1994 Dec;75 ( Pt 12):3679-86 [7996163] Glia. 1995 May;14(1):1-13 [7615341] Nat Med. 1995 Sep;1(9):938-43 [7585221] Arch Virol. 1996;141(3-4):505-24 [8645092] Cancer Res. 1997 Apr 15;57(8):1502-9 [9108452] J Virol. 1997 Jul;71(7):5560-9 [9188630] Hum Gene Ther. 1997 Nov 20;8(17):2057-68 [9414254] J Gen Virol. 1998 Mar;79 ( Pt 3):525-36 [9519831] J Virol. 1998 Dec;72(12):9992-10002 [9811737] Cell. 1999 Jan 8;96(1):25-34 [9989494] J Virol. 1999 Oct;73(10):8010-8 [10482549] Brain Res Brain Res Rev. 2005 Apr;48(2):220-33 [15850661] Behav Brain Res. 2005 Sep 8;163(2):227-36 [15990178] J Virol. 2005 Oct;79(20):13047-59 [16189007] J Virol. 2006 Feb;80(3):1610-1; author reply 1611-2 [16415038] Mol Ther. 2006 May;13(5):891-8 [16574492] J Virol. 2006 Jul;80(13):6716-7; author replies 6717-9 [16775362] Cancer Gene Ther. 2006 Nov;13(11):975-92 [16604059] Expert Rev Neurother. 2007 Apr;7(4):321-4 [17425484] Cell Host Microbe. 2007 Mar 15;1(1):23-35 [18005679] Hum Vaccin. 2008 Mar-Apr;4(2):91-105 [18496918] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):190-5 [11756670] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JVI.00337-10 ER - TY - JOUR T1 - Challenges in assessing nanomaterial toxicology: a personal perspective. AN - 756663890; 20799267 AB - Nanotechnology exploits the fact that nanoparticles exhibit unique physicochemical properties, which are distinct from fine-sized particles of the same composition. It follows that nanoparticles may also express distinct bioactivity and unique interactions with biological systems. Therefore, it is essential to assess the potential health risks of exposure to nanoparticles to allow development and implementation of prevention measures. Risk assessment requires data concerning hazard and exposure. Several challenges face the field of nanotoxicology in obtaining the necessary data for assessment of the bioactivity of nanoparticles. They include: (1) the vast number of nanoparticle types to be evaluated, (2) the need to use nanoparticle doses and structure sizes in cellular and animal test systems which are relevant to anticipated workplace exposures, and (3) artifactual in vitro results due to absorption of nutrients or assay indicator compounds from the culture media. This 'opinion' reviews the progress made in the field of nanotoxicology in recent years to overcome these challenges. © 2010 John Wiley & Sons, Inc. JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology AU - Geraci, Charles L AU - Castranova, Vincent AD - Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. PY - 2010 SP - 569 EP - 577 VL - 2 IS - 6 KW - Index Medicus KW - Rats KW - Animals KW - Particle Size KW - Humans KW - Mice KW - Cell Line KW - Toxicity Tests -- methods KW - Nanoparticles -- ultrastructure KW - Toxicity Tests -- instrumentation KW - Risk Assessment -- methods KW - Nanoparticles -- toxicity KW - Nanoparticles -- administration & dosage KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756663890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.atitle=Challenges+in+assessing+nanomaterial+toxicology%3A+a+personal+perspective.&rft.au=Geraci%2C+Charles+L%3BCastranova%2C+Vincent&rft.aulast=Geraci&rft.aufirst=Charles&rft.date=2010-11-01&rft.volume=2&rft.issue=6&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.issn=1939-0041&rft_id=info:doi/10.1002%2Fwnan.108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-24 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/wnan.108 ER - TY - JOUR T1 - Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague-Dawley rats using liquid chromatography with tandem mass spectrometry. AN - 755404437; 20872634 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products, epoxy resin-based food can liners, and paper products. The presence of BPA in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure and is problematic because of the potential for endocrine disruption. The ubiquity of environmental BPA in common laboratory supplies used for sample collection, storage, and analysis greatly increases the likelihood of false positive determinations, particularly at trace levels. The current study validated using liquid chromatography/tandem mass spectrometry (LC/MS/MS) in conjunction with deuterated BPA as the dosing material to circumvent contamination for high sensitivity quantifications in rat serum, tissues, urine, and feces. The methods described provided measurements of both estrogen receptor-active aglycone and metabolically deactivated conjugated forms of BPA, a distinction that is critical to assessing toxicological potential. The adequacy of the described methodology was substantiated by its utility in analyzing samples from rats treated orally with a 100 µg/kg body weight dose of d6-BPA. These results emphasize the challenges inherent in measuring BPA in biological samples and how employing stable isotope labeled dosing can facilitate pharmacokinetic studies needed to understand BPA metabolism and disposition. Such studies conducted in experimental animal models, in conjunction with properly validated human biomonitoring data, will be the basis for PBPK modeling of BPA in environmentally exposed humans. Published in 2010 by John Wiley & Sons, Ltd. JF - Rapid communications in mass spectrometry : RCM AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Vanlandingham, Michelle AU - Doerge, Daniel R AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2010/10/30/ PY - 2010 DA - 2010 Oct 30 SP - 3011 EP - 3020 VL - 24 IS - 20 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - Deuterium KW - AR09D82C7G KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Clinical Laboratory Techniques -- standards KW - Reproducibility of Results KW - Reference Standards KW - Female KW - Chromatography, Liquid -- methods KW - Deuterium -- blood KW - Phenols -- blood KW - Tandem Mass Spectrometry -- methods KW - Phenols -- chemistry KW - Deuterium -- chemistry KW - Deuterium -- analysis KW - Phenols -- urine KW - Feces -- chemistry KW - Phenols -- analysis KW - Deuterium -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755404437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Quantification+of+deuterated+bisphenol+A+in+serum%2C+tissues%2C+and+excreta+from+adult+Sprague-Dawley+rats+using+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Twaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Anastos&rft.aufirst=Kathryn&rft.date=2010-10-20&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013525 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-30 N1 - Date created - 2010-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/rcm.4733 ER - TY - JOUR T1 - Toxicity assessment of pramipexole in juvenile rhesus monkeys AN - 759321279; 13783343 AB - Pramipexole (PPX) is a dopamine agonist approved for the treatment of the signs and symptoms of idiopathic Parkinson's disease as well as restless leg syndrome. The objective of this study was to investigate the toxicity of PPX when administered orally to juvenile rhesus monkeys once daily for 30 weeks, and to assess the reversibility of toxicity during a 12-week recovery. Rhesus monkeys (N=4 males and 4 females/group; 22-24 months of age) were orally treated daily for 30 weeks with 0.0, 0.1, 0.5 or 2.0mg/kg PPX, and subjects were assessed daily using the NCTR Operant Test Battery (OTB). Clinical chemistry, hematology, ophthalmology and other standard postmortem toxicological evaluations, including histopathology and neuropathology as well as toxicokinetics were performed. The systemic exposure to PPX was higher than that at therapeutic doses in man and AUC(0-24h)-data increased proportionally to dose. Blood pressure significantly decreased over time in all groups including control. Near the end of treatment, there were statistically significant decreases in heart rate for the 0.5 and 2.0mg/kg/day groups compared to control. After 4 weeks of dosing, serum prolactin was significantly decreased in all treatment groups compared to control. This decrease remained at the end of treatment in the 0.5 and 2.0mg/kg/day groups. In summary, administration of PPX at doses of up to 2.0mg/kg/day for 30 weeks to juvenile rhesus monkeys produced adverse findings which were attributable to its pharmacological properties, including hypoprolactinemia. JF - Toxicology AU - Patterson, Tucker A AU - Li, Mi AU - Hotchkiss, Charlotte E AU - Mauz, Annerose AU - Eddie, Malcolm AU - Greischel, Andreas AU - Stierstorfer, Birgit AU - Deschl, Ulrich AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA Y1 - 2010/10/29/ PY - 2010 DA - 2010 Oct 29 SP - 164 EP - 171 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 276 IS - 3 SN - 0300-483X, 0300-483X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Operant conditioning KW - blood pressure KW - Parkinson's disease KW - Heart rate KW - Statistical analysis KW - Histopathology KW - Toxicity KW - Blood pressure KW - Leg KW - Prolactin KW - Neurodegenerative diseases KW - Movement disorders KW - Dopamine KW - heart rate KW - pramipexole KW - Neurotoxicity KW - Macaca mulatta KW - Hematology KW - Neuropathology KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759321279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Toxicity+assessment+of+pramipexole+in+juvenile+rhesus+monkeys&rft.au=Patterson%2C+Tucker+A%3BLi%2C+Mi%3BHotchkiss%2C+Charlotte+E%3BMauz%2C+Annerose%3BEddie%2C+Malcolm%3BGreischel%2C+Andreas%3BStierstorfer%2C+Birgit%3BDeschl%2C+Ulrich%3BPaule%2C+Merle+G&rft.aulast=Patterson&rft.aufirst=Tucker&rft.date=2010-10-29&rft.volume=276&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2010.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 1 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Operant conditioning; Parkinson's disease; Heart rate; Statistical analysis; Blood pressure; Prolactin; Leg; Neurodegenerative diseases; Dopamine; Movement disorders; pramipexole; Neurotoxicity; Neuropathology; heart rate; blood pressure; Histopathology; Hematology; Toxicity; Macaca mulatta DO - http://dx.doi.org/10.1016/j.tox.2010.08.002 ER - TY - JOUR T1 - Declining incidence of imported malaria in the Netherlands, 2000-2007 AN - 853474522; 14025343 AB - To describe the epidemiology and trends of imported malaria in the Netherlands from 2000 through 2007. Based on national surveillance data regarding all reported infections of imported malaria, diagnosed 2000 through 2007, incidence and trends of imported malaria in the Netherlands were estimated. Travellers statistics were used to estimate incidence, and data on malaria chemoprophylaxis prescriptions were used to estimate the number of unprotected travellers. Importation of malaria to the Netherlands is declining even as more travellers visit malaria-endemic countries. On average, 82% were acquired in sub-Saharan Africa, and 75% were caused by Plasmodium falciparum. The overall incidence in imported falciparum malaria fell from 21.5 to 6.6/10,000 of unprotected travellers. The percentage of unprotected travellers rose from 47% to 52% of all travellers. The incidence of imported falciparum infections is greatest from Middle and West Africa, and decreased from 121.3 to 36.5/10,000 travellers. The import of malaria from this region by immigrants visiting friends and relatives (VFR) decreased from 138 infections in 2000, to 69 infections in 2007. The annual number of imported malaria shows a continuing declining trend, even with an increasing number of travellers visiting malaria endemic countries. VFR import less malaria than previously, and contribute largely to the declining incidence seen. The decline is not readily explained by increased use of chemoprophylaxis and may reflect a reduced risk of infection due to decreasing local malaria transmission as observed in some malaria endemic areas. Nevertheless, the increasing number of unprotected travellers remains worrisome. JF - Malaria Journal AU - van Rijckevorsel, Gini GC AU - Sonder, Gerard JB AU - Geskus, Ronald B AU - Wetsteyn, Jose CFM AU - Ligthelm, Robert J AU - Visser, Leo G AU - Keuter, Monique AU - van Genderen, Perry JJ AU - van den Hoek, Anneke AD - Public Health Service Amsterdam, Department of Infectious Diseases, Amsterdam, The Netherlands Y1 - 2010/10/28/ PY - 2010 DA - 2010 Oct 28 SP - 300 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 9 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Biological surveys KW - Parasites KW - Human diseases KW - Data processing KW - Statistics KW - Travellers KW - Immigrants KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Importation KW - Public health KW - Endemic species KW - Epidemiology KW - Africa KW - Netherlands KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853474522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Declining+incidence+of+imported+malaria+in+the+Netherlands%2C+2000-2007&rft.au=van+Rijckevorsel%2C+Gini+GC%3BSonder%2C+Gerard+JB%3BGeskus%2C+Ronald+B%3BWetsteyn%2C+Jose+CFM%3BLigthelm%2C+Robert+J%3BVisser%2C+Leo+G%3BKeuter%2C+Monique%3Bvan+Genderen%2C+Perry+JJ%3Bvan+den+Hoek%2C+Anneke&rft.aulast=van+Rijckevorsel&rft.aufirst=Gini&rft.date=2010-10-28&rft.volume=9&rft.issue=&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=1475-2875&rft_id=info:doi/10.1186%2F1475-2875-9-300 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Biological surveys; Parasites; Endemic species; Human diseases; Epidemiology; Malaria; Public health; Statistics; Data processing; Immigrants; Travellers; Importation; Infection; Plasmodium falciparum; Africa; Netherlands DO - http://dx.doi.org/10.1186/1475-2875-9-300 ER - TY - JOUR T1 - Serum cytokine concentrations, flavonol intake and colorectal adenoma recurrence in the Polyp Prevention Trial AN - 954609884; 14163750 AB - Background:Serum cytokine concentrations may reflect inflammatory processes occurring during the development of colorectal neoplasms. Flavonols, bioactive compounds found in plant-based foods and beverages, may inhibit colorectal neoplasms partly by attenuating inflammation. Methods:Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to investigate the association between serum concentrations of interleukin (IL)1 beta , 2, 8, 10, 12p70, granulocyte macrophage colony stimulating factor, interferon- gamma , and tumour necrosis factor- alpha , measured over time, flavonol intake, estimated from a flavonol database used in conjunction with a food frequency questionnaire, and adenoma recurrence in 872 participants from the intervention arm of the Polyp Prevention Trial. Results:Decreased IL-2 concentration during the trial increased the risk of any adenoma recurrence (4th vs 1st quartile, OR=1.68, 95% CI=1.13-2.49), whereas decreased IL-1 beta or IL-10 reduced the risk of advanced adenoma recurrence (OR=0.37, 95% CI=0.15-0.94; OR=0.39, 95% CI=0.15-0.98, respectively). Individuals with flavonol intake above the median (29.7mg per day) and decreased cytokine concentrations had the lowest risk of advanced adenoma recurrence. Conclusion:Overall, no consistent associations were observed between serum cytokine profile and colorectal adenoma recurrence; however, decreased cytokine concentrations during high flavonol consumption may indicate prevention of colorectal neoplasms. JF - British Journal of Cancer AU - Bobe, G AU - Murphy, G AU - Albert, P S AU - Sansbury, L B AU - Lanza, E AU - Schatzkin, A AU - Colburn, N H AU - Cross, A J AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Building 576, Room 101, 1050 Boyles Street, Frederick, MD 21702, USA Y1 - 2010/10/26/ PY - 2010 DA - 2010 Oct 26 SP - 1453 EP - 1461 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 9 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Risk Abstracts KW - Inventories KW - gamma -Interferon KW - Beverages KW - Interleukin 2 KW - Food KW - Interleukin 1 KW - Granulocyte-macrophage colony-stimulating factor KW - Colorectal cancer KW - Polyps KW - Flavonols KW - Food plants KW - Cancer KW - Interleukin 10 KW - Inflammation KW - Databases KW - intervention KW - Risk factors KW - prevention KW - Cytokines KW - bioactive compounds KW - Tumor necrosis factor- alpha KW - Adenoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954609884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Serum+cytokine+concentrations%2C+flavonol+intake+and+colorectal+adenoma+recurrence+in+the+Polyp+Prevention+Trial&rft.au=Bobe%2C+G%3BMurphy%2C+G%3BAlbert%2C+P+S%3BSansbury%2C+L+B%3BLanza%2C+E%3BSchatzkin%2C+A%3BColburn%2C+N+H%3BCross%2C+A+J&rft.aulast=Bobe&rft.aufirst=G&rft.date=2010-10-26&rft.volume=103&rft.issue=9&rft.spage=1453&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Inventories; Beverages; Interleukin 2; Food; Interleukin 1; Colorectal cancer; Granulocyte-macrophage colony-stimulating factor; Flavonols; Polyps; Food plants; Interleukin 10; Inflammation; Databases; Risk factors; Cytokines; Tumor necrosis factor- alpha; Adenoma; intervention; prevention; bioactive compounds; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605915 ER - TY - JOUR T1 - Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study AN - 876236317; 14087049 AB - Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both MC1R variants and host phenotypes with melanoma risk has been limited. Methods We included 815 CDKN2A mutation carriers (473 affected, and 342 unaffected, with melanoma) from 186 families from 15 centers in Europe, North America, and Australia who participated in the Melanoma Genetics Consortium. In this family-based study, we assessed the associations of the four most frequent MC1R variants (V60L, V92M, R151C, and R160W) and the number of variants (1, greater than or equal to 2 variants), alone or jointly with the host phenotypes (hair color, propensity to sunburn, and number of nevi), with melanoma risk in CDKN2A mutation carriers. These associations were estimated and tested using generalized estimating equations. All statistical tests were two-sided. Results Carrying any one of the four most frequent MC1R variants (V60L, V92M, R151C, R160W) in CDKN2A mutation carriers was associated with a statistically significantly increased risk for melanoma across all continents (1.24 10 super(-6) less than or equal to P less than or equal to .0007). A consistent pattern of increase in melanoma risk was also associated with increase in number of MC1R variants. The risk of melanoma associated with at least two MC1R variants was 2.6-fold higher than the risk associated with only one variant (odds ratio = 5.83 [95% confidence interval = 3.60 to 9.46] vs 2.25 [95% confidence interval = 1.44 to 3.52]; P sub(trend) = 1.86 10 super(-8)). The joint analysis of MC1R variants and host phenotypes showed statistically significant associations of melanoma risk, together with MC1R variants (.0001 less than or equal to P less than or equal to .04), hair color (.006 less than or equal to P less than or equal to .06), and number of nevi (6.9 10 super(-6) less than or equal to P less than or equal to .02). Conclusion Results show that MC1R variants, hair color, and number of nevi were jointly associated with melanoma risk in CDKN2A mutation carriers. This joint association may have important consequences for risk assessments in familial settings. JF - Journal of the National Cancer Institute AU - Demenais, F AU - Mohamdi, H AU - Chaudru, V AU - Goldstein, A M AU - Newton Bishop, JA AU - Bishop, D T AU - Kanetsky, P A AU - Hayward, N K AU - Gillanders, E AU - Elder, DE AU - Avril, M F AU - Azizi, E AU - van Belle, P AU - Bergman, W AU - Bianchi-Scarra, G AU - Bressac-de Paillerets, B AU - Calista, D AU - Carrera, C AU - Hansson, J AU - Harland, M AU - Hogg, D AU - Hoeiom, V AU - Holland, E A AU - Ingvar, C AU - Landi, M T AU - Lang, J M AU - Mackie, R M AU - Mann, G J AU - Ming, ME AU - Njauw, C J AU - Olsson, H AU - Palmer, J AU - Pastorino, L AU - Puig, S AU - Randerson-Moor, J AU - Stark, M AU - Tsao, H AU - Tucker, MA AU - van der Velden, P AU - Yang, X R AU - Gruis, N AD - Affiliations of authors: INSERM, U946, Fondation Jean-Dausset-CEPH, Paris, France (FD, HM, VC, BB-dP); Universite Paris Diderot, Paris 7, Institut Universitaire d'Hematologie, Paris, France (FD, HM); Fondation Jean Dausset-CEPH, Paris, France (FD, HM, VC); Universite d'Evry Val d'Essonne, Evry, France (VC); Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (AMG, MTL, MAT, XRY); Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James's University Hospital, Leeds, UK (JANB, DTB, MH, JR-M); Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology & Biostatistics, University of Pennsylvania, Philadelphia, PA (PAK); Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queens, florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr florence.demenais@inserm.fr Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 SP - 1568 EP - 1583 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 20 SN - 0027-8874, 0027-8874 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Pigmentation KW - cyclin-dependent kinase inhibitors KW - Mathematical models KW - Statistical analysis KW - Hair KW - alpha -Melanocyte-stimulating hormone KW - Melanoma KW - Color KW - Risk factors KW - Nevus KW - Mutation KW - X 24340:Cosmetics, Toiletries & Household Products KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/876236317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+MC1R+Variants+and+Host+Phenotypes+With+Melanoma+Risk+in+CDKN2A+Mutation+Carriers%3A+A+GenoMEL+Study&rft.au=Demenais%2C+F%3BMohamdi%2C+H%3BChaudru%2C+V%3BGoldstein%2C+A+M%3BNewton+Bishop%2C+JA%3BBishop%2C+D+T%3BKanetsky%2C+P+A%3BHayward%2C+N+K%3BGillanders%2C+E%3BElder%2C+DE%3BAvril%2C+M+F%3BAzizi%2C+E%3Bvan+Belle%2C+P%3BBergman%2C+W%3BBianchi-Scarra%2C+G%3BBressac-de+Paillerets%2C+B%3BCalista%2C+D%3BCarrera%2C+C%3BHansson%2C+J%3BHarland%2C+M%3BHogg%2C+D%3BHoeiom%2C+V%3BHolland%2C+E+A%3BIngvar%2C+C%3BLandi%2C+M+T%3BLang%2C+J+M%3BMackie%2C+R+M%3BMann%2C+G+J%3BMing%2C+ME%3BNjauw%2C+C+J%3BOlsson%2C+H%3BPalmer%2C+J%3BPastorino%2C+L%3BPuig%2C+S%3BRanderson-Moor%2C+J%3BStark%2C+M%3BTsao%2C+H%3BTucker%2C+MA%3Bvan+der+Velden%2C+P%3BYang%2C+X+R%3BGruis%2C+N&rft.aulast=Demenais&rft.aufirst=F&rft.date=2010-10-20&rft.volume=102&rft.issue=20&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq363 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pigmentation; cyclin-dependent kinase inhibitors; Mathematical models; Risk factors; Statistical analysis; Nevus; alpha -Melanocyte-stimulating hormone; Hair; Mutation; Color; Melanoma DO - http://dx.doi.org/10.1093/jnci/djq363 ER - TY - JOUR T1 - Risk Factors for Cervical Precancer and Cancer in HIV-Infected, HPV-Positive Rwandan Women AN - 1014099245; 13966204 AB - Although cervical cancer is an AIDS-defining condition, infection with human immunodeficiency virus (HIV) may only modestly increase the risk of cervical cancer. There is a paucity of information regarding factors that influence the natural history of human papillomavirus (HPV) in HIV-infected women. We examined factors associated with cervical intraepithelial neoplasia grade 3 or cancer (CIN3+) in Rwandan women infected with both HIV and HPV (HIV+/HPV+). In 2005, 710 HIV+ Rwandan women .25 years enrolled in an observational cohort study; 476 (67%) tested HPV+. Each woman provided sociodemographic data, CD4 count, a cervical cytology specimen and cervicovaginal lavage (CVL), which was tested for >40 HPV genotypes by MY09/MY11 PCR assay. Logistic regression models calculated odds ratios (OR) and 95% confidence intervals (CI) of associations of potential risk factors for CIN3+ among HIV+/HPV+ women. Of the 476 HIV+/HPV+ women 42 (8.8%) were diagnosed with CIN3+. Factors associated with CIN3+ included .7 (vs. 0-2) pregnancies, malarial infection in the previous six months (vs. never), and .7 (vs. 0-2) lifetime sexual partners. Compared to women infected by non-HPV16 carcinogenic HPV genotypes, HPV16 infection was positively associated and non-carcinogenic HPV infection was inversely associated with CIN3+. CD4 count was significantly associated with CIN3+ only in analyses of women with non-HPV16 carcinogenic HPV (OR=0.62 per 100 cells/mm3, CI=0.40-0.97). In this HIV+/HPV+ population, lower CD4 was significantly associated with CIN3+ only in women infected with carcinogenic non-HPV16. We found a trend for higher risk of CIN3+ in HIV+ women reporting recent malarial infection; this association should be investigated in a larger group of HIV+/HPV+ women. JF - PLoS ONE AU - Anastos, Kathryn AU - Hoover, Donald R AU - Burk, Robert D AU - Cajigas, Antonio AU - Shi, Qiuhu AU - Singh, Diljeet K AU - Cohen, Mardge H AU - Mutimura, Eugene AU - Sturgis, Charles AU - Banzhaf, William C AU - Castle, Philip E AD - National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America Y1 - 2010/10/20/ PY - 2010 DA - 2010 Oct 20 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 0 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Virology & AIDS Abstracts KW - Data processing KW - Nucleotide sequence KW - Cervical cancer KW - Women KW - Genotypes KW - Infection KW - Neoplasia KW - Risks KW - Pregnancy KW - Sexual partners KW - CD4 antigen KW - Human immunodeficiency virus KW - Human papillomavirus 16 KW - Risk factors KW - Regression analysis KW - DNA KW - Polymerase chain reaction KW - Cytology KW - Cervix KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1014099245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Risk+Factors+for+Cervical+Precancer+and+Cancer+in+HIV-Infected%2C+HPV-Positive+Rwandan+Women&rft.au=Anastos%2C+Kathryn%3BHoover%2C+Donald+R%3BBurk%2C+Robert+D%3BCajigas%2C+Antonio%3BShi%2C+Qiuhu%3BSingh%2C+Diljeet+K%3BCohen%2C+Mardge+H%3BMutimura%2C+Eugene%3BSturgis%2C+Charles%3BBanzhaf%2C+William+C%3BCastle%2C+Philip+E&rft.aulast=Anastos&rft.aufirst=Kathryn&rft.date=2010-10-20&rft.volume=5&rft.issue=0&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0013525 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Women; DNA; Cytology; Polymerase chain reaction; Genotypes; Risks; Pregnancy; Sexual partners; CD4 antigen; Data processing; Risk factors; Cervical cancer; Regression analysis; Cervix; Infection; Neoplasia; Human immunodeficiency virus; Human papillomavirus 16; Human papillomavirus DO - http://dx.doi.org/10.1371/journal.pone.0013525 ER - TY - JOUR T1 - Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies AN - 849482081; 14025550 AB - Accumulating evidence indicate that the degree of dispersion of nanoparticles has a strong influence on their biological activities. The aims of this study were to develop a simple and rapid method of nanoparticle dispersion using a natural lung surfactant and to evaluate the effect of dispersion status of SWCNT on cytotoxicity and fibrogenicity in vitro and in vivo. The natural lung surfactant Survanta registered was used to disperse single-walled carbon nanotubes (SWCNT) in a biological medium. At physiologically relevant concentrations, Survanta registered produced well dispersed SWCNT without causing a cytotoxic or fibrogenic effect. In vitro studies show that Survanta registered -dispersed SWCNT (SD-SWCNT) stimulated proliferation of lung epithelial cells at low doses (0.04-0.12 mu g/ml or 0.02-0.06 mu g/cm2 exposed surface area) but had a suppressive effect at high doses. Non-dispersed SWCNT (ND-SWCNT) did not exhibit these effects, suggesting the importance of dispersion status of SWCNT on bioactivities. Studies using cultured human lung fibroblasts show that SD-SWCNT stimulated collagen production of the cells. This result is supported by a similar observation using Acetone/sonication dispersed SWCNT (AD-SWCNT), suggesting that Survanta registered did not mask the bioactivity of SWCNT. Likewise, in vivo studies show that both SD-SWCNT and AD-SWCNT induced lung fibrosis in mice, whereas the dispersing agent Survanta registered alone or Survanta registered -dispersed control ultrafine carbon black had no effect. The results indicate that Survanta registered was effective in dispersing SWCNT in biological media without causing cytotoxic effects at the test concentrations used in this study. SD-SWCNT stimulated collagen production of lung fibroblasts in vitro and induced lung fibrosis in vivo. Similar results were observed with AD-SWCNT, supporting the conclusion that Survanta registered did not mask the bioactivities of SWCNT and thus can be used as an effective dispersing agent. Since excessive collagen production is a hallmark of lung fibrosis, the results of this study suggest that the in vitro model using lung fibroblasts may be an effective and rapid screening tool for prediction of the fibrogenic potential of SWCNT in vivo. JF - Particle and Fibre Toxicology AU - Wang, Liying AU - Castranova, Vincent AU - Mishra, Anurag AU - Chen, Bean AU - Mercer, Robert R AU - Schwegler-Berry, Diane AU - Rojanasakul, Yon AD - National Institute for Occupational Safety and Health, HELD/PPRB, Morgantown, WV 26505, USA Y1 - 2010/10/19/ PY - 2010 DA - 2010 Oct 19 SP - 31 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Epithelial cells KW - Fibrosis KW - Surface area KW - Toxicity KW - Sonication KW - Fibroblasts KW - Collagen KW - Cytotoxicity KW - Carbon KW - Lung KW - nanotubes KW - Acetone KW - Cell proliferation KW - nanoparticles KW - Surfactants KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849482081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Dispersion+of+single-walled+carbon+nanotubes+by+a+natural+lung+surfactant+for+pulmonary+in+vitro+and+in+vivo+toxicity+studies&rft.au=Wang%2C+Liying%3BCastranova%2C+Vincent%3BMishra%2C+Anurag%3BChen%2C+Bean%3BMercer%2C+Robert+R%3BSchwegler-Berry%2C+Diane%3BRojanasakul%2C+Yon&rft.aulast=Wang&rft.aufirst=Liying&rft.date=2010-10-19&rft.volume=7&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Fibrosis; Surface area; Toxicity; Collagen; Fibroblasts; Sonication; Cytotoxicity; Carbon; Lung; nanotubes; Acetone; Cell proliferation; Surfactants; nanoparticles DO - http://dx.doi.org/10.1186/1743-8977-7-31 ER - TY - JOUR T1 - Folotyn (pralatrexate injection) for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma: U.S. Food and Drug Administration drug approval summary. AN - 758836611; 20739433 AB - On September 24, 2009, the U.S. Food and Drug Administration granted accelerated approval for Folotyn (pralatrexate injection, Allos Therapeutics, Inc.) as a single agent for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL); it is the first drug approved for this indication. This review was based on study PDX-008, a phase II, single-arm, nonrandomized, open-label, international, multicenter trial, designed to evaluate the safety and efficacy of pralatrexate when administered concurrently with vitamin B(12) and folic acid supplementation in patients with relapsed or refractory PTCL. The overall response rate was 27% in 109 evaluable patients [95% confidence interval (CI), 19-36%]. Twelve percent of 109 evaluable patients (95% CI, 7-20%)] had a response duration of ≥14 weeks. Six of these 13 patients achieved a complete response, and one patient had complete response unconfirmed. The most common grade 3 and 4 toxicities were thrombocytopenia, mucositis, and neutropenia. This accelerated approval was based on a response rate that is reasonably likely to predict clinical benefit in this heavily pretreated patient population with this rare disease. The applicant has committed to conducting postmarketing clinical trials to assess clinical benefit. The recommended starting dose of pralatrexate in patients with relapsed or refractory PTCL is 30 mg/m(2) via intravenous push over 3 to 5 min weekly for 6 weeks followed by a one-week rest (one cycle). Intramuscular injection of 1 mg vitamin B(12) should be administered every 8 to 10 weeks along with 1.0 mg folic acid given orally once a day. ©2010 AACR. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Malik, Shakun M AU - Liu, Ke AU - Qiang, Xu AU - Sridhara, Rajeshwari AU - Tang, Shenghui AU - McGuinn, W David AU - Verbois, S Leigh AU - Marathe, Anshu AU - Williams, Gene M AU - Bullock, Julie AU - Tornoe, Christoffer AU - Lin, Sue Ching AU - Ocheltree, Terrance AU - Vialpando, Milinda AU - Kacuba, Alice AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. shakun.malik@fda.hhs Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 4921 EP - 4927 VL - 16 IS - 20 SN - 1078-0432, 1078-0432 KW - 10-propargyl-10-deazaaminopterin KW - 0 KW - Folic Acid Antagonists KW - Aminopterin KW - JYB41CTM2Q KW - Index Medicus KW - United States KW - Folic Acid Antagonists -- therapeutic use KW - United States Food and Drug Administration KW - Humans KW - Drug Approval KW - Folic Acid Antagonists -- adverse effects KW - Aged KW - Middle Aged KW - Folic Acid Antagonists -- chemistry KW - Male KW - Female KW - Aminopterin -- adverse effects KW - Lymphoma, T-Cell -- drug therapy KW - Aminopterin -- chemistry KW - Aminopterin -- therapeutic use KW - Aminopterin -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758836611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Quantification+of+deuterated+bisphenol+A+in+serum%2C+tissues%2C+and+excreta+from+adult+Sprague-Dawley+rats+using+liquid+chromatography+with+tandem+mass+spectrometry.&rft.au=Twaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BVanlandingham%2C+Michelle%3BDoerge%2C+Daniel+R&rft.aulast=Twaddle&rft.aufirst=Nathan&rft.date=2010-10-30&rft.volume=24&rft.issue=20&rft.spage=3011&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=1097-0231&rft_id=info:doi/10.1002%2Frcm.4733 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-14 N1 - Date created - 2010-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1078-0432.CCR-10-1214 ER - TY - JOUR T1 - Brain mu-opioid receptor binding predicts treatment outcome in cocaine-abusing outpatients. AN - 756660543; 20579973 AB - Cocaine users not seeking treatment have increased regional brain mu-opioid receptor (mOR) binding that correlates with cocaine craving and tendency to relapse. In cocaine-abusing outpatients in treatment, the relationship of mOR binding and treatment outcome is unknown. We determined whether regional brain mOR binding before treatment correlates with outcome and compared it with standard clinical predictors of outcome. Twenty-five individuals seeking outpatient treatment for cocaine abuse or dependence (DSM-IV) received up to 12 weeks of cognitive-behavioral therapy and cocaine abstinence reinforcement, whereby each cocaine-free urine was reinforced with vouchers redeemable for goods. Regional brain mOR binding was measured before treatment using positron emission tomography with [¹¹C]]-carfentanil (a selective mOR agonist). Main outcome measures were: 1) overall percentage of urines positive for cocaine during first month of treatment; and 2) longest duration (weeks) of abstinence from cocaine during treatment, all verified by urine toxicology. Elevated mOR binding in the medial frontal and middle frontal gyri before treatment correlated with greater cocaine use during treatment. Elevated mOR binding in the anterior cingulate, medial frontal, middle frontal, middle temporal, and sublobar insular gyri correlated with shorter duration of cocaine abstinence during treatment. Regional mOR binding contributed significant predictive power for treatment outcome beyond that of standard clinical variables such as baseline drug and alcohol use. Elevated mOR binding in brain regions associated with reward sensitivity is a significant independent predictor of treatment outcome in cocaine-abusing outpatients, suggesting a key role for the brain endogenous opioid system in cocaine addiction. Published by Elsevier Inc. JF - Biological psychiatry AU - Ghitza, Udi E AU - Preston, Kenzie L AU - Epstein, David H AU - Kuwabara, Hiroto AU - Endres, Christopher J AU - Bencherif, Badreddine AU - Boyd, Susan J AU - Copersino, Marc L AU - Frost, J James AU - Gorelick, David A AD - Intramural Research Program, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. ghitzau@nida.nih.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 697 EP - 703 VL - 68 IS - 8 KW - Receptors, Opioid, mu KW - 0 KW - Cocaine KW - I5Y540LHVR KW - carfentanil KW - LA9DTA2L8F KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Magnetic Resonance Imaging KW - Positron-Emission Tomography -- methods KW - Cocaine -- urine KW - Humans KW - Adult KW - Treatment Outcome KW - Fentanyl -- metabolism KW - Predictive Value of Tests KW - Radioligand Assay -- methods KW - Fentanyl -- analogs & derivatives KW - Male KW - Female KW - Cocaine-Related Disorders -- therapy KW - Brain -- metabolism KW - Receptors, Opioid, mu -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging KW - Cognitive Therapy -- methods KW - Cocaine-Related Disorders -- urine KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756660543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Brain+mu-opioid+receptor+binding+predicts+treatment+outcome+in+cocaine-abusing+outpatients.&rft.au=Ghitza%2C+Udi+E%3BPreston%2C+Kenzie+L%3BEpstein%2C+David+H%3BKuwabara%2C+Hiroto%3BEndres%2C+Christopher+J%3BBencherif%2C+Badreddine%3BBoyd%2C+Susan+J%3BCopersino%2C+Marc+L%3BFrost%2C+J+James%3BGorelick%2C+David+A&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2010-10-15&rft.volume=68&rft.issue=8&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=1873-2402&rft_id=info:doi/10.1016%2Fj.biopsych.2010.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-09 N1 - Date created - 2010-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2009 Jul;34(8):1946-57 [19279569] Trends Neurosci. 2009 Jan;32(1):56-67 [18986715] Psychopharmacology (Berl). 2008 Nov;200(4):475-86 [18762918] Neurosci Biobehav Rev. 2010 Nov;35(2):220-31 [20170672] Am J Psychiatry. 2000 Jan;157(1):127-9 [10618027] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Ann N Y Acad Sci. 2001 Jun;937:74-92 [11458541] J Neurosci. 2002 Jun 15;22(12):5100-7 [12077205] Drug Alcohol Depend. 2002 Sep 1;68(1):35-48 [12167551] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Nucl Med Biol. 2003 Feb;30(2):177-86 [12623117] Psychol Addict Behav. 2003 Mar;17(1):73-82 [12665084] Clin Pharmacol Ther. 2004 Jan;75(1):34-48 [14749690] Biol Psychiatry. 2004 Apr 1;55(7):759-65 [15039006] J Consult Clin Psychol. 1984 Oct;52(5):774-83 [6501663] J Comput Assist Tomogr. 1985 Mar-Apr;9(2):231-6 [2982931] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Pers Soc Psychol. 1986 Mar;50(3):571-9 [3701593] J Consult Clin Psychol. 1988 Oct;56(5):715-20 [3192787] J Comput Assist Tomogr. 1995 Sep-Oct;19(5):788-96 [7560327] Brain Res. 1995 Jun 5;682(1-2):245-50 [7552322] J Cereb Blood Flow Metab. 1996 Sep;16(5):834-40 [8784228] Nat Med. 1996 Nov;2(11):1225-9 [8898749] IEEE Trans Med Imaging. 1997 Apr;16(2):187-98 [9101328] Am J Psychiatry. 1999 Jun;156(6):842-8 [10360121] Eur Neuropsychopharmacol. 2005 May;15(3):297-303 [15820419] J Neurosci. 2005 May 4;25(18):4512-20 [15872098] Biol Psychiatry. 2005 Jun 15;57(12):1573-82 [15953495] Arch Gen Psychiatry. 2005 Jul;62(7):761-8 [15997017] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Am J Addict. 2006 Nov-Dec;15(6):434-9 [17182445] Science. 2007 Jan 26;315(5811):531-4 [17255515] Am J Drug Alcohol Abuse. 2007;33(2):191-206 [17497542] Biol Psychiatry. 2007 Jun 1;61(11):1252-9 [16945342] Cochrane Database Syst Rev. 2007;(3):CD003023 [17636713] Am J Psychiatry. 2008 Nov;165(11):1442-8 [18765480] Comment In: Biol Psychiatry. 2010 Oct 15;68(8):685-6 [20888455] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.biopsych.2010.05.003 ER - TY - JOUR T1 - Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. AN - 749010896; 20099276 AB - Cancer cells that develop resistance to chemotherapeutic agents are a major clinical obstacle in the successful treatment of breast cancer. Acquired cancer chemoresistance is a multifactorial phenomenon, involving various mechanisms and processes. Recent studies suggest that chemoresistance may be linked to drug-induced dysregulation of microRNA function. Furthermore, mounting evidence indicates the existence of similarities between drug-resistant and metastatic cancer cells in terms of resistance to apoptosis and enhanced invasiveness. We studied the role of miRNA alterations in the acquisition of cisplatin-resistant phenotype in MCF-7 human breast adenocarcinoma cells. We identified a total of 103 miRNAs that were overexpressed or underexpressed (46 upregulated and 57 downregulated) in MCF-7 cells resistant to cisplatin. These differentially expressed miRNAs are involved in the control of cell signaling, cell survival, DNA methylation and invasiveness. The most significantly dysregulated miRNAs were miR-146a, miR-10a, miR-221/222, miR-345, miR-200b and miR-200c. Furthermore, we demonstrated that miR-345 and miR-7 target the human multidrug resistance-associated protein 1. These results suggest that dysregulated miRNA expression may underlie the abnormal functioning of critical cellular processes associated with the cisplatin-resistant phenotype. JF - International journal of cancer AU - Pogribny, Igor P AU - Filkowski, Jody N AU - Tryndyak, Volodymyr P AU - Golubov, Andrey AU - Shpyleva, Svitlana I AU - Kovalchuk, Olga AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 1785 EP - 1794 VL - 127 IS - 8 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - MicroRNAs KW - Multidrug Resistance-Associated Proteins KW - RNA, Messenger KW - Luciferases KW - EC 1.13.12.- KW - Cisplatin KW - Q20Q21Q62J KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Luciferases -- metabolism KW - RNA, Messenger -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Multidrug Resistance-Associated Proteins -- genetics KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Female KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Cisplatin -- pharmacology KW - Drug Resistance, Neoplasm KW - MicroRNAs -- physiology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749010896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Alterations+of+microRNAs+and+their+targets+are+associated+with+acquired+resistance+of+MCF-7+breast+cancer+cells+to+cisplatin.&rft.au=Pogribny%2C+Igor+P%3BFilkowski%2C+Jody+N%3BTryndyak%2C+Volodymyr+P%3BGolubov%2C+Andrey%3BShpyleva%2C+Svitlana+I%3BKovalchuk%2C+Olga&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-15&rft.volume=127&rft.issue=8&rft.spage=1785&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25191 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-23 N1 - Date created - 2010-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25191 ER - TY - JOUR T1 - Evaluating the use of fatty acid profiles to identify deep-sea Vibrio isolates AN - 745936282; 13139866 AB - Capillary gas chromatography with flame ionisation detection (GC-FID) was used to determine the cellular fatty acid (CFA) profiles of a number of Vibrio strains obtained from ATCC and grown on various media. This initial determination for optimal growth conditions, including type of medium and incubation temperature, for these various ATCC Vibrio species, was important for use in the subsequent evaluation of deep-sea Vibrio strains. The deep-sea Vibrios were obtained from Harbor Branch Oceanographic Institution (Fort Pierce, FL), and GC-FID analysis was used to determine whole cell fatty acid methyl esters (FAMEs) from the cells. The Vibrio strains were cultured for 24 h on a specific medium which included brain heart infusion (BHI) agar, trypticase soy agar (TSA), trypticase soy broth agar (TSBA), and Luria-Bertani (LB) agar. The temperature of incubation was 28 C for cells grown on TSA, TSBA, and LB and 35 C for BHI. A data set for each Vibrio species was prepared, using fatty acid profiles for a specific medium. Major fatty acids of the Vibrio strains evaluated in this study were straight-chain C sub(12:0), C sub(14:0), C sub(16:0), and unsaturated summed C sub(16:1) Omega 7c/C sub(16:1) Omega 6c, C sub(18:1) Omega 7c, and summed C sub(14:0) 3-OH/iso-C sub(16:1). Most of the deep-sea Vibrio isolates were identified as Vibrio parahaemolyticus and Vibrio harveyi. Analysis of FAMEs from Vibro strains grown on a specific medium by this rapid GC-FID method can provide a sensitive procedure for the identification of these organisms, and the differentiation between Vibrio species. JF - Food Chemistry AU - Hoffmann, Maria AU - Fischer, Markus AU - Whittaker, Paul AD - Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740-3835, United States, paul.whittaker@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 943 EP - 950 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 122 IS - 4 SN - 0308-8146, 0308-8146 KW - ASFA Marine Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Agar KW - ASW, USA, Florida, Fort Pierce KW - Growth conditions KW - Chromatographic techniques KW - Vibrio harveyi KW - Differentiation KW - Gas chromatography KW - Vibrio parahaemolyticus KW - fatty acid methyl esters KW - Disease detection KW - Circulatory system KW - Temperature effects KW - Heart KW - Data processing KW - Brain KW - Strains KW - Harbours KW - Soybeans KW - Vibrio KW - Fatty acids KW - Q1 08626:Food technology KW - Q4 27760:Microorganisms KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745936282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Evaluating+the+use+of+fatty+acid+profiles+to+identify+deep-sea+Vibrio+isolates&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BWhittaker%2C+Paul&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-10-15&rft.volume=122&rft.issue=4&rft.spage=943&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2010.04.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Heart; Agar; Chromatographic techniques; Brain; Fatty acids; Disease detection; Strains; Harbours; Circulatory system; Temperature effects; Differentiation; Data processing; Gas chromatography; Growth conditions; fatty acid methyl esters; Soybeans; Vibrio; Vibrio parahaemolyticus; Vibrio harveyi; ASW, USA, Florida, Fort Pierce DO - http://dx.doi.org/10.1016/j.foodchem.2010.04.015 ER - TY - JOUR T1 - Covariate adjusted weighted normal spatial scan statistics with applications to study geographic clustering of obesity and lung cancer mortality in the United States AN - 1017971515; 16691203 AB - In the field of cluster detection, a weighted normal model-based scan statistic was recently developed to analyze regional continuous data and to evaluate the clustering pattern of pre-defined cells (such as state, county, tract, school, hospital) that include many individuals. The continuous measures of interest are, for example, the survival rate, mortality rate, length of physical activity, or the obesity measure, namely, body mass index, at the cell level with an uncertainty measure for each cell. In this paper, we extend the method to search for clusters of the cells after adjusting for single/multiple categorical/continuous covariates. We apply the proposed method to 1999-2003 obesity data in the United States (US) collected by CDC's Behavioral Risk Factor Surveillance System with adjustment for age and race, and to 1999-2003 lung cancer age-adjusted mortality data by gender in the United States from the Surveillance Epidemiology and End Results (SEER Program) with adjustment for smoking and income. JF - Statistics in Medicine AU - Huang, Lan AU - Tiwari, Ram C AU - Pickle, Linda W AU - Zou, Zhaohui AD - Office of Biostatistics, CDER, FDA, Silver Spring, MD 20993, U.S.A., lan.huang@fda.hhs.gov Y1 - 2010/10/15/ PY - 2010 DA - 2010 Oct 15 SP - 2410 EP - 2422 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 23 SN - 1097-0258, 1097-0258 KW - Risk Abstracts KW - Cancer KW - Hospitals KW - Lung cancer KW - Mortality KW - Risk factors KW - income KW - obesity KW - schools KW - survival KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017971515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistics+in+Medicine&rft.atitle=Covariate+adjusted+weighted+normal+spatial+scan+statistics+with+applications+to+study+geographic+clustering+of+obesity+and+lung+cancer+mortality+in+the+United+States&rft.au=Huang%2C+Lan%3BTiwari%2C+Ram+C%3BPickle%2C+Linda+W%3BZou%2C+Zhaohui&rft.aulast=Huang&rft.aufirst=Lan&rft.date=2010-10-15&rft.volume=29&rft.issue=23&rft.spage=2410&rft.isbn=&rft.btitle=&rft.title=Statistics+in+Medicine&rft.issn=10970258&rft_id=info:doi/10.1002%2Fsim.3990 L2 - http://onlinelibrary.wiley.com/doi/10.1002/sim.3990/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-06-01 N1 - SubjectsTermNotLitGenreText - Mortality; schools; income; Risk factors; obesity; survival; Cancer; Hospitals; Lung cancer; USA DO - http://dx.doi.org/10.1002/sim.3990 ER - TY - JOUR T1 - Multiplexed, rapid detection of H5N1 using a PCR-free nanoparticle-based genomic microarray assay AN - 849476646; 14024108 AB - For more than a decade there has been increasing interest in the use of nanotechnology and microarray platforms for diagnostic applications. In this report, we describe a rapid and simple gold nanoparticle (NP)-based genomic microarray assay for specific identification of avian influenza virus H5N1 and its discrimination from other major influenza A virus strains (H1N1, H3N2). Capture and intermediate oligonucleotides were designed based on the consensus sequences of the matrix (M) gene of H1N1, H3N2 and H5N1 viruses, and sequences specific for the hemaglutinin (HA) and neuraminidase (NA) genes of the H5N1 virus. Viral RNA was detected within 2.5 hours using capture-target-intermediate oligonucleotide hybridization and gold NP-mediated silver staining in the absence of RNA fragmentation, target amplification, and enzymatic reactions. The lower limit of detection (LOD) of the assay was less than 100 fM for purified PCR fragments and 103 TCID50 units for H5N1 viral RNA. The NP-based microarray assay was able to detect and distinguish H5N1 sequences from those of major influenza A viruses (H1N1, H3N2). The new method described here may be useful for simultaneous detection and subtyping of major influenza A viruses. JF - BMC Biotechnology AU - Zhao, Jiangqin AU - Tang, Shixing AU - Storhoff, James AU - Marla, Sudhakar AU - Bao, Y Paul AU - Wang, Xue AU - Wong, Eric Y AU - Ragupathy, Viswanath AU - Ye, Zhiping AU - Hewlett, Indira K AD - Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 SP - 74 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Avian influenza virus KW - Influenza A KW - RNA viruses KW - double prime M gene KW - Oligonucleotides KW - Fowl plague KW - RNA KW - Influenza A virus KW - Gold KW - Polymerase chain reaction KW - genomics KW - Exo- alpha -sialidase KW - nanoparticles KW - nanotechnology KW - G 07880:Human Genetics KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849476646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biotechnology&rft.atitle=Multiplexed%2C+rapid+detection+of+H5N1+using+a+PCR-free+nanoparticle-based+genomic+microarray+assay&rft.au=Zhao%2C+Jiangqin%3BTang%2C+Shixing%3BStorhoff%2C+James%3BMarla%2C+Sudhakar%3BBao%2C+Y+Paul%3BWang%2C+Xue%3BWong%2C+Eric+Y%3BRagupathy%2C+Viswanath%3BYe%2C+Zhiping%3BHewlett%2C+Indira+K&rft.aulast=Zhao&rft.aufirst=Jiangqin&rft.date=2010-10-13&rft.volume=10&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=BMC+Biotechnology&rft.issn=1472-6750&rft_id=info:doi/10.1186%2F1472-6750-10-74 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Fowl plague; RNA; Influenza A; Polymerase chain reaction; Gold; RNA viruses; Exo- alpha -sialidase; genomics; double prime M gene; nanoparticles; Oligonucleotides; nanotechnology; Avian influenza virus; Influenza A virus DO - http://dx.doi.org/10.1186/1472-6750-10-74 ER - TY - JOUR T1 - An acute dose of gamma-hydroxybutyric acid alters gene expression in multiple mouse brain regions. AN - 754013625; 20654702 AB - Gamma-hydroxybutyric acid (GHB) is normally found in the brain in low concentrations and may function as a neurotransmitter, although the mechanism of action has not been completely elucidated. GHB has been used as a general anesthetic and is currently used to treat narcolepsy and alcoholism. Recreational use of GHB is primarily as a "club drug" and a "date rape drug," due to its amnesic effects. For this study, the hypothesis was that behavioral and neurochemical alterations may parallel gene expression changes in the brain after GHB administration. Adult male C57/B6N mice (n=5/group) were administered a single dose of 500 mg/kg GHB (i.p.) and were sacrificed 1, 2 and 4 h after treatment. Control mice were administered saline. Brains were removed and regionally dissected on ice. Total RNA from the hippocampus, cortex and striatum was extracted, amplified and labeled. Gene expression was evaluated using Agilent whole mouse genome 4x44K oligonucleotide microarrays. Microarray data were analyzed by ArrayTrack and differentially expressed genes (DEGs) were identified using P or = 1.7 as the criteria for significance. Principal component analysis (PCA) and Hierarchical Cluster Analysis (HCA) showed that samples from each time point clustered into distinct treatment groups with respect to sacrifice time. Ingenuity pathways analysis (IPA) was used to identify involved pathways. The results show that GHB induces gene expression alterations in hundreds of genes in the hippocampus, cortex and striatum, and the number of affected genes increases throughout a 4-h time course. Many of these DEGs are involved in neurological disease, apoptosis, and oxidative stress. Published by Elsevier Ltd. JF - Neuroscience AU - Schnackenberg, B J AU - Saini, U T AU - Robinson, B L AU - Ali, S F AU - Patterson, T A AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Bradley.Schnackenberg@fda.hhs.gov Y1 - 2010/10/13/ PY - 2010 DA - 2010 Oct 13 SP - 523 EP - 541 VL - 170 IS - 2 KW - Hydroxybutyrates KW - 0 KW - 4-hydroxybutyric acid KW - 30IW36W5B2 KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Sleep -- drug effects KW - Mice, Inbred C57BL KW - Dopamine -- metabolism KW - Mice KW - Serotonin -- metabolism KW - Time Factors KW - Male KW - Gene Expression -- drug effects KW - Brain -- drug effects KW - Hydroxybutyrates -- pharmacology KW - Microarray Analysis -- methods KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754013625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Multiple+Antigen+Peptide+Vaccines+against+Plasmodium+falciparum+Malaria&rft.au=Mahajan%2C+Babita%3BBerzofsky%2C+Jay+A%3BBoykins%2C+Robert+A%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BChattopadhyay%2C+Rana%3Bla+Vega%2C+Patricia+de%3BMoch%2C+JKathleen%3BHaynes%2C+JDavid%3BBelyakov%2C+Igor+M&rft.aulast=Mahajan&rft.aufirst=Babita&rft.date=2010-11-01&rft.volume=78&rft.issue=11&rft.spage=4613&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.00533-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2010.06.049 ER - TY - JOUR T1 - Two new ArrayTrack libraries for personalized biomedical research AN - 954603048; 14323801 AB - Recent advances in high-throughput genotyping technology are paving the way for research in personalized medicine and nutrition. However, most of the genetic markers identified from association studies account for a small contribution to the total risk/benefit of the studied phenotypic trait. Testing whether the candidate genes identified by association studies are causal is critically important to the development of personalized medicine and nutrition. An efficient data mining strategy and a set of sophisticated tools are necessary to help better understand and utilize the findings from genetic association studies. SNP (single nucleotide polymorphism) and QTL (quantitative trait locus) libraries were constructed and incorporated into ArrayTrack, with user-friendly interfaces and powerful search features. Data from several public repositories were collected in the SNP and QTL libraries and connected to other domain libraries (genes, proteins, metabolites, and pathways) in ArrayTrack. Linking the data sets within ArrayTrack allows searching of SNP and QTL data as well as their relationships to other biological molecules. The SNP library includes approximately 15 million human SNPs and their annotations, while the QTL library contains publically available QTLs identified in mouse, rat, and human. The QTL library was developed for finding the overlap between the map position of a candidate or metabolic gene and QTLs from these species. Two use cases were included to demonstrate the utility of these tools. The SNP and QTL libraries are freely available to the public through ArrayTrack at http://www.fda.gov/ArrayTrack. These libraries developed in ArrayTrack contain comprehensive information on SNPs and QTLs and are further cross-linked to other libraries. Connecting domain specific knowledge is a cornerstone of systems biology strategies and allows for a better understanding of the genetic and biological context of the findings from genetic association studies. JF - BMC Bioinformatics AU - Xu, Joshua AU - Wise, Carolyn AU - Varma, Vijayalakshmi AU - Fang, Hong AU - Ning, Baitang AU - Hong, Huixiao AU - Tong, Weida AU - Kaput, Jim AD - Z-Tech Corporation, an ICF International company at NCTR, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S6 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Biotechnology and Bioengineering Abstracts KW - Quantitative trait loci KW - Data processing KW - Single-nucleotide polymorphism KW - Genotyping KW - Genetic markers KW - Metabolites KW - Bioinformatics KW - Nutrition KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Two+new+ArrayTrack+libraries+for+personalized+biomedical+research&rft.au=Xu%2C+Joshua%3BWise%2C+Carolyn%3BVarma%2C+Vijayalakshmi%3BFang%2C+Hong%3BNing%2C+Baitang%3BHong%2C+Huixiao%3BTong%2C+Weida%3BKaput%2C+Jim&rft.aulast=Xu&rft.aufirst=Joshua&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S6&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Quantitative trait loci; Data processing; Single-nucleotide polymorphism; Genotyping; Genetic markers; Metabolites; Bioinformatics; Nutrition DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S6 ER - TY - JOUR T1 - The EDKB: an established knowledge base for endocrine disrupting chemicals AN - 954603044; 14323800 AB - Endocrine disruptors (EDs) and their broad range of potential adverse effects in humans and other animals have been a concern for nearly two decades. Many putative EDs are widely used in commercial products regulated by the Food and Drug Administration (FDA) such as food packaging materials, ingredients of cosmetics, medical and dental devices, and drugs. The Endocrine Disruptor Knowledge Base (EDKB) project was initiated in the mid 1990's by the FDA as a resource for the study of EDs. The EDKB database, a component of the project, contains data across multiple assay types for chemicals across a broad structural diversity. This paper demonstrates the utility of EDKB database, an integral part of the EDKB project, for understanding and prioritizing EDs for testing. The EDKB database currently contains 3,257 records of over 1,800 EDs from different assays including estrogen receptor binding, androgen receptor binding, uterotropic activity, cell proliferation, and reporter gene assays. Information for each compound such as chemical structure, assay type, potency, etc. is organized to enable efficient searching. A user-friendly interface provides rapid navigation, Boolean searches on EDs, and both spreadsheet and graphical displays for viewing results. The search engine implemented in the EDKB database enables searching by one or more of the following fields: chemical structure (including exact search and similarity search), name, molecular formula, CAS registration number, experiment source, molecular weight, etc. The data can be cross-linked to other publicly available and related databases including TOXNET, Cactus, ChemIDplus, ChemACX, Chem Finder, and NCI DTP. The EDKB database enables scientists and regulatory reviewers to quickly access ED data from multiple assays for specific or similar compounds. The data have been used to categorize chemicals according to potential risks for endocrine activity, thus providing a basis for prioritizing chemicals for more definitive but expensive testing. The EDKB database is publicly available and can be found online at http://edkb.fda.gov/webstart/edkb/index.html. Disclaimer:The views presented in this article do not necessarily reflect those of the US Food and Drug Administration. JF - BMC Bioinformatics AU - Ding, Don AU - Xu, Lei AU - Fang, Hong AU - Hong, Huixiao AU - Perkins, Roger AU - Harris, Steve AU - Bearden, Edward D AU - Shi, Leming AU - Tong, Weida AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S5 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Endocrine disruptors KW - Computer graphics KW - Cosmetics KW - Packaging materials KW - Androgen receptors KW - Databases KW - Reporter gene KW - Molecular weight KW - Bioinformatics KW - Cell proliferation KW - Estrogen receptors KW - Internet KW - Side effects KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954603044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=The+EDKB%3A+an+established+knowledge+base+for+endocrine+disrupting+chemicals&rft.au=Ding%2C+Don%3BXu%2C+Lei%3BFang%2C+Hong%3BHong%2C+Huixiao%3BPerkins%2C+Roger%3BHarris%2C+Steve%3BBearden%2C+Edward+D%3BShi%2C+Leming%3BTong%2C+Weida&rft.aulast=Ding&rft.aufirst=Don&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S5&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Endocrine disruptors; Computer graphics; Cosmetics; Packaging materials; Androgen receptors; Databases; Reporter gene; Molecular weight; Bioinformatics; Cell proliferation; Estrogen receptors; Side effects; Internet DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S5 ER - TY - JOUR T1 - An FDA bioinformatics tool for microbial genomics research on molecular characterization of bacterial foodborne pathogens using microarrays AN - 918045735; 14323799 AB - Advances in microbial genomics and bioinformatics are offering greater insights into the emergence and spread of foodborne pathogens in outbreak scenarios. The Food and Drug Administration (FDA) has developed a genomics tool, ArrayTrackTM, which provides extensive functionalities to manage, analyze, and interpret genomic data for mammalian species. ArrayTrackTM has been widely adopted by the research community and used for pharmacogenomics data review in the FDA's Voluntary Genomics Data Submission program. ArrayTrackTM has been extended to manage and analyze genomics data from bacterial pathogens of human, animal, and food origin. It was populated with bioinformatics data from public databases such as NCBI, Swiss-Prot, KEGG Pathway, and Gene Ontology to facilitate pathogen detection and characterization. ArrayTrackTM's data processing and visualization tools were enhanced with analysis capabilities designed specifically for microbial genomics including flag-based hierarchical clustering analysis (HCA), flag concordance heat maps, and mixed scatter plots. These specific functionalities were evaluated on data generated from a custom Affymetrix array (FDA-ECSG) previously developed within the FDA. The FDA-ECSG array represents 32 complete genomes of Escherichia coli and Shigella. The new functions were also used to analyze microarray data focusing on antimicrobial resistance genes from Salmonella isolates in a poultry production environment using a universal antimicrobial resistance microarray developed by the United States Department of Agriculture (USDA). The application of ArrayTrackTM to different microarray platforms demonstrates its utility in microbial genomics research, and thus will improve the capabilities of the FDA to rapidly identify foodborne bacteria and their genetic traits (e.g., antimicrobial resistance, virulence, etc.) during outbreak investigations. ArrayTrackTM is free to use and available to public, private, and academic researchers at http://www.fda.gov/ArrayTrack. JF - BMC Bioinformatics AU - Fang, Hong AU - Xu, Joshua AU - Ding, Don AU - Jackson, Scott A AU - Patel, Isha R AU - Frye, Jonathan G AU - Zou, Wen AU - Nayak, Rajesh AU - Foley, Steven AU - Chen, James AU - Su, Zhenqiang AU - Ye, Yanbin AU - Turner, Steve AU - Harris, Steve AU - Zhou, Guangxu AU - Cerniglia, Carl AU - Tong, Weida AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S4 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Agriculture KW - Genomes KW - Poultry KW - Drug resistance KW - Anadromous species KW - DNA microarrays KW - Disease transmission KW - Virulence KW - Computer programs KW - Escherichia coli KW - genomics KW - Drugs KW - Data processing KW - pharmacogenomics KW - Shigella KW - Pathogens KW - Databases KW - USA KW - Heat KW - Reviews KW - Bioinformatics KW - Salmonella KW - Gene mapping KW - J 02310:Genetics & Taxonomy KW - Q1 08484:Species interactions: parasites and diseases KW - A 01330:Food Microbiology KW - Q5 08524:Public health, medicines, dangerous organisms KW - G 07770:Bacteria KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918045735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=An+FDA+bioinformatics+tool+for+microbial+genomics+research+on+molecular+characterization+of+bacterial+foodborne+pathogens+using+microarrays&rft.au=Fang%2C+Hong%3BXu%2C+Joshua%3BDing%2C+Don%3BJackson%2C+Scott+A%3BPatel%2C+Isha+R%3BFrye%2C+Jonathan+G%3BZou%2C+Wen%3BNayak%2C+Rajesh%3BFoley%2C+Steven%3BChen%2C+James%3BSu%2C+Zhenqiang%3BYe%2C+Yanbin%3BTurner%2C+Steve%3BHarris%2C+Steve%3BZhou%2C+Guangxu%3BCerniglia%2C+Carl%3BTong%2C+Weida&rft.aulast=Fang&rft.aufirst=Hong&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Data processing; Anadromous species; Pathogens; Drugs; Disease transmission; Agriculture; Poultry; pharmacogenomics; Drug resistance; DNA microarrays; Computer programs; Databases; Heat; Reviews; genomics; Bioinformatics; Gene mapping; Escherichia coli; Shigella; Salmonella; USA DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S4 ER - TY - JOUR T1 - Evaluation of gene expression data generated from expired Affymetrix GeneChip registered microarrays using MAQC reference RNA samples AN - 874180396; 14323777 AB - The Affymetrix GeneChip registered system is a commonly used platform for microarray analysis but the technology is inherently expensive. Unfortunately, changes in experimental planning and execution, such as the unavailability of previously anticipated samples or a shift in research focus, may render significant numbers of pre-purchased GeneChip registered microarrays unprocessed before their manufacturer's expiration dates. Researchers and microarray core facilities wonder whether expired microarrays are still useful for gene expression analysis. In addition, it was not clear whether the two human reference RNA samples established by the MAQC project in 2005 still maintained their transcriptome integrity over a period of four years. Experiments were conducted to answer these questions. Microarray data were generated in 2009 in three replicates for each of the two MAQC samples with either expired Affymetrix U133A or unexpired U133Plus2 microarrays. These results were compared with data obtained in 2005 on the U133Plus2 microarray. The percentage of overlap between the lists of differentially expressed genes (DEGs) from U133Plus2 microarray data generated in 2009 and in 2005 was 97.44%. While there was some degree of fold change compression in the expired U133A microarrays, the percentage of overlap between the lists of DEGs from the expired and unexpired microarrays was as high as 96.99%. Moreover, the microarray data generated using the expired U133A microarrays in 2009 were highly concordant with microarray and TaqMan registered data generated by the MAQC project in 2005. Our results demonstrated that microarray data generated using U133A microarrays, which were more than four years past the manufacturer's expiration date, were highly specific and consistent with those from unexpired microarrays in identifying DEGs despite some appreciable fold change compression and decrease in sensitivity. Our data also suggested that the MAQC reference RNA samples, stored at -80 degree C, were stable over a time frame of at least four years. JF - BMC Bioinformatics AU - Wen, Zhining AU - Wang, Charles AU - Shi, Quan AU - Huang, Ying AU - Su, Zhenqiang AU - Hong, Huixiao AU - Tong, Weida AU - Shi, Leming AD - Division of Systems Biology, National Center for Toxicological Research (NCTR), US Food and Drug Administration (FDA), 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - S10 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 6 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Data processing KW - RNA KW - Bioinformatics KW - DNA microarrays KW - Compression KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/874180396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Evaluation+of+gene+expression+data+generated+from+expired+Affymetrix+GeneChip+registered+microarrays+using+MAQC+reference+RNA+samples&rft.au=Wen%2C+Zhining%3BWang%2C+Charles%3BShi%2C+Quan%3BHuang%2C+Ying%3BSu%2C+Zhenqiang%3BHong%2C+Huixiao%3BTong%2C+Weida%3BShi%2C+Leming&rft.aulast=Wen&rft.aufirst=Zhining&rft.date=2010-10-07&rft.volume=11&rft.issue=6&rft.spage=S10&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-11-S6-S10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; RNA; Bioinformatics; DNA microarrays; Compression DO - http://dx.doi.org/10.1186/1471-2105-11-S6-S10 ER - TY - JOUR T1 - Rationale, design, and results of the first screening round of a comprehensive, register-based, Chlamydia screening implementation programme in the Netherlands AN - 839684143; 13969148 AB - Implementing Chlamydia trachomatis screening in the Netherlands has been a point of debate for several years. The National Health Council advised against implementing nationwide screening until additional data collected from a pilot project in 2003 suggested that screening by risk profiles could be effective. A continuous increase in infections recorded in the national surveillance database affirmed the need for a more active approach. Here, we describe the rationale, design, and implementation of a Chlamydia screening demonstration programme. A systematic, selective, internet-based Chlamydia screening programme started in April 2008. Letters are sent annually to all 16 to 29-year-old residents of Amsterdam, Rotterdam, and selected municipalities of South Limburg. The letters invite sexually active persons to login to http://www.chlamydiatest.nl with a personal code and to request a test kit. In the lower prevalence area of South Limburg, test kits can only be requested if the internet-based risk assessment exceeds a predefined value. We sent invitations to 261,025 people in the first round. One-fifth of the invitees requested a test kit, of whom 80% sent in a sample for testing. The overall positivity rate was 4.2%. This programme advances Chlamydia control activities in the Netherlands. Insight into the feasibility, effectiveness, cost-effectiveness, and impact of this large-scale screening programme will determine whether the programme will be implemented nationally. JF - BMC Infectious Diseases AU - van Bergen, Jan EAM AU - Fennema, Johannes SA AU - van den Broek, Ingrid VF AU - Brouwers, Elfi EHG AU - de Feijter, Eva M AU - Hoebe, Christian JPA AU - Koekenbier, Rik H AU - Op de Coul, Eline LM AU - van Ravesteijn, Sander M AU - Goetz, Hannelore M AD - Rotterdam Rijnmond Public Health Service, Rotterdam, The Netherlands Y1 - 2010/10/07/ PY - 2010 DA - 2010 Oct 07 SP - 293 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 10 KW - Microbiology Abstracts B: Bacteriology KW - Risk assessment KW - Databases KW - Data processing KW - Chlamydia trachomatis KW - Infection KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839684143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Infectious+Diseases&rft.atitle=Rationale%2C+design%2C+and+results+of+the+first+screening+round+of+a+comprehensive%2C+register-based%2C+Chlamydia+screening+implementation+programme+in+the+Netherlands&rft.au=van+Bergen%2C+Jan+EAM%3BFennema%2C+Johannes+SA%3Bvan+den+Broek%2C+Ingrid+VF%3BBrouwers%2C+Elfi+EHG%3Bde+Feijter%2C+Eva+M%3BHoebe%2C+Christian+JPA%3BKoekenbier%2C+Rik+H%3BOp+de+Coul%2C+Eline+LM%3Bvan+Ravesteijn%2C+Sander+M%3BGoetz%2C+Hannelore+M&rft.aulast=van+Bergen&rft.aufirst=Jan&rft.date=2010-10-07&rft.volume=10&rft.issue=&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=BMC+Infectious+Diseases&rft.issn=1471-2334&rft_id=info:doi/10.1186%2F1471-2334-10-293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Databases; Data processing; Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1186/1471-2334-10-293 ER - TY - JOUR T1 - An in vitro system for studying potential biological mechanisms of human sex differences in susceptibility to acute liver injury. AN - 748976292; 20621171 AB - Women are more susceptible than men to acute liver injury from drugs and other xenobiotics. The biological mechanisms for this sex difference are unknown, but known sex differences in steroid hormone levels and immune response could play a role. A human hepatocyte cell line, HepG2, was cultured for 8 days in either a male hormone, female hormone, or sex hormone-free medium. The cells were then exposed to a mixture of pro-inflammatory cytokines (interleukin (IL)-1beta, IL-6, TNFalpha) for 72h to simulate acute inflammation. Cell viability (total DNA) and various metabolic functions (reactive oxygen species (ROS), neutral and polar lipid (PL) accumulation, mitochondrial membrane potential, cytochrome P450 (CYP) activities) were measured fluorometrically. Acute phase proteins (albumin, IL-1ra) were measured in the culture medium by ELISA. This model gave both significant hormone only effects (ROS, PL accumulation) and cytokine only effects (total DNA, CYP1A, neutral and PL accumulation, albumin, IL-1ra) consistent with known biological responses. Significant hormone-cytokine interactions were observed for several endpoints (total DNA, ROS, neutral and PL accumulation, albumin). These findings suggest that sex hormones and pro-inflammatory cytokines can interact to alter liver metabolism in ways that may contribute to the marked sex difference in susceptibility to chemical-induced acute liver injury. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Flynn, Thomas J AU - Ferguson, Martine S AD - FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States. thomas.flynn@fda.hhs.gov Y1 - 2010/10/05/ PY - 2010 DA - 2010 Oct 05 SP - 232 EP - 236 VL - 198 IS - 2 KW - Acute-Phase Proteins KW - 0 KW - Culture Media KW - Cytokines KW - Gonadal Steroid Hormones KW - Reactive Oxygen Species KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Acute Disease KW - Reactive Oxygen Species -- metabolism KW - Humans KW - Cell Culture Techniques KW - Cytochrome P-450 Enzyme System -- metabolism KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Hep G2 Cells KW - Enzyme-Linked Immunosorbent Assay KW - Acute-Phase Proteins -- metabolism KW - Female KW - Male KW - Chemical and Drug Induced Liver Injury -- etiology KW - Cytokines -- pharmacology KW - Sex Characteristics KW - Gonadal Steroid Hormones -- pharmacology KW - Gonadal Steroid Hormones -- metabolism KW - Cytokines -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Chemical and Drug Induced Liver Injury -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748976292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=An+in+vitro+system+for+studying+potential+biological+mechanisms+of+human+sex+differences+in+susceptibility+to+acute+liver+injury.&rft.au=Flynn%2C+Thomas+J%3BFerguson%2C+Martine+S&rft.aulast=Flynn&rft.aufirst=Thomas&rft.date=2010-10-05&rft.volume=285&rft.issue=45&rft.spage=34447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M110.133579 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-10 N1 - Date created - 2010-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.toxlet.2010.07.003 ER - TY - JOUR T1 - Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes AN - 849440225; 13969676 AB - Multi-walled carbon nanotubes (MWCNT) are new manufactured nanomaterials with a wide spectrum of commercial applications. The durability and fiber-like dimensions (mean length 3.9 km long 49 nm diameter) of MWCNT suggest that these fibers may migrate to and have toxicity within the pleural region. To address whether the pleura received a significant and persistent exposure, C57BL/6J mice were exposed by pharyngeal aspiration to 10, 20, 40 and 80 kg MWCNT or vehicle and the distribution of MWCNT penetrations determined at 1, 7, 28 and 56 days after exposure. Following lung fixation and sectioning, morphometric methods were used to determine the distribution of MWCNT and the number of MWCNT fiber penetrations of three barriers: alveolar epithelium (alveolar penetrations), the alveolar epithelium immediately adjacent to the pleura (subpleural tissue), and visceral pleural surface (intrapleural space). At 1 day 18%, 81.6% and 0.6% of the MWCNT lung burden was in the airway, the alveolar, and the subpleural regions, respectively. There was an initial, high density of penetrations into the subpleural tissue and the intrapleural space one day following aspiration which appeared to decrease due to clearance by alveolar macrophages and/or lymphatics by day 7. However, the density of penetrations increased to steady state levels in the subpleural tissue and intrapleural from day 28 - 56. At day 56 approximately 1 in every 400 fiber penetrations was in either the subpleural tissue or intrapleural space. Numerous penetrations into macrophages in the alveolar airspaces throughout the lungs were demonstrated at all times but are not included in the counts presented. The results document that MWCNT penetrations of alveolar macrophages, the alveolar wall, and visceral pleura are both frequent and sustained. In addition, the findings demonstrate the need to investigate the chronic toxicity of MWCNT at these sites. JF - Particle and Fibre Toxicology AU - Mercer, Robert R AU - Hubbs, Ann F AU - Scabilloni, James F AU - Wang, Liying AU - Battelli, Lori A AU - Schwegler-Berry, Diane AU - Castranova, Vincent AU - Porter, Dale W AD - Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA Y1 - 2010/10/04/ PY - 2010 DA - 2010 Oct 04 SP - 28 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 7 KW - Toxicology Abstracts KW - Macrophages KW - Pharynx KW - Toxicity KW - Migration KW - Alveoli KW - Fibers KW - Pleura KW - Carbon KW - Lung KW - Chronic toxicity KW - Sectioning KW - nanotubes KW - Epithelium KW - Cell migration KW - nanotechnology KW - Respiratory tract KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/849440225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+Fibre+Toxicology&rft.atitle=Distribution+and+persistence+of+pleural+penetrations+by+multi-walled+carbon+nanotubes&rft.au=Mercer%2C+Robert+R%3BHubbs%2C+Ann+F%3BScabilloni%2C+James+F%3BWang%2C+Liying%3BBattelli%2C+Lori+A%3BSchwegler-Berry%2C+Diane%3BCastranova%2C+Vincent%3BPorter%2C+Dale+W&rft.aulast=Mercer&rft.aufirst=Robert&rft.date=2010-10-04&rft.volume=7&rft.issue=&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Particle+and+Fibre+Toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2F1743-8977-7-28 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Pharynx; Toxicity; Migration; Alveoli; Pleura; Fibers; Carbon; Lung; Chronic toxicity; Sectioning; nanotubes; Epithelium; Cell migration; Respiratory tract; nanotechnology DO - http://dx.doi.org/10.1186/1743-8977-7-28 ER - TY - JOUR T1 - The in vivo pig-a gene mutation assay, a potential tool for regulatory safety assessment AN - 968157947; 15033742 AB - The Pig-a (phosphatidylinositol glycan, Class A) gene codes for a catalytic subunit of the N-acetylglucosamine transferase complex involved in an early step of glycosylphosphatidyl inositol (GPI) cell surface anchor synthesis. Pig-a is the only gene involved in GPI anchor synthesis that is on the X-chromosome, and research into the origins of an acquired genetic disease involving GPI anchor deficiency (paroxysmal nocturnal hemoglobinuria) indicates that cells lacking GPI anchors, or GPI-anchored cell surface proteins, almost always have mutations in the Pig-a gene. These properties of the Pig-a gene and the GPI anchor system have been exploited in a series of assays for measuring in vivo gene mutation in blood cells from humans, rats, mice, and monkeys. In rats, flow cytometric measurement of Pig-a mutation in red blood cells requires microliter volumes of blood and data can be generated in hours. Spontaneous mutant frequencies are relatively low (<5 X 10-6) and rats treated with multiple doses of the potent mutagen, N-ethyl-N-nitrosourea, display Pig-a mutant frequencies that are close to the sum of the frequencies produced by the individual exposures. A general observation is that induced mutant frequencies are manifested earlier in reticulocytes (about 2 weeks after treatment) than in total red blood cells (about 2 months after exposure). Based on data from a limited number of test agents, the assay shows promise for regulatory applications, including integration of gene mutation measurement into repeat-dose toxicology studies. Environ. Mol. Mutagen., 2010. Published 2010 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Dobrovolsky, Vasily N AU - Miura, Daishiro AU - Heflich, Robert H AU - Dertinger, Stephen D AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, vasily.dobrovolsky@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 825 EP - 835 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 8-9 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts KW - Paroxysmal nocturnal hemoglobinuria KW - Cell surface KW - Mutagens KW - phosphatidylinositol KW - Erythrocytes KW - exploitation KW - Mutant frequency KW - N-Acetylglucosamine KW - Polysaccharides KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Integration KW - Ethyl nitrosourea KW - Glycosylphosphatidylinositol KW - Blood cells KW - Toxicology KW - Data processing KW - Point mutation KW - Assays KW - Catalytic subunits KW - Mice KW - Proteins KW - Mutation KW - Reticulocytes KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/968157947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=The+in+vivo+pig-a+gene+mutation+assay%2C+a+potential+tool+for+regulatory+safety+assessment&rft.au=Dobrovolsky%2C+Vasily+N%3BMiura%2C+Daishiro%3BHeflich%2C+Robert+H%3BDertinger%2C+Stephen+D&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2010-10-01&rft.volume=51&rft.issue=8-9&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20627 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20627/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-04-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Paroxysmal nocturnal hemoglobinuria; Mutagens; Cell surface; Data processing; phosphatidylinositol; Point mutation; Erythrocytes; Catalytic subunits; Mutant frequency; N-Acetylglucosamine; Polysaccharides; Mutagenesis; Flow cytometry; Integration; Ethyl nitrosourea; Glycosylphosphatidylinositol; Blood cells; Reticulocytes; Rats; Assays; Proteins; Mice; exploitation; Mutation; Toxicology; Mutants DO - http://dx.doi.org/10.1002/em.20627 ER - TY - JOUR T1 - Training Outcomes from the Samaritans of New York Suicide Awareness and Prevention Programme among Community- and School-Based Staff AN - 954599537; 14310363 AB - The Samaritans of New York public education suicide awareness and prevention programme is designed to train lay and professional staff on effective suicide prevention practices and how to 'befriend' a person in crisis. However, little is known about the individual-level characteristics of staff who attend these trainings. Community- and school-based staff (N = 365) completed pre- and post-training measures of self-efficacy regarding their knowledge about suicide and suicide prevention and their ability to intervene with individuals at risk for suicide. Results indicate increased self-efficacy after suicide prevention training (M = 3.7, SD = 0.6) than before (M = 3.3, SD = 0.7) (t = -13.24, p < 0.05). Trainees with higher levels of education and previous contact with suicidal individuals were significantly more likely to indicate gains in self-efficacy after training. JF - British Journal of Social Work AU - Clark, Tanisha R AU - Matthieu, Monica M AU - Ross, Alan AU - Knox, Kerry L AD - Tanisha R. Clark has a BA from Spelman College in Atlanta, Georgia, majoring in psychology, and was an NIMH undergraduate research fellow through Atlanta University Center NIMH-Career Opportunities in Research (AUC NIMH-COR). Ms Clark served as a Research Assistant at the Center for Mental Health Services Research at the George Warren Brown School of Social Work, Washington University in St Louis and the Department of Veterans Affairs Medical Center in St Louis, Missouri, as part of her summer research experience for AUC NIMH-COR. Monica M. Matthieu, Ph.D., LCSW, is a Research Assistant Professor at the George Warren Brown School of Social Work, Washington University in St Louis, and a Research Social Worker at the Department of Veterans Affairs Medical Center in St Louis, Missouri. Alan Ross, M.A., is the Executive Director of the Samaritans of New York, Inc., New York, NY. Kerry L. Knox, Ph.D., is an Associate Professor in the Department of Psychiatry, University of Rochester, mmatthieu@wustl.edu Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2223 EP - 2238 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 40 IS - 7 SN - 0045-3102, 0045-3102 KW - Risk Abstracts KW - Education KW - Training KW - crises KW - prevention KW - suicide KW - USA, New York KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954599537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Social+Work&rft.atitle=Training+Outcomes+from+the+Samaritans+of+New+York+Suicide+Awareness+and+Prevention+Programme+among+Community-+and+School-Based+Staff&rft.au=Clark%2C+Tanisha+R%3BMatthieu%2C+Monica+M%3BRoss%2C+Alan%3BKnox%2C+Kerry+L&rft.aulast=Clark&rft.aufirst=Tanisha&rft.date=2010-10-01&rft.volume=40&rft.issue=7&rft.spage=2223&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Social+Work&rft.issn=00453102&rft_id=info:doi/10.1093%2Fbjsw%2Fbcq016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Education; Training; crises; prevention; suicide; USA, New York DO - http://dx.doi.org/10.1093/bjsw/bcq016 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys AN - 954575103; 13680104 AB - Bisphenol A (BPA) is a high-production volume industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of >90% of Americans aged 6-60 is controversial because of the potential for endocrine disruption, particularly during perinatal development, as suggested by in vitro, experimental animal, and epidemiological studies. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal rhesus monkeys by oral (PND 5, 35, 70) and intravenous injection (PND 77) routes using d6-BPA to avoid sample contamination. The concentration-time profiles observed in adult monkeys following oral administration of 100I14g/kg bw were remarkably similar to those previously reported in human volunteers given a similar dose; moreover, minimal pharmacokinetic differences were observed between neonatal and adult monkeys for the receptor-active aglycone form of BPA. Circulating concentrations of BPA aglycone were quite low following oral administration (< 1% of total), which reflects the redundancy of active UDP-glucuronosyl transferase isoforms in both gut and liver. No age-related changes were seen in internal exposure metrics for aglycone BPA in monkeys, a result clearly different from developing rats where significant inverse age-related changes, based on immaturity of Phase II metabolism and renal excretion, were recently reported. These observations imply that any toxicological effect observed in rats from early postnatal exposures to BPA could over-predict those possible in primates of the same age, based on significantly higher internal exposures and overall immaturity at birth. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Woodling, Kellie A AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, daniel.doerge@fda.hhs.gov Y1 - 2010/10/01/ PY - 2010 DA - 2010 Oct 01 SP - 1 EP - 11 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 248 IS - 1 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Aglycones KW - Macaca mulatta KW - Neonates KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+neonatal+and+adult+rhesus+monkeys&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BWoodling%2C+Kellie+A%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2010-10-01&rft.volume=248&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Aglycones; Neonates; Macaca mulatta DO - http://dx.doi.org/10.1016/j.taap.2010.07.009 ER - TY - JOUR T1 - Simple Respiratory Protection-Evaluation of the Filtration Performance of Cloth Masks and Common Fabric Materials Against 20-1000 nm Size Particles AN - 899129103; 13842714 AB - A shortage of disposable filtering facepiece respirators can be expected during a pandemic respiratory infection such as influenza A. Some individuals may want to use common fabric materials for respiratory protection because of shortage or affordability reasons. To address the filtration performance of common fabric materials against nano-size particles including viruses, five major categories of fabric materials including sweatshirts, T-shirts, towels, scarves, and cloth masks were tested for polydisperse and monodisperse aerosols (20-1000 nm) at two different face velocities (5.5 and 16.5 cm s-1) and compared with the penetration levels for N95 respirator filter media. The results showed that cloth masks and other fabric materials tested in the study had 40-90% instantaneous penetration levels against polydisperse NaCl aerosols employed in the National Institute for Occupational Safety and Health particulate respirator test protocol at 5.5 cm s-1. Similarly, varying levels of penetrations (9-98%) were obtained for different size monodisperse NaCl aerosol particles in the 20-1000 nm range. The penetration levels of these fabric materials against both polydisperse and monodisperse aerosols were much higher than the penetrations for the control N95 respirator filter media. At 16.5 cm s-1 face velocity, monodisperse aerosol penetrations slightly increased, while polydisperse aerosol penetrations showed no significant effect except one fabric mask with an increase. Results obtained in the study show that common fabric materials may provide marginal protection against nanoparticles including those in the size ranges of virus-containing particles in exhaled breath. JF - Annals of Occupational Hygiene AU - Rengasamy, Samy AU - Eimer, Benjamin AU - Shaffer, Ronald E AD - National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory-Technology Research Branch, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 789 EP - 798 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 7 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Particle size KW - Aerosols KW - Viruses KW - Velocity KW - Particulates KW - Protective equipment KW - Fabrics KW - Filtration KW - Respirators KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899129103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Simple+Respiratory+Protection-Evaluation+of+the+Filtration+Performance+of+Cloth+Masks+and+Common+Fabric+Materials+Against+20-1000+nm+Size+Particles&rft.au=Rengasamy%2C+Samy%3BEimer%2C+Benjamin%3BShaffer%2C+Ronald+E&rft.aulast=Rengasamy&rft.aufirst=Samy&rft.date=2010-10-01&rft.volume=54&rft.issue=7&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Particle size; Fabrics; Filtration; Aerosols; Viruses; Velocity; Particulates; Respirators; Protective equipment ER - TY - JOUR T1 - Occupational Fatalities in the United States Commercial Fishing Industry, 2000-2009 AN - 888110536; 15523721 AB - The occupational fatality rate among commercial fishermen decreased in the United States during 1992-2008; however, commercial fishing continues to be one of the most dangerous occupations in the United States, with an average annual fatality rate of 129 deaths per 100,000 fishermen in 2008. By contrast, the average annual occupational fatality rate among all US workers during the same period was four deaths per 100,000 workers. During the 1990s, numerous safety interventions were developed for Alaska fisheries that resulted in a significant decline in the state's commercial fishing fatality rate. In 2007, the National Institute for Occupational Safety and Health (NIOSH) expanded surveillance of commercial fishing fatalities to the rest of the United States. The purpose of this report is to identify the hazards and risk factors for all causes of occupational mortality in the US commercial fishing industry, and to explore how those hazards and risk factors differ among fisheries and locations. During 2000-2009, 504 commercial fishing fatalities occurred in the United States. Most (261, 52%) occurred following a vessel disaster (defined as a sinking, capsizing, or other event in which the crew was forced to abandon ship) or a fall overboard (155, 31%). Fatalities occurred in Alaska (133, 26%), Northeast (124, 25%), Gulf of Mexico (116, 23%), West Coast (83, 16%), and the Mid- and South Atlantic (41, 8%) regions. Fatalities occurred most commonly while fishing for shellfish (226, 47%), groundfish (144, 30%) and pelagic fish (97, 20%). Average annual fatality rates were calculated for selected fisheries. The Northeast multispecies groundfish fleet had the highest average annual fatality rate (600 deaths per 100,000 full-time equivalent [FTE] fishermen) followed by the Atlantic scallop fleet (425 deaths per 100,000 FTE fishermen) and the West Coast Dungeness crab fleet (310 deaths per 100,000 FTE fishermen). To reduce fatalities among fishermen at greatest risk, additional prevention measures tailored to specific high-risk fisheries should be considered. JF - Journal of Agromedicine AU - Lincoln, Jennifer M AU - Lucas, Devin L AD - Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health, Alaska Pacific Regional Office, Anchorage, Alaska, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 343 EP - 350 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 4 SN - 1059-924X, 1059-924X KW - ASFA 1: Biological Sciences & Living Resources; Risk Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Health & Safety Science Abstracts KW - Ships KW - Biological surveys KW - Mortality KW - Fishing vessels KW - Decapoda KW - Settling rate KW - Crustacea KW - Disasters KW - AS, South Atlantic KW - INE, USA, Alaska KW - Fishery development KW - ASW, Mexico Gulf KW - Hazards KW - Commercial fishing KW - Risk factors KW - Fisheries KW - Depleted stocks KW - Fish KW - Shellfish KW - Mortality causes KW - Q5 08504:Effects on organisms KW - Q1 08442:Population dynamics KW - O 5020:Fisheries and Fishery Biology KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888110536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Occupational+Fatalities+in+the+United+States+Commercial+Fishing+Industry%2C+2000-2009&rft.au=Lincoln%2C+Jennifer+M%3BLucas%2C+Devin+L&rft.aulast=Lincoln&rft.aufirst=Jennifer&rft.date=2010-10-01&rft.volume=15&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.509700 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Biological surveys; Hazards; Commercial fishing; Fishing vessels; Settling rate; Depleted stocks; Disasters; Fishery development; Mortality causes; Ships; Mortality; Crustacea; Risk factors; Fisheries; Shellfish; Fish; Decapoda; ASW, Mexico Gulf; INE, USA, Alaska; AS, South Atlantic DO - http://dx.doi.org/10.1080/1059924X.2010.509700 ER - TY - JOUR T1 - pH effect on the synthesis, shear properties, and homogeneity of iron-crosslinked hyaluronic acid-based gel/adhesion barrier AN - 883045941; 15243612 AB - Iron-crosslinked hyaluronic acid hydrogel (FeHA) has been used to reduce postsurgical adhesions in patients undergoing open, gynecological surgery. The performance of FeHA gel as an adhesion barrier device is influenced by many factors, including the physicochemical gel properties, which, in turn, depend on the chemistry and conditions of the device manufacturing. In this work, we demonstrate the effect of reaction pH on rheology and homogeneity of FeHA gels formulated in house and also compare the viscoelastic properties of FeHA gels with that of uncrosslinked HA solution of similar HA concentration and ionic strength. Dynamic mechanical analyses provide evidence that the reaction of HA with Fe(III) ions leads to the formation of 'weak' gels. The viscoelastic properties and homogeneity of FeHA gels vary depending on the pH at which crosslinking was initiated. When solution pH, at the start of crosslinking, varied between 1.5 and 3, the low-shear rate viscosity of FeHA varied between 10,000 and 40,000 cPoise (10-40 Pa s). The highest steady-state shear viscosity and viscoelasticity were measured when pH was around 2.6, which is similar to the pH-dependent viscoelasticity of pure HA solution. Initiating HA crosslinking at pH 3 caused instantaneous gel precipitation and inhomogeneities. Sensitivity of FeHA gel properties to small variations in reaction pH clearly supports the need for a tight manufacturing control during medical device fabrication. [copy 2010 Wiley Periodicals, Inc.* J Biomed Mater Res Part B: Appl Biomater, 2010. JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Isayeva, Irada AU - Das, Srilekha Sarkar AU - Chang, Andrew AU - Defoe, Jacqueline AU - Do Luu, Hoan-My AU - Vorvolakos, Katherine AU - Patwardhan, Dinesh AU - Whang, Joyce AU - Pollack, Steven AD - Division of Chemistry and Materials Science (DCMS)/Office of Science and Engineering Laboratories (OSEL)/Center for Devices and Radiological Health (CDRH)/Food and Dug Administration (FDA), Silver Spring, Maryland 20903, irada.isayeva@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 9 EP - 18 PB - Wiley-Blackwell VL - 95B IS - 1 SN - 1552-4981, 1552-4981 KW - Biotechnology and Bioengineering Abstracts KW - Ions KW - Hyaluronic acid KW - Gel precipitation KW - Rheology KW - Houses KW - Viscosity KW - hydrogels KW - Ionic strength KW - Surgery KW - pH effects KW - viscoelasticity KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883045941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=pH+effect+on+the+synthesis%2C+shear+properties%2C+and+homogeneity+of+iron-crosslinked+hyaluronic+acid-based+gel%2Fadhesion+barrier&rft.au=Isayeva%2C+Irada%3BDas%2C+Srilekha+Sarkar%3BChang%2C+Andrew%3BDefoe%2C+Jacqueline%3BDo+Luu%2C+Hoan-My%3BVorvolakos%2C+Katherine%3BPatwardhan%2C+Dinesh%3BWhang%2C+Joyce%3BPollack%2C+Steven&rft.aulast=Isayeva&rft.aufirst=Irada&rft.date=2010-10-01&rft.volume=95B&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=15524981&rft_id=info:doi/10.1002%2Fjbm.b.31677 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.31677/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Hyaluronic acid; Ions; Houses; Rheology; Gel precipitation; Viscosity; Ionic strength; hydrogels; Surgery; pH effects; viscoelasticity DO - http://dx.doi.org/10.1002/jbm.b.31677 ER - TY - RPRT T1 - A Year in Head Start: Children, Families and Programs. ACF-ORPRE Report AN - 864941911; ED517213 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers and program managers, as well as direct observations of classroom quality. This brief profiles the 3- and 4-year-old Head Start children and families who were newly enrolled in the program in fall 2006 (see Tarullo et al. 2008) and are still attending in spring 2007. The first section of the report provides background on the study methodology and sample. The next offers information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status. It includes information on parent involvement in Head Start and level of satisfaction with their own and their children's Head Start experiences. The following section chronicles children's developmental progress over the Head Start year, considering whether these outcomes vary by age, gender, race/ethnicity, or risk status. Changes in children's skills and development during the program year reflect a range of influences, including maturation, program and family influences, and other influences in children's lives. Presented next are the characteristics of their teachers and classrooms, including measures of observed quality. Finally, the last section examines the relationships among child, family, and classroom factors and children's outcomes. (Contains 2 tables, 16 figures and 52 notes.) [For related report, "Data Tables for FACES 2006: A Year in Head Start Report. ACF-ORPRE Report", see ED517209.] AU - Aikens, Nikki AU - Tarullo, Louisa AU - Hulsey, Lara AU - Ross, Christine AU - West, Jerry AU - Xue, Yange Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 41 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Teacher Characteristics KW - Educational Indicators KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Standardized Tests KW - Achievement Gains KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Educational Environment KW - Classroom Observation Techniques KW - Child Development KW - Parent Participation KW - Parent Attitudes KW - Program Evaluation KW - Interviews KW - Educational Assessment KW - Preschool Evaluation KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941911?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Data Tables for FACES 2006: A Year in Head Start Report. ACF-ORPRE Report AN - 864941411; ED517209 AB - The Head Start Family and Child Experiences Survey (FACES) was first launched in 1997 as a periodic longitudinal study of program performance. Successive nationally representative samples of Head Start children, their families, classrooms, and programs provide descriptive information on the population served; staff qualifications, credentials, beliefs and opinions; classroom practices and quality measures; and child and family outcomes. FACES includes a battery of direct child assessments across multiple domains. It also comprises interviews with the child's parents, teachers and program managers, as well as direct observations of classroom quality. This set of tables is designed to accompany a research brief which profiles the 3- and 4-year-old Head Start children and families who were newly enrolled in the program in fall 2006 and are still attending in spring 2007 (see Aikens et al. 2010). Following an introduction to the study methodology and sample, the tables in the first section provide information on the children's characteristics, family demographics, and home life, including language background, educational environment of the home, family routines, and socioeconomic risk status in spring 2007. These tables also include information on parent involvement in Head Start and level of satisfaction with their own and their children's Head Start experiences. The next sections, on cognitive and social-emotional/health outcomes in spring 2007, chronicle children's developmental progress over the Head Start year. They examine whether these outcomes vary by age, gender, race/ethnicity, or risk status. The following section presents the characteristics of their teachers and classrooms, including measures of observed quality in spring 2007. Subsequent sections provide information on fall-spring change in family environment, child cognitive, social-emotional, and health outcomes. The next section examines the relationships among child, family, and classroom factors and children's outcomes; the methods used for those analyses appear in advance of the tables in that section. The final section provides tables of standard deviations and standard errors. (Contains 183 tables and 12 footnotes.) [For related report, "A Year in Head Start: Children, Families and Programs. ACF-ORPRE Report", see ED517213.] AU - Hulsey, Lara AU - Aikens, Nikki AU - Xue, Yange AU - Tarullo, Louisa AU - West, Jerry Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 227 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Classroom Environment KW - Student Characteristics KW - Teacher Attitudes KW - Academic Achievement KW - Family Life KW - Student Records KW - Outcomes of Education KW - Participant Satisfaction KW - Demography KW - Classroom Observation Techniques KW - Child Development KW - Statistical Data KW - Program Evaluation KW - Population Trends KW - Preschool Evaluation KW - Family Environment KW - Gender Differences KW - Teacher Characteristics KW - Racial Differences KW - Achievement Gains KW - Educational Environment KW - Parent Participation KW - Parent Attitudes KW - Interviews KW - Tables (Data) KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941411?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Conceptual Frameworks for Child Care Decision-Making. White Paper AN - 864939896; ED517547 AB - This working paper is one in a series of projects initiated by the Administration for Children and Families (ACF) to improve knowledge for child care researchers and policy makers about parental child care decision making. In this paper, the authors identify three distinct conceptual frameworks for understanding child care decisions--a rational consumer choice framework, a heuristics and biases framework, and a social network framework--and review the major assumptions, contributions, and possible limitations of each of these frameworks. They then discuss an integrated conceptual model, the accommodation model that draws from each of these frameworks. The first three frameworks come primarily from the fields of economics, psychology, and sociology, respectively. It is the authors' sense that most research about child care decision making has been informed by the theories, assumptions, and empirical methods of one or more of these frameworks, either explicitly or implicitly, and they provide some examples and elaborate the basic tenets of each framework. The integrative accommodation model was first presented by Marcia Meyers and Lucy Jordan (2006). They develop and elaborate this model more fully here with explicit attention to its relation to the rational consumer choice framework, the heuristics and biases framework, and the social network frameworks. These frameworks are presented as complementary, rather than mutually exclusive. For a process as complex as parental child care decisions, each can provide a different and useful lens through which to understand unique aspects of the factors, processes and outcomes of parental child care decisions. When considered together, they believe they may inform one another and the development of more integrative models, such as the accommodation model presented here. It is the authors' hope that researchers working primarily within one of the conceptual frameworks discussed here will benefit from learning about other frameworks. In some cases, this may simply suggest additional or new variables to consider when specifying a particular model, while still working from the same conceptual framework. In other cases, it may result in integrative approaches that address multiple dimensions of the decision making process--dimensions that may not be as obvious when working within a single framework. In the concluding section the authors discuss some of the issues and the implications for future research. A goal of this paper is to advance knowledge that can inform public policy efforts. Given that the Child Care Development Fund (CCDF) has an explicit goal of supporting parental choice for child care, it is critical that they expand and deepen everyone's knowledge about the processes through which parents make decisions and the consequences for the choices they make (Zaslow, Halle, Guzman, Lavelle, Keith, Berry, & Dent, 2006). The different perspectives offered by each of the three frameworks and the integrative accommodation model may help policy makers identify the policy and program levers that can prove important at different stages of the decision making process. (Contains 7 footnotes.) AU - Chaudry, Ajay AU - Henly, Julia AU - Meyers, Marcia Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 44 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Social Influences KW - Context Effect KW - Sociology KW - Heuristics KW - Psychology KW - Child Care KW - Public Policy KW - Decision Making KW - Models KW - Holistic Approach KW - Social Attitudes KW - Economics KW - Researchers KW - Theories KW - Social Networks KW - Parents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864939896?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Protecting the planet and its people: How do interventions to promote environmental sustainability and occupational safety and health overlap? AN - 856762591; 13998130 AB - Problem: The challenges of both occupational safety and health and environmental sustainability require large-scale behavior change for meaningful improvements to occur. Environmental sustainability, or the 'green movement' has received far more attention recently, and certain strategies and recommendations from interventions designed for promoting pro-environmental behaviors may inform efforts to intervene on critical behaviors for improving occupational safety and health. Method: A survey of the literature regarding behavioral interventions for both environmental sustainability and occupational safety and health was conducted. Several theoretical approaches are reviewed, and successful approaches from each domain are identified, as well as parallel challenges and points for crossover. Recommendations are provided for adapting environmental sustainability intervention approaches for occupational safety and health applications. Impact on Industry: Safety and health leaders may achieve sustainable improvements in worker safety and health by harnessing the momentum of the green movement and adapting successful intervention approaches from the environmental sustainability domain. JF - Journal of Safety Research AU - Cunningham, Thomas R AU - Galloway-Williams, Neville AU - Geller, EScott AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-10, Cincinnati, OH 45226, tcunningham@cdc.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 407 EP - 416 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 5 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Occupational safety KW - Sustainable development KW - green revolution KW - adaptability KW - intervention KW - Reviews KW - sustainability KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856762591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Pharmacogenomics+and+adverse+drug+reactions&rft.au=Amur%2C+Shashi%3BZineh%2C+Issam%3BAbernethy%2C+Darrell+R%3BHuang%2C+Shiew-Mei%3BLesko%2C+Lawrence+J&rft.aulast=Amur&rft.aufirst=Shashi&rft.date=2010-11-01&rft.volume=7&rft.issue=6&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/10.2217%2Fpme.10.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Reviews; intervention; Occupational safety; Sustainable development; green revolution; sustainability; adaptability DO - http://dx.doi.org/10.1016/j.jsr.2010.08.002 ER - TY - JOUR T1 - Assessing the performance of various restraints on ambulance patient compartment workers during crash events AN - 855695980; 14060115 AB - The inability of emergency medical service (EMS) workers to remain safely restrained while treating patients in the patient compartment of a moving ambulance has been identified as a key impediment to EMS worker safety in North America. It has been hypothesised that restraint systems designed to provide mobility while offering the ability to lock during an impact or sudden manoeuvre, could greatly enhance worker safety in the back of ambulances. Through a series of 33 sled and crash tests impacting the front, side, and rear of simulated and actual ambulance patient compartments, the National Institute for Occupational Safety and Health examined the biomechanical and kinematic effects of two-, four- and five-point restraints on 95th percentile male Hybrid III anthropomorphic test devices. Results indicate that the inclusion of restraint systems offering mobility have the potential to improve worker safety under many working conditions in this unique work environment. JF - International Journal of Crashworthiness AU - Green, J D AU - Yannaccone, J R AU - Current, R S AU - Sicher, LA AU - Moore, PH AU - Whitman, G R AD - National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 517 EP - 541 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 15 IS - 5 SN - 1358-8265, 1358-8265 KW - Health & Safety Science Abstracts KW - crash testing KW - restraints KW - neck injury KW - head injury criteria (HIC) KW - side-facing seating KW - crashworthiness KW - North America KW - hybrids KW - Mobility KW - Occupational safety KW - biomechanics KW - emergency medical services KW - working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855695980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Crashworthiness&rft.atitle=Assessing+the+performance+of+various+restraints+on+ambulance+patient+compartment+workers+during+crash+events&rft.au=Green%2C+J+D%3BYannaccone%2C+J+R%3BCurrent%2C+R+S%3BSicher%2C+LA%3BMoore%2C+PH%3BWhitman%2C+G+R&rft.aulast=Green&rft.aufirst=J&rft.date=2010-10-01&rft.volume=15&rft.issue=5&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Crashworthiness&rft.issn=13588265&rft_id=info:doi/10.1080%2F13588265.2010.489402 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Number of references - 51 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - crashworthiness; hybrids; Mobility; biomechanics; Occupational safety; working conditions; emergency medical services; North America DO - http://dx.doi.org/10.1080/13588265.2010.489402 ER - TY - JOUR T1 - Information-Theoretic Approach for Analyzing Bias and Variance in Lung Nodule Size Estimation With CT: A Phantom Study AN - 855690743; 14109016 AB - This work is a part of our more general effort to probe the interrelated factors impacting the accuracy and precision of lung nodule measurement tasks. For such a task a low-bias size estimator is needed so that the true effect of factors such as acquisition and reconstruction parameters, nodule characteristics and others can be assessed. Towards this goal, we have developed a matched filter based on an adaptive model of the object acquisition and reconstruction process. Our model derives simulated reconstructed data of nodule objects (templates) which are then matched to computed tomography data produced from imaging the actual nodule in a phantom study using corresponding imaging parameters. This approach incorporates the properties of the imaging system and their effect on the discrete 3-D representation of the object of interest. Using a sum of absolute differences cost function, the derived matched filter demonstrated low bias and variance in the volume estimation of spherical synthetic nodules ranging in density from - 630 to + 100 ~ rm HU and in size from 5 to 10 mm. This work could potentially lead to better understanding of sources of error in the task of lung nodule size measurements and may lead to new techniques to account for those errors. JF - IEEE Transactions on Medical Imaging AU - Gavrielides, Marios A AU - Zeng, Rongping AU - Kinnard, Lisa M AU - Myers, Kyle J AU - Petrick, Nicholas AD - Division of Imaging and Applied Mathematics (DIAM), Office of Science and Engineering Laboratories (OSEL), Center for Devices and Radiological Health (CDRH), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1795 EP - 1807 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 29 IS - 10 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Data processing KW - Computed tomography KW - Lung nodules KW - Probes KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/855690743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Information-Theoretic+Approach+for+Analyzing+Bias+and+Variance+in+Lung+Nodule+Size+Estimation+With+CT%3A+A+Phantom+Study&rft.au=Gavrielides%2C+Marios+A%3BZeng%2C+Rongping%3BKinnard%2C+Lisa+M%3BMyers%2C+Kyle+J%3BPetrick%2C+Nicholas&rft.aulast=Gavrielides&rft.aufirst=Marios&rft.date=2010-10-01&rft.volume=29&rft.issue=10&rft.spage=1795&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2052466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Filters; Data processing; Computed tomography; Probes; Lung nodules; Models DO - http://dx.doi.org/10.1109/TMI.2010.2052466 ER - TY - JOUR T1 - Considerations for Clinical Trial Design and Data Analyses of Thorough QT Studies Using Drug-Drug Interaction AN - 853480026; 14088395 JF - Journal of Clinical Pharmacology AU - Zhu, Hao AU - Wang, Yaning AU - Gobburu, Jogarao V AU - Garnett, Christine E AD - Division of Pharmacometrics, Office of Clinical Pharmacology, CDER, Food and Drug Administration, Silver Spring, Maryland, Hao.Zhu@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1106 EP - 1111 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 50 IS - 10 SN - 0091-2700, 0091-2700 KW - Health & Safety Science Abstracts KW - clinical trials KW - drug interaction KW - Design KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853480026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Considerations+for+Clinical+Trial+Design+and+Data+Analyses+of+Thorough+QT+Studies+Using+Drug-Drug+Interaction&rft.au=Zhu%2C+Hao%3BWang%2C+Yaning%3BGobburu%2C+Jogarao+V%3BGarnett%2C+Christine+E&rft.aulast=Zhu&rft.aufirst=Hao&rft.date=2010-10-01&rft.volume=50&rft.issue=10&rft.spage=1106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1177%2F0091270009358710 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - clinical trials; drug interaction; Design DO - http://dx.doi.org/10.1177/0091270009358710 ER - TY - JOUR T1 - Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers AN - 839687391; 13984200 AB - Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drags. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Results: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drags measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Conclusions: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations. JF - Journal of Occupational and Environmental Medicine AU - Connor, TH AU - DeBord, D G AU - Pretty, J R AU - Oliver AU - Roth, T S AU - Lees, PSJ AU - Krieg, EF Jr AU - Rogers, B AU - Escalante, C P AU - Toennis, CA AU - Clark, J C AU - Johnson, B C AU - McDiarmid, MA AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, tmc6@cdc.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1019 EP - 1027 VL - 52 IS - 10 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts KW - 5-Fluorouracil KW - Contamination KW - Urine KW - Nursing KW - Antineoplastic drugs KW - Comet assay KW - Cyclophosphamide KW - Drugs KW - Occupational exposure KW - Medical personnel KW - Cancer KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839687391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Evaluation+of+Antineoplastic+Drug+Exposure+of+Health+Care+Workers+at+Three+University-Based+US+Cancer+Centers&rft.au=Connor%2C+TH%3BDeBord%2C+D+G%3BPretty%2C+J+R%3BOliver%3BRoth%2C+T+S%3BLees%2C+PSJ%3BKrieg%2C+EF+Jr%3BRogers%2C+B%3BEscalante%2C+C+P%3BToennis%2C+CA%3BClark%2C+J+C%3BJohnson%2C+B+C%3BMcDiarmid%2C+MA&rft.aulast=Connor&rft.aufirst=TH&rft.date=2010-10-01&rft.volume=52&rft.issue=10&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181f72b63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - 5-Fluorouracil; Contamination; Urine; Nursing; Antineoplastic drugs; Cyclophosphamide; Comet assay; Drugs; Cancer; Medical personnel; Occupational exposure DO - http://dx.doi.org/10.1097/JOM.0b013e3181f72b63 ER - TY - JOUR T1 - Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin AN - 839678977; 13913485 AB - The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. The overall production of ciprofloxacin was slightly higher in steers than in cows (metabolite ratio: 64% and 59%, respectively). There was no significant difference in plasma protein binding of enrofloxacin between cows (percent bound: 59.4%) and steers (percent bound: 60.8%). Ciprofloxacin was more extensively bound to plasma proteins in steers (percent bound: 49.6%) than in cows (percent bound: 33.8%). The steady state volume of distribution of enrofloxacin is comparable in cows (1.55 L/kg) and steers (1.59 L/kg). Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. Ciprofloxacin was more concentrated in milk than enrofloxacin. JF - Research in Veterinary Science AU - Idowu, O R AU - Peggins, JO AU - Cullison, R AU - Von Bredow, J Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 230 EP - 235 PB - W.B. Saunders Co. Ltd., 32 Jamestown Rd London NW1 7BY UK VL - 89 IS - 2 SN - 0034-5288, 0034-5288 KW - Toxicology Abstracts KW - Enrofloxacin KW - Ciprofloxacin KW - Pharmacokinetics KW - Lactating cows KW - Steers KW - Plasma proteins KW - Intravenous administration KW - Dairies KW - Milk KW - Beef KW - Metabolites KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839678977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Veterinary+Science&rft.atitle=Comparative+pharmacokinetics+of+enrofloxacin+and+ciprofloxacin+in+lactating+dairy+cows+and+beef+steers+following+intravenous+administration+of+enrofloxacin&rft.au=Idowu%2C+O+R%3BPeggins%2C+JO%3BCullison%2C+R%3BVon+Bredow%2C+J&rft.aulast=Idowu&rft.aufirst=O&rft.date=2010-10-01&rft.volume=89&rft.issue=2&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Research+in+Veterinary+Science&rft.issn=00345288&rft_id=info:doi/10.1016%2Fj.rvsc.2009.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2014-09-05 N1 - SubjectsTermNotLitGenreText - Plasma proteins; Ciprofloxacin; Dairies; Intravenous administration; Milk; Enrofloxacin; Beef; Metabolites; Pharmacokinetics DO - http://dx.doi.org/10.1016/j.rvsc.2009.12.019 ER - TY - JOUR T1 - Evaluation of Guillain-Barre Syndrome Among Recipients of Influenza Vaccine in 2000 and 2001 AN - 822497509; 201031349 AB - The 1976-1977 swine influenza vaccine was associated with an elevated risk of Guillain-Barre Syndrome (GBS), especially within 6 weeks after vaccination. A 2004 IOM report concluded that evidence was inadequate to accept or reject a causal relationship between subsequent influenza vaccine formulations and GBS. Studies published after the IOM report have been limited by passively reported data or lack of validation of coded diagnoses. Objective: To evaluate whether influenza vaccine is associated with GBS. Methods: Controlled observational study using national data from the Medicare program, which ensures a predominantly elderly population. People included had a Medicare claim for influenza vaccination during September-December in 2000 or 2001. Medical records were reviewed to classify definite, probable, or possible GBS (or not a case) using a standardized case definition. In a risk interval design, the incidence rate of GBS during Weeks 0-6 after vaccination (exposed period) was compared to Weeks 9-14 after vaccination (comparison period). Data collection occurred during 2003-2007, and analysis was conducted during 2007-2009. Results: Primary analysis included 22.2 million vaccinees, among whom 164 definite or probable GBS cases with onset during Weeks 0-6 or 9-14 were identified. The incidence rate ratio (IRR [95% CIs]) based on the GBS rate in the vaccine-exposed versus comparison periods, was 1.04 (0.76, 1.43) for combined years; 0.86 (0.52, 1.41) among people vaccinated in 2000; and 1.21 (0.79, 1.86) among people vaccinated in 2001. Secondary analysis additionally included 74 possible GBS cases; results were similar. Conclusions: Overall, the results do not support an association between influenza vaccine receipt and GBS among the elderly for the years studied (2000-2001 and 2001-2002 formulations). [Copyright American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Burwen, Dale R AU - Ball, Robert AU - Bryan, Wilson W AU - Izurieta, Hector S AU - La Voie, Lawrence AU - Gibbs, Neville A AU - Kliman, Rebecca AU - Braun, M Miles AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland dale.burwen@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 296 EP - 304 PB - Elsevier Science, New York NY VL - 39 IS - 4 SN - 0749-3797, 0749-3797 KW - Influenza KW - Elderly people KW - Guillain-Barre syndrome KW - Medicare KW - Vaccines KW - Immunization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Evaluation+of+Guillain-Barre+Syndrome+Among+Recipients+of+Influenza+Vaccine+in+2000+and+2001&rft.au=Burwen%2C+Dale+R%3BBall%2C+Robert%3BBryan%2C+Wilson+W%3BIzurieta%2C+Hector+S%3BLa+Voie%2C+Lawrence%3BGibbs%2C+Neville+A%3BKliman%2C+Rebecca%3BBraun%2C+M+Miles&rft.aulast=Burwen&rft.aufirst=Dale&rft.date=2010-10-01&rft.volume=39&rft.issue=4&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2010.05.022 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Influenza; Vaccines; Immunization; Guillain-Barre syndrome; Medicare; Elderly people DO - http://dx.doi.org/10.1016/j.amepre.2010.05.022 ER - TY - JOUR T1 - Factors Associated with the Prevalence of Non-ROPS Tractors on Farms in the U.S. AN - 821736678; 14029798 AB - Rollover protective structures (ROPS) are an effective engineering control known to prevent tractor overturn deaths, the leading cause of occupational fatalities for farmers and farm workers in the U.S. However, the use of ROPS is known to vary greatly from farm to farm. A national sample of 11,458 farm operators from the 2004 Occupational Injury Surveillance of Production Agriculture (OISPA) survey was used to assess the association between the prevalence of ROPS and ten farm operator and farm demographic variables using logistic regression. The variable were: operator's age, operator's sex, operator's education, farm sales, full- or part-time farming, acreage, type of operation, number of hired workers, number of injuries, and region. All ten variables were found to have significant associations with the prevalence of non-ROPS tractors on farms in the univariate logistic regressions. For the multivariate model, all variables except for the sex of the farm operator remained significant. Farms with less than three adult injuries, no hired workers, less than 300 acres in size, a Midwest location, and a primary farm type of tobacco, fruit and nuts, dairy, or poultry and eggs all had adjusted odds ratios of 2 or greater. Increasing the prevalence of ROPS-equipped tractors is essential for reducing the leading cause of death on farms, tractor overturns. Economic factors play a major role in the prevalence and distribution of non-ROPS tractors on farms. The identified associations can be used to effectively target areas of the U.S. for ROPS promotion activities. JF - Journal of Agricultural Safety and Health AU - Myers, J R AD - Division of Safety Research, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA, jrmyers@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 265 EP - 278 VL - 16 IS - 4 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Education KW - Dairies KW - safety engineering KW - Injuries KW - farms KW - fruits KW - Tobacco KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821736678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Factors+Associated+with+the+Prevalence+of+Non-ROPS+Tractors+on+Farms+in+the+U.S.&rft.au=Myers%2C+J+R&rft.aulast=Myers&rft.aufirst=J&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Mortality; Dairies; Education; safety engineering; Injuries; farms; fruits; Tobacco; Agricultural equipment; USA ER - TY - JOUR T1 - Injury Surveillance for Youth on Farms in the U.S., 2006 AN - 821736131; 14029799 AB - In order to provide injury surveillance for youth on farms in the U.S., the National Institute for Occupational Safety and Health (NIOSH), in partnership with the USDA, developed the Childhood Agricultural Injury Survey (CAIS). CAIS data for all youth less than 20 years of age on farms have been collected for the calendar years of 1998, 2001, 2004, and 2006. CAIS data from 2006 indicated that an estimated 30.7 million youth lived on, worked on, or visited U.S. farms. These youth experienced almost 23,000 injuries while on the farm. The majority of these injuries occurred to males (15,223) and youth between the ages of 10 and 15 years (10,158). Approximately 25% (5,773) of the injuries were related to work being done on the farm. Youth living on the farm incurred 51% (11,654) of the injuries, hired youth sustained 6% (1,363), and 40% were to visiting youth (9,729). Although youth injuries on farms have declined by 30% since 1998, the numbers are still unacceptably high. Further indepth evaluation of subsets of the youth population may serve to better direct safety intervention programs and research. JF - Journal of Agricultural Safety and Health AU - Hendricks, K J AU - Goldcamp, E M AD - Division of Safety Research, National Institute for Occupational Safety and Health, M/S 1808, 1095 Willowdale Rd., Morgantown, WV 26505, USA, Khendricks@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 279 EP - 291 VL - 16 IS - 4 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - USA KW - Age KW - Injuries KW - farms KW - intervention KW - Occupational safety KW - Children KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821736131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Injury+Surveillance+for+Youth+on+Farms+in+the+U.S.%2C+2006&rft.au=Hendricks%2C+K+J%3BGoldcamp%2C+E+M&rft.aulast=Hendricks&rft.aufirst=K&rft.date=2010-10-01&rft.volume=16&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Age; Injuries; intervention; farms; Occupational safety; Children; USA ER - TY - JOUR T1 - Rising To The Challenge: Tools For Enrolling Eligible Children In Health Coverage AN - 818792638; 2010-643702 AB - Nearly five million uninsured children in the United States are currently eligible for Medicaid or the Children's Health Insurance Program (CHIP) but are not enrolled in these programs. A top Obama administration priority is to achieve the long-sought goal of ensuring that uninsured children are enrolled& that they stay enrolled for as long as they are eligible. The author, who is secretary of the U.S. Department of Health & Human Services (HHS), outlines measures that HHS & other federal agencies are implementing to reach this goal. She also cites existing state efforts to enroll more children & improve children's coverage, & she describes steps that states, local governments, & the private sector can take to expand outreach efforts, increase enrollment, & keep eligible children covered. Adapted from the source document. JF - Health Affairs AU - Sebelius, Kathleen AD - US Dept Health & Human Services, Washington, DC healthcare@hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1930 EP - 1932 PB - Project HOPE, Bethesda MD VL - 29 IS - 10 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Insurance KW - Government - Local and municipal government KW - Children's Health KW - Children KW - Obama, Barack KW - United States KW - Uninsured persons KW - Local government KW - Health insurance KW - Health policy KW - Child health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818792638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Rising+To+The+Challenge%3A+Tools+For+Enrolling+Eligible+Children+In+Health+Coverage&rft.au=Sebelius%2C+Kathleen&rft.aulast=Sebelius&rft.aufirst=Kathleen&rft.date=2010-10-01&rft.volume=29&rft.issue=10&rft.spage=1930&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0852 LA - English DB - PAIS Index N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Child health; Health insurance; Uninsured persons; United States; Health policy; Obama, Barack; Local government DO - http://dx.doi.org/10.1377/hlthaff.2010.0852 ER - TY - JOUR T1 - Endothelial Function, a Biomarker of Subclinical Cardiovascular Disease, in Urban Police Officers AN - 817611223; 13984197 AB - Objective: Police officers were hypothesized to have decreased endothelial function, measured by brachial artery flow-mediated dilation (FMD). Methods: We compared FMD in police officers (n = 261) and a population sample of men and women (n = 229), all from the same geographical region and free of clinical cardiovascular disease (CVD). Results: Compared with the population sample, police officers had significantly increased age-adjusted CVD risk factors (systolic and diastolic blood pressure, total cholesterol, smoking prevalence, and alcohol consumption). Police officers exhibited lower mean FMD after adjustment for age, gender, and traditional CVD risk factors among those aged 55 years or younger (%dilation: police = 5.49%, population = 6.49%; P = 0.04). Conclusions: Police officers exhibited decreased endothelial function (lower FMD) compared with the civilian sample, which was not fully explained by traditional CVD risk factors, suggesting that other pathways may contribute to increased CVD risk in law enforcement work. JF - Journal of Occupational and Environmental Medicine AU - Joseph, P N AU - Violanti, J M AU - Donahue, R AU - Andrew, ME AU - Trevisan, M AU - Burchfiel, C M AU - Dorn, J AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road M/S 4050, Morgantown, WV 26505, USA, nedrajoseph@hotmail.com Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 1004 EP - 1008 VL - 52 IS - 10 SN - 1076-2752, 1076-2752 KW - Risk Abstracts KW - Bioindicators KW - Alcohol KW - Age KW - blood pressure KW - cholesterol KW - police KW - Gender KW - law enforcement KW - Cardiovascular diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817611223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-11-01&rft.volume=&rft.issue=559&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; Alcohol; Age; police; blood pressure; Gender; law enforcement; Cardiovascular diseases; cholesterol DO - http://dx.doi.org/10.1097/JOM.0b013e3181f4385c ER - TY - JOUR T1 - Dissolution of cemented carbide powders in artificial sweat: implications for cobalt sensitization and contact dermatitis AN - 817610732; 13981733 AB - Skin exposure to cobalt-containing materials can cause systemic immune sensitization and upon repeat contact, elicitation of allergic contact dermatitis (ACD). Data on cobalt dissolution rates are needed to calculate uptake through skin and for development of models to understand risk of sensitization or dermatitis. The purpose of this research was to measure the dissolution kinetics of feedstock and process-sampled powders encountered in the production of hard metal alloys using artificial sweat. The physicochemical properties of each material were characterized prior to evaluation of dissolution behavior. Variations in artificial sweat solvent pH and chemistry were used to understand critical factors in dissolution. Dissolution of cobalt, tungsten, and tungsten carbide was often biphasic with the initial rapid phase being up to three orders of magnitude faster than the latter long-term phase. Artificial sweat pH did not influence dissolution of cobalt or tungsten carbide. Solvent composition had little influence on observed dissolution rates; however, vitamin E suppressed the dissolution of cobalt and tungsten carbide from sintered particles obtained from a chamfer grinder. There was no effect of particle size on dissolution of feedstock cobalt, tungsten, tungsten carbide, and admixture powders. Particle physicochemical properties influenced observed dissolution rates with more cobalt and tungsten carbide dissolving from chamfer grinder particles compared to the feedstock powders or admixture powder. Calculations using the observed dissolution rates revealed that skin exposure concentrations were similar to concentrations known to induce cobalt sensitization and elicit ACD. Observed dissolution rates for cobalt in artificial sweat indicate that dermal uptake may be sufficient to induce cobalt sensitization and allergic dermatitis. JF - Journal of Environmental Monitoring AU - Stefaniak, AB AU - Harvey, C J AU - Virji, MA AU - Day, G A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2800, Morgantown, WV, 26505, USA, AStefaniak@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1815 EP - 1822 VL - 12 IS - 10 SN - 1464-0325, 1464-0325 KW - Risk Abstracts; Environment Abstracts; Pollution Abstracts KW - Metals KW - Skin KW - Contact dermatitis KW - Cobalt KW - contact dermatitis KW - Physicochemical properties KW - Solvents KW - Particulates KW - pH KW - Tungsten KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/817610732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Dissolution+of+cemented+carbide+powders+in+artificial+sweat%3A+implications+for+cobalt+sensitization+and+contact+dermatitis&rft.au=Stefaniak%2C+AB%3BHarvey%2C+C+J%3BVirji%2C+MA%3BDay%2C+G+A&rft.aulast=Stefaniak&rft.aufirst=AB&rft.date=2010-10-01&rft.volume=12&rft.issue=10&rft.spage=1815&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fc0em00269k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Metals; Contact dermatitis; Skin; contact dermatitis; Cobalt; Physicochemical properties; Solvents; Particulates; pH; Tungsten DO - http://dx.doi.org/10.1039/c0em00269k ER - TY - JOUR T1 - Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entities AN - 815538440; 13869019 AB - Bioterrorism poses a daunting challenge to global security and public health in the 21st century. Variola major virus, the etiological agent of smallpox, and Bacillus anthracis, the bacterial pathogen responsible for anthrax, remain at the apex of potential pathogens that could be used in a bioterror attack to inflict mass casualties. Although licensed vaccines are available for both smallpox and anthrax, because of inadequacies associated with each of these vaccines, serious concerns remain as to the deployability of these vaccines, especially in the aftermath of a bioterror attack involving these pathogens. We have developed a single vaccine (Wyeth/IL-15/PA) using the licensed Wyeth smallpox vaccine strain that is efficacious against both smallpox and anthrax due to the integration of immune-enhancing cytokine IL-15 and the protective antigen (PA) of B. anthracis into the Wyeth vaccinia virus. Integration of IL-15 renders Wyeth vaccinia avirulent in immunodeficient mice and enhances anti-vaccinia immune responses. Wyeth/IL-15/PA conferred sterile protection against a lethal challenge of B. anthracis Ames strain spores in rabbits. A single dose of Wyeth/IL-15/PA protected 33% of the vaccinated A/J mice against a lethal spore challenge 72 h later whereas a single dose of licensed anthrax vaccine protected only 10%. Our dual vaccine Wyeth/IL-15/PA remedies the inadequacies associated with the licensed vaccines, and the inherent ability of Wyeth vaccinia virus to be lyophilized without loss of potency makes it cold-chain independent, thus simplifying the logistics of storage, stockpiling, and field delivery in the event of a bioterror attack involving smallpox or anthrax. JF - Proceedings of the National Academy of Sciences, USA AU - Merkel, Tod J AU - Perera, Pin-Yu AU - Kelly, Vanessa K AU - Verma, Anita AU - Llewellyn, Zara N AU - Waldmann, Thomas A AU - Mosca, Joseph D AU - Perera, Liyanage P AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 18091 EP - 18096 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 107 IS - 42 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Virology & AIDS Abstracts; Toxicology Abstracts KW - Anthrax KW - Immune response KW - Immunodeficiency KW - Integration KW - Interleukin 15 KW - Pathogens KW - Public health KW - Smallpox KW - Spores KW - Vaccines KW - Vaccinia KW - bioterrorism KW - protective antigen KW - Bacillus anthracis KW - Vaccinia virus KW - Variola KW - F 06905:Vaccines KW - V 22350:Immunology KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815538440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Development+of+a+highly+efficacious+vaccinia-based+dual+vaccine+against+smallpox+and+anthrax%2C+two+important+bioterror+entities&rft.au=Merkel%2C+Tod+J%3BPerera%2C+Pin-Yu%3BKelly%2C+Vanessa+K%3BVerma%2C+Anita%3BLlewellyn%2C+Zara+N%3BWaldmann%2C+Thomas+A%3BMosca%2C+Joseph+D%3BPerera%2C+Liyanage+P&rft.aulast=Merkel&rft.aufirst=Tod&rft.date=2010-10-01&rft.volume=107&rft.issue=42&rft.spage=18091&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1013083107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - bioterrorism; Vaccinia; protective antigen; Immunodeficiency; Pathogens; Public health; Smallpox; Integration; Interleukin 15; Anthrax; Vaccines; Immune response; Spores; Vaccinia virus; Variola; Bacillus anthracis DO - http://dx.doi.org/10.1073/pnas.1013083107 ER - TY - JOUR T1 - Development of Human-Murine Chimeric Immunoglobulin G for Use in the Serological Detection of Human Flavivirus and Alphavirus Antibodies AN - 815536601; 13810841 AB - Diagnosis of human arboviral infections relies heavily on serological techniques such as the immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay (MAC-ELISA) and the indirect IgG ELISA. Broad application of these assays is hindered by the lack of standardized positive human control sera that react with a wide variety of flaviviruses (e.g., dengue, West Nile, yellow fever, Japanese encephalitis, Saint Louis encephalitis, and Powassan viruses), or alphaviruses (e.g., Eastern equine encephalitis, Western equine encephalitis, Venezuelan equine encephalitis, and chikungunya viruses) that can cause human disease. We have created human-murine chimeric monoclonal antibodies (cMAbs) by combining the variable regions of flavivirus (6B6C-1) or alphavirus (1A4B-6) broadly cross-reactive murine MAbs (mMAbs) with the constant region of human IgG1. These cMAbs may be used as standardized reagents capable of replacing human infection-immune-positive control sera in indirect IgG ELISA for diagnosis of all human flaviviral or alphaviral infections. The IgG cMAbs secreted from plasmid-transformed Sp2/0-Ag14 cells had serological activity identical to that of the parent mMAbs, as measured by ELISA using multiple flaviviruses or alphaviruses. JF - Clinical and Vaccine Immunology AU - Thibodeaux, Brett A AU - Panella, Amanda N AU - Roehrig, John T AD - Arboviral Diseases Branch, Division of Vector-Borne Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, 3150 Rampart Road, Fort Collins, Colorado 80521, epx1@cdc.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1617 EP - 1623 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 10 SN - 1556-6811, 1556-6811 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Immunology Abstracts KW - Human diseases KW - Viruses KW - Disease control KW - Infection KW - Flavivirus KW - Public health KW - Constant region KW - Dengue KW - Senegal, Saint Louis KW - Yellow fever KW - ELISA KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Immunology KW - Venezuelan equine encephalitis KW - Encephalitis KW - Western equine encephalitis KW - Antibodies KW - Immunoglobulin G KW - Eastern equine encephalitis KW - Alphavirus KW - Vaccines KW - Immunoglobulin M KW - Variable region KW - F 06905:Vaccines KW - V 22300:Methods KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/815536601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+of+Human-Murine+Chimeric+Immunoglobulin+G+for+Use+in+the+Serological+Detection+of+Human+Flavivirus+and+Alphavirus+Antibodies&rft.au=Thibodeaux%2C+Brett+A%3BPanella%2C+Amanda+N%3BRoehrig%2C+John+T&rft.aulast=Thibodeaux&rft.aufirst=Brett&rft.date=2010-10-01&rft.volume=17&rft.issue=10&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00097-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 33 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Human diseases; Antibodies; Monoclonal antibodies; Immunology; Viruses; Disease control; ELISA; Vaccines; Public health; Enzyme-linked immunosorbent assay; Venezuelan equine encephalitis; Infection; Encephalitis; Western equine encephalitis; Constant region; Dengue; Yellow fever; Immunoglobulin G; Eastern equine encephalitis; Immunoglobulin M; Variable region; Alphavirus; Flavivirus; Senegal, Saint Louis DO - http://dx.doi.org/10.1128/CVI.00097-10 ER - TY - JOUR T1 - Renal crystal formation after combined or sequential oral administration of melamine and cyanuric acid AN - 787260469; 13680778 AB - We evaluated renal melamine-cyanurate crystal spherulite formation after single and repeated ingestion of both melamine (MEL) and cyanuric acid (CYA) in catfish and trout. MEL and CYA were co-administered orally over a range of doses, 0.1-20mg/kg body weight (bw) of each compound, either once or repeatedly for 4, 14 or 28days (d). In catfish, the No Observable Adverse Effects Levels (NOAELs) for crystal formation for single, 4d or 14d dosing were 10, 2.5 and 0.5mg/kgbw, respectively. In trout, the respective NOAELs were 2.5, 2.5 and 0.5mg/kgbw. No renal crystals formed in catfish fed 0.1mg/kgbw of each compound for 28d. Sequential administration of 20mg/kgbw of MEL followed by 20mg/kgbw of CYA or vise-versa, with waiting periods of 1, 3, 7, 14 or 21d between compound dosing also induced renal crystal formation in fish. These studies show that both catfish and trout are sensitive, non-mammalian models, for renal crystal formation following MEL and CYA ingestion. Since fish generally excrete chemicals more slowly than mammals, they may provide a "worst case scenario" model for higher risk populations, such as infants or persons with compromised renal function. JF - Food and Chemical Toxicology AU - Reimschuessel, R AU - Evans, E R AU - Stine, C B AU - Hasbrouck, N AU - Mayer, T D AU - Nochetto, C AU - Gieseker, C M AD - Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd., Laurel, MD 20708, USA, Renate.reimschuessel@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 2898 EP - 2906 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 48 IS - 10 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Bw KW - C KW - cm KW - CVM KW - CYA KW - d KW - DO KW - g KW - GLP KW - K el KW - L KW - LC-MS/MS KW - LOQ KW - MEL KW - mg/kg KW - min KW - mL KW - mM KW - N KW - NOAEL KW - ppm KW - s KW - S.D KW - t 1/2 KW - TDI KW - USFDA KW - VOCs KW - I14g/mL KW - I14m KW - Melamine KW - Cyanuric acid KW - Kidney KW - Crystal KW - No observable adverse effect level KW - Fish KW - Renal function KW - Body weight KW - Risk factors KW - spherulites KW - Oral administration KW - Crystals KW - Side effects KW - Models KW - Infants KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787260469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Renal+crystal+formation+after+combined+or+sequential+oral+administration+of+melamine+and+cyanuric+acid&rft.au=Reimschuessel%2C+R%3BEvans%2C+E+R%3BStine%2C+C+B%3BHasbrouck%2C+N%3BMayer%2C+T+D%3BNochetto%2C+C%3BGieseker%2C+C+M&rft.aulast=Reimschuessel&rft.aufirst=R&rft.date=2010-10-01&rft.volume=48&rft.issue=10&rft.spage=2898&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2010.07.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Body weight; Renal function; Risk factors; spherulites; Oral administration; Cyanuric acid; Crystals; Side effects; Infants; Models DO - http://dx.doi.org/10.1016/j.fct.2010.07.024 ER - TY - JOUR T1 - Categorizing Temporal Patterns of Arrest in a Cohort of Adults with Serious Mental Illness AN - 772256251; 201029978 AB - Temporal patterns of arrest among mental health systems' clientele have not been well explored. This study uses "trajectory analysis," a methodology widely employed by criminologists exploring patterns of desistence in offending, to examine patterns of criminal justice involvement in a cohort of mental health service recipients. Data for this study are from a statewide cohort of individuals who received services from the Massachusetts Department of Mental Health in 1991 (N?=?13,876) and whose arrests were followed for roughly 10 years. Zero-inflated Poisson trajectory analysis applied to cohort members having two or more arrests identified five trajectories with widely varying arrest patterns. Analysis of differences in the composition of the five trajectory-based groups revealed few between-group differences in members' demographic and service use characteristics, while certain offense types were disproportionately prevalent among particular trajectory-based groups. The implications of these findings for understanding criminal justice involvement in this population and the utility of the trajectory model for system planning are discussed. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Fisher, William H AU - Banks, Steven M AU - Roy-Bujnowski, Kristen AU - Grudzinskas, Albert J AU - Simon, Lorna J AU - Wolff, Nancy AD - Center for Mental Health Services Research, Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 bill.fisher@umassmed.edu Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 477 EP - 490 PB - Springer, US VL - 37 IS - 4 SN - 1094-3412, 1094-3412 KW - criminal justice involvement serious mental illness trajectory analysis KW - Mentally ill people KW - Criminal justice KW - Temporal patterns KW - Mental health KW - Arrests KW - Demographic aspects KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772256251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Mechanisms+and+Methods&rft.atitle=Partition+coefficients+for+nonane+and+its+isomers+in+the+rat&rft.au=Joshi%2C+G%3BTremblay%2C+R+T%3BMartin%2C+SA%3BFisher%2C+J+W&rft.aulast=Joshi&rft.aufirst=G&rft.date=2010-11-01&rft.volume=20&rft.issue=9&rft.spage=594&rft.isbn=&rft.btitle=&rft.title=Toxicology+Mechanisms+and+Methods&rft.issn=15376516&rft_id=info:doi/10.3109%2F15376516.2010.518175 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Arrests; Criminal justice; Mental health; Temporal patterns; Mentally ill people; Demographic aspects DO - http://dx.doi.org/10.1007/s11414-009-9188-9 ER - TY - JOUR T1 - Detection of Target Staphylococcal Enterotoxin B Antigen in Orange Juice and Popular Carbonated Beverages Using Antibody-Dependent Antigen-Capture Assays AN - 762271853; 13817336 AB - Abstract: There is a critical need for qualitative and quantitative methodologies that provide the rapid and accurate detection of food contaminants in complex food matrices. However, the sensitivity of the assay can be affected when antigen-capture is applied to certain foods or beverages that are extremely acidic. This study was undertaken to assess the effects of orange juice and popular carbonated soft drink upon the fidelity of antibody-based antigen-capture assays and to develop simple approaches that could rescue assay performance without the introduction of additional or extensive extraction procedures. We examined the effects of orange juice and a variety of popular carbonated soft drink beverages upon a quantitative Interleukin-2 (IL-2) enzyme-linked immunosorbent assay (ELISA) assay system and a lateral flow device (LFD) adapted for the detection of staphylococcal enterotoxin B (SEB) in foods. Alterations in the performance and sensitivity of the assay were directly attributable to the food matrix, and alterations in pH were especially critical. The results demonstrate that approaches such as an alteration of pH and the use of milk as a blocking agent, either singly or in combination, will partially rescue ELISA performance. The same approaches permit lateral flow to efficiently detect antigen. Practical Application: The authors present ways to rescue an ELISA assay compromised by acidity in beverages and show that either the alteration of pH, or the use of milk as a blocking agent are not always capable of restoring the assay to its intended efficiency. However, the same methods, when employed with lateral flow technology, are rapid and extremely successful. JF - Journal of Food Science AU - Principato, MaryAnn AU - Njoroge, Joyce M AU - Perlloni, Andrei AU - Donnell, Michael O' AU - Boyle, Thomas AU - Jones, Jr Robert L AD - 1Authors Principato, Njoroge, and Jones, Jr. are with the U.S. Food and Drug Administration, CFSAN 8301 Muirkirk Rd., Laurel, MD 20708, U.S.A. Author O'uDonnell is with U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20708, U.S.A. Author Perlloni is with U.S. Food and Drug Administration, Office Emergency Operations 5600 Fishers Lane, Rockville, Md. 20857, U.S.A. Previous address of authors Perlloni and Boyle is 8301 Muirkirk Rd., Laurel, MD, U.S.A. Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - T141 EP - T147 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 75 IS - 8 SN - 0022-1147, 0022-1147 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - carbonated beverages KW - ELISA KW - lateral flow detector KW - orange juice KW - SEB KW - Citrus KW - Sensitivity KW - Enzyme-linked immunosorbent assay KW - Beverages KW - Milk KW - Interleukin 2 KW - Assays KW - Carbonated beverages KW - Food contamination KW - Staphylococcal enterotoxin B KW - Fruit juices KW - Fidelity KW - Immunoassays KW - pH effects KW - pH KW - J 02330:Biochemistry KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762271853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Detection+of+Target+Staphylococcal+Enterotoxin+B+Antigen+in+Orange+Juice+and+Popular+Carbonated+Beverages+Using+Antibody-Dependent+Antigen-Capture+Assays&rft.au=Principato%2C+MaryAnn%3BNjoroge%2C+Joyce+M%3BPerlloni%2C+Andrei%3BDonnell%2C+Michael+O%27%3BBoyle%2C+Thomas%3BJones%2C+Jr+Robert+L&rft.aulast=Principato&rft.aufirst=MaryAnn&rft.date=2010-10-01&rft.volume=75&rft.issue=8&rft.spage=T141&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2Fj.1750-3841.2010.01806.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 27 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Fruit juices; Fidelity; Enzyme-linked immunosorbent assay; Milk; Beverages; Interleukin 2; Carbonated beverages; Staphylococcal enterotoxin B; Food contamination; pH effects; Sensitivity; Assays; Immunoassays; pH; Citrus DO - http://dx.doi.org/10.1111/j.1750-3841.2010.01806.x ER - TY - JOUR T1 - Understanding Community Policing as an Innovation: Patterns of Adoption AN - 758129821; 201059603 AB - In the 1980s and 1990s, community policing was viewed by many as a radical innovation in the field of policing, with the vast majority of police agencies reporting to have adopted the approach. Despite its overwhelming popularity, most police agencies did not adopt the central elements of community policing. This study examines patterns of community policing adoption of 474 police departments across the United States. Using an innovations framework, a model was developed that measures the extent to which community characteristics, organizational complexity, and organizational commitment can explain differences in the adoption of community policing. Findings suggest that the innovations approach can explain some variation in the adoption of community policing and should be considered in future police research. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Crime & Delinquency AU - Schaefer Morabito, Melissa AD - Center for Mental Health Services & Criminal Justice Research New Brunswick, New Jersey Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 564 EP - 587 PB - Sage Publications, Thousand Oaks CA VL - 56 IS - 4 SN - 0011-1287, 0011-1287 KW - community policing innovations adoption KW - Socioeconomic Factors KW - Organizational Commitment KW - Methodology (Data Collection) KW - Investigations (Law Enforcement) KW - United States of America KW - Police KW - Adoption of Innovations KW - Innovations KW - article KW - 2151: social problems and social welfare; juvenile delinquency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758129821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Crime+%26+Delinquency&rft.atitle=Understanding+Community+Policing+as+an+Innovation%3A+Patterns+of+Adoption&rft.au=Schaefer+Morabito%2C+Melissa&rft.aulast=Schaefer+Morabito&rft.aufirst=Melissa&rft.date=2010-10-01&rft.volume=56&rft.issue=4&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Crime+%26+Delinquency&rft.issn=00111287&rft_id=info:doi/10.1177%2F0011128707311643 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 49 N1 - Last updated - 2016-09-28 N1 - CODEN - CRDLAL N1 - SubjectsTermNotLitGenreText - Investigations (Law Enforcement); Police; Adoption of Innovations; Innovations; United States of America; Methodology (Data Collection); Organizational Commitment; Socioeconomic Factors DO - http://dx.doi.org/10.1177/0011128707311643 ER - TY - JOUR T1 - Improving proton MR spectroscopy of brain tissue for noninvasive diagnostics. AN - 756298596; 20882612 AB - To examine preprocessing methods affecting the potential use of Magnetic Resonance Spectroscopy (MRS) as a noninvasive modality for detection and characterization of brain lesions and for directing therapy progress. Two reference point re-calibration with linear interpolation (to compensate for magnetic field nonhomogeneity), weighting of spectra (to emphasize consistent peaks and depress chemical noise), and modeling based on chemical shift locations of 97 biomarkers were investigated. Results for 139 categorized scans were assessed by comparing Leave-One-Out (LOO) cross-validation and external validation. For distinction of nine brain tissue categories, use of re-calibration, variance weighting, and biomarker modeling improved LOO classification of MRS spectra from 31% to 95%. External validation of the two best nine-category models on 47 unknown samples gave 96% or 100% accuracy, respectively, compared with pathological diagnosis. Preprocessing of MRS spectra can significantly improve their diagnostic utility for automated consultation of pattern recognition models. Use of several techniques in combination greatly increases available proton MRS information content. Accurate assignment of unknowns among nine tissue classes represents a significant improvement, for a much more demanding task, than has been previously reported. JF - Journal of magnetic resonance imaging : JMRI AU - Alusta, Pierre AU - Im, Inessa AU - Pearce, Bruce A AU - Beger, Richard D AU - Kretzer, Ryan M AU - Buzatu, Dan A AU - Wilkes, Jon G AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas 72079, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 818 EP - 829 VL - 32 IS - 4 KW - Biomarkers KW - 0 KW - Protons KW - Index Medicus KW - Biomarkers -- chemistry KW - Brain Mapping -- methods KW - Reproducibility of Results KW - Humans KW - Brain -- pathology KW - Calibration KW - Automatic Data Processing KW - Pattern Recognition, Automated KW - Image Processing, Computer-Assisted KW - Brain Neoplasms -- pathology KW - Magnetic Resonance Spectroscopy -- methods KW - Medical Oncology -- methods KW - Brain Neoplasms -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756298596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.atitle=Improving+proton+MR+spectroscopy+of+brain+tissue+for+noninvasive+diagnostics.&rft.au=Alusta%2C+Pierre%3BIm%2C+Inessa%3BPearce%2C+Bruce+A%3BBeger%2C+Richard+D%3BKretzer%2C+Ryan+M%3BBuzatu%2C+Dan+A%3BWilkes%2C+Jon+G&rft.aulast=Alusta&rft.aufirst=Pierre&rft.date=2010-10-01&rft.volume=32&rft.issue=4&rft.spage=818&rft.isbn=&rft.btitle=&rft.title=Journal+of+magnetic+resonance+imaging+%3A+JMRI&rft.issn=1522-2586&rft_id=info:doi/10.1002%2Fjmri.22332 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-02 N1 - Date created - 2010-09-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jmri.22332 ER - TY - JOUR T1 - Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. AN - 755970637; 20548288 AB - The importance of dysregulation of microRNA (miRNA) expression in nonalcoholic steatohepatitis (NASH) has been increasingly recognized; however, the association between altered expression of miRNAs and pathophysiological features of NASH and whether there is a connection between susceptibility to NASH and altered expression of miRNAs are largely unknown. In this study, male inbred C57BL/6J and DBA/2J mice were fed a lipogenic methyl-deficient diet that causes liver injury similar to human NASH, and the expression of miRNAs and the level of proteins targeted by these miRNAs in the livers were determined. Administration of the methyl-deficient diet triggered NASH-specific changes in the livers of C57BL/6J and DBA/2J mice, with the magnitude being more severe in DBA/2J mice. This was evidenced by a greater extent of expression of fibrosis-related genes in the livers of methyl-deficient DBA/2J mice. The development of NASH was accompanied by prominent changes in the expression of miRNAs, including miR-29c, miR-34a, miR-155, and miR-200b. Interestingly, changes in the expression of these miRNAs and protein levels of their targets, including Cebp-β, Socs 1, Zeb-1, and E-cadherin, in the livers of DBA/2J mice fed a methyl-deficient diet were more pronounced as compared with those in C57BL/6J mice. These results show that alterations in the expression of miRNAs are a prominent event during development of NASH induced by methyl deficiency and strongly suggest that severity of NASH and susceptibility to NASH may be determined by variations in miRNA expression response. More important, our data provide a mechanistic link between alterations in miRNA expression and pathophysiological and pathomorphological features of NASH. JF - Laboratory investigation; a journal of technical methods and pathology AU - Pogribny, Igor P AU - Starlard-Davenport, Athena AU - Tryndyak, Volodymyr P AU - Han, Tao AU - Ross, Sharon A AU - Rusyn, Ivan AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. igor.pogribny@fda.hhs.gov Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 1437 EP - 1446 VL - 90 IS - 10 KW - MIRN29 microRNA, mouse KW - 0 KW - MicroRNAs KW - Mirn134 microRNA, mouse KW - Mirn155 microRNA, mouse KW - Mirn200 microRNA, mouse KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Gene Expression Regulation KW - Chronic Disease KW - Diet KW - Lipogenesis KW - Species Specificity KW - Male KW - Mice, Inbred DBA KW - Liver -- pathology KW - Fatty Liver -- chemically induced KW - Disease Susceptibility KW - MicroRNAs -- genetics KW - MicroRNAs -- biosynthesis KW - Liver -- metabolism KW - Fatty Liver -- genetics KW - Fatty Liver -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755970637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Difference+in+expression+of+hepatic+microRNAs+miR-29c%2C+miR-34a%2C+miR-155%2C+and+miR-200b+is+associated+with+strain-specific+susceptibility+to+dietary+nonalcoholic+steatohepatitis+in+mice.&rft.au=Pogribny%2C+Igor+P%3BStarlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BRoss%2C+Sharon+A%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2010-10-01&rft.volume=90&rft.issue=10&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=1530-0307&rft_id=info:doi/10.1038%2Flabinvest.2010.113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-20 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/labinvest.2010.113 ER - TY - JOUR T1 - Phenotypic and genotypic characterization of tetracycline and minocycline resistance in Clostridium perfringens. AN - 755159680; 20661548 AB - The aim of this study was to determine the incidence of tetracycline resistance and the prevalence of tetracycline-resistance genes in strains of Clostridium perfringens isolated from different sources between 1994 and 2005. Susceptibility to tetracycline and minocycline in strains from humans (35 isolates), chickens (15 isolates), food (21 isolates), soil (16 isolates) and veterinary sources (6 isolates) was determined, and tetracycline-resistance genes were detected. Resistance was most common in strains isolated from chickens, followed by those from soils, clinical samples and foods. The most highly resistant strains were found among clinical and food isolates. tetA(P) was the most common resistance gene, and along with tetB(P) was found in all resistant strains and some sensitive strains. One tetracycline-resistant food isolate had an intact tet(M) gene. However, PCR fragments of 0.4 or 0.8 kb with high degrees of identity to parts of the tet(M) sequences of other bacteria were found, mainly in clinical isolates, and often in isolates with tetB(P). No correlation between level of sensitivity to tetracycline or minocycline and the presence of tetA(P), tetB(P) or part of tet(M) was found. The presence of part of tet(M) in some strains of C. perfringens containing tetB(P) may have occurred by recent gene transfer. JF - Archives of microbiology AU - Park, Miseon AU - Rooney, Alejandro P AU - Hecht, David W AU - Li, Jihong AU - McClane, Bruce A AU - Nayak, Rajesh AU - Paine, Donald D AU - Rafii, Fatemeh AD - National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2010/10// PY - 2010 DA - October 2010 SP - 803 EP - 810 VL - 192 IS - 10 KW - Anti-Bacterial Agents KW - 0 KW - Antiporters KW - Bacterial Proteins KW - TETP protein, Clostridium perfringens KW - tetA protein, Bacteria KW - Tetracycline KW - F8VB5M810T KW - Minocycline KW - FYY3R43WGO KW - Index Medicus KW - Animals KW - Genes, Bacterial KW - Bacterial Proteins -- genetics KW - Humans KW - Antiporters -- genetics KW - Microbial Sensitivity Tests KW - Tetracycline Resistance -- genetics KW - Minocycline -- pharmacology KW - Clostridium perfringens -- genetics KW - Clostridium perfringens -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Tetracycline -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755159680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+microbiology&rft.atitle=Phenotypic+and+genotypic+characterization+of+tetracycline+and+minocycline+resistance+in+Clostridium+perfringens.&rft.au=Park%2C+Miseon%3BRooney%2C+Alejandro+P%3BHecht%2C+David+W%3BLi%2C+Jihong%3BMcClane%2C+Bruce+A%3BNayak%2C+Rajesh%3BPaine%2C+Donald+D%3BRafii%2C+Fatemeh&rft.aulast=Park&rft.aufirst=Miseon&rft.date=2010-10-01&rft.volume=192&rft.issue=10&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Archives+of+microbiology&rft.issn=1432-072X&rft_id=info:doi/10.1007%2Fs00203-010-0605-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-30 N1 - Date created - 2010-09-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00203-010-0605-5 ER - TY - JOUR T1 - Oncomutations as biomarkers of cancer risk AN - 1034809974; 15033743 AB - Cancer risk assessment impacts a range of societal needs, from the regulation of chemicals to achieving the best possible human health outcomes. Because oncogene and tumor suppressor gene mutations are necessary for the development of cancer, such mutations are ideal biomarkers to use in cancer risk assessment. Consequently, DNA-based methods to quantify particular tumor-associated hotspot point mutations (i.e., oncomutations) have been developed, including allele-specific competitive blocker-PCR (ACB-PCR). Several studies using ACB-PCR and model mutagens have demonstrated that significant induction of tumor-associated oncomutations are measureable at earlier time points than are used to score tumors in a bioassay. In the particular case of benzo[a]pyrene induction of K-Ras codon 12 TGT mutation in the A/J mouse lung, measurement of tumor-associated oncomutation was shown to be an earlier and more sensitive endpoint than tumor response. The measurement of oncomutation by ACB-PCR led to two unexpected findings. First, oncomutations are present in various tissues of control rodents and 'normal' human colonic mucosa samples at relatively high frequencies. Approximately 60% of such samples (88/146) have mutant fractions (MFs) >10-5, and some have MFs as high as 10-3 or 10-4. Second, preliminary data indicate that oncomutations are present frequently as subpopulations in tumors. These findings are integrated into a hypothesis that the predominant preexisting mutations in particular tissues may be useful as generic reporters of carcinogenesis. Future research opportunities using oncomutation as an endpoint are described, including rodent to human extrapolation, dose-response assessment, and personalized medicine. Environ. Mol. Mutagen., 2010. Published 2010 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Parsons, Barbara L AU - Myers, Meagan B AU - Meng, Fanxue AU - Wang, Yiying AU - McKinzie, Page B Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 836 EP - 850 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 8-9 SN - 0893-6692, 0893-6692 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Bioindicators KW - Risk assessment KW - Chemicals KW - Mutagens KW - Hot spots KW - Tumors KW - Mutation KW - Cancer KW - Rodents KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1034809974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Oncomutations+as+biomarkers+of+cancer+risk&rft.au=Parsons%2C+Barbara+L%3BMyers%2C+Meagan+B%3BMeng%2C+Fanxue%3BWang%2C+Yiying%3BMcKinzie%2C+Page+B&rft.aulast=Parsons&rft.aufirst=Barbara&rft.date=2010-10-01&rft.volume=51&rft.issue=8-9&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20600 L2 - http://onlinelibrary.wiley.com/doi/10.1002/em.20600/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Chemicals; Risk assessment; Bioindicators; Mutagens; Hot spots; Tumors; Mutation; Rodents; Cancer DO - http://dx.doi.org/10.1002/em.20600 ER - TY - JOUR T1 - Improving the quality of industry and occupation data at a central cancer registry AN - 1017967097; 16691627 AB - Background Central cancer registries are required to collect industry and occupation (I/O) information when available, but the data reported are often incomplete. Methods We audited the completeness of I/O data in the New Hampshire State Cancer Registry (NHSCR) database for diagnosis year 2005, and reviewed medical records for a convenience sample of 474 of these cases. We compared I/O data quality before and after a statewide registrar training session on occupationally related cancers. Results The original 2005 data contained both I/O data in 11.5% of cases, and lacked any I/O data in 74.5%. Corresponding figures for cases selected for audit were 15.2% and 77.2%, which improved to 54.2% and 11.8% after medical record review. After registrar training, 47% of reports contained both I/O data, and only 14.4% of cases lacked any I/O data. Conclusions Statewide training to highlight the importance of I/O data is an effective method to improve I/O data quality. Am. J. Ind. Med. 53:995-1001, 2010. ? 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Armenti, Karla R AU - Celaya, Maria O AU - Cherala, Sai AU - Riddle, Bruce AU - Schumacher, Pamela K AU - Rees, Judy R AD - New Hampshire Department of Health and Human Services, Division of Public Health Services, Office of Health Statistics and Data Management, Concord, New Hampshire, karmenti@dhhs.state.nh.us Y1 - 2010/10// PY - 2010 DA - Oct 2010 SP - 995 EP - 1001 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 10 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - Training KW - Reviews KW - USA, New Hampshire KW - Cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017967097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Improving+the+quality+of+industry+and+occupation+data+at+a+central+cancer+registry&rft.au=Armenti%2C+Karla+R%3BCelaya%2C+Maria+O%3BCherala%2C+Sai%3BRiddle%2C+Bruce%3BSchumacher%2C+Pamela+K%3BRees%2C+Judy+R&rft.aulast=Armenti&rft.aufirst=Karla&rft.date=2010-10-01&rft.volume=53&rft.issue=10&rft.spage=995&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20851 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20851/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Training; Reviews; Cancer; USA, New Hampshire DO - http://dx.doi.org/10.1002/ajim.20851 ER - TY - JOUR T1 - Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy AN - 762280038; 13762424 AB - Background:It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC. Methods:Using population-based data, we calculated BC risk following HL according to clinicopathologic features. Results:Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC. Conclusion:Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors. JF - British Journal of Cancer AU - Dores, G M AU - Anderson, W F AU - Beane Freeman, L E AU - Fraumeni, J F AU - Curtis, R E AD - [1] Medical Service, Department of Veterans Affairs Medical Center, 921 N.E. 13th Street, Oklahoma City, OK 73104, USA [2] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Bethesda, MD 20892, USA Y1 - 2010/09/28/ PY - 2010 DA - 2010 Sep 28 SP - 1081 EP - 1084 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 103 IS - 7 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - Risk assessment KW - Progesterone receptors KW - Hodgkin's disease KW - Data processing KW - Radiotherapy KW - Breast cancer KW - lymphoma KW - radiotherapy KW - Estrogen receptors KW - Cancer KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762280038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+breast+cancer+according+to+clinicopathologic+features+among+long-term+survivors+of+Hodgkin%27s+lymphoma+treated+with+radiotherapy&rft.au=Dores%2C+G+M%3BAnderson%2C+W+F%3BBeane+Freeman%2C+L+E%3BFraumeni%2C+J+F%3BCurtis%2C+R+E&rft.aulast=Dores&rft.aufirst=G&rft.date=2010-09-28&rft.volume=103&rft.issue=7&rft.spage=1081&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6605877 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Progesterone receptors; Data processing; Hodgkin's disease; Breast cancer; Radiotherapy; Estrogen receptors; radiotherapy; lymphoma; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6605877 ER - TY - JOUR T1 - Kainic acid and 3-Nitropropionic acid induced expression of laminin in vascular elements of the rat brain. AN - 748971393; 20624377 AB - Laminin is a glycoprotein component of the basement membrane and has been reported to be found in different areas of the nervous system including brain endothelial cells, Schwann cells and peripheral nerves. Although the in-vitro studies suggest that laminin plays an important role in growth and neurite extension of cultured neurons, localization of laminin in the brain has been controversial and inconsistent results have been reported. Recently, laminin immunoreactivity has been used as a marker for vascular elements in the brain. In this study, we have investigated the effect of two mechanistically different neurotoxins, kainic acid (KA), an NMDA agonist and 3-Nitropropionic acid (3-NPA), an inhibitor of mitochondrial respiration, on brain vascular elements revealed by laminin immunolabeling. We also explored whether administration of these two neurotoxic drugs correlate with the neuronal degeneration observed after neurotoxic insult by staining with Fluoro-Jade C dye. We have employed single immunolabeling to localize laminin in the brains. In KA treated rats, most of the laminin immunoreactivity is present in the piriform cortex, corpus callosum (myelinated tracts) amygdala, hippocampus, ventral thalamus and tenia tacta. In 3-NPA treated animals, laminin immunoreactivity was confined mostly to the striatum. In contrast, saline treated rats showed very little laminin immunolabeling around capillaries, arteries and in the meningeal membranes. To determine the effects of these neurotoxins on the integrity of the blood brain barrier (BBB), endothelial brain barrier antigen (EBA) immunolabeling was also performed. In addition, we performed CD11b immunolabeling to evaluate the effect of 3-NPA and KA on the activation of microglia in the brain. CD11b was dramatically increased in KA and 3-NPA treated animals. We have also combined laminin immunolabeling with Fluoro-Jade C labeling to evaluate the spatio-temporal association of degenerating neurons and the expression of laminin containing microvessels. Areas which showed intense laminin immunolabeling following KA or 3-NPA exposure correlated with those exhibiting the greatest number of degenerating neurons observed after Fluoro-Jade C staining. EBA-laminin double immunolabeling demonstrated that the expressions of laminin were predominantly localized in the areas (cortex, thalamus and hippocampus) where EBA has been either reduced or is absent. Our results from these experiments demonstrate that vascular laminin expression increases after treatment with KA or 3-NPA, suggesting the occurrence of neovascularization. Microglia may also contribute to the neurotoxic induced neovascularization and neurodegeneration. JF - Brain research AU - Sarkar, Sumit AU - Schmued, Larry AD - Division of Neurotoxicology, National Center for Toxicological Research (NCTR), Jefferson, AR 72079, USA. Y1 - 2010/09/17/ PY - 2010 DA - 2010 Sep 17 SP - 239 EP - 247 VL - 1352 KW - Antigens, CD11b KW - 0 KW - Laminin KW - Neurotoxins KW - Nitro Compounds KW - Propionates KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Laminin -- metabolism KW - Antigens, CD11b -- metabolism KW - Blood-Brain Barrier -- physiology KW - Neurotoxins -- pharmacology KW - Antigens, CD11b -- drug effects KW - Motor Activity -- physiology KW - Tremor -- chemically induced KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Behavior, Animal -- drug effects KW - Laminin -- drug effects KW - Gait -- physiology KW - Hypothermia -- chemically induced KW - Behavior, Animal -- physiology KW - Motor Activity -- drug effects KW - Gait -- drug effects KW - Immunohistochemistry KW - Kainic Acid -- pharmacology KW - Propionates -- pharmacology KW - Nitro Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748971393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Kainic+acid+and+3-Nitropropionic+acid+induced+expression+of+laminin+in+vascular+elements+of+the+rat+brain.&rft.au=Sarkar%2C+Sumit%3BSchmued%2C+Larry&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2010-09-17&rft.volume=1352&rft.issue=&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2010.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-22 N1 - Date created - 2010-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2010.07.011 ER - TY - JOUR T1 - ISA software suite: supporting standards-compliant experimental annotation and enabling curation at the community level AN - 818831388; 13719984 AB - SUMMARY: The first open source software suite for experimentalists and curators that (i) assists in the annotation and local management of experimental metadata from high-throughput studies employing one or a combination of omics and other technologies; (ii) empowers users to uptake community-defined checklists and ontologies; and (iii) facilitates submission to international public repositories. JF - Bioinformatics AU - Rocca-Serra, Philippe AU - Brandizi, Marco AU - Maguire, Eamonn AU - Sklyar, Nataliya AU - Taylor, Chris AU - Begley, Kimberly AU - Field, Dawn AU - Harris, Stephen AU - Hide, Winston AU - Hofmann, Oliver AU - Neumann, Steffen AU - Sterk, Peter AU - Tong, Weida AU - Sansone, Susanna-Assunta AD - The European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SD and Oxford e-Research Centre, University of Oxford, 7 Keble Road, Oxford OX1 3QG, Natural Environment Research Council, Environmental Bioinformatics Centre, Wallingford CEH, Benson Lane, Mansfield Road, Oxford OX10 8BB, UK, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA, Genomic Standards Consortium, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK, US Food and Drug Administration, Center for Bioinformatics, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA and Leibniz Institute of Plant Biochemistry, Department of Stress and Developmental Biology, Weinberg 3, 06120 Halle, Germany Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 2354 EP - 2356 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 26 IS - 18 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Check lists KW - high-throughput screening KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818831388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=ISA+software+suite%3A+supporting+standards-compliant+experimental+annotation+and+enabling+curation+at+the+community+level&rft.au=Rocca-Serra%2C+Philippe%3BBrandizi%2C+Marco%3BMaguire%2C+Eamonn%3BSklyar%2C+Nataliya%3BTaylor%2C+Chris%3BBegley%2C+Kimberly%3BField%2C+Dawn%3BHarris%2C+Stephen%3BHide%2C+Winston%3BHofmann%2C+Oliver%3BNeumann%2C+Steffen%3BSterk%2C+Peter%3BTong%2C+Weida%3BSansone%2C+Susanna-Assunta&rft.aulast=Rocca-Serra&rft.aufirst=Philippe&rft.date=2010-09-15&rft.volume=26&rft.issue=18&rft.spage=2354&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Check lists; high-throughput screening; Bioinformatics ER - TY - JOUR T1 - Meat and components of meat and the risk of bladder cancer in the NIH-AARP Diet and Health Study? AN - 1017962837; 16689052 AB - BACKGROUND: Meat could be involved in bladder carcinogenesis via multiple potentially carcinogenic meat-related compounds related to cooking and processing, including nitrate, nitrite, heterocyclic amines (HCAs), and polycyclic aromatic hydrocarbons (PAHs). The authors comprehensively investigated the association between meat and meat components and bladder cancer. METHODS: During 7 years of follow-up, 854 transitional cell bladder-cancer cases were identified among 300,933 men and women who had completed a validated food-frequency questionnaire in the large prospective NIH-AARP Diet and Health Study. The authors estimated intake of nitrate and nitrite from processed meat and HCAs and PAHs from cooked meat by using quantitative databases of measured values. Total dietary nitrate and nitrite were calculated based on literature values. RESULTS: The hazard ratios (HR) and 95% confidence intervals (CI) for red meat (HR for fifth quintile compared with first quintile, 1.22; 95% CI, 0.96-1.54; Ptrend = .07) and the HCA 2-amino-1 methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) (HR, 1.19; 95% CI, 0.95-1.48; Ptrend = .06) conferred a borderline statistically significant increased risk of bladder cancer. Positive associations were observed in the top quintile for total dietary nitrite (HR, 1.28; 95% CI, 1.02-1.61; Ptrend = .06) and nitrate plus nitrite intake from processed meat (HR, 1.29; 95% CI, 1.00-1.67; Ptrend = .11). CONCLUSIONS: These findings provided modest support for an increased risk of bladder cancer with total dietary nitrite and nitrate plus nitrite from processed meat. Results also suggested a positive association between red meat and PhIP and bladder carcinogenesis. Cancer 2010. ? 2010 American Cancer Society. JF - Cancer AU - Ferrucci, Leah M AU - Sinha, Rashmi AU - Ward, Mary H AU - Graubard, Barry I AU - Hollenbeck, Albert R AU - Kilfoy, Briseis A AU - Schatzkin, Arthur AU - Michaud, Dominique S AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, crossa@mail.nih.gov Y1 - 2010/09/15/ PY - 2010 DA - 2010 Sep 15 SP - 4345 EP - 4353 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 18 SN - 1097-0142, 1097-0142 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Amines KW - Cancer KW - Carcinogenesis KW - Carcinogenicity KW - Diets KW - Meat KW - Nitrates KW - Nitrites KW - Urinary bladder KW - cooking KW - meat KW - urinary bladder KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017962837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Meat+and+components+of+meat+and+the+risk+of+bladder+cancer+in+the+NIH-AARP+Diet+and+Health+Study%3F&rft.au=Ferrucci%2C+Leah+M%3BSinha%2C+Rashmi%3BWard%2C+Mary+H%3BGraubard%2C+Barry+I%3BHollenbeck%2C+Albert+R%3BKilfoy%2C+Briseis+A%3BSchatzkin%2C+Arthur%3BMichaud%2C+Dominique+S%3BCross%2C+Amanda+J&rft.aulast=Ferrucci&rft.aufirst=Leah&rft.date=2010-09-15&rft.volume=116&rft.issue=18&rft.spage=4345&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.25463 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.25463/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Meat; Diets; urinary bladder; Nitrates; Nitrites; Urinary bladder; Carcinogenicity; Carcinogenesis; meat; cooking; Amines; Cancer DO - http://dx.doi.org/10.1002/cncr.25463 ER - TY - JOUR T1 - Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium AN - 759316559; 13721190 AB - BACKGROUND: Previous studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose-response, and duration of cigarette smoking cessation. METHODS: We used primary data from 10 population-based case-control studies and two cohort studies from the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Analyses were restricted to white non-Hispanic men and women. Patients were classified as having esophageal adenocarcinoma (n = 1540), esophagogastric junctional adenocarcinoma (n = 1450), or a combination of both (all adenocarcinoma; n = 2990). Control subjects (n = 9453) were population based. Associations between pack-years of cigarette smoking and risks of adenocarcinomas were assessed, as well as their potential modification by sex and duration of smoking cessation. Study-specific odds ratios (ORs) estimated using multivariable logistic regression models, adjusted for age, sex, body mass index, education, and gastroesophageal reflux, were pooled using a meta-analytic methodology to generate summary odds ratios. All statistical tests were two-sided. RESULTS: The summary odds ratios demonstrated strong associations between cigarette smoking and esophageal adenocarcinoma (OR = 1.96, 95% confidence interval [CI] = 1.64 to 2.34), esophagogastric junctional adenocarcinoma (OR = 2.18, 95% CI = 1.84 to 2.58), and all adenocarcinoma (OR = 2.08, 95% CI = 1.83 to 2.37). In addition, there was a strong dose-response association between pack-years of cigarette smoking and each outcome (P < .001). Compared with current smokers, longer smoking cessation was associated with a decreased risk of all adenocarcinoma after adjusting for pack-years (<10 years of smoking cessation: OR = 0.82, 95% CI = 0.60 to 1.13; and .10 years of smoking cessation: OR = 0.71, 95% CI = 0.56 to 0.89). Sex-specific summary odds ratios were similar. CONCLUSIONS: Cigarette smoking is associated with increased risks of adenocarcinomas of the esophagus and esophagogastric junction in white men and women; compared with current smoking, smoking cessation was associated with reduced risks. JF - Journal of the National Cancer Institute AU - Cook, Michael B AU - Kamangar, Farin AU - Whiteman, David C AU - Freedman, Neal D AU - Gammon, Marilie D AU - Bernstein, Leslie AU - Brown, Linda M AU - Risch, Harvey A AU - Ye, Weimin AU - Sharp, Linda AU - Pandeya, Nirmala AU - Webb, Penelope M AU - Wu, Anna H AU - Ward, Mary H AU - Giffen, Carol AU - Casson, Alan G AU - Abnet, Christian C AU - Murray, Liam J AU - Corley, Douglas A AU - Nyren, Olof AU - Vaughan, Thomas L AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (MBC, FK, NDF, MHW, CCA, W-HC) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1344 EP - 1353 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Age KW - Cigarettes KW - Statistical analysis KW - tumors KW - Models KW - risk reduction KW - Smoking KW - body mass KW - Dose-response effects KW - Cigarette smoking KW - Regression analysis KW - Drug addiction KW - Sex KW - Esophagus KW - Data processing KW - Barrett's esophagus KW - Tumors KW - Cancer KW - Education KW - Gastroesophageal reflux KW - Body mass index KW - Adenocarcinoma KW - X 24380:Social Poisons & Drug Abuse KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cigarette+Smoking+and+Adenocarcinomas+of+the+Esophagus+and+Esophagogastric+Junction%3A+A+Pooled+Analysis+From+the+International+BEACON+Consortium&rft.au=Cook%2C+Michael+B%3BKamangar%2C+Farin%3BWhiteman%2C+David+C%3BFreedman%2C+Neal+D%3BGammon%2C+Marilie+D%3BBernstein%2C+Leslie%3BBrown%2C+Linda+M%3BRisch%2C+Harvey+A%3BYe%2C+Weimin%3BSharp%2C+Linda%3BPandeya%2C+Nirmala%3BWebb%2C+Penelope+M%3BWu%2C+Anna+H%3BWard%2C+Mary+H%3BGiffen%2C+Carol%3BCasson%2C+Alan+G%3BAbnet%2C+Christian+C%3BMurray%2C+Liam+J%3BCorley%2C+Douglas+A%3BNyren%2C+Olof%3BVaughan%2C+Thomas+L%3BChow%2C+Wong-Ho&rft.aulast=Cook&rft.aufirst=Michael&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1344&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Data processing; Barrett's esophagus; Statistical analysis; Tumors; Models; Smoking; Gastroesophageal reflux; Cigarette smoking; Regression analysis; Adenocarcinoma; Drug addiction; Body mass index; Sex; risk reduction; Age; Education; Cigarettes; body mass; Dose-response effects; tumors; Cancer ER - TY - JOUR T1 - Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort AN - 759316492; 13721189 AB - BACKGROUND: Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations. METHODS: We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided. RESULTS: We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 person-years). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 person-years). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome. CONCLUSION: Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk. JF - Journal of the National Cancer Institute AU - Freedman, Neal D AU - Cross, Amanda J AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Everhart, James E AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (NDF, AJC, KAM, CCA, YP, AS, RS) Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1354 EP - 1365 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 17 SN - 0027-8874, 0027-8874 KW - Toxicology Abstracts; Risk Abstracts KW - Heterocyclic amines KW - Nitrate KW - Heme KW - Statistical analysis KW - Models KW - Risk factors KW - meat KW - Regression analysis KW - Nitrite KW - Hepatocellular carcinoma KW - Diets KW - Mortality KW - Liver diseases KW - Nitrates KW - Amines KW - Cancer KW - Meat KW - N-Nitroso compounds KW - Nitrites KW - Liver KW - quinoxaline KW - Iron KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+Meat+and+Fat+Intake+With+Liver+Disease+and+Hepatocellular+Carcinoma+in+the+NIH-AARP+Cohort&rft.au=Freedman%2C+Neal+D%3BCross%2C+Amanda+J%3BMcGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BEverhart%2C+James+E%3BSinha%2C+Rashmi&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2010-09-08&rft.volume=102&rft.issue=17&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Nitrate; Heterocyclic amines; Mortality; Liver diseases; Heme; Statistical analysis; Models; Meat; N-Nitroso compounds; Risk factors; quinoxaline; Regression analysis; Nitrite; Iron; Hepatocellular carcinoma; Nitrates; Nitrites; meat; Liver; Amines; Cancer ER - TY - JOUR T1 - Protective Role of Interleukin-10 in Ozone-Induced Pulmonary Inflammation AN - 1677990664; 14160336 AB - The mechanisms underlying ozone (O3)-induced pulmonary inflammation remain unclear. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that is known to inhibit inflammatory mediators. We investigated the molecular mechanisms underlying interleuken-10 (IL-10)-mediated attenuation of O3-induced pulmonary inflammation in mice. Il10-deficient (Il10-/-) and wild-type (Il10+/+) mice were exposed to 0.3 ppm O3 or filtered air for 24, 48, or 72 hr. Immediately after exposure, differential cell counts and total protein (a marker of lung permeability) were assessed from bronchoalveolar lavage fluid (BALF). mRNA and protein levels of cellular mediators were determined from lung homogenates. We also used global mRNA expression analyses of lung tissue with Ingenuity Pathway Analysis to identify patterns of gene expression through which IL-10 modifies O3-induced inflammation. Mean numbers of BALF polymorphonuclear leukocytes (PMNs) were significantly greater in Il10-/- mice than in Il10+/+ mice after exposure to O3 at all time points tested. O3-enhanced nuclear NF- Kappa B translocation was elevated in the lungs of Il10-/- compared with Il10+/+ mice. Gene expression analyses revealed several IL-10-dependent and O3-dependent mediators, including macrophage inflammatory protein 2, cathepsin E, and serum amyloid A3. Results indicate that IL-10 protects against O3-induced pulmonary neutrophilic inflammation and cell proliferation. Moreover, gene expression analyses identified three response pathways and several genetic targets through which IL-10 may modulate the innate and adaptive immune response. These novel mechanisms of protection against the pathogenesis of O3-induced pulmonary inflammation may also provide potential therapeutic targets to protect susceptible individuals. JF - Environmental Health Perspectives AU - Backus, Gillian S AU - Howden, Reuben AU - Fostel, Jennifer AU - Bauer, Alison K AU - Cho, Hye-Youn AU - Marzec, Jacqui AU - Peden, David B AU - Kleeberger, Steven R AD - National Institute of Environmental Health Sciences, Laboratory of Respiratory Biology, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 1721 EP - 1727 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 2 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - air pollution KW - gene array KW - IL-10 KW - inflammation KW - lung KW - ozone KW - pulmonary KW - Gene expression KW - Cellular KW - Pathways KW - Protein A KW - Proteins KW - Lungs KW - Cytokines KW - Mice KW - Protective UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677990664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Protective+Role+of+Interleukin-10+in+Ozone-Induced+Pulmonary+Inflammation&rft.au=Backus%2C+Gillian+S%3BHowden%2C+Reuben%3BFostel%2C+Jennifer%3BBauer%2C+Alison+K%3BCho%2C+Hye-Youn%3BMarzec%2C+Jacqui%3BPeden%2C+David+B%3BKleeberger%2C+Steven+R&rft.aulast=Backus&rft.aufirst=Gillian&rft.date=2010-09-08&rft.volume=118&rft.issue=2&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1289/ehp.1002182 ER - TY - JOUR T1 - The Medical Reserve Corps as Part of the Federal Medical and Public Health Response in Disaster Settings AN - 1257782534; 17458521 AB - The Secretary of the Department of Health and Human Services (HHS), through the Office of the Assistant Secretary for Preparedness and Response (ASPR), coordinates federal Emergency Support Function (ESF) #8 preparedness, response, and recovery actions. To address these needs, the ASPR can draw on trained personnel from a variety of sources, both from within and outside HHS. Among the resources under the domain of HHS is the Medical Reserve Corps (MRC), directed by the Office of the Civilian Volunteer Medical Reserve Corps (OCVMRC) in the Office of the Surgeon General. MRC units are community based and function as a way to locally organize and utilize medical and public health professionals, such as physicians, nurses, pharmacists, dentists, veterinarians, and epidemiologists. Nonclinical volunteers, such as interpreters, chaplains, office workers, legal advisors, and others, can fill logistical and support roles in MRC units. This article discusses locally controlled (Hurricanes Gustav and Ike) and federalized (Hurricanes Katrina and Rita) MRC activations, and it describes the advantages of using medical volunteers in a large-scale disaster response setting. JF - Biosecurity and Bioterrorism AU - Frasca AD - Office of Emergency Operations, Office of Crisis Management, Food and Drug Administration, Room 12A55 Parklawn, 5600 Fishers Lane, Rockville, MD 20852, USA, dominic.frasca@fda.hhs.gov Y1 - 2010/09/08/ PY - 2010 DA - 2010 Sep 08 SP - 265 EP - 271 VL - 8 IS - 3 SN - 1538-7135, 1538-7135 KW - Health & Safety Science Abstracts KW - Community involvement KW - Dentistry KW - Disasters KW - Hurricanes KW - Medical personnel KW - Nursing KW - Public health KW - Veterinary medicine KW - bioterrorism KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257782534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosecurity+and+Bioterrorism&rft.atitle=The+Medical+Reserve+Corps+as+Part+of+the+Federal+Medical+and+Public+Health+Response+in+Disaster+Settings&rft.au=Frasca&rft.aulast=Frasca&rft.aufirst=&rft.date=2010-09-08&rft.volume=8&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Biosecurity+and+Bioterrorism&rft.issn=15387135&rft_id=info:doi/10.1089%2Fbsp.2010.0006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2013-01-11 N1 - SubjectsTermNotLitGenreText - Hurricanes; Veterinary medicine; bioterrorism; Community involvement; Nursing; Disasters; Dentistry; Medical personnel; Public health DO - http://dx.doi.org/10.1089/bsp.2010.0006 ER - TY - JOUR T1 - Stability of the Neurotensin Receptor NTS1 Free in Detergent Solution and Immobilized to Affinity Resin AN - 954581383; 13748883 AB - Purification of recombinant membrane receptors is commonly achieved by use of an affinity tag followed by an additional chromatography step if required. This second step may exploit specific receptor properties such as ligand binding. However, the effects of multiple purification steps on protein yield and integrity are often poorly documented. We have previously reported a robust two-step purification procedure for the recombinant rat neurotensin receptor NTS1 to give milligram quantities of functional receptor protein. First, histidine-tagged receptors are enriched by immobilized metal affinity chromatography using Ni-NTA resin. Second, remaining contaminants in the Ni-NTA column eluate are removed by use of a subsequent neurotensin column yielding pure NTS1. Whilst the neurotensin column eluate contained functional receptor protein, we observed in the neurotensin column flow-through misfolded NTS1. To investigate the origin of the misfolded receptors, we estimated the amount of functional and misfolded NTS1 at each purification step by radio-ligand binding, densitometry of Coomassie stained SDS-gels, and protein content determination. First, we observed that correctly folded NTS1 suffers damage by exposure to detergent and various buffer compositions as seen by the loss of [3H]neurotensin binding over time. Second, exposure to the neurotensin affinity resin generated additional misfolded receptor protein. Our data point towards two ways by which misfolded NTS1 may be generated: Damage by exposure to buffer components and by close contact of the receptor to the neurotensin affinity resin. Because NTS1 in detergent solution is stabilized by neurotensin, we speculate that the occurrence of aggregated receptor after contact with the neurotensin resin is the consequence of perturbations in the detergent belt surrounding the NTS1 transmembrane core. Both effects reduce the yield of functional receptor protein. JF - PLoS ONE AU - White, Jim F AU - Grisshammer, Reinhard AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America Y1 - 2010/09/07/ PY - 2010 DA - 2010 Sep 07 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 5 IS - 9 KW - Toxicology Abstracts KW - Affinity chromatography KW - Neurotensin KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954581383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Stability+of+the+Neurotensin+Receptor+NTS1+Free+in+Detergent+Solution+and+Immobilized+to+Affinity+Resin&rft.au=White%2C+Jim+F%3BGrisshammer%2C+Reinhard&rft.aulast=White&rft.aufirst=Jim&rft.date=2010-09-07&rft.volume=5&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0012579 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Neurotensin DO - http://dx.doi.org/10.1371/journal.pone.0012579 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats AN - 954521659; 13366062 AB - Bisphenol A (BPA) is an important industrial chemical used in the manufacture of polycarbonate plastic products and epoxy resin-based food can liners. The presence of BPA in urine of >90% of Americans aged 6-60 suggests ubiquitous and frequent exposure. The current study used LC/MS/MS to measure serum pharmacokinetics of aglycone (active) and conjugated (inactive) BPA in adult and neonatal Sprague-Dawley rats by oral and injection routes. Deuterated BPA was used to avoid issues of background contamination. Linear pharmacokinetics were observed in adult rats treated orally in the range of 0-200I14g/kg bw. Evidence for enterohepatic recirculation of conjugated, but not aglycone, BPA was observed in adult rats. Significant inverse relationships were observed between postnatal age and measures of internal exposures to aglycone BPA and its elimination. In neonatal rats treated orally, internal exposures to aglycone BPA were substantially lower than from subcutaneous injection. The results reinforce the critical role for first-pass Phase II metabolism of BPA in gut and liver after oral exposure that attenuates internal exposure to the aglycone form in rats of all ages. The internal exposures to aglycone BPA observed in adult and neonatal rats following a single oral dose of 100I14g/kg bw are inconsistent with effects mediated by classical estrogen receptors based on binding affinities. However, an impact on alternative estrogen signaling pathways that have higher receptor affinity cannot be excluded in neonatal rats. These findings emphasize the importance of matching aglycone BPA internal dosimetry with receptor affinities in experimental animal studies reporting toxicity. JF - Toxicology and Applied Pharmacology AU - Doerge, Daniel R AU - Twaddle, Nathan C AU - Vanlandingham, Michelle AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 158 EP - 165 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 247 IS - 2 SN - 0041-008X, 0041-008X KW - Environment Abstracts; Toxicology Abstracts KW - Age KW - Rats KW - Aglycones KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954521659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+neonatal+and+adult+Sprague-Dawley+rats&rft.au=Doerge%2C+Daniel+R%3BTwaddle%2C+Nathan+C%3BVanlandingham%2C+Michelle%3BFisher%2C+Jeffrey+W&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2010-09-01&rft.volume=247&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Aglycones; Rats DO - http://dx.doi.org/10.1016/j.taap.2010.06.008 ER - TY - JOUR T1 - Carbohydrate metabolic pathway genes associated with quantitative trait loci (QTL) for obesity and type 2 diabetes: Identification by data mining AN - 888099251; 15039606 AB - Increasing consumption of refined carbohydrates is now being recognized as a primary contributor to the development of nutritionally related chronic diseases such as obesity and type 2 diabetes mellitus (T2DM). A data mining approach was used to evaluate the role of carbohydrate metabolic pathway genes in the development of obesity and T2DM. Data from public databases were used to map the position of the carbohydrate metabolic pathway genes to known quantitative trait loci (QTL) for obesity and T2DM and for examining the pathway genes for the presence of sequence and structural genetic variants such as single nucleotide polymorphisms (SNPs) and copy number variants (CNS), respectively. The results demonstrated that a majority of the genes of the carbohydrate metabolic pathways are associated with QTL for obesity and many for T2DM. In addition, some key genes of the pathways also encode non-synonymous SNPs that exhibit significant differences in population frequencies. This study emphasizes the significance of the metabolic pathways genes in the development of disease phenotypes, its differential occurrence across populations and between individuals, and a strategy for interpreting an individuals' risk for disease. JF - Biotechnology Journal AU - Varma, Vijayalakshmi AU - Wise, Carolyn AU - Kaput, Jim Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 942 EP - 949 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 5 IS - 9 SN - 1860-7314, 1860-7314 KW - Genetics Abstracts; Physical Education Index; Biotechnology and Bioengineering Abstracts KW - Carbohydrates KW - Central nervous system KW - Chronic diseases KW - Data processing KW - Databases KW - Diabetes KW - Diabetes mellitus KW - Diseases KW - Genetics KW - Metabolic pathways KW - Obesity KW - Quantitative trait loci KW - Single-nucleotide polymorphism KW - Strategy KW - copy number KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888099251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+Journal&rft.atitle=Carbohydrate+metabolic+pathway+genes+associated+with+quantitative+trait+loci+%28QTL%29+for+obesity+and+type+2+diabetes%3A+Identification+by+data+mining&rft.au=Varma%2C+Vijayalakshmi%3BWise%2C+Carolyn%3BKaput%2C+Jim&rft.aulast=Varma&rft.aufirst=Vijayalakshmi&rft.date=2010-09-01&rft.volume=5&rft.issue=9&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Biotechnology+Journal&rft.issn=18607314&rft_id=info:doi/10.1002%2Fbiot.201000067 L2 - http://onlinelibrary.wiley.com/doi/10.1002/biot.201000067/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-12-14 N1 - SubjectsTermNotLitGenreText - Genetics; Obesity; Strategy; Chronic diseases; Diseases; Carbohydrates; Diabetes; Diabetes mellitus; Databases; Central nervous system; Quantitative trait loci; Data processing; Single-nucleotide polymorphism; Metabolic pathways; copy number DO - http://dx.doi.org/10.1002/biot.201000067 ER - TY - GEN T1 - Highlights from the Technical Assistance and Child Care Resources Sponsored by the Office of Child Care. Office of Child Care Pathways and Partnerships Priorities. Issue Number 2 AN - 881464751; ED520493 AB - The Office of Child Care (OCC) administers the Child Care and Development Fund (CCDF) program, a multibillion-dollar Federal and State partnership to support access to high-quality child care for working families. OCC helps States, Territories, and Tribes administer their CCDF programs through program support, policy guidance, technical assistance, and research. This OCC newsletter contains the following: (1) Resource Spotlight on School-Age and Quality Rating and Improvement Systems; (2) Emerging Projects; (3) Targeted Resources: School-Age Care; (4) Spotlight on New Resources; (5) Planned Technical Assistance Activities; and (6) School-Age Quick Facts. (Contains 7 endnotes.) Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 2 PB - Office of Child Care. US Department of Health and Human Services, Administration for Children and Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - Rhode Island KW - Minnesota KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Partnerships in Education KW - Employed Parents KW - Resource Materials KW - Child Care KW - Educational Improvement KW - Quality Control KW - Technical Assistance KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881464751?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOEUGENOL (CAS NO. 97-54-1) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 878683494; 21372857 AB - Isoeugenol is a fragrant oil found in many plants including clove, nutmeg, sandalwood, dill seed, gardenia and petunia. It is used in cleaning products, perfumes, and foods and also as an anesthetic in fisheries. We studied the effects of isoeugenol on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing isoeugenol in corn oil directly into the stomach through a tube to groups of 50 male and female rats and mice for two years. Exposed animals received either 75, 150, or 300 milligrams of isoeugenol per kilogram of body weight. Control animals received corn oil with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. There were increased rates of liver cancer (hepatocellular adenoma and hepatocellular carcinoma) in male mice exposed to isoeugenol. Two male rats given 300 mg/kg isoeugenol developed rare neoplasms of the thyroid gland and two others developed rare mammary gland carcinomas. There was an increased rate of histiocytic sarcomas in female mice exposed to isoeugenol. Atrophy, metaplasia, or degeneration of the olfactory epithelium of the nose was seen in all groups of male and female rats and mice exposed to isoeugenol. We conclude that isoeugenol caused liver cancer in male mice. The occurrence of rare thyroid and mammary gland tumors in male rats and increased incidences of histiocytic sarcomas in female mice may have been associated with exposure to isoeugenol. Exposure to isoeugenol caused a variety of lesions of the olfactory epithelium of the nose in rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 178 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Eugenol KW - isoeugenol KW - Rodents KW - Genetics KW - Carcinogens KW - Chemical compounds KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Eugenol -- toxicity KW - Dose-Response Relationship, Drug KW - Humans KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Eugenol -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+ISOEUGENOL+%28CAS+NO.+97-54-1%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=551&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683493 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=551&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683492 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683491 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.atitle=Survey+and+risk+assessment+of+trace+elements+in+foods+from+Taiwan+containing+red+mould+rice+%28Monascus%29+by+ICP-MS&rft.au=Tsai%2C+C-F%3BShih%2C+DY-C%3BShyu%2C+Y-T&rft.aulast=Tsai&rft.aufirst=C-F&rft.date=2010-12-01&rft.volume=3&rft.issue=4&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+B+-+Surveillance+Communications&rft.issn=19393210&rft_id=info:doi/10.1080%2F19393210.2010.513070 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683358 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA [CAS NO. 481-72-1 (Aloe-emodin)] IN SKH-1 MICE (SIMULATED SOLAR LIGHT AND TOPICAL APPLICATION STUDY) AN - 878683355; 21031007 AB - Extracts from the Aloe vera plant are widely used in skin care products. We studied the effects of synthetic solar light on the skin of hairless mice that had been treated with creams containing various Aloe vera extracts. We applied creams containing Aloe vera plant extracts (aloe gel, whole leaf, or decolorized whole leaf) or aloe-emodin to groups of 36 male and female hairless mice in the morning; other groups received creams containing no aloe. In the afternoon groups of animals were exposed to synthetic solar light for four hours. Other groups were not exposed to light and were control groups. The treatments and exposures were performed five days per week for 40 weeks, during which the animals were monitored for development of skin cancers. Mice exposed to synthetic solar light developed significant increases in squamous cell neoplasms and squamous cell nonneoplastic lesions of the skin whether or not they received treatment with cream. Female mice, but not male mice, treated with aloe gel or aloe-emodin and exposed to simulated solar light had increased numbers of squamous cell neoplasms when compared with mice treated with the carrier cream without the aloe gel or aloe-emodin and exposed to the same intensity of light. For both male and female mice, inclusion of aloe whole leaf extract or decolorized leaf extract in the cream increased the number of squamous cell neoplasms when the animals were exposed to simulated solar light. We conclude that aloe gel or aloe-emodin had a weak enhancing effect on the photocarcinogenic activity of simulated solar light in female but not male hairless mice. We conclude that aloe whole leaf extract and decolorized leaf extract had a weak enhancing effect on the photocarcinogenic activity of simulated solar light in both male and female hairless mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 33, 35-97, 99-103 passim CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Plant Extracts KW - Skin cancer KW - Radiation KW - Flowers & plants KW - Skin care products KW - Animals KW - Carcinogenicity Tests KW - Mice KW - Mice, Hairless KW - Male KW - Female KW - Administration, Topical KW - Aloe -- toxicity KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Plant Extracts -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+PHOTOCOCARCINOGENESIS+STUDY+OF+ALOE+VERA+%5BCAS+NO.+481-72-1+%28Aloe-emodin%29%5D+IN+SKH-1+MICE+%28SIMULATED+SOLAR+LIGHT+AND+TOPICAL+APPLICATION+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=553&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Exposure science can increase protection of workers and their families from exposure to asbestos and inform on the effects of other elongate mineral particles AN - 877596953; 13709746 JF - Journal of Exposure Science and Environmental Epidemiology AU - Howard, John AU - Middendorf, Paul AD - National Institute for Occupational Safety and Health, Washington, DC, USA Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 485 EP - 486 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 6 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Asbestos KW - Particulates KW - Minerals KW - Occupational exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877596953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Exposure+science+can+increase+protection+of+workers+and+their+families+from+exposure+to+asbestos+and+inform+on+the+effects+of+other+elongate+mineral+particles&rft.au=Howard%2C+John%3BMiddendorf%2C+Paul&rft.aulast=Howard&rft.aufirst=John&rft.date=2010-09-01&rft.volume=20&rft.issue=6&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2010.40 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Asbestos; Particulates; Minerals; Occupational exposure DO - http://dx.doi.org/10.1038/jes.2010.40 ER - TY - JOUR T1 - Formulation and stability of a novel artificial human sweat under conditions of storage and use AN - 877589600; 13668023 AB - A limitation of most artificial sweat formulations used for in vitro assessment of chemical release from materials in contact with skin have little biological relevance to human sweat. The purposes of this paper are to provide guidance for preparation of a novel artificial sweat with chemical constituents at concentrations that match human sweat and to characterize chemical stability. The artificial sweat was characterized under conditions of use (with and without sebum at 36AC) and storage (without sebum at a4, 4, and 23AC) over 28days by gas chromatography-mass spectroscopy, high-performance liquid chromatography, enzymatic assay kits, and ion-selective electrodes. Seven indicator constituents were tracked: sodium, chloride, glucose, lactic acid, urea, pantothenic acid, and alanine. With or without sebum at 36AC, the sweat solvent was chemically stable for 14days. Storage by refrigeration at 4AC retained the chemical integrity of the solvent longest. Based on these results, the solvent should be used within 14days of preparation. The artificial sweat model presented herein is most similar to human sweat and has applications as a dissolution solvent, donor solution in diffusion cells, or vehicle for patch testing. This sweat model may aid researchers in understanding potential release and percutaneous absorption of chemicals in contact with human skin surface liquids. JF - Toxicology In Vitro AU - Harvey, Christopher J AU - LeBouf, Ryan F AU - Stefaniak, Aleksandr B AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA, AStefaniak@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1790 EP - 1796 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 24 IS - 6 SN - 0887-2333, 0887-2333 KW - Toxicology Abstracts KW - Alanine KW - Sweat KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877589600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Formulation+and+stability+of+a+novel+artificial+human+sweat+under+conditions+of+storage+and+use&rft.au=Harvey%2C+Christopher+J%3BLeBouf%2C+Ryan+F%3BStefaniak%2C+Aleksandr+B&rft.aulast=Harvey&rft.aufirst=Christopher&rft.date=2010-09-01&rft.volume=24&rft.issue=6&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2010.06.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Sweat DO - http://dx.doi.org/10.1016/j.tiv.2010.06.016 ER - TY - JOUR T1 - Metal-based nanoparticles and their toxicity assessment AN - 869590347; 14821164 AB - Nanoparticles (NPs) can potentially cause adverse effects on organ, tissue, cellular, subcellular, and protein levels due to their unusual physicochemical properties (e.g., small size, high surface area to volume ratio, chemical composition, crystallinity, electronic properties, surface structure reactivity and functional groups, inorganic or organic coatings, solubility, shape, and aggregation behavior). Metal NPs, in particular, have received increasing interest due to their widespread medical, consumer, industrial, and military applications. However, as particle size decreases, some metal-based NPs are showing increased toxicity, even if the same material is relatively inert in its bulk form (e.g., Ag, Au, and Cu). NPs also interact with proteins and enzymes within mammalian cells and they can interfere with the antioxidant defense mechanism leading to reactive oxygen species generation, the initiation of an inflammatory response and perturbation and destruction of the mitochondria causing apoptosis or necrosis. As a result, there are many challenges to overcome before we can determine if the benefits outweigh the risks associated with NPs. WIREs Nanomed Nanobiotechnol 2010 2 544-568 JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Schrand, Amanda M AU - Rahman, Mohammad F AU - Hussain, Saber M AU - Schlager, John J AU - Smith, David A AU - Syed, Ali F AD - Wright-Patterson Air Force Base, Dayton, OH 45433, USA, syed.ali@fda.hhs.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 544 EP - 568 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK VL - 2 IS - 5 SN - 1939-0041, 1939-0041 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Particle size KW - Metals KW - Crystallinity KW - Solubility KW - Antioxidants KW - Apoptosis KW - Surface area KW - Physicochemical properties KW - Mitochondria KW - Enzymes KW - Copper KW - Toxicity KW - Inflammation KW - Aggregation behavior KW - Necrosis KW - Mammalian cells KW - Reactive oxygen species KW - Consumers KW - Defense mechanisms KW - nanoparticles KW - Side effects KW - nanotechnology KW - Coatings KW - W 30910:Imaging KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869590347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Metal-based+nanoparticles+and+their+toxicity+assessment&rft.au=Schrand%2C+Amanda+M%3BRahman%2C+Mohammad+F%3BHussain%2C+Saber+M%3BSchlager%2C+John+J%3BSmith%2C+David+A%3BSyed%2C+Ali+F&rft.aulast=Schrand&rft.aufirst=Amanda&rft.date=2010-09-01&rft.volume=2&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19390041&rft_id=info:doi/10.1002%2Fwnan.103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Particle size; Metals; Crystallinity; Apoptosis; Antioxidants; Solubility; Surface area; Physicochemical properties; Enzymes; Mitochondria; Toxicity; Copper; Inflammation; Necrosis; Aggregation behavior; Reactive oxygen species; Mammalian cells; Consumers; Defense mechanisms; nanoparticles; Side effects; Coatings; nanotechnology DO - http://dx.doi.org/10.1002/wnan.103 ER - TY - JOUR T1 - Low molecular weight hyaluronic acid effects on murine macrophage nitric oxide production AN - 869574563; 14821722 AB - Hyaluronic acid (HA) is increasingly used for a number of medical device applications. Since the chemical structure of HA is identical no matter its bacterial or animal origin, it should be the ideal biomaterial. However, short term transient inflammatory reactions are common, while rare long-term adverse events may correlate with subclinical chronic inflammation. Concern has been raised that low molecular weight components or degradation fragments from implanted HA may directly stimulate inflammatory reactions. This study examined a panel of HA molecular weights from the unitary disaccharide up to 1.7 x 10 super(6) Dalton lengths, in which endotoxin was assayed at a very low level (less than 0.03 EU/mg). The murine cell line RAW 264.7, rat splenocytes, and rat adherent differentiated primary macrophages were assayed for nitric oxide production under a variety of inflammatory conditions plus or minus HA. Under the highest inflammatory states, nitric oxide production was mildly suppressed by HMW-HA while slightly augmented by LMW-HA at mg/mL concentrations. However, at micromolar concentrations fragments below 5000 Daltons, thought to have drug-like qualities, were without effect. These data support the hypothesis that if endotoxin is reduced to an extremely low level, LMW-HA may not directly provoke normal tissue macrophage-mediated inflammatory reactions. JF - Journal of Biomedical Materials Research, Part A AU - Lyle, Daniel B AU - Breger, Joyce C AU - Baeva, Larissa F AU - Shallcross, Jonathan C AU - Durfor, Charles N AU - Wang, Nam Sun AU - Langone, John J AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, FDA, 10903 New Hampshire Ave, Silver Spring, Maryland 20993-002, john.langone@fda.hhs.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 893 EP - 904 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 94A IS - 3 SN - 1552-4965, 1552-4965 KW - Biotechnology and Bioengineering Abstracts KW - biomaterials KW - nitric oxide KW - inflammation KW - macrophage KW - hyaluronic acid KW - Endotoxins KW - Macrophages KW - Hyaluronic acid KW - Splenocytes KW - Data processing KW - Molecular weight KW - Biomaterials KW - Nitric oxide KW - Inflammation KW - Disaccharides KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869574563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.atitle=Low+molecular+weight+hyaluronic+acid+effects+on+murine+macrophage+nitric+oxide+production&rft.au=Lyle%2C+Daniel+B%3BBreger%2C+Joyce+C%3BBaeva%2C+Larissa+F%3BShallcross%2C+Jonathan+C%3BDurfor%2C+Charles+N%3BWang%2C+Nam+Sun%3BLangone%2C+John+J&rft.aulast=Lyle&rft.aufirst=Daniel&rft.date=2010-09-01&rft.volume=94A&rft.issue=3&rft.spage=893&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.issn=15524965&rft_id=info:doi/10.1002%2Fjbm.a.32760 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Endotoxins; Splenocytes; Hyaluronic acid; Data processing; Molecular weight; Biomaterials; Nitric oxide; Disaccharides; Inflammation DO - http://dx.doi.org/10.1002/jbm.a.32760 ER - TY - JOUR T1 - Well-being at work - overview and perspective AN - 867745940; 13674293 AB - This paper provides an overview of and perspective on the concept of well-being at work. Well-being is a term that reflects not only on one's health but satisfaction with work and life. Well-being is a summative concept that characterizes the quality of working lives, including occupational safety and health (OSH) aspects, and it may be a major determinant of productivity at the individual, enterprise and societal levels. Based on a review of the literature and a recent conference, we suggest a model linking workforce well-being, productivity, and population well-being. To appraise the validity of the model, we consider five questions: (i) is there a robust and usable definition of workplace well-being? (ii) have the variables that influence well-being been aptly described and can they be measured and used in risk assessments? (iii) what is the nature of evidence that well-being is linked to productivity? (iv) what is the state of knowledge on the effectiveness of interventions to promote workplace well-being? and (v) should interventions aimed at improving well-being at work focus on more than work-related factors?. JF - Scandinavian Journal of Work, Environment & Health AU - Schulte, P AU - Vainio, H AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, Ohio 45226, USA, pschulte@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 422 EP - 429 VL - 36 IS - 5 SN - 0355-3140, 0355-3140 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Conferences KW - intervention KW - Reviews KW - Occupational safety KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867745940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.atitle=Well-being+at+work+-+overview+and+perspective&rft.au=Schulte%2C+P%3BVainio%2C+H&rft.aulast=Schulte&rft.aufirst=P&rft.date=2010-09-01&rft.volume=36&rft.issue=5&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Work%2C+Environment+%26+Health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Conferences; Reviews; intervention; Occupational safety ER - TY - JOUR T1 - The frequency-dependence of the nicotine-induced inhibition of dopamine is controlled by the a7 nicotinic receptor AN - 867741147; 13823806 AB - J. Neurochem. (2010) 114, 1659-1666.AbstractVoltammetric analyses show that low (100-500 nM) doses of nicotine regulate striatal dopamine by inhibiting release evoked by a single stimulation to a greater extent than release evoked by high frequency stimulations. This frequency-dependent inhibition is because of nicotine desensitizing heteromeric b2 subunit-containing nicotinic acetylcholine receptor (nAChR) subtypes. Surprisingly, a high dose of nicotine (2 kM; capable of interacting with additional nAChR subtypes) produced an inhibition of dopamine evoked by high frequency stimulation, an effect that was not seen with the low dose of nicotine or the b2 antagonist, dihydro-b-erythroidine hydrobromide. This inhibition was replicated by application of a7 nAChR antagonists methyllcaconitine citrate or a-bungarotoxin in conjunction with the low dose of nicotine or dihydro-b-erythroidine hydrobromide. Blocking a7 receptor function alone produced a modest increase in dopamine evoked by single pulse stimulation while not affecting dopamine evoked by high frequency stimulation. The antagonist results were mimicked using selective a7 agonists PHA 543613 and PNU 282987. The frequency dependence of the low dose nicotine inhibition therefore requires functional a7 nAChRs, and may arise from differing levels of endogenous acetylcholine evoked by the stimulation. JF - Journal of Neurochemistry AU - Seipel, Andrew T AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA, yakel@niehs.nih.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1659 EP - 1666 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 114 IS - 6 SN - 0022-3042, 0022-3042 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Acetylcholine receptors (nicotinic) KW - Bungarotoxin KW - Citric acid KW - Dopamine KW - Frequency dependence KW - Neostriatum KW - Nicotine KW - Receptor mechanisms KW - X 24380:Social Poisons & Drug Abuse KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867741147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ISME+Journal&rft.atitle=Population+dynamics+of+Vibrio+spp.+associated+with+marine+sponge+microcosms&rft.au=Hoffmann%2C+Maria%3BFischer%2C+Markus%3BOttesen%2C+Andrea%3BMcCarthy%2C+Peter+J%3BLopez%2C+Jose+V%3BBrown%2C+Eric+W%3BMonday%2C+Steven+R&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2010-12-01&rft.volume=4&rft.issue=12&rft.spage=1608&rft.isbn=&rft.btitle=&rft.title=ISME+Journal&rft.issn=17517362&rft_id=info:doi/10.1038%2Fismej.2010.85 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Number of references - 25 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Dopamine; Bungarotoxin; Receptor mechanisms; Nicotine; Neostriatum; Frequency dependence; Acetylcholine receptors (nicotinic); Citric acid DO - http://dx.doi.org/10.1111/j.1471-4159.2010.06883.x ER - TY - JOUR T1 - Real-Time PCR Assay for the Detection of Pufferfish Products AN - 860372032; 13709712 AB - An assay was developed for the rapid detection of products containing tissues from potentially toxic pufferfish (family Tetraodontidae), as part of the U.S. Food and Drug Administration Center for Veterinary Medicine and Center for Food Safety and Applied Nutrition's charter to protect human health. In this study, we developed a TaqMan assay derived from DNA barcode data (650 bp starting at the 5' end of the mitochondrial cytochrome c oxidase I gene) for the specific detection of pufferfish. The method requires only 1 h of total run time, a significant improvement over current methods, which can require 24 to 96 h for completion. The probes were tested against 105 species of fish and were able to detect 20 species of pufferfish; no cross-reactivity was shown with 85 species of nonpufferfish, including 20 related species from the same order (Tetraodontiformes). These results demonstrate that this assay is suitable for the rapid and specific detection of pufferfish and that it could be a useful regulatory tool to protect human health. JF - Journal of Food Protection AU - Jones, Yolanda L AU - Oliver, Haley F AU - Deeds, Jonathan R AU - Yancy, Haile F AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, Maryland 20708; 2 Cornell University, Department of Food Science, 410B Stocking Hall, Ithaca, New York 14860; and 3U.S. Food and Drug Administration, Center for Food Safetyand Applied Nutrition, 5100 Paintbranch Parkway, College Park, Maryland 20740, USA, Yolanda.Jones@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1698 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 73 IS - 9 SN - 0362-028X, 0362-028X KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - Cytochromes KW - Nucleotide sequence KW - Animal physiology KW - Toxicity KW - Nutrition KW - Public health KW - Marine fish KW - Tetraodontiformes KW - USA KW - DNA KW - Tetraodontidae KW - Drugs KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q5 08504:Effects on organisms KW - Q1 08423:Behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860372032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Real-Time+PCR+Assay+for+the+Detection+of+Pufferfish+Products&rft.au=Jones%2C+Yolanda+L%3BOliver%2C+Haley+F%3BDeeds%2C+Jonathan+R%3BYancy%2C+Haile+F&rft.aulast=Jones&rft.aufirst=Yolanda&rft.date=2010-09-01&rft.volume=73&rft.issue=9&rft.spage=1698&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 28 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Marine fish; Cytochromes; Nucleotide sequence; DNA; Animal physiology; Toxicity; Drugs; Nutrition; Public health; Tetraodontiformes; Tetraodontidae; USA; Marine ER - TY - JOUR T1 - Performance Testing of Huber Needles for Coring of Port Septa AN - 818840960; 13791063 AB - The Food and Drug Administration received complaints of Huber needles creating cores in the septa of ports of gastric banding devices. One of these complaints represented a cluster of similar events, even though no deviations from design specifications or recommended practices were subsequently identified by the manufacturer. The authors conducted this comparative investigation of off-the-shelf Huber needles and ports from several manufacturers to determine if engineering parameters could be identified that could account for the coring complaints. Huber needles from ten manufacturers were evaluated for coring using intravascular access ports from five manufacturers. A detailed optical analysis was also performed to identify needle features that would possibly account for coring. The majority of the tested needles performed as they should, i.e., they perforated the port septa without creating cores. However, needles that did produce cores were found to have sharp edges at the heel edge of the needle lumen, the edge of the ground bevel opposite from the needle tip that opens to the inner surface of the cannula tube. Manufacturing processes, which dulled or rounded the sharp heel of the bevel after bevel grinding, prevented coring. As a result of this investigation one manufacturer voluntarily recalled their product and another manufacturer implemented coring testing as part of their quality control. To prevent coring needles from entering the market as a result of manufacturing flaws, optical inspection of the heel edge and coring testing should be performed as part of routine quality control. JF - Journal of Medical Devices (Transactions of the ASME) AU - Vesnovsky, Oleg AU - Casamento, Jon P AU - Brooks, Mary E AU - Schwerin, Matthew R AU - Herman, William A AU - Pollack, Steven K AU - Flack, Marilyn N AU - Collins, Betty W AU - Grossman, Laurence W AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993 Y1 - 2010/09// PY - 2010 DA - Sep 2010 PB - ASME International, 22 Law Drive Fairfield NJ 07007-2900 USA VL - 4 IS - 3 SN - 1932-6181, 1932-6181 KW - Biotechnology and Bioengineering Abstracts KW - Coring KW - Quality control KW - Septum KW - Banding KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818840960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Devices+%28Transactions+of+the+ASME%29&rft.atitle=Performance+Testing+of+Huber+Needles+for+Coring+of+Port+Septa&rft.au=Vesnovsky%2C+Oleg%3BCasamento%2C+Jon+P%3BBrooks%2C+Mary+E%3BSchwerin%2C+Matthew+R%3BHerman%2C+William+A%3BPollack%2C+Steven+K%3BFlack%2C+Marilyn+N%3BCollins%2C+Betty+W%3BGrossman%2C+Laurence+W&rft.aulast=Vesnovsky&rft.aufirst=Oleg&rft.date=2010-09-01&rft.volume=4&rft.issue=3&rft.spage=031008+%287%29&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Devices+%28Transactions+of+the+ASME%29&rft.issn=19326181&rft_id=info:doi/10.1115%2F1.4001866YouarenotloggedintotheASMEDigitalLibrary. L2 - http://asmedl.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=JMDOA4000004000003031008000001&idtype=cvips&gifs=Yes LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Coring; Quality control; Banding; Septum DO - http://dx.doi.org/10.1115/1.4001866YouarenotloggedintotheASMEDigitalLibrary. ER - TY - JOUR T1 - In situ estimation of roof rock strength using sonic logging AN - 818639392; 2011-006426 AB - Sonic travel time logging of exploration boreholes is routinely used in Australia to obtain estimates of coal mine roof rock strength. Because sonic velocity logs are relatively inexpensive and easy to obtain during exploration, the technique has provided Australian underground coal mines with an abundance of rock strength data for use in all aspects of ground control design. However, the technique depends upon reliable correlations between the uniaxial compressive strength (UCS) and the sonic velocity. This paper describes research recently conducted by NIOSH aimed at developing a correlation for use by the U.S. mining industry. From two coreholes in Illinois, two from Pennsylvania, and one each from Colorado, western Kentucky and southern West Virginia, sonic velocity logs were compared with UCS values derived from Point Load tests for a broad range of coal measure rock types. For the entire data set, the relationship between UCS and sonic travel time is expressed by an exponential equation relating the UCS in psi to the travel time of the P-wave in mu s/ft. The coefficient of determination or R-squared for this equation is 0.72, indicating that a relatively high reliability can be achieved with this technique. The strength estimates obtained from the correlation equation may be used to help design roof support systems. The paper also addresses the steps that are necessary to ensure that high-quality sonic logs are obtained for use in estimating UCS. JF - International Journal of Coal Geology AU - Oyler, David C AU - Mark, Christopher AU - Molinda, Gregory M Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 484 EP - 490 PB - Elsevier, Amsterdam VL - 83 IS - 4 SN - 0166-5162, 0166-5162 KW - United States KW - mining KW - underground mining KW - roof control KW - well-logging KW - coal fields KW - uniaxial tests KW - rock mechanics KW - sedimentary rocks KW - coal KW - Australia KW - mines KW - well logs KW - Illinois KW - Australasia KW - geophysical methods KW - coal mines KW - equations KW - depth KW - physical properties KW - boreholes KW - acoustical logging KW - compressive strength KW - Pennsylvania KW - coal deposits KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818639392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=In+situ+estimation+of+roof+rock+strength+using+sonic+logging&rft.au=Oyler%2C+David+C%3BMark%2C+Christopher%3BMolinda%2C+Gregory+M&rft.aulast=Oyler&rft.aufirst=David&rft.date=2010-09-01&rft.volume=83&rft.issue=4&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2010.07.002 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2011-01-01 N1 - Number of references - 18 N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustical logging; Australasia; Australia; boreholes; coal; coal deposits; coal fields; coal mines; compressive strength; depth; equations; geophysical methods; Illinois; mines; mining; Pennsylvania; physical properties; rock mechanics; roof control; sedimentary rocks; underground mining; uniaxial tests; United States; well logs; well-logging DO - http://dx.doi.org/10.1016/j.coal.2010.07.002 ER - TY - JOUR T1 - Evaluation of Pulsed-Field Gel Electrophoresis Profiles for Identification of Salmonella Serotypes AN - 807261523; 13664879 AB - Pulsed-field gel electrophoresis (PFGE) is a standard typing method for isolates from Salmonella outbreaks and epidemiological investigations. Eight hundred sixty-six Salmonella enterica isolates from eight serotypes, including Heidelberg (n = 323), Javiana (n = 200), Typhimurium (n = 163), Newport (n = 93), Enteritidis (n = 45), Dublin (n = 25), Pullorum (n = 9), and Choleraesuis (n = 8), were subjected to PFGE, and their profiles were analyzed by random forest classification and compared to conventional hierarchical cluster analysis to determine potential predictive relationships between PFGE banding patterns and particular serotypes. Cluster analysis displayed only the underlying similarities and relationships of the isolates from the eight serotypes. However, for serotype prediction of a nonserotyped Salmonella isolate from its PFGE pattern, random forest classification provided better accuracy than conventional cluster analysis. Discriminatory DNA band class markers were identified for distinguishing Salmonella serotype Heidelberg, Javiana, Typhimurium, and Newport isolates. JF - Journal of Clinical Microbiology AU - Zou, Wen AU - Lin, Wei-Jiun AU - Foley, Steven L AU - Chen, Chun-Houh AU - Nayak, Rajesh AU - Chen, James J AD - Division of Personalized Nutrition and Medicine, jamesj.chen@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 3122 EP - 3126 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 9 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Typing KW - Classification KW - Salmonella enterica KW - Pulsed-field gel electrophoresis KW - DNA KW - Forests KW - Pest outbreaks KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807261523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Pulsed-Field+Gel+Electrophoresis+Profiles+for+Identification+of+Salmonella+Serotypes&rft.au=Zou%2C+Wen%3BLin%2C+Wei-Jiun%3BFoley%2C+Steven+L%3BChen%2C+Chun-Houh%3BNayak%2C+Rajesh%3BChen%2C+James+J&rft.aulast=Zou&rft.aufirst=Wen&rft.date=2010-09-01&rft.volume=48&rft.issue=9&rft.spage=3122&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00645-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 22 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Typing; Serotypes; Classification; DNA; Pulsed-field gel electrophoresis; Forests; Pest outbreaks; Salmonella enterica DO - http://dx.doi.org/10.1128/JCM.00645-10 ER - TY - JOUR T1 - Novel architectural features of Bordetella pertussis fimbrial subunit promoters and their activation by the global virulence regulator BvgA AN - 807260662; 13666653 AB - SummaryA prominent feature of the promoters of Bordetella pertussis fimbrial subunit genes fim2, fim3 and fimX is the presence of a 'C-stretch', a monotonic run of C residues. The C-stretch renders these genes capable of phase variation, through spontaneous variations in its length. For each of these we determined the length of the C-stretch that gave maximal transcriptional activity, and found that the three optimized promoters align perfectly, with identical distances between conserved upstream sequences and the downstream -10 elements and transcriptional start sites. We also demonstrated, for Pfim3, that the conserved sequence corresponds to BvgA binding sites. The more upstream of the two binding sites is predicted to be high affinity, by comparison to a functionally derived consensus BvgA-binding sequence. The other binding site is a fairly poor match to this consensus, with 10 of 14 bp belonging to the C-stretch. Interestingly, the centre of this downstream site of BvgA binding coincides exactly with the centre of the expected typical location of a -35 sequence. However, the lack of a recognizable -35 element (CCCCCC versus TTGACA), and the occupation of this site by BvgA6P suggest that activation of the fim promoters involves unusual interactions among BvgA, RNA polymerase and promoter DNA. JF - Molecular Microbiology AU - Chen, Qing AU - Decker, Kimberly Baxter AU - Boucher, Philip E AU - Hinton, Deborah AU - Stibitz, Scott AD - 1Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1326 EP - 1340 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 77 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Virulence KW - Promoters KW - Pertussis KW - Bordetella pertussis KW - DNA-directed RNA polymerase KW - Phase variations KW - DNA KW - Conserved sequence KW - Transcription KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807260662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Novel+architectural+features+of+Bordetella+pertussis+fimbrial+subunit+promoters+and+their+activation+by+the+global+virulence+regulator+BvgA&rft.au=Chen%2C+Qing%3BDecker%2C+Kimberly+Baxter%3BBoucher%2C+Philip+E%3BHinton%2C+Deborah%3BStibitz%2C+Scott&rft.aulast=Chen&rft.aufirst=Qing&rft.date=2010-09-01&rft.volume=77&rft.issue=5&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2010.07293.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 45 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Virulence; Pertussis; Promoters; DNA-directed RNA polymerase; Phase variations; DNA; Transcription; Conserved sequence; Bordetella pertussis DO - http://dx.doi.org/10.1111/j.1365-2958.2010.07293.x ER - TY - JOUR T1 - Effects of gloves on the total grip strength applied to cylindrical handles AN - 787287602; 13715405 AB - The major objectives of this study were to establish an alternative method for measuring the effects of gloves on the grip strength applied to cylindrical handles and to quantify the strength reduction due to the use of typical anti-vibration (AV) gloves. Different from previous studies that measure the grip force in a specific plane, the alternative method measures the total contact force normal to a cylindrical handle; the total grip strength is defined as the total contact force measured when a subject applies a power grip to the handle with his/her maximum voluntary contraction (MVC) effort. Two instrumented cylindrical handles (30 and 40 mm) were used in this study. ten subjects participated in the experiment. Four types of AV gloves and two types of non-AV gloves were used in the experiment. Compared with bare-handed trials, each of the four anti-vibration gloves reduced the grip strength by more than 29%, regardless of handle size. One of the non-AV gloves also largely reduced the grip strength (>=25%) whereas the grip strength reduction of the other one was less than 10%. The gloves also influenced the grip force distribution pattern around the circumference of the cylindrical handles. The results suggest that the thickness of a glove is one of the major factors associated with these effects. Relevance to industry - Glove use is generally recommended to keep the hands warm and dry and to protect them from many other hazards, provided this is consistent with safe and effective tool operation. However, a user of thicker, stiffer gloves, such as some AV gloves, could be trading one health risk for another. Knowledge of the effects of gloves on grip strength can help workers, managers, and safety professionals make informed decisions about glove selection and use in the workplace. This knowledge may also lead to work glove improvements. JF - International Journal of Industrial Ergonomics AU - Wimer, Bryan AU - McDowell, Thomas W AU - Xu, Xueyan S AU - Welcome, Daniel E AU - Warren, Christopher AU - Dong, Ren G AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, MS L-2027, WV 26505, USA, TMcDowell@cdc.gov Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 574 EP - 583 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 40 IS - 5 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Glove KW - Grip force KW - Grip strength KW - Anti-vibration gloves KW - Hand force KW - Risk assessment KW - gloves KW - Ergonomics KW - H 10000:Ergonomics/Human Factors KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/787287602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Effects+of+gloves+on+the+total+grip+strength+applied+to+cylindrical+handles&rft.au=Wimer%2C+Bryan%3BMcDowell%2C+Thomas+W%3BXu%2C+Xueyan+S%3BWelcome%2C+Daniel+E%3BWarren%2C+Christopher%3BDong%2C+Ren+G&rft.aulast=Wimer&rft.aufirst=Bryan&rft.date=2010-09-01&rft.volume=40&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2010.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; gloves; Ergonomics DO - http://dx.doi.org/10.1016/j.ergon.2010.05.004 ER - TY - JOUR T1 - Measuring addiction propensity and severity: The need for a new instrument AN - 772276066; 201029810 AB - Drug addiction research requires but lacks a valid and reliable way to measure both the risk (propensity) to develop addiction and the severity of manifest addiction. This paper argues for a new measurement approach and instrument to quantify propensity to and severity of addiction, based on the testable assumption that these constructs can be mapped onto the same dimension of liability to addiction. The case for this new direction becomes clear from a critical review of empirical data and the current instrumentation. The many assessment instruments in use today have proven utility, reliability, and validity, but they are of limited use for evaluating individual differences in propensity and severity. The conceptual and methodological shortcomings of instruments currently used in research and clinical practice can be overcome through the use of new technologies to develop a reliable, valid, and standardized assessment instrument(s) to measure and distinguish individual variations in expression of the underlying latent trait(s) that comprises propensity to and severity of drug addiction. Such instrumentation would enhance our capacity for drug addiction research on linkages and interactions among familial, genetic, psychosocial, and neurobiological factors associated with variations in propensity and severity. It would lead to new opportunities in substance abuse prevention, treatment, and services research, as well as in interventions and implementation science for drug addiction. [Copyright Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Conway, Kevin P AU - Levy, Janet AU - Vanyukov, Michael AU - Chandler, Redonna AU - Rutter, Joni AU - Swan, Gary E AU - Neale, Michael AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 6001 Executive Blvd., Room 5153, MSC 9589, Bethesda, MD 20892-9589, USA kconway@nida.nih.gov Y1 - 2010/09/01/ PY - 2010 DA - 2010 Sep 01 SP - 4 EP - 12 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 111 IS - 1-2 SN - 0376-8716, 0376-8716 KW - Tobacco Cannabis assessment Individual differences Adolescents KW - Clinical assessment KW - Severity KW - Psychosocial factors KW - Addiction KW - Drug addiction KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/772276066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Measuring+addiction+propensity+and+severity%3A+The+need+for+a+new+instrument&rft.au=Conway%2C+Kevin+P%3BLevy%2C+Janet%3BVanyukov%2C+Michael%3BChandler%2C+Redonna%3BRutter%2C+Joni%3BSwan%2C+Gary+E%3BNeale%2C+Michael&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2010-09-01&rft.volume=111&rft.issue=1-2&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2010.03.011 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-11-11 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Drug addiction; Severity; Addiction; Substance abuse; Clinical assessment; Psychosocial factors DO - http://dx.doi.org/10.1016/j.drugalcdep.2010.03.011 ER - TY - JOUR T1 - Fecal-Orally Transmitted Diseases Among Travelers Are Decreasing Due to Better Hygienic Standards at Travel Destination AN - 759313193; 13666584 AB - Objective. To evaluate whether changes in attack rates of fecal-orally transmitted diseases among travelers are related to changes in pretravel vaccination practices or better hygienic standards at travel destination. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Sonder, Gerard JB AU - van der Loeff, Maarten FSchim AU - Coutinho, Roel A AU - van den Hoek, Anneke AD - *Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands, gbaaten@ggd.amsterdam.nl Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 322 EP - 328 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 17 IS - 5 SN - 1195-1982, 1195-1982 KW - Health & Safety Science Abstracts KW - Hygiene KW - Travel KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Fecal-Orally+Transmitted+Diseases+Among+Travelers+Are+Decreasing+Due+to+Better+Hygienic+Standards+at+Travel+Destination&rft.au=Baaten%2C+Gijs+G%3BSonder%2C+Gerard+JB%3Bvan+der+Loeff%2C+Maarten+FSchim%3BCoutinho%2C+Roel+A%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2010-09-01&rft.volume=17&rft.issue=5&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2010.00442.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 14 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Travel; Hygiene DO - http://dx.doi.org/10.1111/j.1708-8305.2010.00442.x ER - TY - JOUR T1 - How HealthPlans, Health Systems, and Others in the Private Sector Canm Stimulate 'Meaningful Use' AN - 758116911; 2010-627798 AB - Provisions of the American Recovery & Reinvestment Act authorize incentive payments to hospitals & clinicians who become "meaningful users" of health information technology (IT). We argue that various private-sector entities -- commercial payers, employers, consumer groups, health care ratings organizations, large provider organizations, & regulatory bodies -- can further accelerate health IT adoption by implementing strategies that are complementary to the Medicare & Medicaid incentive programs. This paper describes these strategies & potential approaches to implementation. Adapted from the source document. JF - Health Affairs AU - Jain, Sachin H AU - Seidman, Joshua AU - Blumenthal, David AD - U.S. Dept Health & Human Services, Washington, D.C sachin.jain@hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 1667 EP - 1670 PB - Project HOPE, Bethesda MD VL - 29 IS - 9 SN - 0278-2715, 0278-2715 KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Science and technology policy - Computer science and information technology KW - Health conditions and policy - Medicine and health care KW - Economic conditions and policy - Consumers and consumption KW - Health conditions and policy - Hospitals and other health care facilities KW - Information Technology KW - Insurance KW - Managed Care KW - Health Reform KW - Rating KW - Medicare KW - Health insurance KW - Consumers KW - Information technology KW - Medical service KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758116911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=How+HealthPlans%2C+Health+Systems%2C+and+Others+in+the+Private+Sector+Canm+Stimulate+%27Meaningful+Use%27&rft.au=Jain%2C+Sachin+H%3BSeidman%2C+Joshua%3BBlumenthal%2C+David&rft.aulast=Jain&rft.aufirst=Sachin&rft.date=2010-09-01&rft.volume=29&rft.issue=9&rft.spage=1667&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2010.0766 LA - English DB - PAIS Index N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health insurance; Information technology; Medical service; Rating; Consumers; Hospitals; Medicare DO - http://dx.doi.org/10.1377/hlthaff.2010.0766 ER - TY - JOUR T1 - Nurses and the Affordable Care Act AN - 758112467; 201029369 AB - New legislation gives nurses a greater voice. Adapted from the source document. JF - American Journal of Nursing AU - Wakefield, Mary K AD - U.S. Health Resources & Services Administration, Washington, DC administrator@hrsa.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 11 PB - Lippincott Williams & Wilkins, Philadelphia PA VL - 110 IS - 9 SN - 0002-936X, 0002-936X KW - Nurses KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758112467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Nursing&rft.atitle=Nurses+and+the+Affordable+Care+Act&rft.au=Wakefield%2C+Mary+K&rft.aulast=Wakefield&rft.aufirst=Mary&rft.date=2010-09-01&rft.volume=110&rft.issue=9&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Nursing&rft.issn=0002936X&rft_id=info:doi/10.1097%2F01.NAJ.0000388242.06365.4f LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nurses; Legislation DO - http://dx.doi.org/10.1097/01.NAJ.0000388242.06365.4f ER - TY - JOUR T1 - The in silico prediction of human-specific metabolites from hepatotoxic drugs. AN - 755972481; 20843294 AB - In this study we employed the use of the Meteor computational software program to perform predictions in silico on 17 hepatotoxic drugs for determining human-specific drug metabolites. Congruence of the in silico predictions from a qualitative standpoint of drug metabolite structures was established by comparison to human in vivo drug metabolic profiles characterized in publically available clinical studies. A total of 87 human-specific metabolites were identified from the 17 drugs. We found that Meteor's positive predictions included 4 out of the 9 reported major metabolites (detected in excreta at a level of >10% of the administered p.o. dose) and 10 out of the 15 major phase II metabolites giving a total of 14 correctly predicted drug metabolite structures out of 23 major metabolites. A significant level of unconfirmed positive predictions resulted and discussion on reasons for this is presented. An example is given whereby the in silico metabolism prediction succeeded to predict the putative toxic pathway of one of the drugs whilst conventional rodent liver microsomal assays failed to predict the pathway. Overall, we describe a reasonable simulation of human metabolic profiling using this in silico method with this data set of hepatotoxic drugs now withdrawn from the market. We provide an in-depth and objective discussion of this first of its kind validation test using clinical study data with interest in the prediction human-specific metabolism. Further research is discussed on what areas need to be investigated to improve upon the predictive data. The strong potential of this method to predict human-specific drug metabolites suggests the utility of this computational tool to help support not only the discovery development of therapeutics but also the safety assessment in identifying drug metabolites early to protect patients prior to initiating clinical studies. JF - Current drug discovery technologies AU - Valerio, Luis G AU - Long, Anthony AD - Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Luis.Valerio@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 170 EP - 187 VL - 7 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Humans KW - Knowledge Bases KW - Software KW - Pharmaceutical Preparations -- metabolism KW - Computer Simulation KW - Pharmaceutical Preparations -- chemistry KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755972481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+discovery+technologies&rft.atitle=The+in+silico+prediction+of+human-specific+metabolites+from+hepatotoxic+drugs.&rft.au=Valerio%2C+Luis+G%3BLong%2C+Anthony&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-09-01&rft.volume=7&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Current+drug+discovery+technologies&rft.issn=1875-6220&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-03-10 N1 - Date created - 2010-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - RPRT T1 - FOREWORD AN - 755511290 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755511290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANDROSTENEDIONE (CAS NO. 63-05-8) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 755509507; 21037592 AB - Androstenedione is a natural androgen steroid hormone that is synthesized in men and women. Commercially it is used as an intermediate in the production of other steroids including oral contraceptives and anti-inflammatory products. Until its over-the-counter sales were banned in 2004, androstenedione was marketed as a supplement to aid athletes in gaining muscle mass. We studied the effects of androstenedione on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited androstenedione dissolved in methylcellulose solutions through a tube directly into the stomach to groups of 50 male and female rats and mice for two years. Male and female rats and male mice received 10, 20, or 50 milligrams of androstenedione per kilogram of body weight each day; female mice received 2, 10, or 50 mg/kg. Control animals received methylcellulose solutions with no chemical added by the same method. At the end of the study tissues from more than 40 sites were examined for every animal. A few adenomas and one carcinoma of the lung were seen in male rats receiving androstenedione and there was a slight increase in the rate of mononuclear cell leukemia in exposed female rats. Male and female mice given androstenedione had marked increases in a variety of liver tumors, including adenomas, carcinomas and hepatoblastomas. There were also increases in the rates of pancreatic islet adenomas in male and female mice. Female rats also had increased rates of hyperplasia of the pancreatic islets and atrophy of the exocrine pancreas. Female mice had very marked increases in the rates of hyperplasia of the clitoral gland, metaplasia in the kidney, and cytoplasmic alteration of the salivary gland. We conclude that androstenedione caused liver cancer and pancreatic islet cancer in male and female mice. The occurrence of lung tumors in male rats and mononuclear cell leukemia in female rats may have been related to androstendione exposure. Increases in nonneoplastic lesions of the pancreas in female rats and of the clitoral gland, kidney, and salivary gland in female mice were attributed to androstenedione exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 1 EP - 31,33-171 passim CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Biological Markers KW - Mutagens KW - Androstenedione KW - Steroids KW - Health hazards KW - Toxicology KW - Animals KW - Chemistry, Pharmaceutical KW - Dose-Response Relationship, Drug KW - Drug-Induced Liver Injury -- pathology KW - Intubation, Gastrointestinal KW - Androstenedione -- pharmacology KW - Mutagens -- toxicity KW - Mice KW - Rats KW - Genitalia -- drug effects KW - Drug-Induced Liver Injury -- metabolism KW - Mice, Inbred Strains KW - Estrous Cycle KW - Rats, Inbred F344 KW - Animal Feed KW - Micronucleus Tests KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Male KW - Female KW - Organ Size -- drug effects KW - Androstenedione -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+ANDROSTENEDIONE+%28CAS+NO.+63-05-8%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Document feature - Photographs; References; Diagrams; Graphs; Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 755509466 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-09-01&rft.volume=&rft.issue=560&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Histological and histomorphometrical analyses of biopsies harvested 11 years after maxillary sinus floor augmentation with deproteinized bovine and autogenous bone AN - 754537313; 13246030 AB - Objective: The purpose of the present study was to histologically and histomorphometrically evaluate the long-term tissue response to deproteinized bovine bone (DPBB) particles used in association with autogenous bone and to compare particle size after 6 months and 11 years, in the same patients, in order to determine possible resorption. Material and methods: Twenty consecutive patients (14 women and six men) with a mean age of 62 years (range 48-69 years) with severe atrophy of the posterior maxilla were included in this study. Thirty maxillary sinuses with <5mm subantral alveolar bone were augmented with a mixture of 80% DPBB and 20% autogenous bone. Eleven years (mean 11.5 years) after augmentation, biopsies were taken from the grafted areas of the 11 patients who volunteered to participate in this new surgical intervention. The following histomorphometrical measurements were performed in these specimens: total bone area in percentage, total area of the DPBB, total area of marrow space, the degree of DPBB-bone contact (percentage of the total surface length for each particle), the length of all DPBB particles and the area of all DPBB particles. The length and the area of the particles were compared with samples harvested from the same patients at 6 months (nine samples) and pristine particles from the manufacturer. Results: The biopsies consisted of 44.7 plus or minus 16.9% lamellar bone, 38 plus or minus 16.9% marrow space and 17.3 plus or minus 13.2% DPBB. The degree of DPBB to bone contact was 61.5 plus or minus 34%. There were no statistically significant differences between the length and area of the particles after 11 years compared with those measured after 6 months in the same patients or to pristine particles from the manufacturer. Conclusion: DPBB particles were found to be well integrated in lamellar bone, after sinus floor augmentation in humans, showing no significant changes in particle size after 11 years. JF - Clinical Oral Implants Research AU - Mordenfeld, Arne AU - Hallman, Mats AU - Johansson, Carina B AU - Albrektsson, Tomas AD - 1Department of Oral and Maxillofacial Surgery, Public Health Service, Gaevle, Sweden Y1 - 2010/09// PY - 2010 DA - Sep 2010 SP - 961 EP - 970 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 21 IS - 9 SN - 0905-7161, 0905-7161 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Dental restorative materials KW - Biopsy KW - Maxillary sinus KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754537313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Oral+Implants+Research&rft.atitle=Histological+and+histomorphometrical+analyses+of+biopsies+harvested+11+years+after+maxillary+sinus+floor+augmentation+with+deproteinized+bovine+and+autogenous+bone&rft.au=Mordenfeld%2C+Arne%3BHallman%2C+Mats%3BJohansson%2C+Carina+B%3BAlbrektsson%2C+Tomas&rft.aulast=Mordenfeld&rft.aufirst=Arne&rft.date=2010-09-01&rft.volume=21&rft.issue=9&rft.spage=961&rft.isbn=&rft.btitle=&rft.title=Clinical+Oral+Implants+Research&rft.issn=09057161&rft_id=info:doi/10.1111%2Fj.1600-0501.2010.01939.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Dental restorative materials; Biopsy; Maxillary sinus DO - http://dx.doi.org/10.1111/j.1600-0501.2010.01939.x ER - TY - JOUR T1 - The Role of the Federal Statistical System in Evidence-based Policymaking, or How to Make the Statistical System Essential AN - 754064687; 201050221 AB - This article discusses the strained nature of the relationship between the research/analytic world and the policy/political world. The research/analytic world in general and the statistical community in particular are portrayed as not wanting to be pulled into partisan politics. At the same time, the policy makers are portrayed as not seeing that statistical analysis is essential to confronting difficult real-world decisions. The article points out that there is a fundamental pressure pushing the two together: the federal budget. It shows that over the past decade or two, funding for statistical agencies has been under increasing pressure to show the "return on investment" of the taxpayers' dollars. The article suggests that the way out of this problem is by becoming an essential partner with the policy makers in dealing with the challenging issues that they face by supporting and advancing evidence-based policymaking. [Reprinted by permission of Sage Publications Inc., copyright The American Academy of Political and Social Science.] JF - The Annals of the American Academy of Political and Social Science AU - O'Grady, Michael J AD - National Opinion Research Center at the University of Chicago and the Department of Health and Human Services (HHS) Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 180 EP - 188 PB - Sage Publications, Thousand Oaks CA VL - 631 SN - 0002-7162, 0002-7162 KW - healthcare reform Office of Technology Assessment Health and Human Services KW - Taxation KW - Policy Making KW - Partisanship KW - Budgets KW - Investment KW - Quantitative Methods KW - article KW - 9043: methodology and research technology; research methods and models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754064687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.atitle=The+Role+of+the+Federal+Statistical+System+in+Evidence-based+Policymaking%2C+or+How+to+Make+the+Statistical+System+Essential&rft.au=O%27Grady%2C+Michael+J&rft.aulast=O%27Grady&rft.aufirst=Michael&rft.date=2010-09-01&rft.volume=631&rft.issue=&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+the+American+Academy+of+Political+and+Social+Science&rft.issn=00027162&rft_id=info:doi/10.1177%2F0002716210374154 LA - English DB - Worldwide Political Science Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 1 N1 - Last updated - 2016-09-28 N1 - CODEN - AAYPAV N1 - SubjectsTermNotLitGenreText - Policy Making; Quantitative Methods; Investment; Taxation; Partisanship; Budgets DO - http://dx.doi.org/10.1177/0002716210374154 ER - TY - JOUR T1 - The ABC transporter HrtAB confers resistance to hemin toxicity and is regulated in a hemin-dependent manner by the ChrAS two-component system in Corynebacterium diphtheriae. AN - 749001044; 20639324 AB - Corynebacterium diphtheriae, the causative agent of the severe respiratory disease diphtheria, utilizes hemin and hemoglobin as iron sources for growth in iron-depleted environments. Because of the toxicity of high levels of hemin and iron, these compounds are often tightly regulated in bacterial systems. In this report, we identify and characterize the C. diphtheriae hrtAB genes, which encode a putative ABC type transporter involved in conferring resistance to the toxic effects of hemin. Deletion of the hrtAB genes in C. diphtheriae produced increased sensitivity to hemin, which was complemented by a plasmid harboring the cloned hrtAB locus. The HrtAB system was not involved in the uptake and use of hemin as an iron source. The hrtAB genes are located on the C. diphtheriae genome upstream from the chrSA operon, which encodes a previously characterized two-component signal transduction system that regulates gene expression in a heme-dependent manner. The hrtB promoter is activated by the ChrAS system in the presence of hemin or hemoglobin, and mutations in the chrSA genes abolish heme-activated expression from the hrtB promoter. It was also observed that transcription from the hrtB promoter is reduced in a dtxR deletion mutant, suggesting that DtxR is required for optimal expression of hrtAB. Previous studies proposed that the ChrS sensor kinase may be responsive to an environmental signal, such as hemin. We show that specific point mutations in the ChrS N-terminal transmembrane domain result in a reduced ability to activate the hrtB promoter in the presence of a heme source, suggesting that this putative sensor region is essential for the detection of a signal produced in response to hemin exposure. This study shows that the HrtAB system is required for protection from hemin toxicity and that expression of the hrtAB genes is regulated by the ChrAS two-component system. This study demonstrates a direct correlation between the detection of heme or a heme-associated signal by the N-terminal sensor domain of ChrS and the transcriptional activation of the hrtAB genes. JF - Journal of bacteriology AU - Bibb, Lori A AU - Schmitt, Michael P AD - Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 4606 EP - 4617 VL - 192 IS - 18 KW - Bacterial Proteins KW - 0 KW - Hemoglobins KW - Hemin KW - 743LRP9S7N KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Hemoglobins -- metabolism KW - Gene Expression Regulation, Bacterial -- drug effects KW - Promoter Regions, Genetic -- genetics KW - Computational Biology KW - Iron -- metabolism KW - Gene Expression Regulation, Bacterial -- genetics KW - Hemin -- toxicity KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- chemistry KW - Corynebacterium diphtheriae -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Bacterial Proteins -- metabolism KW - ATP-Binding Cassette Transporters -- genetics KW - Corynebacterium diphtheriae -- genetics KW - Corynebacterium diphtheriae -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/749001044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=The+ABC+transporter+HrtAB+confers+resistance+to+hemin+toxicity+and+is+regulated+in+a+hemin-dependent+manner+by+the+ChrAS+two-component+system+in+Corynebacterium+diphtheriae.&rft.au=Bibb%2C+Lori+A%3BSchmitt%2C+Michael+P&rft.aulast=Bibb&rft.aufirst=Lori&rft.date=2010-09-01&rft.volume=192&rft.issue=18&rft.spage=4606&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.00525-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-13 N1 - Date created - 2010-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1997 Nov;65(11):4634-41 [9353044] J Mol Biol. 1975 Aug 5;96(2):307-16 [1100846] J Bacteriol. 1999 Sep;181(17):5330-40 [10464204] J Bacteriol. 1954 Feb;67(2):220-32 [13129217] J Bacteriol. 2005 Jan;187(2):422-33 [15629913] J Bacteriol. 2005 Aug;187(16):5658-64 [16077111] Infect Immun. 2005 Nov;73(11):7406-12 [16239540] J Bacteriol. 2006 Apr;188(8):2959-73 [16585757] PLoS Pathog. 2006 Aug;2(8):e87 [16933993] Microbiol Mol Biol Rev. 2006 Dec;70(4):910-38 [17158704] J Bacteriol. 2007 May;189(9):3650-4 [17322319] Infect Immun. 2007 May;75(5):2421-31 [17353293] J Biol Chem. 2007 Sep 7;282(36):26111-21 [17635909] Cell Host Microbe. 2007 Apr 19;1(2):109-19 [18005689] Nucleic Acids Res. 2008 Jan;36(Database issue):D281-8 [18039703] BMC Genomics. 2006;7:21 [16469103] J Biol Chem. 2009 Jan 9;284(2):1166-76 [18984582] J Bacteriol. 2009 Apr;191(8):2638-48 [19201805] Contrib Microbiol. 2009;16:120-35 [19494582] FEBS Lett. 2009 Jul 7;583(13):2244-8 [19505463] Amino Acids. 2009 Sep;37(3):479-86 [19259771] Mol Microbiol. 2009 May;72(3):763-78 [19400785] Proc Natl Acad Sci U S A. 1990 Aug;87(15):5968-72 [2116013] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Infect Immun. 1991 Jun;59(6):1899-904 [1828057] Microb Pathog. 1990 Oct;9(4):267-73 [2151460] J Bacteriol. 1991 Jul;173(14):4288-96 [2066330] Infect Immun. 1991 Nov;59(11):3903-8 [1718867] Crit Rev Microbiol. 1992;18(3):217-33 [1532495] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7576-80 [1502169] Annu Rev Genet. 1992;26:71-112 [1482126] Gene. 1994 Jul 22;145(1):69-73 [8045426] Mol Microbiol. 1994 Aug;13(4):719-32 [7997183] Mol Microbiol. 1995 Nov;18(3):383-90 [8748023] J Infect Dis. 1996 Nov;174(5):1064-72 [8896510] J Bacteriol. 1997 Feb;179(3):838-45 [9006041] Mol Microbiol. 2000 Apr;36(1):68-84 [10760164] J Bacteriol. 2001 Feb;183(4):1476-81 [11157965] Toxicon. 2001 Nov;39(11):1793-803 [11595641] Mol Microbiol. 2001 Nov;42(3):851-65 [11722747] DNA Cell Biol. 2002 Apr;21(4):281-95 [12042068] Biochem Soc Trans. 2002 Aug;30(4):691-6 [12196166] Microbes Infect. 2002 Sep;4(11):1149-56 [12361915] J Bacteriol. 2002 Dec;184(24):6882-92 [12446639] Nucleic Acids Res. 2003 Nov 15;31(22):6516-23 [14602910] J Bacteriol. 2003 Dec;185(23):6826-40 [14617647] Mol Microbiol. 2003 Nov;50(4):1429-38 [14622427] Contrib Microbiol. 2005;12:210-33 [15496782] J Biol Chem. 1998 Jan 9;273(2):837-41 [9422739] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/JB.00525-10 ER - TY - JOUR T1 - Chronic oral treatment with isotretinoin alters measures of activity but not anxiety in male and female rats. AN - 748946674; 20381607 AB - Use of the anti-acne drug, Accutane (ACC) (isotretinoin, 13-cis-retinoic acid), has been associated with neuropsychiatric events ranging from depression in animal models to depression and suicide ideation in humans. Our studies, however, have consistently indicated few effects on measures of depression in male and female rats. Still, the comorbidity of depression and anxiety suggests that anxiety assessments in ACC-treated rats could be informative. Such assessments must be balanced with measures of activity since drug-induced activity alterations may impact the expression of anxiety-like behaviors. Here, Sprague-Dawley rats (n=15/sex/dose) were gavaged daily with 0 (soy oil), 7.5, or 30 mg/kg/day ACC beginning on postnatal day (PND) 59. Blood ACC levels similar to humans taking recommended ACC doses are produced by 7.5mg/kg/day. Short-term activity was assessed in open fields prior to ACC treatment (PND 51) and again at PNDs 129 and 164 and in a complex environment at PNDs 66 and PND 184. Long-term residential activity was measured in running wheels (PNDs 85-92) and figure 8 mazes (PNDs 99-106). Anxiety-like behavior was assessed via elevated plus maze (EPM) activity on PND 98 and in a black/white apparatus on PND 125. The typical sex differences in most behaviors were exhibited (i.e., increased EPM open arm entries and overall activity in most measures in females); however, there were no significant effects of ACC treatment on open field activity, complex environment activity, residential running wheel activity, or EPM activity. Residential figure 8 maze activity indicated that male and female rats treated with 30 mg/kg/day were less active on all nights (p<0.05) and females treated with 7.5 or 30 mg/kg/day were less active than same-sex controls on most days (p<0.05). Similarly, rats of both sexes treated with 30 mg/kg/day were significantly less active in the black/white apparatus (p<0.05), entering the darkened area less frequently (p<0.05), although duration in the darkened area did not differ. These data indicate that at blood levels typically achieved by humans (i.e., the 7.5 mg/kg group), there are no significant anxiogenic effects associated with ACC treatment. At higher ACC levels, there are mild effects on activity but these appear to be apparatus- and/or age-specific. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Berry, Kimberly J AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Sherry.Ferguson@fda.hhs.gov PY - 2010 SP - 573 EP - 578 VL - 32 IS - 5 KW - Teratogens KW - 0 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Adaptation, Physiological -- drug effects KW - Rats, Sprague-Dawley KW - Maze Learning -- drug effects KW - Dose-Response Relationship, Drug KW - Exploratory Behavior -- drug effects KW - Locomotion -- drug effects KW - Male KW - Female KW - Isotretinoin -- administration & dosage KW - Behavior, Animal -- drug effects KW - Sex Characteristics KW - Teratogens -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748946674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Chronic+oral+treatment+with+isotretinoin+alters+measures+of+activity+but+not+anxiety+in+male+and+female+rats.&rft.au=Ferguson%2C+Sherry+A%3BBerry%2C+Kimberly+J&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2010-09-01&rft.volume=32&rft.issue=5&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2010.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-03 N1 - Date created - 2010-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2010.03.009 ER - TY - JOUR T1 - Challenges and opportunities in establishing scientific and regulatory standards for assuring therapeutic equivalence of modified release products: workshop summary report. AN - 733373207; 20440588 AB - Modified release products are complex dosage forms designed to release drug in a controlled manner to achieve desired efficacy and safety. Inappropriate control of drug release from such products may result in reduced efficacy or increased toxicity. This workshop provided an opportunity for pharmaceutical scientists from academia, industry, and regulatory agencies to discuss current industry practices and regulatory expectations for demonstrating pharmaceutical equivalence and bioequivalence of MR products, further facilitating the establishment of regulatory standards for ensuring therapeutic equivalence of these products. JF - The AAPS journal AU - Chen, Mei-Ling AU - Shah, Vinod P AU - Ganes, Derek AU - Midha, Kamal K AU - Caro, James AU - Nambiar, Prabu AU - Rocci, Mario L AU - Thombre, Avinash G AU - Abrahamsson, Bertil AU - Conner, Dale AU - Davit, Barbara AU - Fackler, Paul AU - Farrell, Colm AU - Gupta, Suneel AU - Katz, Russell AU - Mehta, Mehul AU - Preskorn, Sheldon H AU - Sanderink, Gerard AU - Stavchansky, Salomon AU - Temple, Robert AU - Wang, Yaning AU - Winkle, Helen AU - Yu, Lawrence AD - U.S. Food and Drug Administration, Silver Spring, Maryland, USA. meiling.chen@fda.hhs.gov Y1 - 2010/09// PY - 2010 DA - September 2010 SP - 371 EP - 377 VL - 12 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Therapeutic Equivalency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733373207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Challenges+and+opportunities+in+establishing+scientific+and+regulatory+standards+for+assuring+therapeutic+equivalence+of+modified+release+products%3A+workshop+summary+report.&rft.au=Chen%2C+Mei-Ling%3BShah%2C+Vinod+P%3BGanes%2C+Derek%3BMidha%2C+Kamal+K%3BCaro%2C+James%3BNambiar%2C+Prabu%3BRocci%2C+Mario+L%3BThombre%2C+Avinash+G%3BAbrahamsson%2C+Bertil%3BConner%2C+Dale%3BDavit%2C+Barbara%3BFackler%2C+Paul%3BFarrell%2C+Colm%3BGupta%2C+Suneel%3BKatz%2C+Russell%3BMehta%2C+Mehul%3BPreskorn%2C+Sheldon+H%3BSanderink%2C+Gerard%3BStavchansky%2C+Salomon%3BTemple%2C+Robert%3BWang%2C+Yaning%3BWinkle%2C+Helen%3BYu%2C+Lawrence&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2010-09-01&rft.volume=12&rft.issue=3&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-010-9201-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-21 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Psychiatry. 1989 Jul;50(7):256-61 [2500425] Sleep Med. 2006 Aug;7(5):397-406 [16815744] Clin Pharmacol Ther. 1999 Sep;66(3):295-305 [10511066] Psychopharmacol Bull. 1991;27(4):637-43 [1813908] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1208/s12248-010-9201-5 ER - TY - GEN T1 - Original Abbreviated New Animal Drug Applications (ANADAs) AN - 751417119 AB - Two drugs approved under the Original Abbreviated New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Drugs KW - FDA approval KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Original+Abbreviated+New+Animal+Drug+Applications+%28ANADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Original New Animal Drug Applications (NADAs): AN - 751417118 AB - Three drugs approved under the Original New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 38 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Original+New+Animal+Drug+Applications+%28NADAs%29%3A&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - "ENFJ Bichon Frise Seeking ISTP Burmese to Share Home with INTJ Human" AN - 751417117 AB - O'Neill talks about different animal behaviors and personality. Personality preferences may be observed among species and breeds. A Golden retriever rescue organization will advertise their adoptees as kind and fun. Equestrians may describe horses as sympathetic and helpful. JF - FDA Veterinarian AU - O'Neill, Gail Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 6 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Animal behavior KW - Veterinary medicine KW - Veterinarians KW - Preferences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=%22ENFJ+Bichon+Frise+Seeking+ISTP+Burmese+to+Share+Home+with+INTJ+Human%22&rft.au=O%27Neill%2C+Gail&rft.aulast=O%27Neill&rft.aufirst=Gail&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Tables; Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Electronic Adverse Drug Event Reporting Goes Global AN - 751417116 AB - In May 2010, FDA and the National Institutes of Health launched the Safety Reporting Portal, a new Web site that gives consumers and regulated industry a way to electronically report information to the US government. Ultimately, portal users will be able to report a variety of safety and health information, but one of the first uses is for adverse drug event reporting. JF - FDA Veterinarian AU - Scheid, Jon Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 14 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Web sites KW - Information KW - Drug use KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Electronic+Adverse+Drug+Event+Reporting+Goes+Global&rft.au=Scheid%2C+Jon&rft.aulast=Scheid&rft.aufirst=Jon&rft.date=2010-08-16&rft.volume=&rft.issue=557&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Illustrations N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Availability of Vetsulin for Critical Needs Dogs and Cats AN - 751417097 AB - On May 5, 2010, Food and Drug Administration (FDA) announces a plan to address concerns regarding the supply of Intervet/Schering Plough Animal Health's (Intervet) Vetsulin (porcine insulin zinc suspension), a product used to treat diabetes in dogs and cats. FDA is allowing Intervet to offer a limited supply of Vetsulin through their Vetsulin Critical-Need Program and the supply is only to be used for a critical-need dog or cat that, in the medical judgment of the pet's veterinarian, cannot be effectively managed on another insulin product. Further, Intervet continues to work with FDA to address concerns associated with the manufacture of Vetsulin such as the varying amounts of crystalline zinc insulin in the formulation that could cause a delay in insulin action and an overall longer duration of insulin activity. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 29 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Dogs KW - Cats KW - Government agencies KW - Diabetes KW - Veterinary medicine KW - Veterinarians KW - Insulin KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Availability+of+Vetsulin+for+Critical+Needs+Dogs+and+Cats&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA; Intervet-Schering-Plough Animal Health N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - CVM Announces the Availability of the NARMS 2007 Executive Report AN - 751417095 AB - On May 4, 2010, US Food and Drug Administration's Center for Veterinary Medicine (CVM) announces the availability of the National Antimicrobial Resistance Monitoring System -- Enteric Bacteria (NARMS) 2007 Executive Report. The report summarizes, in an integrated format, NARMS data on non-typhoidal Salmonella and Campylobacter isolates recovered in 2007 from food animals at federally inspected plants, retail meats, and humans. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 29 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Drug resistance KW - Gram-negative bacteria KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Announces+the+Availability+of+the+NARMS+2007+Executive+Report&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Riding the Wave - Kudos Roll in for Dr. Reimschuessel AN - 751417065 AB - In Nov 2009, the Board of Publications for the journal, Toxicological Sciences, honored Dr. Renate Reimschuessel and her co-authors with the "Best Paper in Toxicological Sciences" award. A collaborative effort by Dr. Reimschuessel, an FDA scientist at CVM's Office of Research, and scientists at Procter and Gamble, the paper describes the research conducted during the height of the 2007 pet food recall because of melamine contamination. JF - FDA Veterinarian AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 8 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Awards & honors KW - Contamination KW - Toxicity KW - Collaboration KW - Veterinarians KW - Reimschuessel, Renate KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Riding+the+Wave+-+Kudos+Roll+in+for+Dr.+Reimschuessel&rft.au=Stamper%2C+Carmela&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs; References N1 - People - Reimschuessel, Renate N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - All Creatures Great and Small: Properly Medicate Them All AN - 751417062 AB - Kim-Jung talks about medication errors. A medication error can occur anywhere in the medication use process, from a practitioner writing a prescription, to a pharmacist filling the prescription, to a nurse giving the drug to a person in the hospital, or to a person taking the drug at home. JF - FDA Veterinarian AU - Kim-Jung, Linda Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Medical errors KW - Education KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=All+Creatures+Great+and+Small%3A+Properly+Medicate+Them+All&rft.au=Kim-Jung%2C+Linda&rft.aulast=Kim-Jung&rft.aufirst=Linda&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Graphs; Tables N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Evamist Hormone Spray May Cause Illness in Pets AN - 751417059 AB - The Center for Veterinary Medicine would like pet owners to know that Evamist (estradiol transdermal spray), a topical hormone replacement product, sprayed on the forearm to reduce hot flashes in women during menopause, has the potential to cause health problems in pets exposed to the product on the owner's skin. In reported cases, the owners had been applying Evamist spray to their forearms. Secondary exposure to the pets likely occurred when the dogs licked the owner's arms, or while the dog was held by the owner. Small pets (dog, cat, pocket pet) may be especially sensitive to the estrogen in Evamist. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 27 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Estrogen KW - Hormone replacement therapy KW - Animal diseases KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Evamist+Hormone+Spray+May+Cause+Illness+in+Pets&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Spotlight On: Dr. Renate Reimschuessel, Office of Research AN - 751417057 AB - In an interview, Dr. Renate Reimschuessel talks about her interest in aquatic animal medicine, her path to Center for Veterinary Medicine (CVM), her research on melamine, and what her future at CVM holds. JF - FDA Veterinarian AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 10 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinarians KW - Veterinary medicine KW - Aquaculture KW - Reimschuessel, Renate KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Spotlight+On%3A+Dr.+Renate+Reimschuessel%2C+Office+of+Research&rft.au=Stamper%2C+Carmela&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs; References N1 - People - Reimschuessel, Renate N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Ask Dr. Dunham: Thoughts on the Human-Animal Bond - An Interview with CVM Director, Dr. Bernadette Dunham AN - 751417053 AB - In an interview, CVM Director, Dr. Bernadette Dunham talks about humans and animals share an ever-growing bond of care and concern commonly called the "human-animal bond." According to Dr. Dunham, humans share this unique bond with animals because of their unwavering loyalty. JF - FDA Veterinarian AU - Saavedra, Lauren Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 5 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Loyalty KW - Emotions KW - Veterinarians KW - Animal behavior KW - Dunham, Bernadette UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Ask+Dr.+Dunham%3A+Thoughts+on+the+Human-Animal+Bond+-+An+Interview+with+CVM+Director%2C+Dr.+Bernadette+Dunham&rft.au=Saavedra%2C+Lauren&rft.aulast=Saavedra&rft.aufirst=Lauren&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - People - Dunham, Bernadette N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Supplemental New Animal Drug Applications (NADAs) AN - 751417042 AB - Two drugs approved under the Supplemental New Animal Drug Applications are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Supplemental+New+Animal+Drug+Applications+%28NADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - CVM Shouts "Hear, Hear!" to Veterinarians around the World AN - 751417040 AB - To honor Claude Bourgelat's legacy and veterinarians worldwide, 2011 has been declared "World Veterinary Year" by 19 countries, including the US. World Veterinary Year, or Vet2011, is a time to raise public awareness about the veterinary profession. JF - FDA Veterinarian AU - Saavedra, Lauren Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 13 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Special events KW - Veterinary medicine KW - Veterinarians KW - Scientists KW - Bourgelat, Claude UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Shouts+%22Hear%2C+Hear%21%22+to+Veterinarians+around+the+World&rft.au=Saavedra%2C+Lauren&rft.aulast=Saavedra&rft.aufirst=Lauren&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - People - Bourgelat, Claude N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA-T.R.A.C.K. AN - 751417039 AB - FDA-Transparency Results Accountability Credibility Knowledge-sharing is a new system used to manage the goals and objectives of program offices in the agency. Launched on April 7, 2010, this new system shows the public how well FDA promotes human and animal health and how well managers use that information to improve FDA's performance. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 15 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Objectives KW - Animal care KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA-T.R.A.C.K.&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Draft Compliance Policy Guide: Salmonella in Animal Feed AN - 751417038 AB - The Food and Drug Administration has published the Notice of Availability of Draft Compliance Policy Guide Section 690.800 Salmonella in Animal Feed in the Federal Register today. The draft CPG, when finalized, will help guide FDA staff's regulatory policy relating to animal feed or feed ingredients that are contaminated with Salmonella and that come in direct contact with humans, such as pet food and pet treats. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Pets KW - Veterinary services KW - Veterinary medicine KW - Salmonella KW - Compliance KW - Food contamination & poisoning KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Draft+Compliance+Policy+Guide%3A+Salmonella+in+Animal+Feed&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - T.A.L.K. Before You Treat AN - 751417036 AB - Steel talks about correctly medicating animals. It requires a proper diagnosis and responsible veterinary treatment. JF - FDA Veterinarian AU - Steel, Ashley AU - McLean, Melanie AU - Greenlees, Kevin AU - Hartogensis, Martine Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 3 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Medical diagnosis KW - Veterinary medicine KW - Medical treatment KW - Animals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=T.A.L.K.+Before+You+Treat&rft.au=Steel%2C+Ashley%3BMcLean%2C+Melanie%3BGreenlees%2C+Kevin%3BHartogensis%2C+Martine&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Antimicrobial Drugs: Judicious Use Fights Resistance AN - 751417035 AB - The FDA's Center for Veterinary Medicine (CVM) draft guidance entitled "The Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals" is discussed. In the draft guidance, CVM states that using medically important antimicrobial drugs to increase production in food-producing animals is not a judicious use. CVM's draft guidance includes recommendations for the judicious use of antimicrobial drugs in food-producing animals. JF - FDA Veterinarian AU - McLean, Melanie AU - Flynn, William AU - Heinz, Diane Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 16 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary services KW - Antibiotics KW - Livestock KW - Drug resistance KW - Public health KW - Public policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Antimicrobial+Drugs%3A+Judicious+Use+Fights+Resistance&rft.au=McLean%2C+Melanie%3BFlynn%2C+William%3BHeinz%2C+Diane&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces FY 2011 Animal Drug User Fees AN - 751417034 AB - The Food and Drug Administration is publishing a notice in the Federal Register on August 3, 2010, announcing the rates and payment procedures for animal drug user fees for fiscal year (FY) 2011. The Animal Drug User Fee Amendments of 2008 (ADUFA II) reauthorizes FDA to collect user fees for certain animal drug applications, products, establishments, sponsors and investigational animal drug submissions. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Drug use KW - Animals KW - Fiscal years KW - Fees & charges KW - Veterinary medicine KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+FY+2011+Animal+Drug+User+Fees&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Test Your Minor Species Knowledge with OMUMS! AN - 751417019 AB - McLean presents facts about minor species ferrets and pheasants. The Center for Veterinary Medicine Office of Minor Use and Minor Species Animal Drug Development works hard to make sure safe and effective drugs are available for ferrets and pheasants. Ferrets belong to the weasel family, and Pheasants are not native to North America. JF - FDA Veterinarian AU - McLean, Melanie AU - Oeller, Margaret Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 23 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Wildfowl KW - Mammals KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Test+Your+Minor+Species+Knowledge+with+OMUMS%21&rft.au=McLean%2C+Melanie%3BOeller%2C+Margaret&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OS&C Helps Develop New Electronic Questionnaire for Pet Food Complaints AN - 751417017 AB - In May 2010, FDA launched the Safety Reporting Portal, an electronic portal that allows consumers and regulated industry to report information to FDA. The Center for Veterinary Medicine Office of Surveillance & Compliance played a key part in developing the questionnaire. The electronic questionnaire, which can be accessed through CVM's Web site, gives consumers a new way to report concerns about pet food to FDA. JF - FDA Veterinarian AU - McLean, Melanie AU - Steinberg, Nadine AU - Nguyen, Quynh Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 21 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Pets KW - Feeds KW - Complaints KW - Veterinary medicine KW - Safety KW - Questionnaires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OS%26amp%3BC+Helps+Develop+New+Electronic+Questionnaire+for+Pet+Food+Complaints&rft.au=McLean%2C+Melanie%3BSteinberg%2C+Nadine%3BNguyen%2C+Quynh&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Supplemental Abbreviated New Animal Drug Application (ANADAs) AN - 751417009 AB - Two drugs approved under the Supplemental Abbreviated New Animal Drug Application are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 39 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Drugs KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Supplemental+Abbreviated+New+Animal+Drug+Application+%28ANADAs%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Be A.W.A.R.E. AN - 751417008 AB - CVM's brochure entitled Online Pet Pharmacies. Protect Yourself and Your Pets: Be A. W. A. R. E. will be available soon from the Federal Citizen's Information Center (FCIC). When the FCIC is ready to ship orders for this brochure, CVM will issue an update containing all of the ordering information. CVM Updates is available at http://www.fda.gov/AnimalVeterinary/NewsEvents/ CVMUpdates/default.htm. And to access the online version of the A.W.A.R.E. visit http://www.fda.gov/AnimalVeterinary/ResourcesforYou/ AnimalHealthLiteracy/ucm203000.htm. JF - FDA Veterinarian AU - Steel, Ashley Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 17 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Web sites KW - Brochures KW - Prescription drugs KW - Animal care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Be+A.W.A.R.E.&rft.au=Steel%2C+Ashley&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Announces Minor Use/Minor Species Grant Program Request for Applications AN - 751417007 AB - The Food and Drug Administration today announced the publication of a Request for Applications for a grant program to support the development of new animal drugs intended for minor species or minor uses in major species. (Major species are horses, dogs, cats, cattle, pigs, turkeys and chickens.) The grant program was established by the Minor Use and Minor Species Animal Health Act of 2004 and funding was authorized to start after finalization of regulations to implement the Designation provisions of the statute. (Section 573 of the Federal Food, Drug & Cosmetic Act) JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 28 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Grants KW - Veterinary medicine KW - Animals KW - Nonnative species KW - Drugs KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Announces+Minor+Use%2FMinor+Species+Grant+Program+Request+for+Applications&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OM, OD, and OS&C Participate in Veterinary Medical Officer Talent Management Advisory Council AN - 751417004 AB - CVM's Office of the Center Director, Office of Surveillance & Compliance, and Office of Management are participating in a government-wide initiative to analyze the federal veterinary workforce and address the needs of this mission-critical occupation. In February 2009, GAO issued two reports stating that the federal government does not sufficiently understand its veterinary workforce and has not adequately identified the needs of this workforce in the event of a national emergency. JF - FDA Veterinarian AU - Cameron AU - Bradbury, Shannon AU - Stamper, Carmela Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 24 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary medicine KW - Veterinarians KW - Talent management KW - Workforce KW - Human resource management KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751417004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=OM%2C+OD%2C+and+OS%26amp%3BC+Participate+in+Veterinary+Medical+Officer+Talent+Management+Advisory+Council&rft.au=Cameron%3BBradbury%2C+Shannon%3BStamper%2C+Carmela&rft.aulast=Cameron&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - OR on the Cutting-Edge of Research AN - 751416981 AB - The Center for Veterinary Medicine Office of Research is working on several cutting-edge scientific projects with biomarkers. The dairy cow and dairy goat projects, conducted by Dr. Jamie Boehmer, and the swine project, run by Dr. Michael Myers, will provide useful information about the inflammatory process in ruminants and pigs. The herding dog breeds project, conducted by Drs. Michael Myers and Haile Yancy, will provide important animal health information for veterinarians and breeders of herding dogs. JF - FDA Veterinarian AU - Stamper, Carmela AU - Myers, Michael AU - Boehmer, Jamie AU - Yancy, Haile AU - Harbottle, Heather Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 22 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Medical research KW - Biomarkers KW - Animal diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=OR+on+the+Cutting-Edge+of+Research&rft.au=Stamper%2C+Carmela%3BMyers%2C+Michael%3BBoehmer%2C+Jamie%3BYancy%2C+Haile%3BHarbottle%2C+Heather&rft.aulast=Stamper&rft.aufirst=Carmela&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - Photographs N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - What's Happening at CVM?: ONADE Participates in Bioequivalence Workshop AN - 751416975 AB - The Center for Veterinary Medicine's Office of New Animal Drug Evaluation (ONADE) participated in an international workshop on bioequivalence issues in veterinary medicine in Potomac, MD from Jun 27, 2010 to Jun 30, 2010. The workshop was hosted by the American Academy of Veterinary Pharmacology & Therapeutics, European College of Veterinary Pharmacology & Toxicology, and European Association for Veterinary Pharmacology & Toxicology. The recent workshop was described by Dr. Martinez, a pharmacologist in ONADE, as a way to explore creative solutions to the complex bioequivalence issues seen in veterinary medicine. JF - FDA Veterinarian AU - McLean, Melanie AU - Martinez, Marilyn Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 20 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinary medicine KW - Drugs KW - Workshops KW - Conferences KW - Animal care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=What%27s+Happening+at+CVM%3F%3A+ONADE+Participates+in+Bioequivalence+Workshop&rft.au=McLean%2C+Melanie%3BMartinez%2C+Marilyn&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - Meet the Office of Foods AN - 751416972 AB - On Aug 18, 2009, the Office of Foods (OF) was created by FDA Commissioner Margaret Hamburg to lead a unified FDA Foods program. OF provides leadership, guidance, and support to the FDA Foods Program. The Executive Leadership Team of the FDA Foods Program includes leaders from OF, Center for Food Safety and Applied Nutrition, Center for Veterinary Medicine, Office of Regulatory Affairs, and Office of the Commissioner. JF - FDA Veterinarian AU - O'Neill, Gail AU - McLean, Melanie Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 19 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Food safety KW - Veterinary services KW - Appointments & personnel changes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Meet+the+Office+of+Foods&rft.au=O%27Neill%2C+Gail%3BMcLean%2C+Melanie&rft.aulast=O%27Neill&rft.aufirst=Gail&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - GRAS Grows at CVM AN - 751416968 AB - Wong et al talk about the FDA's Center for Veterinary Medicine (CVM) voluntary pilot program that changes the way a company may inform CVM that it has made a GRAS (Generally Recognized As Safe) determination. In CVM's pilot program, a company submits a GRAS notice that summarizes the data and information used to support the GRAS determination for the use of a feed ingredient. If the substance will be used in feed for food-producing animals, like cattle, pigs, and chickens, the GRAS notice addresses human food safety. JF - FDA Veterinarian AU - Wong, Geoffrey AU - Dangin, Alfan AU - McLean, Melanie AU - Korb, Lee Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 18 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - FDA approval KW - Food additives KW - Pilot projects KW - Food safety KW - Feeds KW - Veterinary services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=GRAS+Grows+at+CVM&rft.au=Wong%2C+Geoffrey%3BDangin%2C+Alfan%3BMcLean%2C+Melanie%3BKorb%2C+Lee&rft.aulast=Wong&rft.aufirst=Geoffrey&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Document feature - References N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Initiates Rulemaking on Sanitary Food Transportation Act AN - 751416966 AB - On Apr 30, 2010, US Food and Drug Administration's Center for Food Safety and Applied Nutrition (CFSAN) and Center for Veterinary Medicine (CVM) announced an Advance Notice of Proposed Rulemaking (ANPRM) on implementing the Sanitary Food Transportation Act of 2005 (2005 SFTA). The ANPRM is the first step in writing federal regulations that will govern sanitary practices by shippers, carriers by motor vehicle or rail vehicle, receivers, and others engaged in the transportation of food products for humans and animals. The 2005 SFTA also provides broad authority to FDA to regulate the transportation of human and animal food products to protect products from food-safety hazards during transport. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 30 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Government agencies KW - Veterinary medicine KW - Federal legislation KW - Food products KW - Food safety KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Initiates+Rulemaking+on+Sanitary+Food+Transportation+Act&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - GEN T1 - FDA Warns of Salmonella Risk from Frozen Rodents Fed to Reptiles AN - 751416965 AB - The U.S. Food and Drug Administration is warning U.S. and international customers who may have purchased frozen mice from Biggers and Callaham LLC, doing business as MiceDirect, that these products, which are used as food for reptiles, have the potential to be contaminated with Salmonella. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 26 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine IS - 2 KW - Veterinary Science KW - Veterinarians KW - Veterinary medicine KW - Rodents KW - Salmonella KW - Reptiles & amphibians KW - Diet KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/751416965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=FDA+Warns+of+Salmonella+Risk+from+Frozen+Rodents+Fed+to+Reptiles&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-16&rft.volume=&rft.issue=2&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Aug 16, 2010 N1 - Last updated - 2011-06-21 ER - TY - JOUR T1 - Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol. AN - 733974161; 20542088 AB - Oxidative stress and secondary excitotoxicity, due to cellular energy deficit, are major factors playing roles in 3-nitropropionic acid (3-NPA) induced mitochondrial dysfunction. Acute or chronic exposure to 3-NPA also leads to neuronal degeneration in different brain regions. The present study quantitatively assessed peripheral neuropathy induced by chronic exposure to 3-NPA in rats. The neuroprotective abilities of two antioxidants, acetyl-l-carnitine and resveratrol, were investigated as well. Rats were exposed for up to four weeks to 3-NPA alone or 3-NPA combined with acetyl-l-carnitine or resveratrol, administered peripherally. The experimental outcome was evaluated by neurophysiological, histological, and morphometric analyses. Rats exposed to 3-NPA developed hind limb paresis. Furthermore, a significant decrease in motor nerve conduction velocity (MCV) was detected in tail nerves and axonal degeneration in sciatic nerves (p<0.05). Treatment with resveratrol prevented the functional effects of 3-NPA exposure, whereas treatment with acetyl-l-carnitine, preventing paresis, was not effective to MCV and morphological changes. These data suggest that resveratrol is a good candidate for treatment of metabolic neuropathy. The experimental outcome of this study shows that chronic treatment with 3-NPA in rats is relevant in development of an experimental model of toxic neuropathy. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Binienda, Zbigniew K AU - Beaudoin, Micheal A AU - Gough, Bobby AU - Ali, Syed F AU - Virmani, Ashraf AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, AR 72079, USA. zbigniew.binienda@fda.hhs.gov Y1 - 2010/08/16/ PY - 2010 DA - 2010 Aug 16 SP - 117 EP - 121 VL - 480 IS - 2 KW - Antioxidants KW - 0 KW - Environmental Pollutants KW - Neuroprotective Agents KW - Nitro Compounds KW - Propionates KW - Stilbenes KW - Acetylcarnitine KW - 6DH1W9VH8Q KW - resveratrol KW - Q369O8926L KW - 3-nitropropionic acid KW - QY4L0FOX0D KW - Index Medicus KW - Rats KW - Axons -- pathology KW - Animals KW - Rats, Sprague-Dawley KW - Axons -- drug effects KW - Neural Conduction -- drug effects KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Sciatic Nerve -- pathology KW - Sciatic Nerve -- physiopathology KW - Sciatic Nerve -- drug effects KW - Male KW - Acetylcarnitine -- therapeutic use KW - Propionates -- toxicity KW - Nitro Compounds -- toxicity KW - Environmental Pollutants -- toxicity KW - Antioxidants -- pharmacology KW - Stilbenes -- pharmacology KW - Peripheral Nervous System Diseases -- pathology KW - Antioxidants -- therapeutic use KW - Stilbenes -- therapeutic use KW - Acetylcarnitine -- pharmacology KW - Neuroprotective Agents -- therapeutic use KW - Peripheral Nervous System Diseases -- drug therapy KW - Peripheral Nervous System Diseases -- chemically induced KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733974161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Assessment+of+3-nitropropionic+acid-evoked+peripheral+neuropathy+in+rats%3A+neuroprotective+effects+of+acetyl-l-carnitine+and+resveratrol.&rft.au=Binienda%2C+Zbigniew+K%3BBeaudoin%2C+Micheal+A%3BGough%2C+Bobby%3BAli%2C+Syed+F%3BVirmani%2C+Ashraf&rft.aulast=Binienda&rft.aufirst=Zbigniew&rft.date=2010-08-16&rft.volume=480&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2010.06.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-19 N1 - Date created - 2010-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2010.06.020 ER - TY - JOUR T1 - Occupational Trichloroethylene Exposure and Renal Carcinoma Risk: Evidence of Genetic Susceptibility by Reductive Metabolism Gene Variants AN - 877593072; 13651112 AB - Trichloroethylene (TCE) is a suspected renal carcinogen. TCE-associated renal genotoxicity occurs predominantly through glutathione S-transferase (GST) conjugation and bioactivation by renal cysteine b-lyase (CCBL1). We conducted a case-control study in Central Europe (1,097 cases and 1,476 controls) specifically designed to assess risk associated with occupational exposure to TCE through analysis of detailed job histories. All jobs were coded for organic/chlorinated solvent and TCE exposure (ever/never) as well as the frequency and intensity of exposure based on detailed occupational questionnaires, specialized questionnaires, and expert assessments. Increased risk was observed among subjects ever TCE exposed [odds ratio (OR) = 1.63; 95% confidence interval (95% CI), 1.04-2.54]. Exposure-response trends were observed among subjects above and below the median exposure [average intensity (OR = 1.38; 95% CI, 0.81-2.35; OR = 2.34; 95% CI, 1.05-5.21; Ptrend = 0.02)]. A significant association was found among TCE-exposed subjects with at least one intact GSTT1 allele (active genotype; OR = 1.88; 95% CI, 1.06-3.33) but not among subjects with two deleted alleles (null genotype; OR = 0.93; 95% CI, 0.35-2.44; Pinteraction = 0.18). Similar associations for all exposure metrics including average intensity were observed among GSTT1-active subjects (OR = 1.56; 95% CI, 0.79-3.10; OR = 2.77; 95% CI, 1.01-7.58; Ptrend = 0.02) but not among GSTT1 nulls (OR = 0.81; 95% CI, 0.24-2.72; OR = 1.16; 95% CI, 0.27-5.04; Ptrend = 1.00; Pinteraction = 0.34). Further evidence of heterogeneity was seen among TCE-exposed subjects with .1 minor allele of several CCBL1-tagging single nucleotide polymorphisms: rs2293968, rs2280841, rs2259043, and rs941960. These findings provide the strongest evidence to date that TCE exposure is associated with increased renal cancer risk, particularly among individuals carrying polymorphisms in genes that are important in the reductive metabolism of this chemical, and provides biological plausibility of the association in humans. Cancer Res; 70(16); 6527-36. [copy ]2010 AACR. JF - Cancer Research AU - Moore, Lee E AU - Boffetta, Paolo AU - Karami, Sara AU - Brennan, Paul AU - Stewart, Patricia S AU - Hung, Rayjean AU - Zaridze, David AU - Matveev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Helena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonila AU - Mates, Dana AU - Gromiec, Jan AU - Holcatova, Ivana AU - Merino, Maria AU - Chanock, Stephen AU - Chow, Wong-Ho AU - Rothman, Nathaniel AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics and Core Genotyping Facility at the Advanced Technology Center of the National Cancer Institute, NIH, Department of Health and Human Services Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 6527 EP - 6536 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 70 IS - 16 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts KW - Inventories KW - GSTT1 protein KW - Gene polymorphism KW - Genotoxicity KW - Solvents KW - Carcinogens KW - Glutathione transferase KW - Cancer KW - renal cell carcinoma KW - Cysteine KW - Single-nucleotide polymorphism KW - Dose-response effects KW - Kidney KW - Trichloroethylene KW - Metabolism KW - Occupational exposure KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877593072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Occupational+Trichloroethylene+Exposure+and+Renal+Carcinoma+Risk%3A+Evidence+of+Genetic+Susceptibility+by+Reductive+Metabolism+Gene+Variants&rft.au=Moore%2C+Lee+E%3BBoffetta%2C+Paolo%3BKarami%2C+Sara%3BBrennan%2C+Paul%3BStewart%2C+Patricia+S%3BHung%2C+Rayjean%3BZaridze%2C+David%3BMatveev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Helena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonila%3BMates%2C+Dana%3BGromiec%2C+Jan%3BHolcatova%2C+Ivana%3BMerino%2C+Maria%3BChanock%2C+Stephen%3BChow%2C+Wong-Ho%3BRothman%2C+Nathaniel&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2010-08-15&rft.volume=70&rft.issue=16&rft.spage=6527&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inventories; GSTT1 protein; Gene polymorphism; Genotoxicity; Solvents; Carcinogens; Glutathione transferase; Cancer; renal cell carcinoma; Single-nucleotide polymorphism; Cysteine; Dose-response effects; Kidney; Trichloroethylene; Occupational exposure; Metabolism ER - TY - JOUR T1 - Scombroid poisoning: A review AN - 760207940; 13204119 AB - Scombroid poisoning, also called histamine fish poisoning, is an allergy-like form of food poisoning that continues to be a major problem in seafood safety. The exact role of histamine in scombroid poisoning is not straightforward. Deviations from the expected dose-response have led to the advancement of various possible mechanisms of toxicity, none of them proven. Histamine action levels are used in regulation until more is known about the mechanism of scombroid poisoning. Scombroid poisoning and histamine are correlated but complicated. Victims of scombroid poisoning respond well to antihistamines, and chemical analyses of fish implicated in scombroid poisoning generally reveal elevated levels of histamine. Scombroid poisoning is unique among the seafood toxins since it results from product mishandling rather than contamination from other trophic levels. Inadequate cooling following harvest promotes bacterial histamine production, and can result in outbreaks of scombroid poisoning. Fish with high levels of free histidine, the enzyme substrate converted to histamine by bacterial histidine decarboxylase, are those most often implicated in scombroid poisoning. Laboratory methods and screening methods for detecting histamine are available in abundance, but need to be compared and validated to harmonize testing. Successful field testing, including dockside or on-board testing needed to augment HACCP efforts will have to integrate rapid and simplified detection methods with simplified and rapid sampling and extraction. Otherwise, time-consuming sample preparation reduces the impact of gains in detection speed on the overall analysis time. JF - Toxicon AU - Hungerford, James M AD - ATC, PRL-NW, USFDA, 22201 23rd Dr S.E. Bothell, WA 98021, United States, James.Hungerford@fda.hhs.fda.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 231 EP - 243 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Scombroid poisoning KW - Histamine KW - Scombrotoxin KW - Seafood safety KW - Test kits KW - Dockside testing KW - Histidine decarboxylase KW - Toxicants KW - Abundance KW - Pollution effects KW - Public health KW - Laboratory methods KW - histamines KW - Dose-response effects KW - Sampling KW - Seafood KW - Histamines KW - Screening KW - Antihistamines KW - Poisoning KW - Enzymes KW - Food poisoning KW - Toxicity KW - Food contamination KW - Trophic levels KW - Toxins KW - Literature reviews KW - Reviews KW - Histidine KW - Fish poisoning KW - Fish KW - Chemical analysis KW - Q1 08482:Ecosystems and energetics KW - Q5 08504:Effects on organisms KW - X 24320:Food Additives & Contaminants KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Scombroid+poisoning%3A+A+review&rft.au=Hungerford%2C+James+M&rft.aulast=Hungerford&rft.aufirst=James&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Screening; Literature reviews; Toxicants; Fish poisoning; Pollution effects; Toxicity; Seafood; Histamines; Chemical analysis; Public health; Histidine decarboxylase; Antihistamines; Abundance; Poisoning; Food poisoning; Enzymes; Food contamination; Toxins; Trophic levels; Histamine; Histidine; Reviews; Sampling; Laboratory methods; histamines; Dose-response effects; Fish DO - http://dx.doi.org/10.1016/j.toxicon.2010.02.006 ER - TY - JOUR T1 - Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish AN - 760207546; 13204169 AB - Herein, we describe advancements in monitoring of brevetoxins in molluscan shellfish, with respect to exposure management and control of neurotoxic shellfish poisoning (NSP). Current knowledge of the fate of brevetoxins in molluscan shellfish, and the toxic potency of brevetoxin metabolites, is presented. We review rapid assays for measuring composite brevetoxins, and methodology for measuring constituent brevetoxins, in contaminated shellfish. The applicability of in vitro methods for estimating brevetoxin burden and composite toxicity in shellfish is assessed. Specific and measurable biomarkers of brevetoxin exposure and toxicity in shellfish, and of human intoxication, are described. Their utility in regulatory monitoring of toxic shellfish and in clinical diagnosis of NSP is evaluated. JF - Toxicon AU - Plakas, Steven M AU - Dickey, Robert W AD - Gulf Coast Seafood Laboratory, U.S. Food and Drug Administration, 1 Iberville Drive, Dauphin Island, AL 36528, USA, Steven.Plakas@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 137 EP - 149 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Brevetoxins KW - Neurotoxic shellfish poisoning KW - Monitoring KW - Shellfish KW - Intoxication KW - Pollution monitoring KW - Poisoning KW - Metabolites KW - Toxicity KW - Biomarkers KW - biomarkers KW - Toxicity tests KW - Bioaccumulation KW - Reviews KW - Neurotoxicity KW - Mollusca KW - Pollution indicators KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08266:Physiology, biochemistry, biophysics KW - X 24370:Natural Toxins KW - Q5 08502:Methods and instruments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Advances+in+monitoring+and+toxicity+assessment+of+brevetoxins+in+molluscan+shellfish&rft.au=Plakas%2C+Steven+M%3BDickey%2C+Robert+W&rft.aulast=Plakas&rft.aufirst=Steven&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Bioaccumulation; Shellfish; Biomarkers; Toxicity; Pollution indicators; Toxicity tests; Intoxication; Brevetoxins; Reviews; Neurotoxicity; Poisoning; Metabolites; biomarkers; Mollusca DO - http://dx.doi.org/10.1016/j.toxicon.2009.11.007 ER - TY - JOUR T1 - Ciguatera: A public health perspective AN - 760207022; 13204170 AB - Ciguatera fish poisoning is a seafood-borne illness caused by consumption of fish that have accumulated lipid-soluble ciguatoxins. In the United States, ciguatera is responsible for the highest reported incidence of food-borne illness outbreaks attributed to finfish, and it is reported to hold this distinction globally. Ciguatoxins traverse the marine food web from primary producers, Gambierdiscus spp., to commonly consumed fish in tropical and subtropical regions of the world. Ciguatoxins comprise 12 known congeners among Caribbean and tropical Atlantic fish and 29 reported congeners among Pacific fish. Expanding trade in fisheries from ciguatera-endemic regions contributes to wider distribution and increasing frequency of disease among seafood consumers in non-endemic regions. Ciguatoxins produce a complex array of gastrointestinal, neurological and cardiological symptoms. Treatment options are very limited and supportive in nature. Information derived from the study of ciguatera outbreaks has improved clinical recognition, confirmation, and timely treatment. Such studies are equally important for the differentiation of ciguatoxin profiles in fish from one region to the next, the determination of toxicity thresholds in humans, and the formulation of safety limits. Analytical information from case and outbreak investigations was used to derive Pacific and Caribbean ciguatoxin threshold contamination rates for adverse effects in seafood consumers. To these threshold estimates 10-fold safety factors were applied to address individual human risk factors; uncertainty in the amount of fish consumed; and analytical accuracy. The studies may serve as the basis for industry and consumer advisory levels of 0.10ppb C-CTX-1 equivalent toxicity in fish from the tropical Atlantic, Gulf of Mexico, Caribbean, and 0.01ppb P-CTX-1 equivalent toxicity in fish from Pacific regions. JF - Toxicon AU - Dickey, Robert W AU - Plakas, Steven M AD - U.S. FDA Center for Food Safety and Applied Nutrition, Office of Food Safety, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA, robert.dickey@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 123 EP - 136 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Ciguatera KW - Ciguatoxins KW - Food KW - Threshold limits KW - Disease control KW - Toxicity tests KW - Public health KW - Differentiation KW - ASW, Caribbean Sea KW - Risk factors KW - Fisheries KW - Congeners KW - Consumers KW - Seafood KW - Pollution indicators KW - Food webs KW - Gambierdiscus KW - Poisoning KW - Toxicity KW - Food contamination KW - AS, Tropical Atlantic KW - ASW, Mexico Gulf KW - USA KW - Bioaccumulation KW - Ciguatoxin KW - Side effects KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08484:Species interactions: parasites and diseases KW - X 24320:Food Additives & Contaminants KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760207022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Ciguatera%3A+A+public+health+perspective&rft.au=Dickey%2C+Robert+W%3BPlakas%2C+Steven+M&rft.aulast=Dickey&rft.aufirst=Robert&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Bioaccumulation; Disease control; Consumers; Seafood; Ciguatoxin; Pollution indicators; Toxicity tests; Public health; Ciguatera; Food; Threshold limits; Poisoning; Toxicity; Food contamination; Differentiation; Risk factors; Fisheries; Congeners; Side effects; Food webs; Gambierdiscus; ASW, Mexico Gulf; USA; ASW, Caribbean Sea; AS, Tropical Atlantic DO - http://dx.doi.org/10.1016/j.toxicon.2009.09.008 ER - TY - JOUR T1 - Human risk associated with palytoxin exposure AN - 760206999; 13204168 AB - Palytoxin (PTX) was first isolated from the zoanthid Palythoa toxica. Evaluation of PTX toxicity using various animal models determined that PTX was extremely potent through intravenous, intraperitoneal, and intratracheal exposure. PTX was less potent by direct intragastric exposure. PTX also caused significant, non-lethal effects through dermal and ocular exposure. PTX and PTX-like compounds have now been found in additional zoanthid species, red alga, a sea anemone, and several dinoflagellates. PTXs are found throughout certain reef associated food webs, including in fish and crabs responsible for human illness and death. Many of the organisms found to contain PTXs in the environment are also sold in the home aquarium trade, and recent evidence suggests poisonings have occurred through exposure to these organisms. Due to co-occurrence with other seafood toxins, such as ciguatoxins, saxitoxins, and tetrodotoxin, it has been difficult to assess the true risk of PTX poisoning through seafood consumption in humans, but limited cases have been well documented, some involving human fatalities. Recent evidence also suggests that humans are negatively impacted through PTX exposure by inhalation and dermal routes. Continued research into the distribution and occurrence of PTX and PTX-like compounds both in seafood and marine organisms sold in the aquarium trade appears warranted. JF - Toxicon AU - Deeds, Jonathan R AU - Schwartz, Michael D AD - US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 150 EP - 162 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Pollution Abstracts; Toxicology Abstracts KW - Palytoxin KW - Seafood poisoning KW - Exposure risks KW - Marine aerosols KW - Aquarium zoanthids KW - Inhalation KW - Reefs KW - Toxicants KW - Animal models KW - Tetrodotoxin KW - Toxicity tests KW - Risks KW - Saxitoxin KW - Dinoflagellates KW - Seafood KW - food webs KW - Trachea KW - Pollution indicators KW - Marine crustaceans KW - Food webs KW - Marine KW - Mortality KW - Intravenous administration KW - Skin KW - Decapoda KW - Crustacea KW - Aquatic plants KW - Poisoning KW - Toxicity KW - Toxins KW - Marine organisms KW - Palythoa toxica KW - Fish KW - Ciguatoxin KW - Q5 08503:Characteristics, behavior and fate KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08482:Ecosystems and energetics KW - P 1000:MARINE POLLUTION KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760206999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Human+risk+associated+with+palytoxin+exposure&rft.au=Deeds%2C+Jonathan+R%3BSchwartz%2C+Michael+D&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.05.035 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Toxicants; Ciguatoxin; Toxicity; Seafood; Marine crustaceans; Pollution indicators; Toxicity tests; Food webs; Risks; Inhalation; Reefs; Intravenous administration; Skin; Poisoning; Animal models; Tetrodotoxin; Toxins; Palytoxin; Dinoflagellates; Saxitoxin; Marine organisms; Trachea; Mortality; Crustacea; Aquatic plants; Fish; food webs; Decapoda; Palythoa toxica; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2009.05.035 ER - TY - JOUR T1 - Paralytic shellfish poisoning: Seafood safety and human health perspectives AN - 760206471; 13204171 AB - Paralytic shellfish poisoning (PSP) is the foodborne illness associated with the consumption of seafood products contaminated with the neurotoxins known collectively as saxitoxins (STXs). This family of neurotoxins binds to voltage-gated sodium channels, thereby attenuating action potentials by preventing the passage of sodium ions across the membrane. Symptoms include tingling, numbness, headaches, weakness and difficulty breathing. Medical treatment is to provide respiratory support, without which the prognosis can be fatal. To protect human health, seafood harvesting bans are in effect when toxins exceed a safe action level (typically 80 mu g STX eq 100 g super(-1) tissue). Though worldwide fatalities have occurred, successful management and monitoring programs have minimized PSP cases and associated deaths. Much is known about the toxin sources, primarily certain dinoflagellate species, and there is extensive information on toxin transfer to traditional vectors - filter-feeding molluscan bivalves. Non-traditional vectors, such as puffer fish and lobster, may also pose a risk. Rapid and reliable detection methods are critical for toxin monitoring in a wide range of matrices, and these methods must be appropriately validated for regulatory purposes. This paper highlights PSP seafood safety concerns, documented human cases, applied detection methods as well as monitoring and management strategies for preventing PSP-contaminated seafood products from entering the food supply. JF - Toxicon AU - Etheridge, Stacey M AD - U.S. FDA, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Analytical Chemistry, 5100 Paint Branch Parkway, HFS-707, College Park, MD 20740, USA, Stacey.etheridge@fda.hhs.gov Y1 - 2010/08/15/ PY - 2010 DA - 2010 Aug 15 SP - 108 EP - 122 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 56 IS - 2 SN - 0041-0101, 0041-0101 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Paralytic shellfish poisoning KW - Saxitoxin KW - Dinoflagellates KW - Seafood KW - Shellfish KW - Puffer fish KW - Lobster KW - Detection methods KW - Monitoring KW - Management KW - Urine KW - Serum KW - Symptoms KW - Sodium channels (voltage-gated) KW - Toxicants KW - Food KW - Respiration KW - Public health KW - Expression vectors KW - Action potential KW - Headache KW - Homarus americanus KW - Mortality KW - Ions KW - Food supply KW - Poisoning KW - Prognosis KW - Toxicity KW - Toxins KW - Sodium KW - Fish KW - Neurotoxins KW - Harvesting KW - Metabolism KW - Q5 08503:Characteristics, behavior and fate KW - Q1 08342:Geographical distribution KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760206471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Paralytic+shellfish+poisoning%3A+Seafood+safety+and+human+health+perspectives&rft.au=Etheridge%2C+Stacey+M&rft.aulast=Etheridge&rft.aufirst=Stacey&rft.date=2010-08-15&rft.volume=56&rft.issue=2&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2009.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Symptoms; Toxicants; Respiration; Toxicity; Seafood; Neurotoxins; Metabolism; Paralytic shellfish poisoning; Public health; Ions; Sodium channels (voltage-gated); Food; Prognosis; Expression vectors; Action potential; Headache; Dinoflagellates; Saxitoxin; Harvesting; Sodium; Mortality; Food supply; Poisoning; Fish; Shellfish; Toxins; Homarus americanus DO - http://dx.doi.org/10.1016/j.toxicon.2009.12.013 ER - TY - JOUR T1 - Comparative hepatotoxicity of deoxynivalenol in rat, mouse and human liver cells in culture AN - 883015431; 15241957 AB - The present study was undertaken to assess, in vitro, the hepatotoxic potential of the food-borne mycotoxin, deoxynivalenol (DON), using rat (Clone9 and MH1C1), mouse (NBL CL2) and human (WRL68 and HepG2) liver cells in culture. The cells were treated with DON for 24 h at 37 degree C in 5% CO2 at concentrations of 0-25 mu g ml-1. Following the treatment period, the cells were assayed for biochemical markers of hepatotoxicity that included three independent cytotoxicity assays, oxidative stress and mitochondrial dysfunction. Concentration-dependent cytotoxicity of DON was observed in each of the five different liver cells derived from three different species (rat, mouse and human) over the entire concentration range studied, beginning at 0.1 mu g ml-1. At these concentrations DON did not induce a biologically significant increase in oxidative stress in these liver cells, and showed a significant decrease in the mitochondrial function only in the rat liver MH1C1 cells compared with the control. The results of this in vitro study suggest that DON is a potential hepatotoxin for the rat, mouse and human liver cells in the concentration range tested in this study. The liver cells used in this study showed distinct endpoint-sensitivity to DON related to the species. Published in 2010 by John Wiley and Sons, Ltd. JF - Journal of Applied Toxicology AU - Sahu, Saura C AU - O'Donnell Jr, Michael W AU - Wiesenfeld, Paddy L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Office of Food Defense, Communication and Emergency Response, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA, saura.sahu@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 566 EP - 573 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 6 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Biochemical markers KW - Biochemistry KW - Hepatocytes KW - Food KW - Mitochondria KW - Cell culture KW - oxidative stress KW - hepatotoxicity KW - Cytotoxicity KW - Mycotoxins KW - Vomitoxin KW - Oxidative stress KW - Liver KW - Carbon dioxide KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - X 24370:Natural Toxins KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883015431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Comparative+hepatotoxicity+of+deoxynivalenol+in+rat%2C+mouse+and+human+liver+cells+in+culture&rft.au=Sahu%2C+Saura+C%3BO%27Donnell+Jr%2C+Michael+W%3BWiesenfeld%2C+Paddy+L&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2010-08-01&rft.volume=30&rft.issue=6&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1527 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1527/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Biochemical markers; Mycotoxins; Cytotoxicity; Vomitoxin; Oxidative stress; Hepatocytes; Food; Mitochondria; Cell culture; Carbon dioxide; hepatotoxicity; Biochemistry; Liver; oxidative stress DO - http://dx.doi.org/10.1002/jat.1527 ER - TY - RPRT T1 - Table of contents AN - 878683490 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=547&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE MULTIGENERATIONAL REPRODUCTIVE TOXICOLOGY STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDIES) AN - 878683489; 21031005 AB - Ethinyl estradiol is a potent synthetic estrogen that is widely prescribed in oral contraceptives and is also used in the treatment of breast and prostate cancer. Ethinyl estradiol is one of a class of chemicals known as "environmental estrogens" which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats and their offspring were exposed to ethinyl estradiol over the course of four generations. The continuous-breeding study began with groups of 35 Sprague-Dawley rats of each sex exposed to ethinyl estradiol in their feed at concentrations of 2, 10, or 50 parts per billion (ppb). Control animals received the same feed with no ethinyl estradiol added. Animals from the same dose treatment groups were paired and mated, and 25 litters of pups at each exposure concentration (culled to four males and four females each) were continued on study and given feed containing the same concentration of ethinyl estradiol. The process was repeated through a second and third generation, after which the pups were given control feed only, and two more generations were bred in the same manner and given control feed without ethinyl estradiol. Measures of fertility and reproduction were taken for each generation and tissues from the study animals were examined histopathologically. In all three offspring generations the time to vaginal opening (a measure of onset of puberty) was accelerated in females fed 50 ppb ethinyl estradiol. In the first two offspring generations the estrous cycles of the exposed females were prolonged or aberrant prior to mating. Male rats exposed to ethinyl estradiol had increased rates of mammary gland hyperplasia and mineralization of the kidney tubules. We conclude that exposure to trace amounts of ethinyl estradiol in the feed showed clear biological activity in male and female rats, including reduced body weights in both sexes, perturbed estrous cycles in females, and induction of mammary gland hyperplasia and kidney tubule mineralization in males. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 EP - 312 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Ethinyl Estradiol KW - Studies KW - Estrogen KW - Breeding of animals KW - Chemicals KW - Fertility KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Male KW - Female KW - Pregnancy KW - Organ Size -- drug effects KW - Fetus -- drug effects KW - Reproduction -- drug effects KW - Ethinyl Estradiol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+MULTIGENERATIONAL+REPRODUCTIVE+TOXICOLOGY+STUDY+OF+ETHINYL+ESTRADIOL+%28CAS+NO.+57-63-6%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=547&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Document feature - Equations; Tables; References N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Safety and U.S. Regulatory Considerations in the Nonclinical Use of Medical Ultrasound Devices AN - 853478787; 13714430 AB - Ultrasound imaging has been used for medical purposes for over 50 years and has an excellent safety record. Ultrasonic fetal scanning is generally considered safe and is properly used when medical information on a pregnancy is needed. However, ultrasound energy delivered to the fetus cannot be regarded as completely innocuous. Even though there are no demonstrated risks from ultrasound imaging, it can produce effects on the body. Laboratory studies have demonstrated that diagnostic levels of ultrasound can produce physical effects in tissue, such as mechanical vibrations, rise in temperature and cavitation. A number of in vitro and in vivo (animal and human) biologic effects have been reported following exposure to diagnostic ultrasound devices and low intensity ultrasound used for therapeutic purposes. Most public health experts, clinicians and industry agree that exposure of the fetus to ultrasound for nonmedical purposes should be avoided. The U.S. Food and Drug Administration (FDA) supports this position. JF - Ultrasound in Medicine & Biology AU - Phillips, Robert A AU - Stratmeyer, Mel E AU - Harris, Gerald R AD - U.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, MD, USA, gerald.harris@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1224 EP - 1228 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 36 IS - 8 SN - 0301-5629, 0301-5629 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Therapeutic applications KW - imaging KW - Fetuses KW - Public health KW - Pregnancy KW - Vibrations KW - Scanning KW - Cavitation KW - Ultrasonics KW - Energy KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853478787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Safety+and+U.S.+Regulatory+Considerations+in+the+Nonclinical+Use+of+Medical+Ultrasound+Devices&rft.au=Phillips%2C+Robert+A%3BStratmeyer%2C+Mel+E%3BHarris%2C+Gerald+R&rft.aulast=Phillips&rft.aufirst=Robert&rft.date=2010-08-01&rft.volume=36&rft.issue=8&rft.spage=1224&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2010.03.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Temperature effects; Vibrations; Cavitation; Scanning; Ultrasonics; Energy; Therapeutic applications; imaging; Ultrasound; Fetuses; Pregnancy; Public health DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2010.03.020 ER - TY - JOUR T1 - Isolation and Identification of Three Thio-sildenafil Analogues in Dietary Supplements AN - 839681421; 14016843 AB - Three compounds were found to have been illegally added to dietary supplements marketed for erectile dysfunction. The structures of these compounds were identified with NMR, HRMS, IR, UV and LC/MS/MS, after comparison with the structure of silde-nafil, data showed that the oxygen atom of the carbonyl group in the heterocyclic ring had been replaced with a sulfur atom, these thio-sildenafil analogues were identified as thiosildenafil, thiohomosildenafil and hydroxythiohomosildenafil. Since their structures were similar to that of sildenafil, according to structure-activity relationship, the side effects of these analogues might also associate with that of sildenafil. In accordance with this finding, thio-sildenafil analogues have been included in the inspection list of illegal adulterants in Taiwan. From January to October 2009, thiosildenafil was detected in 6 samples, thiohomosildenafil was detected in 4 samples and hydroxythiohomosildenafil was detected in 3 samples. JF - Journal of Food and Drug Analysis AU - Lai, K-C AU - Liu, Y-C AU - Liao, Y-C AU - Lin, Y-L AU - Tsai, L-Y AU - Lin, J-H AU - Lo, C-F AD - Food and Drug Administration, Department of Health, Executive Yuan 161-2, Kuen Yang Street, Nan-kang 115, Taipei, Taiwan, ROC, cflo@fda.gov.tw Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 269 EP - 278 VL - 18 IS - 4 SN - 1021-9498, 1021-9498 KW - Toxicology Abstracts KW - Sulfur KW - Oxygen KW - Data processing KW - Dietary supplements KW - Sildenafil KW - N.M.R. KW - carbonyls KW - Structure-activity relationships KW - Side effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839681421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+and+Drug+Analysis&rft.atitle=Isolation+and+Identification+of+Three+Thio-sildenafil+Analogues+in+Dietary+Supplements&rft.au=Lai%2C+K-C%3BLiu%2C+Y-C%3BLiao%2C+Y-C%3BLin%2C+Y-L%3BTsai%2C+L-Y%3BLin%2C+J-H%3BLo%2C+C-F&rft.aulast=Lai&rft.aufirst=K-C&rft.date=2010-08-01&rft.volume=18&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+and+Drug+Analysis&rft.issn=10219498&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Sulfur; Oxygen; Data processing; Dietary supplements; N.M.R.; Sildenafil; Structure-activity relationships; carbonyls; Side effects ER - TY - JOUR T1 - Effect of media, additives, and incubation conditions on the recovery of high pressure and heat-injured Clostridium botulinum spores AN - 760202020; 13200308 AB - The effect of additives and post-treatment incubation conditions on the recovery of high pressure and heat-injured (i.e., processed at 620MPa and 95 and 100 degree C for 5min) spores of Clostridium botulinum strains, 62-A (proteolytic type A) and 17-B (nonproteolytic type B) was studied. High pressure and heat-injured spores were inoculated into TPGY (Trypticase-Peptone-Glucosea "Yeast extract) anaerobic broth media containing additives (lysozyme, l-alanine, l-aspartic acid, dipicolonic acid, sodium bicarbonate, and sodium lactate) at various concentrations (0-10 mu g/ml) individually or in combination. The spore counts of high pressure and heat-injured 62-A and 17-B recovered from TPGY broth containing lysozyme (10 mu g/ml) incubated for 4 months versus that recovered from peptone-yeast extract-glucose-starch (PYGS) plating agar containing lysozyme (10 mu g/ml) incubated under anaerobic conditions for 5 days were also compared. None of the additives either individually or in combination in TPGY broth improved recovery of injured spore enumeration compared to processed controls without additives. Addition of lysozyme at concentrations of 5 and 10 mu g/ml in TPGY broth improved initial recovery of injured spores of 17-B during the first 4 days of incubation but did not result in additional recovery at the end of the 4 month incubation compared to the processed control without lysozyme. Adding lysozyme at a concentration of 10 mu g/ml to PYGS plating agar resulted in no effect on the recovery of high pressure and heat-injured 62-A and 17-B spores. The recovery counts of high pressure and heat-injured spores of 62-A and 17-B were lower (i.e., <1.0log units) with PYGS plating agar compared to the MPN method using TPGY broth as the growth medium. JF - Food Microbiology AU - Reddy, N R AU - Tetzloff, R C AU - Skinner, GE AD - National Center for Food Safety and Technology, U.S. Food and Drug Administration, 6502 S. Archer Road, Summit-Argo, IL 60501, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 613 EP - 617 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 27 IS - 5 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clostridium botulinum KW - High pressure processing KW - Recovery of spores KW - Proteolysis KW - Lysozyme KW - Agar KW - Aspartic acid KW - L-Alanine KW - Sodium lactate KW - Spores KW - Pressure KW - Anaerobic conditions KW - Sodium bicarbonate KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/760202020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Effect+of+media%2C+additives%2C+and+incubation+conditions+on+the+recovery+of+high+pressure+and+heat-injured+Clostridium+botulinum+spores&rft.au=Reddy%2C+N+R%3BTetzloff%2C+R+C%3BSkinner%2C+GE&rft.aulast=Reddy&rft.aufirst=N&rft.date=2010-08-01&rft.volume=27&rft.issue=5&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2010.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Proteolysis; Agar; Lysozyme; Aspartic acid; L-Alanine; Sodium lactate; Anaerobic conditions; Pressure; Spores; Sodium bicarbonate; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.fm.2010.02.004 ER - TY - JOUR T1 - Characterization of Listeria monocytogenes Recovered from Imported Cheese Contributed to the National PulseNet Database by the U.S. Food and Drug Administration from 2001 to 2008 AN - 759316676; 13703886 AB - Imported foods must meet the same U.S. Food and Drug Administration (FDA) standards as domestic foods. The FDA determines whether an imported food is in compliance with the Federal Food, Drug, and Cosmetic Act. Pursuant to its regulatory activities, the FDA conducts compliance surveillance on imported foods offered for entry into the U.S. commerce. The National PulseNet Database is the molecular surveillance network for foodborne infections and is widely used to provide real-time subtyping support to epidemiologic investigations of foodborne diseases. FDA laboratories use pulsed-field gel electrophoresis to subtype foodborne pathogens recovered from imported foods and submit the molecular patterns to the National PulseNet Database at the Centers for Disease Control and Prevention. There were 60 isolates of Listeria monocytogenes in the FDA Field Accomplishment and Compliance Tracking System from 2001 to 2008 due to cheese imported from the following countries: Mexico (n = 21 isolates), Italy (19), Israel (9), Portugal (5), Colombia (3), Greece (2), and Spain (1). We observed genetic diversity of L. monocytogenes isolates and genetic relatedness among strains recovered from imported cheese products coming to the United States from different countries. Consistent characterization of L. monocytogenes isolates recovered from imported cheeses, accompanied by epidemiologic investigations to ascertain human illness associated with these strains, could be helpful in the control of listeriosis acquired from imported cheeses. JF - Journal of Food Protection AU - Timbo, Babgaleh B AU - Keys, Christine AU - Klontz, Karl AD - Office of Food Defense, Communication and Emergency Response, and 2 Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, USA, babgaleh.timbo@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1511 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 73 IS - 8 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Portugal KW - Greece KW - Listeriosis KW - Spain KW - Compliance KW - Dairy products KW - Disease control KW - Cosmetics KW - Israel KW - Colombia KW - Cheese KW - Infection KW - food-borne diseases KW - Italy KW - Computer programs KW - prevention KW - Drugs KW - Listeria monocytogenes KW - genetic diversity KW - Pathogens KW - Food contamination KW - Databases KW - USA KW - Mexico KW - FDA KW - Pulsed-field gel electrophoresis KW - J 02310:Genetics & Taxonomy KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759316676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Characterization+of+Listeria+monocytogenes+Recovered+from+Imported+Cheese+Contributed+to+the+National+PulseNet+Database+by+the+U.S.+Food+and+Drug+Administration+from+2001+to+2008&rft.au=Timbo%2C+Babgaleh+B%3BKeys%2C+Christine%3BKlontz%2C+Karl&rft.aulast=Timbo&rft.aufirst=Babgaleh&rft.date=2010-08-01&rft.volume=73&rft.issue=8&rft.spage=1511&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Number of references - 13 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Listeriosis; Pulsed-field gel electrophoresis; Disease control; Cosmetics; Pathogens; Infection; Cheese; Compliance; prevention; Dairy products; FDA; genetic diversity; Food contamination; food-borne diseases; Drugs; Listeria monocytogenes; Portugal; USA; Mexico; Greece; Spain; Israel; Colombia; Italy ER - TY - JOUR T1 - Effect of Exhaled Moisture on Breathing Resistance of N95 Filtering Facepiece Respirators AN - 759313630; 13650200 AB - This study evaluated the effect of exhaled moisture on the breathing resistance of three classes of filtering facepiece respirators (FFR) following 4 h of continuous wear at a breathing volume of 40 l min-1, utilizing an automated breathing and metabolic simulator as a human surrogate. After 4 h, inhalation and exhalation resistance increased by 0.43 and 0.23 mm of H2O pressure, respectively, and average moisture retention in the respirators was 0.26 ml. Under ambient conditions similar to those of the current study, and at similar breathing volumes, it is unlikely that exhaled moisture will add significantly to the breathing resistance of filtering facepiece respirators (FFR) over 4 h of use. JF - Annals of Occupational Hygiene AU - Roberge, Raymond J AU - Bayer, Emily AU - Powell, Jeffrey B AU - Coca, Aitor AU - Roberge, Marc R AU - Benson, Stacey M AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA 15236, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 671 EP - 677 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 6 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Inhalation KW - Respirators KW - Protective equipment KW - wear KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759313630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Effect+of+Exhaled+Moisture+on+Breathing+Resistance+of+N95+Filtering+Facepiece+Respirators&rft.au=Roberge%2C+Raymond+J%3BBayer%2C+Emily%3BPowell%2C+Jeffrey+B%3BCoca%2C+Aitor%3BRoberge%2C+Marc+R%3BBenson%2C+Stacey+M&rft.aulast=Roberge&rft.aufirst=Raymond&rft.date=2010-08-01&rft.volume=54&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inhalation; Respirators; wear; Protective equipment; Occupational health ER - TY - JOUR T1 - Performance of High Flow Rate Samplers for Respirable Particle Collection AN - 759312822; 13650196 AB - The American Conference of Governmental Industrial hygienists (ACGIH) lowered the threshold limit value (TLV) for respirable crystalline silica (RCS) exposure from 0.05 to 0.025 mg m-3 in 2006. For a working environment with an airborne dust concentration near this lowered TLV, the sample collected with current standard respirable aerosol samplers might not provide enough RCS for quantitative analysis. Adopting high flow rate sampling devices for respirable dust containing silica may provide a sufficient amount of RCS to be above the limit of quantification even for samples collected for less than full shift. The performances of three high flow rate respirable samplers (CIP10-R, GK2.69, and FSP10) have been evaluated in this study. Eleven different sizes of monodisperse aerosols of ammonium fluorescein were generated with a vibrating orifice aerosol generator in a calm air chamber in order to determine the sampling efficiency of each sampler. Aluminum oxide particles generated by a fluidized bed aerosol generator were used to test (i) the uniformity of a modified calm air chamber, (ii) the effect of loading on the sampling efficiency, and (iii) the performance of dust collection compared to lower flow rate cyclones in common use in the USA (10-mm nylon and Higgins-Dewell cyclones). The coefficient of variation for eight simultaneous samples in the modified calm air chamber ranged from 1.9 to 6.1% for triplicate measures of three different aerosols. The 50% cutoff size (50dae) of the high flow rate samplers operated at the flow rates recommended by manufacturers were determined as 4.7, 4.1, and 4.8 km for CIP10-R, GK2.69, and FSP10, respectively. The mass concentration ratio of the high flow rate samplers to the low flow rate cyclones decreased with decreasing mass median aerodynamic diameter (MMAD) and high flow rate samplers collected more dust than low flow rate samplers by a range of 2-11 times based on gravimetric analysis. Dust loading inside the high flow rate samplers does not appear to affect the particle separation in either FSP10 or GK2.69. The high flow rate samplers overestimated compared to the International Standards Organization/Comite Europeen de Normalisation/ACGIH respirable convention [up to 40% at large MMAD (27.5 km)] and could provide overestimated exposure data with the current flow rates. However, both cyclones appeared to be able to provide relatively unbiased assessments of RCS when their flow rates were adjusted. JF - Annals of Occupational Hygiene AU - Lee, Taekhee AU - Kim, Seung Won AU - Chisholm, William P AU - Slaven, James AU - Harper, Martin AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 697 EP - 709 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 54 IS - 6 SN - 0003-4878, 0003-4878 KW - Health & Safety Science Abstracts KW - Aerosols KW - Conferences KW - Quantitative analysis KW - Particulates KW - cyclones KW - Flow rates KW - Dust KW - USA KW - silica KW - Fluidized beds KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759312822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Occupational+Hygiene&rft.atitle=Performance+of+High+Flow+Rate+Samplers+for+Respirable+Particle+Collection&rft.au=Lee%2C+Taekhee%3BKim%2C+Seung+Won%3BChisholm%2C+William+P%3BSlaven%2C+James%3BHarper%2C+Martin&rft.aulast=Lee&rft.aufirst=Taekhee&rft.date=2010-08-01&rft.volume=54&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Annals+of+Occupational+Hygiene&rft.issn=00034878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Aerosols; Conferences; silica; Fluidized beds; Quantitative analysis; Particulates; cyclones; Dust; Flow rates; USA ER - TY - JOUR T1 - Prenatal exposure to the major DDT metabolite 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and growth in boys from Mexico AN - 759309889; 13248086 AB - Recent data suggest that prenatal exposure to p,pa super(2)-DDE may reduce height and increase body mass index (BMI) in childhood, thus potentially raising the risk of adult health problems. The association between prenatal DDE exposure and growth was evaluated in 788 boys from Chiapas, an area of Mexico where DDT was recently used. The median DDE levels in maternal serum at birth (2002-2003) were 2.7I14g/g lipid. 2633 measurements of height (cm) and weight (kg) were obtained in 2004-2005. The median age of the children during follow-up was 18 months (quartiles 14 and 22 months). Height and body mass index (kg/m2) were age-standardized and expressed as standard deviation scores (SDS). Multivariate random-effect models for longitudinal data were fitted and predicted height and BMI SDS were estimated from the adjusted models. Overall, associations between prenatal DDE level and height or BMI SDS at any given age were not observed. For example, the predicted values showed that children with the highest exposure (DDE: >9.00I14g/g) compared to those least exposed (DDE: <3.01I14g/g) grew similarly and they had a BMI SDS similar to the referent group. The results do not support the prior findings of an association of DDE exposure with childhood height or BMI. JF - Environmental Research AU - Cupul-Uicab, Lea A AU - Hernandez-Avila, Mauricio AU - Terrazas-Medina, Efrain A AU - Pennell, Michael L AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3-05, 111 TW Alexander Dr, Research Triangle Park, NC 27709, USA PY - 2010 SP - 595 EP - 603 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 110 IS - 6 SN - 0013-9351, 0013-9351 KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts; Sustainability Science Abstracts KW - Body height KW - Body mass index KW - Child KW - Preschool KW - Growth and development KW - Infant KW - Longitudinal study KW - ppa super(2)-DDE KW - BMI KW - DDE KW - DDT KW - IQR KW - SD KW - SDS KW - Age KW - Prenatal experience KW - Lipids KW - Bone growth KW - Metabolites KW - Models KW - Insecticides KW - Nitrous oxide KW - body mass KW - Data processing KW - Children KW - Birth KW - prenatal experience KW - Mexico KW - Standard deviation KW - Sodium lauryl sulfate KW - Mexico, Chiapas KW - M3 1010:Issues in Sustainable Development KW - R2 23050:Environment KW - H 0500:General KW - X 24330:Agrochemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759309889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Prenatal+exposure+to+the+major+DDT+metabolite+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+growth+in+boys+from+Mexico&rft.au=Cupul-Uicab%2C+Lea+A%3BHernandez-Avila%2C+Mauricio%3BTerrazas-Medina%2C+Efrain+A%3BPennell%2C+Michael+L%3BLongnecker%2C+Matthew+P&rft.aulast=Cupul-Uicab&rft.aufirst=Lea&rft.date=2010-08-01&rft.volume=110&rft.issue=6&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2010.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-01-06 N1 - SubjectsTermNotLitGenreText - Age; Prenatal experience; Data processing; Body height; Lipids; DDE; Bone growth; Metabolites; Children; Models; Birth; Standard deviation; DDT; Sodium lauryl sulfate; Body mass index; prenatal experience; Insecticides; Nitrous oxide; body mass; Mexico; Mexico, Chiapas DO - http://dx.doi.org/10.1016/j.envres.2010.06.001 ER - TY - RPRT T1 - FOREWORD AN - 755511341 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755511341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF GOLDENSEAL ROOT POWDER (HYDRASTIS CANADENSIS) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) AN - 755509520; 21372858 AB - Goldenseal is a plant that has been used in herbal medicine for the treatment of gastrointestinal and urinary disorders and skin, mouth, and eye infections. Extracts of goldenseal root are dried to make teas or liquid extracts or combined with echinacea in tablets. We studied the effects of goldenseal root powder given to rats and mice in the feed to identify potential toxic or cancer-related hazards. We gave feed containing 3,000, 9,000, or 25,000 parts per million (ppm) of goldenseal root powder to groups of 50 male and female rats and mice for two years. Similar groups of animals were given feed with no chemical added and served as the control groups. At the end of the study tissues from more than 40 sites were examined for every animal. Survival of all exposed groups of animals was similar to their controls. The rates of cancer (hepatocellular adenoma) of the liver was markedly increased in male and female rats receiving 25,000 ppm goldenseal root powder, and male mice receiving goldenseal root powder had increased rates of liver hepatoblastomas and multiple hepatocellular adenomas. We conclude that goldenseal root powder caused cancer in the liver of male and female rats and male mice. There was no effect of goldenseal root powder on female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1 EP - 188 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Powders KW - Herbal medicine KW - Toxicology KW - Cancer KW - Herbs KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Mice KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Hydrastis -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GOLDENSEAL+ROOT+POWDER+%28HYDRASTIS+CANADENSIS%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Document feature - Illustrations; References; Graphs; Tables N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 755509435 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755509435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-08-01&rft.volume=&rft.issue=562&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Interferon-Lambda: A New Addition to an Old Family AN - 755141395; 13674138 AB - The discovery and initial description of the interferon-l. (IFN-l) family in early 2003 opened an exciting new chapter in the field of IFN research. There are 3 IFN-l genes that encode 3 distinct but highly related proteins denoted IFN-l1, -l2, and -l3. These proteins are also known as interleukin-29 (IL-29), IL-28A, and IL-28B, respectively. Collectively, these 3 cytokines comprise the type III subset of IFNs. They are distinct from both type I and type II IFNs for a number of reasons, including the fact that they signal through a heterodimeric receptor complex that is different from the receptors used by type I or type II IFNs. Although type I IFNs (IFN-a/b) and type III IFNs (IFN-l) signal via distinct receptor complexes, they activate the same intracellular signaling pathway and many of the same biological activities, including antiviral activity, in a wide variety of target cells. Consistent with their antiviral activity, expression of the IFN-l genes and their corresponding proteins is inducible by infection with many types of viruses. Therefore, expression of the type III IFNs (IFN-ls) and their primary biological activity are very similar to the type I IFNs. However, unlike IFN-a receptors which are broadly expressed on most cell types, including leukocytes, IFN-l receptors are largely restricted to cells of epithelial origin. The potential clinical importance of IFN-l as a novel antiviral therapeutic agent is already apparent. In addition, preclinical studies by several groups indicate that IFN-l may also be useful as a potential therapeutic agent for other clinical indications, including certain types of cancer. JF - Journal of Interferon & Cytokine Research AU - Donnelly, R P AU - Kotenko, S V AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Building 29A, Room 3B15, 29 Lincoln Drive, Bethesda, MD 20892, USA, raymond.donnelly@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 555 VL - 30 IS - 8 SN - 1079-9907, 1079-9907 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Interferon KW - Intracellular signalling KW - Leukocytes KW - alpha -Interferon KW - Antiviral activity KW - Infection KW - a-Interferon KW - Cancer KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755141395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interferon+%26+Cytokine+Research&rft.atitle=Interferon-Lambda%3A+A+New+Addition+to+an+Old+Family&rft.au=Donnelly%2C+R+P%3BKotenko%2C+S+V&rft.aulast=Donnelly&rft.aufirst=R&rft.date=2010-08-01&rft.volume=30&rft.issue=8&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interferon+%26+Cytokine+Research&rft.issn=10799907&rft_id=info:doi/10.1089%2Fjir.2010.0078 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Intracellular signalling; Interferon; alpha -Interferon; Leukocytes; Infection; Antiviral activity; Cancer; a-Interferon DO - http://dx.doi.org/10.1089/jir.2010.0078 ER - TY - JOUR T1 - Low Prevalence of Primary HIV Resistance in Western Massachusetts AN - 755136043; 13638135 AB - Most studies of primary antiretroviral (ARV) resistance have been conducted in large metropolitan areas with reported rates of 8% to 25%. We collected data on 99 HIV-1-infected antiretroviral-naive patients from several sites in Springfield, MA, who underwent genotypic resistance assay between 2004 and 2008. Only major resistance mutations per International AIDS Society-USA (IAS-USA) drug resistance mutations list were considered. The prevalence of resistance was 5% (5 of 99). Three patients had one nonnucleoside reverse transcriptase inhibitor (NNRTI) mutation: 103N, 103N, and 190A, 1 patient had a protease inhibitor (PI) mutation: 90M; and 1 patient had 3-class resistance with NNRTI: 181C, 190A, PI: 90M, and nucleoside analogue reverse transcriptase inhibitor (NRTI): 41L, 210W. Mean time from HIV diagnosis to resistance testing was shorter in patients with resistance versus those without: 9 (range 0.3-42 months) versus 27 (range 0.1-418 months), P = .11. There was a trend to lower mean CD4 count in those with resistance, 170 versus 318 cells/mm super(3), P = .06. No differences were noted in gender, age, HIV risk category, or HIV RNA level. The low prevalence of primary resistance may be explained by differences in demographic and risk factors or may reflect the time from infection to resistance testing. Our findings emphasize the importance of continued resistance surveillance. JF - Journal of the International Association of Physicians in AIDS Care (JIAPAC) AU - Iarikov, Dmitri E AU - Irizarry-Acosta, Melina AU - Martorell, Claudia AU - Hoffman, Robert P AU - Skiest, Daniel J AD - Division of Infectious Diseases, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA, Dmitri.Iarikov@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 227 EP - 231 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 9 IS - 4 SN - 1545-1097, 1545-1097 KW - Virology & AIDS Abstracts; Risk Abstracts KW - HIV KW - primary resistance KW - antiretroviral therapy KW - demography KW - Age KW - Acquired immune deficiency syndrome KW - Drug resistance KW - Infection KW - Demography KW - CD4 antigen KW - Antiviral agents KW - Risk factors KW - infection KW - RNA-directed DNA polymerase KW - metropolitan areas KW - proteinase inhibitors KW - USA, Massachusetts KW - non-nucleoside reverse transcriptase inhibitors KW - Data processing KW - Proteinase inhibitors KW - nucleoside analogs KW - RNA KW - Human immunodeficiency virus KW - Gender KW - USA, Illinois, Springfield KW - drug resistance KW - Mutation KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755136043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.atitle=Low+Prevalence+of+Primary+HIV+Resistance+in+Western+Massachusetts&rft.au=Iarikov%2C+Dmitri+E%3BIrizarry-Acosta%2C+Melina%3BMartorell%2C+Claudia%3BHoffman%2C+Robert+P%3BSkiest%2C+Daniel+J&rft.aulast=Iarikov&rft.aufirst=Dmitri&rft.date=2010-08-01&rft.volume=9&rft.issue=4&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Physicians+in+AIDS+Care+%28JIAPAC%29&rft.issn=15451097&rft_id=info:doi/10.1177%2F1545109710374998 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Number of references - 22 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Age; Data processing; non-nucleoside reverse transcriptase inhibitors; Drug resistance; Proteinase inhibitors; Infection; nucleoside analogs; Demography; CD4 antigen; Antiviral agents; RNA; Risk factors; RNA-directed DNA polymerase; Mutation; demography; proteinase inhibitors; Human immunodeficiency virus; Gender; infection; drug resistance; metropolitan areas; USA, Massachusetts; USA, Illinois, Springfield DO - http://dx.doi.org/10.1177/1545109710374998 ER - TY - JOUR T1 - Evaluation of the Integrated Database Network System (IDNS) SmartGene Software for Analysis of 16S rRNA Gene Sequences for Identification of Nocardia Species AN - 754558998; 13359675 AB - 16S rRNA gene sequences of 102 Nocardia isolates were analyzed using the Integrated Database Network System (IDNS) SmartGene centroid database. A total of 76% of the isolates were correctly identified. Discordant identifications were due to inadequate centroid length (3 species), inaccurate or insufficient entries in the public databases (5 species), and heterogeneous sequences among members of a species (1 species). JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Murray, Patrick R AU - Zelazny, Adrian M AD - Microbiology Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, pconville@mail.nih.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 2995 EP - 2998 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 48 IS - 8 SN - 0095-1137, 0095-1137 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Databases KW - Computer programs KW - software KW - Nocardia KW - rRNA 16S KW - J 02310:Genetics & Taxonomy KW - N 14815:Nucleotide Sequence KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754558998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+the+Integrated+Database+Network+System+%28IDNS%29+SmartGene+Software+for+Analysis+of+16S+rRNA+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BMurray%2C+Patrick+R%3BZelazny%2C+Adrian+M&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2010-08-01&rft.volume=48&rft.issue=8&rft.spage=2995&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00681-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; software; rRNA 16S; Nocardia DO - http://dx.doi.org/10.1128/JCM.00681-10 ER - TY - JOUR T1 - Improved Molecular Detection of Angiostrongylus cantonensis in Mollusks and Other Environmental Samples with a Species-Specific Internal Transcribed Spacer 1-Based TaqMan Assay AN - 754537297; 13245682 AB - Angiostrongylus cantonensis is the most common cause of human eosinophilic meningitis. Humans become infected by ingesting food items contaminated with third-stage larvae that develop in mollusks. We report the development of a real-time PCR assay for the species-specific identification of A. cantonensis in mollusk tissue. JF - Applied and Environmental Microbiology AU - Qvarnstrom, Yvonne AU - Aramburu da Silva, Ana Cristina AU - Teem, John L AU - Hollingsworth, Robert AU - Bishop, Henry AU - Graeff-Teixeira, Carlos AU - da Silva, Alexandre J AD - Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia, abs8@cdc.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 5287 EP - 5289 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Food contamination KW - Spacer KW - Angiostrongylus cantonensis KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754537297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Improved+Molecular+Detection+of+Angiostrongylus+cantonensis+in+Mollusks+and+Other+Environmental+Samples+with+a+Species-Specific+Internal+Transcribed+Spacer+1-Based+TaqMan+Assay&rft.au=Qvarnstrom%2C+Yvonne%3BAramburu+da+Silva%2C+Ana+Cristina%3BTeem%2C+John+L%3BHollingsworth%2C+Robert%3BBishop%2C+Henry%3BGraeff-Teixeira%2C+Carlos%3Bda+Silva%2C+Alexandre+J&rft.aulast=Qvarnstrom&rft.aufirst=Yvonne&rft.date=2010-08-01&rft.volume=76&rft.issue=15&rft.spage=5287&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00546-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Spacer; Angiostrongylus cantonensis DO - http://dx.doi.org/10.1128/AEM.00546-10 ER - TY - JOUR T1 - Parvovirus B19 infection transmitted by transfusion of red blood cells confirmed by molecular analysis of linked donor and recipient samples AN - 754536782; 13247453 AB - Extremely high viremic levels of parvovirus B19 (B19V) can be found in acutely infected, but asymptomatic donors. However, reports of transmission by single-donor blood components are rare. In this prospective study, paired donor-recipient samples were used to investigate the transfusion risk. JF - Transfusion AU - Yu, Mei-ying W AU - Alter, Harvey J AU - Virata-Theimer, Maria Luisa A AU - Geng, Yansheng AU - Ma, Li AU - Schechterly, Cathy A AU - Colvin, Camilla A AU - Luban, Naomi LC AD - From the Division of Hematology, Center for Biologics Evaluation and Research (CBER), FDA, and the Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, NIH, Bethesda, Maryland; and the Division of Laboratory Medicine, Children's National Medical Center, Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC. Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1712 EP - 1721 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 8 SN - 0041-1132, 0041-1132 KW - Risk Abstracts KW - Parvovirus B19 KW - infection KW - transfusion KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Parvovirus+B19+infection+transmitted+by+transfusion+of+red+blood+cells+confirmed+by+molecular+analysis+of+linked+donor+and+recipient+samples&rft.au=Yu%2C+Mei-ying+W%3BAlter%2C+Harvey+J%3BVirata-Theimer%2C+Maria+Luisa+A%3BGeng%2C+Yansheng%3BMa%2C+Li%3BSchechterly%2C+Cathy+A%3BColvin%2C+Camilla+A%3BLuban%2C+Naomi+LC&rft.aulast=Yu&rft.aufirst=Mei-ying&rft.date=2010-08-01&rft.volume=50&rft.issue=8&rft.spage=1712&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2010.02591.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - infection; transfusion; Parvovirus B19 DO - http://dx.doi.org/10.1111/j.1537-2995.2010.02591.x ER - TY - JOUR T1 - Consistency of predictive signature genes and classifiers generated using different microarray platforms AN - 754536602; 13243590 AB - Microarray-based classifiers and associated signature genes generated from various platforms are abundantly reported in the literature; however, the utility of the classifiers and signature genes in cross-platform prediction applications remains largely uncertain. As part of the MicroArray Quality Control Phase II (MAQC-II) project, we show in this study 80-90% cross-platform prediction consistency using a large toxicogenomics data set by illustrating that: (1) the signature genes of a classifier generated from one platform can be directly applied to another platform to develop a predictive classifier; (2) a classifier developed using data generated from one platform can accurately predict samples that were profiled using a different platform. The results suggest the potential utility of using published signature genes in cross-platform applications and the possible adoption of the published classifiers for a variety of applications. The study reveals an opportunity for possible translation of biomarkers identified using microarrays to clinically validated non-array gene expression assays. JF - Pharmacogenomics Journal AU - Fan, X AU - Lobenhofer, E K AU - Chen, M AU - Shi, W AU - Huang, J AU - Luo, J AU - Zhang, J AU - Walker, S J AU - Chu, T-M AU - Li, L AU - Wolfinger, R AU - Bao, W AU - Paules, R S AU - Bushel, P R AU - Li, J AU - Shi, T AU - Nikolskaya, T AU - Nikolsky, Y AU - Hong, H AU - Deng, Y AU - Cheng, Y AU - Fang, H AU - Shi, L AU - Tong, W AD - Center for Toxicoinformatics, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 247 EP - 257 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 10 IS - 4 SN - 1470-269X, 1470-269X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Translation KW - Data processing KW - Quality control KW - Adoption KW - DNA microarrays KW - biomarkers KW - G 07880:Human Genetics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754536602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics+Journal&rft.atitle=Consistency+of+predictive+signature+genes+and+classifiers+generated+using+different+microarray+platforms&rft.au=Fan%2C+X%3BLobenhofer%2C+E+K%3BChen%2C+M%3BShi%2C+W%3BHuang%2C+J%3BLuo%2C+J%3BZhang%2C+J%3BWalker%2C+S+J%3BChu%2C+T-M%3BLi%2C+L%3BWolfinger%2C+R%3BBao%2C+W%3BPaules%2C+R+S%3BBushel%2C+P+R%3BLi%2C+J%3BShi%2C+T%3BNikolskaya%2C+T%3BNikolsky%2C+Y%3BHong%2C+H%3BDeng%2C+Y%3BCheng%2C+Y%3BFang%2C+H%3BShi%2C+L%3BTong%2C+W&rft.aulast=Fan&rft.aufirst=X&rft.date=2010-08-01&rft.volume=10&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics+Journal&rft.issn=1470269X&rft_id=info:doi/10.1038%2Ftpj.2010.34 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Translation; Data processing; Quality control; Adoption; biomarkers; DNA microarrays DO - http://dx.doi.org/10.1038/tpj.2010.34 ER - TY - JOUR T1 - Characterization of a gne::IS629 O Rough:H7 Escherichia coli Strain from a Hemorrhagic Colitis Patient AN - 754535416; 13245689 AB - Shiga-toxigenic Escherichia coli strains that are O rough:H7 due to gne::IS629 were thought to be rare and to have unknown pathogenic potential. Recently, an O rough:H7 strain caused by gne::IS629 was isolated from a hemorrhagic colitis patient, suggesting that these strains are pathogenic and may not be as rare as anticipated. JF - Applied and Environmental Microbiology AU - Rump, Lydia V AU - Beutin, Lothar AU - Fischer, Markus AU - Feng, Peter CH AD - Division of Microbiology, Food and Drug Administration, College Park, Maryland 20740, peter.feng@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 5290 EP - 5291 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - Colitis KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754535416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Characterization+of+a+gne%3A%3AIS629+O+Rough%3AH7+Escherichia+coli+Strain+from+a+Hemorrhagic+Colitis+Patient&rft.au=Rump%2C+Lydia+V%3BBeutin%2C+Lothar%3BFischer%2C+Markus%3BFeng%2C+Peter+CH&rft.aulast=Rump&rft.aufirst=Lydia&rft.date=2010-08-01&rft.volume=76&rft.issue=15&rft.spage=5290&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00740-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Colitis; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.00740-10 ER - TY - JOUR T1 - Reactive aggression and functional, not neural, specificity AN - 754135051; 201019961 AB - This article is an author response to Harenski and Kiehl's (2010) commentary on Blair (2010). Adapted from the source document. JF - British Journal of Psychology AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 407 EP - 410 PB - The British Psychological Society, Leicester UK VL - 101 IS - 3 SN - 0007-1269, 0007-1269 KW - Aggression KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754135051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Psychology&rft.atitle=Reactive+aggression+and+functional%2C+not+neural%2C+specificity&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2010-08-01&rft.volume=101&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Psychology&rft.issn=00071269&rft_id=info:doi/10.1348%2F000712610X512122 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - BJSGAE N1 - SubjectsTermNotLitGenreText - Aggression DO - http://dx.doi.org/10.1348/000712610X512122 ER - TY - JOUR T1 - What we know and don't know about the bioeffects of nanoparticles: developing experimental approaches for safety assessment AN - 753675904; 13223444 AB - The Center for Devices and Radiological Health (CDRH) of the US Food and Drug Administration (FDA) regulates nano-based medical products and therefore is required to address the safety and biological effects of nano-scale materials used in these products. Both in vitro and in vivo toxicological research studies are being conducted at the FDA to help determine the risks versus benefits of these new products. This article will briefly summarize some of the initial research findings from FDA-CDRH studies using TiO sub(2), polystyrene, and silicon nanoparticles. JF - Biomedical Microdevices AU - Stratmeyer, Mel E AU - Goering, Peter L AU - Hitchins, Victoria M AU - Umbreit, Thomas H AD - Center for Devices and Radiological Health, Food and Drug Administration, WO64-4078, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 569 EP - 573 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 12 IS - 4 SN - 1387-2176, 1387-2176 KW - Biotechnology and Bioengineering Abstracts KW - Silicon KW - Medical equipment KW - polystyrene KW - nanoparticles KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753675904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Microdevices&rft.atitle=What+we+know+and+don%27t+know+about+the+bioeffects+of+nanoparticles%3A+developing+experimental+approaches+for+safety+assessment&rft.au=Stratmeyer%2C+Mel+E%3BGoering%2C+Peter+L%3BHitchins%2C+Victoria+M%3BUmbreit%2C+Thomas+H&rft.aulast=Stratmeyer&rft.aufirst=Mel&rft.date=2010-08-01&rft.volume=12&rft.issue=4&rft.spage=569&rft.isbn=&rft.btitle=&rft.title=Biomedical+Microdevices&rft.issn=13872176&rft_id=info:doi/10.1007%2Fs10544-008-9261-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Silicon; Medical equipment; polystyrene; nanoparticles DO - http://dx.doi.org/10.1007/s10544-008-9261-9 ER - TY - JOUR T1 - Neurotoxicity of ecstasy (MDMA): an overview. AN - 748930383; 20420572 AB - "Ecstasy" (MDMA) is a powerful hallucinogenic drug which has raised concern worldwide because of its high abuse liability. A plethora of studies have demonstrated that MDMA has the potential to induce neurotoxicity both in human and laboratory animals. Although research on MDMA has been carried out by many different laboratories, the mechanism underlying MDMA induced toxicity has not been fully elucidated. MDMA has the ability to reduce serotonin levels in terminals of axons in the cortex of rats and mice. Recently we have shown that it also has the potential to produce degenerate neurons in discrete areas of the brain such as insular and parietal cortex, thalamus, tenia tecta and bed nucleus of stria terminalis (BST). Acute effects of MDMA can result in a constellation of changes including arrthymias, hypertension, hyperthermia, serotonin (5-HT) syndrome, liver problems, seizures and also long lasting neurocognitive impairments including mood disturbances. In human MDMA abusers, there is evidence for reduction of serotonergic biochemical markers. Several factors may contribute to the MDMA-induced neurotoxicity, especially hyperthermia. Other factors potentially influencing MDMA toxicity include monoamine oxidase metabolism of dopamine and serotonin, nitric oxide generation, glutamate excitotoxicity, serotonin 2A receptor agonism and the formation of MDMA neurotoxic metabolites. In this review we will cover the following topics: pharmacological mechanisms, metabolic pathways and acute effects in laboratory animals, as well as in humans, with special attention on the mechanism and pathology of MDMA induced neurotoxicity. JF - Current pharmaceutical biotechnology AU - Sarkar, Sumit AU - Schmued, Larry AD - Department of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 460 EP - 469 VL - 11 IS - 5 KW - Hallucinogens KW - 0 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Mice KW - Hallucinogens -- toxicity KW - Brain -- physiopathology KW - Brain -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Nervous System Diseases -- physiopathology KW - Models, Neurological KW - Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748930383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+biotechnology&rft.atitle=Neurotoxicity+of+ecstasy+%28MDMA%29%3A+an+overview.&rft.au=Sarkar%2C+Sumit%3BSchmued%2C+Larry&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2010-08-01&rft.volume=11&rft.issue=5&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+biotechnology&rft.issn=1873-4316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-15 N1 - Date created - 2010-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. AN - 748927244; 20368714 AB - The discordance in results of independent genome-wide association studies (GWAS) indicates the potential for Type I and Type II errors. We assessed the repeatibility of current Affymetrix technologies that support GWAS. Reasonable reproducibility was observed for both raw intensity and the genotypes/copy number variants. We also assessed consistencies between different SNP arrays and between genotype calling algorithms. We observed that the inconsistency in genotypes was generally small at the specimen level. To further examine whether the differences from genotyping and genotype calling are possible sources of variation in GWAS results, an association analysis was applied to compare the associated SNPs. We observed that the inconsistency in genotypes not only propagated to the association analysis, but was amplified in the associated SNPs. Our studies show that inconsistencies between SNP arrays and between genotype calling algorithms are potential sources for the lack of reproducibility in GWAS results. JF - The pharmacogenomics journal AU - Hong, H AU - Shi, L AU - Su, Z AU - Ge, W AU - Jones, W D AU - Czika, W AU - Miclaus, K AU - Lambert, C G AU - Vega, S C AU - Zhang, J AU - Ning, B AU - Liu, J AU - Green, B AU - Xu, L AU - Fang, H AU - Perkins, R AU - Lin, S M AU - Jafari, N AU - Park, K AU - Ahn, T AU - Chierici, M AU - Furlanello, C AU - Zhang, L AU - Wolfinger, R D AU - Goodsaid, F AU - Tong, W AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. huixiao.hong@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 364 EP - 374 VL - 10 IS - 4 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Reproducibility of Results KW - Humans KW - DNA -- genetics KW - Oligonucleotide Array Sequence Analysis -- methods KW - Algorithms KW - Data Interpretation, Statistical KW - Gene Dosage KW - Genotype KW - Haplotypes -- genetics KW - Genome-Wide Association Study -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748927244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=Assessing+sources+of+inconsistencies+in+genotypes+and+their+effects+on+genome-wide+association+studies+with+HapMap+samples.&rft.au=Hong%2C+H%3BShi%2C+L%3BSu%2C+Z%3BGe%2C+W%3BJones%2C+W+D%3BCzika%2C+W%3BMiclaus%2C+K%3BLambert%2C+C+G%3BVega%2C+S+C%3BZhang%2C+J%3BNing%2C+B%3BLiu%2C+J%3BGreen%2C+B%3BXu%2C+L%3BFang%2C+H%3BPerkins%2C+R%3BLin%2C+S+M%3BJafari%2C+N%3BPark%2C+K%3BAhn%2C+T%3BChierici%2C+M%3BFurlanello%2C+C%3BZhang%2C+L%3BWolfinger%2C+R+D%3BGoodsaid%2C+F%3BTong%2C+W&rft.aulast=Hong&rft.aufirst=H&rft.date=2010-08-01&rft.volume=10&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2010.24 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-11-04 N1 - Date created - 2010-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2005 Apr 15;308(5720):385-9 [15761122] J Natl Cancer Inst. 2004 Mar 17;96(6):434-42 [15026468] Am J Hum Genet. 2006 Feb;78(2):350-6 [16400614] Hum Hered. 2006;61(1):55-64 [16612103] Nat Genet. 2006 Jun;38(6):617-9 [16699517] Nat Genet. 2006 Aug;38(8):904-9 [16862161] Science. 2006 Nov 10;314(5801):989-92 [17053108] Science. 2006 Dec 1;314(5804):1461-3 [17068223] Am J Hum Genet. 2007 Feb;80(2):273-90 [17236132] Nat Genet. 2007 Feb;39(2):207-11 [17200669] Nature. 2007 Feb 22;445(7130):881-5 [17293876] Nat Genet. 2007 May;39(5):645-9 [17401363] Nat Genet. 2007 May;39(5):631-7 [17401366] Nat Genet. 2007 May;39(5):596-604 [17435756] Hum Mol Genet. 2007 Apr 15;16(8):865-73 [17317784] Science. 2007 May 11;316(5826):889-94 [17434869] Nat Genet. 2007 Jun;39(6):770-5 [17460697] Science. 2007 Jun 1;316(5829):1331-6 [17463246] Science. 2007 Jun 1;316(5829):1341-5 [17463248] Science. 2007 Jun 1;316(5829):1336-41 [17463249] Nature. 2007 Jun 7;447(7145):661-78 [17554300] Nat Genet. 2007 Jul;39(7):870-4 [17529973] Nat Genet. 2007 Jul;39(7):857-64 [17554260] Nat Genet. 2007 Jul;39(7):827-9 [17558408] Nature. 2007 Jun 28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):989-94 [17618283] Nat Genet. 2007 Aug;39(8):984-8 [17618284] Nat Genet. 2007 Aug;39(8):995-9 [17632509] Nat Genet. 2007 Aug;39(8):1000-6 [17637780] Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14747-52 [17804789] Nature. 2007 Oct 18;449(7164):851-61 [17943122] Am J Hum Genet. 2008 Jan;82(1):160-4 [18179894] Am J Hum Genet. 2008 Feb;82(2):411-23 [18252221] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5 [18245381] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4340-5 [18326623] Nat Rev Genet. 2008 May;9(5):356-69 [18398418] Methods Mol Med. 2008;141:23-35 [18453082] BMC Bioinformatics. 2008;9 Suppl 9:S17 [18793462] Trends Genet. 2001 Sep;17(9):502-10 [11525833] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):505-12 [12050090] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Lancet. 2003 Feb 15;361(9357):598-604 [12598158] Bioinformatics. 2005 May 1;21(9):1958-63 [15657097] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/tpj.2010.24 ER - TY - JOUR T1 - DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential? AN - 734006097; 19783790 AB - DNA double-strand breaks (DSBs) can result in cell death or genetic alterations when cells are subjected to radiation, exposure to toxins, or other environmental stresses. A complex DNA-damage-response pathway is activated to repair the damage, and the inability to repair these breaks can lead to carcinogenesis. One of the earliest responses to DNA DSBs is the phosphorylation of a histone, H2AX, at serine 139 (gamma-H2AX), which can be detected by a fluorescent antibody. A study was undertaken to compare the induction of DNA DSBs in normal (small airway epithelial) cells and cancer cells (A549) after exposure to asbestos (crocidolite), a proven carcinogen, silica, a suspected carcinogen, and titanium dioxide (TiO(2)), an inert particle recently reported to be carcinogenic in animals. The results indicate that crocidolite induced greater DNA DSBs than silica and TiO(2), regardless of cell type. DNA DSBs caused by crocidolite were higher in normal cells than in cancer cells. Silica and TiO(2) induced higher DNA DSBs in cancer cells than in normal cells. The production of reactive oxygen species was found to be highest in cells exposed to crocidolite, followed, in potency, by silica and TiO(2). The generation of reactive oxygen species was higher in normal cells than in cancer cells. Cell viability assay indicated that crocidolite caused the greatest cytotoxicity in both cell types. Apoptosis, measured by caspase 3/7 and poly (ADP-Ribose) polymerase activation, was highest in crocidolite-exposed cells, followed by TiO(2) and silica. The results of this study indicate that crocidolite has a greater carcinogenic potential than silica and TiO(2), judged by its ability to cause sustained genomic instability in normal lung cells. JF - American journal of respiratory cell and molecular biology AU - Msiska, Zola AU - Pacurari, Maricica AU - Mishra, Anurag AU - Leonard, Stephen S AU - Castranova, Vince AU - Vallyathan, Val AD - Pathology and Physiology Research Branch, Health Effects Laboratory Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 210 EP - 219 VL - 43 IS - 2 KW - Biomarkers, Tumor KW - 0 KW - Carcinogens KW - Reactive Oxygen Species KW - Asbestos KW - 1332-21-4 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - DNA KW - 9007-49-2 KW - Titanium KW - D1JT611TNE KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Carcinogens -- metabolism KW - Enzyme Activation KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Cell Line, Tumor KW - Caspases -- metabolism KW - Cell Survival KW - Silicon Dioxide -- pharmacology KW - Biomarkers, Tumor -- metabolism KW - Titanium -- pharmacology KW - Neoplasms -- chemically induced KW - Asbestos -- pharmacology KW - DNA Breaks, Double-Stranded KW - Neoplasms -- metabolism KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734006097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=DNA+double-strand+breaks+by+asbestos%2C+silica%2C+and+titanium+dioxide%3A+possible+biomarker+of+carcinogenic+potential%3F&rft.au=Msiska%2C+Zola%3BPacurari%2C+Maricica%3BMishra%2C+Anurag%3BLeonard%2C+Stephen+S%3BCastranova%2C+Vince%3BVallyathan%2C+Val&rft.aulast=Msiska&rft.aufirst=Zola&rft.date=2010-08-01&rft.volume=43&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=1535-4989&rft_id=info:doi/10.1165%2Frcmb.2009-0062OC LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1165/rcmb.2009-0062OC ER - TY - JOUR T1 - Application of nanotechnology in cosmetics. AN - 733630915; 20407919 JF - Pharmaceutical research AU - Mu, Li AU - Sprando, Robert L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. Li.Mu@fda.hhs.gov Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 1746 EP - 1749 VL - 27 IS - 8 KW - Cosmetics KW - 0 KW - Dermatologic Agents KW - Index Medicus KW - Risk Factors KW - Humans KW - Dermatologic Agents -- administration & dosage KW - Cosmetics -- chemistry KW - Nanotechnology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733630915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+research&rft.atitle=Application+of+nanotechnology+in+cosmetics.&rft.au=Mu%2C+Li%3BSprando%2C+Robert+L&rft.aulast=Mu&rft.aufirst=Li&rft.date=2010-08-01&rft.volume=27&rft.issue=8&rft.spage=1746&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+research&rft.issn=1573-904X&rft_id=info:doi/10.1007%2Fs11095-010-0139-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-13 N1 - Date created - 2010-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11095-010-0139-1 ER - TY - JOUR T1 - Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure. AN - 733348003; 20340164 AB - Amphetamine (AMPH) is used to treat attention deficit and hyperactivity disorders, but it can produce neurotoxicity and adverse vascular effects at high doses. The endoplasmic reticulum (ER) stress response (ERSR) entails the unfolded protein response, which helps to avoid or minimize ER dysfunction. ERSR is often associated with toxicities resulting from the accumulation of unfolded or misfolded proteins and has been associated with methamphetamine toxicity in the striatum. The present study evaluates the effect of AMPH on several ERSR elements in meninges and associated vasculature (MAV), parietal cortex, and striatum. Adult, male Sprague-Dawley rats were exposed to saline, environmentally induced hyperthermia (EIH) or four consecutive doses of AMPH that produce hyperthermia. Expression changes (mRNA and protein levels) of key ERSR-related genes in MAV, striatum, and parietal cortex at 3 h or 1 day postdosing were monitored. AMPH increased the expression of some ERSR-related genes in all tissues. Atf4 (activating transcription factor 4, an indicator of Perk pathway activation), Hspa5/Grp78 (Glucose regulated protein 78, master regulator of ERSR), Pdia4 (protein disulfide isomerase, protein-folding enzyme), and Nfkb1 (nuclear factor of kappa b, ERSR sensor) mRNA increased significantly in MAV and parietal cortex 3 h after AMPH. In striatum, Atf4 and Hspa5/Grp78 mRNA significantly increased 3 h after AMPH, but Pdia4 and Nfkb11 did not. Thus, AMPH caused a robust activation of the Perk pathway in all tissues, but significant Ire1 pathway activation occurred only after AMPH treatment in the parietal cortex and striatum. Ddit3/Chop, a downstream effector of the ERSR pathway related to the neurotoxicity, was only increased in striatum and parietal cortex. Conversely, Pdia4, an enzyme protective in the ERSR, was only increased in MAV. The overall ERSR manifestation varied significantly between MAV, striatum, and parietal cortex after a neurotoxic exposure to AMPH. JF - Synapse (New York, N.Y.) AU - Thomas, Monzy AU - George, Nysia I AU - Saini, Upasana T AU - Patterson, Tucker A AU - Hanig, Joseph P AU - Bowyer, John F AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA. Y1 - 2010/08// PY - 2010 DA - August 2010 SP - 579 EP - 593 VL - 64 IS - 8 KW - Neurotoxins KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Time Factors KW - Neurotoxins -- toxicity KW - Male KW - Stress, Physiological -- physiology KW - Amphetamine -- toxicity KW - Cerebrovascular Circulation -- drug effects KW - Cerebrovascular Circulation -- physiology KW - Meninges -- blood supply KW - Endoplasmic Reticulum -- pathology KW - Meninges -- drug effects KW - Stress, Physiological -- drug effects KW - Corpus Striatum -- blood supply KW - Parietal Lobe -- blood supply KW - Meninges -- physiopathology KW - Corpus Striatum -- physiopathology KW - Endoplasmic Reticulum -- physiology KW - Corpus Striatum -- drug effects KW - Parietal Lobe -- physiopathology KW - Parietal Lobe -- drug effects KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733348003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Endoplasmic+reticulum+stress+responses+differ+in+meninges+and+associated+vasculature%2C+striatum%2C+and+parietal+cortex+after+a+neurotoxic+amphetamine+exposure.&rft.au=Thomas%2C+Monzy%3BGeorge%2C+Nysia+I%3BSaini%2C+Upasana+T%3BPatterson%2C+Tucker+A%3BHanig%2C+Joseph+P%3BBowyer%2C+John+F&rft.aulast=Thomas&rft.aufirst=Monzy&rft.date=2010-08-01&rft.volume=64&rft.issue=8&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=1098-2396&rft_id=info:doi/10.1002%2Fsyn.20763 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-01-26 N1 - Date created - 2010-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/syn.20763 ER - TY - JOUR T1 - Occupational exposure limits for nanomaterials: state of the art AN - 1434016870; 18523680 AB - Assessing the need for and effectiveness of controlling airborne exposures to engineered nanomaterials in the workplace is difficult in the absence of occupational exposure limits (OELs). At present, there are practically no OELs specific to nanomaterials that have been adopted or promulgated by authoritative standards and guidance organizations. The vast heterogeneity of nanomaterials limits the number of specific OELs that are likely to be developed in the near future, but OELs could be developed more expeditiously for nanomaterials by applying dose-response data generated from animal studies for specific nanoparticles across categories of nanomaterials with similar properties and modes of action. This article reviews the history, context, and approaches for developing OELs for particles in general and nanoparticles in particular. Examples of approaches for developing OELs for titanium dioxide and carbon nanotubes are presented and interim OELs from various organizations for some nanomaterials are discussed. When adequate dose-response data are available in animals or humans, quantitative risk assessment methods can provide estimates of adverse health risk of nanomaterials in workers and, in conjunction with workplace exposure and control data, provide a basis for determining appropriate exposure limits. In the absence of adequate quantitative data, qualitative approaches to hazard assessment, exposure control, and safe work practices are prudent measures to reduce hazards in workers. JF - Journal of Nanoparticle Research AU - Schulte, P A AU - Murashov, V AU - Zumwalde, R AU - Kuempel, ED AU - Geraci, CL AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH, 45226, USA, PSchulte@cdc.gov Y1 - 2010/08// PY - 2010 DA - Aug 2010 SP - 1971 EP - 1987 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 12 IS - 6 SN - 1388-0764, 1388-0764 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Health risks KW - Historical account KW - Titanium dioxide KW - Dose-response effects KW - Reviews KW - Particulates KW - Occupational exposure KW - Nanotechnology KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1434016870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nanoparticle+Research&rft.atitle=Occupational+exposure+limits+for+nanomaterials%3A+state+of+the+art&rft.au=Schulte%2C+P+A%3BMurashov%2C+V%3BZumwalde%2C+R%3BKuempel%2C+ED%3BGeraci%2C+CL&rft.aulast=Schulte&rft.aufirst=P&rft.date=2010-08-01&rft.volume=12&rft.issue=6&rft.spage=1971&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nanoparticle+Research&rft.issn=13880764&rft_id=info:doi/10.1007%2Fs11051-010-0008-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-09-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Risk assessment; Historical account; Health risks; Titanium dioxide; Reviews; Dose-response effects; Particulates; Occupational exposure; Nanotechnology DO - http://dx.doi.org/10.1007/s11051-010-0008-1 ER - TY - JOUR T1 - Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine. AN - 733985876; 20510887 AB - The goal of this study was twofold: (a) to search for possible interactive effects between two common drugs of abuse, ethanol and methamphetamine. b) To inquire whether any effects of ethanol could be replicated using an equivalent amount of ethanol in the form of red wine. Adult male C57/6N mice received 2% ethanol for 8 weeks in drinking water or red wine diluted to yield the same ethanol content. On the 9th week animals received multiple injections of methamphetamine (4 x 10 mg/kg, ip, every 2 h). They were then sacrificed 72 h after treatment. Methamphetamine produced a significant depletion of dopamine and DOPAC in the striatum. Treatment with both ethanol and methamphetamine led to a reduction of striatal dopamine and DOPAC that were both non-significantly greater than that observed with methamphetamine alone. Alcohol alone produced no changes in the striatal content of dopamine or its metabolite, DOPAC. These data suggest that low doses of alcohol potentiate methamphetamine-induced neurotoxicity in mice and that this combination may be especially detrimental to the brain. However, an equivalent dose of ethanol in the form of red wine actually partially protected against methamphetamine-induced depletion of dopamine and DOPAC in red wine treated mice. This implies the presence of other agents in red wine, which may mitigate the toxicity of methamphetamine. Copyright 2010 Elsevier B.V. All rights reserved. JF - Brain research AU - Ali, Syed F AU - Bondy, S C AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079-9502, USA. Y1 - 2010/07/30/ PY - 2010 DA - 2010 Jul 30 SP - 247 EP - 250 VL - 1346 KW - Central Nervous System Depressants KW - 0 KW - Central Nervous System Stimulants KW - Neuroprotective Agents KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Ethanol KW - 3K9958V90M KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Brain Chemistry -- drug effects KW - Mice, Inbred C57BL KW - Dopamine -- metabolism KW - Mice KW - Male KW - Chromatography, High Pressure Liquid KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Central Nervous System Stimulants -- toxicity KW - Neurotoxicity Syndromes -- prevention & control KW - Central Nervous System Stimulants -- antagonists & inhibitors KW - Methamphetamine -- antagonists & inhibitors KW - Wine KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733985876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Red+wine+but+not+ethanol+at+low+doses+can+protect+against+the+toxicity+of+methamphetamine.&rft.au=Ali%2C+Syed+F%3BBondy%2C+S+C&rft.aulast=Ali&rft.aufirst=Syed&rft.date=2010-07-30&rft.volume=1346&rft.issue=&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2010.05.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-19 N1 - Date created - 2010-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.brainres.2010.05.058 ER - TY - CPAPER T1 - Self-perception of Weight and Health and Dietary Quality T2 - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AN - 1312931792; 6017900 JF - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AU - Lin, Chung-Tung AU - Lee, Jonq-Ying Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Diets UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312931792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.atitle=Self-perception+of+Weight+and+Health+and+Dietary+Quality&rft.au=Lin%2C+Chung-Tung%3BLee%2C+Jonq-Ying&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaea.org/2010am/Posters.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Discovery of a Selective Chk1 Inhibitor for the Treatment of Cancer T2 - 2010 Gordon Research Conference on Natural Products AN - 1312916033; 6010148 JF - 2010 Gordon Research Conference on Natural Products AU - Barda, David Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Cancer KW - CHK1 protein KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312916033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+Natural+Products&rft.atitle=Discovery+of+a+Selective+Chk1+Inhibitor+for+the+Treatment+of+Cancer&rft.au=Barda%2C+David&rft.aulast=Barda&rft.aufirst=David&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+Natural+Products&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=natproduct LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Influences of Labeling Policy and Media Coverage on the Demand for Butter and Margarine T2 - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AN - 1312885820; 6017393 JF - Joint Annual Meeting of the Agricultural and Applied Economics Association, Canadian Agricultural Economics Society and Western Agricultural Economics Association (AAEA-CAES-WAEA 2010) AU - Lin, Chung-Tung AU - Lee, Jonq-Ying Y1 - 2010/07/25/ PY - 2010 DA - 2010 Jul 25 KW - Margarine KW - Butter KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312885820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.atitle=Influences+of+Labeling+Policy+and+Media+Coverage+on+the+Demand+for+Butter+and+Margarine&rft.au=Lin%2C+Chung-Tung%3BLee%2C+Jonq-Ying&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2010-07-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Joint+Annual+Meeting+of+the+Agricultural+and+Applied+Economics+Association%2C+Canadian+Agricultural+Economics+Society+and+Western+Agricultural+Economics+Association+%28AAEA-CAES-WAEA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaea.org/2010am/Concurrent_Sessions.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Cooperative interactions at the SLP-76 complex are critical for actin polymerization AN - 645277485; 20562827 AB - T-cell antigen receptor (TCR) engagement induces formation of multi-protein signalling complexes essential for regulating T-cell functions. Generation of a complex of SLP-76, Nck and VAV1 is crucial for regulation of the actin machinery. We define the composition, stoichiometry and specificity of interactions in the SLP-76, Nck and VAV1 complex. Our data reveal that this complex can contain one SLP-76 molecule, two Nck and two VAV1 molecules. A direct interaction between Nck and VAV1 is mediated by binding between the C-terminal SH3 domain of Nck and the VAV1 N-terminal SH3 domain. Disruption of the VAV1:Nck interaction deleteriously affected actin polymerization. These novel findings shed new light on the mechanism of actin polymerization after T-cell activation. [PUBLICATION ABSTRACT] JF - EMBO Journal AU - Barda-saad, Mira AU - Shirasu, Naoto AU - Pauker, Maor H AU - Hassan, Nirit AU - Perl, Orly AU - Balbo, Andrea AU - Yamaguchi, Hiroshi AU - Houtman, Jon C D AU - Appella, Ettore AU - Schuck, Peter AU - Samelson, Lawrence E Y1 - 2010/07/21/ PY - 2010 DA - 2010 Jul 21 SP - 2315 EP - 28 CY - Heidelberg PB - Blackwell Publishing Ltd. VL - 29 IS - 14 SN - 02614189 KW - Biology--Cytology And Histology KW - Actins KW - Adaptor Proteins, Signal Transducing KW - Nck protein KW - Oncogene Proteins KW - Phosphoproteins KW - Proto-Oncogene Proteins c-vav KW - Receptors, Antigen, T-Cell KW - Recombinant Fusion Proteins KW - SLP-76 signal Transducing adaptor proteins KW - VAV1 protein, human KW - Antigens KW - Lymphocytes KW - Signal transduction KW - Molecular biology KW - Immune system KW - Cellular biology KW - Gene expression KW - Animals KW - T-Lymphocytes -- cytology KW - Phosphoproteins -- genetics KW - Humans KW - Jurkat Cells KW - Receptors, Antigen, T-Cell -- metabolism KW - Oncogene Proteins -- genetics KW - Protein Binding KW - src Homology Domains KW - Lymphocyte Activation KW - Recombinant Fusion Proteins -- metabolism KW - T-Lymphocytes -- metabolism KW - Proto-Oncogene Proteins c-vav -- genetics KW - Recombinant Fusion Proteins -- genetics KW - Adaptor Proteins, Signal Transducing -- genetics KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Signal Transduction -- physiology KW - Proto-Oncogene Proteins c-vav -- metabolism KW - Actins -- metabolism KW - Oncogene Proteins -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/645277485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Cooperative+interactions+at+the+SLP-76+complex+are+critical+for+actin+polymerization&rft.au=Barda-saad%2C+Mira%3BShirasu%2C+Naoto%3BPauker%2C+Maor+H%3BHassan%2C+Nirit%3BPerl%2C+Orly%3BBalbo%2C+Andrea%3BYamaguchi%2C+Hiroshi%3BHoutman%2C+Jon+C+D%3BAppella%2C+Ettore%3BSchuck%2C+Peter%3BSamelson%2C+Lawrence+E&rft.aulast=Barda-saad&rft.aufirst=Mira&rft.date=2010-07-21&rft.volume=29&rft.issue=14&rft.spage=2315&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Femboj.2010.133 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Jul 21, 2010 N1 - Document feature - References N1 - Last updated - 2014-07-19 N1 - CODEN - EMJODG DO - http://dx.doi.org/10.1038/emboj.2010.133 ER - TY - JOUR T1 - Vibrio cholerae Hemolysin Is Required for Lethality, Developmental Delay, and Intestinal Vacuolation in Caenorhabditis elegans AN - 754554651; 13317033 AB - Cholera toxin (CT) and toxin-co-regulated pili (TCP) are the major virulence factors of Vibrio cholerae O1 and O139 strains that contribute to the pathogenesis of disease during devastating cholera pandemics. However, CT and TCP negative V. cholerae strains are still able to cause severe diarrheal disease in humans through mechanisms that are not well understood. To determine the role of other virulence factors in V. cholerae pathogenesis, we used a CT and TCP independent infection model in the nematode Caenorhabditis elegans and identified the hemolysin A (hlyA) gene as a factor responsible for animal death and developmental delay. We demonstrated a correlation between the severity of infection in the nematode and the level of hemolytic activity in the V. cholerae biotypes. At the cellular level, V. cholerae infection induces formation of vacuoles in the intestinal cells in a hlyA dependent manner, consistent with the previous in vitro observations. Our data strongly suggest that HlyA is a virulence factor in C. elegans infection leading to lethality and developmental delay presumably through intestinal cytopathic changes. JF - PLoS ONE AU - Cinar, Hediye Nese AU - Kothary, Mahendra AU - Datta, Atin R AU - Tall, Ben D AU - Sprando, Robert AU - Bilecen, Kivanc AU - Yildiz, Fitnat AU - McCardell, Barbara AD - Division of Virulence Assessment, Food and Drug Administration, Laurel, Maryland, United States of America Y1 - 2010/07/13/ PY - 2010 DA - 2010 Jul 13 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 7 KW - Microbiology Abstracts B: Bacteriology KW - Biotypes KW - Data processing KW - Diarrhea KW - virulence factors KW - Infection KW - Vibrio cholerae KW - pandemics KW - hlyA gene KW - Lethality KW - Pili KW - Cholera toxin KW - Caenorhabditis elegans KW - Vacuoles KW - Intestine KW - Cholera KW - Hemolysins KW - Nematoda KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754554651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Vibrio+cholerae+Hemolysin+Is+Required+for+Lethality%2C+Developmental+Delay%2C+and+Intestinal+Vacuolation+in+Caenorhabditis+elegans&rft.au=Cinar%2C+Hediye+Nese%3BKothary%2C+Mahendra%3BDatta%2C+Atin+R%3BTall%2C+Ben+D%3BSprando%2C+Robert%3BBilecen%2C+Kivanc%3BYildiz%2C+Fitnat%3BMcCardell%2C+Barbara&rft.aulast=Cinar&rft.aufirst=Hediye&rft.date=2010-07-13&rft.volume=5&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011558 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Diarrhea; Data processing; Biotypes; virulence factors; Infection; pandemics; Lethality; hlyA gene; Cholera toxin; Pili; Vacuoles; Intestine; Cholera; Hemolysins; Vibrio cholerae; Caenorhabditis elegans; Nematoda DO - http://dx.doi.org/10.1371/journal.pone.0011558 ER - TY - JOUR T1 - Properly Folded Bacterially Expressed H1N1 Hemagglutinin Globular Head and Ectodomain Vaccines Protect Ferrets against H1N1 Pandemic Influenza Virus AN - 754552039; 13315681 AB - In the face of impending influenza pandemic, a rapid vaccine production and mass vaccination is the most effective approach to prevent the large scale mortality and morbidity that was associated with the 1918 "Spanish Flu". The traditional process of influenza vaccine production in eggs is time consuming and may not meet the demands of rapid global vaccination required to curtail influenza pandemic. Recombinant technology can be used to express the hemagglutinin (HA) of the emerging new influenza strain in a variety of systems including mammalian, insect, and bacterial cells. In this study, two forms of HA proteins derived from the currently circulating novel H1N1 A/California/07/2009 virus, HA1 (1-330) and HA (1-480), were expressed and purified from E. coli under controlled redox refolding conditions that favoured proper protein folding. However, only the recombinant HA1 (1-330) protein formed oligomers, including functional trimers that bound receptor and caused agglutination of human red blood cells. These proteins were used to vaccinate ferrets prior to challenge with the A/California/07/2009 virus. Both proteins induced neutralizing antibodies, and reduced viral loads in nasal washes. However, the HA1 (1-330) protein that had higher content of multimeric forms provided better protection from fever and weight loss at a lower vaccine dose compared with HA (1-480). Protein yield for the HA1 (1-330) ranged around 40 mg/Liter, while the HA (1-480) yield was 0.4-0.8 mg/Liter. This is the first study that describes production in bacterial system of properly folded functional globular HA1 domain trimers, lacking the HA2 transmembrane protein, that elicit potent neutralizing antibody responses following vaccination and protect ferrets from in vivo challenge. The combination of bacterial expression system with established quality control methods could provide a mechanism for rapid large scale production of influenza vaccines in the face of influenza pandemic threat. JF - PLoS ONE AU - Khurana, Surender AU - Verma, Swati AU - Verma, Nitin AU - Crevar, Corey J AU - Carter, Donald M AU - Manischewitz, Jody AU - King, Lisa R AU - Ross, Ted M AU - Golding, Hana AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland, United States of America Y1 - 2010/07/12/ PY - 2010 DA - 2010 Jul 12 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 5 IS - 7 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agglutination KW - Antibodies KW - Eggs KW - Erythrocytes KW - Fever KW - HA protein KW - Hemagglutinins KW - Influenza KW - Membrane proteins KW - Morbidity KW - Mortality KW - Protein folding KW - Quality control KW - Vaccines KW - pandemics KW - Influenza virus KW - Mustela KW - Escherichia coli KW - V 22410:Animal Diseases KW - A 01490:Miscellaneous KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754552039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Properly+Folded+Bacterially+Expressed+H1N1+Hemagglutinin+Globular+Head+and+Ectodomain+Vaccines+Protect+Ferrets+against+H1N1+Pandemic+Influenza+Virus&rft.au=Khurana%2C+Surender%3BVerma%2C+Swati%3BVerma%2C+Nitin%3BCrevar%2C+Corey+J%3BCarter%2C+Donald+M%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BRoss%2C+Ted+M%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2010-07-12&rft.volume=5&rft.issue=7&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0011548 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2013-01-25 N1 - SubjectsTermNotLitGenreText - Mortality; HA protein; Hemagglutinins; Erythrocytes; Membrane proteins; Morbidity; Eggs; Influenza; Fever; pandemics; Antibodies; Agglutination; Protein folding; Quality control; Vaccines; Influenza virus; Mustela; Escherichia coli DO - http://dx.doi.org/10.1371/journal.pone.0011548 ER - TY - CPAPER T1 - Applications of Non-Invasive Optical Methods to Activate Photodynamic Drugs Within Deep Seated Target T2 - 3rd Conference on Light Activated Tissue Regeneration and Therapy AN - 1312918870; 5997776 JF - 3rd Conference on Light Activated Tissue Regeneration and Therapy AU - Waynant, Ronald Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312918870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Conference+on+Light+Activated+Tissue+Regeneration+and+Therapy&rft.atitle=Applications+of+Non-Invasive+Optical+Methods+to+Activate+Photodynamic+Drugs+Within+Deep+Seated+Target&rft.au=Waynant%2C+Ronald&rft.aulast=Waynant&rft.aufirst=Ronald&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Conference+on+Light+Activated+Tissue+Regeneration+and+Therapy&rft.issn=&rft_id=info:doi/ L2 - http://www.engconfintl.org/10atfin.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Activity and viability of lactic acid bacteria in yogurts fortified with predigested non-germinated or germinated whole soy powder T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312866625; 5994036 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Nsofor, U AU - Ustunol, Z Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Yogurt KW - Powder KW - Soybeans KW - Lactic acid bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312866625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Activity+and+viability+of+lactic+acid+bacteria+in+yogurts+fortified+with+predigested+non-germinated+or+germinated+whole+soy+powder&rft.au=Nsofor%2C+U%3BUstunol%2C+Z&rft.aulast=Nsofor&rft.aufirst=U&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Development of a PCR assay for the detection of Zymomonas mobilis in distillers grains T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312865811; 5993546 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Rasmussen, M AU - Benahmed, F Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Grain KW - Polymerase chain reaction KW - Nucleotide sequence KW - Zymomonas mobilis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312865811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Development+of+a+PCR+assay+for+the+detection+of+Zymomonas+mobilis+in+distillers+grains&rft.au=Rasmussen%2C+M%3BBenahmed%2C+F&rft.aulast=Rasmussen&rft.aufirst=M&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Sensory attributes of yogurt fortified with predigested, nongerminated or germinated whole soy powder T2 - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AN - 1312862321; 5994037 JF - 2010 Joint Annual Meeting of the American Dairy Science Association, Poultry Science Association, Asociacion Mexicana De Produccion Animal, Canadian Society of Animal Science, and American Society of Animal Science (JAM 2010) AU - Nsofor, U AU - Ustunol, Z Y1 - 2010/07/11/ PY - 2010 DA - 2010 Jul 11 KW - Yogurt KW - Sensory properties KW - Powder KW - Soybeans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312862321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.atitle=Sensory+attributes+of+yogurt+fortified+with+predigested%2C+nongerminated+or+germinated+whole+soy+powder&rft.au=Nsofor%2C+U%3BUstunol%2C+Z&rft.aulast=Nsofor&rft.aufirst=U&rft.date=2010-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Joint+Annual+Meeting+of+the+American+Dairy+Science+Association%2C+Poultry+Science+Association%2C+Asociacion+Mexicana+De+Produccion+Animal%2C+Canadian+Society+of+Animal+Science%2C+and+American+Society+of+Animal+Science+%28JAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jtmtg.org/2010/toc.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Manufacturing Process Controls for Controlled Release Dosage Forms T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312881763; 5984966 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Shrinkant, P AU - Yu, A AU - Sloan, M Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Manufacturing industry KW - Controlled release UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312881763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Manufacturing+Process+Controls+for+Controlled+Release+Dosage+Forms&rft.au=Shrinkant%2C+P%3BYu%2C+A%3BSloan%2C+M&rft.aulast=Shrinkant&rft.aufirst=P&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Using the BCS as a Tool for Interpreting the In Vivo Relevance of In Vitro Dissolution Data in Dogs T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312879112; 5984476 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Martinez, M Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Data processing KW - Dissolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312879112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Using+the+BCS+as+a+Tool+for+Interpreting+the+In+Vivo+Relevance+of+In+Vitro+Dissolution+Data+in+Dogs&rft.au=Martinez%2C+M&rft.aulast=Martinez&rft.aufirst=M&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Quantifying Variability in Drug Absorption T2 - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AN - 1312859647; 5984415 JF - 37th Annual Meeting and Exposition of the Controlled Release Society (CRS 2010) AU - Lionberger, Robert Y1 - 2010/07/10/ PY - 2010 DA - 2010 Jul 10 KW - Absorption KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1312859647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.atitle=Quantifying+Variability+in+Drug+Absorption&rft.au=Lionberger%2C+Robert&rft.aulast=Lionberger&rft.aufirst=Robert&rft.date=2010-07-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=37th+Annual+Meeting+and+Exposition+of+the+Controlled+Release+Society+%28CRS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.controlledrelease.org/meeting/2010/program/pdfs/Programbook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - CPAPER T1 - Regulatory frameworks for nanotechnology applications in food: Are they adequate? T2 - 2010 Euroscience Open Forum (ESOF 2010) AN - 866040412; 5965934 JF - 2010 Euroscience Open Forum (ESOF 2010) AU - Thurmond, Thane Y1 - 2010/07/02/ PY - 2010 DA - 2010 Jul 02 KW - nanotechnology KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/866040412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Euroscience+Open+Forum+%28ESOF+2010%29&rft.atitle=Regulatory+frameworks+for+nanotechnology+applications+in+food%3A+Are+they+adequate%3F&rft.au=Thurmond%2C+Thane&rft.aulast=Thurmond&rft.aufirst=Thane&rft.date=2010-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Euroscience+Open+Forum+%28ESOF+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esof2010.org/programme/programme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-09 N1 - Last updated - 2012-09-05 ER - TY - JOUR T1 - A Repeat Call for the Banning of Asbestos AN - 918039039; 13640160 JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Schroeder, Jane C AU - Tilson, Hugh A AD - NIEHS and NTP, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - A280 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Asbestos KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918039039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=A+Repeat+Call+for+the+Banning+of+Asbestos&rft.au=Birnbaum%2C+Linda+S%3BSchroeder%2C+Jane+C%3BTilson%2C+Hugh+A&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2010-07-01&rft.volume=118&rft.issue=7&rft.spage=A280&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Asbestos DO - http://dx.doi.org/10.1289/ehp.1002419 ER - TY - JOUR T1 - Chrysotile Asbestos and Mesothelioma AN - 918037690; 13640161 JF - Environmental Health Perspectives AU - Lemen, Richard A AD - U.S. Public Health Service (retired), National Institute for Occupational Safety Health (retired), Canton, Georgia, Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - A282 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - Asbestos KW - mesothelioma KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918037690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Chrysotile+Asbestos+and+Mesothelioma&rft.au=Lemen%2C+Richard+A&rft.aulast=Lemen&rft.aufirst=Richard&rft.date=2010-07-01&rft.volume=118&rft.issue=7&rft.spage=A282&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1002446 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Asbestos; mesothelioma DO - http://dx.doi.org/10.1289/ehp.1002446 ER - TY - JOUR T1 - Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan AN - 904467246; 14317441 AB - Abstract not available. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Stingley, Robin L AU - Beland, Frederick A AU - Harrouk, Wafa AU - Lumpkins, Debbie L AU - Howard, Paul AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 147 EP - 171 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 28 IS - 3 SN - 1059-0501, 1059-0501 KW - Pollution Abstracts; Toxicology Abstracts KW - Toxicity KW - Reviews KW - Carcinogenesis KW - Triclosan KW - Metabolism KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904467246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Occurrence%2C+Efficacy%2C+Metabolism%2C+and+Toxicity+of+Triclosan&rft.au=Stingley%2C+Robin+L%3BBeland%2C+Frederick+A%3BHarrouk%2C+Wafa%3BLumpkins%2C+Debbie+L%3BHoward%2C+Paul&rft.aulast=Stingley&rft.aufirst=Robin&rft.date=2010-07-01&rft.volume=28&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590501.2010.504978 L2 - http://www.informaworld.com/smpp/content~db=all~content=a927101215~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Carcinogenesis; Toxicity; Triclosan; Metabolism; Reviews DO - http://dx.doi.org/10.1080/10590501.2010.504978 ER - TY - JOUR T1 - Determination of malachite green and crystal violet in processed fish products AN - 902360567; 15760194 AB - This paper presents analysis of malachite green (MG) and crystal violet (CV) residues in processed fish products. Samples were homogenized and extracted with ammonium acetate buffer and acetonitrile. The extracted residues were partitioned into dichloromethane, in situ oxidized to chromic forms with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and cleaned up on neutral alumina and propylsulfonic acid cation-exchange solid-phase extraction (SPE) cartridges. MG and CV were determined at 618 and 588 nm using HPLC with a visible detector (LC-VIS) and confirmed by LC-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The recoveries were as follows: MG (74.8-83.8%), LMG (80.0-88.4%), CV (68.6-73.9%), and LCV (85.5-90.0%). The method modified in this study has been evaluated by application in-house to a survey of 253 processed fish products. As a result of monitoring, MG and CV were positive in one shrimp and one eel sample, respectively. Our results showed that regular monitoring of these antibiotic residues is recommended for protection of public health. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Lee, Jun Bae AU - Yun Kim, Hee AU - Mi Jang, Young AU - Young Song, Ji AU - Min Woo, Sung AU - Sun Park, Mi AU - Sook Lee, Hyun AU - Kyu Lee, Soon AU - Kim, Meehye AD - Imported Food Analysis Division, Korea Food and Drug Administration, Incheon 402-835, South Korea Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 953 EP - 961 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 27 IS - 7 SN - 1944-0049, 1944-0049 KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Pollution Abstracts; Risk Abstracts KW - Risk assessment KW - Molecular structure KW - Biological surveys KW - Pollution monitoring KW - Ammonium KW - Residues KW - Catadromous species KW - Disease control KW - Mass spectrometry KW - Antibiotics KW - Public health KW - Food additives KW - Fish KW - Fishery products KW - Ammonium compounds KW - O 4080:Pollution - Control and Prevention KW - Q1 08625:Non-edible products KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/902360567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Determination+of+malachite+green+and+crystal+violet+in+processed+fish+products&rft.au=Lee%2C+Jun+Bae%3BYun+Kim%2C+Hee%3BMi+Jang%2C+Young%3BYoung+Song%2C+Ji%3BMin+Woo%2C+Sung%3BSun+Park%2C+Mi%3BSook+Lee%2C+Hyun%3BKyu+Lee%2C+Soon%3BKim%2C+Meehye&rft.aulast=Lee&rft.aufirst=Jun&rft.date=2010-07-01&rft.volume=27&rft.issue=7&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440041003705839 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Biological surveys; Molecular structure; Food additives; Disease control; Catadromous species; Antibiotics; Ammonium compounds; Public health; Fishery products; Risk assessment; Ammonium; Pollution monitoring; Residues; Mass spectrometry; Fish DO - http://dx.doi.org/10.1080/19440041003705839 ER - TY - JOUR T1 - Livestock Handling-Minimizing Worker Injuries AN - 888106821; 15523699 AB - Numerous hazards may occur on farms raising livestock. Animal contact is often ranked as the first or second leading cause of injuries on the farm. In addition to direct trauma from the animal, other injuries may occur from injection of medications, chemical splashes from cleaning the facility, and repetitive motion injuries. Exposures to toxic gases from decomposition of animal waste such as in manure pits and exposure to animal allergens may cause adverse health effects in humans. One additional consideration is the risk of developing various zoonotic infections. Human injuries happen more often when people are handling animals than during any other activity performed in pork production. The National Pork Board of the United States, in response to a request from pork producers, has developed a program designed to improve worker safety, pig welfare, and pork quality when pigs are moved for whatever reason. The objective of the Transport Quality Assurance(TM) (TQA) program is to help all those who transport, produce, or handle swine to do so in a way that is optimal for the pigs' well-being, the health of the handler, and to improve the quality of the pork produced. Understanding basic pig behavior, proper handling practices, and using proper handling equipment will help animal handling be a safe activity. This paper was prepared for the Agricultural Safety and Health Council of America/National Institute of Occupational Safety and Health Conference, "Be Safe, Be Profitable: Protecting Workers in Agriculture," January 27-28, 2010, Dallas/Fort Worth, Texas. JF - Journal of Agromedicine AU - Langley, Ricky L AU - Morrow, WEMorgan AD - North Carolina Department of Health and Human Services, Division of Public Health, Raleigh, North Carolina, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 226 EP - 235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 3 SN - 1059-924X, 1059-924X KW - Risk Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Chemical spills KW - Injuries KW - Conferences KW - USA, Texas, Dallas KW - USA, Texas, Fort Worth KW - Livestock KW - Gases KW - farms KW - Allergens KW - councils KW - USA, Texas KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888106821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Livestock+Handling-Minimizing+Worker+Injuries&rft.au=Langley%2C+Ricky+L%3BMorrow%2C+WEMorgan&rft.aulast=Langley&rft.aufirst=Ricky&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.486327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Chemical spills; Gases; Conferences; Injuries; Allergens; farms; councils; Occupational exposure; Livestock; USA, Texas, Dallas; USA, Texas; USA, Texas, Fort Worth DO - http://dx.doi.org/10.1080/1059924X.2010.486327 ER - TY - JOUR T1 - Preventing Heat-Related Illness Among Agricultural Workers AN - 888097008; 15523710 AB - Hyperthermia from exertion and environmental conditions during agricultural work manifests itself by various symptoms and may lead to death. From 1992 through 2006, 68 workers employed in crop production and related services died from heat-related illness. The crop worker fatality rate averaged 4 heat-related deaths per one million workers per year-20 times higher than the 0.2 rate for US civilian workers overall. Many of the agricultural workers who died were foreign-born. Foreign-born workers tend to have limited English language skills and often are not acclimatized to exertion in hot weather when beginning seasonal jobs. Increased recognition of heat hazards to agricultural workers, in particular, has stimulated concern among employers, workers, and public policy makers. California and Washington have led the nation in adopting workplace safety standards designed to prevent heat-related illnesses. These state regulations include new specific requirements for employer provision of drinking water, shade for rest or other sufficient means to recover from heat, worker and supervisor training, and written heat safety plans. Agricultural employers face practical challenges in fulfilling the purpose and complying with these standards. By their very nature the standards impose generic requirements in a broad range of circumstances and may not be equally protective in all agricultural work settings. It is vital that employers and supervisors have a thorough knowledge of heat illness prevention to devise and implement safety measures that suit local conditions. Ongoing risk-based assessment of current heat conditions by employers is important to this safety effort. Workers need training to avoid heat illness and recognize the symptoms in themselves and coworkers. Innovative management practices are joining time-honored approaches to controlling heat stress and strain. Research targeted to answer questions about heat accumulation and dissipation during agricultural work and audience-sensitive education to promote understanding of basic physiology and recognition of hyperthermia symptoms can aid in heat illness prevention. This review was prepared for the Agricultural Safety and Health Council of America/ National Institute for Occupational Safety and Health conference, "Be Safe, Be Profitable: Protecting Workers in Agriculture," Dallas/Fort Worth, Texas, January 27-28, 2010. JF - Journal of Agromedicine AU - Jackson, Larry L AU - Rosenberg, Howard R AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virgina, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 200 EP - 215 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 15 IS - 3 SN - 1059-924X, 1059-924X KW - Risk Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - heat tolerance KW - Mortality KW - Training KW - USA, Texas, Dallas KW - Physiology KW - Occupational safety KW - USA, Texas, Fort Worth KW - USA, Washington KW - prevention KW - USA, California KW - USA, Texas KW - Environmental conditions KW - Drinking water KW - Ethnic groups KW - ENA 06:Food & Drugs KW - R2 23090:Policy and planning KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/888097008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Preventing+Heat-Related+Illness+Among+Agricultural+Workers&rft.au=Jackson%2C+Larry+L%3BRosenberg%2C+Howard+R&rft.aulast=Jackson&rft.aufirst=Larry&rft.date=2010-07-01&rft.volume=15&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2010.487021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Mortality; heat tolerance; Training; Occupational safety; Physiology; prevention; Drinking water; Environmental conditions; Ethnic groups; USA, Washington; USA, Texas, Dallas; USA, Texas; USA, California; USA, Texas, Fort Worth DO - http://dx.doi.org/10.1080/1059924X.2010.487021 ER - TY - JOUR T1 - RT-GROG: parallelized self-calibrating GROG for real-time MRI AN - 883036347; 15255632 AB - A real-time implementation of self-calibrating Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) operator gridding for radial acquisitions is presented. Self-calibrating GRAPPA operator gridding is a parallel-imaging-based, parameter-free gridding algorithm, where coil sensitivity profiles are used to calculate gridding weights. Self-calibrating GRAPPA operator gridding's weight-set calculation and image reconstruction steps are decoupled into two distinct processes, implemented in C++ and parallelized. This decoupling allows the weights to be updated adaptively in the background while image reconstruction threads use the most recent gridding weights to grid and reconstruct images. All possible combinations of two-dimensional gridding weights GG are evaluated for m,n = {-0.5, -0.4, ..., ,0.1, ..., 0.5} and stored in a look-up table. Consequently, the per-sample two-dimensional weights calculation during gridding is eliminated from the reconstruction process and replaced by a simple look-up table access. In practice, up to 34X faster reconstruction than conventional (parallelized) self-calibrating GRAPPA operator gridding is achieved. On a 32-coil dataset of size 128 X 64, reconstruction performance is 14.5 frames per second (fps), while the data acquisition is 6.6 fps. Magn Reson Med 64:306-312, 2010. [copy 2010 Wiley-Liss, Inc. JF - Magnetic Resonance in Medicine AU - Saybasili, Haris AU - Derbyshire, J Andrew AU - Kellman, Peter AU - Griswold, Mark A AU - Ozturk, Cengizhan AU - Lederman, Robert J AU - Seiberlich, Nicole AD - Translational Medicine Branch, National Institutes of Health/National Heart, Lung and Blood Institute (NHLBI), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA, saybasilih@nhlbi.nih.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 306 EP - 312 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 64 IS - 1 SN - 1522-2594, 1522-2594 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Algorithms KW - Image processing KW - N.M.R. KW - Data acquisition KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=RT-GROG%3A+parallelized+self-calibrating+GROG+for+real-time+MRI&rft.au=Saybasili%2C+Haris%3BDerbyshire%2C+J+Andrew%3BKellman%2C+Peter%3BGriswold%2C+Mark+A%3BOzturk%2C+Cengizhan%3BLederman%2C+Robert+J%3BSeiberlich%2C+Nicole&rft.aulast=Saybasili&rft.aufirst=Haris&rft.date=2010-07-01&rft.volume=64&rft.issue=1&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=15222594&rft_id=info:doi/10.1002%2Fmrm.22351 L2 - http://onlinelibrary.wiley.com/doi/10.1002/mrm.22351/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Algorithms; Image processing; N.M.R.; Data acquisition DO - http://dx.doi.org/10.1002/mrm.22351 ER - TY - RPRT T1 - FOREWORD AN - 878683487 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF ETHINYL ESTRADIOL (CAS NO. 57-63-6) IN SPRAGUE-DAWLEY RATS (FEED STUDY) AN - 878683481; 21031006 AB - Ethinyl estradiol is a potent synthetic estrogen that is widely prescribed in oral contraceptives and is also used in the treatment of breast and prostate cancer. Ethinyl estradiol is one of a class of chemicals known as "environmental estrogens" that can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. The NTP conducted a series of studies on three such chemicals to detect if exposure over the course of multiple generations could have any cumulative effect on animals' reproductive systems or development of cancers. This report describes the results of a set of studies in which rats were exposed to ethinyl estradiol for part or all of the study period and examined at the end of two years. The study consisted of three separate study components; in each, animals were exposed to ethinyl estradiol from the time of conception and through weaning through their mothers, who were given ethinyl estradiol in their feed. In one study we gave feed containing 2, 10, or 50 parts per billion (ppb) of ethinyl estradiol to groups of 50 male and female rats from conception through two years. In the second study, groups of 50 male and female rats were given the same feed concentrations up to 20 weeks following birth, followed by untreated feed for the remainder of the two years. In the third study groups of 50 male and female rats were exposed from conception through weaning, and then given untreated feed for the duration of the study. Control animals received the same feed with no ethinyl estradiol added. Enthinyl estradiol is known to cause cancer at higher dose levels; the concentrations given in this study were below the levels of detection by chemical analysis, to determine the possible effects of trace amounts in the environment. At the end of the study tissues from more than 40 sites were examined for every animal. In all three study sets effects were seen in the uterus of female rats. The rates of squamous metaplasia increased in females exposed for two years and in females exposed from conception through weaning; endometrial hyperplasia and atypical focal hyperplasia of the uterus also were increased in females exposed for two years. Uterine stromal polyps were increased in female rats exposed from conception through 20 weeks after birth or from conception through weaning. Male rats exposed from conception through weaning had small increases in the rates of preputial gland tumors and three male rats in that study had rare mammary gland adenomas or carcinomas. We conclude that exposure to trace amounts of ethinyl estradiol during the period from conception through weaning may have been related to development of uterine stromal polyps in female rats and to preputial gland tumors and mammaiy gland tumors in male rats. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 EP - 210 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Ethinyl Estradiol KW - Rodents KW - Toxicology KW - Cancer KW - Estrogen KW - Reproductive system KW - Synthetic products KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Ethinyl Estradiol -- metabolism KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Ethinyl Estradiol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDY+OF+ETHINYL+ESTRADIOL+%28CAS+NO.+57-63-6%29+IN+SPRAGUE-DAWLEY+RATS+%28FEED+STUDY%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878683479 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-07-01&rft.volume=&rft.issue=548&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jul 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - Legal and Informal Adoption by Relatives in the U.S.: Comparative Characteristics and Well-Being from a Nationally Representative Sample International Transracial Adoption AN - 862780625 AB - A large, nationally representative sample of households is used to compare children legally adopted by relatives with those living with relatives in households that that did not include the child's biological parents (i.e., children in informal adoptions). As context, children legally and informally adopted by kin are also compared with adopted children generally and with the broader population of all U.S. children. Demographically, there were virtually no differences between children legally and informally adopted by kin, though these groups are distinct from U.S. children overall and from other adopted children. Children legally adopted by kin fared better than those adopted informally on several measures of health and well-being. Adapted from the source document. JF - Adoption Quarterly AU - Radel, Laura F AU - Bramlett, Matthew D AU - Waters, Annette AD - Office Assistant Secretary Planning Evaluation, U.S. Dept Health Human Services, Washington, DC laura.radel@hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 268 EP - 591 PB - Taylor & Francis, Philadelphia, PA VL - 13 IS - 3-4 SN - 1092-6755, 1092-6755 KW - adoption KW - relative adoption KW - kin adoption KW - foster care adoption KW - private adoption KW - Well Being KW - Households KW - Adoption KW - Parents KW - Children KW - Adopted Children KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862780625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adoption+Quarterly&rft.atitle=Legal+and+Informal+Adoption+by+Relatives+in+the+U.S.%3A+Comparative+Characteristics+and+Well-Being+from+a+Nationally+Representative+Sample+International+Transracial+Adoption&rft.au=Radel%2C+Laura+F%3BBramlett%2C+Matthew+D%3BWaters%2C+Annette&rft.aulast=Radel&rft.aufirst=Laura&rft.date=2010-07-01&rft.volume=13&rft.issue=3-4&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Adoption+Quarterly&rft.issn=10926755&rft_id=info:doi/10.1080%2F10926755.2010.537957 LA - English DB - Social Services Abstracts N1 - Date revised - 2011-04-18 N1 - Last updated - 2016-09-28 N1 - CODEN - ADQUFW N1 - SubjectsTermNotLitGenreText - Children; Well Being; Adopted Children; Households; Adoption; Parents DO - http://dx.doi.org/10.1080/10926755.2010.537957 ER - TY - JOUR T1 - Detection technologies for Bacillus anthracis: Prospects and challenges AN - 856756167; 13663480 AB - Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological agent of acute infectious disease anthrax, a lethal but rare disease of animals and humans in nature. With recent use of anthrax as a bioweapon, a number of techniques have been recently developed and evaluated to facilitate its rapid detection of B. anthracis in the environment as well as in point-of-care settings for humans suspected of exposure to the pathogen. Complex laboratory methods for B. anthracis identification are required since B. anthracis has similarities with other Bacillus species and its existence in both spore and vegetative forms. This review discusses current challenges and various improvements associated with anthrax agent detection. JF - Journal of Microbiological Methods AU - Rao, Shilpakala Sainath AU - Mohan, Ketha VK AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, United States Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 1 EP - 10 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 82 IS - 1 SN - 0167-7012, 0167-7012 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Anthrax KW - Bacillus anthracis KW - A 01300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856756167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microbiological+Methods&rft.atitle=Detection+technologies+for+Bacillus+anthracis%3A+Prospects+and+challenges&rft.au=Rao%2C+Shilpakala+Sainath%3BMohan%2C+Ketha+VK%3BAtreya%2C+Chintamani+D&rft.aulast=Rao&rft.aufirst=Shilpakala&rft.date=2010-07-01&rft.volume=82&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microbiological+Methods&rft.issn=01677012&rft_id=info:doi/10.1016%2Fj.mimet.2010.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Anthrax; Bacillus anthracis DO - http://dx.doi.org/10.1016/j.mimet.2010.04.005 ER - TY - JOUR T1 - Concurrent validity of the parent-completed Ages and Stages Questionnaires, 2nd Ed. with the Bayley Scales of Infant Development II in a low-risk sample AN - 839571094; 201101510 AB - Background This study assessed the concurrent validity of the Ages and Stages Questionnaire (ASQ) compared with Bayley Scales of Infant Development II (BSID II) amongst children aged 24 months. Methods who participated in the New York State Angler Cohort Child Development Study. Parents completed the 24-month ASQ to assess communication, personal-social, problem-solving ability, and fine and gross motor control. The BSID II was administered by a clinical psychologist at the 24-month home visit for cognitive and psychomotor assessment. The ASQ was scored using age-specific norms of <2 SDs below any domain mean to define failure. A BSID II score of <85 indicated mild or severe delay, while a score of <70 suggested a severe delay. Results Scores on the ASQ communication and personal-social domains were moderately correlated with the BSID II Mental Scale (R = 0.52, P < 0.001; R = 0.45, P < 0.01) and ASQ gross motor with the BSID II Motor Scale (R = 0.46, P < 0.01), whereas ASQ problem-solving and fine motor domains were not significantly correlated with BSID II scores. The ASQ had a sensitivity of 100% and specificity of 87% at 24 months (n = 40) for severely delayed status. Conclusions cost-effective method for clinicians and field-based researchers to reduce the number of standardized assessments required to identify developmentally delayed infants at age 24 months. Future studies should further assess the validity of the ASQs in larger, more diverse populations of infants. Adapted from the source document. JF - Child: Care, Health and Development AU - Gollenberg, A L AU - Lynch, C D AU - Jackson, L W AU - McGuinness, B M AU - Msall, M E AD - Eunice Kennedy Shriver, National Institute of Child Health and Human Development; National Institutes of Health; Department of Health and Human Services; Rockville, MD Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 485 EP - 490 PB - Blackwell Publishing, Oxford UK VL - 36 IS - 4 SN - 0305-1862, 0305-1862 KW - child development developmental screening diagnostic tests sensitivity and specificity KW - Fines KW - Cost effectiveness KW - Problem solving KW - Child development KW - Clinical psychologists KW - Infants KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839571094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child%3A+Care%2C+Health+and+Development&rft.atitle=Concurrent+validity+of+the+parent-completed+Ages+and+Stages+Questionnaires%2C+2nd+Ed.+with+the+Bayley+Scales+of+Infant+Development+II+in+a+low-risk+sample&rft.au=Gollenberg%2C+A+L%3BLynch%2C+C+D%3BJackson%2C+L+W%3BMcGuinness%2C+B+M%3BMsall%2C+M+E&rft.aulast=Gollenberg&rft.aufirst=A&rft.date=2010-07-01&rft.volume=36&rft.issue=4&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Child%3A+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fj.1365-2214.2009.01041.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - CCHDDH N1 - SubjectsTermNotLitGenreText - Infants; Fines; Problem solving; Clinical psychologists; Cost effectiveness; Child development DO - http://dx.doi.org/10.1111/j.1365-2214.2009.01041.x ER - TY - JOUR T1 - Introduction: The Recovery Community Services Program AN - 758125112; 201010833 AB - This article traces the history of the Recovery Community Services Program (RCSP) from its inception in the Substance Abuse Mental Health Services Administration/Center for Substance Abuse Treatment (SAMHSA/CSAT) 1998 vision of communities of recovery engaged in the public dialogue about addiction, treatment, and recovery through the 2002 programmatic refocus onto the provision of social supports for recovery, designed and delivered by people who share the experience of addiction and recovery, that is, peers. It focuses on the role of peer-to-peer recovery support services in an evolving recovery-oriented system of care, lessons learned as the grant program has matured, and continuing challenges in this latest chapter of the ongoing history of the relationship between communities of recovery and formal systems of care. Following articles represent how these principles are embodied in RCSP communities across the nation. Adapted from the source document. JF - Alcoholism Treatment Quarterly AU - Kaplan, Linda AU - Nugent, Catherine AU - Baker, Marsha AU - Clark, H Westley AU - Veysey, Bonita M AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 244 EP - 255 PB - Haworth/Taylor & Francis Group, Philadephia, PA VL - 28 IS - 3 SN - 0734-7324, 0734-7324 KW - Peers KW - Substance Abuse KW - Rehabilitation KW - Social Support KW - Community Services KW - Mental Health Services KW - Addiction KW - Treatment KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758125112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism+Treatment+Quarterly&rft.atitle=Introduction%3A+The+Recovery+Community+Services+Program&rft.au=Kaplan%2C+Linda%3BNugent%2C+Catherine%3BBaker%2C+Marsha%3BClark%2C+H+Westley%3BVeysey%2C+Bonita+M&rft.aulast=Kaplan&rft.aufirst=Linda&rft.date=2010-07-01&rft.volume=28&rft.issue=3&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Alcoholism+Treatment+Quarterly&rft.issn=07347324&rft_id=info:doi/10.1080%2F07347324.2010.488522 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 15 N1 - Last updated - 2016-09-28 N1 - CODEN - ATQUE7 N1 - SubjectsTermNotLitGenreText - Rehabilitation; Addiction; Substance Abuse; Community Services; Treatment; Mental Health Services; Peers; Social Support DO - http://dx.doi.org/10.1080/07347324.2010.488522 ER - TY - JOUR T1 - Work Schedules and Health Behavior Outcomes at a Large Manufacturer AN - 754901377; 13554453 AB - There is evidence that work schedules may influence rates of unhealthy behaviors, suggesting that addressing work schedule challenges may improve health. Health Risk Assessment (HRA) survey responses were collected during 2000-2008 in a multinational chemical and coatings manufacturer. Responses of 26,442 were sufficiently complete for analysis. Rates of smoking, lack of exercise, moderate to high alcohol use, obesity (BMI.30), and short sleep duration were compared by work schedule type (day, night, or rotating shift) and daily work hours (8, 10, or 12 h). Prevalence rate ratios (RRs) were calculated, adjusting for age group, sex, marital/living status, job tenure, and occupational group. The reference group was 8-h day shift employees. Overall prevalence rates were: sleep duration of 6 h or less per night 47%, smoking 17.3%, no exercise 22.0%, BMI.30 28.3%, and moderate to heavy alcohol consumption 22.2%. Statistically significant RRs include the following: Short sleep duration: 10 h rotating shift (RR=1.6), 12 h day and 12 h rotating shifts (RR=1.3); Smoking: 12 h day and rotating shifts (RR=1.6), 10 and 12 h night and 8 h rotating shift (RR=1.4); No exercise: 8, 10, and 12 h rotating shifts (RR=1.2 to 1.3), 12 h day schedules (RR=1.3). Obesity (BMI.30): 8 and 10 h night shifts (RR=1.3 and 1.4, respectively). JF - Industrial Health AU - Bushnell, P T AU - Colombi, A AU - Caruso, C C AU - Tak, S W AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS R17, Cincinnati, Ohio 45226, USA, PLB4@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 395 EP - 405 VL - 48 IS - 4 SN - 0019-8366, 0019-8366 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Smoking KW - Alcohol KW - Age KW - Behavior KW - obesity KW - marriage KW - working conditions KW - Working conditions KW - Coatings KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754901377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Work+Schedules+and+Health+Behavior+Outcomes+at+a+Large+Manufacturer&rft.au=Bushnell%2C+P+T%3BColombi%2C+A%3BCaruso%2C+C+C%3BTak%2C+S+W&rft.aulast=Bushnell&rft.aufirst=P&rft.date=2010-07-01&rft.volume=48&rft.issue=4&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Alcohol; Smoking; Age; Behavior; obesity; marriage; Working conditions; working conditions; Coatings ER - TY - JOUR T1 - Symptoms of Infectious Diseases in Travelers with Diabetes Mellitus: A Prospective Study With Matched Controls AN - 754868398; 13192039 AB - Background. Travelers with diabetes mellitus to developing countries are thought to have symptomatic infectious diseases more often and longer than travelers without diabetes. Evidence for this is needed. This study evaluates whether travelers with diabetes are at increased risk of symptomatic infectious diseases. JF - Journal of Travel Medicine AU - Baaten, Gijs G AU - Roukens, Anna H AU - Geskus, Ronald B AU - Kint, JoanA AU - Coutinho, Roel A AU - Sonder, Gerard J AU - van den Hoek, Anneke AD - *Department of Infectious Diseases, Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 256 EP - 263 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 17 IS - 4 SN - 1195-1982, 1195-1982 KW - Risk Abstracts KW - Travel KW - diabetes mellitus KW - Developing countries KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754868398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Travel+Medicine&rft.atitle=Symptoms+of+Infectious+Diseases+in+Travelers+with+Diabetes+Mellitus%3A+A+Prospective+Study+With+Matched+Controls&rft.au=Baaten%2C+Gijs+G%3BRoukens%2C+Anna+H%3BGeskus%2C+Ronald+B%3BKint%2C+JoanA%3BCoutinho%2C+Roel+A%3BSonder%2C+Gerard+J%3Bvan+den+Hoek%2C+Anneke&rft.aulast=Baaten&rft.aufirst=Gijs&rft.date=2010-07-01&rft.volume=17&rft.issue=4&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Travel+Medicine&rft.issn=11951982&rft_id=info:doi/10.1111%2Fj.1708-8305.2010.00423.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Travel; diabetes mellitus; Developing countries DO - http://dx.doi.org/10.1111/j.1708-8305.2010.00423.x ER - TY - JOUR T1 - Egg white as a blood coagulation surrogate. AN - 754147185; pmid-20649242 AB - Egg white, a protein-containing solution, is characterized as a blood coagulation surrogate for the acoustical and thermal evaluation of therapeutic ultrasound, especially high intensity focused ultrasound (HIFU) devices. Physical properties, including coagulation temperature, frequency dependent attenuation, sound speed, viscosity, and thermal properties, were measured as a function of temperature (20-95 degrees C). Thermal coagulation and attenuation (5-12 and 1 MHz) of cow blood, pig blood, and human blood also were assessed and compared with egg white. For a 30 s thermal exposure, both egg white and blood samples (3 mm thickness) started to denature at 65 degrees C and coagulate into an elastic gel at 85 degrees C. The attenuation of egg white was found to be similar to that of the blood samples, having values of 0.23f(1.09), 1.58f(0.61), and 2.7f(0.5) dB/cm at 20, 75, and 95 degrees C, respectively. This significant attenuation increase with temperature was determined to be caused mainly by bubble cavity formation. The other temperature-dependent parameters are also similar to the reported values for blood. These properties make egg white a potentially useful bench testing tool for the safety and efficacy evaluation of therapeutic ultrasound devices. JF - The Journal of the Acoustical Society of America AU - Liu, Yunbo AU - Maruvada, Subha AU - Herman, Bruce A AU - Harris, Gerald R AD - Center for Devices and Radiological Health, Food and Drug Administration, Building 62, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, USA. yxl@cdrh.fda.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 480 EP - 489 VL - 128 IS - 1 SN - 0001-4966, 0001-4966 KW - Index Medicus KW - National Library of Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754147185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+the+Acoustical+Society+of+America&rft.atitle=Egg+white+as+a+blood+coagulation+surrogate.&rft.au=Liu%2C+Yunbo%3BMaruvada%2C+Subha%3BHerman%2C+Bruce+A%3BHarris%2C+Gerald+R&rft.aulast=Liu&rft.aufirst=Yunbo&rft.date=2010-07-01&rft.volume=128&rft.issue=1&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-08-05 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Paving the Road to Mental Health Recovery AN - 754139345; 201022956 AB - In this poignant, insightful, and timely commentary by Larry Davidson and his colleagues, the authors profile individuals who suggest that it would be useful to have a "map" to guide them back from mental illnesses to a normal life. "Map" is a wonderful metaphor for the journey of mental health recovery-a journey of healing and transformation that enables individuals with mental health problems to live in communities of their choice while striving to achieve their full potential. Adapted from the source document. JF - Psychiatry AU - Power, A Kathryn AD - 1 Choke Cherry Road, Rockville, MD 20857 kathryn.power@samhsa.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 114 EP - 117 PB - The Guilford Press VL - 73 IS - 2 SN - 0033-2747, 0033-2747 KW - Healing KW - Mental illness KW - Colleagues KW - Recovery KW - Psychiatric disorders KW - Mental health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754139345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry&rft.atitle=Paving+the+Road+to+Mental+Health+Recovery&rft.au=Power%2C+A+Kathryn&rft.aulast=Power&rft.aufirst=A&rft.date=2010-07-01&rft.volume=73&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Psychiatry&rft.issn=00332747&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - CODEN - PSYCAB N1 - SubjectsTermNotLitGenreText - Mental health; Mental illness; Colleagues; Healing; Recovery; Psychiatric disorders ER - TY - JOUR T1 - Reservoir diagnosis of longwall gobs through drawdown tests and decline curve analyses of gob gas venthole productions AN - 753851952; 2010-070243 JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Dougherty, Heather N AU - Karacan, C Ozgen AU - Goodman, Gerrit V R Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 851 EP - 857 PB - Elsevier, Oxford-New York VL - 47 IS - 5 SN - 1365-1609, 1365-1609 KW - mining KW - monitoring KW - methane KW - geologic hazards KW - underground mining KW - aliphatic hydrocarbons KW - alkanes KW - porosity KW - rock mechanics KW - fractures KW - organic compounds KW - longwall mining KW - hydrocarbons KW - reservoir properties KW - permeability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753851952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Reservoir+diagnosis+of+longwall+gobs+through+drawdown+tests+and+decline+curve+analyses+of+gob+gas+venthole+productions&rft.au=Dougherty%2C+Heather+N%3BKaracan%2C+C+Ozgen%3BGoodman%2C+Gerrit+V+R&rft.aulast=Dougherty&rft.aufirst=Heather&rft.date=2010-07-01&rft.volume=47&rft.issue=5&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2010.04.010 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2010-01-01 N1 - Number of references - 21 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; fractures; geologic hazards; hydrocarbons; longwall mining; methane; mining; monitoring; organic compounds; permeability; porosity; reservoir properties; rock mechanics; underground mining DO - http://dx.doi.org/10.1016/j.ijrmms.2010.04.010 ER - TY - JOUR T1 - Estimation of the biodynamic responses distributed at fingers and palm based on the total response of the hand-arm system AN - 753668946; 13211587 AB - The major objective of this study is to develop a modeling method for estimating the biodynamic responses distributed at the fingers and the palm of the hand based on the total driving-point mechanical impedance of the entire hand-arm system. A five degrees-of-freedom (DOF) model with a set of constraints proposed in this study was used in the estimation. Three sets of mechanical impedance data measured at the fingers and palm of the hand were used to examine the validity of the proposed method. The estimated response distributed at the palm was consistent with the measured data even when the real part of the impedance alone was used in the modeling (coefficient of correlation, r super(2) >= 0.902). Better agreements between the estimated and measured responses were obtained (r super(2) >= 0.929) when the magnitude and phase of the total impedance or the magnitude alone were used in the modeling estimation. In each case, the estimated response distributed at the fingers was also reliably correlated with the experimental data (r super(2) >= 0.726) but it was not as consistent with the experimental data as that distributed at the palm. The applications of the proposed method were also demonstrated using five other sets of reported experimental data. This study also demonstrated that the modeling method may also be used to assess the quality of the experimental data in some cases. As a special application of the acceptable data identified in this study, this study also defined a 2-DOF model for the construction of a hand-arm simulator for tool tests. The results of this study and the proposed modeling method are expected to contribute to the revision of ISO 10068 (1998). Relevance to industry - Prolonged exposure to intensive tool vibration could cause hand-arm vibration syndrome (HAVS). An effective approach to reduce the HAVS is to reduce the intensity of the vibration exposure. The proposed modeling method and the results of this study can be used to help develop better tools and anti-vibration devices for reducing the exposure. The modeling study can also be used to help develop the location-specific frequency weightings for assessing the risk of the location-specific disorders induced from the hand-transmitted vibration exposure. JF - International Journal of Industrial Ergonomics AU - Dong, Ren G AU - Rakheja, Subhash AU - McDowell, Thomas W AU - Welcome, Daniel E AU - Wu, John Z AD - Engineering & Control Technology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS L-2027, Morgantown, WV 26505, USA, rkd6@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 425 EP - 436 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 40 IS - 4 SN - 0169-8141, 0169-8141 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Vibration KW - hand-arm vibration syndrome KW - Ergonomics KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753668946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Estimation+of+the+biodynamic+responses+distributed+at+fingers+and+palm+based+on+the+total+response+of+the+hand-arm+system&rft.au=Dong%2C+Ren+G%3BRakheja%2C+Subhash%3BMcDowell%2C+Thomas+W%3BWelcome%2C+Daniel+E%3BWu%2C+John+Z&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2010-07-01&rft.volume=40&rft.issue=4&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2010.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Vibration; hand-arm vibration syndrome; Occupational exposure; Ergonomics DO - http://dx.doi.org/10.1016/j.ergon.2010.02.001 ER - TY - JOUR T1 - Multiplexed identification of different fish species by detection of parvalbumin, a common fish allergen gene: a DNA application of multi-analyte profiling (xMAPTM) technology AN - 753653106; 13324782 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Hildebrandt, Sabine AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Bioanalytical Chemistry, 5100 Paint Branch Parkway, College Park, MD 20740, USA, s-hildebrandt@gmx.net PY - 2010 SP - 1787 EP - 1796 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 397 IS - 5 SN - 1618-2642, 1618-2642 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Population genetics KW - Genes KW - Allergens KW - Profiling KW - DNA KW - Parvalbumin KW - Q5 08502:Methods and instruments KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753653106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Multiplexed+identification+of+different+fish+species+by+detection+of+parvalbumin%2C+a+common+fish+allergen+gene%3A+a+DNA+application+of+multi-analyte+profiling+%28xMAPTM%29+technology&rft.au=Hildebrandt%2C+Sabine&rft.aulast=Hildebrandt&rft.aufirst=Sabine&rft.date=2010-07-01&rft.volume=397&rft.issue=5&rft.spage=1787&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-010-3760-2 L2 - http://www.springerlink.com/content/g20486k78686451t/?p=168a223c7a6c478ba9a9dc22cda43de5&pi=20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Population genetics; Genes; Profiling; DNA; Allergens; Parvalbumin DO - http://dx.doi.org/10.1007/s00216-010-3760-2 ER - TY - JOUR T1 - A BOUNDING ESTIMATE OF NEUTRON DOSE BASED ON MEASURED PHOTON DOSE AROUND SINGLE PASS REACTORS AT THE HANFORD SITE AN - 746314607; 13196308 AB - Neutron and photon radiation survey records have been used to evaluate and develop a neutron to photon (NP) ratio to reconstruct neutron doses to workers around Hanford's single pass reactors that operated from 1945 to 1972. A total of 5,773 paired neutron and photon measurements extracted from 57 boxes of survey records were used in the development of the NP ratio. The development of the NP ratio enables the use of the recorded dose from an individual's photon dosimeter badge to be used to estimate the unmonitored neutron dose. The Pearson rank correlation between the neutron and photon measurements was 0.71. The NP ratio best fit a lognormal distribution with a geometric mean (GM) of 0.8, a geometric standard deviation (GSD) of 2.95, and the upper 95 super(th)% of this distribution was 4.75. An estimate of the neutron dose based on this NP ratio is considered bounding due to evidence that up to 70% of the total photon exposure received by workers around the single pass reactors occurs during shutdown maintenance and refueling activities when there is no significant neutron exposure. Thus when this NP ratio is applied to the total measured photon dose from an individual film badge dosimeter, the resulting neutron dose is considered bounded. JF - Health Physics AU - Taulbee, T D AU - Glover, SE AU - Macievic, G V AU - Hunacek, M AU - Smith, C AU - DeBord, G W AU - Morris, D AU - Fix, J AD - National Institute for Occupational Safety and Health (NIOSH), Office of Compensation Analysis and Support (OCAS), Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, ttaulbee@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 26 EP - 38 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 99 IS - 1 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Nuclear power plants KW - Occupational exposure KW - Maintenance KW - USA, Washington, Hanford Site KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746314607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=A+BOUNDING+ESTIMATE+OF+NEUTRON+DOSE+BASED+ON+MEASURED+PHOTON+DOSE+AROUND+SINGLE+PASS+REACTORS+AT+THE+HANFORD+SITE&rft.au=Taulbee%2C+T+D%3BGlover%2C+SE%3BMacievic%2C+G+V%3BHunacek%2C+M%3BSmith%2C+C%3BDeBord%2C+G+W%3BMorris%2C+D%3BFix%2C+J&rft.aulast=Taulbee&rft.aufirst=T&rft.date=2010-07-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0b013e3181d4ee20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - Nuclear power plants; Maintenance; Occupational exposure; USA, Washington, Hanford Site DO - http://dx.doi.org/10.1097/HP.0b013e3181d4ee20 ER - TY - JOUR T1 - Prevalence, characterization and clonal analysis of Escherichia coli O157: non-H7 serotypes that carry eae alleles AN - 746232693; 13057962 AB - AbstractWe examined O157:non-H7 strains isolated from various sources and geographical locations and found 15-57 strains to carry eae alleles, including a, b, e and -d, suggesting that these strains may be prevalent. All strains were serologically and genetically confirmed to be O157, but none were the H7 serotype or carried any trait virulence factors of the Escherichia coli O157:H7 serotype. Genetic H typing of the eae-positive strains showed that the a-eae-bearing strain was H45, while the b- and e-eae strains were H16 and the -d-eae strains were H39. The b- and e-eae-bearing O157:H16 strains shared 690% pulsed-field gel electrophoresis (PFGE) similarity and were distinct from the other strains that had other eae alleles. Interestingly, an e-eae O157:H16 strain isolated from meat in France shared PFGE similarity to the O157:H16 strains from water in the United States. Multilocus sequence typing showed that there is clonal diversity within the O157 serogroup, as some O157:non-H7 strains clustered with EPEC clonal groups, while others clustered within the ST-171 group of diverse strains and serotypes that had not previously included any strains from the O157 serogroup. Clonal analysis also showed that none of the eae-positive O157:non-H7 strains we examined were closely related to the pathogenic O157:H7 serotype. JF - FEMS Microbiology Letters AU - Feng, Peter CH AU - Keys, Christine AU - Lacher, David AU - Monday, Steven R AU - Shelton, Dan AU - Rozand, Christine AU - Rivas, Marta AU - Whittam, Thomas AD - 1Division of Microbiology, FDA, College Park, MD, USA Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 62 EP - 67 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 308 IS - 1 SN - 0378-1097, 0378-1097 KW - Microbiology Abstracts B: Bacteriology KW - Escherichia coli KW - O157:non-H7 KW - eae alleles KW - clonality KW - Meat KW - Geographical distribution KW - Serotypes KW - Typing KW - virulence factors KW - Pulsed-field gel electrophoresis KW - Experimental allergic encephalomyelitis KW - multilocus sequence typing KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746232693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Prevalence%2C+characterization+and+clonal+analysis+of+Escherichia+coli+O157%3A+non-H7+serotypes+that+carry+eae+alleles&rft.au=Feng%2C+Peter+CH%3BKeys%2C+Christine%3BLacher%2C+David%3BMonday%2C+Steven+R%3BShelton%2C+Dan%3BRozand%2C+Christine%3BRivas%2C+Marta%3BWhittam%2C+Thomas&rft.aulast=Feng&rft.aufirst=Peter&rft.date=2010-07-01&rft.volume=308&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1111%2Fj.1574-6968.2010.01990.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Meat; Geographical distribution; Typing; Serotypes; virulence factors; Pulsed-field gel electrophoresis; Experimental allergic encephalomyelitis; multilocus sequence typing; Escherichia coli DO - http://dx.doi.org/10.1111/j.1574-6968.2010.01990.x ER - TY - JOUR T1 - Workplace spirometry monitoring for respiratory disease prevention: a methods review AN - 745723225; 13196776 AB - This report reviews methods applicable in workplace spirometry monitoring for the identification of individuals with excessive lung function decline. Specific issues addressed include 1) maintaining longitudinal spirometry data precision at an acceptable level so that declines due to adverse physiological processes in the lung can be readily detected in an individual; 2) applying interpretative strategies that have a high likelihood of identifying workers at risk of developing lung function impairment; and 3) enhancing effectiveness of spirometry monitoring for intervention and disease prevention. Applications in ongoing computerized spirometry monitoring programs are described that demonstrate approaches to improving spirometry data precision and quality, and facilitating informed decision-making on disease prevention. JF - International Journal of Tuberculosis and Lung Disease AU - Hnizdo, E AU - Glindmeyer, H W AU - Petsonk, EL AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA, ehnizdo@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 796 EP - 805 VL - 14 IS - 7 SN - 1027-3719, 1027-3719 KW - Risk Abstracts; Health & Safety Science Abstracts KW - tuberculosis KW - Mycobacterium KW - Lung KW - Reviews KW - intervention KW - Physiology KW - prevention KW - Respiratory function KW - Occupational health KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745723225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Workplace+spirometry+monitoring+for+respiratory+disease+prevention%3A+a+methods+review&rft.au=Hnizdo%2C+E%3BGlindmeyer%2C+H+W%3BPetsonk%2C+EL&rft.aulast=Hnizdo&rft.aufirst=E&rft.date=2010-07-01&rft.volume=14&rft.issue=7&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - tuberculosis; Lung; intervention; Reviews; Physiology; prevention; Respiratory function; Occupational health; Mycobacterium ER - TY - JOUR T1 - Effects of fire fighter protective ensembles on mobility and performance AN - 745713349; 12984665 AB - Many studies have shown that fire fighter turnout gear and equipment may restrict mobility. The restriction of movement is usually due to a decrease in range of motion (ROM). It is important to know how much the decrease in ROM affects performance. The aim of this study was to determine the effects of fire fighter protective ensembles on mobility and performance by measuring static and dynamic range of motion (ROM) and job-related tasks. Eight healthy adults (5 males, 3 females), aged 20-40 years, participated in this study. The study consisted of measuring a battery of motions and fire fighter specific tasks while wearing a standard fire fighter ensemble (SE) or regular light clothing (baseline or BL). Several BL ROM tests were significantly (p < 0.05) different from the SE test, including a decrease in shoulder flexion, cervical rotation and flexion, trunk lateral flexion, and stand and reach. There was a significant decrease in time from SE to baseline performing the one-arm search task and object lift. These overall findings support the need for a comprehensive ergonomic evaluation of protective clothing systems to ascertain human factors issues. The development of a Standard Ergonomics Test Practice for further use in laboratories that conduct personal protective systems evaluations using human test subjects is recommended. JF - Applied Ergonomics AU - Coca, Aitor AU - Williams, WJon AU - Roberge, Raymond J AU - Powell, Jeffrey B AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, USA, esq6@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 636 EP - 641 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 41 IS - 4 SN - 0003-6870, 0003-6870 KW - Health & Safety Science Abstracts KW - Fires KW - Protective clothing KW - Mobility KW - Human factors KW - Ergonomics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745713349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Effects+of+fire+fighter+protective+ensembles+on+mobility+and+performance&rft.au=Coca%2C+Aitor%3BWilliams%2C+WJon%3BRoberge%2C+Raymond+J%3BPowell%2C+Jeffrey+B&rft.aulast=Coca&rft.aufirst=Aitor&rft.date=2010-07-01&rft.volume=41&rft.issue=4&rft.spage=636&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2010.01.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fires; Protective clothing; Mobility; Human factors; Ergonomics DO - http://dx.doi.org/10.1016/j.apergo.2010.01.001 ER - TY - JOUR T1 - Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. AN - 733567235; 20305089 AB - Smith-Lemli-Opitz syndrome (SLOS) and lathosterolosis are malformation syndromes with cognitive deficits caused by mutations of 7-dehydrocholesterol reductase (DHCR7) and lathosterol 5-desaturase (SC5D), respectively. DHCR7 encodes the last enzyme in the Kandutsch-Russel cholesterol biosynthetic pathway, and impaired DHCR7 activity leads to a deficiency of cholesterol and an accumulation of 7-dehydrocholesterol. SC5D catalyzes the synthesis of 7-dehydrocholesterol from lathosterol. Impaired SC5D activity leads to a similar deficiency of cholesterol but an accumulation of lathosterol. Although the genetic and biochemical causes underlying both syndromes are known, the pathophysiological processes leading to the developmental defects remain unclear. To study the pathophysiological mechanisms underlying SLOS and lathosterolosis neurological symptoms, we performed quantitative proteomics analysis of SLOS and lathosterolosis mouse brain tissue and identified multiple biological pathways affected in Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) E18.5 embryos. These include alterations in mevalonate metabolism, apoptosis, glycolysis, oxidative stress, protein biosynthesis, intracellular trafficking, and cytoskeleton. Comparison of proteome alterations in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) brain tissues helps elucidate whether perturbed protein expression was due to decreased cholesterol or a toxic effect of sterol precursors. Validation of the proteomics results confirmed increased expression of isoprenoid and cholesterol synthetic enzymes. This alteration of isoprenoid synthesis may underlie the altered posttranslational modification of Rab7, a small GTPase that is functionally dependent on prenylation with geranylgeranyl, that we identified and validated in this study. These data suggested that although cholesterol synthesis is impaired in both Dhcr7(Delta3-5/Delta3-5) and Sc5d(-/-) embryonic brain tissues the synthesis of nonsterol isoprenoids may be increased and thus contribute to SLOS and lathosterolosis pathology. This proteomics study has provided insight into the pathophysiological mechanisms of SLOS and lathosterolosis, and understanding these pathophysiological changes will help guide clinical therapy for SLOS and lathosterolosis. JF - Molecular & cellular proteomics : MCP AU - Jiang, Xiao-Sheng AU - Backlund, Peter S AU - Wassif, Christopher A AU - Yergey, Alfred L AU - Porter, Forbes D AD - NICHD, National Institutes of Health, United States Department of Health and Human Services, Bethesda, Maryland 20892, USA. jiangx@mail.nih.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 1461 EP - 1475 VL - 9 IS - 7 KW - rab7 protein KW - 152989-05-4 KW - lathosterol KW - 80-99-9 KW - Cholesterol KW - 97C5T2UQ7J KW - lathosterol delta-5-dehydrogenase KW - EC 1.14.21.6 KW - Oxidoreductases Acting on CH-CH Group Donors KW - EC 1.3.- KW - 7-dehydrocholesterol reductase KW - EC 1.3.1.21 KW - Caspase 3 KW - EC 3.4.22.- KW - rab GTP-Binding Proteins KW - EC 3.6.5.2 KW - rab5 GTP-Binding Proteins KW - Mevalonic Acid KW - S5UOB36OCZ KW - Index Medicus KW - Molecular Structure KW - Animals KW - rab5 GTP-Binding Proteins -- metabolism KW - Enzyme Activation KW - Mice KW - Mice, Knockout KW - Brain -- enzymology KW - Mevalonic Acid -- metabolism KW - Molecular Sequence Data KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - rab GTP-Binding Proteins -- metabolism KW - Female KW - Caspase 3 -- metabolism KW - Smith-Lemli-Opitz Syndrome -- metabolism KW - Proteomics -- methods KW - Metabolic Networks and Pathways -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- genetics KW - Cholesterol -- biosynthesis KW - Cholesterol -- metabolism KW - Smith-Lemli-Opitz Syndrome -- genetics KW - Oxidoreductases Acting on CH-CH Group Donors -- deficiency KW - Smith-Lemli-Opitz Syndrome -- pathology KW - Cholesterol -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733567235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+%26+cellular+proteomics+%3A+MCP&rft.atitle=Quantitative+proteomics+analysis+of+inborn+errors+of+cholesterol+synthesis%3A+identification+of+altered+metabolic+pathways+in+DHCR7+and+SC5D+deficiency.&rft.au=Jiang%2C+Xiao-Sheng%3BBacklund%2C+Peter+S%3BWassif%2C+Christopher+A%3BYergey%2C+Alfred+L%3BPorter%2C+Forbes+D&rft.aulast=Jiang&rft.aufirst=Xiao-Sheng&rft.date=2010-07-01&rft.volume=9&rft.issue=7&rft.spage=1461&rft.isbn=&rft.btitle=&rft.title=Molecular+%26+cellular+proteomics+%3A+MCP&rft.issn=1535-9484&rft_id=info:doi/10.1074%2Fmcp.M900548-MCP200 LA - 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Last updated - 2017-01-18 DO - http://dx.doi.org/10.1074/mcp.M900548-MCP200 ER - TY - JOUR T1 - Cocaine responsiveness or anhedonia in rats treated with methylphenidate during adolescence. AN - 733561045; 20347964 AB - Methylphenidate (MPH) treatment in boys diagnosed with ADHD is reported to decrease the risk of drug abuse in adulthood. Similarly, MPH treatment appears to decrease the cocaine preference of male rats during conditioned place preference (CPP) tests. However, the effects of MPH treatment on later drug use of girls/women or CPP in female rodents have not been fully examined, nor have a clinically-relevant MPH dose and/or administration route been thoroughly studied. Here, Sprague-Dawley rats (n=34/sex/treatment) were treated orally 3x/day on postnatal days (PNDs) 29-50 with water or 3mg MPH/kg, a dose producing serum levels within the human clinical range. CPP assessments to cocaine (10 mg/kg, ip) (PNDs 62-71) indicated MPH-treated rats were less active during pre- and postconditioning sessions (p<.04), but there were no significant MPH-related differences in conditioning strength. Baseline open field activity at PND 84 indicated that MPH-treated females were more active than same-sex controls (p<.05). A cocaine challenge (10 mg/kg, ip) elevated activity similarly in MPH-treated and controls of both sexes. As an anhedonia measure, saccharin solution intake on PNDs 87-90 indicated no significant MPH effects. Estrous cycle phase did not appear to affect cocaine response during CPP or open field assessments. Hormonal levels at PND 90 indicated 63% higher corticosterone levels in MPH-treated females relative to same-sex controls (p<.05), a finding that deserves further investigation. These results address some of the major issues surrounding animal models of MPH treatment and provide additional support for a lack of severe long-term behavioral effects of adolescent MPH. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Boctor, Sherin Y AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States. Sherry.Ferguson@fda.hhs.gov PY - 2010 SP - 432 EP - 442 VL - 32 IS - 4 KW - Triiodothyronine KW - 06LU7C9H1V KW - Methylphenidate KW - 207ZZ9QZ49 KW - Testosterone KW - 3XMK78S47O KW - Estradiol KW - 4TI98Z838E KW - Cocaine KW - I5Y540LHVR KW - Thyroxine KW - Q51BO43MG4 KW - Corticosterone KW - W980KJ009P KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Age Factors KW - Sex Factors KW - Triiodothyronine -- blood KW - Thyroxine -- blood KW - Hydrocortisone -- blood KW - Rats KW - Estrous Cycle KW - Rats, Sprague-Dawley KW - Estradiol -- blood KW - Corticosterone -- blood KW - Exploratory Behavior -- drug effects KW - Testosterone -- blood KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Female KW - Male KW - Methylphenidate -- pharmacology KW - Choice Behavior -- drug effects KW - Cocaine -- pharmacology KW - Food Preferences -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733561045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Cocaine+responsiveness+or+anhedonia+in+rats+treated+with+methylphenidate+during+adolescence.&rft.au=Ferguson%2C+Sherry+A%3BBoctor%2C+Sherin+Y&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2010-07-01&rft.volume=32&rft.issue=4&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2010.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-07 N1 - Date created - 2010-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2010.03.007 ER - TY - JOUR T1 - Regulatory use of computational toxicology tools and databases at the United States Food and Drug Administration's Office of Food Additive Safety. AN - 733375731; 20491519 AB - Over 10 years ago, the Office of Food Additive Safety (OFAS) in the FDA's Center for Food Safety and Applied Nutrition implemented the formal use of structure-activity relationship analysis and quantitative structure-activity relationship (QSAR) analysis in the premarket review of food-contact substances. More recently, OFAS has implemented the use of multiple QSAR software packages and has begun investigating the use of metabolism data and metabolism predictive models in our QSAR evaluations of food-contact substances. In this article, we provide an overview of the programs used in OFAS as well as a perspective on how to apply multiple QSAR tools in the review process of a new food-contact substance. JF - Expert opinion on drug metabolism & toxicology AU - Arvidson, Kirk B AU - Chanderbhan, Ronald AU - Muldoon-Jacobs, Kristi AU - Mayer, Julie AU - Ogungbesan, Adejoke AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, HFS-275, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Kirk.Arvidson@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 793 EP - 796 VL - 6 IS - 7 KW - Food Additives KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Safety KW - Toxicology -- legislation & jurisprudence KW - Food Additives -- adverse effects KW - Computational Biology -- methods KW - Databases, Factual -- legislation & jurisprudence KW - Computational Biology -- legislation & jurisprudence KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733375731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Regulatory+use+of+computational+toxicology+tools+and+databases+at+the+United+States+Food+and+Drug+Administration%27s+Office+of+Food+Additive+Safety.&rft.au=Arvidson%2C+Kirk+B%3BChanderbhan%2C+Ronald%3BMuldoon-Jacobs%2C+Kristi%3BMayer%2C+Julie%3BOgungbesan%2C+Adejoke&rft.aulast=Arvidson&rft.aufirst=Kirk&rft.date=2010-07-01&rft.volume=6&rft.issue=7&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2010.493555 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-24 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2010.493555 ER - TY - JOUR T1 - Computational science in drug metabolism and toxicology. AN - 733374107; 20465524 AB - Computational scientific tools involving construction and testing of models, screening and data mining for drug and chemical induced toxicities and metabolism have significantly grown in experimental use to help guide product development and assist by enhancing certain areas of regulatory decision making. This themed issue of the journal entitled Computational Science in Drug Metabolism & Toxicology contains state-of-the-art review articles and perspectives covering a diversity of in silico approaches. Computational science tools have a strong potential for expediting our further understanding of drug metabolism and toxicity and are continually being developed and validated. The reader will gain an understanding of the current state of in silico tools and modeling approaches aimed at reducing these liabilities. In addition, how these tools are tested and developed for use in drug safety to support drug development efforts and a review of how they are used to predict genotoxic liabilities are covered in this issue. Computational science tools when properly validated and used judiciously can lend themselves as enablers to support drug safety assessment in investigative and applied settings. JF - Expert opinion on drug metabolism & toxicology AU - Valerio, Luis G AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Office of Pharmaceutical Science, White Oak 51 Room 4128, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Luis.Valerio@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 781 EP - 784 VL - 6 IS - 7 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Pharmaceutical Preparations -- metabolism KW - Toxicology -- trends KW - Computational Biology -- methods KW - Toxicology -- methods KW - Computational Biology -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733374107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Computational+science+in+drug+metabolism+and+toxicology.&rft.au=Valerio%2C+Luis+G&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-07-01&rft.volume=6&rft.issue=7&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2010.486789 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-02-24 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1517/17425255.2010.486789 ER - TY - JOUR T1 - Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. AN - 733352044; 20224926 AB - The potential for development of Parkinson's disease (PD)-like neurological dysfunction following occupational exposure to aerosolized welding fumes (WF) is an area of emerging concern. Welding consumables contain a complex mixture of metals, including iron (Fe) and manganese (Mn), which are known to be neurotoxic. To determine whether WF exposure poses a neurological risk particularly to the dopaminergic system, we treated Sprague-Dawley rats with WF particulates generated from two different welding processes, gas metal arc-mild steel (GMA-MS; low Mn, less water-soluble) and manual metal arc-hard surfacing (MMA-HS; high Mn, more water-soluble) welding. Following repeated intratracheal instillations (0.5 mg/rat, 1/week x 7 weeks) of GMA-MS or MMA-HS, elemental analysis and various molecular indices of neurotoxicity were measured at 1, 4, 35 or 105 days after last exposure. MMA-HS exposure, in particular, led to increased deposition of Mn in striatum and midbrain. Both fumes also caused loss of tyrosine hydroxylase (TH) protein in the striatum (~20%) and midbrain (~30%) by 1 day post-exposure. While the loss of TH following GMA-MS was transient, a sustained loss (34%) was observed in the midbrain 105 days after cessation of MMA-HS exposure. In addition, both fumes caused persistent down-regulation of dopamine D2 receptor (Drd2; 30-40%) and vesicular monoamine transporter 2 (Vmat2; 30-55%) mRNAs in the midbrain. WF exposure also modulated factors associated with synaptic transmission, oxidative stress, neuroinflammation and gliosis. Collectively, our findings demonstrate that repeated exposure to Mn-containing WF can cause persistent molecular alterations in dopaminergic targets. Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated. JF - Archives of toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Roberts, Jenny R AU - Chapman, Rebecca S AU - Chen, Bean T AU - Soukup, Joleen M AU - Ghio, Andrew J AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute For Occupational Safety and Health, Morgantown, WV 26505, USA. kos4@cdc.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 521 EP - 540 VL - 84 IS - 7 KW - Gases KW - 0 KW - Metals KW - Steel KW - 12597-69-2 KW - Manganese KW - 42Z2K6ZL8P KW - Iron KW - E1UOL152H7 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Occupational Exposure KW - Animals KW - Neurotoxicity Syndromes KW - Gases -- metabolism KW - Lung -- metabolism KW - Iron -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Steel -- toxicity KW - Down-Regulation KW - Parkinson Disease KW - Metals -- metabolism KW - Male KW - Metals -- toxicity KW - Manganese -- metabolism KW - Welding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733352044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Dopaminergic+neurotoxicity+following+pulmonary+exposure+to+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BRoberts%2C+Jenny+R%3BChapman%2C+Rebecca+S%3BChen%2C+Bean+T%3BSoukup%2C+Joleen+M%3BGhio%2C+Andrew+J%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2010-07-01&rft.volume=84&rft.issue=7&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-010-0525-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-10 N1 - Date created - 2010-06-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00204-010-0525-9 ER - TY - JOUR T1 - Exposure-response of posaconazole used for prophylaxis against invasive fungal infections: evaluating the need to adjust doses based on drug concentrations in plasma. AN - 733333163; 20505665 AB - The purpose of this article is to report the exposure-response (E-R) relationship of posaconazole oral suspension (POS) for prophylaxis against invasive fungal infections (IFIs), on the basis of the US Food and Drug Administration (FDA) clinical pharmacology review of two randomized, active-controlled clinical studies. Posaconazole average steady state plasma concentrations (C(avg)) ranged from 22 to 3,650 ng/ml after administration of POS 200 mg three times daily (t.i.d.). In a double-blind, randomized clinical trial, the quartile ranges of C(avg) with midpoint values of 289, 736, 1,239, and 2,607 ng/ml had clinical failure rates of 44, 21, 18, and 18%, respectively, indicating an inverse association between C(avg) and clinical failure rate. There were no significant relationships between C(avg) and posaconazole-related major adverse events. Determining posaconazole concentrations in plasma will aid in assessing the need for either POS dose adjustment (e.g., increasing the POS dose) or switching to another systemic antifungal drug, thereby improving the effectiveness of prophylaxis against IFIs. JF - Clinical pharmacology and therapeutics AU - Jang, S H AU - Colangelo, P M AU - Gobburu, J V S AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. seong.jang@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 115 EP - 119 VL - 88 IS - 1 KW - Antifungal Agents KW - 0 KW - Antineoplastic Agents KW - Triazoles KW - posaconazole KW - 6TK1G07BHZ KW - Abridged Index Medicus KW - Index Medicus KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Neutropenia -- complications KW - Treatment Outcome KW - Neutropenia -- chemically induced KW - Stem Cell Transplantation KW - Graft vs Host Disease -- complications KW - Antineoplastic Agents -- adverse effects KW - Antifungal Agents -- pharmacokinetics KW - Mycoses -- prevention & control KW - Antifungal Agents -- administration & dosage KW - Triazoles -- therapeutic use KW - Triazoles -- pharmacokinetics KW - Triazoles -- administration & dosage KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733333163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Exposure-response+of+posaconazole+used+for+prophylaxis+against+invasive+fungal+infections%3A+evaluating+the+need+to+adjust+doses+based+on+drug+concentrations+in+plasma.&rft.au=Jang%2C+S+H%3BColangelo%2C+P+M%3BGobburu%2C+J+V+S&rft.aulast=Jang&rft.aufirst=S&rft.date=2010-07-01&rft.volume=88&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2010.64 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-01 N1 - Date created - 2010-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Pharmacol Ther. 2011 Mar;89(3):351-2 [21270787] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/clpt.2010.64 ER - TY - JOUR T1 - No role for human papillomavirus in esophageal squamous cell carcinoma in China. AN - 733295015; 19918949 AB - Certain regions of China have high rates of esophageal squamous cell carcinoma (ESCC). Previous studies of human papillomavirus (HPV), a proposed causal factor, have produced highly variable results. We attempted to evaluate HPV and ESCC more definitively using extreme care to prevent DNA contamination. We collected tissue and serum in China from 272 histopathologically-confirmed ESCC cases with rigorous attention to good molecular biology technique. We tested for HPV DNA in fresh-frozen tumor tissue using PCR with PGMY L1 consensus primers and HPV16 and 18 type-specific E6 and E7 primers, and in formalin-fixed paraffin-embedded tumor tissue using SPF(10) L1 primers. In HPV-positive cases, we evaluated p16(INK4a) overexpression and HPV E6/E7 seropositivity as evidence of carcinogenic HPV activity. beta-globin, and thus DNA, was adequate in 98.2% of the frozen tumor tissues (267/272). Of these, 99.6% (95% confidence interval (CI) = 97.9-100.0%) were negative for HPV DNA by PGMY, and 100% (95% CI = 98.6-100%) were negative by HPV16/18 E6/E7 PCR. In the corresponding formalin-fixed paraffin-embedded tumor specimens, 99.3% (95% CI = 97.3-99.9%) were HPV negative by SPF(10). By PGMY, 1 case tested weakly positive for HPV89, a noncancer causing HPV type. By SPF(10), 2 cases tested weakly positive: 1 for HPV16 and 1 for HPV31. No HPV DNA-positive case had evidence of HPV oncogene activity as measured by p16(INK4a) overexpression or E6/E7 seropositivity. This study provides the most definitive evidence to date that HPV is not involved in ESCC carcinogenesis in China. HPV DNA contamination cannot be ruled out as an explanation for high HPV prevalence in ESCC tissue studies with less stringent tissue procurement and processing protocols. JF - International journal of cancer AU - Koshiol, Jill AU - Wei, Wen-Qiang AU - Kreimer, Aimee R AU - Chen, Wen AU - Gravitt, Patti AU - Ren, Jian-Song AU - Abnet, Christian C AU - Wang, Jian-Bing AU - Kamangar, Farin AU - Lin, Dong-Mei AU - von Knebel-Doeberitz, Magnus AU - Zhang, Yu AU - Viscidi, Raphael AU - Wang, Guo-Qing AU - Gillison, Maura L AU - Roth, Mark J AU - Dong, Zhi-Wei AU - Kim, Esther AU - Taylor, Philip R AU - Qiao, You-Lin AU - Dawsey, Sanford M AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852-7248, USA. koshiolj@mail.nih.gov Y1 - 2010/07/01/ PY - 2010 DA - 2010 Jul 01 SP - 93 EP - 100 VL - 127 IS - 1 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Humans KW - Aged KW - Middle Aged KW - DNA, Viral -- genetics KW - Male KW - Female KW - China KW - Papillomaviridae -- pathogenicity KW - Esophageal Neoplasms -- virology KW - Carcinoma, Squamous Cell -- pathology KW - Papillomaviridae -- genetics KW - Carcinoma, Squamous Cell -- virology KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733295015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=No+role+for+human+papillomavirus+in+esophageal+squamous+cell+carcinoma+in+China.&rft.au=Koshiol%2C+Jill%3BWei%2C+Wen-Qiang%3BKreimer%2C+Aimee+R%3BChen%2C+Wen%3BGravitt%2C+Patti%3BRen%2C+Jian-Song%3BAbnet%2C+Christian+C%3BWang%2C+Jian-Bing%3BKamangar%2C+Farin%3BLin%2C+Dong-Mei%3Bvon+Knebel-Doeberitz%2C+Magnus%3BZhang%2C+Yu%3BViscidi%2C+Raphael%3BWang%2C+Guo-Qing%3BGillison%2C+Maura+L%3BRoth%2C+Mark+J%3BDong%2C+Zhi-Wei%3BKim%2C+Esther%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin%3BDawsey%2C+Sanford+M&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2010-07-01&rft.volume=127&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.25023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-14 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 2004 Feb 15;189(4):686-98 [14767823] Am J Epidemiol. 2007 Jun 15;165(12):1424-33 [17420181] J Med Virol. 2004 Sep;74(1):107-16 [15258976] Am J Obstet Gynecol. 2004 Sep;191(3):757-61 [15467536] Obstet Gynecol. 1989 Dec;74(6):950-4 [2555753] Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):341-7 [8061584] Zhonghua Zhong Liu Za Zhi. 1995 Sep;17(5):321-4 [8697965] J Clin Microbiol. 1998 Feb;36(2):475-80 [9466762] Hum Pathol. 1998 Mar;29(3):266-71 [9496830] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] Am J Pathol. 1998 Dec;153(6):1741-8 [9846965] Int J Cancer. 1999 Apr 12;81(2):225-8 [10188723] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Int J Cancer. 2007 Aug 1;121(3):621-32 [17405118] Anticancer Res. 2008 Mar-Apr;28(2B):1133-8 [18505048] J Clin Microbiol. 2008 Oct;46(10):3437-45 [18716224] Cancer. 2008 Nov 15;113(10 Suppl):3036-46 [18980286] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008 Aug;22(4):251-3 [19105334] Lancet Oncol. 2009 Apr;10(4):321-2 [19350698] Cancer Causes Control. 2009 Nov;20(9):1705-13 [19705288] Sex Transm Infect. 1999 Oct;75(5):317-9 [10616355] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Scand J Gastroenterol. 2000 Feb;35(2):123-30 [10720108] J Natl Cancer Inst. 2000 Nov 1;92(21):1753-63 [11058618] Int J Cancer. 2001 Apr 15;92(2):276-84 [11291057] Carcinogenesis. 2001 Jun;22(6):929-34 [11375901] J Immunol Methods. 2001 Jul 1;253(1-2):153-62 [11384677] J Clin Pathol. 2002 Oct;55(10):721-8 [12354793] Int J Cancer. 2002 Nov 20;102(3):271-4 [12397650] Eur J Cancer. 2002 Nov;38(17):2229-42 [12441259] Int J Cancer. 2003 Feb 10;103(4):496-500 [12478665] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] J Natl Cancer Inst Monogr. 2003;(31):57-65 [12807947] J Natl Cancer Inst Monogr. 2003;(31):80-8 [12807950] Arch Pathol Lab Med. 2003 Aug;127(8):940-5 [12873165] J Natl Cancer Inst. 2003 Sep 17;95(18):1414-6 [13130117] Sex Transm Infect. 2003 Oct;79(5):426-7 [14573848] J Natl Cancer Inst. 2003 Dec 3;95(23):1772-83 [14652239] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] J Natl Cancer Inst. 2005 Feb 16;97(4):301-6 [15713965] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):467-75 [15734974] Int J Epidemiol. 2005 Apr;34(2):467-74 [15659476] Carcinogenesis. 2005 Jul;26(7):1280-4 [15774487] Int J Cancer. 2006 Aug 1;119(3):579-84 [16496409] Int J Cancer. 2006 Sep 15;119(6):1354-9 [16615110] N Engl J Med. 2007 May 10;356(19):1944-56 [17494927] J Clin Microbiol. 2004 Jul;42(7):3176-84 [15243079] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.25023 ER - TY - JOUR T1 - Early alterations in heart gene expression profiles associated with doxorubicin cardiotoxicity in rats. AN - 733148964; 19915844 AB - The antineoplastic anthracycline doxorubicin can induce a dose-dependent cardiomyopathy that limits the total cumulative dose prescribed to cancer patients. In both preclinical and clinical studies, pretreatment with dexrazoxane, an intracellular iron chelator, partially protects against anthracycline-induced cardiomyopathy. To identify potential additional cardioprotective treatment strategies, we investigated early doxorubicin-induced changes in cardiac gene expression. Spontaneously hypertensive male rats (n = 47) received weekly intravenous injections of doxorubicin (3 mg/kg) or saline 30 min after pretreatment with dexrazoxane (50 mg/kg) or saline by intraperitoneal injection. Cardiac samples were analyzed 24 h after the first (n = 20), second (n = 13), or third (n = 14) intravenous injection on days 1, 8, or 15 of the study, respectively. Rats receiving three doses of doxorubicin had minimal myocardial alterations that were attenuated by dexrazoxane. Cardiac expression levels of genes associated with the Nrf2-mediated stress response were increased after a single dose of doxorubicin, but not affected by cardioprotectant pretreatment. In contrast, an early repressive effect of doxorubicin on transcript levels of genes associated with mitochondrial function was attenuated by dexrazoxane pretreatment. Dexrazoxane had little effect on gene expression by itself. Genomic analysis provided further evidence that mitochondria are the primary target of doxorubicin-induced oxidative damage that leads to cardiomyopathy and the primary site of cardioprotective action by dexrazoxane. Additional strategies that prevent the formation of oxygen radicals by doxorubicin in mitochondria may provide increased cardioprotection. JF - Cancer chemotherapy and pharmacology AU - Thompson, Karol L AU - Rosenzweig, Barry A AU - Zhang, Jun AU - Knapton, Alan D AU - Honchel, Ronald AU - Lipshultz, Steven E AU - Retief, Jacques AU - Sistare, Frank D AU - Herman, Eugene H AD - Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. karol.thompson@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 303 EP - 314 VL - 66 IS - 2 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents KW - GA-Binding Protein Transcription Factor KW - Gabpb2 protein, rat KW - Troponin T KW - Razoxane KW - 5AR83PR647 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Rats, Inbred SHR KW - Troponin T -- metabolism KW - Troponin T -- blood KW - Oligonucleotide Array Sequence Analysis KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Reverse Transcriptase Polymerase Chain Reaction KW - Antineoplastic Combined Chemotherapy Protocols -- toxicity KW - Rats KW - Gene Expression Profiling KW - Razoxane -- pharmacology KW - GA-Binding Protein Transcription Factor -- genetics KW - GA-Binding Protein Transcription Factor -- biosynthesis KW - Mitochondria, Heart -- drug effects KW - Mitochondria, Heart -- metabolism KW - Antineoplastic Agents -- pharmacology KW - Male KW - Myocardium -- pathology KW - Heart Diseases -- chemically induced KW - Heart Diseases -- metabolism KW - Doxorubicin -- toxicity KW - Heart Diseases -- prevention & control KW - Myocardium -- metabolism KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733148964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Early+alterations+in+heart+gene+expression+profiles+associated+with+doxorubicin+cardiotoxicity+in+rats.&rft.au=Thompson%2C+Karol+L%3BRosenzweig%2C+Barry+A%3BZhang%2C+Jun%3BKnapton%2C+Alan+D%3BHonchel%2C+Ronald%3BLipshultz%2C+Steven+E%3BRetief%2C+Jacques%3BSistare%2C+Frank+D%3BHerman%2C+Eugene+H&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2010-07-01&rft.volume=66&rft.issue=2&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-009-1164-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-04 N1 - Date created - 2010-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00280-009-1164-9 ER - TY - JOUR T1 - Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde. AN - 733128641; 20347909 AB - This study examined the potential induction of tumor-associated mutations in formaldehyde-exposed rat nasal mucosa using a sensitive method, allele-specific competitive blocker-PCR (ACB-PCR). Levels of p53 codon 271 CGT to CAT and K-Ras codon 12 GGT to GAT mutations were quantified in nasal mucosa of rats exposed to formaldehyde. In addition, nasal mucosa cell proliferation was monitored because regenerative cell proliferation is considered a key event in formaldehyde-induced carcinogenesis. Male F344 rats (6-7 weeks old, 5 rats/group) were exposed to 0, 0.7, 2, 6, 10, and 15 ppm formaldehyde for 13 weeks (6 h/day, 5 days/week). ACB-PCR was used to determine levels of p53 and K-Ras mutations. Although two of five untreated rats had measureable spontaneous p53 mutant fractions (MFs), most nasal mucosa samples had p53 MFs below 10(-5). All K-Ras MF measurements were below 10(-5). No dose-related increases in p53 or K-Ras MF were observed, even though significant increases in bromodeoxyuridine incorporation demonstrated induced cell proliferation in the 10 and 15 ppm formaldehyde-treatment groups. Therefore, induction of tumor-associated p53 mutation likely occurs after several other key events in formaldehyde-induced carcinogenesis. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Meng, Fanxue AU - Bermudez, Edilberto AU - McKinzie, Page B AU - Andersen, Melvin E AU - Clewell, Harvey J AU - Parsons, Barbara L AD - US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA. Fanxue.Meng@fda.hhs.gov PY - 2010 SP - 274 EP - 283 VL - 57 IS - 2-3 KW - Codon KW - 0 KW - Tumor Suppressor Protein p53 KW - Formaldehyde KW - 1HG84L3525 KW - ras Proteins KW - EC 3.6.5.2 KW - Index Medicus KW - Rats KW - Cell Proliferation -- drug effects KW - ras Proteins -- genetics KW - Polymerase Chain Reaction KW - Animals KW - Rats, Inbred F344 KW - Codon -- genetics KW - Dose-Response Relationship, Drug KW - Tumor Suppressor Protein p53 -- genetics KW - Male KW - Nasal Mucosa -- pathology KW - Nose Neoplasms -- genetics KW - Nose Neoplasms -- pathology KW - Nose Neoplasms -- chemically induced KW - Nasal Mucosa -- metabolism KW - Nasal Mucosa -- drug effects KW - Mutation KW - Formaldehyde -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733128641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Measurement+of+tumor-associated+mutations+in+the+nasal+mucosa+of+rats+exposed+to+varying+doses+of+formaldehyde.&rft.au=Meng%2C+Fanxue%3BBermudez%2C+Edilberto%3BMcKinzie%2C+Page+B%3BAndersen%2C+Melvin+E%3BClewell%2C+Harvey+J%3BParsons%2C+Barbara+L&rft.aulast=Meng&rft.aufirst=Fanxue&rft.date=2010-07-01&rft.volume=57&rft.issue=2-3&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2010.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-16 N1 - Date created - 2010-06-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2010.03.007 ER - TY - JOUR T1 - Release liner removal method for transdermal drug delivery systems (TDDS) AN - 1399904759; 16705422 AB - A release liner removal test is a valuable test for assessing the quality of a transdermal drug delivery system (i.e., TDDS, patch). This test measures the force required to remove the release liner from a patch. The objective of the present study was to establish sample preparation and instrument parameters for measuring release liner removal adhesion for TDDS. Ten TDDS were evaluated (six drugs for a total of 29 lots). Patches which had a rate-controlling membrane were run as-is, since they could not be cut to a precise width without sacrificing their structural integrity. Patches that were square or rectangular in shape were run as-is, and the width of these patches was determined using a digital caliper. Patches which were not square or rectangular in shape and did not have a rate-controlling membrane were cut to a precise width using a specimen cutter. Double-sided tape was used to adhere the liner side of the transdermal system to a clean stainless steel test panel. A release liner peel adhesion method for TDDS is proposed using a dwell time of approximately 3min, a peel angle of 90?, and a peel speed of 300mm/min. ? 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:3177-3187, 2010 JF - Journal of Pharmaceutical Sciences AU - Wokovich, Anna M AU - Shen, Meiyu AU - Doub, William H AU - Machado, Stella G AU - Buhse, Lucinda F AD - Food and Drug Administration, Center for Drug Evaluation and Research, St. Louis, Missouri, anna.wokovich@fda.hhs.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 3177 EP - 3187 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 99 IS - 7 SN - 1520-6017, 1520-6017 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Drug development KW - stainless steel KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1399904759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Release+liner+removal+method+for+transdermal+drug+delivery+systems+%28TDDS%29&rft.au=Wokovich%2C+Anna+M%3BShen%2C+Meiyu%3BDoub%2C+William+H%3BMachado%2C+Stella+G%3BBuhse%2C+Lucinda+F&rft.aulast=Wokovich&rft.aufirst=Anna&rft.date=2010-07-01&rft.volume=99&rft.issue=7&rft.spage=3177&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=15206017&rft_id=info:doi/10.1002%2Fjps.22067 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jps.22067/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-07-01 N1 - Last updated - 2013-07-15 N1 - SubjectsTermNotLitGenreText - Drug delivery; Drug development; stainless steel DO - http://dx.doi.org/10.1002/jps.22067 ER - TY - JOUR T1 - Pathways Among Exposure to Violence, Maternal Depression, Family Structure, and Child Outcomes Through Parenting: A Multigroup Analysis AN - 1081870432; 201206388 AB - The present study examined the impact of proximal (maternal depression, family structure) and distal (exposure to violence) risk factors on parenting characteristics (warmth, control), which were in turn hypothesized to affect child social-emotional functioning. Using the Family and Child Experiences Study (FACES) 2000 cohort, findings revealed that study variables were significant predictors of child social-emotional functioning. Despite limited significant pathways in the structural equation models, the cumulative effect of the variables resulted in models accounting for 21%-37% of the outcome. Multigroup analysis revealed that although the amount of variance explained varied, the model held across subgroups. Findings support theories such as the family stress model that suggest that family risk factors negatively influencing children's development through influencing parenting behaviors. Findings also support considering both warmth and control as key parenting dimensions. It may be impractical for practitioners to address the myriad of potential risks encountered by low-income families, but parents can be equipped with mental health services, parent education, and other assistance to help them maintain positive parenting practices in the face of challenges. [Copyright American Psychological Association] JF - American Journal of Orthopsychiatry AU - Westbrook, T'Pring R AU - Harden, Brenda Jones Y1 - 2010/07// PY - 2010 DA - July 2010 SP - 386 EP - 400 PB - American Psychological Association, Washington DC VL - 80 IS - 3 SN - 0002-9432, 0002-9432 KW - parents KW - young children KW - Head Start KW - child adjustment KW - social skills KW - behavior problems KW - community violence KW - victimization KW - parent-child relations KW - family stress KW - depression KW - ethnicity KW - Depression (Psychology) KW - Risk Factors KW - Mothers KW - Family Structure KW - Child Development KW - Family Violence KW - Childrearing Practices KW - Parents KW - Children KW - article KW - 6121: therapeutic interventions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1081870432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Orthopsychiatry&rft.atitle=Pathways+Among+Exposure+to+Violence%2C+Maternal+Depression%2C+Family+Structure%2C+and+Child+Outcomes+Through+Parenting%3A+A+Multigroup+Analysis&rft.au=Westbrook%2C+T%27Pring+R%3BHarden%2C+Brenda+Jones&rft.aulast=Westbrook&rft.aufirst=T%27Pring&rft.date=2010-07-01&rft.volume=80&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Orthopsychiatry&rft.issn=00029432&rft_id=info:doi/10.1111%2Fj.1939-0025.2010.01042.x LA - English DB - Social Services Abstracts N1 - Date revised - 2012-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - AJORAG N1 - SubjectsTermNotLitGenreText - Childrearing Practices; Children; Parents; Family Violence; Child Development; Family Structure; Depression (Psychology); Mothers; Risk Factors DO - http://dx.doi.org/10.1111/j.1939-0025.2010.01042.x ER - TY - JOUR T1 - Association Between IL-1A Single Nucleotide Polymorphisms and Chronic Beryllium Disease and Beryllium Sensitization AN - 1028075962; 14690978 AB - Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1 A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1 super(Glu69) in additive, dominant, and recessive inheritance models. Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. Conclusions: These results indicate that genetic variations in the IL-1 A gene may play a role in the development of CBD but not BeS. JF - Journal of Occupational and Environmental Medicine AU - McCanlies, E C AU - Yucesoy, B AU - Mnatsakanova, A AU - Sloven, JE AU - Andrew, M AU - Frye, B L AU - Schuler, C R AU - Kreiss, K AU - Weston, A AD - NIOSH, CDC, MS-L4050, 1095 Willowdale Road, Morgantown, WV 26505, USA, eim4@cdc.gov PY - 2010 SP - 680 EP - 684 VL - 52 IS - 7 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Berylliosis KW - Histocompatibility antigen HLA KW - Heredity KW - Interleukin 2 KW - Interleukin 1 KW - Nuclease KW - Interleukin 9 KW - Single-nucleotide polymorphism KW - Beryllium KW - Regression analysis KW - Interleukin 1 receptors KW - Polymerase chain reaction KW - N 14810:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1028075962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Association+Between+IL-1A+Single+Nucleotide+Polymorphisms+and+Chronic+Beryllium+Disease+and+Beryllium+Sensitization&rft.au=McCanlies%2C+E+C%3BYucesoy%2C+B%3BMnatsakanova%2C+A%3BSloven%2C+JE%3BAndrew%2C+M%3BFrye%2C+B+L%3BSchuler%2C+C+R%3BKreiss%2C+K%3BWeston%2C+A&rft.aulast=McCanlies&rft.aufirst=E&rft.date=2010-07-01&rft.volume=52&rft.issue=7&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181e48ec8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-07-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Berylliosis; Interleukin 2; Heredity; Single-nucleotide polymorphism; Beryllium; Interleukin 1; Regression analysis; Polymerase chain reaction; Nuclease; Interleukin 1 receptors; Interleukin 9 DO - http://dx.doi.org/10.1097/JOM.0b013e3181e48ec8 ER - TY - JOUR T1 - Protecting Workers in Large-Scale Emergency Responses:NIOSH Experience in the Deepwater Horizon Response AN - 1020837063; 15498084 AB - On April 20, 2010, the Deepwater Horizon (DWH) semisubmersible Mobile Offshore Drilling Unit, located 45 miles southeast off the Louisiana coast, suffered a massive explosion and subsequent fire that ultimately led to the sinking of the Unit. Eleven workers lost their lives as a result of the explosion and fire, and seventeen other workers were injured. Oil from a subsea blowout began flowing into the Gulf of Mexico soon after the explosion, and continued to flow until the well was finally capped on July 15, 2010. JF - Journal of Occupational and Environmental Medicine AU - Kitt, M M AU - Decker, JA AU - Delaney, L AU - Funk, R AU - Halpin, J AU - Tepper, A AU - Spahr, J AU - Howard, J AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail Stop E-20, Atlanta, GA 30333, USA, mkitt@cdc.gov Y1 - 2010/07// PY - 2010 DA - Jul 2010 SP - 711 EP - 715 VL - 53 IS - 7 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Coastal zone KW - Emergency preparedness KW - Explosions KW - Fires KW - Oil KW - ASW, USA, Louisiana KW - ASW, Mexico Gulf KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1020837063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Protecting+Workers+in+Large-Scale+Emergency+Responses%3ANIOSH+Experience+in+the+Deepwater+Horizon+Response&rft.au=Kitt%2C+M+M%3BDecker%2C+JA%3BDelaney%2C+L%3BFunk%2C+R%3BHalpin%2C+J%3BTepper%2C+A%3BSpahr%2C+J%3BHoward%2C+J&rft.aulast=Kitt&rft.aufirst=M&rft.date=2010-07-01&rft.volume=53&rft.issue=7&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e31822543b6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-06-01 N1 - Last updated - 2012-06-18 N1 - SubjectsTermNotLitGenreText - Oil; Fires; Coastal zone; Emergency preparedness; Explosions; ASW, Mexico Gulf; ASW, USA, Louisiana DO - http://dx.doi.org/10.1097/JOM.0b013e31822543b6 ER - TY - CPAPER T1 - Equity in the Finance and Delivery of Healthcare in the United States T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839635318; 5889032 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Selden, Thomas Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - USA KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839635318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Equity+in+the+Finance+and+Delivery+of+Healthcare+in+the+United+States&rft.au=Selden%2C+Thomas&rft.aulast=Selden&rft.aufirst=Thomas&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Got Meaningful Use? Implementing Programs and Policies to Achieve Widespread Use of Health Information Technology T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839635156; 5888815 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Harris, Yael Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Information technology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839635156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Got+Meaningful+Use%3F+Implementing+Programs+and+Policies+to+Achieve+Widespread+Use+of+Health+Information+Technology&rft.au=Harris%2C+Yael&rft.aulast=Harris&rft.aufirst=Yael&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Literature Review and Evidence Synthesis T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634558; 5888956 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Chang, Stephanie AU - Jonas, Dan AU - McPheeters, Melissa AU - White, C Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Literature+Review+and+Evidence+Synthesis&rft.au=Chang%2C+Stephanie%3BJonas%2C+Dan%3BMcPheeters%2C+Melissa%3BWhite%2C+C&rft.aulast=Chang&rft.aufirst=Stephanie&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Talking the Talk: Best Practices in Effectively Communicating Research Results T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839634511; 5888918 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Brach, Cindy AU - Mason, Diana Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Best practices KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839634511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Talking+the+Talk%3A+Best+Practices+in+Effectively+Communicating+Research+Results&rft.au=Brach%2C+Cindy%3BMason%2C+Diana&rft.aulast=Brach&rft.aufirst=Cindy&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=2625&navIte LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Demystifying the Federal Grant Review Process: Focusing on Comparative Effectiveness Research T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839633018; 5888917 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Chesley, Francis AU - Ming, Tai-Seale Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Grants KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839633018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Demystifying+the+Federal+Grant+Review+Process%3A+Focusing+on+Comparative+Effectiveness+Research&rft.au=Chesley%2C+Francis%3BMing%2C+Tai-Seale&rft.aulast=Chesley&rft.aufirst=Francis&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Gender Differences in the Burden of Out-of-Pocket Health Care Expenditures T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632933; 5888858 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Taylor, Amy Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Sex KW - Health care KW - Sex differences KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Gender+Differences+in+the+Burden+of+Out-of-Pocket+Health+Care+Expenditures&rft.au=Taylor%2C+Amy&rft.aulast=Taylor&rft.aufirst=Amy&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Trends in Preventable Hospitalization Patterns among the Adults: A Small Area Analysis of U.S. States T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632920; 5888838 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Basu, Jayasree Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - USA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=Trends+in+Preventable+Hospitalization+Patterns+among+the+Adults%3A+A+Small+Area+Analysis+of+U.S.+States&rft.au=Basu%2C+Jayasree&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - New Frontiers in Health Workforce Research: Rethinking the Data Infrastructure T2 - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AN - 839632617; 5888870 JF - 2010 AcademyHealth's Annual Research Meeting (ARM 2010) AU - Straw, Roger AU - Kronick, Richard AU - Moore, Jean AU - Salsburg, Edward AU - Skillman, Susan Y1 - 2010/06/27/ PY - 2010 DA - 2010 Jun 27 KW - {Q1} KW - Infrastructure KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.atitle=New+Frontiers+in+Health+Workforce+Research%3A+Rethinking+the+Data+Infrastructure&rft.au=Straw%2C+Roger%3BKronick%2C+Richard%3BMoore%2C+Jean%3BSalsburg%2C+Edward%3BSkillman%2C+Susan&rft.aulast=Straw&rft.aufirst=Roger&rft.date=2010-06-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+AcademyHealth%27s+Annual+Research+Meeting+%28ARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.academyhealth.org/Events/content.cfm?ItemNumber=857&navItem LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Pulmonary Vascular Resistance Index (PVRI) Is a Significant and Consistent Predictor of Exercise Capacity (6MWD) in Pulmonary Arterial Hypertension (PAH) Trials T2 - 9th International Pulmonary Hypertension Conference and Scientific Sessions AN - 839663128; 5912474 JF - 9th International Pulmonary Hypertension Conference and Scientific Sessions AU - Brar, S AU - Madabushi, R AU - Stockbridge, N AU - Gobburu, J AU - Jadhav, P Y1 - 2010/06/25/ PY - 2010 DA - 2010 Jun 25 KW - {Q1} KW - Hypertension KW - Lung KW - Physical training KW - Aromatic hydrocarbons KW - Circulatory system KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839663128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Pulmonary+Hypertension+Conference+and+Scientific+Sessions&rft.atitle=Pulmonary+Vascular+Resistance+Index+%28PVRI%29+Is+a+Significant+and+Consistent+Predictor+of+Exercise+Capacity+%286MWD%29+in+Pulmonary+Arterial+Hypertension+%28PAH%29+Trials&rft.au=Brar%2C+S%3BMadabushi%2C+R%3BStockbridge%2C+N%3BGobburu%2C+J%3BJadhav%2C+P&rft.aulast=Brar&rft.aufirst=S&rft.date=2010-06-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Pulmonary+Hypertension+Conference+and+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.phaonlineuniv.org/sites/default/files/presentations/2010_Sc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. AN - 733371686; 20481456 AB - Graphitic nanomaterials such as graphene layers (G) and single-wall carbon nanotubes (SWCNT) are potential candidates in a large number of biomedical applications. However, little is known about the effects of these nanomaterials on biological systems. Here we show that the shape of these materials is directly related to their induced cellular toxicity. Both G and SWCNT induce cytotoxic effects, and these effects are concentration- and shape-dependent. Interestingly, at low concentrations, G induced stronger metabolic activity than SWCNT, a trend that reversed at higher concentrations. Lactate dehydrogenase levels were found to be significantly higher for SWCNT as compared to the G samples. Moreover, reactive oxygen species were generated in a concentration- and time-dependent manner after exposure to G, indicating an oxidative stress mechanism. Furthermore, time-dependent caspase 3 activation after exposure to G (10 microg/mL) shows evidence of apoptosis. Altogether these studies suggest different biological activities of the graphitic nanomaterials, with the shape playing a primary role. JF - ACS nano AU - Zhang, Yongbin AU - Ali, Syed F AU - Dervishi, Enkeleda AU - Xu, Yang AU - Li, Zhongrui AU - Casciano, Daniel AU - Biris, Alexandru S AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. Y1 - 2010/06/22/ PY - 2010 DA - 2010 Jun 22 SP - 3181 EP - 3186 VL - 4 IS - 6 KW - Nanotubes, Carbon KW - 0 KW - Graphite KW - 7782-42-5 KW - Index Medicus KW - Rats KW - Animals KW - Particle Size KW - Materials Testing KW - PC12 Cells KW - Nanotubes, Carbon -- chemistry KW - Cell Survival -- drug effects KW - Graphite -- toxicity KW - Nanotubes, Carbon -- ultrastructure KW - Apoptosis -- drug effects KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733371686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+nano&rft.atitle=Cytotoxicity+effects+of+graphene+and+single-wall+carbon+nanotubes+in+neural+phaeochromocytoma-derived+PC12+cells.&rft.au=Zhang%2C+Yongbin%3BAli%2C+Syed+F%3BDervishi%2C+Enkeleda%3BXu%2C+Yang%3BLi%2C+Zhongrui%3BCasciano%2C+Daniel%3BBiris%2C+Alexandru+S&rft.aulast=Zhang&rft.aufirst=Yongbin&rft.date=2010-06-22&rft.volume=4&rft.issue=6&rft.spage=3181&rft.isbn=&rft.btitle=&rft.title=ACS+nano&rft.issn=1936-086X&rft_id=info:doi/10.1021%2Fnn1007176 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-10-08 N1 - Date created - 2010-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/nn1007176 ER - TY - CPAPER T1 - Nanotechnology EHS Overview T2 - 2010 Symposium on Environment, Health & Safety AN - 839698997; 5927148 JF - 2010 Symposium on Environment, Health & Safety AU - Geraci, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839698997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Nanotechnology+EHS+Overview&rft.au=Geraci%2C+C&rft.aulast=Geraci&rft.aufirst=C&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Lessons learned from the field, how to protect yourself from occupational exposure to engineered nanomaterials T2 - 2010 Symposium on Environment, Health & Safety AN - 839696954; 5927164 JF - 2010 Symposium on Environment, Health & Safety AU - Hodson, L AU - Geraci, C AU - Methner, M AU - Crawford, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Occupational exposure KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839696954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Lessons+learned+from+the+field%2C+how+to+protect+yourself+from+occupational+exposure+to+engineered+nanomaterials&rft.au=Hodson%2C+L%3BGeraci%2C+C%3BMethner%2C+M%3BCrawford%2C+C&rft.aulast=Hodson&rft.aufirst=L&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Ultra-Structural Analysis of the Interaction of Carboxylated Multi-Walled Carbon Nanotubes with Human Blood Platelets T2 - 2010 Symposium on Environment, Health & Safety AN - 839695521; 5927155 JF - 2010 Symposium on Environment, Health & Safety AU - Lacerda, S AU - Semberova, J AU - Holada, K AU - Simakova, O AU - Gelderman-Fuhrmann, M AU - Simak, J Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - Blood KW - Carbon KW - Platelets KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839695521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Ultra-Structural+Analysis+of+the+Interaction+of+Carboxylated+Multi-Walled+Carbon+Nanotubes+with+Human+Blood+Platelets&rft.au=Lacerda%2C+S%3BSemberova%2C+J%3BHolada%2C+K%3BSimakova%2C+O%3BGelderman-Fuhrmann%2C+M%3BSimak%2C+J&rft.aulast=Lacerda&rft.aufirst=S&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Applying Basic Risk Management Principles to Nanomaterial Processes T2 - 2010 Symposium on Environment, Health & Safety AN - 839695430; 5927162 JF - 2010 Symposium on Environment, Health & Safety AU - Geraci, C Y1 - 2010/06/21/ PY - 2010 DA - 2010 Jun 21 KW - {Q1} KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839695430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.atitle=Applying+Basic+Risk+Management+Principles+to+Nanomaterial+Processes&rft.au=Geraci%2C+C&rft.aulast=Geraci&rft.aufirst=C&rft.date=2010-06-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Symposium+on+Environment%2C+Health+%26+Safety&rft.issn=&rft_id=info:doi/ L2 - http://www.techconnectworld.com/Nanotech2010/symposia/Environment_Soci LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Increasing Tractor Operator Protection through NIOSH Crops Research T2 - 2010 Annual International Meeting of American Society of Agricultural and Biological Engineers AN - 839699139; 5945675 JF - 2010 Annual International Meeting of American Society of Agricultural and Biological Engineers AU - McKenzie Jr, Eugene AU - Harris, J R Y1 - 2010/06/20/ PY - 2010 DA - 2010 Jun 20 KW - {Q1} KW - Agricultural equipment KW - Crops KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839699139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+International+Meeting+of+American+Society+of+Agricultural+and+Biological+Engineers&rft.atitle=Increasing+Tractor+Operator+Protection+through+NIOSH+Crops+Research&rft.au=McKenzie+Jr%2C+Eugene%3BHarris%2C+J+R&rft.aulast=McKenzie+Jr&rft.aufirst=Eugene&rft.date=2010-06-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+International+Meeting+of+American+Society+of+Agricultural+and+Biological+Engineers&rft.issn=&rft_id=info:doi/ L2 - http://www.asabemeetings.org/10AIM-Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantitation of Steviol Glycosides from Stevia Species by High-Performance Liquid Chromatography T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839601161; 5882312 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Jaworska, Karolina AU - Delmonte, Pierluigi AU - Cacciola, Francesco AU - Hartwig, Andrea AU - Rader, Jeanne Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Liquid chromatography KW - Steviol glycosides KW - High-performance liquid chromatography KW - Quantitation KW - Glycosides KW - {Q2} KW - Stevia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839601161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Quantitation+of+Steviol+Glycosides+from+Stevia+Species+by+High-Performance+Liquid+Chromatography&rft.au=Jaworska%2C+Karolina%3BDelmonte%2C+Pierluigi%3BCacciola%2C+Francesco%3BHartwig%2C+Andrea%3BRader%2C+Jeanne&rft.aulast=Jaworska&rft.aufirst=Karolina&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development and Validation of LC/MS/MS for 10 Phthalate Metabolites in Human Urine T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839598367; 5882388 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Hong, Soon AU - Nam, Hye AU - Kang, Il AU - Kim, Tae AU - Cho, Sang AU - Jung, Su AU - Lee, Jang AU - Kim, Jun AU - Kang, Tae AU - Lee, Kwang AU - Yoon, Hae Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Phthalates KW - Metabolites KW - Urine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839598367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Development+and+Validation+of+LC%2FMS%2FMS+for+10+Phthalate+Metabolites+in+Human+Urine&rft.au=Hong%2C+Soon%3BNam%2C+Hye%3BKang%2C+Il%3BKim%2C+Tae%3BCho%2C+Sang%3BJung%2C+Su%3BLee%2C+Jang%3BKim%2C+Jun%3BKang%2C+Tae%3BLee%2C+Kwang%3BYoon%2C+Hae&rft.aulast=Hong&rft.aufirst=Soon&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Employment of an Ortogonal Normal Phase x Reversed Phase System for the Characterization of Stevia Rebaudiana T2 - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AN - 839593714; 5882443 JF - 35th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2010) AU - Cacciola, Francesco AU - Delmonte, Pierluigi AU - Jaworska, Karolina AU - Mondello, Luigi AU - Rader, Jeanne Y1 - 2010/06/19/ PY - 2010 DA - 2010 Jun 19 KW - {Q1} KW - Employment KW - {Q2} KW - Stevia rebaudiana KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839593714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.atitle=Employment+of+an+Ortogonal+Normal+Phase+x+Reversed+Phase+System+for+the+Characterization+of+Stevia+Rebaudiana&rft.au=Cacciola%2C+Francesco%3BDelmonte%2C+Pierluigi%3BJaworska%2C+Karolina%3BMondello%2C+Luigi%3BRader%2C+Jeanne&rft.aulast=Cacciola&rft.aufirst=Francesco&rft.date=2010-06-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+International+Symposium+on+High+Performance+Liquid+Phase+Separations+and+Related+Techniques+%28HPLC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/HPLC%202010%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - JOUR T1 - Molecular targets of epigenetic regulation and effectors of environmental influences AN - 762265106; 13200085 AB - The true understanding of what we currently define as epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression increased. The current explosion of research on epigenetics and the increasing documentation of the effects of various environmental factors on DNA methylation, chromatin modification, as well as on the expression of small non-coding RNAs (ncRNAs) have expanded the scope of research on the etiology of various diseases including cancer. The current review briefly discusses the molecular mechanisms of epigenetic regulation and expands the discussion with examples on the role of environment, such as the immediate environment during development, in inducing epigenetic changes and modulating gene expression. JF - Toxicology and Applied Pharmacology AU - Choudhuri, Supratim AU - Cui, Yue AU - Klaassen, Curtis D AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Biotechnology and GRAS Notice Review, College Park, MD, USA Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 378 EP - 393 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 245 IS - 3 SN - 0041-008X, 0041-008X KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts; Toxicology Abstracts KW - Cancer KW - epigenetics KW - DNA KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762265106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Molecular+targets+of+epigenetic+regulation+and+effectors+of+environmental+influences&rft.au=Choudhuri%2C+Supratim%3BCui%2C+Yue%3BKlaassen%2C+Curtis+D&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2010-06-15&rft.volume=245&rft.issue=3&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2010.03.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - epigenetics; DNA DO - http://dx.doi.org/10.1016/j.taap.2010.03.022 ER - TY - JOUR T1 - PERFLUOROOCTANE SULFONATE (PFOS) INDUCES REACTIVE OXYGEN SPECIES (ROS) PRODUCTION IN HUMAN MICROVASCULAR ENDOTHELIAL CELLS: ROLE IN ENDOTHELIAL PERMEABILITY AN - 746079379; 12920220 AB - Perfluorooctane sulfonate (PFOS) is a member of the perfluoroalkyl acids (PFAA) containing an eight-carbon backbone. PFOS is a man-made chemical with carbon-fluorine bonds that are among the strongest in organic chemistry, and PFOS is widely used in industry. Human occupational and environmental exposure to PFOS occurs globally. PFOS is non-biodegradable and is persistent in the human body and environment In this study, data demonstrated that exposure of human microvascular endothelial cells (HMVEC) to PFOS induced the production of reactive oxygen species (ROS) at both high and low concentrations. Morphologically, it was found that exposure to PFOS induced actin filament remodeling and endothelial permeability changes in HMVEC. Furthermore, data demonstrated that the production of ROS plays a regulatory role in PFOS-induced actin filament remodeling and the increase in endothelial permeability. Our results indicate that the generation of ROS may play a role in PFOS-induced aberrations of the endothelial permeability barrier. The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Qian, Yong AU - Ducatman, Alan AU - Ward, Rebecca AU - Leonard, Steve AU - Bukowsld, Valerie AU - Guo, Nancy Lan AU - Shi, Xianglin AU - Vallyathan, Val AU - Castranova, Vincent AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 819 EP - 836 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 73 IS - 7-12 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Microvasculature KW - sulfonates KW - Data processing KW - Endothelial cells KW - Oxygen KW - Permeability KW - Reactive oxygen species KW - Acids KW - Actin KW - Filaments KW - Side effects KW - Occupational exposure KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746079379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=PERFLUOROOCTANE+SULFONATE+%28PFOS%29+INDUCES+REACTIVE+OXYGEN+SPECIES+%28ROS%29+PRODUCTION+IN+HUMAN+MICROVASCULAR+ENDOTHELIAL+CELLS%3A+ROLE+IN+ENDOTHELIAL+PERMEABILITY&rft.au=Qian%2C+Yong%3BDucatman%2C+Alan%3BWard%2C+Rebecca%3BLeonard%2C+Steve%3BBukowsld%2C+Valerie%3BGuo%2C+Nancy+Lan%3BShi%2C+Xianglin%3BVallyathan%2C+Val%3BCastranova%2C+Vincent&rft.aulast=Qian&rft.aufirst=Yong&rft.date=2010-06-15&rft.volume=73&rft.issue=7-12&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287391003689317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Microvasculature; Permeability; Data processing; Reactive oxygen species; Acids; Actin; Filaments; Occupational exposure; Side effects; Oxygen; sulfonates DO - http://dx.doi.org/10.1080/15287391003689317 ER - TY - JOUR T1 - Prospective study of body mass index, physical activity and thyroid cancer AN - 745719154; 13163634 AB - Increased body size and physical inactivity are positively related to risk of several cancers, but only few epidemiologic studies have investigated body-mass index (BMI) and physical activity in relation to thyroid cancer. We examined the relations of BMI and physical activity to thyroid cancer in a prospective cohort of 484,326 United States men and women, followed from 1995/1996 to 2003. During 3,490,300 person-years of follow-up, we documented 352 newly incident cases of thyroid cancer. The multivariate relative risks (RR) of thyroid cancer for BMI values of 18.5-24.9 (reference), 25.0-29.9 and 30 kg m-2 were 1.0, 1.27 and 1.39 [95% confidence interval (CI) = 1.05-1.85]. Adiposity predicted papillary thyroid cancers (RR comparing extreme BMI categories = 1.47; 95% CI = 1.03-2.10) and, based on small numbers, suggestively predicted follicular thyroid cancers (RR = 1.49; 95% CI = 0.79-2.82) and anaplastic thyroid cancers (RR = 5.80; 95% CI = 0.99-34.19). No relation with BMI was noted for medullary thyroid cancers (RR = 0.97; 95% CI = 0.27-3.43). The positive relation of BMI to total thyroid cancer was evident for men but not for women. However, the test of interaction (p = 0.463) indicated no statistically significant gender difference. Physical activity was unassociated with thyroid cancer. The RRs of total thyroid cancer for low (reference), intermediate, and high level of physical activity were 1.0, 1.01 and 1.01 (95% CI = 0.76-1.34, p for trend = 0.931), respectively. Our results support an adverse effect of adiposity on risk for developing total and papillary, and possibly follicular thyroid cancers. Based on only 15 cases, adiposity was unrelated to medullary thyroid cancers. Physical activity was unrelated to total thyroid cancer. JF - International Journal of Cancer AU - Leitzmann, Michael F AU - Brenner, Alina AU - Moore, Steven C AU - Koebnick, Corinna AU - Park, Yikyung AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Ron, Elaine AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, michael.leitzmann@klinik.uni-regensburg.de Y1 - 2010/06/15/ PY - 2010 DA - 2010 Jun 15 SP - 2947 EP - 2956 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 12 SN - 0020-7136, 0020-7136 KW - Physical Education Index; Risk Abstracts KW - Statistics KW - Men KW - Body mass KW - Women KW - Thyroid KW - body size KW - Exercise KW - Sex differences KW - Cancer KW - Anthropometry KW - USA KW - body mass KW - Gender KW - physical activity KW - Trends KW - Side effects KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Prospective+study+of+body+mass+index%2C+physical+activity+and+thyroid+cancer&rft.au=Leitzmann%2C+Michael+F%3BBrenner%2C+Alina%3BMoore%2C+Steven+C%3BKoebnick%2C+Corinna%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BRon%2C+Elaine&rft.aulast=Leitzmann&rft.aufirst=Michael&rft.date=2010-06-15&rft.volume=126&rft.issue=12&rft.spage=2947&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24913 L2 - http://www3.interscience.wiley.com/journal/122613798/abstract LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Anthropometry; Statistics; Men; Body mass; Women; Exercise; Trends; Sex differences; Cancer; body mass; Gender; Thyroid; body size; physical activity; Side effects; USA DO - http://dx.doi.org/10.1002/ijc.24913 ER - TY - CPAPER T1 - ICH Quality Implementation Working Group Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754290953; 5829059 JF - 46th Annual Meeting of the Drug Information Association AU - Morefield, Elaine Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754290953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=ICH+Quality+Implementation+Working+Group+Update&rft.au=Morefield%2C+Elaine&rft.aulast=Morefield&rft.aufirst=Elaine&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enforcement Update from Ddmac T2 - 46th Annual Meeting of the Drug Information Association AN - 754289003; 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5829441 JF - 46th Annual Meeting of the Drug Information Association AU - Toigo, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754284094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Involving+Patients%3A+An+FDA+Perspective&rft.au=Toigo%2C+Theresa&rft.aulast=Toigo&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US GLP Regulations Facing Globalization Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754283849; 5829371 JF - 46th Annual Meeting of the Drug Information Association AU - Yao, Dalin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Globalization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+GLP+Regulations+Facing+Globalization+Challenges&rft.au=Yao%2C+Dalin&rft.aulast=Yao&rft.aufirst=Dalin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Authoring to Help Fda'S Review T2 - 46th Annual Meeting of the Drug Information Association AN - 754283799; 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5829040 JF - 46th Annual Meeting of the Drug Information Association AU - Sanhai, Wendy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754283225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Perspective+from+the+FDA&rft.au=Sanhai%2C+Wendy&rft.aulast=Sanhai&rft.aufirst=Wendy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Novel Adjuvants: Need for New Preclinical Assays to Evaluate Safety T2 - 46th Annual Meeting of the Drug Information Association AN - 754282868; 5829535 JF - 46th Annual Meeting of the Drug Information Association AU - Golding, Hana Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Adjuvants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Novel+Adjuvants%3A+Need+for+New+Preclinical+Assays+to+Evaluate+Safety&rft.au=Golding%2C+Hana&rft.aulast=Golding&rft.aufirst=Hana&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Randomization in Clinical Trials: A Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754282703; 5829472 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H M Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Randomization+in+Clinical+Trials%3A+A+Regulatory+Perspective&rft.au=Hung%2C+H+M&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Quality-by-design: Challenges and Opportunities T2 - 46th Annual Meeting of the Drug Information Association AN - 754282638; 5829254 JF - 46th Annual Meeting of the Drug Information Association AU - Woodcock, Janet Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Quality-by-design%3A+Challenges+and+Opportunities&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Compliance Considerations When Outsourcing in a Clinical Trial T2 - 46th Annual Meeting of the Drug Information Association AN - 754282086; 5828808 JF - 46th Annual Meeting of the Drug Information Association AU - Lewin, Constance Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - Clinical trials KW - Outsourcing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754282086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Regulatory+Compliance+Considerations+When+Outsourcing+in+a+Clinical+Trial&rft.au=Lewin%2C+Constance&rft.aulast=Lewin&rft.aufirst=Constance&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug Information and the Patient Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754281432; 5829440 JF - 46th Annual Meeting of the Drug Information Association AU - Smith, Nancy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug+Information+and+the+Patient+Perspective&rft.au=Smith%2C+Nancy&rft.aulast=Smith&rft.aufirst=Nancy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Key Components of the DSUR: Part 2 - Regulatory Authority Expectations and Implementation in the US T2 - 46th Annual Meeting of the Drug Information Association AN - 754281354; 5829423 JF - 46th Annual Meeting of the Drug Information Association AU - Unger, Ellis Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Key+Components+of+the+DSUR%3A+Part+2+-+Regulatory+Authority+Expectations+and+Implementation+in+the+US&rft.au=Unger%2C+Ellis&rft.aulast=Unger&rft.aufirst=Ellis&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug-device Combination Products: Quality Considerations from an FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754281281; 5829407 JF - 46th Annual Meeting of the Drug Information Association AU - Srinivasachar, Kasturi Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug-device+Combination+Products%3A+Quality+Considerations+from+an+FDA+Perspective&rft.au=Srinivasachar%2C+Kasturi&rft.aulast=Srinivasachar&rft.aufirst=Kasturi&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Electronic Registration and Listing: New Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754281141; 5829354 JF - 46th Annual Meeting of the Drug Information Association AU - Mazyck, David Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Electronic+Registration+and+Listing%3A+New+Challenges&rft.au=Mazyck%2C+David&rft.aulast=Mazyck&rft.aufirst=David&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Implementing Qbd in Fda'S Gmp Program T2 - 46th Annual Meeting of the Drug Information Association AN - 754281018; 5829187 JF - 46th Annual Meeting of the Drug Information Association AU - Shah, Vibhakar Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Implementing+Qbd+in+Fda%27S+Gmp+Program&rft.au=Shah%2C+Vibhakar&rft.aulast=Shah&rft.aufirst=Vibhakar&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Transition to Edrls: Highlights and Lessons Learned T2 - 46th Annual Meeting of the Drug Information Association AN - 754279856; 5829355 JF - 46th Annual Meeting of the Drug Information Association AU - Rahjou-Esfandiary, Leyla Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754279856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Transition+to+Edrls%3A+Highlights+and+Lessons+Learned&rft.au=Rahjou-Esfandiary%2C+Leyla&rft.aulast=Rahjou-Esfandiary&rft.aufirst=Leyla&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Agency Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754278852; 5828910 JF - 46th Annual Meeting of the Drug Information Association AU - Wilson, Stephen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=An+Agency+Perspective&rft.au=Wilson%2C+Stephen&rft.aulast=Wilson&rft.aufirst=Stephen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Advisory Committees: Regulatory Policy Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754278738; 5828881 JF - 46th Annual Meeting of the Drug Information Association AU - Warner, Jill Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advisory committees KW - FDA KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Advisory+Committees%3A+Regulatory+Policy+Update&rft.au=Warner%2C+Jill&rft.aulast=Warner&rft.aufirst=Jill&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Primer on Advertising and Promotion T2 - 46th Annual Meeting of the Drug Information Association AN - 754278646; 5828858 JF - 46th Annual Meeting of the Drug Information Association AU - Davis, Kristin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advertising KW - Primers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754278646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Primer+on+Advertising+and+Promotion&rft.au=Davis%2C+Kristin&rft.aulast=Davis&rft.aufirst=Kristin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US Regulatory Trends in GCP Compliance T2 - 46th Annual Meeting of the Drug Information Association AN - 754277516; 5829553 JF - 46th Annual Meeting of the Drug Information Association AU - Purohit-Sheth, Tejashri Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+Regulatory+Trends+in+GCP+Compliance&rft.au=Purohit-Sheth%2C+Tejashri&rft.aulast=Purohit-Sheth&rft.aufirst=Tejashri&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Collaborative Development of Analytical Tools: Streamlining Analysis of Clinical Trial Data T2 - 46th Annual Meeting of the Drug Information Association AN - 754277434; 5829570 JF - 46th Annual Meeting of the Drug Information Association AU - Soukup, Mat Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Collaborative+Development+of+Analytical+Tools%3A+Streamlining+Analysis+of+Clinical+Trial+Data&rft.au=Soukup%2C+Mat&rft.aulast=Soukup&rft.aufirst=Mat&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Reflecting on ADaM from a Reviewer's Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754277145; 5829527 JF - 46th Annual Meeting of the Drug Information Association AU - Mele, Joy Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754277145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Reflecting+on+ADaM+from+a+Reviewer%27s+Perspective&rft.au=Mele%2C+Joy&rft.aulast=Mele&rft.aufirst=Joy&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Overview of Marketed Unapproved Drugs: Safety and Effi cacy Issues, Compliance Policy Guide, and Enforcement Actions T2 - 46th Annual Meeting of the Drug Information Association AN - 754276665; 5829465 JF - 46th Annual Meeting of the Drug Information Association AU - Mehta, Rikin Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Compliance KW - Drugs KW - Reviews KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Overview+of+Marketed+Unapproved+Drugs%3A+Safety+and+Effi+cacy+Issues%2C+Compliance+Policy+Guide%2C+and+Enforcement+Actions&rft.au=Mehta%2C+Rikin&rft.aulast=Mehta&rft.aufirst=Rikin&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Path from Scoping to Integrated Review for Genomic Data T2 - 46th Annual Meeting of the Drug Information Association AN - 754276635; 5829461 JF - 46th Annual Meeting of the Drug Information Association AU - Pacanowski, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Reviews KW - Data processing KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Path+from+Scoping+to+Integrated+Review+for+Genomic+Data&rft.au=Pacanowski%2C+Michael&rft.aulast=Pacanowski&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Impact of New Comparative Eff ective Requirements T2 - 46th Annual Meeting of the Drug Information Association AN - 754276601; 5829157 JF - 46th Annual Meeting of the Drug Information Association AU - Woodcock, Janet Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Impact+of+New+Comparative+Eff+ective+Requirements&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pharmacogenetics, Regulatory Science, and the Advancement of Personalized Health T2 - 46th Annual Meeting of the Drug Information Association AN - 754276586; 5829460 JF - 46th Annual Meeting of the Drug Information Association AU - Zineh, Issam Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Pharmacogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Pharmacogenetics%2C+Regulatory+Science%2C+and+the+Advancement+of+Personalized+Health&rft.au=Zineh%2C+Issam&rft.aulast=Zineh&rft.aufirst=Issam&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Fda'S Clinical Reviewer'S Perspective on Csr Safety Narratives T2 - 46th Annual Meeting of the Drug Information Association AN - 754276354; 5829215 JF - 46th Annual Meeting of the Drug Information Association AU - Chazin, Howard Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Fda%27S+Clinical+Reviewer%27S+Perspective+on+Csr+Safety+Narratives&rft.au=Chazin%2C+Howard&rft.aulast=Chazin&rft.aufirst=Howard&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Special Considerations in Life Science Criminal Investigations T2 - 46th Annual Meeting of the Drug Information Association AN - 754276310; 5829211 JF - 46th Annual Meeting of the Drug Information Association AU - Watson, Glenn Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Special+Considerations+in+Life+Science+Criminal+Investigations&rft.au=Watson%2C+Glenn&rft.aulast=Watson&rft.aufirst=Glenn&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Qbd Moving Forward: Opportunities and Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754276103; 5829186 JF - 46th Annual Meeting of the Drug Information Association AU - Winkle, Helen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Qbd+Moving+Forward%3A+Opportunities+and+Challenges&rft.au=Winkle%2C+Helen&rft.aulast=Winkle&rft.aufirst=Helen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fda Evaluation of Pro Measures for Regulatory Qualifi Cation to Support Claims T2 - 46th Annual Meeting of the Drug Information Association AN - 754276014; 5828834 JF - 46th Annual Meeting of the Drug Information Association AU - Papadopoulos, Elektra Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Cations KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Fda+Evaluation+of+Pro+Measures+for+Regulatory+Qualifi+Cation+to+Support+Claims&rft.au=Papadopoulos%2C+Elektra&rft.aulast=Papadopoulos&rft.aufirst=Elektra&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Cmc Reviewer'S Perspective on the Quality Overall Summary and Module 3 T2 - 46th Annual Meeting of the Drug Information Association AN - 754275770; 5829078 JF - 46th Annual Meeting of the Drug Information Association AU - Shaw, Arthur Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Cmc+Reviewer%27S+Perspective+on+the+Quality+Overall+Summary+and+Module+3&rft.au=Shaw%2C+Arthur&rft.aulast=Shaw&rft.aufirst=Arthur&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Some Regulatory Experiences in Multiregional Clinical Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754275732; 5828831 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H M Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754275732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Some+Regulatory+Experiences+in+Multiregional+Clinical+Trials&rft.au=Hung%2C+H+M&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug Master Files: An FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274887; 5829539 JF - 46th Annual Meeting of the Drug Information Association AU - Shaw, Arthur Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Drug+Master+Files%3A+An+FDA+Perspective&rft.au=Shaw%2C+Arthur&rft.aulast=Shaw&rft.aufirst=Arthur&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Opportunity and Challenges: Regulatory Pathway for Follow-on Biologics in Asia T2 - 46th Annual Meeting of the Drug Information Association AN - 754274819; 5829330 JF - 46th Annual Meeting of the Drug Information Association AU - Tzou, Meir-Chyun Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Asia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Opportunity+and+Challenges%3A+Regulatory+Pathway+for+Follow-on+Biologics+in+Asia&rft.au=Tzou%2C+Meir-Chyun&rft.aulast=Tzou&rft.aufirst=Meir-Chyun&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Statistical Considerations in Design and Analysis of Multiregional Clinical Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754274776; 5829325 JF - 46th Annual Meeting of the Drug Information Association AU - Hung, H Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Clinical trials KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Statistical+Considerations+in+Design+and+Analysis+of+Multiregional+Clinical+Trials&rft.au=Hung%2C+H&rft.aulast=Hung&rft.aufirst=H&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA's View on PDUFA: Progress and Challenges T2 - 46th Annual Meeting of the Drug Information Association AN - 754274771; 5829388 JF - 46th Annual Meeting of the Drug Information Association AU - Mullin, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA%27s+View+on+PDUFA%3A+Progress+and+Challenges&rft.au=Mullin%2C+Theresa&rft.aulast=Mullin&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Food and Drug Administration Guidance for Industry on Drug-Diagnostic Co-Development T2 - 46th Annual Meeting of the Drug Information Association AN - 754274673; 5829318 JF - 46th Annual Meeting of the Drug Information Association AU - Seyfert-Margolis, Vicki Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Food+and+Drug+Administration+Guidance+for+Industry+on+Drug-Diagnostic+Co-Development&rft.au=Seyfert-Margolis%2C+Vicki&rft.aulast=Seyfert-Margolis&rft.aufirst=Vicki&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Update--Food Irradiation T2 - 2010 Annual Meeting of the American Nuclear Society AN - 754274654; 5845512 JF - 2010 Annual Meeting of the American Nuclear Society AU - Highbarger, Lane Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Irradiation KW - Radiation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Nuclear+Society&rft.atitle=Regulatory+Update--Food+Irradiation&rft.au=Highbarger%2C+Lane&rft.aulast=Highbarger&rft.aufirst=Lane&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Nuclear+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.new.ans.org/meetings/file/151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Training Considerations for Complying with 45 Cfr Part 46 T2 - 46th Annual Meeting of the Drug Information Association AN - 754274597; 5829327 JF - 46th Annual Meeting of the Drug Information Association AU - Yoder, Freda Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Training+Considerations+for+Complying+with+45+Cfr+Part+46&rft.au=Yoder%2C+Freda&rft.aulast=Yoder&rft.aufirst=Freda&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Current Quality Challenges: Potential Qbd Solutions - Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274564; 5829336 JF - 46th Annual Meeting of the Drug Information Association AU - Jenkins, John Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Current+Quality+Challenges%3A+Potential+Qbd+Solutions+-+Regulatory+Perspective&rft.au=Jenkins%2C+John&rft.aulast=Jenkins&rft.aufirst=John&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Rems: Fda Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754274509; 5829312 JF - 46th Annual Meeting of the Drug Information Association AU - Kashoki, Mwango Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Rems%3A+Fda+Perspective&rft.au=Kashoki%2C+Mwango&rft.aulast=Kashoki&rft.aufirst=Mwango&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Food and Drug Administration Point of View T2 - 46th Annual Meeting of the Drug Information Association AN - 754274351; 5829285 JF - 46th Annual Meeting of the Drug Information Association AU - Mullin, Theresa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Food+and+Drug+Administration+Point+of+View&rft.au=Mullin%2C+Theresa&rft.aulast=Mullin&rft.aufirst=Theresa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - CDISC Content to HL7 Standard Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754273245; 5829015 JF - 46th Annual Meeting of the Drug Information Association AU - Levine, Jonathan Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754273245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=CDISC+Content+to+HL7+Standard+Update&rft.au=Levine%2C+Jonathan&rft.aulast=Levine&rft.aufirst=Jonathan&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Preapproval Inspections Field Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754273056; 5828972 JF - 46th Annual Meeting of the Drug Information Association AU - Sosa, Myriam Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Inspection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754273056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Preapproval+Inspections+Field+Perspective&rft.au=Sosa%2C+Myriam&rft.aulast=Sosa&rft.aufirst=Myriam&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Synthesizing and Communicating Available Data on Drug Use During Pregnancy and Lactation T2 - 46th Annual Meeting of the Drug Information Association AN - 754272829; 5829421 JF - 46th Annual Meeting of the Drug Information Association AU - Sahin, Leyla Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Pregnancy KW - Drug abuse KW - Data processing KW - Lactation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Synthesizing+and+Communicating+Available+Data+on+Drug+Use+During+Pregnancy+and+Lactation&rft.au=Sahin%2C+Leyla&rft.aulast=Sahin&rft.aufirst=Leyla&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biomarkers in Clinical Drug Development: Regulatory Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754272773; 5829396 JF - 46th Annual Meeting of the Drug Information Association AU - Targum, Shari AU - Wang, Sue-Jane Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Bioindicators KW - Drug development KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Biomarkers+in+Clinical+Drug+Development%3A+Regulatory+Perspective&rft.au=Targum%2C+Shari%3BWang%2C+Sue-Jane&rft.aulast=Targum&rft.aufirst=Shari&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Usan and Inn T2 - 46th Annual Meeting of the Drug Information Association AN - 754272712; 5828967 JF - 46th Annual Meeting of the Drug Information Association AU - Lewis, David Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Usan+and+Inn&rft.au=Lewis%2C+David&rft.aulast=Lewis&rft.aufirst=David&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Toxicological Perspectives of Nonclinical Testing in Botanical Drug Development T2 - 46th Annual Meeting of the Drug Information Association AN - 754272710; 5828932 JF - 46th Annual Meeting of the Drug Information Association AU - Wu, Kuei-Meng Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Toxicological+Perspectives+of+Nonclinical+Testing+in+Botanical+Drug+Development&rft.au=Wu%2C+Kuei-Meng&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Enforcement Update from Cber T2 - 46th Annual Meeting of the Drug Information Association AN - 754272625; 5828963 JF - 46th Annual Meeting of the Drug Information Association AU - Ibarra Pratt, Ele Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Surveillance and enforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Enforcement+Update+from+Cber&rft.au=Ibarra+Pratt%2C+Ele&rft.aulast=Ibarra+Pratt&rft.aufirst=Ele&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Myths and Truths about Regulatory Requirements for Co-Development of Drug-Diagnostic Pairs T2 - 46th Annual Meeting of the Drug Information Association AN - 754272548; 5829317 JF - 46th Annual Meeting of the Drug Information Association AU - Mansfield, Elizabeth Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Myths+and+Truths+about+Regulatory+Requirements+for+Co-Development+of+Drug-Diagnostic+Pairs&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Could We Do Better in Preparation of 2009 H1N1 Pandemic Vaccines? T2 - 46th Annual Meeting of the Drug Information Association AN - 754272422; 5828890 JF - 46th Annual Meeting of the Drug Information Association AU - Ye, Zhiping Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Vaccines KW - Pandemics KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Could+We+Do+Better+in+Preparation+of+2009+H1N1+Pandemic+Vaccines%3F&rft.au=Ye%2C+Zhiping&rft.aulast=Ye&rft.aufirst=Zhiping&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Supply Chain Security: Home and Abroad T2 - 46th Annual Meeting of the Drug Information Association AN - 754272297; 5828945 JF - 46th Annual Meeting of the Drug Information Association AU - Bernstein, Ilisa Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Security KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Supply+Chain+Security%3A+Home+and+Abroad&rft.au=Bernstein%2C+Ilisa&rft.aulast=Bernstein&rft.aufirst=Ilisa&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA's Draft Guidance for Industry on Noninferiority Trials: Why It Is Needed and Key Features T2 - 46th Annual Meeting of the Drug Information Association AN - 754272288; 5828886 JF - 46th Annual Meeting of the Drug Information Association AU - O'Neill, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA%27s+Draft+Guidance+for+Industry+on+Noninferiority+Trials%3A+Why+It+Is+Needed+and+Key+Features&rft.au=O%27Neill%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Advisory Committees: Offi ce of New Drugs Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754272235; 5828882 JF - 46th Annual Meeting of the Drug Information Association AU - Justice, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Advisory committees KW - Drugs KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Advisory+Committees%3A+Offi+ce+of+New+Drugs+Perspective&rft.au=Justice%2C+Robert&rft.aulast=Justice&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Electronic Medical Data, Public Health Decisions, and Statisticians: An FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754271377; 5829044 JF - 46th Annual Meeting of the Drug Information Association AU - O'Neill, Robert Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Statisticians KW - Public health KW - FDA KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Electronic+Medical+Data%2C+Public+Health+Decisions%2C+and+Statisticians%3A+An+FDA+Perspective&rft.au=O%27Neill%2C+Robert&rft.aulast=O%27Neill&rft.aufirst=Robert&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - RPS Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754271240; 5829014 JF - 46th Annual Meeting of the Drug Information Association AU - Garvey, Patricia Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=RPS+Update&rft.au=Garvey%2C+Patricia&rft.aulast=Garvey&rft.aufirst=Patricia&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Chemistry, Manufacturing, and Controls Information Recommended for a Botanical Drug Product T2 - 46th Annual Meeting of the Drug Information Association AN - 754270745; 5828933 JF - 46th Annual Meeting of the Drug Information Association AU - Agarwal, Rajiv Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Chemistry%2C+Manufacturing%2C+and+Controls+Information+Recommended+for+a+Botanical+Drug+Product&rft.au=Agarwal%2C+Rajiv&rft.aulast=Agarwal&rft.aufirst=Rajiv&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Current Regulatory Jurisdiction, Procedures, and Considerations T2 - 46th Annual Meeting of the Drug Information Association AN - 754270493; 5829409 JF - 46th Annual Meeting of the Drug Information Association AU - Folkendt, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Jurisdiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Current+Regulatory+Jurisdiction%2C+Procedures%2C+and+Considerations&rft.au=Folkendt%2C+Michael&rft.aulast=Folkendt&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Personalized Medicine: Food and Drug Administration Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754270275; 5829320 JF - 46th Annual Meeting of the Drug Information Association AU - Kalush, Francis Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Personalized+Medicine%3A+Food+and+Drug+Administration+Perspective&rft.au=Kalush%2C+Francis&rft.aulast=Kalush&rft.aufirst=Francis&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of Spontaneous Reporting in the Evaluation of Pediatric Drug Safety T2 - 46th Annual Meeting of the Drug Information Association AN - 754270204; 5829295 JF - 46th Annual Meeting of the Drug Information Association AU - McMahon, Ann Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drug development KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Role+of+Spontaneous+Reporting+in+the+Evaluation+of+Pediatric+Drug+Safety&rft.au=McMahon%2C+Ann&rft.aulast=McMahon&rft.aufirst=Ann&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fda Point of View T2 - 46th Annual Meeting of the Drug Information Association AN - 754269850; 5829202 JF - 46th Annual Meeting of the Drug Information Association AU - Pan, Gerald Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Fda+Point+of+View&rft.au=Pan%2C+Gerald&rft.aulast=Pan&rft.aufirst=Gerald&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754269531; 5829081 JF - 46th Annual Meeting of the Drug Information Association AU - Ball, Leslie Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=FDA+Perspective&rft.au=Ball%2C+Leslie&rft.aulast=Ball&rft.aufirst=Leslie&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Ddmac Direct-to-Consumer Update T2 - 46th Annual Meeting of the Drug Information Association AN - 754268852; 5828984 JF - 46th Annual Meeting of the Drug Information Association AU - Sullivan, Helen Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Ddmac+Direct-to-Consumer+Update&rft.au=Sullivan%2C+Helen&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pharmacognosy Review of Botanical Drug Applications T2 - 46th Annual Meeting of the Drug Information Association AN - 754268610; 5828931 JF - 46th Annual Meeting of the Drug Information Association AU - Dou, Jinhui Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Reviews KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Pharmacognosy+Review+of+Botanical+Drug+Applications&rft.au=Dou%2C+Jinhui&rft.aulast=Dou&rft.aufirst=Jinhui&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - What Are the Key Regulatory Principles That Will Give Confi Dence to Regulators for Acceptance of Foreign Clinical Data to Be Used as Pivotal in the Assessment of New Medicines for Approval? T2 - 46th Annual Meeting of the Drug Information Association AN - 754268360; 5829307 JF - 46th Annual Meeting of the Drug Information Association AU - Lumpkin, Murray Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=What+Are+the+Key+Regulatory+Principles+That+Will+Give+Confi+Dence+to+Regulators+for+Acceptance+of+Foreign+Clinical+Data+to+Be+Used+as+Pivotal+in+the+Assessment+of+New+Medicines+for+Approval%3F&rft.au=Lumpkin%2C+Murray&rft.aulast=Lumpkin&rft.aufirst=Murray&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Federal Comparative Effectiveness Research: Current and Future Directions T2 - 46th Annual Meeting of the Drug Information Association AN - 754266848; 5829037 JF - 46th Annual Meeting of the Drug Information Association AU - Clancy, Carolyn Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Federal+Comparative+Effectiveness+Research%3A+Current+and+Future+Directions&rft.au=Clancy%2C+Carolyn&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Manufacturing Facility Information Needed in the Drug Application T2 - 46th Annual Meeting of the Drug Information Association AN - 754266647; 5828973 JF - 46th Annual Meeting of the Drug Information Association AU - Folkendt, Michael Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Drugs KW - Manufacturing industry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754266647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Manufacturing+Facility+Information+Needed+in+the+Drug+Application&rft.au=Folkendt%2C+Michael&rft.aulast=Folkendt&rft.aufirst=Michael&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Making a Difference: A Case Study on Developing Effective Training T2 - 2010 Conference and Exposition of the American Society of Safety Engineers on Professional Development AN - 754265486; 5823908 JF - 2010 Conference and Exposition of the American Society of Safety Engineers on Professional Development AU - Cullen, Elaine Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Case studies KW - Training KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Society+of+Safety+Engineers+on+Professional+Development&rft.atitle=Making+a+Difference%3A+A+Case+Study+on+Developing+Effective+Training&rft.au=Cullen%2C+Elaine&rft.aulast=Cullen&rft.aufirst=Elaine&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Society+of+Safety+Engineers+on+Professional+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.asse.org/education/pdc10/docs/ASSE-SAFETY-2010-60-pg.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Supplier Quality Management: A Risk-based Approach T2 - 46th Annual Meeting of the Drug Information Association AN - 754263265; 5829485 JF - 46th Annual Meeting of the Drug Information Association AU - Wolfgang, Steven Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Risks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Supplier+Quality+Management%3A+A+Risk-based+Approach&rft.au=Wolfgang%2C+Steven&rft.aulast=Wolfgang&rft.aufirst=Steven&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754262809; 5829135 JF - 46th Annual Meeting of the Drug Information Association AU - Scanlon, James Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+Perspective&rft.au=Scanlon%2C+James&rft.aulast=Scanlon&rft.aufirst=James&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Point of View from the FDA T2 - 46th Annual Meeting of the Drug Information Association AN - 754262419; 5828825 JF - 46th Annual Meeting of the Drug Information Association AU - Love, Patricia Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754262419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Point+of+View+from+the+FDA&rft.au=Love%2C+Patricia&rft.aulast=Love&rft.aufirst=Patricia&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - US GCP Requirements for Global Trials T2 - 46th Annual Meeting of the Drug Information Association AN - 754261495; 5829370 JF - 46th Annual Meeting of the Drug Information Association AU - Mulinde, Jean Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=US+GCP+Requirements+for+Global+Trials&rft.au=Mulinde%2C+Jean&rft.aulast=Mulinde&rft.aufirst=Jean&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Health Information Uniformity: Essential for Evaluation and Effi ciency T2 - 46th Annual Meeting of the Drug Information Association AN - 754261204; 5829051 JF - 46th Annual Meeting of the Drug Information Association AU - Fitzmaurice, J Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=Health+Information+Uniformity%3A+Essential+for+Evaluation+and+Effi+ciency&rft.au=Fitzmaurice%2C+J&rft.aulast=Fitzmaurice&rft.aufirst=J&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Statistical Reviewer's Perspective: Making Sure that Everything is Ready to Go on Day 1 T2 - 46th Annual Meeting of the Drug Information Association AN - 754254761; 5829277 JF - 46th Annual Meeting of the Drug Information Association AU - Zhou, Feng Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=A+Statistical+Reviewer%27s+Perspective%3A+Making+Sure+that+Everything+is+Ready+to+Go+on+Day+1&rft.au=Zhou%2C+Feng&rft.aulast=Zhou&rft.aufirst=Feng&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Establishment of the Taiwan Food and Drug Administration: Future Perspective T2 - 46th Annual Meeting of the Drug Information Association AN - 754254241; 5829033 JF - 46th Annual Meeting of the Drug Information Association AU - Kang, Jaw-Jou Y1 - 2010/06/13/ PY - 2010 DA - 2010 Jun 13 KW - Taiwan KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754254241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.atitle=The+Establishment+of+the+Taiwan+Food+and+Drug+Administration%3A+Future+Perspective&rft.au=Kang%2C+Jaw-Jou&rft.aulast=Kang&rft.aufirst=Jaw-Jou&rft.date=2010-06-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Drug+Information+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.diahome.org/DIAHome/resources/content.aspx?type=eopdf&file= LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The role of ethnobotany in policy and commerce T2 - 51st Annual Meeting of the Society for Economic Botany AN - 754316704; 5872258 JF - 51st Annual Meeting of the Society for Economic Botany AU - Casper, Steven Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Ethnobotany KW - Policies KW - Commerce KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754316704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Society+for+Economic+Botany&rft.atitle=The+role+of+ethnobotany+in+policy+and+commerce&rft.au=Casper%2C+Steven&rft.aulast=Casper&rft.aufirst=Steven&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Society+for+Economic+Botany&rft.issn=&rft_id=info:doi/ L2 - http://www.econbot.org/_organization_/07_annual_meetings/meetings_by_y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Early Postnatal Anesthesia and Long Lasting Cognitive Deficits in Rhesus Monkeys T2 - 26th International Neurotoxicology Conference AN - 754308765; 5864458 JF - 26th International Neurotoxicology Conference AU - Paule, M AU - Li, M. AU - Zou, X AU - Slikker Jr, W AU - Wang, C AU - Hotchkiss, C AU - Hanig, J Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Anesthesia KW - Cognitive ability KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754308765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Neurotoxicology+Conference&rft.atitle=Early+Postnatal+Anesthesia+and+Long+Lasting+Cognitive+Deficits+in+Rhesus+Monkeys&rft.au=Paule%2C+M%3BLi%2C+M.%3BZou%2C+X%3BSlikker+Jr%2C+W%3BWang%2C+C%3BHotchkiss%2C+C%3BHanig%2C+J&rft.aulast=Paule&rft.aufirst=M&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Neurotoxicology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.neurotoxicology.com/conf2009/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effect of Chronic MPTP Administration on Glycolysis and TCA Cycle Pathways in Mouse Model of Parkinson's Disease T2 - 26th International Neurotoxicology Conference AN - 754308204; 5864454 JF - 26th International Neurotoxicology Conference AU - Sonko, Bakary AU - Schmitt, Tom AU - Beger, Richard AU - Sakar, Sumit AU - Syed, Ali AU - Boros, Laszlo Y1 - 2010/06/06/ PY - 2010 DA - 2010 Jun 06 KW - Parkinson's disease KW - Animal models KW - Movement disorders KW - Neurodegenerative diseases KW - Tricarboxylic acid cycle KW - Glycolysis KW - MPTP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754308204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+International+Neurotoxicology+Conference&rft.atitle=Effect+of+Chronic+MPTP+Administration+on+Glycolysis+and+TCA+Cycle+Pathways+in+Mouse+Model+of+Parkinson%27s+Disease&rft.au=Sonko%2C+Bakary%3BSchmitt%2C+Tom%3BBeger%2C+Richard%3BSakar%2C+Sumit%3BSyed%2C+Ali%3BBoros%2C+Laszlo&rft.aulast=Sonko&rft.aufirst=Bakary&rft.date=2010-06-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+International+Neurotoxicology+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.neurotoxicology.com/conf2009/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Considerations for Organ Dysfunction Studies T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839658636; 5907180 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Huang, Shiew-Mei Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Organs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Regulatory+Considerations+for+Organ+Dysfunction+Studies&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Career Options in Government T2 - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AN - 839641321; 5903975 JF - 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO 2010) AU - Pazdur, Richard Y1 - 2010/06/04/ PY - 2010 DA - 2010 Jun 04 KW - {Q1} KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.atitle=Career+Options+in+Government&rft.au=Pazdur%2C+Richard&rft.aulast=Pazdur&rft.aufirst=Richard&rft.date=2010-06-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Society+of+Clinical+Oncology+%28ASCO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asco.org/ASCOv2/Department%20Content/IMedia/Downloads/2010% LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Prevention of Mental Disorders and Substance Abuse Among Children, Youth and Young Adults T2 - 2010 Conference of the Institute on Social Exclusion (ISE 2010) AN - 754299168; 5858890 JF - 2010 Conference of the Institute on Social Exclusion (ISE 2010) AU - Thompson, Kenneth Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 KW - Mental disorders KW - Prevention KW - Children KW - Young adults KW - Substance abuse KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754299168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+of+the+Institute+on+Social+Exclusion+%28ISE+2010%29&rft.atitle=Prevention+of+Mental+Disorders+and+Substance+Abuse+Among+Children%2C+Youth+and+Young+Adults&rft.au=Thompson%2C+Kenneth&rft.aulast=Thompson&rft.aufirst=Kenneth&rft.date=2010-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+of+the+Institute+on+Social+Exclusion+%28ISE+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adler.edu/about/sdomh2010agenda.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Age and Sex-Related Differences in Hepatic Gene Expression during the Rat Life Cycle T2 - 2010 Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2010) AN - 754292378; 5842287 JF - 2010 Annual Meeting of the Organization for the Study of Sex Differences (OSSD 2010) AU - Kwekel, Joshua Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 KW - Life cycle KW - Age KW - Gene expression KW - Sex differences KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754292378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2010%29&rft.atitle=Age+and+Sex-Related+Differences+in+Hepatic+Gene+Expression+during+the+Rat+Life+Cycle&rft.au=Kwekel%2C+Joshua&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2010-06-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Organization+for+the+Study+of+Sex+Differences+%28OSSD+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://data.memberclicks.com/site/ossd/OSSD%202010%20Scientific%20Prog LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice AN - 746311486; 13205726 AB - Debate exists as to whether welding fume is carcinogenic, but epidemiological evidence suggests that welders are an at risk population for the development of lung cancer. Recently, we found that exposure to welding fume caused an acutely greater and prolonged lung inflammatory response in lung tumor susceptible A/J versus resistant C57BL/6J (B6) mice and a trend for increased tumor incidence after stainless steel (SS) fume exposure. Here, our objective was to examine potential strain-dependent differences in the regulation and resolution of the lung inflammatory response induced by carcinogenic (Cr and Ni abundant) or non-carcinogenic (iron abundant) metal-containing welding fumes at the transcriptome level. Mice were exposed four times by pharyngeal aspiration to 5 mg/kg iron abundant gas metal arc-mild steel (GMA-MS), Cr and Ni abundant GMA-SS fume or vehicle and were euthanized 4 and 16 weeks after the last exposure. Whole lung microarray using Illumina Mouse Ref-8 expression beadchips was done. Overall, we found that tumor susceptibility was associated with a more marked transcriptional response to both GMA-MS and -SS welding fumes. Also, Ingenuity Pathway Analysis revealed that gene regulation and expression in the top molecular networks differed between the strains at both time points post-exposure. Interestingly, a common finding between the strains was that GMA-MS fume exposure altered behavioral gene networks. In contrast, GMA-SS fume exposure chronically upregulated chemotactic and immunomodulatory genes such as CCL3, CCL4, CXCL2, and MMP12 in the A/J strain. In the GMA-SS-exposed B6 mouse, genes that initially downregulated cellular movement, hematological system development/function and immune response were involved at both time points post-exposure. However, at 16 weeks, a transcriptional switch to an upregulation for neutrophil chemotactic genes was found and included genes such as S100A8, S100A9 and MMP9. Collectively, our results demonstrate that lung tumor susceptibility may predispose the A/J strain to a prolonged dysregulation of immunomodulatory genes, thereby delaying the recovery from welding fume-induced lung inflammation. Additionally, our results provide unique insight into strain- and welding fume-dependent genetic factors involved in the lung response to welding fume. JF - Respiratory Research AU - Zeidler-Erdely, Patti C AU - Kashon, Michael L AU - Li, Shengqiao AU - Antonini, James M AD - Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, 26505, USA Y1 - 2010/06/03/ PY - 2010 DA - 2010 Jun 03 SP - 70 PB - BioMed Central Ltd., Middlesex House London W1T 4LB UK VL - 11 IS - 1 SN - 1465-9921, 1465-9921 KW - Toxicology Abstracts; Immunology Abstracts KW - Genetic factors KW - Pharynx KW - CCL4 protein KW - Heavy metals KW - Development KW - Immunomodulation KW - DNA microarrays KW - Gene expression KW - Welding KW - Steel KW - Lung cancer KW - Fumes KW - Chromium KW - CCL3 protein KW - Leukocytes (neutrophilic) KW - Transcription KW - Tumors KW - Inflammation KW - Lung KW - Gene regulation KW - Gelatinase B KW - Immune response KW - Iron KW - stainless steel KW - F 06915:Cancer Immunology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746311486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+Research&rft.atitle=Response+of+the+mouse+lung+transcriptome+to+welding+fume%3A+effects+of+stainless+and+mild+steel+fumes+on+lung+gene+expression+in+A%2FJ+and+C57BL%2F6J+mice&rft.au=Zeidler-Erdely%2C+Patti+C%3BKashon%2C+Michael+L%3BLi%2C+Shengqiao%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2010-06-03&rft.volume=11&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Respiratory+Research&rft.issn=14659921&rft_id=info:doi/10.1186%2F1465-9921-11-70 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Genetic factors; CCL4 protein; Pharynx; Fumes; Chromium; Heavy metals; CCL3 protein; Leukocytes (neutrophilic); Transcription; Development; Tumors; DNA microarrays; Immunomodulation; Inflammation; Gene expression; Lung; Gene regulation; Welding; Immune response; Steel; Gelatinase B; Iron; Lung cancer; stainless steel DO - http://dx.doi.org/10.1186/1465-9921-11-70 ER - TY - JOUR T1 - Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies AN - 744701515; 13114147 AB - Background The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. Methods We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P sub(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P sub(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P sub(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Conclusions Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study. JF - Journal of the National Cancer Institute AU - Zhang, Xuehong AU - Albanes, Demetrius AU - Beeson, WLawrence AU - van den Brandt, Piet A AU - Buring, Julie E AU - Flood, Andrew AU - Freudenheim, Jo L AU - Giovannucci, Edward L AU - Goldbohm, RAlexandra AU - Jaceldo-Siegl, Karen AU - Jacobs, Eric J AU - Krogh, Vittorio AU - Larsson, Susanna C AU - Marshall, James R AU - McCullough, Marjorie L AU - Miller, Anthony B AU - Robien, Kim AU - Rohan, Thomas E AU - Schatzkin, Arthur AU - Sieri, Sabina AU - Spiegelman, Donna AU - Virtamo, Jarmo AU - Wolk, Alicja AU - Willett, Walter C AU - Zhang, Shumin M AU - Smith-Warner, Stephanie A AD - Affiliations of authors: Department of Nutrition (XZ, ELG, WCW, SAS-W), Department of Epidemiology (XZ, JEB, ELG, DS, WCW, SAS-W), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Nutritional Epidemiology Branch (DA) and Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (AS), National Cancer Institute, National Institute of Health, Bethesda, MD; The Center for Health Research, Loma Linda University School of Public Health, Loma Linda, CA (WLB, KJ-S); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands (PAvdB); Division of Preventive Medicine, Department of Medicine (JEB, SMZ) and Channing Laboratory, Department of Medicine (ELG, WCW), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY (JLF); Department of Foo, pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu pooling@hsphsun2.harvard.edu Y1 - 2010/06/02/ PY - 2010 DA - 2010 Jun 02 SP - 771 EP - 783 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 11 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Coffee KW - Physical activity KW - Statistical analysis KW - tumors KW - tea KW - Models KW - Smoking KW - body mass KW - Tea KW - physical activity KW - Ethanol KW - Sex KW - Alcohol KW - Data processing KW - Beverages KW - coffee KW - Tumors KW - Colon cancer KW - Cancer KW - Drinking behavior KW - Body mass index KW - X 24380:Social Poisons & Drug Abuse KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744701515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Risk+of+Colon+Cancer+and+Coffee%2C+Tea%2C+and+Sugar-Sweetened+Soft+Drink+Intake%3A+Pooled+Analysis+of+Prospective+Cohort+Studies&rft.au=Zhang%2C+Xuehong%3BAlbanes%2C+Demetrius%3BBeeson%2C+WLawrence%3Bvan+den+Brandt%2C+Piet+A%3BBuring%2C+Julie+E%3BFlood%2C+Andrew%3BFreudenheim%2C+Jo+L%3BGiovannucci%2C+Edward+L%3BGoldbohm%2C+RAlexandra%3BJaceldo-Siegl%2C+Karen%3BJacobs%2C+Eric+J%3BKrogh%2C+Vittorio%3BLarsson%2C+Susanna+C%3BMarshall%2C+James+R%3BMcCullough%2C+Marjorie+L%3BMiller%2C+Anthony+B%3BRobien%2C+Kim%3BRohan%2C+Thomas+E%3BSchatzkin%2C+Arthur%3BSieri%2C+Sabina%3BSpiegelman%2C+Donna%3BVirtamo%2C+Jarmo%3BWolk%2C+Alicja%3BWillett%2C+Walter+C%3BZhang%2C+Shumin+M%3BSmith-Warner%2C+Stephanie+A&rft.aulast=Zhang&rft.aufirst=Xuehong&rft.date=2010-06-02&rft.volume=102&rft.issue=11&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjq107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Coffee; Risk assessment; Beverages; Data processing; Physical activity; Statistical analysis; Colon cancer; Tumors; Models; Smoking; Tea; Drinking behavior; Body mass index; Sex; Ethanol; Alcohol; body mass; coffee; tumors; physical activity; tea; Cancer DO - http://dx.doi.org/10.1093/jnci/djq107 ER - TY - JOUR T1 - Small noncoding RNAs: Biogenesis, function, and emerging significance in toxicology AN - 883022878; 15242294 AB - In recent years, the discovery of small ncRNAs (noncoding RNAs) has unveiled a slew of powerful riboregulators of gene expression. So far, many different types of small ncRNAs have been described. Of these, miRNAs (microRNAs), siRNAs (small interfering RNAs), and piRNAs (Piwi-interacting RNAs) have been studied in more detail. A significant fraction of genes in most organisms and tissues is targets of these small ncRNAs. Because these tiny RNAs are turning out to be important regulators of gene and genome expression, their aberrant expression profiles are expected to be associated with cellular dysfunction and disease. In fact, an ever-increasing number of studies have implicated miRNAs and siRNAs in human health and disease ranging from metabolic disorders to diseases of various organ systems as well as various forms of cancer. Nevertheless, despite the flurry of research on these small ncRNAs, many aspects of their biology still remain to be understood. The following discussion focuses on some aspects of the biogenesis and function of small ncRNAs with major emphasis on miRNAs since these are the most widespread endogenous small ncRNAs that have been called 'micromanagers' of gene expression. Their emerging significance in toxicology is also discussed. [copy 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:195-216, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20325 JF - Journal of Biochemical and Molecular Toxicology AU - Choudhuri, Supratim Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 195 EP - 216 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 3 SN - 1099-0461, 1099-0461 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Environment Abstracts; Toxicology Abstracts KW - Biochemistry KW - Cancer KW - Gene expression KW - Genomes KW - Internet KW - Metabolic disorders KW - Organs KW - Toxicology KW - metabolic disorders KW - miRNA KW - non-coding RNA KW - siRNA KW - X 24490:Other KW - N 14830:RNA KW - W 30965:Miscellaneous, Reviews KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883022878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=Small+noncoding+RNAs%3A+Biogenesis%2C+function%2C+and+emerging+significance+in+toxicology&rft.au=Choudhuri%2C+Supratim&rft.aulast=Choudhuri&rft.aufirst=Supratim&rft.date=2010-06-01&rft.volume=24&rft.issue=3&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10990461&rft_id=info:doi/10.1002%2Fjbt.20325 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jbt.20325/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-08-10 N1 - SubjectsTermNotLitGenreText - Genomes; Gene expression; siRNA; Metabolic disorders; miRNA; non-coding RNA; Cancer; Internet; metabolic disorders; Biochemistry; Organs; Toxicology DO - http://dx.doi.org/10.1002/jbt.20325 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHROMIUM PICOLINATE MONOHYDRATE (CAS NO. 27882-76-4) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) AN - 878891980; 20725156 AB - Chromium is a metal that exists in a variety of valence states, depending on surrounding conditions and what other atoms it is bound to. The most stable forms are metallic chromium, trivalent chromium (chromium III), and hexavalent chromium (chromium VI). While chromium VI has been shown to cause cancer in other animal studies, chromium III is an essential trace element and is ingested in food and dietary supplements. We gave feed containing 2,000, 10,000, or 50,000 parts per million (ppm) of chromium picolinate to groups of 50 male and female rats and mice for two years. Similar groups of animals were given feed with no chemical added and served as the control groups. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival of all exposed groups of animals was similar to their controls. The rate of adenomas of the preputial gland was greater in male rats receiving 10,000 ppm chromium picolinate than in the control group. We conclude that the occurence of preputial gland adenomas in one group of male rats was possibly associated with exposure to chromium picolinate. We conclude that chromium picolinate did not cause cancer in female rats or in male or female mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 EP - 194 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Picolinic Acids KW - picolinic acid KW - Toxicology KW - Rodents KW - Chromium compounds KW - Rats KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Carcinogenicity Tests KW - Picolinic Acids -- pharmacokinetics KW - Mice KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Picolinic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+CHROMIUM+PICOLINATE+MONOHYDRATE+%28CAS+NO.+27882-76-4%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28FEED+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878891978 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 878891903 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878891903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=556&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 878683499 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=544&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIBROMOACETONITRILE (CAS NO. 3252-43-5) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES) AN - 878683474; 20725153 AB - Dibromoacetonitrile occurs in chlorinated drinking water that contains bromine and interacts with organic matter. We studied the effects of dibromoacetonitrile in drinking water on male and female rats and mice to identify potential toxic or cancer-related hazards. We gave drinking water containing 50, 100, or 200 milligrams of dibromoacetonitrile per liter of water to groups of 50 male and female rats and mice for two years. Control animals received the same tap water with no chemical added. At the end of the study, tissues from more than 40 sites were examined for every animal. Survival was similar for animals receiving dibromoacetonitrile and the controls. Male and female rats receiving dibromoacetonitrile had increased rates of squamous cell adenomas or carcinomas of the mouth (oral mucosa or tongue). Two male rats receiving 200 mg/L had rare adenomas of the glandular stomach. There were a few instances of skin tumors in female rats receiving 100 or 200 mg/L. Male and female mice exposed to dibromoacetonitrile had increased rates of squamous cell papillomas of the forestomach. There were also slight increases in the occurrence of liver tumors in male mice. We conclude that dibromoacetonitrile in the drinking water caused cancer of the oral cavity in male and female rats and of the glandular stomach in male rats. We conclude that dibromoacetonitrile caused cancer of the forestomach in male and female mice. Tumors of the skin in female rats and of the liver in male mice may also have been related to exposure to dibromoacetonitrile. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 EP - 193 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Acetonitriles KW - dibromoacetonitrile KW - Drinking water KW - Toxicology KW - Rodents KW - Cancer KW - Health hazards KW - Drinking KW - Animals KW - Reproduction -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Acetonitriles -- metabolism KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Body Weight -- drug effects KW - Carcinogenicity Tests KW - Female KW - Male KW - Neoplasms, Experimental -- chemically induced KW - Acetonitriles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/878683474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+DIBROMOACETONITRILE+%28CAS+NO.+3252-43-5%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=544&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Evaluation of Child Care Subsidy Strategies: Implementation of Three Language and Literacy Interventions in Project Upgrade. OPRE 2011-4 AN - 864941700; ED517544 AB - This report describes the design and implementation of the three interventions tested in Project Upgrade, one of four experiments conducted as part of the Evaluation of Child Care Subsidy Strategies. The evaluation was a multi-site, multi-year effort to determine whether and how different child care subsidy policies and procedures and quality improvement efforts help low-income parents obtain and hold onto jobs and improve outcomes for children. Study staff worked with states and communities across the country to identify significant issues and develop hypotheses about the use of child care subsidy funds that could be rigorously tested in a series of experiments. A guiding principle of the study was that state (or community) interests and preferences should play a large role in the choice of research topics and strategies. Findings of this study include: (1) The initial observations, conducted before the interventions, showed that, across all groups, teachers engaged in few of the behaviors and interactions that have been shown to support children's development of language and literacy skills; (2) Within six months of training, in Spring 2004, all three language/literacy interventions produced significant impacts on teacher behaviors and interactions with children that supported their language and literacy development; by Spring 2005, these impacts were generally more pronounced, and there were significant impacts on the number of classroom activities that involved literacy, and on literacy resources in the classroom; (3) The interventions had significant positive impacts on teacher behavior. These impacts were generally stronger for teachers whose primary language was Spanish than for their English-speaking counterparts; (4) Two of the three interventions, "Ready, Set, Leap" and "Breakthrough to Literacy", had significant impacts on all four measures of emergent literacy outcomes for children: definitional vocabulary; phonological awareness; knowledge and understanding of print and an overall index of early literacy. The impact of the two effective interventions was much greater for children in classrooms with Spanish-speaking teachers than for children in classrooms with English-speaking teachers; (5) The two interventions that had impacts on child outcomes brought children close to or above the national norms on three of the four outcomes. On the fourth, definitional vocabulary, although children in the two treatment groups had significantly higher scores, they still lagged considerably behind the national norms. The impacts represent between four and nine months of developmental growth, depending on the outcome; (6) The interventions resulted in a substantial increase in the time spent on language and literacy activities, both teacher-directed and child-initiated. This did not eliminate other important developmental activities. Rather, time spent on each of the other activities was reduced slightly; and (7) There was a small but significant relationship between teachers' educational attainment and some aspects of their behavior with children before the interventions. The training and on-going mentoring provided as an integral part of the interventions eliminated this relationship. That is, as a result of the training and mentoring, less-educated teachers looked remarkably similar to their better-educated counterparts in the extent to which they provided activities that supported literacy. Teachers' educational qualifications did not modify the impacts of the interventions on child outcomes. Appendices include: (1) Creation of Implementation Indexes; and (2) Observation Measures for Language and Literacy Instruction (OMLIT). (Contains 4 tables, 7 exhibits and 26 footnotes.) AU - Layzer, Carolyn J. AU - Layzer, Jean I. AU - Wolf, Anne Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 68 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Florida KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Program Effectiveness KW - Language Acquisition KW - Intervention KW - Child Care KW - Educational Attainment KW - Reading Aloud to Others KW - Knowledge Level KW - Program Implementation KW - Child Development KW - Emergent Literacy KW - Program Development KW - Spanish Speaking KW - Program Evaluation KW - Financial Support KW - Vocabulary Development KW - Low Income Groups KW - Coaching (Performance) KW - Teacher Behavior KW - Teacher Influence KW - Language Skills KW - Observation KW - Staff Development KW - English (Second Language) KW - Mentors KW - Family Involvement KW - Oral Language KW - Phonological Awareness KW - Check Lists KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941700?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Evaluation of Child Care Subsidy Strategies: Massachusetts Family Child Care Study AN - 864941045; ED517545 AB - This report presents findings from the Massachusetts Family Child Care study, a two-year evaluation of the impacts of an early childhood education program on providers and children in family child care. The program--"LearningGames"--is designed to train caregivers to stimulate children's cognitive, language, and social-emotional development. The evaluation of "LearningGames" is one of four state experiments conducted as part of the Evaluation of Child Care Subsidy Strategies. The study is being conducted by Abt Associates Inc, with its research partners MDRC and the National Center for Children in Poverty of Columbia University, under a contract with the Administration for Children and Families within the U.S. Department of Health and Human Services. The goal of the evaluation is to provide information that states and local communities can use to inform their decisions about the use of child care subsidy and child care quality improvement funds. Appendices include: (1) Attrition by Agency; (2) Child Impact Analyses; and (3) Observation Coding Forms. (Contains 29 exhibits and 21 footnotes.) [For "Evaluation of Child Care Subsidy Strategies: Massachusetts Family Child Care Study. Executive Summary", see ED517538.] AU - Collins, Ann AU - Goodson, Barbara AU - Luallen, Jeremy AU - Fountain, Alyssa Rulf AU - Checkoway, Amy Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 138 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Massachusetts KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Program Effectiveness KW - Barriers KW - Language Acquisition KW - Childrens Literature KW - Child Care KW - Reading Aloud to Others KW - Skill Development KW - Outcomes of Education KW - Caregivers KW - Home Programs KW - Educational Games KW - Program Implementation KW - Disadvantaged Youth KW - Social Development KW - Certification KW - Financial Support KW - Interaction KW - Low Income Groups KW - Cognitive Development KW - Young Children KW - Training KW - Home Visits KW - Staff Development KW - Emotional Development KW - Learning Activities KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864941045?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - HIV/AIDS: Risk & Protective Behaviors among American Young Adults, 2004-2008. Monitoring the Future. NIH Publication No. 10-7586 AN - 851227901; ED514378 AB - Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. The study is supported under a series of investigator-initiated, competing research grants from the National Institute on Drug Abuse, and has been conducted annually by the University of Michigan's Institute for Social Research since 1975. The present volume is being published separately for the first time this year. Whereas the other three MTF monographs address the topic of substance use, the present volume focuses on a range of behaviors related to the spread of the human immunodeficiency virus (HIV) responsible for the acquired immunodeficiency syndrome (AIDS). The population under study is young adult high school graduates ages 21-30 in the general population. Previously, findings on this subject were presented as a final chapter in "Volume II" based on measures of HIV/AIDS risk and protective behaviors that were introduced into the MTF follow-up studies in 2004. However, as the content expanded considerably and the historical period lengthened, a separate volume on this important topic seemed warranted. (Contains 18 tables and 3 figures.) [For the related reports, see "Overview of Key Findings" (ED514371), 'Volume I" (ED514370), and "Volume II" (ED514367).] AU - Johnston, Lloyd D. AU - O'Malley, Patrick M. AU - Bachman, Jerald G. AU - Schulenberg, John E. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 63 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - High School Graduates KW - Gender Differences KW - Grants KW - Young Adults KW - Sexuality KW - Risk KW - Contraception KW - Diagnostic Tests KW - Sexually Transmitted Diseases KW - Incidence KW - Health Behavior KW - Acquired Immunodeficiency Syndrome (AIDS) KW - Drug Use KW - Trend Analysis KW - Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851227901?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - Antiviral activity of selected antimicrobial peptides against vaccinia virus AN - 807258838; 13199675 AB - Antimicrobial peptides (AMPs) are gaining importance as effective therapeutic alternatives to conventional antibiotics. Recently we have shown that a set of nine synthetic antimicrobial peptides, four originating from thrombin-induced human platelet-derived antimicrobial proteins named PD1-PD4 and five synthetic repeats of arginine-tryptophan (RW) repeats (RW1-5) demonstrate antibacterial activity in plasma and platelets. Using WR strain of vaccinia virus (VV) as a model virus for enveloped virus in the present study, we tested the same nine synthetic peptides for their antiviral activity. A cell culture-based standard plaque reduction assay was utilized to estimate antiviral effectiveness of the peptides. Our analysis revealed that peptides PD3, PD4, and RW3 were virucidal against VV with PD3 demonstrating the highest antiviral activity of 100-fold reduction in viral titers, whereas, PD4 and RW3 peptide treatments resulted in 10-30-fold reduction. The EC50 values of PD3, PD4 and RW3 were found to be 40 mu g/ml, 50 mu g/ml and 6.5 mu M, respectively. In VV-spiked plasma samples, the virucidal activity of PD3, PD4 and RW3 was close to 100% (90-100-fold reduction). Overall, the present study constitutes a new proof-of-concept in developing peptide therapeutics for vaccinia virus infections in biothreat scenarios and as in vitro viral reduction agents. JF - Antiviral Research AU - Mohan, Ketha VK AU - Rao, Shilpakala Sainath AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, United States, krishna.ketha@fda.hhs.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 306 EP - 311 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 86 IS - 3 SN - 0166-3542, 0166-3542 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - AMPs KW - RW peptides KW - Platelet-derived peptides KW - Microbicidal KW - pfu KW - Vaccinia virus KW - synthetic peptides KW - Antibacterial activity KW - Platelets KW - Antibiotics KW - Plaques KW - Antiviral activity KW - Infection KW - Antimicrobial peptides KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807258838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Antiviral+activity+of+selected+antimicrobial+peptides+against+vaccinia+virus&rft.au=Mohan%2C+Ketha+VK%3BRao%2C+Shilpakala+Sainath%3BAtreya%2C+Chintamani+D&rft.aulast=Mohan&rft.aufirst=Ketha&rft.date=2010-06-01&rft.volume=86&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2010.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - synthetic peptides; Antibacterial activity; Platelets; Plaques; Antibiotics; Infection; Antiviral activity; Antimicrobial peptides; Antimicrobial agents; Vaccinia virus DO - http://dx.doi.org/10.1016/j.antiviral.2010.03.012 ER - TY - JOUR T1 - Path forward: Emerging issues and challenges AN - 754880699; 13398064 AB - The NIOSH Construction Program worked with industry stakeholders to develop a National Occupational Safety and Health Construction Agenda to target future research and activities. The Program and its partners are also cognizant that new developments can emerge over time and that research can play an important role in helping to understand and address these emerging issues. Examples of emerging issues relevant to construction safety and health are described. These include: (a) climate change and energy considerations; (b) green construction developments and opportunities; (c) new materials; (d) changes in industry structure and practice; (e) workforce developments and disparities; (f) injury underreporting and cost and risk shifting; and (g) increased interest in addressing root causes. Responding to emerging issues while maintaining a focus on fundamental longstanding issues represents an ongoing challenge for researchers and industry organizations. Additional research to understand the diffusion and adoption of research by the industry is also needed. Research accomplished to date provides a strong foundation for addressing future industry needs and trends. JF - Journal of Safety Research AU - Gillen, Matt AU - Gittleman, Janie L AD - The National Institute for Occupational Safety and Health Office of Construction Safety and Health, 395 E Street, SW, Washington, DC 20201, mgillen@cdc.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 301 EP - 306 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 3 SN - 0022-4375, 0022-4375 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Emerging Issues KW - Construction Industry changes KW - Research challenges KW - NORA National Construction Agenda KW - Green construction KW - Injuries KW - Occupational safety KW - Climate change KW - Diffusion KW - stakeholders KW - Construction industry KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Path+forward%3A+Emerging+issues+and+challenges&rft.au=Gillen%2C+Matt%3BGittleman%2C+Janie+L&rft.aulast=Gillen&rft.aufirst=Matt&rft.date=2010-06-01&rft.volume=41&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Injuries; Climate change; Occupational safety; Diffusion; stakeholders; Construction industry DO - http://dx.doi.org/10.1016/j.jsr.2010.04.005 ER - TY - JOUR T1 - Fall arrest characteristics of a scissor lift AN - 754880199; 13398055 AB - Problem - Census of Fatal Occupational Injuries (CFOI) data indicate 306 aerial lift fatalities between 1992-2003. Seventy-eight of these fatalities specifically involved scissor lifts. Members of standards committees have requested that NIOSH conduct research to determine the effects of safety-control practices related to using fall-protection systems for scissor lifts. Method - This research examined the structural and dynamic stability of a scissor lift subjected to fall arrest forces. This was accomplished by conducting drop tests from a scissor lift. Anchorage locations evaluated included manufacturer-supplied anchorage points on the scissor lift platform as well as mid-rail and top-rail locations. Results - Preliminary drop tests determined that a 2400 lb maximum arrest force (MAF) could be generated by dropping 169 lb through a fall height of 36" using Nystron[registered] rope as a lanyard. The scissor lift maintained structural and dynamic stability for all drop tests when fully extended and on an incline. Discussion - Anchoring a fall arrest system to either the mid-rail or top-rail is not a recommended practice by the scissor lift manufacturer. Anchor points are provided on the platform floor of the scissor lift for this purpose. However, our results demonstrate that the mid-rail and top-rail absorb substantial energy from an arrested fall and may have potential as appropriate anchorage points. Impact to Industry - Employers and workers should consider implementing fall arrest systems when using scissor lifts as part of their overall risk mitigation plan for fall injury prevention. JF - Journal of Safety Research AU - Harris, James R AU - Powers, John R AU - Pan, Christopher S AU - Boehler, Brad AD - National Institute for Occupational Safety and Health, Morgantown, WV USA, JHarris@cdc.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 213 EP - 220 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 3 SN - 0022-4375, 0022-4375 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Scissor lift KW - Aerial lift KW - Fall arrest KW - census KW - Mortality KW - mitigation KW - arrests KW - Injuries KW - Occupational safety KW - prevention KW - committees KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Fall+arrest+characteristics+of+a+scissor+lift&rft.au=Harris%2C+James+R%3BPowers%2C+John+R%3BPan%2C+Christopher+S%3BBoehler%2C+Brad&rft.aulast=Harris&rft.aufirst=James&rft.date=2010-06-01&rft.volume=41&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - census; Mortality; mitigation; Injuries; arrests; Occupational safety; prevention; committees DO - http://dx.doi.org/10.1016/j.jsr.2010.01.004 ER - TY - JOUR T1 - The NIOSH Construction Program: Research to practice, impact, and developing a National Construction Agenda AN - 754880179; 13398063 AB - The U.S. National Institute for Occupational Safety and Health (NIOSH) conducts research to improve and protect the health and safety of workers. This paper describes the experience of the NIOSH Construction Program with two recent program planning initiatives intended to improve the program: (a) an independent external review of work over the past decade and (b) the development of strategic goals organized into a QUOTATION_MARKNational Construction AgendaQUOTATION_MARK to guide a decade of future work. These goals, developed with input from construction industry stakeholders and researchers, are a part of the NIOSH National Occupational Research Agenda (NORA) initiative. The NORA goals are intended to provide an ambitious set of goals for all construction stakeholders to work together on. Both efforts relate to insuring the relevance and impact of research, reflecting an emerging policy perspective that research programs should be judged not just by the quality and quantity of science produced, but by the industry impact and tangible benefit resulting from the research. This paper describes how views on research planning have evolved to incorporate lessons learned about how research leads to improved safety and health for workers. It also describes the process used to develop the goals and the resulting strategic and intermediate goals that comprise the National Construction Agenda. JF - Journal of Safety Research AU - Gillen, Matt AD - The National Institute for Occupational Safety and Health Office of Construction Safety and Health, 395 E Street, SW, Washington, DC 20201, mgillen@cdc.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 289 EP - 299 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 3 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - USA KW - Reviews KW - Occupational safety KW - stakeholders KW - Construction industry KW - Research programs KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754880179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=The+NIOSH+Construction+Program%3A+Research+to+practice%2C+impact%2C+and+developing+a+National+Construction+Agenda&rft.au=Gillen%2C+Matt&rft.aulast=Gillen&rft.aufirst=Matt&rft.date=2010-06-01&rft.volume=41&rft.issue=3&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Reviews; Occupational safety; stakeholders; Research programs; Construction industry; USA DO - http://dx.doi.org/10.1016/j.jsr.2010.04.002 ER - TY - JOUR T1 - Evaluation of guardrail systems for preventing falls through roof and floor holes AN - 754879959; 13398054 AB - Introduction - Fall-related occupational injuries and fatalities are serious problems in the U.S. construction industry, especially incidents related to unguarded holes. The National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV conducted a project to evaluate the effectiveness of guardrail systems to prevent falls through roof and floor holes. Methods - Two commercial edge-protection products were evaluated when used as perimeter guarding around a roof hole. Installations of the commercial products were compared to job-built guardrails constructed of 2 super(") x 4 super(") construction-grade lumber. Occupational Safety and Health Administration (OSHA) regulations require that "a force of at least 200 pounds" must be supported by the top rail of a guardrail system "in any outward or downward direction at any point along the top edge." A laboratory testing system was developed to evaluate this requirement. A dynamic 200-lb force was generated against the top rail using a weighted manikin mounted on a hinged steel frame. Nine construction workers, who served as test subjects, each built five different guardrail configurations. Results - All 45 configurations met the 200-lb OSHA requirement. Installation time for one commercial product was 32% quicker than the job-built configuration (25.6 min vs. 37.9 min). Impact on Industry - This study: (a) indicates that the two edge-protection products can be used as perimeter guarding; (b) highlights the importance of using proper materials and fasteners to construct guardrails to protect workers from falling into unguarded roof and floor holes; and (c) discusses an overall-strength-testing methodology that can be used by fall-protection researchers. JF - Journal of Safety Research AU - Bobick, Thomas G AU - McKenzie, E A AU - Kau, Tsui-Ying AD - Research Safety Engineer, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV 26505, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 203 EP - 211 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 3 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - Federal regulations KW - Laboratory testing KW - Occupational safety KW - lumber KW - safety regulations KW - Steel KW - Protective equipment KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754879959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Evaluation+of+guardrail+systems+for+preventing+falls+through+roof+and+floor+holes&rft.au=Bobick%2C+Thomas+G%3BMcKenzie%2C+E+A%3BKau%2C+Tsui-Ying&rft.aulast=Bobick&rft.aufirst=Thomas&rft.date=2010-06-01&rft.volume=41&rft.issue=3&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Mortality; Federal regulations; Laboratory testing; Occupational safety; lumber; safety regulations; Steel; Protective equipment; Construction industry; USA DO - http://dx.doi.org/10.1016/j.jsr.2010.02.008 ER - TY - JOUR T1 - Effectiveness of a worker-worn electric-field sensor to detect power-line proximity and electrical-contact AN - 754879905; 13398057 AB - Problem - Construction workers suffer the most electrocutions among all industries. Currently, there are no electrical contact warning devices on the market to protect workers. This paper proposes a worker-worn electric-field sensor. As the worker is in proximity to, or in contact with, a live power-circuit, the sensor sets off an audible/visual warning alarm. The sensor also has the potential to wirelessly trip a wireless-capable circuit breaker, and to trigger a wireless transmitter to notify emergency response of an electrical contact. Methods - An experiment was conducted to measure electric-field variation on simulated human-wrists (10 defrosted hog-legs) in various proximities and in electrical-contact to a simulated power-circuit. The purpose of these tests was to determine the feasibility of developing a worker-worn electric-field detection sensor for use in protecting workers from contact with energized electrical conductors. Results - This study observed a significant electric-field-magnitude increase as a hog-leg approaches the live-circuit, and the distinct electric-field-magnitude jump as the leg contacts with the live-circuit. The observation indicates that this sensor can be an effective device to warn the workers of electrical hazards. Additionally, the sensor has the potential to wirelessly trip a wireless-capable circuit-breaker and trigger a wireless transmitter (such as a cell phone) to notify an emergency response. The prompt notification prevents the worker from further injury caused by postponed medical-care. Impact on Industry - Widespread use of this sensor could lower electrocution and electrically related injury rates in the construction industry. JF - Journal of Safety Research AU - Zeng, Shengke AU - Powers, John R AU - Newbraugh, Bradley H AD - Division of Safety Research, National Institute for Occupational Safety and Health, szeng@cdc.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 229 EP - 239 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 3 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - Feasibility studies KW - cellular telephones KW - Sensors KW - Injuries KW - Emergency preparedness KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754879905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Effectiveness+of+a+worker-worn+electric-field+sensor+to+detect+power-line+proximity+and+electrical-contact&rft.au=Zeng%2C+Shengke%3BPowers%2C+John+R%3BNewbraugh%2C+Bradley+H&rft.aulast=Zeng&rft.aufirst=Shengke&rft.date=2010-06-01&rft.volume=41&rft.issue=3&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.02.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Feasibility studies; cellular telephones; Injuries; Sensors; Emergency preparedness; Construction industry DO - http://dx.doi.org/10.1016/j.jsr.2010.02.011 ER - TY - JOUR T1 - Newspaper Reports: A Source of Surveillance for Burns among Women in Pakistan AN - 754139711; 201022644 AB - Background: Our study attempts to describe the demographics, characteristics of victims and perpetrators, and circumstances leading to burn events among females in Pakistan. Methods: Human Rights Commission of Pakistan (HRCP) systematically collected data on burns among women using newspaper reports from January 2004 till December 2005. We analyzed the aggregated data and estimated burn rates. Results: A total of 222 burn events were reported from 2004 to 2005; complete data were not available for all variables. Adults (18 years) constituted 74% (91/123) of cases with 95% (121/127) being married. Most burns were caused by bursting of stoves (34%; 64/189) or victims set-on fire (33%; n = 63/189). Burns using acids accounted for 13% (25/189). Husbands (52%; 51/98) and in-laws (23%; 23/98) were the perpetrators in known burn events. Burns were classified as accidental in half of cases (51%; 97/189) and related to domestic issues in a quarter (25%; 47/189). There were 49% of (92/189) burns that were reported as intentional. The mean annual rate of burns among women (1564 years of age) was found to be 33 per 100 000. Conclusion: Newspaper reports are good source of surveillance when information is otherwise limited. Majority of burns (51%) were classified as accidental while 49% were reported as intentional, though there is a limitation in the accuracy of reported accidental events. There is a dire need for systematic data collection and devising preventive strategies for this important public health problem that remains largely neglected in Pakistan. Adapted from the source document. JF - Journal of Public Health AU - Nasrullah, Muazzam AU - Muazzam, Sana AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV E-mail: snasrullah@cdc.gov, mnasrullah@hsc.wvu.edu Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 245 EP - 249 PB - Oxford University Press VL - 32 IS - 2 SN - 1741-3842, 1741-3842 KW - burns, cultural practices, dowry, gender, Pakistan, stove, violence KW - Newspapers KW - Burns KW - Pakistan KW - Women KW - Perpetrators KW - Surveillance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754139711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Newspaper+Reports%3A+A+Source+of+Surveillance+for+Burns+among+Women+in+Pakistan&rft.au=Nasrullah%2C+Muazzam%3BMuazzam%2C+Sana&rft.aulast=Nasrullah&rft.aufirst=Muazzam&rft.date=2010-06-01&rft.volume=32&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdp102 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Burns; Pakistan; Women; Newspapers; Surveillance; Perpetrators DO - http://dx.doi.org/10.1093/pubmed/fdp102 ER - TY - JOUR T1 - What Level of On-Call Cover Is Required to Allow Trainees to Meet Minimum Faculty Requirements? AN - 754137059; 201021833 AB - Background: We investigated whether trainees out-of-hours experience in Wales is sufficient to allow them to meet Faculty training requirements. We also determined how much time on call, covering what population, allows trainees to meet these requirements. Methods: Using Welsh on-call audit data, we inferred the number of calls that trainees would receive during training and compared this with requirements for on-call experience. We generalized the analysis to examine the effect of changes in the population size covered and the length of time on call on the likelihood of trainees meeting minimum requirements. Results: Trainees in Wales can expect to achieve most on-call faculty requirements. However, the expected number of contacts with the Health Protection Agency, 0.95 [95% confidence interval (CI): 0.0245.281], and Environmental Health, 1.90 (95% CI: 0.2306.848), imply that trainees may have difficulty achieving requirement 2.4. For different requirements at a set population size, widely disparate lengths of time are necessary to be 95% certain of achievement. Conclusions: Most on-call requirements can be readily achieved in Wales, but contact with other professional groups (requirement 2.4) cannot be guaranteed. Further analysis suggests that requirement 2.4 is unlikely to be achieved except at unrealistic times on the on-call rota covering unrealistic populations. Adapted from the source document. JF - Journal of Public Health AU - King, W H AU - Mason, B AD - Department of Public Health, National Public Health Service for Wales, Pontypool, Torfaen, UK william.king@nphs.wales.nhs.uk Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 178 EP - 183 PB - Oxford University Press VL - 32 IS - 2 SN - 1741-3842, 1741-3842 KW - education, employment and skills KW - Trainees KW - Health KW - Wales KW - Professors KW - On call KW - Confidence intervals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754137059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=What+Level+of+On-Call+Cover+Is+Required+to+Allow+Trainees+to+Meet+Minimum+Faculty+Requirements%3F&rft.au=King%2C+W+H%3BMason%2C+B&rft.aulast=King&rft.aufirst=W&rft.date=2010-06-01&rft.volume=32&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdq012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Trainees; Professors; Wales; On call; Confidence intervals; Health DO - http://dx.doi.org/10.1093/pubmed/fdq012 ER - TY - BOOK T1 - The Idea of Order: Transforming Research Collections for 21st Century Scholarship AN - 754077963; 2010-564697 AB - The Idea of Order explores the transition from an analog to a digital environment for knowledge access, preservation, and reconstitution, and the implications of this transition for managing research collections. The volume comprises three reports. The first, "Can a New Research Library be All-Digital?" by Lisa Spiro and Geneva Henry, explores the degree to which a new research library can eschew print. The second, "On the Cost of Keeping a Book," by Paul Courant and Matthew "Buzzy" Nielsen, argues that from the perspective of long-term storage, digital surrogates offer a considerable cost savings over print-based libraries. The final report, "Ghostlier Demarcations," examines how well large text databases being created by Google Books and other mass-digitization efforts meet the needs of scholars, and the larger implications of these projects for research, teaching, and publishing. Tables, Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), Jun 2010, 130 pp. AU - Courant, Paul N AU - Henry, Charles AU - Henry, Geneva AU - Nielsen, Mathew "Buzzy" AU - Schonfeld, Roger C AU - Smith, Kathlin AU - Spiro, Lisa Y1 - 2010/06// PY - 2010 DA - June 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) SN - 9781932326352 KW - Education and education policy - Libraries KW - Media - Print media and publishing KW - Social conditions and policy - History KW - Storage KW - Libraries KW - Books KW - Archives KW - Digital libraries KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754077963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Courant%2C+Paul+N%3BHenry%2C+Charles%3BHenry%2C+Geneva%3BNielsen%2C+Mathew+%22Buzzy%22%3BSchonfeld%2C+Roger+C%3BSmith%2C+Kathlin%3BSpiro%2C+Lisa&rft.aulast=Courant&rft.aufirst=Paul&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=9781932326352&rft.btitle=The+Idea+of+Order%3A+Transforming+Research+Collections+for+21st+Century+Scholarship&rft.title=The+Idea+of+Order%3A+Transforming+Research+Collections+for+21st+Century+Scholarship&rft.issn=&rft_id=info:doi/ L2 - http://www.clir.org/pubs/reports/pub147/pub147.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-08-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - SuppNotes - CLIR Publication No. 147 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Late HIV diagnosis in Houston/Harris County, Texas, 2000-2007 AN - 753838159; 3997373 AB - This cross-sectional study aimed to evaluate the prevalence and predictive factors associated with late HIV diagnoses in Houston, Texas using surveillance data. Study subjects were Houston/Harris County residents, 13 years or older, diagnosed with HIV and reported to the Houston Department of Health and Human Services. Late HIV diagnosis was defined as an AIDS diagnosis within three months of an HIV diagnosis. Logistic regression was used to investigate the association between late HIV diagnoses and predictive factors. We found 31% of the study population had late HIV diagnoses. The Hispanic population, men, older individuals, heterosexuals, and those diagnosed in private facilities were more likely to receive late HIV diagnoses. Sensitivity analysis was conducted to evaluate the effect of time from HIV to AIDS diagnosis on the prevalence of a late diagnosis, and on the predictors of late diagnosis. The sensitivity analysis showed time affects prevalence, but not the odds ratios of the risk factors for late diagnosis. This finding suggests HIV prevention programs should specifically target these populations at risk for late HIV diagnosis to encourage frequent HIV testing. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Yang, Biru AU - Chan, Shirley AU - Mohammad, Naqi AU - Meyer, Jeffrey AU - Risser, Jan AU - Chronister, Karen AU - Wolverton, Marcia AU - Arafat, Raouf AU - Hwang, Lu-yu AD - University of Texas ; Houston Department of Health and Human Services Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 766 EP - 774 VL - 22 IS - 6 SN - 0954-0121, 0954-0121 KW - Sociology KW - U.S.A. KW - Prevention KW - AIDS KW - Texas KW - HIV KW - Health promotion KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753838159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Late+HIV+diagnosis+in+Houston%2FHarris+County%2C+Texas%2C+2000-2007&rft.au=Yang%2C+Biru%3BChan%2C+Shirley%3BMohammad%2C+Naqi%3BMeyer%2C+Jeffrey%3BRisser%2C+Jan%3BChronister%2C+Karen%3BWolverton%2C+Marcia%3BArafat%2C+Raouf%3BHwang%2C+Lu-yu&rft.aulast=Yang&rft.aufirst=Biru&rft.date=2010-06-01&rft.volume=22&rft.issue=6&rft.spage=766&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120903431348 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 482 3617 6220; 10072; 10449 5772; 5790 5772; 419 433 293 14 DO - http://dx.doi.org/10.1080/09540120903431348 ER - TY - JOUR T1 - Comparison of Three Anthrax Toxin Neutralization Assays AN - 746304260; 13055767 AB - Different types of anthrax toxin neutralization assays have been utilized to measure the antibody levels elicited by anthrax vaccines in both nonclinical and clinical studies. In the present study, we sought to determine whether three commonly used toxin neutralization assays-J774A.1 cell-, RAW 264.7 cell-, and CHO cell-based assays-yield comparable estimates of neutralization activities for sera obtained after vaccination with anthrax vaccines composed of recombinant protective antigen (rPA). In order to compare the assays, sera were assayed alongside a common reference serum sample and the neutralization titers were expressed relative to the titer for the reference sample in each assay. Analysis of sera from rabbits immunized with multiple doses of the rPA vaccine showed that for later bleeds, the quantitative agreement between the assays was good; however, for early bleeds, some heterogeneity in relative neutralization estimates was observed. Analysis of serum samples from rabbits, nonhuman primates, and humans immunized with the rPA vaccine showed that the relative neutralization estimates obtained in the different assays agreed to various extents, depending on the species of origin of the sera examined. We identified differences in the magnitudes of the Fc receptor-mediated neutralization associated with the J774A.1 cell- and RAW 264.7 cell-based assays, which may account for some of the species dependence of the assays. The differences in the relative neutralization estimates among the assays were relatively small and were always less than 2.5-fold. However, because toxin neutralization assays will likely be used to establish the efficacies of new anthrax vaccines, our findings should be considered when assay outputs are interpreted. JF - Clinical and Vaccine Immunology AU - Ngundi, Miriam M AU - Meade, Bruce D AU - Lin, Tsai-Lien AU - Tang, Wei-Jen AU - Burns, Drusilla L AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, drusilla.burns@fda.hhs.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 895 EP - 903 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 6 SN - 1556-679X, 1556-679X KW - Toxicology Abstracts; Immunology Abstracts KW - Fc KW - Antibodies KW - protective antigen KW - Anthrax KW - Vaccines KW - Primates KW - Toxins KW - F 06905:Vaccines KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746304260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Comparison+of+Three+Anthrax+Toxin+Neutralization+Assays&rft.au=Ngundi%2C+Miriam+M%3BMeade%2C+Bruce+D%3BLin%2C+Tsai-Lien%3BTang%2C+Wei-Jen%3BBurns%2C+Drusilla+L&rft.aulast=Ngundi&rft.aufirst=Miriam&rft.date=2010-06-01&rft.volume=17&rft.issue=6&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00513-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 36 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fc; Antibodies; protective antigen; Anthrax; Vaccines; Toxins; Primates DO - http://dx.doi.org/10.1128/CVI.00513-09 ER - TY - JOUR T1 - Collaboration, cooperation, and engagement across agencies AN - 746235807; 13183866 AB - Staff throughout USDA and FDA have been collaborating for years on various projects. However, it has recently been brought to the attention of policy-makers and administration officials that this collaboration is not well known. The presentation will focus on highlighting some of the history of past collaborative efforts, current activities and a new emphasis on engaging of other Federal and State agencies throughout government specifically related to the work FDA is undertaking on developing a produce safety rule. JF - Phytopathology AU - Skelton, L L AD - FDA, CFSAN, Office of Food Safety, Produce Safety Staff, College Park, MD, USA Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 1 VL - 100 IS - 6 SN - 0031-949X, 0031-949X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Cooperation KW - A 01360:Plant Diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746235807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Phytopathology&rft.atitle=Collaboration%2C+cooperation%2C+and+engagement+across+agencies&rft.au=Skelton%2C+L+L&rft.aulast=Skelton&rft.aufirst=L&rft.date=2010-06-01&rft.volume=100&rft.issue=6&rft.spage=S155&rft.isbn=&rft.btitle=&rft.title=Phytopathology&rft.issn=0031949X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Cooperation ER - TY - JOUR T1 - FDA Adverse Event Problem Codes: Standardizing the Classification of Device and Patient Problems Associated with Medical Device Use AN - 746234332; 13194361 AB - The broad array of medical devices and the potential for device failures, malfunctions, and other adverse events associated with each device creates a challenge for public health device surveillance programs. Coding reported events by type of device problem provides one method for identifying a potential signal of a larger device issue. The Food and Drug Administration's (FDA) Center for Devices and Radiological Health (CDRH) Event Problem Codes that are used to report adverse events previously lacked a structured set of controls for code development and maintenance. Over time this led to inconsistent, ambiguous, and duplicative concepts being added to the code set on an ad-hoc basis. Recognizing the limitation of its coding system the FDA set out to update the system to improve its usefulness within FDA and as a basis of a global standard to identify important patient and device outcomes throughout the medical community. Methods: In 2004, FDA and the National Cancer Institute (NCI) signed a Memorandum of Understanding (MOU) whereby NCI agreed to provide terminology development and maintenance services to all FDA Centers. Under this MOU, CDRH's Office of Surveillance and Biometrics (OSB) convened a cross-Center workgroup and collaborated with staff at NCI Enterprise Vocabulary Service (EVS) to streamline the Patient and Device Problem Codes and integrate them into the NCI Thesaurus and Meta-Thesaurus. This initiative included many enhancements to the Event Problem Codes aimed at improving code selection as well as improving adverse event report analysis. Limitations & Recommendations: Staff resources, database concerns, and limited collaboration with external groups in the initial phases of the project are discussed. Conclusions: Adverse events associated with medical device use can be better understood when they are reported using a consistent and well-defined code set. This FDA initiative was an attempt to improve the structure and add control mechanisms to an existing code set, improve analysis tools that will better identify device safety trends, and improve the ability to prevent or mitigate effects of adverse events associated with medical device use. JF - Biomedical Instrumentation & Technology AU - Reed, T L AU - Kaufman-Rivi, D AD - FDA's Center for Devices and Radiological Health (CDRH), Office of Surveillance and Biometrics (OSB), terrie.reed@fda.hhs.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 248 EP - 255 VL - 44 IS - 3 SN - 0899-8205, 0899-8205 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Classification KW - Drug development KW - Biometrics KW - Public health KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746234332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Instrumentation+%26+Technology&rft.atitle=FDA+Adverse+Event+Problem+Codes%3A+Standardizing+the+Classification+of+Device+and+Patient+Problems+Associated+with+Medical+Device+Use&rft.au=Reed%2C+T+L%3BKaufman-Rivi%2C+D&rft.aulast=Reed&rft.aufirst=T&rft.date=2010-06-01&rft.volume=44&rft.issue=3&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Biomedical+Instrumentation+%26+Technology&rft.issn=08998205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Databases; Classification; Drug development; Biometrics; Public health ER - TY - BOOK T1 - Coal Truck Driver Dies in Rollover After Tire on Trailer Fails AN - 746164725; 13109881 AB - In the fall of 2006, a twenty-three year old male tractor-trailer driver who was hauling coal, died when a rear outer tire on the trailer failed. After the tire failed, the trailer slipped off the right side of the road, overturned, and went over an embankment. The trailer remained attached to the tractor as both went over the embankment, flipping the entire unit upside down. A witness called emergency medical services who arrived and called the county coroner. The coroner arrived and declared the driver dead at the scene. It was determined by Kentucky State Police that the driver was not wearing a seat belt at the time of the incident. Speed at the time of the crash was not listed in the investigation report. Toxicology tests detected tramadol, oxycodone, and hydrocodone in the driver's system at the time of the crash. To prevent future occurrences of similar incidents, the following recommendations have been made: Recommendation No. 1: Employers should require drivers to perform pre-trip and post-trip inspections on the tractor and trailer prior to operation. Recommendation No. 2: Employers should require the use of seat belts while operating a commercial vehicle. Recommendation No. 3: Companies should provide professional training for company truck drivers. Recommendation No. 4: Stabilizer and sensory systems should be mandatory equipment on all commercial vehicles. Recommendation No. 5: Comprehensive expanded new-hire prescreening and after-hire random drug/ alcohol testing policies should be implemented and enforced for substance abuse. JF - Coal Truck Driver Dies in Rollover After Tire on Trailer Fails Y1 - 2010/06// PY - 2010 DA - Jun 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - embankments KW - Motor vehicles KW - Coal KW - inspection KW - substance abuse KW - police KW - Trucks KW - Drugs KW - rollover KW - Toxicology KW - seat belts KW - Agricultural equipment KW - Alcohol KW - Training KW - Protective equipment KW - USA, Kentucky KW - Tires KW - emergency medical services KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Coal+Truck+Driver+Dies+in+Rollover+After+Tire+on+Trailer+Fails&rft.title=Coal+Truck+Driver+Dies+in+Rollover+After+Tire+on+Trailer+Fails&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Equipment Operator Killed by a Lock Ring Propelled from a Multi-piece Rim Wheel AN - 746163982; 13109880 AB - In December 2007, a male equipment operator was fatally injured by a metal lock ring propelled from a multi-piece wheel tire assembly he was inflating. The victim was employed by an excavating and snow removal company. At the time of the incident, he and a co-worker were getting their loaders ready to remove snow from a shopping mall parking lot. New York State Fatality Assessment and Control Evaluation (NY FACE) investigators concluded that to help prevent similar incidents from occurring in the future, employers should: develop, implement and enforce a standard operating procedure (SOP) for inflating multi-piece rim wheels that requires that only trained workers service or inflate multi-piece rim wheels ensure that all equipment operators receive training and demonstrate competency on the SOP as well as the safety hazards and precautions associated with inflating a multi-piece rim wheel; and provide an air hose that has an in-line pressure gauge and sufficient hose between the in-line pressure gauge and the clip-on chuck to allow workers to stay outside the trajectory of wheel parts when inflating a tire. JF - Equipment Operator Killed by a Lock Ring Propelled from a Multi-piece Rim Wheel. [np]. Jun 2010. AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Metals KW - Mortality KW - Snow KW - Training KW - USA, New York KW - Recreation areas KW - Tires KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Equipment+Operator+Killed+by+a+Lock+Ring+Propelled+from+a+Multi-piece+Rim+Wheel&rft.title=Equipment+Operator+Killed+by+a+Lock+Ring+Propelled+from+a+Multi-piece+Rim+Wheel&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Driver of a Semi-Tractor Pulling Twin Trailers Fatally Injured in Single Vehicle Crash AN - 746163729; 13109879 AB - In the spring of 2008, a 40-year-old tractor-trailer driver died after his vehicle left the interstate highway, crashed, and was engulfed in flames. The tractor drifted over the fog line and rumble strip onto the right shoulder, began to skid and left the highway. The tractor slid through the grass beside the roadway, struck a concrete culvert, sideswiped a small tree and then hit a large tree head-on. The tractor and trailers then skidded back down the embankment toward the highway where the entire unit came to rest. The tractor and lead trailer overturned onto the driver's side. The second (rear) trailer uncoupled from the first trailer but remained upright and attached by safety chains. Emergency medical services were contacted. Upon arrival, EMS found the entire unit engulfed in flames. The coroner was contacted, and upon his arrival, declared the driver dead at the scene. To prevent future occurrences of similar incidents, the following recommendations have been made: Recommendation No. 1: Commercial tractor-trailer drivers should be trained to recognize signs of fatigue and when to seek appropriate rest areas. Recommendation No. 2: Companies should provide new and refresher commercial driver safety training for company drivers addressing driver distraction and including defensive driving techniques. Recommendation No. 3: Vehicle stabilizer and sensory systems should be mandatory equipment on all commercial vehicles. Recommendation No. 4: Log books and other important driver records should be stored in a fireproof container in the cab. JF - Driver of a Semi-Tractor Pulling Twin Trailers Fatally Injured in Single Vehicle Crash. [np]. Jun 2010. AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Containers KW - embankments KW - Grasses KW - Trees KW - Concrete KW - fatigue KW - Lead KW - Highways KW - Agricultural equipment KW - Training KW - Fog KW - Books KW - emergency medical services KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Driver+of+a+Semi-Tractor+Pulling+Twin+Trailers+Fatally+Injured+in+Single+Vehicle+Crash&rft.title=Driver+of+a+Semi-Tractor+Pulling+Twin+Trailers+Fatally+Injured+in+Single+Vehicle+Crash&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Trackman Dies after Being Caught Between a People Mover and a Clip Applicator while Replacing Railroad Ties- Massachusetts AN - 746163724; 13109882 AB - On June 22, 2006, a 36-year-old male trackman was fatally injured while working with a tie gang to replace railroad ties. The victim's main task as a trackman during this project was to retrieve clips from a clip bag located at the rear of the clip applicator (clipper), and insert the clips into the railroad track's bracket and tie. The victim was standing in the track behind the clipper by the clip bag when a people mover (bus) that was being operated by a co-worker struck the victim crushing him against the clipper. Co-workers radioed the dispatcher who then placed a call for Emergency Medical Services (EMS). EMS responded to the incident site within minutes along with the transit, municipal, and state police. The victim was transported to a local hospital where he was pronounced dead. The Massachusetts FACE Program concluded that to prevent similar occurrences in the future, railroad transportation companies/agencies should: Ensure that routinely accessed items, such as clip bags, are not located where roadway workers have to repeatedly foul tracks (position themselves in between or near) to access them; Strictly enforce the required ten foot clearance between equipment as well as other regulations established to protect workers; Inspect and evaluate all purchased or acquired equipment, especially equipment altered by another entity, to ensure it is safe to operate prior to placing It in operation; and Conduct a routine job safety analysis (JSA) for each piece of equipment and the tasks the equipment will be involved in to ensure worker safety. JF - Trackman Dies after Being Caught Between a People Mover and a Clip Applicator while Replacing Railroad Ties- Massachusetts. [np]. Jun 2010. AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - USA, Massachusetts KW - gang activity KW - Transportation KW - police KW - Railroads KW - Highways KW - emergency medical services KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Trackman+Dies+after+Being+Caught+Between+a+People+Mover+and+a+Clip+Applicator+while+Replacing+Railroad+Ties-+Massachusetts&rft.title=Trackman+Dies+after+Being+Caught+Between+a+People+Mover+and+a+Clip+Applicator+while+Replacing+Railroad+Ties-+Massachusetts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Machine Operator in a Plastic Recycling Facility Dies After Being Caught in a Bale Breaker Machine AN - 746163721; 13109878 AB - A machine operator died after being caught in the blades of a plastic bottle bale breaker. The victim was attempting to kick plastic bottles into the blades of the bale breaker when his leg caught on the rotating blades of the bale breaker. There were no safety interlocks or protective guarding to prevent workers from entering the conveyor area while the machine was running. The CA/FACE investigator determined that, in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP) should: Collaborate with bale breaker manufacturers on the design and installation of safety features to keep employees away from moving parts. JF - Machine Operator in a Plastic Recycling Facility Dies After Being Caught in a Bale Breaker Machine. [np]. Jun 2010. AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - safety engineering KW - Injuries KW - prevention KW - Recycling KW - Waste management KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Machine+Operator+in+a+Plastic+Recycling+Facility+Dies+After+Being+Caught+in+a+Bale+Breaker+Machine&rft.title=Machine+Operator+in+a+Plastic+Recycling+Facility+Dies+After+Being+Caught+in+a+Bale+Breaker+Machine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Chemical risk assessment and uncertainty associated with extrapolation across exposure duration AN - 746002769; 13030635 AB - The Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on priority substances in which available epidemiologic and toxicologic data are reviewed, summarized, and interpreted. When adequate data are available, ATSDR derives health guidance values called minimal risk levels (MRLs) for acute, intermediate, and chronic durations of exposure for oral and inhalation routes of exposure. The MRLs are generally derived by use of the no-observed-adverse-effect level (NOAEL) or the lowest-observed-adverse-effect level/uncertainty factor (LOAEL/UF) approach. The UF usually employed are for LOAEL-to-NOAEL extrapolation, animal to -human extrapolation, and inter-human variability. These health guidance values are intended to serve as screening tools for health assessors and other responders to identify contaminants of concern and potential health effects in the community at hazardous waste sites and during unplanned releases. When guidance values are not available for a specific exposure scenario because of a lack of chronic data, extrapolation across exposure durations may be made. For example, chronic guidance values may be derived from subchronic data by applying an additional uncertainty factor of 10 for extrapolation to chronic exposure duration. In this paper, we analyzed the ratio of chemical-specific LOAELs from acute to intermediate and from intermediate to chronic durations for oral and inhalation exposure routes. In addition, we investigated the impact of chemical structure and chemical structure activity relationship on validation of predictions across exposure durations. JF - Regulatory Toxicology and Pharmacology AU - Pohl, H R AU - Chou, C-HSJ AU - Ruiz, P AU - Holler, J S AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA, hpohl@cdc.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 18 EP - 23 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 57 IS - 1 SN - 0273-2300, 0273-2300 KW - Pollution Abstracts; Environment Abstracts; Risk Abstracts; Toxicology Abstracts KW - Chronic exposure KW - Inhalation KW - Data processing KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health KW - P 4000:WASTE MANAGEMENT KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746002769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Chemical+risk+assessment+and+uncertainty+associated+with+extrapolation+across+exposure+duration&rft.au=Pohl%2C+H+R%3BChou%2C+C-HSJ%3BRuiz%2C+P%3BHoller%2C+J+S&rft.aulast=Pohl&rft.aufirst=H&rft.date=2010-06-01&rft.volume=57&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2009.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Data processing; Inhalation DO - http://dx.doi.org/10.1016/j.yrtph.2009.11.007 ER - TY - JOUR T1 - Do Medicare Advantage enrollees tend to be admitted to hospitals with better or worse outcomes compared with fee-for-service enrollees? AN - 745974196; 12598200 AB - The hospitals selected by or for Medicare beneficiaries might depend on whether the patient is enrolled in a Medicare Advantage (MA) plan. A theoretical model of profit maximization by MA plans takes into account the tradeoffs of consumer preferences for annual premium versus outcomes of care in the hospital and other attributes of the plan. Hospital discharge databases for 13 states in 2006, maintained by the Agency for Healthcare Research and Quality, are the main source of data. Risk-adjusted mortality rates are available for all non-maternity adult patients in each of 15 clinical categories in about 1,500 hospitals. All-adult postoperative safety event rates covering 9 categories of events are calculated for surgical cases in about 900 hospitals. Instrumental variables are used to address potential endogeneity of the choice of a MA plan. The key findings are these: enrollees in MA plans tend to be treated in hospitals with lower resource cost and higher risk-adjusted mortality compared to Fee-for-Service (FFS) enrollees. The risk-adjusted mortality measure is about 1.5percentage points higher for MA plan enrollees than the overall mean of 4%. However, the rate of safety events in surgical patients favors MA plan enrollees-the rate is 1percentage point below the average of 3.5%. These discrepant results are noteworthy and are plausibly due to greater discretion by the health plan in approving patients for elective surgery and as well as selecting hospitals for surgical patients. Emergency patients are generally excluded for the safety outcome measures. In addition, the current mortality measures may not adequately represent all surgical patients. Such caveats should be prominently highlighted when presenting comparative data. With that proviso, the study justifies informing Medicare beneficiaries about the mortality and safety outcome measures for hospitals being used by a MA plan compared to hospitals used by FFS enrollees. JF - International Journal of Health Care Finance and Economics AU - Friedman, Bernard AU - Jiang, HJoanna AD - Agency for Healthcare Research and Quality (AHRQ), 540 Gaither Road, Rockville, MD, 20850, USA Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 171 EP - 185 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 10 IS - 2 SN - 1389-6563, 1389-6563 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745974196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Health+Care+Finance+and+Economics&rft.atitle=Do+Medicare+Advantage+enrollees+tend+to+be+admitted+to+hospitals+with+better+or+worse+outcomes+compared+with+fee-for-service+enrollees%3F&rft.au=Friedman%2C+Bernard%3BJiang%2C+HJoanna&rft.aulast=Friedman&rft.aufirst=Bernard&rft.date=2010-06-01&rft.volume=10&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Health+Care+Finance+and+Economics&rft.issn=13896563&rft_id=info:doi/10.1007%2Fs10754-010-9076-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1007/s10754-010-9076-0 ER - TY - JOUR T1 - First U.S. report of shellfish harvesting closures due to confirmed okadaic acid in Texas Gulf coast oysters AN - 745928930; 13026186 AB - Between March 7 and April 12, 2008, several bay systems on the east (Gulf of Mexico) coast of Texas, USA were closed to the harvesting of oysters (Crassostrea virginica) due to the presence of the DSP (Diarrheic Shellfish Poisoning) toxin okadaic acid in excess of the 20 mu g/100g tissue FDA regulatory guidance level. This was the first shellfish harvesting closure due to the confirmed presence of DSP toxins in US history. Light microscopic cell counts were performed on water samples collected from numerous sampling sites along the Texas Gulf coast where shellfish harvesting occurs. Ultra performance liquid chromatography, electrospray ionization, selected reaction monitoring, mass spectrometry (UPLC/ESI/SRM/MS) was used to detect DSP toxins in oysters. The closures were associated with an extensive bloom of the dinoflagellate Dinophysis cf. ovum. Only okadaic acid (OA) and OA acyl esters were found in shellfish tissues (max. OA eq. levels 47 mu g/100g tissue). OA was also confirmed in a bloom water sample. No illnesses were reported associated with this event. DSP toxins now add to a growing list of phycotoxins, which include those responsible for PSP (paralytic shellfish poisoning), NSP (neurotoxic shellfish poisoning), and ASP (amnesic shellfish poisoning) which must now be monitored for in US coastal waters where shellfish are harvested. JF - Toxicon AU - Deeds, Jonathan R AU - Wiles, Kirk AU - Heideman, Gary B AU - White, Kevin D AU - Abraham, Ann AD - US Food and Drug Administration Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 1138 EP - 1146 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 55 IS - 6 SN - 0041-0101, 0041-0101 KW - ASFA Aquaculture Abstracts; Pollution Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Algal blooms KW - Water sampling KW - Toxicants KW - Chromatographic techniques KW - Phytoplankton KW - Mass spectroscopy KW - Okadaic acid KW - ASW, USA, Texas KW - oysters KW - Dinoflagellates KW - Sampling KW - Amnesic shellfish poisoning KW - Paralytic shellfish poisoning KW - Coasts KW - Marine KW - Dinophysis KW - Shellfish fisheries KW - Biological poisons KW - Poisoning KW - ASW, USA, Gulf Coast KW - Toxicity KW - Esters KW - Coastal waters KW - Toxins KW - ASW, Mexico Gulf KW - Coastal zone KW - Liquid chromatography KW - harvesting KW - Neurotoxicity KW - Marine molluscs KW - Crassostrea virginica KW - Shellfish KW - Ionization KW - phycotoxins KW - Harvesting KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - X 24370:Natural Toxins KW - P 1000:MARINE POLLUTION KW - Q3 08588:Effects of Aquaculture on the Environment KW - Q1 08588:Effects of Aquaculture on the Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=First+U.S.+report+of+shellfish+harvesting+closures+due+to+confirmed+okadaic+acid+in+Texas+Gulf+coast+oysters&rft.au=Deeds%2C+Jonathan+R%3BWiles%2C+Kirk%3BHeideman%2C+Gary+B%3BWhite%2C+Kevin+D%3BAbraham%2C+Ann&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2010-06-01&rft.volume=55&rft.issue=6&rft.spage=1138&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2010.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Algal blooms; Shellfish fisheries; Toxicants; Chromatographic techniques; Biological poisons; Phytoplankton; Marine molluscs; Toxicity; Paralytic shellfish poisoning; Poisoning; Coastal waters; Esters; Toxins; Mass spectroscopy; Okadaic acid; Liquid chromatography; Neurotoxicity; Dinoflagellates; Sampling; Amnesic shellfish poisoning; Ionization; Harvesting; phycotoxins; Coasts; Coastal zone; oysters; Water sampling; harvesting; Shellfish; Dinophysis; Crassostrea virginica; ASW, Mexico Gulf; ASW, USA, Texas; ASW, USA, Gulf Coast; Marine DO - http://dx.doi.org/10.1016/j.toxicon.2010.01.003 ER - TY - JOUR T1 - Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study AN - 744615881; 12941712 AB - Objective: Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer. Methods: The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days)(exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders. Results: Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06-1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HR sub(highest tertile)=1.21; 95% CI=0.99-1.47) and lung (HR sub(middle tertile)=1.45; 95% CI=0.95-2.22) and leukemia (HR sub(middle tertile)=2.38; 95% CI=1.35-4.21) and non-Hodgkin's lymphoma (HR sub(middle tertile)=1.94; 95% CI=1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant. Conclusion: We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos. JF - Cancer Causes & Control AU - Bonner, Matthew R AU - Williams, Brent A AU - Rusiecki, Jennifer A AU - Blair, Aaron AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Dosemeci, Mustafa AU - Lubin, Jay AU - Sandler, Dale P AU - Alavanja, Michael CR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, mrbonner@buffalo.edu Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 871 EP - 877 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 6 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - USA, North Carolina KW - Organophosphates KW - Models KW - Non-Hodgkin's lymphoma KW - Leukemia KW - Insecticides KW - Carcinogenicity KW - Dose-response effects KW - Occupational exposure KW - Inventories KW - organophosphates KW - Cancer KW - Prostate cancer KW - USA, Iowa KW - Lung KW - Pesticides KW - Prostate KW - rodents KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Occupational+exposure+to+terbufos+and+the+incidence+of+cancer+in+the+Agricultural+Health+Study&rft.au=Bonner%2C+Matthew+R%3BWilliams%2C+Brent+A%3BRusiecki%2C+Jennifer+A%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BDosemeci%2C+Mustafa%3BLubin%2C+Jay%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+CR&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9514-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Inventories; organophosphates; Cancer; Models; Leukemia; Non-Hodgkin's lymphoma; Insecticides; Prostate cancer; Lung; Dose-response effects; Pesticides; Prostate; Occupational exposure; non-Hodgkin's lymphoma; Organophosphates; Carcinogenicity; rodents; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1007/s10552-010-9514-9 ER - TY - JOUR T1 - Risk of non-Hodgkin lymphoma and nitrate and nitrite from the diet in Connecticut women AN - 744615686; 12941715 AB - It has been estimated that 65,980 individuals were diagnosed with non-Hodgkin lymphoma (NHL) and 19,500 died from NHL in the United States in 2009. Although established risk factors such as immunodeficiency and viral infections may be responsible for a portion of the cases, the majority of NHL cases remain unexplained. Dietary nitrate and nitrite intake are exposures of particular interest for NHL risk as they are precursors in the endogenous formation of N-nitroso compounds, which cause lymphomas in animal studies. We investigated NHL risk overall and by histologic type in relation to dietary nitrate and nitrite intake in a population-based case-control study of 1,304 women in Connecticut. Nitrate and nitrite intake were assessed using a 120-item food frequency questionnaire. We found no association between risk of NHL overall and dietary nitrate and a slightly increased risk of NHL with higher dietary nitrite intake (highest vs. lowest intake quartile OR=1.4; 95% CI: 0.9-2.2). When we evaluated intake by subtype, a significant positive trend was observed for follicular lymphoma and nitrate (p-trend=0.04) and nitrite (p-trend<0.01) with an over twofold risk in the highest nitrite intake quartile (OR=2.3; 95% CI: 1.1-4.9). An increased risk in the highest quartile of nitrite intake was also observed for T-cell lymphoma (OR=3.4; 95% CI: 1.0-11.9). Animal products containing nitrite were more strongly associated with risk of follicular lymphoma; whereas, both animal and plant sources of nitrite were associated with elevated ORs for T-cell lymphoma. Our results confirm a previous finding for nitrite intake and NHL risk and highlight the importance of evaluating histologic type. We conclude that these results should be replicated in a larger study with data on drinking water as well as dietary sources of nitrate intake. JF - Cancer Causes & Control AU - Kilfoy, Briseis A AU - Ward, Mary H AU - Zheng, Tongzhang AU - Holford, Theodore R AU - Boyle, Peter AU - Zhao, Ping AU - Dai, Min AU - Leaderer, Brian AU - Zhang, Yawei AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, EPS, Room 8111, 6120 Executive Boulevard, Rockville, MD, 20852-7244, USA, kilfoyb@mail.nih.gov Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 889 EP - 896 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 21 IS - 6 SN - 0957-5243, 0957-5243 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Nitrate KW - USA, Connecticut KW - Food KW - Immunodeficiency KW - animal products KW - Infection KW - Risk factors KW - Nitrite KW - Diets KW - Inventories KW - Data processing KW - Nitrates KW - Cancer KW - N-Nitroso compounds KW - Nitrites KW - Females KW - T-cell lymphoma KW - Drinking water KW - lymphoma KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744615686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Risk+of+non-Hodgkin+lymphoma+and+nitrate+and+nitrite+from+the+diet+in+Connecticut+women&rft.au=Kilfoy%2C+Briseis+A%3BWard%2C+Mary+H%3BZheng%2C+Tongzhang%3BHolford%2C+Theodore+R%3BBoyle%2C+Peter%3BZhao%2C+Ping%3BDai%2C+Min%3BLeaderer%2C+Brian%3BZhang%2C+Yawei&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2010-06-01&rft.volume=21&rft.issue=6&rft.spage=889&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-010-9517-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Diets; Inventories; Nitrate; N-Nitroso compounds; Data processing; Food; Risk factors; Immunodeficiency; Nitrite; Infection; Drinking water; T-cell lymphoma; non-Hodgkin's lymphoma; Nitrates; Nitrites; Females; animal products; lymphoma; Cancer; USA, Connecticut DO - http://dx.doi.org/10.1007/s10552-010-9517-6 ER - TY - JOUR T1 - US Public Health Service Commissioned Corps Nurses: Responding in Times of National Need AN - 742726047; 201015686 AB - The US Public Health Service (PHS) is one of 7 uniformed services operating for the nation. Nurses form the largest category of personnel in the PHS and are integral members of teams identified to deploy in times of national need. PHS nurses serve 'in harm's way' to protect and defend the public health of the nation during national emergencies and disasters of great magnitude, such as 9/11, Hurricane Katrina, the H1N1 virus outbreak, and so forth. In this article, the authors discuss how active-duty Commissioned Corps nurses in the US PHS respond during times of national need. Military nurses may be asked to serve in war zones, participate in humanitarian missions, and care for military beneficiaries. By contrast, the role of nurses in the Commissioned Corps is to protect, defend, and advance the public health of the nation. PHS nurses are critical members of interdisciplinary health care teams organized to provide health care to diverse populations in the United States and abroad. Keywords: US Public Health Service; Emergency preparedness; Disaster response; Public health service nursing; Commissioned Corps. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Debisette, Annette Tyree AU - Martinelli, Angela M AU - Couig, Mary Pat AU - Braun, Michelle AD - US Public Health Service, Food and Drug Administration, Office of Regulatory Affairs, Division of Human Resource Development, 11919 Rockville Pike, Rockville, MD 20852, USA Annette.debisette@fda.hhs.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 123 EP - 135 PB - Elsevier Ltd, The Netherlands VL - 45 IS - 2 SN - 0029-6465, 0029-6465 KW - US Public Health Service Emergency preparedness Disaster response Public health service nursing Commissioned Corps KW - Emergency services KW - Public health care KW - Disaster management KW - Nurses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742726047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=US+Public+Health+Service+Commissioned+Corps+Nurses%3A+Responding+in+Times+of+National+Need&rft.au=Debisette%2C+Annette+Tyree%3BMartinelli%2C+Angela+M%3BCouig%2C+Mary+Pat%3BBraun%2C+Michelle&rft.aulast=Debisette&rft.aufirst=Annette&rft.date=2010-06-01&rft.volume=45&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2010.02.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Public health care; Nurses; Emergency services; Disaster management DO - http://dx.doi.org/10.1016/j.cnur.2010.02.003 ER - TY - JOUR T1 - Explaining Racial and Ethnic Differences in Antidepressant Use Among Adolescents AN - 742719549; 201016890 AB - We investigate the extent to which antidepressant use among adolescents varies across racial and ethnic subgroups. Using a representative sample of U.S. adolescents, we find that non-Hispanic White adolescents are over twice as likely as Hispanic adolescents, and over five times as likely as non-Hispanic Black adolescents to use antidepressants. Results from a decomposition analysis indicate that racial/ethnic differences in characteristics, including household income, parental education, health insurance, and having a usual source of care explain between one half and two thirds of the gap in antidepressant use between Hispanics and non-Hispanic Whites. In contrast, none of the gap between Whites and Blacks in antidepressant use is explained by differences in observed characteristics. Further analysis suggests that there are large racial/ethnic differences in the extent to which behavioral and mental health problems prompt antidepressant use and that this may, in part, account for the large differences across race/ethnicity observed in our study. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Kirby, James B AU - Hudson, Julie AU - Miller, G Edward AD - Agency for Healthcare Research and Quality, Rockville, MD jkirby@ahrq.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 342 EP - 363 PB - Sage Publications, Thousand Oaks CA VL - 67 IS - 3 SN - 1077-5587, 1077-5587 KW - adolescents antidepressant race and ethnicity KW - Ethnic differences KW - Racial differences KW - Depression KW - Antidepressant drugs KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742719549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Explaining+Racial+and+Ethnic+Differences+in+Antidepressant+Use+Among+Adolescents&rft.au=Kirby%2C+James+B%3BHudson%2C+Julie%3BMiller%2C+G+Edward&rft.aulast=Kirby&rft.aufirst=James&rft.date=2010-06-01&rft.volume=67&rft.issue=3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558709350884 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Antidepressant drugs; Adolescents; Racial differences; Ethnic differences; Depression DO - http://dx.doi.org/10.1177/1077558709350884 ER - TY - JOUR T1 - Ground Zero Recollections of US Public Health Service Nurses Deployed to New York City in September 2001 AN - 742717957; 201016916 AB - The events of September 11, 2001, set in motion the broadest emergency response ever conducted by the US Department of Health and Human Services. In this article, some of the nurses who deployed to New York City in the aftermath of that horrific attack on the United States offer their recollections of the events. Although Public Health Service Commissioned Corps (PHS CC) officers participated in deployments before 9/11, this particular deployment accelerated the transformation of the PHS CC, because people came to realize the tremendous potential of a uniformed service of 6,000 health care professionals. When not responding to emergencies, PHS CC nurses daily serve the mission of the PHS to protect, promote, and advance the health and safety of the nation. In times of crisis, the PHS CC nurses stand ready to deploy in support of those in need of medical assistance. Keywords: US Public Health Service; Emergency preparedness; September 11; World Trade Center; Disaster response; Public health service nursing. [Copyright Elsevier B.V.] JF - Nursing Clinics of North America AU - Knebel, Ann R AU - Martinelli, Angela M AU - Orsega, Susan AU - Doss, Thomas L AU - Balingit-Wines, Ana Marie AU - Konchan, Carol L AD - US Public Health Service Commissioned Corps (PHS CC), Office of Public Health and Science, US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201, USA ann.knebel@hhs.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 137 EP - 152 PB - Elsevier Ltd, The Netherlands VL - 45 IS - 2 SN - 0029-6465, 0029-6465 KW - US Public Health Service Emergency preparedness September 11 World Trade Center Disaster response Public health service nursing KW - Terrorism KW - Nursing KW - Nurses KW - Social services KW - Deployment KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742717957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nursing+Clinics+of+North+America&rft.atitle=Ground+Zero+Recollections+of+US+Public+Health+Service+Nurses+Deployed+to+New+York+City+in+September+2001&rft.au=Knebel%2C+Ann+R%3BMartinelli%2C+Angela+M%3BOrsega%2C+Susan%3BDoss%2C+Thomas+L%3BBalingit-Wines%2C+Ana+Marie%3BKonchan%2C+Carol+L&rft.aulast=Knebel&rft.aufirst=Ann&rft.date=2010-06-01&rft.volume=45&rft.issue=2&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Nursing+Clinics+of+North+America&rft.issn=00296465&rft_id=info:doi/10.1016%2Fj.cnur.2010.02.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Public health; Nurses; Terrorism; Deployment; Social services; Nursing DO - http://dx.doi.org/10.1016/j.cnur.2010.02.010 ER - TY - JOUR T1 - E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. AN - 733836817; 19839049 AB - The conversion of early stage tumors into invasive malignancies with an aggressive phenotype has been associated with the irreversible loss of E-cadherin expression. The loss of E-cadherin expression in human tumors, including breast cancer, has been attributed to promoter CpG island hypermethylation and direct inhibition by transcriptional repressors. Recent evidence demonstrates that up-regulation of E-cadherin by microRNA-200b (miR-200b) and miR-200c through direct targeting of transcriptional repressors of E-cadherin, ZEB1, and ZEB2, inhibits epithelial-to-mesenchymal transition (EMT), a crucial process in the tumor progression. We demonstrate that microRNA miR-200 family-mediated transcriptional up-regulation of E-cadherin in mesenchymal MDA-MB-231 and BT-549 cells is associated directly with translational repression of ZEB1 and indirectly with increased acetylation of histone H3 at the E-cadherin promoter. The increase in histone H3 acetylation may be attributed to the disruption of repressive complexes between ZEB1 and histone deacetylases and to the inhibition of SIRT1, a class III histone deacetylase. These events inhibit EMT and reactivate a less aggressive epithelial phenotype in cancer cells. Additionally, disruption of ZEB1-histone deacetylase repressor complexes and down-regulation of SIRT1 histone deacetylase up-regulate proapoptotic genes in the p53 apoptotic pathway resulting in the increased sensitivity of cancer cells to the chemotherapeutic agent doxorubicin. JF - International journal of cancer AU - Tryndyak, Volodymyr P AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 2575 EP - 2583 VL - 126 IS - 11 KW - Cadherins KW - 0 KW - DNA Primers KW - DNA, Neoplasm KW - Homeodomain Proteins KW - MicroRNAs KW - RNA, Neoplasm KW - Transcription Factors KW - ZEB1 protein, human KW - Zinc Finger E-box-Binding Homeobox 1 KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Index Medicus KW - Humans KW - Cell Line, Tumor KW - DNA Methylation -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Transcription Factors -- genetics KW - Gene Expression Regulation, Neoplastic KW - Phenotype KW - Promoter Regions, Genetic KW - Blotting, Western KW - Tumor Cells, Cultured KW - Down-Regulation KW - Homeodomain Proteins -- genetics KW - Transfection KW - DNA, Neoplasm -- genetics KW - Histone Deacetylases -- genetics KW - Female KW - Cadherins -- deficiency KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- physiopathology KW - MicroRNAs -- genetics KW - Transcription, Genetic KW - RNA, Neoplasm -- genetics KW - Neoplasm Invasiveness -- genetics KW - Breast Neoplasms -- enzymology KW - Cadherins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733836817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=E-cadherin+transcriptional+down-regulation+by+epigenetic+and+microRNA-200+family+alterations+is+related+to+mesenchymal+and+drug-resistant+phenotypes+in+human+breast+cancer+cells.&rft.au=Tryndyak%2C+Volodymyr+P%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2010-06-01&rft.volume=126&rft.issue=11&rft.spage=2575&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.24972 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-23 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/ijc.24972 ER - TY - JOUR T1 - Radiation combined injury: overview of NIAID research. AN - 733548172; 20445395 AB - The term "radiation combined injury" (RCI) is used to describe conditions where radiation injury is coupled with other insults such as burns, wounds, infection, or blunt trauma. A retrospective account of injuries sustained following the atomic bombing of Hiroshima estimates that RCI comprised approximately 65% of all injuries observed. Much of the research that has been performed on RCI was carried out during the Cold War and our understanding of the clinical problem RCI presents does not reflect the latest advances in medicine or science. Because concerns have increased that terrorists might employ radiological or nuclear weapons, and because of the likelihood that victims of such terrorism would experience RCI, the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health sponsored a meeting in 2007 to explore the state of the research in this area, identify programmatic gaps, and establish priorities for future research. As a follow-up to that meeting, in 2008 NIAID sponsored an initiative on RCI, leading to the award of several exploratory/developmental grants, the goals of which are to better understand biological synergy involved in RCI-induced damage, develop improved animal models for various type of RCI, and advance identification and testing of potential countermeasures to treat injuries that would be expected following a radiological or nuclear event. This program has already yielded new insight into the nature of combined injuries and has identified a number of novel and existing compounds that may be effective treatments for this condition. JF - Health physics AU - DiCarlo, Andrea L AU - Ramakrishnan, Narayani AU - Hatchett, Richard J AD - Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Drive, Bethesda, MD 20892, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 863 EP - 867 VL - 98 IS - 6 KW - Index Medicus KW - United States KW - Animals KW - Biomedical Research -- trends KW - Radioactive Hazard Release KW - Wound Healing KW - Humans KW - Disease Models, Animal KW - Mice KW - National Institute of Allergy and Infectious Diseases (U.S.) KW - Comorbidity KW - Rats KW - Nuclear Warfare KW - Dogs KW - Radiation KW - Radiation Injuries -- therapy KW - Radiation Injuries -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733548172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Radiation+combined+injury%3A+overview+of+NIAID+research.&rft.au=DiCarlo%2C+Andrea+L%3BRamakrishnan%2C+Narayani%3BHatchett%2C+Richard+J&rft.aulast=DiCarlo&rft.aufirst=Andrea&rft.date=2010-06-01&rft.volume=98&rft.issue=6&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=1538-5159&rft_id=info:doi/10.1097%2FHP.0b013e3181a6ee32 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-20 N1 - Date created - 2010-05-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1097/HP.0b013e3181a6ee32 ER - TY - JOUR T1 - The genotoxicity of acrylamide and glycidamide in big blue rats. AN - 733535735; 20200216 AB - Acrylamide (AA), a mutagen and rodent carcinogen, recently has been detected in fried and baked starchy foods, a finding that has prompted renewed interest in its potential for toxicity in humans. In the present study, we exposed Big Blue rats to the equivalent of approximately 5 and 10 mg/kg body weight/day of AA or its epoxide metabolite glycidamide (GA) via the drinking water, an AA treatment regimen comparable to those used to produce cancer in rats. After 2 months of dosing, the rats were euthanized and blood was taken for the micronucleus assay; spleens for the lymphocyte Hprt mutant assay; and liver, thyroid, bone marrow, testis (from males), and mammary gland (females) for the cII mutant assay. Neither AA nor GA increased the frequency of micronucleated reticulocytes. In contrast, both compounds produced small (approximately twofold to threefold above background) but significant increases in lymphocyte Hprt mutant frequency (MF, p < 0.05), with the increases having dose-related linear trends (p < 0.05 to p < 0.001). Neither compound increased the cII MF in testis, mammary gland (tumor target tissues), or liver (nontarget tissue), while both compounds induced weak positive increases in bone marrow (nontarget tissue) and thyroid (target tissue). Although the genotoxicity in tumor target tissue was weak, in combination with the responses in surrogate tissues, the results are consistent with AA being a gene mutagen in the rat via metabolism to GA. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Mei, Nan AU - McDaniel, Lea P AU - Dobrovolsky, Vasily N AU - Guo, Xiaoqing AU - Shaddock, Joseph G AU - Mittelstaedt, Roberta A AU - Azuma, Mizuo AU - Shelton, Sharon D AU - McGarrity, Lynda J AU - Doerge, Daniel R AU - Heflich, Robert H AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. nan.mei@fda.hhs.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 412 EP - 421 VL - 115 IS - 2 KW - Epoxy Compounds KW - 0 KW - Mutagens KW - Acrylamide KW - 20R035KLCI KW - glycidamide KW - 6G5ELX5XYN KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Index Medicus KW - Animals KW - Rats, Transgenic KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - DNA Mutational Analysis KW - Micronuclei, Chromosome-Defective -- chemically induced KW - Lymphocytes -- metabolism KW - Rats KW - Mutagenicity Tests KW - Micronucleus Tests KW - Spleen -- drug effects KW - Lymphocytes -- drug effects KW - Female KW - Male KW - Mutation -- drug effects KW - Mutagens -- classification KW - Epoxy Compounds -- classification KW - Mutagens -- toxicity KW - Epoxy Compounds -- toxicity KW - Acrylamide -- classification KW - Acrylamide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733535735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+genotoxicity+of+acrylamide+and+glycidamide+in+big+blue+rats.&rft.au=Mei%2C+Nan%3BMcDaniel%2C+Lea+P%3BDobrovolsky%2C+Vasily+N%3BGuo%2C+Xiaoqing%3BShaddock%2C+Joseph+G%3BMittelstaedt%2C+Roberta+A%3BAzuma%2C+Mizuo%3BShelton%2C+Sharon+D%3BMcGarrity%2C+Lynda+J%3BDoerge%2C+Daniel+R%3BHeflich%2C+Robert+H&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2010-06-01&rft.volume=115&rft.issue=2&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfq069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfq069 ER - TY - JOUR T1 - Bromide and N-acetyl-S-(n-propyl)-L-cysteine in urine from workers exposed to 1-bromopropane solvents from vapor degreasing or adhesive manufacturing. AN - 733517917; 20229238 AB - 1-Bromopropane (1-BP) is an alternative for ozone depleting and other solvents; it is used in aerosol products, adhesives, and cleaning solvents. There is concern that 1-BP may be a reproductive and neurological toxicant. Mercapturic acid conjugates are excreted in urine from 1-BP metabolism involving debromination. The main objectives were to evaluate urinary bromide [Br(-)] and N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys) for assessing 1-BP exposure in workers with low exposure. Workers' 1-BP exposures were measured in their breathing zones with gas chromatography-flame ionization detection via NIOSH 1025. Urine specimens were obtained over a 48-h period at five facilities using vapor degreasers and one adhesive manufacturer. All of the workers' urine was collected into composite samples and analyzed separately representing daily time intervals: at work, after work but before bedtime, and upon awakening. Urinary metabolites were analyzed using intra-coupled plasma-mass spectroscopy for Br(-), and high-performance liquid chromatography and electro-spray ionization mass spectroscopy for AcPrCys. Time-weighted average (TWA) geometric mean (GM) breathing zone concentrations of 1-BP at vapor degreasing facilities were 2.6 and 0.31 ppm, respectively, for workers near degreasers and those remote from degreasers. Urine metabolites showed the same trend as TWA exposures: higher levels were observed for workers near degreasers (48-h GM Br(-) = 8.9 vs. 3.7; 48-h GM AcPrCys = 1.3 vs. 0.12, respectively). Associations of Br(-) and AcPrCys concentrations with 1-BP TWA were statistically significant near degreasers (p < 0.01). This study shows that urinary Br(-) and AcPrCys are useful biomarkers of workers' 1-BP exposures using analyses sensitive enough to measure low exposure jobs. JF - International archives of occupational and environmental health AU - Hanley, Kevin William AU - Petersen, Martin R AU - Cheever, Kenneth L AU - Luo, Lian AD - National Institute for Occupational Safety and Health, Cincinnati, OH, USA. KHanley@cdc.gov Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 571 EP - 584 VL - 83 IS - 5 KW - Air Pollutants, Occupational KW - 0 KW - Bromides KW - Hydrocarbons, Brominated KW - N-acetyl-S-propylcysteine KW - Solvents KW - Acetylcysteine KW - WYQ7N0BPYC KW - 1-bromopropane KW - Y9746DNE68 KW - Index Medicus KW - Socioeconomic Factors KW - Environmental Monitoring KW - Air Pollutants, Occupational -- analysis KW - Humans KW - Adult KW - Middle Aged KW - Hydrocarbons, Brominated -- analysis KW - Time Factors KW - Male KW - Female KW - Bromides -- urine KW - Acetylcysteine -- urine KW - Acetylcysteine -- analogs & derivatives KW - Solvents -- analysis KW - Manufactured Materials KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733517917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+archives+of+occupational+and+environmental+health&rft.atitle=Bromide+and+N-acetyl-S-%28n-propyl%29-L-cysteine+in+urine+from+workers+exposed+to+1-bromopropane+solvents+from+vapor+degreasing+or+adhesive+manufacturing.&rft.au=Hanley%2C+Kevin+William%3BPetersen%2C+Martin+R%3BCheever%2C+Kenneth+L%3BLuo%2C+Lian&rft.aulast=Hanley&rft.aufirst=Kevin&rft.date=2010-06-01&rft.volume=83&rft.issue=5&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=International+archives+of+occupational+and+environmental+health&rft.issn=1432-1246&rft_id=info:doi/10.1007%2Fs00420-010-0524-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-13 N1 - Date created - 2010-05-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s00420-010-0524-4 ER - TY - JOUR T1 - Microprocessor of microRNAs: regulation and potential for therapeutic intervention. AN - 733303186; 20515486 AB - MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs. JF - Molecular cancer AU - Beezhold, Kevin J AU - Castranova, Vince AU - Chen, Fei AD - Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. Y1 - 2010/06/01/ PY - 2010 DA - 2010 Jun 01 SP - 134 VL - 9 KW - MicroRNAs KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Gene Expression Regulation KW - MicroRNAs -- physiology KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733303186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer&rft.atitle=Microprocessor+of+microRNAs%3A+regulation+and+potential+for+therapeutic+intervention.&rft.au=Beezhold%2C+Kevin+J%3BCastranova%2C+Vince%3BChen%2C+Fei&rft.aulast=Beezhold&rft.aufirst=Kevin&rft.date=2010-06-01&rft.volume=9&rft.issue=&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer&rft.issn=1476-4598&rft_id=info:doi/10.1186%2F1476-4598-9-134 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-30 N1 - Date created - 2010-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Cell Res. 2009 Oct 15;315(17):2941-52 [19591824] Blood. 2009 Oct 8;114(15):3265-75 [19641183] Mol Cell. 2009 Oct 23;36(2):340-7 [19854141] Nucleic Acids Res. 2006;34(15):4206-15 [16935882] Cell. 2000 Mar 31;101(1):25-33 [10778853] Nature. 2001 Jan 18;409(6818):363-6 [11201747] Science. 2001 Aug 3;293(5531):834-8 [11452083] Science. 2001 Sep 21;293(5538):2269-71 [11486053] Genes Dev. 2001 Oct 15;15(20):2654-9 [11641272] EMBO J. 2002 Sep 2;21(17):4663-70 [12198168] EMBO J. 2002 Nov 1;21(21):5875-85 [12411505] Nature. 2003 Sep 25;425(6956):415-9 [14508493] Cell. 2003 Oct 17;115(2):209-16 [14567918] Nucleic Acids Res. 2003 Nov 15;31(22):6444-9 [14602902] Genes Dev. 2003 Dec 15;17(24):3011-6 [14681208] Science. 2004 Jan 2;303(5654):95-8 [14631048] Science. 2004 Jan 2;303(5654):83-6 [14657504] RNA. 2004 Feb;10(2):185-91 [14730017] FEBS Lett. 2004 Feb 13;559(1-3):152-8 [14960324] PLoS Biol. 2003 Dec;1(3):E60 [14691535] Nucleic Acids Res. 2004;32(16):4776-85 [15356295] Biochem Biophys Res Commun. 2004 Nov 5;324(1):70-6 [15464984] Cell. 1997 Mar 7;88(5):637-46 [9054503] Nature. 2004 Nov 11;432(7014):235-40 [15531877] Genes Dev. 2004 Dec 15;18(24):3016-27 [15574589] Chem Biol. 2004 Dec;11(12):1619-23 [15610845] EMBO J. 2005 Jan 12;24(1):138-48 [15565168] EMBO J. 2005 Feb 9;24(3):543-53 [15660129] Nat Cell Biol. 2005 Jul;7(7):719-23 [15937477] Science. 2005 Sep 2;309(5740):1573-6 [16081698] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9 [16166262] RNA. 2005 Nov;11(11):1640-7 [16177138] Cell. 2005 Nov 18;123(4):631-40 [16271387] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4034-9 [16495412] Cell. 2006 Jun 2;125(5):827-9 [16751089] Cell. 2006 Jun 2;125(5):887-901 [16751099] Sci STKE. 2007 Jan 2;2007(367):re1 [17200520] Nat Cell Biol. 2007 May;9(5):604-11 [17435748] Mol Cell. 2007 Jun 8;26(5):731-43 [17540598] Cell. 2007 Jun 15;129(6):1141-51 [17524464] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7 [17875987] Nat Struct Mol Biol. 2007 Oct;14(10):934-40 [17873886] Exp Cell Res. 2007 Dec 10;313(20):4196-207 [17765891] Cancer Res. 2008 Jan 15;68(2):425-33 [18199536] Mol Cell. 2008 Jan 18;29(1):1-7 [18206964] Oncology. 2007;72(5-6):397-402 [18196926] Mol Cell Biol. 2008 Mar;28(5):1503-14 [18086880] Blood. 2008 Mar 15;111(6):3183-9 [18187662] Oncogene. 2008 Apr 3;27(15):2128-36 [17968323] J Biol Chem. 2008 Apr 11;283(15):9836-43 [18281287] Nature. 2008 Jul 3;454(7200):56-61 [18548003] Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9970-5 [18632569] Oncogene. 2008 Aug 7;27(34):4712-23 [18408758] Mol Cell Biol. 2008 Nov;28(22):6773-84 [18794355] Biochem Biophys Res Commun. 2008 Dec 5;377(1):114-9 [18834855] Nat Med. 2008 Nov;14(11):1271-7 [18931683] Biochem Soc Trans. 2008 Dec;36(Pt 6):1224-31 [19021530] Nat Struct Mol Biol. 2008 Sep;15(9):902-9 [19172742] J Cell Mol Med. 2009 Jan;13(1):39-53 [19175699] Oncogene. 2009 Mar 12;28(10):1385-92 [19137007] Int J Oncol. 2009 Apr;34(4):1069-75 [19287964] Int J Oncol. 2009 May;34(5):1461-6 [19360360] Blood. 2009 Apr 16;113(16):3801-8 [18941118] Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7016-21 [19359480] Biochem Soc Trans. 2009 Aug;37(Pt 4):918-25 [19614619] Nature. 2009 Jul 23;460(7254):529-33 [19626115] Cell. 2009 Jul 23;138(2):328-39 [19632182] Cell. 2009 Jul 23;138(2):340-51 [19632183] Br J Cancer. 2009 Aug 18;101(4):699-706 [19638978] Mol Cell. 2009 Sep 11;35(5):610-25 [19748357] Cancer Res. 2009 Oct 1;69(19):7569-76 [19773441] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1186/1476-4598-9-134 ER - TY - JOUR T1 - Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein. AN - 733285493; 20515940 AB - Rac1 GTPase regulates a variety of signaling pathways that are implicated in malignant phenotypes. Here, we show that selective inhibition of Rac1 activity by the pharmacologic inhibitor NSC23766 suppressed cell growth in a panel of human breast cancer cell lines, whereas it had little toxicity to normal mammary epithelial cells. NSC23766 elicits its cytotoxicity via two distinct mechanisms in a cell line-dependent manner: induction of G(1) cell cycle arrest in cell lines (MDA-MB-231, MCF7, and T47D) that express retinoblastoma (Rb) protein or apoptosis in Rb-deficient MDA-MB-468 cells. In MDA-MB-231 cells, Rac1 inhibition induced G(1) cell cycle arrest through downregulation of cyclin D1 and subsequent dephosphorylation/inactivation of Rb. By contrast, MDA-MB-468 cells underwent substantial apoptosis that was associated with loss of antiapoptotic proteins survivin and X-linked inhibitor of apoptosis protein (XIAP). Rac1 knockdown by RNAi interference confirmed the specificity of NSC23766 and requirement for Rac1 in the regulation of cyclin D1, survivin, and XIAP in breast cancer cells. Further, NF-kappaB, but not c-Jun NH(2)-terminal kinase or p38 pathways, mediates the survival signal from Rac1. Overall, our results indicate that Rac1 plays a central role in breast cancer cell survival through regulation of NF-kappaB-dependent gene products. JF - Molecular cancer therapeutics AU - Yoshida, Tatsushi AU - Zhang, Yaqin AU - Rivera Rosado, Leslie A AU - Chen, Junjie AU - Khan, Tahira AU - Moon, Sun Young AU - Zhang, Baolin AD - Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug, Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 1657 EP - 1668 VL - 9 IS - 6 KW - Aminoquinolines KW - 0 KW - BIRC5 protein, human KW - CCND1 protein, human KW - Inhibitor of Apoptosis Proteins KW - Microtubule-Associated Proteins KW - NF-kappa B KW - NSC 23766 KW - Neoplasm Proteins KW - Pyrimidines KW - RAC1 protein, human KW - X-Linked Inhibitor of Apoptosis Protein KW - XIAP protein, human KW - Cyclin D1 KW - 136601-57-5 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - JNK Mitogen-Activated Protein Kinases KW - p38 Mitogen-Activated Protein Kinases KW - rac1 GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - MAP Kinase Signaling System -- drug effects KW - Humans KW - Pyrimidines -- pharmacology KW - Cell Line, Tumor KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- enzymology KW - Cell Survival -- drug effects KW - Epithelial Cells -- pathology KW - Mammary Glands, Human -- pathology KW - Down-Regulation -- drug effects KW - Neoplasm Proteins -- metabolism KW - Female KW - NF-kappa B -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Aminoquinolines -- pharmacology KW - Microtubule-Associated Proteins -- metabolism KW - Cyclin D1 -- metabolism KW - Breast Neoplasms -- pathology KW - Apoptosis -- drug effects KW - rac1 GTP-Binding Protein -- antagonists & inhibitors KW - rac1 GTP-Binding Protein -- metabolism KW - G1 Phase -- drug effects KW - Breast Neoplasms -- enzymology KW - X-Linked Inhibitor of Apoptosis Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733285493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Blockade+of+Rac1+activity+induces+G1+cell+cycle+arrest+or+apoptosis+in+breast+cancer+cells+through+downregulation+of+cyclin+D1%2C+survivin%2C+and+X-linked+inhibitor+of+apoptosis+protein.&rft.au=Yoshida%2C+Tatsushi%3BZhang%2C+Yaqin%3BRivera+Rosado%2C+Leslie+A%3BChen%2C+Junjie%3BKhan%2C+Tahira%3BMoon%2C+Sun+Young%3BZhang%2C+Baolin&rft.aulast=Yoshida&rft.aufirst=Tatsushi&rft.date=2010-06-01&rft.volume=9&rft.issue=6&rft.spage=1657&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=1538-8514&rft_id=info:doi/10.1158%2F1535-7163.MCT-09-0906 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-09-16 N1 - Date created - 2010-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/1535-7163.MCT-09-0906 ER - TY - JOUR T1 - Irritancy and allergic responses induced by topical application of ortho-phthalaldehyde. AN - 733105228; 20176622 AB - Although ortho-phthalaldehyde (OPA) has been suggested as an alternative to glutaraldehyde for the sterilization and disinfection of hospital equipment, the toxicity has not been thoroughly investigated. The purpose of these studies was to evaluate the irritancy and sensitization potential of OPA. The EpiDerm Skin Irritation Test was used to evaluate in vitro irritancy potential of OPA and glutaraldehyde. Treatment with 0.4125 and 0.55% OPA induced irritation, while glutaraldehyde exposure at these concentrations did not. Consistent with the in vitro results, OPA induced irritancy, evaluated by ear swelling, when mice were treated with 0.75%. Initial evaluation of the sensitization potential was conducted using the local lymph node assay at concentrations ranging from 0.005 to 0.75%. A concentration-dependent increase in lymphocyte proliferation was observed with a calculated EC3 value of 0.051% compared to that of 0.089%, previously determined for glutaraldehyde. Immunoglobulin (Ig) E-inducing potential was evaluated by phenotypic analysis of draining lymph node (DLN) cells and measurement of total and specific serum IgE levels. The 0.1 and 0.75% exposed groups yielded significant increases in the IgE+B220+ cell population in the lymph nodes while the 0.75% treated group demonstrated significant increases in total IgE, OPA-specific IgE, and OPA-specific IgG(1). In addition, significant increases in interleukin-4 messenger RNA and protein expression in the DLNs were observed in OPA-treated groups. The results demonstrate the dermal irritancy and allergic potential of OPA and raise concern about the proposed/intended use of OPA as a safe alternative to glutaraldehyde. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Anderson, Stacey E AU - Umbright, Christina AU - Sellamuthu, Rajendran AU - Fluharty, Kara AU - Kashon, Michael AU - Franko, Jennifer AU - Jackson, Laurel G AU - Johnson, Victor J AU - Joseph, Pius AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA. Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 435 EP - 443 VL - 115 IS - 2 KW - Allergens KW - 0 KW - Disinfectants KW - Irritants KW - Immunoglobulin E KW - 37341-29-0 KW - o-Phthalaldehyde KW - 643-79-8 KW - Index Medicus KW - Animals KW - Immunoglobulin E -- blood KW - Humans KW - Epidermis -- metabolism KW - Ear, External -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Immunoglobulin E -- biosynthesis KW - Drug Therapy, Combination KW - Epidermis -- drug effects KW - Ear, External -- pathology KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Epidermis -- pathology KW - Local Lymph Node Assay KW - Lymph Nodes -- drug effects KW - Administration, Topical KW - Female KW - Lymph Nodes -- immunology KW - Dermatitis, Allergic Contact -- immunology KW - Dermatitis, Allergic Contact -- etiology KW - Irritants -- toxicity KW - Allergens -- toxicity KW - o-Phthalaldehyde -- classification KW - Dermatitis, Allergic Contact -- pathology KW - Allergens -- classification KW - Disinfectants -- toxicity KW - o-Phthalaldehyde -- toxicity KW - Irritants -- classification KW - Disinfectants -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733105228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Irritancy+and+allergic+responses+induced+by+topical+application+of+ortho-phthalaldehyde.&rft.au=Anderson%2C+Stacey+E%3BUmbright%2C+Christina%3BSellamuthu%2C+Rajendran%3BFluharty%2C+Kara%3BKashon%2C+Michael%3BFranko%2C+Jennifer%3BJackson%2C+Laurel+G%3BJohnson%2C+Victor+J%3BJoseph%2C+Pius&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2010-06-01&rft.volume=115&rft.issue=2&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfq054 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-10 N1 - Date created - 2010-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 May 5;146(2-3):221-7 [10814854] Toxicology. 2009 Jul 10;261(3):152-61 [19467290] Chest. 2000 Oct;118(4):1183-93 [11035694] J Allergy Clin Immunol. 2002 May;109(5):873-8 [11994714] Int Arch Allergy Immunol. 2002 Jul;128(3):204-11 [12119502] Am J Ind Med. 2003 Feb;43(2):196-203 [12541275] Immunol Allergy Clin North Am. 2003 May;23(2):235-50, vii [12803361] Toxicol Sci. 2003 Sep;75(1):89-98 [12832659] J Allergy Clin Immunol. 2004 Feb;113(2):320-6 [14767449] Toxicol Appl Pharmacol. 2004 May 15;197(1):1-8 [15126069] J Allergy Clin Immunol. 2004 Aug;114(2):392-7 [15316522] J Immunol. 1988 Apr 1;140(7):2121-7 [3127461] Immunol Rev. 1988 Feb;102:51-75 [3284816] Thorax. 1995 Feb;50(2):156-9 [7701454] Toxicol Sci. 1999 Apr;48(2):206-17 [10353312] J Appl Toxicol. 1999 Jul-Aug;19(4):261-6 [10439340] Am J Ind Med. 1999 Sep;Suppl 1:139-41 [10519814] Fed Regist. 1999 Mar 23;64(55):14006-7 [10558409] Clin Microbiol Infect. 2004 Nov;10(11):984-9 [15522001] J Hosp Infect. 2005 Jan;59(1):4-11 [15571847] Occup Environ Med. 2005 Apr;62(4):243-50 [15778257] Occup Med (Lond). 2005 Oct;55(7):575-8 [16251378] J Allergy Clin Immunol. 2006 Jun;117(6):1500-1 [16751019] J Occup Health. 2006 Nov;48(6):413-6 [17179633] Lancet. 2007 Jul 28;370(9584):336-41 [17662882] Allergol Int. 2007 Sep;56(3):313-6 [17582212] J Environ Monit. 2008 Nov;10(11):1337-49 [18974903] Toxicol Lett. 2009 Feb 25;185(1):45-50 [19110043] J Immunoassay. 2000 May-Aug;21(2-3):165-209 [10929886] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/toxsci/kfq054 ER - TY - RPRT T1 - Table of contents AN - 705241080 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/705241080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=554&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1,2-DIBROMO-2,4-DICYANOBUTANE (CAS NO. 35691-65-7) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES) AN - 705037673; 20725155 AB - 1,2-Dibromo-2,4-dicyanobutane is used in cosmetics and other household products. We studied the effects of 1,2-dibromo-2,4-dicyanobutane on male and female rats and mice to identify potential toxic or carcinogenic hazards to humans. We applied solutions containing 1,2-dibromo-2,4-dicyanobutane in ethanol to the backs of the animals five times per week for 2 years. Groups of 50 male and female rats received 2, 6, or 18 milligrams (mg) of 1,2-dibromo-2,4-dicyanobutane per kilogram (kg) of body weight, and similar groups of male and female mice received 0.6, 2, or 6 mg 1,2-dibromo-2,4-dicyanobutane per kg. Groups of 50 animals receiving just the ethanol solution served as controls. Tissues from more than 40 sites were examined for every animal. Survival by animals exposed to 1,2-dibromo-2,4-dicyanobutane was the same as for the controls, but rats exposed to the highest concentrations weighed less than the controls. Male and female rats and mice exposed to 1,2-dibromo-2,4-dicyanobutane had increased rates of skin hyperplasia and inflammation. We conclude that 1,2-dibromo-2,4-dicyanobutane was not associated with any increase in cancer in male or female rats or mice. Skin lesions occurred in male and female rats and mice exposed to 1,2-dibromo-2,4-dicyanobutane. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 EP - 171 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Nitriles KW - 1,2-dibromo-2,4-dicyanobutane KW - Toxicity KW - Rodents KW - Pathology KW - Toxicology KW - Animals KW - Dose-Response Relationship, Drug KW - Skin -- pathology KW - Mice KW - Neoplasms, Experimental -- pathology KW - Rats KW - Mice, Inbred Strains KW - Mutagenicity Tests KW - Rats, Inbred F344 KW - Skin -- drug effects KW - Carcinogenicity Tests KW - Female KW - Male KW - Organ Size -- drug effects KW - Neoplasms, Experimental -- chemically induced KW - Nitriles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/705037673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+1%2C2-DIBROMO-2%2C4-DICYANOBUTANE+%28CAS+NO.+35691-65-7%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28DERMAL+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=555&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - FOREWORD AN - 705037374 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/705037374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=555&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 5-(HYDROXYMETHYL)-2-FURFURAL (CAS NO. 67-47-0) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) AN - 704824544; 20725154 AB - 5-(Hy droxymethyl)-2- furfural occurs when sugars are heated in the presence of amino acids. Thus, it occurs naturally in many foods, including dried fruits, caramel products, certain fruit juices, and instant coffee. We studied the effects of 5-(hydroxymethyl)-2-furfural on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing 5-(hydroxymethyl)-2-furfural in deionized water directly into the stomach through a tube to groups of 50 male and female rats and mice for 2 years. Exposed animals received either 188, 375, or 750 milligrams (mg) of 5-(hydroxymethyl)-2-furfural per kilogram (kg) of body weight. Control animals received deionized water with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. There were increased incidences of lesions (degeneration and metaplasia) of the olfactory and respiratory epithelium of the nose in male and female rats and male and female mice that received 5-(hydroxymethyl)-2furfural. Many of the male and female mice receiving 750 mg/kg died before the end of the study, and some exhibited seizures or other signs of neurological response. In the other two groups of female mice receiving 5(hydroxymethyl)-2-furfural, there were increased incidences of hepatocellular adenoma of the liver. We conclude that 5-(hydroxymethyl)-2-furfural caused liver cancer in female mice but did not cause cancer in male or female rats or male mice. In addition, 5-(hydroxymethyl)-2-furfural was associated with increased lesions of the olfactory and respiratory epithelium of the nose in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 7 EP - 13, 15-9, 21-31 passim CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - 5-hydroxymethylfurfural KW - Furaldehyde KW - Rodents KW - Toxicity KW - Toxicology KW - Pathology KW - Cancer KW - Rats KW - Furaldehyde -- toxicity KW - Mice, Inbred Strains KW - Animals KW - Rats, Inbred F344 KW - Dose-Response Relationship, Drug KW - Humans KW - Carcinogenicity Tests KW - Mice KW - Neoplasms, Experimental -- pathology KW - Male KW - Female KW - Neoplasms, Experimental -- chemically induced KW - Furaldehyde -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/704824544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+5-%28HYDROXYMETHYL%29-2-FURFURAL+%28CAS+NO.+67-47-0%29+IN+F344%2FN+RATS+AND+B6C3F1+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=554&rft.spage=0_1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Document feature - Tables; Illustrations; Graphs; References N1 - Last updated - 2015-03-22 ER - TY - RPRT T1 - Table of contents AN - 704823724 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2010/06// PY - 2010 DA - Jun 2010 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/704823724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-06-01&rft.volume=&rft.issue=555&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Jun 2010 N1 - Last updated - 2015-03-22 ER - TY - JOUR T1 - A Handheld Electrostatic Precipitator for Sampling Airborne Particles and Nanoparticles AN - 1770321905; 13184575 AB - Researchers at NIOSH are developing methods for characterizing ultrafine aerosols in workplaces. One method includes the detailed analysis of collected particles using electron microscopy (EM). In order to collect samples for EM at remote workplaces including mining and manufacturing facilities, researchers have developed a handheld electrostatic precipitator (ESP) particle sampler capable of collecting airborne particles including nanoscale materials, for subsequent EM analysis. The handheld ESP has been tested in the laboratory and is currently undergoing beta testing in the field. Gross collection efficiencies were measured with a CPC and net efficiencies by EM analysis of collected samples. Using laboratory-generated NaCl aerosols in the 30-400 nm size range at a flow rate of 55 cc/min and ESP operating voltages between 5.6-6.8 kV, both gross and net efficiencies were measured and showed a similar correlation with voltage, with maximum efficiency of approximately 86% at 6.4 kV. EM images from samples were also used to estimate particle size distributions of the original aerosols and the size-dependent deposition was evaluated for upstream versus downstream locations on the sample media. Results suggest that the number concentration and particle size distribution of sampled aerosols may potentially be estimated from a single ESP sample, but that the accuracy and repeatability of such quantification need to be investigated and refined. NIOSH is planning to license the ESP sampler for commercial manufacturing. JF - Aerosol Science & Technology AU - Miller, Arthur AU - Frey, Garrett AU - King, Grant AU - Sunderman, Carl AD - NIOSH Spokane Research Lab, Spokane, Washington, USA Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 417 EP - 427 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 44 IS - 6 SN - 0278-6826, 0278-6826 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN) KW - Particle size distribution KW - Aerosols KW - Voltage KW - Electric potential KW - Images KW - Electrostatic precipitators KW - Workplaces KW - Nanostructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770321905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=A+Handheld+Electrostatic+Precipitator+for+Sampling+Airborne+Particles+and+Nanoparticles&rft.au=Miller%2C+Arthur%3BFrey%2C+Garrett%3BKing%2C+Grant%3BSunderman%2C+Carl&rft.aulast=Miller&rft.aufirst=Arthur&rft.date=2010-06-01&rft.volume=44&rft.issue=6&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786821003692063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 24 N1 - Last updated - 2016-03-04 DO - http://dx.doi.org/10.1080/02786821003692063 ER - TY - GEN T1 - The Mental and Emotional Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health AN - 1018480954; ED530917 AB - Children, like adults, may have mental health problems, including depression and anxiety. They may also have behavioral conditions, such as conduct disorders; cognitive disorders, such as autism spectrum disorder; or neurological conditions, such as Tourette Syndrome. Children may also be affected by delays in their physical, cognitive, or emotional development. The 2007 National Survey of Children's Health asked parents whether their children had ever been diagnosed with, and currently had, any of these seven conditions. This chartbook addresses the health and well-being of the population of children whose parents reported that their children had at least one of these conditions. Note, however, that these data are based entirely on parental reports and have not been independently verified; in addition, they only include children whose parents reported that they have been told that they have one of these conditions by a doctor or other health care provider. This chartbook presents a range of indicators on the health and well-being of children who have been diagnosed with emotional, behavioral, or developmental conditions on the national level. For each state, this report shows the prevalence of the seven conditions (grouped together) and the major demographic characteristics of children who have at least one of the conditions. Together, these data paint a picture of a large and diverse population of children with multiple, complex needs. These children and their families may need services--including mental and physical health care, special education, and social services and support--from a variety of systems and providers. These analyses provide a useful first step in delineating the relationships among these conditions, children's socioeconomic characteristics, and access to health care. However, much more research is needed to fully understand these complex relationships. Appended are: (1) Technical Appendix; and (2) Survey Questions on the Presence of Conditions. (Contains 2 footnotes.) [For related reports, see "Children with Special Health Care Needs in Context: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530916); "The Health and Well-Being of Children: A Portrait of States and the Nation 2007. The National Survey of Children's Health 2007" (ED530918); and "The Health and Well-Being of Children in Rural Areas: A Portrait of the Nation 2007. The National Survey of Children's Health" (ED530919).] Y1 - 2010/06// PY - 2010 DA - June 2010 SP - 56 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Special Education KW - Cognitive Development KW - Anxiety KW - Depression (Psychology) KW - Well Being KW - Pervasive Developmental Disorders KW - Child Health KW - Mental Health KW - National Surveys KW - Children KW - Neurological Impairments KW - Emotional Development KW - Rural Areas KW - Health Needs KW - Behavior Disorders KW - Mental Disorders KW - Social Services KW - Parent Attitudes KW - Access to Health Care KW - Autism KW - Portraiture KW - Physical Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1018480954?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - A Single-Pass Orifice System To Assess Red Blood Cell Fragility T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754245189; 5789786 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Herbertson, Luke Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Erythrocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754245189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=A+Single-Pass+Orifice+System+To+Assess+Red+Blood+Cell+Fragility&rft.au=Herbertson%2C+Luke&rft.aulast=Herbertson&rft.aufirst=Luke&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Human Factors and When to Evaluate the Device T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754243140; 5789687 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Patel-Raman, Sonna AU - LaRose, Jeffrey Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Human factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=Human+Factors+and+When+to+Evaluate+the+Device&rft.au=Patel-Raman%2C+Sonna%3BLaRose%2C+Jeffrey&rft.aulast=Patel-Raman&rft.aufirst=Sonna&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Assessing Shear-Induced Platelet Activation: In Vitro Comparison between Human and Bovine Blood T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754235676; 5789830 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Lu, Qijin Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Blood KW - Platelets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=Assessing+Shear-Induced+Platelet+Activation%3A+In+Vitro+Comparison+between+Human+and+Bovine+Blood&rft.au=Lu%2C+Qijin&rft.aulast=Lu&rft.aufirst=Qijin&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA's Role & Position on the Harmonization By Doing Initiative T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754232059; 5789535 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Chen, Eric Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754232059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=FDA%27s+Role+%26amp%3B+Position+on+the+Harmonization+By+Doing+Initiative&rft.au=Chen%2C+Eric&rft.aulast=Chen&rft.aufirst=Eric&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Interlaboratory Measurements of Flow Parameters for Comparison to CFD Simulations of FDA's Nozzle Model T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754221652; 5789800 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Hariharan, Prasanna Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - Simulation KW - FDA KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=Interlaboratory+Measurements+of+Flow+Parameters+for+Comparison+to+CFD+Simulations+of+FDA%27s+Nozzle+Model&rft.au=Hariharan%2C+Prasanna&rft.aulast=Hariharan&rft.aufirst=Prasanna&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Designing LVAD Trials - FDA Perspective T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754219937; 5789543 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Chen, Eric Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - FDA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=Designing+LVAD+Trials+-+FDA+Perspective&rft.au=Chen%2C+Eric&rft.aulast=Chen&rft.aufirst=Eric&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Turbulence Modeling as a Source of Error in FDA's "Critical Path" Interlaboratory Computational Study of Flow in a Nozzle Model T2 - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AN - 754218658; 5789567 JF - 56th Annual Conference of the American Society for Artificial Internal Organs (ASAIO 2010) AU - Stewart, Sandy Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 KW - FDA KW - Turbulence KW - Models KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754218658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.atitle=Turbulence+Modeling+as+a+Source+of+Error+in+FDA%27s+%22Critical+Path%22+Interlaboratory+Computational+Study+of+Flow+in+a+Nozzle+Model&rft.au=Stewart%2C+Sandy&rft.aulast=Stewart&rft.aufirst=Sandy&rft.date=2010-05-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Conference+of+the+American+Society+for+Artificial+Internal+Organs+%28ASAIO+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.asaio.com/clientuploads/pdf/2010/2010%20ASAIOProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Monkeys quickly learn and generalize visual categories without lateral prefrontal cortex. AN - 733135812; 20510855 AB - Categorization is a basic mental process that helps individuals distinguish among groups of negative and positive objects, e.g., poisons and nutrients, or predators and prey. Monkey experiments have suggested that lateral prefrontal cortex (LPFC) participates in learning and processing visual categories. However, in humans category specific visual agnosia follows inferior temporal cortex but not LPFC damage. Here, we use a new behavioral approach to show that both normal monkeys and those with bilateral removal of LPFC learn and generalize perceptual categories of related visual stimuli rapidly without explicit instruction. These results strongly indicate that visual categorization occurs at some earlier stage of feed-forward processing, presumably in temporal cortex, without top-down information from LPFC. Copyright 2010 Elsevier Inc. All rights reserved. JF - Neuron AU - Minamimoto, Takafumi AU - Saunders, Richard C AU - Richmond, Barry J AD - Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. minamoto@nirs.go.jp Y1 - 2010/05/27/ PY - 2010 DA - 2010 May 27 SP - 501 EP - 507 VL - 66 IS - 4 KW - Index Medicus KW - Animals KW - Macaca mulatta KW - Photic Stimulation -- methods KW - Pattern Recognition, Visual -- classification KW - Learning -- physiology KW - Prefrontal Cortex -- physiology KW - Pattern Recognition, Visual -- physiology KW - Reaction Time -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733135812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Monkeys+quickly+learn+and+generalize+visual+categories+without+lateral+prefrontal+cortex.&rft.au=Minamimoto%2C+Takafumi%3BSaunders%2C+Richard+C%3BRichmond%2C+Barry+J&rft.aulast=Minamimoto&rft.aufirst=Takafumi&rft.date=2010-05-27&rft.volume=66&rft.issue=4&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=1097-4199&rft_id=info:doi/10.1016%2Fj.neuron.2010.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-17 N1 - Date created - 2010-05-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neuron. 2010 May 27;66(4):471-3 [20510850] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuron.2010.04.010 ER - TY - CPAPER T1 - Travel-related Schistosomiasis, Strongyloidiasis, Filariasis, and Toxocariasis: The Risk of Infection and the Diagnostic Relevance of Blood Eosinophilia T2 - 3rd Northern European Conference on Travel Medicine (NECTM 2010) AN - 754240771; 5793409 JF - 3rd Northern European Conference on Travel Medicine (NECTM 2010) AU - Baaten, G AU - Sonder, G AU - Van Gool, T AU - Kint, J AU - van den Hoek, A Y1 - 2010/05/26/ PY - 2010 DA - 2010 May 26 KW - Infection KW - Schistosomiasis KW - Strongyloidiasis KW - Blood KW - Eosinophilia KW - Filariasis KW - Toxocariasis KW - Schistosoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Northern+European+Conference+on+Travel+Medicine+%28NECTM+2010%29&rft.atitle=Travel-related+Schistosomiasis%2C+Strongyloidiasis%2C+Filariasis%2C+and+Toxocariasis%3A+The+Risk+of+Infection+and+the+Diagnostic+Relevance+of+Blood+Eosinophilia&rft.au=Baaten%2C+G%3BSonder%2C+G%3BVan+Gool%2C+T%3BKint%2C+J%3Bvan+den+Hoek%2C+A&rft.aulast=Baaten&rft.aufirst=G&rft.date=2010-05-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Northern+European+Conference+on+Travel+Medicine+%28NECTM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nectm.com/OnlineProgramme&Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Prospective Study on the Incidence and Risk Factors of Probable Dengue Virus Infection among Dutch Travellers T2 - 3rd Northern European Conference on Travel Medicine (NECTM 2010) AN - 754235222; 5793340 JF - 3rd Northern European Conference on Travel Medicine (NECTM 2010) AU - Baaten, G AU - Sonder, G AU - Van Gool, T AU - Kint, J AU - van den Hoek, A Y1 - 2010/05/26/ PY - 2010 DA - 2010 May 26 KW - Infection KW - Dengue KW - Travellers KW - Risk factors KW - Dengue virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Northern+European+Conference+on+Travel+Medicine+%28NECTM+2010%29&rft.atitle=A+Prospective+Study+on+the+Incidence+and+Risk+Factors+of+Probable+Dengue+Virus+Infection+among+Dutch+Travellers&rft.au=Baaten%2C+G%3BSonder%2C+G%3BVan+Gool%2C+T%3BKint%2C+J%3Bvan+den+Hoek%2C+A&rft.aulast=Baaten&rft.aufirst=G&rft.date=2010-05-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Northern+European+Conference+on+Travel+Medicine+%28NECTM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nectm.com/OnlineProgramme&Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Proteomic Analysis of Mycobacterium vanbaalenii PYR-1 for the Elucidation of the Biodegradation Network of Polycyclic Aromatic Hydrocarbons T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839682991; 5919971 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Holland, Ricky AU - Kweon, Oh-Gew AU - Kim, Seong-Jae AU - Gao, Yuan AU - Cerniglia, Carl AU - Yu, Li-Rong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Polycyclic aromatic hydrocarbons KW - Biodegradation KW - Proteomics KW - Aromatic hydrocarbons KW - {Q2} KW - Mycobacterium vanbaalenii KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839682991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Proteomic+Analysis+of+Mycobacterium+vanbaalenii+PYR-1+for+the+Elucidation+of+the+Biodegradation+Network+of+Polycyclic+Aromatic+Hydrocarbons&rft.au=Holland%2C+Ricky%3BKweon%2C+Oh-Gew%3BKim%2C+Seong-Jae%3BGao%2C+Yuan%3BCerniglia%2C+Carl%3BYu%2C+Li-Rong&rft.aulast=Holland&rft.aufirst=Ricky&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Using a Portable Hand-held Ion Mobility Spectrometer to Screen Dietary Supplements for Fluoxetine and Sibutramine T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839676471; 5920291 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Dunn, Jamie AU - Gryniewicz-Ruzicka, Connie AU - Mecker, Laura AU - Kauffman, John AU - Westenberger, Benjamin AU - Buhse, Lucinda Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mobility KW - Dietary supplements KW - Fluoxetine KW - Sibutramine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839676471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Using+a+Portable+Hand-held+Ion+Mobility+Spectrometer+to+Screen+Dietary+Supplements+for+Fluoxetine+and+Sibutramine&rft.au=Dunn%2C+Jamie%3BGryniewicz-Ruzicka%2C+Connie%3BMecker%2C+Laura%3BKauffman%2C+John%3BWestenberger%2C+Benjamin%3BBuhse%2C+Lucinda&rft.aulast=Dunn&rft.aufirst=Jamie&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of a Scheduled-MRM Assay for Regulatory Analysis of the Allergenic Milk Protein alpha-S1-casein Utilizing an Intact 15N-labeled Internal Standard T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839675069; 5919553 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Scholl, Peter AU - Shefcheck, Kevin AU - Callahan, John AU - Ross, Mark AU - Newsome, G Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Milk KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839675069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Development+of+a+Scheduled-MRM+Assay+for+Regulatory+Analysis+of+the+Allergenic+Milk+Protein+alpha-S1-casein+Utilizing+an+Intact+15N-labeled+Internal+Standard&rft.au=Scholl%2C+Peter%3BShefcheck%2C+Kevin%3BCallahan%2C+John%3BRoss%2C+Mark%3BNewsome%2C+G&rft.aulast=Scholl&rft.aufirst=Peter&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Screening Foods for Unknown Chemical Contaminants by Non-Targeted LC/MSn Analysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839672802; 5918995 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Croley, Timothy AU - White, Kevin AU - Wong, Jon AU - Callahan, John AU - Musser, Steve AU - Antler, Margaret AU - Lashin, Vitaly AU - Mcgibbon, Graham Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Chemical pollution KW - Contaminants KW - Food KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839672802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Screening+Foods+for+Unknown+Chemical+Contaminants+by+Non-Targeted+LC%2FMSn+Analysis&rft.au=Croley%2C+Timothy%3BWhite%2C+Kevin%3BWong%2C+Jon%3BCallahan%2C+John%3BMusser%2C+Steve%3BAntler%2C+Margaret%3BLashin%2C+Vitaly%3BMcgibbon%2C+Graham&rft.aulast=Croley&rft.aufirst=Timothy&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Application of Top-Down Mass Spectrometry to the Validation of In-Silico Predicted Protein Mutations and Sequence Errors T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839671816; 5919303 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - McFarland, Melinda AU - Callahan, John AU - Andrzejewski, Denis AU - Bell, Rebecca AU - Strain, Errol AU - Musser, Steven Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Mutation KW - Amino acid sequence KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839671816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Application+of+Top-Down+Mass+Spectrometry+to+the+Validation+of+In-Silico+Predicted+Protein+Mutations+and+Sequence+Errors&rft.au=McFarland%2C+Melinda%3BCallahan%2C+John%3BAndrzejewski%2C+Denis%3BBell%2C+Rebecca%3BStrain%2C+Errol%3BMusser%2C+Steven&rft.aulast=McFarland&rft.aufirst=Melinda&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Investigation of Gas-phase Phosphate Transfer of Phosphopeptides in Tandem Mass Spectrometry Using Collision-induced Dissociation and Electron Transfer Dissociation T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667811; 5921227 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Gao, Yuan AU - Yu, Li-Rong Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Phosphate KW - Electron transfer KW - Dissociation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Investigation+of+Gas-phase+Phosphate+Transfer+of+Phosphopeptides+in+Tandem+Mass+Spectrometry+Using+Collision-induced+Dissociation+and+Electron+Transfer+Dissociation&rft.au=Gao%2C+Yuan%3BYu%2C+Li-Rong&rft.aulast=Gao&rft.aufirst=Yuan&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Mass Spectrometric Investigations of Bisphenol A and Other Migrants in Canned Food T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667694; 5920832 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Ackerman, Luke AU - Noonan, Gregory AU - Roach, John AU - Mazzola, Eugene AU - Delmonte, Pierluigi AU - Begley, Timothy Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Migrants KW - Bisphenol A KW - Canned food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Mass+Spectrometric+Investigations+of+Bisphenol+A+and+Other+Migrants+in+Canned+Food&rft.au=Ackerman%2C+Luke%3BNoonan%2C+Gregory%3BRoach%2C+John%3BMazzola%2C+Eugene%3BDelmonte%2C+Pierluigi%3BBegley%2C+Timothy&rft.aulast=Ackerman&rft.aufirst=Luke&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Inter-laboratory Validation of a Modified QuEChERS and LC-MS/MS Method for Analysis of >200 Pesticide Residues in Six Fatty Food Products T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839667203; 5921359 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Lin, Yi AU - Chamkasem, Narong AU - Chang, Kai AU - Wong, Jon Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pesticide residues KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839667203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Inter-laboratory+Validation+of+a+Modified+QuEChERS+and+LC-MS%2FMS+Method+for+Analysis+of+%26gt%3B200+Pesticide+Residues+in+Six+Fatty+Food+Products&rft.au=Lin%2C+Yi%3BChamkasem%2C+Narong%3BChang%2C+Kai%3BWong%2C+Jon&rft.aulast=Lin&rft.aufirst=Yi&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination of indole in seafood by headspace SPME GC-MS. T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839666786; 5920842 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Bencsath, F AU - Abraham, Ann AU - Benner, Jr., Ronald Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Seafood KW - Indoles KW - Solid phase methods KW - Headspace KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839666786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+of+indole+in+seafood+by+headspace+SPME+GC-MS.&rft.au=Bencsath%2C+F%3BAbraham%2C+Ann%3BBenner%2C+Jr.%2C+Ronald&rft.aulast=Bencsath&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Cross-Validation of Supported-Liquid Extraction and Solid-Phase Extraction Methods for Soy Isoflavones in Serum and Urine Using UPLC-ES/MS/MS T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839666618; 5920716 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Woodling, Kellie AU - Twaddle, Nathan AU - Doerge, Daniel Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Urine KW - Isoflavones KW - Soybeans KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839666618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Cross-Validation+of+Supported-Liquid+Extraction+and+Solid-Phase+Extraction+Methods+for+Soy+Isoflavones+in+Serum+and+Urine+Using+UPLC-ES%2FMS%2FMS&rft.au=Woodling%2C+Kellie%3BTwaddle%2C+Nathan%3BDoerge%2C+Daniel&rft.aulast=Woodling&rft.aufirst=Kellie&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination of nitrofuran metabolites in shrimp by liquid chromatography-tandem mass spectrometry in APCI mode using 1 Hr sonication extraction T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839665968; 5920739 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - An, Haejung AU - Henry, Mark AU - Cain, Teresa AU - Files, Darin AU - Paek, Han AU - Farley, Dennis Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Metabolites KW - Nitrofurans KW - Sonication KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839665968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+of+nitrofuran+metabolites+in+shrimp+by+liquid+chromatography-tandem+mass+spectrometry+in+APCI+mode+using+1+Hr+sonication+extraction&rft.au=An%2C+Haejung%3BHenry%2C+Mark%3BCain%2C+Teresa%3BFiles%2C+Darin%3BPaek%2C+Han%3BFarley%2C+Dennis&rft.aulast=An&rft.aufirst=Haejung&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Strategy for Automatic Interpretation of MS Data in Target Compound Analysis: Evaluation Methods for Comparing Data Against Acceptance Criteria T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839665801; 5920351 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Heller, David AU - Li, Hui Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Data processing KW - Automation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839665801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Strategy+for+Automatic+Interpretation+of+MS+Data+in+Target+Compound+Analysis%3A+Evaluation+Methods+for+Comparing+Data+Against+Acceptance+Criteria&rft.au=Heller%2C+David%3BLi%2C+Hui&rft.aulast=Heller&rft.aufirst=David&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Mass Spectrometry Based Glycomic Approach for Identification of Carbohydrate Dependant Virulence Factors Using Caenorhabditis elegans as a Surrogate Host T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839665073; 5920640 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Rahman, Mizanur AU - Hodgkin, Jonathan AU - Cipollo, John Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Carbohydrates KW - Virulence factors KW - {Q2} KW - Caenorhabditis elegans KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839665073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=A+Mass+Spectrometry+Based+Glycomic+Approach+for+Identification+of+Carbohydrate+Dependant+Virulence+Factors+Using+Caenorhabditis+elegans+as+a+Surrogate+Host&rft.au=Rahman%2C+Mizanur%3BHodgkin%2C+Jonathan%3BCipollo%2C+John&rft.aulast=Rahman&rft.aufirst=Mizanur&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination of the binding sites of dimethylphenylisocyanate on human serum albumin T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839664582; 5920369 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Hettick, Justin AU - Ruwona, Tinashe AU - Siegel, Paul Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Human serum albumin KW - Albumin KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+of+the+binding+sites+of+dimethylphenylisocyanate+on+human+serum+albumin&rft.au=Hettick%2C+Justin%3BRuwona%2C+Tinashe%3BSiegel%2C+Paul&rft.aulast=Hettick&rft.aufirst=Justin&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination of Perfluorochemicals in Milk Using Liquid Chromatography - Tandem Mass Spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839664269; 5921398 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Heiserman, Wendy AU - Noonan, Gregory AU - South, Paul AU - Begley, Timothy AU - Diachenko, Gregory Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Mass spectroscopy KW - Milk KW - Liquid chromatography KW - Perfluorochemicals KW - Chromatography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839664269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+of+Perfluorochemicals+in+Milk+Using+Liquid+Chromatography+-+Tandem+Mass+Spectrometry&rft.au=Heiserman%2C+Wendy%3BNoonan%2C+Gregory%3BSouth%2C+Paul%3BBegley%2C+Timothy%3BDiachenko%2C+Gregory&rft.aulast=Heiserman&rft.aufirst=Wendy&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination and Risk Assessment of Arsenic compounds in Agricultural Products by Anion-Exchange Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839663838; 5920783 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Park, Sung-Kug AU - Choi, Hoon AU - Park, Hee-Ra AU - Paek, Ock-Jin AU - Kang, Young-Woon AU - Jo, Cheon-Ho AU - Kim, Dong-Sul Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Spectrometry KW - Risk assessment KW - Arsenic KW - Liquid chromatography KW - Agricultural products KW - Chromatography KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839663838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+and+Risk+Assessment+of+Arsenic+compounds+in+Agricultural+Products+by+Anion-Exchange+Liquid+Chromatography+with+Inductively+Coupled+Plasma-Mass+Spectrometry&rft.au=Park%2C+Sung-Kug%3BChoi%2C+Hoon%3BPark%2C+Hee-Ra%3BPaek%2C+Ock-Jin%3BKang%2C+Young-Woon%3BJo%2C+Cheon-Ho%3BKim%2C+Dong-Sul&rft.aulast=Park&rft.aufirst=Sung-Kug&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Characterization of Brevetoxin Metabolites in Clam by LC-MS/MS T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839662874; 5920125 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Abraham, Ann AU - El Said, Kathleen AU - Wang, Yuesong AU - Jester, Edward AU - Hooe-Rollman, Jennifer AU - Granade, Hudson AU - Plakas, Steven Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Metabolites KW - Brevetoxin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839662874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Characterization+of+Brevetoxin+Metabolites+in+Clam+by+LC-MS%2FMS&rft.au=Abraham%2C+Ann%3BEl+Said%2C+Kathleen%3BWang%2C+Yuesong%3BJester%2C+Edward%3BHooe-Rollman%2C+Jennifer%3BGranade%2C+Hudson%3BPlakas%2C+Steven&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Quantification of bisphenol-A for pharmacokinetic evaluations using stable labeled dosing material and LC-ES/MS/MS. T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839660828; 5919397 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Twaddle, Nathan AU - Vanlandingham, Michelle AU - Williams, Lee AU - Doerge, Daniel Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pharmacokinetics KW - Bisphenol A KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839660828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Quantification+of+bisphenol-A+for+pharmacokinetic+evaluations+using+stable+labeled+dosing+material+and+LC-ES%2FMS%2FMS.&rft.au=Twaddle%2C+Nathan%3BVanlandingham%2C+Michelle%3BWilliams%2C+Lee%3BDoerge%2C+Daniel&rft.aulast=Twaddle&rft.aufirst=Nathan&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - LC/MS/MS Analysis of Vitamin Levels in Plasma from Children in the Arkansas Delta Region T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839659939; 5919383 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Beger, Rick AU - Pence, Lisa AU - Williams, Anna AU - Wise, Carolyn AU - McCabe-Sellers, Beverly Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - USA, Arkansas KW - Vitamins KW - Children KW - Deltas KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839659939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=LC%2FMS%2FMS+Analysis+of+Vitamin+Levels+in+Plasma+from+Children+in+the+Arkansas+Delta+Region&rft.au=Beger%2C+Rick%3BPence%2C+Lisa%3BWilliams%2C+Anna%3BWise%2C+Carolyn%3BMcCabe-Sellers%2C+Beverly&rft.aulast=Beger&rft.aufirst=Rick&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Intact protein profiling of pathogens using LCMS, protein feature extraction software and rigorous differential analysis T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839658967; 5919316 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Andrzejewski, Denis AU - McFarland, Melinda AU - Bell, Rebecca AU - Callahan, John AU - Musser, Steve AU - Kitagawa, Norton AU - Meza, Jose AU - Kilby, Greg AU - Bhat, Vadiraja Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - Computer programs KW - Software KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Intact+protein+profiling+of+pathogens+using+LCMS%2C+protein+feature+extraction+software+and+rigorous+differential+analysis&rft.au=Andrzejewski%2C+Denis%3BMcFarland%2C+Melinda%3BBell%2C+Rebecca%3BCallahan%2C+John%3BMusser%2C+Steve%3BKitagawa%2C+Norton%3BMeza%2C+Jose%3BKilby%2C+Greg%3BBhat%2C+Vadiraja&rft.aulast=Andrzejewski&rft.aufirst=Denis&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Determination of perfluorochemicals in food packaging by LC-MS/MS T2 - 58th ASMS Conference on Mass Spectrometry and Allied Topics AN - 839658189; 5919499 JF - 58th ASMS Conference on Mass Spectrometry and Allied Topics AU - Xu, Yichuan AU - Noonan, Gregory AU - Begley, Timothy AU - diachenko, Gregory Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Packaging KW - Perfluorochemicals KW - Food KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839658189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.atitle=Determination+of+perfluorochemicals+in+food+packaging+by+LC-MS%2FMS&rft.au=Xu%2C+Yichuan%3BNoonan%2C+Gregory%3BBegley%2C+Timothy%3Bdiachenko%2C+Gregory&rft.aulast=Xu&rft.aufirst=Yichuan&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=58th+ASMS+Conference+on+Mass+Spectrometry+and+Allied+Topics&rft.issn=&rft_id=info:doi/ L2 - http://www.asms.org/Conferences/AnnualConference/Program/tabid/113/Def LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Multi-year Comparative Analysis of Salmonella PFGE Subtypes Isolated from Retail Meats and Humans T2 - 110th General Meeting of the American Society for Microbiology AN - 839654503; 5893610 JF - 110th General Meeting of the American Society for Microbiology AU - Green, H AU - Brown, S AU - Abbott, J AU - Friedman, S AU - Ayers, S AU - Gerner- Smidt, P AU - Zhao, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Meat KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839654503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Multi-year+Comparative+Analysis+of+Salmonella+PFGE+Subtypes+Isolated+from+Retail+Meats+and+Humans&rft.au=Green%2C+H%3BBrown%2C+S%3BAbbott%2C+J%3BFriedman%2C+S%3BAyers%2C+S%3BGerner-+Smidt%2C+P%3BZhao%2C+S&rft.aulast=Green&rft.aufirst=H&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Strong Transcriptional Activation by Cooperative Binding of BvgA to Multiple Weak Binding Sites in the Pertussis Toxin Promoter of Bordetella pertussis. T2 - 110th General Meeting of the American Society for Microbiology AN - 839652947; 5894093 JF - 110th General Meeting of the American Society for Microbiology AU - Chen, Q AU - Boucher, P AU - Stibitz, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Toxins KW - Cooperatives KW - Transcription activation KW - Promoters KW - Pertussis toxin KW - Pertussis KW - {Q2} KW - Bordetella pertussis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839652947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Strong+Transcriptional+Activation+by+Cooperative+Binding+of+BvgA+to+Multiple+Weak+Binding+Sites+in+the+Pertussis+Toxin+Promoter+of+Bordetella+pertussis.&rft.au=Chen%2C+Q%3BBoucher%2C+P%3BStibitz%2C+S&rft.aulast=Chen&rft.aufirst=Q&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Identification of Shigella-specific Sequences and Their Application in Real-time PCR Detection of Shigella spp T2 - 110th General Meeting of the American Society for Microbiology AN - 839651691; 5894643 JF - 110th General Meeting of the American Society for Microbiology AU - Chen, K-S AU - Cheng, C-M AU - Lin, W Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Polymerase chain reaction KW - Nucleotide sequence KW - {Q2} KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Identification+of+Shigella-specific+Sequences+and+Their+Application+in+Real-time+PCR+Detection+of+Shigella+spp&rft.au=Chen%2C+K-S%3BCheng%2C+C-M%3BLin%2C+W&rft.aulast=Chen&rft.aufirst=K-S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Detection of Seasonal and Novel H1N1 Influenza Virus in Cough-generated Bioaerosols T2 - 110th General Meeting of the American Society for Microbiology AN - 839651399; 5893547 JF - 110th General Meeting of the American Society for Microbiology AU - Blachere, F AU - Lindsley, W AU - Davis, K AU - Thewlis, R AU - Jackson, L AU - Cao, G AU - Palmer, J AU - Clark, K AU - Fisher, M AU - Khakoo, R AU - Davis, S AU - Beezhold, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Seasonal variations KW - Airborne microorganisms KW - Aerosols KW - Sulfur dioxide KW - Influenza KW - {Q2} KW - Influenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839651399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+of+Seasonal+and+Novel+H1N1+Influenza+Virus+in+Cough-generated+Bioaerosols&rft.au=Blachere%2C+F%3BLindsley%2C+W%3BDavis%2C+K%3BThewlis%2C+R%3BJackson%2C+L%3BCao%2C+G%3BPalmer%2C+J%3BClark%2C+K%3BFisher%2C+M%3BKhakoo%2C+R%3BDavis%2C+S%3BBeezhold%2C+D&rft.aulast=Blachere&rft.aufirst=F&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Validation of PRL-SW 24-hour qPCR Salmonella Method for Environmental Swabs, Q-tip, Spongsicles and Sponges. T2 - 110th General Meeting of the American Society for Microbiology AN - 839650930; 5893493 JF - 110th General Meeting of the American Society for Microbiology AU - Cheng, C-M AU - Chou, K AU - Chen, K-S AU - Williams-Hill, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Porifera KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Validation+of+PRL-SW+24-hour+qPCR+Salmonella+Method+for+Environmental+Swabs%2C+Q-tip%2C+Spongsicles+and+Sponges.&rft.au=Cheng%2C+C-M%3BChou%2C+K%3BChen%2C+K-S%3BWilliams-Hill%2C+D&rft.aulast=Cheng&rft.aufirst=C-M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Functional Analysis of ycfR and ycfQ in E. coli O157:H7 Strains Isolated from Outbreaks Associated with Fresh Produce T2 - 110th General Meeting of the American Society for Microbiology AN - 839650861; 5892993 JF - 110th General Meeting of the American Society for Microbiology AU - Deng, K AU - Wang, S AU - Zhang, W AU - Tortorello, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Outbreaks KW - Functional analysis KW - Strains KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Functional+Analysis+of+ycfR+and+ycfQ+in+E.+coli+O157%3AH7+Strains+Isolated+from+Outbreaks+Associated+with+Fresh+Produce&rft.au=Deng%2C+K%3BWang%2C+S%3BZhang%2C+W%3BTortorello%2C+M&rft.aulast=Deng&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - RNA Aptamers as Pathogen Specific Ligands for Concentration and Enhanced Detection of Trypanosoma cruzi in Blood. T2 - 110th General Meeting of the American Society for Microbiology AN - 839650236; 5893588 JF - 110th General Meeting of the American Society for Microbiology AU - Nagarkatti, R AU - Bisht, V AU - Sum, S AU - Duncan, R AU - Nakhasi, H AU - Debrabant, A Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - Blood KW - Aptamers KW - Ligands KW - {Q2} KW - Trypanosoma cruzi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=RNA+Aptamers+as+Pathogen+Specific+Ligands+for+Concentration+and+Enhanced+Detection+of+Trypanosoma+cruzi+in+Blood.&rft.au=Nagarkatti%2C+R%3BBisht%2C+V%3BSum%2C+S%3BDuncan%2C+R%3BNakhasi%2C+H%3BDebrabant%2C+A&rft.aulast=Nagarkatti&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Moraxella catarrhalis Requires the norB Gene Product for Nitric Oxide Detoxification T2 - 110th General Meeting of the American Society for Microbiology AN - 839650090; 5892918 JF - 110th General Meeting of the American Society for Microbiology AU - Wang, W AU - Kinkel, T AU - Lichaa, F AU - Fang, F AU - Hansen, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Detoxification KW - Nitric oxide KW - NorB protein KW - Gene products KW - {Q2} KW - Moraxella catarrhalis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Moraxella+catarrhalis+Requires+the+norB+Gene+Product+for+Nitric+Oxide+Detoxification&rft.au=Wang%2C+W%3BKinkel%2C+T%3BLichaa%2C+F%3BFang%2C+F%3BHansen%2C+E&rft.aulast=Wang&rft.aufirst=W&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Modification of Norfloxacin by a Microbacterium sp. Strain Isolated from a Wastewater Treatment Plant T2 - 110th General Meeting of the American Society for Microbiology AN - 839650084; 5893530 JF - 110th General Meeting of the American Society for Microbiology AU - Kim, D-W AU - Heinze, T AU - Kim, B-S AU - Sutherland, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Wastewater treatment KW - Norfloxacin KW - Strains KW - {Q2} KW - Microbacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Modification+of+Norfloxacin+by+a+Microbacterium+sp.+Strain+Isolated+from+a+Wastewater+Treatment+Plant&rft.au=Kim%2C+D-W%3BHeinze%2C+T%3BKim%2C+B-S%3BSutherland%2C+J&rft.aulast=Kim&rft.aufirst=D-W&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Sequence Analysis of Housekeeping Genes and Identification of SNPs for Speciation of All Cronobacter species T2 - 110th General Meeting of the American Society for Microbiology AN - 839650007; 5894644 JF - 110th General Meeting of the American Society for Microbiology AU - Kumar, N AU - Chen, Y Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Speciation KW - Single-nucleotide polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839650007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Sequence+Analysis+of+Housekeeping+Genes+and+Identification+of+SNPs+for+Speciation+of+All+Cronobacter+species&rft.au=Kumar%2C+N%3BChen%2C+Y&rft.aulast=Kumar&rft.aufirst=N&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Discrimination of Salmonella enterica serovars by identification of single nucleotide polymorphisms T2 - 110th General Meeting of the American Society for Microbiology AN - 839649795; 5893012 JF - 110th General Meeting of the American Society for Microbiology AU - Kazmierczak, M AU - Hayford, A AU - Mammel, M AU - LeClerc, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Discrimination KW - Single-nucleotide polymorphism KW - Anadromous species KW - Nucleotides KW - {Q2} KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Discrimination+of+Salmonella+enterica+serovars+by+identification+of+single+nucleotide+polymorphisms&rft.au=Kazmierczak%2C+M%3BHayford%2C+A%3BMammel%2C+M%3BLeClerc%2C+J&rft.aulast=Kazmierczak&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Resistance of Cronobacter spp. to Bactericidal Activity of Serum is Mediated by OmpT T2 - 110th General Meeting of the American Society for Microbiology AN - 839649612; 5893231 JF - 110th General Meeting of the American Society for Microbiology AU - Franco, A AU - Kothary, M AU - Gopinath, G AU - Jarvis, K AU - Datta, A AU - McCardell, B AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Bactericidal activity KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Resistance+of+Cronobacter+spp.+to+Bactericidal+Activity+of+Serum+is+Mediated+by+OmpT&rft.au=Franco%2C+A%3BKothary%2C+M%3BGopinath%2C+G%3BJarvis%2C+K%3BDatta%2C+A%3BMcCardell%2C+B%3BTall%2C+B&rft.aulast=Franco&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Detection and Prevalence of Salmonella enterica Associated with Fresh-cut Tomatoes Grown on the Eastern Shore of Virginia T2 - 110th General Meeting of the American Society for Microbiology AN - 839649309; 5894638 JF - 110th General Meeting of the American Society for Microbiology AU - Bell, R AU - Zheng, J AU - Allard, S AU - Burrows, E AU - Enurah, A AU - Wang, C AU - McQuiston, J AU - Allard, M AU - Rideout, S AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - USA, Virginia KW - Shores KW - Anadromous species KW - {Q2} KW - Lycopersicon esculentum KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+and+Prevalence+of+Salmonella+enterica+Associated+with+Fresh-cut+Tomatoes+Grown+on+the+Eastern+Shore+of+Virginia&rft.au=Bell%2C+R%3BZheng%2C+J%3BAllard%2C+S%3BBurrows%2C+E%3BEnurah%2C+A%3BWang%2C+C%3BMcQuiston%2C+J%3BAllard%2C+M%3BRideout%2C+S%3BBrown%2C+E&rft.aulast=Bell&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Role of Caspases in Salmonella-Induced Chicken Macrophage Apoptosis T2 - 110th General Meeting of the American Society for Microbiology AN - 839649013; 5892876 JF - 110th General Meeting of the American Society for Microbiology AU - Babu, U AU - Balan, K AU - Gaines, D AU - Mehta, A AU - Harrison, L AU - Bigley, III, E. AU - Raybourne, R AU - Williams, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Caspase KW - Apoptosis KW - Macrophages KW - Anadromous species KW - {Q2} KW - Salmonidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839649013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Role+of+Caspases+in+Salmonella-Induced+Chicken+Macrophage+Apoptosis&rft.au=Babu%2C+U%3BBalan%2C+K%3BGaines%2C+D%3BMehta%2C+A%3BHarrison%2C+L%3BBigley%2C+III%2C+E.%3BRaybourne%2C+R%3BWilliams%2C+K&rft.aulast=Babu&rft.aufirst=U&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Antimicrobial Resistance of Foodborne Salmonella Isolates over the Last Six Decades T2 - 110th General Meeting of the American Society for Microbiology AN - 839648886; 5893010 JF - 110th General Meeting of the American Society for Microbiology AU - Singh, A AU - Zhao, S AU - Ayers, S AU - Fields, P AU - McDermott, P Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Antimicrobial agents KW - Antimicrobial resistance KW - Food KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839648886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Antimicrobial+Resistance+of+Foodborne+Salmonella+Isolates+over+the+Last+Six+Decades&rft.au=Singh%2C+A%3BZhao%2C+S%3BAyers%2C+S%3BFields%2C+P%3BMcDermott%2C+P&rft.aulast=Singh&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Comparison of Salmonella Heidelberg Isolated from Human Patients with those from Animal and Food Sources T2 - 110th General Meeting of the American Society for Microbiology AN - 839647336; 5893001 JF - 110th General Meeting of the American Society for Microbiology AU - Han, J AU - David, D AU - Kaldhone, P AU - Nayak, R AU - Deck, J AU - Stefanova, R AU - Foley, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Germany, Baden-Wuerttemberg, Heidelberg KW - Food sources KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839647336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparison+of+Salmonella+Heidelberg+Isolated+from+Human+Patients+with+those+from+Animal+and+Food+Sources&rft.au=Han%2C+J%3BDavid%2C+D%3BKaldhone%2C+P%3BNayak%2C+R%3BDeck%2C+J%3BStefanova%2C+R%3BFoley%2C+S&rft.aulast=Han&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Reduction of Salmonella Newport Carriage Populations on Tomatoes by Naturally-occurring Epiphytic bacilli: in vivo Findings T2 - 110th General Meeting of the American Society for Microbiology AN - 839646838; 5895187 JF - 110th General Meeting of the American Society for Microbiology AU - Enurah, A AU - Zheng, J AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Bacilli KW - Anadromous species KW - {Q2} KW - Lycopersicon esculentum KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Reduction+of+Salmonella+Newport+Carriage+Populations+on+Tomatoes+by+Naturally-occurring+Epiphytic+bacilli%3A+in+vivo+Findings&rft.au=Enurah%2C+A%3BZheng%2C+J%3BBrown%2C+E&rft.aulast=Enurah&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Prevalence and Distribution of the IS629 Insertion Element in Escherichia coli O157:H7 and its Impact on the Emergence of Atypical O157:H7 Pathogens T2 - 110th General Meeting of the American Society for Microbiology AN - 839646160; 5892987 JF - 110th General Meeting of the American Society for Microbiology AU - Rump, L AU - Feng, P AU - Fischer, M AU - Monday, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839646160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Prevalence+and+Distribution+of+the+IS629+Insertion+Element+in+Escherichia+coli+O157%3AH7+and+its+Impact+on+the+Emergence+of+Atypical+O157%3AH7+Pathogens&rft.au=Rump%2C+L%3BFeng%2C+P%3BFischer%2C+M%3BMonday%2C+S&rft.aulast=Rump&rft.aufirst=L&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Molecular Analysis of Microbial Community in Pyrene- Contaminated Soil during the Bioremediation. T2 - 110th General Meeting of the American Society for Microbiology AN - 839644972; 5895345 JF - 110th General Meeting of the American Society for Microbiology AU - Kim, B-S AU - Kim, S-J AU - Kweon, O-G AU - Wolf, D AU - Davis, K AU - Mattice, J AU - Thoma, G AU - Cerniglia, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Bioremediation KW - Soil contamination KW - Microbial activity KW - Soil pollution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839644972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Analysis+of+Microbial+Community+in+Pyrene-+Contaminated+Soil+during+the+Bioremediation.&rft.au=Kim%2C+B-S%3BKim%2C+S-J%3BKweon%2C+O-G%3BWolf%2C+D%3BDavis%2C+K%3BMattice%2C+J%3BThoma%2C+G%3BCerniglia%2C+C&rft.aulast=Kim&rft.aufirst=B-S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Rhapidosome-like Complex Expressed by Vibrio tubiashii is Part of a Type 6 Secretion System T2 - 110th General Meeting of the American Society for Microbiology AN - 839644912; 5895004 JF - 110th General Meeting of the American Society for Microbiology AU - Kothary, M AU - Curtis, S AU - Gopinath, G AU - Franco, A AU - Jarvis, K AU - Beaubrun, J AU - Mogk, A AU - Bonemann, G AU - Pietrosiuk, A AU - McCardell, B AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Secretion KW - {Q2} KW - Vibrio tubiashii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839644912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Rhapidosome-like+Complex+Expressed+by+Vibrio+tubiashii+is+Part+of+a+Type+6+Secretion+System&rft.au=Kothary%2C+M%3BCurtis%2C+S%3BGopinath%2C+G%3BFranco%2C+A%3BJarvis%2C+K%3BBeaubrun%2C+J%3BMogk%2C+A%3BBonemann%2C+G%3BPietrosiuk%2C+A%3BMcCardell%2C+B%3BTall%2C+B&rft.aulast=Kothary&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Development of Multiplex Real-Time PCR Assays for the Detection of Multiple Antibiotic Resistance Genes Using Melting Temperature (Tm) Analysis of the PCR Products T2 - 110th General Meeting of the American Society for Microbiology AN - 839644528; 5895293 JF - 110th General Meeting of the American Society for Microbiology AU - Sung, K AU - Khan, S AU - Nawaz, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Temperature effects KW - Antibiotic resistance KW - Polymerase chain reaction KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839644528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Development+of+Multiplex+Real-Time+PCR+Assays+for+the+Detection+of+Multiple+Antibiotic+Resistance+Genes+Using+Melting+Temperature+%28Tm%29+Analysis+of+the+PCR+Products&rft.au=Sung%2C+K%3BKhan%2C+S%3BNawaz%2C+M&rft.aulast=Sung&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Cladistic Approach to the Differentiation and Detection of Diverse Lineages of Escherichia coli. T2 - 110th General Meeting of the American Society for Microbiology AN - 839644487; 5895410 JF - 110th General Meeting of the American Society for Microbiology AU - Trujillo, S AU - Esquivel, R AU - Allard, M AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cladistics KW - Differentiation KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839644487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Cladistic+Approach+to+the+Differentiation+and+Detection+of+Diverse+Lineages+of+Escherichia+coli.&rft.au=Trujillo%2C+S%3BEsquivel%2C+R%3BAllard%2C+M%3BBrown%2C+E&rft.aulast=Trujillo&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Construction and Analysis of nidA Mutant in the Degradation of Pyrene by Mycobacterium vanbaalenii PYR-1. T2 - 110th General Meeting of the American Society for Microbiology AN - 839644012; 5895344 JF - 110th General Meeting of the American Society for Microbiology AU - Kim, S-J AU - Song, J AU - Kweon, O AU - Kim, D AU - Cerniglia, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Degradation KW - Mutants KW - Pyrene KW - {Q2} KW - Mycobacterium vanbaalenii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839644012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Construction+and+Analysis+of+nidA+Mutant+in+the+Degradation+of+Pyrene+by+Mycobacterium+vanbaalenii+PYR-1.&rft.au=Kim%2C+S-J%3BSong%2C+J%3BKweon%2C+O%3BKim%2C+D%3BCerniglia%2C+C&rft.aulast=Kim&rft.aufirst=S-J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Simplified Method for Selective Detection of Viable Escherichia coli O157:H7 by Combining Propidium Monoazide Treatment and Real-Time PCR T2 - 110th General Meeting of the American Society for Microbiology AN - 839643975; 5895282 JF - 110th General Meeting of the American Society for Microbiology AU - Li, B. AU - Chen, J-Q Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Polymerase chain reaction KW - Nucleotide sequence KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Simplified+Method+for+Selective+Detection+of+Viable+Escherichia+coli+O157%3AH7+by+Combining+Propidium+Monoazide+Treatment+and+Real-Time+PCR&rft.au=Li%2C+B.%3BChen%2C+J-Q&rft.aulast=Li&rft.aufirst=B.&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Systems Biology Approach to Reconstruct the Polycyclic Aromatic Hydrocarbon degradation network in Mycobacterium vanbaalenii PYR-1. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643956; 5895332 JF - 110th General Meeting of the American Society for Microbiology AU - Kweon, O AU - Kim, S-J AU - Holland, R AU - Gao, Y AU - Yu, L-R AU - Ahn, H AU - Chen, H AU - Baek, S AU - Kim, D AU - Baek, D-H AU - Cerniglia, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Degradation KW - Polycyclic aromatic hydrocarbons KW - Aromatic hydrocarbons KW - {Q2} KW - Mycobacterium vanbaalenii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Systems+Biology+Approach+to+Reconstruct+the+Polycyclic+Aromatic+Hydrocarbon+degradation+network+in+Mycobacterium+vanbaalenii+PYR-1.&rft.au=Kweon%2C+O%3BKim%2C+S-J%3BHolland%2C+R%3BGao%2C+Y%3BYu%2C+L-R%3BAhn%2C+H%3BChen%2C+H%3BBaek%2C+S%3BKim%2C+D%3BBaek%2C+D-H%3BCerniglia%2C+C&rft.aulast=Kweon&rft.aufirst=O&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Comparative Genomics of Salmonella. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643917; 5894837 JF - 110th General Meeting of the American Society for Microbiology AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Genomics KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparative+Genomics+of+Salmonella.&rft.au=Brown%2C+E&rft.aulast=Brown&rft.aufirst=E&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Survival of Different Bacterial Species in Liquid Egg White. T2 - 110th General Meeting of the American Society for Microbiology AN - 839643640; 5895279 JF - 110th General Meeting of the American Society for Microbiology AU - Khan, S AU - Sung, K AU - Nawaz, M AU - Cerniglia, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Survival KW - Albumen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Survival+of+Different+Bacterial+Species+in+Liquid+Egg+White.&rft.au=Khan%2C+S%3BSung%2C+K%3BNawaz%2C+M%3BCerniglia%2C+C&rft.aulast=Khan&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - How Does FDA Use PFGE Data During Outbreaks and Investigations? T2 - 110th General Meeting of the American Society for Microbiology AN - 839643336; 5894901 JF - 110th General Meeting of the American Society for Microbiology AU - Keys, C Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Outbreaks KW - FDA KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839643336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=How+Does+FDA+Use+PFGE+Data+During+Outbreaks+and+Investigations%3F&rft.au=Keys%2C+C&rft.aulast=Keys&rft.aufirst=C&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Molecular Characterization of Fluoroquinolone-Resistant Salmonella strains from Imported food samples T2 - 110th General Meeting of the American Society for Microbiology AN - 839642843; 5895271 JF - 110th General Meeting of the American Society for Microbiology AU - Khan, A AU - Chorng-Ming, C AU - Nawaz, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Food KW - Anadromous species KW - Strains KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Characterization+of+Fluoroquinolone-Resistant+Salmonella+strains+from+Imported+food+samples&rft.au=Khan%2C+A%3BChorng-Ming%2C+C%3BNawaz%2C+M&rft.aulast=Khan&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Detection and Recovery of E. coli O157:H7 from a Variety of Produce Matrices Using a Soak Sample Preparation Procedure T2 - 110th General Meeting of the American Society for Microbiology AN - 839642535; 5893033 JF - 110th General Meeting of the American Society for Microbiology AU - Yoshitomi, K AU - Wetherington, J AU - Nabe, K AU - W. M. Fedio2, AU - Jinneman, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Detection+and+Recovery+of+E.+coli+O157%3AH7+from+a+Variety+of+Produce+Matrices+Using+a+Soak+Sample+Preparation+Procedure&rft.au=Yoshitomi%2C+K%3BWetherington%2C+J%3BNabe%2C+K%3BW.+M.+Fedio2%2C%3BJinneman%2C+K&rft.aulast=Yoshitomi&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Immunomagnetic Isolation of Yersinia pestis from Baby Food using the Pathatrix System. T2 - 110th General Meeting of the American Society for Microbiology AN - 839642495; 5893031 JF - 110th General Meeting of the American Society for Microbiology AU - Hanes, D AU - Davis, M AU - Doran, T AU - Heckman, C AU - Sciulli, R AU - Calimlim, P AU - Ewing-Peeples, L AU - Kothary, M AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Food KW - {Q2} KW - Yersinia pestis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Immunomagnetic+Isolation+of+Yersinia+pestis+from+Baby+Food+using+the+Pathatrix+System.&rft.au=Hanes%2C+D%3BDavis%2C+M%3BDoran%2C+T%3BHeckman%2C+C%3BSciulli%2C+R%3BCalimlim%2C+P%3BEwing-Peeples%2C+L%3BKothary%2C+M%3BTall%2C+B&rft.aulast=Hanes&rft.aufirst=D&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Towards a More Stable rPA Vaccine: The Effects of Substitution of Deamidation-Susceptible Asparagine Residues on Biological Activity and Stability T2 - 110th General Meeting of the American Society for Microbiology AN - 839642006; 5893206 JF - 110th General Meeting of the American Society for Microbiology AU - McNichol, B AU - Verma, A AU - Burns, D AU - Dominguez, R AU - Arciniega, J AU - Stibitz, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Residues KW - Vaccines KW - Asparagine KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839642006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Towards+a+More+Stable+rPA+Vaccine%3A+The+Effects+of+Substitution+of+Deamidation-Susceptible+Asparagine+Residues+on+Biological+Activity+and+Stability&rft.au=McNichol%2C+B%3BVerma%2C+A%3BBurns%2C+D%3BDominguez%2C+R%3BArciniega%2C+J%3BStibitz%2C+S&rft.aulast=McNichol&rft.aufirst=B&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Investigation of the Role of a Conserved Glycine Residue of Enzyme IIA of the N-Acetyl-D-Galactosamine and D-Galactosamine Phosphoenolpyruvate: Carbohydrate Phosphotransferase System of Escherichia coli O157:H7 T2 - 110th General Meeting of the American Society for Microbiology AN - 839641719; 5896139 JF - 110th General Meeting of the American Society for Microbiology AU - Hu, Z. AU - LeClerc, J AU - Mukherjee, A Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Carbohydrates KW - Residues KW - Enzymes KW - Phosphotransferase KW - Glycine KW - D-Galactosamine KW - N-Acetyl-D-galactosamine KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Investigation+of+the+Role+of+a+Conserved+Glycine+Residue+of+Enzyme+IIA+of+the+N-Acetyl-D-Galactosamine+and+D-Galactosamine+Phosphoenolpyruvate%3A+Carbohydrate+Phosphotransferase+System+of+Escherichia+coli+O157%3AH7&rft.au=Hu%2C+Z.%3BLeClerc%2C+J%3BMukherjee%2C+A&rft.aulast=Hu&rft.aufirst=Z.&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Identifying Genomic Diversity in 2009 Salmonella Typhimurium Outbreak Isolates T2 - 110th General Meeting of the American Society for Microbiology AN - 839641648; 5895869 JF - 110th General Meeting of the American Society for Microbiology AU - Lewis, J AU - Mammel, M AU - Hayford, A AU - Gangiredla, J AU - Patel, I AU - Jackson, S AU - Elkins, C AU - LeClerc, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Outbreaks KW - Genomics KW - Species diversity KW - Anadromous species KW - {Q2} KW - Salmonella typhimurium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Identifying+Genomic+Diversity+in+2009+Salmonella+Typhimurium+Outbreak+Isolates&rft.au=Lewis%2C+J%3BMammel%2C+M%3BHayford%2C+A%3BGangiredla%2C+J%3BPatel%2C+I%3BJackson%2C+S%3BElkins%2C+C%3BLeClerc%2C+J&rft.aulast=Lewis&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Single and Multi-Lab Validation of Duplex Real-time PCR for Shigella Detection in Foods T2 - 110th General Meeting of the American Society for Microbiology AN - 839641319; 5893035 JF - 110th General Meeting of the American Society for Microbiology AU - Lin, W AU - Achen, M AU - Sprague, G AU - Wilson, K AU - Bozicevich, T AU - McGrath, T Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Polymerase chain reaction KW - Food KW - Nucleotide sequence KW - {Q2} KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Single+and+Multi-Lab+Validation+of+Duplex+Real-time+PCR+for+Shigella+Detection+in+Foods&rft.au=Lin%2C+W%3BAchen%2C+M%3BSprague%2C+G%3BWilson%2C+K%3BBozicevich%2C+T%3BMcGrath%2C+T&rft.aulast=Lin&rft.aufirst=W&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Investigation of B. anthracis Resistance to Bacteriophage AP50 T2 - 110th General Meeting of the American Society for Microbiology AN - 839641194; 5896184 JF - 110th General Meeting of the American Society for Microbiology AU - Plaut, R AU - Stibitz, S AU - Beaber, J AU - Calendar, R AU - Bishop-Lilly, K AU - Sozhamannan, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Phages KW - Bacteriophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839641194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Investigation+of+B.+anthracis+Resistance+to+Bacteriophage+AP50&rft.au=Plaut%2C+R%3BStibitz%2C+S%3BBeaber%2C+J%3BCalendar%2C+R%3BBishop-Lilly%2C+K%3BSozhamannan%2C+S&rft.aulast=Plaut&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Characterization of Antimicrobial Resistance in Salmonella enterica serotype Typhimurium from 1949-2006 using a Custom Affymetrix High Density Microarray T2 - 110th General Meeting of the American Society for Microbiology AN - 839640717; 5895884 JF - 110th General Meeting of the American Society for Microbiology AU - Harbottle, H AU - Tadesse, D AU - Sabo, J AU - Patel, I AU - Folster, J AU - McDermott, P AU - Jackson, S Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Customs KW - Antimicrobial agents KW - Serotypes KW - Antimicrobial resistance KW - Anadromous species KW - {Q2} KW - Salmonella enterica KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Characterization+of+Antimicrobial+Resistance+in+Salmonella+enterica+serotype+Typhimurium+from+1949-2006+using+a+Custom+Affymetrix+High+Density+Microarray&rft.au=Harbottle%2C+H%3BTadesse%2C+D%3BSabo%2C+J%3BPatel%2C+I%3BFolster%2C+J%3BMcDermott%2C+P%3BJackson%2C+S&rft.aulast=Harbottle&rft.aufirst=H&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Prevalence and Antimicrobial Susceptibility Profiles of Campylobacter Isolates from Poultry Meats, NARMS 2008 T2 - 110th General Meeting of the American Society for Microbiology AN - 839640484; 5892686 JF - 110th General Meeting of the American Society for Microbiology AU - Young, S AU - Mukherjee, S AU - Friedman, S AU - Tong, E AU - McDermott, P AU - Shaohua, Z Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Meat KW - Poultry KW - Antimicrobial agents KW - {Q2} KW - Campylobacter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Prevalence+and+Antimicrobial+Susceptibility+Profiles+of+Campylobacter+Isolates+from+Poultry+Meats%2C+NARMS+2008&rft.au=Young%2C+S%3BMukherjee%2C+S%3BFriedman%2C+S%3BTong%2C+E%3BMcDermott%2C+P%3BShaohua%2C+Z&rft.aulast=Young&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Isolation and Characterization of Tetracycline-Resistant Klebsiella spp. Isolated from Imported Shrimp T2 - 110th General Meeting of the American Society for Microbiology AN - 839640430; 5895798 JF - 110th General Meeting of the American Society for Microbiology AU - Nawaz, M AU - Tran, Q AU - Khan, S AU - Khan, A AU - Sung, K AU - Yan, S AU - Gilbert, J AU - Steele, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q2} KW - Klebsiella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Isolation+and+Characterization+of+Tetracycline-Resistant+Klebsiella+spp.+Isolated+from+Imported+Shrimp&rft.au=Nawaz%2C+M%3BTran%2C+Q%3BKhan%2C+S%3BKhan%2C+A%3BSung%2C+K%3BYan%2C+S%3BGilbert%2C+J%3BSteele%2C+R&rft.aulast=Nawaz&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Modification of FDA's Food Code Based on Significant Survival of Salmonella in Fresh-Cut Tomatoes. T2 - 110th General Meeting of the American Society for Microbiology AN - 839640382; 5895789 JF - 110th General Meeting of the American Society for Microbiology AU - De Jesus, A AU - Whiting, R AU - Bohm, S AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Survival KW - FDA KW - Food KW - Anadromous species KW - {Q2} KW - Lycopersicon esculentum KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Modification+of+FDA%27s+Food+Code+Based+on+Significant+Survival+of+Salmonella+in+Fresh-Cut+Tomatoes.&rft.au=De+Jesus%2C+A%3BWhiting%2C+R%3BBohm%2C+S%3BBrown%2C+E&rft.aulast=De+Jesus&rft.aufirst=A&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - A Revised and Expanded Model for the Stepwise Evolution of Escherichia coli O157:H7 T2 - 110th General Meeting of the American Society for Microbiology AN - 839640100; 5895857 JF - 110th General Meeting of the American Society for Microbiology AU - Lacher, D AU - Mammel, M Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Evolution KW - Models KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839640100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=A+Revised+and+Expanded+Model+for+the+Stepwise+Evolution+of+Escherichia+coli+O157%3AH7&rft.au=Lacher%2C+D%3BMammel%2C+M&rft.aulast=Lacher&rft.aufirst=D&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Integration of High Resolution Genomic-Scale Technologies for Improved Strain Attribution: Examples from 2009 Foodborne Outbreaks T2 - 110th General Meeting of the American Society for Microbiology AN - 839639994; 5895871 JF - 110th General Meeting of the American Society for Microbiology AU - Patel, I AU - Jackson, S AU - Kotewicz, M AU - Hayford, A AU - Mammel, M AU - Lacher, D AU - Mukherjee, A AU - Elkins, C AU - LeClerc, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Food-borne diseases KW - Technology KW - Integration KW - Food KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Integration+of+High+Resolution+Genomic-Scale+Technologies+for+Improved+Strain+Attribution%3A+Examples+from+2009+Foodborne+Outbreaks&rft.au=Patel%2C+I%3BJackson%2C+S%3BKotewicz%2C+M%3BHayford%2C+A%3BMammel%2C+M%3BLacher%2C+D%3BMukherjee%2C+A%3BElkins%2C+C%3BLeClerc%2C+J&rft.aulast=Patel&rft.aufirst=I&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Exploring the Global Genomic Landscape of Enteric Pathogens: Genes, INDELs, SNPs-n-Chips T2 - 110th General Meeting of the American Society for Microbiology AN - 839639709; 5895881 JF - 110th General Meeting of the American Society for Microbiology AU - Jackson, S AU - Patel, I AU - Mammel, M AU - LeClerc, J Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Pathogens KW - Landscape KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Exploring+the+Global+Genomic+Landscape+of+Enteric+Pathogens%3A+Genes%2C+INDELs%2C+SNPs-n-Chips&rft.au=Jackson%2C+S%3BPatel%2C+I%3BMammel%2C+M%3BLeClerc%2C+J&rft.aulast=Jackson&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Molecular Characterization of the Somatic O-Antigen Locus of Cronobacter spp. Using PCR T2 - 110th General Meeting of the American Society for Microbiology AN - 839639226; 5894341 JF - 110th General Meeting of the American Society for Microbiology AU - Jarvis, K AU - Gopinath, G AU - Franco, A AU - Sathyamoorthy, V AU - Hu, L. AU - Lee, C AU - Sadowski, J AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Polymerase chain reaction KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Molecular+Characterization+of+the+Somatic+O-Antigen+Locus+of+Cronobacter+spp.+Using+PCR&rft.au=Jarvis%2C+K%3BGopinath%2C+G%3BFranco%2C+A%3BSathyamoorthy%2C+V%3BHu%2C+L.%3BLee%2C+C%3BSadowski%2C+J%3BTall%2C+B&rft.aulast=Jarvis&rft.aufirst=K&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Comparison of Two Molecular Methods for Serotyping Salmonella T2 - 110th General Meeting of the American Society for Microbiology AN - 839639200; 5895794 JF - 110th General Meeting of the American Society for Microbiology AU - Beaubrun, J AU - Ewing-Peeples, L AU - Kothary, M AU - Hanes, D AU - Micallef, S A AU - Rosenberg-Goldstein, R AU - George, A AU - Joseph, S AU - Sapkota, A AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Serotyping KW - Anadromous species KW - {Q2} KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Comparison+of+Two+Molecular+Methods+for+Serotyping+Salmonella&rft.au=Beaubrun%2C+J%3BEwing-Peeples%2C+L%3BKothary%2C+M%3BHanes%2C+D%3BMicallef%2C+S+A%3BRosenberg-Goldstein%2C+R%3BGeorge%2C+A%3BJoseph%2C+S%3BSapkota%2C+A%3BTall%2C+B&rft.aulast=Beaubrun&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Multi-Lab Validation of Fermentas FastDigest Enzyme for PFGE Analysis T2 - 110th General Meeting of the American Society for Microbiology AN - 839639167; 5895791 JF - 110th General Meeting of the American Society for Microbiology AU - Liu, E AU - Johnson, J AU - Van, K AU - Tran, N AU - Shen, Y Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Enzymes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Multi-Lab+Validation+of+Fermentas+FastDigest+Enzyme+for+PFGE+Analysis&rft.au=Liu%2C+E%3BJohnson%2C+J%3BVan%2C+K%3BTran%2C+N%3BShen%2C+Y&rft.aulast=Liu&rft.aufirst=E&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - PCR Analysis of Curli, Cellulose and Regulatory Genes in Cronobacter spp T2 - 110th General Meeting of the American Society for Microbiology AN - 839639129; 5894330 JF - 110th General Meeting of the American Society for Microbiology AU - Hu, L. AU - Franco, A AU - Gopinath, G AU - Kothary, M AU - Sathyamoorthy, V AU - Grim, C AU - Jarvis, K AU - Lee, C AU - Sadowski, J AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Cellulose KW - Polymerase chain reaction KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839639129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=PCR+Analysis+of+Curli%2C+Cellulose+and+Regulatory+Genes+in+Cronobacter+spp&rft.au=Hu%2C+L.%3BFranco%2C+A%3BGopinath%2C+G%3BKothary%2C+M%3BSathyamoorthy%2C+V%3BGrim%2C+C%3BJarvis%2C+K%3BLee%2C+C%3BSadowski%2C+J%3BTall%2C+B&rft.aulast=Hu&rft.aufirst=L.&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Current Concerns of Methicillin Resistant Staphylococcus aureus (MRSA) in Food Safety and Other Atypical Occurrences of Staphylococcal Food Poisoning T2 - 110th General Meeting of the American Society for Microbiology AN - 839638925; 5895787 JF - 110th General Meeting of the American Society for Microbiology AU - Hait, J AU - Bennett, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Food contamination KW - Antibiotic resistance KW - Food poisoning KW - Drug resistance KW - Methicillin KW - Public health KW - {Q2} KW - Staphylococcus aureus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839638925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Current+Concerns+of+Methicillin+Resistant+Staphylococcus+aureus+%28MRSA%29+in+Food+Safety+and+Other+Atypical+Occurrences+of+Staphylococcal+Food+Poisoning&rft.au=Hait%2C+J%3BBennett%2C+R&rft.aulast=Hait&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Isolation and Characterization of Salmonella Typhimurium DT104 Promoters that are Activated Specifically Inside Human Intestinal INT407cells. T2 - 110th General Meeting of the American Society for Microbiology AN - 839638714; 5894344 JF - 110th General Meeting of the American Society for Microbiology AU - Giri, C AU - McDaniel, J AU - Raybourne, R AU - Kopecko, D Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Intestine KW - Promoters KW - Anadromous species KW - {Q2} KW - Salmonella typhimurium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839638714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Isolation+and+Characterization+of+Salmonella+Typhimurium+DT104+Promoters+that+are+Activated+Specifically+Inside+Human+Intestinal+INT407cells.&rft.au=Giri%2C+C%3BMcDaniel%2C+J%3BRaybourne%2C+R%3BKopecko%2C+D&rft.aulast=Giri&rft.aufirst=C&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - in silico Identification and Characterization of Type 6 Secretion System in Cronobacter sakazakii and Cronobacter turicensis Genomes T2 - 110th General Meeting of the American Society for Microbiology AN - 839638662; 5894335 JF - 110th General Meeting of the American Society for Microbiology AU - Gopinath, G AU - Franco, A AU - Kothary, M AU - Jarvis, K AU - Grim, C AU - Sathyamoorthy, V AU - McCardell, B AU - Tall, B Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Secretion KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839638662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=in+silico+Identification+and+Characterization+of+Type+6+Secretion+System+in+Cronobacter+sakazakii+and+Cronobacter+turicensis+Genomes&rft.au=Gopinath%2C+G%3BFranco%2C+A%3BKothary%2C+M%3BJarvis%2C+K%3BGrim%2C+C%3BSathyamoorthy%2C+V%3BMcCardell%2C+B%3BTall%2C+B&rft.aulast=Gopinath&rft.aufirst=G&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Phylogenetic Analysis of Vibrio Isolates Associated with Deep-water Sponge (Phylum Porifera) Microcosms T2 - 110th General Meeting of the American Society for Microbiology AN - 839632254; 5894608 JF - 110th General Meeting of the American Society for Microbiology AU - Hoffmann, M AU - Monday, S AU - McCarthy, P AU - Lopez, J AU - Fischer, M AU - Brown, E Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Porifera KW - Microcosms KW - Phylogenetics KW - Marine invertebrates KW - {Q2} KW - Vibrio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839632254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Phylogenetic+Analysis+of+Vibrio+Isolates+Associated+with+Deep-water+Sponge+%28Phylum+Porifera%29+Microcosms&rft.au=Hoffmann%2C+M%3BMonday%2C+S%3BMcCarthy%2C+P%3BLopez%2C+J%3BFischer%2C+M%3BBrown%2C+E&rft.aulast=Hoffmann&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Adaptation and Validation of Real-Time Multiplex PCR for the Screening of Shiga Toxin-producing Escherichia coli (STEC) to a High-Throughput Platform T2 - 110th General Meeting of the American Society for Microbiology AN - 839631349; 5894646 JF - 110th General Meeting of the American Society for Microbiology AU - Waite, J AU - Jinneman, K AU - Yoshitomi, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Adaptability KW - Adaptations KW - Polymerase chain reaction KW - Screening KW - Nucleotide sequence KW - {Q2} KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839631349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Adaptation+and+Validation+of+Real-Time+Multiplex+PCR+for+the+Screening+of+Shiga+Toxin-producing+Escherichia+coli+%28STEC%29+to+a+High-Throughput+Platform&rft.au=Waite%2C+J%3BJinneman%2C+K%3BYoshitomi%2C+K&rft.aulast=Waite&rft.aufirst=J&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Evaluation of Rapid Microbial Methods for Testing Sterility of Biological Products T2 - 110th General Meeting of the American Society for Microbiology AN - 839631172; 5894556 JF - 110th General Meeting of the American Society for Microbiology AU - Parveen, S AU - Kaur, S AU - Kenney, J AU - McCormick, W AU - Gupta, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Sterility KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839631172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evaluation+of+Rapid+Microbial+Methods+for+Testing+Sterility+of+Biological+Products&rft.au=Parveen%2C+S%3BKaur%2C+S%3BKenney%2C+J%3BMcCormick%2C+W%3BGupta%2C+R&rft.aulast=Parveen&rft.aufirst=S&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - MAPREC Assay for Quantification of Virulent Mutations in Live Poliovirus Vaccine Based on Near-infrared Fluorescence Detection. T2 - 110th General Meeting of the American Society for Microbiology AN - 839630813; 5894719 JF - 110th General Meeting of the American Society for Microbiology AU - Bidzhieva, B AU - Laassri, M AU - Chumakov, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Vaccines KW - Mutation KW - Poliovirus KW - Fluorescence KW - I.R. radiation KW - Disease control KW - {Q2} KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839630813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=MAPREC+Assay+for+Quantification+of+Virulent+Mutations+in+Live+Poliovirus+Vaccine+Based+on+Near-infrared+Fluorescence+Detection.&rft.au=Bidzhieva%2C+B%3BLaassri%2C+M%3BChumakov%2C+K&rft.aulast=Bidzhieva&rft.aufirst=B&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Evaluation of Mycoplasmas Inactivation by Chemical Agents used in Production of Egg-Based Influenza Viral Vaccines (Inactivated) T2 - 110th General Meeting of the American Society for Microbiology AN - 839630748; 5894726 JF - 110th General Meeting of the American Society for Microbiology AU - Wilson David, S. AU - Volokhov, D AU - Zhiping, Y AU - Chizhikov, V Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Vaccines KW - Inactivation KW - Influenza KW - Disease control KW - {Q2} KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839630748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Evaluation+of+Mycoplasmas+Inactivation+by+Chemical+Agents+used+in+Production+of+Egg-Based+Influenza+Viral+Vaccines+%28Inactivated%29&rft.au=Wilson+David%2C+S.%3BVolokhov%2C+D%3BZhiping%2C+Y%3BChizhikov%2C+V&rft.aulast=Wilson+David&rft.aufirst=S.&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Vaccine Potential of Shigella Bacterial Ghosts T2 - 110th General Meeting of the American Society for Microbiology AN - 839630425; 5894480 JF - 110th General Meeting of the American Society for Microbiology AU - Osorio, M AU - Filippova, S AU - Kopecko, D AU - Walker, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Vaccines KW - Disease control KW - {Q2} KW - Shigella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839630425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Vaccine+Potential+of+Shigella+Bacterial+Ghosts&rft.au=Osorio%2C+M%3BFilippova%2C+S%3BKopecko%2C+D%3BWalker%2C+R&rft.aulast=Osorio&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Characterization of Leishmania amastigote Specific Mitochondrial Membrane Protein: Its Role in Virulence T2 - 110th General Meeting of the American Society for Microbiology AN - 839630216; 5894791 JF - 110th General Meeting of the American Society for Microbiology AU - Dey, R AU - Salotra, P AU - Nakhasi, H AU - Duncan, R Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Membrane proteins KW - Virulence KW - Mitochondria KW - Amastigotes KW - {Q2} KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839630216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Characterization+of+Leishmania+amastigote+Specific+Mitochondrial+Membrane+Protein%3A+Its+Role+in+Virulence&rft.au=Dey%2C+R%3BSalotra%2C+P%3BNakhasi%2C+H%3BDuncan%2C+R&rft.aulast=Dey&rft.aufirst=R&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Genetic Stability Assessment of West Nile/Dengue 4 Virus Chimeras T2 - 110th General Meeting of the American Society for Microbiology AN - 839630044; 5894720 JF - 110th General Meeting of the American Society for Microbiology AU - Laassri, M AU - Bidzhieva, B AU - Pletnev, A AU - Chumakov, K Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Dengue KW - Chimeras KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839630044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=Genetic+Stability+Assessment+of+West+Nile%2FDengue+4+Virus+Chimeras&rft.au=Laassri%2C+M%3BBidzhieva%2C+B%3BPletnev%2C+A%3BChumakov%2C+K&rft.aulast=Laassri&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - The Effects of Contact Lens and Lens Cases on Disinfection Activity in Multipurpose Contact Lens Solution against S. aureus T2 - 110th General Meeting of the American Society for Microbiology AN - 839628248; 5894552 JF - 110th General Meeting of the American Society for Microbiology AU - Shoff, M AU - Brown, J AU - Lucas, A AU - Hitchins, V Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - {Q1} KW - Disinfection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839628248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.atitle=The+Effects+of+Contact+Lens+and+Lens+Cases+on+Disinfection+Activity+in+Multipurpose+Contact+Lens+Solution+against+S.+aureus&rft.au=Shoff%2C+M%3BBrown%2C+J%3BLucas%2C+A%3BHitchins%2C+V&rft.aulast=Shoff&rft.aufirst=M&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=110th+General+Meeting+of+the+American+Society+for+Microbiology&rft.issn=&rft_id=info:doi/ L2 - http://gm.asm.org/images/stories/final_gm_final_program-v2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CPAPER T1 - Facility Controlled Environments T2 - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AN - 754268586; 5805753 JF - 16th Annual Meeting of the International Society for Cellular Therapy (ISCT 2010) AU - Wang, Gang AU - Heimfeld, Shelly Y1 - 2010/05/23/ PY - 2010 DA - 2010 May 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.atitle=Facility+Controlled+Environments&rft.au=Wang%2C+Gang%3BHeimfeld%2C+Shelly&rft.aulast=Wang&rft.aufirst=Gang&rft.date=2010-05-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+Meeting+of+the+International+Society+for+Cellular+Therapy+%28ISCT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.celltherapy2010.com/uploads/ISCT_2010_GRP_Program_Draft.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Comparison of Air Sampling Methods for Aerosolized B. Anthracis Sterne T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754257666; 5779603 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Estill, C AU - Baron, P AU - Hein, M AU - Deye, G AU - Beard, J AU - Larsen, L Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Air sampling KW - Sampling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Comparison+of+Air+Sampling+Methods+for+Aerosolized+B.+Anthracis+Sterne&rft.au=Estill%2C+C%3BBaron%2C+P%3BHein%2C+M%3BDeye%2C+G%3BBeard%2C+J%3BLarsen%2C+L&rft.aulast=Estill&rft.aufirst=C&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Update of the NIOSH IDLH Values Using the Modern Principles of Risk Assessment T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754257000; 5779837 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Dotson, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Risk assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Update+of+the+NIOSH+IDLH+Values+Using+the+Modern+Principles+of+Risk+Assessment&rft.au=Dotson%2C+S&rft.aulast=Dotson&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of High Flow Rate Samplers for Respirable Particles T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754256427; 5779663 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Lee, T AU - Kim, S AU - Chisholm, W AU - Harper, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Particulates KW - Flow rates KW - Samplers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Evaluation+of+High+Flow+Rate+Samplers+for+Respirable+Particles&rft.au=Lee%2C+T%3BKim%2C+S%3BChisholm%2C+W%3BHarper%2C+M&rft.aulast=Lee&rft.aufirst=T&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Oil and Gas Extraction Program T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754247020; 5779584 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Esswein, E Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Oil and gas industry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754247020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Oil+and+Gas+Extraction+Program&rft.au=Esswein%2C+E&rft.aulast=Esswein&rft.aufirst=E&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - N95 Respirator and Surgical Mask Efficacy for Cough Aerosols T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754246953; 5779504 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Szalajda, J AU - King, W AU - Reynolds, J AU - Lindsley, W Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Surgery KW - Respirators KW - Aerosols KW - Protective equipment KW - Cough KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=N95+Respirator+and+Surgical+Mask+Efficacy+for+Cough+Aerosols&rft.au=Szalajda%2C+J%3BKing%2C+W%3BReynolds%2C+J%3BLindsley%2C+W&rft.aulast=Szalajda&rft.aufirst=J&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Spray Polyurethane Foam (SPF) Insulation Case Study: Potential for Construction Worker Exposures and Concerns T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754246921; 5779497 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Almaguer, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Case studies KW - Construction industry KW - Sprays KW - Occupational exposure KW - Polyurethane KW - Foams KW - Insulating materials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Spray+Polyurethane+Foam+%28SPF%29+Insulation+Case+Study%3A+Potential+for+Construction+Worker+Exposures+and+Concerns&rft.au=Almaguer%2C+D&rft.aulast=Almaguer&rft.aufirst=D&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Release of Beryllium from Poorly Soluble Particulate in Artificial Sweat T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754246552; 5779817 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Stefaniak, A AU - Virji, M AU - Day, G Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Particulates KW - Beryllium KW - Sweat KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Release+of+Beryllium+from+Poorly+Soluble+Particulate+in+Artificial+Sweat&rft.au=Stefaniak%2C+A%3BVirji%2C+M%3BDay%2C+G&rft.aulast=Stefaniak&rft.aufirst=A&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Using the Tools of Social Media to Engage and Provide Reliable Safety and Health Information to Public and Professional Audiences: Is Myspace Really Our Space? T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754246082; 5779690 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Lum, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Public health KW - Health and safety KW - Experts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754246082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Using+the+Tools+of+Social+Media+to+Engage+and+Provide+Reliable+Safety+and+Health+Information+to+Public+and+Professional+Audiences%3A+Is+Myspace+Really+Our+Space%3F&rft.au=Lum%2C+M&rft.aulast=Lum&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Effect of Biological Decontamination Methods on Filtering Facepiece Respirator Fit. T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754244323; 5779981 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Viscusi, D AU - Shaffer, R AU - Faulkner, K AU - Bergman, M AU - Palmiero, A AU - Powell, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Decontamination KW - Respirators KW - Protective equipment KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754244323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Effect+of+Biological+Decontamination+Methods+on+Filtering+Facepiece+Respirator+Fit.&rft.au=Viscusi%2C+D%3BShaffer%2C+R%3BFaulkner%2C+K%3BBergman%2C+M%3BPalmiero%2C+A%3BPowell%2C+J&rft.aulast=Viscusi&rft.aufirst=D&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Emissions and Exposure Monitoring during Carbon Nanofiber Production T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754244264; 5779976 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Evans, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Emissions KW - Carbon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754244264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Emissions+and+Exposure+Monitoring+during+Carbon+Nanofiber+Production&rft.au=Evans%2C+D&rft.aulast=Evans&rft.aufirst=D&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of Composting Toilet Cleaning and Maintenance T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754244228; 5779961 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Burton, N AU - Dowell, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Recycling KW - Waste management KW - Composting KW - Toilets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754244228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Evaluation+of+Composting+Toilet+Cleaning+and+Maintenance&rft.au=Burton%2C+N%3BDowell%2C+C&rft.aulast=Burton&rft.aufirst=N&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Making Green Jobs Safe: Integrating Worker Health and Safety into Sustainability T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754243471; 5779494 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Heidel, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Green development KW - Sustainability KW - Resource management KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754243471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Making+Green+Jobs+Safe%3A+Integrating+Worker+Health+and+Safety+into+Sustainability&rft.au=Heidel%2C+D&rft.aulast=Heidel&rft.aufirst=D&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Analytical Method for the Detection of Diacetyl and Other Food Flavoring Compounds in Powders T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754242872; 5779766 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Nourian, F Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Flavorings KW - Diacetyl KW - Powder KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Analytical+Method+for+the+Detection+of+Diacetyl+and+Other+Food+Flavoring+Compounds+in+Powders&rft.au=Nourian%2C+F&rft.aulast=Nourian&rft.aufirst=F&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Implementing NORA Goals T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754242407; 5779583 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Gillen, M AU - Schneider, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Implementing+NORA+Goals&rft.au=Gillen%2C+M%3BSchneider%2C+S&rft.aulast=Gillen&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Laboratory Study to Assess Causative Factors Affecting Temporal Changes in Filtering Facepiece Respirator Fit, Part I: Study Protocol T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754242081; 5779507 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Zhuang, Z AU - Lynch, S AU - Roberge, R AU - Benson, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Respirators KW - Protective equipment KW - Respiration KW - Temporal variations KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754242081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Laboratory+Study+to+Assess+Causative+Factors+Affecting+Temporal+Changes+in+Filtering+Facepiece+Respirator+Fit%2C+Part+I%3A+Study+Protocol&rft.au=Zhuang%2C+Z%3BLynch%2C+S%3BRoberge%2C+R%3BBenson%2C+S&rft.aulast=Zhuang&rft.aufirst=Z&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Do my Tasks add up? Task Based Noise Versus Full Shift Assessment Approaches. T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754241953; 5779477 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Virji, A Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Do+my+Tasks+add+up%3F+Task+Based+Noise+Versus+Full+Shift+Assessment+Approaches.&rft.au=Virji%2C+A&rft.aulast=Virji&rft.aufirst=A&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Respiratory Protection Guidelines and Recommendations T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754241514; 5779743 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Berry Ann, R. Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Guidelines KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Respiratory+Protection+Guidelines+and+Recommendations&rft.au=Berry+Ann%2C+R.&rft.aulast=Berry+Ann&rft.aufirst=R.&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of Potential Exposures at a Printed Circuit Board Manufacturing Plant T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754240900; 5779444 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Durgam, S AU - Achutan, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Manufacturing industry KW - Circuits KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754240900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Evaluation+of+Potential+Exposures+at+a+Printed+Circuit+Board+Manufacturing+Plant&rft.au=Durgam%2C+S%3BAchutan%2C+C&rft.aulast=Durgam&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Fiber Examination Using Different Mounting Methods for Phase Contrast Microscopy T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236510; 5779929 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Lee, E AU - Harper, M AU - Nelson, J AU - Andrew, M AU - Hintz, P AU - Joy, G AU - Pang, T Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Fibers KW - Microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Fiber+Examination+Using+Different+Mounting+Methods+for+Phase+Contrast+Microscopy&rft.au=Lee%2C+E%3BHarper%2C+M%3BNelson%2C+J%3BAndrew%2C+M%3BHintz%2C+P%3BJoy%2C+G%3BPang%2C+T&rft.aulast=Lee&rft.aufirst=E&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Wind-Driven Method to Assessing Nano- and Submicron Particle Penetration through Fabrics T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236416; 5779978 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Gao, P AU - Shaffer, R AU - Yang, M AU - Shepherd, A AU - Jaques, P Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Particulates KW - Fabrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=A+Wind-Driven+Method+to+Assessing+Nano-+and+Submicron+Particle+Penetration+through+Fabrics&rft.au=Gao%2C+P%3BShaffer%2C+R%3BYang%2C+M%3BShepherd%2C+A%3BJaques%2C+P&rft.aulast=Gao&rft.aufirst=P&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Chemical Exposure Control in the Biodiesel Industry T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236373; 5779967 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Law, B AU - Pearce, T AU - Siegel, P Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Biofuels KW - Diesel KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Chemical+Exposure+Control+in+the+Biodiesel+Industry&rft.au=Law%2C+B%3BPearce%2C+T%3BSiegel%2C+P&rft.aulast=Law&rft.aufirst=B&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Guidance for Solid Waste Cleanup Along the U.S.-Mexico Border T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236314; 5779966 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Niemeier, R Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Solid wastes KW - Solid impurities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Guidance+for+Solid+Waste+Cleanup+Along+the+U.S.-Mexico+Border&rft.au=Niemeier%2C+R&rft.aulast=Niemeier&rft.aufirst=R&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of Carbon Monoxide Exposure among Airport Cargo Material Handlers T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236271; 5779963 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Dowell, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Carbon monoxide KW - Airports KW - Handlers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Evaluation+of+Carbon+Monoxide+Exposure+among+Airport+Cargo+Material+Handlers&rft.au=Dowell%2C+C&rft.aulast=Dowell&rft.aufirst=C&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NIOSH Assessment of Occupational Exposures to Glutaraldehyde T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754236185; 5779951 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Jacklitsch, B AU - Dotson, G AU - Dankovic, D AU - MacMahon, K AU - Hodson, L Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Occupational exposure KW - Glutaraldehyde KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=NIOSH+Assessment+of+Occupational+Exposures+to+Glutaraldehyde&rft.au=Jacklitsch%2C+B%3BDotson%2C+G%3BDankovic%2C+D%3BMacMahon%2C+K%3BHodson%2C+L&rft.aulast=Jacklitsch&rft.aufirst=B&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Recommended Methodology for Evaluating Metalworking Fluid Exposures T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754235986; 5779947 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Rodriguez, M AU - Burton, N AU - Tapp, L AU - Eisenberg, J AU - Evans, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Metal-working fluids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Recommended+Methodology+for+Evaluating+Metalworking+Fluid+Exposures&rft.au=Rodriguez%2C+M%3BBurton%2C+N%3BTapp%2C+L%3BEisenberg%2C+J%3BEvans%2C+S&rft.aulast=Rodriguez&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Dust and Soy Antigen Exposures at a Soy Processing Plant T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754235774; 5779946 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Boylstein, R AU - Kullman, G AU - Cummings, K AU - Gaughan, D AU - Piacitelli, C AU - Beezhold, D AU - Green, B AU - Blachere, F AU - Bledsoe, T AU - Cox-Ganser, J AU - Kreiss, K Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Dust KW - Soybeans KW - Antigen processing KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Dust+and+Soy+Antigen+Exposures+at+a+Soy+Processing+Plant&rft.au=Boylstein%2C+R%3BKullman%2C+G%3BCummings%2C+K%3BGaughan%2C+D%3BPiacitelli%2C+C%3BBeezhold%2C+D%3BGreen%2C+B%3BBlachere%2C+F%3BBledsoe%2C+T%3BCox-Ganser%2C+J%3BKreiss%2C+K&rft.aulast=Boylstein&rft.aufirst=R&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Air and Real-Time Diacetyl Exposure Assessment at a Flavoring and Modified Dairy Product Manufacturing Plant T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754235707; 5779944 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Saito, R AU - Piacitelli, C AU - Boylstein, R AU - Kanwal, R AU - Sahakian, N AU - Kullman, G Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Dairy products KW - Manufacturing industry KW - Flavorings KW - Diacetyl KW - Air exposure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Air+and+Real-Time+Diacetyl+Exposure+Assessment+at+a+Flavoring+and+Modified+Dairy+Product+Manufacturing+Plant&rft.au=Saito%2C+R%3BPiacitelli%2C+C%3BBoylstein%2C+R%3BKanwal%2C+R%3BSahakian%2C+N%3BKullman%2C+G&rft.aulast=Saito&rft.aufirst=R&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Bromide and N-acetyl-s-(n-propyl)-l-cysteine in Urine From Workers Exposed to 1-Bromopropane Solvents from Vapor Degreasing T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754235353; 5779938 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Hanley, K AU - Petersen, M AU - Cheever, K AU - Luo, L Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Cleaning process KW - Solvents KW - Vapors KW - Urine KW - Bromides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Bromide+and+N-acetyl-s-%28n-propyl%29-l-cysteine+in+Urine+From+Workers+Exposed+to+1-Bromopropane+Solvents+from+Vapor+Degreasing&rft.au=Hanley%2C+K%3BPetersen%2C+M%3BCheever%2C+K%3BLuo%2C+L&rft.aulast=Hanley&rft.aufirst=K&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Identification and Quantitative Analysis of Wood Dust by Direct On-Filter Diffuse Reflectance T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754235183; 5779935 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Harper, M AU - Chirila, M AU - Lee, T AU - Flemmer, M AU - Slaven, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Dust KW - Wood KW - Quantitative analysis KW - Reflectance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754235183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Identification+and+Quantitative+Analysis+of+Wood+Dust+by+Direct+On-Filter+Diffuse+Reflectance&rft.au=Harper%2C+M%3BChirila%2C+M%3BLee%2C+T%3BFlemmer%2C+M%3BSlaven%2C+J&rft.aulast=Harper&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Evaluation of Potential Chemical Hazards in the Criminal Investigation Section of a Police Department T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754234802; 5779927 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Fent, K AU - Almazan, A Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Police KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Evaluation+of+Potential+Chemical+Hazards+in+the+Criminal+Investigation+Section+of+a+Police+Department&rft.au=Fent%2C+K%3BAlmazan%2C+A&rft.aulast=Fent&rft.aufirst=K&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Transportation, Warehousing, and Utilities T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754234704; 5779585 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Kiefer, M AU - Mokadam, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Utilities KW - Transportation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Transportation%2C+Warehousing%2C+and+Utilities&rft.au=Kiefer%2C+M%3BMokadam%2C+D&rft.aulast=Kiefer&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Performance of Air-Purifying Respirators with and without End-of-Service-Life Indicators (ESLI) against Diacetyl T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754234564; 5779502 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Parker, J AU - Snyder, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Respirators KW - Protective equipment KW - Diacetyl KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Performance+of+Air-Purifying+Respirators+with+and+without+End-of-Service-Life+Indicators+%28ESLI%29+against+Diacetyl&rft.au=Parker%2C+J%3BSnyder%2C+J&rft.aulast=Parker&rft.aufirst=J&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Aerosol Transmission: Current Knowledge and Ongoing Research T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754234251; 5779908 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Szalajda, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Aerosols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Aerosol+Transmission%3A+Current+Knowledge+and+Ongoing+Research&rft.au=Szalajda%2C+J&rft.aulast=Szalajda&rft.aufirst=J&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Overview of 2009 H1N1 Influenza T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754234144; 5779741 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Delaney, L Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Influenza KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Overview+of+2009+H1N1+Influenza&rft.au=Delaney%2C+L&rft.aulast=Delaney&rft.aufirst=L&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Respiratory Conditions and Diseases, and Cancer Due to Exposures T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754229898; 5779579 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Lotz, W AU - Talaska, G Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Cancer KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754229898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Respiratory+Conditions+and+Diseases%2C+and+Cancer+Due+to+Exposures&rft.au=Lotz%2C+W%3BTalaska%2C+G&rft.aulast=Lotz&rft.aufirst=W&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Injuries and Fatalities Due to Contact with Objects/Equipment and Falls T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754229686; 5779576 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Renshaw, F Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Mortality KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754229686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Injuries+and+Fatalities+Due+to+Contact+with+Objects%2FEquipment+and+Falls&rft.au=Renshaw%2C+F&rft.aulast=Renshaw&rft.aufirst=F&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Occupational Safety and Health Programs T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754229638; 5779575 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Boiano, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Occupational safety KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754229638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Occupational+Safety+and+Health+Programs&rft.au=Boiano%2C+J&rft.aulast=Boiano&rft.aufirst=J&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NIOSH Research to Practice (r2p) Solutions for NORA Construction Goals T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754229137; 5779564 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Echt, A Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754229137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=NIOSH+Research+to+Practice+%28r2p%29+Solutions+for+NORA+Construction+Goals&rft.au=Echt%2C+A&rft.aulast=Echt&rft.aufirst=A&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NIOSH Welding Hexavalent Chromium Fume Generation Study Results by Process T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228797; 5779652 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Keane, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Welding KW - Fumes KW - Chromium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=NIOSH+Welding+Hexavalent+Chromium+Fume+Generation+Study+Results+by+Process&rft.au=Keane%2C+M&rft.aulast=Keane&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Determination of Low-level Volatile Organic Compound Profiles in Health-Care Settings T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228621; 5779555 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - LeBouf, R AU - Stefaniak, A AU - Virji, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Volatile organic compounds KW - Organic compounds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Determination+of+Low-level+Volatile+Organic+Compound+Profiles+in+Health-Care+Settings&rft.au=LeBouf%2C+R%3BStefaniak%2C+A%3BVirji%2C+M&rft.aulast=LeBouf&rft.aufirst=R&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Overview of Experiences from the Field T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228338; 5779549 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Methner, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Overview+of+Experiences+from+the+Field&rft.au=Methner%2C+M&rft.aulast=Methner&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Update on NIOSH Research on Respiratory Protection and Personal Protective Clothing Specific to Engineered Nanomaterials T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228278; 5779548 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Shaffer, R Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Protective clothing KW - Nanotechnology KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=An+Update+on+NIOSH+Research+on+Respiratory+Protection+and+Personal+Protective+Clothing+Specific+to+Engineered+Nanomaterials&rft.au=Shaffer%2C+R&rft.aulast=Shaffer&rft.aufirst=R&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Update on NIOSH Research Focused in Instrumental Detection of Nanomaterials T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228229; 5779547 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Evans, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=An+Update+on+NIOSH+Research+Focused+in+Instrumental+Detection+of+Nanomaterials&rft.au=Evans%2C+D&rft.aulast=Evans&rft.aufirst=D&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Update of the NIOSH Effort in Nanomaterial Surveillance T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228171; 5779546 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Geraci, Jr, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=An+Update+of+the+NIOSH+Effort+in+Nanomaterial+Surveillance&rft.au=Geraci%2C+Jr%2C+C&rft.aulast=Geraci&rft.aufirst=Jr&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - An Update of the NIOSH Nanotechnology Research Program T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754228155; 5779545 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Geraci, Jr, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Nanotechnology KW - Research programs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754228155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=An+Update+of+the+NIOSH+Nanotechnology+Research+Program&rft.au=Geraci%2C+Jr%2C+C&rft.aulast=Geraci&rft.aufirst=Jr&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Update of the New NIOSH Skin Notation Project: Lessons Learned and Future Plans T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754227188; 5779756 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Dotson, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754227188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Update+of+the+New+NIOSH+Skin+Notation+Project%3A+Lessons+Learned+and+Future+Plans&rft.au=Dotson%2C+S&rft.aulast=Dotson&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Addressing Research Gaps in the NIOSH Skin Notation Project: The Example of 1-Bromopropane T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754226895; 5779758 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Frasch, H Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Addressing+Research+Gaps+in+the+NIOSH+Skin+Notation+Project%3A+The+Example+of+1-Bromopropane&rft.au=Frasch%2C+H&rft.aulast=Frasch&rft.aufirst=H&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - NIOSH Health Hazard Evaluation in Utah Hospitals: Challenges to Protecting Health-Care Workers from the 2009 H1N1 Influenza Virus. T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754226652; 5779742 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Brueck, S Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - USA, Utah KW - Hospitals KW - Influenza KW - Public health KW - Influenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=NIOSH+Health+Hazard+Evaluation+in+Utah+Hospitals%3A+Challenges+to+Protecting+Health-Care+Workers+from+the+2009+H1N1+Influenza+Virus.&rft.au=Brueck%2C+S&rft.aulast=Brueck&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Expedient Airborne Isolation for Health-Care Facilities During Emergency Epidemic Response T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754226597; 5779407 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Mead, K Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Epidemics KW - Emergencies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Expedient+Airborne+Isolation+for+Health-Care+Facilities+During+Emergency+Epidemic+Response&rft.au=Mead%2C+K&rft.aulast=Mead&rft.aufirst=K&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Demand and Opportunities for Occupational Safety and Health Education in Egypt T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754226485; 5779383 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Lum, M AU - Rinehart, R Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Egypt, Arab Rep. KW - Education KW - Occupational safety KW - Health and safety KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Demand+and+Opportunities+for+Occupational+Safety+and+Health+Education+in+Egypt&rft.au=Lum%2C+M%3BRinehart%2C+R&rft.aulast=Lum&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Gathering and Delivering Noise Level Information for "Buy Quiet." T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754225455; 5779892 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Hayden, C Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Noise levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754225455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Gathering+and+Delivering+Noise+Level+Information+for+%22Buy+Quiet.%22&rft.au=Hayden%2C+C&rft.aulast=Hayden&rft.aufirst=C&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Wholesale and Retail Trade T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754223629; 5779582 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Anderson, V Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Wholesale+and+Retail+Trade&rft.au=Anderson%2C+V&rft.aulast=Anderson&rft.aufirst=V&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Interlaboratory Evaluation of a Standardized Inductively Coupled Plasma Mass Spectrometry Method for the Determination of Trace Elements in Air Filter Samples T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754222831; 5779768 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Ashley, K AU - Brisson, M AU - Howe, A Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Mass spectroscopy KW - Pollutant removal KW - Standards KW - Trace elements KW - Air purification KW - Filters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Interlaboratory+Evaluation+of+a+Standardized+Inductively+Coupled+Plasma+Mass+Spectrometry+Method+for+the+Determination+of+Trace+Elements+in+Air+Filter+Samples&rft.au=Ashley%2C+K%3BBrisson%2C+M%3BHowe%2C+A&rft.aulast=Ashley&rft.aufirst=K&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Respirator Use Surveillance in Health-Care T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754222351; 5779408 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - D'Alessandro, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Respirators KW - Protective equipment KW - Respiration KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754222351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Respirator+Use+Surveillance+in+Health-Care&rft.au=D%27Alessandro%2C+M&rft.aulast=D%27Alessandro&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - 1-Bromopropane Exposure in Dry Cleaning Establishments T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754221133; 5779962 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Ramsey, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=1-Bromopropane+Exposure+in+Dry+Cleaning+Establishments&rft.au=Ramsey%2C+J&rft.aulast=Ramsey&rft.aufirst=J&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Validating Leading and Lagging OSH Indicators T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754219541; 5779848 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Wurzelbacher, S AU - Jin, Y Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Validating+Leading+and+Lagging+OSH+Indicators&rft.au=Wurzelbacher%2C+S%3BJin%2C+Y&rft.aulast=Wurzelbacher&rft.aufirst=S&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Engineering Control Assessment for Liquid and Powder Flavorings T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754219045; 5779888 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Garcia, A AU - Hirst, D Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Flavorings KW - Powder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754219045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Engineering+Control+Assessment+for+Liquid+and+Powder+Flavorings&rft.au=Garcia%2C+A%3BHirst%2C+D&rft.aulast=Garcia&rft.aufirst=A&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Growing View of the "Exposome" T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754216408; 5779614 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Hoover, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754216408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=The+Growing+View+of+the+%22Exposome%22&rft.au=Hoover%2C+M&rft.aulast=Hoover&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pandemic Preparedness and Response in the Albuquerque Area of the Indian Health Service T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754216354; 5779608 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Hroch, B Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - USA, New Mexico, Albuquerque KW - Pandemics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754216354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Pandemic+Preparedness+and+Response+in+the+Albuquerque+Area+of+the+Indian+Health+Service&rft.au=Hroch%2C+B&rft.aulast=Hroch&rft.aufirst=B&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Geologic and Toxicologic Factors That Determine the Potential Hazards of Naturally Occurring Asbestos T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754215578; 5779753 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Harper, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Geology KW - Asbestos KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754215578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Geologic+and+Toxicologic+Factors+That+Determine+the+Potential+Hazards+of+Naturally+Occurring+Asbestos&rft.au=Harper%2C+M&rft.aulast=Harper&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Field Evaluation of Different Large Particle Samplers for Wood Dust T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754215094; 5779665 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Harper, M AU - Lee, T AU - Slaven, J Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Particulates KW - Dust KW - Wood KW - Samplers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754215094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=Field+Evaluation+of+Different+Large+Particle+Samplers+for+Wood+Dust&rft.au=Harper%2C+M%3BLee%2C+T%3BSlaven%2C+J&rft.aulast=Harper&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - H1N1 (A) 2009 as an Example of Emerging Infectious Disease Epidemiology T2 - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AN - 754214746; 5779405 JF - 2010 Conference and Exposition of the American Industrial Hygiene Association (AIHce 2010) AU - Waters, M Y1 - 2010/05/22/ PY - 2010 DA - 2010 May 22 KW - Infectious diseases KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754214746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.atitle=H1N1+%28A%29+2009+as+an+Example+of+Emerging+Infectious+Disease+Epidemiology&rft.au=Waters%2C+M&rft.aulast=Waters&rft.aufirst=M&rft.date=2010-05-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Conference+and+Exposition+of+the+American+Industrial+Hygiene+Association+%28AIHce+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aihce2010.org/aihce10/pdf/FP.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Persistent Growth of a Human Plasma-Derived Hepatitis C Virus Genotype 1b Isolate in Cell Culture AN - 745938948; 13083270 AB - HCV (hepatitis C virus) research, including therapeutics and vaccine development, has been hampered by the lack of suitable tissue culture models. Development of cell culture systems for the growth of the most drug-resistant HCV genotype (1b) as well as natural isolates has remained a challenge. Transfection of cultured cells with adenovirus-associated RNAI (VA RNAI), a known interferon (IFN) antagonist and inhibitor of dsRNA-mediated antiviral pathways, enhanced the growth of plasma-derived HCV genotype 1b. Furthermore, persistent viral growth was achieved after passaging through IFN-a/b-deficient VeroE6 cells for 2 years. Persistently infected cells were maintained in culture for an additional 4 years, and the virus rescued from these cells induced strong cytopathic effect (CPE). Using a CPE-based assay, we measured inhibition of viral production by anti-HCV specific inhibitors, including 2'-C-Methyl-D-Adenosine, demonstrating its utility for the evaluation of HCV antivirals. This virus constitutes a novel tool for the study of one of the most relevant strains of HCV, genotype 1b, which will now be available for HCV life cycle research and useful for the development of new therapeutics. Hepatitis C virus (HCV) causes a persistent infection that can lead to hepatocellular carcinoma and liver cirrhosis. Interferon (IFN)-based treatments are ineffective for some HCV genotypes. HCV research has been hampered by the lack of suitable cell culture systems. With the discovery of a unique HCV genotype 2a isolate that can replicate in the human liver cell line Huh7, some obstacles were overcome. However, there remains the need of systems to grow IFN-resistant genotypes and serum-derived isolates. Here we show that the presence of adenovirus-associated RNAI (VA RNAI), a known IFN antagonist, permitted establishment of a persistent infection of genotype 1b in VeroE6 cells that were passaged weekly for more than 2 years. The persistent virus induces strong cytopathic effect (CPE), a feature that allowed the development of a CPE-based assay to test HCV-specific inhibitors, neutralization by anti-HCV immunoglobulins and by anti-CD81 antibody, and HCV-specific siRNA. Our system provides the first persistent culture of genotype 1b virus and a convenient assay that can be used for therapeutics development. JF - PLoS Pathogens AU - Silberstein, Erica AU - Mihalik, Kathleen AU - Ulitzky, Laura AU - Plant, Ewan P AU - Puig, Montserrat AU - Gagneten, Sara AU - Yu, Mei-ying W AU - Kaushik-Basu, Neerja AU - Feinstone, Stephen M AU - Taylor, Deborah R AD - Division of Emerging and Transfusion-transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America Y1 - 2010/05/20/ PY - 2010 DA - 2010 May 20 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 USA VL - 6 IS - 5 SN - 1553-7366, 1553-7366 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Cirrhosis KW - Hepatocytes KW - Drug resistance KW - Life cycle KW - Drug development KW - Cell culture KW - Genotypes KW - Tissue culture KW - Pathogens KW - Persistent infection KW - Interferon KW - Hepatitis C virus KW - siRNA KW - Transfection KW - RNA-mediated interference KW - Vaccines KW - a-Interferon KW - Immunoglobulins KW - Hepatocellular carcinoma KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745938948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Persistent+Growth+of+a+Human+Plasma-Derived+Hepatitis+C+Virus+Genotype+1b+Isolate+in+Cell+Culture&rft.au=Silberstein%2C+Erica%3BMihalik%2C+Kathleen%3BUlitzky%2C+Laura%3BPlant%2C+Ewan+P%3BPuig%2C+Montserrat%3BGagneten%2C+Sara%3BYu%2C+Mei-ying+W%3BKaushik-Basu%2C+Neerja%3BFeinstone%2C+Stephen+M%3BTaylor%2C+Deborah+R&rft.aulast=Silberstein&rft.aufirst=Erica&rft.date=2010-05-20&rft.volume=6&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.1000910 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2013-05-31 N1 - SubjectsTermNotLitGenreText - Cirrhosis; Hepatocytes; Drug resistance; Life cycle; Cell culture; Drug development; Pathogens; Tissue culture; Genotypes; Persistent infection; Interferon; siRNA; Transfection; RNA-mediated interference; Vaccines; a-Interferon; Hepatocellular carcinoma; Immunoglobulins; Hepatitis C virus DO - http://dx.doi.org/10.1371/journal.ppat.1000910 ER - TY - CPAPER T1 - Recovery Act Funding for Comparative Effectiveness Research T2 - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AN - 754234401; 5795410 JF - Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke 2010 Scientific Sessions AU - Conway, Patrick Y1 - 2010/05/19/ PY - 2010 DA - 2010 May 19 KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754234401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.atitle=Recovery+Act+Funding+for+Comparative+Effectiveness+Research&rft.au=Conway%2C+Patrick&rft.aulast=Conway&rft.aufirst=Patrick&rft.date=2010-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Quality+of+Care+and+Outcomes+Research+in+Cardiovascular+Disease+and+Stroke+2010+Scientific+Sessions&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1272405119904KB-0003%2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Challenges of Reviewing Biologic Products - a Clinical Pharmacology Perspective T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754271799; 5815087 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Zhao, Hong Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754271799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Regulatory+Challenges+of+Reviewing+Biologic+Products+-+a+Clinical+Pharmacology+Perspective&rft.au=Zhao%2C+Hong&rft.aulast=Zhao&rft.aufirst=Hong&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pharmacologic-based Risk Prediction - A New Approach to Complement to Pharmacoepidemiology T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754270571; 5814971 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Abernethy, Darrell AU - Lesko, Lawrence Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754270571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Pharmacologic-based+Risk+Prediction+-+A+New+Approach+to+Complement+to+Pharmacoepidemiology&rft.au=Abernethy%2C+Darrell%3BLesko%2C+Lawrence&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Integration of Pharmacometrics in Oncology Drug Development: FDA Perspective T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754269767; 5815084 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Wang, Yaning Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drug development KW - FDA KW - Oncology KW - Integration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754269767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Integration+of+Pharmacometrics+in+Oncology+Drug+Development%3A+FDA+Perspective&rft.au=Wang%2C+Yaning&rft.aulast=Wang&rft.aufirst=Yaning&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Developing a Successful Career in Government T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754268159; 5815002 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Uhl, Kathleen Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754268159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Developing+a+Successful+Career+in+Government&rft.au=Uhl%2C+Kathleen&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Patient Demographics in Cardiovascular Drug Trials: Fda Reviews from 2007 to 2008 T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754263166; 5815277 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Umarjee, S AU - Lemtouni, S AU - Fadiran, E AU - Parekh, A Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Reviews KW - Demography KW - Drugs KW - FDA KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754263166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Patient+Demographics+in+Cardiovascular+Drug+Trials%3A+Fda+Reviews+from+2007+to+2008&rft.au=Umarjee%2C+S%3BLemtouni%2C+S%3BFadiran%2C+E%3BParekh%2C+A&rft.aulast=Umarjee&rft.aufirst=S&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Science of Sex Differences in the Pharmacokinetics and Pharmacodynamics of Drugs - Case Studies T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754261231; 5815334 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Fadiran, E AU - Parekh, A AU - Uhl, K Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Case studies KW - Drugs KW - Pharmacokinetics KW - Sex differences KW - Pharmacodynamics KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=The+Science+of+Sex+Differences+in+the+Pharmacokinetics+and+Pharmacodynamics+of+Drugs+-+Case+Studies&rft.au=Fadiran%2C+E%3BParekh%2C+A%3BUhl%2C+K&rft.aulast=Fadiran&rft.aufirst=E&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Mechanisms of Drug Action and Disposition to Predict Risk T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754260533; 5815048 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Abernethy, Darrell Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drugs KW - Disposition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754260533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Mechanisms+of+Drug+Action+and+Disposition+to+Predict+Risk&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Perspectives on Male Reproductive Safety during Drug Development T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754259684; 5815059 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - McNellis, Donald Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drug development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Regulatory+Perspectives+on+Male+Reproductive+Safety+during+Drug+Development&rft.au=McNellis%2C+Donald&rft.aulast=McNellis&rft.aufirst=Donald&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Perspective of Modeling and Simulation Approaches to DDI Prediction T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754259664; 5815014 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Huang, Shiew-Mei Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Simulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Regulatory+Perspective+of+Modeling+and+Simulation+Approaches+to+DDI+Prediction&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Patient-Centric Clinical Pharmacology: A Chrysalis?" T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754259386; 5814976 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Lesko, Lawrence Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Patient-Centric+Clinical+Pharmacology%3A+A+Chrysalis%3F%22&rft.au=Lesko%2C+Lawrence&rft.aulast=Lesko&rft.aufirst=Lawrence&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Linking Databases to Effectively Study Risk from Drug Exposure: The FDA Sentinel Initiative--a Progress Report T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754259009; 5815049 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Racoosin, Judith Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drugs KW - FDA KW - Databases KW - Progress reports KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Linking+Databases+to+Effectively+Study+Risk+from+Drug+Exposure%3A+The+FDA+Sentinel+Initiative--a+Progress+Report&rft.au=Racoosin%2C+Judith&rft.aulast=Racoosin&rft.aufirst=Judith&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - How to Double the Success Rate of Pediatric Trials? T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754258954; 5815046 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Gobburu, Joga Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=How+to+Double+the+Success+Rate+of+Pediatric+Trials%3F&rft.au=Gobburu%2C+Joga&rft.aulast=Gobburu&rft.aufirst=Joga&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Challenging Regulatory Aspects in the Development of Biologics Products T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754258922; 5815086 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Ghantous, Hanan Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Challenging+Regulatory+Aspects+in+the+Development+of+Biologics+Products&rft.au=Ghantous%2C+Hanan&rft.aulast=Ghantous&rft.aufirst=Hanan&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Utility of Integrating Prior Drug Disposition Data into a Physiologically-Based Pharmacokinetic (Pbpk) Model to Evaluate a Complex Drug-Drug Interaction: Cyp/Transporter Inhibition by Ketoconazole in Subjects with Renal Impairment (Ri) Taking Rivaroxaban T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754256992; 5815351 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Zhao, P AU - Grillo, J AU - Choi, Y AU - Booth, B AU - Rahman, N AU - Berglund, E AU - Zhang, L AU - Lesko, L AU - Huang, S Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Renal function KW - Drug interaction KW - Pharmacokinetics KW - Data processing KW - Ketoconazole KW - Disposition KW - Kidneys KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Utility+of+Integrating+Prior+Drug+Disposition+Data+into+a+Physiologically-Based+Pharmacokinetic+%28Pbpk%29+Model+to+Evaluate+a+Complex+Drug-Drug+Interaction%3A+Cyp%2FTransporter+Inhibition+by+Ketoconazole+in+Subjects+with+Renal+Impairment+%28Ri%29+Taking+Rivaroxaban&rft.au=Zhao%2C+P%3BGrillo%2C+J%3BChoi%2C+Y%3BBooth%2C+B%3BRahman%2C+N%3BBerglund%2C+E%3BZhang%2C+L%3BLesko%2C+L%3BHuang%2C+S&rft.aulast=Zhao&rft.aufirst=P&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Utility of Physiologically-Based Pharmacokinetic Modeling and Simulation in Drug Development and Challenges in Regulatory Reviews T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754256594; 5815269 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Zhao, P AU - Zhang, L AU - Lesko, L AU - Huang, S Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Reviews KW - Simulation KW - Drug development KW - Pharmacokinetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Utility+of+Physiologically-Based+Pharmacokinetic+Modeling+and+Simulation+in+Drug+Development+and+Challenges+in+Regulatory+Reviews&rft.au=Zhao%2C+P%3BZhang%2C+L%3BLesko%2C+L%3BHuang%2C+S&rft.aulast=Zhao&rft.aufirst=P&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - National and International Regulations and Their Effect on Pediatric Drug Development T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754256499; 5815044 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Burckart, Gilbert Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drug development KW - International regulations KW - Pediatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754256499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=National+and+International+Regulations+and+Their+Effect+on+Pediatric+Drug+Development&rft.au=Burckart%2C+Gilbert&rft.aulast=Burckart&rft.aufirst=Gilbert&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Bridging the Data Gap: From Discovery to Approval - HCV Drug Development Overview T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754253126; 5815030 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Struble, Kimberly Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - Drug development KW - Reviews KW - Data processing KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Bridging+the+Data+Gap%3A+From+Discovery+to+Approval+-+HCV+Drug+Development+Overview&rft.au=Struble%2C+Kimberly&rft.aulast=Struble&rft.aufirst=Kimberly&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Government Perspective T2 - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AN - 754253032; 5815005 JF - 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT 2010) AU - Burckart, Gil Y1 - 2010/05/17/ PY - 2010 DA - 2010 May 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.atitle=Government+Perspective&rft.au=Burckart%2C+Gil&rft.aulast=Burckart&rft.aufirst=Gil&rft.date=2010-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=111th+Annual+Meeting+of+the+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/annualmeeting2010/2010_Registration_Broc.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Defining Vulnerable Populations T2 - 8th UCLA Conference on Public Health and Disasters AN - 754261498; 5815604 JF - 8th UCLA Conference on Public Health and Disasters AU - Dodgen, Daniel Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Vulnerability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754261498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+UCLA+Conference+on+Public+Health+and+Disasters&rft.atitle=Defining+Vulnerable+Populations&rft.au=Dodgen%2C+Daniel&rft.aulast=Dodgen&rft.aufirst=Daniel&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+UCLA+Conference+on+Public+Health+and+Disasters&rft.issn=&rft_id=info:doi/ L2 - http://www.cphd.ucla.edu/conf2010program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Determination of Total trans Fat: An Infrared International Collaborative Validation Study T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754238569; 5789164 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Mossoba, M Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Determination+of+Total+trans+Fat%3A+An+Infrared+International+Collaborative+Validation+Study&rft.au=Mossoba%2C+M&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Optimization of trans Fat Determination by Infrared Spectroscopy T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754238519; 5789156 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Mossoba, M Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - I.R. spectroscopy KW - Infrared spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Optimization+of+trans+Fat+Determination+by+Infrared+Spectroscopy&rft.au=Mossoba%2C+M&rft.aulast=Mossoba&rft.aufirst=M&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Preparation, Isolation and Determination of Non-conjugated Geometric/positional Isomers of Linoleic Acid T2 - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AN - 754226656; 5788613 JF - 101st Annual Meeting and Expo of the American Oil Chemists' Society (AOCS 2010) AU - Fardin Kia, A AU - Delmonte, P AU - Rader, J Y1 - 2010/05/16/ PY - 2010 DA - 2010 May 16 KW - Linoleic acid KW - Isomers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754226656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.atitle=Preparation%2C+Isolation+and+Determination+of+Non-conjugated+Geometric%2Fpositional+Isomers+of+Linoleic+Acid&rft.au=Fardin+Kia%2C+A%3BDelmonte%2C+P%3BRader%2C+J&rft.aulast=Fardin+Kia&rft.aufirst=A&rft.date=2010-05-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+and+Expo+of+the+American+Oil+Chemists%27+Society+%28AOCS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://annualmeeting.aocs.org/content/AOCS_AM10_Program_FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - New Findings from Integrating Administrative and Financial Databases to Estimate Price of Hospitalizations T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754251212; 5791819 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Wong, H AU - Levit, K AU - Sun, Y Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754251212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=New+Findings+from+Integrating+Administrative+and+Financial+Databases+to+Estimate+Price+of+Hospitalizations&rft.au=Wong%2C+H%3BLevit%2C+K%3BSun%2C+Y&rft.aulast=Wong&rft.aufirst=H&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - ISPOR Good Research Practices for Establishing and Reporting Evidence of the Content Validity of New PRO Instruments T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754248791; 5791787 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Burke, Laurie AU - Martin, Mona AU - Gwaltney, Chad Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754248791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=ISPOR+Good+Research+Practices+for+Establishing+and+Reporting+Evidence+of+the+Content+Validity+of+New+PRO+Instruments&rft.au=Burke%2C+Laurie%3BMartin%2C+Mona%3BGwaltney%2C+Chad&rft.aulast=Burke&rft.aufirst=Laurie&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Engaging Stakeholders to Enhance Performance of Comparative Effectiveness Research T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754241853; 5791843 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Slutsky, Jean AU - Mcelwee, Newell AU - Wall, Eric AU - Bright, Jennifer Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - Stakeholders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=Engaging+Stakeholders+to+Enhance+Performance+of+Comparative+Effectiveness+Research&rft.au=Slutsky%2C+Jean%3BMcelwee%2C+Newell%3BWall%2C+Eric%3BBright%2C+Jennifer&rft.aulast=Slutsky&rft.aufirst=Jean&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory Evaluation of Patient-Reported Outcome Measures (Pros) Used in Clinical Trials T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754233606; 5791778 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Burke, Laurie AU - Cai, June AU - Trentacosti, Ann AU - Patrick, Donald Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=Regulatory+Evaluation+of+Patient-Reported+Outcome+Measures+%28Pros%29+Used+in+Clinical+Trials&rft.au=Burke%2C+Laurie%3BCai%2C+June%3BTrentacosti%2C+Ann%3BPatrick%2C+Donald&rft.aulast=Burke&rft.aufirst=Laurie&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Patient-Reported Outcomes for Adverse Event Monitoring T2 - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AN - 754233446; 5791753 JF - 15th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR 2010) AU - Burke, Laurie AU - Reeve, Bryce AU - Coons, Stephen Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 KW - Side effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.atitle=Patient-Reported+Outcomes+for+Adverse+Event+Monitoring&rft.au=Burke%2C+Laurie%3BReeve%2C+Bryce%3BCoons%2C+Stephen&rft.aulast=Burke&rft.aufirst=Laurie&rft.date=2010-05-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Meeting+of+the+International+Society+for+Pharmacoeconomics+and+Outcomes+Research+%28ISPOR+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ispor.org/meetings/atlanta0510/documents/mini-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Salivary gland and nasopharyngeal cancers in individuals with acquired immunodeficiency syndrome in United States AN - 745719087; 13163585 AB - Individuals with acquired immunodeficiency syndrome (AIDS) manifest an increased risk of cancer, particularly cancers caused by oncogenic viruses. Because some salivary gland and nasopharyngeal cancers are associated with Epstein Barr virus, the impact of AIDS on these cancers needs further evaluation. We used linked U.S. AIDS and cancer registry data (N = 519,934 people with AIDS) to derive standardized incidence ratios (SIRs) comparing risk of salivary gland and nasopharyngeal cancers to the general population. For salivary gland cancers (N = 43 cases), individuals with AIDS had strongly elevated risks for lymphoepithelial carcinoma (SIR 39, 95% CI 16-81) and squamous cell carcinoma (SIR 4.9, 95% CI 2.5-8.6). Among nasopharyngeal cancers (N = 39 cases), risks were elevated for both keratinizing and nonkeratinizing carcinomas (SIR 2.4, 95% CI 1.5-3.7 and SIR 2.4, 95% CI 1.2-4.4, respectively). The elevated risks of salivary gland and nasopharyngeal cancers among people with AIDS suggest that immunosuppression and oncogenic viral infections are etiologically important. JF - International Journal of Cancer AU - Shebl, Fatma M AU - Bhatia, Kishor AU - Engels, Eric A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, sheblf@mail.nih.gov Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 2503 EP - 2508 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 126 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Acquired immune deficiency syndrome KW - Data processing KW - Viruses KW - Immunodeficiency KW - squamous cell carcinoma KW - Salivary gland KW - Infection KW - Cancer KW - USA KW - Epstein-Barr virus KW - infection KW - Standards KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745719087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Salivary+gland+and+nasopharyngeal+cancers+in+individuals+with+acquired+immunodeficiency+syndrome+in+United+States&rft.au=Shebl%2C+Fatma+M%3BBhatia%2C+Kishor%3BEngels%2C+Eric+A&rft.aulast=Shebl&rft.aufirst=Fatma&rft.date=2010-05-15&rft.volume=126&rft.issue=10&rft.spage=2503&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.24930 L2 - http://www3.interscience.wiley.com/journal/122615552/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Immunodeficiency; squamous cell carcinoma; Infection; Salivary gland; Immunosuppression; Viruses; infection; Standards; Cancer; Epstein-Barr virus; USA DO - http://dx.doi.org/10.1002/ijc.24930 ER - TY - JOUR T1 - Association between blood lead and the risk of amyotrophic lateral sclerosis. AN - 733087697; 20406759 AB - The authors conducted a 2003-2007 case-control study including 184 cases and 194 controls to examine the association between blood lead and the risk of amyotrophic lateral sclerosis (ALS) among US veterans and to explore the influence on this association of bone turnover and genetic factors related to lead toxicokinetics. Blood lead, plasma biomarkers of bone formation (procollagen type 1 amino-terminal peptide (PINP)) and resorption (C-terminal telopeptides of type 1 collagen (CTX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measured. Odds ratios and 95% confidence intervals for the association of blood lead with ALS were estimated with unconditional logistic regression after adjustment for age and bone turnover. Blood lead levels were higher among cases compared with controls (P < 0.0001, age adjusted). A doubling of blood lead was associated with a 1.9-fold increased risk of ALS (95% confidence interval: 1.3, 2.7) after adjustment for age and CTX. Additional adjustment for PINP did not alter the results. Significant lead-ALS associations were observed in substrata of PINP and CTX levels. The K59N polymorphism in the ALAD gene did not modify the lead-ALS association (P = 0.32). These results extend earlier findings by accounting for bone turnover in confirming the association between elevated blood lead level and higher risk of ALS. JF - American journal of epidemiology AU - Fang, Fang AU - Kwee, Lydia C AU - Allen, Kelli D AU - Umbach, David M AU - Ye, Weimin AU - Watson, Mary AU - Keller, Jean AU - Oddone, Eugene Z AU - Sandler, Dale P AU - Schmidt, Silke AU - Kamel, Freya AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2010/05/15/ PY - 2010 DA - 2010 May 15 SP - 1126 EP - 1133 VL - 171 IS - 10 KW - Biomarkers KW - 0 KW - Lead KW - 2P299V784P KW - Porphobilinogen Synthase KW - EC 4.2.1.24 KW - Index Medicus KW - Odds Ratio KW - Lead Poisoning -- blood KW - Humans KW - Aged KW - Porphobilinogen Synthase -- genetics KW - Bone and Bones -- metabolism KW - Bone Resorption -- complications KW - Bone Resorption -- epidemiology KW - Registries KW - Logistic Models KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Lead Poisoning -- complications KW - Case-Control Studies KW - Confidence Intervals KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Osteogenesis KW - Amyotrophic Lateral Sclerosis -- genetics KW - Veterans -- statistics & numerical data KW - Amyotrophic Lateral Sclerosis -- epidemiology KW - Amyotrophic Lateral Sclerosis -- blood KW - Environmental Exposure -- adverse effects KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733087697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Association+between+blood+lead+and+the+risk+of+amyotrophic+lateral+sclerosis.&rft.au=Fang%2C+Fang%3BKwee%2C+Lydia+C%3BAllen%2C+Kelli+D%3BUmbach%2C+David+M%3BYe%2C+Weimin%3BWatson%2C+Mary%3BKeller%2C+Jean%3BOddone%2C+Eugene+Z%3BSandler%2C+Dale+P%3BSchmidt%2C+Silke%3BKamel%2C+Freya&rft.aulast=Fang&rft.aufirst=Fang&rft.date=2010-05-15&rft.volume=171&rft.issue=10&rft.spage=1126&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=1476-6256&rft_id=info:doi/10.1093%2Faje%2Fkwq063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-27 N1 - Date created - 2010-05-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 1998 Dec 28;102-103:363-7 [10022280] Am J Epidemiol. 1997 Jun 15;145(12):1076-88 [9199537] Toxicology. 1999 Jul 15;135(2-3):77-85 [10463764] Neurology. 2005 Jan 11;64(1):32-7 [15642900] Neuroepidemiology. 2005;24(3):141-50 [15650320] Neurodegener Dis. 2005;2(3-4):195-201 [16909025] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1742-5 [16985039] Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2072-6 [17932355] Mil Med. 2008 Feb;173(2):182-6 [18333495] Neuroepidemiology. 2008;30(3):180-90 [18421218] Neuroepidemiology. 2008;30(3):191-204 [18421219] Ann Neurol. 2009 Jan;65 Suppl 1:S3-9 [19191304] Am J Epidemiol. 2000 Jan 15;151(2):156-63 [10645818] Environ Health Perspect. 2000 Mar;108 Suppl 1:23-8 [10698721] Am J Epidemiol. 2001 Jul 1;154(1):1-13 [11427399] Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9 [11464847] Environ Health Perspect. 2001 Aug;109(8):827-32 [11564619] Epidemiology. 2002 May;13(3):311-9 [11964933] Environ Health Perspect. 2003 Aug;111(10):1335-9 [12896855] Neurology. 2003 Sep 23;61(6):742-9 [14504315] Neurology. 2003 Sep 23;61(6):750-6 [14504316] Am J Epidemiol. 2004 Jul 1;160(1):26-33 [15229114] J Neurol Neurosurg Psychiatry. 1970 Dec;33(6):877-85 [5497881] Neurology. 1976 Feb;26(2):167-72 [946326] Ann Clin Res. 1981 Apr;13(2):102-7 [7235610] Am J Epidemiol. 1986 May;123(5):790-9 [3962963] Neuroepidemiology. 1986;5(1):29-38 [3748267] Toxicology. 1988 Apr;49(1):35-41 [3376124] Neurology. 1991 Jul;41(7):1077-84 [2067636] Br J Ind Med. 1992 Nov;49(11):791-8 [1463680] J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1200-6 [8229031] Am J Epidemiol. 1996 Oct 15;144(8):749-59 [8857824] Neuroepidemiology. 1999;18(4):194-202 [10364720] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/aje/kwq063 ER - TY - JOUR T1 - A Study of First Moments in Underground Mine Emergency Response AN - 744700157; 13055995 AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) conducted seven focus groups and 10 individual interviews to gather data on what happens in the first crucial moments of a mine emergency. The goal of the project was to learn about responses on-site during the initial phases of a mine emergency to further improve response. The subjects represented underground coal and salt mines in the southern, western, mid-western, and eastern parts of the United States. They included on-site responders, mine rescue team members, and experts in mine emergency response with extensive experience in managing mine disasters. The types of disasters the subjects experienced were diverse, including explosions, fires, and inundations (sudden floods of water or inrushes of dangerous gases). This study was unique in its focus on the first moments in an emergency response, in studying underground coal mine emergencies and in utilizing a focus group methodology. Results indicated that there were common themes in initial response, which included the importance of mine emergency planning and training, quantity and quality of communication providing information for decision-making, leadership and trust, plus individual personal issues. Previous relevant studies are presented and the researchers discuss the data providing specific examples. The article concludes with recommendations to enhance initial response in the first critical moments of an emergency. JF - Journal of Homeland Security and Emergency Management AU - Kowalski-Trakofler, Kathleen AU - Vaught, Charles AU - Brnich, Jr Michael AU - Jansky, Jacqueline AD - National Institute for Occupational Safety and Health Y1 - 2010/05/14/ PY - 2010 DA - 2010 May 14 SP - 1652 PB - Berkeley Electronic Press, 805 Camelia Street Berkeley CA 94710 USA VL - 7 IS - 1 SN - 1547-7355, 1547-7355 KW - Health & Safety Science Abstracts KW - homeland security KW - Occupational safety KW - Coal KW - Floods KW - Fires KW - Training KW - Disasters KW - Mines KW - Explosions KW - Salts KW - USA KW - Gases KW - Communications KW - Emergency preparedness KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744700157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Homeland+Security+and+Emergency+Management&rft.atitle=A+Study+of+First+Moments+in+Underground+Mine+Emergency+Response&rft.au=Kowalski-Trakofler%2C+Kathleen%3BVaught%2C+Charles%3BBrnich%2C+Jr+Michael%3BJansky%2C+Jacqueline&rft.aulast=Kowalski-Trakofler&rft.aufirst=Kathleen&rft.date=2010-05-14&rft.volume=7&rft.issue=1&rft.spage=1652&rft.isbn=&rft.btitle=&rft.title=Journal+of+Homeland+Security+and+Emergency+Management&rft.issn=15477355&rft_id=info:doi/ L2 - http://www.bepress.com/jhsem/vol7/iss1/39 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Fires; homeland security; Training; Occupational safety; Disasters; Coal; Mines; Explosions; Salts; Communications; Gases; Floods; Emergency preparedness; USA ER - TY - CPAPER T1 - The FDA Approval Process for Cardiac Drugs and Devices T2 - 31st Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2010) AN - 839698509; 5936150 JF - 31st Annual Scientific Sessions of the Heart Rhythm Society (Heart Rhythm 2010) AU - MacFarland, William Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 KW - {Q1} KW - Drugs KW - FDA KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839698509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=31st+Annual+Scientific+Sessions+of+the+Heart+Rhythm+Society+%28Heart+Rhythm+2010%29&rft.atitle=The+FDA+Approval+Process+for+Cardiac+Drugs+and+Devices&rft.au=MacFarland%2C+William&rft.aulast=MacFarland&rft.aufirst=William&rft.date=2010-05-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={11A396D9-0C49-480 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-11 N1 - Last updated - 2011-01-14 ER - TY - CONF T1 - Challenges and opportunities in establishing scientific and regulatory standards for assuring therapeutic equivalence of modified-release products: workshop summary report. AN - 733912427; 20347972 AB - Modified-release products are complex dosage forms designed to release drug in a controlled manner to achieve desired efficacy and safety. Inappropriate control of drug release from such products may result in reduced efficacy or increased toxicity. This workshop provided an opportunity for pharmaceutical scientists from academia, industry and regulatory agencies to discuss current regulatory expectations and industry practices for demonstrating pharmaceutical equivalence and bioequivalence of MR products, further facilitating the establishment of regulatory standards for ensuring therapeutic equivalence of these products. JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences AU - Chen, Mei-Ling AU - Shah, Vinod P AU - Ganes, Derek AU - Midha, Kamal K AU - Caro, James AU - Nambiar, Prabu AU - Rocci, Mario L AU - Thombre, Avinash G AU - Abrahamsson, Bertil AU - Conner, Dale AU - Davit, Barbara AU - Fackler, Paul AU - Farrell, Colm AU - Gupta, Suneel AU - Katz, Russell AU - Mehta, Mehul AU - Preskorn, Sheldon H AU - Sanderink, Gerard AU - Stavchansky, Salomon AU - Temple, Robert AU - Wang, Yaning AU - Winkle, Helen AU - Yu, Lawrence Y1 - 2010/05/12/ PY - 2010 DA - 2010 May 12 SP - 148 EP - 153 VL - 40 IS - 2 KW - Delayed-Action Preparations KW - 0 KW - Pyridines KW - Bupropion KW - 01ZG3TPX31 KW - Methylphenidate KW - 207ZZ9QZ49 KW - zolpidem KW - 7K383OQI23 KW - Index Medicus KW - United States KW - Therapeutic Equivalency KW - United States Food and Drug Administration KW - Methylphenidate -- pharmacology KW - Chemistry, Pharmaceutical KW - Pyridines -- pharmacokinetics KW - Drug Approval KW - Methylphenidate -- pharmacokinetics KW - Pyridines -- pharmacology KW - Bupropion -- pharmacokinetics KW - Bupropion -- pharmacology KW - Delayed-Action Preparations -- pharmacology KW - Delayed-Action Preparations -- pharmacokinetics KW - Drug and Narcotic Control -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733912427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=European+journal+of+pharmaceutical+sciences+%3A+official+journal+of+the+European+Federation+for+Pharmaceutical+Sciences&rft.atitle=Challenges+and+opportunities+in+establishing+scientific+and+regulatory+standards+for+assuring+therapeutic+equivalence+of+modified-release+products%3A+workshop+summary+report.&rft.au=Chen%2C+Mei-Ling%3BShah%2C+Vinod+P%3BGanes%2C+Derek%3BMidha%2C+Kamal+K%3BCaro%2C+James%3BNambiar%2C+Prabu%3BRocci%2C+Mario+L%3BThombre%2C+Avinash+G%3BAbrahamsson%2C+Bertil%3BConner%2C+Dale%3BDavit%2C+Barbara%3BFackler%2C+Paul%3BFarrell%2C+Colm%3BGupta%2C+Suneel%3BKatz%2C+Russell%3BMehta%2C+Mehul%3BPreskorn%2C+Sheldon+H%3BSanderink%2C+Gerard%3BStavchansky%2C+Salomon%3BTemple%2C+Robert%3BWang%2C+Yaning%3BWinkle%2C+Helen%3BYu%2C+Lawrence&rft.aulast=Chen&rft.aufirst=Mei-Ling&rft.date=2010-05-12&rft.volume=40&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmaceutical+sciences+%3A+official+journal+of+the+European+Federation+for+Pharmaceutical+Sciences&rft.issn=1879-0720&rft_id=info:doi/10.1016%2Fj.ejps.2010.03.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-18 N1 - Date created - 2010-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ejps.2010.03.017 ER - TY - CPAPER T1 - Drugs Associated with Hemorrhagic Pancreatitis in the Food and Drug Administration Adverse Event Database and Mitochondrial Toxicity T2 - XXX International Congress of the European Association of Poisons Centres and Clinical Toxicologists AN - 754233450; 5783115 JF - XXX International Congress of the European Association of Poisons Centres and Clinical Toxicologists AU - Burkhart, K AU - Szarfman, A AU - Lyndly, J Y1 - 2010/05/11/ PY - 2010 DA - 2010 May 11 KW - Toxicity KW - Drugs KW - Side effects KW - Mitochondria KW - Databases KW - Pancreatitis KW - Hemorrhage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754233450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXX+International+Congress+of+the+European+Association+of+Poisons+Centres+and+Clinical+Toxicologists&rft.atitle=Drugs+Associated+with+Hemorrhagic+Pancreatitis+in+the+Food+and+Drug+Administration+Adverse+Event+Database+and+Mitochondrial+Toxicity&rft.au=Burkhart%2C+K%3BSzarfman%2C+A%3BLyndly%2C+J&rft.aulast=Burkhart&rft.aufirst=K&rft.date=2010-05-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXX+International+Congress+of+the+European+Association+of+Poisons+Centres+and+Clinical+Toxicologists&rft.issn=&rft_id=info:doi/ L2 - http://www.eapcct.org/publicfile.php?folder=congress&file=Programme_20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Modeling of the Magnetic Field around a Ferrite-Cored Generator in a Proximity Detection System T2 - 14th Biennial IEEE Conference on Electromagnetic Field Computation (CEFC 2010) AN - 754223072; 5781113 JF - 14th Biennial IEEE Conference on Electromagnetic Field Computation (CEFC 2010) AU - Li, Jingcheng AU - Carr, Jacob AU - Bartels, John Y1 - 2010/05/09/ PY - 2010 DA - 2010 May 09 KW - Magnetic fields KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754223072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Biennial+IEEE+Conference+on+Electromagnetic+Field+Computation+%28CEFC+2010%29&rft.atitle=Modeling+of+the+Magnetic+Field+around+a+Ferrite-Cored+Generator+in+a+Proximity+Detection+System&rft.au=Li%2C+Jingcheng%3BCarr%2C+Jacob%3BBartels%2C+John&rft.aulast=Li&rft.aufirst=Jingcheng&rft.date=2010-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Biennial+IEEE+Conference+on+Electromagnetic+Field+Computation+%28CEFC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cefc2010.org/CEFC_2010_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A discrete event model to track Listeria monocytogenes in the retail environment T2 - 17th International Symposium On Problems Of Listeriosis (ISOPOL XVII) AN - 754180521; 5724896 JF - 17th International Symposium On Problems Of Listeriosis (ISOPOL XVII) AU - Pouillot, Regis AU - Gallagher, Daniel Y1 - 2010/05/05/ PY - 2010 DA - 2010 May 05 KW - Models KW - Listeria monocytogenes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754180521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+International+Symposium+On+Problems+Of+Listeriosis+%28ISOPOL+XVII%29&rft.atitle=A+discrete+event+model+to+track+Listeria+monocytogenes+in+the+retail+environment&rft.au=Pouillot%2C+Regis%3BGallagher%2C+Daniel&rft.aulast=Pouillot&rft.aufirst=Regis&rft.date=2010-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+International+Symposium+On+Problems+Of+Listeriosis+%28ISOPOL+XVII%29&rft.issn=&rft_id=info:doi/ L2 - http://isopol.esb.ucp.pt/docs/isopol_programa.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - RPRT T1 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. [Part 1 of 1] T2 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. AN - 756827198; 14319-100168_0001 AB - PURPOSE: The transport of any laboratory personnel suspected of having potential occupational exposure to infectious agents under study at the National Interagency Biodefense Campus (NIBC), located at Fort Detrick, Maryland, to the Special Clinical Studies Unit at the National Institutes of Health (NIH) Bethesda, Maryland Campus is proposed. The NIH Bethesda campus is inside the Capital Beltway (Interstate 495) along the northern boundary of the Bethesda Central Business District in Montgomery County. Fort Detrick is a U.S. Army Medical Command Installation located on 1,200 acres in Frederick. The National Institute of Allergy and Infectious Disease (NIAID), a component of the NIH, will occupy an integrated research facility (IRF) currently being built at Fort Detrick as part of the NIBC. The IRF will contain specially designed laboratories and animal research facilities for conducting biodefense and emerging infectious disease research. Key issues identified during scoping include those related to community safety, security during transport, accident risk, and coordination of accident response. Alternatives analyzed in this final EIS include a No Action Alternative and the proposed action. Under the proposed action, which is also the preferred alternative, laboratory personnel potentially exposed to infectious agents under study at the NIBC would be transported to the NIH Special Clinical Studies Unit in Bethesda for monitoring, observation and treatment. Transport would use a government-owned vehicle and could entail escort by one or more, regular police patrol vehicles over interstate and local roads. The most direct transportation route by motor vehicle would include Interstate 270 and Interstate 495. Prior to departing Fort Detrick, ambulance and law enforcement personnel would determine the appropriate route based upon roadway conditions, traffic volume, and other factors. Local police would coordinate resources, initiate notification procedures, and determine escort requirements. In the event of a motor vehicle accident involving the ambulance, first responders from local emergency service organizations would utilize existing procedures, protocols, and protective equipment to manage the incident. Special features of the NIH transport vehicle would make dispersion of infectious agents from the potentially infected laboratory personnel highly unlikely. POSITIVE IMPACTS: The proposed action would allow NIAID to achieve its research goals while ensuring that NIAID employees conducting research at the new IRF at Fort Detrick would receive appropriate medical evaluation and treatment in the event of any potential occupational exposure to infectious agents. NEGATIVE IMPACTS: Implementation of the proposed action involves risks inherent to the delivery of emergency services, including the operation of vehicles and the potential for exposure to pathogens. However, many of these risks are mitigated by the adoption of policies and procedures that are reinforced through training and oversight. PRIOR REFERENCES: For the abstract of the draft EIS, see 09-0135D, Volume 33, Number 2. JF - EPA number: 100168, 311 pages, May 4, 2010 PY - 2010 VL - 1 KW - Hazardous Substances KW - Health Hazards KW - Highways KW - Military Facilities (Army) KW - Motor Vehicles KW - Research KW - Research Facilities KW - Roads KW - Safety KW - Transportation KW - Fort Detrick KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/756827198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Full+Text&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.title=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2010-06-29 N1 - SuppNotes - Final. Preparation date: May 4, 2010 N1 - Last updated - 2011-12-16 ER - TY - CPAPER T1 - FD Evaluation of Biomarkers T2 - Sixth Annual Biomarker World Congress AN - 754215644; 5768770 JF - Sixth Annual Biomarker World Congress AU - Roscoe, Donna Y1 - 2010/05/04/ PY - 2010 DA - 2010 May 04 KW - Bioindicators KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754215644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Biomarker+World+Congress&rft.atitle=FD+Evaluation+of+Biomarkers&rft.au=Roscoe%2C+Donna&rft.aulast=Roscoe&rft.aufirst=Donna&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Biomarker+World+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.biomarkerworldcongress.com/bmc_content.aspx?id=96849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Role of Biomarkers in Drug Development: Application in Late Phase Clinical Trials T2 - Sixth Annual Biomarker World Congress AN - 754212053; 5768751 JF - Sixth Annual Biomarker World Congress AU - Wang, Yaning Y1 - 2010/05/04/ PY - 2010 DA - 2010 May 04 KW - Clinical trials KW - Bioindicators KW - Drug development KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754212053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Biomarker+World+Congress&rft.atitle=Role+of+Biomarkers+in+Drug+Development%3A+Application+in+Late+Phase+Clinical+Trials&rft.au=Wang%2C+Yaning&rft.aulast=Wang&rft.aufirst=Yaning&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Biomarker+World+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.biomarkerworldcongress.com/bmc_content.aspx?id=96849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Biomarkers and the Development of Personalized Medicine: A Regulatory Perspective T2 - Sixth Annual Biomarker World Congress AN - 754208826; 5768734 JF - Sixth Annual Biomarker World Congress AU - Kalush, Francis Y1 - 2010/05/04/ PY - 2010 DA - 2010 May 04 KW - Bioindicators KW - Biomarkers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754208826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Biomarker+World+Congress&rft.atitle=Biomarkers+and+the+Development+of+Personalized+Medicine%3A+A+Regulatory+Perspective&rft.au=Kalush%2C+Francis&rft.aulast=Kalush&rft.aufirst=Francis&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Biomarker+World+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.biomarkerworldcongress.com/bmc_content.aspx?id=96849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - RPRT T1 - TRANSPORT OF LABORATORY PERSONNEL POTENTIALLY EXPOSED TO INFECTIOUS AGENTS FROM FORT DETRICK, FREDERICK, MARYLAND TO THE NATIONAL INSTITUTES OF HEALTH CLINICAL CENTER, BETHESDA, MARYLAND. AN - 16373143; 14319 AB - PURPOSE: The transport of any laboratory personnel suspected of having potential occupational exposure to infectious agents under study at the National Interagency Biodefense Campus (NIBC), located at Fort Detrick, Maryland, to the Special Clinical Studies Unit at the National Institutes of Health (NIH) Bethesda, Maryland Campus is proposed. The NIH Bethesda campus is inside the Capital Beltway (Interstate 495) along the northern boundary of the Bethesda Central Business District in Montgomery County. Fort Detrick is a U.S. Army Medical Command Installation located on 1,200 acres in Frederick. The National Institute of Allergy and Infectious Disease (NIAID), a component of the NIH, will occupy an integrated research facility (IRF) currently being built at Fort Detrick as part of the NIBC. The IRF will contain specially designed laboratories and animal research facilities for conducting biodefense and emerging infectious disease research. Key issues identified during scoping include those related to community safety, security during transport, accident risk, and coordination of accident response. Alternatives analyzed in this final EIS include a No Action Alternative and the proposed action. Under the proposed action, which is also the preferred alternative, laboratory personnel potentially exposed to infectious agents under study at the NIBC would be transported to the NIH Special Clinical Studies Unit in Bethesda for monitoring, observation and treatment. Transport would use a government-owned vehicle and could entail escort by one or more, regular police patrol vehicles over interstate and local roads. The most direct transportation route by motor vehicle would include Interstate 270 and Interstate 495. Prior to departing Fort Detrick, ambulance and law enforcement personnel would determine the appropriate route based upon roadway conditions, traffic volume, and other factors. Local police would coordinate resources, initiate notification procedures, and determine escort requirements. In the event of a motor vehicle accident involving the ambulance, first responders from local emergency service organizations would utilize existing procedures, protocols, and protective equipment to manage the incident. Special features of the NIH transport vehicle would make dispersion of infectious agents from the potentially infected laboratory personnel highly unlikely. POSITIVE IMPACTS: The proposed action would allow NIAID to achieve its research goals while ensuring that NIAID employees conducting research at the new IRF at Fort Detrick would receive appropriate medical evaluation and treatment in the event of any potential occupational exposure to infectious agents. NEGATIVE IMPACTS: Implementation of the proposed action involves risks inherent to the delivery of emergency services, including the operation of vehicles and the potential for exposure to pathogens. However, many of these risks are mitigated by the adoption of policies and procedures that are reinforced through training and oversight. PRIOR REFERENCES: For the abstract of the draft EIS, see 09-0135D, Volume 33, Number 2. JF - EPA number: 100168, 311 pages, May 4, 2010 PY - 2010 KW - Hazardous Substances KW - Health Hazards KW - Highways KW - Military Facilities (Army) KW - Motor Vehicles KW - Research KW - Research Facilities KW - Roads KW - Safety KW - Transportation KW - Fort Detrick KW - Maryland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16373143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2010-05-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.title=TRANSPORT+OF+LABORATORY+PERSONNEL+POTENTIALLY+EXPOSED+TO+INFECTIOUS+AGENTS+FROM+FORT+DETRICK%2C+FREDERICK%2C+MARYLAND+TO+THE+NATIONAL+INSTITUTES+OF+HEALTH+CLINICAL+CENTER%2C+BETHESDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2010-06-29 N1 - SuppNotes - Final. Preparation date: May 4, 2010 N1 - Last updated - 2011-12-16 ER - TY - JOUR T1 - Goitrogenic Anions, Thyroid-Stimulating Hormone, and Thyroid Hormone in Infants AN - 831153071; 13820677 AB - Environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. U.S. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (TSH) and lower thyroxine (T4). There are no studies with individual measures of thyroid function and these goitrogens available in infants. We examined the association of urinary perchlorate, nitrate, iodide, and thiocyanate with urinary T4 and TSH in infants and whether that association differed by sex or iodide status. We used data and samples from the Study of Estrogen Activity and Development, which assessed hormone levels of full-term infants over the first 12 months of life. The study included 92 full-term infants between birth and 1 year of age seen up to four times. Perchlorate, thiocyanate, nitrate, and iodide were measured in 206 urine samples; TSH and T4 and were measured in urines and in 50 blood samples. In separate mixed models, adjusting for creatinine, age, sex, and body mass index, infants with higher urinary perchlorate, nitrate or thiocyanate had higher urinary TSH. With all three modeled, children with higher nitrate and thiocyanate had higher TSH, but higher perchlorate was associated with TSH only in children with low iodide. Unexpectedly, exposure to the three chemicals was generally associated with higher T4. The association of perchlorate exposure with increased urinary TSH in infants with low urinary iodide is consistent with previous findings. Higher thiocyanate and nitrate exposure were also associated with higher TSH in infants. JF - Environmental Health Perspectives AU - Cao, Yang AU - Blount, Benjamin C AU - Valentin-Blasini, Liza AU - Bernbaum, Judy C AU - Phillips, Terry M AU - Rogan, Walter J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/05/03/ PY - 2010 DA - 2010 May 03 SP - 1332 EP - 1337 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 9 SN - 0091-6765, 0091-6765 KW - Environment Abstracts KW - infant KW - iodide KW - nitrate KW - perchlorate KW - thiocyanate KW - thyrotropin KW - thyroxine KW - USA KW - Age KW - Nitrates KW - Urine KW - iodides KW - Thyroid KW - Children KW - Hormones KW - Infants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/831153071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Goitrogenic+Anions%2C+Thyroid-Stimulating+Hormone%2C+and+Thyroid+Hormone+in+Infants&rft.au=Cao%2C+Yang%3BBlount%2C+Benjamin+C%3BValentin-Blasini%2C+Liza%3BBernbaum%2C+Judy+C%3BPhillips%2C+Terry+M%3BRogan%2C+Walter+J&rft.aulast=Cao&rft.aufirst=Yang&rft.date=2010-05-03&rft.volume=118&rft.issue=9&rft.spage=1332&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Age; Nitrates; iodides; Urine; Thyroid; Children; Hormones; perchlorate; Infants; USA DO - http://dx.doi.org/10.1289/ehp.0901736 ER - TY - JOUR T1 - Examining long-term effects of Cuídate - a sexual risk reduction program in Mexican youth AN - 892944567; 4231469 AB - OBJECTIVE: To examine the effectiveness of a safer sex program (Cuídate) on sexual behavior, use of condoms, and use of other contraceptives among Mexican youth 48 months after the intervention. METHODS: A total of 708 or 85% of those who participated in the original randomized control study (n = 829) were assessed in the 48-month follow-up. Each participant completed a questionnaire on sexual behavior. RESULTS: Findings indicated that adolescents who participated in the Cuídate program were more likely to be older at first sex (odds ratio [OR], 1.27; 95% confidence interval [CI], 0.41-2.12; P < 0.05) and to use condoms at first sex (OR, 1.75; 95% CI, 1.14-2.69; P < 0.05) or some other type of contraception at first sex (OR, 1.53; 95% CI, 1.00-2.33; P < 0.05) than those in the control group. Effects of the intervention on consistent condom use, condom use at last sex, and number of sexual partners were not significant. Gender did not moderate any intervention effects. Social desirability moderated the effect of the intervention on age at first sex. CONCLUSIONS: Results demonstrate the efficacy of Cuídate among Mexican adolescents. Future research, policy, and practice efforts should be directed at sustaining safe sex practices across adolescents' developmental and relationship trajectory. // ABSTRACT IN SPANISH: OBJETIVOS: Examinar la eficacia de un programa de promoción de actividad sexual de menor riesgo (Cuídate) en cuanto al comportamiento sexual, el uso de condones y el uso de otros anticonceptivos en jóvenes mexicanos, 48 meses después de la intervención. MÉTODOS: En el seguimiento después de 48 meses, se evaluó un total de 708 (85%) de los que participaron en el estudio de control aleatorizado original (n = 829). Cada participante respondió a un cuestionario sobre su comportamiento sexual. RESULTADOS: Los resultados indicaron que los adolescentes que participaron en el programa "Cuídate" tenían una probabilidad más alta de tener una edad mayor en la primera relación sexual (razón de posibilidades [OR]: 1,27; intervalo de confianza [IC]: de 95%, 0,412,12; p < 0,05) y de usar condones (OR: 1,75; IC 95%: 1,142,69; P < 0,05) o algún otro tipo de medida anticonceptiva en la primera relación sexual (OR: 1,53; IC 95%: 1,002,33; P < 0,05) en comparación con los del grupo de referencia. Los efectos de la intervención sobre el uso constante de condones, el uso de condones en la última relación sexual y el número de compañeros sexuales no fueron considerables. El género no moderó los efectos de la intervención. La conveniencia social moderó el efecto de la intervención sobre la edad en la primera relación sexual. CONCLUSIONES: Los resultados demuestran la eficacia del programa "Cuídate" en los adolescentes mexicanos. En el futuro, la investigación, las políticas y la práctica deberán diri-girse a promover actividades sexuales de menor riesgo en el desarrollo y las relaciones de los adolescentes. JF - Pan American journal of public health AU - Villarruel, Antonia M AU - Zhou, Yan AU - Gallegos, Esther C AU - Ronis, David L AD - University of Michigan, Ann Arbor ; US Food and Drug Administration ; Universidad Autónoma de Nuevo León Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 345 EP - 351 VL - 27 IS - 5 SN - 1020-4989, 1020-4989 KW - Anthropology KW - Risk KW - Mexico KW - Questionnaires KW - Sexual behaviour KW - Contraceptive methods KW - Health policy KW - Sexual health KW - Adolescents KW - Youth KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/892944567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pan+American+journal+of+public+health&rft.atitle=Examining+long-term+effects+of+Cu%C3%ADdate+-+a+sexual+risk+reduction+program+in+Mexican+youth&rft.au=Villarruel%2C+Antonia+M%3BZhou%2C+Yan%3BGallegos%2C+Esther+C%3BRonis%2C+David+L&rft.aulast=Villarruel&rft.aufirst=Antonia&rft.date=2010-05-01&rft.volume=27&rft.issue=5&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Pan+American+journal+of+public+health&rft.issn=10204989&rft_id=info:doi/10.1590%2FS1020-49892010000500004 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Open access N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11563 1025 1542 11325 6071; 13779 652 5676 646 6091; 10449 5772; 593; 11565 5772 11538; 10541; 2838 2836 1636 1635 11574; 5788 11888 10472; 11035; 251 293 14 DO - http://dx.doi.org/10.1590/S1020-49892010000500004 ER - TY - JOUR T1 - Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins AN - 877574646; 13024811 AB - Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs with ultrahigh molecular weights: tense (T) state PolyHb (M W =16.59MDa and P 50 =41mmHg) and relaxed (R) state PolyHb (M W =26.33MDa and P50 =0.66mmHg). By maintaining Hb in either the T- or R-state during the polymerization reaction, we were able to synthesize ultrahigh molecular weight PolyHbs in distinct quaternary states with no tetrameric Hb, high viscosity, low colloid osmotic pressure and the ability to maintain O2 dissociation, CO association and NO dioxygenation reactions. The PolyHbs elicited some in vitro RBC aggregation that was less than 6% dextran (500kDa) but more than 5% human serum albumin. In vitro, T-state PolybHb autoxidized faster than R-state PolybHb as expected from previously reported studies, conversely, when administered to guinea pigs as a 20% exchange transfusion, R-state PolybHb oxidized faster and to a greater extent than T-state PolybHb, suggesting a more complex oxidative processes in vivo. Our findings also demonstrate that T-state PolybHb exhibited a longer circulating half-life, slower clearance and longer systemic exposure time compared to R-state PolybHb. JF - Biomaterials AU - Buehler, Paul W AU - Zhou, Yipin AU - Cabrales, Pedro AU - Jia, Yiping AU - Sun, Guoyong AU - Harris, David R AU - Tsai, Amy G AU - Intaglietta, Marcos AU - Palmer, Andre F AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, MD 20892, USA, palmer.351@osu.edu Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 3723 EP - 3735 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 31 IS - 13 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Hemoglobin KW - Red blood cell KW - Blood substitute KW - Oxygen carrier KW - Polymerized hemoglobin KW - Transfusion KW - Dextran KW - Polymerization KW - Colloids KW - Erythrocytes KW - human serum albumin KW - Developmental stages KW - Osmotic pressure KW - Pharmacokinetics KW - Oxygen KW - Viscosity KW - Molecular weight KW - Nitric oxide KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877574646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Synthesis%2C+biophysical+properties+and+pharmacokinetics+of+ultrahigh+molecular+weight+tense+and+relaxed+state+polymerized+bovine+hemoglobins&rft.au=Buehler%2C+Paul+W%3BZhou%2C+Yipin%3BCabrales%2C+Pedro%3BJia%2C+Yiping%3BSun%2C+Guoyong%3BHarris%2C+David+R%3BTsai%2C+Amy+G%3BIntaglietta%2C+Marcos%3BPalmer%2C+Andre+F&rft.aulast=Buehler&rft.aufirst=Paul&rft.date=2010-05-01&rft.volume=31&rft.issue=13&rft.spage=3723&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2010.01.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Dextran; Polymerization; Colloids; Erythrocytes; Developmental stages; human serum albumin; Transfusion; Osmotic pressure; Pharmacokinetics; Hemoglobin; Oxygen; Viscosity; Molecular weight; Nitric oxide DO - http://dx.doi.org/10.1016/j.biomaterials.2010.01.072 ER - TY - GEN T1 - Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2009. NIH Publication No. 10-7583 AN - 851231837; ED514371 AB - Monitoring the Future (MTF) is a long-term study of American adolescents, college students, and adults through age 50. It has been conducted annually by the University of Michigan's Institute for Social Research since its inception in 1975. It is supported under a series of investigator-initiated, competing research grants from the National Institute on Drug Abuse. The need for a study such as MTF is clear. Substance use by American young people has proven to be a rapidly changing phenomenon, requiring frequent assessments and reassessments. Since the mid-1960s, when it burgeoned in the general youth population, illicit drug use has remained a major concern for the nation. Smoking, drinking, and illicit drug use are leading causes of morbidity and mortality, both during adolescence as well as later in life. How vigorously the nation responds to teenage substance use, how accurately it identifies the emerging substance abuse problems, and how well it comes to understand the effectiveness of policy and intervention efforts largely depend on the ongoing collection of valid and reliable data. Monitoring the Future is designed to generate such data in order to provide an accurate picture of what is happening in this domain and why, and has served that function well for the past 34 years. Policy discussions in the media; in government, education, and public health institutions; and elsewhere have been informed by the ready availability of extensive and accurate information from the study relating to a large number of substances. The 2009 MTF survey encompassed over 46,000 eighth-, 10th-, and 12th-grade students in almost 400 secondary schools nationwide. The first published results are presented in this report. Recent trends in the use of licit and illicit drugs are emphasized, as well as trends in the levels of perceived risk and personal disapproval associated with each drug. This study has shown these beliefs and attitudes to be particularly important in explaining trends in use. In addition, trends in the perceived availability of each drug are presented. (Contains 17 tables and 7 footnotes.) [For the related reports, see "Volume I" (ED514370), "Volume II" (ED514367), and "HIV/AIDS: Risk & Protective Behaviors among American Young Adults" (ED514378).] AU - Johnston, Lloyd D. AU - O'Malley, Patrick M. AU - Bachman, Jerald G. AU - Schulenberg, John E. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 83 PB - National Institutes of Health. US Department of Health and Human Services, 9000 Rockville Pike, Bethesda, MD 20892. KW - ERIC, Resources in Education (RIE) KW - Elementary Secondary Education KW - Grade 10 KW - Grade 12 KW - Grade 8 KW - High Schools KW - Secondary Education KW - Substance Abuse KW - Student Characteristics KW - National Surveys KW - Smoking KW - Public Health KW - Federal Programs KW - Health Behavior KW - Student Behavior KW - Trend Analysis KW - Adolescents KW - Social Environment KW - Predictor Variables KW - Drinking KW - Gender Differences KW - Stimulants KW - Narcotics KW - Racial Differences KW - Secondary School Students KW - Longitudinal Studies KW - Risk KW - Inhalants KW - Prevention KW - Epidemiology KW - Student Attitudes KW - Incidence KW - Drug Use KW - Student Surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851231837?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - CPAPER T1 - Skin Injury Experienced During MRI Scans: Measurements of Body Coil Electric Field T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754272078; 5812120 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Rajan, Sunder AU - Zanchi, Marta AU - Bassen, Howard AU - Gaug, Joshua AU - Hardy, Paul Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Skin KW - Electric fields KW - Injuries KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754272078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Skin+Injury+Experienced+During+MRI+Scans%3A+Measurements+of+Body+Coil+Electric+Field&rft.au=Rajan%2C+Sunder%3BZanchi%2C+Marta%3BBassen%2C+Howard%3BGaug%2C+Joshua%3BHardy%2C+Paul&rft.aulast=Rajan&rft.aufirst=Sunder&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Objective Assessment of T2-Based Liver Lesion Classifiers T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754265666; 5810592 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Graff, Christian AU - Clarkson, Eric AU - Altbach, Maria Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Lesions KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754265666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Objective+Assessment+of+T2-Based+Liver+Lesion+Classifiers&rft.au=Graff%2C+Christian%3BClarkson%2C+Eric%3BAltbach%2C+Maria&rft.aulast=Graff&rft.aufirst=Christian&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Maximum Likelihood Method for Partial Volume Segmentation of Magnitude Breast MR Data T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257399; 5814078 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Freed, Melanie AU - Graff, Christian AU - Badano, Aldo AU - Altbach, Maria AU - de Zwart, Jacco AU - Duyn, Jeff Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Data processing KW - Segmentation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=A+Maximum+Likelihood+Method+for+Partial+Volume+Segmentation+of+Magnitude+Breast+MR+Data&rft.au=Freed%2C+Melanie%3BGraff%2C+Christian%3BBadano%2C+Aldo%3BAltbach%2C+Maria%3Bde+Zwart%2C+Jacco%3BDuyn%2C+Jeff&rft.aulast=Freed&rft.aufirst=Melanie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Preliminary Results of a Physical Phantom for Quantitative Assessment of Breast MRI T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754257051; 5809272 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Freed, Melanie AU - de Zwart, Jacco AU - Loud, Jennifer AU - El Khouli, Riham AU - Greene, Mark AU - Gallas, Brandon AU - Myers, Kyle AU - Duyn, Jeff AU - Bluemke, David AU - Badano, Aldo Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754257051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Preliminary+Results+of+a+Physical+Phantom+for+Quantitative+Assessment+of+Breast+MRI&rft.au=Freed%2C+Melanie%3Bde+Zwart%2C+Jacco%3BLoud%2C+Jennifer%3BEl+Khouli%2C+Riham%3BGreene%2C+Mark%3BGallas%2C+Brandon%3BMyers%2C+Kyle%3BDuyn%2C+Jeff%3BBluemke%2C+David%3BBadano%2C+Aldo&rft.aulast=Freed&rft.aufirst=Melanie&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Optimization of a 3D Dixon MR Imaging Techniques for Fat / Water Quantitation T2 - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AN - 754250757; 5813607 JF - 19th Joint Annual Meeting ISMRM- ESMRMB SMRT (ISMRM 2010) AU - Rajan, Sunder AU - Thomasson, David AU - Ouwerkerk, Ronald AU - Liu, Songtao AU - Gharib, Ahmed Y1 - 2010/05/01/ PY - 2010 DA - 2010 May 01 KW - Magnetic resonance imaging KW - Quantitation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754250757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.atitle=Optimization+of+a+3D+Dixon+MR+Imaging+Techniques+for+Fat+%2F+Water+Quantitation&rft.au=Rajan%2C+Sunder%3BThomasson%2C+David%3BOuwerkerk%2C+Ronald%3BLiu%2C+Songtao%3BGharib%2C+Ahmed&rft.aulast=Rajan&rft.aufirst=Sunder&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Joint+Annual+Meeting+ISMRM-+ESMRMB+SMRT+%28ISMRM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/10/program/10ProgramBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Prescription Medication Cost-Related Non-adherence among Medicare CAHPS Respondents: Disparity by Hispanic Ethnicity AN - 754136306; 201020944 AB - Purpose. We examined whether there was disparity in prescription medication cost-related non-adherence (CRN) by Hispanic ethnicity among Medicare enrollees. Methods. Multivariate logistic regression, adjusting for race, other socio-demographic variables, health status, health care utilization, and patient rating of their personal physician, was used to examine association of Hispanic ethnicity with CRN using cross-sectional data from Medicare's Consumer Assessment of Healthcare Providers and Systems (CAHPS) survey (data collected in Spring 2007). Results. Hispanic respondents constituted 6.9% (unweighted n=22,304) of the analytic sample (unweighted n=272,701; response rate = 48%). Overall, 13.4% of respondents reported CRN; among Hispanics and non-Hispanics, 20.3% and 12.9% reported CRN, respectively, p<.0001. Adjusted odds ratio (95% CI) of reporting CRN in the past six months was 1.18 (1.08, 1.29) for Hispanic compared with non-Hispanic respondents. Conclusions. Hispanic ethnicity was significantly associated with CRN. More research is needed to understand interventions to eliminate the disparity for this minority group. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Frankenfield, Diane L AU - Wei, Iris I AU - Anderson, Karyn K AU - Howell, Benjamin L AU - Waldo, Daniel AU - Sekscenski, Edward AD - Centers for Medicare and Medicaid Services, Office of Research, Development, and Information, 7500 Security Blvd., Mailstop C3-21-28, Baltimore, MD 21244; (410) 786-7293 E-mail: diane.frankenfield@cms.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 518 EP - 543 PB - John Hopkins University Press, Baltimore MD VL - 21 IS - 2 SN - 1049-2089, 1049-2089 KW - Disparities, Hispanic, ethnicity, race, minority, cost-related non-adherence, Medicare KW - Prescriptions KW - Ethnicity KW - Adherence KW - Hispanic people KW - Medicare KW - Helpseeking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Prescription+Medication+Cost-Related+Non-adherence+among+Medicare+CAHPS+Respondents%3A+Disparity+by+Hispanic+Ethnicity&rft.au=Frankenfield%2C+Diane+L%3BWei%2C+Iris+I%3BAnderson%2C+Karyn+K%3BHowell%2C+Benjamin+L%3BWaldo%2C+Daniel%3BSekscenski%2C+Edward&rft.aulast=Frankenfield&rft.aufirst=Diane&rft.date=2010-05-01&rft.volume=21&rft.issue=2&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-08-09 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Hispanic people; Ethnicity; Medicare; Adherence; Prescriptions; Helpseeking ER - TY - BOOK T1 - Health Disparities in Manufacturing AN - 754080645; 2010-593451 AB - One of the central features of the contemporary U.S. workforce is that it is increasingly diverse, reflecting the changing demographic characteristics of our nation. In 2008, 15.6% of the U.S. employed labor force identified themselves as foreign-born: 19.2% were white non-Hispanic or Latino, 49.4% were of Hispanic ethnicity,1 and an estimated 12.8% were employed in the Manufacturing Sector. In 2008, 3.8% of all employed workers were age 16-19 (1.4% in Manufacturing) and 18.4% were over 55 (18.1% in Manufacturing). Approximately 4% of workers in the U.S. labor force identify themselves as disabled. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2010, 2 pp. AU - National Occupational Research Agenda Y1 - 2010/05// PY - 2010 DA - May 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Manufacturing and heavy industry - Manufacturing and manufactured goods KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Health conditions and policy - Health and health policy KW - Population groups, population policy, and demographics - Disabled KW - Labor conditions and policy - Work and labor KW - Disabled KW - Manufacturing KW - Demographics KW - Labor KW - Working conditions KW - Public health KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754080645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Occupational+Research+Agenda&rft.aulast=National+Occupational+Research+Agenda&rft.aufirst=&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Health+Disparities+in+Manufacturing&rft.title=Health+Disparities+in+Manufacturing&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2010-146/pdfs/2010-146.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-09-10 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Recommendations for a New Rock Dusting Standard to Prevent Coal Dust Explosions in Intake Airways AN - 754078898; 2010-564695 AB - The workings of a bituminous coal mine produce explosive coal dust for which adding rock dust can reduce the potential for explosions. Accordingly, guidelines have been established by the Mine Safety and Health Administration (MSHA) about the relative proportion of rock dust that must be present in a mine's intake and return airways. Tables, Figures, Appendixes, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2010, 59 pp. AU - Cashdollar, Kenneth L AU - Green, Gregory L AU - Harris, Marcia L AU - Harteis, Samuel P AU - Man, Chi-Keung AU - Sapko, Michael J AU - Weiss, Eric S Y1 - 2010/05// PY - 2010 DA - May 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Environment and environmental policy - Mining and mineral resources KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Social conditions and policy - Public safety and security KW - Safety measures KW - Standards KW - Mining industry KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754078898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Cashdollar%2C+Kenneth+L%3BGreen%2C+Gregory+L%3BHarris%2C+Marcia+L%3BHarteis%2C+Samuel+P%3BMan%2C+Chi-Keung%3BSapko%2C+Michael+J%3BWeiss%2C+Eric+S&rft.aulast=Cashdollar&rft.aufirst=Kenneth&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Recommendations+for+a+New+Rock+Dusting+Standard+to+Prevent+Coal+Dust+Explosions+in+Intake+Airways&rft.title=Recommendations+for+a+New+Rock+Dusting+Standard+to+Prevent+Coal+Dust+Explosions+in+Intake+Airways&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/mining/pubs/pdfs/2010-151.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-08-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Catastrophic Incidents in Manufacturing AN - 754078811; 2010-593450 AB - Explosions, fires, building structural failures and other catastrophic incidents during the handling and processing of chemicals in manufacturing industries cause worker deaths, injuries, significant economic losses and serious impacts on the surrounding communities and environment each year. Notorious and tragic catastrophic incidents (human toll in the thousands of affected lives) have triggered legislation and regulation to prevent and mitigate such incidents. Reports from investigations of catastrophic incidents can be found on the U. S. Chemical Safety and Hazard Investigations Board web site (www.csb.gov). JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2010, 2 pp. AU - National Occupational Research Agenda Y1 - 2010/05// PY - 2010 DA - May 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Manufacturing and heavy industry - Manufacturing and manufactured goods KW - Social conditions and policy - Public safety and security KW - Environment and environmental policy - Radioactive and dangerous substances KW - Law and ethics - Law and jurisprudence KW - United States KW - Chemicals KW - Accidents KW - Hazardous materials KW - Manufacturing KW - Regulation KW - Legislation KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754078811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Occupational+Research+Agenda&rft.aulast=National+Occupational+Research+Agenda&rft.aufirst=&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Catastrophic+Incidents+in+Manufacturing&rft.title=Catastrophic+Incidents+in+Manufacturing&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2010-149/pdfs/2010-149.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-09-10 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - SuppNotes - NIOSH Publication No. 2010-149: N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Occupational Emerging Risks AN - 754077565; 2010-564696 AB - An emerging risk is a recently discovered actual or potential hazard to people and property. The hazard is typically recognized by empirical means including engineering analyses, accident or injury investigations, toxicological studies, and epidemiological studies. Newly synthesized materials for which empirical studies are lacking may be identified as emerging issues because of the nature and physical characteristics of the materials. Occupational exposures to newly synthesized materials, as an example, is an emerging risk. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2010, 2 pp. AU - National Inst Occupational Safety and Health Y1 - 2010/05// PY - 2010 DA - May 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Social conditions and policy - Public safety and security KW - Environment and environmental policy - Radioactive and dangerous substances KW - Investigation KW - Risk KW - Accidents KW - Hazardous materials KW - Safety measures KW - Working conditions KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754077565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=National+Inst+Occupational+Safety+and+Health&rft.aulast=National+Inst+Occupational+Safety+and+Health&rft.aufirst=&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Occupational+Emerging+Risks&rft.title=Occupational+Emerging+Risks&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2010-148/pdfs/2010-148.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-08-09 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - Last updated - 2016-09-28 ER - TY - BOOK T1 - Use of Workers' Compensation Data for Occupational Injury & Illness Prevention AN - 754076818; 2010-593449 AB - The Workers' Compensation Data Use Workshop was convened to discuss opportunities for collaboration in the analysis of WC data in order to help reduce the risks of occupational injuries and illnesses. Stakeholders from private insurance carriers, insurance associations, self-insured corporations, academic institutions and government agencies participated. Presentations described differences among state laws, proper interpretation of common industry terms, proprietary interests in insurance data, public release of internal analyses, and methods for linking WC data with other health and employment data. Tables, Figures, References. JF - United States National Institute for Occupational Safety and Health (NIOSH), May 2010, 192 pp. AU - Schnorr, Teresa M AU - Utterback, David F Y1 - 2010/05// PY - 2010 DA - May 2010 PB - United States National Institute for Occupational Safety and Health (NIOSH) KW - Labor conditions and policy - Work and labor KW - Social conditions and policy - Public safety and security KW - Labor conditions and policy - Labor conditions, wages, salaries, and benefits KW - Business and service sector - Insurance KW - Manufacturing and heavy industry - Industry and industrial policy KW - Business and service sector - Business and business enterprises KW - Workers' compensation KW - Accidents KW - Corporations KW - Safety measures KW - Insurance KW - Industry KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754076818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Schnorr%2C+Teresa+M%3BUtterback%2C+David+F&rft.aulast=Schnorr&rft.aufirst=Teresa&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Use+of+Workers%27+Compensation+Data+for+Occupational+Injury+%26+Illness+Prevention&rft.title=Use+of+Workers%27+Compensation+Data+for+Occupational+Injury+%26+Illness+Prevention&rft.issn=&rft_id=info:doi/ L2 - http://www.cdc.gov/niosh/docs/2010-152/pdfs/2010-152.pdf LA - English DB - PAIS Index N1 - Date revised - 2010-09-10 N1 - Publication note - United States National Institute for Occupational Safety and Health (NIOSH), 2010 N1 - SuppNotes - NIOSH Publication No. 2010-152 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Digital 3-D headforms with facial features representative of the current US workforce AN - 753657292; 13185920 AB - Existing headforms are based on anthropometric data collected over 30 years ago. In 2003, the National Institute for Occupational Safety and Health conducted an anthropometric survey of 3997 respirator users, of which 1013 subjects were scanned with a Cyberware 3-D Rapid Digitizer. The objective of this study was to create headforms representative of the current US workforce. Ten facial dimensions relevant to respirator fit were chosen for defining a principal component analysis model, which divides the user population into five face-size categories. Mean facial dimensions were then computed to target the ideal facial dimensions for each size category. Five scans in each category were chosen and averaged to construct a representative headform for each size category. Five digital 3-D headforms were developed: small, medium, large, long/narrow and short/wide. All dimensions are within 3mm of the computed means for the sample population in each size category. Statement of Relevance: This manuscript describes a new approach to constructing headforms that takes into account the facial form (size and shape) of the US workforce. These headforms could be incorporated into respirator research, certification standards and design in efforts to reduce the risk of injury or illness caused by inhalation hazards. JF - Ergonomics AU - Zhuang, Ziqing AU - Benson, Stacey AU - Viscusi, Dennis AD - National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Pittsburgh, PA, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 661 EP - 671 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 53 IS - 5 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Inhalation KW - Injuries KW - principal components analysis KW - Occupational safety KW - Protective equipment KW - certification KW - risk reduction KW - USA KW - Respirators KW - Ergonomics KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753657292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Digital+3-D+headforms+with+facial+features+representative+of+the+current+US+workforce&rft.au=Zhuang%2C+Ziqing%3BBenson%2C+Stacey%3BViscusi%2C+Dennis&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2010-05-01&rft.volume=53&rft.issue=5&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140130903581656 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Inhalation; risk reduction; certification; Injuries; principal components analysis; Occupational safety; Respirators; Protective equipment; Ergonomics; USA DO - http://dx.doi.org/10.1080/00140130903581656 ER - TY - JOUR T1 - Evaluation of a Preventive Program to Reduce Sensitization at a Beryllium Metal, Oxide, and Alloy Production Plant AN - 746310291; 13196395 AB - Objective: We evaluated a workplace preventive program's effectiveness, which emphasized skin and respiratory protection, workplace cleanliness, and beryllium migration control in lowering beryllium sensitization. Methods: We compared sensitization prevalence and incidence rates for workers hired before and after the program using available cross sectional and longitudinal surveillance data. Results: Sensitization prevalence was 8.9% for the Pre-Program Group and 2.1% for the Program Group. The sensitization incidence rate was 3.7/1000 person-months for the Pre-Program Group and 1.7/1000 person-months for the Program Group. After making adjustments for potential selection and information bias, sensitization prevalence for the Pre-Program Group was 3.8 times higher (95% CI = 1.5 to 9.3) than the Program Group. The sensitization incidence rate ratio comparing the Pre-Program Group to the Program Group was 1.6 (95% CI = 0.8 to 3.6). Conclusions: This preventive program reduced the prevalence of but did not eliminate beryllium sensitization. JF - Journal of Occupational and Environmental Medicine AU - Bailey, R L AU - Thomas, CA AU - Deubner, D C AU - Kent AU - Kreiss, K AU - Schuler, C R AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505, USA, RLBailey@cdc.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 505 EP - 512 VL - 52 IS - 5 SN - 1076-2752, 1076-2752 KW - Toxicology Abstracts KW - Metals KW - Workers KW - Data processing KW - Skin KW - Beryllium KW - oxides KW - alloys KW - Migration KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746310291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Evaluation+of+a+Preventive+Program+to+Reduce+Sensitization+at+a+Beryllium+Metal%2C+Oxide%2C+and+Alloy+Production+Plant&rft.au=Bailey%2C+R+L%3BThomas%2C+CA%3BDeubner%2C+D+C%3BKent%3BKreiss%2C+K%3BSchuler%2C+C+R&rft.aulast=Bailey&rft.aufirst=R&rft.date=2010-05-01&rft.volume=52&rft.issue=5&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181d6c338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Workers; Metals; Skin; Data processing; Beryllium; oxides; alloys; Migration DO - http://dx.doi.org/10.1097/JOM.0b013e3181d6c338 ER - TY - JOUR T1 - Analysis of applied forces and electromyography of back and shoulders muscles when performing a simulated hand scaling task AN - 746306221; 12963068 AB - Hand scaling is a physically demanding task responsible for numerous overexertion injuries in underground mining. Scaling requires the miner to use a long pry bar to remove loose rock, reducing the likelihood of rock fall injuries. The experiments described in this article simulated "rib" scaling (scaling a mine wall) from an elevated bucket to examine force generation and electromyographic responses using two types of scaling bars (steel and fiberglass-reinforced aluminum) at five target heights ranging from floor level to 176 cm. ten male and six female subjects were tested in separate experiments. Peak and average force applied at the scaling bar tip and normalized electromyography (EMG) of the left and right pairs of the deltoid and erectores spinae muscles were obtained. Work height significantly affected peak prying force during scaling activities with highest force capacity at the lower levels. Bar type did not affect force generation. However, use of the lighter fiberglass bar required significantly more muscle activity to achieve the same force. Results of these studies suggest that miners scale points on the rock face that are below their knees, and reposition the bucket as often as necessary to do so. JF - Applied Ergonomics AU - Porter, William AU - Gallagher, Sean AU - Torma-Krajewski, Janet AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, USA, wlporter@cdc.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 411 EP - 416 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 41 IS - 3 SN - 0003-6870, 0003-6870 KW - Health & Safety Science Abstracts KW - Injuries KW - Occupational safety KW - Muscles KW - Mines KW - working conditions KW - scaling KW - Fiberglass KW - Aluminum KW - Steel KW - Mining KW - Ergonomics KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746306221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Analysis+of+applied+forces+and+electromyography+of+back+and+shoulders+muscles+when+performing+a+simulated+hand+scaling+task&rft.au=Porter%2C+William%3BGallagher%2C+Sean%3BTorma-Krajewski%2C+Janet&rft.aulast=Porter&rft.aufirst=William&rft.date=2010-05-01&rft.volume=41&rft.issue=3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2009.09.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Injuries; Fiberglass; Aluminum; Occupational safety; Muscles; Mining; Steel; Mines; Ergonomics; working conditions; scaling DO - http://dx.doi.org/10.1016/j.apergo.2009.09.004 ER - TY - RPRT T1 - Research Associate Dies from Burns Sustained While Working with a Pyrophoric Chemical AN - 746164215; 13109883 AB - A 23-year-old female research associate died from burn injuries sustained in a research laboratory fire. The victim was using a syringe and needle to extract a pyrophoric chemical (t-butyl lithium) from a bottle. The plunger came out of the syringe barrel and the t-butyl lithium ignited on contact with room air. The chemical splashed onto the victim's clothing and set them on fire. She was not wearing a laboratory coat at the time of the incident. There was no written documentation that the victim had received formal training on the safe use of pyrophoric chemicals. The CA/FACE investigator determined that in order to prevent future incidents, employers with research laboratories should ensure that: Laboratory personnel follow proper procedures when using pyrophoric chemicals. Laboratory personnel wear appropriate clothing and personal protective equipment (PPE) when working with pyrophoric chemicals. Whenever possible, laboratory personnel consider the use of alternative chemicals that are not pyrophoric. JF - Research Associate Dies from Burns Sustained While Working with a Pyrophoric Chemical. [np]. May 2010. AU - Anonymous Y1 - 2010/05// PY - 2010 DA - May 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Burns KW - Chemical spills KW - Fires KW - Injuries KW - Training KW - Protective equipment KW - syringes KW - wear KW - Lithium KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Research+Associate+Dies+from+Burns+Sustained+While+Working+with+a+Pyrophoric+Chemical&rft.title=Research+Associate+Dies+from+Burns+Sustained+While+Working+with+a+Pyrophoric+Chemical&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Two Hospital Workers Die when a Motor Vehicle Crashes into a Hospital Lobby - Massachusetts AN - 746164141; 13109884 AB - On October 15, 2007, a 58-year-old male physician (victim 1) and a 59-year-old female receptionist (victim 2) were fatally injured when a motor vehicle driven by an elderly patient crashed into their workplace, a hospital-based radiation therapy unit. The driver of the motor vehicle entered a pedestrian walkway after failing to negotiate a turn in the hospital's driveway. The vehicle then crashed through two sets of glass doors and entered the radiation therapy unit's lobby. The car came to rest after striking the lobby reception desk. A total of four workers were struck in the collision. The Massachusetts FACE Program concluded that to prevent similar occurrences in the future, employers and property managers should: Evaluate the layout of parking lots and driveways to determine locations susceptible to damage from vehicle intrusion; Consider Installing exterior perimeter security barriers to protect employees and minimize building and structural damage from vehicle intrusion; and Evaluate and modify interior floor plans to protect employees from vehicle intrusion. In addition, policy makers and planners should: Consider developing guidelines on preventing vehicle intrusions into buildings. JF - Two Hospital Workers Die when a Motor Vehicle Crashes into a Hospital Lobby - Massachusetts. [np]. May 2010. AU - Anonymous Y1 - 2010/05// PY - 2010 DA - May 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Radiation therapy KW - USA, Massachusetts KW - Motor vehicles KW - pedestrians KW - security KW - Buildings KW - Accidents KW - guidelines KW - elderly KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-05-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Two+Hospital+Workers+Die+when+a+Motor+Vehicle+Crashes+into+a+Hospital+Lobby+-+Massachusetts&rft.title=Two+Hospital+Workers+Die+when+a+Motor+Vehicle+Crashes+into+a+Hospital+Lobby+-+Massachusetts&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Interaction between DNA Polymerase [lambda] and Anticancer Nucleoside Analogs AN - 746161284; 13137739 AB - The anticancer activity of cytarabine (AraC) and gemcitabine (dFdC) is thought to result from chain termination after incorporation into DNA. To investigate their incorporation into DNA at atomic level resolution, we present crystal structures of human DNA polymerase [lambda] (Pol [lambda]) bound to gapped DNA and containing either AraC or dFdC paired opposite template dG. These structures reveal that AraC and dFdC can bind within the nascent base pair binding pocket of Pol [lambda]. Although the conformation of the ribose of AraCTP is similar to that of normal dCTP, the conformation of dFdCTP is significantly different. Consistent with these structures, Pol [lambda] efficiently incorporates AraCTP but not dFdCTP. The data are consistent with the possibility that Pol [lambda] could modulate the cytotoxic effect of AraC. JF - Journal of Biological Chemistry AU - Garcia-Diaz, Miguel AU - Murray, Michael S AU - Kunkel, Thomas A AU - Chou, Kai-ming AD - Laboratory of Structural Biology and Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, the Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 16874 EP - 16879 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA VL - 285 IS - 22 SN - 0021-9258, 0021-9258 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - nucleoside analogs KW - Cytotoxicity KW - Data processing KW - cytarabine KW - DNA-directed DNA polymerase KW - Ribose KW - Crystal structure KW - gemcitabine KW - Conformation KW - Antitumor activity KW - Base pairs KW - N 14840:Antisense, Nucleotide Analogs KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746161284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Interaction+between+DNA+Polymerase+%5Blambda%5D+and+Anticancer+Nucleoside+Analogs&rft.au=Garcia-Diaz%2C+Miguel%3BMurray%2C+Michael+S%3BKunkel%2C+Thomas+A%3BChou%2C+Kai-ming&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2010-05-01&rft.volume=285&rft.issue=22&rft.spage=16874&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M109.094391 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - nucleoside analogs; Cytotoxicity; cytarabine; Data processing; DNA-directed DNA polymerase; Ribose; Crystal structure; gemcitabine; Base pairs; Antitumor activity; Conformation DO - http://dx.doi.org/10.1074/jbc.M109.094391 ER - TY - JOUR T1 - EVALUATION OF THE PETRIFILM DRY REHYDRATABLE FILM FOR THE ENUMERATION OF YEASTS AND MOULDS IN NATURALLY CONTAMINATED FOODS AN - 746005688; 12854744 AB - Two hundred thirty-seven samples from six food groups (tree nuts, grains and grain products, dried fruits, fresh produce, fruit juice and dairy products) were tested for levels of fungal contamination using the Petrifilm dry rehydratable film for yeast and mould (PYM ) enumeration (3M Microbiology, St. Paul, MN) and the Food and Drug Administration (FDA) official method. Results indicated that PYM performed very well for all tested commodities giving YM counts similar to those of the FDA method. Statistical analysis of the data (t-test) revealed no significant differences between the two methods for all foods tested. Linear regression analysis showed that the correlation coefficients between the two methods were over 0.90 for 91% of the commodities tested. Some difficulties were encountered during counting of the colonies on PYM as yeast colonies on this medium tend to be very small with rather faded colorations. JF - Journal of Food Safety AU - Tournas, Valerie H AU - FELICIANO, LIZANEL AU - KATSOUDAS, EUGENIA J AD - 1Center for Food Safety and Applied NutritionFood and Drug Administration5100 Paint Branch Parkway, College Park, MD 20740 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 506 EP - 514 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 30 IS - 2 SN - 0149-6085, 0149-6085 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Fruits KW - Data processing KW - Dairy products KW - Statistical analysis KW - Nuts KW - Enumeration KW - Food contamination KW - Fruit juices KW - Colonies KW - Grain KW - Regression analysis KW - Manganese KW - A 01330:Food Microbiology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746005688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Safety&rft.atitle=EVALUATION+OF+THE+PETRIFILM+DRY+REHYDRATABLE+FILM+FOR+THE+ENUMERATION+OF+YEASTS+AND+MOULDS+IN+NATURALLY+CONTAMINATED+FOODS&rft.au=Tournas%2C+Valerie+H%3BFELICIANO%2C+LIZANEL%3BKATSOUDAS%2C+EUGENIA+J&rft.aulast=Tournas&rft.aufirst=Valerie&rft.date=2010-05-01&rft.volume=30&rft.issue=2&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Safety&rft.issn=01496085&rft_id=info:doi/10.1111%2Fj.1745-4565.2010.00223.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 13 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Fruit juices; Fruits; Colonies; Data processing; Regression analysis; Statistical analysis; Dairy products; Grain; Nuts; Enumeration; Food contamination; Manganese DO - http://dx.doi.org/10.1111/j.1745-4565.2010.00223.x ER - TY - JOUR T1 - Highly Persistent and Effective Prime/Boost Regimens against Tuberculosis That Use a Multivalent Modified Vaccine Virus Ankara-Based Tuberculosis Vaccine with Interleukin-15 as a Molecular Adjuvant AN - 745978611; 12845379 AB - Novel immunization strategies are needed to enhance the global control of tuberculosis (TB). In this study, we assessed the immunizing activity of a recombinant modified vaccinia Ankara (MVA) construct (MVA/IL-15/5Mtb) which overexpresses five Mycobacterium tuberculosis antigens (antigen 85A, antigen 85B, ESAT6, HSP60, and Mtb39), as well as the molecular adjuvant interleukin-15 (IL-15). Homologous prime/boost studies showed that the MVA/IL-15/5Mtb vaccine induced moderate but highly persistent protective immune responses for at least 16 months after the initial vaccination and that the interval between the prime and boost did not significantly alter vaccine-induced antituberculosis protective immunity. At 16 months, when the Mycobacterium bovis BCG and MVA/IL-15/5Mtb vaccine-induced protection was essentially equivalent, the protective responses after a tuberculous challenge were associated with elevated levels of gamma interferon (IFN-), IL-17F, Cxcl9, and Cxcl10. To amplify the immunizing potential of the MVA/IL-15/5Mtb vaccine, a heterologous prime/boost regimen was tested using an ESAT6-antigen 85B (E6-85) fusion protein formulated in dimethyldiotacylammonium bromide/monophosphoryl lipid A (DDA/MPL) adjuvant as the priming vaccine and the MVA/IL-15/5Mtb recombinant virus as the boosting agent. When MVA/IL-15/5Mtb vaccine boosting was done at 2 or 6 months following the final fusion protein injections, the prime/boost regimen evoked protective responses against an aerogenic M. tuberculosis challenge which was equivalent to that induced by BCG immunization. Long-term memory after immunization with the E6-85-MVA/IL-15/5Mtb combination regimen was associated with the induction of monofunctional CD4 and CD8 IFN--producing T cells and multifunctional CD4 and CD8 T cells expressing IFN-/tumor necrosis factor alpha (TNF-), TNF-/IL-2, and IFN-/TNF-/IL-2. In contrast, BCG-induced protection was characterized by fewer CD4 and CD8 monofunctional T cells expressing IFN- and only IFN-/TNF- and IFN-/TNF-/IL-2 expressing multifunctional T (MFT) cells. Taken together, these results suggest that a heterologous prime/boost protocol using an MVA-based tuberculosis vaccines to boost after priming with TB protein/adjuvant preparations should be considered when designing long-lived TB immunization strategies. JF - Clinical and Vaccine Immunology AU - Kolibab, Kristopher AU - Yang, Amy AU - Derrick, Steven C AU - Waldmann, Thomas A AU - Perera, Liyanage P AU - Morris, Sheldon L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland 20892, sheldon.morris@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 793 EP - 801 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 17 IS - 5 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Adjuvants KW - Antigen 85B KW - BCG KW - CD4 antigen KW - CD8 antigen KW - CXCL10 protein KW - Fusion protein KW - Hsp60 protein KW - Immune response KW - Immunity KW - Immunization KW - Interferon KW - Interleukin 15 KW - Interleukin 2 KW - Long term memory KW - Lymphocytes T KW - Monophosphoryl lipid A KW - Tuberculosis KW - Tumor necrosis factor-a KW - Vaccination KW - Vaccines KW - Vaccinia KW - bromides KW - g-Interferon KW - Mycobacterium bovis KW - Mycobacterium tuberculosis KW - V 22350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745978611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Highly+Persistent+and+Effective+Prime%2FBoost+Regimens+against+Tuberculosis+That+Use+a+Multivalent+Modified+Vaccine+Virus+Ankara-Based+Tuberculosis+Vaccine+with+Interleukin-15+as+a+Molecular+Adjuvant&rft.au=Kolibab%2C+Kristopher%3BYang%2C+Amy%3BDerrick%2C+Steven+C%3BWaldmann%2C+Thomas+A%3BPerera%2C+Liyanage+P%3BMorris%2C+Sheldon+L&rft.aulast=Kolibab&rft.aufirst=Kristopher&rft.date=2010-05-01&rft.volume=17&rft.issue=5&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00006-10 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 29 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Monophosphoryl lipid A; g-Interferon; Interleukin 2; Long term memory; Vaccinia; Immunity; Adjuvants; CD8 antigen; bromides; Tumor necrosis factor-a; Vaccination; Immunization; CXCL10 protein; Interferon; Antigen 85B; CD4 antigen; Interleukin 15; BCG; Hsp60 protein; Lymphocytes T; Tuberculosis; Immune response; Vaccines; Fusion protein; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/CVI.00006-10 ER - TY - JOUR T1 - Welding fumes from stainless steel gas metal arc processes contain multiple manganese chemical species AN - 745715090; 13106018 AB - Fumes from a group of gas metal arc welding (GMAW) processes used on stainless steel were generated using three different metal transfer modes and four different shield gases. The objective was to identify and measure manganese (Mn) species in the fumes, and identify processes that are minimal generators of Mn species. The robotic welding system was operated in short-circuit (SC) mode (Ar/CO sub(2) and He/Ar), axial spray (AXS) mode (Ar/O sub(2) and Ar/CO sub(2)), and pulsed axial-spray (PAXS) mode (Ar/O sub(2)). The fumes were analyzed for Mn by a sequential extraction process followed by inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis, and by X-ray diffraction (XRD). Total elemental Mn, iron (Fe), chromium (Cr) and nickel (Ni) were separately measured after aqua regia digestion and ICP-AES analysis. Soluble Mn super(2+), Fe super(2+), Fe super(3+), and Ni super(2+) in a simple biological buffer (phosphate-buffered saline) were determined at pH 7.2 and 5.0 after 2 h incubation at 37 C by ion chromatography. Results indicate that Mn was present in soluble form, acid-soluble form, and acid-soluble form after reduction by hydroxylamine, which represents soluble Mn super(0) and Mn super(2+) compounds, other Mn super(2+) compounds, and (Mn super(3+) and Mn super(4+)) compounds, respectively. The dominant fraction was the acid-soluble Mn super(2+) fraction, but results varied with the process and shield gas. Soluble Mn mass percent in the fume ranged from 0.2 to 0.9%, acid-soluble Mn super(2+) compounds ranged from 2.6 to 9.3%, and acid plus reducing agent-soluble (Mn super(3+) and Mn super(4+)) compounds ranged from 0.6 to 5.1%. Total Mn composition ranged from 7 to 15%. XRD results showed fumes had a crystalline content of 90-99% Fe sub(3)O sub(4), and showed evidence of multiple Mn super(2+) oxides, but overlaps and weak signals limited identification. Small amounts of the Mn super(2+) in the fume (<0.01 to 6 1% or <0.1 to 6 10 kg ml super(-1)) and Ni super(2+) (<0.01 to 6 0.2% or <0.1 to 6 2 kg ml super(-1)) ions were found in biological buffer media, but amounts were highly dependent on pH and the welding process. Mn generation rates for the fractions were tabulated, and the influence of ozone is discussed. The conclusions are that exposures to welding fumes include multiple Mn species, both soluble and insoluble, and that exposures to Mn species vary with specific processes and shield gases. JF - Journal of Environmental Monitoring AU - Keane, M AU - Stone, S AU - Chen, B AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Rd, Morgantown, WV, 26505, USA Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 1133 EP - 1140 VL - 12 IS - 5 SN - 1464-0325, 1464-0325 KW - Toxicology Abstracts; Environment Abstracts; Pollution Abstracts KW - Heavy metals KW - buffers KW - Nickel KW - hydroxylamines KW - Spectroscopy KW - Digestion KW - Chemical speciation KW - Welding KW - oxides KW - Steel KW - pH effects KW - Manganese KW - pH KW - Ozone KW - Hydroxylamine KW - Environmental monitoring KW - Metals KW - Ions KW - Fumes KW - Chromium KW - Chromatography KW - Sprays KW - X-ray diffraction KW - emission spectroscopy KW - Gases KW - robotics KW - Carbon dioxide KW - Iron KW - stainless steel KW - P 0000:AIR POLLUTION KW - X 24360:Metals KW - ENA 21:Wildlife UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745715090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Welding+fumes+from+stainless+steel+gas+metal+arc+processes+contain+multiple+manganese+chemical+species&rft.au=Keane%2C+M%3BStone%2C+S%3BChen%2C+B&rft.aulast=Keane&rft.aufirst=M&rft.date=2010-05-01&rft.volume=12&rft.issue=5&rft.spage=1133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb922840c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Hydroxylamine; Ions; Fumes; Chromium; Chromatography; Heavy metals; Nickel; X-ray diffraction; Spectroscopy; Digestion; Gases; oxides; Welding; robotics; Carbon dioxide; Manganese; Iron; pH effects; Ozone; stainless steel; Metals; buffers; Sprays; hydroxylamines; emission spectroscopy; Chemical speciation; Steel; pH DO - http://dx.doi.org/10.1039/b922840c ER - TY - JOUR T1 - Evaluation of Mycoplasma Inactivation during Production of Biologics: Egg-Based Viral Vaccines as a Model AN - 744673372; 12676535 AB - Although mycoplasmas are generally considered to be harmless commensals, some mycoplasma species are able to cause infections in pediatric, geriatric, or immunocompromised patients. Thus, accidental contamination of biologics with mycoplasmas represents a potential risk for the health of individuals who receive cell-derived biological and pharmaceutical products. To assess the efficiency of inactivation of mycoplasmas by the agents used in the manufacture of egg-derived influenza vaccines, we carried out a series of experiments aimed at monitoring the viability of mycoplasmas spiked into both chicken allantoic fluid and protein-rich microbiological media and then treated with beta-propiolactone, formalin, cetyltrimethylammonium bromide, Triton X-100, and sodium deoxycholate, which are agents that are commonly used for virus inactivation and disruption of viral particles during influenza vaccine production. Twenty-two mycoplasma species (with one to four strains of each species) were exposed to these inactivating agents at different concentrations. The most efficient inactivation of the mycoplasmas evaluated was observed with either 0.5% Triton X-100 or 0.5% sodium deoxycholate. Cetyltrimethylammonium bromide at concentrations of 0.08% was also able to rapidly inactivate (in less than 30 min) all mycoplasmas tested. In contrast, negligible reductions in mycoplasma titers were observed with 0.0125 to 0.025% formaldehyde. However, increasing the concentration of formaldehyde to 0.1 to 0.2% improved the mycoplasmacidal effect. Incubation of mycoplasmas with 0.1% beta-propiolactone for 1 to 24 h had a marked mycoplasmacidal effect. A comparison of the mycoplasma inactivation profiles showed that strains of selected species (Mycoplasma synoviae, Mycoplasma gallisepticum, Mycoplasma orale, Mycoplasma pneumoniae, and Acholeplasma laidlawii) represent a set of strains that can be utilized to validate the effectiveness of mycoplasma clearance obtained by inactivation and viral purification processes used for the manufacture of an inactivated egg-based vaccine. JF - Applied and Environmental Microbiology AU - Wilson David, Selwyn A AU - Volokhov, Dmitriy V AU - Ye, Zhiping AU - Chizhikov, Vladimir AD - Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, 1401 Rockville Pike, HFM-470, Rockville, Maryland 20852, dmitriy.volokhov@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2718 EP - 2728 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 9 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Allantoic fluid KW - Acholeplasma laidlawii KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials KW - F 06905:Vaccines KW - J 02400:Human Diseases KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744673372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Evaluation+of+Mycoplasma+Inactivation+during+Production+of+Biologics%3A+Egg-Based+Viral+Vaccines+as+a+Model&rft.au=Wilson+David%2C+Selwyn+A%3BVolokhov%2C+Dmitriy+V%3BYe%2C+Zhiping%3BChizhikov%2C+Vladimir&rft.aulast=Wilson+David&rft.aufirst=Selwyn&rft.date=2010-05-01&rft.volume=76&rft.issue=9&rft.spage=2718&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02776-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vaccines; Acholeplasma laidlawii DO - http://dx.doi.org/10.1128/AEM.02776-09 ER - TY - JOUR T1 - Comparison of Statistical Approaches to Evaluate Factors Associated With Metabolic Syndrome AN - 744612819; 12947375 AB - J Clin Hypertens (Greenwich).In statistical analyses, metabolic syndrome as a dependent variable is often utilized in a binary form (presence-absence) where the logistic regression model is used to estimate the odds ratio as the measure of association between health-related factors and metabolic syndrome. Since metabolic syndrome is a common outcome the interpretation of odds ratio as an approximation to prevalence or risk ratio is questionable as it may overestimate its intended target. In addition, dichotomizing a variable that could potentially be treated as discrete may lead to reduced statistical power. In this paper, the authors treat metabolic syndrome as a discrete outcome by defining it as the count of syndrome components. The goal of this study is to evaluate the usefulness of alternative generalized linear models for analysis of metabolic syndrome as a count outcome and compare the results with models that utilize the binary form. Empirical data were used to examine the association between depression and metabolic syndrome. Measures of association were calculated using two approaches; models that treat metabolic syndrome as a binary outcome (the logistic, log-binomial, Poisson, and the modified Poisson regression) and models that utilize metabolic syndrome as discrete-count data (the Poisson and the negative binomial regression). The method that treats metabolic syndrome as a count outcome (Poisson-negative binomial regression model) appears more sensitive in that it is better able to detect associations and hence can serve as an alternative to analyze metabolic syndrome as count dependent variable and provide an interpretable measure of association. JF - Journal of Clinical Hypertension AU - Fekedulegn, Desta AU - Andrew, Michael AU - Violanti, John AU - Hartley, Tara AU - Charles, Luenda AU - Burchfiel, Cecil AD - From the Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV1 Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 365 EP - 373 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 12 IS - 5 SN - 1524-6175, 1524-6175 KW - Risk Abstracts KW - metabolic disorders KW - hypertension KW - depression KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744612819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Hypertension&rft.atitle=Comparison+of+Statistical+Approaches+to+Evaluate+Factors+Associated+With+Metabolic+Syndrome&rft.au=Fekedulegn%2C+Desta%3BAndrew%2C+Michael%3BViolanti%2C+John%3BHartley%2C+Tara%3BCharles%2C+Luenda%3BBurchfiel%2C+Cecil&rft.aulast=Fekedulegn&rft.aufirst=Desta&rft.date=2010-05-01&rft.volume=12&rft.issue=5&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Hypertension&rft.issn=15246175&rft_id=info:doi/10.1111%2Fj.1751-7176.2010.00264.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - metabolic disorders; hypertension; depression DO - http://dx.doi.org/10.1111/j.1751-7176.2010.00264.x ER - TY - JOUR T1 - When the Third World Comes to the First: Ethical Considerations When Working With Hispanic Immigrants AN - 742725235; 201015810 AB - This article briefly reviews concerns related to the 'cultural colonialism' of applying Western biomedical models of research ethics to non-Western groups. The feasibility of alternate ethical models is discussed and found wanting. In practical terms, many academic researchers in the United States are funded by federal agencies and are required to adhere to Title 45, Part 46 of the Code of Federal Regulations, legislation that is clearly grounded in the Western biomedical research tradition. Consequently, the question is not whether this system of ethics should be applied but rather how it can be applied most sensitively, appropriately, and wisely. The remainder of this article discusses of how the authors have attempted to do so in each stage of their own research with Hispanic immigrants to the United States. Adapted from the source document. JF - Ethics & Behavior AU - Eggerth, Donald E AU - Flynn, Michael A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Consortium for Multicultural Psychology Research, Michigan State University Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 229 EP - 242 PB - Taylor & Francis, Philadelphia PA VL - 20 IS - 3-4 SN - 1050-8422, 1050-8422 KW - Colonialism KW - Ethics KW - Hispanic people KW - Immigrants KW - Traditions KW - Federal agencies KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742725235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethics+%26+Behavior&rft.atitle=When+the+Third+World+Comes+to+the+First%3A+Ethical+Considerations+When+Working+With+Hispanic+Immigrants&rft.au=Eggerth%2C+Donald+E%3BFlynn%2C+Michael+A&rft.aulast=Eggerth&rft.aufirst=Donald&rft.date=2010-05-01&rft.volume=20&rft.issue=3-4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Ethics+%26+Behavior&rft.issn=10508422&rft_id=info:doi/10.1080%2F10508421003798968 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Ethics; Hispanic people; Immigrants; Colonialism; Traditions; Federal agencies DO - http://dx.doi.org/10.1080/10508421003798968 ER - TY - JOUR T1 - Health expenditure estimation and functional form: applications of the generalized gamma and extended estimating equations models AN - 742714176; 201016475 AB - Health-care expenditure regressions are used in a wide variety of economic analyses including risk adjustment and program and treatment evaluations. Recent articles demonstrated that generalized gamma models (GGMs) and extended estimating equations (EEE) models provide flexible approaches to deal with a variety of data problems encountered in expenditure estimation. To date there have been few empirical applications of these models to expenditures. We use data from the US Medical Expenditure Panel Survey to compare the bias, predictive accuracy, and marginal effects of GGM and EEE models with other commonly used regression models in a cross-validation study design. Health-care expenditure distributions vary in the degree of heteroskedasticity, skewness, and kurtosis by type of service and population. To examine the ability of estimators to address a range of data problems, we estimate models of total health expenditures and prescription drug expenditures for two populations, the elderly and privately insured adults. Our findings illustrate the need for researchers to examine their assumptions about link functions: the appropriate link function varies across our four distributions. The EEE model, which has a flexible link function, is a robust estimator that performs as well, or better, than the other models in each distribution. Published in 2009 by John Wiley & Sons, Ltd. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Hill, Steven C AU - Miller, G Edward AD - Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, Rockville, MD, USA shill@ahrq.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 608 EP - 627 PB - John Wiley, Chichester UK VL - 19 IS - 5 SN - 1057-9230, 1057-9230 KW - Sons KW - Estimators KW - Health costs KW - Expenditure KW - Risk adjustment KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742714176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Health+expenditure+estimation+and+functional+form%3A+applications+of+the+generalized+gamma+and+extended+estimating+equations+models&rft.au=Hill%2C+Steven+C%3BMiller%2C+G+Edward&rft.aulast=Hill&rft.aufirst=Steven&rft.date=2010-05-01&rft.volume=19&rft.issue=5&rft.spage=608&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1498 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Expenditure; Health costs; Estimators; Health; Risk adjustment; Sons DO - http://dx.doi.org/10.1002/hec.1498 ER - TY - JOUR T1 - Receptor tyrosine kinases and their hormonal regulation in uterine leiomyoma. AN - 733909713; 20414848 AB - Uterine leiomyomas (fibroids, myomas) are benign tumors that develop from smooth muscle cells. Although the most common gynecologic tumor in premenopausal women, there is still little known of the etiology, the genetics and basic/molecular biology, or the influence of the environment on the development and growth of these tumors. The fact that fibroids occur during the reproductive years and regress after menopause indicates a growth dependent on ovarian hormones. Studies have supported a role of estrogen and progesterone in leiomyoma growth possibly through regulating growth factors and their signaling pathways. Activation of steroid hormone receptors can have a myriad of effects and include upregulation of growth factors and receptor tyrosine kinases (RTKs), which through downstream effector proteins such as mitogen-activated protein kinase p44/42, can mediate transcription, translation, and cell proliferation. Due to their hormonal dependency, fibroids may also be targeted by environmental chemicals whose biological effects are mediated through the estrogen and/or progesterone receptors. This review focuses on the role of growth factors and their receptors (RTKs) in uterine leiomyoma growth and their regulation by ovarian hormones. It also presents data on specific signaling pathways activated in uterine leiomyomas and the "cross talk" between the estrogen receptor alpha and RTK signaling pathways. Published in 2010 by Thieme Medical Publishers. JF - Seminars in reproductive medicine AU - Yu, Linda AU - Moore, Alicia B AU - Dixon, Darlene AD - Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 250 EP - 259 VL - 28 IS - 3 KW - Estrogen Receptor alpha KW - 0 KW - Estrogens KW - Hormones KW - Progesterone KW - 4G7DS2Q64Y KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Receptor, IGF Type 1 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Estrogens -- metabolism KW - Progesterone -- metabolism KW - Mitogen-Activated Protein Kinases -- metabolism KW - Receptor, IGF Type 1 -- metabolism KW - Receptor Cross-Talk KW - Humans KW - Estrogen Receptor alpha -- metabolism KW - Signal Transduction KW - Female KW - Leiomyoma -- metabolism KW - Hormones -- metabolism KW - Uterine Neoplasms -- metabolism KW - Receptor Protein-Tyrosine Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733909713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+reproductive+medicine&rft.atitle=Receptor+tyrosine+kinases+and+their+hormonal+regulation+in+uterine+leiomyoma.&rft.au=Yu%2C+Linda%3BMoore%2C+Alicia+B%3BDixon%2C+Darlene&rft.aulast=Yu&rft.aufirst=Linda&rft.date=2010-05-01&rft.volume=28&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Seminars+in+reproductive+medicine&rft.issn=1526-4564&rft_id=info:doi/10.1055%2Fs-0030-1251482 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Oct;108 Suppl 5:795-802 [11035985] Biol Reprod. 2010 Feb;82(2):341-51 [19741209] Gynecol Endocrinol. 2008 Oct;24(10):549-54 [19012097] Virchows Arch. 2008 Dec;453(6):557-69 [18853184] Hum Reprod. 2008 Aug;23(8):1873-83 [18492705] Mol Med. 2008 May-Jun;14(5-6):264-75 [18231572] J Clin Endocrinol Metab. 2007 Oct;92(10):3949-57 [17635941] Oncogene. 2007 May 14;26(22):3113-21 [17496910] Environ Health Perspect. 2000 Oct;108 Suppl 5:829-34 [11035990] J Cell Physiol. 2001 Mar;186(3):414-24 [11169981] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Cell Mol Life Sci. 2002 Jan;59(1):83-96 [11846036] Fertil Steril. 2002 Jul;78(1):1-12 [12095482] Virchows Arch. 2002 Jul;441(1):53-62 [12111201] Nat Rev Cancer. 2002 Oct;2(10):795-803 [12360282] Steroids. 2003 Jan;68(1):1-9 [12475718] Environ Health Perspect. 2003 Jun;111(8):1037-54 [12826476] Trends Neurosci. 2003 Jul;26(7):335-7 [12850425] Mol Hum Reprod. 2003 Nov;9(11):701-7 [14561812] Mol Cell Endocrinol. 2003 Nov 14;209(1-2):9-16 [14604812] Hum Reprod. 2004 Apr;19(4):815-21 [15033949] Crit Rev Oncol Hematol. 2004 Apr;50(1):23-38 [15094157] Semin Reprod Med. 2004 May;22(2):105-11 [15164305] Trends Mol Med. 2004 Jul;10(7):351-7 [15242684] Angiogenesis. 2004;7(1):17-28 [15302992] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] Fertil Steril. 1981 Oct;36(4):433-45 [7026295] Endocr Rev. 1990 Aug;11(3):443-53 [2226350] Nihon Rinsho. 1992 Aug;50(8):1861-6 [1433977] Lancet. 1993 Nov 13;342(8881):1209-10 [7901532] Hum Reprod. 1993 Nov;8(11):1796-806 [7507128] Int J Cancer. 1994 Nov 1;59(3):427-34 [7927953] Biol Reprod. 1995 Sep;53(3):636-46 [7578688] Science. 1995 Dec 1;270(5241):1491-4 [7491495] Exp Hematol. 1996 Feb;24(2):318-23 [8641360] EMBO J. 1996 May 1;15(9):2174-83 [8641283] J Clin Endocrinol Metab. 1996 May;81(5):1967-74 [8626866] Carcinogenesis. 1996 Feb;17(2):271-5 [8625449] Br J Cancer. 1997;75(11):1631-40 [9184179] J Clin Endocrinol Metab. 1998 Jun;83(6):2192-8 [9626159] Mol Hum Reprod. 2005 Jun;11(6):441-50 [15879465] Mol Endocrinol. 2005 Aug;19(8):1951-9 [15705661] Eur J Obstet Gynecol Reprod Biol. 2005 Nov 1;123(1):107-10 [16260343] Biochimie. 2006 Feb;88(2):141-6 [16139411] Cancer Biol Ther. 2006 Jan;5(1):28-33 [16294022] Biochemistry. 2006 May 23;45(20):6241-51 [16700535] Hum Reprod. 2006 Jul;21(7):1869-77 [16613890] Cell. 2006 Oct 6;127(1):45-8 [17018275] Fertil Steril. 2007 Jan;87(1):127-35 [17074332] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1055/s-0030-1251482 ER - TY - JOUR T1 - ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue. AN - 733859763; 20307197 AB - K-RAS mutation is being developed as a cancer biomarker and tumor K-RAS is being used to predict therapeutic response. Yet, levels of K-RAS mutation in normal and pathological tissue samples have not been determined rigorously, nor inter-individual variation in these levels characterized. Therefore, K-RAS codon 12 GAT and GTT mutant fractions were measured in colonic mucosa of individuals without colon cancer, tumor-distal mucosa, tumor-proximal mucosa, normal tumor-adjacent tissues, colonic adenomas, and carcinomas. The results indicate K-RAS codon 12 GAT mutation is present at measurable levels in normal appearing mucosa. All tumors carried K-RAS mutation, in most cases as a mutant subpopulation. JF - Cancer investigation AU - Parsons, Barbara L AU - Marchant-Miros, Kathryn E AU - Delongchamp, Robert R AU - Verkler, Tracie L AU - Patterson, Tucker A AU - McKinzie, Page B AU - Kim, Lawrence T AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, 3900 NCTR Road, Jefferson, AR 72079, USA. barbara.parsons@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 364 EP - 375 VL - 28 IS - 4 KW - Codon KW - 0 KW - KRAS protein, human KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - ras Proteins KW - Index Medicus KW - Humans KW - Male KW - ras Proteins -- genetics KW - Colonic Neoplasms -- genetics KW - Polymerase Chain Reaction -- methods KW - Proto-Oncogene Proteins -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733859763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=ACB-PCR+quantification+of+K-RAS+codon+12+GAT+and+GTT+mutant+fraction+in+colon+tumor+and+non-tumor+tissue.&rft.au=Parsons%2C+Barbara+L%3BMarchant-Miros%2C+Kathryn+E%3BDelongchamp%2C+Robert+R%3BVerkler%2C+Tracie+L%3BPatterson%2C+Tucker+A%3BMcKinzie%2C+Page+B%3BKim%2C+Lawrence+T&rft.aulast=Parsons&rft.aufirst=Barbara&rft.date=2010-05-01&rft.volume=28&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=1532-4192&rft_id=info:doi/10.3109%2F07357901003630975 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-21 N1 - Date created - 2010-04-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/07357901003630975 ER - TY - JOUR T1 - Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in rats. AN - 733578072; 20117204 AB - At high levels of exposure, acrylamide monomer (AA) is a known neurotoxicant (LoPachin, 2004 [23]). The effects of lower levels of exposure, such as those experienced via a typical human diet, have not been widely investigated. Data at these levels are particularly relevant given the widespread human exposure through carbohydrate-containing foods cooked at high temperatures. Additionally, daily AA intake is estimated to be higher for infants and children. Earlier, we described behavioral alterations in preweaning rats resulting from developmental AA treatment (0.5-10.0mg/kg/day) (Garey et al., 2005 [14]). In the present study, the effects of lower doses were measured as well as serum AA and glycidimide (GA) levels in dams, fetuses, and young pups. Pregnant Fischer 344 dams (n=48-58/treatment group) were gavaged with 0.0, 0.1, 0.3, 1.0, or 5.0mg AA/kg/day beginning on gestational day 6 and ending on the day of parturition. Beginning on postnatal day 1 (PND 1) and continuing through PND 21, all pups/litter were gavaged with the same dose as their dam. There were no AA treatment effects on offspring fur development, pinnae detachment, or eye opening. Offspring body weight was somewhat decreased by 5.0mg/kg/day, particularly in males. However, righting reflex (PNDs 4-7), slant board (i.e., negative geotaxis) (PNDs 8-10), forelimb hang (PNDs 12-16), and rotarod behavior (PNDs 21-22) were not significantly altered by AA treatment. Male and female offspring of the 5.0mg/kg/day group were 30-49% less active in the open field at PNDs 19-20 (p<0.05). Serum AA levels of GD20 dams and their fetuses were comparable, indicating the ability of AA to cross the placental barrier. AA levels of pups were not affected by age (PND 1 and 22) or sex. In all rats, serum AA and GA levels exhibited a dose-response relationship. These data extend those of our previous study (Garey et al., 2005 [14]) and demonstrate that overt preweaning neurobehavioral effects are apparent in rats exposed to acrylamide pre- and postnatally, but only at the highest doses tested. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Garey, Joan AU - Smith, Melody E AU - Twaddle, Nathan C AU - Doerge, Daniel R AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, United States. Sherry.Ferguson@fda.hhs.gov PY - 2010 SP - 373 EP - 382 VL - 32 IS - 3 KW - Epoxy Compounds KW - 0 KW - Acrylamide KW - 20R035KLCI KW - glycidamide KW - 6G5ELX5XYN KW - Index Medicus KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Ear Auricle -- growth & development KW - Weaning KW - Pregnancy KW - Rats KW - Hair -- drug effects KW - Animals, Newborn KW - Ear Auricle -- drug effects KW - Rats, Inbred F344 KW - Hair -- growth & development KW - Reflex -- drug effects KW - Rotarod Performance Test KW - Body Weight -- drug effects KW - Chromatography, Liquid KW - Motor Activity -- drug effects KW - Female KW - Male KW - Behavior, Animal -- drug effects KW - Epoxy Compounds -- blood KW - Prenatal Exposure Delayed Effects -- psychology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Prenatal Exposure Delayed Effects -- blood KW - Acrylamide -- blood KW - Acrylamide -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733578072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Preweaning+behaviors%2C+developmental+landmarks%2C+and+acrylamide+and+glycidamide+levels+after+pre-+and+postnatal+acrylamide+treatment+in+rats.&rft.au=Ferguson%2C+Sherry+A%3BGarey%2C+Joan%3BSmith%2C+Melody+E%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel+R%3BPaule%2C+Merle+G&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2010-05-01&rft.volume=32&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2010.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-02 N1 - Date created - 2010-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2010.01.010 ER - TY - JOUR T1 - Detection and characterization of virulence genes and integrons in Aeromonas veronii isolated from catfish. AN - 733536882; 20227596 AB - The presence of virulence genes and integrons was determined in 81 strains of Aeromonas veronii isolated from farm-raised catfish. Polymerase chain reaction (PCR) protocols were used to determine the presence of genes for cytotoxic enterotoxin (act), aerolysin (aerA), two cytotonic enterotoxins (ast, alt), lipase (lip), glycerophospholipid:cholesterol acyltransferase (gcaT), serine protease (ser), DNases (exu), elastase (ahyB) and the structural gene flagellin (fla) in the template DNA. Oligonucleotide primers amplified a 231-bp region of the act gene from the template DNA of 97.0% of the isolates. Primers specific for the amplification of the aerA gene amplified a 431-bp region of the aerA gene from the template DNA of 96.0% of the isolates. None of the isolates contained ast or alt genes. Oligonucleotide primers specific for the amplification of lip, gcaT, ser and fla genes, amplified their respective amplicons from 85.0, 78.0, 82.0 and 80.0% of the isolates. None of the isolates contained exu or the elastase genes. Several of the isolates (48.0%) contained class I integrons that confer resistance to multiple antibiotics; various sizes between 0.6 and 3.1 kb were found. None of the isolates contained Class II integrons. Our results indicate that farm-raised catfish may be a source of pathogenic A. veronii and that the potential health risks posed by virulent strains of A. veronii should not be underestimated. Published by Elsevier Ltd. JF - Food microbiology AU - Nawaz, Mohamed AU - Khan, Saeed A AU - Khan, Ashraf A AU - Sung, Kidon AU - Tran, Quynhtien AU - Kerdahi, Khalil AU - Steele, Roger AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Mohamed.nawaz@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 327 EP - 331 VL - 27 IS - 3 KW - DNA, Bacterial KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - Food Microbiology KW - Consumer Product Safety KW - Virulence -- genetics KW - Humans KW - Gram-Negative Bacterial Infections -- microbiology KW - DNA, Bacterial -- analysis KW - Gene Amplification KW - Aeromonas -- pathogenicity KW - Aeromonas -- isolation & purification KW - Catfishes -- microbiology KW - Food Contamination -- analysis KW - Seafood -- microbiology KW - Aeromonas -- genetics KW - Integrons -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733536882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Detection+and+characterization+of+virulence+genes+and+integrons+in+Aeromonas+veronii+isolated+from+catfish.&rft.au=Nawaz%2C+Mohamed%3BKhan%2C+Saeed+A%3BKhan%2C+Ashraf+A%3BSung%2C+Kidon%3BTran%2C+Quynhtien%3BKerdahi%2C+Khalil%3BSteele%2C+Roger&rft.aulast=Nawaz&rft.aufirst=Mohamed&rft.date=2010-05-01&rft.volume=27&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=1095-9998&rft_id=info:doi/10.1016%2Fj.fm.2009.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-19 N1 - Date created - 2010-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fm.2009.11.007 ER - TY - JOUR T1 - Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes. AN - 733519378; 20053928 AB - Estrogen plays a major role in endometrial carcinogenesis, suggesting that common variants of genes in the sex hormone metabolic pathway may be related to endometrial cancer risk. In support of this view, variants in CYP19A1 [cytochrome P450 (CYP), family 19, subfamily A, polypeptide 1] have been associated with both circulating estrogen levels and endometrial cancer risk. Associations with variants in other genes have been suggested, but findings have been inconsistent. We examined 36 sex hormone-related genes using a tagging approach in a population-based case-control study of 417 endometrial cancer cases and 407 controls conducted in Poland. We evaluated common variation in these genes in relation to endometrial cancer risk using sequential haplotype scan, variable-sized sliding window and adaptive rank-truncated product (ARTP) methods. In our case-control study, the strongest association with endometrial cancer risk was for AR (androgen receptor; ARTP P = 0.006). Multilocus analyses also identified boundaries for a region of interest in AR and in CYP19A1 around a previously identified susceptibility loci. We did not find evidence for consistent associations between previously reported candidate single-nucleotide polymorphisms in this pathway and endometrial cancer risk. In summary, we identified regions in AR and CYP19A1 that are of interest for further evaluation in relation to endometrial cancer risk in future haplotype and subsequent fine mapping studies in larger study populations. JF - Carcinogenesis AU - Yang, Hannah P AU - Gonzalez Bosquet, Jesus AU - Li, Qizhai AU - Platz, Elizabeth A AU - Brinton, Louise A AU - Sherman, Mark E AU - Lacey, James V AU - Gaudet, Mia M AU - Burdette, Laurie A AU - Figueroa, Jonine D AU - Ciampa, Julia G AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Chanock, Stephen J AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA. yanghan@mail.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 827 EP - 833 VL - 31 IS - 5 KW - AR protein, human KW - 0 KW - Estrogens KW - Receptors, Androgen KW - Aromatase KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Index Medicus KW - Risk KW - Genetic Variation KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Female KW - Polymorphism, Single Nucleotide KW - Cytochrome P-450 CYP1A1 -- genetics KW - Estrogens -- metabolism KW - Receptors, Androgen -- genetics KW - Aromatase -- genetics KW - Endometrial Neoplasms -- genetics KW - Endometrial Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733519378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Common+genetic+variation+in+the+sex+hormone+metabolic+pathway+and+endometrial+cancer+risk%3A+pathway-based+evaluation+of+candidate+genes.&rft.au=Yang%2C+Hannah+P%3BGonzalez+Bosquet%2C+Jesus%3BLi%2C+Qizhai%3BPlatz%2C+Elizabeth+A%3BBrinton%2C+Louise+A%3BSherman%2C+Mark+E%3BLacey%2C+James+V%3BGaudet%2C+Mia+M%3BBurdette%2C+Laurie+A%3BFigueroa%2C+Jonine+D%3BCiampa%2C+Julia+G%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BChanock%2C+Stephen+J%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Hannah&rft.date=2010-05-01&rft.volume=31&rft.issue=5&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp328 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-14 N1 - Date created - 2010-05-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1415-6 [16835347] J Natl Cancer Inst. 2006 Sep 20;98(18):1311-20 [16985250] Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2570-3 [17164389] J Exp Clin Cancer Res. 2006 Sep;25(3):411-6 [17167982] Am J Epidemiol. 2007 Feb 1;165(3):235-45 [17110639] Curr Protoc Bioinformatics. 2005 Oct;Chapter 1:Unit 1.12 [18428742] Cancer. 2008 May 1;112(9):1964-73 [18318428] Endocr Dev. 2008;13:1-18 [18493130] Endocr Relat Cancer. 2008 Jun;15(2):451-63 [18508998] Endocr Relat Cancer. 2008 Jun;15(2):485-97 [18509001] Carcinogenesis. 2000 Apr;21(4):623-7 [10753195] Nat Genet. 2000 May;25(1):25-9 [10802651] Cancer Res. 2001 Feb 1;61(3):848-9 [11221867] Cancer Res. 2001 May 15;61(10):3955-60 [11358812] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Int J Cancer. 2002 Jun 10;99(5):652-7 [12115497] Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12263-8 [12218173] Biochem Biophys Res Commun. 2002 Sep 27;297(3):558-64 [12270131] Cancer Res. 2003 Jul 15;63(14):3913-8 [12873984] Obstet Gynecol. 2003 Sep;102(3):506-11 [12962933] Int J Cancer. 2004 Jan 20;108(3):425-32 [14648710] Int J Gynecol Cancer. 2003 Nov-Dec;13(6):785-90 [14675315] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Cancer Res. 2004 Feb 1;64(3):1202-7 [14871858] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):213-9 [14973105] Carcinogenesis. 2004 Apr;25(4):559-65 [14656940] Cancer Lett. 2004 Apr 30;207(2):191-6 [15072828] J Natl Cancer Inst. 2004 Jun 16;96(12):936-45 [15199113] Int J Gynecol Cancer. 2007 Jan-Feb;17(1):229-32 [17291258] Pharmacogenet Genomics. 2007 Feb;17(2):161-7 [17301695] Cancer Res. 2007 Mar 1;67(5):1893-7 [17325027] Am J Hum Genet. 2007 Apr;80(4):705-15 [17357076] Cancer. 2007 Apr 1;109(7):1296-302 [17315164] Br J Cancer. 2007 May 7;96(9):1450-6 [17426703] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):943-9 [17507620] Genet Epidemiol. 2007 Sep;31(6):553-64 [17487883] Cancer Causes Control. 2007 Dec;18(10):1123-30 [17717632] Carcinogenesis. 2007 Oct;28(10):2139-42 [17434921] Hum Genet. 2008 Mar;123(2):155-62 [18172694] Cancer Causes Control. 2004 Aug;15(6):627-33 [15280642] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1515-20 [15342454] Adv Exp Med Biol. 2008;630:148-65 [18637490] Mol Carcinog. 2008 Oct;47(10):768-74 [18324659] Cancer Causes Control. 2008 Nov;19(9):955-63 [18437511] Nutr Cancer. 2008;60(6):736-43 [19005973] BMC Cancer. 2008;8:322 [18990228] Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):242-7 [19124504] Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):585-9 [19190146] Pharmacogenet Genomics. 2009 Mar;19(3):239-43 [19352303] Cancer. 2009 Jun 15;115(12):2693-700 [19382201] BJOG. 2009 Jul;116(8):1053-61 [19438492] Genet Epidemiol. 2009 Dec;33(8):700-9 [19333968] Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):563-70 [18349273] Am J Pathol. 1995 Feb;146(2):491-500 [7856758] J Natl Cancer Inst. 1996 Aug 21;88(16):1127-35 [8757192] Br J Cancer. 1997;75(9):1385-8 [9155064] Carcinogenesis. 1997 Dec;18(12):2307-11 [9450474] Endocr Rev. 2004 Dec;25(6):947-70 [15583024] Eur J Obstet Gynecol Reprod Biol. 2005 Feb 1;118(2):246-50 [15653213] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):357-66 [15734958] Int J Cancer. 2005 Aug 20;116(2):267-74 [15800924] Int J Cancer. 2006 Mar 1;118(5):1261-8 [16161040] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D322-6 [16381878] Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:448-51 [16515644] Am J Hum Genet. 2006 Apr;78(4):629-44 [16532393] Pharmacogenomics J. 2006 May-Jun;6(3):189-93 [16402077] Pol J Pathol. 2006;57(1):35-40 [16739881] Best Pract Res Clin Endocrinol Metab. 2006 Jun;20(2):235-44 [16772154] Int J Gynecol Cancer. 2006 May-Jun;16(3):1407-11 [16803538] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp328 ER - TY - JOUR T1 - Bacterial and viral pathogens in live oysters: 2007 United States market survey. AN - 733308390; 20190085 AB - Two samples of market oysters, primarily from retail establishments, were collected twice each month in each of nine states during 2007. Samples were shipped refrigerated overnight to five U.S. Food and Drug Administration laboratories on a rotating basis and analyzed by most probable number (MPN) for total and pathogenic Vibrio parahaemolyticus and V. vulnificus numbers and for the presence of toxigenic V. cholerae, Salmonella spp., norovirus (NoV), and hepatitis A virus (HAV). Levels of indicator organisms, including fecal coliforms (MPN), Escherichia coli (MPN), male-specific bacteriophage, and aerobic plate counts, were also determined. V. parahaemolyticus and V. vulnificus levels were distributed seasonally and geographically by harvest region and were similar to levels observed in a previous study conducted in 1998-1999. Levels of pathogenic V. parahaemolyticus were typically several logs lower than total V. parahaemolyticus levels regardless of season or region. Pathogenic V. parahaemolyticus levels in the Gulf and Mid-Atlantic regions were about two logs greater than the levels observed in the Pacific and North Atlantic regions. Pathogens generally associated with fecal pollution were detected sporadically or not at all (toxigenic V. cholerae, 0%; Salmonella, 1.5%; NoV, 3.9%; HAV, 4.4%). While seasonal prevalences of NoV and HAV were generally greater in oysters harvested from December to March, the low detection frequency obscured any apparent seasonal effects. Overall, there was no relationship between the levels of indicator microorganisms and the presence of enteric viruses. These data provide a baseline that can be used to further validate risk assessment predictions, determine the effectiveness of new control measures, and compare the level of protection provided by the U.S. shellfish sanitation system to those in other countries. JF - Applied and environmental microbiology AU - DePaola, Angelo AU - Jones, Jessica L AU - Woods, Jacquelina AU - Burkhardt, William AU - Calci, Kevin R AU - Krantz, Jeffrey A AU - Bowers, John C AU - Kasturi, Kuppuswamy AU - Byars, Robin H AU - Jacobs, Emily AU - Williams-Hill, Donna AU - Nabe, Khamphet AD - U.S. Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama 36528-0158, USA. angelo.depaola@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 2754 EP - 2768 VL - 76 IS - 9 KW - Index Medicus KW - Caliciviridae Infections -- virology KW - Animals KW - Caliciviridae Infections -- epidemiology KW - Norovirus -- isolation & purification KW - Humans KW - Seasons KW - Mid-Atlantic Region KW - Disease Outbreaks KW - United States -- epidemiology KW - Vibrio vulnificus -- isolation & purification KW - Vibrio parahaemolyticus -- isolation & purification KW - Ostreidae -- virology KW - Viruses -- isolation & purification KW - Ostreidae -- microbiology KW - Bacteria -- isolation & purification KW - Shellfish -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733308390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Bacterial+and+viral+pathogens+in+live+oysters%3A+2007+United+States+market+survey.&rft.au=DePaola%2C+Angelo%3BJones%2C+Jessica+L%3BWoods%2C+Jacquelina%3BBurkhardt%2C+William%3BCalci%2C+Kevin+R%3BKrantz%2C+Jeffrey+A%3BBowers%2C+John+C%3BKasturi%2C+Kuppuswamy%3BByars%2C+Robin+H%3BJacobs%2C+Emily%3BWilliams-Hill%2C+Donna%3BNabe%2C+Khamphet&rft.aulast=DePaola&rft.aufirst=Angelo&rft.date=2010-05-01&rft.volume=76&rft.issue=9&rft.spage=2754&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.02590-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-23 N1 - Date created - 2010-04-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol Methods. 2001 May;94(1-2):25-35 [11337037] J Clin Virol. 2009 Jan;44(1):1-8 [19084472] J Food Prot. 2002 Jan;65(1):79-87 [11808810] Appl Environ Microbiol. 2002 Apr;68(4):1925-31 [11916714] Int J Food Microbiol. 2002 Mar 25;74(1-2):119-30 [11929166] J Food Prot. 2002 Jun;65(6):970-4 [12092730] Appl Environ Microbiol. 2002 Aug;68(8):3702-7 [12147462] Clin Infect Dis. 2002 Sep 15;35(6):748-53 [12203173] Appl Environ Microbiol. 2002 Dec;68(12):5990-8 [12450820] J Food Prot. 2002 Dec;65(12):1873-80 [12495004] J Clin Microbiol. 2000 Feb;38(2):578-85 [10655349] Appl Environ Microbiol. 2000 Apr;66(4):1280-5 [10742200] Appl Environ Microbiol. 2000 Apr;66(4):1375-8 [10742214] J Infect Dis. 2000 May;181 Suppl 2:S360-6 [10804149] J Infect Dis. 2000 May;181(5):1661-6 [10823766] Appl Environ Microbiol. 2000 Aug;66(8):3241-8 [10919776] JAMA. 2000 Sep 27;284(12):1541-5 [11000648] J Clin Microbiol. 2003 Jan;41(1):442-6 [12517889] Appl Environ Microbiol. 2003 Mar;69(3):1521-6 [12620838] Appl Environ Microbiol. 2003 Mar;69(3):1556-63 [12620843] J Microbiol Methods. 2003 May;53(2):149-55 [12654486] Appl Environ Microbiol. 2003 Apr;69(4):2292-7 [12676712] J Clin Microbiol. 2003 Apr;41(4):1548-57 [12682144] J Clin Microbiol. 2003 Jun;41(6):2417-27 [12791858] Appl Environ Microbiol. 2003 Dec;69(12):7130-6 [14660358] Appl Environ Microbiol. 2004 May;70(5):2678-84 [15128518] J Infect Dis. 1974 Jun;129(6):709-14 [4209723] Appl Microbiol. 1975 Aug;30(2):251-7 [1164012] N Engl J Med. 1979 Jan 4;300(1):1-5 [758155] Appl Environ Microbiol. 1979 Jan;37(1):91-103 [367273] N Engl J Med. 1980 Feb 7;302(6):305-9 [7350497] Appl Environ Microbiol. 1982 Dec;44(6):1404-14 [7159083] Appl Environ Microbiol. 1983 Jan;45(1):122-6 [6337547] Appl Environ Microbiol. 1990 Apr;56(4):904-7 [2339878] Appl Environ Microbiol. 1990 Aug;56(8):2299-302 [2403249] Appl Environ Microbiol. 1991 May;57(5):1301-5 [1830197] Appl Environ Microbiol. 1994 Sep;60(9):3483-4 [7944379] Clin Microbiol Rev. 1994 Oct;7(4):419-25 [7834599] Int J Food Microbiol. 1997 Sep 16;38(2-3):133-42 [9506279] Appl Environ Microbiol. 1998 Apr;64(4):1459-65 [9546182] MMWR Morb Mortal Wkly Rep. 1998 Jun 12;47(22):457-62 [9639367] J Infect Dis. 1998 Sep;178(3):752-9 [9728544] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] Appl Environ Microbiol. 2005 Feb;71(2):893-7 [15691945] N Engl J Med. 2005 Oct 6;353(14):1463-70 [16207848] Appl Environ Microbiol. 2006 Mar;72(3):1800-9 [16517625] Int J Food Microbiol. 2006 May 1;108(3):391-6 [16499983] MMWR Morb Mortal Wkly Rep. 2006 Aug 11;55(31):854-6 [16902397] Water Environ Res. 2006 Aug;78(8):828-34 [17059136] J Microbiol Methods. 2007 Feb;68(2):254-9 [17034889] J Food Prot. 2007 Jan;70(1):145-50 [17265873] Microbiol Immunol. 2007;51(2):177-84 [17310085] Appl Environ Microbiol. 2007 Sep;73(18):5840-7 [17644647] Int J Food Microbiol. 2008 Mar 20;122(3):279-86 [18279989] J Bacteriol. 2008 Apr;190(8):2831-40 [18281404] J Food Prot. 2008 Jul;71(7):1427-33 [18680943] Emerg Infect Dis. 2008 Oct;14(10):1553-7 [18826818] Res Microbiol. 2001 Oct;152(8):743-51 [11686388] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.02590-09 ER - TY - JOUR T1 - Modifying a displacement pump for oral gavage dosing of solution and suspension preparations to adult and neonatal mice. AN - 733104387; 20410899 AB - To assess a drug's toxic or carcinogenic effects on neonatal and adult mice and rats, researchers often carry out oral gavage studies. Whether dosed singly or in various combinations, provided as soluble solutions or as colloidal suspensions, the drug must be delivered in accurate and precise doses. For studies that require newborn mice to receive multiple daily doses, delicately handling neonates to increase their chances of surviving is just as critical as the ability to accurately dose small volumes. To help ensure accurate and precise delivery of drug doses ranging from 5 microl for neonatal mice to 400 microl for adults, the authors adapted an automated pipetting system. By slightly modifying standard gavage needles, the authors delivered, on average, 98-99% of targeted dose volumes to neonatal mice. JF - Lab animal AU - Lewis, Sherry M AU - Lee, Fei W AU - Ali, A Afshan AU - Allaben, William T AU - Weis, Constance C AU - Leakey, Julian E A AD - Office of Scientific Coordination, National Center for Toxicological Research, Jefferson, AR, USA. sherrym.lewis@fda.hhs.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 149 EP - 154 VL - 39 IS - 5 SN - 0093-7355, 0093-7355 KW - Drug Combinations KW - 0 KW - Solutions KW - Suspensions KW - Xenobiotics KW - Index Medicus KW - Administration, Oral KW - Animals KW - Mice KW - Mice, Knockout KW - Pregnancy KW - Animals, Newborn KW - Mice, Inbred C3H KW - Toxicity Tests -- methods KW - Female KW - Male KW - Infusion Pumps KW - Xenobiotics -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733104387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lab+animal&rft.atitle=Modifying+a+displacement+pump+for+oral+gavage+dosing+of+solution+and+suspension+preparations+to+adult+and+neonatal+mice.&rft.au=Lewis%2C+Sherry+M%3BLee%2C+Fei+W%3BAli%2C+A+Afshan%3BAllaben%2C+William+T%3BWeis%2C+Constance+C%3BLeakey%2C+Julian+E+A&rft.aulast=Lewis&rft.aufirst=Sherry&rft.date=2010-05-01&rft.volume=39&rft.issue=5&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Lab+animal&rft.issn=00937355&rft_id=info:doi/10.1038%2Flaban0510-149 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-15 N1 - Date created - 2010-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1038/laban0510-149 ER - TY - JOUR T1 - Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation AN - 1033018651 AB - The present work is concerned to model the molecular signalling pathway for vasodilation and to predict the resting young human forearm blood flow under heat stress. The mechanistic electronic modelling technique has been designed and implemented using MULTISIM 8.0 and an assumption of 1V/°C for prediction of forearm blood flow and the digital logic has been used to design the molecular signalling pathway for vasodilation. The minimum forearm blood flow has been observed at 35°C (0ml100ml -1 min-1 ) and the maximum at 42°C (18.7ml100ml-1 min-1 ) environmental temperature with respect to the base value of 2ml100ml-1 min-1 . This model may also enable to identify many therapeutic targets that can be used in the treatment of inflammations and disorders due to heat-related illnesses. JF - Computers in Biology and Medicine AU - Aggarwal, Yogender AU - Karan, Bhuwan Mohan AU - Das, Barda Nand AU - Sinha, Rakesh Kumar Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 533 EP - 542 CY - Oxford PB - Elsevier Limited VL - 40 IS - 5 SN - 00104825 KW - Medical Sciences--Computer Applications KW - Carbon monoxide KW - Environmental temperature KW - Heme oxygenase-1 KW - Mechanistic electronic model KW - Signalling pathway modelling KW - BV KW - biliverdin KW - BVR KW - biliverdin reductase KW - Ca++ KW - calcium KW - CO KW - carbon monoxide KW - HSF KW - heat shock factor KW - HSP KW - heat shock protein KW - HO-1 KW - heme oxygenase-1 KW - cGMP KW - guanosine 3[variant prime],5[variant prime]-cyclic monophosphate KW - sGC KW - soluble guanylyl cyclase KW - ERK KW - extra-cellular signal-regulated kinases KW - JNK KW - c-Jun N-terminal protein kinase KW - KCa KW - calcium-activated potassium channels KW - NO KW - nitrogen oxide KW - p38 MAPK KW - p38 mitogen-activated protein kinase KW - Tsk KW - Skin Temperature KW - FBF KW - forearm blood flow KW - T re KW - body core KW - T sk KW - body surface KW - SkBF KW - skin blood flow KW - TNZ KW - thermoneutal zone KW - V2 KW - input heat stress KW - TNF-α KW - tumor necrosis factor-α KW - IL KW - interleukins KW - PO/AH KW - anterior hypothalamus Preoptic area KW - IRP KW - Iron regulatory protein KW - Heatstroke KW - Proteins KW - Heat KW - Biology KW - Signal transduction KW - Genetic engineering KW - Ordinary differential equations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1033018651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Biology+and+Medicine&rft.atitle=Mechanistic+electronic+model+to+simulate+and+predict+the+effect+of+heat+stress+on+the+functional+genomics+of+HO-1+system%3A+Vasodilation&rft.au=Aggarwal%2C+Yogender%3BKaran%2C+Bhuwan+Mohan%3BDas%2C+Barda+Nand%3BSinha%2C+Rakesh+Kumar&rft.aulast=Aggarwal&rft.aufirst=Yogender&rft.date=2010-05-01&rft.volume=40&rft.issue=5&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Computers+in+Biology+and+Medicine&rft.issn=00104825&rft_id=info:doi/10.1016%2Fj.compbiomed.2010.03.011 LA - English DB - ProQuest Central N1 - Copyright - © 2010 Elsevier Ltd N1 - Last updated - 2013-10-25 N1 - CODEN - CBMDAW DO - http://dx.doi.org/10.1016/j.compbiomed.2010.03.011 ER - TY - JOUR T1 - Relationship of work injury severity to family member hospitalization AN - 1017965311; 16691679 AB - Background Working while under stress due to a family health event may result in injuries of greater severity. Work leave might mitigate such consequences. Data and Methods Workers' compensation data for 33,817 injured workers and inpatient medical data for 76,077 members of their families were extracted from the 2002-2005 Thomson Reuters Medstat MarketScan Health and Productivity Management (HPM) and Commercial Claims and Encounter (CCE) datasets. Using a probit model, the impact of family hospitalization on the probability that a subsequent injury would be severe (above average indemnity costs) was estimated, adjusting for age, sex, hourly versus salaried status, industry sector, state, and family size. Results Family hospitalization within 15 days before injury increased the likelihood that the injury would be severe (from 12.5% to 21.5%) and was associated with 40% higher indemnity costs and 50% higher medical costs. Hospitalizations over 30 days before injury had no impact. Conclusion The observed higher severity of work injuries following family hospitalizations suggests additional analyses may find higher injury rates as well, and that timely family leaves might help prevent severe workplace injuries. Am. J. Ind. Med. 53:506-513, 2010. ? 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Asfaw, Abay G AU - Bushnell, P Timothy AU - Ray, Tapas K AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Office of the Director, Washington, District of Columbia, hqp0@cdc.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 506 EP - 513 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 5 SN - 1097-0274, 1097-0274 KW - Health & Safety Science Abstracts KW - workers' compensation KW - Age KW - Injuries KW - Stress KW - family size KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017965311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Relationship+of+work+injury+severity+to+family+member+hospitalization&rft.au=Asfaw%2C+Abay+G%3BBushnell%2C+P+Timothy%3BRay%2C+Tapas+K&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2010-05-01&rft.volume=53&rft.issue=5&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20804 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20804/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - workers' compensation; Age; Injuries; Stress; family size DO - http://dx.doi.org/10.1002/ajim.20804 ER - TY - JOUR T1 - Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study AN - 1017963854; 16691677 AB - Background We investigated the potential for selection bias due to non-participation in the follow-up of a large prospective cohort study. Methods Licensed pesticide applicators (52,395 private; 4,916 commercial) in the Agricultural Health Study provided demographic, health, and pesticide exposure information at enrollment (1993-1997) and in a 5-year follow-up telephone interview. Factors associated with non-participation in the follow-up were identified using multiple logistic regression. Potential for selection bias was evaluated by comparing exposure-disease associations between the entire cohort and the follow-up subset. Results Sixty-six percent of private and 60% of commercial applicators completed the follow-up interview. Private and commercial applicators who did not complete the follow-up reported at enrollment younger age, less education, lower body mass index, poorer health behaviors but fewer health conditions, and lower pesticide use. Estimates of exposure-disease associations calculated with and without non-participants did not indicate strong selection bias. Conclusions Differences between non-participants and participants in the follow-up interview were generally small, and we did not find significant evidence of selection bias. However, the extent of bias may depend on the specific exposure and outcome under study. Am. J. Ind. Med. 53:486-496, 2010. ? 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Montgomery, Martha P AU - Kamel, Freya AU - Hoppin, Jane A AU - Freeman, Laura E Beane AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, sandler@niehs.nih.gov Y1 - 2010/05// PY - 2010 DA - May 2010 SP - 486 EP - 496 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 53 IS - 5 SN - 1097-0274, 1097-0274 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - demography KW - Demography KW - Education KW - Age KW - body mass KW - Pesticides KW - Body mass index KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017963854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Effects+of+self-reported+health+conditions+and+pesticide+exposures+on+probability+of+follow-up+in+a+prospective+cohort+study&rft.au=Montgomery%2C+Martha+P%3BKamel%2C+Freya%3BHoppin%2C+Jane+A%3BFreeman%2C+Laura+E+Beane%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Montgomery&rft.aufirst=Martha&rft.date=2010-05-01&rft.volume=53&rft.issue=5&rft.spage=486&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=10970274&rft_id=info:doi/10.1002%2Fajim.20789 L2 - http://onlinelibrary.wiley.com/doi/10.1002/ajim.20789/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2013-11-15 N1 - SubjectsTermNotLitGenreText - Demography; Age; Pesticides; Body mass index; demography; Education; body mass DO - http://dx.doi.org/10.1002/ajim.20789 ER - TY - JOUR T1 - Multiclass, multiresidue method for the detection of antibiotic residues in distillers grains by liquid chromatography and ion trap tandem mass spectrometry AN - 745636013; 13005226 AB - The increased production of ethanol in the US has resulted in large amounts of distillers grains (DG) which is an excellent feed supplement for livestock. However, the use of antimicrobials during ethanol fermentation has led to a growing concern over the possibility of their residues remaining in DG. To enable the detection of antimicrobial residues, a robust LC-MS/MS method was developed that included 13 antibiotics of diverse chemistries, ampicillin, penicillin G, tetracycline, oxytetracycline, chlortetracycline, bacitracin A, virginiamycin M1, chloramphenicol, erythromycin A, clarithromycin, tylosin A, monensin A and streptomycin. The residues were extracted with an aqueous solution of EDTA and trichloroacetic acid followed by methanol. The combined extract was subjected to a two-track cleanup and concentration on either hydrophilic polymeric or weak cation exchange solid phase extraction cartridges. The extracts are analyzed by LC/ion trap tandem mass spectrometry. The method was validated in dry DG matrix. Absolute recoveries of the analytes ranged from 50 to 100%. Accuracy ranged from 89 to 111% based on calibration by processed standards. The limits of detection and relative standard deviation are satisfactory to support future surveillance studies. The method was subsequently tested in three different end-products of DG: distillers dry grains, distillers wet grains and distillers grains solubles. JF - Journal of Chromatography A AU - De Alwis, Hemakanthi AU - Heller, David N AD - Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA, hemakanthi.dealwis@fda.hhs.gov Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 3076 EP - 3084 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 1217 IS - 18 SN - 0021-9673, 0021-9673 KW - Biotechnology and Bioengineering Abstracts KW - Residue analysis KW - Antimicrobials KW - Distillers grain KW - Feed KW - Tandem mass spectrometry KW - Fermentation KW - Methanol KW - Antibiotics KW - Streptomycin KW - Bacitracin KW - Tetracyclines KW - Trichloroacetic acid KW - Oxytetracycline KW - Mass spectroscopy KW - Clarithromycin KW - Ethanol KW - Chloramphenicol KW - monensin KW - Ampicillin KW - Virginiamycin KW - Erythromycin KW - Penicillin KW - Livestock KW - Antimicrobial agents KW - Standard deviation KW - Cations KW - Chlortetracycline KW - Liquid chromatography KW - Grain KW - Tylosin KW - Edetic acid KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745636013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatography+A&rft.atitle=Multiclass%2C+multiresidue+method+for+the+detection+of+antibiotic+residues+in+distillers+grains+by+liquid+chromatography+and+ion+trap+tandem+mass+spectrometry&rft.au=De+Alwis%2C+Hemakanthi%3BHeller%2C+David+N&rft.aulast=De+Alwis&rft.aufirst=Hemakanthi&rft.date=2010-04-30&rft.volume=1217&rft.issue=18&rft.spage=3076&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatography+A&rft.issn=00219673&rft_id=info:doi/10.1016%2Fj.chroma.2010.02.081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fermentation; Methanol; Antibiotics; Bacitracin; Streptomycin; Tetracyclines; Oxytetracycline; Trichloroacetic acid; Mass spectroscopy; Clarithromycin; Ethanol; Chloramphenicol; monensin; Virginiamycin; Ampicillin; Erythromycin; Penicillin; Antimicrobial agents; Livestock; Standard deviation; Cations; Liquid chromatography; Chlortetracycline; Grain; Tylosin; Edetic acid DO - http://dx.doi.org/10.1016/j.chroma.2010.02.081 ER - TY - GEN T1 - Warning Letters: January 2010 to April 2010 AN - 504198901 AB - A list of warning letters issued from January 2010 to April 2010 due to violations of the Federal Food, Drug, and Cosmetic Act, is presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 22 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Letters KW - Violations KW - Federal regulation KW - Animal care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504198901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Warning+Letters%3A+January+2010+to+April+2010&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-04 ER - TY - GEN T1 - Focus on Learning: CVM Hosted Lecture on Heartworm and Associated Diseases AN - 504082520 AB - The Center for Veterinary Medicine's Learning Management Institute hosted John W. McCall for a talk about emerging issues in heartworm disease and associated diseases. The event is a part of the spring semester's program of scientific lectures. McCall's lecture focused on the association between Wolbachia and the filarial nematode Dirofilaria immitis, better known as heartworm. JF - FDA Veterinarian AU - Mclean, Melanie Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 4 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Public speaking KW - Veterinary medicine KW - Parasites KW - Animal diseases KW - McCall, John W UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504082520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=Focus+on+Learning%3A+CVM+Hosted+Lecture+on+Heartworm+and+Associated+Diseases&rft.au=Mclean%2C+Melanie&rft.aulast=Mclean&rft.aufirst=Melanie&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - People - McCall, John W N1 - Last updated - 2011-11-03 ER - TY - GEN T1 - Spotlight On: Dr. Lynne Oliver, Office of New Animal Drug Evaluation AN - 504082490 AB - Lynne Oliver, Division of Therapeutic Drugs for Non-Food Animals, attended the first annual North American Veterinary Regenerative Medicine Conference, which was held March 5 and 6, 2010, in Buellton CA. It focused on regenerative medicine in horses. Oliver participated in the roundtable session to explain CVM's current regulatory and approval processes for new animal drugs. JF - FDA Veterinarian AU - McLean, Melanie Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 2 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Veterinary medicine KW - Conferences KW - Horses KW - Drugs KW - Oliver, Lynne KW - Buellton California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504082490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Spotlight+On%3A+Dr.+Lynne+Oliver%2C+Office+of+New+Animal+Drug+Evaluation&rft.au=McLean%2C+Melanie&rft.aulast=McLean&rft.aufirst=Melanie&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - People - Oliver, Lynne N1 - Last updated - 2011-11-04 ER - TY - GEN T1 - CVM Updates: January 2010 to April 2010 AN - 504006873 AB - Updates of the Center for Veterinary Medicine from January 2010 to April 2010 are presented. JF - FDA Veterinarian AU - Anonymous Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 18 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Veterinary medicine KW - Special events UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504006873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Updates%3A+January+2010+to+April+2010&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-03 ER - TY - GEN T1 - CVM's International Outreach Activities in China and South Africa AN - 504006859 AB - Robinson discusses FDA's CVM and Office of International Programs (OIP) that perform a number of outreach activities with different countries to help FDA fulfill its public health mission. Two of which are in China and South Africa. Details are presented. JF - FDA Veterinarian AU - Robinson, Brandi Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Veterinary medicine KW - Public health KW - South Africa KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504006859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM%27s+International+Outreach+Activities+in+China+and+South+Africa&rft.au=Robinson%2C+Brandi&rft.aulast=Robinson&rft.aufirst=Brandi&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-03 ER - TY - GEN T1 - CVM Hot Topics AN - 504004363 AB - Special events happening in the Center for Veterinary Medicine are presented. JF - FDA Veterinarian AU - Cameron, Shannon AU - Bradbury, Shannon AU - Oeller, Meg AU - McLean, Melanie AU - Martinez, Marilyn AU - Stamper, Carmen Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 8 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Special events KW - Veterinary medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504004363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Hot+Topics&rft.au=Cameron%2C+Shannon%3BBradbury%2C+Shannon%3BOeller%2C+Meg%3BMcLean%2C+Melanie%3BMartinez%2C+Marilyn%3BStamper%2C+Carmen&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-04 ER - TY - GEN T1 - CVM Research: CVM's OR Develops New PCR-Based Method for Testing Animal Feed AN - 504004349 AB - The Office of Research of the US Food and Drug Administration's Center for Veterinary Medicine recently developed a new method for testing animal feed for prohibited materials. The method relies on polymerase chain reaction, a molecular technique that amplifies small amounts of genetic material (DNA or RNA) to produce larger amounts for analysis. It is expected to enhance the FDA's ability to make sure animal feed is safe and free of prohibited materials that may spread the agent thought to cause bovine spongiform encephalopathy. JF - FDA Veterinarian AU - Mclean, Melanie AU - Myers, Michael Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 4 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Veterinary medicine KW - Animals KW - Food KW - Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504004349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Research%3A+CVM%27s+OR+Develops+New+PCR-Based+Method+for+Testing+Animal+Feed&rft.au=Mclean%2C+Melanie%3BMyers%2C+Michael&rft.aulast=Mclean&rft.aufirst=Melanie&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Document feature - Photographs; Graphs; References N1 - Last updated - 2011-11-04 ER - TY - GEN T1 - Ask CVM: Travel Training for You and Your Pets AN - 504002203 AB - Several tips on animal care during travels are presented. Details are discussed. JF - FDA Veterinarian AU - Steel, Ashley Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 7 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Animals KW - Animal care KW - Travel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504002203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FDA+Veterinarian&rft.atitle=Ask+CVM%3A+Travel+Training+for+You+and+Your+Pets&rft.au=Steel%2C+Ashley&rft.aulast=Steel&rft.aufirst=Ashley&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-03 ER - TY - GEN T1 - CVM Participates in Social Media Outreach AN - 504002175 AB - FDA's Center for Veterinary Medicine is using social media to connect with consumers, veterinarians, and industry to share important animal health and safety tips, public health updates, and product recalls. Further information can be found at http://www.fda.gov/PetHealthWidget. JF - FDA Veterinarian AU - Cameron, Shannon Y1 - 2010/04/30/ PY - 2010 DA - 2010 Apr 30 SP - 1 CY - Rockville PB - U.S. Food & Drug Administration, Center for Veterinary Medicine VL - 1 IS - 1 KW - Veterinary Science KW - Veterinary medicine KW - Social networks KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/504002175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apublichealth&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=FDA+Veterinarian&rft.atitle=CVM+Participates+in+Social+Media+Outreach&rft.au=Cameron%2C+Shannon&rft.aulast=Cameron&rft.aufirst=Shannon&rft.date=2010-04-30&rft.volume=1&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=FDA+Veterinarian&rft.issn=10576223&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Center for Veterinary Medicine N1 - Copyright - Copyright U.S. Food & Drug Administration, Center for Veterinary Medicine Apr 30, 2010 N1 - Last updated - 2011-11-03 ER - TY - CPAPER T1 - New Approaches to Assess the Safety of Novel Adjuvants T2 - Thirteenth Annual Conference on Vaccine Research AN - 754206490; 5762508 JF - Thirteenth Annual Conference on Vaccine Research AU - Golding, Hana Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Adjuvants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754206490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=New+Approaches+to+Assess+the+Safety+of+Novel+Adjuvants&rft.au=Golding%2C+Hana&rft.aulast=Golding&rft.aufirst=Hana&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Influenza a Np and m2 Vaccination Protects Mice and Ferrets against Virulent h1n1 and h5n1 Challenge T2 - Thirteenth Annual Conference on Vaccine Research AN - 754200180; 5762497 JF - Thirteenth Annual Conference on Vaccine Research AU - Price, G AU - Soboleski1, M. AU - Lo, C. AU - Misplon, J AU - Epstein, S AU - Pappas, C AU - Houser, K AU - Tumpey, T Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Mice KW - Influenza KW - Vaccination KW - Influenza A KW - Mustela KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754200180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Influenza+a+Np+and+m2+Vaccination+Protects+Mice+and+Ferrets+against+Virulent+h1n1+and+h5n1+Challenge&rft.au=Price%2C+G%3BSoboleski1%2C+M.%3BLo%2C+C.%3BMisplon%2C+J%3BEpstein%2C+S%3BPappas%2C+C%3BHouser%2C+K%3BTumpey%2C+T&rft.aulast=Price&rft.aufirst=G&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Alternative Approaches to Measure Responses to Live, Attenuated Influenza Vaccine T2 - Thirteenth Annual Conference on Vaccine Research AN - 754194319; 5762510 JF - Thirteenth Annual Conference on Vaccine Research AU - Harris, K Y1 - 2010/04/26/ PY - 2010 DA - 2010 Apr 26 KW - Vaccines KW - Influenza KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754194319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.atitle=Alternative+Approaches+to+Measure+Responses+to+Live%2C+Attenuated+Influenza+Vaccine&rft.au=Harris%2C+K&rft.aulast=Harris&rft.aufirst=K&rft.date=2010-04-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Thirteenth+Annual+Conference+on+Vaccine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/vaccine10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Peptide Vaccines and Peptides Therapeutics T2 - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AN - 754236684; 5772074 JF - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AU - Gubina, Elena AU - Meneguz, Annarita AU - Stahlbom, Axel AU - Thurmer, Rene AU - Longer, Mark AU - Larsson, Peter Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Vaccines KW - Peptides KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.atitle=Peptide+Vaccines+and+Peptides+Therapeutics&rft.au=Gubina%2C+Elena%3BMeneguz%2C+Annarita%3BStahlbom%2C+Axel%3BThurmer%2C+Rene%3BLonger%2C+Mark%3BLarsson%2C+Peter&rft.aulast=Gubina&rft.aufirst=Elena&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/TIDES/agenda.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Oligonucleotide Therapeutics T2 - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AN - 754236649; 5772073 JF - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AU - Gubina, Elena AU - Meneguz, Annarita AU - Stahlbom, Axel AU - Thurmer, Rene Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Oligonucleotides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754236649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.atitle=Oligonucleotide+Therapeutics&rft.au=Gubina%2C+Elena%3BMeneguz%2C+Annarita%3BStahlbom%2C+Axel%3BThurmer%2C+Rene&rft.aulast=Gubina&rft.aufirst=Elena&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/TIDES/agenda.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - FDA Perspective on the Development of Peptide-Based Therapeutic Vaccines. T2 - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AN - 754225440; 5772063 JF - 2010 TIDES Conference on Oligonucleotide and Peptide: Technology and Product Development (TIDES 2010) AU - Gubina, Elena Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Vaccines KW - FDA KW - Peptides KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754225440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.atitle=FDA+Perspective+on+the+Development+of+Peptide-Based+Therapeutic+Vaccines.&rft.au=Gubina%2C+Elena&rft.aulast=Gubina&rft.aufirst=Elena&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+TIDES+Conference+on+Oligonucleotide+and+Peptide%3A+Technology+and+Product+Development+%28TIDES+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/TIDES/agenda.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Vector Prime-protein Boost Vaccine for Breast Cancer T2 - BIT's Annual 3rd World Cancer Congress AN - 754199748; 5736904 JF - BIT's Annual 3rd World Cancer Congress AU - Deisseroth, Albert Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Vaccines KW - Breast cancer KW - Cancer vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754199748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Vector+Prime-protein+Boost+Vaccine+for+Breast+Cancer&rft.au=Deisseroth%2C+Albert&rft.aulast=Deisseroth&rft.aufirst=Albert&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Vaccine Platform for Cancer and Infectious Diseases T2 - BIT's Annual 3rd World Cancer Congress AN - 754164975; 5736694 JF - BIT's Annual 3rd World Cancer Congress AU - Deisseroth, Albert Y1 - 2010/04/25/ PY - 2010 DA - 2010 Apr 25 KW - Cancer KW - Vaccines KW - Cancer vaccines KW - Infectious diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754164975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.atitle=Vaccine+Platform+for+Cancer+and+Infectious+Diseases&rft.au=Deisseroth%2C+Albert&rft.aulast=Deisseroth&rft.aufirst=Albert&rft.date=2010-04-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BIT%27s+Annual+3rd+World+Cancer+Congress&rft.issn=&rft_id=info:doi/ L2 - http://www.bitlifesciences.com/Cancer2010/Breast/Program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Peptides panned from a phage-displayed random peptide library are useful for the detection of Bacillus anthracis surrogates B. cereus 4342 and B. anthracis Sterne AN - 759308948; 13199256 AB - Recent use of Bacillus anthracis as a bioweapon has highlighted the need for a sensitive monitoring system. Current bacterial detection tests use antibodies as bio-molecular recognition elements which have limitations with regard to time, specificity and sensitivity, creating the need for new and improved cost-effective high-affinity detection probes. In this study, we screened a commercially available bacteriophage-displayed random peptide library using Bacillus cereus 4342 cells as bait to identify peptides that could be used for detection of Bacillus. The method enabled us to identify two 12-amino acid consensus peptide sequences that specifically bind to B. cereus 4342 and B. anthracis Sterne, the nonpathogenic surrogates of B. anthracis strain. The two Bacillus-binding peptides (named BBP-1 and BBP-2) were synthesized with biotin tag to confirm their binding by four independent detection assays. Dot-blot analysis revealed that the peptides bind specifically to B. cereus 4342 and B. anthracis Sterne. Quantitative analysis of this interaction by ELISA and fluorometry demonstrated a detection sensitivity of 102 colony forming U/ml (CFU/ml) by both assays. When the peptides were used in combination with Qdots, the sensitivity was enhanced further by enabling detection of even a single bacterium by fluorescence microscopy. Immunoblot analysis and protein sequencing showed that BBP-1 and BBP-2 bound to the S-layer protein of B. anthracis Sterne. Overall, our findings validate the usefulness of synthetic versions of phage-derived peptides in combination with Qdot-liquid nanocrystals as high sensitivity bioprobes for various microbial detection platforms. JF - Biochemical and Biophysical Research Communications AU - Sainath Rao, Shilpakala AU - Mohan, Ketha VK AU - Nguyen, Nga AU - Abraham, Bindu AU - Abdouleva, Galina AU - Zhang, Pei AU - Atreya, Chintamani D AD - Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 SP - 93 EP - 98 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 395 IS - 1 SN - 0006-291X, 0006-291X KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Toxicology Abstracts KW - Bacillus anthracis KW - Counter-terrorism KW - Peptide ligands KW - Phage-display KW - Plasma KW - Quantum dots KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - Colonies KW - Colony-forming cells KW - Probes KW - Bacillus cereus KW - Fluorometry KW - Crystals KW - Peptide libraries KW - Biotin KW - X 24370:Natural Toxins KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759308948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Peptides+panned+from+a+phage-displayed+random+peptide+library+are+useful+for+the+detection+of+Bacillus+anthracis+surrogates+B.+cereus+4342+and+B.+anthracis+Sterne&rft.au=Sainath+Rao%2C+Shilpakala%3BMohan%2C+Ketha+VK%3BNguyen%2C+Nga%3BAbraham%2C+Bindu%3BAbdouleva%2C+Galina%3BZhang%2C+Pei%3BAtreya%2C+Chintamani+D&rft.aulast=Sainath+Rao&rft.aufirst=Shilpakala&rft.date=2010-04-23&rft.volume=395&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2010.03.145 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Colonies; Antibodies; Enzyme-linked immunosorbent assay; Colony-forming cells; Probes; Fluorometry; Crystals; Peptide libraries; Biotin; Bacillus cereus; Bacillus anthracis DO - http://dx.doi.org/10.1016/j.bbrc.2010.03.145 ER - TY - CPAPER T1 - Prospective Study Designs: Convenience Cohorts Versus Randomized Samples T2 - Spring Practice and Research Forum of the American College of Clinical Pharmacy (ACCP 2010) AN - 754309230; 5866045 JF - Spring Practice and Research Forum of the American College of Clinical Pharmacy (ACCP 2010) AU - Pacanowski, Michael AU - Lee, Craig Y1 - 2010/04/23/ PY - 2010 DA - 2010 Apr 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754309230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Spring+Practice+and+Research+Forum+of+the+American+College+of+Clinical+Pharmacy+%28ACCP+2010%29&rft.atitle=Prospective+Study+Designs%3A+Convenience+Cohorts+Versus+Randomized+Samples&rft.au=Pacanowski%2C+Michael%3BLee%2C+Craig&rft.aulast=Pacanowski&rft.aufirst=Michael&rft.date=2010-04-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Spring+Practice+and+Research+Forum+of+the+American+College+of+Clinical+Pharmacy+%28ACCP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/meetings/sf10/schedule.aspx?mode=search&type=all LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Method for Reducing Variability in Bending Strength T2 - 2010 Annual Meeting and Exposition of the Society For Biomaterials AN - 754192551; 5751245 JF - 2010 Annual Meeting and Exposition of the Society For Biomaterials AU - Vesnovsky, O AU - Demian, H AU - Woods, T AU - Topoleski, T Y1 - 2010/04/21/ PY - 2010 DA - 2010 Apr 21 KW - Mechanical properties KW - Deformation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754192551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+and+Exposition+of+the+Society+For+Biomaterials&rft.atitle=A+Method+for+Reducing+Variability+in+Bending+Strength&rft.au=Vesnovsky%2C+O%3BDemian%2C+H%3BWoods%2C+T%3BTopoleski%2C+T&rft.aulast=Vesnovsky&rft.aufirst=O&rft.date=2010-04-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+and+Exposition+of+the+Society+For+Biomaterials&rft.issn=&rft_id=info:doi/ L2 - http://www.biomaterials.org/Meetings/10AnnualMeeting/files/preliminary LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Deficiencies in New Drug Applications T2 - Interphex 2010: Conference and Exhibition AN - 754221730; 5771809 JF - Interphex 2010: Conference and Exhibition AU - Iser, Robert AU - Lostritto, Richard AU - Srinivasan, Aloka Y1 - 2010/04/20/ PY - 2010 DA - 2010 Apr 20 KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754221730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Interphex+2010%3A+Conference+and+Exhibition&rft.atitle=Deficiencies+in+New+Drug+Applications&rft.au=Iser%2C+Robert%3BLostritto%2C+Richard%3BSrinivasan%2C+Aloka&rft.aulast=Iser&rft.aufirst=Robert&rft.date=2010-04-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Interphex+2010%3A+Conference+and+Exhibition&rft.issn=&rft_id=info:doi/ L2 - http://interphex2010.conferencepath.com/program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The Association Between Parental and Provider Vaccination Beliefs: A Case Control Study T2 - 44th National Immunization Conference (NIC 2010) AN - 754206248; 5751665 JF - 44th National Immunization Conference (NIC 2010) AU - Mergler, Michelle AU - Pan, William AU - Omer, Saad AU - Navar, Anne AU - Orenstein, Walter AU - Marcuse, Edgar AU - Taylor, James AU - deHart, M AU - Carter, Terrell AU - Halsey, Neal AU - Salmon, Daniel Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 KW - Vaccination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754206248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+National+Immunization+Conference+%28NIC+2010%29&rft.atitle=The+Association+Between+Parental+and+Provider+Vaccination+Beliefs%3A+A+Case+Control+Study&rft.au=Mergler%2C+Michelle%3BPan%2C+William%3BOmer%2C+Saad%3BNavar%2C+Anne%3BOrenstein%2C+Walter%3BMarcuse%2C+Edgar%3BTaylor%2C+James%3BdeHart%2C+M%3BCarter%2C+Terrell%3BHalsey%2C+Neal%3BSalmon%2C+Daniel&rft.aulast=Mergler&rft.aufirst=Michelle&rft.date=2010-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+National+Immunization+Conference+%28NIC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2010/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Parent and Provider Vaccine Concerns: From Research to Practice T2 - 44th National Immunization Conference (NIC 2010) AN - 754198548; 5751664 JF - 44th National Immunization Conference (NIC 2010) AU - Marshall, Stephanie Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754198548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+National+Immunization+Conference+%28NIC+2010%29&rft.atitle=Parent+and+Provider+Vaccine+Concerns%3A+From+Research+to+Practice&rft.au=Marshall%2C+Stephanie&rft.aulast=Marshall&rft.aufirst=Stephanie&rft.date=2010-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+National+Immunization+Conference+%28NIC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2010/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Imported Case of Measles (Rubeola); A Multiagency Mitigation Approach T2 - 44th National Immunization Conference (NIC 2010) AN - 754192779; 5751583 JF - 44th National Immunization Conference (NIC 2010) AU - Lowrey, Mary AU - Chin, Martin AU - Fasoranti, Tai AU - Khuwaja, Salma AU - Hyewon, Lee-Han AU - Adebowale, Awosika-Olumo Y1 - 2010/04/19/ PY - 2010 DA - 2010 Apr 19 KW - Mitigation KW - Measles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754192779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+National+Immunization+Conference+%28NIC+2010%29&rft.atitle=Imported+Case+of+Measles+%28Rubeola%29%3B+A+Multiagency+Mitigation+Approach&rft.au=Lowrey%2C+Mary%3BChin%2C+Martin%3BFasoranti%2C+Tai%3BKhuwaja%2C+Salma%3BHyewon%2C+Lee-Han%3BAdebowale%2C+Awosika-Olumo&rft.aulast=Lowrey&rft.aufirst=Mary&rft.date=2010-04-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+National+Immunization+Conference+%28NIC+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://cdc.confex.com/cdc/nic2010/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Pulmonary responses to multiwalled carbon nanotube exposure T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754259635; 5796811 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Castranova, Vince Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Nanotechnology KW - Carbon KW - Lung KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754259635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Pulmonary+responses+to+multiwalled+carbon+nanotube+exposure&rft.au=Castranova%2C+Vince&rft.aulast=Castranova&rft.aufirst=Vince&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754253543; 5799336 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook, Beverly AU - McCaskill-Stevens, Worta Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754253543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=Lyn-Cook%2C+Beverly%3BMcCaskill-Stevens%2C+Worta&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Keys to Cancer Prevention T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754241596; 5797082 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Lyn-Cook, Beverly Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Cancer KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754241596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Keys+to+Cancer+Prevention&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Regulatory perspective of the role of pharmacokinetics in drug discovery and development T2 - 101st Annual Meeting of the American Association for Cancer Research AN - 754238479; 5796734 JF - 101st Annual Meeting of the American Association for Cancer Research AU - Bullock, Julie Y1 - 2010/04/17/ PY - 2010 DA - 2010 Apr 17 KW - Drug discovery KW - Pharmacokinetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754238479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.atitle=Regulatory+perspective+of+the+role+of+pharmacokinetics+in+drug+discovery+and+development&rft.au=Bullock%2C+Julie&rft.aulast=Bullock&rft.aufirst=Julie&rft.date=2010-04-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=101st+Annual+Meeting+of+the+American+Association+for+Cancer+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-101st-ann LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Separation and preconcentration of trace level of lead in one drop of blood sample by using graphite furnace atomic absorption spectrometry AN - 745690939; 13017033 AB - Drop-to-drop solvent microextraction (DDSME) assisted with ultrasonication is applied for the determination of lead in one drop (30I14L) of blood sample by using graphite furnace atomic absorption spectrometry (GF-AAS). The optimum extraction efficiency of lead was observed for 10min extraction time at pH 5.0 with 2I14L of organic solvent that containing 0.5M of Cyanex-302. The optimized methodology exhibited good linearity in the range of 0.3-30.0ngmLa1 lead with relative standard deviations (RSD) from 2.5 to 4.4%. The method is found to be simple and rapid for the analysis of lead in micro amount of blood sample with the limit of detection (LOD) of 0.08ngmLa1. The application of the proposed method has been successfully tested for the determination of lead in blood samples. The results showed that under the optimized experimental conditions, the method showed good sensitivity and recovery %, as well as advantages such as linearity, simplicity, low cost and high feasibility. JF - Journal of Hazardous Materials AU - Shrivas, Kamlesh AU - Patel, Devesh Kumar AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville pike, Building 29A, 2B20, Bethesda, MD 20892, United States Y1 - 2010/04/15/ PY - 2010 DA - 2010 Apr 15 SP - 414 EP - 417 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 176 IS - 1-3 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Environment Abstracts KW - Lead KW - Blood KW - Drop-to-drop solvent microextraction KW - Atomic absorption spectrometry KW - Feasibility studies KW - Sensitivity KW - Graphite KW - Solvents KW - Spectrometry KW - Standard deviation KW - Absorption KW - pH effects KW - pH KW - X 24360:Metals KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745690939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Separation+and+preconcentration+of+trace+level+of+lead+in+one+drop+of+blood+sample+by+using+graphite+furnace+atomic+absorption+spectrometry&rft.au=Shrivas%2C+Kamlesh%3BPatel%2C+Devesh+Kumar&rft.aulast=Shrivas&rft.aufirst=Kamlesh&rft.date=2010-04-15&rft.volume=176&rft.issue=1-3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2009.11.045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Standard deviation; Graphite; Solvents; pH effects; Lead; Spectrometry; Feasibility studies; Sensitivity; Absorption; pH DO - http://dx.doi.org/10.1016/j.jhazmat.2009.11.045 ER - TY - JOUR T1 - Occupational sunlight exposure and risk of renal cell carcinoma AN - 1017970163; 16689240 AB - BACKGROUND: Recent findings indicate that vitamin D obtained from ultraviolet (UV) exposure may reduce the risk of several different cancers. Vitamin D is metabolized to its active form within the kidney, which is the major organ for vitamin D metabolism and activity. Because both the incidence of renal cell carcinoma (RCC) and the prevalence of vitamin D deficiency have increased over the past few decades, in the current study, the authors explored whether occupational UV exposure was associated with RCC risk. METHODS: A hospital-based, case-control study of 1097 patients with RCC (cases) and 1476 controls was conducted in 4 Central and Eastern European countries. Demographic and occupational information was collected to examine the association between occupational UV exposure and RCC risk. RESULTS: A significant reduction (24%-38%) in the risk of RCC was observed with increasing occupational UV exposure among men who participated in the study. No association between UV exposure and RCC risk was observed among women who participated. When the analyses were stratified by latitude as another estimate of sunlight intensity, a stronger reduction (71%-73%) in the risk of RCC was observed between UV exposure and cancer risk among men who resided at the highest latitudes. CONCLUSIONS: The current results suggested that, among men, there is an inverse association between occupational UV exposure and the risk of RCC. Replication studies are warranted to confirm these results. Cancer 2010. Published 2010 by the American Cancer Society. JF - Cancer AU - Karami, Sara AU - Boffetta, Paolo AU - Stewart, Patricia AU - Rothman, Nathaniel AU - Hunting, Katherine L AU - Dosemeci, Mustafa AU - Berndt, Sonja I AU - Brennan, Paul AU - Chow, Wong-Ho AU - Moore, Lee E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, karamis@mail.nih.gov Y1 - 2010/04/15/ PY - 2010 DA - 2010 Apr 15 SP - 2001 EP - 2010 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 116 IS - 8 SN - 1097-0142, 1097-0142 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Cancer KW - Demography KW - Kidney KW - Latitude KW - Metabolism KW - Organs KW - Risk reduction KW - Sunlight KW - Vitamins KW - demography KW - latitude KW - sunlight KW - vitamins KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017970163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Occupational+sunlight+exposure+and+risk+of+renal+cell+carcinoma&rft.au=Karami%2C+Sara%3BBoffetta%2C+Paolo%3BStewart%2C+Patricia%3BRothman%2C+Nathaniel%3BHunting%2C+Katherine+L%3BDosemeci%2C+Mustafa%3BBerndt%2C+Sonja+I%3BBrennan%2C+Paul%3BChow%2C+Wong-Ho%3BMoore%2C+Lee+E&rft.aulast=Karami&rft.aufirst=Sara&rft.date=2010-04-15&rft.volume=116&rft.issue=8&rft.spage=2001&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=10970142&rft_id=info:doi/10.1002%2Fcncr.24939 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cncr.24939/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Last updated - 2012-07-27 N1 - SubjectsTermNotLitGenreText - demography; Risk reduction; sunlight; Organs; Cancer; Demography; vitamins; Vitamins; Kidney; Latitude; Sunlight; latitude; Metabolism DO - http://dx.doi.org/10.1002/cncr.24939 ER - TY - CPAPER T1 - Long Term Follow-up of Injecting Drug Users Suggests Protective Immunity against Hcv Reinfection and Superinfection with a Similar Genotype T2 - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AN - 754281902; 5830795 JF - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AU - van de Laar, T AU - Rondy, M AU - Bruisten, S AU - Prins, M AU - van Ballegooijen, M Y1 - 2010/04/14/ PY - 2010 DA - 2010 Apr 14 KW - Drug abuse KW - Genotypes KW - Superinfection KW - Immunity KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754281902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.atitle=Long+Term+Follow-up+of+Injecting+Drug+Users+Suggests+Protective+Immunity+against+Hcv+Reinfection+and+Superinfection+with+a+Similar+Genotype&rft.au=van+de+Laar%2C+T%3BRondy%2C+M%3BBruisten%2C+S%3BPrins%2C+M%3Bvan+Ballegooijen%2C+M&rft.aulast=van+de+Laar&rft.aufirst=T&rft.date=2010-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/easl2010/orals/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Who Gets Infected? Virologic and Immunologic Aspects of Acute Infection and Reinfection T2 - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AN - 754276034; 5829997 JF - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AU - van de Laar, T Y1 - 2010/04/14/ PY - 2010 DA - 2010 Apr 14 KW - Infection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754276034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.atitle=Who+Gets+Infected%3F+Virologic+and+Immunologic+Aspects+of+Acute+Infection+and+Reinfection&rft.au=van+de+Laar%2C+T&rft.aulast=van+de+Laar&rft.aufirst=T&rft.date=2010-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/easl2010/orals/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - No Evidence for an Impact on Mortality in Chronically Hcv Infected Drug Users T2 - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AN - 754274316; 5831190 JF - 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) AU - Grady, B AU - Krol, A AU - van den Berg, C AU - van der Helm, J AU - Schinkel, J AU - Coutinho, R AU - Prins, M Y1 - 2010/04/14/ PY - 2010 DA - 2010 Apr 14 KW - Mortality KW - Drug abuse KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754274316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.atitle=No+Evidence+for+an+Impact+on+Mortality+in+Chronically+Hcv+Infected+Drug+Users&rft.au=Grady%2C+B%3BKrol%2C+A%3Bvan+den+Berg%2C+C%3Bvan+der+Helm%2C+J%3BSchinkel%2C+J%3BCoutinho%2C+R%3BPrins%2C+M&rft.aulast=Grady&rft.aufirst=B&rft.date=2010-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+European+Association+for+the+Study+of+the+Liver+%28EASL+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/easl2010/orals/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Novel Multifunctional Confocal Imaging and Sensing Approaches in Biophotonics and Nanobiophotonics T2 - 2010 SPIE Europe Photonics Europe Conference AN - 754258474; 5822222 JF - 2010 SPIE Europe Photonics Europe Conference AU - Ilev, Ilko Y1 - 2010/04/12/ PY - 2010 DA - 2010 Apr 12 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754258474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SPIE+Europe+Photonics+Europe+Conference&rft.atitle=Novel+Multifunctional+Confocal+Imaging+and+Sensing+Approaches+in+Biophotonics+and+Nanobiophotonics&rft.au=Ilev%2C+Ilko&rft.aulast=Ilev&rft.aufirst=Ilko&rft.date=2010-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SPIE+Europe+Photonics+Europe+Conference&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/Photonics%20Europe%20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Creating Dynamic Series Charts Using Base SAS, SAS/GRAPH, and the Annotate Facility T2 - 2010 SAS Global Forum AN - 754167309; 5736485 JF - 2010 SAS Global Forum AU - Ju, Jun AU - Nowlin, Susan AU - Sestito, John Y1 - 2010/04/11/ PY - 2010 DA - 2010 Apr 11 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754167309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SAS+Global+Forum&rft.atitle=Creating+Dynamic+Series+Charts+Using+Base+SAS%2C+SAS%2FGRAPH%2C+and+the+Annotate+Facility&rft.au=Ju%2C+Jun%3BNowlin%2C+Susan%3BSestito%2C+John&rft.aulast=Ju&rft.aufirst=Jun&rft.date=2010-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SAS+Global+Forum&rft.issn=&rft_id=info:doi/ L2 - http://sgf2010.confnav.com/sgf2010/web/reports/abstract.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Analysis of polyhexamethylene biguanide in multipurpose contact lens solutions T2 - 41th Middle Atlantic Regional meeting (MARM 2010) AN - 754208545; 5768616 JF - 41th Middle Atlantic Regional meeting (MARM 2010) AU - Lucas, Anne AU - Gordon, Edward Y1 - 2010/04/10/ PY - 2010 DA - 2010 Apr 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754208545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.atitle=Analysis+of+polyhexamethylene+biguanide+in+multipurpose+contact+lens+solutions&rft.au=Lucas%2C+Anne%3BGordon%2C+Edward&rft.aulast=Lucas&rft.aufirst=Anne&rft.date=2010-04-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.marmacs.org/2010/docs/MARM-2010-Program-2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Chemoenzymatic synthesis of conjugate polysialic acid vaccines T2 - 41th Middle Atlantic Regional meeting (MARM 2010) AN - 754208513; 5768431 JF - 41th Middle Atlantic Regional meeting (MARM 2010) AU - McCarthy, Pumtiwitt AU - Mosley, Sylvester AU - Saksena, Rina AU - Peterson, Dwight AU - Vionnet, Justine AU - Vann, Willie Y1 - 2010/04/10/ PY - 2010 DA - 2010 Apr 10 KW - Vaccines KW - Polysialic acid KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754208513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.atitle=Chemoenzymatic+synthesis+of+conjugate+polysialic+acid+vaccines&rft.au=McCarthy%2C+Pumtiwitt%3BMosley%2C+Sylvester%3BSaksena%2C+Rina%3BPeterson%2C+Dwight%3BVionnet%2C+Justine%3BVann%2C+Willie&rft.aulast=McCarthy&rft.aufirst=Pumtiwitt&rft.date=2010-04-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.marmacs.org/2010/docs/MARM-2010-Program-2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Drug elution kinetics and structure of absorbable matrix coatings T2 - 41th Middle Atlantic Regional meeting (MARM 2010) AN - 754195220; 5768523 JF - 41th Middle Atlantic Regional meeting (MARM 2010) AU - Sarkar Das, Srilekha AU - McDermott, Martin AU - Anne Lucas, Anne AU - Cargal, Timothy AU - Patel, Lakir AU - Saylor, David AU - Patwardhan, Dinesh Y1 - 2010/04/10/ PY - 2010 DA - 2010 Apr 10 KW - Kinetics KW - Coating materials KW - Drugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754195220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.atitle=Drug+elution+kinetics+and+structure+of+absorbable+matrix+coatings&rft.au=Sarkar+Das%2C+Srilekha%3BMcDermott%2C+Martin%3BAnne+Lucas%2C+Anne%3BCargal%2C+Timothy%3BPatel%2C+Lakir%3BSaylor%2C+David%3BPatwardhan%2C+Dinesh&rft.aulast=Sarkar+Das&rft.aufirst=Srilekha&rft.date=2010-04-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=41th+Middle+Atlantic+Regional+meeting+%28MARM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.marmacs.org/2010/docs/MARM-2010-Program-2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Long Term Follow-up of Injecting Drug Users Suggests Protective Immunity against Hcv Reinfection and Superinfection with a Similar Genotype T2 - 4th European Congress of Virology AN - 754227445; 5771537 JF - 4th European Congress of Virology AU - van de Laar, T.J. AU - Rondy, M AU - Bruisten, S AU - Prins, M AU - van Ballegooijen, M Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Drug abuse KW - Genotypes KW - Superinfection KW - Immunity KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754227445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+European+Congress+of+Virology&rft.atitle=Long+Term+Follow-up+of+Injecting+Drug+Users+Suggests+Protective+Immunity+against+Hcv+Reinfection+and+Superinfection+with+a+Similar+Genotype&rft.au=van+de+Laar%2C+T.J.%3BRondy%2C+M%3BBruisten%2C+S%3BPrins%2C+M%3Bvan+Ballegooijen%2C+M&rft.aulast=van+de+Laar&rft.aufirst=T.J.&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology2010.org/pdf/AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Perceived Family Support Associated with Decreased Alcohol Use among Iowa Youth T2 - 2010 Annual Meeting of the Society for Adolescent Medicine (SAM 2010) AN - 754177179; 5724229 JF - 2010 Annual Meeting of the Society for Adolescent Medicine (SAM 2010) AU - Fournier, Mary AU - Quinlisk, Patricia AU - Garvey, Ann AU - Goddard, Judy AU - Lyss, Sheryl Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - USA, Iowa KW - Alcohols KW - Perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754177179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+Society+for+Adolescent+Medicine+%28SAM+2010%29&rft.atitle=Perceived+Family+Support+Associated+with+Decreased+Alcohol+Use+among+Iowa+Youth&rft.au=Fournier%2C+Mary%3BQuinlisk%2C+Patricia%3BGarvey%2C+Ann%3BGoddard%2C+Judy%3BLyss%2C+Sheryl&rft.aulast=Fournier&rft.aufirst=Mary&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+Society+for+Adolescent+Medicine+%28SAM+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.adolescenthealth.org/AM/Template.cfm?Section=Research_Poste LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - The JNK pathway interacts with dpp signaling in the formation of head capsule T2 - 51st Annual Drosophila Research Conference AN - 754156509; 5731084 JF - 51st Annual Drosophila Research Conference AU - Park, Sung-Yeon AU - Stultz, Brian AU - Hursh, Deborah Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Signal transduction KW - Head KW - C-Jun amino-terminal kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754156509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Drosophila+Research+Conference&rft.atitle=The+JNK+pathway+interacts+with+dpp+signaling+in+the+formation+of+head+capsule&rft.au=Park%2C+Sung-Yeon%3BStultz%2C+Brian%3BHursh%2C+Deborah&rft.aulast=Park&rft.aufirst=Sung-Yeon&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/2010/pdf/programbook/abstracts_final.pd LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - A Universal Virus Detection Assay - Innovative Molecular Tools for Identification of New Viruses T2 - 4th European Congress of Virology AN - 1313015707; 6146583 JF - 4th European Congress of Virology AU - Uhlenhaut, C AU - McClenahan, S AU - Krause, P AU - Scherba, G AU - Sosnovtsev, S AU - Bok, K AU - Kapikian, A AU - Green, K Y1 - 2010/04/07/ PY - 2010 DA - 2010 Apr 07 KW - Innovations KW - Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1313015707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+European+Congress+of+Virology&rft.atitle=A+Universal+Virus+Detection+Assay+-+Innovative+Molecular+Tools+for+Identification+of+New+Viruses&rft.au=Uhlenhaut%2C+C%3BMcClenahan%2C+S%3BKrause%2C+P%3BScherba%2C+G%3BSosnovtsev%2C+S%3BBok%2C+K%3BKapikian%2C+A%3BGreen%2C+K&rft.aulast=Uhlenhaut&rft.aufirst=C&rft.date=2010-04-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+European+Congress+of+Virology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurovirology2010.org/pdf/AbstractBook.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-26 N1 - Last updated - 2013-02-28 ER - TY - JOUR T1 - Analysis of the Role of Lead Resistivity in Specific Absorption Rate for Deep Brain Stimulator Leads at 3T MRI AN - 910653939; 15710853 AB - Magnetic resonance imaging (MRI) on patients with implanted deep brain stimulators (DBSs) can be hazardous because of the antenna-effect of leads exposed to the incident radio-frequency field. This study evaluated electromagnetic field and specific absorption rate (SAR) changes as a function of lead resistivity on an anatomically precise head model in a 3T system. The anatomical accuracy of our head model allowed for detailed modeling of the path of DBS leads between epidermis and the outer table. Our electromagnetic finite difference time domain (FDTD) analysis showed significant changes of 1 g and 10 g averaged SAR for the range of lead resistivity modeled, including highly conductive leads up to highly resistive leads. Antenna performance and whole-head SAR were sensitive to the presence of the DBS leads only within 10%, while changes of over one order of magnitude were observed for the peak 10 g averaged SAR, suggesting that local SAR values should be considered in DBS guidelines. With rho rm lead = rho rm copper , and the MRI coil driven to produce a whole-head SAR without leads of 3.2 W/kg, the 1 g averaged SAR was 1080 W/kg and the 10 g averaged SAR 120 W/kg at the tip of the DBS lead. Conversely, in the control case without leads, the 1 g and 10 g averaged SAR were 0.5 W/kg and 0.6 W/kg, respectively, in the same location. The SAR at the tip of lead was similar with electrically homogeneous and electrically heterogeneous models. Our results show that computational models can support the development of novel lead technology, properly balancing the requirements of SAR deposition at the tip of the lead and power dissipation of the system battery. JF - IEEE Transactions on Medical Imaging AU - Angelone, Leonardo M AU - Ahveninen, Jyrki AU - Belliveau, John W AU - Bonmassar, Giorgio AD - Division of Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, U.S. Food and Drug Administration, Harvard Medical School, Silver Spring, Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1029 EP - 1038 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 29 IS - 1-4 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Epidermis KW - Neuroimaging KW - Mathematical models KW - Head KW - Magnetic resonance imaging KW - Brain KW - Copper KW - Electromagnetic fields KW - Antennae KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910653939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Analysis+of+the+Role+of+Lead+Resistivity+in+Specific+Absorption+Rate+for+Deep+Brain+Stimulator+Leads+at+3T+MRI&rft.au=Angelone%2C+Leonardo+M%3BAhveninen%2C+Jyrki%3BBelliveau%2C+John+W%3BBonmassar%2C+Giorgio&rft.aulast=Angelone&rft.aufirst=Leonardo&rft.date=2010-04-01&rft.volume=29&rft.issue=1-4&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2040624 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Epidermis; Neuroimaging; Mathematical models; Head; Magnetic resonance imaging; Brain; Copper; Antennae; Electromagnetic fields; Models DO - http://dx.doi.org/10.1109/TMI.2010.2040624 ER - TY - JOUR T1 - Partial Least Squares: A Method to Estimate Efficient Channels for the Ideal Observers AN - 910650501; 15710852 AB - We advocate a task-based approach to the assessment of image quality using the Bayesian ideal observer. The Bayesian ideal observer provides an absolute upper bound for performance estimates. However, using the full images as inputs to the observer is often infeasible due to their high dimensionality. A practical alternative is to reduce the dimensionality of the images by applying channels, while approximating the ideal observer by an observer constrained to the channels. Laguerre-Gauss (LG) channels and those derived from the singular value decomposition (SVD) of the system operator have previously been used with the Bayesian ideal observer. However, the channelized observer with LG and SVD channels was only applicable in situations with a rotationally symmetric signal or known system operator, respectively. We investigate a method using partial least squares (PLS) to compute efficient channels directly from the images, without prior knowledge of the background, signal, or system operator. Results show that the channelized ideal observer with PLS channels approximates the nonchannelized observer, and does so with fewer channels than the observer with either LG or SVD channels. The images are reduced from 4096 pixel values to 20 channel outputs, yet preserve the salient information. Furthermore, PLS reveals that the background image statistics provide important information necessary in signal-detection tasks. Overall, PLS is shown to be a viable channel generation method and may be applicable to real-life situations. JF - IEEE Transactions on Medical Imaging AU - Witten, Joel M AU - Park, Subok AU - Myers, Kyle J AD - Division of Imaging and Applied Mathematics, Department of Statistics, Center for Devices and Radiological Health of the Food and Drug Administration, Columbia University, White Oak, Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 1050 EP - 1058 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 29 IS - 1-4 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Bayesian analysis KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/910650501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Partial+Least+Squares%3A+A+Method+to+Estimate+Efficient+Channels+for+the+Ideal+Observers&rft.au=Witten%2C+Joel+M%3BPark%2C+Subok%3BMyers%2C+Kyle+J&rft.aulast=Witten&rft.aufirst=Joel&rft.date=2010-04-01&rft.volume=29&rft.issue=1-4&rft.spage=1050&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2010.2041514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Statistics; Bayesian analysis DO - http://dx.doi.org/10.1109/TMI.2010.2041514 ER - TY - JOUR T1 - Genotoxicity of pyrrolizidine alkaloids AN - 883025952; 15241989 AB - Pyrrolizidine alkaloids (PAs) are common constituents of many plant species around the world. PA-containing plants are probably the most common poisonous plants affecting livestock and wildlife. They can inflict harm to humans through contaminated food sources, herbal medicines and dietary supplements. Half of the identified PAs are genotoxic and many of them are tumorigenic. The mutagenicity of PAs has been extensively studied in different biological systems. Upon metabolic activation, PAs produce DNA adducts, DNA cross-linking, DNA breaks, sister chromatid exchange, micronuclei, chromosomal aberrations, gene mutations and chromosome mutations in vivo and in vitro. PAs induced mutations in the cII gene of rat liver and in the p53 and K-ras genes of mouse liver tumors. It has been suggested that all PAs produce a set of (+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine-deriv ed DNA adducts and similar types of gene mutations. The signature types of mutations are G : C arrow right T : A transversion and tandem base substitutions. Overall, PAs are mutagenic in vivo and in vitro and their mutagenicity appears to be responsible for the carcinogenesis of PAs. Published in 2010 by John Wiley & Sons, Ltd. JF - Journal of Applied Toxicology AU - Chen, Tao AU - Mei, Nan AU - Fu, Peter P Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 183 EP - 196 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 3 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts KW - Sister chromatid exchange KW - Micronuclei KW - Transversion KW - pyrrolizidine alkaloids KW - Chromosomes KW - Food sources KW - Herbal medicines KW - Chromosome aberrations KW - DNA adducts KW - Mutagenicity KW - dietary supplements KW - Genotoxicity KW - Point mutation KW - Tumors KW - Livestock KW - p53 protein KW - DNA damage KW - K-Ras protein KW - Carcinogenesis KW - DNA KW - Liver KW - Mutation KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883025952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Genotoxicity+of+pyrrolizidine+alkaloids&rft.au=Chen%2C+Tao%3BMei%2C+Nan%3BFu%2C+Peter+P&rft.aulast=Chen&rft.aufirst=Tao&rft.date=2010-04-01&rft.volume=30&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1504 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1504/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - DNA adducts; Mutagenicity; Sister chromatid exchange; Point mutation; Genotoxicity; Micronuclei; Tumors; Transversion; p53 protein; Livestock; pyrrolizidine alkaloids; K-Ras protein; DNA damage; Chromosomes; Food sources; Carcinogenesis; Liver; Herbal medicines; Chromosome aberrations; dietary supplements; DNA; Mutation DO - http://dx.doi.org/10.1002/jat.1504 ER - TY - JOUR T1 - The Role of MicroRNA in Chemical Carcinogenesis AN - 867746690; 14317437 AB - Abstract not available. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 89 EP - 124 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 28 IS - 2 SN - 1059-0501, 1059-0501 KW - Toxicology Abstracts KW - Reviews KW - Carcinogenesis KW - miRNA KW - X 24500:Reviews, Legislation, Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867746690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=The+Role+of+MicroRNA+in+Chemical+Carcinogenesis&rft.au=Chen%2C+Tao&rft.aulast=Chen&rft.aufirst=Tao&rft.date=2010-04-01&rft.volume=28&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590501.2010.481477 L2 - http://www.informaworld.com/smpp/content~db=all~content=a923039493~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - miRNA; Carcinogenesis; Reviews DO - http://dx.doi.org/10.1080/10590501.2010.481477 ER - TY - JOUR T1 - Underground coal mining injury: A look at how age and experience relate to days lost from work following an injury AN - 867732250; 13020479 AB - Coal has been mined in the United States since colonial times and coal mining has always been a dangerous occupation. Despite the dangers involved in coal mining, coal is essential to the functioning of our society. Coal provides energy for products, businesses, and homes. Not only is coal mining a dangerous occupation, but, like many other industries, coal mining has also been referred to as a "graying occupation" as many coal miners are reaching retirement age. Younger workers possess certain advantages as older workers may have age-associated decrements in cognitive function, health, and recuperative ability. Although there are documented decreases in health and safety associated with age, there are also benefits at the workplace associated with increasing age. Increasing age brings about more experience and familiarity with the work environment. This study used the Mine Safety and Health Administration's (MSHA) database on accidents, injury, and illness from the years 2003 through 2007 to examine how age, experience at the current mine, total years experience as a coal miner, and experience in the current job affects injury severity. The results of the data indicated that there was a relationship between age and days lost as well as total mining experience and days lost following an injury. Furthermore, the data indicated an increased risk of overexertion injuries as age increases. These are important findings for the coal mining industry as many miners are more experienced and older. JF - Safety Science AU - Margolis, Katherine A AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, PO Box 18070, Pittsburgh, PA 15236, USA, KMargolis@cdc.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 417 EP - 421 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 48 IS - 4 SN - 0925-7535, 0925-7535 KW - Health & Safety Science Abstracts KW - Age KW - Safety regulations KW - Injuries KW - Occupational safety KW - Coal KW - Mines KW - USA KW - Accidents KW - cognitive ability KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867732250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Safety+Science&rft.atitle=Underground+coal+mining+injury%3A+A+look+at+how+age+and+experience+relate+to+days+lost+from+work+following+an+injury&rft.au=Margolis%2C+Katherine+A&rft.aulast=Margolis&rft.aufirst=Katherine&rft.date=2010-04-01&rft.volume=48&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Safety+Science&rft.issn=09257535&rft_id=info:doi/10.1016%2Fj.ssci.2009.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Accidents; Age; cognitive ability; Safety regulations; Injuries; Occupational safety; Mining; Coal; Mines; USA DO - http://dx.doi.org/10.1016/j.ssci.2009.12.015 ER - TY - JOUR T1 - Using Information on Clinical Conditions to Predict High-Cost Patients AN - 839570531; 201101283 AB - Objective. To compare the ability of different models to predict prospectively whether someone will incur high medical expenditures. Data Source. Using nationally representative data from the Medical Expenditure Panel Survey (MEPS), prediction models were developed using cohorts initiated in 1996-1999 (N=52,918), and validated using cohorts initiated in 2000-2003 (N=61,155). Study Design. We estimated logistic regression models to predict being in the upper expenditure decile in Year 2 of a cohort, based on data from Year 1. We compared a summary risk score based on diagnostic cost group (DCG) prospective risk scores to a count of chronic conditions and indicators for 10 specific high-prevalence chronic conditions. We examined whether self-rated health and functional limitations enhanced prediction, controlling for clinical conditions. Models were evaluated using the Bayesian information criterion and the c-statistic. Principal Findings. Medical condition information substantially improved prediction of high expenditures beyond gender and age, with the DCG risk score providing the greatest improvement in prediction. The count of chronic conditions, self-reported health status, and functional limitations were significantly associated with future high expenditures, controlling for DCG score. A model including these variables had good discrimination (c=0.836). Conclusions. The number of chronic conditions merits consideration in future efforts to develop expenditure prediction models. While significant, self-rated health and indicators of functioning improved prediction only slightly. Adapted from the source document. JF - Health Services Research AU - Fleishman, John A AU - Cohen, Joel W AD - Center for Financing, Access, and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850 Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 532 EP - 552 PB - Blackwell Publishers, Oxford UK VL - 45 IS - 2 SN - 0017-9124, 0017-9124 KW - Health care expenditures prediction models DCG models chronic conditions KW - Health costs KW - Chronic sickness KW - Expenditure KW - Gender KW - Health status KW - Functional impairment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839570531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Using+Information+on+Clinical+Conditions+to+Predict+High-Cost+Patients&rft.au=Fleishman%2C+John+A%3BCohen%2C+Joel+W&rft.aulast=Fleishman&rft.aufirst=John&rft.date=2010-04-01&rft.volume=45&rft.issue=2&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2009.01080.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Expenditure; Chronic sickness; Health status; Functional impairment; Gender; Health costs DO - http://dx.doi.org/10.1111/j.1475-6773.2009.01080.x ER - TY - JOUR T1 - Food Transportation Safety: Characterizing Risks and Controls by Use of Expert Opinion AN - 754870775; 13224384 AB - Federal regulations stipulate that food products be protected against physical, chemical and microbial contamination during transportation and holding. An expert opinion elicitation was conducted to assess food safety hazards and preventive controls associated with the transportation and holding of food commodities. Frequency and severity risk rankings suggest five food safety hazards of greatest concern across all modes of transport: (1) lack of security; (2) improper holding practices for food products awaiting shipment or inspection; (3) improper temperature control; (4) cross-contamination; and (5) improper loading practices, conditions, or equipment. Factor analysis suggests that "in-transit" and "organizational" risk factors might explain the relationships among the various food safety hazards. Raw seafood, raw meat and poultry, and refrigerated raw and ready-to-eat foods have the highest overall risk (in descending order) across all modes of transit Our analysis also identified a range of preventive controls that may help eliminate/mitigate the risks to food during transport and storage, including: employee awareness and training, management review of records, and good communication between shipper, transporter and receiver. JF - Food Protection Trends AU - Ackerley, Nyssa AU - Sertkaya, Aylin AU - Lange, Rachel AD - Eastern Research Group, Inc., 110 Hartwell Ave., Lexington, MA 02421, USA; 2 Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5 1 00 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 212 PB - International Association for Food Protection, 6200 Aurora Avenue, Suite 200W Des Moines IA 50322-2864 USA VL - 30 IS - 4 SN - 1541-9576, 1541-9576 KW - Risk Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Poultry KW - Food KW - Factor analysis KW - Communication KW - Microbial contamination KW - inspection KW - Transportation KW - Risk factors KW - Chemical pollution KW - Seafood KW - Temperature effects KW - Federal regulations KW - Food contamination KW - Physical training KW - Meat KW - Communications KW - Reviews KW - A 01330:Food Microbiology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754870775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Protection+Trends&rft.atitle=Food+Transportation+Safety%3A+Characterizing+Risks+and+Controls+by+Use+of+Expert+Opinion&rft.au=Ackerley%2C+Nyssa%3BSertkaya%2C+Aylin%3BLange%2C+Rachel&rft.aulast=Ackerley&rft.aufirst=Nyssa&rft.date=2010-04-01&rft.volume=30&rft.issue=4&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Food+Protection+Trends&rft.issn=15419576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Temperature effects; Meat; Federal regulations; Poultry; Factor analysis; Risk factors; Reviews; Food; Communication; Seafood; Food contamination; Physical training; Communications; Transportation; Microbial contamination; Chemical pollution; inspection ER - TY - JOUR T1 - Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units AN - 754552185; 13310561 AB - Cyclization of bioactive peptides, utilizing functional groups serving as natural pharmacophors, is often accompanied with loss of activity. The backbone cyclization approach was developed to overcome this limitation and enhance pharmacological properties. Backbone cyclic peptides are prepared by the incorporation of special building units, capable of forming amide, disulfide and coordinative bonds. Urea bridge is often used for the preparation of cyclic peptides by connecting two amine functionalized side chains. Here we present urea backbone cyclization as an additional method for the preparation of backbone cyclic peptide libraries. A straightforward method for the synthesis of crystalline Fmoc-N [-amino(Alloc)-alkyl] glycine building units is presented. A set of urea backbone cyclic Glycogen Synthase Kinase 3 analogs was prepared and assessed for protein kinase B inhibition as anticancer leads. JF - Journal of Peptide Science AU - Hurevich, Mattan AU - Tal-Gan, Yftah AU - Klein, Shoshana AU - Barda, Yaniv AU - Levitzki, Alexander AU - Gilon, Chaim AD - Institute of Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, gilon@vms.huji.ac.il Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 178 EP - 185 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 16 IS - 4 SN - 1075-2617, 1075-2617 KW - Biotechnology and Bioengineering Abstracts KW - amines KW - Glycine KW - AKT protein KW - Urea KW - Glycogen synthase kinase 3 KW - Peptide libraries KW - amides KW - Lead KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754552185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Peptide+Science&rft.atitle=Novel+method+for+the+synthesis+of+urea+backbone+cyclic+peptides+using+new+Alloc-protected+glycine+building+units&rft.au=Hurevich%2C+Mattan%3BTal-Gan%2C+Yftah%3BKlein%2C+Shoshana%3BBarda%2C+Yaniv%3BLevitzki%2C+Alexander%3BGilon%2C+Chaim&rft.aulast=Hurevich&rft.aufirst=Mattan&rft.date=2010-04-01&rft.volume=16&rft.issue=4&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Journal+of+Peptide+Science&rft.issn=10752617&rft_id=info:doi/10.1002%2Fpsc.1218 L2 - http://www3.interscience.wiley.com/journal/123305162/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - amines; Glycine; AKT protein; Urea; Glycogen synthase kinase 3; Peptide libraries; amides; Lead DO - http://dx.doi.org/10.1002/psc.1218 ER - TY - JOUR T1 - Visual performance for trip hazard detection when using incandescent and led miner cap lamps AN - 754531720; 13211686 AB - Introduction - Accident data for 2003-2007 indicate that slip, trip, and falls (STFs) are the second leading accident class (17.8%, n = 2,441) of lost-time injuries in underground mining. Proper lighting plays a critical role in enabling miners to detect STF hazards in this environment. Often, the only lighting available to the miner is from a cap lamp worn on the miner's helmet. The focus of this research was to determine if the spectral content of light from light-emitting diode (LED) cap lamps enabled visual performance improvements for the detection of tripping hazards as compared to incandescent cap lamps that are traditionally used in underground mining. A secondary objective was to determine the effects of aging on visual performance. Method - The visual performance of 30 subjects was quantified by measuring each subject's speed and accuracy in detecting objects positioned on the floor both in the near field, at 1.83 meters, and far field, at 3.66 meters. Near field objects were positioned at 0 degrees and +/- 20 degrees off axis, while far field objects were positioned at 0 degrees and +/- 10 degrees off axis. Three age groups were designated: group A consisted of subjects 18 to 25 years old, group B consisted of subjects 40 to 50 years old, and group C consisted of subjects 51 years and older. Results - Results of the visual performance comparison for a commercially available LED, a prototype LED, and an incandescent cap lamp indicate that the location of objects on the floor, the type of cap lamp used, and subject age all had significant influences on the time required to identify potential trip hazards. The LED-based cap lamps enabled detection times that were an average of 0.96 seconds faster compared to the incandescent cap lamp. Use of the LED cap lamps resulted in average detection times that were about 13.6% faster than those recorded for the incandescent cap lamp. The visual performance differences between the commercially available LED and prototype LED cap lamp were not statistically significant. Impact on Industry - It can be inferred from this data that the spectral content from LED-based cap lamps could enable significant visual performance improvements for miners in the detection of trip hazards. JF - Journal of Safety Research AU - Sammarco, John J AU - Gallagher, Sean AU - Reyes, Miguel AD - National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, 626 Cochrans Mill Road, P.O. Box 18070, Pittsburgh, PA 15236, Jsammarco@cdc.govSgallagher@cdc.govMreyes@cdc.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 85 EP - 91 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 41 IS - 2 SN - 0022-4375, 0022-4375 KW - Health & Safety Science Abstracts KW - age groups KW - Age KW - Injuries KW - prototypes KW - Occupational safety KW - Lighting KW - Hazards KW - Accidents KW - helmets KW - Mining KW - aging KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754531720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Visual+performance+for+trip+hazard+detection+when+using+incandescent+and+led+miner+cap+lamps&rft.au=Sammarco%2C+John+J%3BGallagher%2C+Sean%3BReyes%2C+Miguel&rft.aulast=Sammarco&rft.aufirst=John&rft.date=2010-04-01&rft.volume=41&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2010.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Hazards; age groups; Age; Accidents; Injuries; prototypes; helmets; Occupational safety; Lighting; Mining; aging DO - http://dx.doi.org/10.1016/j.jsr.2010.02.007 ER - TY - JOUR T1 - A Mixed-Methods Analysis of Extramarital Sex in Contemporary China AN - 753992214; 201009813 AB - Extramarital affairs and divorce are controversial issues in China. Using a mixed-methods approach, extramarital sex (EMS) was investigated by combining statistical data about behaviors and attitudes with a textual reading of contemporary newspaper and magazine articles related to EMS in China. On the basis of the 1999-2000 Chinese Health and Family Life Survey, this study indicated that about 15% of married men and 5% of married women in China have engaged in EMS. Opportunity and permissive attitudes were related to the likelihood of engaging in EMS, especially for men. The prevalence of EMS may reflect a redistribution of power, both between and within gender groups, with Chinese men and women of higher socioeconomic status more likely to engage in EMS. Adapted from the source document. JF - Marriage & Family Review AU - Zhang, Yuanting AD - Consumer Studies Team, U.S. Food and Drug Administration, College Park, Maryland, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 170 EP - 190 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 46 IS - 3 SN - 0149-4929, 0149-4929 KW - Husbands KW - Asian Cultural Groups KW - Peoples Republic of China KW - Attitudes KW - Wives KW - Males KW - Socioeconomic Status KW - Magazines KW - Sex KW - article KW - 6143: child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753992214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marriage+%26+Family+Review&rft.atitle=A+Mixed-Methods+Analysis+of+Extramarital+Sex+in+Contemporary+China&rft.au=Zhang%2C+Yuanting&rft.aulast=Zhang&rft.aufirst=Yuanting&rft.date=2010-04-01&rft.volume=46&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Marriage+%26+Family+Review&rft.issn=01494929&rft_id=info:doi/10.1080%2F01494929.2010.490100 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-10-21 N1 - Number of references - 63 N1 - Last updated - 2016-09-28 N1 - CODEN - MFARDJ N1 - SubjectsTermNotLitGenreText - Peoples Republic of China; Asian Cultural Groups; Attitudes; Socioeconomic Status; Husbands; Magazines; Males; Wives; Sex DO - http://dx.doi.org/10.1080/01494929.2010.490100 ER - TY - RPRT T1 - Roll-Off Container Truck Driver Electrocuted When Raised Tilt Frame Contacted Overhead Line AN - 746163723; 13109894 AB - On January 18, 2008, a 45-year-old male truck driver for a roll-off container company was electrocuted when the tilt frame he had raised to load a full 40-cubic-yard roll-off container contacted energized 7,600-volt overhead power lines. He had deposited the empty 8-foot-high x 8-foot-wide x 22-foot-long roll-off container at the customer's property several days earlier. The decedent was dispatched to remove the full container from the property. He stood on the frozen ground holding the trailer's tilt frame lift controls in position to raise the tilt frame to load the full container onto the trailer. Recommendations: The employer should affix a dry non-conductive material using non-conductive insulators and fasteners at the very top of the tilt frame as a redundant safeguard prior to raising the tilt frame to prevent direct contact with an overhead line. Employers should stress hazard awareness regarding overhead power lines and routinely review the issue so that all employees are cognizant of these energized sources. Employers should train employees who work alone to conduct a jobsite survey (hazard assessment) to identify potential hazards before starting any job and to implement appropriate control measures. Equipment manufacturers should investigate the possibility of a retrofit of operating controls for boomed vehicles when designed for use from ground level to insulate the operator from the vehicle. Employers should develop, implement, and enforce a comprehensive written safety program. JF - Roll-Off Container Truck Driver Electrocuted When Raised Tilt Frame Contacted Overhead Line. [np]. Apr 2010. AU - Anonymous Y1 - 2010/04// PY - 2010 DA - Apr 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Containers KW - Reviews KW - Stress KW - Trucks KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-04-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Roll-Off+Container+Truck+Driver+Electrocuted+When+Raised+Tilt+Frame+Contacted+Overhead+Line&rft.title=Roll-Off+Container+Truck+Driver+Electrocuted+When+Raised+Tilt+Frame+Contacted+Overhead+Line&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Prediction of drug-related cardiac adverse effects in humans-B: Use of QSAR programs for early detection of drug-induced cardiac toxicities AN - 746075753; 13022171 AB - This report describes the use of three quantitative structure-activity relationship (QSAR) programs to predict drug-related cardiac adverse effects (AEs), BioEpisteme+, MC4PC, and Leadscope Predictive Data Miner. QSAR models were constructed for 9 cardiac AE clusters affecting Purkinje nerve fibers (arrhythmia, bradycardia, conduction disorder, electrocardiogram, palpitations, QT prolongation, rate rhythm composite, tachycardia, and Torsades de pointes) and 5 clusters affecting the heart muscle (coronary artery disorders, heart failure, myocardial disorders, myocardial infarction, and valve disorders). The models were based on a database of post-marketing AEs linked to 1632 chemical structures, and identical training data sets were configured for three QSAR programs. Model performance was optimized and shown to be affected by the ratio of the number of active to inactive drugs. Results revealed that the three programs were complementary and predictive performances using any single positive, consensus two positives, or consensus three positives were as follows, respectively: 70.7%, 91.7%, and 98.0% specificity; 74.7%, 47.2%, and 21.0% sensitivity; and 138.2, 206.3, and 144.2 Ie 2. In addition, a prospective study using AE data from the U.S. Food and Drug Administration's (FDA's) MedWatch Program showed 82.4% specificity and 94.3% sensitivity. Furthermore, an external validation study of 18 drugs with serious cardiotoxicity not considered in the models had 88.9% sensitivity. JF - Regulatory Toxicology and Pharmacology AU - Frid, Anna A AU - Matthews, Edwin J AD - GlobalNet Services, 11820 Parklawn Drive, Rockville, MD 20852, USA, Edwin.Matthews@fda.hhs.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 276 EP - 289 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 IS - 3 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Arrhythmia KW - USA KW - Toxicity KW - Structure-activity relationships KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746075753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Prediction+of+drug-related+cardiac+adverse+effects+in+humans-B%3A+Use+of+QSAR+programs+for+early+detection+of+drug-induced+cardiac+toxicities&rft.au=Frid%2C+Anna+A%3BMatthews%2C+Edwin+J&rft.aulast=Frid&rft.aufirst=Anna&rft.date=2010-04-01&rft.volume=56&rft.issue=3&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2009.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Structure-activity relationships; Toxicity; USA DO - http://dx.doi.org/10.1016/j.yrtph.2009.11.005 ER - TY - JOUR T1 - Prediction of drug-related cardiac adverse effects in humans--A: Creation of a database of effects and identification of factors affecting their occurrence AN - 746074096; 13022174 AB - This is the first of two reports that describes the compilation of a database of drug-related cardiac adverse effects (AEs) that was used to construct quantitative structure-activity relationship (QSAR) models to predict these AEs, to identify properties of pharmaceuticals correlated with the AEs, and to identify plausible mechanisms of action (MOAs) causing the AEs. This database of 396,985 cardiac AE reports was linked to 1632 approved drugs and their chemical structures, 1851 clinical indications (CIs), 997 therapeutic targets (TTs), 432 pharmacological MOAs, and 21,180 affinity coefficients (ACs) for the MOA receptors. AEs were obtained from the Food and Drug Administration's (FDA's) Spontaneous Reporting System (SRS) and Adverse Event Reporting System (AERS) and publicly available medical literature. Drug TTs were obtained from Integrity+; drug MOAs and ACs were predicted by BioEpisteme+. Significant cardiac AEs and patient exposures were estimated based on the proportional reporting ratios (PRRs) for each drug and each AE endpoint as a percentage of the total AEs. Cardiac AE endpoints were bundled based on toxicological mechanism and concordance of drug-related findings. Results revealed that significant cardiac AEs formed 9 clusters affecting Purkinje nerve fibers (arrhythmia, bradycardia, conduction disorder, electrocardiogram, palpitations, QT prolongation, rate rhythm composite, tachycardia, and Torsades de pointes), and 5 clusters affecting the heart muscle (coronary artery disorders, heart failure, myocardial disorders, myocardial infarction, and valve disorders). Based on the observation that each drug had one TT and up to 9 off-target MOAs, cardiac AEs were highly correlated with drugs affecting cardiovascular and cardioneurological functions and certain MOAs (e.g., alpha- and beta-adeno, dopamine, and hydroxytryptomine receptors). JF - Regulatory Toxicology and Pharmacology AU - Matthews, Edwin J AU - Frid, Anna A AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety (OFAS), 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 247 EP - 275 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 IS - 3 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Toxicology Abstracts KW - Arrhythmia KW - Drugs KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746074096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Prediction+of+drug-related+cardiac+adverse+effects+in+humans--A%3A+Creation+of+a+database+of+effects+and+identification+of+factors+affecting+their+occurrence&rft.au=Matthews%2C+Edwin+J%3BFrid%2C+Anna+A&rft.aulast=Matthews&rft.aufirst=Edwin&rft.date=2010-04-01&rft.volume=56&rft.issue=3&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2009.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drugs DO - http://dx.doi.org/10.1016/j.yrtph.2009.11.006 ER - TY - JOUR T1 - Surgical mask placement over N95 filtering facepiece respirators: Physiological effects on healthcare workers AN - 746072374; 12796655 AB - ABSTRACTTen healthcare workers wearing N95 filtering facepiece respirators with, and without, a surgical mask outer covering were physiologically monitored. No significant differences in heart rate, breathing rate, tidal volume, minute volume, transcutaneous carbon dioxide and oxygen saturation were observed with application of the surgical mask.Background and objective: Filtering facepiece respirators ('N95 Masks') may be in short supply during large-scale infectious outbreaks. Suggestions have been made to extend their useful life by using a surgical mask as an outer barrier, but the physiological impact of this added barrier upon the wearer has not been studied.Methods: A surgical mask was worn over an N95 filtering facepiece respirator by 10 healthcare workers for 1 h at each of two work rates. Heart rate, respiratory rate, tidal volume, minute volume, oxygen saturation, transcutaneous carbon dioxide levels and respirator dead space gases were monitored and compared with controls (N95 filtering facepiece respirator without a surgical mask). Subjective perceptions of exertion and comfort were assessed by numerical rating scales.Results: There were no significant differences in physiological variables between those who used surgical masks and controls. Surgical masks decreased dead space oxygen concentrations of the filtering facepiece respirators at the lesser work rate (P = 0.03) and for filtering facepiece respirators with an exhalation valve at the higher work rate (P = 0.003). Respirator dead space oxygen and carbon dioxide levels were not harmonious with Occupational Safety and Health Administration workplace ambient atmosphere standards. Exertion and comfort scores were not significantly impacted by the surgical mask.Conclusions: Use of a surgical mask as an outer barrier over N95 filtering facepiece respirators does not significantly impact the physiological burden or perceptions of comfort and exertion by the wearer over that experienced without use of a surgical mask. JF - Respirology AU - ROBERGE, Raymond J AU - COCA, Aitor AU - WILLIAMS, WJon AU - PALMIERO, Andrew J AU - POWELL, Jeffrey B AD - 1National Personal Protective Technology Laboratory/National Institute for Occupational Safety and Health, and Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 516 EP - 521 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 15 IS - 3 SN - 1323-7799, 1323-7799 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746072374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respirology&rft.atitle=Surgical+mask+placement+over+N95+filtering+facepiece+respirators%3A+Physiological+effects+on+healthcare+workers&rft.au=ROBERGE%2C+Raymond+J%3BCOCA%2C+Aitor%3BWILLIAMS%2C+WJon%3BPALMIERO%2C+Andrew+J%3BPOWELL%2C+Jeffrey+B&rft.aulast=ROBERGE&rft.aufirst=Raymond&rft.date=2010-04-01&rft.volume=15&rft.issue=3&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Respirology&rft.issn=13237799&rft_id=info:doi/10.1111%2Fj.1440-1843.2010.01713.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1111/j.1440-1843.2010.01713.x ER - TY - JOUR T1 - Associations Between Duration of Illicit Drug Use and Health Conditions: Results from the 2005-2007 National Surveys on Drug Use and Health AN - 746009024; 13042908 AB - Purpose - To estimate and compare prevalence rates of lifetime health conditions by inferred duration of illicit drug use among the general U.S. adult population and to investigate associations between duration of use of each specific illicit drug (marijuana, cocaine, heroin, hallucinogens, or inhalant) and each lifetime health condition after controlling for potential confounding factors. Methods - Data from respondents aged 35 to 49 (N = 29,195) from the 2005-2007 National Surveys on Drug Use and Health (NSDUH) were analyzed. Results - The prevalence rates of a broad range of health conditions by duration of use of specific illicit drug among persons 35 to 49 years of age in the United States were estimated and compared. After adjustment for potential confounding factors, the results of 20 multivariate logistic regression models indicated positive associations between duration of marijuana use and anxiety, depression, sexually transmitted disease (STD), bronchitis, and lung cancer; between duration of cocaine use and anxiety and pancreatitis; between duration of heroin use and anxiety, hepatitis, and tuberculosis; between duration of hallucinogen use and tinnitus and STD; and between duration of inhalant use and anxiety, depression, HIV/AIDS, STD, tuberculosis, bronchitis, asthma, sinusitis, and tinnitus. Conclusions - This study provides initial analyses on the relationships between illicit drug use and health conditions based on a large nationally representative sample. These results can help prepare for treating health problems among former and continuing illicit drug users. JF - Annals of Epidemiology AU - Han, Beth AU - Gfroerer, Joseph C AU - Colliver, James D AD - Office of Applied Studies, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Rockville,, beth.han@samhsa.hhs.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 289 EP - 297 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 20 IS - 4 SN - 1047-2797, 1047-2797 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Acquired immune deficiency syndrome KW - USA KW - Human immunodeficiency virus KW - Drug abuse KW - H 11000:Diseases/Injuries/Trauma KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746009024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Associations+Between+Duration+of+Illicit+Drug+Use+and+Health+Conditions%3A+Results+from+the+2005-2007+National+Surveys+on+Drug+Use+and+Health&rft.au=Han%2C+Beth%3BGfroerer%2C+Joseph+C%3BColliver%2C+James+D&rft.aulast=Han&rft.aufirst=Beth&rft.date=2010-04-01&rft.volume=20&rft.issue=4&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2010.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drug abuse; Human immunodeficiency virus; USA DO - http://dx.doi.org/10.1016/j.annepidem.2010.01.003 ER - TY - JOUR T1 - A versatile internal control for use as DNA in real-time PCR and as RNA in real-time reverse transcription PCR assays AN - 746001060; 12778186 AB - To develop and evaluate a TaqMan-based internal amplification control (IAC) that can be used as DNA in real-time PCR (qPCR) or as RNA in reverse transcription real-time PCR (qRT-PCR) to identify the presence of assay inhibition and to evaluate its incorporation into existing qPCR and qRT-PCR methods for bacterial detection.Methods and Results: A DNA IAC was constructed by generating a 198-bp random sequence that was synthesized and inserted into a pZErO-2 vector and transformed into Escherichia coli. The RNA IAC was generated through in vitro transcription of the DNA IAC. Both IAC formats were tested individually in singleplex TaqMan reactions and also included in existing multiplex assays. The DNA IAC was incorporated in a Shigella spp. detection qPCR assay (targeting ipaH). The RNA IAC was successfully evaluated in a Salmonella spp. detection qRT-PCR (using invA mRNA as target).Conclusions: A highly versatile IAC that can be supplemented to qPCR and qRT-PCR pathogen detection methods was developed, greatly reducing the confounding effects of false negatives because of PCR inhibitors without affecting pathogen detection.Significance and Impact of the Study: The frequency of false negatives associated with qPCR analyses is prevalent in certain matrices, particularly those involving complex foods. Hence, the IAC presented here provides a solution to unforeseen false-negative reactions in PCR. JF - Letters in Applied Microbiology AU - Deer, D M AU - Lampel, KA AU - Gonzalez-Escalona, N AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA, narjol.gonzalez-escalona@fda.hhs.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 366 EP - 372 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 50 IS - 4 SN - 0266-8254, 0266-8254 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology KW - internal control KW - PCR KW - real-time PCR KW - reverse transcription PCR KW - Food KW - Nucleotide sequence KW - Transcription KW - Shigella KW - Pathogens KW - Reverse transcription KW - RNA KW - Microbiology KW - Escherichia coli KW - DNA KW - Polymerase chain reaction KW - Disease detection KW - Salmonella KW - Nucleic acids KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - N 14810:Methods KW - A 01300:Methods KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746001060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Letters+in+Applied+Microbiology&rft.atitle=A+versatile+internal+control+for+use+as+DNA+in+real-time+PCR+and+as+RNA+in+real-time+reverse+transcription+PCR+assays&rft.au=Deer%2C+D+M%3BLampel%2C+KA%3BGonzalez-Escalona%2C+N&rft.aulast=Deer&rft.aufirst=D&rft.date=2010-04-01&rft.volume=50&rft.issue=4&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Letters+in+Applied+Microbiology&rft.issn=02668254&rft_id=info:doi/10.1111%2Fj.1472-765X.2010.02804.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Number of references - 18 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - RNA; Nucleotide sequence; Microbiology; DNA; Transcription; Polymerase chain reaction; Disease detection; Pathogens; Nucleic acids; Food; Reverse transcription; Escherichia coli; Shigella; Salmonella DO - http://dx.doi.org/10.1111/j.1472-765X.2010.02804.x ER - TY - JOUR T1 - Self-reported Health, Functional Status and Chronic Disease in Community Dwelling Older Adults: Untangling the Role of Demographics AN - 745929496; 12594031 AB - Self-reported health, a widely used measure of general health status in population studies, can be affected by certain demographic variables such as gender, race/ethnicity and education. This cross-sectional assessment of the current health status of older adult residents was conducted in an inner-city Houston neighborhood in May, 2007. A survey instrument, with questions on chronic disease prevalence, health limitations/functional status, self-reported subjective health status in addition to demographic data on households was administered to a systematic random sample of residents. Older adults (>60years of age) were interviewed (weighted N=127) at their homes by trained interviewers. The results indicated that these residents, with low literacy levels, low household income and a high prevalence of frequently reported chronic diseases (hypertension, diabetes and arthritis) also reported non-participation in community activities, volunteerism and activities centered on organized religion, thus, potentially placing them at risk for social isolation. Women reported poorer self-reported health and appeared to fare worse in all health limitation indicators and reported greater structural barriers in involvement with their community. Blacks reported worse health outcomes on all indicators than other sub-groups, an indication that skills training in chronic disease self-management and in actively eliciting support from various sources may be beneficial for this group. Therefore, the use of self-reported health with a broad brush as an indicator of 'true' population health status is not advisable. Sufficient consideration should be given to the racial/ethnic and gender differences and these should be accounted for. JF - Journal of Community Health AU - Banerjee, Deborah AU - Perry, Mark AU - Tran, Dinh AU - Arafat, Raouf AD - Houston Department of Health and Human Services, Community Health Statistics, 8000 N. Stadium Drive, 8th Floor, Houston, TX, 77054, USA, deborah.banerjee@cityofhouston.net Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 135 EP - 141 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 35 IS - 2 SN - 0094-5145, 0094-5145 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Risk Abstracts KW - demography KW - Age KW - Data processing KW - Training KW - Population studies KW - Sex differences KW - Social interactions KW - population studies KW - Demography KW - Diabetes mellitus KW - households KW - Education KW - diabetes mellitus KW - income KW - Arthritis KW - Gender KW - hypertension KW - USA, Texas, Houston KW - Ethnic groups KW - Races KW - Hypertension KW - A 01450:Environmental Pollution & Waste Treatment KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745929496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Self-reported+Health%2C+Functional+Status+and+Chronic+Disease+in+Community+Dwelling+Older+Adults%3A+Untangling+the+Role+of+Demographics&rft.au=Banerjee%2C+Deborah%3BPerry%2C+Mark%3BTran%2C+Dinh%3BArafat%2C+Raouf&rft.aulast=Banerjee&rft.aufirst=Deborah&rft.date=2010-04-01&rft.volume=35&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-009-9208-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Demography; Age; Data processing; Arthritis; Population studies; Sex differences; Races; Ethnic groups; Social interactions; Hypertension; population studies; demography; diabetes mellitus; Education; households; Training; income; hypertension; Gender; USA, Texas, Houston DO - http://dx.doi.org/10.1007/s10900-009-9208-y ER - TY - JOUR T1 - Detection and characterization of human parechoviruses in archived cell cultures, in Hungary AN - 745928771; 13023812 AB - Human parechoviruses (HPeV) belonging to the family Picornaviridae are widespread enteric pathogens and associated with various clinical symptoms in humans. There is no report for detection of the circulating parechoviruses in Central Europe. The aim of this retrospective study was to detect and characterize human parechoviruses in cell cultures with "enterovirus"-like cytophatic effect (CPE) archived between 1990 and 2000, in Hungary. Fecal samples from children with symptoms of gastroenteritis under age of 10 were cultured as a previous routine diagnostic laboratory protocol for "enterovirus". Cell cultures indicating CPE were archived and deeply chilled (a80AC) from minimum 2 individuals (2-12 patients) in each year. Specimens were tested retrospectively, in 2009, for HPeV by reverse transcription-PCR (RT-PCR) method using 5a super(2)UTR conserved primers. Specific primer pairs were designed to determine the complete nucleotide sequence of the structural region (VP0-VP3-VP1) of HPeV. Nine (9.1%) of 66 archived samples were found to be HPeV-positive. Six (67%) samples were identified as HPeV1, 2 (22%) were HPeV4 and 1 could not be determined. Three HPeV1 clusters were identified according to the isolation date originated from years 1990/1991, 1992/1995 and 1998. This is the first detection of human parechoviruses in Central Europe. Detection and genetic characterization of HPeV in available historical samples infected with previously unidentifiable agents with "enterovirus-like" cytopathogenic effect help to understand the genetic diversity and evolution of these viruses. JF - Journal of Clinical Virology AU - Boros, Akos AU - Asj, Maria AU - Pankovics, Peter AU - Reuter, Gabor AD - Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, H-7623 Szabadsag ut 7, Pecs, Hungary, reuter.gabor@ddr.antsz.hu Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 379 EP - 381 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 47 IS - 4 SN - 1386-6532, 1386-6532 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Age KW - Picornaviridae KW - Cell culture KW - W 30945:Fermentation & Cell Culture KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Detection+and+characterization+of+human+parechoviruses+in+archived+cell+cultures%2C+in+Hungary&rft.au=Boros%2C+Akos%3BAsj%2C+Maria%3BPankovics%2C+Peter%3BReuter%2C+Gabor&rft.aulast=Boros&rft.aufirst=Akos&rft.date=2010-04-01&rft.volume=47&rft.issue=4&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2010.01.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Cell culture; Picornaviridae DO - http://dx.doi.org/10.1016/j.jcv.2010.01.012 ER - TY - JOUR T1 - Chlamydia trachomatis in Tasmania 2001--2007: rising notification trends AN - 745903454; 12743123 AB - Objectives: To investigate trends in notification rates of Chlamydia trachomatis in Tasmania, Australia, by population sub-groups, from 1 January 2001 to 31 December 2007. Methods: An enhanced surveillance dataset was used to supplement case notifications. Rates based on age group were analysed by sex, geographic region, indigenous status, sexual exposure, reason for testing and healthcare provider. Results: In all age groups, the notification rate increased steeply. The highest rates were seen in the ages 15--24 years; this age group represented 15% of the population but accounted for 74% of the chlamydial notifications. The increased rates in females aged 15--24 years and males 15--19 years in Tasmania were larger than the increases observed nationally. Rates were consistently higher in urban areas. Females were more likely to have been tested as a result of screening, and males were more likely to have been tested when presenting with symptoms or as a result of contact tracing. The majority of cases reported sexual exposure with opposite sex partners only. Conclusions: This study highlights the increasing significance of chlamydial infection as a public health issue, the gender differences in health-seeking behaviour, and the discrepancies in testing patterns. These findings will assist with the design of health promotion programs. Submitted: April 2009 Revision requested: August 2009 Accepted: October 2009. JF - Australian and New Zealand Journal of Public Health AU - Stephens, Nicola AU - O'Sullivan, Maree AU - Coleman, David AU - Shaw, Kelly AD - Communicable Diseases Prevention Unit, Department of Health and Human Services, Tasmania., nicola.stephens@dhhs.tas.gov.au Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 120 EP - 125 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 34 IS - 2 SN - 1326-0200, 1326-0200 KW - Microbiology Abstracts B: Bacteriology KW - Age KW - Chlamydia trachomatis KW - Infection KW - Contact tracing KW - Sex differences KW - Sex KW - Public health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745903454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Australian+and+New+Zealand+Journal+of+Public+Health&rft.atitle=Chlamydia+trachomatis+in+Tasmania+2001--2007%3A+rising+notification+trends&rft.au=Stephens%2C+Nicola%3BO%27Sullivan%2C+Maree%3BColeman%2C+David%3BShaw%2C+Kelly&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2010-04-01&rft.volume=34&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Australian+and+New+Zealand+Journal+of+Public+Health&rft.issn=13260200&rft_id=info:doi/10.1111%2Fj.1753-6405.2010.00494.x L2 - http://www3.interscience.wiley.com/journal/123344440/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; Sex differences; Contact tracing; Infection; Public health; Sex; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1753-6405.2010.00494.x ER - TY - JOUR T1 - A structural feature-based computational approach for toxicology predictions AN - 745609754; 12689869 AB - Importance of the field: Evaluation of pharmaceutical-related toxicities using quantitative structure-activity relationship (QSAR) software as decision support tools is becoming practical and is of keen interest to scientists in both product safety and discovery. QSARs can be used to predict preclinical and clinical endpoints, drug metabolism, pharmacokinetics and mechanisms responsible for toxicity. These in silico tools are of interest in supporting regulatory review processes, and priority setting in research and product development. Areas covered in this review: A critical assessment of the current capabilities of a new technology, the Leadscope Model Applier, is presented. Possible strengths and limitations of this technology with emphasis on the chemoinformatics method are described, and supporting literature citations date back to 1983. What the reader will gain: Insight will be gained into the Leadscope Model Applier technology for structural feature-based QSAR models and its potential capability for chemical inference if the training sets are transparently open. Currently, however, there is a lack of transparency due to the protection of the proprietary training set. Take home message: Further research and development is needed in the creation of more stringently validated models with greater transparency and better balance between sensitivity and specificity. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Valerio, Luis G AU - Yang, Chihae AU - Arvidson, Kirk B AU - Kruhlak, Naomi L AD - 1Informatics and Computational Safety Analysis Staff, Science and Research Staff, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002 Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 505 EP - 518 PB - Informa Healthcare VL - 6 IS - 4 SN - 1742-5255, 1742-5255 KW - Toxicology Abstracts KW - Computer programs KW - software KW - Reviews KW - Drug metabolism KW - Toxicity KW - Computer applications KW - Structure-activity relationships KW - Pharmacokinetics KW - Models KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745609754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=A+structural+feature-based+computational+approach+for+toxicology+predictions&rft.au=Valerio%2C+Luis+G%3BYang%2C+Chihae%3BArvidson%2C+Kirk+B%3BKruhlak%2C+Naomi+L&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-04-01&rft.volume=6&rft.issue=4&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425250903499286 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Drug metabolism; Reviews; Toxicity; Computer applications; Structure-activity relationships; Pharmacokinetics; Models DO - http://dx.doi.org/10.1517/17425250903499286 ER - TY - JOUR T1 - Rapid Detection and Suppression of Mining Equipment Cab Fires AN - 744674138; 12596643 AB - The National Institute for Occupational Safety and Health (NIOSH/PRL) conducted a series of large-scale experiments to evaluate the effectiveness of optical flame detectors, photoelectric smoke detectors, and combined ionization and photoelectric smoke detectors for rapidly detecting mining equipment cab fires. The detector alarm times were then used to trigger the discharge of a fire inerting system inside the cab to suppress cab material fires. This paper discusses the types of fire detectors tested, the experiments that were conducted, and the results that were obtained. Conclusions are that rapid detection of equipment cab fires can be achieved to trigger the discharge of a fire inerting system inside the cab to protect the operator in the cab. JF - Fire Technology AU - Rosa, Maria I AU - Litton, Charles D AD - Pittsburgh Research Laboratory, National Institute for Occupational Safety and Health, P.O. Box 18070, Pittsburgh, PA, 15236, USA, MGD8@cdc.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 425 EP - 435 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 46 IS - 2 SN - 0015-2684, 0015-2684 KW - Health & Safety Science Abstracts KW - Smoke KW - Fires KW - mining equipment KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744674138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fire+Technology&rft.atitle=Rapid+Detection+and+Suppression+of+Mining+Equipment+Cab+Fires&rft.au=Rosa%2C+Maria+I%3BLitton%2C+Charles+D&rft.aulast=Rosa&rft.aufirst=Maria&rft.date=2010-04-01&rft.volume=46&rft.issue=2&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Fire+Technology&rft.issn=00152684&rft_id=info:doi/10.1007%2Fs10694-007-0022-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Smoke; mining equipment; Fires; Occupational safety DO - http://dx.doi.org/10.1007/s10694-007-0022-8 ER - TY - JOUR T1 - Sudan azo dyes and Para Red degradation by prevalent bacteria of the human gastrointestinal tract AN - 744616874; 13004883 AB - Sudan azo dyes have genotoxic effects and ingestion of food products contaminated with Sudan I, IV, and Para Red could lead to exposure in the human gastrointestinal tract. In this study, we examined thirty-five prevalent species of human intestinal bacteria to evaluate their capacity to degrade Sudan dyes and Para Red. Among these tested bacterial strains, 23, 13, 33, 30, and 29 out of 35 species tested were able to reduce Sudan I, IV, and Para Red, respectively, to some extent. Bifidobacterium infantis, Clostridium indolis, Enterococcus faecalis, Lactobacillus rhamnosus, and Ruminococcus obeum were able to reduce completely all four tested Sudan dyes and Para Red. Escherichia coli and Peptostreptococcus magnus were the only two strains that were not able to reduce any of the tested Sudan dyes and Para Red to any significant extent. Metabolites of the reduction of the tested Sudan dyes and Para Red by E. faecalis were isolated and identified by HPLC and LC/ESI-MS analyses and compared with authentic standards. Thus it appears that the ability to reduce Sudan dyes and Para Red except Sudan II is common among bacteria in the human colon. JF - Anaerobe AU - Xu, Haiyan AU - Heinze, Thomas M AU - Paine, Donald D AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-9502, USA, huizhong.chen@fda.hhs.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 114 EP - 119 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 16 IS - 2 SN - 1075-9964, 1075-9964 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Azo dyes KW - Bifidobacterium infantis KW - Dyes KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744616874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Sudan+azo+dyes+and+Para+Red+degradation+by+prevalent+bacteria+of+the+human+gastrointestinal+tract&rft.au=Xu%2C+Haiyan%3BHeinze%2C+Thomas+M%3BPaine%2C+Donald+D%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Xu&rft.aufirst=Haiyan&rft.date=2010-04-01&rft.volume=16&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=10759964&rft_id=info:doi/10.1016%2Fj.anaerobe.2009.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Dyes; Bifidobacterium infantis DO - http://dx.doi.org/10.1016/j.anaerobe.2009.06.007 ER - TY - JOUR T1 - Using proxy measures and other correlates of survey outcomes to adjust for non-response: examples from multiple surveys AN - 743813977; 3980214 AB - Non-response weighting is a commonly used method to adjust for bias due to unit non-response in surveys. Theory and simulations show that, to reduce bias effectively without increasing variance, a covariate that is used for non-response weighting adjustment needs to be highly associated with both the response indicator and the survey outcome variable. In practice, these requirements pose a challenge that is often overlooked, because those covariates are often not observed or may not exist. Surveys have recently begun to collect supplementary data, such as interviewer observations and other proxy measures of key survey outcome variables. To the extent that these auxiliary variables are highly correlated with the actual outcomes, these variables are promising candidates for non-response adjustment. In the present study, we examine traditional covariates and new auxiliary variables for the National Survey of Family Growth, the Medical Expenditure Panel Survey, the American National Election Survey, the European Social Surveys and the University of Michigan Transportation Research Institute survey. We provide empirical estimates of the association between proxy measures and response to the survey request as well as the actual survey outcome variables. We also compare unweighted and weighted estimates under various non-response models. Our results from multiple surveys with multiple recruitment protocols from multiple organizations on multiple topics show the difficulty of finding suitable covariates for non-response adjustment and the need to improve the quality of auxiliary data. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Kreuter, F AU - Olson, K AU - Wagner, J AU - Yan, T AU - Ezzati-Rice, T M AU - Casas-Cordero, C AU - Lemay, M AU - Peytchev, A AU - Groves, R M AU - Raghunathan, T E AD - University of Maryland ; University of Nebraska ; University of Michigan ; National Opinion Research Center, Chicago ; Agency for Healthcare Research and Quality, Rockville ; RTI International Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 389 EP - 408 VL - 173 IS - 2 SN - 0964-1998, 0964-1998 KW - Economics KW - Comparative analysis KW - Measurement KW - Simulation KW - Surveys KW - Estimation KW - Statistical methods KW - Covariance KW - Bias KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743813977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Using+proxy+measures+and+other+correlates+of+survey+outcomes+to+adjust+for+non-response%3A+examples+from+multiple+surveys&rft.au=Kreuter%2C+F%3BOlson%2C+K%3BWagner%2C+J%3BYan%2C+T%3BEzzati-Rice%2C+T+M%3BCasas-Cordero%2C+C%3BLemay%2C+M%3BPeytchev%2C+A%3BGroves%2C+R+M%3BRaghunathan%2C+T+E&rft.aulast=Kreuter&rft.aufirst=F&rft.date=2010-04-01&rft.volume=173&rft.issue=2&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=09641998&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12429; 1565 1362 2688 2449 10404; 7994; 11670; 2977 13249 10214 12224 971; 7854; 12228 10919; 4403 7854; 2630 971 ER - TY - JOUR T1 - Is Veteran Status and Suicide Risk Assessed in Community Long-Term Care? A Review of the States' Assessment Instruments AN - 743045756; 201034420 AB - Given recent policy initiatives to address suicide risk among older persons and veterans, community-based elder serving agencies may serve an important role in identifying and referring individuals at risk for suicide. A review of state-level long-term assessment instruments was conducted to determine whether veteran status and suicide are assessed. Data from forty-three state's Units on Aging instruments were content analyzed. Results indicate that over two thirds of the states in this review included questions about suicide and veterans in their assessments, 69.8% and 67.4% respectively. Suicide risk among elders and veterans must be addressed at local, state, and federal levels so that concerted attention and oversight can be provided for matching elders to the services they need. Adapted from the source document. JF - Suicide and Life-Threatening Behavior AU - Matthieu, Monica M AU - Welch, Benjamin AU - Morrow-Howell, Nancy AU - Proctor, Enola AU - Nickel, Michael AU - Navarro, Jessica AU - Moon, Alyson AD - Center for Mental Health Services Research, George Warren Brown School of Social Work, Washington University in St. Louis, Campus Box 1196, St. Louis, MO 63130 mmatthieu@wustl.edu Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 125 EP - 132 PB - Guilford Publications, New York NY VL - 40 IS - 2 SN - 0363-0234, 0363-0234 KW - Veterans KW - Risk KW - Aging KW - Elderly KW - Long Term Care KW - Suicide KW - article KW - 2046: sociology of health and medicine; social psychiatry (mental health) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743045756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Suicide+and+Life-Threatening+Behavior&rft.atitle=Is+Veteran+Status+and+Suicide+Risk+Assessed+in+Community+Long-Term+Care%3F+A+Review+of+the+States%27+Assessment+Instruments&rft.au=Matthieu%2C+Monica+M%3BWelch%2C+Benjamin%3BMorrow-Howell%2C+Nancy%3BProctor%2C+Enola%3BNickel%2C+Michael%3BNavarro%2C+Jessica%3BMoon%2C+Alyson&rft.aulast=Matthieu&rft.aufirst=Monica&rft.date=2010-04-01&rft.volume=40&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Suicide+and+Life-Threatening+Behavior&rft.issn=03630234&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2010-06-07 N1 - Number of references - 13 N1 - Last updated - 2016-09-28 N1 - CODEN - SLBEDP N1 - SubjectsTermNotLitGenreText - Suicide; Veterans; Elderly; Risk; Long Term Care; Aging ER - TY - JOUR T1 - A Partisan Divide On The Uninsured AN - 742956227; 2010-522113 AB - The partisan split in Congress over health reform may reflect a broader divide among the public in attitudes toward the uninsured. Despite expert consensus over the harms suffered by the uninsured as a group, Americans disagree over whether the uninsured get the care they need and whether reform legislation providing universal coverage is necessary. We examined public perceptions of health care access and quality for the uninsured over time, and we found that Democrats are far more likely than Republicans to believe that the uninsured have difficulty gaining access to care. Senior citizens are less aware than others of the problems faced by the uninsured. Even among those Americans who perceive that the uninsured have poor access to care, Republicans are significantly less likely than Democrats to support reform. Thus, our findings indicate that even if political obstacles are overcome and health reform is enacted, future political support for ongoing financing to cover the uninsured could be uncertain. Adapted from the source document. JF - Health Affairs AU - Oakman, Tara Sussman AU - Blendon, Robert J AU - Campbell, Andrea L AU - Zaslavsky, Alan M AU - Benson, John M AD - U.S. Department of Health and Human Services, in Washington, D.C Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 706 EP - 711 PB - Project HOPE, Bethesda MD VL - 29 IS - 4 SN - 0278-2715, 0278-2715 KW - Business and service sector - Insurance KW - Health conditions and policy - Health and health policy KW - Health conditions and policy - Medicine and health care KW - Law and ethics - Law and jurisprudence KW - Politics - Political ideologies and movements KW - Politics - Political parties and groups KW - United States KW - Uninsured persons KW - Health policy KW - Right and Left KW - Government and politics KW - Medical service KW - Legislation KW - Political parties KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742956227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=A+Partisan+Divide+On+The+Uninsured&rft.au=Oakman%2C+Tara+Sussman%3BBlendon%2C+Robert+J%3BCampbell%2C+Andrea+L%3BZaslavsky%2C+Alan+M%3BBenson%2C+John+M&rft.aulast=Oakman&rft.aufirst=Tara&rft.date=2010-04-01&rft.volume=29&rft.issue=4&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2009.1019 LA - English DB - PAIS Index N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Right and Left; Political parties; Uninsured persons; Government and politics; United States; Health policy; Medical service; Legislation DO - http://dx.doi.org/10.1377/hlthaff.2009.1019 ER - TY - JOUR T1 - Reduction of smoking in Dutch adolescents over the past decade and its health gains: a repeated cross-sectional study AN - 742954480; 2010-538588 AB - Background: Smoking is the main preventable lifestyle-related risk factor threatening human health. In this study, time trends in smoking behaviour between 1996 and 2005 among adolescents enrolled in secondary school were assessed. Methods: In 1996, 2001 and 2005, a survey was conducted in the south-eastern region of the Netherlands. All students in second and fourth year of secondary education (1996: n = 20000; 2001: n = 27500; 2005: n = 24000) were asked to complete a questionnaire about their smoking behaviour. A simulation model was used to estimate lifetime health gains related to the observed trends. Results: In 1996, 2001 and 2005, the number of questionnaires analysed were 13554(68%), 20767 (76%) and 17896 (75%), respectively. The results show a decrease in 'ever smoking' as well as 'current smoking' between 1996 and 2005. Among second year high school students, current smoking prevalence decreased from 22.2% in 1996 to 8.0% in 2005 (Ptrend<0.001). Among fourth year students, current smoking declined from 37.5% in 1996 to 22.0% in 2005 (Ptrend<0.001). Time trends were not influenced by gender or educational level. Model projections show that if these students not take up smoking later in life, 11 500 new cases of COPD, 3400 new cases of lung cancer and 1800 new cases of myocardial infarction could be prevented for the Dutch 13-year-olds. Conclusion: This study found that, in the past decade, smoking prevalence among adolescents has declined by almost 50%, potentially resulting in a considerable reduction in new cases of COPD or lung cancer. Adapted from the source document. JF - European Journal of Public Health AU - Gielkens-Sijstermans, Cindy M AU - Mommers, Monique A AU - Hoogenveen, Rudolf T AU - Feenstra, Talitha L AU - de Vreede, Jacqueline AU - Bovens, Fons M AU - van Schayck, Onno C AD - South Limburg Public Health Service, P.O. Box 2022, 6160 HA Geleen, the Netherlands, tel: +31 46 850 54 52, fax: +31 46 850 66 67 Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 146 EP - 150 PB - Oxford University Press. UK VL - 20 IS - 2 SN - 1101-1262, 1101-1262 KW - Population groups, population policy, and demographics - Children and youth KW - Health conditions and policy - Health and health policy KW - Social conditions and policy - Drinking, smoking, and drug addiction KW - Education and education policy - Education personnel and population KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Medicine and health care KW - Education and education policy - Schools KW - adolescents, health, smoking KW - High school students KW - Risk KW - Smoking KW - Schools KW - Public health education KW - Netherlands KW - Students KW - Youth KW - Lung cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742954480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Public+Health&rft.atitle=Reduction+of+smoking+in+Dutch+adolescents+over+the+past+decade+and+its+health+gains%3A+a+repeated+cross-sectional+study&rft.au=Gielkens-Sijstermans%2C+Cindy+M%3BMommers%2C+Monique+A%3BHoogenveen%2C+Rudolf+T%3BFeenstra%2C+Talitha+L%3Bde+Vreede%2C+Jacqueline%3BBovens%2C+Fons+M%3Bvan+Schayck%2C+Onno+C&rft.aulast=Gielkens-Sijstermans&rft.aufirst=Cindy&rft.date=2010-04-01&rft.volume=20&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Public+Health&rft.issn=11011262&rft_id=info:doi/10.1093%2Feurpub%2Fckp115 LA - English DB - PAIS Index N1 - Date revised - 2010-06-07 N1 - Last updated - 2016-09-28 N1 - CODEN - EJPHF6 N1 - SubjectsTermNotLitGenreText - Youth; Public health education; Smoking; Students; Netherlands; Lung cancer; High school students; Risk; Schools DO - http://dx.doi.org/10.1093/eurpub/ckp115 ER - TY - JOUR T1 - Evolution of clinical trials for irritable bowel syndrome: issues in end points and study design. AN - 742786511; pmid-20372121 AB - Irritable bowel syndrome (IBS) involves a broad range of physiological and psychological alterations that may affect brain-gut dysregulation, gut function, visceral perception, and mucosal integrity and function. Despite advances in our understanding of basic neuroenteric mechanisms and the role of effectors and transmitters in the brain-gut axis, a reliable biologic marker of IBS has yet to be identified. IBS diagnosis and status depend entirely on an assessment of IBS signs and symptoms. This has made development of optimal end points and study design for evaluation of efficacy of IBS drugs a challenge. This article addresses three main topics: the evolution of primary end points for IBS clinical trials; a potential path forward for IBS end points in new clinical trials; and recommendations for the future development of patient-reported outcome (PRO) instruments for use in IBS clinical trials. JF - The American journal of gastroenterology AU - Trentacosti, Ann Marie AU - He, Ruyi AU - Burke, Laurie B AU - Griebel, Donna AU - Kennedy, Dianne L AD - Study Endpoints and Labeling Development, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA. annmarie.trentacost@fda.hhs.gov Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 731 EP - 735 VL - 105 IS - 4 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - United States KW - United States Food and Drug Administration KW - Irritable Bowel Syndrome -- therapy KW - Humans KW - Treatment Outcome KW - Guidelines as Topic KW - Irritable Bowel Syndrome -- diagnosis KW - Clinical Trials as Topic KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742786511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Evolution+of+clinical+trials+for+irritable+bowel+syndrome%3A+issues+in+end+points+and+study+design.&rft.au=Trentacosti%2C+Ann+Marie%3BHe%2C+Ruyi%3BBurke%2C+Laurie+B%3BGriebel%2C+Donna%3BKennedy%2C+Dianne+L&rft.aulast=Trentacosti&rft.aufirst=Ann&rft.date=2010-04-01&rft.volume=105&rft.issue=4&rft.spage=731&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2010-05-19 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Mental Health and Family Out-of-Pocket Expenditure Burdens AN - 742723246; 201012575 AB - A growing literature finds that a significant fraction of American families experience high or 'catastrophic' burdens of medical spending. Families facing mental health problems may be especially vulnerable to high burdens. This study uses data from the Medical Expenditure Panel Survey to determine the annual and within-year concentration of medical spending and the extent to which mental health treatment contributes to high out-of-pocket burdens among families with and without mental health problems. On average, families incurred 44% of non--mental health and 37% of out-of-pocket mental health treatment expenditures in a single month. Families with one or more members experiencing mental health problems were more likely to have periods of high out-of-pocket spending burdens. However, this study found that mental health treatment itself contributes little to high out-of-pocket spending burdens. Most of the burden was due to other medical conditions and lower average incomes among families with mental health problems. [Copyright Sage Publications, Inc.] JF - Medical Care Research and Review AU - Zuvekas, Samuel H AU - Selden, Thomas M AD - Agency for Healthcare Research and Quality, Rockville, MD zuvekas@ahrq.hhs.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 194 EP - 212 PB - Sage Publications, Thousand Oaks CA VL - 67 IS - 2 SN - 1077-5587, 1077-5587 KW - medical utilization mental health expenditures burdens KW - Health costs KW - Personal expenditure KW - Mental health services KW - Expenditure KW - Psychiatric disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742723246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review&rft.atitle=Mental+Health+and+Family+Out-of-Pocket+Expenditure+Burdens&rft.au=Zuvekas%2C+Samuel+H%3BSelden%2C+Thomas+M&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2010-04-01&rft.volume=67&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558709345499 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-27 N1 - CODEN - MCRRFH N1 - SubjectsTermNotLitGenreText - Mental health services; Health costs; Personal expenditure; Psychiatric disorders; Expenditure DO - http://dx.doi.org/10.1177/1077558709345499 ER - TY - JOUR T1 - Organizational Context and Readiness for Change: A Study of Community-Based Parenting Programs in One Midwestern City AN - 741613404; 201007966 AB - Efficacious parent training programs are available, yet the gap between research and practice persists. Organizational factors influence the adoption and implementation of new treatments; however, little is known about social service agencies' organizational context and readiness for change. Twenty-one program directors (PDs) and 25 practitioners employed by 19 agencies providing parent training in a moderate-sized Midwestern city were surveyed to begin to fill this gap. PDs and practitioners had similar perceptions of agency culture and climate, and little interagency variation was evident. The atmosphere for adopting and implementing efficacious parent programs appeared favorable, although agencies may not feel sufficient pressure to change. Potential barriers to change and areas for future research are discussed. Adapted from the source document. JF - Administration in Social Work AU - Schurer, Jennifer AU - Kohl, Patricia L AU - Bellamy, Jennifer L AD - Center for Mental Health Services Research, Brown School of Social Work, Washington University, St. Louis, Missouri, USA Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 178 EP - 195 PB - Taylor & Francis, Philadelphia PA VL - 34 IS - 2 SN - 0364-3107, 0364-3107 KW - Parent Training KW - Cities KW - Agencies KW - Community Services KW - Adoption KW - Parents KW - article KW - 6152: community development/organizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741613404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+in+Social+Work&rft.atitle=Organizational+Context+and+Readiness+for+Change%3A+A+Study+of+Community-Based+Parenting+Programs+in+One+Midwestern+City&rft.au=Schurer%2C+Jennifer%3BKohl%2C+Patricia+L%3BBellamy%2C+Jennifer+L&rft.aulast=Schurer&rft.aufirst=Jennifer&rft.date=2010-04-01&rft.volume=34&rft.issue=2&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Administration+in+Social+Work&rft.issn=03643107&rft_id=info:doi/10.1080%2F03643101003609487 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-06-07 N1 - Number of references - 36 N1 - Last updated - 2016-09-28 N1 - CODEN - ASWODB N1 - SubjectsTermNotLitGenreText - Cities; Parent Training; Adoption; Agencies; Parents; Community Services DO - http://dx.doi.org/10.1080/03643101003609487 ER - TY - JOUR T1 - Carcinogenesis, bioassays, and the regulatory modus operandi. AN - 733934113; 20124497 JF - Toxicologic pathology AU - Lorentzen, Ronald J AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland 20740, USA. longgg@sbcglobal.net Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 506 EP - 507 VL - 38 IS - 3 KW - Index Medicus KW - Animals KW - Carcinogenicity Tests -- standards KW - Humans KW - Carcinogenicity Tests -- methods KW - Disease Models, Animal KW - Biological Assay -- methods KW - Biological Assay -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733934113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Carcinogenesis%2C+bioassays%2C+and+the+regulatory+modus+operandi.&rft.au=Lorentzen%2C+Ronald+J&rft.aulast=Lorentzen&rft.aufirst=Ronald&rft.date=2010-04-01&rft.volume=38&rft.issue=3&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623309358908 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Toxicol Pathol. 2010 Apr;38(3):487-501 [20215581] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623309358908 ER - TY - JOUR T1 - Variants in blood pressure genes and the risk of renal cell carcinoma. AN - 733839760; 20047954 AB - Hypertension is a known risk factor for renal cell carcinoma (RCC), although the underlying biological mechanisms of its action are unknown. To clarify the role of hypertension in RCC, we examined the risk of RCC in relation to 142 single-nucleotide polymorphisms (SNPs) in eight genes having a role in blood pressure control. We analyzed 777 incident and histologically confirmed RCC cases and 1035 controls who completed an in-person interview as part of a multi-center, hospital-based case-control study in Central Europe. Genotyping was conducted with an Illumina GoldenGate Oligo Pool All assay using germ line DNA. Of the eight genes examined, AGT (angiotensinogen) was most strongly associated with RCC (minimum P-value permutation test = 0.02). Of the 17 AGT tagging SNPs considered, associations were strongest for rs1326889 [odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.15-1.58] and rs2493137 (OR = 1.31, 95% CI = 1.12-1.54), which are located in the promoter. Stratified analysis revealed that the effects of the AGT SNPs were statistically significant in participants with hypertension or high body mass index (BMI) (> or =25 kg/m(2)), but not in subjects without hypertension and with a normal BMI (<25 kg/m(2)). Also, haplotypes with risk-conferring alleles of markers located in the promoter and intron 1 regions of AGT were significantly associated with RCC compared with the common haplotype in subjects with hypertension or high BMI (global P = 0.003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight. JF - Carcinogenesis AU - Andreotti, Gabriella AU - Boffetta, Paolo AU - Rosenberg, Philip S AU - Berndt, Sonja I AU - Karami, Sara AU - Menashe, Idan AU - Yeager, Meredith AU - Chanock, Stephen J AU - Zaridze, David AU - Matteev, Vsevolod AU - Janout, Vladimir AU - Kollarova, Hellena AU - Bencko, Vladimir AU - Navratilova, Marie AU - Szeszenia-Dabrowska, Neonilia AU - Mates, Dana AU - Rothman, Nathaniel AU - Brennan, Paul AU - Chow, Wong-Ho AU - Moore, Lee E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852-4906, USA. andreotg@mail.nih.gov Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 614 EP - 620 VL - 31 IS - 4 KW - Angiotensinogen KW - 11002-13-4 KW - Index Medicus KW - Haplotypes KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Body Mass Index KW - Linkage Disequilibrium KW - Male KW - Female KW - Hypertension -- complications KW - Angiotensinogen -- genetics KW - Polymorphism, Single Nucleotide KW - Carcinoma, Renal Cell -- etiology KW - Kidney Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733839760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Variants+in+blood+pressure+genes+and+the+risk+of+renal+cell+carcinoma.&rft.au=Andreotti%2C+Gabriella%3BBoffetta%2C+Paolo%3BRosenberg%2C+Philip+S%3BBerndt%2C+Sonja+I%3BKarami%2C+Sara%3BMenashe%2C+Idan%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BZaridze%2C+David%3BMatteev%2C+Vsevolod%3BJanout%2C+Vladimir%3BKollarova%2C+Hellena%3BBencko%2C+Vladimir%3BNavratilova%2C+Marie%3BSzeszenia-Dabrowska%2C+Neonilia%3BMates%2C+Dana%3BRothman%2C+Nathaniel%3BBrennan%2C+Paul%3BChow%2C+Wong-Ho%3BMoore%2C+Lee+E&rft.aulast=Andreotti&rft.aufirst=Gabriella&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=614&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp321 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Semin Cancer Biol. 2000 Aug;10(4):313-8 [10966853] J Hum Hypertens. 2010 Mar;24(3):213-9 [19536167] Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):1001-4 [11535554] Am J Hum Genet. 2002 Feb;70(2):425-34 [11791212] Cancer Causes Control. 2002 Apr;13(3):287-93 [12020111] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):513-20 [12050091] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Int J Cancer. 1995 Oct 9;63(2):216-21 [7591207] Mol Biol Evol. 1995 Sep;12(5):921-7 [7476138] Int J Cancer. 1996 Jun 11;66(6):723-6 [8647639] J Biol Chem. 1996 Jul 5;271(27):15981-6 [8663141] Br J Cancer. 1998 May;77(9):1508-13 [9652770] J Cardiovasc Risk. 1997 Oct-Dec;4(5-6):401-22 [9865673] Diabetologia. 1999 Jan;42(1):107-12 [10027588] Hypertension. 1999 Jun;33(6):1324-31 [10373210] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Genet Epidemiol. 2006 Sep;30(6):495-507 [16755536] Breast Cancer Res Treat. 2007 Mar;101(3):299-304 [16823505] Carcinogenesis. 2007 Sep;28(9):2036-40 [17389608] Carcinogenesis. 2007 Sep;28(9):1960-4 [17617661] Int J Cancer. 2008 Apr 15;122(8):1710-5 [18098291] Br J Cancer. 2008 Dec 2;99(11):1912-5 [19034282] Int J Colorectal Dis. 2009 Mar;24(3):289-94 [18704460] Cancer Res. 2009 Oct 15;69(20):8001-8 [19808960] N Engl J Med. 2000 Nov 2;343(18):1305-11 [11058675] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp321 ER - TY - JOUR T1 - Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. AN - 733839756; 20044584 AB - Epidemiological and mechanistic evidence on the association of quercetin-rich food intake with lung cancer risk and carcinogenesis are inconclusive. We investigated the role of dietary quercetin and the interaction between quercetin and P450 and glutathione S-transferase (GST) polymorphisms on lung cancer risk in 1822 incident lung cancer cases and 1991 frequency-matched controls from the Environment And Genetics in Lung cancer Etiology study. In non-tumor lung tissue from 38 adenocarcinoma patients, we assessed the correlation between quercetin intake and messenger RNA expression of the same P450 and GST metabolic genes. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for sex-specific quintiles of intake were calculated using unconditional logistic regression adjusting for putative risk factors. Frequent intake of quercetin-rich foods was inversely associated with lung cancer risk (OR = 0.49; 95% CI: 0.37-0.67; P-trend 20 cigarettes per day (OR = 0.35; 95% CI: 0.19-0.66; P-trend = 0.003). Based on a two-sample t-test, we compared gene expression and high versus low consumption of quercetin-rich foods and observed an overall upregulation of GSTM1, GSTM2, GSTT2, and GSTP1 as well as a downregulation of specific P450 genes (P-values < 0.05, adjusted for age and smoking status). In conclusion, we observed an inverse association of quercetin-rich food with lung cancer risk and identified a possible mechanism of quercetin-related changes in the expression of genes involved in the metabolism of tobacco carcinogens in humans. Our findings suggest an interplay between quercetin intake, tobacco smoking, and lung cancer risk. Further research on this relationship is warranted. JF - Carcinogenesis AU - Lam, Tram Kim AU - Rotunno, Melissa AU - Lubin, Jay H AU - Wacholder, Sholom AU - Consonni, Dario AU - Pesatori, Angela C AU - Bertazzi, Pier Alberto AU - Chanock, Stephen J AU - Burdette, Laurie AU - Goldstein, Alisa M AU - Tucker, Margaret A AU - Caporaso, Neil E AU - Subar, Amy F AU - Landi, Maria Teresa AD - Cancer Prevention Fellowship Program, Office of Preventive Oncology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 634 EP - 642 VL - 31 IS - 4 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Quercetin KW - 9IKM0I5T1E KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Vegetables KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Fruit KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Lung Neoplasms -- etiology KW - Quercetin -- administration & dosage KW - Cytochrome P-450 Enzyme System -- genetics KW - Glutathione Transferase -- genetics KW - Lung -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733839756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Dietary+quercetin%2C+quercetin-gene+interaction%2C+metabolic+gene+expression+in+lung+tissue+and+lung+cancer+risk.&rft.au=Lam%2C+Tram+Kim%3BRotunno%2C+Melissa%3BLubin%2C+Jay+H%3BWacholder%2C+Sholom%3BConsonni%2C+Dario%3BPesatori%2C+Angela+C%3BBertazzi%2C+Pier+Alberto%3BChanock%2C+Stephen+J%3BBurdette%2C+Laurie%3BGoldstein%2C+Alisa+M%3BTucker%2C+Margaret+A%3BCaporaso%2C+Neil+E%3BSubar%2C+Amy+F%3BLandi%2C+Maria+Teresa&rft.aulast=Lam&rft.aufirst=Tram&rft.date=2010-04-01&rft.volume=31&rft.issue=4&rft.spage=634&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp334 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-03-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: PLoS Med. 2006 Apr;3(4):e91 [16509765] Lung Cancer. 2009 Aug;65(2):129-37 [19185948] Curr Drug Metab. 2004 Jun;5(3):211-24 [15180491] Cancer Epidemiol Biomarkers Prev. 2004 Aug;13(8):1342-8 [15298956] Cancer Res. 1988 Oct 15;48(20):5754-8 [3139283] Carcinogenesis. 1991 Jul;12(7):1193-6 [2070483] Chem Res Toxicol. 1991 Jul-Aug;4(4):391-407 [1912325] Xenobiotica. 1995 Jun;25(6):575-84 [7483658] Eur J Clin Nutr. 1996 Feb;50(2):63-71 [8641249] BMJ. 1998 Apr 18;316(7139):1236-8 [9553006] Nutr Cancer. 1998;32(3):154-8 [10050265] Nutr Cancer. 1999;34(1):100-10 [10453448] Mutat Res. 2004 Nov;567(2-3):427-45 [15572289] Int J Epidemiol. 2004 Dec;33(6):1382-6 [15333618] Eur J Cancer. 2005 Jan;41(1):151-8 [15618000] J Nutr. 2005 Jul;135(7):1718-25 [15987855] Eur J Epidemiol. 2005;20(7):575-9 [16119429] Mutat Res. 2005 Dec 30;592(1-2):58-67 [16019037] Toxicol In Vitro. 2006 Mar;20(2):187-210 [16289744] Drug Metab Dispos. 2006 Feb;34(2):296-304 [16280456] Bioinformatics. 2006 Apr 15;22(8):943-9 [16473874] Br J Nutr. 2006 Oct;96(4):609-19 [17010218] Altern Ther Health Med. 2007 Mar-Apr;13(2):S108-11 [17405687] Forum Nutr. 2007;60:146-57 [17684411] Mol Cancer Ther. 2007 Sep;6(9):2591-9 [17876056] Biol Pharm Bull. 2007 Dec;30(12):2268-73 [18057710] PLoS One. 2008;3(2):e1651 [18297132] Cancer. 2008 May 15;112(10):2241-8 [18327817] BMC Public Health. 2008;8:203 [18538025] Cancer Lett. 2008 Oct 8;269(2):315-25 [18467024] Am J Epidemiol. 2008 Nov 1;168(9):1024-34 [18791192] J Cell Biochem. 2009 Jan 1;106(1):73-82 [19009557] J Natl Cancer Inst. 2000 Jan 19;92(2):154-60 [10639518] Nutr Cancer. 1999;35(2):175-9 [10693172] Altern Med Rev. 2000 Jun;5(3):196-208 [10869101] Drug Metab Rev. 2000 Aug-Nov;32(3-4):395-411 [11139137] Toxicol Lett. 2001 Feb 3;119(1):49-57 [11275421] Am J Epidemiol. 2001 Feb 15;153(4):394-403 [11207158] Cancer Res. 2001 Sep 15;61(18):6708-12 [11559540] Cancer Causes Control. 2001 Nov;12(9):789-96 [11714106] Am J Clin Nutr. 2002 Sep;76(3):560-8 [12198000] Toxicology. 2002 Nov 15;180(2):121-37 [12324189] Chem Biol Interact. 2003 May 6;145(2):139-48 [12686490] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):184-95 [19124497] PLoS One. 2009;4(5):e5652 [19479063] Am J Clin Nutr. 2003 Sep;78(3 Suppl):559S-569S [12936950] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp334 ER - TY - JOUR T1 - Biomarkers for drug-induced liver injury. AN - 733835943; 20350268 AB - Of the estimated 10,000 documented human drugs, more than 1000 have been associated with drug-induced liver injury (DILI), although causality has not always been established clearly. Numerous biomarkers for DILI have been explored, but less than ten are adopted or qualified as valid by the US FDA. The biomarkers for DILI are individual or a panel of proteins, nucleic acids or metabolites from various sources, such as the liver, blood and urine. While most DILI biomarkers are drug independent, some possibly 'drug-specific' DILIs have been explored, but specificity and sensitivity of both types need to be improved for the diagnosis of DILI during drug development and in clinical practice. Novel approaches for DILI biomarkers have been actively investigated recently, but produced mainly animal-based biomarkers, which are possibly useful for drug development, but are not suitable or have not been validated for clinical applications. This review summarizes the current practice and future perspectives for DILI biomarkers. JF - Expert review of gastroenterology & hepatology AU - Shi, Qiang AU - Hong, Huixiao AU - Senior, John AU - Tong, Weida AD - Center for Toxicoinformatics, Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 225 EP - 234 VL - 4 IS - 2 KW - Biomarkers KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Humans KW - Eosinophils KW - Proteomics KW - Biomarkers -- metabolism KW - Genomics KW - Liver -- enzymology KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Chemical and Drug Induced Liver Injury -- genetics KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733835943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+gastroenterology+%26+hepatology&rft.atitle=Biomarkers+for+drug-induced+liver+injury.&rft.au=Shi%2C+Qiang%3BHong%2C+Huixiao%3BSenior%2C+John%3BTong%2C+Weida&rft.aulast=Shi&rft.aufirst=Qiang&rft.date=2010-04-01&rft.volume=4&rft.issue=2&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+gastroenterology+%26+hepatology&rft.issn=1747-4132&rft_id=info:doi/10.1586%2Fegh.10.8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-03 N1 - Date created - 2010-03-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Expert Rev Gastroenterol Hepatol. 2010 Dec;4(6):798 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1586/egh.10.8 ER - TY - JOUR T1 - Knowledge of dietary fats among US consumers. AN - 733834964; 20338288 AB - Dietary advice emphasizes that some dietary fats increase the risk of heart disease, whereas other dietary fats decrease risk if they are substituted for more risk-increasing fats. Thus, it is important that consumers understand the differences between dietary fats. Existing evidence in the United States suggests troublesome consumer misunderstanding. As part of its continuing effort to promote public health, the US Food and Drug Administration measured consumer awareness and understanding of dietary fats in its Health and Diet Survey- 2004 Supplement. After cognitive interviews and pretests of the questionnaire, telephone interviews of randomly selected noninstitutionalized adults aged 18 years and older in the United States were conducted between October 12, 2004, and January 21, 2005. Using cross-sectional data collected from 1,798 respondents who completed the survey, this study estimated the prevalence of awareness and understanding of six dietary fats among US adults and identified the characteristics of adults with different levels of awareness and understanding. Descriptive analyses were used, along with logistic regression models, developed to accommodate the survey design and responses. There was a wide disparity among US consumers in their awareness and understanding. Saturated fat was most recognized and understood, whereas awareness of other fats was much lower. Most importantly, having heard of a fat did not necessarily mean understanding its relationship to heart disease. Only half of those who had heard of trans fat and n-3 fatty acids understood that the fats raise and lower the risk of heart disease, respectively. Only a minority of those who had heard of partially hydrogenated oil and polyunsaturated fat knew the fats raise and lower the risk of heart disease, respectively. Many admitted being uncertain about how a fat relates to the risk of heart disease. College or more-educated adults had better awareness and understanding. Nonwhite adults were less knowledgeable. Findings on the awareness and understanding and how they are related to individual characteristics can inform deliberations about educational messages, nutrition programs, and food labeling about dietary fats to promote public health. Copyright (c) 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved. JF - Journal of the American Dietetic Association AU - Lin, Chung-Tung J AU - Yen, Steven T AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA. Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 613 EP - 618 VL - 110 IS - 4 KW - Dietary Fats KW - 0 KW - Dietary Fats, Unsaturated KW - Trans Fatty Acids KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Odds Ratio KW - Cardiovascular Diseases -- etiology KW - Humans KW - African Americans -- statistics & numerical data KW - European Continental Ancestry Group -- psychology KW - Dietary Fats, Unsaturated -- adverse effects KW - European Continental Ancestry Group -- statistics & numerical data KW - Nutritional Physiological Phenomena -- physiology KW - Health Education KW - Cardiovascular Diseases -- prevention & control KW - Food Labeling KW - Trans Fatty Acids -- administration & dosage KW - Hispanic Americans -- statistics & numerical data KW - Dietary Fats, Unsaturated -- administration & dosage KW - Logistic Models KW - African Americans -- psychology KW - Middle Aged KW - Hispanic Americans -- psychology KW - Trans Fatty Acids -- adverse effects KW - Male KW - Female KW - Dietary Fats -- adverse effects KW - Health Knowledge, Attitudes, Practice KW - Dietary Fats -- administration & dosage KW - Awareness KW - Nutritional Sciences -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733834964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Dietetic+Association&rft.atitle=Knowledge+of+dietary+fats+among+US+consumers.&rft.au=Lin%2C+Chung-Tung+J%3BYen%2C+Steven+T&rft.aulast=Lin&rft.aufirst=Chung-Tung&rft.date=2010-04-01&rft.volume=110&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Dietetic+Association&rft.issn=1878-3570&rft_id=info:doi/10.1016%2Fj.jada.2009.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-01 N1 - Date created - 2010-03-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jada.2009.12.020 ER - TY - JOUR T1 - BREAKING GROUND AN - 235025101 AB - [TAYLOR]'S DESIGN TEAM FOLLOWED THE "GREEN GUIDE FOR HEALTH CARE" AND LEED CONCEPTS IN THE DESIGN OF MILLER CHILDREN'S HOSPITAL. PHOTOS BY ASSASSI PRODUCTIONS. JF - Environmental Design + Construction AU - Barda, Damon, AIA, LEED AP Y1 - 2010/04// PY - 2010 DA - Apr 2010 SP - 22 EP - 25 CY - Troy PB - BNP Media VL - 13 IS - 4 SN - 10958932 KW - Building And Construction KW - Hospitals KW - Green buildings KW - Architecture KW - Brownfields KW - Best practice KW - Project management KW - United States--US KW - 8370:Construction & engineering industry KW - 9190:United States KW - 1540:Pollution control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/235025101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabitrade&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Design+%2B+Construction&rft.atitle=BREAKING+GROUND&rft.au=Barda%2C+Damon%2C+AIA%2C+LEED+AP&rft.aulast=Barda&rft.aufirst=Damon&rft.date=2010-04-01&rft.volume=13&rft.issue=4&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Environmental+Design+%2B+Construction&rft.issn=10958932&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Miller Childrens Hospital-Long Beach CA N1 - Copyright - Copyright BNP Media Apr 2010 N1 - Document feature - Photographs N1 - Last updated - 2014-05-20 N1 - SubjectsTermNotLitGenreText - United States--US ER - TY - GEN T1 - Compendium of Quality Rating Systems and Evaluations: The Child Care Quality Rating System (QRS) Assessment AN - 1826540658; ED566258 AB - Quality Rating Systems (QRS) are currently operating, under development, or being piloted in over 25 states or local areas. As the QRS model becomes integrated into the landscape of child care and education service delivery, policy, and the decisions parents make about child care across the United States, there is an increasing need for descriptive and comparative information about QRS implementation and evaluation. Acknowledging this need, the Office of Planning, Research and Evaluation (OPRE) in the Administration for Children and Families (ACF), U.S. Department of Health and Human Services (DHHS) is supporting a project called the Child Care Quality Rating System Assessment (QRS Assessment). The goal of the QRS Assessment is to provide information, analysis and resources about QRS for states and other key stakeholders. The Compendium of Quality Rating Systems and Evaluations is the first product of the QRS Assessment and is intended to serve as a rich resource for the other tasks in the QRS Assessment which include a multi case in depth study, secondary analysis of existing QRS data, an analytic paper, and a toolkit for designing research and evaluation of QRS. The Compendium is intended to be a source of detailed information about QRS that can be compared, analyzed and used to generate hypotheses or research questions that can be addressed in the other QRS Assessment tasks. The Compendium contains two different types of information about QRS. The first section presents descriptive information obtained by examining 26 QRS nationwide. Cross-QRS matrices are included to simplify the information and to facilitate a review across states. The second section contains individual profiles of the 26 QRS in which data were collected for the QRS Assessment. Data were collected from July to October, 2009 and were finalized in early 2010. The purpose of the Compendium is to provide definitions, description, and an analytic framework for assessing the critical elements of QRS and QRS evaluations. Appended are: (1) Expert Panel Members; (2) Template used for Quality Rating System Profiles (with explanation of data elements); and (3) Quality Rating System Profiles (appear individually under separate cover). AU - Tout, Kathryn AU - Starr, Rebecca AU - Soli, Margaret AU - Moodie, Shannon AU - Kirby, Gretchen AU - Boller, Kimberly Y1 - 2010/04// PY - 2010 DA - April 2010 SP - 251 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - California KW - Colorado KW - Delaware KW - District of Columbia KW - Florida KW - Illinois KW - Indiana KW - Iowa KW - Kentucky KW - Louisiana KW - Maine KW - Maryland KW - Minnesota KW - Mississippi KW - Missouri KW - New Hampshire KW - New Mexico KW - North Carolina KW - Ohio KW - Oklahoma KW - Oregon KW - Pennsylvania KW - Tennessee KW - Vermont KW - Virginia KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Program Descriptions KW - Outreach Programs KW - Improvement Programs KW - Observation KW - Child Care KW - Incentives KW - Measurement Techniques KW - Rating Scales KW - Profiles KW - Marketing KW - Program Evaluation KW - Standards KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826540658?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Influence of Candida pulcherrima Patagonian strain on alcoholic fermentation behaviour and wine aroma AN - 853488283; 14334265 AB - The use of selected Saccharomyces and non-Saccharomyces strains as mixed starters in winemaking would have advantages over the traditional spontaneous fermentation, producing wines with predictable and desirable characteristics. The aim of this study was to evaluate the impact of metabolic interactions between Patagonian indigenous Saccharomyces cerevisiae MMf9 and beta -glucosidase producer Candida pulcherrima V sub(6) strains on alcoholic fermentation behaviour and wine aroma Three inoculation strategies, simultaneous, sequential and final, were assayed at laboratory-scale fermentations using Muscat d'Alexandrie grape juice as substrate. The fermentation and yeast growth kinetics as well as the physicochemical and the sensory quality of wine were evaluated. Results evidenced that the sequential inoculation is the most adequate strategy of strains combination. The kinetic behaviour of sequential fermentation was similar to a successful spontaneous fermentation and its wine showed differential aromatic quality as evidenced through PC analysis using physicochemical and aromatic composition data. This wine presented the highest total concentration of higher alcohol, esters and terpenols and the strongest fruity and floral aroma. JF - International Journal of Food Microbiology AU - Rodriguez, Maria Eugenia AU - Lopes, Christian A AU - Barbagelata, Raul J AU - Barda, Nora B AU - Caballero, Adriana C AD - Departamento de Quimica, Laboratorio de Microbiologia y Biotecnologia, Facultad de Ingenieria, Universidad Nacional del Comahue, Buenos Aires 1400, (8300) Neuquen, Argentina, ecastro@neunet.com.ar Y1 - 2010/03/31/ PY - 2010 DA - 2010 Mar 31 SP - 19 EP - 25 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 138 IS - 1-2 SN - 0168-1605, 0168-1605 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Chemoreception Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Candida pulcherrima KW - Data processing KW - Fermentation KW - Juices KW - Esters KW - Saccharomyces cerevisiae KW - Sensory properties KW - Kinetics KW - Inoculation KW - alcohols KW - beta -Glucosidase KW - Vitaceae KW - Aromatics KW - Wine KW - Aroma KW - R 18065:Food science KW - K 03300:Methods KW - W 30955:Biosensors KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853488283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Influence+of+Candida+pulcherrima+Patagonian+strain+on+alcoholic+fermentation+behaviour+and+wine+aroma&rft.au=Rodriguez%2C+Maria+Eugenia%3BLopes%2C+Christian+A%3BBarbagelata%2C+Raul+J%3BBarda%2C+Nora+B%3BCaballero%2C+Adriana+C&rft.aulast=Rodriguez&rft.aufirst=Maria&rft.date=2010-03-31&rft.volume=138&rft.issue=1-2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2009.12.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Sensory properties; Data processing; Fermentation; Kinetics; Juices; alcohols; Inoculation; beta -Glucosidase; Esters; Aromatics; Aroma; Wine; Candida pulcherrima; Vitaceae; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2009.12.025 ER - TY - JOUR T1 - Gene expression profiling in the developing rat brain exposed to ketamine. AN - 733525009; 20080153 AB - Ketamine, a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, is associated with accelerated neuronal apoptosis in the developing rodent brain. In this study, postnatal day (PND) 7 rats were treated with 20 mg/kg ketamine or saline in six successive doses (s.c.) at 2-h intervals. Brain frontal cortical areas were collected 6 h after the last dose and RNA isolated and hybridized to Illumina Rat Ref-12 Expression BeadChips containing 22,226 probes. Many of the differentially expressed genes were associated with cell death or differentiation and receptor activity. Ingenuity Pathway Analysis software identified perturbations in NMDA-type glutamate, GABA and dopamine receptor signaling. Quantitative polymerase chain reaction (Q-PCR) confirmed that NMDA receptor subunits were significantly up-regulated. Up-regulation of NMDA receptor mRNA signaling was further confirmed by in situ hybridization. These observations support our working hypothesis that prolonged ketamine exposure produces up-regulation of NMDA receptors and subsequent over-stimulation of the glutamatergic system by endogenous glutamate, triggering enhanced apoptosis in developing neurons. Published by Elsevier Ltd. JF - Neuroscience AU - Shi, Q AU - Guo, L AU - Patterson, T A AU - Dial, S AU - Li, Q AU - Sadovova, N AU - Zhang, X AU - Hanig, J P AU - Paule, M G AU - Slikker, W AU - Wang, C AD - Division of Systems Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2010/03/31/ PY - 2010 DA - 2010 Mar 31 SP - 852 EP - 863 VL - 166 IS - 3 KW - Anesthetics, General KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - Ketamine KW - 690G0D6V8H KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Terminology as Topic KW - Rats KW - Animals, Newborn KW - Polymerase Chain Reaction KW - Receptors, N-Methyl-D-Aspartate -- biosynthesis KW - In Situ Hybridization KW - Down-Regulation KW - Up-Regulation KW - Female KW - Male KW - Signal Transduction KW - Gene Expression Profiling KW - Ketamine -- toxicity KW - Brain -- drug effects KW - Brain -- metabolism KW - Anesthetics, General -- toxicity KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733525009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Gene+expression+profiling+in+the+developing+rat+brain+exposed+to+ketamine.&rft.au=Shi%2C+Q%3BGuo%2C+L%3BPatterson%2C+T+A%3BDial%2C+S%3BLi%2C+Q%3BSadovova%2C+N%3BZhang%2C+X%3BHanig%2C+J+P%3BPaule%2C+M+G%3BSlikker%2C+W%3BWang%2C+C&rft.aulast=Shi&rft.aufirst=Q&rft.date=2010-03-31&rft.volume=166&rft.issue=3&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2010.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-17 N1 - Date created - 2010-03-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neuroscience.2010.01.007 ER - TY - JOUR T1 - Evaluation of droplet velocity and size from nasal spray devices using phase Doppler anemometry (PDA) AN - 745705242; 12965995 AB - To determine aerosol deposition during the inhalation drug delivery, it is important to understand the combination of velocity and droplet size together. In this study, phase Doppler anemometry (PDA) was used to simultaneously characterize the aerosol velocity and droplet size distribution (DSD) of three nasal spray pumps filled with water. Thirteen sampling positions were located in the horizontal cross-sectional area of the nasal spray plumes at a distance of 3 cm from the pump orifice. The results showed droplet velocities near the center of the spray plume were higher and more consistent than those near the edge. The pumps examined showed significant differences in their aerosol velocity at the center of the spray plume, which suggest that this metric might be used as a discriminating parameter for in vitro testing of nasal sprays. Droplet size measurements performed using PDA were compared with results from laser light scattering measurements. The ability of PDA to provide simultaneous measurements of aerosol velocity and size makes it a powerful tool for the detailed investigation of nasal spray plume characteristics. JF - International Journal of Pharmaceutics AU - Liu, Xiaofei AU - Doub, William H AU - Guo, Changning AD - U.S. Food & Drug Administration, Division of Pharmaceutical Analysis, 1114 Market Street, Room 1002, St. Louis, MO 63101, United States, changning.guo@fda.hhs.gov Y1 - 2010/03/30/ PY - 2010 DA - 2010 Mar 30 SP - 82 EP - 87 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 388 IS - 1-2 SN - 0378-5173, 0378-5173 KW - Biotechnology and Bioengineering Abstracts KW - Nasal spray KW - In vitro test KW - Aerosol KW - Velocity KW - Size KW - Phase Doppler anemometry KW - Inhalation KW - Drug delivery KW - Aerosols KW - Light scattering KW - Lasers KW - Sampling KW - Plumes KW - Size distribution KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745705242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Pharmaceutics&rft.atitle=Evaluation+of+droplet+velocity+and+size+from+nasal+spray+devices+using+phase+Doppler+anemometry+%28PDA%29&rft.au=Liu%2C+Xiaofei%3BDoub%2C+William+H%3BGuo%2C+Changning&rft.aulast=Liu&rft.aufirst=Xiaofei&rft.date=2010-03-30&rft.volume=388&rft.issue=1-2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Pharmaceutics&rft.issn=03785173&rft_id=info:doi/10.1016%2Fj.ijpharm.2009.12.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inhalation; Drug delivery; Aerosols; Light scattering; Lasers; Sampling; Plumes; Size distribution DO - http://dx.doi.org/10.1016/j.ijpharm.2009.12.041 ER - TY - JOUR T1 - (Bi)sulfite Oxidation by Copper,Zinc-Superoxide Dismutase: Sulfite-Derived, Radical-Initiated Protein Radical Formation AN - 877593434; 13640153 AB - Sulfur dioxide, formed during the combustion of fossil fuels, is a major air pollutant near large cities. Its two ionized forms in aqueous solution, sulfite and (bi)sulfite, are widely used as preservatives and antioxidants to prevent food and beverage spoilage. (Bi)sulfite can be oxidized by peroxidases to form the very reactive sulfur trioxide anion radical (; SO3-). This free radical further reacts with oxygen to form the peroxymonosulfate anion radical (-O3SOO; ) and sulfate anion radical (SO4; -). To explore the critical role of these radical intermediates in further oxidizing biomolecules, we examined the ability of copper,zinc-superoxide dismutase (Cu,Zn-SOD) to initiate this radical chain reaction, using human serum albumin (HSA) as a model target. We used electron paramagnetic resonance, optical spectroscopy, oxygen uptake, and immuno-spin trapping to study the protein oxidations driven by sulfite-derived radicals. We found that when Cu,Zn-SOD reacted with (bi)sulfite, ; SO3- was produced, with the concomitant reduction of SOD-Cu(II) to SOD-Cu(I). Further, we demonstrated that sulfite oxidation mediated by Cu,Zn-SOD induced the formation of radical-derived 5,5-dimethyl-1-pyrroline N-oxide (DMPO) spin-trapped HSA radicals. The present study suggests that protein oxidative damage resulting from (bi)sulfite oxidation promoted by Cu,Zn-SOD could be involved in oxidative damage and tissue injury in (bi)sulfite-exacerbated allergic reactions. JF - Environmental Health Perspectives AU - Ranguelova, Kalina AU - Bonini, Marcelo G AU - Mason, Ronald P AD - Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2010/03/26/ PY - 2010 DA - 2010 Mar 26 SP - 970 EP - 975 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 USA VL - 118 IS - 7 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Pollution Abstracts KW - ESR spin trapping KW - immuno-spin trapping KW - sulfite radicals KW - sulfite toxicity KW - Air pollution KW - Oxygen KW - Anions KW - Sulfur dioxide KW - Oxidation KW - Proteins KW - Sulfites KW - Preservatives KW - Combustion KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877593434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=%28Bi%29sulfite+Oxidation+by+Copper%2CZinc-Superoxide+Dismutase%3A+Sulfite-Derived%2C+Radical-Initiated+Protein+Radical+Formation&rft.au=Ranguelova%2C+Kalina%3BBonini%2C+Marcelo+G%3BMason%2C+Ronald+P&rft.aulast=Ranguelova&rft.aufirst=Kalina&rft.date=2010-03-26&rft.volume=118&rft.issue=7&rft.spage=970&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.0901533 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Air pollution; Oxygen; Sulfur dioxide; Anions; Oxidation; Sulfites; Proteins; Preservatives; Combustion DO - http://dx.doi.org/10.1289/ehp.0901533 ER - TY - CPAPER T1 - Driving Change through Research: Making Tomorrow's Vision Today's Reality With Patient-Centered Care T2 - 16th Annual HMO Research Network Conference (HMORN 2010) AN - 742819872; 5704493 JF - 16th Annual HMO Research Network Conference (HMORN 2010) AU - Clancy, Carolyn Y1 - 2010/03/21/ PY - 2010 DA - 2010 Mar 21 KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742819872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+HMO+Research+Network+Conference+%28HMORN+2010%29&rft.atitle=Driving+Change+through+Research%3A+Making+Tomorrow%27s+Vision+Today%27s+Reality+With+Patient-Centered+Care&rft.au=Clancy%2C+Carolyn&rft.aulast=Clancy&rft.aufirst=Carolyn&rft.date=2010-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+HMO+Research+Network+Conference+%28HMORN+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.hmoresearchnetwork.org/confpgs/conf.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - How FDA Approaches Neurocognitive Disorders in the Psychopharmacology Division T2 - 21st Annual Meeting American Neuropsychiatric Association AN - 742812591; 5684422 JF - 21st Annual Meeting American Neuropsychiatric Association AU - Laughren, Thomas Y1 - 2010/03/17/ PY - 2010 DA - 2010 Mar 17 KW - FDA KW - Cognition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742812591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Annual+Meeting+American+Neuropsychiatric+Association&rft.atitle=How+FDA+Approaches+Neurocognitive+Disorders+in+the+Psychopharmacology+Division&rft.au=Laughren%2C+Thomas&rft.aulast=Laughren&rft.aufirst=Thomas&rft.date=2010-03-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Annual+Meeting+American+Neuropsychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.anpaonline.org/13707.cfm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort AN - 746002674; 12746385 AB - BACKGROUND: In most populations, incidence rates of upper gastrointestinal (UGI) tract cancers (head and neck, esophagus, and stomach) are higher among men than among women. Established risk factors do not appear to explain these differences, suggesting a possible role for sex hormones. METHODS: 201,506 women of the NIH-AARP Diet and Health cohort completed a questionnaire in 1995-1996. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models. RESULTS: During follow-up through 2003, 162 incident adenocarcinomas (ACs; esophagus, N = 25, and stomach, N = 137) and 353 incident squamous cell carcinomas (SCCs; head and neck, n = 297, and esophagus, N = 56) occurred. Among examined exposures, older age at menopause was associated inversely with SCC (Ptrend across categories = .013) but not AC (Ptrend = .501). Use of menopausal hormone therapy (MHT) was significantly associated with lower risk of SCC (hazard ratio [HR] = 0.7,0.62-0.96) and nonsignificantly associated with lower risk of AC (HR = 0.8,0.59-1.12). A subset (N = 127,386) of the cohort completed a more detailed MHT questionnaire a year after baseline. In 74,372 women with intact uteri, ever use of estrogen-progestin MHT conferred 0.47 (0.30-0.75) times the risk for SCC and 0.52 (0.26-1.07) times the risk for ACC. In 51,515 women with a hysterectomy before baseline, we found no associations between use of estrogen MHT and AC or SCC. CONCLUSIONS: Higher estrogen and progesterone levels may be related inversely to UGI cancers and in this way help explain lower incidence rates in women compared with men. Cancer 2010. JF - Cancer AU - Freedman, Neal D AU - Lacey Jr, James V AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, freedmanne@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 1572 EP - 1581 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 116 IS - 6 SN - 0008-543X, 0008-543X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Diets KW - Age KW - menopause KW - Hormones KW - Cancer KW - estrogens KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746002674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=The+association+of+menstrual+and+reproductive+factors+with+upper+gastrointestinal+tract+cancers+in+the+NIH-AARP+cohort&rft.au=Freedman%2C+Neal+D%3BLacey+Jr%2C+James+V%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2010-03-15&rft.volume=116&rft.issue=6&rft.spage=1572&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.24880 L2 - http://www3.interscience.wiley.com/journal/123300153/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Diets; Age; menopause; Hormones; Cancer; estrogens DO - http://dx.doi.org/10.1002/cncr.24880 ER - TY - CPAPER T1 - Efficient Inactivation of Mycoplasmas During Production of Biologics: Egg-based Viral Vaccines as a Model T2 - 2010 PDA Annual Meeting (PDA 2010) AN - 742799501; 5675024 JF - 2010 PDA Annual Meeting (PDA 2010) AU - Volokhov, Dmitriy Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 KW - Vaccines KW - Inactivation KW - Models KW - Disease control KW - Mycoplasma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742799501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+PDA+Annual+Meeting+%28PDA+2010%29&rft.atitle=Efficient+Inactivation+of+Mycoplasmas+During+Production+of+Biologics%3A+Egg-based+Viral+Vaccines+as+a+Model&rft.au=Volokhov%2C+Dmitriy&rft.aulast=Volokhov&rft.aufirst=Dmitriy&rft.date=2010-03-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+PDA+Annual+Meeting+%28PDA+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://pdaannualmeeting.org/pdf/annual-brochure.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association. AN - 733713065; 20215514 AB - Although the relation between red and processed meat intake and colorectal cancer has been reported in several epidemiologic studies, very few investigated the potential mechanisms. This study examined multiple potential mechanisms in a large U.S. prospective cohort with a detailed questionnaire on meat type and meat cooking methods linked to databases for estimating intake of mutagens formed in meats cooked at high temperatures (heterocyclic amines, polycyclic aromatic hydrocarbons), heme iron, nitrate, and nitrite. During 7 years of follow-up, 2,719 colorectal cancer cases were ascertained from a cohort of 300,948 men and women. The hazard ratios (HR) and 95% confidence intervals (95% CI) comparing the fifth to the first quintile for both red (HR, 1.24; 95% CI, 1.09-1.42; P(trend) < 0.001) and processed meat (HR, 1.16; 95% CI, 1.01-1.32; P(trend) = 0.017) intakes indicated an elevated risk for colorectal cancer. The potential mechanisms for this relation include heme iron (HR, 1.13; 95% CI, 0.99-1.29; P(trend) = 0.022), nitrate from processed meats (HR, 1.16; 95% CI, 1.02-1.32; P(trend) = 0.001), and heterocyclic amine intake [HR, 1.19; 95% CI, 1.05-1.34; P(trend) < 0.001 for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and HR, 1.17; 95% CI, 1.05-1.29; P(trend) <0.001 for 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx)]. In general, the elevated risks were higher for rectal cancer than for colon cancer, with the exception of MeIQx and DiMeIQx, which were only associated with colon cancer. In conclusion, we found a positive association for red and processed meat intake and colorectal cancer; heme iron, nitrate/nitrite, and heterocyclic amines from meat may explain these associations. JF - Cancer research AU - Cross, Amanda J AU - Ferrucci, Leah M AU - Risch, Adam AU - Graubard, Barry I AU - Ward, Mary H AU - Park, Yikyung AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Biostatistics Branch, Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Rockville, Maryland, USA. crossa@mail.nih.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 2406 EP - 2414 VL - 70 IS - 6 KW - Imidazoles KW - 0 KW - Quinoxalines KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline KW - 92180-79-5 KW - Index Medicus KW - Prospective Studies KW - Quinoxalines -- analysis KW - Humans KW - Cooking KW - Cohort Studies KW - Surveys and Questionnaires KW - Middle Aged KW - Imidazoles -- analysis KW - United States -- epidemiology KW - Male KW - Female KW - Meat -- statistics & numerical data KW - Diet -- statistics & numerical data KW - Colorectal Neoplasms -- etiology KW - Meat -- analysis KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733713065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=A+large+prospective+study+of+meat+consumption+and+colorectal+cancer+risk%3A+an+investigation+of+potential+mechanisms+underlying+this+association.&rft.au=Cross%2C+Amanda+J%3BFerrucci%2C+Leah+M%3BRisch%2C+Adam%3BGraubard%2C+Barry+I%3BWard%2C+Mary+H%3BPark%2C+Yikyung%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2010-03-15&rft.volume=70&rft.issue=6&rft.spage=2406&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-09-3929 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-26 N1 - Date created - 2010-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Nov 15;59(22):5704-9 [10582688] Food Chem Toxicol. 2001 May;39(5):423-36 [11313108] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1259-66 [11751443] Pharmacogenetics. 2002 Mar;12(2):145-50 [11875368] Mutat Res. 2002 Aug 26;519(1-2):151-61 [12160900] Int J Cancer. 2002 Oct 10;101(5):403-8 [12216066] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Cancer Epidemiol Biomarkers Prev. 2002 Oct;11(10 Pt 1):1019-24 [12376502] Epidemiology. 2003 Mar;14(2):183-90 [12606884] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Epidemiology. 2003 Nov;14(6):640-9 [14569178] J Natl Cancer Inst. 2004 Mar 3;96(5):403-7 [14996862] J Nutr. 2004 Oct;134(10):2711-6 [15465771] Mutat Res. 1991 Mar-Apr;259(3-4):399-410 [2017219] Cancer Epidemiol Biomarkers Prev. 1994 Dec;3(8):675-82 [7881341] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1626-32 [16030093] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2030-4 [16103456] Cancer Res. 2005 Sep 1;65(17):8034-41 [16140978] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):717-25 [16614114] Epidemiology. 2006 Jul;17(4):375-82 [16699473] Med Hypotheses. 2007;68(3):562-4 [17045417] Carcinogenesis. 2007 Jun;28(6):1210-6 [17277235] Br J Cancer. 2007 Jul 2;97(1):118-22 [17551493] Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):320-9 [18268115] Am J Gastroenterol. 2009 May;104(5):1231-40 [19367270] Cancer Epidemiol Biomarkers Prev. 2009 Jul;18(7):2098-106 [19549810] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Carcinogenesis. 2000 Oct;21(10):1909-15 [11023550] Comment In: Acta Gastroenterol Latinoam. 2011 Mar;41(1):70-3 [21539071] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1158/0008-5472.CAN-09-3929 ER - TY - JOUR T1 - High-performance liquid chromatography electrospray ionization tandem mass spectrometry for the detection and quantitation of pyrrolizidine alkaloid-derived DNA adducts in vitro and in vivo. AN - 733472554; 20078085 AB - Pyrrolizidine alkaloid-containing plants are widespread in the world and are probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids require metabolism to exert their genotoxicity and tumorigenicity. We have determined that the metabolism of a series of tumorigenic pyrrolizidine alkaloids in vitro or in vivo generates a common set of (+/-)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts that are responsible for tumor induction. The identification and quantitation of the DHP-derived DNA adducts formed in vivo and in vitro were accomplished previously by (32)P-postlabeling/HPLC methodology. In this article, we report the development of a sensitive and specific liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ES-MS/MS) method to detect DHP-derived DNA adducts formed in vitro and in vivo. The method is used to quantify the levels of DHP-2'-deoxyguanosine (dG) and DHP-2'-deoxyadenosine (dA) adducts by multiple reaction monitoring (MRM) analysis in the presence of known quantities of isotopically labeled DHP-dG and DHP-dA internal standards. This HPLC-ES-MS/MS method is accurate and precise. When applied to liver samples from rats treated with the pyrrolizidine alkaloids riddelliine and monocrotaline, the method provided significant new information regarding the mechanism of DNA adduct formation. JF - Chemical research in toxicology AU - Fu, Peter P AU - Chou, Ming W AU - Churchwell, Mona AU - Wang, Yuping AU - Zhao, Yuewei AU - Xia, Qingsu AU - Gamboa da Costa, Gonçalo AU - Marques, M Matilde AU - Beland, Frederick A AU - Doerge, Daniel R AD - National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. peter.fu@fda.hhs.gov Y1 - 2010/03/15/ PY - 2010 DA - 2010 Mar 15 SP - 637 EP - 652 VL - 23 IS - 3 KW - DNA Adducts KW - 0 KW - Pyrrolizidine Alkaloids KW - DNA KW - 9007-49-2 KW - calf thymus DNA KW - 91080-16-9 KW - Index Medicus KW - Sensitivity and Specificity KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Cattle KW - DNA -- metabolism KW - Tandem Mass Spectrometry -- methods KW - DNA -- analysis KW - Liver -- metabolism KW - Calibration KW - Female KW - Pyrrolizidine Alkaloids -- adverse effects KW - DNA Adducts -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - DNA Adducts -- metabolism KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733472554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=High-performance+liquid+chromatography+electrospray+ionization+tandem+mass+spectrometry+for+the+detection+and+quantitation+of+pyrrolizidine+alkaloid-derived+DNA+adducts+in+vitro+and+in+vivo.&rft.au=Fu%2C+Peter+P%3BChou%2C+Ming+W%3BChurchwell%2C+Mona%3BWang%2C+Yuping%3BZhao%2C+Yuewei%3BXia%2C+Qingsu%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BMarques%2C+M+Matilde%3BBeland%2C+Frederick+A%3BDoerge%2C+Daniel+R&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2010-03-15&rft.volume=23&rft.issue=3&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx900402x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-29 N1 - Date created - 2010-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1021/tx900402x ER - TY - CPAPER T1 - Collaborative Immunological Bridging Study to Replace 89SF Reference Serum with a New Pneumococcal Reference Serum, 007 T2 - 7th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-7) AN - 742821281; 5701756 JF - 7th International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD-7) AU - Lee, L Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - Serum KW - Streptococcus pneumoniae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742821281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Symposium+on+Pneumococci+and+Pneumococcal+Diseases+%28ISPPD-7%29&rft.atitle=Collaborative+Immunological+Bridging+Study+to+Replace+89SF+Reference+Serum+with+a+New+Pneumococcal+Reference+Serum%2C+007&rft.au=Lee%2C+L&rft.aulast=Lee&rft.aufirst=L&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Symposium+on+Pneumococci+and+Pneumococcal+Diseases+%28ISPPD-7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sessionplan.com/isppd2010/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Regulatory Uncertainty: The Regulator's Perspective T2 - 2010 Gordon Research Conference on New Antibacterial Discovery & Development AN - 742797093; 5678918 JF - 2010 Gordon Research Conference on New Antibacterial Discovery & Development AU - Cox, Edward Y1 - 2010/03/14/ PY - 2010 DA - 2010 Mar 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742797093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Gordon+Research+Conference+on+New+Antibacterial+Discovery+%26+Development&rft.atitle=Regulatory+Uncertainty%3A+The+Regulator%27s+Perspective&rft.au=Cox%2C+Edward&rft.aulast=Cox&rft.aufirst=Edward&rft.date=2010-03-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Gordon+Research+Conference+on+New+Antibacterial+Discovery+%26+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.grc.org/programs.aspx?year=2010&program=antibact LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Occupational Exposure to Naturally Occurring Asbestos (Noa) T2 - 2010 Northeastern / Southeastern Joint Section Meeting of the Geological Society of America AN - 754203007; 5754062 JF - 2010 Northeastern / Southeastern Joint Section Meeting of the Geological Society of America AU - Harper, Martin Y1 - 2010/03/13/ PY - 2010 DA - 2010 Mar 13 KW - Occupational exposure KW - Asbestos KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754203007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Northeastern+%2F+Southeastern+Joint+Section+Meeting+of+the+Geological+Society+of+America&rft.atitle=Occupational+Exposure+to+Naturally+Occurring+Asbestos+%28Noa%29&rft.au=Harper%2C+Martin&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2010-03-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Northeastern+%2F+Southeastern+Joint+Section+Meeting+of+the+Geological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.geosociety.org/sectdiv/northe/2010mtg/ne-se2010_awp.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - JOUR T1 - Medical surveillance, exposure registries, and epidemiologic research for workers exposed to nanomaterials AN - 746149843; 12931532 AB - While there is a growing body of information about hazards of nanomaterials, little is known about the risks to workers exposed to them. However, workers are the first people in society that are being exposed to the growing inventory of "nano-enabled" products in commerce. The number of workers involved in the investigation, manufacture, production, and disposal of these types of products is growing. Although toxicologic research is still the highest priority, it is time to actively anticipate the health needs of workers. To date, precautionary risk management approaches have been widely advocated. Now there is a need to initiate an evolving process to identify the issues in medical surveillance, utilization of exposure registries, and the conduct of epidemiologic research. Each of these are related complex endeavors that build on the toxicologic evidence and extent of exposure. There is a need to assess the scientific basis and research needs for determining early functional changes, organ system and disease responses for use in targeted medical surveillance. There is also need for development of criteria for extrapolating toxicological data in biological systems to predict the risk of adverse outcomes in humans. In the meantime, exposure registries may be pivotal in helping societies act in the face of uncertainty in a precautionary manner, but legal, ethical, and logistical issues need resolution. Epidemiologic research will build on these efforts and may ultimately contribute critical definitive rationale for medical screening, risk assessment and management. JF - Toxicology AU - Trout, Douglas B AU - Schulte, Paul A AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA, PSchulte@cdc.gov Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 SP - 128 EP - 135 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 269 IS - 2-3 SN - 0300-483X, 0300-483X KW - Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Risk assessment KW - Inventories KW - Data processing KW - Organs KW - Nanotechnology KW - Risk management KW - Workers KW - Ethics KW - Priorities KW - Occupational exposure KW - nanotechnology KW - H 1000:Occupational Safety and Health KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746149843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Medical+surveillance%2C+exposure+registries%2C+and+epidemiologic+research+for+workers+exposed+to+nanomaterials&rft.au=Trout%2C+Douglas+B%3BSchulte%2C+Paul+A&rft.aulast=Trout&rft.aufirst=Douglas&rft.date=2010-03-10&rft.volume=269&rft.issue=2-3&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2009.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Number of references - 4 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inventories; Workers; Data processing; Ethics; Occupational exposure; nanotechnology; Risk management; Priorities; Organs; Nanotechnology DO - http://dx.doi.org/10.1016/j.tox.2009.12.006 ER - TY - JOUR T1 - Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. AN - 733805511; 19857541 AB - Carbon nanotubes (CNT) come in a variety of types, but one of the most common forms is multi-walled carbon nanotubes (MWCNT). MWCNT have potential applications in many diverse commercial processes, and thus human exposures are considered to be likely. In order to investigate the pulmonary toxicity of MWCNT, we conducted an in vivo dose-response and time course study of MWCNT in mice in order to assess their ability to induce pulmonary inflammation, damage, and fibrosis using doses that approximate estimated human occupational exposures. MWCNT were dispersed in dispersion medium (DM) and male C57BL/6J mice (7 weeks old) received either DM (vehicle control), 10, 20, 40 or 80mug MWCNT by aspiration exposure. At 1, 7, 28 and 56 days post-exposure, MWCNT-induced pulmonary toxicity was investigated. Bronchoalveolar lavage (BAL) studies determined pulmonary inflammation and damage was dose-dependent and peaked at 7 days post-exposure. By 56 days post-exposure, pulmonary inflammation and damage markers were returning to control levels, except for the 40mug MWCNT dose, which was still significantly higher than vehicle control. Histopathological studies determined that MWCNT exposure caused rapid development of pulmonary fibrosis by 7 days post-exposure, that granulomatous inflammation persisted throughout the 56-day post-exposure period, and also demonstrated that MWCNT can reach the pleura after pulmonary exposure. In summary, the data reported here indicate that MWCNT exposure rapidly produces significant adverse health outcomes in the lung. Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes. JF - Toxicology AU - Porter, Dale W AU - Hubbs, Ann F AU - Mercer, Robert R AU - Wu, Nianqiang AU - Wolfarth, Michael G AU - Sriram, Krishnan AU - Leonard, Stephen AU - Battelli, Lori AU - Schwegler-Berry, Diane AU - Friend, Sherry AU - Andrew, Michael AU - Chen, Bean T AU - Tsuruoka, Shuji AU - Endo, Morinobu AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. DPorter@cdc.gov Y1 - 2010/03/10/ PY - 2010 DA - 2010 Mar 10 SP - 136 EP - 147 VL - 269 IS - 2-3 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Toxicity Tests KW - Mice, Inbred C57BL KW - Mice KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Pneumonia -- chemically induced KW - Nanotubes, Carbon -- chemistry KW - Inhalation Exposure -- analysis KW - Nanotubes, Carbon -- ultrastructure KW - Lung -- ultrastructure KW - Lung -- drug effects KW - Lung -- pathology KW - Nanotubes, Carbon -- toxicity KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733805511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Mouse+pulmonary+dose-+and+time+course-responses+induced+by+exposure+to+multi-walled+carbon+nanotubes.&rft.au=Porter%2C+Dale+W%3BHubbs%2C+Ann+F%3BMercer%2C+Robert+R%3BWu%2C+Nianqiang%3BWolfarth%2C+Michael+G%3BSriram%2C+Krishnan%3BLeonard%2C+Stephen%3BBattelli%2C+Lori%3BSchwegler-Berry%2C+Diane%3BFriend%2C+Sherry%3BAndrew%2C+Michael%3BChen%2C+Bean+T%3BTsuruoka%2C+Shuji%3BEndo%2C+Morinobu%3BCastranova%2C+Vincent&rft.aulast=Porter&rft.aufirst=Dale&rft.date=2010-03-10&rft.volume=269&rft.issue=2-3&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2009.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-09 N1 - Date created - 2010-03-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.tox.2009.10.017 ER - TY - CPAPER T1 - Enteric virus detection and identification with a universal virus discovery assay T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742816294; 5700623 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Uhlenhaut, C AU - McClenahan, S AU - Sosnovtsev, S AU - Bok, K AU - Kapikian, A AU - Green, K AU - Krause, P Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742816294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Enteric+virus+detection+and+identification+with+a+universal+virus+discovery+assay&rft.au=Uhlenhaut%2C+C%3BMcClenahan%2C+S%3BSosnovtsev%2C+S%3BBok%2C+K%3BKapikian%2C+A%3BGreen%2C+K%3BKrause%2C+P&rft.aulast=Uhlenhaut&rft.aufirst=C&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Influenza vaccination: Where do we stand? T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742807790; 5700222 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Fiore, A Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Influenza KW - Vaccination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742807790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Influenza+vaccination%3A+Where+do+we+stand%3F&rft.au=Fiore%2C+A&rft.aulast=Fiore&rft.aufirst=A&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Incidence and trends of imported malaria in the Netherlands: 2000-2007 T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742806269; 5700258 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Van Rijckevorsel, G. AU - Sonder, G AU - Geskus, R AU - Den Hoek, Van AU - Van Genderen, J AU - Keuter, M AU - Ligthelm, R AU - Visser, L AU - Wetsteyn, J Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Netherlands KW - Malaria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742806269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Incidence+and+trends+of+imported+malaria+in+the+Netherlands%3A+2000-2007&rft.au=Van+Rijckevorsel%2C+G.%3BSonder%2C+G%3BGeskus%2C+R%3BDen+Hoek%2C+Van%3BVan+Genderen%2C+J%3BKeuter%2C+M%3BLigthelm%2C+R%3BVisser%2C+L%3BWetsteyn%2C+J&rft.aulast=Van+Rijckevorsel&rft.aufirst=G.&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Transfusion-associated Babesia infections: Reports received by the FDA 1997 to 2008 T2 - 14th International Congress on Infectious Diseases (ICID 2010) AN - 742804065; 5700452 JF - 14th International Congress on Infectious Diseases (ICID 2010) AU - Gubernot, D AU - Lee, K AU - Conley, G AU - Holness, L AU - O'callaghan, S AU - Cannon, S AU - Cowan, E AU - Nakhasi, H AU - Wise, R Y1 - 2010/03/09/ PY - 2010 DA - 2010 Mar 09 KW - Infection KW - FDA KW - Babesia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742804065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.atitle=Transfusion-associated+Babesia+infections%3A+Reports+received+by+the+FDA+1997+to+2008&rft.au=Gubernot%2C+D%3BLee%2C+K%3BConley%2C+G%3BHolness%2C+L%3BO%27callaghan%2C+S%3BCannon%2C+S%3BCowan%2C+E%3BNakhasi%2C+H%3BWise%2C+R&rft.aulast=Gubernot&rft.aufirst=D&rft.date=2010-03-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Congress+on+Infectious+Diseases+%28ICID+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.x-cd.com/isidmain2010/program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Exposure to Trauma in Children Served by Behavioral Health Services T2 - 23rd Annual Children's Mental Health Research & Policy Conference AN - 742829792; 5708036 JF - 23rd Annual Children's Mental Health Research & Policy Conference AU - Fisher, Sylvia Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Children KW - Trauma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742829792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.atitle=Exposure+to+Trauma+in+Children+Served+by+Behavioral+Health+Services&rft.au=Fisher%2C+Sylvia&rft.aulast=Fisher&rft.aufirst=Sylvia&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/CMHConference/zstuff/ConferenceAgenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Turning Data into Action: Using Data to Drive Service Programs T2 - 23rd Annual Children's Mental Health Research & Policy Conference AN - 742828496; 5707971 JF - 23rd Annual Children's Mental Health Research & Policy Conference AU - Yoe, James AU - Patrick, Douglas Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742828496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.atitle=Turning+Data+into+Action%3A+Using+Data+to+Drive+Service+Programs&rft.au=Yoe%2C+James%3BPatrick%2C+Douglas&rft.aulast=Yoe&rft.aufirst=James&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/CMHConference/zstuff/ConferenceAgenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Strategies for Using Psychopharmacology Data to Improve Quality of Care in Children's Mental Health: The Maine Experience T2 - 23rd Annual Children's Mental Health Research & Policy Conference AN - 742828336; 5707945 JF - 23rd Annual Children's Mental Health Research & Policy Conference AU - Yoe, James AU - Freeman, Elsie AU - Tweed, Lindsey Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - USA, Maine KW - Mental disorders KW - Children KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742828336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.atitle=Strategies+for+Using+Psychopharmacology+Data+to+Improve+Quality+of+Care+in+Children%27s+Mental+Health%3A+The+Maine+Experience&rft.au=Yoe%2C+James%3BFreeman%2C+Elsie%3BTweed%2C+Lindsey&rft.aulast=Yoe&rft.aufirst=James&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/CMHConference/zstuff/ConferenceAgenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Early Childhood Systems of Care: What Have We Learned? What Are the Next Steps? T2 - 23rd Annual Children's Mental Health Research & Policy Conference AN - 742826927; 5708008 JF - 23rd Annual Children's Mental Health Research & Policy Conference AU - Fisher, Sylvia Y1 - 2010/03/07/ PY - 2010 DA - 2010 Mar 07 KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742826927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.atitle=Early+Childhood+Systems+of+Care%3A+What+Have+We+Learned%3F+What+Are+the+Next+Steps%3F&rft.au=Fisher%2C+Sylvia&rft.aulast=Fisher&rft.aufirst=Sylvia&rft.date=2010-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Children%27s+Mental+Health+Research+%26+Policy+Conference&rft.issn=&rft_id=info:doi/ L2 - http://rtckids.fmhi.usf.edu/CMHConference/zstuff/ConferenceAgenda.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - What Are the New Requirements for Post-Marketing Trials for Safety and Efficacy? T2 - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AN - 42327821; 5652190 JF - 12th Annual Meeting of the American Society for Experimental Neuro Therapeutic AU - Marinac-Dabic, Danica Y1 - 2010/03/04/ PY - 2010 DA - 2010 Mar 04 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42327821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.atitle=What+Are+the+New+Requirements+for+Post-Marketing+Trials+for+Safety+and+Efficacy%3F&rft.au=Marinac-Dabic%2C+Danica&rft.aulast=Marinac-Dabic&rft.aufirst=Danica&rft.date=2010-03-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+the+American+Society+for+Experimental+Neuro+Therapeutic&rft.issn=&rft_id=info:doi/ L2 - http://asent.org/download.cfm?downloadfile=26A4645A-7E94-EA9B-8E5289E1 AD48EC8D&typename=dmFile&fieldname=filename LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Osmotic cavitation of elastomeric intraocular lenses AN - 918055385; 16181770 AB - In recent years, traditional rigid materials have been replaced with softer elastomers in intraocular lenses to minimize the size of the required surgical incision, thereby reducing patient recuperation time. However, water-filled cavities that may impact visual acuity are found in many of these new implants. We demonstrate that the cavitation observed in vivo can occur due to an osmotic pressure difference between the aqueous solution within the cavity and the external media in which the lens is immersed. By reducing the osmolarity of the external solution from 300 to 0 mM, we observe an increase in cavity volume of almost a factor of 30. Further, we have developed a model for cavity growth assuming the controlling factor is diffusion of hydrophilic molecules from the polymer matrix into the cavity. We find that the experimental observations are consistent with the model and suggest that oligomeric species generated during polymerization are responsible for the observed cavitation. JF - Acta Biomaterialia AU - Saylor, David M AU - Richardson, DColeman AU - Dair, Benita J AU - Pollack, Steven K AD - Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA, david.saylor@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1090 EP - 1098 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 6 IS - 3 SN - 1742-7061, 1742-7061 KW - Biotechnology and Bioengineering Abstracts KW - Intraocular lens (IOL) KW - Elastomer KW - Diffusion KW - Osmotic pressure KW - Cavitation KW - Cavities KW - Molecular modelling KW - Polymerization KW - Acuity KW - osmolarity KW - Elastomers KW - Models KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/918055385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Biomaterialia&rft.atitle=Osmotic+cavitation+of+elastomeric+intraocular+lenses&rft.au=Saylor%2C+David+M%3BRichardson%2C+DColeman%3BDair%2C+Benita+J%3BPollack%2C+Steven+K&rft.aulast=Saylor&rft.aufirst=David&rft.date=2010-03-01&rft.volume=6&rft.issue=3&rft.spage=1090&rft.isbn=&rft.btitle=&rft.title=Acta+Biomaterialia&rft.issn=17427061&rft_id=info:doi/10.1016%2Fj.actbio.2009.08.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Cavities; Polymerization; Cavitation; Acuity; Diffusion; osmolarity; Osmotic pressure; Elastomers; Models DO - http://dx.doi.org/10.1016/j.actbio.2009.08.030 ER - TY - JOUR T1 - Sequencing analysis of mutations induced by N-ethyl-N-nitrosourea at different sampling times in mouse bone marrow AN - 883026347; 15242006 AB - In our previous study (Wang et al., 2004, Toxicol. Sci. 82: 124-128), we observed that the cII gene mutant frequency (MF) in the bone marrow of Big Blue mice showed significant increase as early as day 1, reached the maximum at day 3 and then decreased to a plateau by day 15 after a single dose of carcinogen N-ethyl-N-nitrosourea (ENU) treatment, which is different from the longer mutation manifestation time and the constancy of MFs after reaching their maximum in some other tissues. To determine the mechanism underlying the quick increase in MF and the peak formation in the mutant manifestation, we examined the mutation frequencies and spectra of the ENU-induced mutants collected from different sampling times in this study. The cII mutants from days 1, 3 and 120 after ENU treatment were randomly selected from different animals. The mutation frequencies were 33, 217, 305 and 144 10-6 for control, days 1, 3, and 120, respectively. The mutation spectra at days 1 and 3 were significantly different from that at day 120. Considering that stem cells are responsible for the ultimate MF plateau (day 120) and transit cells are accountable for the earlier MF induction (days 1 or 3) in mouse bone marrow, we conclude that transit cells are much more sensitive to mutation induction than stem cells in mouse bone marrow, which resulted in the specific mutation manifestation induced by ENU. Published in 2009 by John Wiley & Sons, Ltd. JF - Journal of Applied Toxicology AU - Wang, Jianyong AU - Chen, Tao Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 133 EP - 141 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 2 SN - 1099-1263, 1099-1263 KW - Environment Abstracts; Toxicology Abstracts KW - Bone marrow KW - Mice KW - Mutant frequency KW - Carcinogens KW - Mutants KW - plateaus KW - Stem cells KW - stem cells KW - Ethyl nitrosourea KW - Gene frequency KW - Sampling KW - Mutation KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883026347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Sequencing+analysis+of+mutations+induced+by+N-ethyl-N-nitrosourea+at+different+sampling+times+in+mouse+bone+marrow&rft.au=Wang%2C+Jianyong%3BChen%2C+Tao&rft.aulast=Wang&rft.aufirst=Jianyong&rft.date=2010-03-01&rft.volume=30&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=10991263&rft_id=info:doi/10.1002%2Fjat.1479 L2 - http://onlinelibrary.wiley.com/doi/10.1002/jat.1479/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Stem cells; Bone marrow; Ethyl nitrosourea; Gene frequency; Mutant frequency; Carcinogens; Sampling; Mutation; plateaus; stem cells; Mice; Mutants DO - http://dx.doi.org/10.1002/jat.1479 ER - TY - JOUR T1 - Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs AN - 877568506; 13016156 AB - The drug development of new anti-cancer agents is streamlined in response to the urgency of bringing effective drugs to market for patients with limited life expectancy. FDA's regulation of oncology drugs has evolved from the practices set forth in Arnold Lehman's seminal work published in the 1950s through the current drafting of a new International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) safety guidance for anti-cancer drug nonclinical evaluations. The ICH combines the efforts of the regulatory authorities of Europe, Japan, and the United States and the pharmaceutical industry from these three regions to streamline the scientific and technical aspects of drug development. The recent development of new oncology drug classes with novel mechanisms of action has improved survival rates for some cancers but also brings new challenges for safety evaluation. Here we present the legacy of Lehman and colleagues in the context of past and present oncology drug development practices and focus on some of the current issues at the center of an evolving harmonization process that will generate a new safety guidance for oncology drugs, ICH S9. The purpose of this new guidance will be to facilitate oncology drug development on a global scale by standardizing regional safety requirements. JF - Toxicology and Applied Pharmacology AU - Rosenfeldt, Hans AU - Kropp, Timothy AU - Benson, Kimberly AU - Ricci, MStacey AU - McGuinn, WDavid AU - Verbois, SLeigh AD - Division of Drug Oncology Products, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring MD, 20993, USA Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 125 EP - 133 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 243 IS - 2 SN - 0041-008X, 0041-008X KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts KW - Cancer KW - Drug development KW - X 24310:Pharmaceuticals KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877568506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Regulatory+aspects+of+oncology+drug+safety+evaluation%3A+Past+practice%2C+current+issues%2C+and+the+challenge+of+new+drugs&rft.au=Rosenfeldt%2C+Hans%3BKropp%2C+Timothy%3BBenson%2C+Kimberly%3BRicci%2C+MStacey%3BMcGuinn%2C+WDavid%3BVerbois%2C+SLeigh&rft.aulast=Rosenfeldt&rft.aufirst=Hans&rft.date=2010-03-01&rft.volume=243&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.12.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drug development DO - http://dx.doi.org/10.1016/j.taap.2009.12.020 ER - TY - JOUR T1 - Occupational exposure to naturally occurring asbestos (NOA) AN - 762674537; 2010-092645 AB - Asbestos occurs naturally through geologic processes and can be found throughout much of the world. It is clear that mining of asbestos, the manufacture of asbestos products and the use of asbestos products has been associated with disease. There is some suggestion that working with asbestos containing rocks and soils may also have contributed to disease. Concerns have been raised in populations that have encountered naturally occurring asbestos (NOA) in their local environment. The situation is further complicated by controversies regarding the toxicity of other fibrous minerals or fragments of non-asbestiform varieties of asbestos minerals. Mining and quarrying are local sources of dust that may contain asbestos or other elongate mineral particles, but less obvious commercial activities, such as construction and farming, and even some recreational activities, can also result in exposures and thus potential risks for disease. Communities traditionally have had to come to terms with their local environment and its potential hazards to health, especially when acute and well-known, such as flooding or earthquake. However, a more complex relationship can occur with more insidious and long-term risks. NOA has implications for amenity use and property values, as well as health, and this can also result in social and political stress within a community. In addition, the process of risk communication and management can be muddled by uncertainties and conflicts of interests as well as by differences in perception and acceptance of risk. Asbestos and related minerals are commonly encountered in the mountain ranges in the both the east and west sides of the North American continent. As populations extend into these areas, NOA will be increasingly encountered. Occupational risks to miners and quarrymen and also construction workers and farmers need to be assessed and, where necessary, controlled. However, there are also potential risks to others outside of these specific occupations. Therefore, occupational hygiene professionals, including toxicologists, epidemiologists and risk assessors, work together with geologists and environmentalists to ensure a holistic approach to the issues of NOA. JF - Abstracts with Programs - Geological Society of America AU - Harper, Martin AU - Anonymous Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 77 PB - Geological Society of America (GSA), Boulder, CO VL - 42 IS - 1 SN - 0016-7592, 0016-7592 KW - silicates KW - mining KW - medical geology KW - asbestos KW - pollutants KW - natural materials KW - pollution KW - risk assessment KW - diseases KW - public health KW - human ecology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762674537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Occupational+exposure+to+naturally+occurring+asbestos+%28NOA%29&rft.au=Harper%2C+Martin%3BAnonymous&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2010-03-01&rft.volume=42&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Northeastern Section, 45th annual meeting Geological Society of America, Southeastern Section, 59th annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2010-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - asbestos; diseases; human ecology; medical geology; mining; natural materials; pollutants; pollution; public health; risk assessment; silicates ER - TY - JOUR T1 - New Probit equations for the calculation of thermal effects on humans AN - 753738356; 12971209 AB - In this paper new Probit equations are proposed to estimate damage produced by thermal radiation on humans (for first- and second-degree burns). They are compared to empirical threshold values and also to existing Probit equations. Results obtained are in good agreement with previous empirical experience. They also provide better estimations than existing equations. When an analysis is performed to study the evolution in the percentage of affected people by different degrees of damages, results show that proposed equations produce more consistent results than existing equations. JF - Process Safety and Environmental Protection AU - Perez, Juan Francisco Sanchez AU - Ferradas, Enrique Gonzalez AU - Alonso, Fernando Diaz AU - Garcia, Daniel Palacios AU - Cano, Maria Victoria Minguez AU - Cotorruelo, Jose Angel Bautista AD - Department of Health, Directorate General of Public Health - Service for Environmental Health, Murcia, Spain Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 109 EP - 113 PB - Institution of Chemical Engineers, Davis Bldg. Rugby Warwickshire CV21 3HQ United Kingdom VL - 88 IS - 2 SN - 0957-5820, 0957-5820 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753738356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+and+Environmental+Protection&rft.atitle=New+Probit+equations+for+the+calculation+of+thermal+effects+on+humans&rft.au=Perez%2C+Juan+Francisco+Sanchez%3BFerradas%2C+Enrique+Gonzalez%3BAlonso%2C+Fernando+Diaz%3BGarcia%2C+Daniel+Palacios%3BCano%2C+Maria+Victoria+Minguez%3BCotorruelo%2C+Jose+Angel+Bautista&rft.aulast=Perez&rft.aufirst=Juan+Francisco&rft.date=2010-03-01&rft.volume=88&rft.issue=2&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Process+Safety+and+Environmental+Protection&rft.issn=09575820&rft_id=info:doi/10.1016%2Fj.psep.2009.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-11-14 DO - http://dx.doi.org/10.1016/j.psep.2009.11.007 ER - TY - JOUR T1 - Detection of hazelnuts and almonds using commercial ELISA test kits AN - 753695010; 13324471 AB - Abstract not available. JF - Analytical and Bioanalytical Chemistry AU - Garber, Eric A E AU - Perry, Jesse AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA, Eric.Garber@fda.hhs.gov PY - 2010 SP - 1939 EP - 1945 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 396 IS - 5 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Testing Procedures KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753695010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Detection+of+hazelnuts+and+almonds+using+commercial+ELISA+test+kits&rft.au=Garber%2C+Eric+A+E%3BPerry%2C+Jesse&rft.aulast=Garber&rft.aufirst=Eric+A&rft.date=2010-03-01&rft.volume=396&rft.issue=5&rft.spage=1939&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-009-3424-2 L2 - http://www.springerlink.com/content/nm014l2l82408v56/?p=125754fc9893485187cc2cb3cab0dc24&pi=34 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Testing Procedures DO - http://dx.doi.org/10.1007/s00216-009-3424-2 ER - TY - JOUR T1 - Changing Farm Injury Trends by Sex for Youth Living on US Farms, 1998-2006 AN - 746226876; 12799075 AB - AbstractPurpose: To estimate the number and rate of on-farm injuries to youth living on farms in the United States by sex from 1998 to 2006 and compare the trends in youth injury by sex.Methods: Data from 4 childhood agricultural injury surveys for the years 1998, 2001, 2004, and 2006 were analyzed using a Poisson regression model utilizing generalized estimating equations. Rate ratios with corresponding 95% confidence intervals were calculated from the model, which compared the estimated rates of injury in 2001, 2004, and 2006 to the estimated rate of injury in the baseline year, 1998.Results: There was an overall decline in the estimated number and rate of injuries to youth living on farms from 1998 to 2006, with a linear decline of the rate ratios for all youth on farms that was found to be significant. By sex, the trend in injury rate ratios for male youth significantly declined, while the trend for female youth for the same time period initially increased then returned to the baseline. Nonhomogeneity in trends by age group, work versus nonwork injury, and source of injury was also identified.Conclusion: Additional surveillance is needed to determine if injury trends to youth living on farms will continue to differ by sex. More detailed data on exposure to hazards for these youth by sex are needed to determine what factors are associated with these disparate injury trends and to design and implement effective interventions to further reduce injuries to youth living on farms. JF - Journal of Rural Health AU - Hendricks, Kitty J AU - Hendricks, Scott A AD - 1Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 182 EP - 188 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 26 IS - 2 SN - 0890-765X, 0890-765X KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Injuries KW - Children KW - USA KW - farms KW - intervention KW - Rural areas KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746226876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rural+Health&rft.atitle=Changing+Farm+Injury+Trends+by+Sex+for+Youth+Living+on+US+Farms%2C+1998-2006&rft.au=Hendricks%2C+Kitty+J%3BHendricks%2C+Scott+A&rft.aulast=Hendricks&rft.aufirst=Kitty&rft.date=2010-03-01&rft.volume=26&rft.issue=2&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2010.00280.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Injuries; intervention; farms; Children; Rural areas; USA DO - http://dx.doi.org/10.1111/j.1748-0361.2010.00280.x ER - TY - JOUR T1 - Postaccident Mine Communications and Tracking Systems AN - 746149074; 12935783 AB - Recent mine disasters in the U.S. exposed various inadequacies and gaps in mine-safety technology. Congress responded to these tragedies by enacting the Mine Improvement and New Emergency Response Act of 2006 (MINER Act), which resulted in the most significant change to mine-safety laws in 30 years. To help meet the requirements of the MINER Act and to help eliminate future tragedies, the National Institute for Occupational Safety and Health initiated aggressive research programs for developing new, and enhancing existing, mine-safety technologies. A major research emphasis addressed the lack of postaccident communications, which surfaced as a critical deficiency in some disasters. As a result, three communications approaches emerged as viable technologies-enhanced leaky-feeder, wireless-mesh, and medium-frequency systems. This paper describes the operation, application, advantages, and disadvantages of each system, as well as the challenges associated with underground wireless communications. JF - IEEE Transactions on Industry Applications AU - Novak, Thomas AU - Snyder, David P AU - Kohler, Jeffery L AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, PA, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 712 EP - 719 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 46 IS - 2 SN - 0093-9994, 0093-9994 KW - Health & Safety Science Abstracts KW - USA KW - Communications KW - Emergency preparedness KW - Congress KW - Occupational safety KW - Disasters KW - Mining KW - Mines KW - Research programs KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746149074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Industry+Applications&rft.atitle=Postaccident+Mine+Communications+and+Tracking+Systems&rft.au=Novak%2C+Thomas%3BSnyder%2C+David+P%3BKohler%2C+Jeffery+L&rft.aulast=Novak&rft.aufirst=Thomas&rft.date=2010-03-01&rft.volume=46&rft.issue=2&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Industry+Applications&rft.issn=00939994&rft_id=info:doi/10.1109%2FTIA.2010.2040059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Communications; Congress; Emergency preparedness; Occupational safety; Disasters; Mining; Mines; Research programs; Technology; USA DO - http://dx.doi.org/10.1109/TIA.2010.2040059 ER - TY - JOUR T1 - Transcriptional responses to oxidative stress: Pathological and toxicological implications AN - 746080388; 12971435 AB - The utilization of molecular oxygen as the terminal electron acceptor for energy production has in many ways shaped the evolution of complex life, physiology, and certain disease processes. The generation of reactive oxygen species (ROS), either as by-products of O sub(2) metabolism or by specialized enzymes, has the potential to damage cellular components and functions. Exposure to a variety of exogenous toxicants also promotes ROS production directly or through indirect means to cause toxicity. Oxidative stress activates the expression of a wide range of genes that mediate the pathogenic effect of ROS or are required for the detection and detoxification of the oxidants. In many cases, these are mediated by specific transcription factors whose expression, structure, stability, nuclear targeting, or DNA-binding affinity is regulated by the level of oxidative stress. This review examines major transcription factors that mediate transcriptional responses to oxidative stress, focusing on recent progress in the signaling pathways and mechanisms of activation of transcription factors by oxidative stress and the implications of this regulation in the development of disease and chemical toxicity. JF - Pharmacology & Therapeutics AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, United States, qam1@cdc.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 376 EP - 393 PB - Elsevier Science, Box 882 New York NY 10159 USA VL - 125 IS - 3 SN - 0163-7258, 0163-7258 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Detoxification KW - Oxidative stress KW - N 14835:Protein-Nucleic Acids Association KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746080388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+Therapeutics&rft.atitle=Transcriptional+responses+to+oxidative+stress%3A+Pathological+and+toxicological+implications&rft.au=Ma%2C+Qiang&rft.aulast=Ma&rft.aufirst=Qiang&rft.date=2010-03-01&rft.volume=125&rft.issue=3&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+Therapeutics&rft.issn=01637258&rft_id=info:doi/10.1016%2Fj.pharmthera.2009.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Oxidative stress DO - http://dx.doi.org/10.1016/j.pharmthera.2009.11.004 ER - TY - JOUR T1 - Influence of artificial gastric juice composition on bioaccessibility of cobalt- and tungsten-containing powders AN - 746077666; 12972311 AB - The dissolution of metal-containing particles in the gastric compartment is poorly understood. The purpose of this study was to elucidate the influence of artificial gastric juice chemical composition on bioaccessibility of metals associated with ingestion-based health concerns. Dissolution rates were evaluated for well-characterized feedstock cobalt, tungsten metal, and tungsten carbide powders, chemically bonded pre-sintered (spray dryer material) and post-sintered (chamfer grinder) cemented tungsten carbide materials, and an admixture of pure cobalt and pure tungsten carbide, prepared by mechanically blending the two feedstock powders. Dissolution of each study material was evaluated in three different formulations of artificial gastric juice (from simplest to most chemically complex): American Society of Testing Materials (ASTM), U.S. Pharmacopoeia (USP), and National Institute for Occupational Safety and Health (NIOSH). Approximately 20% of cobalt dissolved in the first dissolution phase (t sub(1/2) = 0.02 days) and the remaining 80% was released in the second long-term dissolution phase (t sub(1/2) = 0.5 to 1 days). Artificial gastric juice chemical composition did not influence dissolution rate constant values (k, g/cm super(2) day) of cobalt powder, either alone or as an admixture. Approximately 100% of the tungsten and tungsten carbide that dissolved was released in a single dissolution phase; k-values of each material differed significantly in the solvents: NIOSH > ASTM > USP (p<0.05). The k-values of cobalt and tungsten carbide in pre- and post-sintered cemented tungsten carbide powders were significantly different from values for the pure feedstock powders. Solvent composition had little influence on oral bioaccessibility of highly soluble cobalt and our data support consideration of the oral exposure route as a contributing pathway to total-body exposure. Solvent composition appeared to influence bioaccessibility of the low soluble tungsten compounds, though differences may be due to variability in the data associated with the small masses of materials that dissolved. Nonetheless, ingestion exposure may not contribute appreciably to total body burden given the short residence time of material in the stomach and relatively long dissolution half-times of these materials (t sub(1/2) = 60 to 380 days). JF - International Journal of Hygiene and Environmental Health AU - Stefaniak, Aleksandr B AU - Virji, MAbbas AU - Harvey, Christopher J AU - Sbarra, Deborah C AU - Day, Gregory A AU - Hoover, Mark D AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H-2703, Morgantown, WV 26505, USA, astefaniak@cdc.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 107 EP - 115 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany VL - 213 IS - 2 SN - 1438-4639, 1438-4639 KW - Environment Abstracts KW - Dissolution KW - Gastric juice KW - Ingestion KW - Cobalt KW - Cemented tungsten carbide KW - Metals KW - Chemical composition KW - Tungsten compounds KW - Sprays KW - Solvents KW - Particulates KW - Tungsten KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746077666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Hygiene+and+Environmental+Health&rft.atitle=Influence+of+artificial+gastric+juice+composition+on+bioaccessibility+of+cobalt-+and+tungsten-containing+powders&rft.au=Stefaniak%2C+Aleksandr+B%3BVirji%2C+MAbbas%3BHarvey%2C+Christopher+J%3BSbarra%2C+Deborah+C%3BDay%2C+Gregory+A%3BHoover%2C+Mark+D&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2010-03-01&rft.volume=213&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Hygiene+and+Environmental+Health&rft.issn=14384639&rft_id=info:doi/10.1016%2Fj.ijheh.2009.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Metals; Chemical composition; Tungsten compounds; Cobalt; Sprays; Solvents; Particulates; Ingestion; Tungsten DO - http://dx.doi.org/10.1016/j.ijheh.2009.12.006 ER - TY - JOUR T1 - DIRECT FIBROGENIC EFFECTS OF DISPERSED SINGLE-WALLED CARBON NANOTUBES ON HUMAN LUNG FIBROBLASTS AN - 746005162; 12758949 AB - Nanomaterials, including single-walled carbon nanotubes (SWCNT), are being developed for a variety of commercial products. However, adverse health effects attributed to these new materials are not well understood. Recent reports showed that exposure of mice to dispersed SWCNT (DSWCNT) produced a rapid and progressive interstitial lung fibrosis without persistent inflammation. To understand the mechanism underlying this unusual fibrogenicity of DSWCNT, the present investigation focused on the direct bioactivity of DSWCNT using a cell culture of lung fibroblasts that represent a major cell type resident in the lung interstitium and responsible for the production of collagen matrix. At concentrations relevant to those used in vivo, in vitro exposure of lung fibroblasts to DSWCNT stimulated cell proliferation and induced collagen production without producing cell damage. One of the major matrix metalloproteinases (MMP), MMP-9, which is known to be involved in lung fibrosis, was also elevated by DSWCNT treatment both in vitro and in vivo. Taken together, these results suggest that direct stimulation of fibroblasts by DSWCNT translocated into the interstitium may play a significant role in DSWCNT-induced lung fibrosis. Our data also suggest that the dispersion status and/or size of the SWCNT structures is a critical factor in determining nanoparticle fibrogenicity and that MMP-9 may be involved in the fibrogenic process. The results obtained may aid in the development of in vitro models for rapid screening of the potential fibrogenicity of carbon nanotubes, which are lacking and urgently needed. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Wang, Liying AU - Mercer, Robert R AU - Rojanasakul, Yon AU - Qiu, Aijun AU - Lu, Yongju AU - Scabilloni, James F AU - Wu, Nianqiang AU - Castranova, Vincent AD - National Institute for Occupational Safety and Health, HELD/PPRB, Morgantown, West Virginia Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 410 EP - 422 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 73 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Environment Abstracts; Toxicology Abstracts KW - Data processing KW - Fibrosis KW - Matrix metalloproteinase KW - Mice KW - Cell culture KW - Inflammation KW - Collagen KW - Fibroblasts KW - Carbon KW - Lung KW - nanotubes KW - Gelatinase B KW - Cell proliferation KW - nanoparticles KW - nanotechnology KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746005162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=DIRECT+FIBROGENIC+EFFECTS+OF+DISPERSED+SINGLE-WALLED+CARBON+NANOTUBES+ON+HUMAN+LUNG+FIBROBLASTS&rft.au=Wang%2C+Liying%3BMercer%2C+Robert+R%3BRojanasakul%2C+Yon%3BQiu%2C+Aijun%3BLu%2C+Yongju%3BScabilloni%2C+James+F%3BWu%2C+Nianqiang%3BCastranova%2C+Vincent&rft.aulast=Wang&rft.aufirst=Liying&rft.date=2010-03-01&rft.volume=73&rft.issue=5-6&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390903486550 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Data processing; Fibrosis; Matrix metalloproteinase; Cell culture; Fibroblasts; Collagen; Inflammation; Carbon; Lung; nanotubes; Gelatinase B; Cell proliferation; nanoparticles; nanotechnology; Mice DO - http://dx.doi.org/10.1080/15287390903486550 ER - TY - JOUR T1 - SINGLE- AND MULTI-WALL CARBON NANOTUBES VERSUS ASBESTOS: ARE THE CARBON NANOTUBES A NEW HEALTH RISK TO HUMANS? AN - 746004289; 12758947 AB - Carbon nanotubes (CNT), since their discovery, have become one of the most promising nanomaterials in many industrial and biomedical applications. Due to their unique physico-chemical properties, interest is growing in the manufacture of CNT-based products and their subsequent marketing. Since their discovery, the prospect of possible undesirable human health effects has been a focus of many scientific studies. Although CNT possess unique physical properties that include (1) nanoscale diameter, (2) a wide length distribution ranging from tens of nanometers to several micrometers, and (3) high aspect ratio, the fibrous-like shape and durability suggest that their toxic properties may be analogous to those observed with other fibrous particles, such as asbestos. The present study provides a summary of published findings on CNT bioactivity, such as the potential of CNT, especially of multi-wall carbon nanotubes (MWCNT), to activate signaling pathways modulating transcription factor activity, induce apoptosis, induce DNA damage, and initiate biological responses. Assessment of risks to human health and adoption of appropriate exposure controls is critical for the safe and successful introduction of CNT -based products for future applications. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Pacurari, Markka AU - Castranova, Vince AU - Vallyathan, Val AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 378 EP - 395 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 73 IS - 5-6 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts; Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Risk assessment KW - Asbestos KW - Apoptosis KW - marketing KW - Physicochemical properties KW - Adoption KW - Particulates KW - Nanotechnology KW - DNA damage KW - Carbon KW - Transcription factors KW - DNA KW - Marketing KW - nanotubes KW - nanotechnology KW - Signal transduction KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746004289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=SINGLE-+AND+MULTI-WALL+CARBON+NANOTUBES+VERSUS+ASBESTOS%3A+ARE+THE+CARBON+NANOTUBES+A+NEW+HEALTH+RISK+TO+HUMANS%3F&rft.au=Pacurari%2C+Markka%3BCastranova%2C+Vince%3BVallyathan%2C+Val&rft.aulast=Pacurari&rft.aufirst=Markka&rft.date=2010-03-01&rft.volume=73&rft.issue=5-6&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287390903486527 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Risk assessment; DNA damage; Asbestos; Apoptosis; Carbon; Transcription factors; Physicochemical properties; nanotubes; Adoption; Signal transduction; nanotechnology; marketing; Marketing; DNA; Particulates; Nanotechnology DO - http://dx.doi.org/10.1080/15287390903486527 ER - TY - JOUR T1 - Therapeutic potential of the immunomodulatory activities of adult mesenchymal stem cells AN - 745977527; 12744876 AB - Adult mesenchymal stem cells (MSCs) include a select population of resident cells within adult tissues, which retain the ability to differentiate along several tissue-specific lineages under defined media conditions and have finite expansion potential in vitro. These adult progenitor populations have been identified in various tissues, but it remains unclear exactly what role both transplanted and native MSCs play in processes of disease and regeneration. Interestingly, increasing evidence reveals a unique antiinflammatory immunomodulatory phenotype shared among this population, lending support to the idea that MSCs play a central role in early tissue remodeling responses where a controlled inflammatory response is required. However, additional evidence suggests that MSCs may not retain infinite immune privilege and that the context with which these cells are introduced in vivo may influence their immune phenotype. Therefore, understanding this dynamic microenvironment in which MSCs participate in complex feedback loops acting upon and being influenced by a plethora of secreted cytokines, extracellular matrix molecules, and fragments will be critical to elucidating the role of MSCs in the intertwined processes of immunomodulation and tissue repair. Birth Defects Research (Part C) 90:67-74, 2010. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Aronin, Caren E Petrie AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, rst13@pitt.edu Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 67 EP - 74 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 90 IS - 1 SN - 1542-975X, 1542-975X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - Extracellular matrix KW - Congenital defects KW - Cytokines KW - Microenvironments KW - Embryos KW - Feedback KW - Mesenchyme KW - Immunomodulation KW - Inflammation KW - Immune privilege KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745977527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Therapeutic+potential+of+the+immunomodulatory+activities+of+adult+mesenchymal+stem+cells&rft.au=Aronin%2C+Caren+E+Petrie%3BTuan%2C+Rocky+S&rft.aulast=Aronin&rft.aufirst=Caren+E&rft.date=2010-03-01&rft.volume=90&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20174 L2 - http://www3.interscience.wiley.com/journal/123324741/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Stem cells; Extracellular matrix; Microenvironments; Cytokines; Congenital defects; Feedback; Embryos; Mesenchyme; Immunomodulation; Immune privilege; Inflammation DO - http://dx.doi.org/10.1002/bdrc.20174 ER - TY - JOUR T1 - Cytotoxicity and mutagenicity of retinol with ultraviolet A irradiation in mouse lymphoma cells AN - 745928452; 13019676 AB - Vitamin A (all-trans-retinol; retinol) is an essential human nutrient and plays an important role in several biological functions. However, under certain circumstances, retinol treatment can cause free radical generation and induce oxidative stress. In this study, we investigated photocytotoxicity and photomutagenicity of retinol using L5178Y/Tk +/a mouse lymphoma cells concomitantly exposed to retinol and ultraviolet A (UVA) light. While the cells treated with retinol alone at the doses of 5 or 10I14g/ml in the absence of light did not increase the mutant frequency (MF) in the Tk gene, the treatment of the cells with 1-4I14g/ml retinol under UVA light (1.38mW/cm2 for 30min) increased the MF in the Tk gene in a dose-responsive manner. To elucidate the underlying mechanism of action, we also examined the mutational types of the Tk mutants by determining their loss of heterozygosity (LOH) at four microsatellite loci spanning the entire chromosome 11 on which the Tk gene is located. The mutational spectrum for the retinol+UVA treatment was significantly different from those of the control and UVA alone. More than 93% of the mutants from retinol+UVA treatment lost heterozygosity at the Tk1 locus and the major type (58%) of mutations was LOHs extending to D11Mit42, an alternation involving approximately 6cM of the chromosome, whereas the main type of mutations in the control was non-LOH mutations. These results suggest that retinol is mutagenic when exposed to UVA in mouse lymphoma cells through a clastogenic mode-of-action. JF - Toxicology In Vitro AU - Mei, Nan AU - Hu, Jiaxiang AU - Xia, Qingsu AU - Fu, Peter P AU - Moore, Martha M AU - Chen, Tao AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 439 EP - 444 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 24 IS - 2 SN - 0887-2333, 0887-2333 KW - Immunology Abstracts; Toxicology Abstracts KW - Chromosomes KW - Vitamin A KW - X 24390:Radioactive Materials KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745928452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+In+Vitro&rft.atitle=Cytotoxicity+and+mutagenicity+of+retinol+with+ultraviolet+A+irradiation+in+mouse+lymphoma+cells&rft.au=Mei%2C+Nan%3BHu%2C+Jiaxiang%3BXia%2C+Qingsu%3BFu%2C+Peter+P%3BMoore%2C+Martha+M%3BChen%2C+Tao&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2010-03-01&rft.volume=24&rft.issue=2&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Toxicology+In+Vitro&rft.issn=08872333&rft_id=info:doi/10.1016%2Fj.tiv.2009.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Vitamin A DO - http://dx.doi.org/10.1016/j.tiv.2009.10.004 ER - TY - JOUR T1 - Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats AN - 745641931; 13159376 AB - A modified flow cytometry assay for Pig-A mutant rat red blood cells (RBCs) was developed using an antibody that positively identifies rat RBCs (monoclonal antibody HIS49). The assay was used in conjunction with a flow cytometric micronucleus (MN) assay to evaluate gene mutation and clastogenicity/aneugenicity in adolescent male and female rats treated with methylphenidate hydrochloride (MPH). Sprague-Dawley rats were treated orally with 3 mg/kg MPH (70/sex) or water (40/sex) 3 X /day on postnatal days (PNDs) 29-50. Eight additional rats (4/sex) were injected i.p. with N-ethyl-N-nitrosourea (ENU) on PND 28. Blood was collected on PNDs 29, 50, and 90, and used for determining serum MPH levels and/or conducting genotoxicity assays. On the first and last days of MPH treatment (PNDs 29 and 50), serum MPH levels averaged 21 pg/l, well within the clinical treatment range. Relative to our previously published method (Miura et al. [2008]; Environ Mol Mutagen 49: 614-629), the HIS49 Pig-A mutation assay significantly reduced the background RBC mutant frequency; in the experiments with ENU-treated rats, the modification increased the overall sensitivity of the assay 2-3 fold. Even with the increased assay sensitivity, the 21 consecutive days of MPH treatment produced no evidence of Pig-A mutation induction (measured at PND 90); in addition, MPH treatment did not increase MN frequency (measured at PND 50). These results support the consensus view that the genotoxicity of MPH in pediatric patients reported earlier (El-Zein et al. [2005]: Cancer Lett 230: 284-291) cannot be reproduced in animal models, suggesting that MPH at clinically relevant levels may be nongenotoxic in humans. Environ. Mol. Mutagen. 2010. Published 2009 by Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Dobrovolsky, Vasily N AU - Boctor, Sherin Y AU - Twaddle, Nathan C AU - Doerge, Daniel R AU - Bishop, Michelle E AU - Manjanatha, Mugimane G AU - Kimoto, Takafumi AU - Miura, Daishiro AU - Heflich, Robert H AU - Ferguson, Sherry A AD - Division of Genetic and Reproductive Toxicology; National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas, Vasily.Dobrovolsky@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 138 EP - 145 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 2 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts KW - Mutagens KW - Erythrocytes KW - Animal models KW - Methylphenidate KW - Mutant frequency KW - Mutants KW - Mutagenesis KW - Rats KW - Flow cytometry KW - Ethyl nitrosourea KW - Manganese KW - Adolescents KW - Sex KW - Sensitivity KW - Monoclonal antibodies KW - Pediatrics KW - Adolescence KW - Genotoxicity KW - Point mutation KW - Japan, Honshu, Kanagawa Prefect., Miura Peninsula, Miura KW - Cancer KW - Clastogenicity KW - Mutation KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745641931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Flow+cytometric+detection+of+Pig-A+mutant+red+blood+cells+using+an+erythroid-specific+antibody%3A+Application+of+the+method+for+evaluating+the+in+vivo+genotoxicity+of+methylphenidate+in+adolescent+rats&rft.au=Dobrovolsky%2C+Vasily+N%3BBoctor%2C+Sherin+Y%3BTwaddle%2C+Nathan+C%3BDoerge%2C+Daniel+R%3BBishop%2C+Michelle+E%3BManjanatha%2C+Mugimane+G%3BKimoto%2C+Takafumi%3BMiura%2C+Daishiro%3BHeflich%2C+Robert+H%3BFerguson%2C+Sherry+A&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2010-03-01&rft.volume=51&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20519 L2 - http://www3.interscience.wiley.com/journal/122539394/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mutagens; Pediatrics; Monoclonal antibodies; Adolescence; Point mutation; Genotoxicity; Erythrocytes; Animal models; Methylphenidate; Mutant frequency; Cancer; Mutagenesis; Flow cytometry; Clastogenicity; Ethyl nitrosourea; Manganese; Sex; Rats; Sensitivity; Mutation; Adolescents; Mutants; Japan, Honshu, Kanagawa Prefect., Miura Peninsula, Miura DO - http://dx.doi.org/10.1002/em.20519 ER - TY - JOUR T1 - K-Ras mutant fraction in A/J mouse lung increases as a function of benzo[a]pyrene dose AN - 745641027; 13159377 AB - K-Ras mutant fraction (MF) was measured to examine the default assumption of low-dose linearity in the benzo[a]pyrene (B[a]P) mutational response. Groups of 10 male A/J mice (7- to 9-weeks old) received a single i.p. injection of ,0.0,0.5, 5, or 50 mg/kg B[a]P and were sacrificed 28 days after treatment. K-Ras codon 12 TGT and GAT MFs in lung DNAs were measured using Allele-specific Competitive Blocker-PCR (ACB-PCR). The K-Ras codon 12 TGT geometric mean MF was 3.88 X 10-4 in controls, indicating an average of 1 mutation in every 1,288 lung cells. The K-Ras codon 12 TGT geometric mean MFs were as follows: 3.56 X 10-4; 6.19 X 10-4; 2.02 X 10-3, and 3.50 X 10-3 for the 0.0,0.5, 5, and 50 mg/kg B[a]P treatment groups, respectively. The 5 and 50 mg/kg dose groups had TGT MFs significantly higher than did controls. Although 10-5 is considered as the limit of accurate ACB-PCR quantitation, K-Ras codon 12 GAT geometric mean MFs were as follows: 8.38 X 10-7, 1.47 X 10-6, 2.19 X 10-6, 5.71 X 10-6, and 8.99 X 10-6 for the ,0.0,0.5, 5, and 50 mg/kg B[a]P treatment groups, respectively. The K-Ras TGT and GAT MFs increased in a B[a]P-dose-dependent manner, with response approximately linear over the 0.05 to 5 mg/kg dose range. K-Ras MF increased with B[a]P adduct burden measured for identical doses in a separate study. Thus, ACB-PCR may be useful in characterizing the shape of a dose-response curve at low doses and establishing relationships between DNA adducts and tumor-associated mutations. Environ. Mol. Mutagen. 2010. Published 2009 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Meng, Fanxue AU - Knapp, Geremy W AU - Green, Terry AU - Ross, Jeffrey A AU - Parsons, Barbara L AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, fanxue.meng@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 146 EP - 155 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 51 IS - 2 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Mutagens KW - DNA adducts KW - Mice KW - Mutants KW - Mutagenesis KW - K-Ras protein KW - Lung KW - Dose-response effects KW - DNA KW - Codons KW - Benzo(a)pyrene KW - Mutation KW - Quantitation KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745641027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=K-Ras+mutant+fraction+in+A%2FJ+mouse+lung+increases+as+a+function+of+benzo%5Ba%5Dpyrene+dose&rft.au=Meng%2C+Fanxue%3BKnapp%2C+Geremy+W%3BGreen%2C+Terry%3BRoss%2C+Jeffrey+A%3BParsons%2C+Barbara+L&rft.aulast=Meng&rft.aufirst=Fanxue&rft.date=2010-03-01&rft.volume=51&rft.issue=2&rft.spage=146&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20513 L2 - http://www3.interscience.wiley.com/journal/122539395/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - DNA adducts; Mutagens; K-Ras protein; Lung; Codons; Benzo(a)pyrene; Quantitation; Mutation; Mutagenesis; Dose-response effects; DNA; Mice; Mutants DO - http://dx.doi.org/10.1002/em.20513 ER - TY - JOUR T1 - Waterborne gastroenteritis outbreak at a scouting camp caused by two norovirus genogroups: GI and GII AN - 745633430; 13015995 AB - A cross-border gastroenteritis outbreak at a scouting camp was associated with drinking water from a farmer's well. A retrospective cohort study was performed to identify size and source of the outbreak, as well as other characteristics. Epidemiological investigation included standardized questionnaires about sex, age, risk exposures, illness and family members. Stool and water (100mL) samples were analyzed for bacteria, viruses and parasites. Questionnaires were returned by 84 scouts (response rate 82%), mean age of 13 years. The primary attack rate was 85% (diarrhoea and/or vomiting). Drinking water was the strongest independent risk factor showing a dose-response effect with 50%, 75%, 75%, 93% and 96% case prevalence for 0, 1, 2-3, 4-5 and >5 glasses consumed, respectively. Norovirus (GI.2 Southampton and GII.7 Leeds) was detected in 51 stool specimens (75%) from ill scouts. Water analysis showed fecal contamination, but no norovirus. The secondary attack rate was 20%. This remarkable outbreak was caused by a point-source infection with two genogroups of noroviruses most likely transmitted by drinking water from a well. Finding a dose-response relationship was striking. Specific measures to reduce the risk of waterborne diseases, outbreak investigation and a good international public health network are important. JF - Journal of Clinical Virology AU - ter Waarbeek, HenriA'tte LG AU - Dukers-Muijrers, Nicole HTM AU - Vennema, Harry AU - Hoebe, Christian JPA AD - Department of Infectious Diseases, Public Health Service South Limburg, PO Box 2022, 6160 HA Geleen, The Netherlands Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 268 EP - 272 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 47 IS - 3 SN - 1386-6532, 1386-6532 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Age KW - Norovirus KW - Drinking water KW - A 01450:Environmental Pollution & Waste Treatment KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745633430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Waterborne+gastroenteritis+outbreak+at+a+scouting+camp+caused+by+two+norovirus+genogroups%3A+GI+and+GII&rft.au=ter+Waarbeek%2C+HenriA%27tte+LG%3BDukers-Muijrers%2C+Nicole+HTM%3BVennema%2C+Harry%3BHoebe%2C+Christian+JPA&rft.aulast=ter+Waarbeek&rft.aufirst=HenriA%27tte&rft.date=2010-03-01&rft.volume=47&rft.issue=3&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2009.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drinking water; Norovirus DO - http://dx.doi.org/10.1016/j.jcv.2009.12.002 ER - TY - JOUR T1 - Drug interactions evaluation: An integrated part of risk assessment of therapeutics AN - 745632710; 13016155 AB - Pharmacokinetic drug interactions can lead to serious adverse events or decreased drug efficacy. The evaluation of a new molecular entity's (NME's) drug-drug interaction potential is an integral part of risk assessment during drug development and regulatory review. Alteration of activities of enzymes or transporters involved in the absorption, distribution, metabolism, or excretion of a new molecular entity by concomitant drugs may alter drug exposure, which can impact response (safety or efficacy). The recent Food and Drug Administration (FDA) draft drug interaction guidance (http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryIn f ormation/Guidances/ucm072101.pdf) highlights the methodologies and criteria that may be used to guide drug interaction evaluation by industry and regulatory agencies and to construct informative labeling for health practitioner and patients. In addition, the Food and Drug Administration established a "Drug Development and Drug Interactions" website to provide up-to-date information regarding evaluation of drug interactions (http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentRe s ources/DrugInteractionsLabeling/ucm080499.htm). This review summarizes key elements in the FDA drug interaction guidance and new scientific developments that can guide the evaluation of drug-drug interactions during the drug development process. JF - Toxicology and Applied Pharmacology AU - Zhang, Lei AU - Reynolds, Kellie S AU - Zhao, Ping AU - Huang, Shiew-Mei AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Building 51, Room 3188, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA, shiewmei.huang@fda.hhs.gov Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 134 EP - 145 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 243 IS - 2 SN - 0041-008X, 0041-008X KW - Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts; Risk Abstracts KW - Absorption KW - Drug interaction KW - Drugs KW - X 24310:Pharmaceuticals KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745632710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Drug+interactions+evaluation%3A+An+integrated+part+of+risk+assessment+of+therapeutics&rft.au=Zhang%2C+Lei%3BReynolds%2C+Kellie+S%3BZhao%2C+Ping%3BHuang%2C+Shiew-Mei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2010-03-01&rft.volume=243&rft.issue=2&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.12.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Drug interaction; Drugs DO - http://dx.doi.org/10.1016/j.taap.2009.12.016 ER - TY - JOUR T1 - Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity AN - 745632692; 13016153 AB - Hepatotoxicity and nephrotoxicity are two major reasons that drugs are withdrawn post-market, and hence it is of major concern to both the FDA and pharmaceutical companies. The number of cases of serious adverse effects (SAEs) in marketed drugs has climbed faster than the number of total drug prescriptions issued. In some cases, preclinical animal studies fail to identify the potential toxicity of a new chemical entity (NCE) under development. The current clinical chemistry biomarkers of liver and kidney injury are inadequate in terms of sensitivity and/or specificity, prompting the need to discover new translational specific biomarkers of organ injury. Metabolomics along with genomics and proteomics technologies have the capability of providing translational diagnostic and prognostic biomarkers specific for early stages of liver and kidney injury. Metabolomics has several advantages over the other omics platforms such as ease of sample preparation, data acquisition and use of biofluids collected through minimally invasive procedures in preclinical and clinical studies. The metabolomics platform is reviewed with particular emphasis on applications involving drug-induced hepatotoxicity and nephrotoxicity. Analytical platforms for metabolomics, chemometrics for mining metabolomics data and the applications of the metabolomics technologies are covered in detail with emphasis on recent work in the field. JF - Toxicology and Applied Pharmacology AU - Beger, Richard D AU - Sun, Jinchun AU - Schnackenberg, Laura K AD - Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079-9502, USA, richard.beger@fda.hhs.gov Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 154 EP - 166 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 243 IS - 2 SN - 0041-008X, 0041-008X KW - Health & Safety Science Abstracts; Environment Abstracts; Toxicology Abstracts KW - Bioindicators KW - metabolomics KW - X 24310:Pharmaceuticals KW - H 4000:Food and Drugs KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745632692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Metabolomics+approaches+for+discovering+biomarkers+of+drug-induced+hepatotoxicity+and+nephrotoxicity&rft.au=Beger%2C+Richard+D%3BSun%2C+Jinchun%3BSchnackenberg%2C+Laura+K&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2010-03-01&rft.volume=243&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2009.11.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - metabolomics; Bioindicators DO - http://dx.doi.org/10.1016/j.taap.2009.11.019 ER - TY - JOUR T1 - Prediction of porosity and permeability of caved zone in longwall gobs AN - 742909685; 2010-047866 AB - The porosity and permeability of the caved zone (gob) in a longwall operation impact many ventilation and methane control related issues, such as air leakage into the gob, the onset of spontaneous combustion, methane and air flow patterns in the gob, and the interaction of gob gas ventholes with the mining environment. Despite its importance, the gob is typically inaccessible for performing direct measurements of porosity and permeability. Thus, there has always been debate on the likely values of porosity and permeability of the caved zone and how these values can be predicted. This study demonstrates a predictive approach that combines fractal scaling in porous medium with principles of fluid flow. The approach allows the calculation of porosity and permeability from the size distribution of broken rock material in the gob, which can be determined from image analyzes of gob material using the theories on a completely fragmented porous medium. The virtual fragmented fractal porous medium so generated is exposed to various uniaxial stresses to simulate gob compaction and porosity and permeability changes during this process. The results suggest that the gob porosity and permeability values can be predicted by this approach and the presented models are capable to produce values close to values documented by other researchers. Copyright 2010 Springer Science+Business Media B.V. and 2009 US Government JF - Transport in Porous Media AU - Karacan, C Ozgen Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 413 EP - 439 PB - Springer, Dordrecht VL - 82 IS - 2 SN - 0169-3913, 0169-3913 KW - fractured materials KW - mining KW - underground mining KW - aliphatic hydrocarbons KW - fluid dynamics KW - uniaxial tests KW - rock mechanics KW - ventilation KW - granular materials KW - mining geology KW - aeration KW - fractals KW - methane KW - stress KW - tortuosity KW - porous materials KW - capillarity KW - alkanes KW - deformation KW - porosity KW - organic compounds KW - longwall mining KW - hydrocarbons KW - air KW - permeability KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742909685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transport+in+Porous+Media&rft.atitle=Prediction+of+porosity+and+permeability+of+caved+zone+in+longwall+gobs&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2010-03-01&rft.volume=82&rft.issue=2&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Transport+in+Porous+Media&rft.issn=01693913&rft_id=info:doi/10.1007%2Fs11242-009-9437-7 L2 - http://springerlink.metapress.com/(l4tqdq55jga2hgb0achos1qm)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100342,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by Springer Verlag, Berlin, Federal Republic of Germany N1 - Date revised - 2010-01-01 N1 - Number of references - 38 N1 - Document feature - illus. incl. 9 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aeration; air; aliphatic hydrocarbons; alkanes; capillarity; deformation; fluid dynamics; fractals; fractured materials; granular materials; hydrocarbons; longwall mining; methane; mining; mining geology; organic compounds; permeability; porosity; porous materials; rock mechanics; stress; tortuosity; underground mining; uniaxial tests; ventilation DO - http://dx.doi.org/10.1007/s11242-009-9437-7 ER - TY - JOUR T1 - Advancing Efforts to Improve Children's Mental Health in America: A Commentary AN - 742724083; 201015153 AB - Abstract not available. JF - Administration and Policy in Mental Health AND Mental Health Services Research AU - Blau, Gary M AU - Huang, Larke N AU - Mallery, Coretta J AD - Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 140 EP - 144 PB - Springer, Dordrecht The Netherlands VL - 37 IS - 1-2 SN - 0894-587X, 0894-587X KW - Paediatrics KW - Quality of care KW - Mental health services KW - Service provision KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742724083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.atitle=Advancing+Efforts+to+Improve+Children%27s+Mental+Health+in+America%3A+A+Commentary&rft.au=Blau%2C+Gary+M%3BHuang%2C+Larke+N%3BMallery%2C+Coretta+J&rft.aulast=Blau&rft.aufirst=Gary&rft.date=2010-03-01&rft.volume=37&rft.issue=1-2&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Administration+and+Policy+in+Mental+Health+AND+Mental+Health+Services+Research&rft.issn=0894587X&rft_id=info:doi/10.1007%2Fs10488-010-0290-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - APMHEM N1 - SubjectsTermNotLitGenreText - Mental health services; Paediatrics; Quality of care; Service provision DO - http://dx.doi.org/10.1007/s10488-010-0290-3 ER - TY - JOUR T1 - Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice. AN - 734277717; 19642212 AB - Children are generally more sensitive to toxicants than adults, including an increased sensitivity to genotoxic carcinogens. We previously demonstrated that neonatal mice are also more sensitive to the mutagenic effects of the direct alkylating agents N-ethyl-N-nitrosoamine and the arylamine 4-aminobiphenyl than adult mice. In this study, we have evaluated the effect of age on the mutagenicity of the fungal toxin and liver carcinogen aflatoxin B(1) (AFB(1)). Neonatal Big Blue transgenic mice were treated with 6 mg/kg AFB(1), a treatment that produces liver tumors, while adult mice were treated with 6 and 60 mg/kg AFB(1), treatments that do not result in tumors. The cII liver mutant frequency (MF) in mice treated with AFB(1) as neonates was 22-fold higher than in control neonatal mice, whereas the treatment of adult mice with either dose of AFB(1) did not significantly increase the liver MF over the controls. In AFB(1)-treated neonatal mice, the frequency of G:C --> T:A transversion, a major type of mutation induced by AFB(1), was about 82-fold higher than for the control and 31-fold higher than for adult mice treated with 60 mg/kg AFB(1). Our mutagenicity findings parallel the relative carcinogenicity of AFB(1) in neonatal and adult mice, and are consistent with previous observations of the lower level of hepatic glutathione S-transferase and higher level of hepatic AFB(1)-DNA adduction in neonatal mice compared to adult mice. Published 2009 by Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Chen, Tao AU - Heflich, Robert H AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. tao.chen@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 156 EP - 163 VL - 51 IS - 2 KW - Poisons KW - 0 KW - Transcription Factors KW - Viral Proteins KW - cII protein, bacteriophage lambda KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Viral Proteins -- genetics KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - Humans KW - Genome -- drug effects KW - Point Mutation KW - Liver Neoplasms -- chemically induced KW - Genes, Reporter KW - Mice KW - Transcription Factors -- genetics KW - Male KW - Liver Neoplasms -- genetics KW - Poisons -- toxicity KW - Liver -- drug effects KW - DNA Damage KW - Poisons -- administration & dosage KW - Aging KW - Aflatoxin B1 -- administration & dosage KW - Aflatoxin B1 -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734277717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Differential+mutagenicity+of+aflatoxin+B1+in+the+liver+of+neonatal+and+adult+mice.&rft.au=Chen%2C+Tao%3BHeflich%2C+Robert+H%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Chen&rft.aufirst=Tao&rft.date=2010-03-01&rft.volume=51&rft.issue=2&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.20518 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-03 N1 - Date created - 2010-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/em.20518 ER - TY - JOUR T1 - The limits of regulatory toxicology. AN - 733706320; 20035778 AB - The Acceptable Daily Intake (ADI) has been used by regulatory and public health organizations (e.g., the U.S. Food and Drug and Administration, and the World Health Organization) for chemicals for more than 50 years. The ADI concept was also initially employed at the U.S. Environmental Protection Agency at its inception in 1971, although with the adoption of newer terminology, it later became known as the Reference Dose (RfD). It is clear from the literature that both were first devised as instruments of regulatory policy. In the intervening years, it has become common to use language that implies that these standards are statements of scientific fact. Similarly, some of the discretionary or default values that are used to derive regulatory standards are represented as scientific assumptions when in fact they also represent regulatory policy. This confusion impedes both the best use of the available science and informed public participation in policy making. In addition, the misconception of the ADI or the RfD as statements of scientific fact may impede the consideration of alternative means to reduce exposure to chemicals that may be harmful, including regulatory measures that do not involve prescribing a regulatory concentration limit. JF - Toxicology and applied pharmacology AU - Carrington, Clark D AU - Bolger, P Michael AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 191 EP - 197 VL - 243 IS - 2 KW - Lead KW - 2P299V784P KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - United States KW - Lead -- adverse effects KW - Animals KW - United States Environmental Protection Agency KW - Mercury -- adverse effects KW - Humans KW - Food Analysis KW - Reference Standards KW - Mercury -- analysis KW - Lead -- analysis KW - Toxicology -- legislation & jurisprudence KW - Legislation, Drug -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733706320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=The+limits+of+regulatory+toxicology.&rft.au=Carrington%2C+Clark+D%3BBolger%2C+P+Michael&rft.aulast=Carrington&rft.aufirst=Clark&rft.date=2010-03-01&rft.volume=243&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2009.12.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-15 N1 - Date created - 2010-02-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.taap.2009.12.017 ER - TY - JOUR T1 - Age-related differences in susceptibility to cisplatin-induced renal toxicity. AN - 733684623; 19839026 AB - Limited experimental models exist to assess drug toxicity in pediatric populations. We recently reported how a multi-age rat model could be used for pre-clinical studies of comparative drug toxicity in pediatric populations. The objective of this study was to expand the utility of this animal model, which previously demonstrated an age-dependent sensitivity to the classic nephrotoxic compound, gentamicin, to another nephrotoxicant, namely cisplatin (Cis). Sprague-Dawley rats (10, 25, 40 and 80 days old) were injected with a single dose of Cis (0, 1, 3 or 6 mg kg(-1) i.p.). Urine samples were collected prior and up to 72 h after treatment in animals that were >or= 25 days old. Several serum, urinary and 'omic' injury biomarkers as well as renal histopathology lesions were evaluated. Statistically significant changes were noted with different injury biomarkers in different age groups. The order of age-related Cis-induced nephrotoxicity was different than our previous study with gentamicin: 80 > 40 > 10 > 25 day-old vs 10 >or= 80 > 40 > 25-day-old rats, respectively. The increased levels of kidney injury molecule-1 (Kim-1: urinary protein/tissue mRNA) provided evidence of early Cis-induced nephrotoxicity in the most sensitive age group (80 days old). Levels of Kim-1 tissue mRNA and urinary protein were significantly correlated to each other and to the severity of renal histopathology lesions. These data indicate that the multi-age rat model can be used to demonstrate different age-related sensitivities to renal injury using mechanistically distinct nephrotoxicants, which is reflected in measurements of a variety of metabolite, gene transcript and protein biomarkers. JF - Journal of applied toxicology : JAT AU - Espandiari, P AU - Rosenzweig, B AU - Zhang, J AU - Zhou, Y AU - Schnackenberg, L AU - Vaidya, V S AU - Goering, P L AU - Brown, R P AU - Bonventre, J V AU - Mahjoob, K AU - Holland, R D AU - Beger, R D AU - Thompson, K AU - Hanig, J AU - Sadrieh, N AD - Center for Drug Evaluation and Research, FDA, Silver Spring, MD 20993, USA. parvaneh.espandiari@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 172 EP - 182 VL - 30 IS - 2 KW - Biomarkers KW - 0 KW - Gentamicins KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Sensitivity and Specificity KW - Models, Animal KW - Animals KW - Age Factors KW - Pediatrics KW - Humans KW - Biomarkers -- urine KW - Child KW - Disease Susceptibility -- metabolism KW - Rats KW - Gentamicins -- toxicity KW - Rats, Sprague-Dawley KW - Biomarkers -- metabolism KW - Disease Susceptibility -- pathology KW - Aging -- physiology KW - Kidney Diseases -- pathology KW - Kidney -- metabolism KW - Kidney -- pathology KW - Cisplatin -- toxicity KW - Kidney Diseases -- urine KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733684623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Age-related+differences+in+susceptibility+to+cisplatin-induced+renal+toxicity.&rft.au=Espandiari%2C+P%3BRosenzweig%2C+B%3BZhang%2C+J%3BZhou%2C+Y%3BSchnackenberg%2C+L%3BVaidya%2C+V+S%3BGoering%2C+P+L%3BBrown%2C+R+P%3BBonventre%2C+J+V%3BMahjoob%2C+K%3BHolland%2C+R+D%3BBeger%2C+R+D%3BThompson%2C+K%3BHanig%2C+J%3BSadrieh%2C+N&rft.aulast=Espandiari&rft.aufirst=P&rft.date=2010-03-01&rft.volume=30&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.1484 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-25 N1 - Date created - 2010-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gut. 1991 Nov;32(11):1321-3 [1752463] Exp Pathol. 1990;38(4):231-9 [2387365] Semin Nephrol. 1997 Jan;17(1):54-66 [9000550] J Biol Chem. 1998 Feb 13;273(7):4135-42 [9461608] JAMA. 1998 Apr 15;279(15):1200-5 [9555760] BMJ. 1998 Apr 25;316(7140):1295-8 [9554902] J Nucl Med. 1998 May;39(5):865-9 [9591590] Food Addit Contam. 1998;15 Suppl:45-51 [9602911] Food Addit Contam. 1998;15 Suppl:53-4 [9602912] Med J Aust. 1998 Oct 5;169(7):356-9 [9803246] Kidney Int. 1998 Dec;54(6):1817-31 [9853246] J Clin Pharm Ther. 1999 Feb;24(1):73-80 [10319910] J Am Soc Nephrol. 2005 Apr;16(4):1126-34 [15744000] J Toxicol Environ Health B Crit Rev. 2004 Nov-Dec;7(6):417-35 [15586877] Epilepsia. 1999 Jul;40(7):985-91 [10403224] Contrib Nephrol. 2005;148:107-21 [15912030] Br J Clin Pharmacol. 2005 Jun;59(6):670-3 [15948930] Pediatr Hematol Oncol. 2005 Jul-Aug;22(5):441-5 [16020136] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] OMICS. 2006 Spring;10(1):1-14 [16584314] Am J Physiol Renal Physiol. 2006 Aug;291(2):F456-64 [16467126] Expert Opin Drug Metab Toxicol. 2006 Oct;2(5):697-713 [17014390] Toxicol Sci. 2007 Oct;99(2):637-48 [17636248] Toxicol Sci. 2008 Jan;101(1):159-70 [17934191] J Appl Toxicol. 2008 Jul;28(5):628-37 [17994530] Food Chem Toxicol. 2008 Nov;46(11):3355-9 [18790000] Environ Health Perspect. 2000 Mar;108 Suppl 1:13-21 [10698720] Br J Clin Pharmacol. 2001 Jul;52(1):77-83 [11453893] Epilepsia. 2002;43 Suppl 3:53-9 [12060006] Kidney Int. 2002 Jul;62(1):237-44 [12081583] Am J Physiol Renal Physiol. 2002 Dec;283(6):F1326-36 [12388382] Cancer Chemother Pharmacol. 2003 Jul;52(1):13-8 [12719883] Birth Defects Res B Dev Reprod Toxicol. 2003 Apr;68(2):111-20 [12866702] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Environ Health Perspect. 2004 Mar;112(4):488-94 [15033599] Eur J Pediatr. 1980;133(1):25-9 [7353568] Toxicology. 1984 Sep 28;32(4):343-53 [6541377] Eur J Biochem. 1985 Sep 2;151(2):345-50 [2411555] Pediatr Res. 1985 Nov;19(11):1191-6 [4069829] Lancet. 1987 Jan 3;1(8523):47-8 [2879132] Neurology. 1989 Feb;39(2 Pt 1):201-7 [2492646] Biomed Biochim Acta. 1988;47(8):791-7 [3240309] Hum Exp Toxicol. 1996 Jan;15(1):51-55 [8845210] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/jat.1484 ER - TY - JOUR T1 - Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. AN - 733674538; 20008439 AB - Breast cancer, the most common malignancy in women, emerges through a multistep process, encompassing the progressive sequential evolution of morphologically distinct stages from a normal cell to hyperplasia (with and without atypia), carcinoma in situ, invasive carcinoma and metastasis. The success of treatment of breast cancer could be greatly improved by the detection at early stages of cancer. In the present study, we investigated the underlying molecular mechanisms involved in breast carcinogenesis in Augustus and Copenhagen-Irish female rats, a cross between the ACI strains, induced by continuous exposure to 17beta-estradiol. The results of our study demonstrate that early stages of estrogen-induced breast carcinogenesis are characterized by altered global DNA methylation, aberrant expression of proteins responsible for the proper maintenance of DNA methylation pattern and epigenetic silencing of the critical Rassf1a (Ras-association domain family 1, isoform A) tumor suppressor gene. Interestingly, transcriptional repression of the Rassf1a gene in mammary glands during early stages of breast carcinogenesis was associated with an increase in trimethylation of histones H3 lysine 9 and H3 lysine 27 and de novo CpG island methylation and at the Rassf1a promoter and first exon. In conclusion, we demonstrate that epigenetic alterations precede formation of preneoplastic lesions indicating the significance of epigenetic events in induction of oncogenic pathways in early stages of carcinogenesis. JF - Carcinogenesis AU - Starlard-Davenport, Athena AU - Tryndyak, Volodymyr P AU - James, Smitha R AU - Karpf, Adam R AU - Latendresse, John R AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 376 EP - 381 VL - 31 IS - 3 KW - Histones KW - 0 KW - Neoplasm Proteins KW - Tumor Suppressor Proteins KW - Estradiol KW - 4TI98Z838E KW - histone methyltransferase KW - EC 2.1.1.- KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - Index Medicus KW - Animals KW - Mammary Glands, Animal -- drug effects KW - Random Allocation KW - Tumor Suppressor Proteins -- genetics KW - Precancerous Conditions -- metabolism KW - Rats, Inbred ACI KW - Histone-Lysine N-Methyltransferase -- metabolism KW - Tumor Suppressor Proteins -- biosynthesis KW - Rats KW - Exons -- genetics KW - Precancerous Conditions -- genetics KW - Hyperplasia KW - DNA Methylation KW - Mammary Glands, Animal -- metabolism KW - CpG Islands KW - Histones -- metabolism KW - Mammary Glands, Animal -- pathology KW - Promoter Regions, Genetic -- genetics KW - Neoplasm Proteins -- metabolism KW - Female KW - Gene Expression Regulation, Neoplastic KW - Mammary Neoplasms, Experimental -- chemically induced KW - Genes, Tumor Suppressor KW - Gene Silencing KW - Estradiol -- toxicity KW - Mammary Neoplasms, Experimental -- genetics KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733674538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mechanisms+of+epigenetic+silencing+of+the+Rassf1a+gene+during+estrogen-induced+breast+carcinogenesis+in+ACI+rats.&rft.au=Starlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr+P%3BJames%2C+Smitha+R%3BKarpf%2C+Adam+R%3BLatendresse%2C+John+R%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Starlard-Davenport&rft.aufirst=Athena&rft.date=2010-03-01&rft.volume=31&rft.issue=3&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp304 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-14 N1 - Date created - 2010-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Sci. 2007 Sep;98(9):1318-22 [17640295] J Natl Cancer Inst. 2007 Aug 1;99(15):1152-61 [17652280] J Cell Sci. 2007 Sep 15;120(Pt 18):3163-72 [17878233] J Clin Invest. 2007 Nov;117(11):3155-63 [17975657] Mol Cancer. 2008;7:15 [18221536] CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 [18287387] N Engl J Med. 2008 Mar 13;358(11):1148-59 [18337604] Nat Genet. 2008 Jun;40(6):741-50 [18488029] Cell Cycle. 2008 Oct;7(20):3202-10 [18843197] J Mol Med (Berl). 2008 Dec;86(12):1315-28 [18716754] Curr Biol. 2008 Dec 9;18(23):1889-95 [19062280] Epigenetics. 2008 Nov;3(6):315-7 [19098450] Int J Dev Biol. 2009;53(2-3):335-54 [19412890] Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7022-7 [19369208] Clin Biochem. 2009 Jul;42(10-11):970-5 [19374895] CA Cancer J Clin. 2009 Jul-Aug;59(4):225-49 [19474385] Hum Mol Genet. 2009 Aug 15;18(16):3098-109 [19477956] Biochim Biophys Acta. 2009 Dec;1796(2):114-28 [19344752] Cell. 2000 Jan 7;100(1):57-70 [10647931] Cancer Res. 2001 Apr 1;61(7):3105-9 [11306494] Mol Cell Biol. 2002 Jan;22(2):480-91 [11756544] Am J Pathol. 2002 Feb;160(2):605-12 [11839581] Cancer Cell. 2002 May;1(4):299-305 [12086841] Oncogene. 2002 Aug 12;21(35):5462-82 [12154408] Biochim Biophys Acta. 2002 Oct 2;1603(1):1-9 [12242106] Curr Biol. 2002 Dec 23;12(24):2159-66 [12498693] Adv Exp Med Biol. 2003;532:195-207 [12908558] Cancer Res. 2003 Oct 1;63(19):6178-86 [14559801] Nat Med. 2004 Aug;10(8):789-99 [15286780] Anal Chem. 2005 Jan 15;77(2):504-10 [15649046] J Pathol. 2005 Jan;205(2):248-54 [15641021] Cancer Sci. 2005 Apr;96(4):206-11 [15819717] N Engl J Med. 2006 Jan 19;354(3):270-82 [16421368] Oncol Rep. 2006 May;15(5):1241-8 [16596193] J Biol Chem. 2006 Aug 4;281(31):22062-72 [16735507] Carcinogenesis. 2006 Aug;27(8):1713-20 [16632870] Nat Genet. 2007 Feb;39(2):232-6 [17200670] Cell. 2007 Feb 23;128(4):683-92 [17320506] Dis Markers. 2007;23(1-2):73-87 [17325427] Mutat Res. 2007 May 1;618(1-2):163-74 [17306846] Int J Oncol. 2007 Jul;31(1):113-20 [17549411] Breast Cancer Res. 2007;9(3):R28 [17477859] Biochim Biophys Acta. 2007 Sep;1776(1):58-85 [17692468] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp304 ER - TY - JOUR T1 - Nanoparticle emission assessment technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials--part A. AN - 733622369; 20017054 AB - There are currently no exposure limits specific to engineered nanomaterial nor any national or international consensus standards on measurement techniques for nanomaterials in the workplace. However, facilities engaged in the production and use of engineered nanomaterials have expressed an interest in learning whether the potential for worker exposure exists. To assist with answering this question, the National Institute for Occupational Safety and Health established a nanotechnology field research team whose primary goal was to visit facilities and evaluate the potential for release of nanomaterials and worker exposure. The team identified numerous techniques to measure airborne nanomaterials with respect to particle size, mass, surface area, number concentration, and composition. However, some of these techniques lack specificity and field portability and are difficult to use and expensive when applied to routine exposure assessment. This article describes the nanoparticle emission assessment technique (NEAT) that uses a combination of measurement techniques and instruments to assess potential inhalation exposures in facilities that handle or produce engineered nanomaterials. The NEAT utilizes portable direct-reading instrumentation supplemented by a pair of filter-based air samples (source-specific and personal breathing zone). The use of the filter-based samples are crucial for identification purposes because particle counters are generally insensitive to particle source or composition and make it difficult to differentiate between incidental and process-related nanomaterials using number concentration alone. Results from using the NEAT at 12 facilities are presented in the companion article (Part B) in this issue. JF - Journal of occupational and environmental hygiene AU - Methner, M AU - Hodson, L AU - Geraci, C AD - National Institute for Occupational Safety and Health, Nanotechnology Research Center, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. MMethner@cdc.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 127 EP - 132 VL - 7 IS - 3 KW - Air Pollutants KW - 0 KW - Index Medicus KW - Workplace KW - Inhalation Exposure -- analysis KW - Nanoparticles -- analysis KW - Air Pollutants -- analysis KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Air Pollutants -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733622369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Nanoparticle+emission+assessment+technique+%28NEAT%29+for+the+identification+and+measurement+of+potential+inhalation+exposure+to+engineered+nanomaterials--part+A.&rft.au=Methner%2C+M%3BHodson%2C+L%3BGeraci%2C+C&rft.aulast=Methner&rft.aufirst=M&rft.date=2010-03-01&rft.volume=7&rft.issue=3&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459620903476355 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-02 N1 - Date created - 2009-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1080/15459620903476355 ER - TY - JOUR T1 - The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys. AN - 733334954; 19737611 AB - Methylphenidate (MPH) is an amphetamine derivative widely prescribed for the treatment of attention deficit-hyperactivity disorder. Recent concern over its genotoxic potential in children [11] spurred a study on the effects of chronic MPH treatment in a nonhuman primate population and the studies reported here were conducted in conjunction with that study in the same animals. Here, the focus was on the ability of juvenile rhesus monkeys to learn how to perform a battery of operant behavioral tasks while being treated chronically with MPH. Performance of the National Center for Toxicological Research (NCTR) Operant Test Battery (OTB) was used to quantify the learning of tasks thought to model specific aspects of cognitive function including learning, motivation, color and position discrimination, and short-term memory. The OTB tasks designed to assess these specific behaviors included Incremental Repeated Acquisition (IRA), Progressive Ratio (PR), Conditioned Position Responding (CPR), and Delayed Matching-to-Sample (DMTS), respectively. Juvenile males (n=10/group) pressed levers and press-plates for banana-flavored food pellets. Subjects were treated orally, twice a day, five days per week (M-F) for 66 weeks with escalating doses (0.15 mg/kg initially, increased to 2.5 mg/kg for the low dose group and to 12.5 mg/kg for the high dose group) and tested in OTB tasks 30 to 60 min after the morning dose. The findings indicate that MPH at doses up to 2.5 mg/kg twice per day were well tolerated (performance was no different than controls) but at doses of 12.5 mg/kg twice per day there was a significant decrement in OTB performance, characterized by decreases in both percent task completed and response rates for all tasks. These effects of MPH seem primarily due to decreases in motivation to perform for food, which is not surprising given the well known appetite suppressing effects of amphetamine-like stimulants. Thus, the current data do not strongly suggest cognitive impairments following chronic MPH administration. Copyright (c) 2009 Elsevier Inc. All rights reserved. JF - Neurotoxicology and teratology AU - Rodriguez, J S AU - Morris, S M AU - Hotchkiss, C E AU - Doerge, D R AU - Allen, R R AU - Mattison, D R AU - Paule, M G AD - Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States. rodriguezj13@uthscsa.edu PY - 2010 SP - 142 EP - 151 VL - 32 IS - 2 KW - Appetite Depressants KW - 0 KW - Central Nervous System Stimulants KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Age Factors KW - Drug Administration Schedule KW - Conditioning, Operant -- physiology KW - Dose-Response Relationship, Drug KW - Disease Models, Animal KW - Appetite -- drug effects KW - Appetite Depressants -- pharmacology KW - Aging -- physiology KW - Behavior, Animal -- drug effects KW - Time KW - Motivation -- drug effects KW - Behavior, Animal -- physiology KW - Macaca mulatta KW - Neuropsychological Tests KW - Motivation -- physiology KW - Male KW - Brain -- physiopathology KW - Central Nervous System Stimulants -- toxicity KW - Brain -- drug effects KW - Cognition Disorders -- chemically induced KW - Methylphenidate -- toxicity KW - Cognition Disorders -- physiopathology KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733334954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=The+effects+of+chronic+methylphenidate+administration+on+operant+test+battery+performance+in+juvenile+rhesus+monkeys.&rft.au=Rodriguez%2C+J+S%3BMorris%2C+S+M%3BHotchkiss%2C+C+E%3BDoerge%2C+D+R%3BAllen%2C+R+R%3BMattison%2C+D+R%3BPaule%2C+M+G&rft.aulast=Rodriguez&rft.aufirst=J&rft.date=2010-03-01&rft.volume=32&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2009.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-15 N1 - Date created - 2010-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Atten Disord. 2002;6 Suppl 1:S31-43 [12685517] Biol Psychiatry. 2003 Dec 15;54(12):1307-9 [14675792] Am J Psychiatry. 2003 Nov;160(11):1909-18 [14594733] Biol Psychiatry. 2003 Dec 15;54(12):1317-29 [14675795] Neurotoxicol Teratol. 2004 May-Jun;26(3):461-76 [15113607] Ann N Y Acad Sci. 2004 Jun;1021:465-9 [15251931] J Am Acad Child Adolesc Psychiatry. 2004 Nov;43(11):1422-9 [15502602] Clin Pediatr (Phila). 1980 Jul;19(7):453-4 [6929749] Pharmacol Biochem Behav. 1984 Mar;20(3):317-21 [6709667] J Pharmacol Exp Ther. 1988 Apr;245(1):178-86 [2834536] Neurotoxicology. 1988 Fall;9(3):367-78 [3143955] Life Sci. 1989;45(6):465-75 [2770412] Pediatrics. 1990 Aug;86(2):184-92 [2196520] Neurotoxicol Teratol. 1996 Mar-Apr;18(2):155-66 [8709927] Pharmacol Biochem Behav. 1997 Dec;58(4):1095-102 [9408219] Cereb Cortex. 1998 Mar;8(2):164-72 [9542895] J Child Adolesc Psychopharmacol. 1998;8(1):13-25 [9639076] Ann N Y Acad Sci. 1998 May 30;844:178-82 [9668675] Neurotoxicol Teratol. 1999 May-Jun;21(3):223-30 [10386825] J Clin Psychiatry. 2005 Feb;66(2):253-9 [15705013] Front Biosci. 2005;10:2240-9 [15970490] Cancer Lett. 2005 Dec 18;230(2):284-91 [16297714] Brain Res Bull. 2006 Feb 15;68(6):393-405 [16459193] J Clin Psychiatry. 2006;67 Suppl 8:7-12 [16961424] Neuropsychopharmacology. 2006 Nov;31(11):2376-83 [16855530] Biol Psychiatry. 2006 Nov 15;60(10):1111-20 [16806100] Brain Res. 2007 May 11;1145:66-80 [17335781] Arch Gen Psychiatry. 2007 Aug;64(8):932-40 [17679638] J Child Neurol. 2007 May;22(5):538-42 [17690058] Neurobiol Learn Mem. 2007 Oct;88(3):312-20 [17544718] Behav Neurosci. 2007 Dec;121(6):1272-9 [18085880] Harv Rev Psychiatry. 2008;16(3):151-66 [18569037] Mutat Res. 2009 Feb 19;673(1):59-66 [19135169] Rapid Commun Mass Spectrom. 2000;14(8):619-23 [10786896] Neurotoxicol Teratol. 2000 Sep-Oct;22(5):683-94 [11106861] Neurotoxicol Teratol. 2001 Jul-Aug;23(4):319-32 [11485835] Neurotoxicol Teratol. 2001 Jul-Aug;23(4):333-47 [11485836] Clin Pediatr (Phila). 2003 Mar;42(2):159-64 [12659390] J Oral Sci. 2003 Jun;45(2):75-83 [12930130] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2009.08.011 ER - TY - JOUR T1 - Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 rats. AN - 733334764; 19846048 AB - Acrylamide (ACR) is a relatively potent neurotoxicant. The ingestion of carbohydrate-containing foods cooked at high temperature exposes humans to low levels of ACR virtually daily. At relatively high levels of exposure (i.e., sub-chronic through chronic levels of exposure of >or=20mg/kg body weight/day), ACR has been shown in both rats and humans to produce a variety of effects on the nervous system. The possibility that chronic dietary exposure to ACR might produce brain toxicity which could impede the development of learning skills is a question of current concern. This research evaluated the effects of ACR on learning task performance in Fischer 344 rats exposed daily beginning prenatally and continuing throughout the lifespan. Dams were gavaged with ACR since implantation [gestation day (GD) 6] with 0, 0.1, 0.3, 1.0 or 5.0mg/kg/day through parturition. Gavaging continued at the same doses to pups through weaning on post-natal day (PND) 22 after which dosing continued via their drinking water. One male and one female per litter (8-9 per treatment group) were tested. Using an incremental repeated acquisition (IRA) task to assess learning ability, ACR-exposed Fischer 344 rats exhibited altered performance by 4 months of age. From approximately 1-8 months of age (through approximately PND 240), over 52 testing sessions, a significant treatment effect was found on percent task completed (PTC), with Tukey's post-hoc test (P<0.05) indicating a significantly lower PTC for the 5.0mg/kg/day group compared to controls. While there was no treatment effect on accuracy (P=0.53), a significant decrease in response rate was seen at 5.0mg/kg/day, suggesting that the noted decrease in PTC was due to a decrease in rate of responding, not to an effect on accuracy of task solution. Previous findings in these same animals performing a progressive ratio task for the assessment of motivation, as well as a range of tests of motoric function, suggest that this decreased response rate could be due to subtle motoric effects, or possibly due to decreases in psychomotor speed, but is most likely due to motivational effects. Copyright (c) 2009 Elsevier Inc. All rights reserved. JF - Neurotoxicology and teratology AU - Garey, Joan AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72211, United States. jgarey@srcinc.com PY - 2010 SP - 220 EP - 225 VL - 32 IS - 2 KW - Neurotoxins KW - 0 KW - Acrylamide KW - 20R035KLCI KW - Index Medicus KW - Administration, Oral KW - Reaction Time -- drug effects KW - Animals KW - Drug Administration Schedule KW - Learning -- physiology KW - Neurotoxicity Syndromes -- physiopathology KW - Disease Models, Animal KW - Learning -- drug effects KW - Food, Formulated -- adverse effects KW - Reaction Time -- physiology KW - Pregnancy KW - Rats KW - Rats, Inbred F344 KW - Psychomotor Performance -- drug effects KW - Motivation -- drug effects KW - Environmental Exposure -- adverse effects KW - Neuropsychological Tests KW - Female KW - Male KW - Learning Disorders -- physiopathology KW - Cognition Disorders -- chemically induced KW - Prenatal Exposure Delayed Effects -- physiopathology KW - Neurotoxins -- toxicity KW - Cognition Disorders -- physiopathology KW - Acrylamide -- toxicity KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733334764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Effects+of+chronic+oral+acrylamide+exposure+on+incremental+repeated+acquisition+%28learning%29+task+performance+in+Fischer+344+rats.&rft.au=Garey%2C+Joan%3BPaule%2C+Merle+G&rft.aulast=Garey&rft.aufirst=Joan&rft.date=2010-03-01&rft.volume=32&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2009.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-15 N1 - Date created - 2010-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.ntt.2009.10.001 ER - TY - JOUR T1 - Gender gap in parents' financing strategy for hospitalization of their children: evidence from India AN - 57357157; 201006017 AB - The missing women dilemma in India has sparked great interest in investigating gender discrimination in the provision of health care in the country. No studies, however, have directly examined discrimination in health-care financing strategies in the case of severe illness of sons versus daughters. In this paper, we hypothesize that households who face tight budget constraints are more likely to spend their meager resources on hospitalization of boys rather than girls. We use the 60th round of the Indian National Sample Survey (2004) and a multinomial logit model to test this hypothesis and to throw some light on this important but overlooked issue. The results reveal that boys are much more likely to be hospitalized than girls. When it comes to financing, the gap in the usage of household income and savings is relatively small, while the gender gap in the probability of hospitalization and usage of more onerous financing strategies is very high. Ceteris paribus, the probability of boys to be hospitalized by financing from borrowing, sale of assets, help from friends, etc. is much higher than that of girls. Moreover, in line with our theoretical framework, the results indicate that the gender gap intensifies as we move from the richest to poorest households. [Copyright John Wiley and Sons, Ltd.] JF - Health Economics AU - Asfaw, Abay AU - Lamanna, Francesca AU - Klasen, Stephan AD - National Institute for Occupational Safety and Health, Center for Disease Control and Prevention, Washington, DC, USA Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 265 EP - 279 PB - John Wiley, Chichester UK VL - 19 IS - 3 SN - 1057-9230, 1057-9230 KW - Hospitalization KW - Financing KW - Households KW - Hospitalized KW - Gender KW - India KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57357157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Gender+gap+in+parents%27+financing+strategy+for+hospitalization+of+their+children%3A+evidence+from+India&rft.au=Asfaw%2C+Abay%3BLamanna%2C+Francesca%3BKlasen%2C+Stephan&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2010-03-01&rft.volume=19&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.1468 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - HEECEZ N1 - SubjectsTermNotLitGenreText - Financing; Gender; Households; Hospitalization; Hospitalized; India DO - http://dx.doi.org/10.1002/hec.1468 ER - TY - JOUR T1 - A Call for ACTTION: Increasing Access to Tobacco-Use Treatment in Our Nation AN - 57339649; 201006425 AB - The Consumer Demand Roundtable defined consumer demand for tobacco-use treatments as the degree to which tobacco users who are motivated or activated to quit know about, expect, seek, advocate for, demand, purchase, access, & use tobacco-cessation products & services that have been proven to increase abstinence. Two critical requirements for consumer demand are that tobacco users know about effective treatments & that they have access to these treatments. Despite tobacco use being the leading preventable cause of death in this country, neither of these critical conditions is met in the U.S., particularly for low-income & blue-collar populations, where smoking rates remain highest. Adapted from the source document. JF - American Journal of Preventive Medicine AU - Corinne G. Husten, AD - Center Tobacco Products, Food Drug Administration, Rockville, MD Corinne.Husten@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 414 EP - 417 PB - Elsevier Science, New York NY VL - 38 IS - SUP3 SN - 0749-3797, 0749-3797 KW - Abstinence KW - Consumer demand KW - Smoking KW - Death KW - Advocacy services KW - Low income people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57339649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=A+Call+for+ACTTION%3A+Increasing+Access+to+Tobacco-Use+Treatment+in+Our+Nation&rft.au=Corinne+G.+Husten%2C&rft.aulast=Corinne+G.+Husten&rft.aufirst=&rft.date=2010-03-01&rft.volume=38&rft.issue=SUP3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2009.12.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Smoking; Consumer demand; Advocacy services; Abstinence; Low income people; Death DO - http://dx.doi.org/10.1016/j.amepre.2009.12.006 ER - TY - JOUR T1 - Analysing consumers' 'activism' in response to rising prices AN - 57322062; 201003800 AB - The purpose of this paper was to compose the profile of active consumers in Greece during a period of rising prices taking into account shifts in their consumption. A survey was conducted from 1 September 2008 to 21 November 2008 to collect the primary data source for the study. Questionnaires were administered to 200 consumers. To our knowledge this was the first attempt to offer insight into the characteristics of the Greek consumer in a period of economic crisis. For this purpose, econometric analysis was employed. Empirical results suggested that high-income groups spend more for food commodities and are less likely to be active consumers. It was concluded that consumers have reduced spending for some basic and semi-luxury products like fruits, meat, alcohol, sweets and coffee, and entertainment activities. The main factor which affected the reaction to price increases, as expected, was the monthly private income. Twenty per cent of the consumers are members of a national consumer movement organization, and support their actions against rising prices. Women, who research the market before purchasing a product, are more likely than men to participate in economic boycotts. By examining the profile of non-active consumers and the reasons for their behaviour, we are able to propose a policy for the activation of the Greek consumer movement, which is necessary for the consumers' resistance to rising prices. Taking into consideration that Greek consumers face increased prices for food commodities and services, a policy framework to activate consumers is among the main prerequisites for maintaining consumers' well being. We suggest that the Greek Consumer Protection Institutes should regain consumers' confidence and focus on the dissemination of information about organized economic boycotts. Adapted from the source document. JF - International Journal of Consumer Studies AU - Barda, Constantia AU - Sardianou, Eleni Y1 - 2010/03// PY - 2010 DA - March 2010 SP - 133 EP - 139 PB - Blackwell Publishing, Malden, MA VL - 34 IS - 2 SN - 1470-6423, 1470-6423 KW - Economic crisis KW - Food KW - Prices KW - Economic boycotts KW - Consumers KW - Dissemination KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57322062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Consumer+Studies&rft.atitle=Analysing+consumers%27+%27activism%27+in+response+to+rising+prices&rft.au=Barda%2C+Constantia%3BSardianou%2C+Eleni&rft.aulast=Barda&rft.aufirst=Constantia&rft.date=2010-03-01&rft.volume=34&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Consumer+Studies&rft.issn=14706423&rft_id=info:doi/10.1111%2Fj.1470-6431.2009.00832.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Consumers; Prices; Food; Economic boycotts; Economic crisis; Dissemination DO - http://dx.doi.org/10.1111/j.1470-6431.2009.00832.x ER - TY - JOUR T1 - The Ferrichrome Uptake Pathway in Pseudomonas aeruginosa Involves an Iron Release Mechanism with Acylation of the Siderophore and Recycling of the Modified Desferrichrome AN - 227112383 AB - The uptake of iron into Pseudomonas aeruginosa is mediated by two major siderophores produced by the bacterium, pyoverdine and pyochelin. The bacterium is also able of utilize several heterologous siderophores of bacterial or fungal origin. In this work, we have investigated the iron uptake in P. aeruginosa PAO1 by the heterologous ferrichrome siderophore. ... uptake assays showed that ferrichrome is transported across the outer membrane primarily (80%) by the FiuA receptor and to a lesser extent (20%) by a secondary transporter. Moreover, we demonstrate that like in the uptake of ferripyoverdine and ferripyochelin, the energy required for both pathways of ferrichrome uptake is provided by the inner membrane protein TonB1. Desferrichrome-... uptake in P. aeruginosa was also dependent on the expression of the permease FiuB, suggesting that this protein is the inner membrane transporter of the ferrisiderophore. A biomimetic fluorescent analogue of ferrichrome, RL1194, was used in vivo to monitor the kinetics of iron release from ferrichrome in P. aeruginosa in real time. This dissociation involves acylation of ferrichrome and its biomimetic analogue RL1194 and recycling of both modified siderophores into the extracellular medium. FiuC, an N-acetyltransferase, is certainly involved in this mechanism of iron release, since its mutation abolished desferrichrome-... uptake. The acetylated derivative reacts with iron in the extracellular medium and is able to be taken up again by the cells. All these observations are discussed in light of the current knowledge concerning ferrichrome uptake in P. aeruginosa and in Escherichia coli. (ProQuest: ... denotes formulae/symbols omitted.) JF - Journal of Bacteriology AU - Hannauer, Mélissa AU - Barda, Yaniv AU - Mislin, Gaëtan L A AU - Shanzer, Abraham AU - Schalk, Isabelle J Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1212 CY - Washington PB - American Society for Microbiology VL - 192 IS - 5 SN - 00219193 KW - Medical Sciences KW - Bacteria KW - Bacteriology KW - Iron KW - Membranes KW - E coli KW - Cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/227112383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asciencejournals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Ferrichrome+Uptake+Pathway+in+Pseudomonas+aeruginosa+Involves+an+Iron+Release+Mechanism+with+Acylation+of+the+Siderophore+and+Recycling+of+the+Modified+Desferrichrome&rft.au=Hannauer%2C+M%C3%A9lissa%3BBarda%2C+Yaniv%3BMislin%2C+Ga%C3%ABtan+L+A%3BShanzer%2C+Abraham%3BSchalk%2C+Isabelle+J&rft.aulast=Hannauer&rft.aufirst=M%C3%A9lissa&rft.date=2010-03-01&rft.volume=192&rft.issue=5&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Society for Microbiology Mar 2010 N1 - Last updated - 2014-05-20 N1 - CODEN - JOBAAY ER - TY - JOUR T1 - Comparison of immunoassay and HPLC-MS/MS used to measure urinary metabolites of atrazine, metolachlor, and chlorpyrifos from farmers and non-farmers in Iowa AN - 21508809; 12503153 AB - Urine samples were collected from 51 participants in a study investigating pesticide exposure among farm families in Iowa. Aliquots from the samples were sent to two different labs and analyzed for metabolites of atrazine (atrazine mercapturate), metolachlor (metolachlor mercapturate) and chlorpyrifos (TCP) by two different analytical methods: immunoassay and high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). HPLC-MS/MS methods tend to be highly specific, but are costly and time consuming. Immunoassay methods are cheaper and faster, but can be less sensitive due to cross reactivity and matrix effects. Three statistical methods were employed to compare the two analytical methods. Each statistical method differed in how the samples that had results below the limit of detection (LOD) were treated. The first two methods involved an imputation procedure and the third method used maximum likelihood estimation (MLE). A fourth statistical method that modeled each lab separately using MLE was used for comparison. The immunoassay and HPLC-MS/MS methods were moderately correlated (correlation 0.40-0.49), but the immunoassay methods consistently had significantly higher geometric mean (GM) estimates for each pesticide metabolite. The GM estimates for atrazine mercapturate, metolachlor mercapturate, and TCP by immunoassay ranged from 0.16-0.98kgl super(-1), 0.24-0.45kgl super(-1) and 14-14kgl super(-1), respectively and by HPLC-MS/MS ranged from 0.0015-0.0039kgl super(- 1), 0.12-0.16kgl super(-1), and 2.9-3.0kgl super(-1), respectively. Immunoassays tend to be cheaper and faster than HPLC-MS/MS, however, they may result in an upward bias of urinary pesticide metabolite levels. JF - Journal of Exposure Science and Environmental Epidemiology AU - Curwin, Brian D AU - Hein, Misty J AU - Barr, Dana B AU - Striley, Cynthia AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio, USA Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 205 EP - 212 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 20 IS - 2 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - High-performance liquid chromatography KW - Statistics KW - Farms KW - Mass spectrometry KW - Metabolites KW - Mass spectroscopy KW - farms KW - Economics KW - Occupational exposure KW - Metolachlor KW - Mathematical models KW - Herbicides KW - Chlorpyrifos KW - USA, Iowa KW - Liquid chromatography KW - Urine KW - Atrazine KW - Pesticides KW - Immunoassays KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21508809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Comparison+of+immunoassay+and+HPLC-MS%2FMS+used+to+measure+urinary+metabolites+of+atrazine%2C+metolachlor%2C+and+chlorpyrifos+from+farmers+and+non-farmers+in+Iowa&rft.au=Curwin%2C+Brian+D%3BHein%2C+Misty+J%3BBarr%2C+Dana+B%3BStriley%2C+Cynthia&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2010-03-01&rft.volume=20&rft.issue=2&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2009.15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Chlorpyrifos; Metolachlor; Mathematical models; Farms; Statistics; Urine; Pesticides; Atrazine; Metabolites; Immunoassays; Mass spectroscopy; Liquid chromatography; farms; Economics; Mass spectrometry; Herbicides; Occupational exposure; USA, Iowa DO - http://dx.doi.org/10.1038/jes.2009.15 ER - TY - JOUR T1 - Impact of Azithromycin Resistance Mutations on the Virulence and Fitness of Chlamydia caviae in Guinea Pigs AN - 21499542; 12495875 AB - Azithromycin (AZM) is a major drug used in the treatment and prophylaxis of infections caused by Chlamydia, yet no significant clinical resistance has been reported for these obligate intracellular bacteria. Nevertheless, spontaneous AZM resistance (Azmr) arose in vitro at frequencies ranging from 3 x 10-8 to 8 x 10-10 for clonal isolates of Chlamydia caviae, which is a natural pathogen of guinea pigs. Sequencing of the unique 23S rRNA gene copy in 44 independent Azmr isolates identified single mutations at position A2058 or A2059 (Escherichia coli numbering system). While SP6AZ1 (A2058C) and SP6AZ2 (A2059C) Azmr mutants showed growth defects in cell culture and were less pathogenic in the guinea pig ocular infection model than in the parent SP6, the three isogenic C. caviae isolates grew equally well in the animal. On the other hand, coinoculation of the C. caviae parent strain with one of the Azmr strains was detrimental for the mutant strain. This apparent lack of association between pathology and bacterial load in vivo showed that virulence of the two Azmr mutants of C. caviae was attenuated. While chlamydial growth in vitro reflects the ability of the bacteria to multiply in permissive cells, survival in the host is a balance between cellular multiplication and clearance by the host immune system. The obligate intracellular nature of Chlamydia may therefore limit emergence of resistance in vivo due to the strength of the immune response induced by the wild-type antibiotic-sensitive bacteria at the time of antibiotic treatment. JF - Antimicrobial Agents & Chemotherapy AU - Binet, Rachel AU - Bowlin, Anne K AU - Maurelli, Anthony T AU - Rank, Roger G AD - Department of Microbiology and Immunology, F. Edward Hebert School of Medicine Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, rachel.binet@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1094 EP - 1101 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Fitness KW - Cell survival KW - rRNA 23S KW - Permissive cells KW - Animal models KW - Antibiotics KW - Cell culture KW - Pathogens KW - Infection KW - Virulence KW - rRNA KW - Azithromycin KW - Escherichia coli KW - Prophylaxis KW - Immune response KW - Mutation KW - Chlamydia KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21499542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Impact+of+Azithromycin+Resistance+Mutations+on+the+Virulence+and+Fitness+of+Chlamydia+caviae+in+Guinea+Pigs&rft.au=Binet%2C+Rachel%3BBowlin%2C+Anne+K%3BMaurelli%2C+Anthony+T%3BRank%2C+Roger+G&rft.aulast=Binet&rft.aufirst=Rachel&rft.date=2010-03-01&rft.volume=54&rft.issue=3&rft.spage=1094&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01321-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Cell survival; Fitness; Permissive cells; rRNA 23S; Animal models; Cell culture; Antibiotics; Pathogens; Infection; Virulence; rRNA; Azithromycin; Prophylaxis; Immune response; Mutation; Escherichia coli; Chlamydia DO - http://dx.doi.org/10.1128/AAC.01321-09 ER - TY - JOUR T1 - Single Nucleotide Polymorphism Analysis of the Major Tripartite Multidrug Efflux Pump of Escherichia coli: Functional Conservation in Disparate Animal Reservoirs despite Exposure to Antimicrobial Chemotherapy , AN - 21495566; 12495855 AB - AcrAB-TolC imparts a strong intrinsic resistance phenotype to many clinically significant molecules in Escherichia coli. This complex is composed of a pump, AcrB, and a periplasmic protein, AcrA, that exports substrates through a common outer membrane porin, TolC. A sequence survey of the pump-specific components, acrA and acrB, was conducted on three discrete animal reservoirs: rodents, bovines, and catfish. Although two of the reservoirs (bovine and catfish) were agrarian, and antibiotic use (ceftiofur and oxytetracycline/Romet 30, respectively) was reported for them, the vast majority of structural polymorphisms were silent except for T104A (AcrA) and Q733R (AcrB), found in certain bovine-derived strains. Overall, the genes were well conserved, with high ratios of synonymous to nonsynonymous substitutions (dS/dN ratios), consistent with or, in the case of acrB, better than those of standard multilocus sequence typing (MLST) loci. Furthermore, predicted recombination points from single nucleotide polymorphism (SNP) patterns in acrB support a modular evolution of transporter proteins, consistent with an ancient origin. However, functional studies with clones representing the major silent SNPs and the nonsilent mutation in acrB failed to generate significant differences in resistance to a range of common efflux pump substrates. Interestingly, a comparison between log-phase acrA and acrB expression profiles yielded inconsistent trends, with acrB expression increasing modestly (<1.8-fold) in many strains from the antibiotic-enriched pools. Our results suggest that structural polymorphisms in this major efflux pump system may not contribute significantly to adaptive resistance by altering function or substrate specificity but may have a potential use in improving phylogenetic relationships and/or source tracking. JF - Antimicrobial Agents & Chemotherapy AU - Elkins, Christopher A AU - Mullis, Lisa B AU - Lacher, David W AU - Jung, Carina M AD - Division of Molecular Biology, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, Maryland 20708, chris.elkins@fda.hhs.gov Y1 - 2010/03// PY - 2010 DA - Mar 2010 SP - 1007 EP - 1015 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Protein transport KW - Porins KW - Chemotherapy KW - Outer membranes KW - Substrate specificity KW - Antibiotics KW - Oxytetracycline KW - Antimicrobial agents KW - multilocus sequence typing KW - Recombination KW - Single-nucleotide polymorphism KW - Escherichia coli KW - Conservation KW - Mutation KW - Evolution KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21495566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Single+Nucleotide+Polymorphism+Analysis+of+the+Major+Tripartite+Multidrug+Efflux+Pump+of+Escherichia+coli%3A+Functional+Conservation+in+Disparate+Animal+Reservoirs+despite+Exposure+to+Antimicrobial+Chemotherapy+%2C&rft.au=Elkins%2C+Christopher+A%3BMullis%2C+Lisa+B%3BLacher%2C+David+W%3BJung%2C+Carina+M&rft.aulast=Elkins&rft.aufirst=Christopher&rft.date=2010-03-01&rft.volume=54&rft.issue=3&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01126-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Phylogeny; Protein transport; Chemotherapy; Porins; Outer membranes; Substrate specificity; Antibiotics; Oxytetracycline; multilocus sequence typing; Antimicrobial agents; Recombination; Single-nucleotide polymorphism; Conservation; Mutation; Evolution; Escherichia coli DO - http://dx.doi.org/10.1128/AAC.01126-09 ER - TY - JOUR T1 - Effects of processing on detection and quantification of the parvalbumin gene in Atlantic salmon (Salmo salar) AN - 21090252; 11185231 AB - Consumption of Atlantic salmon is a common cause of fish allergies with parvalbumin (Sal s1) being the major allergen. The presence of DNA encoding Sal s1 indicates the presence of Atlantic salmon in food. Using real-time polymerase chain reaction (PCR), the effects of food processing on the ability to detect and quantify the Sal s1 gene were determined. The method was specific for salmon and did not cross-react with 53 other species. Baking and pressure cooking caused a 5-100-fold decrease in detectable copies of the Sal s1 gene. Despite a 98% reduction in detectable copies following pressure cooking for 60 min, the relative standard deviation (RSD) between replicates was 20% and the response was 100-fold grater than the lowest copy number of Sal s1 reliably detected by the assay. Despite efforts to develop a quantitative assay, the PCR assay was qualitative. It is impossible to predict the effects of food matrices not included in this study, some of which may affect the reliability of the assay. Analyses of raw and pressure cooked salmon using a commercial PCR kit indicated comparable results to the PCR assay. JF - Food Chemistry AU - Garber, Sabine Hildebrandt andEric AE AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, Division of Bioanalytical Chemistry, HFS-716, 5100 Paint Branch Parkway, College Park, MD 20740, USA, Eric.Garber@fda.hhs.gov Y1 - 2010/03/01/ PY - 2010 DA - 2010 Mar 01 SP - 75 EP - 80 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 119 IS - 1 SN - 0308-8146, 0308-8146 KW - Oceanic Abstracts; Genetics Abstracts; ASFA Marine Biotechnology Abstracts; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts KW - Food processing KW - Marine KW - Nucleotide sequence KW - Anadromous species KW - Salmo salar KW - copy number KW - Marine fish KW - Baking KW - Population genetics KW - Hypersensitivity KW - Standard deviation KW - Genes KW - Food technology KW - Allergens KW - Cooking KW - DNA KW - Polymerase chain reaction KW - Pressure KW - Commercial species KW - Parvalbumin KW - S1 gene KW - Q1 08345:Genetics and evolution KW - Q4 27740:Products KW - O 5040:Processing, Products and Marketing KW - G 07840:Fish KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21090252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Chemistry&rft.atitle=Effects+of+processing+on+detection+and+quantification+of+the+parvalbumin+gene+in+Atlantic+salmon+%28Salmo+salar%29&rft.au=Garber%2C+Sabine+Hildebrandt+andEric+AE&rft.aulast=Garber&rft.aufirst=Sabine+Hildebrandt+andEric&rft.date=2010-03-01&rft.volume=119&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Food+Chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2009.05.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2014-05-05 N1 - SubjectsTermNotLitGenreText - Marine fish; Population genetics; Food technology; Genes; Anadromous species; Nucleotide sequence; DNA; Polymerase chain reaction; Commercial species; Food processing; Baking; Hypersensitivity; Standard deviation; Allergens; Cooking; Pressure; Parvalbumin; copy number; S1 gene; Salmo salar; Marine DO - http://dx.doi.org/10.1016/j.foodchem.2009.05.074 ER - TY - CPAPER T1 - Sensitization to Soy Antigens in Workers at a Soy Plant T2 - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AN - 742800440; 5695366 JF - 2010 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2010) AU - Green, B AU - Cummings, K AU - Gaughan, D AU - Blachere, F AU - Bledsoe, T AU - Hettick, J AU - Siegel, P AU - Kullman, G AU - Kreiss, K AU - Cox-Ganser, J AU - Beezhold, D Y1 - 2010/02/26/ PY - 2010 DA - 2010 Feb 26 KW - Soybeans KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742800440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.atitle=Sensitization+to+Soy+Antigens+in+Workers+at+a+Soy+Plant&rft.au=Green%2C+B%3BCummings%2C+K%3BGaughan%2C+D%3BBlachere%2C+F%3BBledsoe%2C+T%3BHettick%2C+J%3BSiegel%2C+P%3BKullman%2C+G%3BKreiss%2C+K%3BCox-Ganser%2C+J%3BBeezhold%2C+D&rft.aulast=Green&rft.aufirst=B&rft.date=2010-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.jacionline.org/webfiles/images/journals/ymai/Scientific_Pro LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - JOUR T1 - Breakout session summary from AAPS/CRS joint workshop on critical variables in the in vitro and in vivo performance of parenteral sustained release products. AN - 733941927; 19808069 AB - Parenteral drug delivery systems can be designed to provide the flexible delivery characteristics needed in an evolving therapeutic landscape. The goal of some parenteral formulations is to maintain effective drug concentrations over a period of months or years, thereby enhancing patient compliance. When functioning as intended, these formulations can be used to minimize undesirable effects that may occur in response to the fluctuating drug concentrations effected by immediate release products. In other cases, targeted parenteral delivery systems allow for the deposition of drug directly to its site of action, thereby minimizing systemic toxicity. While these novel formulations can be beneficial to both human and veterinary patients, disastrous effects can occur if there is an unanticipated change in product quality or performance. With these thoughts in mind, the Controlled Release Society (CRS) hosted a 2007 workshop entitled "In Vitro and In Vivo Considerations Associated with Parenteral Sustained Release Products". The objective of that workshop was to explore the physicochemical properties of parenteral products and the factors that could alter their in vitro and in vivo performance characteristics. The outcomes of that workshop were summarized in a Journal of Controlled Release article. In response to questions raised during that workshop, the CRS and the American Association of Pharmaceutical Scientist (AAPS) co-hosted the follow-up 2008 workshop entitled "Critical Variables in the In Vitro and In Vivo Performance of Parenteral Sustained Release Products". This 2008 workshop provided a platform for exploring the application of design space concepts to these complex pharmaceuticals, and to consider the corresponding in vitro test methods that can be used to set batch release specifications. To foster discussion, the workshop provided two afternoon breakout sessions where critical questions were explored. This manuscript captures the results of those discussions. Published by Elsevier B.V. JF - Journal of controlled release : official journal of the Controlled Release Society AU - Martinez, Marilyn N AU - Rathbone, Michael J AU - Burgess, Diane AU - Huynh, Mai AD - US Food and Drug Administration, Center for Veterinary, Medicine, Rockville, MD 20855, United States. marilyn.martinez@fda.hhs.gov Y1 - 2010/02/25/ PY - 2010 DA - 2010 Feb 25 SP - 2 EP - 7 VL - 142 IS - 1 KW - Index Medicus KW - Animals KW - Education KW - Humans KW - Quality Control KW - Drug Design KW - Drug Delivery Systems -- standards KW - Infusions, Parenteral -- methods KW - Infusions, Parenteral -- standards KW - Drug Delivery Systems -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733941927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+controlled+release+%3A+official+journal+of+the+Controlled+Release+Society&rft.atitle=Breakout+session+summary+from+AAPS%2FCRS+joint+workshop+on+critical+variables+in+the+in+vitro+and+in+vivo+performance+of+parenteral+sustained+release+products.&rft.au=Martinez%2C+Marilyn+N%3BRathbone%2C+Michael+J%3BBurgess%2C+Diane%3BHuynh%2C+Mai&rft.aulast=Martinez&rft.aufirst=Marilyn&rft.date=2010-02-25&rft.volume=142&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Journal+of+controlled+release+%3A+official+journal+of+the+Controlled+Release+Society&rft.issn=1873-4995&rft_id=info:doi/10.1016%2Fj.jconrel.2009.09.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-04 N1 - Date created - 2010-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.jconrel.2009.09.028 ER - TY - JOUR T1 - Review of Oncology and Hematology Drug Product Approvals at the US Food and Drug Administration Between July 2005 and December 2007 AN - 746160495; 13113210 AB - Background The Office of Oncology Drug Products (OODP) in the Center for Drug Evaluation and Research at the US Food and Drug Administration began reviewing marketing applications for oncological and hematologic indications in July 2005. We conducted an overview of products that were reviewed by the OODP for marketing approval and the regulatory actions taken during July 2005 to December 2007. Methods We identified all applications that were reviewed by the OODP from July 1, 2005, through December 31, 2007, and reviewed the actions that OODP took. We also sought the basis for the actions taken, including the clinical trial design, endpoints used, patient accrual in the trial(s) supporting approval, and the type of regulatory approval. Results During the study period, the OODP reviewed marketing applications for 60 new indications and took regulatory action on 58 indications. Regulatory action was based on a risk-benefit evaluation of the data submitted with each application. Products that demonstrated efficacy and had an acceptable risk-benefit ratio were granted either regular or accelerated marketing approval for use in the specific indication that was studied. Regular approval was based on endpoints that demonstrated that the drug provided clinical benefit as evidenced by a longer or better life or a favorable effect on an established surrogate for a longer or better life. Accelerated approval was based on a less well-established surrogate endpoint that was reasonably likely to predict a longer or better life. Of the 53 new indications that were approved during the study period, 39 received regular approval, nine received accelerated approval, and five were converted from accelerated to regular approval. Five applications were not approved, and two applications were withdrawn before any regulatory action was taken. Eighteen of the 53 indications that were approved were for new molecular entities. Conclusion During the study period, regulatory action was taken on 58 of the 60 marketing applications. Fifty-three applications were approved. A variety of clinical trial endpoints were used in the approval trials. JF - Journal of the National Cancer Institute AU - Sridhara, Rajeshwari AU - Johnson, John R AU - Justice, Robert AU - Keegan, Patricia AU - Chakravarty, Aloka AU - Pazdur, Richard AD - Affiliations of authors: Division of Biometrics V, Office of Translational Sciences (RS, AC) and Office of Oncology Drug Products (JRJ, RJ, PK, RP), Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, MD, rajeshwari.sridhara@fda.hhs.gov Y1 - 2010/02/24/ PY - 2010 DA - 2010 Feb 24 SP - 230 EP - 243 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 102 IS - 4 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Health & Safety Science Abstracts KW - USA KW - marketing KW - Reviews KW - Hematology KW - clinical trials KW - Drugs KW - Cancer KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746160495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Review+of+Oncology+and+Hematology+Drug+Product+Approvals+at+the+US+Food+and+Drug+Administration+Between+July+2005+and+December+2007&rft.au=Sridhara%2C+Rajeshwari%3BJohnson%2C+John+R%3BJustice%2C+Robert%3BKeegan%2C+Patricia%3BChakravarty%2C+Aloka%3BPazdur%2C+Richard&rft.aulast=Sridhara&rft.aufirst=Rajeshwari&rft.date=2010-02-24&rft.volume=102&rft.issue=4&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjp515 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - marketing; Reviews; Hematology; clinical trials; Drugs; Cancer; USA DO - http://dx.doi.org/10.1093/jnci/djp515 ER - TY - CPAPER T1 - The Us Niosh Nanotechnology Research Program: Meeting the Challenge for a Safer Workplace T2 - 2010 International Conference On Nanoscience and Nanotechnology (ICONN 2010) AN - 742806481; 5684633 JF - 2010 International Conference On Nanoscience and Nanotechnology (ICONN 2010) AU - Geraci, Chuck Y1 - 2010/02/22/ PY - 2010 DA - 2010 Feb 22 KW - Nanotechnology KW - Research programs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742806481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+International+Conference+On+Nanoscience+and+Nanotechnology+%28ICONN+2010%29&rft.atitle=The+Us+Niosh+Nanotechnology+Research+Program%3A+Meeting+the+Challenge+for+a+Safer+Workplace&rft.au=Geraci%2C+Chuck&rft.aulast=Geraci&rft.aufirst=Chuck&rft.date=2010-02-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+International+Conference+On+Nanoscience+and+Nanotechnology+%28ICONN+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ausnano.net/iconn2010/program.php LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-17 N1 - Last updated - 2010-08-14 ER - TY - CPAPER T1 - Progress in the development of reliable non-animal assays for the saxitoxins T2 - 61st Pacific Fisheries Technologists Conference (PFT 2010) AN - 42371079; 5666682 JF - 61st Pacific Fisheries Technologists Conference (PFT 2010) AU - Hall, Sherwood Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Saxitoxin KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.atitle=Progress+in+the+development+of+reliable+non-animal+assays+for+the+saxitoxins&rft.au=Hall%2C+Sherwood&rft.aulast=Hall&rft.aufirst=Sherwood&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pftfish.net/program.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FDA Imports Update T2 - 61st Pacific Fisheries Technologists Conference (PFT 2010) AN - 42367519; 5666747 JF - 61st Pacific Fisheries Technologists Conference (PFT 2010) AU - Shelman, Malinda Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Imports KW - FDA KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42367519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.atitle=FDA+Imports+Update&rft.au=Shelman%2C+Malinda&rft.aulast=Shelman&rft.aufirst=Malinda&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pftfish.net/program.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Food Registry T2 - 61st Pacific Fisheries Technologists Conference (PFT 2010) AN - 42365916; 5666748 JF - 61st Pacific Fisheries Technologists Conference (PFT 2010) AU - Bennett, Alan Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Food KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42365916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.atitle=Food+Registry&rft.au=Bennett%2C+Alan&rft.aulast=Bennett&rft.aufirst=Alan&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=61st+Pacific+Fisheries+Technologists+Conference+%28PFT+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pftfish.net/program.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Animal Rule:Vaccine Efficacy Studies Using Animals T2 - 8th ASM Biodefense and Emerging Diseases Research Meeting AN - 42343401; 5658449 JF - 8th ASM Biodefense and Emerging Diseases Research Meeting AU - Burns, Drusilla Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42343401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=The+Animal+Rule%3AVaccine+Efficacy+Studies+Using+Animals&rft.au=Burns%2C+Drusilla&rft.aulast=Burns&rft.aufirst=Drusilla&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/images/stories/scientific_section_proof_3 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of the Animal Rule for Licensure of Novel West Nile Vaccines T2 - 8th ASM Biodefense and Emerging Diseases Research Meeting AN - 42341586; 5658451 JF - 8th ASM Biodefense and Emerging Diseases Research Meeting AU - Markoff, Lewis Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42341586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Use+of+the+Animal+Rule+for+Licensure+of+Novel+West+Nile+Vaccines&rft.au=Markoff%2C+Lewis&rft.aulast=Markoff&rft.aufirst=Lewis&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/images/stories/scientific_section_proof_3 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polio T2 - 8th ASM Biodefense and Emerging Diseases Research Meeting AN - 42340423; 5658752 JF - 8th ASM Biodefense and Emerging Diseases Research Meeting AU - Chumakov, Konstantin Y1 - 2010/02/21/ PY - 2010 DA - 2010 Feb 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42340423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.atitle=Polio&rft.au=Chumakov%2C+Konstantin&rft.aulast=Chumakov&rft.aufirst=Konstantin&rft.date=2010-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+ASM+Biodefense+and+Emerging+Diseases+Research+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.asmbiodefense.org/images/stories/scientific_section_proof_3 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring the Global Genomic Landscape of Enteric Pathogens: Genes, INDELs, SNPs-n-Chips T2 - Seventh Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2010) AN - 42366540; 5664538 JF - Seventh Annual Conference of the MidSouth Computational Biology and Bioinformatics Society (MCBIOS 2010) AU - Jackson, Scott AU - Patel, Isha AU - Mammel, Mark AU - leClerc, Joseph Y1 - 2010/02/19/ PY - 2010 DA - 2010 Feb 19 KW - Pathogens KW - Landscape KW - Genomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42366540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventh+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2010%29&rft.atitle=Exploring+the+Global+Genomic+Landscape+of+Enteric+Pathogens%3A+Genes%2C+INDELs%2C+SNPs-n-Chips&rft.au=Jackson%2C+Scott%3BPatel%2C+Isha%3BMammel%2C+Mark%3BleClerc%2C+Joseph&rft.aulast=Jackson&rft.aufirst=Scott&rft.date=2010-02-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventh+Annual+Conference+of+the+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.mcbios.org/conference/2010/conferenceProgram.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Decomposition of Two-Component Ultrasound Pulses in Cancellous Bone Using Modified Least Squares Prony Method - Phantom Experiment and Simulation AN - 883037500; 15371008 AB - Porous media such as cancellous bone often support the simultaneous propagation of two compressional waves. When small bone samples are interrogated in through-transmission with broadband sources, these two waves often overlap in time. The modified least-squares Prony's (MLSP) method was tested for decomposing a 500 kHz-center-frequency signal containing two overlapping components: one passing through a polycarbonate plate (to produce the "fast" wave) and another passing through a cancellous-bone-mimicking phantom (to produce the "slow" wave). The MLSP method yielded estimates of attenuation slopes accurate to within 7% (polycarbonate plate) and 2% (cancellous bone phantom). The MLSP method yielded estimates of phase velocities accurate to within 1.5% (both media). The MLSP method was also tested on simulated data generated using attenuation slopes and phase velocities corresponding to bovine cancellous bone. Throughout broad ranges of signal-to-noise ratio (SNR), the MLSP method yielded estimates of attenuation slope that were accurate to within 1.0% and estimates of phase velocity that were accurate to within 4.3% (fast wave) and 1.3% (slow wave). JF - Ultrasound in Medicine & Biology AU - Wear, Keith A AD - U.S. Food and Drug Administration, Silver Spring, MD, USA, keith.wear@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 276 EP - 287 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 36 IS - 2 SN - 0301-5629, 0301-5629 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Bone (cancellous) KW - Data processing KW - Decomposition KW - Ultrasound KW - Waves KW - polycarbonate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883037500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Medicine+%26+Biology&rft.atitle=Decomposition+of+Two-Component+Ultrasound+Pulses+in+Cancellous+Bone+Using+Modified+Least+Squares+Prony+Method+-+Phantom+Experiment+and+Simulation&rft.au=Wear%2C+Keith+A&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2010-02-01&rft.volume=36&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Medicine+%26+Biology&rft.issn=03015629&rft_id=info:doi/10.1016%2Fj.ultrasmedbio.2009.06.1092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Data processing; Bone (cancellous); Waves; Decomposition; Ultrasound; polycarbonate DO - http://dx.doi.org/10.1016/j.ultrasmedbio.2009.06.1092 ER - TY - JOUR T1 - Aerosols Emitted in Underground Mine Air by Diesel Engine Fueled with Biodiesel AN - 746301439; 12646081 AB - Using biodiesel in place of petroleum diesel is considered by several underground metal and nonmetal mine operators to be a viable strategy for reducing the exposure of miners to diesel particulate matter. This study was conducted in an underground experimental mine to evaluate the effects of soy methyl ester biodiesel on the concentrations and size distributions of diesel aerosols and nitric oxides in mine air. The objective was to compare the effects of neat and blended biodiesel fuels with those of ultralow sulfur petroleum diesel. The evaluation was performed using a mechanically controlled, naturally aspirated diesel engine equipped with a muffler and a diesel oxidation catalyst. The effects of biodiesel fuels on size distributions and number and total aerosol mass concentrations were found to be strongly dependent on engine operating conditions. When fueled with biodiesel fuels, the engine contributed less to elemental carbon concentrations for all engine operating modes and exhaust configurations. The substantial increases in number concentrations and fraction of organic carbon (OC) in total carbon over the baseline were observed when the engine was fueled with biodiesel fuels and operated at light-load operating conditions. Size distributions for all test conditions were found to be single modal and strongly affected by engine operating conditions, fuel type, and exhaust configuration. The peak and total number concentrations as well as median diameter decreased with an increase in the fraction of biodiesel in the fuels, particularly for highload operating conditions. The effects of the diesel oxidation catalyst, commonly deployed to counteract the potential increase in OC emissions due to use of biodiesel, were found to vary depending upon fuel formulation and engine operating conditions. The catalyst was relatively effective in reducing aerosol number and mass concentrations, particularly at light-load conditions, but also showed the potential for an increase in nitrogen dioxide concentrations at high-load modes. JF - Journal of the Air & Waste Management Association AU - Bugarski, Aleksandar D AU - Cauda, Emanuele G AU - Janisko, Samuel J AU - Hummer, Jon A AU - Patts, Larry D AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory, Pittsburgh, PA Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 14 PB - Air & Waste Management Association, One Gateway Center, 3rd Fl Pittsburgh PA 15222-1435 USA, [mailto:info@awma.org], [URL:http://www.awma.org] VL - 60 IS - 2 SN - 1096-2247, 1096-2247 KW - Toxicology Abstracts; Environment Abstracts; Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Sustainability Science Abstracts KW - Sulfur KW - Fuels KW - Organic carbon KW - Particulate matter KW - Particulates KW - Atmospheric pollution by diesel engines KW - Nitrogen dioxide concentration KW - Nitrogen dioxide KW - Carbon KW - Petroleum KW - Catalysts KW - Exhaust emissions KW - Metals KW - Aerosols KW - nonmetals KW - biofuels KW - Esters KW - Mines KW - Soybeans KW - Exhausts KW - Oxidation KW - Diesel KW - Nitric oxide KW - Mining KW - Diesel engines KW - Size distribution KW - Biofuels KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746301439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Aerosols+Emitted+in+Underground+Mine+Air+by+Diesel+Engine+Fueled+with+Biodiesel&rft.au=Bugarski%2C+Aleksandar+D%3BCauda%2C+Emanuele+G%3BJanisko%2C+Samuel+J%3BHummer%2C+Jon+A%3BPatts%2C+Larry+D&rft.aulast=Bugarski&rft.aufirst=Aleksandar&rft.date=2010-02-01&rft.volume=60&rft.issue=2&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Sulfur; Metals; Aerosols; Fuels; Particulate matter; Mines; Exhausts; Soybeans; Nitrogen dioxide; Carbon; Petroleum; Oxidation; Nitric oxide; Diesel; Catalysts; Biofuels; Size distribution; Nitrogen dioxide concentration; Atmospheric pollution by diesel engines; nonmetals; Organic carbon; biofuels; Particulates; Esters; Mining; Diesel engines; Exhaust emissions ER - TY - JOUR T1 - Blood gene expression markers to detect and distinguish target organ toxicity AN - 746299794; 12599724 AB - The purpose of this study was to investigate whether the expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ toxicity induced by chemicals in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hepatotoxic (acetaminophen) or a neurotoxic (methyl parathion) chemical. Administration of acetaminophen (AP) in the rats resulted in hepatotoxicity as evidenced from elevated blood transaminase activities. Similarly, administration of methyl parathion (MP) resulted in neurotoxicity in the rats as evidenced from the inhibition of acetyl cholinesterase activity in their blood. Administration of either chemical also resulted in mild hematotoxicity in the rats. Microarray analysis of the global gene expression profile of rat blood identified distinct gene expression markers capable of detecting and distinguishing hepatotoxicity and neurotoxicity induced by AP and MP, respectively. Differential expressions of the marker genes for hepatotoxicity and neurotoxicity were detectable in the blood earlier than the appearance of the commonly used clinical markers (serum transaminases and acetyl cholinesterase). The ability of the marker genes to detect hepatotoxicity and neurotoxicity was further confirmed using the blood samples of rats administered additional hepatotoxic (thioacetamide, dimethylnitrobenzene, and carbon tetrachloride) or neurotoxic (ethyl parathion and malathion) chemicals. In summary, our results demonstrated that blood gene expression markers can detect and distinguish target organ toxicity non-invasively. JF - Molecular and Cellular Biochemistry AU - Umbright, Christina AU - Sellamuthu, Rajendran AU - Li, Shengqiao AU - Kashon, Michael AU - Luster, Michael AU - Joseph, Pius AD - Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA, pjoseph1@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 223 EP - 234 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 335 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Toxicology Abstracts KW - Peripheral blood KW - Cholinesterase KW - hepatotoxicity KW - transaminase KW - Malathion KW - Thioacetamide KW - Gene expression KW - Carbon tetrachloride KW - Neurotoxicity KW - Methyl parathion KW - Acetaminophen KW - Parathion KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746299794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Blood+gene+expression+markers+to+detect+and+distinguish+target+organ+toxicity&rft.au=Umbright%2C+Christina%3BSellamuthu%2C+Rajendran%3BLi%2C+Shengqiao%3BKashon%2C+Michael%3BLuster%2C+Michael%3BJoseph%2C+Pius&rft.aulast=Umbright&rft.aufirst=Christina&rft.date=2010-02-01&rft.volume=335&rft.issue=1-2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1007%2Fs11010-009-0272-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Gene expression; Carbon tetrachloride; Neurotoxicity; Peripheral blood; Methyl parathion; Cholinesterase; Thioacetamide; Malathion; transaminase; Acetaminophen; hepatotoxicity; Parathion DO - http://dx.doi.org/10.1007/s11010-009-0272-5 ER - TY - JOUR T1 - A Novel Hybrid Linear/Nonlinear Classifier for Two-Class Classification: Theory, Algorithm, and Applications AN - 746226136; 12875940 AB - Classifier design for a given classification task needs to take into consideration both the complexity of the classifier and the size of the dataset that is available for training the classifier. With limited training data, as often is the situation in computer-aided diagnosis of medical images, a classifier with simple structure (e.g., a linear classifier) is more robust and therefore preferred. We propose a novel two-class classifier, which we call a hybrid linear/nonlinear classifier (HLNLC), that involves two stages: the input features are linearly combined to form a scalar variable in the first stage and then the likelihood ratio of the scalar variable is used as the decision variable for classification. We first develop the theory of HLNLC by assuming that the feature data follow normal distributions. We show that the commonly used Fisher's linear discriminant function is generally not the optimal linear function in the first stage of the HLNLC. We formulate an optimization problem to solve for the optimal linear function in the first stage of the HLNLC, i.e., the linear function that maximizes the area under the receiver operating characteristic (ROC) curve of the HLNLC. For practical applications, we propose a robust implementation of the HLNLC by making a loose assumption that the two-class feature data arise from a pair of latent (rather than explicit) multivariate normal distributions. The novel hybrid classifier fills a gap between linear discriminant analysis (LDA) and quadratic discriminant analysis (QDA) in the sense that both its theoretical performance and its complexity lie between those of the LDA and those of the QDA. Simulation studies show that the hybrid linear/nonlinear classifier performs better than LDA without increasing the classifier complexity accordingly. With a finite number of training samples, the HLNLC can perform better than that of the ideal observer due to its simplicity. Finally, we demonstrate the application of the HLNLC in computer-aided diagnosis of breast lesions in ultrasound images. JF - IEEE Transactions on Medical Imaging AU - Chen, Weijie AU - Metz, Charles E AU - Giger, Maryellen L AU - Drukker, Karen AD - Office of Science and Engineering Laboratories, Division of Imaging and Applied Mathematics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Silver Spring, MD, USA Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 428 EP - 441 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 USA VL - 29 IS - 2 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Classification KW - Hybrids KW - Algorithms KW - Sensory systems KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746226136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=A+Novel+Hybrid+Linear%2FNonlinear+Classifier+for+Two-Class+Classification%3A+Theory%2C+Algorithm%2C+and+Applications&rft.au=Chen%2C+Weijie%3BMetz%2C+Charles+E%3BGiger%2C+Maryellen+L%3BDrukker%2C+Karen&rft.aulast=Chen&rft.aufirst=Weijie&rft.date=2010-02-01&rft.volume=29&rft.issue=2&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2009.2033596 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Classification; Hybrids; Algorithms; Ultrasound; Sensory systems DO - http://dx.doi.org/10.1109/TMI.2009.2033596 ER - TY - JOUR T1 - Estimating Parametric Distributions of Storage Time and Temperature of Ready-to-Eat Foods for U.S. Households AN - 746153129; 12502298 AB - Home refrigeration temperatures and product storage times are important factors for controlling the growth of Listeria monocytogenes in refrigerated ready-to-eat foods. In 2005, RTI International, in collaboration with Tennessee State University and Kansas State University, conducted a national survey of U.S. adults to characterize consumers' home storage and refrigeration practices for 10 different categories of refrigerated ready-to-eat foods. No distributions of storage time or refrigeration temperature were presented in any of the resulting publications. This study used classical parametric survival modeling to derive parametric distributions from the ?? International storage practices data set. Depending on the food category, variability in product storage times was best modeled using either exponential or Weibull distributions. The shape and scale of the distributions varied greatly depending on the food category. Moreover, the results indicated that consumers tend to keep a product that is packaged by a manufacturer for a longer period of time than a product that is packaged at retail. Refrigeration temperatures were comparable to those previously reported, with the variability in temperatures best fit using a Laplace distribution, as an alternative to the empirical distribution. In contrast to previous research, limited support was found for a correlation between storage time and temperature. The distributions provided in this study can be used to better model consumer behavior in future risk assessments. JF - Journal of Food Protection AU - Pouillot, Regis AU - Lubran, Meryl B AU - Cates, Sheryl C AU - Dennis, Sherri AD - Centerfor Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740; 2Joint Institute for Food Safety and Applied Nutrition, University of Maryland, College Park, Maryland 20740; and 3RTl International, 3040 Cornwallis Road, Research Triangle Park,North Carolina 27709, USAMS 09-338 Sherri.Dennis[AT]fda.hhs.gov. Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 312 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA VL - 73 IS - 2 SN - 0362-028X, 0362-028X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Risk Abstracts KW - Temperature effects KW - Refrigeration KW - Risk assessment KW - Listeria monocytogenes KW - Data processing KW - Food KW - Temperature KW - Survival KW - USA, Kansas KW - Food contamination KW - Models KW - Storage KW - USA, Tennessee KW - households KW - Households KW - Consumers KW - survival KW - J 02400:Human Diseases KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746153129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Protection&rft.atitle=Estimating+Parametric+Distributions+of+Storage+Time+and+Temperature+of+Ready-to-Eat+Foods+for+U.S.+Households&rft.au=Pouillot%2C+Regis%3BLubran%2C+Meryl+B%3BCates%2C+Sheryl+C%3BDennis%2C+Sherri&rft.aulast=Pouillot&rft.aufirst=Regis&rft.date=2010-02-01&rft.volume=73&rft.issue=2&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Protection&rft.issn=0362028X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Risk assessment; Refrigeration; Temperature effects; Data processing; Food; Survival; Consumers; Models; Storage; households; Households; Temperature; survival; Food contamination; Listeria monocytogenes; USA, Tennessee; USA, Kansas ER - TY - JOUR T1 - The national study to prevent blood exposure in paramedics: rates of exposure to blood AN - 746082466; 12597881 AB - Objective: The purpose of this analysis is to present incidence rates of exposure to blood among paramedics in the United States by selected variables and to compare all percutaneous exposure rates among different types of healthcare workers. Methods: A survey on blood exposure was mailed in 2002-2003 to a national sample of paramedics. Results for California paramedics were analyzed with the national sample and also separately. Results: The incidence rate for needlestick/lancet injuries was 100/1,000 employee-years [95% confidence interval (CI), 40-159] among the national sample and 26/1,000 employee-years (95% CI, 15-38) for the California sample. The highest exposure rate was for non-intact skin, 230/1,000 employee-years (95% CI, 130-329). The rate for all exposures was 465/1,000 employee-years (95% CI, 293-637). California needlestick/lancet rates, but not national, were substantially lower than rates in earlier studies of paramedics. Rates for all percutaneous injuries among paramedics were similar to the mid to high range of rates reported for most hospital-based healthcare workers. Conclusions: Paramedics in the United States are experiencing percutaneous injury rates at least as high as, and possibly substantially higher than, most hospital-based healthcare workers, as well as substantially higher rates of exposure to blood on non-intact skin. JF - International Archives of Occupational and Environmental Health AU - Boal, Winifred L AU - Leiss, Jack K AU - Ratcliffe, Jennifer M AU - Sousa, Sara AU - Lyden, Jennifer T AU - Li, Jia AU - Jagger, Janine AD - National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH, USA, wboal@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 191 EP - 199 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany VL - 83 IS - 2 SN - 0340-0131, 0340-0131 KW - Health & Safety Science Abstracts; Water Resources Abstracts KW - Blood KW - Skin KW - Injuries KW - Exposure KW - Surveys KW - USA, California KW - Medical personnel KW - SW 3030:Effects of pollution KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746082466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=The+national+study+to+prevent+blood+exposure+in+paramedics%3A+rates+of+exposure+to+blood&rft.au=Boal%2C+Winifred+L%3BLeiss%2C+Jack+K%3BRatcliffe%2C+Jennifer+M%3BSousa%2C+Sara%3BLyden%2C+Jennifer+T%3BLi%2C+Jia%3BJagger%2C+Janine&rft.aulast=Boal&rft.aufirst=Winifred&rft.date=2010-02-01&rft.volume=83&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-009-0421-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Skin; Injuries; Medical personnel; Blood; Exposure; Surveys; USA, California DO - http://dx.doi.org/10.1007/s00420-009-0421-x ER - TY - JOUR T1 - Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications AN - 746076744; 12744551 AB - Process analytical technology (PAT) has been gaining momentum in the biotech community due to the potential for continuous real-time quality assurance resulting in improved operational control and compliance. In this two part series, we address PAT as it applies to processes that produce biotech therapeutic products. In the first part, we address evolution of the underlying concepts and applications in biopharmaceutical manufacturing. We also present a literature review of applications in the areas of upstream and downstream processing to illustrate how implementation of PAT can help realize advanced approaches to ensuring product quality in real time. In the second part, we will explore similar applications in the areas of drug product manufacturing, rapid microbiology, and chemometrics as well as evolution of PAT in biotech processing. Biotechnol. Bioeng. 2010; 105: 276-284. Published 2009 Wiley Periodicals, Inc. JF - Biotechnology and Bioengineering AU - Read, E K AU - Park, J T AU - Riley, R B Shah AU - Brorson, K A AU - Rathore, A S AD - Office of Pharmaceutical Sciences, CDER, FDA, Silver Spring, Maryland, USA, asrathore@biotechcmz.com Y1 - 2010/02/01/ PY - 2010 DA - 2010 Feb 01 SP - 276 EP - 284 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 105 IS - 2 SN - 0006-3592, 0006-3592 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Quality control KW - Pharmaceuticals KW - Drugs KW - Evolution KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746076744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Process+analytical+technology+%28PAT%29+for+biopharmaceutical+products%3A+Part+I.+concepts+and+applications&rft.au=Read%2C+E+K%3BPark%2C+J+T%3BRiley%2C+R+B+Shah%3BBrorson%2C+K+A%3BRathore%2C+A+S&rft.aulast=Read&rft.aufirst=E&rft.date=2010-02-01&rft.volume=105&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.22528 L2 - http://www3.interscience.wiley.com/journal/122588939/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Quality control; Reviews; Pharmaceuticals; Drugs; Evolution DO - http://dx.doi.org/10.1002/bit.22528 ER - TY - JOUR T1 - Evaluation of Coumaphos Exposure Among Tick Eradication Workers AN - 746004458; 12580677 AB - Objective: To evaluate both the cholinesterase monitoring program and newer field methods of determining coumaphos exposure among tick eradication workers. Methods: Measured blood cholinesterase by the Ellman and field testing methods and tested urine for chlorferon pre- and postshift; conducted personal air sampling, patch sampling of clothing, and wipe sampling of hands for coumaphos. Results: Fifteen workers had normal plasma cholinesterase and acetylcholinesterase levels. No significant changes occurred pre- to postshift. High correlation was found between plasma cholinesterase and acetylcholinesterase levels by field testing and Ellman methods (r = 0.91, P < 0.01 and r = 0.63, P < 0.01, respectively). Chlorferon levels rose 4 to 6 hours after use (P < 0.01). Airborne coumaphos was detected in only one sample, in a trace amount. The majority of patch and hand wipe samples detected coumaphos. Conclusions: Dermal exposure to coumaphos resulted in significant increases in urinary metabolites of coumaphos. JF - Journal of Occupational and Environmental Medicine AU - Thomas, G A AU - Delaney, L J AU - Mueller, C AU - Page, E AD - NIOSH/CDC, 4676 Columbia Parkway, Mailstop R-10, Cincinnati, OH 45226, USA, epage@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 131 EP - 136 VL - 52 IS - 2 SN - 1076-2752, 1076-2752 KW - Pollution Abstracts KW - Urine KW - Ixodidae KW - Air sampling KW - Metabolites KW - Cholinesterase KW - Occupational exposure KW - Blood levels KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746004458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Evaluation+of+Coumaphos+Exposure+Among+Tick+Eradication+Workers&rft.au=Thomas%2C+G+A%3BDelaney%2C+L+J%3BMueller%2C+C%3BPage%2C+E&rft.aulast=Thomas&rft.aufirst=G&rft.date=2010-02-01&rft.volume=52&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181cd7e80 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Urine; Air sampling; Metabolites; Cholinesterase; Occupational exposure; Blood levels; Ixodidae DO - http://dx.doi.org/10.1097/JOM.0b013e3181cd7e80 ER - TY - JOUR T1 - An overview of developmental and reproductive toxicity risk assessment in China AN - 745978025; 12744849 AB - Development and reproductive toxicology (DART) studies in animals are integral parts of nonclinical safety evaluation of drugs. The State Food and Drug Administration (SFDA) of the People's Republic of China developed a new guideline on DART studies in 2006. This guideline is in broad agreement with ICH guideline S5A ([1994]), Detection of Toxicity to Reproduction for Medical Products, and M3, Nonclinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals. However, the new guideline on DART testing differs from ICH in some detailed requirements. This overview reviews some main specifications in China's guidelines on DART testing, and also briefly introduces the recommendations for conducting human clinical trials and marketing authorization in China. Birth Defects Res (Part B) 89:2-8, 2010. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Wang, Haixue AU - Wang, Qingli AU - Liao, Mingyang AD - Center for Drug Evaluation, State Food and Drug Administration, Beijing, China, haixue_wang@yahoo.com Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 2 EP - 8 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 89 IS - 1 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Risk assessment KW - Medical equipment KW - Reviews KW - Congenital defects KW - Pharmaceuticals KW - Drug development KW - Reproduction KW - Toxicity KW - Clinical trials KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745978025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=An+overview+of+developmental+and+reproductive+toxicity+risk+assessment+in+China&rft.au=Wang%2C+Haixue%3BWang%2C+Qingli%3BLiao%2C+Mingyang&rft.aulast=Wang&rft.aufirst=Haixue&rft.date=2010-02-01&rft.volume=89&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20218 L2 - http://www3.interscience.wiley.com/journal/123240181/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Risk assessment; Medical equipment; Reviews; Pharmaceuticals; Congenital defects; Reproduction; Drug development; Toxicity; Clinical trials DO - http://dx.doi.org/10.1002/bdrb.20218 ER - TY - JOUR T1 - A System for Recording High Fidelity Cough Sound and Airflow Characteristics AN - 745688970; 12601257 AB - Cough is considered an early sign of many respiratory diseases. Recently, there has been increased interest in measuring, analyzing, and characterizing the acoustical properties of a cough. In most cases the main focus of those studies was to distinguish between involuntary coughs and ambient sounds over a specified time period. The objective of this study was to develop a system to measure high fidelity voluntary cough sounds to detect lung diseases. To further augment the analysis capability of the system, a non-invasive flow measurement was also incorporated into the design. One of the main design considerations was to increase the fidelity of the recorded sound characteristics by increasing the signal to noise ratio of cough sounds and to minimize acoustical reflections from the environment. To accomplish this goal, a system was designed with a mouthpiece connected to a cylindrical tube. A microphone was attached near the mouthpiece so that its diaphragm was tangent to the inner surface of the cylinder. A pneumotach at the end of the tube measured the airflow generated by the cough. The system was terminated with an exponential horn to minimize sound reflections. Custom software was developed to read, process, display, record, and analyze cough sound and airflow characteristics. The system was optimized by comparing acoustical reflections and total signal to background noise ratios across different designs. Cough measurements were also collected from volunteer subjects to assess the viability of the system. Results indicate that analysis of cough characteristics has the potential to detect lung disease. JF - Annals of Biomedical Engineering AU - Goldsmith, W T AU - Mahmoud, A M AU - Reynolds, J S AU - McKinney, W G AU - Afshari, A A AU - Abaza, A A AU - Frazer, D G AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, 1095 Willowdale Road, Morgantown, WV, 26505, USA Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 469 EP - 477 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 38 IS - 2 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Horns KW - Computer programs KW - Fidelity KW - software KW - Diaphragm KW - Sound KW - Lung diseases KW - Cough KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745688970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=A+System+for+Recording+High+Fidelity+Cough+Sound+and+Airflow+Characteristics&rft.au=Goldsmith%2C+W+T%3BMahmoud%2C+A+M%3BReynolds%2C+J+S%3BMcKinney%2C+W+G%3BAfshari%2C+A+A%3BAbaza%2C+A+A%3BFrazer%2C+D+G&rft.aulast=Goldsmith&rft.aufirst=W&rft.date=2010-02-01&rft.volume=38&rft.issue=2&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-009-9830-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Horns; Computer programs; software; Fidelity; Diaphragm; Lung diseases; Sound; Cough DO - http://dx.doi.org/10.1007/s10439-009-9830-y ER - TY - JOUR T1 - Translating questionnaire items for a multi-lingual worker population: The iterative process of translation and cognitive interviews with English-, Spanish-, and Chinese-speaking workers AN - 745630712; 12739898 AB - Background The increasing ethnic diversity of the US workforce has created a need for research tools that can be used with multi-lingual worker populations. Developing multi-language questionnaire items is a complex process; however, very little has been documented in the literature. Methods Commonly used English items from the Job Content Questionnaire and Quality of Work Life Questionnaire were translated by two interdisciplinary bilingual teams and cognitively tested in interviews with English-, Spanish-, and Chinese-speaking workers. Results Common problems across languages mainly concerned response format. Language-specific problems required more conceptual than literal translations. Some items were better understood by non-English speakers than by English speakers. De-centering (i.e., modifying the English original to correspond with translation) produced better understanding for one item. Conclusions Translating questionnaire items and achieving equivalence across languages require various kinds of expertise. Backward translation itself is not sufficient. More research efforts should be concentrated on qualitative approaches to developing useful research tools. Am. J. Ind. Med. 53:194-203 2010. Published 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Fujishiro, Kaori AU - Gong, Fang AU - Baron, Sherry AU - Jacobson Jr, C Jeffery AU - Delaney, Sheli AU - Flynn, Michael AU - Eggerth, Donald E AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, kfujishiro@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 194 EP - 203 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Communications KW - Perception KW - Cognitive ability KW - Occupational safety KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745630712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Translating+questionnaire+items+for+a+multi-lingual+worker+population%3A+The+iterative+process+of+translation+and+cognitive+interviews+with+English-%2C+Spanish-%2C+and+Chinese-speaking+workers&rft.au=Fujishiro%2C+Kaori%3BGong%2C+Fang%3BBaron%2C+Sherry%3BJacobson+Jr%2C+C+Jeffery%3BDelaney%2C+Sheli%3BFlynn%2C+Michael%3BEggerth%2C+Donald+E&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2010-02-01&rft.volume=53&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20733 L2 - http://www3.interscience.wiley.com/journal/122528202/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Communications; Cognitive ability; Perception; Occupational safety; Ethnic groups DO - http://dx.doi.org/10.1002/ajim.20733 ER - TY - JOUR T1 - Using surveillance data to promote occupational health and safety policies and practice at the state level: A case study AN - 745630704; 12739897 AB - Background Following the investigation of a birth defects cluster involving migrant farmworkers employed in North Carolina and Florida, it became clear that greater efforts were needed to protect agricultural workers from pesticide exposure. Methods Documentation is drawn from peer-reviewed published articles, government reports and news accounts. Results The birth defects cluster was identified and investigated by state and federal pesticide poisoning surveillance system staff. Following the investigation, efforts were initiated to highlight pesticides as an important public health issue needing more attention. A series of subsequent events led to the creation and passage of important legislation recently enacted in North Carolina. The legislation resulted in funding to promote various activities to prevent harm from pesticides including strengthening surveillance, improving the quality of pesticide compliance inspections, and increasing and improving pesticide safety training. The legislation also broadened the coverage of anti-retaliation rules to include agricultural workers, and increased recordkeeping requirements pertaining to pesticide applications. Conclusion The important and positive impacts that can occur through surveillance activities are highlighted. As such, it is important to continue to support and improve occupational illness and injury surveillance programs. Am. J. Ind. Med. 53:188-193 2010. Published 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Calvert, Geoffrey M AU - Higgins, Sheila A AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, jac6@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 188 EP - 193 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - USA, North Carolina KW - USA, Florida KW - Injuries KW - Training KW - Migrant workers KW - Compliance KW - Poisoning KW - inspection KW - Public health KW - case studies KW - Pesticides KW - Congenital defects KW - Occupational exposure KW - Legislation KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745630704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Using+surveillance+data+to+promote+occupational+health+and+safety+policies+and+practice+at+the+state+level%3A+A+case+study&rft.au=Calvert%2C+Geoffrey+M%3BHiggins%2C+Sheila+A&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2010-02-01&rft.volume=53&rft.issue=2&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20707 L2 - http://www3.interscience.wiley.com/journal/122408525/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Injuries; Training; Migrant workers; Compliance; Poisoning; inspection; Public health; case studies; Pesticides; Congenital defects; Legislation; Occupational exposure; Occupational health; USA, North Carolina; USA, Florida DO - http://dx.doi.org/10.1002/ajim.20707 ER - TY - JOUR T1 - Surveillance of occupational health disparities: Challenges and opportunities AN - 745630678; 12739886 AB - Increasingly, the occupational health community is turning its attention to the effects of work on previously underserved populations, and researchers have identified many examples of disparities in occupational health outcomes. However, the occupational health status of some underserved worker populations is not described due to limitations in existing surveillance systems. As such, the occupational health community has identified the need to enhance and improve occupational health surveillance to describe the nature and extent of disparities in occupational illnesses and injuries (including fatalities), identify priorities for research and intervention, and evaluate trends. This report summarizes the data sources and methods discussed at an April 2008 workshop organized by NIOSH on the topic of improving surveillance for occupational health disparities. We discuss the capability of existing occupational health surveillance systems to document occupational health disparities and to provide surveillance data on minority and other underserved communities. Use of administrative data, secondary data analysis, and the development of targeted surveillance systems for occupational health surveillance are also discussed. Identifying and reducing occupational health disparities is one of NIOSH's priority areas under the National Occupational Research Agenda (NORA). Am. J. Ind. Med. 53:84-94 2010. Published 2010 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Souza, Kerry AU - Steege, Andrea L AU - Baron, Sherry L AD - Division of Surveillance, Hazard Evaluations and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), US Centers for Disease Control and Prevention (CDC), Washington, District of Columbia, ksouza@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 84 EP - 94 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - intervention KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745630678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Surveillance+of+occupational+health+disparities%3A+Challenges+and+opportunities&rft.au=Souza%2C+Kerry%3BSteege%2C+Andrea+L%3BBaron%2C+Sherry+L&rft.aulast=Souza&rft.aufirst=Kerry&rft.date=2010-02-01&rft.volume=53&rft.issue=2&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20777 L2 - http://www3.interscience.wiley.com/journal/123248908/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mortality; Injuries; intervention; Occupational health DO - http://dx.doi.org/10.1002/ajim.20777 ER - TY - JOUR T1 - Ocular and Respiratory Symptoms Among Lifeguards at a Hotel Indoor Waterpark Resort AN - 744590388; 12580687 AB - Objectives: To determine the cause of eye and respiratory irritation symptoms among lifeguards at an indoor waterpark. Methods: Investigators 1) performed environmental sampling for chloramine, endotoxin, and microbials; 2) administered symptom questionnaires; 3) reviewed ventilation system designs; and 4) reviewed water chemistry. Results: Airborne trichloramine concentrations were found at levels reported to cause irritation symptoms in other studies. Some endotoxin concentrations were found at levels associated with cough and fever in previous studies. Exposed lifeguards were significantly more likely to report work-related irritation symptoms than unexposed individuals. The ventilation system may not have provided sufficient air movement and distribution to adequately capture and remove air contaminants at deck level. No water microbes were detected, and water chemistry met state standards. Conclusions: Indoor waterparks need to control water chemistry and ensure adequate air movement and distribution to control air contaminants and reduce health symptoms. JF - Journal of Occupational and Environmental Medicine AU - Dang, B AU - Chen, L AU - Mueller, C AU - Dunn, KH AU - Almaguer, D AU - Roberts, J L AU - Otto, C S AD - Centers for Disease Control and Prevention/National Institute for Occupational Safety and Health (CDC/NIOSH), 4676 Columbia Parkway, MS-R11, Cincinnati, OH 45226, USA, Lchen4@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 207 EP - 213 VL - 52 IS - 2 SN - 1076-2752, 1076-2752 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Endotoxins KW - Environmental monitoring KW - Ventilation KW - Eye KW - water chemistry KW - hotels KW - Air pollution KW - Recreation areas KW - Reviews KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744590388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Ocular+and+Respiratory+Symptoms+Among+Lifeguards+at+a+Hotel+Indoor+Waterpark+Resort&rft.au=Dang%2C+B%3BChen%2C+L%3BMueller%2C+C%3BDunn%2C+KH%3BAlmaguer%2C+D%3BRoberts%2C+J+L%3BOtto%2C+C+S&rft.aulast=Dang&rft.aufirst=B&rft.date=2010-02-01&rft.volume=52&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181cf00d5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Air pollution; Endotoxins; Eye; Ventilation; Recreation areas; Reviews; water chemistry; Occupational exposure; hotels DO - http://dx.doi.org/10.1097/JOM.0b013e3181cf00d5 ER - TY - JOUR T1 - Inefficiency Differences between Critical Access Hospitals and Prospectively Paid Rural Hospitals AN - 743048117; 201029764 AB - The Medicare prospective payment system (PPS) contains incentives for hospitals to improve efficiency by placing them at financial risk to earn a positive margin on services rendered to Medicare patients. Concerns about the financial viability of small rural hospitals led to the implementation of the Medicare Rural Hospital Flexibility Program (Flex Program) of 1997, which allows facilities designated as critical access hospitals (CAHs) to be paid on a reasonable cost basis for inpatient and outpatient services. This article compares the cost inefficiency of CAHs with that of non-converting rural hospitals to contrast the performance of hospitals operating under the different payment systems. Stochastic frontier analysis (SFA) was used to estimate cost inefficiency. Analysis was performed on pooled time-series, cross-sectional data from thirty-four states for the period 1997-2004. Average estimated cost inefficiency was greater in CAHs (15.9 percent) than in non-converting rural hospitals (10.3 percent). Further, there was a positive association between length of time in the CAH program and estimated cost inefficiency. CAHs exhibited poorer values for a number of proxy measures for efficiency, including expenses per admission and labor productivity (full-time-equivalent employees per outpatient-adjusted admission). Non-CAH rural hospitals had a stronger correlation between cost inefficiency and operating margin than CAH facilities did. Adapted from the source document. JF - Journal of Health Politics, Policy and Law AU - Rosko, Michael D AU - Mutter, Ryan L AD - Widener University Agency for Healthcare Research and Quality Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 95 EP - 126 PB - Duke University Press, Durham NC VL - 35 IS - 1 SN - 0361-6878, 0361-6878 KW - Costs KW - Efficiency KW - Medicare KW - Patients KW - Payments KW - Hospitals KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743048117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Politics%2C+Policy+and+Law&rft.atitle=Inefficiency+Differences+between+Critical+Access+Hospitals+and+Prospectively+Paid+Rural+Hospitals&rft.au=Rosko%2C+Michael+D%3BMutter%2C+Ryan+L&rft.aulast=Rosko&rft.aufirst=Michael&rft.date=2010-02-01&rft.volume=35&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Politics%2C+Policy+and+Law&rft.issn=03616878&rft_id=info:doi/10.1215%2F03616878-2009-042 LA - English DB - Sociological Abstracts N1 - Date revised - 2010-05-10 N1 - Number of references - 58 N1 - Last updated - 2016-09-28 N1 - CODEN - JHPLDN N1 - SubjectsTermNotLitGenreText - Hospitals; Payments; Medicare; Patients; Costs; Efficiency DO - http://dx.doi.org/10.1215/03616878-2009-042 ER - TY - JOUR T1 - Nanoparticles and the immune system. AN - 734256804; 20016026 AB - Today nanotechnology is finding growing applications in industry, biology, and medicine. The clear benefits of using nanosized products in various biological and medical applications are often challenged by concerns about the lack of adequate data regarding their toxicity. One area of interest involves the interactions between nanoparticles and the components of the immune system. Nanoparticles can be engineered to either avoid immune system recognition or specifically inhibit or enhance the immune responses. We review herein reported observations on nanoparticle-mediated immunostimulation and immunosuppression, focusing on possible theories regarding how manipulation of particle physicochemical properties can influence their interaction with immune cells to attain desirable immunomodulation and avoid undesirable immunotoxicity. JF - Endocrinology AU - Zolnik, Banu S AU - González-Fernández, Africa AU - Sadrieh, Nakissa AU - Dobrovolskaia, Marina A AD - Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 458 EP - 465 VL - 151 IS - 2 KW - Liposomes KW - 0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Abridged Index Medicus KW - Index Medicus KW - Lymphocyte Activation KW - Animals KW - Infection -- immunology KW - Humans KW - Immunization -- methods KW - Immunosuppression -- methods KW - T-Lymphocytes -- immunology KW - Neoplasms -- immunology KW - Nanotechnology -- trends KW - Nanoparticles -- chemistry KW - B-Lymphocytes -- immunology KW - Immune System -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734256804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Nanoparticles+and+the+immune+system.&rft.au=Zolnik%2C+Banu+S%3BGonz%C3%A1lez-Fern%C3%A1ndez%2C+Africa%3BSadrieh%2C+Nakissa%3BDobrovolskaia%2C+Marina+A&rft.aulast=Zolnik&rft.aufirst=Banu&rft.date=2010-02-01&rft.volume=151&rft.issue=2&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2009-1082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-26 N1 - Date created - 2010-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2002 Jun 12;1590(1-3):131-9 [12063176] J Liposome Res. 2002 Feb-May;12(1-2):165-72 [12604051] Adv Drug Deliv Rev. 2003 Feb 24;55(3):329-47 [12628320] J Surg Res. 2003 Jun 1;112(1):19-25 [12873428] J Physiol Biochem. 2003 Mar;59(1):43-8 [12903904] Ann Oncol. 2003 Sep;14(9):1430-7 [12954584] Clin Exp Allergy. 2004 Feb;34(2):315-21 [14987314] J Immunol. 2004 Sep 1;173(5):3148-54 [15322175] Biomed Microdevices. 2004 Sep;6(3):191-202 [15377828] J Immunol. 1988 Jan 1;140(1):21-9 [2961807] Int J Pharm. 2008 Apr 16;354(1-2):56-62 [18083313] Eur J Immunol. 2008 May;38(5):1404-13 [18389478] Adv Drug Deliv Rev. 2008 May 22;60(8):915-28 [18325628] Adv Drug Deliv Rev. 2008 May 22;60(8):876-85 [18423779] J Gene Med. 2008 Jul;10(7):795-804 [18452240] Nat Nanotechnol. 2007 Aug;2(8):469-78 [18654343] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Mol Pharm. 2008 Jul-Aug;5(4):487-95 [18510338] PLoS One. 2008;3(8):e2954 [18698426] J Immunol. 2008 Sep 1;181(5):3301-9 [18714002] Contact Dermatitis. 2008 Aug;59(2):122-3 [18759884] Nat Immunol. 2008 Nov;9(11):1225-35 [18820683] Eur J Pharm Biopharm. 2008 Nov;70(3):711-7 [18582571] Pharm Res. 2009 Jan;26(1):72-81 [18779928] Mol Pharm. 2009 Jan-Feb;6(1):211-20 [19072654] Eur J Pharm Biopharm. 2009 Feb;71(2):161-72 [18824097] Mol Immunol. 2009 May;46(8-9):1571-2 [19286261] Toxicol Sci. 2009 May;109(1):113-23 [19293371] Adv Drug Deliv Rev. 2009 Jun 21;61(6):428-37 [19376175] Adv Drug Deliv Rev. 2009 Jun 21;61(6):422-7 [19389437] Drug Discov Today. 2009 Jun;14(11-12):541-51 [19508916] Trends Immunol. 2009 Jun;30(6):286-92 [19428302] Int J Oncol. 2009 Aug;35(2):229-38 [19578735] Nat Nanotechnol. 2009 Jul;4(7):451-6 [19581899] Fed Regist. 2012 May 18;77(97):29665-6 [22616137] Jpn J Med Sci Biol. 1991 Apr;44(2):75-80 [1956128] Pharm Biotechnol. 1995;6:463-72 [7551231] J Biomed Mater Res. 1996 Jan;30(1):53-65 [8788106] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10809-13 [9724786] Nat Med. 1999 Apr;5(4):387-91 [10202926] J Control Release. 1999 Aug 27;61(1-2):233-40 [10469918] Ann Rheum Dis. 2005 Aug;64(8):1132-6 [15695536] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Dokl Akad Nauk. 1999 Nov;369(3):411-3 [10613249] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12193-7 [11035793] Int J Pharm. 2001 Jun 19;221(1-2):57-67 [11397567] Cell. 2001 Aug 10;106(3):255-8 [11509172] Int J Pharm. 2002 Jan 14;231(2):167-76 [11755269] Arthritis Rheum. 2002 Apr;46(4):1109-20 [11953991] Dokl Biochem. 2000 Jan-Feb;370(1-6):4-7 [11977250] Toxicology. 2005 Dec 15;216(2-3):106-21 [16140450] Exp Eye Res. 2006 Apr;82(4):657-63 [16360654] Fed Regist. 2006 Apr 13;71(71):19193-4 [16612859] J Control Release. 2006 May 1;112(1):15-25 [16515818] J Biotechnol. 2006 Jul 25;124(3):602-14 [16515817] Mol Biosyst. 2005 Jul;1(2):176-82 [16880981] Nano Lett. 2006 Aug;6(8):1682-6 [16895356] Methods. 2006 Sep;40(1):20-9 [16997710] Int J Oncol. 2006 Nov;29(5):1053-64 [17016635] J Control Release. 2006 Oct 27;115(3):251-8 [17045355] J Pharm Pharmacol. 2006 Nov;58(11):1491-8 [17132212] Mol Pharm. 2007 Jan-Feb;4(1):73-84 [17274665] Nanomedicine. 2006 Sep;2(3):158-68 [17292138] Int J Oncol. 2007 Jun;30(6):1297-307 [17487349] J Control Release. 2007 Jun 4;119(2):236-44 [17399838] J Immunol. 2007 Jul 1;179(1):665-72 [17579089] Vaccine. 2007 Jul 20;25(29):5263-71 [17576025] J Liposome Res. 2007;17(2):107-17 [17613700] Cancer Chemother Pharmacol. 2007 Oct;60(5):759-66 [17285317] J Control Release. 2007 Oct 8;122(3):349-55 [17610982] Nat Biotechnol. 2007 Oct;25(10):1159-64 [17873867] Toxicol Sci. 2008 Jan;101(1):4-21 [17602205] J Control Release. 2008 Feb 11;125(3):193-209 [18083265] Clin Breast Cancer. 2007 Dec;7(11):850-6 [18269774] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1210/en.2009-1082 ER - TY - JOUR T1 - Current regulatory perspectives on genotoxicity testing for botanical drug product development in the U.S.A. AN - 733926709; 19782117 AB - Genotoxicity testing is an important part of preclinical safety assessment of new drugs and is required prior to Phase I/II clinical trials. It is designed to detect genetic damage such as gene mutations and chromosomal aberration, which may be reflected in tumorigenic or heritable mutation potential of the drug. Botanical new drugs in the U.S. are entitled to a waiver for preclinical pharmacology/toxicology studies, including genotoxicity testing, in support of an initial clinical trial under IND, contingent on previous human experience. Recently, ethical concerns have been raised over conducting Phase I/II clinical trials of new drugs with positive genotoxicity findings in healthy volunteers. Although the relevance of this issue to patients, as opposed to healthy volunteers, depends on the drug's indication, duration of treatment, and specific findings related to the assays, the regulatory view is to avoid exposing patients to genotoxic compounds unnecessarily in clinical trials. This philosophy may impact on herbal supplement marketing and botanical drug development, in that genotoxicity data are often lacking while consumers are exposed to the herbal supplement, or healthy volunteers are tested in an initial Phase I/II clinical trial on the botanical drug. This paper presents results of a survey conducted on genotoxicity data in botanical INDs submitted to the Agency and discusses the significance of this information. The information presented indicates that the sponsors of botanical INDs have increasingly recognized the importance of genotoxicity information and may have prioritized its acquisition in their strategic drug development programs. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Wu, Kuei-Meng AU - Dou, Jinhui AU - Ghantous, Hanan AU - Chen, Shaw AU - Bigger, Anita AU - Birnkrant, Debra AD - Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. kueimeng.wu@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 1 EP - 3 VL - 56 IS - 1 KW - Drugs, Investigational KW - 0 KW - Plant Preparations KW - Index Medicus KW - United States KW - Mutagenicity Tests -- statistics & numerical data KW - Humans KW - Clinical Trials as Topic -- statistics & numerical data KW - Investigational New Drug Application -- statistics & numerical data KW - Plant Preparations -- toxicity KW - Drug Approval -- statistics & numerical data KW - Therapeutic Human Experimentation KW - Drugs, Investigational -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733926709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Current+regulatory+perspectives+on+genotoxicity+testing+for+botanical+drug+product+development+in+the+U.S.A.&rft.au=Wu%2C+Kuei-Meng%3BDou%2C+Jinhui%3BGhantous%2C+Hanan%3BChen%2C+Shaw%3BBigger%2C+Anita%3BBirnkrant%2C+Debra&rft.aulast=Wu&rft.aufirst=Kuei-Meng&rft.date=2010-02-01&rft.volume=56&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2009.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-29 N1 - Date created - 2010-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.yrtph.2009.09.012 ER - TY - JOUR T1 - Understanding the genetic basis for adverse drug effects: the calcineurin inhibitors. AN - 733902629; 20099993 AB - The calcineurin inhibitors-cyclosporine and tacrolimus-are the mainstay of immunosuppressive therapy in solid organ transplantation. These drugs produce severe adverse drug effects (ADEs) such as nephrotoxicity, posttransplantation diabetes mellitus, and hypertension. Accumulated evidence suggests that the development of type 2 diabetes, hypertension, and renal failure may be associated with specific DNA genotypes. In this review, the genes involved with the development of these disease processes are compared with those implicated in calcineurin inhibitor-induced ADEs. The renin-angiotensin system genes, cytokine-encoding genes, and plasminogen activator inhibitor type 1 genes have been implicated in calcineurin inhibitor-induced nephrotoxicity, as well as in development of renal failure. A number of genes are implicated in contributing to diabetes, and these include the vitamin D receptor gene, VDR; hepatocyte nuclear factor genes, HNF; transcription factor 7-like 2 gene, TCF7L2; angiotensin-converting enzyme gene, ACE; cytokines; peroxisome proliferator-activated receptor gamma gene, PPARG; and others. Studies have suggested that the VDR, PPARG, HNF1A, and adenosine 5'-triphosphate-binding cassette ABCC8 (which encodes the sulfonylurea receptor) genes are associated with calcineurin inhibitor-induced diabetes. The genes encoding for the angiotensin-converting enzyme, endothelial constitutive nitric oxide synthase, and cytochrome P450 3A isoenzyme have been involved in the development of hypertension and in calcineurin inhibitor-induced hypertension. The genetic study of disease states can be the stepping stones for thoroughly understanding the genetic basis of ADEs. Gene polymorphisms are implicated in the development of diseases and corresponding disease-like ADEs. The disease-associated genes provide candidate genes for exploring ADEs and may provide genomic biomarkers for assessing the risk for developing severe calcineurin inhibitor-related ADEs as well as for developing preventive strategies. JF - Pharmacotherapy AU - Bai, Jane P F AU - Lesko, Lawrence J AU - Burckart, Gilbert J AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 195 EP - 209 VL - 30 IS - 2 KW - Biomarkers, Pharmacological KW - 0 KW - Calcineurin Inhibitors KW - Immunosuppressive Agents KW - Cyclosporine KW - 83HN0GTJ6D KW - Tacrolimus KW - WM0HAQ4WNM KW - Index Medicus KW - Genotype KW - Hypertension -- chemically induced KW - Renal Insufficiency -- chemically induced KW - Risk Factors KW - Humans KW - Precision Medicine -- methods KW - Hypertension -- genetics KW - Diabetes Mellitus, Type 2 -- genetics KW - Renal Insufficiency -- genetics KW - Diabetes Mellitus, Type 2 -- chemically induced KW - Drug Discovery -- methods KW - Tacrolimus -- adverse effects KW - Cyclosporine -- adverse effects KW - Polymorphism, Genetic KW - Tacrolimus -- pharmacology KW - Cyclosporine -- pharmacology KW - Immunosuppressive Agents -- pharmacology KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733902629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Understanding+the+genetic+basis+for+adverse+drug+effects%3A+the+calcineurin+inhibitors.&rft.au=Bai%2C+Jane+P+F%3BLesko%2C+Lawrence+J%3BBurckart%2C+Gilbert+J&rft.aulast=Bai&rft.aufirst=Jane+P&rft.date=2010-02-01&rft.volume=30&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=1875-9114&rft_id=info:doi/10.1592%2Fphco.30.2.195 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-22 N1 - Date created - 2010-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1592/phco.30.2.195 ER - TY - JOUR T1 - Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity. AN - 733900208; 19948201 AB - The association of kava products with liver-related health risks has prompted regulatory action in many countries. We used a genome-wide gene expression approach to generate global gene expression profiles from the livers of male B6C3F1 mice administered kava extract by gavage for 14 weeks, and identified the differentially expressed drug metabolizing genes in response to kava treatments. Analyses of gene functions and pathways reveal that the levels of significant numbers of genes involving drug metabolism were changed and that the pathways involving xenobiotics metabolism, Nrf2-mediated oxidative stress response, mitochondrial functions and others, were altered. Our results indicate that kava extract can significantly modulate drug metabolizing enzymes, potentially leading to herb-drug interactions and hepatotoxicity. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Guo, Lei AU - Shi, Qiang AU - Dial, Stacey AU - Xia, Qingsu AU - Mei, Nan AU - Li, Quan-zhen AU - Chan, Po-Chuen AU - Fu, Peter AD - Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. lei.guo@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 686 EP - 696 VL - 48 IS - 2 KW - NF-E2-Related Factor 2 KW - 0 KW - Nfe2l2 protein, mouse KW - Plant Extracts KW - RNA, Messenger KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Plant Extracts -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Mitochondria, Liver -- metabolism KW - Longevity -- drug effects KW - NF-E2-Related Factor 2 -- genetics KW - Mice KW - Mitochondria, Liver -- drug effects KW - NF-E2-Related Factor 2 -- metabolism KW - Mice, Inbred Strains KW - RNA, Messenger -- metabolism KW - Mitochondria, Liver -- genetics KW - Oxidative Stress -- drug effects KW - Plant Extracts -- toxicity KW - Female KW - Male KW - Gene Expression Profiling KW - Liver -- enzymology KW - Liver -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Kava -- metabolism KW - Kava -- toxicity KW - Inactivation, Metabolic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733900208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Gene+expression+profiling+in+male+B6C3F1+mouse+livers+exposed+to+kava+identifies--changes+in+drug+metabolizing+genes+and+potential+mechanisms+linked+to+kava+toxicity.&rft.au=Guo%2C+Lei%3BShi%2C+Qiang%3BDial%2C+Stacey%3BXia%2C+Qingsu%3BMei%2C+Nan%3BLi%2C+Quan-zhen%3BChan%2C+Po-Chuen%3BFu%2C+Peter&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2010-02-01&rft.volume=48&rft.issue=2&rft.spage=686&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2009.11.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-21 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] Toxicol Sci. 2009 May;109(1):31-40 [19246624] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] Drug Metab Dispos. 2002 Nov;30(11):1153-7 [12386118] MMWR Morb Mortal Wkly Rep. 2002 Nov 29;51(47):1065-7 [12500906] Drug Metab Dispos. 2003 May;31(5):533-9 [12695340] Phytomedicine. 2003;10 Suppl 4:68-73 [12807347] Integr Cancer Ther. 2002 Sep;1(3):287-93; discussion 293 [14667286] Fed Regist. 2004 Feb 11;69(28):6787-854 [14968803] Biochem Pharmacol. 2004 Feb 1;67(3):427-37 [15037195] J Biol Chem. 2004 May 28;279(22):23052-60 [15020583] Med J Aust. 1988 Jun 6;148(11):548-55 [3374423] Drug Metab Rev. 1994;26(1-2):165-83 [8082563] Dtsch Med Wochenschr. 1998 Nov 20;123(47):1410-4 [9856112] Chem Biol Interact. 1999 Apr 1;118(2):151-69 [10359459] Clin Pharmacol Ther. 2005 May;77(5):415-26 [15900287] Clin Pharmacol Ther. 2005 May;77(5):453-4 [15900292] Drugs. 2005;65(9):1239-82 [15916450] Drugs Aging. 2005;22(6):525-39 [15974642] J Ethnopharmacol. 2005 Aug 22;100(1-2):108-13 [16005588] Geriatrics. 2005 Sep;60(9):24-5 [16153141] Annu Rev Pharmacol Toxicol. 2006;46:41-64 [16402898] Exp Toxicol Pathol. 2007 Jan;58(4):223-36 [17059882] Annu Rev Pharmacol Toxicol. 2007;47:89-116 [16968214] Drug Metab Dispos. 2007 Feb;35(2):240-5 [17079360] Toxicol Pathol. 2007 Jun;35(4):459-73 [17562481] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007 Jul-Sep;25(3):211-44 [17763047] Drug Metab Rev. 2007;39(2-3):389-99 [17786628] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):89-112 [18322868] Mol Pharmacol. 2008 Jun;73(6):1785-95 [18334601] Food Chem Toxicol. 2008 Dec;46(12):3732-8 [18930106] Food Chem Toxicol. 2009 Feb;47(2):433-42 [19100306] Toxicol Lett. 2009 Apr 10;186(1):22-31 [18996174] Toxicol Sci. 2009 May;109(1):24-30 [19246623] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.fct.2009.11.050 ER - TY - JOUR T1 - In vitro neurotoxic properties and excitatory aminoacids concentration in the cerebrospinal fluid of amyotrophic lateral sclerosis patients. Relationship with the degree of certainty of disease diagnoses. AN - 733657184; 19804473 AB - To determine glutamate and aspartate levels in the cerebrospinal fluid (CSF) in patients with sporadic amyotrophic lateral sclerosis (SALS) grouped according to El Escorial diagnostic criteria, and to perform an in vitro assessment of the neurotoxicity of the CSF in murine cortical neurons. SALS patients were sorted according to El Escorial diagnostic criteria. Glutamate and aspartate were measured in the CSF using high performance liquid chromatography. Cultured cortical neuron viability was determined after exposure to CSF for 24 h. Glutamate levels were elevated in 28 out of the 29 patients with definite, probable or possible SALS. There were no differences in glutamate concentrations when the three clinical forms of the disease were compared; neither there were significant variation across disease duration and clinical presentation. In agreement with previous reports, we concluded that CSF-SALS-induced in vitro neurotoxicity is mediated by ionotropic glutamate receptors. We found no relationship between the degree of in vitro neurotoxicity and glutamate concentration in the CSF. Glutamate but not aspartate CSF levels may contribute to ALS pathogenesis. However, glutamate levels may not influence the degree of diagnosis certainty or lesion extension. JF - Acta neurologica Scandinavica AU - Fiszman, M L AU - Ricart, K C AU - Latini, A AU - Rodríguez, G AU - Sica, R E P AD - Instituto de Investigaciones Farmacológicas-CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina. Monica.Fiszman@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 120 EP - 126 VL - 121 IS - 2 KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - Index Medicus KW - Animals KW - Cerebral Cortex -- physiology KW - Cells, Cultured KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Mice KW - Time Factors KW - Male KW - Female KW - Cell Survival -- physiology KW - Amyotrophic Lateral Sclerosis -- diagnosis KW - Amyotrophic Lateral Sclerosis -- cerebrospinal fluid KW - Aspartic Acid -- cerebrospinal fluid KW - Neurons -- physiology KW - Cerebrospinal Fluid -- metabolism KW - Glutamic Acid -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733657184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+neurologica+Scandinavica&rft.atitle=In+vitro+neurotoxic+properties+and+excitatory+aminoacids+concentration+in+the+cerebrospinal+fluid+of+amyotrophic+lateral+sclerosis+patients.+Relationship+with+the+degree+of+certainty+of+disease+diagnoses.&rft.au=Fiszman%2C+M+L%3BRicart%2C+K+C%3BLatini%2C+A%3BRodr%C3%ADguez%2C+G%3BSica%2C+R+E+P&rft.aulast=Fiszman&rft.aufirst=M&rft.date=2010-02-01&rft.volume=121&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Acta+neurologica+Scandinavica&rft.issn=1600-0404&rft_id=info:doi/10.1111%2Fj.1600-0404.2009.01200.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-04 N1 - Date created - 2010-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1600-0404.2009.01200.x ER - TY - JOUR T1 - Whole-body inhalation exposure to 1-bromopropane suppresses the IgM response to sheep red blood cells in female B6C3F1 mice and Fisher 344/N rats. AN - 733581017; 20041805 AB - 1-Bromopropane (1-BP) is categorized as a high-production-volume chemical and is currently used in the manufacture of pharmaceuticals, pesticides, and other chemicals. Its usage is estimated to be around 5 million pounds per year, resulting in the potential for widespread exposure in the workplace. Case reports and animal studies have suggested exposure to this compound may cause adverse reproductive and neurological effects. Using a battery of immunological assays, the immunotoxicity of 1-BP after whole body inhalation exposure in both mice and rats was evaluated. Significant decreases in the spleen immunoglobulin (Ig) M response to sheep red blood cells (SRBC) were observed in both mice (125-500 ppm) and rats (1000 ppm) after exposure to 1-BP for 10 wk. In addition, total spleen cells and T cells were significantly decreased after approximately 4 wk of 1-BP exposure in both mice (125-500 ppm) and rats (1000 ppm). No change in natural killer (NK) cell activity was observed. The observed alterations in spleen cellularity, phenotypic subsets, and impairment of humoral immune function across species raise further concern about human exposure to 1-BP and demonstrate the need for additional investigations into potential adverse health effects. JF - Inhalation toxicology AU - Anderson, Stacey E AU - Munson, Albert E AU - Butterworth, Leon F AU - Germolec, Dori AU - Morgan, Daniel L AU - Roycroft, Joseph A AU - Dill, Jeffrey AU - Meade, B J AD - National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. sanderson4@cdc.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 125 EP - 132 VL - 22 IS - 2 KW - Biomarkers KW - 0 KW - Hydrocarbons, Brominated KW - Immunoglobulin M KW - 1-bromopropane KW - Y9746DNE68 KW - Index Medicus KW - Animals KW - Viral Plaque Assay KW - Immunity, Humoral -- drug effects KW - Sheep KW - Hydrocarbons, Brominated -- administration & dosage KW - Mice KW - Hydrocarbons, Brominated -- toxicity KW - Killer Cells, Natural -- drug effects KW - Rats KW - Phenotype KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Inhalation Exposure KW - Spleen -- immunology KW - T-Lymphocytes -- drug effects KW - Spleen -- drug effects KW - T-Lymphocytes -- immunology KW - Female KW - Killer Cells, Natural -- immunology KW - Immunoglobulin M -- analysis KW - Immunoglobulin M -- immunology KW - Immunoglobulin M -- biosynthesis KW - Erythrocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733581017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Whole-body+inhalation+exposure+to+1-bromopropane+suppresses+the+IgM+response+to+sheep+red+blood+cells+in+female+B6C3F1+mice+and+Fisher+344%2FN+rats.&rft.au=Anderson%2C+Stacey+E%3BMunson%2C+Albert+E%3BButterworth%2C+Leon+F%3BGermolec%2C+Dori%3BMorgan%2C+Daniel+L%3BRoycroft%2C+Joseph+A%3BDill%2C+Jeffrey%3BMeade%2C+B+J&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2010-02-01&rft.volume=22&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958370902953910 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-25 N1 - Date created - 2010-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Neurol Neurosurg. 1999 Sep;101(3):199-202 [10536908] J Occup Environ Med. 2007 Sep;49(9):1009-19 [17848857] Toxicology. 2000 Dec 7;156(1):1-11 [11162871] J Toxicol Environ Health A. 2002 Mar;65(5-6):383-94 [11936219] Environ Health Perspect. 2004 Sep;112(13):1319-25 [15345346] Physiol Rev. 1980 Oct;60(4):1107-66 [7001511] Fundam Appl Toxicol. 1988 May;10(4):701-16 [3396796] Cancer Res. 1989 Nov 1;49(21):5816-22 [2507138] J Immunol Methods. 1992 Jan 21;146(1):91-103 [1735786] Fundam Appl Toxicol. 1993 Nov;21(4):412-9 [8253294] Scand J Work Environ Health. 1996 Oct;22(5):387-91 [8923614] Scand J Work Environ Health. 1997 Aug;23(4):281-8 [9322819] Am J Ind Med. 1999 May;35(5):523-31 [10212706] J Pharm Pharmacol. 1955 May;7(5):314-27 [14368526] Science. 1963 Apr 26;140(3565):405 [13957684] Toxicol Appl Pharmacol. 2006 Aug 15;215(1):23-36 [16513153] J Toxicol Environ Health A. 2007 Aug;70(15-16):1381-90 [17654258] Toxicol Sci. 2000 May;55(1):116-23 [10788566] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.3109/08958370902953910 ER - TY - JOUR T1 - Testing computational toxicology models with phytochemicals. AN - 733564025; 20024931 AB - Computational toxicology employing quantitative structure-activity relationship (QSAR) modeling is an evidence-based predictive method being evaluated by regulatory agencies for risk assessment and scientific decision support for toxicological endpoints of interest such as rodent carcinogenicity. Computational toxicology is being tested for its usefulness to support the safety assessment of drug-related substances (e.g. active pharmaceutical ingredients, metabolites, impurities), indirect food additives, and other applied uses of value for protecting public health including safety assessment of environmental chemicals. The specific use of QSAR as a chemoinformatic tool for estimating the rodent carcinogenic potential of phytochemicals present in botanicals, herbs, and natural dietary sources is investigated here by an external validation study, which is the most stringent scientific method of measuring predictive performance. The external validation statistics for predicting rodent carcinogenicity of 43 phytochemicals, using two computational software programs evaluated at the FDA, are discussed. One software program showed very good performance for predicting non-carcinogens (high specificity), but both exhibited poor performance in predicting carcinogens (sensitivity), which is consistent with the design of the models. When predictions were considered in combination with each other rather than based on any one software, the performance for sensitivity was enhanced, However, Chi-square values indicated that the overall predictive performance decreases when using the two computational programs with this particular data set. This study suggests that complementary multiple computational toxicology software need to be carefully selected to improve global QSAR predictions for this complex toxicological endpoint. JF - Molecular nutrition & food research AU - Valerio, Luis G AU - Arvidson, Kirk B AU - Busta, Emily AU - Minnier, Barbara L AU - Kruhlak, Naomi L AU - Benz, R Daniel AD - Informatics and Computational Safety Analysis Staff, Science and Research Staff, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993-0002, USA. Luis.Valerio@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 186 EP - 194 VL - 54 IS - 2 KW - Carcinogens KW - 0 KW - Plant Preparations KW - Index Medicus KW - United States KW - Animals KW - Software KW - Mice KW - Risk Assessment -- methods KW - Models, Biological KW - Rats KW - United States Food and Drug Administration KW - Quantitative Structure-Activity Relationship KW - Databases, Factual KW - Toxicity Tests KW - Statistics as Topic KW - Female KW - Male KW - Carcinogens -- chemistry KW - Plant Preparations -- chemistry KW - Computational Biology -- methods KW - Carcinogens -- toxicity KW - Expert Systems KW - Toxicology -- methods KW - Plants, Edible -- chemistry KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733564025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=Testing+computational+toxicology+models+with+phytochemicals.&rft.au=Valerio%2C+Luis+G%3BArvidson%2C+Kirk+B%3BBusta%2C+Emily%3BMinnier%2C+Barbara+L%3BKruhlak%2C+Naomi+L%3BBenz%2C+R+Daniel&rft.aulast=Valerio&rft.aufirst=Luis&rft.date=2010-02-01&rft.volume=54&rft.issue=2&rft.spage=186&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=1613-4133&rft_id=info:doi/10.1002%2Fmnfr.200900259 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-07-01 N1 - Date created - 2010-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mnfr.200900259 ER - TY - JOUR T1 - Genetic analysis for the lack of expression of the O157 antigen in an O Rough:H7 Escherichia coli strain. AN - 733313443; 19948859 AB - The O-antigen (rfb) operon and related genes of MA6, an O rough:H7 Shiga-toxigenic Escherichia coli strain, were examined to determine the cause of the lack of O157 expression. A 1,310-bp insertion, homologous to IS629, was observed within its gne gene. trans complementation with a functional gne gene from O157:H7 restored O157 antigen expression in MA6. JF - Applied and environmental microbiology AU - Rump, Lydia V AU - Feng, Peter C H AU - Fischer, Markus AU - Monday, Steven R AD - Division of Microbiology, United States Food and Drug Administration, College Park, Maryland 20740, USA. Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 945 EP - 947 VL - 76 IS - 3 KW - Bacterial Outer Membrane Proteins KW - 0 KW - Escherichia coli Proteins KW - O Antigens KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - Genes, Bacterial KW - Bacterial Outer Membrane Proteins -- immunology KW - Bacterial Outer Membrane Proteins -- genetics KW - Operon KW - Genetic Complementation Test KW - Bacterial Outer Membrane Proteins -- metabolism KW - Mutagenesis, Insertional KW - Escherichia coli Proteins -- immunology KW - Escherichia coli Proteins -- metabolism KW - O Antigens -- metabolism KW - Escherichia coli O157 -- metabolism KW - Escherichia coli O157 -- immunology KW - Escherichia coli Proteins -- genetics KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733313443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Genetic+analysis+for+the+lack+of+expression+of+the+O157+antigen+in+an+O+Rough%3AH7+Escherichia+coli+strain.&rft.au=Rump%2C+Lydia+V%3BFeng%2C+Peter+C+H%3BFischer%2C+Markus%3BMonday%2C+Steven+R&rft.aulast=Rump&rft.aufirst=Lydia&rft.date=2010-02-01&rft.volume=76&rft.issue=3&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.02046-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-16 N1 - Date created - 2010-01-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 2001 Nov;69(11):6923-30 [11598067] FEMS Microbiol Rev. 2008 Jul;32(4):627-53 [18422615] Annu Rev Biochem. 2002;71:635-700 [12045108] Carbohydr Res. 2003 Nov 14;338(23):2503-19 [14670712] J Bacteriol. 2004 Oct;186(19):6536-43 [15375135] J Mol Biol. 1987 Aug 5;196(3):445-55 [2824781] Gene. 1993 May 15;127(1):111-5 [8387445] Microbiol Rev. 1993 Sep;57(3):655-82 [7504166] Emerg Infect Dis. 1995 Apr-Jun;1(2):47-52 [8903158] Appl Environ Microbiol. 1998 Mar;64(3):1153-6 [9501454] Infect Immun. 1998 Aug;66(8):3545-51 [9673232] J Clin Microbiol. 1998 Aug;36(8):2339-41 [9666018] Microbiol Mol Biol Rev. 1998 Sep;62(3):725-74 [9729608] Scand J Infect Dis. 1999;31(2):141-4 [10447322] Int J Med Microbiol. 2007 Feb;297(1):17-26 [17157559] J Bacteriol. 2002 May;184(10):2620-5 [11976290] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1128/AEM.02046-09 ER - TY - CPAPER T1 - Trends in Antimicrobial Resistance of Enterococcus from Retail Raw Meats in the United States: 2002-2007 T2 - 2010 Annual Conference on Antimicrobial Resistance AN - 42274553; 5622660 JF - 2010 Annual Conference on Antimicrobial Resistance AU - Tong, E AU - Kabera, C AU - Womack, N AU - Cameron, K AU - Zhao, S AU - McDermott AU - , P. Y1 - 2010/02/01/ PY - 2010 DA - 2010 Feb 01 KW - USA KW - Meat KW - Antimicrobial agents KW - Antimicrobial resistance KW - Enterococcus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42274553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Trends+in+Antimicrobial+Resistance+of+Enterococcus+from+Retail+Raw+Meats+in+the+United+States%3A+2002-2007&rft.au=Tong%2C+E%3BKabera%2C+C%3BWomack%2C+N%3BCameron%2C+K%3BZhao%2C+S%3BMcDermott%3B%2C+P.&rft.aulast=Tong&rft.aufirst=E&rft.date=2010-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of E. coli as a Sentinel for Antimicrobial Resistance in Salmonella T2 - 2010 Annual Conference on Antimicrobial Resistance AN - 42273476; 5622661 JF - 2010 Annual Conference on Antimicrobial Resistance AU - Womack, N AU - Kabera, C AU - Jones, S AU - Gaines, S AU - Tong, E AU - Zhao, S AU - McDermott, P Y1 - 2010/02/01/ PY - 2010 DA - 2010 Feb 01 KW - Antimicrobial agents KW - Antimicrobial resistance KW - Anadromous species KW - Escherichia coli KW - Salmonella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42273476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=The+Use+of+E.+coli+as+a+Sentinel+for+Antimicrobial+Resistance+in+Salmonella&rft.au=Womack%2C+N%3BKabera%2C+C%3BJones%2C+S%3BGaines%2C+S%3BTong%2C+E%3BZhao%2C+S%3BMcDermott%2C+P&rft.aulast=Womack&rft.aufirst=N&rft.date=2010-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Paper or Plastic? Bringing Resistance Home T2 - 2010 Annual Conference on Antimicrobial Resistance AN - 42272881; 5622625 JF - 2010 Annual Conference on Antimicrobial Resistance AU - White, David Y1 - 2010/02/01/ PY - 2010 DA - 2010 Feb 01 KW - Plastics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42272881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.atitle=Paper+or+Plastic%3F+Bringing+Resistance+Home&rft.au=White%2C+David&rft.aulast=White&rft.aufirst=David&rft.date=2010-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+Annual+Conference+on+Antimicrobial+Resistance&rft.issn=&rft_id=info:doi/ L2 - http://www.nfid.org/pdf/conferences/resistance10abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Considerations for Tissue-Engineered and Regenerative Medicine Product Development Prior to Clinical Trials in the United States AN - 21315593; 12537119 AB - Tissue-engineered and regenerative medicine products are promising innovative therapies that can address unmet clinical needs. These products are often combinations of cells, scaffolds, and other factors and are complex in both structure and function. Their complexity introduces challenges for product developers to establish novel manufacturing and characterization techniques to ensure that these products are safe and effective prior to clinical trials in humans. Although there are only a few commercial products that are currently in the market, many more tissue-engineered and regenerative medicine products are under development. Therefore, it is the purpose of this article to help product developers in the early stages of product development by providing insight into the Food and Drug Administration (FDA) process and by highlighting some of the key scientific considerations that may be applicable to their products. We provide resources that are publically available from the FDA and others that are of potential interest. As the provided information is general in content, product developers should contact the FDA for feedback regarding their specific products. Also described are ways through which product developers can informally and formally interact with the FDA early in the development process to help in the efficient progression of products toward clinical trials. JF - Tissue Engineering, Part B: Reviews AU - Lee, M H AU - Arcidiacono, JA AU - Bilek, A M AU - Wille, J J AU - Hamill, CA AU - Wonnacott, K M AU - Wells, MA AU - Oh, S S AD - Cellular Therapies Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Center for Biologies Evaluation and Research, United States Food and Drug Administration, 1401 Rockville Pike, HFM-715 Rockville, MD 20852, USA, mark.lee@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 41 EP - 54 VL - 16 IS - 1 SN - 1937-3368, 1937-3368 KW - Biotechnology and Bioengineering Abstracts KW - Structure-function relationships KW - Regeneration KW - Developmental stages KW - Feedback KW - Drug development KW - Tissue engineering KW - Clinical trials KW - scaffolds KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21315593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.atitle=Considerations+for+Tissue-Engineered+and+Regenerative+Medicine+Product+Development+Prior+to+Clinical+Trials+in+the+United+States&rft.au=Lee%2C+M+H%3BArcidiacono%2C+JA%3BBilek%2C+A+M%3BWille%2C+J+J%3BHamill%2C+CA%3BWonnacott%2C+K+M%3BWells%2C+MA%3BOh%2C+S+S&rft.aulast=Lee&rft.aufirst=M&rft.date=2010-02-01&rft.volume=16&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.issn=19373368&rft_id=info:doi/10.1089%2Ften.teb.2009.0449 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Structure-function relationships; Regeneration; Developmental stages; Drug development; Feedback; Tissue engineering; Clinical trials; scaffolds DO - http://dx.doi.org/10.1089/ten.teb.2009.0449 ER - TY - JOUR T1 - Use of Hydrogenophaga pseudoflava Penetration To Quantitatively Assess the Impact of Filtration Parameters for 0.2-Micrometer-Pore-Size Filters AN - 21294098; 11917363 AB - Filters rated as having a 0.2-km pore size (0.2-km-rated filters) are used in laboratory and manufacturing settings for diverse applications of bacterial and particle removal from process fluids, analytical test articles, and gasses. Using Hydrogenophaga pseudoflava, a diminutive bacterium with an unusual geometry (i.e., it is very thin), we evaluated passage through 0.2-km-rated filters and the impact of filtration process parameters and bacterial challenge density. We show that consistent H. pseudoflava passage occurs through 0.2-km-rated filters. This is in contrast to an absence of significant passage of nutritionally challenged bacteria that are of similar size (i.e., hydrodynamic diameter) but dissimilar geometry. JF - Applied and Environmental Microbiology AU - Lee, A AU - McVey, J AU - Faustino, P AU - Lute, S AU - Sweeney, N AU - Pawar, V AU - Khan, M AU - Brorson, K AU - Hussong, D AD - Office of Biotechnology Products, kurt.brorson@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 695 EP - 700 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 76 IS - 3 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Filters KW - Hydrogenophaga pseudoflava KW - A 01340:Antibiotics & Antimicrobials KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21294098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Use+of+Hydrogenophaga+pseudoflava+Penetration+To+Quantitatively+Assess+the+Impact+of+Filtration+Parameters+for+0.2-Micrometer-Pore-Size+Filters&rft.au=Lee%2C+A%3BMcVey%2C+J%3BFaustino%2C+P%3BLute%2C+S%3BSweeney%2C+N%3BPawar%2C+V%3BKhan%2C+M%3BBrorson%2C+K%3BHussong%2C+D&rft.aulast=Lee&rft.aufirst=A&rft.date=2010-02-01&rft.volume=76&rft.issue=3&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01825-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Number of references - 1 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Filters; Hydrogenophaga pseudoflava DO - http://dx.doi.org/10.1128/AEM.01825-09 ER - TY - JOUR T1 - Development of a personal dual-phase air sampling method for phthalate diesters AN - 21290612; 12536880 AB - Phthalates are used as plasticizers in many industrial and consumer products. Urinary biomonitoring has shown widespread human exposure to phthalates, with workers having especially high exposures. Phthalates can be present in workplace air as either aerosols or vapors depending on source materials, vapor pressure, and processing temperatures. We sought to develop a dual-phase air sampling method for 6 phthalates, dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BzBP), di(2-ethylhexyl) phthalate (DEHP), and di-n-octyl phthalate (DnOP), adaptable to aerosol inlets with known particle collection characteristics. Collection media consisted of a quartz fiber filter and XAD-2 resin. Limit of detection (LOD) and limit of quantification (LOQ) were determined for each phthalate. Phthalate recoveries were evaluated at 3x, lOx and 30x the LOQ, and after storage at --21 C and 21 C. Media were Soxhlet extracted in 10% diethyl ether in hexanes along with an extraction surrogate, di-n-pentyl phthalate-d sub(4). Gas chromatography/mass spectrometry was performed to quantify the phthalate diesters using di(2-ethylhexyl) phthalate-d sub(4) as an internal standard. Estimated LODs were 1 kg per sample (BzBP, DEHP, and DnOP), 2 kg per sample (DMP and DBP), and 5 kg per sample (DEP). Mean recoveries under static conditions were 85-104% for DBP, BzBP, DEHP, and DnOP; but <70% for DMP and DEP at 3x and 10x the LOQ. After air was pulled through spiked samples, DMP and DEP recoveries improved to 74-81%. After storage for 62 days, phthalate recovery was better at -21 C than at 21 C. Method accuracy was best for DBP, BzBP, DEHP, and DnOP (range 11-18%), and less so for DMP (28%) and DEP (29%). JF - Journal of Environmental Monitoring AU - Hines, C J AU - Yau, A Y AU - Zuniga, M M AU - Wells, J R AU - Hopf, NBN AU - Camann, DE AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4776 Columbia Pkwy, R-14, Cincinnati, OH, 45226, USA, chines@cdc.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 491 EP - 499 VL - 12 IS - 2 SN - 1464-0325, 1464-0325 KW - Health & Safety Science Abstracts; Environment Abstracts; Pollution Abstracts KW - Bioindicators KW - Aerosols KW - Resins KW - Consumer products KW - Temperature KW - Mass spectrometry KW - Particulates KW - Storage KW - Filters KW - vapor pressure KW - phthalates KW - Vapors KW - Urine KW - Gas chromatography KW - Phthalates KW - Air sampling KW - Ethers KW - Occupational exposure KW - Vapor pressure KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21290612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Monitoring&rft.atitle=Development+of+a+personal+dual-phase+air+sampling+method+for+phthalate+diesters&rft.au=Hines%2C+C+J%3BYau%2C+A+Y%3BZuniga%2C+M+M%3BWells%2C+J+R%3BHopf%2C+NBN%3BCamann%2C+DE&rft.aulast=Hines&rft.aufirst=C&rft.date=2010-02-01&rft.volume=12&rft.issue=2&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Monitoring&rft.issn=14640325&rft_id=info:doi/10.1039%2Fb913700a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-06-28 N1 - SubjectsTermNotLitGenreText - Bioindicators; Resins; Aerosols; Consumer products; Temperature; Mass spectrometry; Particulates; Filters; Storage; phthalates; vapor pressure; Vapors; Phthalates; Gas chromatography; Urine; Air sampling; Ethers; Vapor pressure; Occupational exposure DO - http://dx.doi.org/10.1039/b913700a ER - TY - JOUR T1 - RAPID RADIATION DOSE ASSESSMENT FOR RADIOLOGICAL PUBLIC HEALTH EMERGENCIES: ROLES OF NIAID AND BARDA AN - 21279777; 11851531 AB - A large-scale radiological incident would result in an immediate critical need to assess the radiation doses received by thousands of individuals to allow for prompt triage and appropriate medical treatment. Measuring absorbed doses of ionizing radiation will require a system architecture or a system of platforms that contains diverse, integrated diagnostic and dosimetric tools that are accurate and precise. For large-scale incidents, rapidity and ease of screening are essential. The National Institute of Allergy and Infectious Diseases of the National Institutes of Health is the focal point within the Department of Health and Human Services (HHS) for basic research and development of medical countermeasures for radiation injuries. The Biomedical Advanced Research and Development Authority within the HHS Office of the Assistant Secretary for Preparedness and Response coordinates and administers programs for the advanced development and acquisition of emergency medical countermeasures for the Strategic National Stockpile. Using a combination of funding mechanisms, including funds authorized by the Project BioShield Act of 2004 and those authorized by the Pandemic and All-Hazards Preparedness Act of 2006, HHS is enhancing the nation's preparedness by supporting the radiation dose assessment capabilities that will ensure effective and appropriate use of medical countermeasures in the aftermath of a radiological or nuclear incident. JF - Health Physics AU - Grace, M B AU - Moyer, B R AU - Prasher, J AU - Cliffer, K D AU - Ramakrishnan, N AU - Kaminski, J AU - Coleman, C N AU - Manning, R G AU - Maidment, B W AU - Hatchett, R AD - Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA, marcy.grace@hhs.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 172 EP - 178 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 98 IS - 2 SN - 0017-9078, 0017-9078 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Injuries KW - Allergies KW - Public health KW - Hypersensitivity KW - pandemics KW - Infectious diseases KW - Dose-response effects KW - Ionizing radiation KW - Medical treatment KW - Research programs KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=RAPID+RADIATION+DOSE+ASSESSMENT+FOR+RADIOLOGICAL+PUBLIC+HEALTH+EMERGENCIES%3A+ROLES+OF+NIAID+AND+BARDA&rft.au=Grace%2C+M+B%3BMoyer%2C+B+R%3BPrasher%2C+J%3BCliffer%2C+K+D%3BRamakrishnan%2C+N%3BKaminski%2C+J%3BColeman%2C+C+N%3BManning%2C+R+G%3BMaidment%2C+B+W%3BHatchett%2C+R&rft.aulast=Grace&rft.aufirst=M&rft.date=2010-02-01&rft.volume=98&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2F01.HP.0000348001.60905.c0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2013-08-12 N1 - SubjectsTermNotLitGenreText - pandemics; Hypersensitivity; Infectious diseases; Injuries; Ionizing radiation; Public health; Dose-response effects; Medical treatment; Allergies; Research programs DO - http://dx.doi.org/10.1097/01.HP.0000348001.60905.c0 ER - TY - JOUR T1 - Naturally occurring propionic acid in foods marketed in South Korea AN - 21082981; 11088903 AB - Propionic acid levels in fermented products, non-fermented products and foodstuffs, and medicinal herbs were analyzed total 263 samples retailed in Korean market. Propionic acid was detected in some Korean traditional fermented products such as salted and fermented fish sauce, Chunggukjang and salted and fermented fish. A small amount of propionic acid was also detected in fermented soybean paste, soy sauce, seasoned soybean paste, vinegar and fermented milk. Significantly, propionic acid in vinegar showed high levels among fermented products (P<0.05). Among non-fermented products and foodstuffs, propionic acid in shellfish showed high level, while propionic acid was not detected in cereal and sauce. A statistically significant difference was shown in propionic acid levels of shellfish. propionic acid in brackish water clam showed significantly higher levels than that of others. Ark shell and scallop also showed high levels in propionic acid. Among 10 kinds of medicinal herbs, propionic acid was detected in 3 samples (Lycium chinensis Miller, Astragali radix and Atractylodes rhizoma). JF - Food Control AU - Lee, Hwa-Jung AU - Ahn, Hyun-Joo AU - Kang, Chan-Soon AU - Choi, Jae-Chun AU - Choi, Hee-Ju AU - Lee, Kwang-Geun AU - Kim, Jae-In AU - Kim, Hee-Yun AD - Testing and Analysis Division, Seoul Regional Korea Food and Drug Administration, 900-12 Mok-dong, Yangcheon-gu, Seoul 158-050, South Korea, hjahn@kfda.go.kr Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 217 EP - 220 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 21 IS - 2 SN - 0956-7135, 0956-7135 KW - Biotechnology and Bioengineering Abstracts KW - Propionic acid KW - Fermentation KW - Korean traditional fermented foods KW - Medicinal herb KW - Lycium KW - Milk KW - Vinegar KW - Food KW - Statistical analysis KW - Soybeans KW - Cereals KW - Herbal medicines KW - Brackish water KW - Sauces KW - Shells KW - Soy sauce KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21082981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Control&rft.atitle=Naturally+occurring+propionic+acid+in+foods+marketed+in+South+Korea&rft.au=Lee%2C+Hwa-Jung%3BAhn%2C+Hyun-Joo%3BKang%2C+Chan-Soon%3BChoi%2C+Jae-Chun%3BChoi%2C+Hee-Ju%3BLee%2C+Kwang-Geun%3BKim%2C+Jae-In%3BKim%2C+Hee-Yun&rft.aulast=Lee&rft.aufirst=Hwa-Jung&rft.date=2010-02-01&rft.volume=21&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Food+Control&rft.issn=09567135&rft_id=info:doi/10.1016%2Fj.foodcont.2009.04.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Milk; Cereals; Vinegar; Food; Statistical analysis; Herbal medicines; Propionic acid; Brackish water; Sauces; Soy sauce; Shells; Soybeans; Lycium DO - http://dx.doi.org/10.1016/j.foodcont.2009.04.006 ER - TY - JOUR T1 - Biennial hyperepidemic shigellosis in an observant Jewish community AN - 205508150; 19602299 AB - SUMMARY We aimed to study patterns of shigellosis in a large observant Jewish community in Israel and to describe local interventions during outbreaks. Surveillance data from the Ministry of Health were used to calculate incidence rates in 1998-2006, both in the city of Bene Beraq and the Tel Aviv district. Information on isolates was collected from the bacteriological laboratory of a community hospital. Public notices and educational conferences conveyed a message to increase personal hygiene and keep ill children at home. During a 9-year period, a clear biennial pattern of outbreaks was noticed. Annual incidence rates ranged between 18 and 353/100 000 population. Shigellosis outbreaks tended to occur in the winter and were attributed to clonally related Shigella sonnei strains. Outbreaks in Bene Beraq preceded those in the other cities of Tel Aviv district, suggesting propagation of disease. In this population with highly endemic as well as superimposed outbreaks of shigellosis, short-term interventions had no lasting effect on prevention; future studies should focus on community-based programmes to avoid anticipated outbreaks. [PUBLICATION ABSTRACT] JF - Epidemiology and Infection AU - CALDERON-MARGALIT, R AU - NAVON-VENEZIA, S AU - GEFEN, D AU - AMITAI, Z AU - BARDA, R AU - VULIKH, I AU - SOMPOLINSKY, D Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 244 EP - 52 CY - Cambridge PB - Cambridge University Press VL - 138 IS - 2 SN - 09502688 KW - Physical Fitness And Hygiene KW - Israel -- epidemiology KW - Humans KW - Shigella sonnei -- genetics KW - Aged, 80 & over KW - Child KW - Child, Preschool KW - Infant KW - Community-Acquired Infections -- epidemiology KW - Seasons KW - Adult KW - Electrophoresis, Gel, Pulsed-Field KW - Incidence KW - Judaism KW - Adolescent KW - Male KW - Female KW - Shigella sonnei -- isolation & purification KW - Dysentery, Bacillary -- epidemiology KW - Disease Outbreaks -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/205508150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Biennial+hyperepidemic+shigellosis+in+an+observant+Jewish+community&rft.au=CALDERON-MARGALIT%2C+R%3BNAVON-VENEZIA%2C+S%3BGEFEN%2C+D%3BAMITAI%2C+Z%3BBARDA%2C+R%3BVULIKH%2C+I%3BSOMPOLINSKY%2C+D&rft.aulast=CALDERON-MARGALIT&rft.aufirst=R&rft.date=2010-02-01&rft.volume=138&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268809990379 LA - English DB - ProQuest Central N1 - Copyright - Copyright © Cambridge University Press 2009 N1 - Last updated - 2015-08-15 DO - http://dx.doi.org/10.1017/S0950268809990379 ER - TY - JOUR T1 - Ginkgo Biloba Extract Induces Gene Expression Changes in Xenobiotics Metabolism and the Myc-Centered Network AN - 1367484053; 17891942 AB - The use of herbal dietary supplements in the United States is rapidly growing, and it is crucial that the quality and safety of these preparations be ensured. To date, it is still a challenge to determine the mechanisms of toxicity induced by mixtures containing many chemical components, such as herbal dietary supplements. We previously proposed that analyses of the gene expression profiles using microarrays in the livers of rodents treated with herbal dietary supplements is a potentially practical approach for understanding the mechanism of toxicity. In this study, we utilized microarrays to analyze gene expression changes in the livers of male B6C3F1 mice administered Ginkgo biloba leaf extract (GBE) by gavage for 2 years, and to determine pathways and mechanisms associated with GBE treatments. Analysis of 31,802 genes revealed that there were 129, 289, and 2,011 genes significantly changed in the 200, 600, and 2,000mg/kg treatment groups, respectively, when compared with control animals. Drug metabolizing genes were significantly altered in response to GBE treatments. Pathway and network analyses were applied to investigate the gene relationships, functional clustering, and mechanisms involved in GBE exposure. These analyses indicate alteration in the expression of genes coding for drug metabolizing enzymes, the NRF2-mediated oxidative stress response pathway, and the Myc gene-centered network named "cell cycle, cellular movement, and cancer" were found. These results indicate that Ginkgo biloba-related drug metabolizing enzymes may cause herb-drug interactions and contribute to hepatotoxicity. In addition, the outcomes of pathway and network analysis may be used to elucidate the toxic mechanisms of Ginkgo biloba. JF - OMICS: A Journal of Integrative Biology AU - Guo, L AU - Mei, N AU - Llao, W AU - Chan, P-C AU - Fu, P P AD - Division of Systems Toxicology, National Center For Toxicological Research, FDA, Jefferson, AR 72079, USA, lei.guo@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - Feb 2010 SP - 75 EP - 90 VL - 14 IS - 1 SN - 1536-2310, 1536-2310 KW - Toxicology Abstracts; Genetics Abstracts KW - Cell cycle KW - Leaves KW - Enzymes KW - Toxicity KW - Xenobiotics KW - DNA microarrays KW - Cancer KW - hepatotoxicity KW - Gene expression KW - Myc protein KW - Ginkgo biloba KW - Oxidative stress KW - Dietary supplements KW - Liver KW - Cell migration KW - Drugs KW - Metabolism KW - X 24320:Food Additives & Contaminants KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1367484053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=OMICS%3A+A+Journal+of+Integrative+Biology&rft.atitle=Ginkgo+Biloba+Extract+Induces+Gene+Expression+Changes+in+Xenobiotics+Metabolism+and+the+Myc-Centered+Network&rft.au=Guo%2C+L%3BMei%2C+N%3BLlao%2C+W%3BChan%2C+P-C%3BFu%2C+P+P&rft.aulast=Guo&rft.aufirst=L&rft.date=2010-02-01&rft.volume=14&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=OMICS%3A+A+Journal+of+Integrative+Biology&rft.issn=15362310&rft_id=info:doi/10.1089%2Fomi.2009.0115 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-06-01 N1 - Last updated - 2013-08-23 N1 - SubjectsTermNotLitGenreText - Cell cycle; Leaves; Enzymes; Xenobiotics; Toxicity; DNA microarrays; hepatotoxicity; Cancer; Myc protein; Gene expression; Oxidative stress; Dietary supplements; Liver; Cell migration; Drugs; Metabolism; Ginkgo biloba DO - http://dx.doi.org/10.1089/omi.2009.0115 ER - TY - JOUR T1 - Changes in US antidepressant and antipsychotic prescription patterns during a period of FDA actions AN - 1257744558; 16701165 AB - Purpose To determine if paroxetine versus non-paroxetine selective serotonin reuptake inhibitors (SSRIs) prescribing changed after the June 2003 FDA Paroxetine Public Health Advisory (PPHA) and if antidepressant and antipsychotic prescribing changed after the February 2004 FDA Advisory Committee Meeting (FDACM). Methods Ecologic analysis using estimates of patients dispensed antidepressants and antipsychotics, census data, and promotional spending data. Data sources were SDI: Vector One?, US Census, and IMS Health?. Measures were monthly use levels (number of patients dispensed antidepressants, antipsychotics, paroxetine, and non-paroxetine SSRIs prescriptions by age group per population count). Percent changes pre- to post-PPHA were used to assess changes in paroxetine versus non-paroxetine SSRIs prescribing. Interrupted time series (ITS) analysis was performed to examine use level changes post-FDACM by drug groups (all antidepressants and all antipsychotics). Results Post-PPHA mean paroxetine use levels decreased for all age groups (range: 5.5-34.1%). Mean non-paroxetine SSRIs use levels increased (range: 4.6-17.1%). Post-PPHA changes were greatest for 6-12 and 13-17 year olds. Decreased mean antidepressant drug use levels from pre- to post-FDACM were observed in all groups under 25 years old. A statistically significant decrease in the slopes from pre- to post-FDACM was observed for persons aged 13-17 and 18-24 years. The difference between the forecasted mean use level and the observed mean use level (in 12-month intervals) was statistically significant for all ages combined (-107.26; 95% CI: -166.32, -48.20) and 1-5 (-3.1; 95% CI: -4.62, -1.58), 6-12 (-36.02; 95% CI: -62.92, -9.12) and 25 years, and older groups (-83.17; 95% CI: -153.95, -12.39). For all age groups, decreases in the slopes of antipsychotic drugs use from pre- to post-FDACM were observed, although these slope changes were not statistically significant. The difference between the forecasted mean antipsychotic drugs use level and the observed mean use level (in 12-month intervals) was statistically significantly lower for all age groups. Conclusions Antidepressant use changed post-PPHA and -FDACM, with a differential pattern by age. There was no evidence of increased antipsychotic use post-FDACM. Ecologic data cannot determine if changes were due to depression not treated with medications or the prescribing of fewer antidepressants for other conditions. Published in 2009 by John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and Drug Safety AU - Pamer, Carol A AU - Hammad, Tarek A AU - Wu, Yu-te AU - Kaplan, Sigal AU - Rochester, George AU - Governale, Laura AU - Mosholder, Andrew D AD - FDA Office of Surveillance and Epidemiology, Silver Spring, MD, United States, carol.pamer@fda.hhs.gov Y1 - 2010/02// PY - 2010 DA - February 2010 SP - 158 EP - 174 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 19 IS - 2 SN - 1099-1557, 1099-1557 KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Age KW - Data processing KW - Statistical analysis KW - Serotonin uptake inhibitors KW - Drug abuse KW - paroxetine KW - Public health KW - Antidepressants KW - USA KW - Neuroleptics KW - FDA KW - Age groups KW - Census KW - Drugs KW - Long-term depression KW - N3 11028:Neuropharmacology & toxicology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1257744558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Changes+in+US+antidepressant+and+antipsychotic+prescription+patterns+during+a+period+of+FDA+actions&rft.au=Pamer%2C+Carol+A%3BHammad%2C+Tarek+A%3BWu%2C+Yu-te%3BKaplan%2C+Sigal%3BRochester%2C+George%3BGovernale%2C+Laura%3BMosholder%2C+Andrew+D&rft.aulast=Pamer&rft.aufirst=Carol&rft.date=2010-02-01&rft.volume=19&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10991557&rft_id=info:doi/10.1002%2Fpds.1886 L2 - http://onlinelibrary.wiley.com/doi/10.1002/pds.1886/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-12-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Antidepressants; Age; Data processing; Neuroleptics; Statistical analysis; Serotonin uptake inhibitors; Census; Long-term depression; Drugs; paroxetine; Public health; FDA; Age groups; Drug abuse; USA DO - http://dx.doi.org/10.1002/pds.1886 ER - TY - JOUR T1 - Striatal dopamine in the response of brain and liver unsaturated and saturated free fatty acids following administration of C75 in CD-1 mice. AN - 733869377; 20026180 AB - In order to clarify the mechanism of action of cerulenin analog, C75, known to suppress feeding behavior, food intake was measured in adult CD-1 male mice n=5 per group, treated i.p. with 10 and 20mg/kg of C75. Animals in both treatment groups had significantly lower 24h food consumption rate relative to the control group injected with vehicle. Striatal monoamine neurotransmitters and striatal as well as liver long chain free fatty acids concentrations were subsequently evaluated in another group treated i.p. with 20mg/kg C75. Acute exposure to C75 at 20mg/kg led to approximately 50% increase in the striatal dopamine levels and a decrease in dopamine turnover for up to 24h following the injection. The concentration of serotonin remained unchanged. Concentration of saturated fatty acids in the liver and striatum did not change, while striatal unsaturated myristoleic acid (cis-9-tetradecenoic acid) levels were significantly higher as early as 2h post-injection and remained elevated at 24h post-injection. These preliminary data suggest a central regulatory role of unsaturated fatty acids under dopaminergic control in the C75-induced anorexia. Pharmacological alterations in fatty acid metabolism may prove beneficial in the treatment of obesity. (c) 2009 Elsevier Ireland Ltd. All rights reserved. JF - Neuroscience letters AU - Binienda, Z K AU - Ross, I A AU - Gough, B AU - Riccio, T AU - Kim, C S AU - Ali, S F AD - Division of Neurotoxicology, NCTR/FDA, Jefferson, AR 72079, USA. zbigniew.binienda@fda.hhs.gov Y1 - 2010/01/29/ PY - 2010 DA - 2010 Jan 29 SP - 324 EP - 327 VL - 469 IS - 3 KW - Anti-Obesity Agents KW - 0 KW - Biogenic Monoamines KW - Fatty Acids, Monounsaturated KW - Fatty Acids, Nonesterified KW - Fatty Acids, Unsaturated KW - Neurotransmitter Agents KW - Cerulenin KW - 17397-89-6 KW - Serotonin KW - 333DO1RDJY KW - 9-tetradecenoic acid KW - 544-64-9 KW - alpha-methylene gamma-butyrolactone KW - 547-65-9 KW - 4-Butyrolactone KW - OL659KIY4X KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Eating -- drug effects KW - Animals KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Brain -- metabolism KW - Mice KW - Biogenic Monoamines -- metabolism KW - Mice, Inbred Strains KW - Neurotransmitter Agents -- metabolism KW - Serotonin -- metabolism KW - Fatty Acids, Monounsaturated -- metabolism KW - Time Factors KW - Cerulenin -- analogs & derivatives KW - Male KW - Anti-Obesity Agents -- administration & dosage KW - Fatty Acids, Unsaturated -- metabolism KW - 4-Butyrolactone -- administration & dosage KW - Corpus Striatum -- metabolism KW - Anti-Obesity Agents -- pharmacology KW - Liver -- metabolism KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - 4-Butyrolactone -- pharmacology KW - Fatty Acids, Nonesterified -- metabolism KW - 4-Butyrolactone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733869377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Striatal+dopamine+in+the+response+of+brain+and+liver+unsaturated+and+saturated+free+fatty+acids+following+administration+of+C75+in+CD-1+mice.&rft.au=Binienda%2C+Z+K%3BRoss%2C+I+A%3BGough%2C+B%3BRiccio%2C+T%3BKim%2C+C+S%3BAli%2C+S+F&rft.aulast=Binienda&rft.aufirst=Z&rft.date=2010-01-29&rft.volume=469&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2009.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-04-12 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.neulet.2009.12.019 ER - TY - CPAPER T1 - Enhancement of HCV Cell Culture by Evading Interferon T2 - 8th Cytokines & Inflammation Conference AN - 42367243; 5666270 JF - 8th Cytokines & Inflammation Conference AU - Taylor, Deborah Y1 - 2010/01/28/ PY - 2010 DA - 2010 Jan 28 KW - Cell culture KW - Interferon KW - Hepatitis C virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42367243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=8th+Cytokines+%26+Inflammation+Conference&rft.atitle=Enhancement+of+HCV+Cell+Culture+by+Evading+Interferon&rft.au=Taylor%2C+Deborah&rft.aulast=Taylor&rft.aufirst=Deborah&rft.date=2010-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=8th+Cytokines+%26+Inflammation+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/conferenceDetails.aspx?id=171 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Aggregates and Foreign Particles: Characterization and Impact on Product Safety T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42371126; 5667102 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Cordoba-Rodriguez, Ruth AU - Li, Gary AU - Marszal, Ewa Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Particulates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42371126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Protein+Aggregates+and+Foreign+Particles%3A+Characterization+and+Impact+on+Product+Safety&rft.au=Cordoba-Rodriguez%2C+Ruth%3BLi%2C+Gary%3BMarszal%2C+Ewa&rft.aulast=Cordoba-Rodriguez&rft.aufirst=Ruth&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - QbD for Analytics T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42369988; 5667127 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Gupta, Rajesh AU - Moore, Christine AU - Schmalzing, Dieter Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42369988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=QbD+for+Analytics&rft.au=Gupta%2C+Rajesh%3BMoore%2C+Christine%3BSchmalzing%2C+Dieter&rft.aulast=Gupta&rft.aufirst=Rajesh&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparability of Biotechnology-Derived Protein Products: Lessons from the U.S Experience T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42369676; 5667110 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Cherney, Barry Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - USA KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42369676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Comparability+of+Biotechnology-Derived+Protein+Products%3A+Lessons+from+the+U.S+Experience&rft.au=Cherney%2C+Barry&rft.aulast=Cherney&rft.aufirst=Barry&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Proteins From Transgenic Animal Bioreactors: Present and Future T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42368119; 5667115 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Drews, Roman AU - Meade, Harry AU - Pluznik, Dov AU - Ziomek, Carol Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Bioreactors KW - Transgenic animals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42368119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Therapeutic+Proteins+From+Transgenic+Animal+Bioreactors%3A+Present+and+Future&rft.au=Drews%2C+Roman%3BMeade%2C+Harry%3BPluznik%2C+Dov%3BZiomek%2C+Carol&rft.aulast=Drews&rft.aufirst=Roman&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Critical Quality Attributes for Biotechnology Products: A Regulatory Perspective T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42367813; 5667099 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Swann, Patrick Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Biotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42367813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Critical+Quality+Attributes+for+Biotechnology+Products%3A+A+Regulatory+Perspective&rft.au=Swann%2C+Patrick&rft.aulast=Swann&rft.aufirst=Patrick&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trading Spaces: Risks and Mitigations for Assay Transfer T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42367483; 5667122 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Anderson, Howard AU - Gupta, Rajesh AU - Kutza, Joseph AU - Schofield, Timothy Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Mitigation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42367483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Trading+Spaces%3A+Risks+and+Mitigations+for+Assay+Transfer&rft.au=Anderson%2C+Howard%3BGupta%2C+Rajesh%3BKutza%2C+Joseph%3BSchofield%2C+Timothy&rft.aulast=Anderson&rft.aufirst=Howard&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges in Regulation of Biopharmaceuticals T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42366419; 5667092 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Woodcock, Janet Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Pharmaceuticals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42366419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Challenges+in+Regulation+of+Biopharmaceuticals&rft.au=Woodcock%2C+Janet&rft.aulast=Woodcock&rft.aufirst=Janet&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Center for Biologics Evaluation and Research: Update on Current Activities and Future Directions T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42365493; 5667093 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Midthun, Karen Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42365493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Center+for+Biologics+Evaluation+and+Research%3A+Update+on+Current+Activities+and+Future+Directions&rft.au=Midthun%2C+Karen&rft.aulast=Midthun&rft.aufirst=Karen&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMR of Polysaccharide Antigens on Living Cells T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42365321; 5667119 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Freedberg, Daron Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - N.M.R. KW - Polysaccharides KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42365321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=NMR+of+Polysaccharide+Antigens+on+Living+Cells&rft.au=Freedberg%2C+Daron&rft.aulast=Freedberg&rft.aufirst=Daron&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ignorance Is Not Bliss: Designing a Pragmatic Product Characterization Strategy T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42365029; 5667126 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Moos, Malcolm AU - Pedras-Vasconcelos, Joao AU - Seaver, Sally Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42365029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Ignorance+Is+Not+Bliss%3A+Designing+a+Pragmatic+Product+Characterization+Strategy&rft.au=Moos%2C+Malcolm%3BPedras-Vasconcelos%2C+Joao%3BSeaver%2C+Sally&rft.aulast=Moos&rft.aufirst=Malcolm&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quality by Design for Biotechnology Products: Facilitating Implementation T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42364243; 5667130 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Kozlowski, Steven Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Biotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42364243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Quality+by+Design+for+Biotechnology+Products%3A+Facilitating+Implementation&rft.au=Kozlowski%2C+Steven&rft.aulast=Kozlowski&rft.aufirst=Steven&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Controversies in Protein Stability T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42364213; 5667128 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Graham, Laurie AU - Krause, Philip AU - Ma, Stacey Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42364213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Controversies+in+Protein+Stability&rft.au=Graham%2C+Laurie%3BKrause%2C+Philip%3BMa%2C+Stacey&rft.aulast=Graham&rft.aufirst=Laurie&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Addressing Pandemic Influenza Vaccine Preparedness T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42364184; 5667116 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Hu-Primmer, Jean Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Vaccines KW - Influenza KW - Pandemics KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42364184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Addressing+Pandemic+Influenza+Vaccine+Preparedness&rft.au=Hu-Primmer%2C+Jean&rft.aulast=Hu-Primmer&rft.aufirst=Jean&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hot Topics in Comparability T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42364151; 5667114 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Farshid, Mahmood AU - Kennett, Sarah AU - Van Auwelaer, Carol Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42364151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Hot+Topics+in+Comparability&rft.au=Farshid%2C+Mahmood%3BKennett%2C+Sarah%3BVan+Auwelaer%2C+Carol&rft.aulast=Farshid&rft.aufirst=Mahmood&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Future of Process Validation T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42363961; 5667103 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Fuchs, Chana AU - Nunnally, Brian AU - Syin, Chiang Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42363961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=The+Future+of+Process+Validation&rft.au=Fuchs%2C+Chana%3BNunnally%2C+Brian%3BSyin%2C+Chiang&rft.aulast=Fuchs&rft.aufirst=Chana&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Novel Analytical Technologies in Biotechnology Product Development T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42363497; 5667124 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Freedberg, Daron AU - Ledwidge, Richard AU - Russell, Reb Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Biotechnology KW - Technology KW - Product development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42363497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=The+Role+of+Novel+Analytical+Technologies+in+Biotechnology+Product+Development&rft.au=Freedberg%2C+Daron%3BLedwidge%2C+Richard%3BRussell%2C+Reb&rft.aulast=Freedberg&rft.aufirst=Daron&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fortune Favors the Prepared - Managing the Risks of Bacterial, Viral and Other Contaminants T2 - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AN - 42362859; 5667123 JF - 14th Symposium on the Interface of Regulatory and Analytical Sciences for Biotechnology Health Products (WCBP 2010) AU - Bernstein, Ralph AU - Garnick, Robert AU - Mattaliano, Robert AU - Sillivan, Destry Y1 - 2010/01/24/ PY - 2010 DA - 2010 Jan 24 KW - Contaminants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42362859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.atitle=Fortune+Favors+the+Prepared+-+Managing+the+Risks+of+Bacterial%2C+Viral+and+Other+Contaminants&rft.au=Bernstein%2C+Ralph%3BGarnick%2C+Robert%3BMattaliano%2C+Robert%3BSillivan%2C+Destry&rft.aulast=Bernstein&rft.aufirst=Ralph&rft.date=2010-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Symposium+on+the+Interface+of+Regulatory+and+Analytical+Sciences+for+Biotechnology+Health+Products+%28WCBP+2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.casss.org/associations/9165/files/WCBP2010ScientificProgram .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppression of Modal Noise in a Multimode Fiber-Optic Delivery Output from an Ultra-Broadband Supercontinuum Light Source T2 - 2010 SPIE Photonics West AN - 754161968; 5716561 JF - 2010 SPIE Photonics West AU - Kim, Do-Hyun AU - Ilev, Ilko AU - Klein, Karl-Friedrich Y1 - 2010/01/23/ PY - 2010 DA - 2010 Jan 23 KW - Light sources KW - Noise levels KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754161968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SPIE+Photonics+West&rft.atitle=Suppression+of+Modal+Noise+in+a+Multimode+Fiber-Optic+Delivery+Output+from+an+Ultra-Broadband+Supercontinuum+Light+Source&rft.au=Kim%2C+Do-Hyun%3BIlev%2C+Ilko%3BKlein%2C+Karl-Friedrich&rft.aulast=Kim&rft.aufirst=Do-Hyun&rft.date=2010-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SPIE+Photonics+West&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2010-Advance-Progra LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Novel applications of diagnostic x-rays in activating photoagents through x-ray induced visible fluorescence from rare-earth particles: an in-vitro study T2 - 2010 SPIE Photonics West AN - 754161153; 5716849 JF - 2010 SPIE Photonics West AU - Tata, Darrell AU - Waynant, Ronald AU - Collins, Joshua AU - Friedberg, Joseph AU - Kumar, Ajith AU - Bell, Howard Y1 - 2010/01/23/ PY - 2010 DA - 2010 Jan 23 KW - Particulates KW - Fluorescence KW - Ionizing radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754161153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SPIE+Photonics+West&rft.atitle=Novel+applications+of+diagnostic+x-rays+in+activating+photoagents+through+x-ray+induced+visible+fluorescence+from+rare-earth+particles%3A+an+in-vitro+study&rft.au=Tata%2C+Darrell%3BWaynant%2C+Ronald%3BCollins%2C+Joshua%3BFriedberg%2C+Joseph%3BKumar%2C+Ajith%3BBell%2C+Howard&rft.aulast=Tata&rft.aufirst=Darrell&rft.date=2010-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SPIE+Photonics+West&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2010-Advance-Progra LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - In vitro suppression of metabolic activity in malignant human brain cancer and normal human fibroblast due to extremely low frequency pulsed electric potential exposures T2 - 2010 SPIE Photonics West AN - 754155295; 5716201 JF - 2010 SPIE Photonics West AU - Tata, Darrell AU - Schlichting, Abby AU - Waynant, Ronald Y1 - 2010/01/23/ PY - 2010 DA - 2010 Jan 23 KW - Cancer KW - Fibroblasts KW - Electric potential KW - Low frequency KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754155295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SPIE+Photonics+West&rft.atitle=In+vitro+suppression+of+metabolic+activity+in+malignant+human+brain+cancer+and+normal+human+fibroblast+due+to+extremely+low+frequency+pulsed+electric+potential+exposures&rft.au=Tata%2C+Darrell%3BSchlichting%2C+Abby%3BWaynant%2C+Ronald&rft.aulast=Tata&rft.aufirst=Darrell&rft.date=2010-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SPIE+Photonics+West&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2010-Advance-Progra LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - In situ optical property measurement in layered tissue: theoretical and experimental assessment of an unconstrained approach T2 - 2010 SPIE Photonics West AN - 754154987; 5716441 JF - 2010 SPIE Photonics West AU - Wang, Quanzeng AU - Shastri, Karthik AU - Agrawal, Anant AU - Pfefer, Joshua Y1 - 2010/01/23/ PY - 2010 DA - 2010 Jan 23 KW - Optical properties KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754154987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+SPIE+Photonics+West&rft.atitle=In+situ+optical+property+measurement+in+layered+tissue%3A+theoretical+and+experimental+assessment+of+an+unconstrained+approach&rft.au=Wang%2C+Quanzeng%3BShastri%2C+Karthik%3BAgrawal%2C+Anant%3BPfefer%2C+Joshua&rft.aulast=Wang&rft.aufirst=Quanzeng&rft.date=2010-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+SPIE+Photonics+West&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/Documents/ConferencesExhibitions/PW2010-Advance-Progra LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-02 N1 - Last updated - 2010-09-25 ER - TY - CPAPER T1 - Screening Foods for Unknown Chemical Contaminants by Non-Targeted LC/MS Analysis T2 - 2010 International Conference on Lab Automation (LabAutomation2010) AN - 42355551; 5657105 JF - 2010 International Conference on Lab Automation (LabAutomation2010) AU - Musser, Steve Y1 - 2010/01/23/ PY - 2010 DA - 2010 Jan 23 KW - Chemical pollution KW - Contaminants KW - Food KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42355551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2010+International+Conference+on+Lab+Automation+%28LabAutomation2010%29&rft.atitle=Screening+Foods+for+Unknown+Chemical+Contaminants+by+Non-Targeted+LC%2FMS+Analysis&rft.au=Musser%2C+Steve&rft.aulast=Musser&rft.aufirst=Steve&rft.date=2010-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2010+International+Conference+on+Lab+Automation+%28LabAutomation2010%29&rft.issn=&rft_id=info:doi/ L2 - http://www.labautomation.org/LA10/ALA_LA2010_FinalProgram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion. AN - 734175487; 19913272 AB - The flaviviral envelope (E) protein directs virus-mediated membrane fusion. To investigate membrane fusion as a requirement for virus growth, we introduced 27 unique mutations into the fusion peptide of an infectious cDNA clone of dengue 2 virus and recovered seven stable mutant viruses. The fusion efficiency of the mutants was impaired, demonstrating for the first time the requirement for specific FP AAs in optimal fusion. Mutant viruses exhibited different growth kinetics and/or genetic stabilities in different cell types and adult mosquitoes. Virus particles could be recovered following RNA transfection of cells with four lethal mutants; however, recovered viruses could not re-infect cells. These viruses could enter cells, but internalized virus appeared to be retained in endosomal compartments of infected cells, thus suggesting a fusion blockade. Mutations of the FP also resulted in reduced virus reactivity with flavivirus group-reactive antibodies, confirming earlier reports using virus-like particles. JF - Virology AU - Huang, Claire Y-H AU - Butrapet, Siritorn AU - Moss, Kelly J AU - Childers, Thomas AU - Erb, Steven M AU - Calvert, Amanda E AU - Silengo, Shawn J AU - Kinney, Richard M AU - Blair, Carol D AU - Roehrig, John T AD - Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, 3150 Rampart Rd., Fort Collins, CO 80521, USA. CHuang1@cdc.gov Y1 - 2010/01/20/ PY - 2010 DA - 2010 Jan 20 SP - 305 EP - 315 VL - 396 IS - 2 KW - Antigens, Viral KW - 0 KW - Viral Fusion Proteins KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Dengue -- virology KW - Animals KW - Virus Replication -- genetics KW - Transfection KW - Aedes -- virology KW - Antigens, Viral -- immunology KW - Cercopithecus aethiops KW - Vero Cells KW - Virus Replication -- physiology KW - Female KW - Cell Line KW - Membrane Fusion -- physiology KW - Viral Fusion Proteins -- physiology KW - Viral Fusion Proteins -- genetics KW - Dengue Virus -- genetics KW - Dengue Virus -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734175487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+dengue+virus+type+2+envelope+protein+fusion+peptide+is+essential+for+membrane+fusion.&rft.au=Huang%2C+Claire+Y-H%3BButrapet%2C+Siritorn%3BMoss%2C+Kelly+J%3BChilders%2C+Thomas%3BErb%2C+Steven+M%3BCalvert%2C+Amanda+E%3BSilengo%2C+Shawn+J%3BKinney%2C+Richard+M%3BBlair%2C+Carol+D%3BRoehrig%2C+John+T&rft.aulast=Huang&rft.aufirst=Claire&rft.date=2010-01-20&rft.volume=396&rft.issue=2&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.10.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-05 N1 - Date created - 2009-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.10.027 ER - TY - JOUR T1 - Toxicological Consequences of Extracellular Hemoglobin: Biochemical and Physiological Perspectives AN - 21305460; 11911559 AB - Under normal physiology, human red blood cells (RBCs) demonstrate a circulating lifespan of 6100-120 days with efficient removal of senescent RBCs taking place via the reticuloendothelial system, spleen, and bone marrow phagocytosis. Within this time frame, hemoglobin (Hb) is effectively protected by efficient RBC enzymatic systems designed to allow for interaction between Hb and diffusible ligands while preventing direct contact between Hb and the external environment. Under normal resting conditions, the concentration of extracellular Hb in circulation is therefore minimal and controlled by specific plasma and cellular (monocyte/macrophage) binding proteins (haptoglobin) and receptors (CD163), respectively. However, during pathological conditions leading to hemolysis, extracellular Hb concentrations exceed normal plasma and cellular binding capacities, allowing Hb to become a biologically relevant vasoactive and redox active protein within the circulation and at extravascular sites. Under conditions of genetic, drug-induced, and autoimmune hemolytic anemias, large quantities of Hb are introduced into the circulation and often lead to acute renal failure and vascular dysfunction. Interestingly, the study of chemically modified Hb for use as oxygen therapeutics has allowed for some basic understanding of extracellular Hb toxicity, particularly in the absence of functional clearance mechanisms and in circulatory anti-oxidant depleted states. JF - Antioxidants and Redox Signaling AU - Buehler, P W AU - D'Agnillo, F AD - Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health (NIH) Campus, 8800 Rockville Pike, Bldg. 29, Rm. 129, Bethesda, MD 20892, USA, paul.buehler@fda.hhs.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 275 EP - 291 VL - 12 IS - 2 SN - 1523-0864, 1523-0864 KW - Toxicology Abstracts KW - Macrophages KW - Autoimmune hemolytic anemia KW - Antioxidants KW - Life span KW - Erythrocytes KW - Bone marrow KW - CD163 antigen KW - Spleen KW - Renal failure KW - Toxicity KW - Reticuloendothelial system KW - Vasoactive agents KW - Hemoglobin KW - Oxygen KW - Haptoglobin KW - Hemolysis KW - Monocytes KW - Phagocytosis KW - Signal transduction KW - Vascular system KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21305460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+and+Redox+Signaling&rft.atitle=Toxicological+Consequences+of+Extracellular+Hemoglobin%3A+Biochemical+and+Physiological+Perspectives&rft.au=Buehler%2C+P+W%3BD%27Agnillo%2C+F&rft.aulast=Buehler&rft.aufirst=P&rft.date=2010-01-15&rft.volume=12&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Antioxidants+and+Redox+Signaling&rft.issn=15230864&rft_id=info:doi/10.1089%2Fars.2009.2799 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Macrophages; Autoimmune hemolytic anemia; Antioxidants; Erythrocytes; Life span; CD163 antigen; Bone marrow; Renal failure; Spleen; Toxicity; Reticuloendothelial system; Vasoactive agents; Hemoglobin; Oxygen; Haptoglobin; Hemolysis; Monocytes; Phagocytosis; Vascular system; Signal transduction DO - http://dx.doi.org/10.1089/ars.2009.2799 ER - TY - JOUR T1 - A functional quantitative polymerase chain reaction assay for ricin, Shiga toxin, and related ribosome-inactivating proteins AN - 21184000; 11351084 AB - The potent toxins ricin, abrin, and other ribosome-inactivating proteins deadenylate a specific base in 28S ribosomal RNA that destroys ribosomes and leads to cell death. We have taken advantage of the fact that reverse transcriptase preferentially inserts an adenine opposite to an abasic site in RNA to create a quantitative polymerase chain reaction (PCR) assay to detect the damage. This assay detects as little as 30 pg of ricin. We used the assay to study enzymatic properties of ricin such as pH and temperature optima (pH 4.5-5.0 and 60 C). JF - Analytical Biochemistry AU - Melchior, William B AU - Tolleson, William H AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA, william.melchior@fda.hhs.gov Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 204 EP - 211 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 396 IS - 2 SN - 0003-2697, 0003-2697 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Ricin KW - Ribosome-inactivating proteins KW - Quantitative PCR KW - Reverse transcriptase KW - Temperature effects KW - Cell death KW - ribosome-inactivating protein KW - rRNA 28S KW - Adenine KW - Polymerase chain reaction KW - RNA-directed DNA polymerase KW - Ribosomes KW - pH effects KW - Shiga toxin KW - X 24370:Natural Toxins KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21184000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+functional+quantitative+polymerase+chain+reaction+assay+for+ricin%2C+Shiga+toxin%2C+and+related+ribosome-inactivating+proteins&rft.au=Melchior%2C+William+B%3BTolleson%2C+William+H&rft.aulast=Melchior&rft.aufirst=William&rft.date=2010-01-15&rft.volume=396&rft.issue=2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2009.09.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Temperature effects; Cell death; ribosome-inactivating protein; rRNA 28S; Ricin; Adenine; RNA-directed DNA polymerase; Polymerase chain reaction; Ribosomes; pH effects; Shiga toxin DO - http://dx.doi.org/10.1016/j.ab.2009.09.024 ER - TY - GEN T1 - The Program Manager's Guide to Evaluation, Second Edition AN - 1826540714; ED566135 AB - The Office of Planning, Research and Evaluation (OPRE), a unit within the Administration for Children and Families (ACF), is responsible for advising the Assistant Secretary for Children and Families on increasing the effectiveness and efficiency of programs to improve the economic and social well-being of children and families. In collaboration with ACF program offices and others, OPRE is responsible for performance management for ACF, conducts research and policy analyses, and develops and oversees research and evaluation projects to assess program performance and inform policy and practice. The Office provides guidance, analysis, technical assistance, and oversight to ACF programs on: strategic planning; performance measurement; research and evaluation methods; statistical, policy, and program analysis; and synthesis and dissemination of research and demonstration findings. Toward these ends, OPRE is happy to present an updated edition of "The Program Manager's Guide to Evaluation." The original guide has consistently been the most frequently accessed of OPRE's resources. The new edition has been updated to reflect currently accepted practices, up-to-date terminology, and issues to consider at this time. Tips, samples, and worksheets that were missing from the online version have been inserted back into the guide, as has a thoroughly updated appendix containing a comprehensive list of evaluation resources. Based on feedback within ACF, it was decided to focus on a single guide that includes examples that would be relevant to all ACF program areas, rather than create separate handbooks for each program. As with the original edition of "The Program Manager's Guide to Evaluation," this updated edition explains what program evaluation is, why evaluation is important, how to conduct an evaluation and understand the results, how to report evaluation findings, and how to use evaluation results to improve programs that benefit children and families. The following evaluation resources are appended: (1) Evaluation Manuals and Guides; (2) Online Evaluation Toolkits; (3) Other Online Resources; (4) Clearinghouses and Organizations; (5) Locating Information Collection Instruments/Measures; (6) Evaluation Consultants; and (7) Selected Bibliography. Y1 - 2010/01/15/ PY - 2010 DA - 2010 Jan 15 SP - 122 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Consultants KW - Contracts KW - Information Dissemination KW - Models KW - Evaluation Methods KW - Costs KW - Objectives KW - Program Implementation KW - Worksheets KW - Guidance KW - Planning KW - Informed Consent KW - Data Collection KW - Program Evaluation KW - Data Analysis KW - Data Interpretation KW - Information Sources KW - Program Administration KW - Personnel Selection KW - Evaluators KW - Design KW - Reports KW - Evaluation Criteria KW - Educational Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826540714?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - CPAPER T1 - Genetically Engineered Animals: Regulation, Research, and Opportunities for Collaboration T2 - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AN - 42368640; 5663039 JF - XVIII Conference on Plant and Animal Genome (PAG-XVIII) AU - Rudenko, Larisa Y1 - 2010/01/09/ PY - 2010 DA - 2010 Jan 09 KW - Genetic engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/42368640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.atitle=Genetically+Engineered+Animals%3A+Regulation%2C+Research%2C+and+Opportunities+for+Collaboration&rft.au=Rudenko%2C+Larisa&rft.aulast=Rudenko&rft.aufirst=Larisa&rft.date=2010-01-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+Conference+on+Plant+and+Animal+Genome+%28PAG-XVIII%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/18/18-pag.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-06 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phenylalanines at positions 88 and 159 of Ebolavirus envelope glycoprotein differentially impact envelope function. AN - 734162377; 19906395 AB - The envelope glycoprotein (GP) of Ebolavirus (EBOV) mediates viral entry into host cells. Through mutagenesis, we and other groups reported that two phenylalanines at positions 88 and 159 of GP are critical for viral entry. However, it remains elusive which steps of viral entry are impaired by F88 or F159 mutations and how. In this study, we further characterized these two phenylalanines through mutagenesis and examined the impact on GP expression, function, and structure. Our data suggest that F159 plays an indirect role in viral entry by maintaining EBOV GP's overall structure. In contrast, we did not detect any evidence for conformational differences in GP with F88 mutations. The data suggest that F88 influences viral entry during a step after cathepsin processing, presumably impacting viral fusion. JF - Virology AU - Ou, Wu AU - King, Harlan AU - Delisle, Josie AU - Shi, Dashuang AU - Wilson, Carolyn A AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, USA. Y1 - 2010/01/05/ PY - 2010 DA - 2010 Jan 05 SP - 135 EP - 142 VL - 396 IS - 1 KW - Membrane Glycoproteins KW - 0 KW - Viral Envelope Proteins KW - Phenylalanine KW - 47E5O17Y3R KW - Thermolysin KW - EC 3.4.24.27 KW - Index Medicus KW - Thermolysin -- physiology KW - Animals KW - HeLa Cells KW - Humans KW - Cercopithecus aethiops KW - Vero Cells KW - Structure-Activity Relationship KW - Membrane Glycoproteins -- chemistry KW - Viral Envelope Proteins -- chemistry KW - Membrane Glycoproteins -- physiology KW - Viral Envelope Proteins -- physiology KW - Ebolavirus -- physiology KW - Ebolavirus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734162377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Phenylalanines+at+positions+88+and+159+of+Ebolavirus+envelope+glycoprotein+differentially+impact+envelope+function.&rft.au=Ou%2C+Wu%3BKing%2C+Harlan%3BDelisle%2C+Josie%3BShi%2C+Dashuang%3BWilson%2C+Carolyn+A&rft.aulast=Ou&rft.aufirst=Wu&rft.date=2010-01-05&rft.volume=396&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=1096-0341&rft_id=info:doi/10.1016%2Fj.virol.2009.10.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-12-15 N1 - Date created - 2009-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.virol.2009.10.028 ER - TY - RPRT T1 - 2010 Summary of Advances in Autism Spectrum Disorder Research AN - 964182738; ED524618 AB - As part of the Combating Autism Act of 2006, the members of the Interagency Autism Coordinating Committee (IACC) are required to develop an annual "Summary of Advances" to describe each year's top advances in autism spectrum disorder (ASD) research. These advances represent significant progress in the early diagnosis of ASD, understanding the complex biology of the disorder, and identifying potential risk factors. They may also relate to work identifying effective treatments and services and studies of the national prevalence of ASD and necessary research infrastructure. This 2010 edition of the Summary of Advances provides short, plain language synopses of the top twenty research breakthroughs selected by the committee from a pool of 64 peer-reviewed articles nominated by the members. Articles are grouped according to the questions of the IACC Strategic Plan for ASD Research. Citations for the articles selected for the Summary of Advances, as well as a complete listing of those nominated, are included at the end of the document. [For "Summary of Advances in Autism Spectrum Disorder Research, 2009," see ED509370] Y1 - 2010 PY - 2010 DA - 2010 SP - 35 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Developmental Disabilities KW - Clinical Diagnosis KW - Pervasive Developmental Disorders KW - Intervention KW - Disability Identification KW - Neurological Impairments KW - Outcomes of Treatment KW - Evaluation Methods KW - Genetics KW - Symptoms (Individual Disorders) KW - Verbal Communication KW - Human Body KW - Child Development KW - Cytology KW - Research KW - Brain Hemisphere Functions KW - Youth KW - At Risk Persons KW - Etiology KW - Young Children KW - Genetic Disorders KW - Brain KW - Referral KW - Children KW - Behavior Problems KW - Screening Tests KW - Mental Retardation KW - Federal Legislation KW - Diagnostic Tests KW - Language Impairments KW - Early Intervention KW - Incidence KW - Autism KW - Strategic Planning KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964182738?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - 2010 Strategic Plan for Autism Spectrum Disorder Research. NIH Publication No. 10-7573 AN - 964182534; ED524616 AB - In developing the 2010 Strategic Plan for ASD (Autism Spectrum Disorder) Research, the Interagency Autism Coordinating Committee (IACC) updated the previous Plan to highlight the most pressing research needs and opportunities for the field today. The Plan, which must be annually updated in accordance with the Combating Autism Act (CAA) of 2006, provides a blueprint for autism research that is advisory to the Department of Health and Human Services and serves as a basis for partnerships with other agencies and private organizations involved in autism research and services. The Plan and its revisions were developed through extensive and iterative input from members of the public, academic, and advocacy communities. This 2010 Strategic Plan incorporates this array of input in two main sections. First, the foundation of the Plan--vision, mission, core values, and crosscutting themes--is described. The remainder of the Plan is organized around seven critical questions asked by people and families living with ASD. These questions are: (1) When should I be concerned?; (2) How can I understand what is happening?; (3) What caused this to happen and can this be prevented?; (4) Which treatments and interventions will help?; (5) Where can I turn for services?; (6) What does the future hold, particularly for adults?; and (7) What other infrastructure and surveillance needs must be met? Each question is followed by a brief discussion of what individuals currently know and need from research, an aspirational goal, research opportunities and objectives. This framework was chosen by the IACC to emphasize the need for consumer-focused research that addresses the most pressing questions of people and families living with ASD, and to link these questions to specific research efforts. [For "2009 Strategic Plan for Autism Spectrum Disorder Research," see ED509368.] Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 60 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - American Recovery and Reinvestment Act 2009 KW - ERIC, Resources in Education (RIE) KW - Clinical Diagnosis KW - Federal Aid KW - Private Financial Support KW - Pervasive Developmental Disorders KW - Intervention KW - Adults KW - Research Needs KW - Access to Information KW - Federal Programs KW - Access to Health Care KW - Research KW - Financial Support KW - At Risk Persons KW - Etiology KW - Needs Assessment KW - Screening Tests KW - Prevention KW - Federal Legislation KW - Public Agencies KW - Guides KW - Autism KW - Strategic Planning KW - Private Agencies KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/964182534?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - CGMP for PET Drugs: Important Steps to Take Now AN - 954601424; 14027715 JF - Journal of Nuclear Medicine AU - VanBrocklin, Henry AU - Schwarz, Sally AD - Cochairs, SNM FDA Task Force Y1 - 2010 PY - 2010 DA - 2010 SP - 17N PB - Society of Nuclear Medicine VL - 51 IS - 12 SN - 0161-5505, 0161-5505 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954601424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nuclear+Medicine&rft.atitle=CGMP+for+PET+Drugs%3A+Important+Steps+to+Take+Now&rft.au=VanBrocklin%2C+Henry%3BSchwarz%2C+Sally&rft.aulast=VanBrocklin&rft.aufirst=Henry&rft.date=2010-01-01&rft.volume=51&rft.issue=12&rft.spage=17N&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 ER - TY - JOUR T1 - Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells AN - 954598466; 14027614 AB - Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone. Mutated skeletal stem cells lose the ability to differentiate into adipocytes, and to maintain in situ, and transfer heterotopically, the hematopoietic microenvironment, leading to abnormal bone marrow histology in FD. They overexpress molecular effectors of osteoclastogenesis, thus promoting inappropriate bone resorption leading to fragility of FD bone. They express the phosphate-regulating hormone FGF-23 at normal levels, whose excess in the serum of FD patients correlates with the mass of osteogenic cells within FD lesions, leading to osteomalacia and deformity of the FD bone, and revealing that bone is an endocrine organ regulating renal handling of phosphate. Mechanisms of allelic selection and stem cell selection occur in mutated skeletal stem cells and contribute to the inherent diversity and evolution over time in FD. The definition of the etiological role of GNAS mutations marks the watershed between many decades of descriptive observation and the definition of cellular and molecular mechanisms that would explain and hopefully allow for a cure for the disease. Placing stem cells at center stage has permitted substantial advances in one decade, and promises more for the one to come. JF - Journal of Molecular Endocrinology AU - Riminucci, Mara AU - Gehron Robey, Pamela AU - Saggio, Isabella AU - Bianco, Paolo AD - Department of Molecular Medicine, La Sapienza University, 00161 Rome, Italy , Biomedical Science Park San Raffaele, 00128 Rome, Italy , Department of Health and Human Services, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA , Department of Genetics and Molecular Biology, Sapienza University of Rome, and Institute for Molecular Biology and Pathology, National Research Council (CNR), 00185 Rome, Italy Y1 - 2010 PY - 2010 DA - 2010 SP - 355 EP - 364 PB - Society for Endocrinology VL - 45 IS - 6 SN - 0952-5041, 0952-5041 KW - Genetics Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - GNAS protein KW - Fibroblast growth factor 23 KW - Bone marrow KW - Watersheds KW - Bone dysplasia KW - Hormones KW - Bone strength KW - Fibrous dysplasia KW - Stem cells KW - Phosphate KW - Renal function KW - Adipocytes KW - Kidney KW - Bone resorption KW - Microenvironments KW - Hemopoiesis KW - Bone mass KW - Osteomalacia KW - Osteoclastogenesis KW - Mutation KW - Evolution KW - W 30940:Products KW - G 07730:Development & Cell Cycle KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954598466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Endocrinology&rft.atitle=Skeletal+progenitors+and+the+GNAS+gene%3A+fibrous+dysplasia+of+bone+read+through+stem+cells&rft.au=Riminucci%2C+Mara%3BGehron+Robey%2C+Pamela%3BSaggio%2C+Isabella%3BBianco%2C+Paolo&rft.aulast=Riminucci&rft.aufirst=Mara&rft.date=2010-01-01&rft.volume=45&rft.issue=6&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Endocrinology&rft.issn=09525041&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; GNAS protein; Fibroblast growth factor 23; Bone marrow; Bone dysplasia; Watersheds; Bone strength; Hormones; Fibrous dysplasia; Stem cells; Renal function; Phosphate; Adipocytes; Kidney; Hemopoiesis; Microenvironments; Bone resorption; Bone mass; Osteomalacia; Osteoclastogenesis; Mutation; Evolution ER - TY - JOUR T1 - What Changes In Survival Rates Tell Us About US Health Care AN - 954591514; 13967081 AB - Many advocates of US health reform point to the nation's relatively low life-expectancy rankings as evidence that the health care system is performing poorly. Others say that poor US health outcomes are largely due not to health care but to high rates of smoking, obesity, traffic fatalities, and homicides. We used cross-national data on the fifteen-year survival of men and women over three decades to examine the validity of these arguments. We found that the risk profiles of Americans generally improved relative to those for citizens of many other nations, but Americans' relative fifteen-year survival has nevertheless been declining. For example, by 2005, fifteen-year survival rates for forty-five-year-old US white women were lower than in twelve comparison countries with populations of at least seven million and per capita gross domestic product (GDP) of at least 60 percent of US per capita GDP in 1975. The findings undercut critics who might argue that the US health care system is not in need of major changes. JF - Health Affairs AU - Muennig, Peter A AU - Glied, Sherry A AD - Peter A. Muennig is an assistant professor of health policy and management at the Mailman School of Public Health, Columbia University, in New York City. Sherry A. Glied is a professor of health policy and management at the Mailman School of Public Health, currently on leave at the Department of Health and Human Services (HHS), where she is assistant secretary for planning and evaluation. This paper was written prior to her appointment at HHS and does not reflect the official views of HHS., pm124@columbia.edu Y1 - 2010 PY - 2010 DA - 2010 SP - 2105 EP - 2113 PB - Project Hope, 7500 Old Georgetown Rd. Suite 600 Bethesda MD 20814-6133 USA VL - 29 IS - 11 SN - 0278-2715, 0278-2715 KW - Health & Safety Science Abstracts KW - Mortality KW - homicide KW - obesity KW - Smoking KW - USA KW - traffic KW - Health care KW - survival KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954591514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=What+Changes+In+Survival+Rates+Tell+Us+About+US+Health+Care&rft.au=Muennig%2C+Peter+A%3BGlied%2C+Sherry+A&rft.aulast=Muennig&rft.aufirst=Peter&rft.date=2010-01-01&rft.volume=29&rft.issue=11&rft.spage=2105&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-04-23 N1 - SubjectsTermNotLitGenreText - Mortality; Smoking; homicide; traffic; Health care; obesity; survival; USA ER - TY - JOUR T1 - Water Safety Plan demonstration projects in Latin America and the Caribbean: lessons from the field AN - 911155149; 16066923 AB - A Water Safety Plan (WSP) is a preventive, risk management approach to ensure drinking water safety. This emerging methodology is being increasingly applied in both industrialized and lower income countries worldwide. In 2006, the U.S. Centers for Disease Control and Prevention (CDC) and other local, national, and international partners in Latin America and the Caribbean (LAC) initiated a series of WSP demonstration projects. The objectives were to raise WSP awareness, build capacity, and promote adoption of the WSP approach while identifying those factors that aid or hinder water safety planning efforts in resource-challenged settings. This paper presents eleven lessons learned from these WSP demonstration projects, including the importance of assembling a well-supported interagency team, long-term commitment to WSP implementation, adherence to a water quality monitoring plan, and determining how WSP impacts will be evaluated prior to WSP initiation. To assist in supporting future WSP activity in the region, this paper shares experiences that led to these successes, challenges, and lessons learned. JF - Water Science & Technology: Water Supply AU - Rinehold, Angella AU - Corrales, Lana AU - Medlin, Elizabeth AU - Gelting, Richard J AD - Global Water, Sanitation and Hygiene Team, Environmental Health Services Branch, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, GA, USA, rgelting@cdc.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 297 EP - 308 PB - IWA Publishing, Alliance House London SW1H 0QS United Kingdom VL - 10 IS - 1 SN - 1606-9749, 1606-9749 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Risk Abstracts; Pollution Abstracts; Sustainability Science Abstracts; Water Resources Abstracts; Environment Abstracts; Aqualine Abstracts KW - Pollution monitoring KW - Water Supply KW - Disease control KW - Water quality KW - Water supplies KW - Income KW - ASW, Caribbean Sea KW - Drinking Water KW - Planning KW - Regional planning KW - Latin America KW - Safety KW - Water Quality KW - Water supply KW - Risk KW - Risk management KW - USA KW - Prevention KW - Water management KW - Capacity KW - Monitoring KW - Drinking water KW - National planning KW - AQ 00007:Industrial Effluents KW - P 2000:FRESHWATER POLLUTION KW - M3 1010:Issues in Sustainable Development KW - Q5 08502:Methods and instruments KW - SW 3060:Water treatment and distribution KW - ENA 16:Renewable Resources-Water KW - R2 23070:Economics, organization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/911155149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Science+%26+Technology%3A+Water+Supply&rft.atitle=Water+Safety+Plan+demonstration+projects+in+Latin+America+and+the+Caribbean%3A+lessons+from+the+field&rft.au=Rinehold%2C+Angella%3BCorrales%2C+Lana%3BMedlin%2C+Elizabeth%3BGelting%2C+Richard+J&rft.aulast=Rinehold&rft.aufirst=Angella&rft.date=2010-01-01&rft.volume=10&rft.issue=1&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Water+Science+%26+Technology%3A+Water+Supply&rft.issn=16069749&rft_id=info:doi/10.2166%2Fws.2011.050 L2 - http://www.iwaponline.com/ws/01103/ws011030297.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-12-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Drinking Water; Water management; Planning; Disease control; Regional planning; Water quality; National planning; Water supply; Risk management; Prevention; Drinking water; Water supplies; Income; Risk; Safety; Water Supply; Water Quality; Capacity; Monitoring; USA; ASW, Caribbean Sea; Latin America DO - http://dx.doi.org/10.2166/ws.2011.050 ER - TY - JOUR T1 - Predictive Ability of Positive Clinical Culture Results and International Classification of Diseases, Ninth Revision, to Identify and Classify Noninvasive Staphylococcus aureus Infections: A Validation Study AN - 907159567; 14771388 AB - Objective. To develop and validate an algorithm to identify and classify noninvasive infections due to Staphylococcus aureus by using positive clinical culture results and administrative data. Design. Retrospective cohort study. Setting. Veterans Affairs Maryland Health Care System. Methods. Data were collected retrospectively on all S. aureus clinical culture results from samples obtained from nonsterile body sites during October 1998 through September 2008 and associated administrative claims records. An algorithm was developed to identify noninvasive infections on the basis of a unique S. aureus-positive culture result from a nonsterile site sample with a matching International Classification of Diseases, Ninth Revision (ICD-9-CM), code for infection at time of sampling. Medical records of a subset of cases were reviewed to find the proportion of true noninvasive infections (cases that met the Centers for Disease Control and Prevention National Healthcare Safety Network [NHSN] definition of infection). Positive predictive value (PPV) and negative predictive value (NPV) were calculated for all infections and according to body site of infection. Results. We identified 4,621 unique S. aureus-positive culture results, of which 2,816 (60.9%) results met our algorithm definition of noninvasive S. aureus infection and 1,805 (39.1%) results lacked a matching ICD-9-CM code. Among 96 cases that met our algorithm criteria for noninvasive S. aureus infection, 76 also met the NHSN criteria (PPV, 79.2% [95% confidence interval, 70.0%-86.1%]). Among 98 cases that failed to meet the algorithm criteria, 80 did not meet the NHSN criteria (NPV, 81.6% [95% confidence interval, 72.8%-88.0%]). The PPV of all culture results was 55.4%. The algorithm was most predictive for skin and soft-tissue infections and bone and joint infections. Conclusion. When culture-based surveillance methods are used, the addition of administrative ICD-9-CM codes for infection can increase the PPV of true noninvasive S. aureus infection over the use of positive culture results alone. JF - Infection Control and Hospital Epidemiology AU - Tracy, LaRee A AU - Furuno, Jon P AU - Harris, Anthony D AU - Singer, Mary AU - Langenberg, Patricia AU - Roghmann, Mary-Claire AD - Department of Epidemiology and Preventive Medicine, University of Maryland (L.A.T., J.P.F., A.D.H., P.L., M.-C.R.), and the Medical Care Clinical Center, Veterans Affairs Maryland Health Care System (M.-C.R.), Baltimore, and the Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring (M.S.), Maryland., ltracy@epi.umaryland.edu Y1 - 2010 PY - 2010 DA - 2010 SP - 694 EP - 700 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 31 IS - 7 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Skin KW - medical records KW - Algorithms KW - Joint diseases KW - Disease control KW - Infection KW - Classification KW - Reviews KW - Sampling KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/907159567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Predictive+Ability+of+Positive+Clinical+Culture+Results+and+International+Classification+of+Diseases%2C+Ninth+Revision%2C+to+Identify+and+Classify+Noninvasive+Staphylococcus+aureus+Infections%3A+A+Validation+Study&rft.au=Tracy%2C+LaRee+A%3BFuruno%2C+Jon+P%3BHarris%2C+Anthony+D%3BSinger%2C+Mary%3BLangenberg%2C+Patricia%3BRoghmann%2C+Mary-Claire&rft.aulast=Tracy&rft.aufirst=LaRee&rft.date=2010-01-01&rft.volume=31&rft.issue=7&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F653206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Skin; Data processing; Classification; medical records; Reviews; Disease control; Joint diseases; Algorithms; Sampling; Infection; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1086/653206 ER - TY - JOUR T1 - Pathology Peer Review AN - 904468450; 14267307 JF - Toxicologic Pathology AU - Boorman, Gary A AU - Wolf, Douglas C AU - Francke-Carroll, Sabine AU - Maronpot, Robert R AD - Covance Inc., Vienna, Virginia, USA. U.S. EPA, Research Triangle Park, North Carolina, USA. U.S. FDA, College Park, Maryland, USA. Maronpot Consulting LLC, Raleigh, North Carolina, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 1009 EP - 1010 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904468450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Pathology+Peer+Review&rft.au=Boorman%2C+Gary+A%3BWolf%2C+Douglas+C%3BFrancke-Carroll%2C+Sabine%3BMaronpot%2C+Robert+R&rft.aulast=Boorman&rft.aufirst=Gary&rft.date=2010-01-01&rft.volume=38&rft.issue=7&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 ER - TY - JOUR T1 - An Evaluation of the Methods for Deriving Representative Frequency Response Functions of the Human Whole-body System AN - 904463363; 14249535 AB - The biodynamic response functions of the human whole-body system measured with subjects participating in an experiment are commonly arithmetically averaged and used to represent their mean response functions in many studies. The reported means were further averaged to form the reference means for standardization and various applications. The objectives of this study are to clarify whether this response-based averaging process could significantly misrepresent the characteristics of the original functions, and to explore appropriate methods for deriving representative functions. A set of reported mechanical-equivalent models for 12 subjects was used to derive the vertical and fore-and-aft cross-axis response functions expressed in apparent mass. The response-based average was directly compared with the response derived from a property-based derivation method. This study found that the response-based average could differ from the property-based mean response by more than 30%, especially in the fore-and-aft cross-axis response functions. This study also theoretically demonstrated that the discrepancies result from the non-linear relationship between the apparent mass and the properties of a dynamic system. Therefore, the discrepancies depend on the variability of the subjects' dynamic properties. Practically, the discrepancies in the vertical response could be reduced to an acceptable level (e.g., -10%) if a sufficient number of subjects with similar body weights are selected or grouped in the measurement. However, it is very difficult to reduce the discrepancies in the fore-and-aft cross-axis to such a level. While more demanding than the response-based method, the property-based method is theoretically more reliable for deriving the representative response functions for each axis. JF - Industrial Health AU - Dong, Ren G AU - Mcdowell, Thomas W AU - Welcome, Daniel E AU - Wu, John Z AD - National Institute for Occupational Safety and Health, Engineering & Control Technology Branch Y1 - 2010 PY - 2010 DA - 2010 SP - 596 EP - 605 PB - National Institute of Industrial Health. Japan., 21-1 Nagao 6-chome Kawasaki-shi 214-0023 Kanagawa-ken Japan VL - 48 IS - 5 SN - 1880-8026, 1880-8026 KW - Health & Safety Science Abstracts KW - Standards KW - body weight KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=An+Evaluation+of+the+Methods+for+Deriving+Representative+Frequency+Response+Functions+of+the+Human+Whole-body+System&rft.au=Dong%2C+Ren+G%3BMcdowell%2C+Thomas+W%3BWelcome%2C+Daniel+E%3BWu%2C+John+Z&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2010-01-01&rft.volume=48&rft.issue=5&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=18808026&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Standards; body weight ER - TY - JOUR T1 - Dietary Factors and Risk of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: A Pooled Analysis of Two Prospective Studies AN - 904463327; 14152583 AB - BACKGROUND: Other than male sex, family history, advanced age, and race, risk factors for chronic lymphocytic leukemia and small lymphocytic lymphoma (CLL/SLL) are unknown. Very few studies have investigated diet in relation to these leukemias, and no consistent associations are known. METHODS: Using two large prospective population-based studies, we evaluated the relationship between diet and CLL/SLL risk. Among 525,982 men and women free of cancer at enrollment, we identified 1,129 incident CLL/SLL cases during 11.2 years of follow-up. RESULTS: We found no associations between total fat, saturated fat, fiber, red meat, processed meat, fruit, or vegetable intake and risk of CLL/SLL. We noted a suggestive positive association between body mass index and CLL/SLL (hazard ratio, 1.30; 95% confidence interval, 0.99-1.36). CONCLUSION: We did not find any associations between food or nutrient intake and CLL/SLL. IMPACT: Our large prospective study indicates that diet may not play a role in CLL/SLL development. Cancer Epidemiol Biomarkers Prev; 19(10); 2680-4. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Tsai, Huei-Ting AU - Cross, Amanda J AU - Graubard, Barry I AU - Oken, Martin AU - Schatzkin, Arthur AU - Caporaso, Neil E AD - Authors' Affiliations: Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2680 EP - 2684 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 10 SN - 1055-9965, 1055-9965 KW - Immunology Abstracts; Toxicology Abstracts; Risk Abstracts KW - Age KW - Chronic lymphatic leukemia KW - Cancer KW - F 06915:Cancer Immunology KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/904463327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Dietary+Factors+and+Risk+of+Chronic+Lymphocytic+Leukemia+and+Small+Lymphocytic+Lymphoma%3A+A+Pooled+Analysis+of+Two+Prospective+Studies&rft.au=Tsai%2C+Huei-Ting%3BCross%2C+Amanda+J%3BGraubard%2C+Barry+I%3BOken%2C+Martin%3BSchatzkin%2C+Arthur%3BCaporaso%2C+Neil+E&rft.aulast=Tsai&rft.aufirst=Huei-Ting&rft.date=2010-01-01&rft.volume=19&rft.issue=10&rft.spage=2680&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Chronic lymphatic leukemia; Cancer ER - TY - JOUR T1 - In Vitro Dermal Penetration of 4-Chloro-3-Methylphenol from Commercial Metal Working Fluid and Aqueous Vehicles AN - 899141853; 14322727 AB - Abstract not available. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Frasch, H Frederick AU - Zang, Lun-Yi AU - Barbero, Ana M AU - Anderson, Stacey E AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1394 EP - 1405 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 73 IS - 20 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899141853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=In+Vitro+Dermal+Penetration+of+4-Chloro-3-Methylphenol+from+Commercial+Metal+Working+Fluid+and+Aqueous+Vehicles&rft.au=Frasch%2C+H+Frederick%3BZang%2C+Lun-Yi%3BBarbero%2C+Ana+M%3BAnderson%2C+Stacey+E&rft.aulast=Frasch&rft.aufirst=H&rft.date=2010-01-01&rft.volume=73&rft.issue=20&rft.spage=1394&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2010.497444 L2 - http://www.informaworld.com/smpp/content~db=all~content=a926544523~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Metals DO - http://dx.doi.org/10.1080/15287394.2010.497444 ER - TY - JOUR T1 - Mutagenicity of Diesel Exhaust Particles from an Engine with Differing Exhaust After Treatments AN - 899141807; 14322713 AB - Abstract not available. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Shi, X -C AU - Keane, M J AU - Ong, T AU - Li, S-Q AU - Bugarski, A B AD - U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1314 EP - 1324 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 73 IS - 19 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Diesel engines KW - Exhaust emissions KW - Mutagenicity KW - Particulates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899141807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Mutagenicity+of+Diesel+Exhaust+Particles+from+an+Engine+with+Differing+Exhaust+After+Treatments&rft.au=Shi%2C+X+-C%3BKeane%2C+M+J%3BOng%2C+T%3BLi%2C+S-Q%3BBugarski%2C+A+B&rft.aulast=Shi&rft.aufirst=X&rft.date=2010-01-01&rft.volume=73&rft.issue=19&rft.spage=1314&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2010.485030 L2 - http://www.informaworld.com/smpp/content~db=all~content=a925758721~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-09-24 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Particulates; Diesel engines; Exhaust emissions DO - http://dx.doi.org/10.1080/15287394.2010.485030 ER - TY - JOUR T1 - Statistical considerations in evaluating pharmacogenomics-based clinical effect for confirmatory trials AN - 899130940; 13814803 AB - Background The current practice for seeking genomically favorable patients in randomized controlled clinical trials using genomic convenience samples. Purpose To discuss the extent of imbalance, confounding, bias, design efficiency loss, type I error, and type II error that can occur in the evaluation of the convenience samples, particularly when they are small samples. To articulate statistical considerations for a reasonable sample size to minimize the chance of imbalance, and, to highlight the importance of replicating the subgroup finding in independent studies. Methods Four case examples reflecting recent regulatory experiences are used to underscore the problems with convenience samples. Probability of imbalance for a pre-specified subgroup is provided to elucidate sample size needed to minimize the chance of imbalance. We use an example drug development to highlight the level of scientific rigor needed, with evidence replicated for a pre-specified subgroup claim. Results The convenience samples evaluated ranged from 18% to 38% of the intent-to-treat samples with sample size ranging from 100 to 5000 patients per arm. The baseline imbalance can occur with probability higher than 25%. Mild to moderate multiple confounders yielding the same directional bias in favor of the treated group can make treatment group incomparable at baseline and result in a false positive conclusion that there is a treatment difference. Conversely, if the same directional bias favors the placebo group or there is loss in design efficiency, the type II error can increase substantially. Limitations Pre-specification of a genomic subgroup hypothesis is useful only for some degree of type I error control. Conclusion Complete ascertainment of genomic samples in a randomized controlled trial should be the first step to explore if a favorable genomic patient subgroup suggests a treatment effect when there is no clear prior knowledge and understanding about how the mechanism of a drug target affects the clinical outcome of interest. When stratified randomization based on genomic biomarker status cannot be implemented in designing a pharmacogenomics confirmatory clinical trial, if there is one genomic biomarker prognostic for clinical response, as a general rule of thumb, a sample size of at least 100 patients may be needed to be considered for the lower prevalence genomic subgroup to minimize the chance of an imbalance of 20% or more difference in the prevalence of the genomic marker. The sample size may need to be at least 150, 350, and 1350, respectively, if an imbalance of 15%, 10% and 5% difference is of concern. Clinical Trials 2010; 7: 525-536. http://ctj.sagepub.com JF - Clinical Trials AU - Wang, Sue-Jane AU - O'Neill, Robert T AU - Hung, HM James AD - Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA, suejane.wangda.hhs.gov Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA. Division of Biometrics I, Office of Biostatistics, OTS, Center for Drug Evaluation and Research, U.S. FDA, Silver Spring, MD, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 525 EP - 536 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 7 IS - 5 SN - 1740-7745, 1740-7745 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Clinical trials KW - Drug development KW - Drugs KW - Statistics KW - biomarkers KW - genomics KW - pharmacogenomics KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899130940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Statistical+considerations+in+evaluating+pharmacogenomics-based+clinical+effect+for+confirmatory+trials&rft.au=Wang%2C+Sue-Jane%3BO%27Neill%2C+Robert+T%3BHung%2C+HM+James&rft.aulast=Wang&rft.aufirst=Sue-Jane&rft.date=2010-01-01&rft.volume=7&rft.issue=5&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-05-18 N1 - SubjectsTermNotLitGenreText - Statistics; pharmacogenomics; Drug development; genomics; Drugs; biomarkers; Clinical trials ER - TY - JOUR T1 - Rising Social Inequalities in US Childhood Obesity, 2003-2007 AN - 883020834; 15374838 JF - Annals of Epidemiology AU - Singh, Gopal K AU - Siahpush, Mohammad AU - Kogan, Michael D AD - U.S. Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child Health Bureau, Rockville, MD, gsingh@hrsa.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 40 EP - 52 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 20 IS - 1 SN - 1047-2797, 1047-2797 KW - Health & Safety Science Abstracts KW - USA KW - obesity KW - Children KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883020834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Rising+Social+Inequalities+in+US+Childhood+Obesity%2C+2003-2007&rft.au=Singh%2C+Gopal+K%3BSiahpush%2C+Mohammad%3BKogan%2C+Michael+D&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2010-01-01&rft.volume=20&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2009.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - obesity; Children; USA DO - http://dx.doi.org/10.1016/j.annepidem.2009.09.008 ER - TY - JOUR T1 - Early Events in Vascular Injury in the Rat Induced by the Phosphodiesterase IV Inhibitor SCH 351591 AN - 877599147; 13722225 AB - Treatment with drugs from multiple classes induces vascular injury with medial necrosis, hemorrhage, endothelial damage, and inflammation. Previous research has suggested early events might be occurring well in advance of the full lesions that appear forty-eight to seventy-two hours after dosing with SCH 351591, a PDE IV inhibitor. This study was performed to study early events in detail. Rats were dosed with 20 mg/kg of drug by gavage and sacrificed at times between fifteen and 240 minutes after dosing. Tissues were collected for histopathological analysis and gene expression studies. Serum was collected for biomarker analysis. The data from biomarker analysis showed a three-part response with an early phase that was maximal at fifteen to thirty minutes, a second phase from forty-five to 180 minutes, and the third phase that was starting to rise at four hours. The first phase included increases in lymphocytes, serum histamine, and serum nitrite. The second phase shows continued elevation of serum nitrite. The third phase was marked by an increase in serum GRO/CINC-1. At fifteen minutes, histopathology showed activation of mast cells, but not degranulation. Increases in endothelial activation and perivascular inflammatory cells were first apparent at thirty minutes and increased through 240 minutes. JF - Toxicologic Pathology AU - Weaver, James L AU - Zhang, Jun AU - Knapton, Alan AU - Miller, Terry AU - Espandiari, Parvaneh AU - Smith, Roger AU - Gu, Yi-Zhong AU - Snyder, Ronald D AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD Y1 - 2010 PY - 2010 DA - 2010 SP - 738 EP - 744 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Data processing KW - Injuries KW - Mast cells KW - Lymphocytes KW - Hemorrhage KW - phosphodiesterase IV KW - biomarkers KW - Histamine KW - Inflammation KW - Gene expression KW - Necrosis KW - Degranulation KW - phosphodiesterase IV inhibitors KW - Nitrite KW - Drugs KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877599147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Early+Events+in+Vascular+Injury+in+the+Rat+Induced+by+the+Phosphodiesterase+IV+Inhibitor+SCH+351591&rft.au=Weaver%2C+James+L%3BZhang%2C+Jun%3BKnapton%2C+Alan%3BMiller%2C+Terry%3BEspandiari%2C+Parvaneh%3BSmith%2C+Roger%3BGu%2C+Yi-Zhong%3BSnyder%2C+Ronald+D&rft.aulast=Weaver&rft.aufirst=James&rft.date=2010-01-01&rft.volume=38&rft.issue=5&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Mast cells; Lymphocytes; Hemorrhage; biomarkers; phosphodiesterase IV; Inflammation; Histamine; Gene expression; Necrosis; Degranulation; phosphodiesterase IV inhibitors; Nitrite; Drugs ER - TY - JOUR T1 - Running a tightrope: Regulatory challenges in the development of antiretrovirals AN - 877571048; 13011379 AB - Since the approval of Retrovir, (zidovudine, AZT) in 1987 by the Food and Drug Administration, a number of regulatory initiatives were codified into regulation which contributed to the rapid development of new treatments for HIV-1 infection. These initiatives are a testament to the efforts of AIDS activists and regulators to improve access to drugs for serious and life-threatening diseases. Currently, 28 antiretroviral drugs and combinations of antiretrovirals are available to treat HIV-1 infection. The broadening armamentarium of approved antiretroviral drugs provides new options and more choices for physicians and HIV patients. Importantly, the introduction of these newly approved HIV drugs has shown that the majority of HIV-1-infected treatment-naive and treatment-experienced patients can achieve maximal virologic suppression (less than 50copies/mL HIV-1 RNA). This article describes the past and current regulatory challenges in the development of new HIV treatments and provides an overview of the drug regulations that were required for the approval of HIV drugs. This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010. JF - Antiviral Research AU - Naeger, Lisa K AU - Struble, Kimberly A AU - Murray, Jeffrey S AU - Birnkrant, Debra B AD - Division of Antiviral Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States, lisa.naeger@fda.hhs.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 232 EP - 240 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 85 IS - 1 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - HIV-1 KW - Drug regulations KW - Accelerated approval KW - Surrogate endpoint KW - Fast track KW - Clinical trial designs KW - Resistance KW - PEPFAR KW - Expanded access KW - Drug discovery KW - Acquired immune deficiency syndrome KW - Antiviral agents KW - RNA KW - Running KW - Reviews KW - Human immunodeficiency virus 1 KW - Zidovudine KW - Drug development KW - Infection KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877571048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Running+a+tightrope%3A+Regulatory+challenges+in+the+development+of+antiretrovirals&rft.au=Naeger%2C+Lisa+K%3BStruble%2C+Kimberly+A%3BMurray%2C+Jeffrey+S%3BBirnkrant%2C+Debra+B&rft.aulast=Naeger&rft.aufirst=Lisa&rft.date=2010-01-01&rft.volume=85&rft.issue=1&rft.spage=232&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2009.07.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Drug discovery; Acquired immune deficiency syndrome; RNA; Antiviral agents; Reviews; Running; Zidovudine; Drug development; Infection; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.antiviral.2009.07.016 ER - TY - JOUR T1 - ICH Guidelines: Inception, Revision, and Implications for Drug Development AN - 872130207; 14106483 JF - Toxicological Sciences AU - Wang, Tao AU - Jacobson-Kram, David AU - Pilaro, Anne M AU - Lapadula, Daniel AU - Jacobs, Abigail AU - Brown, Paul AU - Lipscomb, John AU - McGuinn, William David AD - Preclinical Safety, Novartis Pharmaceuticals Corporation, Emeryville, California 94608. Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Preclinical Safety, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936. National Center for Environmental Assessment, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268 Y1 - 2010 PY - 2010 DA - 2010 SP - 356 EP - 367 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 118 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872130207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=ICH+Guidelines%3A+Inception%2C+Revision%2C+and+Implications+for+Drug+Development&rft.au=Wang%2C+Tao%3BJacobson-Kram%2C+David%3BPilaro%2C+Anne+M%3BLapadula%2C+Daniel%3BJacobs%2C+Abigail%3BBrown%2C+Paul%3BLipscomb%2C+John%3BMcGuinn%2C+William+David&rft.aulast=Wang&rft.aufirst=Tao&rft.date=2010-01-01&rft.volume=118&rft.issue=2&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2012-03-29 ER - TY - JOUR T1 - Bacterial Vaginosis Assessed by Gram Stain and Diminished Colonization Resistance to Incident Gonococcal, Chlamydial, and Trichomonal Genital Infection AN - 872127144; 14248365 AB - Background. We sought to assess the relationship between bacterial vaginosis (BV) assessed by Gram stain and incident trichomonal, gonococcal, and/or chlamydial genital infection. Methods. This longitudinal study included 3620 nonpregnant women aged 15-44 years who presented for routine care at 12 clinics in Birmingham, Alabama. Participants were assessed quarterly for 1 year. Vaginal smears were categorized by the Nugent Gram stain score (0-3, normal; 4-6, intermediate state; 7-10, BV). Pooled logistic regression was used to estimate the hazard ratios for the comparison of trichomonal, gonococcal, and chlamydial infection incidence in participants by Nugent score at the prior visit. Participants were censored at their first visit with a positive test result for trichomonal, gonococcal, and/or chlamydial infection. Results. Of the 10,606 eligible visits, 37.96% were classified by BV and 13.3% by positive detection of trichomonal, gonococcal, and/or chlamydial infection. An intermediate state or BV at the prior visit was associated with a 1.5-2-fold increased risk for incident trichomonal, gonococcal, and/or chlamydial infection (adjusted hazard ratio [AHR] for intermediate state, 1.41 [95% confidence interval {CI}, 1.12-1.76]; AHR for BV, 1.73 [95% CI, 1.42-2.11]; [inline image] for trend). Estimates were similar for trichomonal-only, gonococcal-only, and chlamydial-only infection outcomes. Conclusion. BV microbiota as gauged by Gram stain is associated with a significantly elevated risk for acquisition of trichomonal, gonococcal, and/or chlamydial genital infection. JF - Journal of Infectious Diseases AU - Brotman, Rebecca M AU - Klebanoff, Mark A AU - Nansel, Tonja R AU - Yu, Kai F AU - Andrews, William W AU - Zhang, Jun AU - Schwebke, Jane R AD - Institute for Genome Sciences and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, and Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, rbrotman@som.umaryland.edu Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 1907 EP - 1915 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA VL - 202 IS - 12 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteria KW - Colonization KW - Gram stain KW - Vagina KW - Infection KW - Vaginosis KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03400:Human Diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872127144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Bacterial+Vaginosis+Assessed+by+Gram+Stain+and+Diminished+Colonization+Resistance+to+Incident+Gonococcal%2C+Chlamydial%2C+and+Trichomonal+Genital+Infection&rft.au=Brotman%2C+Rebecca+M%3BKlebanoff%2C+Mark+A%3BNansel%2C+Tonja+R%3BYu%2C+Kai+F%3BAndrews%2C+William+W%3BZhang%2C+Jun%3BSchwebke%2C+Jane+R&rft.aulast=Brotman&rft.aufirst=Rebecca&rft.date=2010-01-01&rft.volume=202&rft.issue=12&rft.spage=1907&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1086%2F657320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Colonization; Gram stain; Vagina; Infection; Vaginosis; Bacteria DO - http://dx.doi.org/10.1086/657320 ER - TY - JOUR T1 - Screening biomaterials for functional complement activation in serum AN - 869574196; 14820530 AB - Complement plays an important role in the immune attack against invading microorganisms. However, blood-contacting medical device biomaterials lacking specific complement inhibitors, with free hydroxyl and/or amino groups, or with absorbed antibodies, may inappropriately activate complement. Inappropriate activation by either the antibody-mediated classical or the antibody-independent alternative pathway may have well-known acute or poorly understood chronic effects on the host or device. This article describes methods for screening biomaterials for functional whole complement activation using normal human serum, or specifically for alternative pathway activation using C4-deficient guinea pig serum, or for classical pathway activation using both sera in combination. Detailed protocols are available as standard methodologies from the American Society for Testing and Materials (ASTM F1984, ASTM F2065, and ASTM F2567). Results obtained with these functional tests are confirmed by detection of classical and alternative pathway-specific markers C4d and Bb, respectively. These methods demonstrate dose and time-course activation of complement to beaded agarose, cellulose acetate, and purified alginate as examples of biomaterials. Significant difference in a functional endpoint denoting specific complement pathways is an appropriate screening method for complement activation by medical device biomaterials which might result in adverse events when the device is implanted or contacts human blood. JF - Journal of Biomedical Materials Research, Part A AU - Lyle, Daniel B AU - Bushar, Grace S AU - Langone, John J AD - Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, FDA, 64-3036, 10903 New Hampshire Ave., Silver Spring, Maryland 20993, dan.lyle@fda.hhs.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 205 EP - 213 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 92A IS - 1 SN - 1552-4965, 1552-4965 KW - Biotechnology and Bioengineering Abstracts KW - complement activation KW - alternative pathway KW - classical pathway KW - biomaterials KW - screening KW - medical devices KW - Amino groups KW - Classical pathway KW - Alternative pathway KW - Blood KW - cellulose acetate KW - Antibodies KW - Alginic acid KW - Chronic effects KW - Complement activation KW - Biomaterials KW - Microorganisms KW - Complement inhibitors KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/869574196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.atitle=Screening+biomaterials+for+functional+complement+activation+in+serum&rft.au=Lyle%2C+Daniel+B%3BBushar%2C+Grace+S%3BLangone%2C+John+J&rft.aulast=Lyle&rft.aufirst=Daniel&rft.date=2010-01-01&rft.volume=92A&rft.issue=1&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+A&rft.issn=15524965&rft_id=info:doi/10.1002%2Fjbm.a.32281 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Alternative pathway; Blood; Antibodies; Amino groups; cellulose acetate; Alginic acid; Classical pathway; Chronic effects; Complement activation; Microorganisms; Biomaterials; Complement inhibitors DO - http://dx.doi.org/10.1002/jbm.a.32281 ER - TY - JOUR T1 - Biomarkers of Endothelial Cell Activation Serve as Potential Surrogate Markers for Drug-induced Vascular Injury AN - 867738008; 13919384 AB - Drug-induced vascular injury (DIVI) is a nonclinical finding that often confounds the toxicological evaluation of investigational drugs, but there is an absence of qualified biomarkers that can be used to detect and monitor its appearance in animals and patients during drug development and clinical use. It is well known that endothelial cell (EC) activation plays a key role in the expression and evolution of DIVI, and the various immunological and inflammatory factors involved in its expression may serve as potential biomarker candidates. Activated ECs change their morphology and gene expression, generating endothelial adhesion molecules, pro-coagulant molecules, cytokines, chemokines, vasodilators, nitric oxide, and acute-phase reactants. This review provides a brief historical background of EC activation and the search for biomarkers of early EC activation for monitoring DIVI. At present, no biomarkers of EC activation have been qualified to predict DIVI in the nonclinical or clinical context, and a robust pathologic foundation for their use is still lacking. We propose three categories of EC activation biomarkers: recommended surrogate markers, potentially useful markers, and emerging candidate markers. This review alerts pharmaceutical companies, research institutions, and regulatory agencies to the continuing need for reliable biomarkers of EC activation in drug development. JF - Toxicologic Pathology AU - Zhang, Jun AU - DeFelice, Albert F AU - Hanig, Joseph P AU - Colatsky, Thomas AD - Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 856 EP - 871 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Chemokines KW - Injuries KW - Drug development KW - biomarkers KW - Inflammation KW - Cell activation KW - Gene expression KW - Endothelial cells KW - Reviews KW - Cytokines KW - Pharmaceuticals KW - Nitric oxide KW - Evolution KW - Vasodilators KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/867738008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Biomarkers+of+Endothelial+Cell+Activation+Serve+as+Potential+Surrogate+Markers+for+Drug-induced+Vascular+Injury&rft.au=Zhang%2C+Jun%3BDeFelice%2C+Albert+F%3BHanig%2C+Joseph+P%3BColatsky%2C+Thomas&rft.aulast=Zhang&rft.aufirst=Jun&rft.date=2010-01-01&rft.volume=38&rft.issue=6&rft.spage=856&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Chemokines; Injuries; Drug development; biomarkers; Cell activation; Inflammation; Endothelial cells; Gene expression; Reviews; Pharmaceuticals; Cytokines; Nitric oxide; Evolution; Vasodilators ER - TY - JOUR T1 - Ground Failures in Coal Mines with Weak Roof AN - 862783051; 14543004 AB - Coal miners who work and travel under supported roof expect to be protected from rock falls. However, rock fall accidents and injuries continue to occur in coal mines that have been supported according to the roof control plan. Experience at coal mines with large numbers of falls indicates that many have weak roof. Control of this roof may require additional ground control measures. An understanding of the geologic and stress conditions which lead to roof falls is necessary to assess the risk of failure and to design roof reinforcement to improve stability. Six common roof fall types, with attached field examples, are described. Roof support practices for each fall type are also described. JF - Electronic Journal of Geotechnical Engineering AU - Molinda, G AU - Mark, C AD - National Institute for Occupational Safety and Health (NIOSH) P.O. Box 18070, Cochrans Mill Rd. Pgh, PA 15236, USA, cnm4@cdc.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 547 EP - 588 PB - Electronic Journal of Geotechnical Engineering VL - 15 IS - F SN - 1089-3032, 1089-3032 KW - Health & Safety Science Abstracts KW - Travel KW - Accidents KW - Injuries KW - Occupational safety KW - Stress KW - Geology KW - Coal KW - Mining KW - Mines KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/862783051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electronic+Journal+of+Geotechnical+Engineering&rft.atitle=Ground+Failures+in+Coal+Mines+with+Weak+Roof&rft.au=Molinda%2C+G%3BMark%2C+C&rft.aulast=Molinda&rft.aufirst=G&rft.date=2010-01-01&rft.volume=15&rft.issue=F&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Electronic+Journal+of+Geotechnical+Engineering&rft.issn=10893032&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Travel; Accidents; Injuries; Occupational safety; Stress; Geology; Mining; Coal; Mines ER - TY - JOUR T1 - Effects of in Utero Exposure to DI(n-Butyl) Phthalate on Development of Male Reproductive Tracts in Sprague-Dawley Rats AN - 860396622; 14322752 AB - Abstract not available. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Kim, Tae Sung AU - Jung, Ki Kyung AU - Kim, Soon Sun AU - Kang, Il Hyun AU - Baek, Jung Hee AU - Nam, Hye-Seon AU - Hong, Soon-Keun AU - Lee, Byung Mu AU - Hong, Jin Tae AU - Oh, Ki Wan AU - Kim, Hyung Sik AU - Han, Soon Young AU - Kang, Tae Seok AD - Health Effects Analysis Team, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, South Korea Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1544 EP - 1559 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 73 IS - 21 SN - 1528-7394, 1528-7394 KW - Pollution Abstracts; Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Rats KW - phthalates KW - Prenatal experience KW - males KW - Intrauterine exposure KW - Reproductive system KW - Phthalic acid KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860396622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Effects+of+in+Utero+Exposure+to+DI%28n-Butyl%29+Phthalate+on+Development+of+Male+Reproductive+Tracts+in+Sprague-Dawley+Rats&rft.au=Kim%2C+Tae+Sung%3BJung%2C+Ki+Kyung%3BKim%2C+Soon+Sun%3BKang%2C+Il+Hyun%3BBaek%2C+Jung+Hee%3BNam%2C+Hye-Seon%3BHong%2C+Soon-Keun%3BLee%2C+Byung+Mu%3BHong%2C+Jin+Tae%3BOh%2C+Ki+Wan%3BKim%2C+Hyung+Sik%3BHan%2C+Soon+Young%3BKang%2C+Tae+Seok&rft.aulast=Kim&rft.aufirst=Tae&rft.date=2010-01-01&rft.volume=73&rft.issue=21&rft.spage=1544&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2010.511579 L2 - http://www.informaworld.com/smpp/content~db=all~content=a928050395~frm=titlelink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Intrauterine exposure; Reproductive system; Phthalic acid; Rats; phthalates; Prenatal experience; males DO - http://dx.doi.org/10.1080/15287394.2010.511579 ER - TY - JOUR T1 - Gene Expression Profiling as an Initial Approach for Mechanistic Studies of Toxicity and Tumorigenicity of Herbal Plants and Herbal Dietary Supplements AN - 860374033; 14319363 AB - Abstract not available. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Guo, Lei AU - Mei, Nan AU - Xia, Qingsu AU - Chen, Tao AU - Chan, Po-Chuen AU - Fu, Peter P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, FDA, AR, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 60 EP - 87 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 28 IS - 1 SN - 1059-0501, 1059-0501 KW - Pollution Abstracts; Toxicology Abstracts KW - dietary supplements KW - Tumorigenicity KW - Toxicity KW - Gene expression KW - Reviews KW - Dietary supplements KW - Carcinogenesis KW - X 24320:Food Additives & Contaminants KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860374033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Gene+Expression+Profiling+as+an+Initial+Approach+for+Mechanistic+Studies+of+Toxicity+and+Tumorigenicity+of+Herbal+Plants+and+Herbal+Dietary+Supplements&rft.au=Guo%2C+Lei%3BMei%2C+Nan%3BXia%2C+Qingsu%3BChen%2C+Tao%3BChan%2C+Po-Chuen%3BFu%2C+Peter+P&rft.aulast=Guo&rft.aufirst=Lei&rft.date=2010-01-01&rft.volume=28&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590500903585416 L2 - http://www.informaworld.com/smpp/content~db=all~content=a920001920~frm=abslink LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Dietary supplements; Carcinogenesis; Tumorigenicity; Toxicity; dietary supplements; Reviews DO - http://dx.doi.org/10.1080/10590500903585416 ER - TY - JOUR T1 - Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice AN - 856770761; 14152232 AB - Acrylamide (AA) is an industrial chemical, a by-product of fried starchy foods, and a mutagen and rodent carcinogen. It can also cause damage during spermatogenesis. In this study, we investigated whether AA and its metabolite glycidamide (GA) induce mutagenic effects in the germ cells of male mice. Male Big Blue transgenic mice were administered 1.4 or 7.0mM of AA or GA in the drinking water for up to 4 weeks. Testicular cII mutant frequency (MF) was determined 3 weeks after the last treatment, and the types of the mutations in the cII gene were analyzed by DNA sequencing. The testes cII MFs in mice treated with either the low or high exposure concentrations of AA and GA were increased significantly. There was no significant difference in the cII MFs between AA and GA at the low exposure concentration. The mutation spectra in mice treated with AA (1.4mM) or GA (both 1.4 and 7.0mM) differed significantly from those of controls, but there were no significant differences in mutation patterns between AA and GA treatments. Comparison of the mutation spectra between testes and livers showed that the spectra differed significantly between the two tissues following treatment with AA or GA, whereas the mutation spectra in the two tissues from control mice were similar. These results suggest that AA possesses mutagenic effects on testes by virtue of its metabolism to GA, possibly targeting spermatogonial stem cells, but possibly via different pathways when compared mutations in liver. JF - Toxicological Sciences AU - Wang, Rui-Sheng AU - McDaniel, Lea P AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Doerge, Daniel R AU - Mei, Nan AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079 Y1 - 2010 PY - 2010 DA - 2010 SP - 72 EP - 80 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 117 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Acrylamide KW - Mutation KW - X:24320 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856770761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Mutagenicity+of+Acrylamide+and+Glycidamide+in+the+Testes+of+Big+Blue+Mice&rft.au=Wang%2C+Rui-Sheng%3BMcDaniel%2C+Lea+P%3BManjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BDoerge%2C+Daniel+R%3BMei%2C+Nan&rft.aulast=Wang&rft.aufirst=Rui-Sheng&rft.date=2010-01-01&rft.volume=117&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Mutation ER - TY - JOUR T1 - Scaling up the national methadone maintenance treatment program in China: achievements and challenges AN - 856764302; 14027409 AB - China's methadone maintenance treatment program was initiated in 2004 as a small pilot project in just eight sites. It has since expanded into a nationwide program encompassing more than 680 clinics covering 27 provinces and serving some 242 000 heroin users by the end of 2009. The agencies that were tasked with the program's expansion have been confronted with many challenges, including high drop-out rates, poor cooperation between local governing authorities and poor service quality at the counter. In spite of these difficulties, ongoing evaluation has suggested reductions in heroin use, risky injection practices and, importantly, criminal behaviours among clients, which has thus provided the impetus for further expansion. Clinic services have been extended to offer clients a range of ancillary services, including HIV, syphilis and hepatitis C testing, information, education and communication, psychosocial support services and referrals for treatment of HIV, tuberculosis and sexually transmitted diseases. Cooperation between health and public security officials has improved through regular meetings and dialogue. However, institutional capacity building is still needed to deliver sustainable and standardized services that will ultimately improve retention rates. This article documents the steps China made in overcoming the many barriers to success of its methadone program. These lessons might be useful for other countries in the region that are scaling-up their methadone programs. JF - International Journal of Epidemiology AU - Yin, Wenyuan AU - Hao, Yang AU - Sun, Xinhua AU - Gong, Xiuli AU - Li, Fang AU - Li, Jianhua AU - Rou, Keming AU - Sullivan, Sheena G AU - Wang, Changhe AU - Cao, Xiaobin AU - Luo, Wei AU - Wu, Zunyou AD - National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, Bureau for Disease Control and Prevention, Ministry of Health, People's Republic of China, Office of National Narcotics Control Committee, People's Republic of China, Department of Drug Safety and Inspection, State Food and Drug Administration, People's Republic of China, Yunnan Institute of Drug Abuse, China and Department of Epidemiology, University of California, Los Angeles, CA, USA Y1 - 2010 PY - 2010 DA - 2010 SP - ii29 EP - ii37 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 39 SN - 0300-5771, 0300-5771 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mycobacterium KW - Maintenance KW - carrying capacity KW - scaling KW - tuberculosis KW - Education KW - Communications KW - Human immunodeficiency virus KW - Treponema pallidum KW - Standards KW - China, People's Rep. KW - heroin KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856764302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Epidemiology&rft.atitle=Scaling+up+the+national+methadone+maintenance+treatment+program+in+China%3A+achievements+and+challenges&rft.au=Yin%2C+Wenyuan%3BHao%2C+Yang%3BSun%2C+Xinhua%3BGong%2C+Xiuli%3BLi%2C+Fang%3BLi%2C+Jianhua%3BRou%2C+Keming%3BSullivan%2C+Sheena+G%3BWang%2C+Changhe%3BCao%2C+Xiaobin%3BLuo%2C+Wei%3BWu%2C+Zunyou&rft.aulast=Yin&rft.aufirst=Wenyuan&rft.date=2010-01-01&rft.volume=39&rft.issue=&rft.spage=ii29&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Last updated - 2013-09-09 N1 - SubjectsTermNotLitGenreText - tuberculosis; Education; Communications; Human immunodeficiency virus; Standards; carrying capacity; Maintenance; heroin; scaling; Mycobacterium; Treponema pallidum; China, People's Rep. ER - TY - JOUR T1 - Algorithmic approach to pushback design based on stochastic programming: method, application and comparisons AN - 853486878; 14144228 AB - Pushback design affects the way a mineral deposit is extracted. It defines where the operation begins, the contour of the ultimate pit, and how to reach such ultimate contour. Therefore, different pushback designs lead to differences in the net present value (NPV) of a project. It is important to find the optimal pushback design which maximises the NPV. Conventional approaches to designing pushbacks lead to not meeting production targets and NPV forecasts. This is mainly due to the lack of integrating uncertainty into the process. Recent efforts have shown that the integration of uncertainty into production scheduling results in NPV increases in the order of similar to 25%. The purpose of this research is to make use of a stochastic integer programming model to integrate uncertainty into the process of pushback design. The approach is tested on porphyry copper deposit. Results show the sensitivity of the NPV to the design of starting and intermediate pushbacks, as well as the pushback design at the bottom of the pit. The new approach yielded an increment of similar to 30% in the NPV when compared to the conventional approach. The differences reported are due to different scheduling patterns, the waste mining rate and an extension of the pit limits which yielded an extra similar to 5500 t of metal. JF - Mining Technology (Transactions of the Institution of Mining and Metallurgy, Section A) AU - Consuegra, FRAlbor AU - Dimitrakopoulos, R AD - COSMO - Stochastic Mine Planning Laboratory, Department of Mining and Materials Engineering, McGill University, FDA Building, 3450 University Street, Montreal, Que. H3A 2A7, Canada Y1 - 2010 PY - 2010 DA - 2010 SP - 88 EP - 101 PB - Maney Publishing Ltd., Suite 1C, Joseph's Well Leeds LS3 1AB UK VL - 119 IS - 2 SN - 0371-7844, 0371-7844 KW - Pollution Abstracts KW - MINE PRODUCTION SCHEDULING KW - STOCHASTIC OPTIMISATION KW - PUSHBACK DESIGN KW - PIT LIMITS KW - Metals KW - Sensitivity KW - Copper KW - Mining KW - Minerals KW - Design KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/853486878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Technology+%28Transactions+of+the+Institution+of+Mining+and+Metallurgy%2C+Section+A%29&rft.atitle=Algorithmic+approach+to+pushback+design+based+on+stochastic+programming%3A+method%2C+application+and+comparisons&rft.au=Consuegra%2C+FRAlbor%3BDimitrakopoulos%2C+R&rft.aulast=Consuegra&rft.aufirst=FRAlbor&rft.date=2010-01-01&rft.volume=119&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Mining+Technology+%28Transactions+of+the+Institution+of+Mining+and+Metallurgy%2C+Section+A%29&rft.issn=03717844&rft_id=info:doi/10.1179%2F037178410X12780655704761 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Sensitivity; Metals; Mining; Copper; Minerals; Design DO - http://dx.doi.org/10.1179/037178410X12780655704761 ER - TY - JOUR T1 - Analytical Method Development and Monitoring of Residual Solvents in Dietary Supplements AN - 851462667; 14091972 AB - Residual solvents in foods are defined as organic volatile chemicals used or produced in manufacturing of extracts or additives, or functional foods. The solvents are not completely eliminated by practical manufacturing techniques and they also may become contaminated by solvents from packing, transportation or storage in warehouses. Because residual solvents have no nutritional value but may be hazardous to human health, there is a need to remove them from the final products or reduce their amounts to below acceptable levels. The purpose of this study was to develop and evaluate an analytical method for the screening of residual solvents in health functional foods. Furthermore, the aim of this study was to constitute a reasonable management system based on the current state of the market and case studies of foreign countries. Eleven volatile solvents such as MeOH, EtOH, trichloroethylene and hexane were separated depending on their column properties, temp, and time using Gas Chromatography (GC). After determining the GC conditions, a sample preparation method using HSS (Head Space Sampling) was developed. From the results, a method for analyzing residual solvents in health functional foods was developed considering matrix effect and interference from the sample obtained from the solution of solvents-free health functional foods spiked with 11 standards solutions. Validation test using the developed GC/HSS/MS (Mass Spectrometry) method was followed by tests for precision, accuracy, recovery, linearity and adequate sensitivity. Finally, examination of 104 samples grouped in suits was performed by the developed HSS/GC/MS for screening the solvents. The 11 solvents were isolated from health functional foods based on vapor pressure difference, and followed by separation within 15 minutes in a single run. The limt of detection (LOD), limit of quantification (LOQ), recovery and coefficient of variation (C.V.) of these compounds determined by the HSS/GC/MS were found to be 0.1 pg/mL, 0.1-125 pg/g, 51.0-104.6%, and less than 15%, respectively. Using the developed HSS/GC/MS method, residual solvent from 16 out of 104 health functional products were detected as a EtOH. This method therefore seems to be a valuable extension of analytical method for the identification of residual solvents in health functional food. JF - Korean Journal of Food Science and Technology AU - Lee, H-M AU - Shin, J-E AU - Jang, Y-M AU - Kim, H-Y AU - Kim, M AD - Hazard Substance Analysis Division, Center for Food and Drug Inspection, Gyeongin Regional Korea Food and Drug Administration, Incheon 402-835, Korea, lhm9904@kfda.go.kr Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 390 EP - 397 PB - Korean Society of Food Science and Technology, The Korea Science and Technology Center #605 635-4 Yeogsam-dong, Kangnam-ku Seoul 135-703 Korea, Republic of VL - 42 IS - 4 SN - 0367-6293, 0367-6293 KW - Toxicology Abstracts KW - Head KW - Food KW - Solvents KW - Packing KW - Mass spectroscopy KW - Food additives KW - Vapors KW - Volatiles KW - Gas chromatography KW - Dietary supplements KW - Headspace KW - Trichloroethylene KW - Sampling KW - Pressure KW - n-Hexane KW - Ethanol KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851462667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Analytical+Method+Development+and+Monitoring+of+Residual+Solvents+in+Dietary+Supplements&rft.au=Lee%2C+H-M%3BShin%2C+J-E%3BJang%2C+Y-M%3BKim%2C+H-Y%3BKim%2C+M&rft.aulast=Lee&rft.aufirst=H-M&rft.date=2010-01-01&rft.volume=42&rft.issue=4&rft.spage=390&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Head; Food; Solvents; Packing; Mass spectroscopy; Vapors; Food additives; Gas chromatography; Volatiles; Dietary supplements; Headspace; Sampling; Trichloroethylene; Pressure; n-Hexane; Ethanol ER - TY - JOUR T1 - Monitoring Methylmercury in Abyssal Fish AN - 851462403; 14091971 AB - The aim of this study was to determine the methylmercury (MeHg) levels in abyssal fish species. The MeHg in the fishes was extracted with hydrochloric acid and toluene and then purified using an L-cysteine solution. The extract was analyzed with a gas chromatography-electron capture detector (GC- mu ECD) with a thermon Hg-capillary column. The detection limit and the recovery of the method were 0.002 and 84.2-98.5% (mean, 93.4%), respectively. The MeHg content in 492 abyssal fishes ranged from 0.037 to 2.009 mg/kg. The levels of MeHg [range, mg/kg (mean)] were significantly dependent on fish species and presented as the following; 0.157-2.009 (0.546) in Scalloped hammerhead shark, 0.211-0.878 (0.501) in Blue shark, 0.121-0.993 (0.482) in Spiny dogfish, 0.243-0.658 (0.397) in Salmon shark, 0.074-1.958 (0.353) in Blacktip shark, 0.038-0.807 (0.302) in Southern hake, 0.099-0.511 (0.300) in Scorpion fish, and 0.037-0.133 (0.067) in Ling. The monitoring results showed that the estimated weekly intake of MeHg from sharks, Southern hake, and Ling were lower than the provisional tolerable weekly intake recommended by the Joint FAO/WHO expert committee on food additives. JF - Korean Journal of Food Science and Technology AU - Kim, S-C AU - Jang, J-W AU - Kim, H-A AU - Lee, S-H AU - Jung, Y-J AU - Kim, J-Y AU - Ahn, J-H AU - Park, E-H AU - Ko, Y-S AU - Kim, D-S AU - Kim, S-Y AU - Jang, Y-M AU - Kang, C-S AD - Imported Food Analysis Division, Center for Food and Drug Analysis, Busan Regional Korea Food and Drug Administration, Busan 608-829, Korea, sckim77@kfda.go.kr Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 383 EP - 389 PB - Korean Society of Food Science and Technology, The Korea Science and Technology Center #605 635-4 Yeogsam-dong, Kangnam-ku Seoul 135-703 Korea, Republic of VL - 42 IS - 4 SN - 0367-6293, 0367-6293 KW - ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; Toxicology Abstracts KW - Marine fish KW - Marine KW - Methyl mercury KW - Food additives KW - Toluene KW - Anadromous species KW - Dimethylmercury KW - Salmonidae KW - Hydrochloric acid KW - Joints KW - Q1 08422:Environmental effects KW - O 1050:Vertebrates, Urochordates and Cephalochordates KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/851462403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Monitoring+Methylmercury+in+Abyssal+Fish&rft.au=Kim%2C+S-C%3BJang%2C+J-W%3BKim%2C+H-A%3BLee%2C+S-H%3BJung%2C+Y-J%3BKim%2C+J-Y%3BAhn%2C+J-H%3BPark%2C+E-H%3BKo%2C+Y-S%3BKim%2C+D-S%3BKim%2C+S-Y%3BJang%2C+Y-M%3BKang%2C+C-S&rft.aulast=Kim&rft.aufirst=S-C&rft.date=2010-01-01&rft.volume=42&rft.issue=4&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Marine fish; Methyl mercury; Food additives; Anadromous species; Toluene; Dimethylmercury; Hydrochloric acid; Joints; Salmonidae; Marine ER - TY - JOUR T1 - Free fatty acids profile of the fetal brain and the plasma, liver, brain and kidneys of pregnant rats treated with sodium arsenite at mid-organogenesis AN - 847438180; 13919371 AB - Free fatty acids (FFAs) are known to be markers of cellular membrane degradation through lipid peroxidation and are substrates for the production of reactive oxygen species (ROS). Oxidative stress, due to overproduction of ROS, may facilitate cellular insult by various toxicants. The ability of the rat conceptus to respond to toxic stress may be critical for normal development. In this study, the effects of the environmental toxicant sodium arsenite (NaAsO2) on FFAs were investigated after administering a single oral dose, in water and in a lipid medium, to pregnant rats on gestational day (GD) 10, a time point at mid-organogenesis. NaAsO 2 was administered in deionized water (AsH2O) or in half and half dairy cream (AsHH) at a dose of 41 mg sodium arsenite (NaAsO 2)/kg body weight. Control animals were treated with either dairy cream (HH) or deionized water (H2O). The animals were sacrificed on GD 20. The fetal brain and the maternal liver, brain, plasma and kidneys were harvested. The FFAs were extracted and analyzed by gas chromatography. In the liver, there was an increase of myristic acid (1200%), myristoleic acid (174%), palmitic acid (47%), elaidic acid (456%), oleic acid (165%) and docosahexaenoic acid (224%) in the AsH2O group as compared to the AsHH group. Oleic acid and arachidonic acid were increased by 192% and 900%, respectively, in the AsH2O group as compared to the H 2O group, and myristic acid was decreased by 90% in the AsHH group as compared to the HH group. In the maternal brain, myristoleic acid was decreased by 91% in the AsH2O group as compared to the H2O group, and DHA increased by 148% in the AsHH group as compared to the HH group. In the fetal brain, myristic and stearic acids were decreased by 87% and 89%, respectively, in the AsH2O group as compared to the AsHH group. Myristic, stearic and arachidonic acids were increased by 411%, 265%, and 144%, respectively, in the AsHH group as compared to the HH group. There was no effect on the fatty acids concentrations in the kidney or plasma as compared to controls. This study shows that NaAsO2 produced a differential effect on the fatty acid profiles in rats. Further investigation is needed to elucidate the role of fatty acids in differential signaling and regulation by either the palmitoylation or myristoylation process of cellular functions in these target organs. JF - Toxicology and Industrial Health AU - Ross, Ivan A AU - Boyle, Thomas AU - Johnson, Widmark D AU - Sprando, Robert L AU - O'Donnell, Michael W AU - Ruggles, Dennis AU - Kim, Chung S AD - Center for Food Safety and Applied Nutrition, Division of Toxicology, Office of Applied Research and Safety Assessment, Laurel, MD, USA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Office of Applied Research and Safety Assessment, Laurel, MD, USA. Center for Food Safety and Applied Nutrition, Division of Toxicology, Office of Applied Research and Safety Assessment, Laurel, MD, USA. Center for Food Safety and Applied Nutrition, Division of Toxicology, Office of Applied Research and Safety Assessment, Laurel, MD, USA. Biostatistics Branch, Division of Public Health and Biostatistics, Office of Food Defense, Communication and Emergency Response, Muirkirk Road, Laurel, MD, USA. Biostatistics Branch, Division of Public Health and Biostatistics, Office of Food Defense, Communication and Emergency Response, Muirkirk Road, Laurel, MD, USA. Center for Food Safety and Applied Nutrition, Division of Toxicology, Office of Applied Research and Safety Assessment, Laurel, rossivan@msn.com Y1 - 2010 PY - 2010 DA - 2010 SP - 657 EP - 666 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 26 IS - 10 SN - 0748-2337, 0748-2337 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Stearic acid KW - Sodium arsenite KW - Toxicants KW - Brain KW - Arachidonic acid KW - myristoylation KW - Fetuses KW - Lipid peroxidation KW - Pregnancy KW - Dairies KW - Docosahexaenoic acid KW - palmitoylation KW - Reactive oxygen species KW - Body weight KW - Oxidative stress KW - Gas chromatography KW - Palmitic acid KW - Membrane degradation KW - Cream KW - Liver KW - Kidney KW - Fatty acids KW - Oleic acid KW - N3 11028:Neuropharmacology & toxicology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/847438180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Free+fatty+acids+profile+of+the+fetal+brain+and+the+plasma%2C+liver%2C+brain+and+kidneys+of+pregnant+rats+treated+with+sodium+arsenite+at+mid-organogenesis&rft.au=Ross%2C+Ivan+A%3BBoyle%2C+Thomas%3BJohnson%2C+Widmark+D%3BSprando%2C+Robert+L%3BO%27Donnell%2C+Michael+W%3BRuggles%2C+Dennis%3BKim%2C+Chung+S&rft.aulast=Ross&rft.aufirst=Ivan&rft.date=2010-01-01&rft.volume=26&rft.issue=10&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Stearic acid; Sodium arsenite; Toxicants; Brain; Arachidonic acid; myristoylation; Lipid peroxidation; Fetuses; Pregnancy; Docosahexaenoic acid; Dairies; palmitoylation; Body weight; Reactive oxygen species; Gas chromatography; Oxidative stress; Membrane degradation; Palmitic acid; Fatty acids; Kidney; Liver; Cream; Oleic acid ER - TY - JOUR T1 - Medical Technology and the U.S. Healthcare System: Is This the Road to Abilene? AN - 837451778; 2010-668418 AB - The conventional wisdom that Americans are unwilling to discuss limits to healthcare resources or tolerate any restrictions on treatment choices presents a formidable barrier to implementing policies that would reduce healthcare cost growth. Typical explanations for the conventional wisdom are plentiful, but not entirely useful in providing guidance for appropriate policy responses. In this paper, we analyze an organizational theory known as the Abilene Paradox to explain the lack of public engagement and the paucity of research concerning public values and preferences on difficult healthcare issues such as the use of medical technology. The analysis suggests that one strategy for improving policymaking would be to expand on recent research efforts concerning public participation in decisions about medical technology. These efforts demonstrate that when structured, deliberative methods are employed, members of the public are both willing and able to engage as social decision makers for allocating limited resources. Tables, References. Adapted from the source document. JF - World Medical and Health Policy AU - Sheingold, Steven AU - Sheingold, Brenda Helen AD - Office of the Assistant Secretary for Planning and Evaluation (ASPE), U.S. Department of Health and Human Services Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 85 EP - 109 PB - Berkeley Electronic Press, CA VL - 2 IS - 2 SN - 1948-4682, 1948-4682 KW - Health conditions and policy - Health and health policy KW - Science and technology policy - Technology and technology policy KW - Social conditions and policy - Community life and organization KW - health policy, medical technology, rationing KW - United States KW - Citizen participation KW - Health policy KW - Medical technology KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/837451778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+Medical+and+Health+Policy&rft.atitle=Medical+Technology+and+the+U.S.+Healthcare+System%3A+Is+This+the+Road+to+Abilene%3F&rft.au=Sheingold%2C+Steven%3BSheingold%2C+Brenda+Helen&rft.aulast=Sheingold&rft.aufirst=Steven&rft.date=2010-01-01&rft.volume=2&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=World+Medical+and+Health+Policy&rft.issn=19484682&rft_id=info:doi/10.2202%2F1948-4682.1075 L2 - http://www.psocommons.org/wmhp LA - English DB - PAIS Index N1 - Date revised - 2011-01-10 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Medical technology; Citizen participation; United States DO - http://dx.doi.org/10.2202/1948-4682.1075 ER - TY - JOUR T1 - Could It Be Asthma? Using Social Marketing Strategies to Increase Parent and Caregiver Knowledge of Asthma Symptoms in Children in a Rural Community AN - 822497579; 201031324 AB - Many parents and caregivers do not recognize the symptoms of asthma in children, and consequently children may not receive the appropriate diagnosis and treatment for this potentially fatal disease. This article describes how Steps to a HealthierNY used social marketing strategies to design a media campaign called "Could It Be Asthma?" to educate parents and caregivers about the symptoms of asthma. The campaign used television advertising, brochures, and posters to educate parents and caregivers in rural Jefferson County, New York, about asthma symptoms. The campaign ran in March and April 2005. A follow-up survey was conducted among 756 parents and caregivers in collaboration with four local pediatricians' offices. Results showed that approximately 60% of participants were familiar with "Could It Be Asthma?" Of those participants, approximately 68% indicated that the ads had a positive impact and 46% indicated that they had learned the symptoms of asthma. The campaign and survey were repeated in the fall of 2005. Results were consistent, with a significant increase in the percentage of people who were familiar with the campaign. This social marketing campaign was successful in reaching parents in a rural community with important educational messages; similar strategies should be considered in educating the public about asthma and other health issues. Adapted from the source document. [Reprinted by permission of Sage Publications Inc., copyright holder.] JF - Health Promotion Practice AU - Briones, Kristi AU - Lustik, Faith AU - LaLone, Joel AD - Jefferson County Public Health Service, Watertown, NY kristib@co.jefferson.ny.us Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 859 EP - 866 PB - Sage Publications, Thousand Oaks CA VL - 11 IS - 6 SN - 1524-8399, 1524-8399 KW - Social marketing KW - Symptoms KW - Campaigns KW - Asthma KW - Parents KW - Carers KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822497579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Promotion+Practice&rft.atitle=Could+It+Be+Asthma%3F+Using+Social+Marketing+Strategies+to+Increase+Parent+and+Caregiver+Knowledge+of+Asthma+Symptoms+in+Children+in+a+Rural+Community&rft.au=Briones%2C+Kristi%3BLustik%2C+Faith%3BLaLone%2C+Joel&rft.aulast=Briones&rft.aufirst=Kristi&rft.date=2010-01-01&rft.volume=11&rft.issue=6&rft.spage=859&rft.isbn=&rft.btitle=&rft.title=Health+Promotion+Practice&rft.issn=15248399&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-12-16 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Asthma; Campaigns; Parents; Symptoms; Carers; Social marketing ER - TY - JOUR T1 - Approval summary: pemetrexed maintenance therapy of advanced/metastatic nonsquamous, non-small cell lung cancer (NSCLC). AN - 821737935; 21148615 AB - On July 2, 2009, the U.S. Food and Drug Administration approved pemetrexed injection (Alimta® Injection; Eli Lilly and Company, Indianapolis, IN) for maintenance treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer whose disease has not progressed after four cycles of platinum-based doublet induction chemotherapy. A double-blind study of pemetrexed plus best supportive care versus placebo plus best supportive care was conducted. Pemetrexed, 500 mg/m(2) i.v., was administered every 21 days until disease progression. Folic acid, vitamin B(12), and a corticosteroid were given to all study patients. There were 663 randomized patients (pemetrexed, 441; placebo, 222). Treatments were well balanced with respect to baseline disease characteristics and stratification factors. The median overall survival (OS) time for intent-to-treat (ITT) patients was 13.4 months for patients receiving pemetrexed and 10.6 months for those receiving placebo (hazard ratio [HR] 0.79; 95% confidence interval [CI], 0.65-0.95; p = .012). Median OS times were 15.5 months versus 10.3 months for patients with nonsquamous histologies receiving pemetrexed and placebo, respectively (HR, 0.70; 95% CI, 0.56-0.88). The median OS time in patients with squamous histology receiving pemetrexed was 9.9 months, versus 10.8 months for those receiving placebo (HR, 1.07; 95% CI, 0.77-1.50). A significantly longer progression-free survival interval for both the ITT and nonsquamous patient populations receiving pemetrexed maintenance therapy was also observed. The most common (>5%) adverse reactions in patients receiving pemetrexed were hematologic toxicity, an increase in hepatic enzymes, fatigue, gastrointestinal toxicity, sensory neuropathy, and skin rash. JF - The oncologist AU - Cohen, Martin H AU - Cortazar, Patricia AU - Justice, Robert AU - Pazdur, Richard AD - Office of Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993-0002, USA. martin.cohen@fda.hhs.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 1352 EP - 1358 VL - 15 IS - 12 KW - Antineoplastic Agents KW - 0 KW - Glutamates KW - Placebos KW - Pemetrexed KW - 04Q9AIZ7NO KW - Guanine KW - 5Z93L87A1R KW - Thymidylate Synthase KW - EC 2.1.1.45 KW - Index Medicus KW - United States KW - Adenocarcinoma, Bronchiolo-Alveolar -- drug therapy KW - Carcinoma, Large Cell -- drug therapy KW - Double-Blind Method KW - Neoplasm Staging KW - Humans KW - Adenocarcinoma -- pathology KW - Carcinoma, Large Cell -- pathology KW - Thymidylate Synthase -- antagonists & inhibitors KW - United States Food and Drug Administration KW - Adenocarcinoma, Bronchiolo-Alveolar -- pathology KW - Treatment Outcome KW - Middle Aged KW - Adenocarcinoma -- drug therapy KW - Female KW - Male KW - Drug Approval KW - Lung Neoplasms -- drug therapy KW - Guanine -- analogs & derivatives KW - Glutamates -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Guanine -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821737935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=Approval+summary%3A+pemetrexed+maintenance+therapy+of+advanced%2Fmetastatic+nonsquamous%2C+non-small+cell+lung+cancer+%28NSCLC%29.&rft.au=Cohen%2C+Martin+H%3BCortazar%2C+Patricia%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Cohen&rft.aufirst=Martin&rft.date=2010-01-01&rft.volume=15&rft.issue=12&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2010-0224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-04-26 N1 - Date created - 2010-12-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 2006 Oct 1;107(7):1589-96 [16955506] Lung Cancer. 2006 May;52(2):155-63 [16569462] Oncologist. 2007 Apr;12(4):451-64 [17470688] J Natl Cancer Inst Monogr. 2007;(37):27-30 [17951228] J Clin Oncol. 2007 Nov 10;25(32):5133-40 [17991933] J Clin Oncol. 2008 Jul 20;26(21):3543-51 [18506025] Oncologist. 2009 Mar;14(3):253-63 [19221167] Oncologist. 2009 Sep;14(9):930-5 [19737998] Oncology (Williston Park). 2009 Nov 30;23(13):1133-40 [20043461] Oncologist. 2010;15(1):3-5 [20086166] J Clin Oncol. 2001 Mar 1;19(5):1336-43 [11230476] J Clin Oncol. 2002 Mar 1;20(5):1335-43 [11870177] J Clin Oncol. 2002 Nov 1;20(21):4285-91 [12409326] Biochem Pharmacol. 2003 Aug 1;66(3):431-8 [12907242] J Clin Oncol. 2004 Jan 15;22(2):330-53 [14691125] J Clin Oncol. 2004 May 1;22(9):1589-97 [15117980] Cancer Treat Rep. 1982 Mar;66(3):439-49 [7060033] Lung Cancer. 2005 Feb;47(2):253-9 [15639724] Oncologist. 2005 Jun-Jul;10(6):363-8 [15967829] Cancer. 2006 Apr 1;106(7):1595-601 [16489621] Ann Oncol. 2006 Mar;17 Suppl 2:ii67-70 [16608989] N Engl J Med. 2006 Dec 14;355(24):2542-50 [17167137] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2010-0224 ER - TY - JOUR T1 - Pneumoconiosis among underground bituminous coal miners in the United States: is silicosis becoming more frequent? AN - 818831381; 13721357 AB - OBJECTIVES: Epidemiological reports since 2000 have documented increased prevalence and rapid progression of pneumoconiosis among underground coal miners in the United States. To investigate a possible role of silica exposure in the increase, we examined chest x-rays (CXRs) for specific abnormalities (r-type small opacities) known to be associated with silicosis lung pathology. METHODS: Underground coal miners are offered CXRs every 5 years. Abnormalities consistent with pneumoconiosis are recorded by National Institute for Occupational Safety and Health (NIOSH) B Readers using the International Labour Organization Classification of Radiographs of Pneumoconioses. CXRs from 1980 to 2008 of 90 973 participating miners were studied, focussing on reporting of r-type opacities (small rounded opacities 3-10 mm in diameter). Log binomial regression was used to calculate prevalence ratios adjusted for miner age and profusion category. RESULTS: Among miners from Kentucky, Virginia and West Virginia, the proportion of radiographs showing r-type opacities increased during the 1990s (prevalence ratio (PR) 2.5; 95% CI 1.7 to 3.7) and after 1999 (PR 4.1; 95% CI 3.0 to 5.6), compared to the 1980s (adjusted for profusion category and miner age). The prevalence of progressive massive fibrosis in 2000-2008 was also elevated compared to the 1980s (PR 4.4; 95% CI 3.1 to 6.3) and 1990s (PR 3.8; 95% CI 2.1 to 6.8) in miners from Kentucky, Virginia and West Virginia. CONCLUSIONS: The increasing prevalence of pneumoconiosis over the past decade and the change in the epidemiology and disease profile documented in this and other recent studies imply that US coal miners are being exposed to excessive amounts of respirable crystalline silica. JF - Occupational and Environmental Medicine AU - Laney, A Scott AU - Petsonk, Edward L AU - Attfield, Michael D AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 652 EP - 656 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR UK VL - 67 IS - 10 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Age KW - Pathology KW - Occupational safety KW - Pneumoconiosis KW - USA, Virginia KW - Coal KW - USA, West Virginia KW - USA, Kentucky KW - silica KW - Silicosis KW - classification KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/818831381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Pneumoconiosis+among+underground+bituminous+coal+miners+in+the+United+States%3A+is+silicosis+becoming+more+frequent%3F&rft.au=Laney%2C+A+Scott%3BPetsonk%2C+Edward+L%3BAttfield%2C+Michael+D&rft.aulast=Laney&rft.aufirst=A&rft.date=2010-01-01&rft.volume=67&rft.issue=10&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Age; Pathology; Silicosis; silica; Occupational safety; classification; Pneumoconiosis; Coal; Mining; USA, Kentucky; USA, Virginia; USA, West Virginia ER - TY - JOUR T1 - Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells AN - 807277175; 13844665 AB - The current report examines the interactions of silver nanoparticles (Ag-NPs) with the cerebral microvasculature to identify the involvement of proinflammatory mediators that can increase blood-brain barrier (BBB) permeability. Primary rat brain microvessel endothelial cells (rBMEC) were isolated from adult Sprague-Dawley rats for an in vitro BBB model. The Ag-NPs were characterized by transmission electron microscopy (TEM), dynamic light scattering, and laser Doppler velocimetry. The cellular accumulation, cytotoxicity (6.25-50 kg/cm3) and potential proinflammatory mediators (interleukin [IL]-1b, IL-2, tumor necrosis factor [TNF] a, and prostaglandin E2 [PGE2]) of Ag-NPs (25, 40, or 80 nm) were determined spectrophotometrically, cell proliferation assay (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxa n ilide) and ELISA. The results show Ag-NPs-induced cytotoxic responses at lower concentrations for 25 and 40 nm when compared with 80-nm Ag-NPs. The proinflammatory responses in this study demonstrate both Ag-NPs size and time-dependent profiles, with IL-1B preceding both TNF and PGE2 for 25 nm. However, larger Ag-NPs (40 and 80 nm) induced significant TNF responses at 4 and 8 h, with no observable PGE2 response. The increased fluorescein transport observed in this study clearly indicates size-dependent increases in BBB permeability correlated with the severity of immunotoxicity. Together, these data clearly demonstrate that larger Ag-NPs (80 nm) had significantly less effect on rBMEC, whereas the smaller particles induced significant effects on all the end points at lower concentrations and/or shorter times. Further, this study suggests that Ag-NPs may interact with the cerebral microvasculature producing a proinflammatory cascade, if left unchecked; these events may further induce brain inflammation and neurotoxicity. JF - Toxicological Sciences AU - Trickler, William J AU - Lantz, Susan M AU - Murdock, Richard C AU - Schrand, Amanda M AU - Robinson, Bonnie L AU - Newport, Glenn D AU - Schlager, John J AU - Oldenburg, Steven J AU - Paule, Merle G AU - Slikker, William AU - Hussain, Saber M AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079 Y1 - 2010 PY - 2010 DA - 2010 SP - 160 EP - 170 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK VL - 118 IS - 1 SN - 1096-6080, 1096-6080 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Animal models KW - Inflammation KW - X:24390 KW - N3:11007 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807277175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Silver+Nanoparticle+Induced+Blood-Brain+Barrier+Inflammation+and+Increased+Permeability+in+Primary+Rat+Brain+Microvessel+Endothelial+Cells&rft.au=Trickler%2C+William+J%3BLantz%2C+Susan+M%3BMurdock%2C+Richard+C%3BSchrand%2C+Amanda+M%3BRobinson%2C+Bonnie+L%3BNewport%2C+Glenn+D%3BSchlager%2C+John+J%3BOldenburg%2C+Steven+J%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BHussain%2C+Saber+M%3BAli%2C+Syed+F&rft.aulast=Trickler&rft.aufirst=William&rft.date=2010-01-01&rft.volume=118&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Inflammation ER - TY - JOUR T1 - Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 Molar Ratio and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 759315786; 13720125 AB - BACKGROUND: Experimental evidence suggests that an overexpression of insulin-like growth factor (IGF)-I is implicated in human pancreatic tumors. Increased IGF-II and decreased IGF binding protein (IGFBP)-3 serum concentrations have been linked to a number of other cancers. METHODS: We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial cohort of men and women 55 to 74 years of age at baseline to test whether prediagnostic circulating IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 molar ratio concentrations were associated with exocrine pancreatic cancer risk. Between 1994 and 2006, 187 incident cases of pancreatic adenocarcinoma occurred (follow-up of up to 11.7 years). Two controls (n = 374), who were alive at the time the case was diagnosed, were selected for each case and matched by age, race, sex, and date of blood draw. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) with the use of conditional logistic regression, adjusting for smoking. RESULTS: IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly associated with pancreatic cancer (highest compared with lowest quartile: OR, 1.58; 95% CI, 0.91-2.76; and P-trend = 0.25; OR, 0.86; 95% CI, 0.49-1.50; and P-trend = 0.31; and OR, 0.88; 95% CI, 0.51-1.51; and P-trend = 0.47, respectively). However, a significant positive trend was observed with high IGF-I/IGFBP-3 molar ratio levels (highest compared with lowest quartile: OR, 1.54; 95% CI, 0.89-2.66; P-trend = 0.04). CONCLUSION: A higher IGF-I/IGFBP-3 molar ratio represents increased free IGF-I, which may be a risk factor for pancreatic cancer. IMPACT: Our results highlight the importance of this biomarker for further investigation in large prospective cohort studies and pooled analysis with other prospective cohorts. Cancer Epidemiol Biomarkers Prev; 19(9); 2298-306. [copy ]2010 AACR. JF - Cancer Epidemiology, Biomarkers & Prevention AU - Douglas, Jason B AU - Silverman, Debra T AU - Pollak, Michael N AU - Tao, Yuzhen AU - Soliman, Amr S AU - Stolzenberg-Solomon, Rachael Z AD - Authors' Affiliations: Nutritional Epidemiology Branch and Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland Y1 - 2010 PY - 2010 DA - 2010 SP - 2298 EP - 2306 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA VL - 19 IS - 9 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - pancreatic cancer KW - Age KW - ovarian carcinoma KW - tumors KW - Cancer KW - Lung KW - Proteins KW - growth factors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759315786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+IGF-I%2C+IGF-II%2C+IGFBP-3%2C+and+IGF-I%2FIGFBP-3+Molar+Ratio+and+Risk+of+Pancreatic+Cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Douglas%2C+Jason+B%3BSilverman%2C+Debra+T%3BPollak%2C+Michael+N%3BTao%2C+Yuzhen%3BSoliman%2C+Amr+S%3BStolzenberg-Solomon%2C+Rachael+Z&rft.aulast=Douglas&rft.aufirst=Jason&rft.date=2010-01-01&rft.volume=19&rft.issue=9&rft.spage=2298&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Bioindicators; Age; pancreatic cancer; Lung; ovarian carcinoma; Proteins; tumors; growth factors; Cancer ER - TY - JOUR T1 - Developmental continuity and stability of emotional availability in the family: Two ages and two genders in child-mother dyads from two regions in three countries AN - 758108554; 201027565 AB - This study employs an intra-national and cross-national, prospective, and longitudinal design to examine age, gender, region, and country variation in group mean-level continuity and individual-differences stability of emotional availability in child-mother dyads. Altogether, 220 Argentine, Italian, and US American metropolitan and rural residence mothers and their daughters and sons were observed at home when children were five and 20 months of age. Similar patterns of continuity and discontinuity of emotional availability from five to 20 months were observed across regions and countries, but not between genders. Stability of emotional availability from five to 20 months was moderate and similar across genders, regions, and countries. Universal and gender-specific developmental processes in child-mother emotional availability as revealed in intra-national and cross-national study are discussed. Adapted from the source document. JF - International Journal of Behavioral Development AU - Bornstein, Marc H AU - Suwalsky, Joan T.D. AU - Putnick, Diane L AU - Gini, Motti AU - Venuti, Paola AU - de Falco, Simona AU - Heslington, Marianne AU - Zingman de Galperin, Celia AD - Child and Family Research Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, USA Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 385 EP - 397 PB - Sage Publications, Thousand Oaks, CA VL - 34 IS - 5 SN - 0165-0254, 0165-0254 KW - Sons KW - Developmental processes KW - Daughters KW - Discontinuity KW - Gender KW - Rural communities KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/758108554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=Developmental+continuity+and+stability+of+emotional+availability+in+the+family%3A+Two+ages+and+two+genders+in+child-mother+dyads+from+two+regions+in+three+countries&rft.au=Bornstein%2C+Marc+H%3BSuwalsky%2C+Joan+T.D.%3BPutnick%2C+Diane+L%3BGini%2C+Motti%3BVenuti%2C+Paola%3Bde+Falco%2C+Simona%3BHeslington%2C+Marianne%3BZingman+de+Galperin%2C+Celia&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2010-01-01&rft.volume=34&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Gender; Discontinuity; Daughters; Sons; Developmental processes; Rural communities ER - TY - JOUR T1 - Research on the implementation of preschool intervention programs: Learning by doing AN - 754136321; 201021212 AB - Abstract not available. [Copyright Elsevier B.V.] JF - Early Childhood Research Quarterly AU - Griffin, James A AD - Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services, United States james.griffin@nih.gov Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 267 EP - 269 PB - Elsevier Ltd, The Netherlands VL - 25 IS - 3 SN - 0885-2006, 0885-2006 KW - Implementation research Early intervention School readiness KW - Learning KW - Early intervention programmes KW - Preschools KW - School readiness KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754136321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+Childhood+Research+Quarterly&rft.atitle=Research+on+the+implementation+of+preschool+intervention+programs%3A+Learning+by+doing&rft.au=Griffin%2C+James+A&rft.aulast=Griffin&rft.aufirst=James&rft.date=2010-01-01&rft.volume=25&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Early+Childhood+Research+Quarterly&rft.issn=08852006&rft_id=info:doi/10.1016%2Fj.ecresq.2010.03.004 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-12 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Learning; Preschools; Early intervention programmes; School readiness DO - http://dx.doi.org/10.1016/j.ecresq.2010.03.004 ER - TY - JOUR T1 - A practical biomechanical model of the index finger simulating the kinematics of the muscle/tendon excursions AN - 753679772; 13240516 AB - Biomechanical models of the hand and fingers are useful tools for hand surgeons to improve surgical procedures and for biomedical researchers to explore the mechanical loading in the musculoskeletal system that cannot be easily measured in vivo. The purpose of the present study was to develop a realistic index finger model for solving practical problems. The model includes the meshes of four bony sections (distal, middle, proximal and metacarpal bones) obtained via micro-CT scans. The tendon attachment sites are adopted from the normative finger model. A total of seven tendon/muscles are included in the model. The predicted tendon excursions and moment arms were compared with published experimental data. One of the advantages of the current approach over previous studies is that the current model has been developed on a platform of a commercial software package, such that researchers can apply it as a universal tool for practical problems. JF - Bio-Medical Materials and Engineering AU - Wu, John Z AU - An, Kai-Nan AU - Cutlip, Robert G AU - Dong, Ren G AD - National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 89 EP - 97 PB - IOS Press, 5795-G Burke Centre Pkwy Burke VA 22015 USA VL - 20 IS - 2 SN - 0959-2989, 0959-2989 KW - Biotechnology and Bioengineering Abstracts KW - Index finger KW - kinematics KW - muscletendon excursion KW - moment arm KW - simulations KW - Mechanical loading KW - Kinematics KW - Data processing KW - Muscles KW - Hand KW - Finger KW - Models KW - Bone KW - Computer programs KW - software KW - Metacarpal KW - Musculoskeletal system KW - Computed tomography KW - Tendons KW - Mechanical properties KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/753679772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bio-Medical+Materials+and+Engineering&rft.atitle=A+practical+biomechanical+model+of+the+index+finger+simulating+the+kinematics+of+the+muscle%2Ftendon+excursions&rft.au=Wu%2C+John+Z%3BAn%2C+Kai-Nan%3BCutlip%2C+Robert+G%3BDong%2C+Ren+G&rft.aulast=Wu&rft.aufirst=John&rft.date=2010-01-01&rft.volume=20&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Bio-Medical+Materials+and+Engineering&rft.issn=09592989&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mechanical loading; Kinematics; Data processing; Muscles; Hand; Models; Finger; Bone; Computer programs; software; Musculoskeletal system; Metacarpal; Computed tomography; Tendons; Mechanical properties ER - TY - JOUR T1 - Development of a retrospective job exposure matrix for PCB-exposed workers in capacitor manufacturing. AN - 748941948; 20467200 AB - Polychlorinated biphenyls (PCBs) are considered probable human carcinogens by the International Agency for Research on Cancer and one congener, PCB126, has been rated as a known human carcinogen. A period-specific job exposure matrix (JEM) was developed for former PCB-exposed capacitor manufacturing workers (n=12,605) (1938-1977). A detailed exposure assessment for this plant was based on a number of exposure determinants (proximity, degree of contact with PCBs, temperature, ventilation, process control, job mobility). The intensity and frequency of PCB exposures by job for both inhalation and dermal exposures, and additional chemical exposures were reviewed. The JEM was developed in nine steps: (1) all unique jobs (n=1,684) were assessed using (2) defined PCB exposure determinants; (3) the exposure determinants were used to develop exposure profiles; (4) similar exposure profiles were combined into categories having similar PCB exposures; (5) qualitative intensity (high-medium-low-baseline) and frequency (continuous-intermittent) ratings were developed, and (6) used to qualitatively rate inhalation and dermal exposure separately for each category; (7) quantitative intensity ratings based on available air concentrations were developed for inhalation and dermal exposures based on equal importance of both routes of exposure; (8) adjustments were made for overall exposure, and (9) for each category the product of intensity and frequency was calculated, and exposure in the earlier era was weighted. A period-specific JEM modified for two eras of stable PCB exposure conditions. These exposure estimates, derived from a systematic and rigorous use of the exposure determinant data, lead to cumulative PCB exposure-response relationships in the epidemiological cancer mortality and incidence studies of this cohort. JF - Journal of occupational health AU - Hopf, Nancy B AU - Waters, Martha A AU - Ruder, Avima M AU - Prince, Mary M AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluation and Field Studies, Industry-wide Studies Branch, USA. akyarb@uab.edu Y1 - 2010 PY - 2010 DA - 2010 SP - 199 EP - 208 VL - 52 IS - 4 KW - Environmental Pollutants KW - 0 KW - Estrogen Antagonists KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - 3,4,5,3',4'-pentachlorobiphenyl KW - TSH69IA9XF KW - Index Medicus KW - Estrogen Antagonists -- poisoning KW - Dose-Response Relationship, Drug KW - Humans KW - Retrospective Studies KW - Environmental Pollutants -- poisoning KW - Massachusetts -- epidemiology KW - Epidemiologic Research Design KW - Male KW - Female KW - Occupational Exposure -- statistics & numerical data KW - Polychlorinated Biphenyls -- poisoning KW - Occupational Diseases -- epidemiology KW - Occupational Diseases -- chemically induced KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/748941948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+health&rft.atitle=Development+of+a+retrospective+job+exposure+matrix+for+PCB-exposed+workers+in+capacitor+manufacturing.&rft.au=Hopf%2C+Nancy+B%3BWaters%2C+Martha+A%3BRuder%2C+Avima+M%3BPrince%2C+Mary+M&rft.aulast=Hopf&rft.aufirst=Nancy&rft.date=2010-01-01&rft.volume=52&rft.issue=4&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+health&rft.issn=1348-9585&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-12-17 N1 - Date created - 2010-08-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer Risk Assessment Approaches at the FDA/CDER: Is the Era of the 2-Year Bioassay Drawing to a Close? AN - 746233016; 13115609 AB - Determining the carcinogenic potential of materials to which humans have significant exposures is an important, complex, and imperfect exercise. Not only are the methods for such determinations protracted and expensive and use large numbers of animals, extrapolation of data from such studies to human risk is imprecise. With improved understanding of oncogene activation and tumor suppressor gene inactivation, a number of animal models have been developed to dramatically reduce latency for chemically induced cancers and has led to the development and use of shorter carcinogenicity assays. Recent studies by a number of investigators suggest that specific gene signature patterns seen after short-term exposure of rats to test chemicals can predict long-term outcomes in cancer bioassays with relatively high accuracy. In addition, a recent survey performed by PhRMA member companies examined two hundred drug years to determine whether histological biomarkers seen at the end of a six- or twelve-month toxicology study in rats can predict the outcome of a two-year carcinogenicity study. With only a handful of exceptions, chronic studies appear capable of predicting effects at the end of two years with good accuracy. It is hoped that the combination of results from transgenic mouse assays and six-month rat studies will soon supplant the need for most two-year bioassays. JF - Toxicologic Pathology AU - Jacobson-Kram, David AD - Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA, david.jacobsonkram@fda.hhs.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 169 EP - 170 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 38 IS - 1 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Risk assessment KW - Tumor suppressor genes KW - Data processing KW - Oncogenes KW - Carcinogenicity KW - Animal models KW - Transgenic mice KW - biomarkers KW - Cancer KW - Physical training KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746233016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Cancer+Risk+Assessment+Approaches+at+the+FDA%2FCDER%3A+Is+the+Era+of+the+2-Year+Bioassay+Drawing+to+a+Close%3F&rft.au=Jacobson-Kram%2C+David&rft.aulast=Jacobson-Kram&rft.aufirst=David&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623309351892 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Tumor suppressor genes; Oncogenes; Data processing; Carcinogenicity; Animal models; Transgenic mice; biomarkers; Cancer; Physical training DO - http://dx.doi.org/10.1177/0192623309351892 ER - TY - JOUR T1 - Shape Analysis of 3D Head Scan Data for U.S. Respirator Users AN - 746225244; 12951138 AB - In 2003, the National Institute for Occupational Safety and Health (NIOSH) conducted a head-and-face anthropometric survey of diverse, civilian respirator users. Of the 3,997 subjects measured using traditional anthropometric techniques, surface scans and 26 three-dimensional (3D) landmark locations were collected for 947 subjects. The objective of this study was to report the size and shape variation of the survey participants using the 3D data. Generalized Procrustes Analysis (GPA) was conducted to standardize configurations of landmarks associated with individuals into a common coordinate system. The superimposed coordinates for each individual were used as commensurate variables that describe individual shape and were analyzed using Principal Component Analysis (PCA) to identify population variation. The first four principal components (PC) account for 49% of the total sample variation. The first PC indicates that overall size is an important component of facial variability. The second PC accounts for long and narrow or short and wide faces. Longer narrow orbits versus shorter wider orbits can be described by PC3, and PC4 represents variation in the degree of ortho/prognathism. Geometric Morphometrics provides a detailed and interpretable assessment of morphological variation that may be useful in assessing respirators and devising new test and certification standards. JF - EURASIP Journal on Advances in Signal Processing AU - Zhuang, Ziqing AU - Slice, Dennis E AU - Benson, Stacey AU - Lynch, Stephanie AU - Viscusi, Dennis J AD - National Personal Protective Technology Laboratory National Institute for Occupational Safety and Health Pittsburgh, PA 15236 Y1 - 2010 PY - 2010 DA - 2010 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 USA VL - 2010 KW - Health & Safety Science Abstracts KW - certification KW - USA KW - principal components analysis KW - Occupational safety KW - Respirators KW - Protective equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746225244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EURASIP+Journal+on+Advances+in+Signal+Processing&rft.atitle=Shape+Analysis+of+3D+Head+Scan+Data+for+U.S.+Respirator+Users&rft.au=Zhuang%2C+Ziqing%3BSlice%2C+Dennis+E%3BBenson%2C+Stacey%3BLynch%2C+Stephanie%3BViscusi%2C+Dennis+J&rft.aulast=Zhuang&rft.aufirst=Ziqing&rft.date=2010-01-01&rft.volume=2010&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=EURASIP+Journal+on+Advances+in+Signal+Processing&rft.issn=1687-6180&rft_id=info:doi/10.1155%2F2010%2F248954 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - certification; principal components analysis; Occupational safety; Respirators; Protective equipment; USA DO - http://dx.doi.org/10.1155/2010/248954 ER - TY - RPRT T1 - Construction Worker Dies When He Falls Through the Ceiling of a Refrigerator Freezer Unit AN - 746164735; 13109896 AB - A 47-year-old Hispanic construction worker died when he fell 13 feet through the ceiling of a refrigerator freezer unit to the concrete floor below. The victim had been on the job for two days and was working alone. He was in the process of checking the top of the refrigerator freezer unit for any loose debris at the time of the incident. The panels were supported by brackets attached to the freezer walls. The victim fell through a panel from which the wall bracket had been removed earlier. The victim was not wearing any fall protection. The CA/FACE investigator determined that in order to prevent future occurrences, employers, as part of their Injury and Illness Prevention Program (IIPP), should: Minimize the risk of employee falls during maintenance, disassembly, or demolition activities by performing a hazard analysis and ensuring fall prevention work practices are used. Provide task-specific safely training for employees who are at risk of falls when performing maintenance, disassembly, or demolition. JF - Construction Worker Dies When He Falls Through the Ceiling of a Refrigerator Freezer Unit. [np]. Jan 2010. AU - Anonymous Y1 - 2010/01// PY - 2010 DA - Jan 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Injuries KW - Training KW - Concrete KW - Maintenance KW - risk reduction KW - prevention KW - Construction industry KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Construction+Worker+Dies+When+He+Falls+Through+the+Ceiling+of+a+Refrigerator+Freezer+Unit&rft.title=Construction+Worker+Dies+When+He+Falls+Through+the+Ceiling+of+a+Refrigerator+Freezer+Unit&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Monitoring Total Mercury and Methylmercury in Mainly Consumed Aquatic Foods AN - 746164295; 13227288 AB - Total mercury and methylmercury concentrations were determined in 15 commonly consumed aquatic food species using total mercury analyzer and gas chromatography with electron capture detector. The mean total mercury and methylmercury concentrations (mg/kg) were 0.088 and 0.034 in mackerel, 0.061 and 0.016 in hair tail, 0.030 and 0.005 in yellow croaker, 0.032 and 0.008 in Alaska pollock, 0.059 and 0.023 in eastern catfish, 0.110 and 0.045 in snakehead, 0.030 and 0.011 in Japanese common squid, 0.026 and 0.009 in common octopus, 0.035 and 0.008 in swimming crab, 0.009 and not detected (ND) in oyster, 0.011 and ND in shortneck clam, 0.008 and ND in mussel, 0.018 and ND in sea mustard, 0.007 and ND in nori, and 0.019 and ND in sea tangle, respectively. The total weekly dietary intakes of total mercury and methylmercury were estimated, respectively, using food consumption data from diet surveys and the concentrations of total mercury and methylmercury from this study. They were 0.178 kg/kg body weight (b.w.)/week (3.57% of provisional tolerable weekly intake (PTWI)) and 0.052 kg/kg b.w./week (3.34% of PTWI) respectively, and all were within their respective PTWI set by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Therefore, considering that the main contributor to mercury intake in the diet is aquatic foods and that the 15 aquatic food species examined in this study are highly consumed, it is concluded that the mercury levels in the foods measured in this study do not present a concern for consumer health. JF - Korean Journal of Food Science and Technology AU - Joo, HJ AU - Noh, MJ AU - Yoo, J H AU - Jang, Y M AU - Park, J S AU - Kang, M H AU - Kim, M AD - Center for Food and Drug Analysis, Gyeongin Regional Korea Food and Drug Administration, Incheon 402-835, Korea, meehkim@korea.kr Y1 - 2010///0, PY - 2010 DA - 0, 2010 SP - 269 EP - 276 PB - Korean Society of Food Science and Technology, The Korea Science and Technology Center #605 635-4 Yeogsam-dong, Kangnam-ku Seoul 135-703 Korea, Republic of VL - 42 IS - 3 SN - 0367-6293, 0367-6293 KW - Oceanic Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Marine KW - INW, Japan KW - Methyl mercury KW - Decapoda KW - Chromatographic techniques KW - Brackish KW - INE, USA, Alaska KW - Freshwater KW - Kelps KW - Octopus KW - Marine fish KW - Food consumption KW - Food additives KW - Body weight KW - Scomber KW - Marine molluscs KW - Mercury KW - Consumers KW - Marine crustaceans KW - Q5 08504:Effects on organisms KW - Q1 08425:Nutrition and feeding habits KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Korean+Journal+of+Food+Science+and+Technology&rft.atitle=Monitoring+Total+Mercury+and+Methylmercury+in+Mainly+Consumed+Aquatic+Foods&rft.au=Joo%2C+HJ%3BNoh%2C+MJ%3BYoo%2C+J+H%3BJang%2C+Y+M%3BPark%2C+J+S%3BKang%2C+M+H%3BKim%2C+M&rft.aulast=Joo&rft.aufirst=HJ&rft.date=2010-01-01&rft.volume=42&rft.issue=3&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Korean+Journal+of+Food+Science+and+Technology&rft.issn=03676293&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Marine fish; Food consumption; Methyl mercury; Food additives; Body weight; Chromatographic techniques; Mercury; Marine molluscs; Consumers; Kelps; Marine crustaceans; Octopus; Decapoda; Scomber; INW, Japan; INE, USA, Alaska; Freshwater; Brackish; Marine ER - TY - RPRT T1 - Machine Operator Dies when a Molding Press Machine Closes on Him AN - 746164220; 13109897 AB - A 27-year-old male Hispanic machine operator died when he was crushed in a molding press machine that closed on him. The victim was in the process of setting up the machine when a piece of plastic dropped inside. The victim reached inside to retrieve it, and the machine closed and crushed him. It is not known if the victim had received training about how to safely retrieve displaced material. The CA/FACE investigator determined that, in order to prevent future occurrences: Press machine manufacturers should design presses that minimize the chances of material falling into or becoming lodged in the machine. Employers should design and implement machine specific safe work procedures for removal of displaced materials from press machines. Employers should fully train press machine operators in retrieving displaced material and verify their knowledge and skills through testing. JF - Machine Operator Dies when a Molding Press Machine Closes on Him. [np]. Jan 2010. AU - Anonymous Y1 - 2010/01// PY - 2010 DA - Jan 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Training KW - Ethnic groups KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746164220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Machine+Operator+Dies+when+a+Molding+Press+Machine+Closes+on+Him&rft.title=Machine+Operator+Dies+when+a+Molding+Press+Machine+Closes+on+Him&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - RPRT T1 - Roof Man Dies When He Falls From the Roof of a Two-Story House While Applying a Tent for Fumigation AN - 746163850; 13109895 AB - A 33-year-old Hispanic roof man died after he fell approximately 25 feet from the roof of a two-story house to the ground below. The victim was carrying a tarp to cover the roof when the incident occurred. The employer of the victim did not have a fall prevention program for their employees, and the victim was not wearing any personal fall protection device. The CA/FACE investigator determined that: Structural fumigation companies should establish and implement a fall protection program for employees who work on roofs. JF - Roof Man Dies When He Falls From the Roof of a Two-Story House While Applying a Tent for Fumigation. [np]. Jan 2010. AU - Anonymous Y1 - 2010/01// PY - 2010 DA - Jan 2010 PB - National Institute for Occupational Safety and Health, 4676 Columbia Parkway Cincinnati OH 45226-1998 USA, [URL:http://www.cdc.gov/niosh/homepage.html] KW - Health & Safety Science Abstracts KW - Housing KW - Residential areas KW - Fumigation KW - Ethnic groups KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746163850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2010-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Roof+Man+Dies+When+He+Falls+From+the+Roof+of+a+Two-Story+House+While+Applying+a+Tent+for+Fumigation&rft.title=Roof+Man+Dies+When+He+Falls+From+the+Roof+of+a+Two-Story+House+While+Applying+a+Tent+for+Fumigation&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Ability of Healthcare Workers to Recall Previous Receipt of Tetanus- Containing Vaccination AN - 745977288; 12845300 AB - Vaccination of healthcare workers (HCWs) is an important strategy in the control and prevention of hospital outbreaks. The decision to vaccinate is often based on self-report of vaccination status. Self-report of previous receipt of tetanus-diphtheria or tetanus toxin vaccination was validated using an electronic medical record. Results showed that HCWs' self-report is reliable during a vaccination campaign. JF - Infection Control and Hospital Epidemiology AU - Fontanilla, Jose-Mario AU - Kirkland, Kathryn B AU - Cotter, JGavin AU - Talbot, Elizabeth A AD - Dartmouth Hitchcock Medical Center, Lebanon, the Dartmouth Medical School, Hanover, and the New Hampshire Department of Health and Human Services, Concord, New Hampshire., jmfontanilla@yahoo.com Y1 - 2010 PY - 2010 DA - 2010 SP - 647 EP - 649 PB - University of Chicago Press, P.O. Box 37005 Chicago IL 60637 USA, [mailto:help@press.uchicago.edu], [URL:http://www.journals.uchicago.edu/] VL - 31 IS - 6 SN - 0899-823X, 0899-823X KW - Microbiology Abstracts B: Bacteriology KW - tetanus toxin KW - Vaccination KW - Medical personnel KW - electronic medical records KW - Hospitals KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745977288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+Control+and+Hospital+Epidemiology&rft.atitle=Ability+of+Healthcare+Workers+to+Recall+Previous+Receipt+of+Tetanus-+Containing+Vaccination&rft.au=Fontanilla%2C+Jose-Mario%3BKirkland%2C+Kathryn+B%3BCotter%2C+JGavin%3BTalbot%2C+Elizabeth+A&rft.aulast=Fontanilla&rft.aufirst=Jose-Mario&rft.date=2010-01-01&rft.volume=31&rft.issue=6&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Infection+Control+and+Hospital+Epidemiology&rft.issn=0899823X&rft_id=info:doi/10.1086%2F652771 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - tetanus toxin; Vaccination; electronic medical records; Medical personnel; Hospitals DO - http://dx.doi.org/10.1086/652771 ER - TY - JOUR T1 - The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes AN - 745973769; 11838156 AB - Abstract. Shvedova AA, Kagan VE (NIOSH and WVU, Morgantown, WV; University of Pittsburgh, Pittsburgh, PA; USA). The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes (Review). J Intern Med 2010; 267: 106-118Nano-sized materials and nano-scaled processes are widely used in many industries. They are being actively introduced as diagnostic and therapeutic in biomedicine and they are found in numerous consumer products. The small size of nanoparticles, comparable with molecular machinery of cells, may affect normal physiological functions of cells and cause cytotoxicity. Their toxic potential cannot be extrapolated from studies of larger particles due to unique physicochemical properties of nanomaterials. Therefore, the use of nanomaterials may pose unknown risks to human health and the environment. This review discusses several important issues relevant to pulmonary toxicity of nanoparticles, especially single-walled carbon nanotubes (SWCNT), their direct cytotoxic effects, their ability to cause an inflammatory response, and induce oxidative stress upon pharyngeal aspiration or inhalation. Further, recognition and engulfment of nanotubes by macrophages as they relate to phagocytosis and bio-distribution of nanotubes in tissues and circulation are discussed. The immunosuppressive effects of CNT and their significance in increased sensitivity of exposed individuals to microbial infections are summarized. Finally, data on biodegradation of SWCNT by oxidative enzymes of inflammatory cells are presented in lieu of their persistence and distribution in the body. JF - Journal of Internal Medicine AU - Shvedova, A A AU - Kagan, V E AD - From the 1Pathology & Physiology Research Branch-NIOSH-CDC Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 106 EP - 118 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 267 IS - 1 SN - 0954-6820, 0954-6820 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - biodegradation KW - lung KW - oxidative stress KW - single-walled carbon nanotubes KW - Macrophages KW - Inhalation KW - Biodegradation KW - Pharynx KW - Data processing KW - Physicochemical properties KW - Enzymes KW - Toxicity KW - Infection KW - Inflammation KW - Cytotoxicity KW - Carbon KW - Oxidative stress KW - Lung KW - Reviews KW - nanotubes KW - Consumers KW - Phagocytosis KW - nanoparticles KW - nanotechnology KW - Immunosuppression KW - W 30950:Waste Treatment & Pollution Clean-up KW - A 01320:Microbial Degradation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745973769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Internal+Medicine&rft.atitle=The+role+of+nanotoxicology+in+realizing+the+%27helping+without+harm%27+paradigm+of+nanomedicine%3A+lessons+from+studies+of+pulmonary+effects+of+single-walled+carbon+nanotubes&rft.au=Shvedova%2C+A+A%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2010-01-01&rft.volume=267&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+Internal+Medicine&rft.issn=09546820&rft_id=info:doi/10.1111%2Fj.1365-2796.2009.02188.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Inhalation; Macrophages; Data processing; Pharynx; Biodegradation; Physicochemical properties; Enzymes; Toxicity; Infection; Inflammation; Cytotoxicity; Carbon; Lung; Oxidative stress; Reviews; nanotubes; Consumers; Phagocytosis; nanoparticles; Immunosuppression; nanotechnology DO - http://dx.doi.org/10.1111/j.1365-2796.2009.02188.x ER - TY - JOUR T1 - Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic AN - 745712803; 13017172 AB - Acrylamide (CH2 CHCONH2, CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in humans is well known from occupational and accidental exposures. In addition, experimental studies with acrylamide in animals have shown reproductive, genotoxic and carcinogenic properties. Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing. JF - Food and Chemical Toxicology AU - Michael Bolger, P AU - Leblanc, Jean-Charles AU - Woodrow Setzer, R AD - US Food and Drug Administration, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - S25 EP - S33 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK VL - 48 SN - 0278-6915, 0278-6915 KW - Water Resources Abstracts; Toxicology Abstracts; Aqualine Abstracts KW - Acrylamide KW - Margin of Exposure (MoE) KW - Food KW - Drinking Water KW - Exposure KW - Cooking KW - Water Treatment KW - Carbohydrates KW - Occupational exposure KW - Flocculants KW - Temperature effects KW - Genotoxicity KW - Temperature KW - Toxicity KW - Foods KW - Industrial applications KW - Water Pollution Effects KW - Neurotoxicity KW - Proteins KW - SW 3050:Ultimate disposal of wastes KW - AQ 00008:Effects of Pollution KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745712803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Application+of+the+Margin+of+Exposure+%28MoE%29+approach+to+substances+in+food+that+are+genotoxic+and+carcinogenic&rft.au=Michael+Bolger%2C+P%3BLeblanc%2C+Jean-Charles%3BWoodrow+Setzer%2C+R&rft.aulast=Michael+Bolger&rft.aufirst=P&rft.date=2010-01-01&rft.volume=48&rft.issue=&rft.spage=S25&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2009.11.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Temperature effects; Acrylamide; Industrial applications; Food; Cooking; Neurotoxicity; Genotoxicity; Carbohydrates; Flocculants; Occupational exposure; Foods; Drinking Water; Exposure; Water Pollution Effects; Temperature; Water Treatment; Proteins; Toxicity DO - http://dx.doi.org/10.1016/j.fct.2009.11.040 ER - TY - JOUR T1 - Occupational injuries among emergency responders AN - 745631036; 12739876 AB - Background Emergency responders frequently incur injuries while providing medical, fire, and law enforcement services. National surveillance systems provide fragmented perspectives on responder injuries because they omit specific classes of workers (e.g., government or volunteers); they report only selected injuries; and employment information is incomplete. Methods We characterized injuries among emergency medical services (EMS), firefighting, and police occupations by using data from the National Electronic Injury Surveillance System - Occupational Supplement (NEISS-Work) for injuries treated in U.S. hospital emergency departments in 2000-2001. Results Sprains and strains were the leading injury (33-41%) among EMS, firefighter, and police occupations. Police officers and career firefighters had the highest injury rates (8.5 and 7.4 injuries per 100 full-time equivalent workers, respectively). Conclusions The physical demands of emergency response are a leading cause of injuries that may benefit from similar interventions across the occupations. To assess risk, improved exposure data need to be acquired, particularly for volunteers. Am. J. Ind. Med. 53:1-11, 2010. Published 2009 Wiley-Liss, Inc. JF - American Journal of Industrial Medicine AU - Reichard, Audrey A AU - Jackson, Larry L AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, akr5@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1 EP - 11 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 53 IS - 1 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Fires KW - employment KW - firefighter services KW - Injuries KW - Occupational safety KW - careers KW - USA KW - police KW - intervention KW - Emergency preparedness KW - law enforcement KW - emergency medical services KW - Occupational exposure KW - Hospitals KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745631036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Occupational+injuries+among+emergency+responders&rft.au=Reichard%2C+Audrey+A%3BJackson%2C+Larry+L&rft.aulast=Reichard&rft.aufirst=Audrey&rft.date=2010-01-01&rft.volume=53&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.20772 L2 - http://www3.interscience.wiley.com/journal/122677318/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Fires; employment; Injuries; firefighter services; Occupational safety; careers; police; Emergency preparedness; intervention; law enforcement; Occupational exposure; emergency medical services; Hospitals; USA DO - http://dx.doi.org/10.1002/ajim.20772 ER - TY - JOUR T1 - Issues Related to HIV Stigma in Nepal AN - 744713766; 12677823 AB - We conducted a qualitative study to understand and describe experiences of people living with HIV and AIDS with regard to HIV-associated stigma in Nepal. The study has revealed four key themes associated with HIV stigma: a hierarchy of stigma (sexual transmission and women stigmatized more than injecting-drug transmission and men); exclusion and rejection (denial of care services, rejection from family); death as a form of punishment (untimely death is seen as a punishment for something done wrong in the past); and Mumbaiya disease (caught from working in 'other places'). Cultural contexts are the best ways to understand HIV stigma in Nepal along with socially and culturally established gender roles. This study has confirmed that stigma manifests at different levels: individual, social, and structural, with denial and rejection being a key mechanism of stigma. JF - International Journal of Sexual Health AU - Nepal, Vishnu Prasad AU - Ross, Michael W AD - Houston Department of Health and Human Services, Houston, Texas Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 20 EP - 31 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 22 IS - 1 SN - 1931-7611, 1931-7611 KW - Risk Abstracts KW - Mortality KW - Acquired immune deficiency syndrome KW - Nepal KW - Human immunodeficiency virus KW - Gender KW - culture KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744713766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Sexual+Health&rft.atitle=Issues+Related+to+HIV+Stigma+in+Nepal&rft.au=Nepal%2C+Vishnu+Prasad%3BRoss%2C+Michael+W&rft.aulast=Nepal&rft.aufirst=Vishnu&rft.date=2010-01-01&rft.volume=22&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Sexual+Health&rft.issn=19317611&rft_id=info:doi/10.1080%2F19317610903393142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Mortality; Acquired immune deficiency syndrome; Human immunodeficiency virus; Gender; culture; Nepal DO - http://dx.doi.org/10.1080/19317610903393142 ER - TY - JOUR T1 - Tungsten Carbide-Cobalt Particles Activate Nrf2 and Its Downstream Target Genes in JB6 Cells Possibly by ROS Generation AN - 744690601; 13002587 AB - Hard metal consisting of a mixture of tungsten carbide (WC) and metallic cobalt (Co) was evaluated as a possible carcinogen in humans by IARC in 2003. Studies have suggested that nuclear factor erythroid 2-related factor 2 (Nrf2) constitutes one of the chemical-sensing and transcription systems that play an essential role(s) in chemical toxicity, carcinogenesis, and pathological processes. To elucidate the mechanisms of health hazards of WC-Co, effects of nano-WC-Co particles on Nrf2 signaling pathway were investigated in the present study in a JB6 cell line. After a 5 h treatment with nano-WC-Co particles, Nrf2 was released from Keap1 in the cytoplasm and translocated into the nucleus. Enzymatic activities of Nrf2 target genes, including glutathione S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1), increased at 24 and 48 h after the treatment. Studies using reactive oxygen species (ROS) sensitive dyes indicated that ROS were produced in nano-WC-Co particle-treated cells. Pretreatment of the cells with catalase, but not sodium formate, resulted in a significant inhibitory effect on nano-WC-Co particle-induced Nrf2 target gene activation. These findings suggest that activation of Nrf2 and its downstream genes may be initiated by ROS generation, and ROS may act as a major contributor in nano-WC-Co particle-induced adverse health effects. JF - Journal of Environmental Pathology, Toxicology and Oncology AU - Zhang, Xing-Dong AU - Zhao, Jinshun AU - Bowman, Linda AU - Shi, Xianglin AU - Castranova, Vincent AU - Ding, Min AD - Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40515; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 Y1 - 2010 PY - 2010 DA - 2010 SP - 31 EP - 40 PB - Begell House Inc., 79 Madison Avenue, Suite 1201 New York NY 10016-7892 USA VL - 29 IS - 1 SN - 0731-8898, 0731-8898 KW - Toxicology Abstracts; Pollution Abstracts KW - Pathology KW - Heavy metals KW - tungsten carbide KW - Particulates KW - Carcinogens KW - Glutathione transferase KW - Tungsten KW - Reactive oxygen species KW - Cytoplasm KW - Cobalt KW - sodium formate KW - Enzymatic activity KW - Nuclei KW - Metals KW - NAD(P)H:quinone oxidoreductase KW - NRF2 protein KW - Transcription KW - Toxicity KW - Catalase KW - Sodium KW - Dyes KW - Carcinogenesis KW - downstream KW - NAD(P)H dehydrogenase (quinone) KW - Transcription activation KW - Signal transduction KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744690601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.atitle=Tungsten+Carbide-Cobalt+Particles+Activate+Nrf2+and+Its+Downstream+Target+Genes+in+JB6+Cells+Possibly+by+ROS+Generation&rft.au=Zhang%2C+Xing-Dong%3BZhao%2C+Jinshun%3BBowman%2C+Linda%3BShi%2C+Xianglin%3BCastranova%2C+Vincent%3BDing%2C+Min&rft.aulast=Zhang&rft.aufirst=Xing-Dong&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Pathology%2C+Toxicology+and+Oncology&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heavy metals; Transcription; NRF2 protein; NAD(P)H:quinone oxidoreductase; tungsten carbide; Toxicity; Carcinogens; Glutathione transferase; Catalase; Tungsten; Dyes; Reactive oxygen species; Cobalt; Cytoplasm; Carcinogenesis; sodium formate; NAD(P)H dehydrogenase (quinone); Enzymatic activity; Nuclei; Transcription activation; Signal transduction; Sodium; Metals; Pathology; downstream; Particulates ER - TY - JOUR T1 - Introduction and the development direction on the detection technique of harmful micro-organisms in dairy products AN - 744670482; 12678520 AB - This paper, in terms of food safety, systematically reviews disadvantage of main high-hazard pathogens in dairy products and the historical process of the detection method, the detection technique of harmful micro-organisms in milk on current domestic and international, the direction of development of microbial detection techniques in milk. JF - China Dairy Industry AU - Zhang, S-W AU - Yin, L AU - Zhou, Y-L AD - Heilongjiang Food and Drug Administration, Harbin 150020, China Y1 - 2010 PY - 2010 DA - 2010 SP - 35 EP - 38 VL - 38 IS - 1 SN - 1001-2230, 1001-2230 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Milk KW - Food KW - Dairy industry KW - Dairy products KW - Pathogens KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=China+Dairy+Industry&rft.atitle=Introduction+and+the+development+direction+on+the+detection+technique+of+harmful+micro-organisms+in+dairy+products&rft.au=Zhang%2C+S-W%3BYin%2C+L%3BZhou%2C+Y-L&rft.aulast=Zhang&rft.aufirst=S-W&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=China+Dairy+Industry&rft.issn=10012230&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Milk; Dairy industry; Food; Dairy products; Pathogens ER - TY - JOUR T1 - ROPS Performance during Field Upset and Static Testing AN - 744618389; 12912712 AB - Agriculture remains one of the most hazardous occupations in the U.S. By conservative estimates, tractor overturns alone claim 120 lives annually. A rollover protective structure (ROPS) and a seatbelt are a highly effective engineering safety control that can prevent many of these fatalities and reduce the severity of injuries associated with tractor overturn. SAE J2194 is a consensus performance standard established for agricultural ROPS. According to this standard, satisfactory ROPS performance can be demonstrated through static testing, field upset testing, or impact testing. A previous modeling study suggested that static testing may underpredict the strain induced in a ROPS during a field upset. In the current study, field upset testing and laboratory static testing results were compared. Field upset testing included six rear and six side upset tests performed according to SAE J2194 guidelines. Additionally, static testing was performed on a ROPS of the same model. The results support findings from the modeling study. Near the lowest sections of the ROPS, the plastic strain resulting from rear upset testing exceeded the plastic strain from static testing for 18 of 24 data points. Conversely, the ROPS plastic strain from side upset testing was typically less than plastic strain from laboratory static testing. However, data indicate that the side upset test may not be very repeatable. This study suggests that the longitudinal loading energy criterion for static testing might not be a conservative predictor of rear upset ROPS response. JF - Journal of Agricultural Safety and Health AU - Harris, J R AU - McKenzie, EA Jr AU - Etherton, J R AU - Cantis, D M AU - Ronaghi, M AD - NIOSH Division of Safety Research, MS G800, 1095 Willowdale Rd., Morgantown, West Virginia, USA, jharris@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 5 EP - 18 VL - 16 IS - 1 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - Mortality KW - USA KW - safety engineering KW - Injuries KW - guidelines KW - agriculture KW - rollover KW - Agricultural equipment KW - seat belts KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744618389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=ROPS+Performance+during+Field+Upset+and+Static+Testing&rft.au=Harris%2C+J+R%3BMcKenzie%2C+EA+Jr%3BEtherton%2C+J+R%3BCantis%2C+D+M%3BRonaghi%2C+M&rft.aulast=Harris&rft.aufirst=J&rft.date=2010-01-01&rft.volume=16&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Mortality; safety engineering; Injuries; guidelines; agriculture; rollover; seat belts; Agricultural equipment; USA ER - TY - JOUR T1 - Work-Related Non-Fatal Injuries to Adults on Farms in the U.S., 2001 and 2004 AN - 744617739; 12912715 AB - The National Institute for Occupational Safety and Health (NIOSH), in an ongoing effort to address the issue of injuries on farms in the U.S., collaborated with the USDA to complete the 2001 and 2004 Occupational Injury Surveillance of Production Agriculture Surveys (OISPAS). The OISPAS data indicated that the estimated adult working population (household and hired) on U.S. farms decreased from 6,170,940 in 2001 to 5,294,912 in 2004. The estimated number of work-related injuries decreased from 75,756 to 71,081. The rate of injury increased over this same time period (12.3 injuries per 1,000 working adults to 13.4 injuries per 1,000 working adults). The majority of these injuries occurred to adults in the age range of 45 to 54 years. The vast majority of injuries occurred to males, over 75% in both years. Animals (17%) and the ground (17%) were the source of injury in approximately 35% of injuries reported in each year. The most common injury events were "struck by objects" and falls. These two events combined accounted for over half of all work-related injuries in both 2001 and 2004. The OISPAS data indicated that although injuries are decreasing as the size of the at-risk population decreases, the rate of injury is increasing. The results of this research may be used to direct current injury prevention efforts and to plan for future injury surveillance. JF - Journal of Agricultural Safety and Health AU - Goldcamp, E M AD - NIOSH, Division of Safety Research, 1095 Willowdale Rd., Morgantown, West Virginia 26505, USA, mgoldcamp@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 41 EP - 51 VL - 16 IS - 1 SN - 1074-7583, 1074-7583 KW - Health & Safety Science Abstracts KW - USA KW - households KW - Age KW - Injuries KW - farms KW - Occupational safety KW - prevention KW - agriculture KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744617739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agricultural+Safety+and+Health&rft.atitle=Work-Related+Non-Fatal+Injuries+to+Adults+on+Farms+in+the+U.S.%2C+2001+and+2004&rft.au=Goldcamp%2C+E+M&rft.aulast=Goldcamp&rft.aufirst=E&rft.date=2010-01-01&rft.volume=16&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agricultural+Safety+and+Health&rft.issn=10747583&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Age; households; Injuries; farms; Occupational safety; agriculture; prevention; USA ER - TY - JOUR T1 - Reducing sex under the influence of drugs or alcohol for patients in substance abuse treatment AN - 743790937; 3957439 AB - Aims In a previous report, the effectiveness of the Real Men Are Safe (REMAS) intervention in reducing the number of unprotected sexual occassions among male drug abuse treatment patients was demonstrated. A secondary aim of REMAS was to reduce the frequency with which men engage in sex under the influence (SUI) of drugs or alcohol. Design Men in methadone maintenance (n = 173) or out-patient pscychosocial treatment (n = 104) completed assessments at baseline, 3 and 6 months post-intervention. Participants The participants were assigned randomly to attend either REMAS (five sessions containing information, motivational exercises and skills training, including one session specifically targeting reducing SUI) or human immunodeficiency virus (HIV) education (HIV-Ed; one session containing HIV prevention information). SUI during the most recent sexual event served as the primary outcome in a repeated measures logistic regression model. Findings Men assigned to the REMAS condition reporting SUI at the most recent sexual event decreased from 36.8% at baseline to 25.7% at 3 months compared to a increase from 36.9% to 38.3% in the HIV-Ed condition (tintervention = -2.16, P = 0.032). No difference between the treatment groups was evident at 6-month follow-up. At each assessment time-point, sex with a casual partner versus a regular partner, and being in methadone maintenance versus psychosocial out-patient treatment, were associated with engaging in SUI. Conclusions Overall, a motivational and skills training HIV prevention intervention designed for men was associated with greater reduction in SUI than standard HIV education at the 3-month follow-up. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Calsyn, Donald A AU - Crits-Christoph, Paul AU - Hatch-Maillette, Mary A AU - Doyle, Suzanne R AU - Song, Yong S AU - Coyer, Susan AU - Pelta, Sara AD - University of Washington ; University of Pennsylvania ; University of California, San Francisco ; Prestera Center for Mental Health Services Inc Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 100 EP - 108 VL - 105 IS - 1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Prevention KW - Medical treatment KW - Addiction KW - Drug abuse KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/743790937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Reducing+sex+under+the+influence+of+drugs+or+alcohol+for+patients+in+substance+abuse+treatment&rft.au=Calsyn%2C+Donald+A%3BCrits-Christoph%2C+Paul%3BHatch-Maillette%2C+Mary+A%3BDoyle%2C+Suzanne+R%3BSong%2C+Yong+S%3BCoyer%2C+Susan%3BPelta%2C+Sara&rft.aulast=Calsyn&rft.aufirst=Donald&rft.date=2010-01-01&rft.volume=105&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2009.02812.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 10072; 3742 1121 11776 3753 3755; 7890 5792 10484; 561 6220 DO - http://dx.doi.org/10.1111/j.1360-0443.2009.02812.x ER - TY - JOUR T1 - Overview of TCE-HIV Grant Programs AN - 741611019; 201006258 AB - Abstract not available. JF - Journal of Evidence-Based Social Work AU - Thompson, David C AD - Team Leader-HIV/AIDS Programs, Systems Improvement Branch/Division of Services Improvement, Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, Maryland, USA Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 3 EP - 4 PB - Haworth Press/Taylor & Francis, Philadelphia PA VL - 7 IS - 1-2 SN - 1543-3714, 1543-3714 KW - Finance KW - Acquired Immune Deficiency Syndrome KW - Social Services KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/741611019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Evidence-Based+Social+Work&rft.atitle=Overview+of+TCE-HIV+Grant+Programs&rft.au=Thompson%2C+David+C&rft.aulast=Thompson&rft.aufirst=David&rft.date=2010-01-01&rft.volume=7&rft.issue=1-2&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Evidence-Based+Social+Work&rft.issn=15433714&rft_id=info:doi/10.1080%2F15433710903175825 LA - English DB - Social Services Abstracts N1 - Date revised - 2010-05-10 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Social Services; Finance DO - http://dx.doi.org/10.1080/15433710903175825 ER - TY - JOUR T1 - The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes. AN - 734231327; 20059647 AB - Nano-sized materials and nano-scaled processes are widely used in many industries. They are being actively introduced as diagnostic and therapeutic in biomedicine and they are found in numerous consumer products. The small size of nanoparticles, comparable with molecular machinery of cells, may affect normal physiological functions of cells and cause cytotoxicity. Their toxic potential cannot be extrapolated from studies of larger particles due to unique physicochemical properties of nanomaterials. Therefore, the use of nanomaterials may pose unknown risks to human health and the environment. This review discusses several important issues relevant to pulmonary toxicity of nanoparticles, especially single-walled carbon nanotubes (SWCNT), their direct cytotoxic effects, their ability to cause an inflammatory response, and induce oxidative stress upon pharyngeal aspiration or inhalation. Further, recognition and engulfment of nanotubes by macrophages as they relate to phagocytosis and bio-distribution of nanotubes in tissues and circulation are discussed. The immunosuppressive effects of CNT and their significance in increased sensitivity of exposed individuals to microbial infections are summarized. Finally, data on biodegradation of SWCNT by oxidative enzymes of inflammatory cells are presented in lieu of their persistence and distribution in the body. JF - Journal of internal medicine AU - Shvedova, A A AU - Kagan, V E AD - Pathology & Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health/CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA. ats1@cdc.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 106 EP - 118 VL - 267 IS - 1 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Inhalation KW - Animals KW - Humans KW - Oxidative Stress -- immunology KW - Lung -- immunology KW - Pulmonary Fibrosis -- immunology KW - Nanomedicine -- ethics KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- etiology KW - Nanoparticles -- adverse effects KW - Lung -- pathology KW - Nanotubes, Carbon -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734231327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+internal+medicine&rft.atitle=The+role+of+nanotoxicology+in+realizing+the+%27helping+without+harm%27+paradigm+of+nanomedicine%3A+lessons+from+studies+of+pulmonary+effects+of+single-walled+carbon+nanotubes.&rft.au=Shvedova%2C+A+A%3BKagan%2C+V+E&rft.aulast=Shvedova&rft.aufirst=A&rft.date=2010-01-01&rft.volume=267&rft.issue=1&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Journal+of+internal+medicine&rft.issn=1365-2796&rft_id=info:doi/10.1111%2Fj.1365-2796.2009.02188.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-18 N1 - Date created - 2010-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1365-2796.2009.02188.x ER - TY - JOUR T1 - Application of microarray-based analysis of gene expression in the field of toxicogenomics. AN - 734193756; 20013237 AB - The field of toxicogenomics, which is becoming an important sub-discipline of toxicology, resulted from the natural convergence of the field of conventional toxicological research and the emergent field of functional genomics. One technology that has played a significant role in the field of toxicogenomics (in addition to many others) is the gene expression microarray. In this chapter, the authors provide an example of the application of gene expression microarrays to the field of toxicogenomics by detailing the strategy that was used for obtaining, analyzing, and interpreting gene expression data generated from RNA isolated from the liver of toxicant-exposed rats. JF - Methods in molecular biology (Clifton, N.J.) AU - Mei, Nan AU - Fuscoe, James C AU - Lobenhofer, Edward K AU - Guo, Lei AD - Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2010 PY - 2010 DA - 2010 SP - 227 EP - 241 VL - 597 KW - Mutagens KW - 0 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Liver -- drug effects KW - RNA -- isolation & purification KW - Liver -- metabolism KW - Mutagens -- pharmacology KW - Microarray Analysis -- methods KW - Toxicogenetics -- methods KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734193756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=Application+of+microarray-based+analysis+of+gene+expression+in+the+field+of+toxicogenomics.&rft.au=Mei%2C+Nan%3BFuscoe%2C+James+C%3BLobenhofer%2C+Edward+K%3BGuo%2C+Lei&rft.aulast=Mei&rft.aufirst=Nan&rft.date=2010-01-01&rft.volume=597&rft.issue=&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=1940-6029&rft_id=info:doi/10.1007%2F978-1-60327-389-3_16 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/978-1-60327-389-3_16 ER - TY - JOUR T1 - Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin. AN - 734167324; 19956833 AB - Quercitrin, glycosylated form of flavonoid compounds, is widely distributed in nature. Extensive studies have demonstrated that quercitrin exhibits strong antioxidant and anti-carcinogenic activities. However, the molecular mechanism is poorly understood. The present study examines the effects of quercitrin on tumor promotion in mouse JB6 cells, a validated model for screening cancer chemopreventive agents and elucidating the molecular mechanisms. Quercitrin blocked TPA-induced neoplastic transformation in JB6 P+ cells. Pretreatment of JB6 cells with quercitrin down-regulated transactivation of AP-1 and NF-kappaB induced by UVB or TPA. In the skin of AP-1-luciferase transgenic mice, topical treatment of the mouse with quercitrin markedly blocked the TPA-induced AP-1 transactivation. Further studies indicated that these inhibitory actions appear to be mediated through the inhibition of MAPKs phosphorylation, including ERKs, p38 kinase, and JNKs. In addition, quercitrin stimulated the activation of NF-E2-related factor (Nrf2) and GST ARE-luciferase activity. Comet assays showed that quercitrin could block DNA damage induced by UVB. To our knowledge, these results provide the first evidence that quercitrin contributes to the inhibition of neoplastic transformation by blocking activation of the MAPK pathway and stimulation of cellular protection signaling. Moreover, to our knowledge, these findings provide the first molecular basis for the anti-carcinogenic action of quercitrin. JF - International journal of oncology AU - Ding, Min AU - Zhao, Jinshun AU - Bowman, Linda AU - Lu, Yongju AU - Shi, Xianglin AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. mid5@cdc.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 59 EP - 67 VL - 36 IS - 1 KW - Antioxidants KW - 0 KW - Carcinogens KW - Enzyme Inhibitors KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Transcription Factor AP-1 KW - quercitrin KW - 2Y8906LC5P KW - Quercetin KW - 9IKM0I5T1E KW - Index Medicus KW - Comet Assay KW - Animals KW - Enzyme Activation KW - Mice KW - Mice, Transgenic KW - Transcriptional Activation KW - Male KW - Female KW - Gene Expression Regulation, Neoplastic KW - MAP Kinase Signaling System KW - Antioxidants -- metabolism KW - Transcription Factor AP-1 -- antagonists & inhibitors KW - Quercetin -- analogs & derivatives KW - NF-E2-Related Factor 2 -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Response Elements KW - Quercetin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734167324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Inhibition+of+AP-1+and+MAPK+signaling+and+activation+of+Nrf2%2FARE+pathway+by+quercitrin.&rft.au=Ding%2C+Min%3BZhao%2C+Jinshun%3BBowman%2C+Linda%3BLu%2C+Yongju%3BShi%2C+Xianglin&rft.aulast=Ding&rft.aufirst=Min&rft.date=2010-01-01&rft.volume=36&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=1791-2423&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-02-22 N1 - Date created - 2009-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicogenomics and studies of genomic effects of dietary components. AN - 733940037; 20436258 JF - World review of nutrition and dietetics AU - Thompson, Karol AD - Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Md., USA. karol.thompson@fda.hhs.gov Y1 - 2010 PY - 2010 DA - 2010 SP - 115 EP - 122 VL - 101 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Gene Expression Profiling KW - Toxicogenetics KW - Transcription, Genetic KW - Nutrigenomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733940037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+review+of+nutrition+and+dietetics&rft.atitle=Toxicogenomics+and+studies+of+genomic+effects+of+dietary+components.&rft.au=Thompson%2C+Karol&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2010-01-01&rft.volume=101&rft.issue=&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=World+review+of+nutrition+and+dietetics&rft.issn=1662-3975&rft_id=info:doi/10.1159%2F000314516 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-31 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000314516 ER - TY - JOUR T1 - Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. AN - 733939948; 20436259 JF - World review of nutrition and dietetics AU - Starlard-Davenport, Athena AU - Tryndyak, Volodymyr AU - Kosyk, Oksana AU - Ross, Sharon R AU - Rusyn, Ivan AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Ariz. 72079, USA. Y1 - 2010 PY - 2010 DA - 2010 SP - 123 EP - 130 VL - 101 KW - DNA, Neoplasm KW - 0 KW - MicroRNAs KW - Methionine KW - AE28F7PNPL KW - Index Medicus KW - Animals KW - Folic Acid Deficiency -- metabolism KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Mice, Inbred DBA KW - Choline Deficiency -- metabolism KW - Liver Neoplasms, Experimental -- etiology KW - DNA Methylation KW - Methionine -- metabolism KW - Methionine -- deficiency KW - DNA, Neoplasm -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733939948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+review+of+nutrition+and+dietetics&rft.atitle=Dietary+methyl+deficiency%2C+microRNA+expression+and+susceptibility+to+liver+carcinogenesis.&rft.au=Starlard-Davenport%2C+Athena%3BTryndyak%2C+Volodymyr%3BKosyk%2C+Oksana%3BRoss%2C+Sharon+R%3BRusyn%2C+Ivan%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Starlard-Davenport&rft.aufirst=Athena&rft.date=2010-01-01&rft.volume=101&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=World+review+of+nutrition+and+dietetics&rft.issn=1662-3975&rft_id=info:doi/10.1159%2F000314517 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-08-31 N1 - Date created - 2010-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1159/000314517 ER - TY - JOUR T1 - Genome-wide association studies in cancer--current and future directions. AN - 733935126; 19906782 AB - Genome-wide association studies (GWAS) have emerged as an important tool for discovering regions of the genome that harbor genetic variants that confer risk for different types of cancers. The success of GWAS in the last 3 years is due to the convergence of new technologies that can genotype hundreds of thousands of single-nucleotide polymorphism markers together with comprehensive annotation of genetic variation. This approach has provided the opportunity to scan across the genome in a sufficiently large set of cases and controls without a set of prior hypotheses in search of susceptibility alleles with low effect sizes. Generally, the susceptibility alleles discovered thus far are common, namely, with a frequency in one or more population of >10% and each allele confers a small contribution to the overall risk for the disease. For nearly all regions conclusively identified by GWAS, the per allele effect sizes estimated are 30 distinct regions harboring common susceptibility alleles identified by GWAS, whereas in lung cancer, a disease strongly driven by exposure to tobacco products, so far, only three regions have been conclusively established. To date, >85 regions have been conclusively associated in over a dozen different cancers, yet no more than five regions have been associated with more than one distinct cancer type. GWAS are an important discovery tool that require extensive follow-up to map each region, investigate the biological mechanism underpinning the association and eventually test the optimal markers for assessing risk for a disease or its outcome, such as in pharmacogenomics, the study of the effect of genetic variation on pharmacological interventions. The success of GWAS has opened new horizons for exploration and highlighted the complex genomic architecture of disease susceptibility. JF - Carcinogenesis AU - Chung, Charles C AU - Magalhaes, Wagner C S AU - Gonzalez-Bosquet, Jesus AU - Chanock, Stephen J AD - Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-4608, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 111 EP - 120 VL - 31 IS - 1 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Neoplasms -- genetics KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733935126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genome-wide+association+studies+in+cancer--current+and+future+directions.&rft.au=Chung%2C+Charles+C%3BMagalhaes%2C+Wagner+C+S%3BGonzalez-Bosquet%2C+Jesus%3BChanock%2C+Stephen+J&rft.aulast=Chung&rft.aufirst=Charles&rft.date=2010-01-01&rft.volume=31&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgp273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 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28;447(7148):1087-93 [17529967] Nat Genet. 2007 Aug;39(8):989-94 [17618283] Nat Genet. 2007 Aug;39(8):984-8 [17618284] PLoS Genet. 2006 Dec;2(12):e190 [17194218] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1093/carcin/bgp273 ER - TY - JOUR T1 - Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems. AN - 733714751; 20055698 AB - Engineered nanomaterials have unique physico-chemical properties that make them promising for many technological and biomedical applications, including tissue regeneration, drug and gene delivery, and in vivo monitoring of disease processes. However, with the burgeoning capabilities to manipulate structures at the nano-scale, intentional as well as unintentional human exposures to engineered nanomaterials are set to increase. Nanotoxicology is an emerging discipline focused on understanding the properties of engineered nanomaterials and their interactions with biological systems, and may be viewed as the study of the undesirable interference between man-made nanomaterials and cellular nanostructures or nanomachines. In this review, we discuss recognition of engineered nanomaterials by the immune system, our primary defense system against foreign invasion. Moreover, as oxidative stress is believed to be one of the major deleterious consequences of exposure to nanomaterials, we explore triggering of pro- and antioxidant pathways as well as biomarkers of oxidative stress. Finally, we highlight in vivo studies of the toxicological outcomes of engineered nanomaterials, including carbon nanotubes, with an emphasis on inflammation and genotoxic responses. JF - Annual review of pharmacology and toxicology AU - Shvedova, Anna A AU - Kagan, Valerian E AU - Fadeel, Bengt AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA. ATS1@CDC.GOV Y1 - 2010 PY - 2010 DA - 2010 SP - 63 EP - 88 VL - 50 KW - Nanotubes, Carbon KW - 0 KW - Index Medicus KW - Animals KW - Particle Size KW - Humans KW - Oxidative Stress KW - Cell Physiological Phenomena -- drug effects KW - Nanotubes, Carbon -- adverse effects KW - Nanotechnology KW - Nanostructures -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733714751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+pharmacology+and+toxicology&rft.atitle=Close+encounters+of+the+small+kind%3A+adverse+effects+of+man-made+materials+interfacing+with+the+nano-cosmos+of+biological+systems.&rft.au=Shvedova%2C+Anna+A%3BKagan%2C+Valerian+E%3BFadeel%2C+Bengt&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2010-01-01&rft.volume=50&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+pharmacology+and+toxicology&rft.issn=1545-4304&rft_id=info:doi/10.1146%2Fannurev.pharmtox.010909.105819 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-03-17 N1 - Date created - 2010-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1146/annurev.pharmtox.010909.105819 ER - TY - JOUR T1 - FDA drug approval summary: bevacizumab plus interferon for advanced renal cell carcinoma. AN - 733617422; 20061402 AB - On July 31, 2009, the U.S. Food and Drug Administration granted approval for the use of bevacizumab (Avastin(R); Genentech, Inc., South San Francisco, CA) in combination with interferon (IFN)-alpha2a for the treatment of patients with metastatic renal cell carcinoma. The approval was primarily based on results from a randomized, double-blind, placebo-controlled clinical trial. The primary efficacy endpoint, progression-free survival (PFS), was assessed by investigators and by an independent review committee (IRC) blinded to treatment assignment. In total, 649 patients (bevacizumab plus IFN, 327; placebo plus IFN, 322) were enrolled. The median PFS times, by investigator determination, were 10.2 months for the bevacizumab plus IFN arm and 5.4 months for the placebo plus IFN arm (hazard ratio [HR], 0.60; 95% confidence interval [CI], 0.49-0.72; p /=3 adverse events were reported more frequently in bevacizumab-treated patients (31% versus 19% and 63% versus 47%, respectively). The most common bevacizumab-related toxicities were bleeding/hemorrhage, hypertension, proteinuria, and venous or arterial thromboembolic events. JF - The oncologist AU - Summers, Jeff AU - Cohen, Martin H AU - Keegan, Patricia AU - Pazdur, Richard AD - U.S. Food and Drug Administration, White Oak Campus, 10903 New Hampshire Avenue, Building 22, Room 2113, Silver Spring, Maryland 20993-0002, USA. Y1 - 2010 PY - 2010 DA - 2010 SP - 104 EP - 111 VL - 15 IS - 1 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Interferon-alpha KW - Protein Kinase Inhibitors KW - Quinazolines KW - Recombinant Proteins KW - Vascular Endothelial Growth Factor A KW - Bevacizumab KW - 2S9ZZM9Q9V KW - interferon alfa-2a KW - 47RRR83SK7 KW - Erlotinib Hydrochloride KW - DA87705X9K KW - Index Medicus KW - United States KW - Randomized Controlled Trials as Topic KW - Clinical Trials, Phase II as Topic KW - Endpoint Determination KW - Clinical Trials, Phase III as Topic KW - Humans KW - Protein Kinase Inhibitors -- administration & dosage KW - Vascular Endothelial Growth Factor A -- antagonists & inhibitors KW - Quinazolines -- administration & dosage KW - United States Food and Drug Administration KW - Adult KW - Middle Aged KW - Female KW - Male KW - Kidney Neoplasms -- mortality KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Kidney Neoplasms -- drug therapy KW - Interferon-alpha -- administration & dosage KW - Carcinoma, Renal Cell -- mortality KW - Carcinoma, Renal Cell -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733617422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+drug+approval+summary%3A+bevacizumab+plus+interferon+for+advanced+renal+cell+carcinoma.&rft.au=Summers%2C+Jeff%3BCohen%2C+Martin+H%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Summers&rft.aufirst=Jeff&rft.date=2010-01-01&rft.volume=15&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2009-0250 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-04 N1 - Date created - 2010-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Urol Oncol. 2008 Sep-Oct;26(5):543-9 [18774471] Clin Genitourin Cancer. 2008 Dec;6 Suppl 1:S14-21 [19891125] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cancer J Sci Am. 2000 Feb;6 Suppl 1:S55-7 [10685660] J Clin Oncol. 2002 Jan 1;20(1):289-96 [11773181] J Clin Oncol. 2005 Jan 1;23(1):133-41 [15625368] Cochrane Database Syst Rev. 2005;(1):CD001425 [15674877] J Clin Oncol. 2005 Feb 1;23(4):832-41 [15681528] J Clin Oncol. 2007 Oct 10;25(29):4536-41 [17876014] Cancer. 2007 Dec 1;110(11):2468-77 [17932908] Lancet. 2007 Dec 22;370(9605):2103-11 [18156031] Oncologist. 2007 Dec;12(12):1404-15 [18165617] J Urol. 2008 Sep;180(3):860-5; discussion 865-6 [18635227] Eur J Cancer. 2008 Oct;44(15):2152-61 [18829302] J Clin Oncol. 2008 Nov 20;26(33):5422-8 [18936475] Eur J Cancer. 2009 Jan;45(2):268-74 [19101138] Curr Oncol Rep. 2009 May;11(3):218-26 [19336014] Cancer Treat Rev. 2009 May;35(3):289-96 [19232474] Nat Rev Clin Oncol. 2009 May;6(5):253-4 [19390549] Cancer Chemother Pharmacol. 2009 Jun;64(1):11-25 [19343348] Cancer. 2009 May 15;115(10 Suppl):2368-75 [19402058] Cancer. 2009 May 15;115(10 Suppl):2298-305 [19402060] Cancer. 2009 May 15;115(10 Suppl):2306-12 [19402073] BJU Int. 2009 May;103(10):1334-42 [19338565] Clin Genitourin Cancer. 2008 Dec;6 Suppl 1:S7-13 [19891124] Eur J Cancer. 2008 Nov;44(16):2350-6 [18789679] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1634/theoncologist.2009-0250 ER - TY - JOUR T1 - Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphoma. AN - 733514755; 19809881 AB - Cigarette smoke contains many carcinogens that are metabolically activated through xenobiotic metabolism by phase I and II enzymes, including N-acetyltransferases 1 and 2 (NAT1 and NAT2). We investigated non-Hodgkin lymphoma risk in general and by subtype in relation to NAT1 and NAT2 genotypes and cigarette smoking in a population-based case-control study in Connecticut. Of the 535 controls, 53.1% reported ever smoking, and of the 461 cases, 55.7% reported ever smoking. We found a two-fold increased risk of T-cell lymphoma among those possessing the NAT1*10 genotype compared to those with other NAT1 genotypes; including an OR of 2.0 (95% CI: 1.0-2.4) for those heterozygous or homozygous for NAT1*10 genotypes. Rapid acetylator NAT2 phenotype increased the risk of both T-cell lymphoma (OR = 3.2; 95% CI: 1.1-9.5) and marginal zone lymphoma (OR = 3.0; 95% CI: 1.0-8.7), though these results were based on a small number of cases. When smoking status and risk of NHL was stratified by NAT1 and NAT2 genotypes, an increased risk of NHL overall was observed in current (OR = 1.7; 95% CI: 1.2-2.4) smokers without the NAT1*10 genotype but not among smokers with the NAT1*10 genotype (p-interaction < 0.01). No association between history of cigarette smoking and risk of NHL overall was observed with any NAT2 genotype. Our results present modest evidence that acetylation rate is associated with risk of NHL for specific subtypes and that the NAT1*10 genotype is an "at-risk" allele. Additionally, our results suggest that the relationship between NHL and smoking status may be modified by common genetic variation in NAT1 but not NAT2. We conclude that these findings require replication in larger studies and ultimately in pooled analyses. JF - Cancer causes & control : CCC AU - Kilfoy, Briseis A AU - Zheng, Tongzhang AU - Lan, Qing AU - Han, Xuesong AU - Holford, Theodore AU - Hein, David W AU - Qin, Qin AU - Leaderer, Brian AU - Morton, Lindsay M AU - Yeager, Meredith AU - Boyle, Peter AU - Zhao, Ping AU - Chanock, Stephen AU - Rothman, Nathaniel AU - Zhang, Yawei AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. kilfoyb@mail.nih.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 127 EP - 133 VL - 21 IS - 1 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Lymphoma, Non-Hodgkin -- genetics KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Genetic Variation KW - Smoking -- adverse effects KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- metabolism KW - Isoenzymes -- metabolism KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733514755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Genetic+variation+in+N-acetyltransferases+1+and+2%2C+cigarette+smoking%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Kilfoy%2C+Briseis+A%3BZheng%2C+Tongzhang%3BLan%2C+Qing%3BHan%2C+Xuesong%3BHolford%2C+Theodore%3BHein%2C+David+W%3BQin%2C+Qin%3BLeaderer%2C+Brian%3BMorton%2C+Lindsay+M%3BYeager%2C+Meredith%3BBoyle%2C+Peter%3BZhao%2C+Ping%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel%3BZhang%2C+Yawei&rft.aulast=Kilfoy&rft.aufirst=Briseis&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-009-9442-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-13 N1 - Date created - 2010-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Tumori. 1990 Oct 31;76(5):413-9 [2256184] Leuk Res. 1989;13(6):465-72 [2770331] Leuk Res. 1992 Jun-Jul;16(6-7):621-4 [1635380] Cancer. 1992 Aug 15;70(4):840-9 [1643616] Cancer Res. 1992 Oct 1;52(19 Suppl):5443s-5446s [1394151] Hum Mol Genet. 1995 Feb;4(2):231-6 [7757072] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Cancer Causes Control. 1997 Mar;8(2):159-66 [9134239] Br J Cancer. 1997;76(11):1532-7 [9400954] Cancer Causes Control. 1998 May;9(3):321-9 [9684712] Am J Epidemiol. 1998 Nov 1;148(9):833-41 [9801013] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Ann Hematol. 2005 Jan;84(1):1-12 [15480663] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] N Engl J Med. 2005 Feb 24;352(8):804-15 [15728813] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33 [15824165] Cancer Causes Control. 2005 May;16(4):333-46 [15953976] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Blood. 2006 Jan 1;107(1):265-76 [16150940] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Pharmacogenet Genomics. 2006 Aug;16(8):537-45 [16847422] Hum Genet. 2007 Apr;121(2):161-8 [17149600] Int J Cancer. 2007;120 Suppl 12:1-39 [17405121] Leuk Lymphoma. 2000 Apr;37(3-4):341-9 [10752985] Pharmacogenetics. 2000 Jul;10(5):461-9 [10898115] J Natl Cancer Inst. 2000 Aug 2;92(15):1240-51 [10922409] Cancer Causes Control. 2001 Apr;12(3):201-12 [11405325] Cancer Causes Control. 2001 May;12(4):325-34 [11456228] Cancer. 2002 Apr 1;94(7):2015-23 [11932904] Cancer Causes Control. 2002 Mar;13(2):159-68 [11936822] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] J Natl Cancer Inst. 2002 Aug 21;94(16):1204-10 [12189223] Oncogene. 2002 Oct 21;21(48):7435-51 [12379884] Cancer Causes Control. 2003 Feb;14(1):43-51 [12708724] Pharmacogenetics. 2003 Jul;13(7):399-407 [12835615] Cancer Causes Control. 2003 May;14(4):381-9 [12846371] Br J Cancer. 2003 Dec 1;89(11):2087-92 [14647142] Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):431-7 [15006920] Cancer Causes Control. 2004 May;15(4):419-28 [15141141] Oncogene. 2004 Aug 23;23(38):6524-34 [15322522] Cancer Causes Control. 2004 Oct;15(8):771-80 [15456990] Cancer Causes Control. 1992 Jan;3(1):49-55 [1536913] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9442-8 ER - TY - JOUR T1 - Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study. AN - 733512416; 19784860 AB - Telomeres are structures at chromosome ends that contribute to maintaining genomic integrity. Telomere shortening with repeated cell divisions may lead to genomic instability and carcinogenesis. Studies suggest that shorter telomeres in constitutional DNA are associated with bladder, breast, lung, and renal cancer. Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer. We investigated leukocyte telomere length in 99 women with serous ovarian adenocarcinoma and 100 age-matched cancer-free controls enrolled in a population-based case-control study. Cases tended to have shorter telomeres than controls (P (wilcoxon) = 0.002). Compared to subjects with telomere lengths in the longest tertile, those in the middle and shortest tertiles showed respective age-adjusted odds ratios (95% confidence intervals) of 2.69 (1.23-5.88) and 3.39 (1.54-7.46) (P (trend) = 0.002). Strongest associations were found for subjects with poorly differentiated carcinomas (OR = 4.89, 95% CI 1.93-12.34). This study shows that short leukocyte telomeres are associated with serous ovarian adenocarcinoma. These findings should be confirmed in large, prospective studies. JF - Cancer causes & control : CCC AU - Mirabello, Lisa AU - Garcia-Closas, Montserrat AU - Cawthon, Richard AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Pepłońska, Beata AU - Sherman, Mark E AU - Savage, Sharon A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 77 EP - 82 VL - 21 IS - 1 KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Pilot Projects KW - Middle Aged KW - Genetic Predisposition to Disease KW - Female KW - Leukocytes -- metabolism KW - Telomere -- metabolism KW - Telomere -- chemistry KW - Ovarian Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733512416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Leukocyte+telomere+length+in+a+population-based+case-control+study+of+ovarian+cancer%3A+a+pilot+study.&rft.au=Mirabello%2C+Lisa%3BGarcia-Closas%2C+Montserrat%3BCawthon%2C+Richard%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPep%C5%82o%C5%84ska%2C+Beata%3BSherman%2C+Mark+E%3BSavage%2C+Sharon+A&rft.aulast=Mirabello&rft.aufirst=Lisa&rft.date=2010-01-01&rft.volume=21&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-009-9436-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-13 N1 - Date created - 2010-01-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2000 Oct 31;159(2):175-81 [10996729] J Natl Cancer Inst. 1997 Jul 2;89(13):932-8 [9214672] Gynecol Oncol. 2002 Jan;84(1):81-4 [11748981] Science. 2002 Jul 26;297(5581):565-9 [12142527] J Int Med Res. 2002 May-Jun;30(3):244-50 [12166340] J Natl Cancer Inst. 2003 Aug 20;95(16):1211-8 [12928346] Am J Pathol. 2004 May;164(5):1511-8 [15111296] Br J Haematol. 2004 Jul;126(1):63-71 [15198733] Cancer. 1997 Sep 15;80(6):1085-92 [9305709] Cell. 1997 Oct 3;91(1):25-34 [9335332] Int J Biochem Cell Biol. 2005 May;37(5):1000-13 [15743674] Annu Rev Cell Dev Biol. 2006;22:531-57 [16824017] Clin Cancer Res. 2006 Nov 1;12(21):6345-50 [17085644] Neoplasia. 2007 Jan;9(1):81-9 [17325746] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9 [17416776] BMC Cancer. 2007;7:60 [17411440] Front Biosci. 2007;12:4595-620 [17485399] Cancer Res. 2007 Jun 1;67(11):5538-44 [17545637] J Urol. 2007 Oct;178(4 Pt 1):1492-6 [17707063] Int J Gynecol Pathol. 2008 Apr;27(2):151-60 [18317228] Cancer Sci. 2008 Jul;99(7):1385-9 [18452563] Am J Epidemiol. 2009 Feb 1;169(3):323-9 [19056834] Nucleic Acids Res. 2009 Feb;37(3):e21 [19129229] Hepatology. 2004 Jul;40(1):80-6 [15239089] Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2900-4 [8159676] Nat Genet. 2001 Jun;28(2):155-9 [11381263] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s10552-009-9436-6 ER - TY - JOUR T1 - Unintended hepatic adverse events associated with cancer chemotherapy. AN - 733315043; 19858501 AB - Chemotherapy is meant to be toxic, but it is particularly aimed at the tumor cells. Collateral damage may occur to normal cells and tissues, especially if they are fairly rapidly regenerating, as is the case for bone marrow cells, intestinal epithelial cells, and liver cells after hepatic injury. The liver has a great capacity to resist injury, overcome it, and to regenerate, even after quite massive injury (resection of 50%-65%, for example). This capacity may make it susceptible to chemotherapeutic toxicity, and a struggle between injury and adaptation, leading to recovery and tolerance or to failure and death. If the chemotherapy is aimed just at delaying progression of the cancer for a few weeks or months, it may not be worth the risk of irreversible liver injury developing in that time. Close clinical observation and sound clinical judgment are required. JF - Toxicologic pathology AU - Senior, John R AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. john.senior@fda.hhs.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 142 EP - 147 VL - 38 IS - 1 KW - Antineoplastic Agents KW - 0 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Alanine Transaminase -- blood KW - Humans KW - Neoplasms -- drug therapy KW - Liver -- pathology KW - Liver -- drug effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733315043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Unintended+hepatic+adverse+events+associated+with+cancer+chemotherapy.&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2010-01-01&rft.volume=38&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623309351719 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-05-11 N1 - Date created - 2010-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0192623309351719 ER - TY - JOUR T1 - Arsenic exposure transforms human epithelial stem/progenitor cells into a cancer stem-like phenotype. AN - 733130326; 20056578 AB - Inorganic arsenic is a ubiquitous environmental carcinogen affecting millions of people worldwide. Evolving theory predicts that normal stem cells (NSCs) are transformed into cancer stem cells (CSCs) that then drive oncogenesis. In humans, arsenic is carcinogenic in the urogenital system (UGS), including the bladder and potentially the prostate, whereas in mice arsenic induces multi-organ UGS cancers, indicating that UGS NSCs may represent targets for carcino-genic initiation. However, proof of emergence of CSCs induced by arsenic in a stem cell population is not available. We continuously exposed the human prostate epithelial stem/progenitor cell line WPE-stem to an environmentally relevant level of arsenic (5 microM) in vitro and determined the acquired cancer phenotype. WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hyper-secreting matrix metalloproteinase-9. When hetero-transplanted, these cells (designated As-CSC) formed highly pleomorphic, aggressive tumors with immature epithelial- and mesenchymal-like cells, suggesting a highly pluripotent cell of origin. Consistent with tumor-derived CSCs, As-CSCs formed abundant free-floating spheres enriched in CSC-like cells, as confirmed by molecular analysis and the fact that only these floating cells formed xeno-graft tumors. An early loss of NSC self-renewal gene expression (p63, ABCG2, BMI-1, SHH, OCT-4, NOTCH-1) during arsenite exposure was sub-sequently reversed as the tumor suppressor gene PTEN was progressively suppressed and the CSC-like phenotype acquired. Arsenite transforms prostate epithelial stem/progenitor cells into CSC-like cells, indicating that it can produce CSCs from a model NSC population. JF - Environmental health perspectives AU - Tokar, Erik J AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 108 EP - 115 VL - 118 IS - 1 KW - Arsenites KW - 0 KW - CKAP4 protein, human KW - Carcinogens, Environmental KW - Membrane Proteins KW - PTEN Phosphohydrolase KW - EC 3.1.3.67 KW - PTEN protein, human KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - arsenite KW - N5509X556J KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neoplasms, Experimental -- etiology KW - Humans KW - Neoplasms, Experimental -- genetics KW - Arsenites -- toxicity KW - Prostate -- metabolism KW - Neoplasms, Experimental -- metabolism KW - Mice KW - Mice, Nude KW - Membrane Proteins -- genetics KW - Neoplasms, Experimental -- pathology KW - PTEN Phosphohydrolase -- genetics KW - Phenotype KW - Matrix Metalloproteinase 9 -- metabolism KW - Transplantation, Heterologous KW - Prostate -- cytology KW - Spheroids, Cellular -- pathology KW - Cell Line KW - Male KW - Cell Transformation, Neoplastic -- pathology KW - Arsenic -- toxicity KW - Neoplastic Stem Cells -- pathology KW - Adult Stem Cells -- drug effects KW - Adult Stem Cells -- metabolism KW - Cell Transformation, Neoplastic -- drug effects KW - Neoplastic Stem Cells -- transplantation KW - Carcinogens, Environmental -- toxicity KW - Adult Stem Cells -- pathology KW - Cell Transformation, Neoplastic -- genetics KW - Neoplastic Stem Cells -- metabolism KW - Neoplastic Stem Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733130326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Arsenic+exposure+transforms+human+epithelial+stem%2Fprogenitor+cells+into+a+cancer+stem-like+phenotype.&rft.au=Tokar%2C+Erik+J%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Tokar&rft.aufirst=Erik&rft.date=2010-01-01&rft.volume=118&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.0901059 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-03 N1 - Date created - 2010-01-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2000 Feb 18;100(4):387-90 [10693755] Nature. 2006 Aug 17;442(7104):818-22 [16862118] Nat Med. 2001 Sep;7(9):1028-34 [11533706] BJU Int. 2001 Sep;88 Suppl 2:35-42; discussion 49-50 [11589668] Nature. 2001 Nov 1;414(6859):105-11 [11689955] Prostate. 2002 Jan 1;50(1):46-53 [11757035] Environ Health Perspect. 2002 Apr;110(4):331-6 [11940449] J Clin Pathol. 2002 May;55(5):321-5 [11986333] Nat Rev Cancer. 2002 May;2(5):361-72 [12044012] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nature. 2003 May 15;423(6937):255-60 [12714970] Genes Dev. 2003 May 15;17(10):1253-70 [12756227] Nat Rev Cancer. 2003 Jun;3(6):434-43 [12778133] Urology. 2003 Nov;62(5 Suppl 1):11-20 [14607213] Nat Rev Cancer. 2003 Dec;3(12):895-902 [14737120] J Cell Physiol. 2004 Apr;199(1):126-33 [14978741] Trends Genet. 1993 Apr;9(4):138-41 [8516849] Nat Med. 1997 Jul;3(7):730-7 [9212098] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Science. 1999 Apr 30;284(5415):770-6 [10221902] Nature. 2004 Nov 18;432(7015):396-401 [15549107] Cell. 2005 May 6;121(3):465-77 [15882627] Semin Cancer Biol. 2007 Jun;17(3):219-24 [16781871] Semin Cancer Biol. 2007 Jun;17(3):204-13 [16787749] Semin Cancer Biol. 2007 Jun;17(3):189-90 [16806966] Cell. 2007 May 4;129(3):523-36 [17482546] Toxicol Appl Pharmacol. 2007 May 15;221(1):119-28 [17400267] Stem Cells. 2007 Jul;25(7):1645-53 [17412894] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] Environ Health Perspect. 2008 Feb;116(2):158-64 [18288312] Cell. 2008 Feb 22;132(4):681-96 [18295583] Cell Stem Cell. 2008 Apr 10;2(4):333-44 [18397753] Differentiation. 2008 Jul;76(6):699-716 [18565101] Cancer Res. 2008 Oct 15;68(20):8278-85 [18922899] Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):268-73 [19116269] Cancer Res. 2005 Jul 1;65(13):5506-11 [15994920] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Cancer Res. 2005 Aug 1;65(15):6640-50 [16061644] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11355-60 [16051706] Differentiation. 2005 Dec;73(9-10):463-73 [16351690] Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):111-6 [16373498] Nature. 2006 Feb 23;439(7079):993-7 [16395311] Nature. 2006 May 25;441(7092):475-82 [16598206] Nature. 2006 May 25;441(7092):518-22 [16633340] Environ Health Perspect. 2006 Aug;114(8):1293-6 [16882542] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1289/ehp.0901059 ER - TY - RPRT T1 - Head Start Impact Study. Final Report. Executive Summary AN - 61820133; ED507847 AB - This report summarizes the findings from a study on the impacts of Head Start on children and families during the children's preschool, kindergarten, and 1st grade years. Its study goals were to: (1) Determine the impact of Head Start on children's school readiness, and on parental practices that support children's development; and to (2) determine under what circumstances Head Start achieves its greatest impact and for which children. (Contains 10 exhibits and 14 footnotes.) [For the "Head Start Impact Study. Final Report," see ED507845. For the "Head Start Impact Study. Technical Report," see ED507846.] AU - Puma, Michael AU - Bell, Stephen AU - Cook, Ronna AU - Heid, Camilla AU - Shapiro, Gary AU - Broene, Pam AU - Jenkins, Frank AU - Fletcher, Philip AU - Quinn, Liz AU - Friedman, Janet AU - Ciarico, Janet AU - Rohacek, Monica AU - Adams, Gina AU - Spier, Elizabeth Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 35 PB - Administration for Children & Families. US Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Grade 1 KW - Kindergarten KW - Preschool Education KW - Context Effect KW - Program Effectiveness KW - Research Reports KW - Low Income Groups KW - Measures (Individuals) KW - Young Children KW - National Programs KW - Exhibits KW - Research Design KW - Outcomes of Education KW - Advisory Committees KW - Holistic Approach KW - Human Services KW - Computation KW - Grade 3 KW - Early Intervention KW - Disadvantaged Youth KW - Preschool Children KW - School Readiness KW - Educational Research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61820133?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Head Start Impact Study. Technical Report AN - 61819286; ED507846 AB - This Technical Report is designed to provide technical detail to support the analysis and findings presented in the "Head Start Impact Study Final Report" (U.S. Department of Health and Human Services, January 2010). Chapter 1 provides an overview of the Head Start Impact Study and its findings. Chapter 2 provides technical information on the analytical sampling weights used in the analysis. A description of the outcome measures and their psychometric properties is provided in Chapter 3 and the description of the data collection procedures is provided in Chapter 4. Chapter 5 provides a description of the impact analysis methods including ITT (intent-to-treat) impact estimates, IOT (impact on the treated) impact estimates, and subgroup impact estimates. (Contains 49 exhibits and 50 footnotes.) [For the "Head Start Impact Study. Final Report," see ED507845. For the "Head Start Impact Study. Final Report. Executive Summary," see ED507847.] AU - Puma, Michael AU - Bell, Stephen AU - Cook, Ronna AU - Heid, Camilla AU - Shapiro, Gary AU - Broene, Pam AU - Jenkins, Frank AU - Fletcher, Philip AU - Quinn, Liz AU - Friedman, Janet AU - Ciarico, Janet AU - Rohacek, Monica AU - Adams, Gina AU - Spier, Elizabeth Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 207 PB - Administration for Children & Families. US Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Research Reports KW - Program Effectiveness KW - Research Methodology KW - Psychometrics KW - Outcomes of Education KW - Computation KW - Kindergarten KW - Disadvantaged Youth KW - Data Collection KW - Program Evaluation KW - Preschool Children KW - School Readiness KW - Context Effect KW - Low Income Groups KW - Measures (Individuals) KW - National Programs KW - Exhibits KW - Holistic Approach KW - Human Services KW - Grade 3 KW - Technical Writing KW - Grade 1 KW - Early Intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61819286?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - GEN T1 - Head Start Impact Study. Final Report AN - 61814923; ED507845 AB - This report addresses the following four questions by reporting on the impacts of Head Start on children and families during the children's preschool, kindergarten, and 1st grade years: (1) What difference does Head Start make to key outcomes of development and learning (and in particular, the multiple domains of school readiness) for low-income children? (2) What difference does Head Start make to parental practices that contribute to children's school readiness? (3) Under what circumstances does Head Start achieve the greatest impact? What works for which children? (4) What Head Start services are most related to impact? The Head Start Impact Study was conducted with a nationally representative sample of 84 grantee/delegate agencies and included nearly 5,000 newly entering, eligible 3- and 4-year-old children who were randomly assigned to either: (1) a Head Start group that had access to Head Start program services or (2) a control group that did not have access to Head Start, but could enroll in other early childhood programs or non-Head Start services selected by their parents. The study was designed to separately examine two cohorts of children, newly entering 3-and 4-year-olds. This design reflects the hypothesis that different program impacts may be associated with different age of entry into Head Start. Differential impacts are of particular interest in light of a trend of increased enrollment of the 3-year-olds in some grantee/delegate agencies presumably due to the growing availability of preschool options for 4-year-olds. Consequently, the study included two separate samples: a newly entering 3-year-old group (to be studied through two years of Head Start participation i.e., Head Start year and age 4 year, kindergarten and 1st grade), and a newly entering 4-year-old group (to be studied through one year of Head Start participation, kindergarten and 1st grade). The study showed that the two age cohorts varied in demographic characteristics, making it even more appropriate to examine them separately. The racial/ethnic characteristics of newly entering children in the 3-year-old cohort were substantially different from the characteristics of children in the newly entering 4-year-old cohort. While the newly entering 3-year-olds were relatively evenly distributed between Black children and Hispanic children (Black children 32.8%, Hispanic children 37.4%, and White/other children 29.8%), about half of newly entering 4-year-olds were Hispanic children (Black children 17.5%, Hispanic children 51.6%, and White/other children 30.8%). The ethnic difference is also reflected in the age-group differences in child and parent language. This report presents the findings from the preschool years through children's 1st grade experience. This document consists of the Executive Summary and nine chapters. Chapter 1 presents the study background, including a literature review of related Head Start research and the study purpose and objectives. Chapter 2 provides details about the study design and implementation. It discusses the experimental design, sample selection prior to random assignment, data collection, and data analysis. To provide a context in which to understand the impact findings, Chapter 3 examines the impact of Head Start on the services and child care settings that children experience prior to starting school. It also provides the impact of Head Start on the educational and child care settings, setting characteristics, and services that children experience during kindergarten and 1st grade. Chapters 4 through 7 present the impact of Head Start on children's outcomes and parenting practices for the years before school and then for kindergarten and 1st grade. Chapter 4 presents the impact of Head Start on children's cognitive development, Chapter 5 presents the impact of Head Start on children's social-emotional development, Chapter 6 presents the impact of Head Start on children's health status and access to health services, and Chapter 7 presents the impact of Head Start on parenting practices in the areas of educational activities, discipline practices, and school involvement. Chapter 8 examines variation in impacts by child characteristics, parent and family characteristics, and community characteristics. Chapter 9 provides an overall summary of the findings, implications for the Head Start Program, and unanswered questions. Appendices in this volume include the Head Start Impact Study legislation, a list of the official Head Start Impact Study Advisory Committee members, the language decision form used to determine the language in which the child was assessed, and data tables that elaborate on the findings presented in the volume (e.g., Impact on Treated (IOT) findings). The findings from a sample of programs in Puerto Rico are also provided in an appendix. Programs in Puerto Rico were included in the study with the intent that data on children in these programs would be analyzed along with the data on children in the 50 states and the District of Columbia, once children reached school-age. (Contains 1 figure, 117 footnotes, and 114 exhibits.) [The ERIC version of this document contains the following supplementary materials: Head Start Impact Study Main Impact Tables, 2003 through 2006; and Head Start Impact Study Subgroup Impact Tables, 2003 through 2006. For the "Head Start Impact Study Technical Report," see ED507846. For the "Head Start Impact Study Final Report. Executive Summary," see ED507847.] AU - Puma, Michael AU - Bell, Stephen AU - Cook, Ronna AU - Heid, Camilla AU - Shapiro, Gary AU - Broene, Pam AU - Jenkins, Frank AU - Fletcher, Philip AU - Quinn, Liz AU - Friedman, Janet AU - Ciarico, Janet AU - Rohacek, Monica AU - Adams, Gina AU - Spier, Elizabeth Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 611 PB - Administration for Children & Families. US Department of Health and Human Services, 380 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Grade 1 KW - Grade 3 KW - Kindergarten KW - Preschool Education KW - Family Characteristics KW - Program Effectiveness KW - Low Income Groups KW - National Programs KW - Research Design KW - Outcomes of Education KW - Advisory Committees KW - Holistic Approach KW - Health Services KW - African American Children KW - Control Groups KW - Early Intervention KW - Disadvantaged Youth KW - Program Evaluation KW - Preschool Children KW - School Readiness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61814923?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Administration for Children and Families: Head Start AN - 61807762; ED507835 AB - This paper presents an overview of the Head Start program. Under the American Recovery and Reinvestment Act (Recovery Act), $1 billion will be provided to the Office of Head Start to promote the school readiness of low-income children, including children on federally-recognized reservations and children of migratory farm workers, by enhancing their cognitive, social and emotional development of low-income children, through the provision of comprehensive health, educational, nutritional, social and other services and to involve parents in their children's learning and to help parents make progress toward their educational, literacy and employment goals. Head Start also emphasizes the significant involvement of parents in the administration of their local Head Start programs. This overview provides the following information relating to the Head Start program: (1) Funding Table; (2) Objectives; (3) Activities; (4) Characteristics; (5) Delivery Schedule; (6) Environmental Review Compliance; (7) Measures; (8) Monitoring and Evaluation; (9) Transparency; (10) Accountability; (11) Barriers to Effective Implementation; and (12) Federal Infrastructure. (Contains 2 tables.) Y1 - 2010 PY - 2010 DA - 2010 SP - 6 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Program Descriptions KW - Low Income KW - Accountability KW - Holistic Approach KW - Economic Opportunities KW - Money Management KW - Federal Legislation KW - Profiles KW - Federal Programs KW - Parent Participation KW - Child Development KW - Early Intervention KW - Disadvantaged Youth KW - Preschool Children KW - School Readiness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61807762?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - RPRT T1 - Administration for Children and Families: Early Head Start AN - 61807327; ED507826 AB - This paper presents an overview of the Early Head Start program. The objective of the Early Head Start program is to enhance the cognitive, social and emotional development of low-income children, including children on federally-recognized reservations and children of migratory farm workers, through the provision of comprehensive health, educational, nutritional, social and other services and to involve parents in their children's learning and to help parents make progress toward their educational, literacy and employment goals. Head Start also emphasizes the significant involvement of parents in the administration of their local Head Start programs. This overview provides the following as they relate to the Early Head Start program: (1) Funding Table; (2) Objectives; (3) Activities; (4) Characteristics; (5) Delivery Schedule; (6) Environmental Review Compliance; (7) Measures; (8) Monitoring and Evaluation; (9) Transparency; (10) Accountability; (11) Barriers to Effective Implementation; and (12) Federal Infrastructure. (Contains 2 tables.) Y1 - 2010 PY - 2010 DA - 2010 SP - 5 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Financial Support KW - American Indian Reservations KW - Barriers KW - Cognitive Development KW - Educational Legislation KW - Educational Administration KW - Educational Objectives KW - Educational Finance KW - Emotional Development KW - Federal Programs KW - Program Implementation KW - Parent Participation KW - Disadvantaged Youth KW - Social Development KW - Program Evaluation KW - Migrant Children KW - Preschool Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61807327?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER - TY - JOUR T1 - New State Strategies To Meet Long-Term Care Needs AN - 58843539; 2010-483821 AB - Consumer-directed long-term care service programs give participants the flexibility they want, while reducing unmet need for home and community-based services and supports. States' efforts to expand such programs under Medicaid, including those supported by federal Cash and Counseling demonstration and evaluation grants, are often hindered by challenges related to costs, staffing and organizational issues, new infrastructure requirements, and resistance from stakeholders. Yet states have developed a number of successful strategies for overcoming these challenges, even in financially trying times. Their experiences offer valuable insights, guidance, and encouragement to other states contemplating consumer-directed service expansions. Adapted from the source document. JF - Health Affairs AU - Doty, Pamela AU - Mahoney, Kevin J AU - Sciegaj, Mark AD - Department of Health and Human Services, Washington, D.C Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 49 EP - 56 PB - Project HOPE, Bethesda MD VL - 29 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Medicine and health care KW - Population groups, population policy, and demographics - Demography and census KW - Health conditions and policy - Health and health policy KW - Social conditions and policy - Public welfare and social services KW - Social conditions and policy - Housing KW - Social conditions and policy - Psychology KW - Medicaid program KW - Long-term care of the sick KW - Old age KW - Counseling KW - Medical service KW - Assisted living KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58843539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=New+State+Strategies+To+Meet+Long-Term+Care+Needs&rft.au=Doty%2C+Pamela%3BMahoney%2C+Kevin+J%3BSciegaj%2C+Mark&rft.aulast=Doty&rft.aufirst=Pamela&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2009.0521 LA - English DB - PAIS Index N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Long-term care of the sick; Medical service; Old age; Medicaid program; Assisted living; Counseling DO - http://dx.doi.org/10.1377/hlthaff.2009.0521 ER - TY - JOUR T1 - Health Spending Growth At A Historic Low In 2008 AN - 58843293; 2010-483832 AB - In 2008, U.S. health care spending growth slowed to 4.4 percent-the slowest rate of growth over the past forty-eight years. The deceleration was broadly based for nearly all payers and health care goods and services, as growth in both price and nonprice factors slowed amid the recession. Despite the slowdown, national health spending reached $2.3 trillion, or $7,681 per person, and the health care portion of gross domestic product (GDP) grew from 15.9 percent in 2007 to 16.2 percent in 2008. These developments reflect the general pattern that larger increases in the health spending share of GDP generally occur during or just after periods of economic recession. Despite the overall slowdown in national health spending growth, increases in this spending continue to outpace growth in the resources available to pay for it. Adapted from the source document. JF - Health Affairs AU - Hartman, Micah AU - Martin, Anne AU - Nuccio, Olivia AU - Catlin, Aaron AD - Centers for Medicare and Medicaid Services (CMS) Office of the Actuary, Baltimore, Maryland micah.hartman@cms.hhs.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 147 EP - 155 PB - Project HOPE, Bethesda MD VL - 29 IS - 1 SN - 0278-2715, 0278-2715 KW - Health conditions and policy - Health and health policy KW - Business and service sector - Insurance KW - Economic conditions and policy - Economic theory KW - Business and service sector - Business finance KW - Cost KW - United States KW - Prices KW - Appropriations and expenditures KW - Health insurance KW - Health policy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58843293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Affairs&rft.atitle=Health+Spending+Growth+At+A+Historic+Low+In+2008&rft.au=Hartman%2C+Micah%3BMartin%2C+Anne%3BNuccio%2C+Olivia%3BCatlin%2C+Aaron&rft.aulast=Hartman&rft.aufirst=Micah&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Health+Affairs&rft.issn=02782715&rft_id=info:doi/10.1377%2Fhlthaff.2009.0839 LA - English DB - PAIS Index N1 - Date revised - 2010-04-07 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Health policy; Appropriations and expenditures; United States; Health insurance; Cost; Prices DO - http://dx.doi.org/10.1377/hlthaff.2009.0839 ER - TY - JOUR T1 - Collaboration for the Integration of HIV Prevention at Title X Family Planning Service Delivery Sites AN - 58839380; 2008-461937 AB - Since 2001, the U.S. Department of Health and Human Services' Office of Family Planning (OFP), in collaboration with the Minority AIDS Initiative, has provided supplemental grant funds to Title X-funded family planning service delivery sites to expand the availability of human immunodeficiency virus (HIV) prevention services. This work has resulted in three major outcomes: (7) increased institutional capacity for the delivery of HIV-prevention services at Title X family planning service delivery sites, (2) the successful implementation of HIV-prevention services at these sites, and (3) the identification of HIV-positive individuals who were referred to care services. These efforts resulted in a total of 539,667 unduplicated individuals being tested for HIV. These tests resulted in the identification of 1,692 HIV-positive individuals who otherwise may not have been tested for HIV. More than 85% of the HIV-positive cases were detected among clients who self-identified as members of racial/ethnic minority groups. The integration of HIV-prevention services is a feasible and effective strategy for detecting HIV infection among women, including women in racial/ethnic minority groups. Adapted from the source document. JF - Public Health Reports AU - Tran, Nhan T AU - Hallerdin, Jule M AU - Flowers-Maple, Charon AU - Moskosky, Susan B AD - Office of Family Planning, Office of Population Affairs, U.S. Department of Health and Human Services,1101 Wootton Pkwy., Ste. 700, Rockville, MD 21852; tel.: 240-453-2888; fax: 240-453-2819 Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 47 EP - 54 PB - Oxford University Press, UK VL - 125 SN - 0033-3549, 0033-3549 KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Medicine and health care KW - Population groups, population policy, and demographics - Family planning KW - Population groups, population policy, and demographics - National, ethnic, and minority groups KW - Family planning KW - Acquired immune deficiency syndrome KW - United States Health and human services department KW - Minorities KW - Human immunodeficiency virus KW - Medical service KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58839380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Reports&rft.atitle=Collaboration+for+the+Integration+of+HIV+Prevention+at+Title+X+Family+Planning+Service+Delivery+Sites&rft.au=Tran%2C+Nhan+T%3BHallerdin%2C+Jule+M%3BFlowers-Maple%2C+Charon%3BMoskosky%2C+Susan+B&rft.aulast=Tran&rft.aufirst=Nhan&rft.date=2010-01-01&rft.volume=125&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Public+Health+Reports&rft.issn=00333549&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2010-03-05 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Medical service; Family planning; Minorities; United States Health and human services department; Acquired immune deficiency syndrome ER - TY - JOUR T1 - Analytical Methodology and Assessment of Potential Second-Hand Exposure to Fentanyl in the Hospital Surgical Setting AN - 57355522; 201007396 AB - Second-hand exposure to aerosols containing fentanyl and other opiates during surgical procedures has been implicated as possibly contributing to maintenance of addiction among medical professionals, specifically anesthesiologists. This article outlines a pilot study that was conducted to verify a reported finding fentanyl in the air of operating suites. Environmental fentanyl air sampling and analysis methods were developed and evaluated for this study. Multiple sampling media and extraction solvents were evaluated for trace fentanyl air sampling. Non-specific binding losses were reduced by using silanized binder-free glass fiber sampling media with subsequent methanol extraction. Filtration air samples were then collected in surgical suites during the entire operation time from two cardiovascular surgical procedures. Both surgical procedures were conducted at the same hospital but on different days. Samples were extracted and analyzed by high-performance liquid chromatography/tandem mass spectrometry using a capillary high-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. The total air volume collected per surgery was 290 to 300 L at a rate of 1 LPM giving an limit of quantification for fentanyl of 57 pg/m3 air (17 pg/filter). No fentanyl was detected in the air during cardiovascular surgical operations from either surgical suite. Adapted from the source document. JF - Journal of Addictive Diseases AU - Law, Brandon F AU - Hettick, Justin M AU - Hornsby-Myers, Jennifer AU - Siegel, Paul D AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 51 EP - 58 PB - Taylor & Francis, Philadelphia PA VL - 29 IS - 1 SN - 1055-0887, 1055-0887 KW - Extraction KW - Surgery KW - Sampling KW - Liquids KW - Spectrometry KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57355522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Analytical+Methodology+and+Assessment+of+Potential+Second-Hand+Exposure+to+Fentanyl+in+the+Hospital+Surgical+Setting&rft.au=Law%2C+Brandon+F%3BHettick%2C+Justin+M%3BHornsby-Myers%2C+Jennifer%3BSiegel%2C+Paul+D&rft.aulast=Law&rft.aufirst=Brandon&rft.date=2010-01-01&rft.volume=29&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1080%2F10550880903438933 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Sampling; Liquids; Hospitals; Extraction; Spectrometry; Surgery DO - http://dx.doi.org/10.1080/10550880903438933 ER - TY - JOUR T1 - Impact of Local Resources on Hospitalization Patterns of Medicare Beneficiaries and Propensity to Travel Outside Local Markets AN - 57340492; 201006063 AB - Purpose: To examine how local health care resources impact travel patterns of patients age 65 and older across the rural urban continuum. Methods: Information on inpatient hospital discharges was drawn from complete 2004 hospital discharge files from the Healthcare Cost and Utilization Project (HCUP) State Inpatient Databases (SID) for New York, California, and Florida, and the 2003 hospital discharge file for Pennsylvania. The study population was Medicare patients with admissions for ambulatory care sensitive conditions. Analysis was at the patient-level, and area contextual variables were developed at the Primary Care Service Area (PCSA) level. Local resources considered included inpatient supply, provider supply, supply of international medical graduates, and critical access hospitals (CAHs) in the patient's PCSA. Findings: Findings generally confirmed enhanced retention of the elderly in local markets with greater availability of community resources, although we observed considerable heterogeneity across states. Community resource variables such as median household income or inpatient hospital capacity were stronger and more consistent predictors along the urban rural continuum than any of the provider or CAH variables. Only in California and New York did we see significant effects for provider supply or CAH, but they were robust across the 2 states and models of travel propensity, always reducing the travel propensity. Conclusions: Findings support policies aimed at augmenting supplies of critical access hospitals in rural communities, and increasing primary care physicians and hospital resources in both rural and urban communities. Adapted from the source document. JF - The Journal of Rural Health AU - Basu, Jayasree AU - Mobley, Lee R AD - Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland Jayasree.basu@ahrq.hhs.gov Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 20 EP - 29 PB - National Rural Health Association, Kansas City MO VL - 26 IS - 1 SN - 0890-765X, 0890-765X KW - Discharge KW - Hospitalization KW - Medicare KW - Markets KW - Rural communities KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57340492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Impact+of+Local+Resources+on+Hospitalization+Patterns+of+Medicare+Beneficiaries+and+Propensity+to+Travel+Outside+Local+Markets&rft.au=Basu%2C+Jayasree%3BMobley%2C+Lee+R&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2010-01-01&rft.volume=26&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2009.00261.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-10-21 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Hospitals; Hospitalization; Rural communities; Markets; Discharge; Medicare DO - http://dx.doi.org/10.1111/j.1748-0361.2009.00261.x ER - TY - JOUR T1 - Pharmacometrics-Based Dose Selection of Levofloxacin as a Treatment for Postexposure Inhalational Anthrax in Children AN - 21506167; 12492403 AB - Levofloxacin was recently (May 2008) approved by the U.S. Food and Drug Administration as a treatment for children following inhalational exposure to anthrax. Given that no clinical trials to assess the efficacy of a chosen dose was conducted, the basis for the dose recommendation was based upon pharmacometric analyses. The objective of this paper is to describe the basis of the chosen pediatric dose recommended for the label. Pharmacokinetic (PK) data from 90 pediatric patients receiving 7 mg/kg of body weight levofloxacin and two studies of 47 healthy adults receiving 500 and 750 mg/kg levofloxacin were used for the pharmacometric analyses. Body weight was found to be a significant covariate for levofloxacin clearance and the volume of distribution. Consistently with developmental physiology, clearance also was found to be reduced in pediatric patients under 2 years of age due to immature renal function. Different dosing regimens were simulated to match adult exposure (area under the concentration-time curve from 0 to 24 h at steady state, maximum concentration of drug in serum at steady state, and minimum concentration of drug in serum at steady state) following the approved adult dose of 500 mg once a day. The recommended dose of 8 mg/kg twice a day was found to match the exposure of the dose approved for adults in a manner that permitted confidence that this dose in children would achieve efficacy comparable to that of adults. JF - Antimicrobial Agents & Chemotherapy AU - Li, Fang AU - Nandy, Partha AU - Chien, Shuchean AU - Noel, Gary J AU - Tornoe, Christoffer W Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 375 EP - 379 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 54 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Toxicology Abstracts KW - Age KW - Data processing KW - Body weight KW - Renal function KW - Pediatrics KW - Levofloxacin KW - Anthrax KW - Children KW - Clinical trials KW - Pharmacokinetics KW - X 24370:Natural Toxins KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21506167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacometrics-Based+Dose+Selection+of+Levofloxacin+as+a+Treatment+for+Postexposure+Inhalational+Anthrax+in+Children&rft.au=Li%2C+Fang%3BNandy%2C+Partha%3BChien%2C+Shuchean%3BNoel%2C+Gary+J%3BTornoe%2C+Christoffer+W&rft.aulast=Li&rft.aufirst=Fang&rft.date=2010-01-01&rft.volume=54&rft.issue=1&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00667-09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Renal function; Body weight; Pediatrics; Levofloxacin; Anthrax; Children; Clinical trials; Pharmacokinetics DO - http://dx.doi.org/10.1128/AAC.00667-09 ER - TY - JOUR T1 - A century of mining safety and health research AN - 21321104; 11912780 AB - The year 2010 will mark the 100th anniversary of the beginning of the research efforts by the U.S. government to improve the health and safety of miners working in the United States. This research began in 1910 with the establishment of the U.S. Bureau of Mines (the Bureau) and it has continued during the past 10 decades, even after the closure of the Bureau in 1996. The research on safer mining technology, formerly done by the Bureau, has now been combined with National Institute for Occupational Safety and Health (NIOSH) studies of miners' health to form a unified federal research program to improve the health and safety of miners. This article describes this research and places some of the accomplishments into perspective with other activities in the U.S. Mine Safety and Health Time Line (insert). JF - Mining Engineering AU - Breslin, JA AD - NIOSH, Pittsburgh, PA, USA, jbreslin@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 33 EP - 37 PB - Society for Mining, Metallurgy and Exploration, 8307 Shaffer Parkway Littleton CO 80127-5002 USA VL - 62 IS - 1 SN - 0026-5187, 0026-5187 KW - Health & Safety Science Abstracts KW - Historical account KW - Occupational safety KW - USA KW - safety engineering KW - Mining KW - Research programs KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21321104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mining+Engineering&rft.atitle=A+century+of+mining+safety+and+health+research&rft.au=Breslin%2C+JA&rft.aulast=Breslin&rft.aufirst=JA&rft.date=2010-01-01&rft.volume=62&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Mining+Engineering&rft.issn=00265187&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; safety engineering; Historical account; Mining; Occupational safety; Research programs; Technology ER - TY - JOUR T1 - Survival of secondary lethal systemic Francisella LVS challenge depends largely on interferon gamma AN - 21307662; 12522553 AB - Although survival of primary infection with the live vaccine strain (LVS) of Francisella tularensis depends on interferon gamma (IFN-g), the relative importance of IFN-g to secondary protective immunity in vivo has not been clearly established. Here we examine the role of IFN-g in T cell priming and expression of vaccine-induced protection against lethal intraperitoneal challenge of mice. Large amounts of IFN-g were detected between days 3 and 7 in the sera of LVS-immunized mice, while relatively small amounts were found transiently after secondary LVS challenge. Consistent with the production of this cytokine, mice lacking IFN-g (gamma interferon knockout, GKO, mice) could not be successfully vaccinated with LVS or an attenuated mglA mutant of F. novicida to withstand secondary Francisella LVS challenge. Further, splenocytes from such primed mice did not adoptively transfer protection to naive GKO recipient mice in vivo, nor control the intramacrophage growth of LVS in vitro. Finally, LVS-immune WT mice depleted of IFN-g prior to intraperitoneal challenge survived only the lowest doses of challenge. Thus successful priming of protective LVS-immune T cells, as well as complete expression of protection against Francisella during secondary challenge, depends heavily on IFN-g. JF - Microbes and Infection AU - Elkins, Karen L AU - Colombini, Susan M AU - Meierovics, Anda I AU - Chu, May C AU - Chou, Alicia Y AU - Cowley, Siobhan C AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic, and Allergenic Products, CBER/FDA, 1401 Rockville Pike, HFM 431, Rockville, MD 20852, USA, karen.elkins@fda.hhs.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 28 EP - 36 PB - Editions Scientifiques et Medicales Elsevier, 23 rue Linois 75724 Paris cedex 15 France VL - 12 IS - 1 SN - 1286-4579, 1286-4579 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Infection KW - Lymphocytes T KW - Splenocytes KW - Survival KW - Vaccination KW - Vaccines KW - g-Interferon KW - Francisella tularensis KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21307662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbes+and+Infection&rft.atitle=Survival+of+secondary+lethal+systemic+Francisella+LVS+challenge+depends+largely+on+interferon+gamma&rft.au=Elkins%2C+Karen+L%3BColombini%2C+Susan+M%3BMeierovics%2C+Anda+I%3BChu%2C+May+C%3BChou%2C+Alicia+Y%3BCowley%2C+Siobhan+C&rft.aulast=Elkins&rft.aufirst=Karen&rft.date=2010-01-01&rft.volume=12&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Microbes+and+Infection&rft.issn=12864579&rft_id=info:doi/10.1016%2Fj.micinf.2009.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2013-05-06 N1 - SubjectsTermNotLitGenreText - Splenocytes; g-Interferon; Lymphocytes T; Survival; Vaccines; Infection; Vaccination; Francisella tularensis DO - http://dx.doi.org/10.1016/j.micinf.2009.09.012 ER - TY - JOUR T1 - Thermal effects generated by high-intensity focused ultrasound beams at normal incidence to a bone surface AN - 21303563; 12340160 AB - Experiments and computations were performed to study factors affecting thermal safety when high-intensity focused ultrasound (HIFU) beams are normally incident (i.e., beam axis normal to the interface) upon a bone/soft-tissue interface. In particular, the temperature rise and thermal dose were determined as a function of separation between the beam focus and the interface. Under conditions representative of clinical HIFU procedures, it was found that the thermal dose at the bone surface can exceed the threshold for necrosis even when the beam focus is more than 4 cm from the bone. Experiments showed that reflection of the HIFU beam from the bone back into the transducer introduced temperature fluctuations of as much as c15% and may be an important consideration for safety analyses at sufficiently high acoustic power. The applicability of linear propagation models in predicting thermal dose near the interface was also addressed. Linear models, while underpredicting thermal dose at the focus, provided a conservative (slight overprediction) estimate of thermal dose at the bone surface. Finally, temperature rise due to absorption of shear waves generated by the HIFU beam in the bone was computed. Modeling shear-wave propagation in the thermal analysis showed that the predicted temperature rise off axis was as much as 30% higher when absorption of shear waves is included, indicating that enhanced heating due to shear-wave absorption is potentially important, even for normally incident HIFU beams. JF - Journal of the Acoustical Society of America AU - Nell, D M AU - Myers, M R AD - Center for Devices and Radiological Health, U.S. Food and Drug Administration, Building 62, 10902 New Hampshire Avenue, Silver Spring, Maryland 20993, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 549 EP - 559 PB - Acoustical Society of America, Suite 1NO1 2 Huntington Quadrangle Melville NY 11747-4502 USA, [mailto:asa@aip.org], [URL:http://asa.aip.org/] VL - 127 IS - 1 SN - 0001-4966, 0001-4966 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Bone KW - Temperature effects KW - Necrosis KW - Acoustics KW - Waves KW - Ultrasound KW - Models KW - W 30910:Imaging KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21303563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Acoustical+Society+of+America&rft.atitle=Thermal+effects+generated+by+high-intensity+focused+ultrasound+beams+at+normal+incidence+to+a+bone+surface&rft.au=Nell%2C+D+M%3BMyers%2C+M+R&rft.aulast=Nell&rft.aufirst=D&rft.date=2010-01-01&rft.volume=127&rft.issue=1&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Acoustical+Society+of+America&rft.issn=00014966&rft_id=info:doi/10.1121%2F1.3257547 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Temperature effects; Bone; Necrosis; Acoustics; Waves; Ultrasound; Models DO - http://dx.doi.org/10.1121/1.3257547 ER - TY - JOUR T1 - Mycobacteria isolated from Chesapeake Bay fish AN - 21262273; 11838096 AB - AbstractMycobacteriosis in fish can result in ulcers, emaciation, and in some cases death. Mycobacteria have been previously isolated from a variety of Chesapeake Bay fish species, and the current study was designed to identify potential host specificity and location fidelity of mycobacterial isolates. Mycobacteria were isolated from wild fish of the Chesapeake Bay collected from the Upper Bay, the Choptank River, Herring Bay, the Chicamacomico River, the Pocomoke River and the Potomac River in 2003-2006. Mycobacterial isolates were recovered from striped bass, Morone saxatilis, Atlantic menhaden, Brevoortia tyrannus, white perch, Morone americana, summer flounder, Paralichthys dentatus, spot, Leiostomus xanthurus, largemouth bass, Micropterus salmoides, channel catfish, Ictalurus punctatus, common carp, Cyprinus carpio carpio, spotted seatrout, Cynoscion nebulosus, killifish, Fundulus sp., blueback herring, Alosa aestivalis, American gizzard shad, Dorosoma cepedianum and American silver perch, Bairdiella chrysoura. Twenty-nine well-defined mycobacterial groups resulted from gas chromatography dendrogram clustering of isolates. The majority of groups included more than one host species and more than one site of collection. However, four groups contained only striped bass isolates, three of which were similar to M. shottsii. Therefore, multiple Chesapeake Bay fish species are colonized with multiple mycobacterial isolates, of which few appear to be host or location specific. JF - Journal of Fish Diseases AU - Stine, C B AU - Kane, A S AU - Baya, A M AD - US Food and Drug Administration, Center for Veterinary Medicine, Laurel, MD, USA Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 39 EP - 46 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 33 IS - 1 SN - 0140-7775, 0140-7775 KW - ASFA Aquaculture Abstracts; Microbiology Abstracts B: Bacteriology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Atlantic menhaden KW - Chesapeake Bay KW - mycobacteria KW - striped bass KW - white perch KW - Micropterus salmoides KW - Chromatographic techniques KW - Pelagic fisheries KW - Paralichthys dentatus KW - USA, Maryland, Choptank R. KW - Hosts KW - Freshwater KW - Freshwater fish KW - Ictalurus punctatus KW - Marine fish KW - Morone americana KW - Gas chromatography KW - Bairdiella chrysoura KW - USA, Maryland, Potomac R. KW - Brackishwater environment KW - Leiostomus xanthurus KW - Diseases KW - Rivers KW - Brevoortia tyrannus KW - Host specificity KW - Dorosoma cepedianum KW - Cynoscion nebulosus KW - Estuaries KW - Brackish KW - ANW, USA, Chesapeake Bay KW - USA, Maryland, Pocomoke R. KW - INE, USA, Alaska, Alaska Gulf, Prince William Sound, Herring Bay KW - Fidelity KW - Morone saxatilis KW - fish diseases KW - Fish diseases KW - Cyprinus carpio KW - Ulcers KW - Cyprinus carpio carpio KW - Alosa aestivalis KW - Silver KW - Fundulus KW - J 02410:Animal Diseases KW - O 1070:Ecology/Community Studies KW - Q1 08484:Species interactions: parasites and diseases KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21262273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Fish+Diseases&rft.atitle=Mycobacteria+isolated+from+Chesapeake+Bay+fish&rft.au=Stine%2C+C+B%3BKane%2C+A+S%3BBaya%2C+A+M&rft.aulast=Stine&rft.aufirst=C&rft.date=2010-01-01&rft.volume=33&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Fish+Diseases&rft.issn=01407775&rft_id=info:doi/10.1111%2Fj.1365-2761.2009.01087.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2014-09-18 N1 - SubjectsTermNotLitGenreText - Marine fish; Fish diseases; Pelagic fisheries; Chromatographic techniques; Estuaries; Brackishwater environment; Diseases; Hosts; Freshwater fish; Rivers; Host specificity; Fidelity; fish diseases; Ulcers; Gas chromatography; Silver; Brevoortia tyrannus; Micropterus salmoides; Cynoscion nebulosus; Dorosoma cepedianum; Paralichthys dentatus; Ictalurus punctatus; Morone americana; Morone saxatilis; Cyprinus carpio; Bairdiella chrysoura; Cyprinus carpio carpio; Alosa aestivalis; Leiostomus xanthurus; Fundulus; INE, USA, Alaska, Alaska Gulf, Prince William Sound, Herring Bay; USA, Maryland, Potomac R.; USA, Maryland, Choptank R.; USA, Maryland, Pocomoke R.; ANW, USA, Chesapeake Bay; Freshwater; Brackish DO - http://dx.doi.org/10.1111/j.1365-2761.2009.01087.x ER - TY - JOUR T1 - A Health Hazard Evaluation of Antimony Exposure in Fire Fighters AN - 21261458; 11851628 AB - Objectives: Some firefighter station uniforms contain the flame-retardant, antimony trioxide. National Institute for Occupational Safety and Health investigated a possible outbreak of antimony toxicity wherein 30 firefighters reported elevated antimony levels on hair analyses. Methods: We surveyed and collected urine samples from firefighters not wearing (Fire Department A) and wearing (Fire Department B) antimony-containing pants. Urine antimony concentrations were measured and adjusted for creatinine. Results: All 20 participating firefighters from Fire Department A and 41 (97.6%) of 42 participating firefighters from Fire Department B had urine antimony concentrations below or within the national reference range. No differences in urine antimony levels between departments were detected. Conclusions: Wearing antimony-containing uniforms does not pose a risk for antimony toxicity. This investigation highlights the importance of using validated methods for toxicity determination and of accurate, timely risk communication. JF - Journal of Occupational and Environmental Medicine AU - de Perio, MA AU - Durgam, S AU - Caldwell, K L AU - Eisenberg, J AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Hazard Evaluations and Technical Assistance Branch, 4676 Columbia Pkwy, R-10, Cincinnati, OH 45226, USA, Mdeperio@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 81 EP - 84 VL - 52 IS - 1 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - firefighter services KW - Occupational safety KW - Communication KW - Fire retardant chemicals KW - Hazards KW - Fires KW - outbreaks KW - Toxicity KW - Hair KW - Communications KW - Creatinine KW - Urine KW - Antimony KW - Fire retardants KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21261458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=A+Health+Hazard+Evaluation+of+Antimony+Exposure+in+Fire+Fighters&rft.au=de+Perio%2C+MA%3BDurgam%2C+S%3BCaldwell%2C+K+L%3BEisenberg%2C+J&rft.aulast=de+Perio&rft.aufirst=MA&rft.date=2010-01-01&rft.volume=52&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181c7514a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Fires; Creatinine; Urine; Communication; Antimony; Fire retardant chemicals; Toxicity; Hair; Hazards; Communications; firefighter services; Occupational safety; outbreaks; Fire retardants DO - http://dx.doi.org/10.1097/JOM.0b013e3181c7514a ER - TY - JOUR T1 - Probes for narcotic receptor mediated phenomena. 40. N-Substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin -8-ols AN - 21235095; 11789857 AB - A series of N-substituted rac-cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c ]pyridin-8-ols have been prepared using a simple synthetic route previously designed for synthesis of related cis-2-methyl-4a-alkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c ]pyridin-6-ols. The new phenolic compounds, where the aromatic hydroxy moiety is situated ortho to the oxygen atom in the oxide-bridged ring, do not interact as well as the pyridin-6-ols with opioid receptors. The N-para-fluorophenethyl derivative had the highest k-opioid receptor affinity of the examined compounds (K sub(i) = 0.35 kM). JF - Bioorganic and Medicinal Chemistry AU - Iyer, Malliga R AU - Lee, Yong Sok AU - Deschamps, Jeffrey R AU - Rothman, Richard B AU - Dersch, Christina M AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Chemical Biology Research Branch, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 5625 Fishers Lane, Room 4N03, Bethesda, MD 20892-9415, USA, kr21f@nih.gov Y1 - 2010/01/01/ PY - 2010 DA - 2010 Jan 01 SP - 91 EP - 99 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 18 IS - 1 SN - 0968-0896, 0968-0896 KW - Biotechnology and Bioengineering Abstracts KW - Opioid receptors KW - Oxygen KW - Probes KW - phenolic compounds KW - Opioid receptors (type mu) KW - Aromatics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21235095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Probes+for+narcotic+receptor+mediated+phenomena.+40.+N-Substituted+cis-4a-ethyl-1%2C2%2C3%2C4%2C4a%2C9a-hexahydrobenzofuro%5B2%2C3-c%5Dpyridin+-8-ols&rft.au=Iyer%2C+Malliga+R%3BLee%2C+Yong+Sok%3BDeschamps%2C+Jeffrey+R%3BRothman%2C+Richard+B%3BDersch%2C+Christina+M%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Iyer&rft.aufirst=Malliga&rft.date=2010-01-01&rft.volume=18&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2009.11.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Opioid receptors; Oxygen; Probes; phenolic compounds; Opioid receptors (type mu); Aromatics DO - http://dx.doi.org/10.1016/j.bmc.2009.11.022 ER - TY - JOUR T1 - Two-dimensional biomechanical model for estimating strength of youth and adolescents for manual material handling tasks AN - 21161924; 11183885 AB - Youth and adolescents are routinely engaged in manual material handling (MMH) tasks that may exceed their strength capability to perform the task and may place them at excessive risk for musculoskeletal disorders. This paper reports on a two-dimensional biomechanical model that was developed to assess MMH tasks performed by youth 3-21 years of age. The model uses age, gender, posture of the youth performing the MMH activity, and weight of the load handled as input, and provides an estimate of the strength demands of the task and spinal disc compression and shear force resulting from the activity as output. The model can be used to assess whether a specific MMH task exceeds the strength demands for youth of certain ages or genders, which of the internal muscle strengths are most affected, and provides information about the estimated spinal disc compression and shear forces on the spine as a result of the specified MMH task. These results would be helpful in deciding whether a task is appropriate for a youth to perform or whether a certain task modification may be sufficient in reducing the physical demands to a level acceptable for a youth of certain age and gender. JF - Applied Ergonomics AU - Waters, Thomas R AU - Garg, Arun AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 4676 Columbia Parkway, 45226 Cincinnati, OH, USA, trw1@cdc.gov Y1 - 2010/01// PY - 2010 DA - Jan 2010 SP - 1 EP - 7 PB - Elsevier Science, The Boulevard Kidlington Oxford OX5 1GB UK VL - 41 IS - 1 SN - 0003-6870, 0003-6870 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Materials handling KW - Ergonomics KW - Adolescents KW - spine KW - biomechanics KW - musculoskeletal system KW - Gender KW - posture KW - R2 23080:Industrial and labor KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21161924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Ergonomics&rft.atitle=Two-dimensional+biomechanical+model+for+estimating+strength+of+youth+and+adolescents+for+manual+material+handling+tasks&rft.au=Waters%2C+Thomas+R%3BGarg%2C+Arun&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2010-01-01&rft.volume=41&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Applied+Ergonomics&rft.issn=00036870&rft_id=info:doi/10.1016%2Fj.apergo.2009.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Age; Gender; Adolescents; Materials handling; biomechanics; musculoskeletal system; Ergonomics; posture; spine DO - http://dx.doi.org/10.1016/j.apergo.2009.02.006 ER - TY - JOUR T1 - An analysis of flexural strength and crack width for fiber-reinforced shotcrete used in weak rock mines AN - 1800392361; 2016-056844 JF - Transactions of Society for Mining, Metallurgy, and Exploration AU - Martin, L AU - Seymour, B AU - Clark, C AU - Stepan, M AU - Pakalnis, R AU - Roworth, M AU - Caceres, C Y1 - 2010 PY - 2010 DA - 2010 SP - 542 EP - 549 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO VL - 328 SN - 1075-8623, 1075-8623 KW - United States KW - rock masses KW - mining KW - cut and fill KW - underground mining KW - strength KW - loading KW - flexure KW - weak rocks KW - reinforced materials KW - tensile strength KW - rock mechanics KW - planar bedding structures KW - shotcrete KW - safety KW - cracks KW - shear KW - compressive strength KW - sedimentary structures KW - Nevada KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800392361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.atitle=An+analysis+of+flexural+strength+and+crack+width+for+fiber-reinforced+shotcrete+used+in+weak+rock+mines&rft.au=Martin%2C+L%3BSeymour%2C+B%3BClark%2C+C%3BStepan%2C+M%3BPakalnis%2C+R%3BRoworth%2C+M%3BCaceres%2C+C&rft.aulast=Martin&rft.aufirst=L&rft.date=2010-01-01&rft.volume=328&rft.issue=&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Transactions+of+Society+for+Mining%2C+Metallurgy%2C+and+Exploration&rft.issn=10758623&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 18 N1 - PubXState - CO N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2016-06-30 N1 - SubjectsTermNotLitGenreText - compressive strength; cracks; cut and fill; flexure; loading; mining; Nevada; planar bedding structures; reinforced materials; rock masses; rock mechanics; safety; sedimentary structures; shear; shotcrete; strength; tensile strength; underground mining; United States; weak rocks ER - TY - JOUR T1 - Long-term follow-up of monoclonal B-cell lymphocytosis detected in environmental health studies? AN - 1468377790; 16714653 AB - Background: Four individuals in whom Monoclonal B cell Lymphocytosis (MBL) had been previously detected were evaluated for the fourth time after 15-18 years since initial testing. All four were environmental health study participants without hematologic malignancies who had elevated absolute B cell counts at initial testing. Methods: The current laboratory evaluation included complete blood counts, lymphocyte immunophenotypes, immunoglobulin heavy-chain variable (IGHV) gene mutation status, and serum tests for monoclonal immunoglobulins and free light chains. Results from this evaluation were compared with those from the three previous evaluations. Clinical status was assessed by reviewing medical records. Results: B-cell clones with phenotypic characteristics of the original MBL clone were detected in three of the four individuals. Since the last evaluation in 2003, one participant who had a clinical diagnosis of Waldenstrom's Macroglobulinemia had developed a diffuse large cell lymphoma and was treated. Another participant continued to show a decline in lymphocyte and B cell counts, reaching clinical lymphocytopenia and B cell lymphopenia. The MBL clone was still detectable. The remaining two participants had stable blood counts and MBL phenotypes. Neither had been diagnosed with a hematologic malignancy. However, molecular analysis revealed clonal changes in both: one showed a marked decline in the percentage of somatically-mutated B cells, and the other showed a clonal transition from IGHV3-13 to IGHV4-34. Conclusions: A diversity of clonal evolution was observed in these MBL cases. These observations suggest that long-term follow-up studies using standardized MBL subcategories are essential to understanding B-cell pathobiology and optimizing clinical management. Published 2010 Wiley-Liss, Inc. JF - Cytometry Part B AU - Marti, Gerald E AU - Shim, Youn K AU - Albitar, Maher AU - Middleton, Dan AU - Abbasi, Fatima AU - Anderson, Ayana AU - Vogt, Robert F AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, yshim@cdc.gov Y1 - 2010 PY - 2010 DA - 2010 SP - S83 EP - S90 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 78B IS - S1 SN - 1552-4957, 1552-4957 KW - Immunology Abstracts; Health & Safety Science Abstracts KW - Waldenstrom's macroglobulinemia KW - Light chains KW - medical records KW - Lymphocytes B KW - Point mutation KW - Lymphopenia KW - Environmental health KW - Lymphocytes KW - Cytometry KW - Blood KW - Malignancy KW - Lymphocytosis KW - Standards KW - lymphoma KW - Mutation KW - Lymphoma KW - Evolution KW - Immunoglobulins KW - F:0695 KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1468377790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+B&rft.atitle=Long-term+follow-up+of+monoclonal+B-cell+lymphocytosis+detected+in+environmental+health+studies%3F&rft.au=Marti%2C+Gerald+E%3BShim%2C+Youn+K%3BAlbitar%2C+Maher%3BMiddleton%2C+Dan%3BAbbasi%2C+Fatima%3BAnderson%2C+Ayana%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2010-01-01&rft.volume=78B&rft.issue=S1&rft.spage=S83&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+B&rft.issn=15524957&rft_id=info:doi/10.1002%2Fcyto.b.20522 L2 - http://onlinelibrary.wiley.com/doi/10.1002/cyto.b.20522/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-12-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Light chains; Waldenstrom's macroglobulinemia; Lymphocytes B; medical records; Point mutation; Lymphopenia; Cytometry; Blood; Malignancy; Lymphocytosis; Lymphoma; Evolution; Immunoglobulins; Environmental health; Standards; Lymphocytes; Mutation; lymphoma DO - http://dx.doi.org/10.1002/cyto.b.20522 ER - TY - RPRT T1 - Comprehensive Community Mental Health Services for Children and Their Families Program, Evaluation Findings: Annual Report to Congress 2010 AN - 1322245124; ED540209 AB - This report to Congress provides critical information about the Comprehensive Community Mental Health Services for Children and their Families Program (CMHI), including the characteristics of children, youth, and families as they enter the CMHI; the outcomes attained for children and youth, and their caregivers and families after entry into the CMHI; their CMHI service use and service experience; how well communities have implemented system of care principles, particularly interagency collaboration; the sustainability of systems of care; and caregiver and youth satisfaction with services. Data from the national evaluation demonstrate that funded systems of care: (1) Reach and provide services to many children and youth typically underserved by the mental health system; (2) Improve outcomes for children and youth; (3) Enhance family outcomes; (4) Expand the availability of effective supports and services; (5) Implement and maintain fidelity to the principles of family-driven, youth-guided, individualized services; (6) Save money by reducing the amount spent on residential treatment and juvenile justice services; and (7) Incorporate processes and resources that have a positive impact on sustainability. The national evaluation and this report to Congress have addressed the authorizing legislation's mandate to assess the effectiveness of the systems of care with regard to outcomes for children, youth, and families served by the CMHI. The report examined the use of hospitalization and other institutional settings, described the role and importance of interagency collaboration, and summarized parental assessments of the effectiveness of systems of care. Further, this report provided a description of how communities are carrying out the goal of the cooperative agreements by providing the types of services outlined in the legislation using an individualized, culturally and linguistically competent, and collaborative approach. Appended are: (1) Glossary of Terms; (2) SAMHSA's 8 Strategic Initiatives; (3) System of Care Communities of the Comprehensive Community Mental Health Services for Children and Their Families Program, 1993-2009; (4) Performance Measurement; (5) Description of Study Components; (6) Measures; (7) Data Analysis Techniques Used in This Report; and (8) Descriptive and Outcome Data Tables. (Contains 14 figures, 14 tables, and 27 endnotes.) Y1 - 2010 PY - 2010 DA - 2010 SP - 119 PB - SAMHSA's National Clearinghouse for Alcohol and Drug Information (NCADI). P.O. Box 2345, Rockville, MD 20847-2345. Tel: 800-729- 6686; Tel: 301-468-2600; Web site: http://ncadi.samhsa.gov KW - ERIC, Resources in Education (RIE) KW - Program Effectiveness KW - Depression (Psychology) KW - Anxiety KW - Individual Characteristics KW - Cooperation KW - Child Health KW - Suicide KW - Outcomes of Treatment KW - Emotional Disturbances KW - Caregivers KW - Symptoms (Individual Disorders) KW - Psychological Patterns KW - Program Implementation KW - Access to Health Care KW - Program Evaluation KW - Data Analysis KW - Financial Support KW - Community Programs KW - Residential Programs KW - Mental Health KW - Behavior Problems KW - Family Involvement KW - Health Services KW - Fidelity KW - Family Programs KW - Juvenile Justice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1322245124?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Recent trends in hormone therapy utilization and breast cancer incidence rates in the high incidence population of Marin County, California AN - 1285084687; 16863178 AB - Background: Recent declines in invasive breast cancer have been reported in the US, with many studies linking these declines to reductions in the use of combination estrogen/progestin hormone therapy (EPHT). We evaluated the changing use of postmenopausal hormone therapy, mammography screening rates, and the decline in breast cancer incidence specifically for Marin County, California, a population with historically elevated breast cancer incidence rates. Methods: The Marin Women's Study (MWS) is a community-based, prospective cohort study launched in 2006 to monitor changes in breast cancer, breast density, and personal and biologic risk factors among women living in Marin County. The MWS enrolled 1,833 women following routine screening mammography between October 2006 and July 2007. Participants completed a self-administered questionnaire that included items regarding historical hormone therapy regimen (estrogen only, progesterone only, EPHT), age of first and last use, total years of use, and reason(s) for stopping, as well as information regarding complementary hormone use. Questionnaire items were analyzed for 1,083 non-Hispanic white participants ages 50 and over. Breast cancer incidence rates were assessed overall and by tumor histology and estrogen receptor (ER) status for the years 1990-2007 using data from the Northern California Surveillance, Epidemiology and End Results (SEER) cancer registry. Results: Prevalence of EPHT use among non-Hispanic white women ages 50 and over declined sharply from 21.2% in 1998 to 6.7% by 2006-07. Estrogen only use declined from 26.9% in 1998 to 22.4% by 2006-07. Invasive breast cancer incidence rates declined 33.4% between 2001 and 2004, with drops most pronounced for ER+ cancers. These rate reductions corresponded to declines of about 50 cases per year, consistent with population attributable fraction estimates for EPHT-related breast cancer. Self-reported screening mammography rates did not change during this period. Use of alternative or complementary agents did not differ significantly between ever and never hormone users. Of women who reported stopping EPHT in the past 5 years, 60% cited "health risks" or "news reports" as their primary reasons for quitting. Conclusion: A dramatic reduction in EPHT use was followed temporally by a significant reduction in invasive and ER+ breast cancer rates among women living in Marin County, California. JF - BMC Public Health AU - Ereman, Rochelle R AU - Prebil, Lee Ann AU - Mockus, Mary AU - Koblick, Kathy AU - Orenstein, Fern AU - Benz, Christopher AU - Clarke, Christina A AD - County of Marin, Department of Health and Human Services, 20 North San Pedro Road, San Rafael, CA 94903, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 228 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 10 IS - 1 SN - 1471-2458, 1471-2458 KW - Health & Safety Science Abstracts KW - Age KW - Breast cancer KW - Cancer KW - Estrogens KW - Histology KW - Historical account KW - Hormones KW - Post-menopause KW - Risk factors KW - USA, California KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1285084687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Public+Health&rft.atitle=Recent+trends+in+hormone+therapy+utilization+and+breast+cancer+incidence+rates+in+the+high+incidence+population+of+Marin+County%2C+California&rft.au=Ereman%2C+Rochelle+R%3BPrebil%2C+Lee+Ann%3BMockus%2C+Mary%3BKoblick%2C+Kathy%3BOrenstein%2C+Fern%3BBenz%2C+Christopher%3BClarke%2C+Christina+A&rft.aulast=Ereman&rft.aufirst=Rochelle&rft.date=2010-01-01&rft.volume=10&rft.issue=1&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=BMC+Public+Health&rft.issn=14712458&rft_id=info:doi/10.1186%2F1471-2458-10-228 L2 - http://www.biomedcentral.com/1471-2458/10/228 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-02-01 N1 - Number of references - 27 N1 - Last updated - 2013-02-22 N1 - SubjectsTermNotLitGenreText - Historical account; Age; Estrogens; Histology; Post-menopause; Risk factors; Breast cancer; Hormones; Cancer; USA, California DO - http://dx.doi.org/10.1186/1471-2458-10-228 ER - TY - JOUR T1 - Fishery-Specific Risk Factors AN - 1171899454; 17342791 AB - Although progress has been made to improve safety on commercial fishing vessels, commercial fishing continaes to be the most dangerous occupation in the country. In 2008, commercial fishermen had a fatality rate nearly 36 times higher than the rate for all U.S. workers. super(1) Broad interventions on a national level have had some success in reducing fatalities, but greater improvements will come from tailored programs targeted at specific hazards of various fleets. JF - Marine Safety and Security Council. Proceedings: the Coast Guard journal of safety at sea AU - Lucas, D AU - Lincoln, J AD - National Institute for Occupational Safety and Health Alaska Pacific Regional Office, USA Y1 - 2010 PY - 2010 DA - 2010 SP - 18 EP - 20 PB - U.S. Coast Guard VL - 67 IS - 4 SN - 1547-9676, 1547-9676 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Marine KW - Mortality KW - Fishing vessels KW - Intervention KW - Councils KW - Risks KW - Hazards KW - Security KW - Commercial fishing KW - USA KW - Coastal zone KW - Risk factors KW - R2 23080:Industrial and labor KW - Q1 08341:General KW - Q5 08504:Effects on organisms KW - O 5020:Fisheries and Fishery Biology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1171899454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Safety+and+Security+Council.+Proceedings%3A+the+Coast+Guard+journal+of+safety+at+sea&rft.atitle=Fishery-Specific+Risk+Factors&rft.au=Lucas%2C+D%3BLincoln%2C+J&rft.aulast=Lucas&rft.aufirst=D&rft.date=2010-01-01&rft.volume=67&rft.issue=4&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Marine+Safety+and+Security+Council.+Proceedings%3A+the+Coast+Guard+journal+of+safety+at+sea&rft.issn=15479676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-11-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Hazards; Commercial fishing; Fishing vessels; Risks; Security; Mortality; Coastal zone; Risk factors; Intervention; Councils; USA; Marine ER - TY - GEN T1 - Child Care Helps America Work and Learn. Issue No. 1 AN - 1037910215; ED533822 AB - "Child Care Helps America Work and Learn" is a new publication produced by the Child Care Bureau. This new series will highlight some of the many Recovery Act-funded child care success stories from communities across the country that illustrate how the Bureau is working toward the shared goal of supporting children and families. This issue of "Child Care Helps America Work and Learn" contains the following articles: (1) Recovery Act Increases Enrollment and Quality Improvement in ACF Region IV; (2) Tennessee Serves Thousands of Children Through the Recovery Act; (3) Recovery Funding Supports Direct Services to Low-income Families; (4) Florida Uses Recovery Act Funds for Early Learning Initiatives; and (5) CCDF Highlights in Region IV: Recovery Act Investments Enhance Child Care Across the Southeast. Y1 - 2010/01// PY - 2010 DA - January 2010 SP - 2 PB - Child Care Bureau. US Department of Health and Human Services, Administration for Children & Families, Office of Family Assistance, 370 L'Enfant Promenade SW 5th Floor East, Washington, DC 20447. KW - Tennessee KW - Florida KW - United States (Southeast) KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Financial Support KW - Low Income Groups KW - Scholarship Funds KW - Federal Aid KW - Child Care KW - Educational Improvement KW - Enrollment Rate KW - Poverty Programs KW - Educational Opportunities KW - Investment KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1037910215?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2014-03-21 ER -