TY - JOUR T1 - Increasing the dose of television advertising in a national antismoking media campaign: results from a randomised field trial AN - 1859482102; PQ0003994435 AB - BackgroundWhile antismoking media campaigns have demonstrated effectiveness, less is known about the country-level effects of increased media dosing. The 2012 US Tips From Former Smokers (Tips) campaign generated approximately 1.6 million quit attempts overall; however, the specific dose-response from the campaign was only assessed by self-report.ObjectiveAssess the impact of higher ad exposure during the 2013 Tips campaign on quit-related behaviours and intentions, campaign awareness, communication about campaign, and disease knowledge.MethodsA 3-month national media buy was supplemented within 67 (of 190) randomly selected local media markets. Higher-dose markets received media buys 3 times that of standard-dose markets. We compared outcomes of interest using data collected via web-based surveys from nationally representative, address-based probability samples of 5733 cigarette smokers and 2843 non-smokers.ResultsIn higher-dose markets, 87.2% of smokers and 83.9% of non-smokers recalled television campaign exposure versus 75.0% of smokers and 73.9% of non-smokers in standard-dose markets. Among smokers overall, the relative quit attempt rate was 11% higher in higher-dose markets (38.8% vs 34.9%; p<0.04). The higher-dose increase was larger in African-Americans (50.9% vs 31.8%; p<0.01). Smokers in higher-dose markets without a mental health condition, with a chronic health condition, or with only some college education made quit attempts at a higher rate than those in standard-dose markets. Non-smokers in higher-dose markets were more likely to talk with family or friends about smoking dangers (43.1% vs 35.7%; p<0.01) and had greater knowledge of smoking-related diseases.ConclusionsThe US 2013 Tips antismoking media campaign compared standard and higher doses by randomisation of local media markets. Results demonstrate the effectiveness of a higher dose for engaging non-smokers and further increasing quit attempts among smokers, especially African-Americans. JF - Tobacco Control AU - McAfee, Tim AU - Davis, Kevin C AU - Shafer, Paul AU - Patel, Deesha AU - Alexander, Robert AU - Bunnell, Rebecca AD - Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, , Atlanta, Georgia, USA Y1 - 2017/01/17/ PY - 2017 DA - 2017 Jan 17 SP - 19 EP - 28 PB - BMJ Publishing Group Ltd. VL - 26 IS - 1 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Social marketing KW - Media KW - Cessation KW - Advertising and Promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859482102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Increasing+the+dose+of+television+advertising+in+a+national+antismoking+media+campaign%3A+results+from+a+randomised+field+trial&rft.au=McAfee%2C+Tim%3BDavis%2C+Kevin+C%3BShafer%2C+Paul%3BPatel%2C+Deesha%3BAlexander%2C+Robert%3BBunnell%2C+Rebecca&rft.aulast=McAfee&rft.aufirst=Tim&rft.date=2017-01-17&rft.volume=26&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2015-052517 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tobaccocontrol-2015-052517 ER - TY - JOUR T1 - Unhealthy environments, unhealthy consequences: Experienced homonegativity and HIV infection risk among young men who have sex with men AN - 1841839704 AB - Unfavourable social environments can negatively affect the health of gay, bisexual, and other men who have sex with men (MSM). We described how experienced homonegativity - negative perceptions and treatment that MSM encounter due to their sexual orientations - can increase HIV vulnerability among young MSM. Participants (n = 44) were young MSM diagnosed with HIV infection during January 2006-June 2009. All participants completed questionnaires that assessed experienced homonegativity and related factors (e.g. internalised homonegativity). We focus this analysis on qualitative interviews in which a subset of participants (n = 28) described factors that they perceived to have placed them at risk for HIV infection. Inductive content analysis identified themes within qualitative interviews, and we determined the prevalence of homonegativity and related factors using questionnaires. In qualitative interviews, participants reported that young MSM commonly experienced homonegativity. They described how homonegativity generated internalised homonegativity, HIV stigma, silence around homosexuality, and forced housing displacement. These factors could promote HIV risk. Homonegative experiences were more common among young Black (vs. non-Black) MSM who completed questionnaires. Results illustrate multiple pathways through which experienced homonegativity may increase HIV vulnerability among young MSM. Interventions that target homonegativity might help to reduce the burden of HIV within this population. JF - Global Public Health AU - Jeffries, William L, IV AU - Gelaude, Deborah J AU - Torrone, Elizabeth A AU - Gasiorowicz, Mari AU - Oster, Alexandra M AU - Spikes, Pilgrim S, Jr AU - McCree, Donna Hubbard AU - Bertolli, Jeanne AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA; Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA, USA; Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Division of Public Health, Wisconsin Department of Health Services, Madison, WI, USA ; Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA; Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 116 EP - 129 CY - Abingdon PB - Taylor & Francis Ltd. VL - 12 IS - 1 SN - 1744-1692 KW - Public Health And Safety KW - Homonegativity KW - men who have sex with men KW - HIV KW - Health risk assessment KW - Human immunodeficiency virus--HIV KW - Infections KW - Questionnaires KW - Mens health KW - Homosexuality KW - At risk KW - Bisexuals KW - Vulnerability KW - Housing KW - Stigmatization KW - Displacement KW - Infection KW - Men KW - Young men KW - Content analysis KW - Human Immunodeficiency Virus KW - Qualitative Methods KW - Stigma KW - Sex KW - Risk KW - Bisexuality KW - Males KW - Treatment KW - Content Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1841839704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Global+Public+Health&rft.atitle=Unhealthy+environments%2C+unhealthy+consequences%3A+Experienced+homonegativity+and+HIV+infection+risk+among+young+men+who+have+sex+with+men&rft.au=Jeffries%2C+William+L%2C+IV%3BGelaude%2C+Deborah+J%3BTorrone%2C+Elizabeth+A%3BGasiorowicz%2C+Mari%3BOster%2C+Alexandra+M%3BSpikes%2C+Pilgrim+S%2C+Jr%3BMcCree%2C+Donna+Hubbard%3BBertolli%2C+Jeanne&rft.aulast=Jeffries&rft.aufirst=William&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Global+Public+Health&rft.issn=17441692&rft_id=info:doi/10.1080%2F17441692.2015.1062120 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Copyright - This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1080/17441692.2015.1062120 ER - TY - JOUR T1 - Association of School District Policies for Radon Testing and Radon-Resistant New Construction Practices with Indoor Radon Zones. AN - 1852689424; 27983613 AB - Radon is a naturally occurring, colorless, odorless, and tasteless radioactive gas. Without testing, its presence is unknown. Using nationally representative data from the 2012 School Health Policies and Practices Study, we examined whether the prevalence of school district policies for radon testing and for radon-resistant new construction practices varied by district location in relation to the U.S. Environmental Protection Agency Map of Radon Zones. Among school districts located in counties with high predicted average indoor radon, 42.4% had policies for radon testing and 37.5% had policies for radon-resistant new construction practices. These findings suggest a critical need for improved awareness among policy makers regarding potential radon exposure for both students and school staff. JF - International journal of environmental research and public health AU - Foster, Stephanie AU - Everett Jones, Sherry AD - Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA. slfoster@cdc.gov. ; Centers for Disease Control and Prevention, Atlanta, GA 30329, USA. severettjones@cdc.gov. Y1 - 2016/12/13/ PY - 2016 DA - 2016 Dec 13 VL - 13 IS - 12 KW - schools KW - school district KW - testing KW - radon-resistant new construction KW - policy KW - radon UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852689424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Association+of+School+District+Policies+for+Radon+Testing+and+Radon-Resistant+New+Construction+Practices+with+Indoor+Radon+Zones.&rft.au=Foster%2C+Stephanie%3BEverett+Jones%2C+Sherry&rft.aulast=Foster&rft.aufirst=Stephanie&rft.date=2016-12-13&rft.volume=13&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+journal+of+environmental+research+and+public+health&rft.issn=1660-4601&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Secondhand smoke exposure at home among one billion children in 21 countries: findings from the Global Adult Tobacco Survey (GATS) AN - 1859490914; PQ0004003238 AB - ObjectiveChildren are vulnerable to secondhand smoke (SHS) exposure because of limited control over their indoor environment. Homes remain the major place where children may be exposed to SHS. Our study examines the magnitude, patterns and determinants of SHS exposure in the home among children in 21 countries (19 low-income and middle-income countries and 2 high-income countries).MethodsGlobal Adult Tobacco Survey (GATS) data, a household survey of people 15years of age or older. Data collected during 2009-2013 were analysed to estimate the proportion of children exposed to SHS in the home. GATS estimates and 2012 United Nations population projections for 2015 were also used to estimate the number of children exposed to SHS in the home.ResultsThe proportion of children younger than 15years of age exposed to SHS in the home ranged from 4.5% (Panama) to 79.0% (Indonesia). Of the approximately one billion children younger than 15years of age living in the 21 countries under study, an estimated 507.74 million were exposed to SHS in the home. China, India, Bangladesh, Indonesia and the Philippines accounted for almost 84.6% of the children exposed to SHS. The prevalence of SHS exposure was higher in countries with higher adult smoking rates and was also higher in rural areas than in urban areas, in most countries.ConclusionsA large number of children were exposed to SHS in the home. Encouraging of voluntary smoke-free rules in homes and cessation in adults has the potential to reduce SHS exposure among children and prevent SHS-related diseases and deaths. JF - Tobacco Control AU - Mbulo, Lazarous AU - Palipudi, Krishna Mohan AU - Andes, Linda AU - Morton, Jeremy AU - Bashir, Rizwan AU - Fouad, Heba AU - Ramanandraibe, Nivo AU - Caixeta, Roberta AU - Dias, Rula Cavaco AU - Wijnhoven, Trudy M A AU - Kashiwabara, Mina AU - Sinha, Dhirendra N AU - Tursan d'Espaignet, Edouard AD - Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Office of Smoking and Health, Global Tobacco Control Branch, , Atlanta, Georgia, USA Y1 - 2016/12/11/ PY - 2016 DA - 2016 Dec 11 SP - e95 EP - e100 PB - BMJ Publishing Group Ltd. VL - 25 IS - e2 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Secondhand smoke KW - Surveillance and monitoring KW - Global health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859490914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Secondhand+smoke+exposure+at+home+among+one+billion+children+in+21+countries%3A+findings+from+the+Global+Adult+Tobacco+Survey+%28GATS%29&rft.au=Mbulo%2C+Lazarous%3BPalipudi%2C+Krishna+Mohan%3BAndes%2C+Linda%3BMorton%2C+Jeremy%3BBashir%2C+Rizwan%3BFouad%2C+Heba%3BRamanandraibe%2C+Nivo%3BCaixeta%2C+Roberta%3BDias%2C+Rula+Cavaco%3BWijnhoven%2C+Trudy+M+A%3BKashiwabara%2C+Mina%3BSinha%2C+Dhirendra+N%3BTursan+d%27Espaignet%2C+Edouard&rft.aulast=Mbulo&rft.aufirst=Lazarous&rft.date=2016-12-11&rft.volume=25&rft.issue=e2&rft.spage=e95&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2015-052693 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1136/tobaccocontrol-2015-052693 ER - TY - JOUR T1 - Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems AN - 1850773866; PQ0003897366 AB - Lassa virus (LASV) and Ebola virus (EBOV) infections are important global health issues resulting in significant morbidity and mortality. While several promising drug and vaccine trials for EBOV are ongoing, options for LASV infection are currently limited to ribavirin treatment. A major factor impeding the development of antiviral compounds to treat these infections is the need to manipulate the virus under BSL-4 containment, limiting research to a few institutes worldwide. Here we describe the development of a novel LASV minigenome assay based on the ambisense LASV S segment genome, with authentic terminal untranslated regions flanking a ZsGreen (ZsG) fluorescent reporter protein and a Gaussia princeps luciferase (gLuc) reporter gene. This assay, along with a similar previously established EBOV minigenome, was optimized for high-throughput screening (HTS) of potential antiviral compounds under BSL-2 containment. In addition, we rescued a recombinant LASV expressing ZsG, which, in conjunction with a recombinant EBOV reporter virus, was used to confirm any potential antiviral hits in vitro. Combining an initial screen to identify potential antiviral compounds at BSL-2 containment before progressing to HTS with infectious virus will reduce the amount of expensive and technically challenging BSL-4 containment research. Using these assays, we identified 6-azauridine as having anti-LASV activity, and demonstrated its anti-EBOV activity in human cells. We further identified 2'-deoxy-2'-fluorocytidine as having potent anti-LASV activity, with an EC50 value 10 times lower than that of ribavirin. JF - Antiviral Research AU - Welch, Stephen R AU - Guerrero, Lisa Wiggleton AU - Chakrabarti, Ayan K AU - McMullan, Laura K AU - Flint, Mike AU - Bluemling, Gregory R AU - Painter, George R AU - Nichol, Stuart T AU - Spiropoulou, Christina F AU - Albarino, Cesar G AD - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MG G-14, Atlanta, GA, 30329, USA Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 9 EP - 18 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 136 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Mortality KW - Ebolavirus KW - Ribavirin KW - Infection KW - Morbidity KW - 6-Azauridine KW - Lassa virus KW - Antiviral agents KW - Reporter gene KW - Gaussia princeps KW - high-throughput screening KW - Vaccines KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850773866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Lassa+and+Ebola+virus+inhibitors+identified+using+minigenome+and+recombinant+virus+reporter+systems&rft.au=Welch%2C+Stephen+R%3BGuerrero%2C+Lisa+Wiggleton%3BChakrabarti%2C+Ayan+K%3BMcMullan%2C+Laura+K%3BFlint%2C+Mike%3BBluemling%2C+Gregory+R%3BPainter%2C+George+R%3BNichol%2C+Stuart+T%3BSpiropoulou%2C+Christina+F%3BAlbarino%2C+Cesar+G&rft.aulast=Welch&rft.aufirst=Stephen&rft.date=2016-12-01&rft.volume=136&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2016.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Genomes; Mortality; Antiviral agents; Reporter gene; Ribavirin; high-throughput screening; Vaccines; Infection; 6-Azauridine; Morbidity; Lassa virus; Gaussia princeps; Ebolavirus DO - http://dx.doi.org/10.1016/j.antiviral.2016.10.007 ER - TY - JOUR T1 - Perceived Bonding by Parents Living With HIV and Their Adolescent Children AN - 1847430861 AB - This study examined the associations between parent and adolescent reports of bonding within families and the relationships among reported parental bonding, family conflict and adolescent stress. A total of 118 families from Anhui, China, were recruited for this study. Two family-level bonding scores were constructed: the average of and difference between parent and adolescent bonding scores. Study results indicated that the difference between parent and adolescent bonding reports was associated with higher levels of adolescent daily stress. A negative association was observed between average family-level bonding and the level of parent-reported conflict. Our findings highlight the importance of combining data from both parents and adolescents when studying issues related to family wellbeing. JF - Journal of Research on Adolescence AU - Li, Li AU - Liang, Li-Jung AU - Ji, Guoping AU - Lin, Chunqing AU - Xiao, Yongkang AD - University of California, Los Angeles ; Anhui Provincial Center for Disease Control and Prevention ; University of California, Los Angeles Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 880 EP - 888 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 26 IS - 4 SN - 1050-8392 KW - Psychology KW - Acquired Immune Deficiency Syndrome KW - Parents KW - Family Conflict KW - Family KW - Parent Child Relations KW - Children KW - Adolescents KW - Well Being KW - Stress KW - Parental bonding KW - HIV KW - Family conflict KW - Wellbeing KW - Daily stress KW - 1939:the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1847430861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Research+on+Adolescence&rft.atitle=Perceived+Bonding+by+Parents+Living+With+HIV+and+Their+Adolescent+Children&rft.au=Li%2C+Li%3BLiang%2C+Li-Jung%3BJi%2C+Guoping%3BLin%2C+Chunqing%3BXiao%2C+Yongkang&rft.aulast=Li&rft.aufirst=Li&rft.date=2016-12-01&rft.volume=26&rft.issue=4&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Journal+of+Research+on+Adolescence&rft.issn=10508392&rft_id=info:doi/10.1111%2Fjora.12236 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Sociological Abstracts N1 - Copyright - Journal of Research on Adolescence © 2016 Society for Research on Adolescence N1 - Last updated - 2017-01-17 DO - http://dx.doi.org/10.1111/jora.12236 ER - TY - JOUR T1 - Estimates of CDC-Funded and National HIV Diagnoses: A Comparison by Demographic and HIV-related Factors AN - 1846414857; PQ0003886096 AB - To determine whether CDC-funded HIV testing programs are reaching persons disproportionately affected by HIV infection. The percentage distribution for HIV testing and diagnoses by demographics and transmission risk group (diagnoses only) were calculated using 2013 data from CDC's National HIV Surveillance System and CDC's national HIV testing program data. In 2013, nearly 3.2 million CDC-funded tests were provided to persons aged 13 years and older. Among persons who received a CDC-funded test, 41.1 % were aged 20-29 years; 49.2 % were male, 46.2 % were black/African American, and 56.2 % of the tests were conducted in the South. Compared with the characteristics of all persons diagnosed with HIV in the United States in 2013, among persons diagnosed as a result of CDC-funded tests, a higher percentage were aged 20-29 years (40.3 vs 33.7 %) and black/African American (55.3 vs 46.0 %). CDC-funded HIV testing programs are reaching young people and blacks/African Americans. JF - AIDS and Behavior AU - Krueger, Amy AU - Dietz, Patricia AU - Van Handel, Michelle AU - Belcher, Lisa AU - Johnson, Anna Satcher AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC, 1600 Clifton Road, NE, Mailstop E-59, Atlanta, GA, 30333, USA, akrueger@cdc.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2961 EP - 2965 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 20 IS - 12 SN - 1090-7165, 1090-7165 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Demography KW - USA KW - Acquired immune deficiency syndrome KW - Lentivirus KW - Risk factors KW - Retroviridae KW - Infection KW - Ethnic groups KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846414857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Estimates+of+CDC-Funded+and+National+HIV+Diagnoses%3A+A+Comparison+by+Demographic+and+HIV-related+Factors&rft.au=Krueger%2C+Amy%3BDietz%2C+Patricia%3BVan+Handel%2C+Michelle%3BBelcher%2C+Lisa%3BJohnson%2C+Anna+Satcher&rft.aulast=Krueger&rft.aufirst=Amy&rft.date=2016-12-01&rft.volume=20&rft.issue=12&rft.spage=2961&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-016-1293-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Demography; Acquired immune deficiency syndrome; Risk factors; Infection; Ethnic groups; Lentivirus; Retroviridae; USA DO - http://dx.doi.org/10.1007/s10461-016-1293-1 ER - TY - JOUR T1 - Racial/ethnic disparities in self-reported short sleep duration among US-born and foreign-born adults AN - 1818393452 AB - Objective. Racial/ethnic health disparities are infrequently considered by nativity status in the United States, although the immigrant population has practically doubled since 1990. We investigated the modifying role of nativity status (US- vs. foreign-born) on racial/ethnic disparities in short sleep duration (<7 h), which has serious health consequences. Design. Cross-sectional data from 23,505 US-born and 4,326 foreign-born adults aged [greater than or equal to] 18 years from the 2012 National Health Interview Survey and multivariable log-linear regression were used to estimate prevalence ratios (PR) for reporting short sleep duration and their corresponding 95% confidence intervals (CI). Results. After controlling for sociodemographic covariates, short sleep was more prevalent among blacks (PR 1.29, 95% CI: 1.21-1.37), Hispanics (PR 1.18, 95% CI: 1.08, 1.29), and Asians (PR 1.37, 95% CI: 1.16-1.61) than whites among US-born adults. Short sleep was more prevalent among blacks (PR 1.71, 95% CI: 1.38, 2.13) and Asians (PR 1.23, 95% CI: 1.02, 1.47) than whites among the foreign-born. Conclusion. Among both US- and foreign-born adults, blacks and Asians had a higher likelihood of short sleep compared to whites. US-born Hispanics, but not foreign-born Hispanics, had a higher likelihood than their white counterparts. Future research should aim to uncover mechanisms underlying these disparities. JF - Ethnicity and Health AU - Cunningham, Timothy J AU - Wheaton, Anne G AU - Ford, Earl S AU - Croft, Janet B AD - Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 628 EP - 638 CY - Abingdon PB - Taylor & Francis Ltd. VL - 21 IS - 6 SN - 1355-7858 KW - Public Health And Safety KW - Sleep KW - nativity KW - immigration KW - race KW - ethnicity KW - stress KW - Health Problems KW - Methodology (Data Collection) KW - Ethnicity KW - Racial Differences KW - Elderly KW - Sociodemographic Factors KW - United States--US KW - 2045:sociology of health and medicine; sociology of medicine & health care KW - 6140:illness & health care KW - 6148:problems of minority groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1818393452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+and+Health&rft.atitle=Racial%2Fethnic+disparities+in+self-reported+short+sleep+duration+among+US-born+and+foreign-born+adults&rft.au=Cunningham%2C+Timothy+J%3BWheaton%2C+Anne+G%3BFord%2C+Earl+S%3BCroft%2C+Janet+B&rft.aulast=Cunningham&rft.aufirst=Timothy&rft.date=2016-12-01&rft.volume=21&rft.issue=6&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Ethnicity+and+Health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557858.2016.1179724 LA - English DB - Social Services Abstracts; Sociological Abstracts N1 - Copyright - This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. N1 - Last updated - 2016-11-21 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1080/13557858.2016.1179724 ER - TY - JOUR T1 - Efficacy of Chloroquine and Primaquine for the Treatment of Uncomplicated Plasmodium vivax Malaria in Cruzeiro do Sul, Brazil AN - 1850778645; PQ0003910115 AB - We evaluated the efficacy of chloroquine and primaquine on uncomplicated Plasmodium vivax malaria in Cruzeiro do Sul, Brazil, in 2014. Patients > or = 5 years of age with either fever or history of fever, and laboratory-confirmed P. vivax monoinfection received chloroquine (total dose = 25 mg/kg) and primaquine (total dose = 3.5 mg/kg), and were followed up for 168 days (24 weeks). We used microsatellite genotyping to differentiate recurrent infections caused by heterologous parasites from those caused by homologous ones. No new P. vivax episode occurred by Day 28 among 119 enrolled patients, leading to Day 28, with adequate clinical and parasitological response (ACPR) of 100% (95% confidence interval [CI] = 96.7-100%). Twenty-eight P. vivax episodes occurred by Day 168, with uncorrected ACPR of 69.9% (95% CI = 59.5-79.0%). Fifteen of these episodes were caused by either homologous haplotypes or haplotypes that could not be determined. Excluding the 13 recurrent episodes caused by heterologous parasites, Day 168 microsatellite-corrected ACPR was estimated at 81.2% (95% CI = 71.0-89.1%). Chloroquine and primaquine remain efficacious to treat acute uncomplicated P. vivax infection, but moderate recurrence rates were observed within 24 weeks of follow-up. JF - American Journal of Tropical Medicine and Hygiene AU - Negreiros, Suiane AU - Farias, Samela AU - Viana, Giselle Maria Rachid AU - Okoth, Sheila Akinyi AU - Chenet, Stella M AU - de Souza, Thayna Maria Holanda AU - Marchesini, Paola AU - Udhayakumar, Venkatachalam AU - Povoa, Marinete Marins AU - Santelli, Ana Carolina Faria e Silva AU - de Oliveira, Alexandre Macedo AD - Acre State Health Secretariat, Acre State, Brazil, acq7@cdc.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1061 EP - 1068 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 5 SN - 0002-9637, 0002-9637 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Historical account KW - Parasites KW - Human diseases KW - Nucleotide sequence KW - Disease control KW - Plasmodium vivax KW - Malaria KW - Genotypes KW - Infection KW - Public health KW - Haplotypes KW - DNA KW - Hygiene KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850778645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Efficacy+of+Chloroquine+and+Primaquine+for+the+Treatment+of+Uncomplicated+Plasmodium+vivax+Malaria+in+Cruzeiro+do+Sul%2C+Brazil&rft.au=Negreiros%2C+Suiane%3BFarias%2C+Samela%3BViana%2C+Giselle+Maria+Rachid%3BOkoth%2C+Sheila+Akinyi%3BChenet%2C+Stella+M%3Bde+Souza%2C+Thayna+Maria+Holanda%3BMarchesini%2C+Paola%3BUdhayakumar%2C+Venkatachalam%3BPovoa%2C+Marinete+Marins%3BSantelli%2C+Ana+Carolina+Faria+e+Silva%3Bde+Oliveira%2C+Alexandre+Macedo&rft.aulast=Negreiros&rft.aufirst=Suiane&rft.date=2016-11-01&rft.volume=95&rft.issue=5&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Nucleotide sequence; DNA; Disease control; Malaria; Genotypes; Hygiene; Public health; Historical account; Haplotypes; Infection; Plasmodium vivax DO - http://dx.doi.org/10.4269/ajtmh.16-0075 ER - TY - JOUR T1 - An Outbreak of Fearsome Photos and Headlines: Ebola and Local Newspapers in West Africa AN - 1850777588; PQ0003910100 AB - "Let me get this right, the pilot wants to talk with me in the cockpit?" I asked the flight attendant, as the final passengers boarded the Liberia-bound jet during a refueling stop in west Africa. It was late March 2014, and a small Ebola virus disease (EVD) outbreak had been reported a few weeks earlier in Guinea. The half-read pile of malaria journal articles on my lap provided the flight crew sufficient evidence to conclude there was a "tropical medicine guy" on the flight, just what they needed for their current dilemma. As I walked toward the front of the plane, I had a suspicion what the upcoming topic of discussion would be. JF - American Journal of Tropical Medicine and Hygiene AU - Halsey, Eric S AD - The President's Malaria Initiative, Atlanta, Georgia, ycw8@cdc.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 988 EP - 992 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 5 SN - 0002-9637, 0002-9637 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Human diseases KW - Ebolavirus KW - Viruses KW - Pilots KW - Malaria KW - Public health KW - Lectures KW - Guinea KW - Photographs KW - Africa KW - Outbreaks KW - Hygiene KW - Q1 08423:Behaviour KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850777588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=An+Outbreak+of+Fearsome+Photos+and+Headlines%3A+Ebola+and+Local+Newspapers+in+West+Africa&rft.au=Halsey%2C+Eric+S&rft.aulast=Halsey&rft.aufirst=Eric&rft.date=2016-11-01&rft.volume=95&rft.issue=5&rft.spage=988&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Lectures; Human diseases; Photographs; Malaria; Hygiene; Public health; Pilots; Viruses; Outbreaks; Ebolavirus; Guinea; Africa DO - http://dx.doi.org/10.4269/ajtmh.16-0245 ER - TY - JOUR T1 - Partnerships that Facilitate a Refugee's Journey to Wellbeing AN - 1850774525; PQ0003910099 AB - The current global refugee crisis involves 65.3 million persons who have been displaced from their homes or countries of origin. While escaping immediate harm may be their first priority, displaced people go on to face numerous health risks, including trauma and injuries, malnutrition, infectious diseases, exacerbation of existing chronic diseases, and mental health conditions. This crisis highlights the importance of building capacity among health-care providers, scientists, and laboratorians to understand and respond to the health needs of refugees. The November 2016 American Society of Tropical Medicine and Hygiene (ASTMH) conference in Atlanta will feature an interactive exhibit entitled "The Refugee Journey to Wellbeing" and three symposia about refugee health. The symposia will focus on tropical disease challenges in refugee populations, careers in refugee health, and recent experiences of governmental agencies and nongovernmental organizations in responding to the global refugee crisis. We invite ASTMH attendees to attend the exhibit and symposia and consider contributions they could make to improve refugee health through tropical disease research or clinical endeavors. JF - American Journal of Tropical Medicine and Hygiene AU - Marano, Nina AU - Wojno, Abbey E AU - Stauffer, William M AU - Weinberg, Michelle AU - Klosovsky, Alexander AU - Ballew, J Daniel AU - Shetty, Sharmila AU - Cookson, Susan AU - Walker, Patricia AU - Cetron, Martin S AD - Centers for Disease Control and Prevention, Atlanta, Georgia, nbm8@cdc.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 985 EP - 987 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 5 SN - 0002-9637, 0002-9637 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Conferences KW - Injuries KW - Crises KW - Careers KW - Buildings KW - Refugees KW - Disease transmission KW - Health risks KW - Mental disorders KW - Malnutrition KW - Infectious diseases KW - Priorities KW - USA, Georgia, Atlanta KW - Governments KW - Hygiene KW - Nongovernmental organizations KW - H 11000:Diseases/Injuries/Trauma KW - Q1 08104:Personal KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850774525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Partnerships+that+Facilitate+a+Refugee%27s+Journey+to+Wellbeing&rft.au=Marano%2C+Nina%3BWojno%2C+Abbey+E%3BStauffer%2C+William+M%3BWeinberg%2C+Michelle%3BKlosovsky%2C+Alexander%3BBallew%2C+J+Daniel%3BShetty%2C+Sharmila%3BCookson%2C+Susan%3BWalker%2C+Patricia%3BCetron%2C+Martin+S&rft.aulast=Marano&rft.aufirst=Nina&rft.date=2016-11-01&rft.volume=95&rft.issue=5&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Injuries; Infectious diseases; Careers; Governments; Hygiene; Disease transmission; Conferences; Crises; Refugees; Buildings; Health risks; Mental disorders; Malnutrition; Priorities; Nongovernmental organizations; USA, Georgia, Atlanta DO - http://dx.doi.org/10.4269/ajtmh.16-0657 ER - TY - JOUR T1 - A chronological review of experimental infection studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus AN - 1846417609; PQ0003845341 AB - This article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus (CCHFV), the etiologic agent of Crimean-Congo hemorrhagic fever (CCHF), beginning with the first recognized outbreak of the human disease in Crimea in 1944. Published reports by researchers in the former Soviet Union, Bulgaria, South Africa, and other countries where CCHF has been observed show that CCHFV is maintained in nature in a tick-vertebrate-tick enzootic cycle. Human disease most commonly results from the bite of an infected tick, but may also follow crushing of infected ticks or exposure to the blood and tissues of infected animals during slaughter. Wild and domestic animals are susceptible to infection with CCHFV, but do not develop clinical illness. Vertebrates are important in CCHF epidemiology, as they provide blood meals to support tick populations, transport ticks across wide geographic areas, and transmit CCHFV to ticks and humans during the period of viremia. Many aspects of vertebrate involvement in the maintenance and spread of CCHFV are still poorly understood. Experimental investigations in wild animals and livestock provide important data to aid our understanding of CCHFV ecology. This article is the second in a series of reviews of more than 70 years of research on CCHF, summarizing important findings, identifying gaps in knowledge, and suggesting directions for future research. JF - Antiviral Research AU - Spengler, Jessica R AU - Estrada-Pena, Agustin AU - Garrison, Aura R AU - Schmaljohn, Connie AU - Spiropoulou, Christina F AU - Bergeron, Eric AU - Bente, Dennis A AD - Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 31 EP - 47 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 135 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Crimean-Congo hemorrhagic fever KW - Bunyavirus KW - Tick-borne KW - Viral hemorrhagic fever KW - Transmission KW - Experimental infection KW - Data processing KW - Bites KW - Ixodidae KW - Blood meals KW - Bunyaviridae KW - Disease transmission KW - Livestock KW - Domestic animals KW - Blood KW - Epidemiology KW - Reviews KW - Hemorrhagic fever KW - Slaughter KW - Viremia KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846417609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=A+chronological+review+of+experimental+infection+studies+of+the+role+of+wild+animals+and+livestock+in+the+maintenance+and+transmission+of+Crimean-Congo+hemorrhagic+fever+virus&rft.au=Spengler%2C+Jessica+R%3BEstrada-Pena%2C+Agustin%3BGarrison%2C+Aura+R%3BSchmaljohn%2C+Connie%3BSpiropoulou%2C+Christina+F%3BBergeron%2C+Eric%3BBente%2C+Dennis+A&rft.aulast=Spengler&rft.aufirst=Jessica&rft.date=2016-11-01&rft.volume=135&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2016.09.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Experimental infection; Data processing; Bites; Blood meals; Livestock; Disease transmission; Blood; Domestic animals; Epidemiology; Reviews; Hemorrhagic fever; Slaughter; Viremia; Ixodidae; Bunyaviridae DO - http://dx.doi.org/10.1016/j.antiviral.2016.09.013 ER - TY - JOUR T1 - Prescription of Pneumocystis Jiroveci Pneumonia Prophylaxis in HIV-Infected Patients AN - 1846415290; PQ0003843920 AB - The US treatment guidelines recommend Pneumocystis jiroveci pneumonia (PCP) prophylaxis for all HIV-infected persons with a CD4 count <200 cells/mm 3 (ie, eligible for PCP prophylaxis). However, some studies suggest PCP prophylaxis may be unnecessary in virally suppressed patients. Using national data of HIV-infected adults receiving medical care in the United States during 2009 to 2012, the authors assessed the weighted percentage of eligible patients who were prescribed PCP prophylaxis and the independent association between PCP prophylaxis prescription and viral suppression. Overall, 81% of eligible patients were prescribed PCP prophylaxis. Virally suppressed eligible patients were less likely to be prescribed PCP prophylaxis (prevalence ratio: 0.84; 95% confidence interval: 0.80-0.89). Although guidelines recommend PCP prophylaxis for all eligible patients, some HIV care providers might not prescribe PCP prophylaxis to virally suppressed patients. Additional data on the risk for PCP among virally suppressed patients are needed to clarify this controversy. JF - Journal of the International Association of Providers of AIDS Care (JIAPAC) AU - Lin, Xia AU - Garg, Shikha AU - Mattson, Christine L AU - Luo, Qingwei AU - Skarbinski, Jacek AD - 1 .Epidemic Intelligence Service, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA, wft4@cdc.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 455 EP - 458 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 15 IS - 6 SN - 2325-9574, 2325-9574 KW - Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts KW - HIV KW - Pneumocystis pneumonia prophylaxis KW - viral suppression KW - Risk assessment KW - USA KW - Acquired immune deficiency syndrome KW - Lentivirus KW - Retroviridae KW - Guidelines KW - Pneumocystis KW - Prophylaxis KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846415290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.atitle=Prescription+of+Pneumocystis+Jiroveci+Pneumonia+Prophylaxis+in+HIV-Infected+Patients&rft.au=Lin%2C+Xia%3BGarg%2C+Shikha%3BMattson%2C+Christine+L%3BLuo%2C+Qingwei%3BSkarbinski%2C+Jacek&rft.aulast=Lin&rft.aufirst=Xia&rft.date=2016-11-01&rft.volume=15&rft.issue=6&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.issn=23259574&rft_id=info:doi/10.1177%2F2325957416667486 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 14 N1 - Last updated - 2017-02-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Acquired immune deficiency syndrome; Guidelines; Prophylaxis; Lentivirus; Retroviridae; Pneumocystis; USA DO - http://dx.doi.org/10.1177/2325957416667486 ER - TY - JOUR T1 - Plasmodium falciparum Drug-Resistant Haplotypes and Population Structure in Postearthquake Haiti, 2010 AN - 1850769128; PQ0003935475 AB - Chloroquine (CQ) remains the first-line treatment of malaria in Haiti. Given the challenges of conducting in vivo drug efficacy trials in low-endemic settings like Haiti, molecular surveillance for drug resistance markers is a reasonable approach for detecting resistant parasites. In this study, 349 blood spots were collected from suspected malaria cases in areas in and around Port-au-Prince from March to July 2010. Among them, 121 samples that were Plasmodium falciparum positive by polymerase chain reaction were genotyped for drug-resistant pfcrt, pfdhfr, pfdhps, and pfmdr1 alleles. Among the 108 samples that were successfully sequenced for CQ resistant markers in pfcrt, 107 were wild type (CVMNK), whereas one sample carried a CQ-resistant allele (CVIET). Neutral microsatellite genotyping revealed that the CQ-resistant isolate was distinct from all other samples in this study. Furthermore, the remaining parasite specimens appeared to be genetically distinct from other reported Central and South American populations. JF - American Journal of Tropical Medicine and Hygiene AU - Morton, Lindsay Carol AU - Huber, Curtis AU - Okoth, Sheila Akinyi AU - Griffing, Sean AU - Lucchi, Naomi AU - Ljolje, Dragan AU - Boncy, Jacques AU - Oscar, Roland AU - Townes, David AU - McMorrow, Meredith AU - Chang, Michelle A AU - Udhayakumar, Venkatachalam AU - Barnwell, John W AD - Centers for Disease Control and Prevention, Atlanta, Georgia, wzb3@cdc.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 811 EP - 816 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 4 SN - 0002-9637, 0002-9637 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Allelles KW - Drug resistance KW - Nucleotide sequence KW - Malaria KW - Plasmodium falciparum KW - Parasite resistance KW - Public health KW - Population genetics KW - Blood KW - Haplotypes KW - Population structure KW - Hygiene KW - Drugs KW - ASW, Caribbean Sea, Greater Antilles, Haiti KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850769128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Plasmodium+falciparum+Drug-Resistant+Haplotypes+and+Population+Structure+in+Postearthquake+Haiti%2C+2010&rft.au=Morton%2C+Lindsay+Carol%3BHuber%2C+Curtis%3BOkoth%2C+Sheila+Akinyi%3BGriffing%2C+Sean%3BLucchi%2C+Naomi%3BLjolje%2C+Dragan%3BBoncy%2C+Jacques%3BOscar%2C+Roland%3BTownes%2C+David%3BMcMorrow%2C+Meredith%3BChang%2C+Michelle+A%3BUdhayakumar%2C+Venkatachalam%3BBarnwell%2C+John+W&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2016-10-01&rft.volume=95&rft.issue=4&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0214 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Blood; Population genetics; Parasites; Human diseases; Allelles; Nucleotide sequence; Malaria; Hygiene; Public health; Haplotypes; Drug resistance; Population structure; Parasite resistance; Drugs; Plasmodium falciparum; ASW, Caribbean Sea, Greater Antilles, Haiti DO - http://dx.doi.org/10.4269/ajtmh.16-0214 ER - TY - JOUR T1 - Factors predicting double embryo implantation following double embryo transfer in assisted reproductive technology: implications for elective single embryo transfer AN - 1837334443; PQ0003771367 AB - The aim of this study was to identify factors associated with double embryo implantation following double embryo transfer (DET) during assisted reproductive technology (ART) procedures and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). Factors predicting double embryo implantation, defined as embryo transfers with two or more heartbeats on 6-week ultrasound following DET, were assessed using the US National ART Surveillance System data from 2000 to 2012 (n=1,793,067 fresh, autologous transfers). Adjusted risk ratios (aRRs) were estimated after stratifying by prognosis. Favorable prognosis was defined as first-time ART with supernumerary embryo(s) cryopreserved. Average prognosis was defined as first-time ART without supernumerary embryo(s) cryopreserved, prior unsuccessful ART with supernumerary embryo(s) cryopreserved, or prior ART with previous birth(s) conceived with ART or naturally. Rates and factors associated with double embryo implantation were compared with single embryo implantation following DET among both prognosis groups. Double embryo implantation was positively associated with blastocyst (versus cleavage) transfer in favorable (aRR=1.58 (1.51-1.65)) and average (aRR=1.67 (1.60-1.75)) prognosis groups and negatively associated with age >35 years in both prognosis groups. For average prognosis patients, double embryo implantation was associated with retrieving >10 oocytes (aRR=1.22 (1.18-1.24)). Regardless of prognosis, patients aged 10 oocytes were retrieved may be good candidates for eSET. Physicians may consider using these data to counsel patients on eSET, which would reduce multiple gestations and associated complications. JF - Journal of Assisted Reproduction and Genetics AU - Martin, Caitlin AU - Chang, Jeani AU - Boulet, Sheree AU - Jamieson, Denise J AU - Kissin, Dmitry AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F-74, Atlanta, GA, 30341, USA, Caitlin.Martin@emory.edu Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1343 EP - 1353 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 33 IS - 10 SN - 1058-0468, 1058-0468 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Heart KW - Age KW - Data processing KW - Prognosis KW - Cryopreservation KW - blastocysts KW - Gestation KW - Oocytes KW - Embryo transfer KW - Reproduction KW - Ultrasound KW - Supernumerary KW - W 30910:Imaging KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837334443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Assisted+Reproduction+and+Genetics&rft.atitle=Factors+predicting+double+embryo+implantation+following+double+embryo+transfer+in+assisted+reproductive+technology%3A+implications+for+elective+single+embryo+transfer&rft.au=Martin%2C+Caitlin%3BChang%2C+Jeani%3BBoulet%2C+Sheree%3BJamieson%2C+Denise+J%3BKissin%2C+Dmitry&rft.aulast=Martin&rft.aufirst=Caitlin&rft.date=2016-10-01&rft.volume=33&rft.issue=10&rft.spage=1343&rft.isbn=&rft.btitle=&rft.title=Journal+of+Assisted+Reproduction+and+Genetics&rft.issn=10580468&rft_id=info:doi/10.1007%2Fs10815-016-0770-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 34 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Age; blastocysts; Data processing; Gestation; Prognosis; Oocytes; Reproduction; Embryo transfer; Ultrasound; Cryopreservation; Supernumerary DO - http://dx.doi.org/10.1007/s10815-016-0770-9 ER - TY - JOUR T1 - Enhanced Genetic Characterization of Influenza A(H3N2) Viruses and Vaccine Effectiveness by Genetic Group, 2014-2015 AN - 1827913141; PQ0003697923 AB - Background. During the 2014-2015 US influenza season, expanded genetic characterization of circulating influenza A(H3N2) viruses was used to assess the impact of the genetic variability of influenza A(H3N2) viruses on influenza vaccine effectiveness (VE). Methods. A novel pyrosequencing assay was used to determine genetic group, based on hemagglutinin (HA) gene sequences, of influenza A(H3N2) viruses from patients enrolled at US Influenza Vaccine Effectiveness Network sites. VE was estimated using a test-negative design comparing vaccination among patients infected with influenza A(H3N2) viruses and uninfected patients. Results. Among 9710 enrollees, 1868 (19%) tested positive for influenza A(H3N2) virus; genetic characterization of 1397 viruses showed that 1134 (81%) belonged to 1 HA genetic group (3C.2a) of antigenically drifted influenza A(H3N2) viruses. Effectiveness of 2014-2015 influenza vaccination varied by influenza A(H3N2) virus genetic group from 1% (95% confidence interval [CI], ?14% to 14%) against illness caused by antigenically drifted influenza A(H3N2) virus group 3C.2a viruses versus 44% (95% CI, 16%-63%) against illness caused by vaccine-like influenza A(H3N2) virus group 3C.3b viruses. Conclusions. Effectiveness of 2014-2015 influenza vaccination varied by genetic group of influenza A(H3N2) virus. Changes in HA genes related to antigenic drift were associated with reduced VE JF - Journal of Infectious Diseases AU - Flannery, Brendan AU - Zimmerman, Richard K AU - Gubareva, Larisa V AU - Garten, Rebecca J AU - Chung, Jessie R AU - Nowalk, Mary Patricia AU - Jackson, Michael L AU - Jackson, Lisa A AU - Monto, Arnold S AU - Ohmit, Suzanne E AD - Influenza Division, Centers for Disease Control and Prevention, bflannery@cdc.gov Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 1010 EP - 1019 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 7 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - influenza KW - genetic characterization KW - pyrosequencing KW - influenza vaccine KW - vaccine effectiveness KW - Influenza KW - Antigenic drift KW - Infectious diseases KW - Hemagglutinins KW - Viruses KW - Vaccines KW - Vaccination KW - V 22310:Genetics, Taxonomy & Structure KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827913141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Enhanced+Genetic+Characterization+of+Influenza+A%28H3N2%29+Viruses+and+Vaccine+Effectiveness+by+Genetic+Group%2C+2014-2015&rft.au=Flannery%2C+Brendan%3BZimmerman%2C+Richard+K%3BGubareva%2C+Larisa+V%3BGarten%2C+Rebecca+J%3BChung%2C+Jessie+R%3BNowalk%2C+Mary+Patricia%3BJackson%2C+Michael+L%3BJackson%2C+Lisa+A%3BMonto%2C+Arnold+S%3BOhmit%2C+Suzanne+E&rft.aulast=Flannery&rft.aufirst=Brendan&rft.date=2016-10-01&rft.volume=214&rft.issue=7&rft.spage=1010&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw181 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Influenza; Antigenic drift; Hemagglutinins; Vaccines; Vaccination; Infectious diseases; Viruses DO - http://dx.doi.org/10.1093/infdis/jiw181 ER - TY - JOUR T1 - Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection AN - 1827913026; PQ0003697928 AB - Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that efficiently delivers tenofovir diphosphate to lymphoid cells following oral administration. We investigated whether the combination of TAF and emtricitabine (FTC) could prevent simian/human immunodeficiency virus (SHIV) infection in macaques to determine the potential use of TAF for pre-exposure prophylaxis (PrEP) to prevent human immunodeficiency virus infection. Macaques were exposed rectally to SHIV once per week for up to 19 weeks and received saline or FTC/TAF 24 hours before and 2 hours after each virus inoculation. All 6 controls were infected, while the 6 PrEP-treated animals were protected from infection. Our results support the clinical investigation of FTC/TAF for PrEP. JF - Journal of Infectious Diseases AU - Massud, Ivana AU - Mitchell, James AU - Babusis, Darius AU - Deyounks, Frank AU - Ray, Adrian S AU - Rooney, James F AU - Heneine, Walid AU - Miller, Michael D AU - Garcia-Lerma, J Gerardo AD - Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, jng5@cdc.gov Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 1058 EP - 1062 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 7 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Preexposure prophylaxis KW - tenofovir alafenamide KW - macaques, SHIV KW - Lymphoid cells KW - Rectum KW - Macaca KW - Retroviridae KW - Viruses KW - Simian/human immunodeficiency virus KW - Oral administration KW - tenofovir KW - Infection KW - Infectious diseases KW - Emtricitabine KW - prodrugs KW - Human immunodeficiency virus KW - Prophylaxis KW - Inoculation KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827913026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Chemoprophylaxis+With+Oral+Emtricitabine+and+Tenofovir+Alafenamide+Combination+Protects+Macaques+From+Rectal+Simian%2FHuman+Immunodeficiency+Virus+Infection&rft.au=Massud%2C+Ivana%3BMitchell%2C+James%3BBabusis%2C+Darius%3BDeyounks%2C+Frank%3BRay%2C+Adrian+S%3BRooney%2C+James+F%3BHeneine%2C+Walid%3BMiller%2C+Michael+D%3BGarcia-Lerma%2C+J+Gerardo&rft.aulast=Massud&rft.aufirst=Ivana&rft.date=2016-10-01&rft.volume=214&rft.issue=7&rft.spage=1058&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Lymphoid cells; Rectum; prodrugs; Emtricitabine; Oral administration; Inoculation; Prophylaxis; tenofovir; Infection; Infectious diseases; Viruses; Human immunodeficiency virus; Macaca; Retroviridae; Simian/human immunodeficiency virus DO - http://dx.doi.org/10.1093/infdis/jiw312 ER - TY - JOUR T1 - Performance of Dengue Diagnostic Tests in a Single-Specimen Diagnostic Algorithm AN - 1827921892; PQ0003670273 AB - Background.?Anti-dengue virus (DENV) immunoglobulin M (IgM) seroconversion has been the reference standard for dengue diagnosis. However, paired specimens are rarely obtained, and the interval for this testing negates its usefulness in guiding clinical case management. The presence of DENV viremia and appearance of IgM during the febrile phase of dengue provides the framework for dengue laboratory diagnosis by using a single serum specimen. Methods.?Archived paired serum specimens (n = 1234) from patients with laboratory-confirmed dengue from 2005 through 2011 were used to determine the diagnostic performance of real-time reverse transcription polymerase chain reaction (RT-PCR), for detection of DENV serotypes 1-4, and enzyme-linked immunosorbent assays (ELISAs), for detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM. Results.?During 1-3 days after illness onset, real-time RT-PCR and NS1 antigen testing detected 82%-69% and 90%-84% of cases, respectively, as viremia levels declined, while anti-DENV IgM ELISA detected 5%-41% of cases as antibody appeared. Over the 10-day period of the febrile phase of dengue, the cumulative effect of using these 3 types of tests in a diagnostic algorithm confirmed > or =90% of dengue cases. Conclusions.?The use of molecular or NS1 antigen tests to detect DENV and one to detect anti-DENV IgM in a single serum specimen collected during the first 10 days of illness accurately identified > or =90% of dengue primary and secondary cases. JF - Journal of Infectious Diseases AU - Hunsperger, Elizabeth A AU - Munoz-Jordan, Jorge AU - Beltran, Manuela AU - Colon, Candimar AU - Carrion, Jessica AU - Vazquez, Jesus AU - Acosta, Luz Nereida AU - Medina-Izquierdo, Juan F AU - Horiuchi, Kalanthe AU - Biggerstaff, Brad J AU - Margolis, Harold S AD - Dengue Branch, Division of Vector-Borne Diseases, Centers for Diseases Control and Prevention (CDC), San Juan, Puerto Rico, enh4@cdc.gov Y1 - 2016/09/15/ PY - 2016 DA - 2016 Sep 15 SP - 836 EP - 844 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 6 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - dengue virus KW - diagnostics KW - enzyme-linked immunoassay KW - dengue virus nonstructural protein 1 (NS1) KW - NS1 antigen detection KW - anti-dengue virus IgM KW - dengue virus molecular diagnostics KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - Viruses KW - Algorithms KW - Reverse transcription KW - Infectious diseases KW - Dengue KW - Nonstructural proteins KW - Proteins KW - Polymerase chain reaction KW - Seroconversion KW - Viremia KW - Immunoassays KW - Immunoglobulin M KW - H 0500:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827921892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Performance+of+Dengue+Diagnostic+Tests+in+a+Single-Specimen+Diagnostic+Algorithm&rft.au=Hunsperger%2C+Elizabeth+A%3BMunoz-Jordan%2C+Jorge%3BBeltran%2C+Manuela%3BColon%2C+Candimar%3BCarrion%2C+Jessica%3BVazquez%2C+Jesus%3BAcosta%2C+Luz+Nereida%3BMedina-Izquierdo%2C+Juan+F%3BHoriuchi%2C+Kalanthe%3BBiggerstaff%2C+Brad+J%3BMargolis%2C+Harold+S&rft.aulast=Hunsperger&rft.aufirst=Elizabeth&rft.date=2016-09-15&rft.volume=214&rft.issue=6&rft.spage=836&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Serotypes; Dengue; Nonstructural proteins; Algorithms; Seroconversion; Polymerase chain reaction; Viremia; Immunoglobulin M; Reverse transcription; Infectious diseases; Viruses; Proteins; Immunoassays DO - http://dx.doi.org/10.1093/infdis/jiw103 ER - TY - JOUR T1 - Notification following new positive HIV test results AN - 1827926653; PQ0003637315 AB - Client notification of a new HIV diagnosis is critical for timely access to treatment and reduction in behaviours associated with HIV infection. It is also an important input in HIV transmission and disease progression models. We used national, Centers for Disease Control and Prevention-funded HIV testing events data collected through the National HIV Prevention Program Monitoring and Evaluation system to update estimates of the proportion of newly identified HIV-positives notified of their status. We compared estimates from 2008 to 2010 across test technologies, settings, and HIV risk groups. In 2010, notification following a positive rapid test was 99.6% compared with 99.3% in 2008. Notification following a positive conventional test was 81.5% in 2010 compared with 80.8% in 2008. To realise the full promise of early HIV diagnosis and treatment for the prevention of additional HIV cases, efforts to ensure prompt notification following a new HIV diagnosis will be crucial. JF - International Journal of STD & AIDS AU - Huang, Ya-Lin A AU - Hutchinson, Angela B AU - Hollis, NaTasha D AU - Sansom, Stephanie L Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 868 EP - 872 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 10 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - HIV testing KW - receipt of test result KW - notification KW - rapid test KW - conventional test KW - Acquired immune deficiency syndrome KW - Data processing KW - Retroviridae KW - Disease control KW - Infection KW - Disease transmission KW - Models KW - Health risks KW - Prevention KW - Lentivirus KW - Risk groups KW - Sexually transmitted diseases KW - Technology KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827926653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Notification+following+new+positive+HIV+test+results&rft.au=Huang%2C+Ya-Lin+A%3BHutchinson%2C+Angela+B%3BHollis%2C+NaTasha+D%3BSansom%2C+Stephanie+L&rft.aulast=Huang&rft.aufirst=Ya-Lin&rft.date=2016-09-01&rft.volume=27&rft.issue=10&rft.spage=868&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462415598090 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 20 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Data processing; Disease control; Risk groups; Infection; Models; Disease transmission; Health risks; Acquired immune deficiency syndrome; Prevention; Sexually transmitted diseases; Technology; Lentivirus; Retroviridae DO - http://dx.doi.org/10.1177/0956462415598090 ER - TY - JOUR T1 - Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014 AN - 1827897379; PQ0003706336 AB - During August 2014, five high school students who had attended an outdoor education camp were hospitalized with a febrile illness, prompting further investigation. Ten total cases of tick-borne relapsing fever (TBRF) were identified-six cases confirmed by culture or visualization of spirochetes on blood smear and four probable cases with compatible symptoms (attack rate: 23%). All patients had slept in the campsite's only cabin. Before the camp, a professional pest control company had rodent proofed the cabin, but no acaricides had been applied. Cabin inspection after the camp found rodents and Ornithodoros ticks, the vector of TBRF. Blood samples from a chipmunk trapped near the cabin and from patients contained Borrelia hermsii with identical gene sequences (100% over 630 base pairs). Health departments in TBRF endemic areas should consider educating cabin owners and pest control companies to apply acaricides during or following rodent proofing, because ticks that lack rodents for a blood meal might feed on humans. JF - American Journal of Tropical Medicine and Hygiene AU - Jones, Jefferson M AU - Hranac, Carter R AU - Schumacher, Mare AU - Horn, Kim AU - Lee, Darlene M AU - Terriquez, Joel AU - Engelthaler, David M AU - Peoples, Marie AU - Corrigan, Jennifer AU - Replogle, Adam AU - Souders, Nina AU - Komatsu, Kenneth K AU - Nieto, Nathan C AD - Arizona Department of Health Services, Phoenix, Arizona, jjones10@cdc.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 546 EP - 550 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 3 SN - 0002-9637, 0002-9637 KW - Entomology Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Borrelia hermsii KW - Ixodidae KW - Camping KW - Cyclic AMP KW - Vectors KW - Pest control KW - Blood meals KW - Blood KW - Spirochetes KW - Schools KW - tick-borne diseases KW - USA, Arizona KW - Outbreaks KW - Acaricides KW - Inspection KW - Ornithodoros KW - Rodents KW - Adolescents KW - Hospitals KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827897379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Tick-Borne+Relapsing+Fever+Outbreak+Among+a+High+School+Football+Team+at+an+Outdoor+Education+Camping+Trip%2C+Arizona%2C+2014&rft.au=Jones%2C+Jefferson+M%3BHranac%2C+Carter+R%3BSchumacher%2C+Mare%3BHorn%2C+Kim%3BLee%2C+Darlene+M%3BTerriquez%2C+Joel%3BEngelthaler%2C+David+M%3BPeoples%2C+Marie%3BCorrigan%2C+Jennifer%3BReplogle%2C+Adam%3BSouders%2C+Nina%3BKomatsu%2C+Kenneth+K%3BNieto%2C+Nathan+C&rft.aulast=Jones&rft.aufirst=Jefferson&rft.date=2016-09-01&rft.volume=95&rft.issue=3&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0054 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Spirochetes; Cyclic AMP; tick-borne diseases; Vectors; Pest control; Blood meals; Acaricides; Blood; Schools; Camping; Outbreaks; Inspection; Adolescents; Rodents; Hospitals; Borrelia hermsii; Ixodidae; Ornithodoros; USA, Arizona DO - http://dx.doi.org/10.4269/ajtmh.16-0054 ER - TY - JOUR T1 - Monitoring for Human Papillomavirus Vaccine Impact Among Gay, Bisexual, and Other Men Who Have Sex With Men-United States, 2012-2014 AN - 1819139349; PQ0003621078 AB - Background. Gay, bisexual, and other men who have sex with men (MSM) are at high risk for human papillomavirus (HPV) infection; vaccination is recommended for US males, including MSM through age 26 years. We assessed evidence of HPV among vaccine-eligible MSM and transgender women to monitor vaccine impact. Methods. During 2012-2014, MSM aged 18-26 years at select clinics completed a computer-assisted self-interview regarding sexual behavior, human immunodeficiency virus (HIV) status, and vaccinations. Self-collected anal swab and oral rinse specimens were tested for HPV DNA (37 types) by L1 consensus polymerase chain reaction; serum was tested for HPV antibodies (4 types) by a multiplexed virus-like particle-based immunoglobulin G direct enzyme-linked immunosorbent assay. Results. Among 922 vaccine-eligible participants, the mean age was 23 years, and the mean number of lifetime sex partners was 37. Among 834 without HIV infection, any anal HPV was detected in 69.4% and any oral HPV in 8.4%, yet only 8.5% had evidence of exposure to all quadrivalent vaccine types. In multivariate analysis, HPV prevalence varied significantly (P< .05) by HIV status, sexual orientation, and lifetime number of sex partners, but not by race/ethnicity. Discussions. Most young MSM lacked evidence of current or past infection with all vaccine-type HPV types, suggesting that they could benefit from vaccination. The impact of vaccination among MSM may be assessed by monitoring HPV prevalence, including in self-collected specimens. JF - Journal of Infectious Diseases AU - Meites, Elissa AU - Gorbach, Pamina M AU - Gratzer, Beau AU - Panicker, Gitika AU - Steinau, Martin AU - Collins, Tom AU - Parrish, Adam AU - Randel, Cody AU - McGrath, Mark AU - Carrasco, Steven AD - Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, emeites@cdc.gov Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 689 EP - 696 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 5 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - epidemiological monitoring KW - homosexuality, male KW - papillomavirus infections KW - papillomavirus vaccines KW - Risk assessment KW - Age KW - Males KW - Viruses KW - Particulates KW - Homosexuality KW - Infection KW - Sexual behavior KW - Lentivirus KW - Infectious diseases KW - Multivariate analysis KW - Bisexuality KW - Risk factors KW - Polymerase chain reaction KW - Races KW - Ethnic groups KW - Sex KW - Enzyme-linked immunosorbent assay KW - Vaccination KW - Human behavior KW - Human immunodeficiency virus KW - Bisexual KW - DNA KW - Immunoglobulin G KW - Vaccines KW - Immunoassays KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819139349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Monitoring+for+Human+Papillomavirus+Vaccine+Impact+Among+Gay%2C+Bisexual%2C+and+Other+Men+Who+Have+Sex+With+Men-United+States%2C+2012-2014&rft.au=Meites%2C+Elissa%3BGorbach%2C+Pamina+M%3BGratzer%2C+Beau%3BPanicker%2C+Gitika%3BSteinau%2C+Martin%3BCollins%2C+Tom%3BParrish%2C+Adam%3BRandel%2C+Cody%3BMcGrath%2C+Mark%3BCarrasco%2C+Steven&rft.aulast=Meites&rft.aufirst=Elissa&rft.date=2016-09-01&rft.volume=214&rft.issue=5&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Age; Enzyme-linked immunosorbent assay; Infection; Vaccination; Sexual behavior; Multivariate analysis; Risk factors; Bisexual; Immunoglobulin G; Polymerase chain reaction; Vaccines; Ethnic groups; Races; Sex; Risk assessment; Males; Viruses; Homosexuality; Particulates; Human behavior; Infectious diseases; Bisexuality; DNA; Immunoassays; Lentivirus; Human immunodeficiency virus; Human papillomavirus DO - http://dx.doi.org/10.1093/infdis/jiw232 ER - TY - JOUR T1 - Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013 AN - 1819137212; PQ0003621083 AB - Background. Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006. Methods. Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping. Results. In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype. Conclusions. Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure. JF - Journal of Infectious Diseases AU - Bowen, Michael D AU - Mijatovic-Rustempasic, Slavica AU - Esona, Mathew D AU - Teel, Elizabeth N AU - Gautam, Rashi AU - Sturgeon, Michele AU - Azimi, Parvin H AU - Baker, Carol J AU - Bernstein, David I AU - Boom, Julie A AD - Centers for Disease Control and Prevention, Atlanta, Georgia, mkb6@cdc.gov Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 732 EP - 738 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 5 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - rotavirus KW - genotype KW - prevalence KW - surveillance KW - vaccine KW - Rotavirus KW - Pediatrics KW - Genotyping KW - Disease control KW - Enzymes KW - Genotypes KW - Enzyme immunoassay KW - USA KW - Prevention KW - Infectious diseases KW - Vaccines KW - Gastroenteritis KW - Immunoassays KW - Races KW - Emergency medical services KW - Hospitals KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819137212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Rotavirus+Strain+Trends+During+the+Postlicensure+Vaccine+Era%3A+United+States%2C+2008-2013&rft.au=Bowen%2C+Michael+D%3BMijatovic-Rustempasic%2C+Slavica%3BEsona%2C+Mathew+D%3BTeel%2C+Elizabeth+N%3BGautam%2C+Rashi%3BSturgeon%2C+Michele%3BAzimi%2C+Parvin+H%3BBaker%2C+Carol+J%3BBernstein%2C+David+I%3BBoom%2C+Julie+A&rft.aulast=Bowen&rft.aufirst=Michael&rft.date=2016-09-01&rft.volume=214&rft.issue=5&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Pediatrics; Genotyping; Disease control; Vaccines; Genotypes; Gastroenteritis; Races; Enzyme immunoassay; Hospitals; Prevention; Infectious diseases; Enzymes; Immunoassays; Emergency medical services; Rotavirus; USA DO - http://dx.doi.org/10.1093/infdis/jiw233 ER - TY - JOUR T1 - Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia AN - 1819136950; PQ0003621081 AB - Background. Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain. Methods. We assessed routinely collected epidemiologic data for MERS-CoV cases reported in Saudi Arabia during 1 January-30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing. Results. During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between clades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015. Discussions. Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission. JF - Journal of Infectious Diseases AU - Assiri, Abdullah M AU - Midgley, Claire M AU - Abedi, Glen R AU - Saeed, Abdulaziz Bin AU - Almasri, Malak M AU - Lu, Xiaoyan AU - Al-Abdely, Hail M AU - Abdalla, Osman AU - Mohammed, Mutaz AU - Algarni, Homoud S AD - Ministry of Health, ydk5@cdc.gov Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 712 EP - 721 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 5 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Middle East respiratory syndrome KW - MERS KW - coronavirus KW - MERS epidemiology KW - MERS transmission KW - MERS phylogeny KW - recombinant KW - Saudi Arabia KW - Risk assessment KW - Genomes KW - Data processing KW - Coronavirus KW - Viruses KW - Infectious diseases KW - Epidemiology KW - Risk factors KW - Middle East KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819136950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Epidemiology+of+a+Novel+Recombinant+Middle+East+Respiratory+Syndrome+Coronavirus+in+Humans+in+Saudi+Arabia&rft.au=Assiri%2C+Abdullah+M%3BMidgley%2C+Claire+M%3BAbedi%2C+Glen+R%3BSaeed%2C+Abdulaziz+Bin%3BAlmasri%2C+Malak+M%3BLu%2C+Xiaoyan%3BAl-Abdely%2C+Hail+M%3BAbdalla%2C+Osman%3BMohammed%2C+Mutaz%3BAlgarni%2C+Homoud+S&rft.aulast=Assiri&rft.aufirst=Abdullah&rft.date=2016-09-01&rft.volume=214&rft.issue=5&rft.spage=712&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Epidemiology; Risk factors; Risk assessment; Infectious diseases; Viruses; Coronavirus; Saudi Arabia; Middle East DO - http://dx.doi.org/10.1093/infdis/jiw236 ER - TY - JOUR T1 - Fentanyl Law Enforcement Submissions and Increases in Synthetic Opioid-Involved Overdose Deaths - 27 States, 2013-2014. AN - 1814682213; 27560775 AB - In March and October 2015, the Drug Enforcement Administration (DEA) and CDC, respectively, issued nationwide alerts identifying illicitly manufactured fentanyl (IMF) as a threat to public health and safety (1,2). IMF is unlawfully produced fentanyl, obtained through illicit drug markets, includes fentanyl analogs, and is commonly mixed with or sold as heroin (1,3,4). Starting in 2013, the production and distribution of IMF increased to unprecedented levels, fueled by increases in the global supply, processing, and distribution of fentanyl and fentanyl-precursor chemicals by criminal organizations (3). Fentanyl is a synthetic opioid 50-100 times more potent than morphine (2).* Multiple states have reported increases in fentanyl-involved overdose (poisoning) deaths (fentanyl deaths) (2). This report examined the number of drug products obtained by law enforcement that tested positive for fentanyl (fentanyl submissions) and synthetic opioid-involved deaths other than methadone (synthetic opioid deaths), which include fentanyl deaths and deaths involving other synthetic opioids (e.g., tramadol). Fentanyl deaths are not reported separately in national data. Analyses also were conducted on data from 27 states(†) with consistent death certificate reporting of the drugs involved in overdoses. Nationally, the number of fentanyl submissions and synthetic opioid deaths increased by 426% and 79%, respectively, during 2013-2014; among the 27 analyzed states, fentanyl submission increases were strongly correlated with increases in synthetic opioid deaths. Changes in fentanyl submissions and synthetic opioid deaths were not correlated with changes in fentanyl prescribing rates, and increases in fentanyl submissions and synthetic opioid deaths were primarily concentrated in eight states (high-burden states). Reports from six of the eight high-burden states indicated that fentanyl-involved overdose deaths were primarily driving increases in synthetic opioid deaths. Increases in synthetic opioid deaths among high-burden states disproportionately involved persons aged 15-44 years and males, a pattern consistent with previously documented IMF-involved deaths (5). These findings, combined with the approximate doubling in fentanyl submissions during 2014-2015 (from 5,343 to 13,882) (6), underscore the urgent need for a collaborative public health and law enforcement response. JF - MMWR. Morbidity and mortality weekly report AU - Gladden, R Matthew AU - Martinez, Pedro AU - Seth, Puja AD - Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Y1 - 2016/08/26/ PY - 2016 DA - 2016 Aug 26 SP - 837 EP - 843 VL - 65 IS - 33 KW - Street Drugs KW - 0 KW - Fentanyl KW - UF599785JZ KW - Index Medicus KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Opioid-Related Disorders -- mortality KW - Law Enforcement KW - Drug Overdose -- mortality KW - Street Drugs -- legislation & jurisprudence KW - Fentanyl -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814682213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+mortality+weekly+report&rft.atitle=Fentanyl+Law+Enforcement+Submissions+and+Increases+in+Synthetic+Opioid-Involved+Overdose+Deaths+-+27+States%2C+2013-2014.&rft.au=Gladden%2C+R+Matthew%3BMartinez%2C+Pedro%3BSeth%2C+Puja&rft.aulast=Gladden&rft.aufirst=R&rft.date=2016-08-26&rft.volume=65&rft.issue=33&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+mortality+weekly+report&rft.issn=1545-861X&rft_id=info:doi/10.15585%2Fmmwr.mm6533a2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-09 N1 - Date created - 2016-08-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.15585/mmwr.mm6533a2 ER - TY - JOUR T1 - A case-control study evaluating the role of internet meet-up sites and mobile telephone applications in influencing a syphilis outbreak: Multnomah County, Oregon, USA 2014 AN - 1827932577; PQ0003499222 AB - ObjectivesEarly syphilis in Multnomah County, Oregon, USA, increased 16-fold during 2007-2013. Cases predominantly occurred among men who have sex with men (MSM); 55% were HIV coinfected. We conducted a case-control study to evaluate the association between meeting sex partners online and early syphilis.MethodsCases subjects (cases) were Multnomah County resident, English speaking, MSM, aged greater than or equal to 18 years with laboratory-confirmed early syphilis reported 1 January to 31 December 2013. We recruited two MSM controls subjects (controls) per case, frequency matched by HIV status and age. Participants completed self-administered questionnaires. We performed multivariable logistic regression.ResultsSeventy per cent (40/57) of cases and 42% (50/119) of controls met partners online (p<0.001). Cases more frequently met partners online (adjusted OR (aOR)=3.0; 95% CI 1.2 to 6.7), controlling for presumptive confounders. Cases reported more partners than controls (medians 5, 2; p<0.001). When including number of partners, aOR decreased to 1.4 (95% CI 0.5 to 3.9).ConclusionsEarly syphilis was associated with meeting partners online. We believe this association may be related to number of sex partners acting as an intermediate variable between use of online resources to meet sex partners and early syphilis. Online meet-up sites might represent areas for public health interventions targeting at-risk individuals. JF - Sexually Transmitted Infections AU - DeSilva, Malini AU - Hedberg, Katrina AU - Robinson, Byron AU - Toevs, Kim AU - Neblett-Fanfair, Robyn AU - Petrosky, Emiko AU - Hariri, Susan AU - Schafer, Sean AD - Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, CDC, , Atlanta, Georgia, USA Y1 - 2016/08/17/ PY - 2016 DA - 2016 Aug 17 SP - 353 EP - 358 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 92 IS - 5 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - SYPHILIS KW - GAY MEN KW - PUBLIC HEALTH KW - Inventories KW - Lentivirus KW - Treponema pallidum KW - Cellular telephones KW - Syphilis KW - Internet KW - Sex KW - Public health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827932577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=A+case-control+study+evaluating+the+role+of+internet+meet-up+sites+and+mobile+telephone+applications+in+influencing+a+syphilis+outbreak%3A+Multnomah+County%2C+Oregon%2C+USA+2014&rft.au=DeSilva%2C+Malini%3BHedberg%2C+Katrina%3BRobinson%2C+Byron%3BToevs%2C+Kim%3BNeblett-Fanfair%2C+Robyn%3BPetrosky%2C+Emiko%3BHariri%2C+Susan%3BSchafer%2C+Sean&rft.aulast=DeSilva&rft.aufirst=Malini&rft.date=2016-08-17&rft.volume=92&rft.issue=5&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2015-052509 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Inventories; Cellular telephones; Syphilis; Internet; Public health; Sex; Lentivirus; Treponema pallidum DO - http://dx.doi.org/10.1136/sextrans-2015-052509 ER - TY - JOUR T1 - Varicella immunization requirements for US colleges: 2014-2015 academic year AN - 1811904197; PQ0003562904 AB - Objective: To obtain information on varicella prematriculation requirements in US colleges for undergraduate students during the 2014-2015 academic year. Participants: Health care professionals and member schools of the American College Health Association (ACHA). Methods: An electronic survey was sent to ACHA members regarding school characteristics and whether schools had policies in place requiring that students show proof of 2 doses of varicella vaccination for school attendance. Results: Only 27% (101/370) of schools had a varicella prematriculation requirement for undergraduate students. Only 68% of schools always enforced this requirement. Private schools, 4-year schools, northeastern schools, those with <5,000 students, and schools located in a state with a 2-dose varicella vaccine mandate were significantly more likely to have a varicella prematriculation requirement. Conclusions: A small proportion of US colleges have a varicella prematriculation requirement for varicella immunity. College vaccination requirements are an important tool for controlling varicella in these settings. JF - Journal of American College Health AU - Leung, Jessica AU - Marin, Mona AU - Leino, Victor AU - Even, Susan AU - Bialek, Stephanie R AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Y1 - 2016/08/17/ PY - 2016 DA - 2016 Aug 17 SP - 490 EP - 495 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 64 IS - 6 SN - 0744-8481, 0744-8481 KW - Physical Education Index KW - Schools KW - Private schools KW - College students KW - Objectives KW - Immune system KW - Higher education KW - College health KW - School health KW - Students KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811904197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+American+College+Health&rft.atitle=Varicella+immunization+requirements+for+US+colleges%3A+2014-2015+academic+year&rft.au=Leung%2C+Jessica%3BMarin%2C+Mona%3BLeino%2C+Victor%3BEven%2C+Susan%3BBialek%2C+Stephanie+R&rft.aulast=Leung&rft.aufirst=Jessica&rft.date=2016-08-17&rft.volume=64&rft.issue=6&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Journal+of+American+College+Health&rft.issn=07448481&rft_id=info:doi/10.1080%2F07448481.2016.1138481 LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Schools; College students; Private schools; Immune system; Objectives; Higher education; College health; School health; Students DO - http://dx.doi.org/10.1080/07448481.2016.1138481 ER - TY - JOUR T1 - The Evolution and Transmission of Epidemic GII.17 Noroviruses AN - 1811877107; PQ0003534620 AB - Background. In recent decades, the GII.4 norovirus genotype has predominated in epidemics worldwide and been associated with an increased rate of evolutionary change. In 2014, a novel GII.17 variant emerged and persisted, causing large outbreaks of gastroenteritis in China and sporadic infections globally. The origin, evolution, and transmission history of this new variant are largely unknown. Methods. We generated 103 full capsid and 8 whole-genome sequences of GII.17 strains collected between August 2013 and November 2015 in Guangdong, China. Phylogenetic analyses were performed by integrating our data with those for all publically available GII.17 sequences. Results. The novel emergent lineage GII.17_Kawasaki_2014 most likely originated from Africa around 2001 and evolved at a rate of 5.6 x 10 super(-3) substitutions/site/year. Within this lineage, a new variant containing several important amino acid changes emerged around August 2013 and caused extensive epidemics in 2014-2015. The phylodynamic and epidemic history of the GII.17_Kawasaki lineage shows similarities with the pattern observed for GII.4 norovirus evolution. Virus movements from Hong Kong to neighboring coastal cities were frequently observed. Conclusions. Our results provide new insights into GII.17 norovirus evolution and transmission and highlight the potential for a rare norovirus genotype to rapidly replace existing strains and cause local epidemics. JF - Journal of Infectious Diseases AU - Lu, Jing AU - Fang, Lin AU - Zheng, Huanying AU - Lao, Jiaqian AU - Yang, Fen AU - Sun, Limei AU - Xiao, Jianpeng AU - Lin, Jinyan AU - Song, Tie AU - Ni, Tao AD - Guangdong Provincial Center for Disease Control and Prevention Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 556 EP - 564 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 4 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Health & Safety Science Abstracts KW - norovirus KW - phylogenetic KW - phylogeographic KW - epidemic KW - virus transmission KW - Historical account KW - Amino acids KW - Viruses KW - Norovirus KW - Genotypes KW - Infection KW - Cities KW - Infectious diseases KW - Africa KW - China, People's Rep. KW - Outbreaks KW - Gastroenteritis KW - ISEW, China, People's Rep., Hong Kong KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811877107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=The+Evolution+and+Transmission+of+Epidemic+GII.17+Noroviruses&rft.au=Lu%2C+Jing%3BFang%2C+Lin%3BZheng%2C+Huanying%3BLao%2C+Jiaqian%3BYang%2C+Fen%3BSun%2C+Limei%3BXiao%2C+Jianpeng%3BLin%2C+Jinyan%3BSong%2C+Tie%3BNi%2C+Tao&rft.aulast=Lu&rft.aufirst=Jing&rft.date=2016-08-15&rft.volume=214&rft.issue=4&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Cities; Historical account; Amino acids; Infectious diseases; Viruses; Outbreaks; Genotypes; Gastroenteritis; Infection; Norovirus; Africa; China, People's Rep.; ISEW, China, People's Rep., Hong Kong DO - http://dx.doi.org/10.1093/infdis/jiw208 ER - TY - JOUR T1 - Can you really swim? Validation of self and parental reports of swim skill with an inwater swim test among children attending community pools in Washington State AN - 1811885076; PQ0003499170 AB - BackgroundDrowning is the second leading cause of unintentional injury death among US children. Multiple studies describe decreased drowning risk among children possessing some swim skills. Current surveillance for this protective factor is self/proxy-reported swim skill rather than observed inwater performance; however, children's self-report or parents' proxy report of swim skill has not been validated. This is the first US study to evaluate whether children or parents can validly report a child's swim skill. It also explores which swim skill survey measure(s) correlate with children's inwater swim performance.MethodsFor this cross-sectional convenience-based sample, pilot study, child/parent dyads (N=482) were recruited at three outdoor public pools in Washington State. Agreement between measures of self-reports and parental-reports of children's swim skill was assessed via paired analyses, and validated by inwater swim test results.ResultsParticipants were representative of pool's patrons (ie, non-Hispanic White, highly educated, high income). There was agreement in child/parent dyads' reports of the following child swim skill measures: 'ever taken swim lessons', perceived 'good swim skills' and 'comfort in water over head'. Correlation analyses suggest that reported 'good swim skills' was the best survey measure to assess a child's swim skill-best if the parent was the informant (r=0.25-0.47). History of swim lessons was not significantly correlated with passing the swim test.ConclusionsReported 'good swim skills' was most correlated with observed swim skill. Reporting 'yes' to 'ever taken swim lessons' did not correlate with swim skill. While non-generalisable, findings can help inform future studies. JF - Injury Prevention AU - Mercado, Melissa C AU - Quan, Linda AU - Bennett, Elizabeth AU - Gilchrist, Julie AU - Levy, Benjamin A AU - Robinson, Candice L AU - Wendorf, Kristen AU - Gangan Fife, Maria Aurora AU - Stevens, Mark R AU - Lee, Robin AD - Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC, , Atlanta, Georgia, USA Y1 - 2016/08/12/ PY - 2016 DA - 2016 Aug 12 SP - 253 EP - 260 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 22 IS - 4 SN - 1353-8047, 1353-8047 KW - Physical Education Index; Health & Safety Science Abstracts KW - Risk assessment KW - Skill tests KW - Mortality KW - Historical account KW - Drowning KW - Injuries KW - Preventive health KW - Surveys KW - INE, USA, Washington KW - Children KW - Water KW - Income KW - Prevention KW - Risk factors KW - Analysis KW - Performance KW - Passing KW - H 11000:Diseases/Injuries/Trauma KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Can+you+really+swim%3F+Validation+of+self+and+parental+reports+of+swim+skill+with+an+inwater+swim+test+among+children+attending+community+pools+in+Washington+State&rft.au=Mercado%2C+Melissa+C%3BQuan%2C+Linda%3BBennett%2C+Elizabeth%3BGilchrist%2C+Julie%3BLevy%2C+Benjamin+A%3BRobinson%2C+Candice+L%3BWendorf%2C+Kristen%3BGangan+Fife%2C+Maria+Aurora%3BStevens%2C+Mark+R%3BLee%2C+Robin&rft.aulast=Mercado&rft.aufirst=Melissa&rft.date=2016-08-12&rft.volume=22&rft.issue=4&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041680 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Skill tests; Injuries; Preventive health; Analysis; Surveys; Performance; Children; Passing; Water; Risk assessment; Historical account; Mortality; Prevention; Drowning; Risk factors; Income; INE, USA, Washington DO - http://dx.doi.org/10.1136/injuryprev-2015-041680 ER - TY - JOUR T1 - Pathology of congenital Zika syndrome in Brazil: a case series AN - 1827928282; PQ0003629552 AB - Background Zika virus is an arthropod-borne virus that is a member of the family Flaviviridae transmitted mainly by mosquitoes of the genus Aedes. Although usually asymptomatic, infection can result in a mild and self-limiting illness characterised by fever, rash, arthralgia, and conjunctivitis. An increase in the number of children born with microcephaly was noted in 2015 in regions of Brazil with high transmission of Zika virus. More recently, evidence has been accumulating supporting a link between Zika virus and microcephaly. Here, we describe findings from three fatal cases and two spontaneous abortions associated with Zika virus infection. Methods In this case series, formalin-fixed paraffin-embedded tissue samples from five cases, including two newborn babies with microcephaly and severe arthrogryposis who died shortly after birth, one 2-month-old baby, and two placentas from spontaneous abortions, from Brazil were submitted to the Infectious Diseases Pathology Branch at the US Centers for Disease Control and Prevention (Atlanta, GA, USA) between December, 2015, and March, 2016. Specimens were assessed by histopathological examination, immunohistochemical assays using a mouse anti-Zika virus antibody, and RT-PCR assays targeting the NS5 and envelope genes. Amplicons of RT-PCR positive cases were sequenced for characterisation of strains. Findings Viral antigens were localised to glial cells and neurons and associated with microcalcifications in all three fatal cases with microcephaly. Antigens were also seen in chorionic villi of one of the first trimester placentas. Tissues from all five cases were positive for Zika virus RNA by RT-PCR, and sequence analyses showed highest identities with Zika virus strains isolated from Brazil during 2015. Interpretation These findings provide strong evidence of a link between Zika virus infection and different congenital central nervous system malformations, including microcephaly as well as arthrogryposis and spontaneous abortions. Funding None. JF - Lancet AU - Martines, Roosecelis Brasil AU - Bhatnagar, Julu AU - de Oliveira Ramos, Ana Maria AU - Davi, Helaine Pompeia Freire AU - Iglezias, Silvia D'Andretta AU - Kanamura, Cristina Takami AU - Keating, M Kelly AU - Hale, Gillian AU - Silva-Flannery, Luciana AU - Muehlenbachs, Atis AU - Ritter, Jana AU - Gary, Joy AU - Rollin, Dominique AU - Goldsmith, Cynthia S AU - Reagan-Steiner, Sarah AU - Ermias, Yokabed AU - Suzuki, Tadaki AU - Luz, Kleber G AU - de Oliveira, Wanderson Kleber AU - Lanciotti, Robert AU - Lambert, Amy AU - Shieh, Wun-Ju AU - Zaki, Sherif R AD - Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Atlanta, GA, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 898 EP - 904 PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands VL - 388 IS - 10047 SN - 0140-6736, 0140-6736 KW - Toxicology Abstracts KW - Central nervous system KW - Aedes KW - Zika virus KW - Nucleotide sequence KW - Abortion KW - Disease control KW - RNA viruses KW - Conjunctivitis KW - Children KW - Flaviviridae KW - Arthrogryposis KW - Fever KW - Exanthema KW - Antibodies KW - Envelopes KW - Infectious diseases KW - RNA KW - Neurotransmission KW - Microencephaly KW - Placenta KW - Congenital defects KW - Polymerase chain reaction KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827928282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Pathology+of+congenital+Zika+syndrome+in+Brazil%3A+a+case+series&rft.au=Martines%2C+Roosecelis+Brasil%3BBhatnagar%2C+Julu%3Bde+Oliveira+Ramos%2C+Ana+Maria%3BDavi%2C+Helaine+Pompeia+Freire%3BIglezias%2C+Silvia+D%27Andretta%3BKanamura%2C+Cristina+Takami%3BKeating%2C+M+Kelly%3BHale%2C+Gillian%3BSilva-Flannery%2C+Luciana%3BMuehlenbachs%2C+Atis%3BRitter%2C+Jana%3BGary%2C+Joy%3BRollin%2C+Dominique%3BGoldsmith%2C+Cynthia+S%3BReagan-Steiner%2C+Sarah%3BErmias%2C+Yokabed%3BSuzuki%2C+Tadaki%3BLuz%2C+Kleber+G%3Bde+Oliveira%2C+Wanderson+Kleber%3BLanciotti%2C+Robert%3BLambert%2C+Amy%3BShieh%2C+Wun-Ju%3BZaki%2C+Sherif+R&rft.aulast=Martines&rft.aufirst=Roosecelis&rft.date=2016-08-01&rft.volume=388&rft.issue=10047&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=01406736&rft_id=info:doi/10.1016%2FS0140-6736%2816%2930883-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 29 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Central nervous system; Abortion; Nucleotide sequence; Disease control; RNA viruses; Conjunctivitis; Children; Arthrogryposis; Fever; Exanthema; Antibodies; Envelopes; Neurotransmission; RNA; Infectious diseases; Microencephaly; Placenta; Polymerase chain reaction; Congenital defects; Aedes; Zika virus; Flaviviridae DO - http://dx.doi.org/10.1016/S0140-6736(16)30883-2 ER - TY - JOUR T1 - Evaluation of the Impact of the Revised National Institute for Occupational Safety and Health Lifting Equation AN - 1827890315; PQ0003686890 AB - Objective: The objective of this article is to evaluate the impact of the Revised National Institute for Occupational Safety and Health Lifting Equation (RNLE). Background: The RNLE has been used extensively as a risk assessment method for prevention of low back pain (LBP). However, the impact of the RNLE has not been documented. Methods: A systematic review of the literature on the RNLE was conducted. The review consisted of three parts: characterization of the RNLE publications, assessment of the impact of the RNLE, and evaluation of the influences of the RNLE on ergonomic standards. The literature for assessing the impact was categorized into four research areas: methodology, laboratory, field, and risk assessment studies using the Lifting Index (LI) or Composite LI (CLI), both of which are the products of the RNLE. Results: The impact of the RNLE has been both widespread and influential. We found 24 studies that examined the criteria used to define lifting capacity used by the RNLE, 28 studies that compared risk assessment methods for identifying LBP, 23 studies that found the RNLE useful in identifying the risk of LBP with different work populations, and 13 studies on the relationship between LI/CLI and LBP outcomes. We also found evidence on the adoption of the RNLE as an ergonomic standard for use by various local, state, and international entities. Conclusion: The review found 13 studies that link LI/CLI to adverse LBP outcomes. These studies showed a positive relationship between LI/CLI metrics and the severity of LBP outcomes. JF - Human Factors AU - Lu, Ming-Lun AU - Putz-Anderson, Vern AU - Garg, Arun AU - Davis, Kermit G AD - Taft Laboratories, Cincinnati, Ohio, mlu@cdc.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 667 EP - 682 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 USA VL - 58 IS - 5 SN - 0018-7208, 0018-7208 KW - Health & Safety Science Abstracts KW - Revised NIOSH Lifting Equation KW - lifting index KW - manual lifting KW - low back pain KW - impact KW - Risk assessment KW - Prevention KW - Risk factors KW - Occupational safety KW - Human factors KW - Low back pain KW - Ergonomics KW - Working conditions KW - International standardization KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors&rft.atitle=Evaluation+of+the+Impact+of+the+Revised+National+Institute+for+Occupational+Safety+and+Health+Lifting+Equation&rft.au=Lu%2C+Ming-Lun%3BPutz-Anderson%2C+Vern%3BGarg%2C+Arun%3BDavis%2C+Kermit+G&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2016-08-01&rft.volume=58&rft.issue=5&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Human+Factors&rft.issn=00187208&rft_id=info:doi/10.1177%2F0018720815623894 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 109 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Prevention; Risk factors; Occupational safety; Low back pain; Human factors; Working conditions; Ergonomics; International standardization DO - http://dx.doi.org/10.1177/0018720815623894 ER - TY - JOUR T1 - Rift Valley fever virus: Unanswered questions AN - 1815701943; PQ0003565030 AB - This mosquito-borne pathogen of humans and animals respects no international or geographic boundaries. It is currently found in parts of Africa and the Arabian Peninsula where periodic outbreaks of severe and fatal disease occur, and threatens to spread into other geographic regions. In recent years, modern molecular techniques have led to many breakthroughs deepening our understanding of the mechanisms of RVFV virulence, phylogenetics, and the creation of several next-generation vaccine candidates. Despite tremendous progress in these areas, other challenges remain in RVF disease pathogenesis, the virus life-cycle, and outbreak response preparedness that deserve our attention. Here we discuss and highlight ten key knowledge gaps and challenges in RVFV research. Answers to these key questions may lead to the development of new effective therapeutics and enhanced control strategies for this serious human and veterinary health threat. JF - Antiviral Research AU - Bird, Brian H AU - McElroy, Anita K AD - Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 274 EP - 280 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 132 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Rift Valley fever virus KW - Zoonoses KW - Epizootic KW - Reservoir KW - Mosquito KW - Arbovirus KW - Virulence KW - Phylogeny KW - Boundaries KW - Rift Valley fever KW - Vaccines KW - Pathogens KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815701943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=Rift+Valley+fever+virus%3A+Unanswered+questions&rft.au=Bird%2C+Brian+H%3BMcElroy%2C+Anita+K&rft.aulast=Bird&rft.aufirst=Brian&rft.date=2016-08-01&rft.volume=132&rft.issue=&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2016.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Phylogeny; Virulence; Boundaries; Rift Valley fever; Pathogens; Vaccines; Rift Valley fever virus DO - http://dx.doi.org/10.1016/j.antiviral.2016.07.005 ER - TY - JOUR T1 - Prevalence and Diversity of Bartonella Species in Rodents from Georgia (Caucasus) AN - 1815695313; PQ0003607539 AB - Bartonella infections are widespread and highly prevalent in rodents. Several rodent-associated Bartonella species have been related to human diseases. Recently, Bartonella species was reported as the etiology of a human case in the country of Georgia (Caucasus). However, information on Bartonella in rodents in Georgia is absent. Rodent hearts were collected from Georgia to investigate the presence and diversity of Bartonella species. Bartonella bacteria were cultured from 37.2% (16/43) of rodents examined, while Bartonella DNA was detected in 41.2% (28/68) of rodents by polymerase chain reaction targeting citrate synthase (gltA) gene. Sequences of gltA showed that rodents in this region harbored multiple Bartonella strains, including Bartonella elizabethae, Bartonella tribocorum, Bartonella grahamii, and an unknown genogroup. The first three Bartonella species, known to be rat-associated and human cases linked, were commonly observed in wood mice (Apodemus[Sylvaemus] uralensis) (5/8 positive with B. elizabethae and B. tribocorum) and social voles (Microtus socialis) (4/6 positive with B. grahamii and B. elizabethae) in this study. The frequent distribution of these Bartonella species suggests that they may contribute to unidentified clinical infections. The unknown genogroup was observed in 24 Bartonella isolates and/or DNA extracts from heart tissues, all of which were obtained from Libyan jirds(Meriones libycus). Further characterization of the bacterial cultures based on sequence analysis of four additional genes (ftsZ, nuoG, rpoB, and ssrA) supported that the jird-associated Bartonella strains comprise a distinct monophyletic clade. The impact of this bacterium on wildlife and human health needs to be determined. JF - American Journal of Tropical Medicine and Hygiene AU - Malania, Lile AU - Bai, Ying AU - Osikowicz, Lynn M AU - Tsertsvadze, Nikoloz AU - Katsitadze, Guram AU - Imnadze, Paata AU - Kosoy, Michael AD - General Bacteriology Laboratory, National Center for Disease Control and Public Health, Tbilisi, Republic of Georgia, bby5@cdc.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 466 EP - 471 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 2 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Heart KW - Bacteria KW - Etiology KW - Bartonella elizabethae KW - Bartonella KW - Wildlife KW - Bartonella grahamii KW - Wood KW - Mice KW - Infection KW - Microtus socialis KW - ASW, USA, Georgia KW - gltA gene KW - Species diversity KW - DNA KW - Polymerase chain reaction KW - Rodents KW - RpoB protein KW - Citric acid KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - K 03310:Genetics & Taxonomy KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815695313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Prevalence+and+Diversity+of+Bartonella+Species+in+Rodents+from+Georgia+%28Caucasus%29&rft.au=Malania%2C+Lile%3BBai%2C+Ying%3BOsikowicz%2C+Lynn+M%3BTsertsvadze%2C+Nikoloz%3BKatsitadze%2C+Guram%3BImnadze%2C+Paata%3BKosoy%2C+Michael&rft.aulast=Malania&rft.aufirst=Lile&rft.date=2016-08-01&rft.volume=95&rft.issue=2&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Heart; Etiology; gltA gene; Wildlife; Polymerase chain reaction; Infection; RpoB protein; Citric acid; Bacteria; Species diversity; DNA; Wood; Mice; Rodents; Microtus socialis; Bartonella elizabethae; Bartonella; Bartonella grahamii; ASW, USA, Georgia DO - http://dx.doi.org/10.4269/ajtmh.16-0041 ER - TY - JOUR T1 - Prevalence of Hepatitis B Virus Infection in Kenya, 2007 AN - 1815691170; PQ0003607517 AB - Current estimates put the prevalence of hepatitis B virus (HBV) infection in Kenya at 5-8%. We determined the HBV infection prevalence in the human immunodeficiency virus (HIV)-negative Kenyan adult and adolescent population based on samples collected from a national survey. We analyzed data from HIV-negative participants in the 2007 Kenya AIDS Indicator Survey to estimate the HBV infection prevalence. We defined past or present HBV infection as presence of total hepatitis B core antibody (HBcAb), and chronic HBV infection (CHBI) as presence of both total HBcAb and hepatitis B surface antigen (HBsAg). We calculated crude and adjusted odds of HBV infection by demographic characteristics and risk factors using logistic regression analyses. Of 1,091 participants aged 15-64 years, approximately 31.5% (95% confidence interval [CI] = 28.0-35.3%) had exposure to HBV, corresponding to approximately 6.1 million (CI = 5.4-6.8 million) with past or present HBV infection. The estimated prevalence of CHBI was 2.1% (95% CI = 1.4-3.1%), corresponding to approximately 398,000 (CI = 261,000-602,000) with CHBI. CHBI is a major public health problem in Kenya, affecting approximately 400,000 persons. Knowing the HBV infection prevalence at baseline is important for planning and public health policy decision making and for monitoring the impact of viral hepatitis prevention programs. JF - American Journal of Tropical Medicine and Hygiene AU - Ly, Kathleen N AU - Kim, Andrea A AU - Umuro, Mamo AU - Drobenuic, Jan AU - Williamson, John M AU - Montgomery, Joel M AU - Fields, Barry S AU - Teshale, Eyasu H AD - Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, kathleen.ly@cdc.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 348 EP - 353 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 2 SN - 0002-9637, 0002-9637 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Acquired immune deficiency syndrome KW - Viruses KW - Hepatitis B surface antigen KW - Infection KW - Public health KW - Demography KW - Kenya KW - Lentivirus KW - Risk factors KW - Regression analysis KW - Adolescents KW - Data processing KW - Hepatitis B virus KW - Adolescence KW - Hepatitis KW - Decision making KW - Prevention KW - Antibodies KW - Human immunodeficiency virus KW - Chronic infection KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815691170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Prevalence+of+Hepatitis+B+Virus+Infection+in+Kenya%2C+2007&rft.au=Ly%2C+Kathleen+N%3BKim%2C+Andrea+A%3BUmuro%2C+Mamo%3BDrobenuic%2C+Jan%3BWilliamson%2C+John+M%3BMontgomery%2C+Joel+M%3BFields%2C+Barry+S%3BTeshale%2C+Eyasu+H&rft.aulast=Ly&rft.aufirst=Kathleen&rft.date=2016-08-01&rft.volume=95&rft.issue=2&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0059 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Demography; Decision making; Antibodies; Acquired immune deficiency syndrome; Data processing; Risk factors; Adolescence; Chronic infection; Regression analysis; Hepatitis B surface antigen; Public health; Hepatitis; Prevention; Viruses; Infection; Adolescents; Lentivirus; Hepatitis B virus; Human immunodeficiency virus; Kenya DO - http://dx.doi.org/10.4269/ajtmh.16-0059 ER - TY - JOUR T1 - Features in Grocery Stores that Motivate Shoppers to Buy Healthier Foods, ConsumerStyles 2014 AN - 1808733010; PQ0003390576 AB - We examined nine features in grocery stores shoppers reported motivated them to purchase more healthful foods in the past month. Features were compiled from common supermarket practices for each of the 4 Ps of marketing: pricing, placement, promotion, and product. We examined percentages of the features overall and by shopping frequency using Chi square tests from a 2014 cross sectional web-based health attitudes and behaviors survey, ConsumerStyles. The survey was fielded from June to July in 2014. Participants were part of a market research consumer panel that were randomly recruited by probability-based sampling using address-based sampling methods to achieve a sample representative of the U.S. population. Data from 4242 adults ages 18 and older were analyzed. About 44 % of respondents indicated at least one feature motivated them to purchase more healthful foods. Top choices included in-store coupons or specials (20.1 %), availability of convenient, ready-to-eat more healthful foods (18.8 %), product labels or advertising on packages (15.2 %), and labels or signs on shelves that highlighted more healthful options (14.6 %). Frequent shoppers reported being motivated to purchase more healthful foods by in-store tastings/recipe demonstrations and coupons/specials more often than infrequent shoppers. Enhancing the visibility and appeal of more healthful food items in grocery stores may help improve dietary choices in some populations but additional research is needed to identify the most effective strategies for interventions. JF - Journal of Community Health AU - Moore, Latetia V AU - Pinard, Courtney A AU - Yaroch, Amy L AD - Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE MS F-77, Atlanta, GA, 30341, USA, lvmoore@cdc.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 812 EP - 817 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 41 IS - 4 SN - 0094-5145, 0094-5145 KW - Health & Safety Science Abstracts KW - Diets KW - Attitudes KW - Pricing KW - Age KW - Marketing KW - Intervention KW - Visibility KW - Advertising KW - Sampling methods KW - H 9000:Consumer and Recreation Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808733010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Features+in+Grocery+Stores+that+Motivate+Shoppers+to+Buy+Healthier+Foods%2C+ConsumerStyles+2014&rft.au=Moore%2C+Latetia+V%3BPinard%2C+Courtney+A%3BYaroch%2C+Amy+L&rft.aulast=Moore&rft.aufirst=Latetia&rft.date=2016-08-01&rft.volume=41&rft.issue=4&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-016-0158-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 23 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Diets; Age; Pricing; Attitudes; Marketing; Intervention; Visibility; Advertising; Sampling methods DO - http://dx.doi.org/10.1007/s10900-016-0158-x ER - TY - JOUR T1 - Will Culling White-Tailed Deer Prevent Lyme Disease? AN - 1808670749; PQ0003393991 AB - White-tailed deer play an important role in the ecology of Lyme disease. In the United States, where the incidence and geographic range of Lyme disease continue to increase, reduction of white-tailed deer populations has been proposed as a means of preventing human illness. The effectiveness of this politically sensitive prevention method is poorly understood. We summarize and evaluate available evidence regarding the effect of deer reduction on vector tick abundance and human disease incidence. Elimination of deer from islands and other isolated settings can have a substantial impact on the reproduction of blacklegged ticks, while reduction short of complete elimination has yielded mixed results. To date, most studies have been conducted in ecologic situations that are not representative to the vast majority of areas with high human Lyme disease risk. Robust evidence linking deer control to reduced human Lyme disease risk is lacking. Currently, there is insufficient evidence to recommend deer population reduction as a Lyme disease prevention measure, except in specific ecologic circumstances. JF - Zoonoses and Public Health AU - Kugeler, K J AU - Jordan, R A AU - Schulze, T L AU - Griffith, K S AU - Mead, P S AD - National Center for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 337 EP - 345 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 63 IS - 5 SN - 1863-1959, 1863-1959 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Human diseases KW - Abundance KW - Disease control KW - Hosts KW - Public health KW - Disease transmission KW - Ecology KW - Islands KW - Deer KW - Lyme disease KW - Ixodidae KW - Vectors KW - Methodology KW - USA KW - Prevention KW - Zoonoses KW - Culling KW - Reviews KW - Borrelia KW - Reproduction KW - J 02410:Animal Diseases KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - Q1 08485:Species interactions: pests and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808670749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zoonoses+and+Public+Health&rft.atitle=Will+Culling+White-Tailed+Deer+Prevent+Lyme+Disease%3F&rft.au=Kugeler%2C+K+J%3BJordan%2C+R+A%3BSchulze%2C+T+L%3BGriffith%2C+K+S%3BMead%2C+P+S&rft.aulast=Kugeler&rft.aufirst=K&rft.date=2016-08-01&rft.volume=63&rft.issue=5&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Zoonoses+and+Public+Health&rft.issn=18631959&rft_id=info:doi/10.1111%2Fzph.12245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Ecology; Human diseases; Culling; Disease control; Vectors; Hosts; Methodology; Disease transmission; Public health; Zoonoses; Islands; Reviews; Abundance; Reproduction; Lyme disease; Prevention; Deer; Ixodidae; Borrelia; USA DO - http://dx.doi.org/10.1111/zph.12245 ER - TY - JOUR T1 - Suicide among people with epilepsy: A population-based analysis of data from the U.S. National Violent Death Reporting System, 17 states, 2003-2011. AN - 1808387736; 27372961 AB - This study analyzed suicide data in the general population from the U.S. National Violent Death Reporting System (NVDRS) to investigate suicide burden among those with epilepsy and risk factors associated with suicide and to suggest measures to prevent suicide among people with epilepsy. The NVDRS is a multiple-state, population-based, active surveillance system that collects information on violent deaths including suicide. Among people 10years old and older, we identified 972 suicide cases with epilepsy and 81,529 suicide cases without epilepsy in 17 states from 2003 through 2011. We estimated their suicide rates, evaluated suicide risk among people with epilepsy, and investigated suicide risk factors specific to epilepsy by comparing those with and without epilepsy. In 16 of the 17 states providing continual data from 2005 through 2011, we also compared suicide trends in people with epilepsy (n=833) and without epilepsy (n=68,662). From 2003 through 2011, the estimated annual suicide mortality rate among people with epilepsy was 16.89/100,000 per persons, 22% higher than that in the general population. Compared with those without epilepsy, those with epilepsy were more likely to have died from suicide in houses, apartments, or residential institutions (81% vs. 76%, respectively) and were twice as likely to poison themselves (38% vs. 17%) (P<0.01). More of those with epilepsy aged 40-49 died from suicide than comparably aged persons without epilepsy (29% vs. 22%) (P<0.01). The proportion of suicides among those with epilepsy increased steadily from 2005 through 2010, peaking significantly in 2010 before falling. For the first time, the suicide rate among people with epilepsy in a large U.S. general population was estimated, and the suicide risk exceeded that in the general population. Suicide prevention efforts should target people with epilepsy 40-49years old. Additional preventive efforts include reducing the availability or exposure to poisons, especially at home, and supporting other evidence-based programs to reduce mental illness comorbidity associated with suicide. Published by Elsevier Inc. JF - Epilepsy & behavior : E&B AU - Tian, Niu AU - Cui, Wanjun AU - Zack, Matthew AU - Kobau, Rosemarie AU - Fowler, Katherine A AU - Hesdorffer, Dale C AD - Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Electronic address: vii9@cdc.gov. ; Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. ; Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. ; GH Sergievsky Center and Mailman School of Public Health, Columbia University, New York, NY 10032, United States. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 210 EP - 217 VL - 61 KW - Index Medicus KW - Epidemiology KW - Epilepsy KW - Suicide KW - Population KW - Rate UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808387736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+%26+behavior+%3A+E%26B&rft.atitle=Suicide+among+people+with+epilepsy%3A+A+population-based+analysis+of+data+from+the+U.S.+National+Violent+Death+Reporting+System%2C+17+states%2C+2003-2011.&rft.au=Tian%2C+Niu%3BCui%2C+Wanjun%3BZack%2C+Matthew%3BKobau%2C+Rosemarie%3BFowler%2C+Katherine+A%3BHesdorffer%2C+Dale+C&rft.aulast=Tian&rft.aufirst=Niu&rft.date=2016-08-01&rft.volume=61&rft.issue=&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Epilepsy+%26+behavior+%3A+E%26B&rft.issn=1525-5069&rft_id=info:doi/10.1016%2Fj.yebeh.2016.05.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yebeh.2016.05.028 ER - TY - JOUR T1 - Associations of Teen Dating Violence Victimization With School Violence and Bullying Among US High School Students AN - 1801372475 AB - BACKGROUND Teen dating violence (TDV) negatively impacts health, mental and physical well-being, and school performance. METHODS Data from a nationally representative sample of high school students participating in the Centers for Disease Control and Prevention (CDC)'s 2013 Youth Risk Behavior Survey (YRBS) are used to demonstrate associations of physical and sexual TDV with school violence-related experiences and behaviors, including bullying victimization. Bivariate and adjusted sex-stratified regressions assessed relationships between TDV and school violence-related experiences and behaviors. RESULTS Compared to students not reporting TDV, those experiencing both physical and sexual TDV were more likely to report carrying a weapon at school, missing school because they felt unsafe, being threatened or injured with a weapon on school property, having a physical fight at school, and being bullied on school property. CONCLUSIONS School-based prevention efforts should target multiple forms of violence. JF - The Journal of School Health AU - Vivolo-Kantor, Alana M AU - Olsen, Emily O'Malley AU - Bacon, Sarah AD - Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Division of Violence Prevention, Atlanta, GA ; Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Division of Adolescent and School Health, Atlanta, GA ; Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, Division of Unintentional Injury Prevention, Atlanta, GA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 620 EP - 627 CY - Kent PB - Wiley Subscription Services, Inc. VL - 86 IS - 8 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Behavior KW - Teenagers KW - Violence KW - Bullying KW - School violence KW - Victimization KW - Academic achievement KW - Mental health KW - Wellbeing KW - Unsafe KW - Risk behaviour KW - Health status KW - Gender violence KW - Preventive programmes KW - School based KW - Dating KW - Property KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801372475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=Associations+of+Teen+Dating+Violence+Victimization+With+School+Violence+and+Bullying+Among+US+High+School+Students&rft.au=Vivolo-Kantor%2C+Alana+M%3BOlsen%2C+Emily+O%27Malley%3BBacon%2C+Sarah&rft.aulast=Vivolo-Kantor&rft.aufirst=Alana&rft.date=2016-08-01&rft.volume=86&rft.issue=8&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12412 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Centers for Disease Control & Prevention--CDC N1 - Copyright - © 2016, American School Health Association N1 - Last updated - 2016-08-16 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/josh.12412 ER - TY - JOUR T1 - Parenting Among Adolescents and Young Adults with Human Immunodeficiency Virus Infection in the United States: Challenges, Unmet Needs, and Opportunities AN - 1859486690; PQ0003988395 AB - Given the realistic expectations of HIV-infected adolescents and young adults (AYA) to have children and start families, steps must be taken to ensure that youth are prepared to deal with the challenges associated with their HIV and parenting. Literature reviews were conducted to identify published research and practice guidelines addressing parenting or becoming parents among HIV-infected AYA in the United States. Research articles or practice guidelines on this topic were not identified. Given the paucity of information available on this topic, this article provides a framework for the development of appropriate interventions and guidelines for use in clinical and community-based settings. First, the social, economic, and sexual and reproductive health challenges facing HIV-infected AYA in the United States are summarized. Next, family planning considerations, including age-appropriate disclosure of HIV status to those who are perinatally infected, and contraceptive and preconception counseling are described. The impact of early childbearing on young parents is discussed and considerations are outlined during the preconception, antenatal, and postnatal periods with regard to antiretroviral medications and clinical care guidelines. The importance of transitioning AYA from pediatric or adolescent to adult-centered medical care is highlighted. Finally, a comprehensive approach is suggested that addresses not only medical needs but also emphasizes ways to mitigate the impact of social and economic factors on the health and well-being of these young parents and their children. JF - AIDS Patient Care and STDs AU - Hatfield-Timajchy, Kendra AU - Brown, Jennifer L AU - Haddad, Lisa B AU - Chakraborty, Rana AU - Kourtis, Athena P AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 315 EP - 323 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States VL - 30 IS - 7 SN - 1087-2914, 1087-2914 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859486690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Patient+Care+and+STDs&rft.atitle=Parenting+Among+Adolescents+and+Young+Adults+with+Human+Immunodeficiency+Virus+Infection+in+the+United+States%3A+Challenges%2C+Unmet+Needs%2C+and+Opportunities&rft.au=Hatfield-Timajchy%2C+Kendra%3BBrown%2C+Jennifer+L%3BHaddad%2C+Lisa+B%3BChakraborty%2C+Rana%3BKourtis%2C+Athena+P&rft.aulast=Hatfield-Timajchy&rft.aufirst=Kendra&rft.date=2016-07-01&rft.volume=30&rft.issue=7&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=AIDS+Patient+Care+and+STDs&rft.issn=10872914&rft_id=info:doi/10.1089%2Fapc.2016.0067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 65 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/apc.2016.0067 ER - TY - JOUR T1 - Age-Related Changes in Immunological Factors and Their Relevance in Allergic Disease Development During Childhood AN - 1837333991; PQ0003767457 AB - Purpose Allergic diseases are triggered by Th2-mediated immune reactions to allergens and orchestrated by various immunological factors, including immune cells and cytokines. Although many reports have suggested that childhood is the critical period in the onset of allergic diseases and aging leads to alter the susceptibility of an individual to allergic diseases, age-related changes in various immunological factors in healthy individuals as well as their difference between healthy and allergic children have not yet been established. Methods We investigated the ratio of Th1/Th2 cells and the levels of 22 allergy-related cytokines across all age groups in individuals who were classified as clinically non-atopic and healthy. We also examined their differences between healthy and allergic children to evaluate immunological changes induced by the development of allergic diseases during childhood. Results The Th1/Th2 ratio rose gradually during the growth period including childhood, reaching peak values in the twenties-thirties age group. Th1/Th2 ratios were significantly lower in allergic children than in healthy controls, whereas 14 of 22 cytokines were significantly higher in allergic children than in healthy controls. On the other hand, there were no differences in Th1/Th2 ratios and cytokines between healthy and allergic adolescents. Conclusions In this study, age-related changes in Th1/Th2 ratios were found in normal controls across all age groups, and decreases in Th1/Th2 ratio were observed with increasing of 14 cytokines in allergic children. The results of this study may be helpful as reference values for both monitoring immunological changes according to aging in healthy individuals and distinguishing between normal and allergic subjects in terms of immune cells and soluble factors. JF - Allergy, Asthma & Immunology Research AU - Chang, Woo-Sung AU - Kim, Eun-Jin AU - Lim, Yeon-Mi AU - Yoon, Dankyu AU - Son, Jo-Young AU - Park, Jung-Won AU - Hong, Soo-Jong AU - Cho, Sang-Heon AU - Lee, Joo-Shil AD - Division of Allergy and Chronic Respiratory Disease, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Disease Control and Prevention, Cheongju, Korea, jooshil@korea.kr Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 338 EP - 345 PB - Korean Academy of Asthma, Allergy and Clinical Immunology VL - 8 IS - 4 SN - 2092-7355, 2092-7355 KW - Toxicology Abstracts; Immunology Abstracts KW - Allergy KW - Th1/Th2 ratio KW - cytokine KW - chemokine KW - childhood KW - Age KW - Allergic diseases KW - Helper cells KW - Adolescence KW - Allergens KW - Aging KW - Lymphocytes T KW - Cytokines KW - Children KW - Critical period KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837333991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Allergy%2C+Asthma+%26+Immunology+Research&rft.atitle=Age-Related+Changes+in+Immunological+Factors+and+Their+Relevance+in+Allergic+Disease+Development+During+Childhood&rft.au=Chang%2C+Woo-Sung%3BKim%2C+Eun-Jin%3BLim%2C+Yeon-Mi%3BYoon%2C+Dankyu%3BSon%2C+Jo-Young%3BPark%2C+Jung-Won%3BHong%2C+Soo-Jong%3BCho%2C+Sang-Heon%3BLee%2C+Joo-Shil&rft.aulast=Chang&rft.aufirst=Woo-Sung&rft.date=2016-07-01&rft.volume=8&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Allergy%2C+Asthma+%26+Immunology+Research&rft.issn=20927355&rft_id=info:doi/10.4168%2Faair.2016.8.4.338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Allergic diseases; Allergens; Adolescence; Helper cells; Aging; Lymphocytes T; Cytokines; Critical period; Children DO - http://dx.doi.org/10.4168/aair.2016.8.4.338 ER - TY - JOUR T1 - Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective AN - 1811898282; PQ0003494092 JF - Clinical Microbiology Reviews AU - Kim, Lindsay AU - McGee, Lesley AU - Tomczyk, Sara AU - Beall, Bernard AD - << + $0, bbeall@cdc.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 525 EP - 552 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 29 IS - 3 SN - 0893-8512, 0893-8512 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus pneumoniae KW - Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811898282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Biological+and+Epidemiological+Features+of+Antibiotic-Resistant+Streptococcus+pneumoniae+in+Pre-+and+Post-Conjugate+Vaccine+Eras%3A+a+United+States+Perspective&rft.au=Kim%2C+Lindsay%3BMcGee%2C+Lesley%3BTomczyk%2C+Sara%3BBeall%2C+Bernard&rft.aulast=Kim&rft.aufirst=Lindsay&rft.date=2016-07-01&rft.volume=29&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/10.1128%2FCMR.00058-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 307 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Vaccines; Streptococcus pneumoniae DO - http://dx.doi.org/10.1128/CMR.00058-15 ER - TY - JOUR T1 - Limitations, depressive symptoms, and quality of life among a population-based sample of young adults with congenital heart defects AN - 1808711894; PQ0003484085 AB - Background Little population-based data exist on limitations and health-related quality of life (HRQoL) in adults with congenital heart defects (CHD). Methods We used 2004 to 2012 Medical Expenditure Panel Survey data to identify a population-based sample of young adults ages 18 to 40 years reporting health symptoms or healthcare encounters in the previous year. Comparing adults reporting CHD to others, we examined the prevalence of cognitive, physical, and activity limitations, depressive symptoms, and physical and mental HRQoL. We used chi square tests to examine differences in demographic characteristics, logistic regression to generate adjusted prevalence ratios (aPR), and linear regression to examine HRQoL. Multivariable associations were adjusted for sex, age, race/ethnicity, and smoking status. All analyses were conducted in SUDAAN using weights to account for clustering within sampling units and nonresponse. Results Fifty-nine adults reported CHD (weighted prevalence=0.1%; representing 700,000 U.S. adults from 2004 to 2012 or, on average, 80,000 per year) and 54,011 did not. No demographic characteristics differed significantly by CHD status except health insurance; 31.5% of adults with CHD, compared with 11.0% without, reported public insurance (p=0.01). Compared with their counterparts, adults reporting CHD had a higher prevalence of cognitive (aPR=2.7, 95% confidence interval (CI): 1.0, 7.2), physical (aPR=4.0, 95% CI: 1.9, 8.2), and activity limitations (aPR=4.8, 95% CI: 2.6, 9.1), and poorer physical HRQoL (p=0.004). No differences were observed in depressive symptoms and mental HRQoL by CHD status. Conclusion Physical health and cognitive abilities of adults with CHD were compromised compared with adults without CHD. Birth Defects Research (Part A) 106:580-586, 2016. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Farr, Sherry L AU - Oster, Matthew E AU - Simeone, Regina M AU - Gilboa, Suzanne M AU - Honein, Margaret A AD - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 580 EP - 586 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 7 SN - 1542-0752, 1542-0752 KW - Toxicology Abstracts KW - Demography KW - Heart KW - Smoking KW - Age KW - Depression KW - Data processing KW - Cognitive ability KW - Congenital defects KW - Sampling KW - Ethnic groups KW - Quality of life KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808711894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Limitations%2C+depressive+symptoms%2C+and+quality+of+life+among+a+population-based+sample+of+young+adults+with+congenital+heart+defects&rft.au=Farr%2C+Sherry+L%3BOster%2C+Matthew+E%3BSimeone%2C+Regina+M%3BGilboa%2C+Suzanne+M%3BHonein%2C+Margaret+A&rft.aulast=Farr&rft.aufirst=Sherry&rft.date=2016-07-01&rft.volume=106&rft.issue=7&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23498 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Heart; Demography; Smoking; Age; Data processing; Depression; Cognitive ability; Congenital defects; Sampling; Ethnic groups; Quality of life DO - http://dx.doi.org/10.1002/bdra.23498 ER - TY - JOUR T1 - Red Blood Cell Folate Insufficiency among nonpregnant Women of Childbearing age in Guatemala 2009 to 2010: Prevalence and predicted Neural Tube Defects risk AN - 1808706761; PQ0003484086 AB - Background The World Health Organization recently released recommendations stating that red blood cell (RBC) folate concentrations should be above 400 ng/L (906 nmol/L) for optimal prevention of folate-sensitive neural tube defects (NTDs). The objective of this study was to determine the distribution of folate insufficiency (FI) (<906 nmol/L) and potential risk of NTDs based on RBC folate concentrations among nonpregnant women of child-bearing age in Guatemala. Methods A national and regional multistage cluster probability survey was completed during 2009 to 2010 among Guatemalan women of child-bearing age 15 to 49 years of age. Demographic and health information and blood samples for RBC folate analyses were collected from 1473 women. Prevalence rate ratios of FI and predicted NTD prevalence were estimated based on RBC folate concentrations comparing subpopulations of interest. Results National FI prevalence was 47.2% [95% confidence interval, 43.3-51.1] and showed wide variation by region (18-81%). In all regions, FI prevalence was higher among indigenous (27-89%) than among nonindigenous populations (16-44%). National NTD risk based on RBC folate concentrations was estimated to be 14 per 10,000 live births (95% uncertainty interval, 11.1-18.6) and showed wide regional variation (from 11 NTDS in the Metropolitan region to 26 NTDs per 10,000 live births in the Norte region). Conclusion FI remains a common problem in populations with limited access to fortified products, specifically rural, low income, and indigenous populations. However, among subpopulations that are most likely to have fortified food, the prevalence of FI is similar to countries with well-established fortification programs. Birth Defects Research (Part A) 106:587-595, 2016. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Rosenthal, Jorge AU - Reeve, Mary-Elizabeth AU - Ramirez, Nicte AU - Crider, Krista S AU - Sniezek, Joe AU - Vellozzi, Claudia AU - Devine, Owen AU - Lopez-Pazos, Eunice AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 587 EP - 595 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 7 SN - 1542-0752, 1542-0752 KW - Toxicology Abstracts KW - Demography KW - Age KW - Food KW - Erythrocytes KW - Congenital defects KW - Folic acid KW - Neural tube defects KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808706761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Red+Blood+Cell+Folate+Insufficiency+among+nonpregnant+Women+of+Childbearing+age+in+Guatemala+2009+to+2010%3A+Prevalence+and+predicted+Neural+Tube+Defects+risk&rft.au=Rosenthal%2C+Jorge%3BReeve%2C+Mary-Elizabeth%3BRamirez%2C+Nicte%3BCrider%2C+Krista+S%3BSniezek%2C+Joe%3BVellozzi%2C+Claudia%3BDevine%2C+Owen%3BLopez-Pazos%2C+Eunice&rft.aulast=Rosenthal&rft.aufirst=Jorge&rft.date=2016-07-01&rft.volume=106&rft.issue=7&rft.spage=587&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23499 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Demography; Age; Food; Erythrocytes; Congenital defects; Folic acid; Neural tube defects DO - http://dx.doi.org/10.1002/bdra.23499 ER - TY - JOUR T1 - C-reactive protein increases with gestational age during pregnancy among Chinese women AN - 1808697928; PQ0003483914 AB - Objective To examine the concentration of C-reactive protein (CRP) in relation to gestational weeks during pregnancy among Chinese women. Methods From a randomized control trial of prenatal supplementation with folic acid, iron-folic acid, and multiple micronutrients in China, we examined 834 pregnant women with CRP measured initially between 5 and 20 weeks and at follow-up between 28 and 32 weeks gestation. We calculated and plotted CRP geometric means by gestational weeks. The same analysis was repeated for women who had normal pregnancies (624 women) by excluding women with stillbirth, preterm, small for gestational age, body mass index 30 kg/m super(2) at enrollment, and hypertension or anemia during pregnancy. Results We observed a significant positive trend between log-transformed CRP and gestational age from 5 to 20 weeks and from 28 to 32 weeks both in the full sample and in the subset of women who had normal pregnancies. CRP geometric mean was 0.81 mg/l at 5-7 weeks of gestation, 2.85 mg/l at 19-20 weeks of gestation, and 3.89 mg/l at 32 weeks of gestation. A similar increasing trend in the CRP median or percentage of elevated CRP were also observed. Conclusion We concluded that CRP increased with gestational age among healthy Chinese women who delivered healthy infants. Am. J. Hum. Biol. 28:574-579, 2016. JF - American Journal of Human Biology AU - Mei, Zuguo AU - Li, Hongtian AU - Serdula, Mary K AU - Flores-Ayala, RAFAEL C AU - Wang, Linlin AU - Liu, Jian-Meng AU - Grummer-Strawn, Laurence M AD - Division of Nutrition, Physical Activity and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 574 EP - 579 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 4 SN - 1042-0533, 1042-0533 KW - Physical Education Index; Environment Abstracts KW - Measurement KW - Age KW - Prenatal experience KW - Body mass KW - Women KW - Anemia KW - Health KW - Pregnancy KW - Low-birth-weight KW - Objectives KW - Analysis KW - Proteins KW - China, People's Rep. KW - Females KW - Micronutrients KW - Folic acid KW - Trends KW - Infants KW - Hypertension KW - ENA 08:International KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808697928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Biology&rft.atitle=C-reactive+protein+increases+with+gestational+age+during+pregnancy+among+Chinese+women&rft.au=Mei%2C+Zuguo%3BLi%2C+Hongtian%3BSerdula%2C+Mary+K%3BFlores-Ayala%2C+RAFAEL+C%3BWang%2C+Linlin%3BLiu%2C+Jian-Meng%3BGrummer-Strawn%2C+Laurence+M&rft.aulast=Mei&rft.aufirst=Zuguo&rft.date=2016-07-01&rft.volume=28&rft.issue=4&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Biology&rft.issn=10420533&rft_id=info:doi/10.1002%2Fajhb.22837 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Measurement; Analysis; Objectives; Women; Proteins; Health; Trends; Hypertension; Pregnancy; Age; Prenatal experience; Low-birth-weight; Body mass; Anemia; Micronutrients; Females; Folic acid; Infants; China, People's Rep. DO - http://dx.doi.org/10.1002/ajhb.22837 ER - TY - JOUR T1 - Antibody Levels and Protection After Hepatitis B Vaccine: Results of a 30-Year Follow-up Study and Response to a Booster Dose AN - 1808685610; PQ0003326204 AB - Background.The duration of protection in children and adults resulting from hepatitis B vaccination is unknown. In 1981, we immunized a cohort of 1578 Alaska Native adults and children from 15 Alaska communities aged > or =6 months using 3 doses of plasma-derived hepatitis B vaccine. Methods.Persons were tested for antibody to hepatitis B surface antigen (anti-HBs) levels 30 years after receiving the primary series. Those with levels or =10 mIU/mL. Among participants with anti-HBs levels or =10 mIU/mL at 30 days. Initial anti-HBs level after the primary series was correlated with higher anti-HBs levels at 30 years. Conclusions.Based on anti-HBs level > or =10 mIU/mL at 30 years and an 88% booster dose response, we estimate that > or =90% of participants had evidence of protection 30 years later. Booster doses are not needed. JF - Journal of Infectious Diseases AU - Bruce, Michael G AU - Bruden, Dana AU - Hurlburt, Debby AU - Zanis, Carolyn AU - Thompson, Gail AU - Rea, Lisa AU - Toomey, Michele AU - Townshend-Bulson, Lisa AU - Rudolph, Karen AU - Bulkow, Lisa AU - Spradling, Philip R AU - Baum, Richard AU - Hennessy, Thomas AU - McMahon, Brian J AD - Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, zwa8@cdc.gov Y1 - 2016/07/01/ PY - 2016 DA - 2016 Jul 01 SP - 16 EP - 22 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 214 IS - 1 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - hepatitis B KW - immunogenicity KW - Alaska Native KW - plasma-derived vaccine KW - Alaska KW - US KW - cohort KW - 30 years KW - antibody KW - anti-HBs KW - Antibodies KW - Hepatitis B virus KW - Infectious diseases KW - INE, USA, Alaska KW - Hepatitis B surface antigen KW - Vaccines KW - Children KW - Vaccination KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808685610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Antibody+Levels+and+Protection+After+Hepatitis+B+Vaccine%3A+Results+of+a+30-Year+Follow-up+Study+and+Response+to+a+Booster+Dose&rft.au=Bruce%2C+Michael+G%3BBruden%2C+Dana%3BHurlburt%2C+Debby%3BZanis%2C+Carolyn%3BThompson%2C+Gail%3BRea%2C+Lisa%3BToomey%2C+Michele%3BTownshend-Bulson%2C+Lisa%3BRudolph%2C+Karen%3BBulkow%2C+Lisa%3BSpradling%2C+Philip+R%3BBaum%2C+Richard%3BHennessy%2C+Thomas%3BMcMahon%2C+Brian+J&rft.aulast=Bruce&rft.aufirst=Michael&rft.date=2016-07-01&rft.volume=214&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Hepatitis B surface antigen; Vaccines; Children; Vaccination; Infectious diseases; Hepatitis B virus; INE, USA, Alaska DO - http://dx.doi.org/10.1093/infdis/jiv748 ER - TY - JOUR T1 - Tetanus Immunity among Women Aged 15 to 39 Years in Cambodia: a National Population-Based Serosurvey, 2012 AN - 1808645754; PQ0003406198 AB - To monitor progress toward maternal and neonatal tetanus elimination (MNTE) in Cambodia, we conducted a nationwide serosurvey of tetanus immunity in 2012. Multistage cluster sampling was used to select 2,154 women aged 15 to 39 years. Tetanus toxoid antibodies in serum samples were measured by gold-standard double-antigen enzyme-linked immunosorbent assay (DAE) and a novel multiplex bead assay (MBA). Antibody concentrations of greater than or equal to 0.01 IU/ml by DAE or the equivalent for MBA were considered seroprotective. Estimated tetanus seroprotection was 88% (95% confidence interval [CI], 86 to 89%); 64% (95% CI, 61 to 67%) of women had antibody levels of greater than or equal to 1.0 IU/ml. Seroprotection was significantly lower (P < 0.001) among women aged 15 to 19 years (63%) and 20 to 24 years (87%) than among those aged greater than or equal to 25 years (96%), among nulliparous women than among parous women (71 versus 97%), and among those living in the western region than among those living in other regions (82 versus 89%). The MBA showed high sensitivity (99% [95% CI, 98 to 99%]) and specificity (92% [95% CI, 88 to 95%]) compared with DAE. Findings were compatible with MNTE in Cambodia ( greater than or equal to 80% protection). Tetanus immunity gaps should be addressed through strengthened routine immunization and targeted vaccination campaigns. Incorporating tetanus testing in national serosurveys using MBAs, which can measure immunity to multiple pathogens simultaneously, may be beneficial for monitoring MNTE. JF - Clinical and Vaccine Immunology AU - Scobie, Heather M AU - Mao, Bunsoth AU - Buth, Sokhal AU - Wannemuehler, Kathleen A AU - Soerensen, Charlotte AU - Kannarath, Chheng AU - Jenks, M Harley AU - Moss, Delynn M AU - Priest, Jeffrey W AU - Soeung, Sann Chan AD - << + $0, hscobie@cdc.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 546 EP - 554 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 23 IS - 7 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Antibodies KW - Enzyme-linked immunosorbent assay KW - Immunity KW - Neonates KW - Pathogens KW - Sampling KW - Vaccines KW - Tetanus KW - Vaccination KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808645754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Tetanus+Immunity+among+Women+Aged+15+to+39+Years+in+Cambodia%3A+a+National+Population-Based+Serosurvey%2C+2012&rft.au=Scobie%2C+Heather+M%3BMao%2C+Bunsoth%3BButh%2C+Sokhal%3BWannemuehler%2C+Kathleen+A%3BSoerensen%2C+Charlotte%3BKannarath%2C+Chheng%3BJenks%2C+M+Harley%3BMoss%2C+Delynn+M%3BPriest%2C+Jeffrey+W%3BSoeung%2C+Sann+Chan&rft.aulast=Scobie&rft.aufirst=Heather&rft.date=2016-07-01&rft.volume=23&rft.issue=7&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00052-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 42 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Vaccines; Sampling; Pathogens; Neonates; Immunity; Tetanus; Vaccination DO - http://dx.doi.org/10.1128/CVI.00052-16 ER - TY - JOUR T1 - Zika Virus Disease in Travelers Returning to the United States, 2010-2014 AN - 1808636917; PQ0003465327 AB - Zika virus is an emerging mosquito-borne flavivirus that typically causes a mild febrile illness with rash, arthralgia, or conjunctivitis. Zika virus has recently caused large outbreaks of disease in southeast Asia, Pacific Ocean Islands, and the Americas. We identified all positive Zika virus test results performed at U.S. Centers for Disease Control and Prevention from 2010 to 2014. For persons with test results indicating a recent infection with Zika virus, we collected information on demographics, travel history, and clinical features. Eleven Zika virus disease cases were identified among travelers returning to the United States. The median age of cases was 50 years (range: 29-74 years) and six (55%) were male. Nine (82%) cases had their illness onset from January to April. All cases reported a travel history to islands in the Pacific Ocean during the days preceding illness onset, and all cases were potentially viremic while in the United States. Public health prevention messages about decreasing mosquito exposure, preventing sexual exposure, and preventing infection in pregnant women should be targeted to individuals traveling to or living in areas with Zika virus activity. Health-care providers and public health officials should be educated about the recognition, diagnosis, and prevention of Zika virus disease. JF - American Journal of Tropical Medicine and Hygiene AU - Hennessey, Morgan J AU - Fischer, Marc AU - Panella, Amanda J AU - Kosoy, Olga I AU - Laven, Janeen J AU - Lanciotti, Robert S AU - Staples, J Erin AD - Arboviral Diseases Branch, Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado, estaples@cdc.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 212 EP - 215 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 95 IS - 1 SN - 0002-9637, 0002-9637 KW - Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Travel KW - Historical account KW - Age KW - Zika virus KW - Viruses KW - Disease control KW - Infection KW - Flavivirus KW - Public health KW - Demography KW - Exanthema KW - Islands KW - I, Pacific KW - Arthralgia KW - Biological surveys KW - Conjunctivitis KW - Pregnancy KW - I, Central Pacific, Pacific Ocean Is. KW - Prevention KW - Oceans KW - Outbreaks KW - ISEW, Southeast Asia KW - Hygiene KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - H 12000:Epidemiology and Public Health KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808636917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Zika+Virus+Disease+in+Travelers+Returning+to+the+United+States%2C+2010-2014&rft.au=Hennessey%2C+Morgan+J%3BFischer%2C+Marc%3BPanella%2C+Amanda+J%3BKosoy%2C+Olga+I%3BLaven%2C+Janeen+J%3BLanciotti%2C+Robert+S%3BStaples%2C+J+Erin&rft.aulast=Hennessey&rft.aufirst=Morgan&rft.date=2016-07-01&rft.volume=95&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.16-0049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Disease control; Hygiene; Public health; Demography; Travel; Exanthema; Age; Islands; Oceans; Conjunctivitis; Infection; Arthralgia; Pregnancy; Historical account; Viruses; Prevention; Outbreaks; Zika virus; Flavivirus; I, Central Pacific, Pacific Ocean Is.; I, Pacific; ISEW, Southeast Asia DO - http://dx.doi.org/10.4269/ajtmh.16-0049 ER - TY - JOUR T1 - Rapid Antimicrobial Susceptibility Testing of Bacillus anthracis, Yersinia pestis, and Burkholderia pseudomallei by Use of Laser Light Scattering Technology AN - 1846404536; PQ0003246979 AB - Rapid methods to determine antimicrobial susceptibility would assist in the timely distribution of effective treatment or postexposure prophylaxis in the aftermath of the release of bacterial biothreat agents such as Bacillus anthracis, Yersinia pestis, or Burkholderia pseudomallei. Conventional susceptibility tests require 16 to 48 h of incubation, depending on the bacterial species. We evaluated a method that is based on laser light scattering technology that measures cell density in real time. We determined that it has the ability to rapidly differentiate between growth (resistant) and no growth (susceptible) of several bacterial threat agents in the presence of clinically relevant antimicrobials. Results were available in 10 h of incubation. Use of laser scattering technology decreased the time required to determine antimicrobial susceptibility by 50% to 75% for B. anthracis, Y. pestis, and B. pseudomallei compared to conventional methods. JF - Journal of Clinical Microbiology AU - Bugrysheva, Julia V AU - Lascols, Christine AU - Sue, David AU - Weigel, Linda M Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1462 EP - 1471 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 54 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846404536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Rapid+Antimicrobial+Susceptibility+Testing+of+Bacillus+anthracis%2C+Yersinia+pestis%2C+and+Burkholderia+pseudomallei+by+Use+of+Laser+Light+Scattering+Technology&rft.au=Bugrysheva%2C+Julia+V%3BLascols%2C+Christine%3BSue%2C+David%3BWeigel%2C+Linda+M&rft.aulast=Chiantore&rft.aufirst=Mariachiara&rft.date=2006-05-01&rft.volume=29&rft.issue=6&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Polar+Biology&rft.issn=07224060&rft_id=info:doi/10.1007%2Fs00300-005-0077-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 32 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1128/JCM.03251-15 ER - TY - JOUR T1 - Infant and maternal risk factors related to necrotising enterocolitis-associated infant death in the United States AN - 1811897394; PQ0003082159 AB - Aim To evaluate necrotising enterocolitis (NEC)-associated infant death and identify risk factors related to NEC infant death in the United States. Methods The United States Period Linked Birth/Infant Death data for 2010-2013 were utilised to determine risk factors associated with NEC infant death. Infant mortality rates (IMRs) were calculated and a retrospective matched case-control analysis was performed. An infant case was defined as having the International Classification of Diseases, Tenth Revision code for NEC listed on the death record. Controls were matched on birthweight and randomly selected. Conditional multivariable logistic regression models stratified by birthweight were conducted to determine risk factors for NEC infant death. Results The average annual NEC IMR was 12.5 deaths per 100 000 live births and was higher among very low birthweight (VLBW) compared to normal birthweight infants and among black compared to white infants. For VLBW infants, the multivariable analysis identified male sex, five-minute Apgar score of less than 7, and white infants born to a mother who is less than or equal to 19 years of age to be related with NEC-associated infant death. Conclusion Paediatricians should be aware of the factors related to NEC-associated infant death to reduce the number of infants at greatest risk for NEC and focus on racial disparities. JF - Acta Paediatrica AU - Seeman, Sara M AU - Mehal, Jason M AU - Haberling, Dana L AU - Holman, Robert C AU - Stoll, Barbara J AD - Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - e240 EP - e246 PB - Wiley-Blackwell Publishing, 9600 Garsington Rd Oxford United Kingdom VL - 105 IS - 6 SN - 0803-5253, 0803-5253 KW - Physical Education Index KW - Death KW - Classification KW - Blacks KW - Risk factors KW - Analysis KW - Diseases KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811897394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Paediatrica&rft.atitle=Infant+and+maternal+risk+factors+related+to+necrotising+enterocolitis-associated+infant+death+in+the+United+States&rft.au=Seeman%2C+Sara+M%3BMehal%2C+Jason+M%3BHaberling%2C+Dana+L%3BHolman%2C+Robert+C%3BStoll%2C+Barbara+J&rft.aulast=Seeman&rft.aufirst=Sara&rft.date=2016-06-01&rft.volume=105&rft.issue=6&rft.spage=e240&rft.isbn=&rft.btitle=&rft.title=Acta+Paediatrica&rft.issn=08035253&rft_id=info:doi/10.1111%2Fapa.13390 LA - English DB - Physical Education Index N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Death; Classification; Blacks; Analysis; Risk factors; Diseases; Sex DO - http://dx.doi.org/10.1111/apa.13390 ER - TY - JOUR T1 - Advanced Molecular Detection of Malarone Resistance AN - 1808723406; PQ0003229746 AB - The rapid emergence of drug-resistant malaria parasites during the course of an infection remains a major challenge for providing accurate treatment guidelines. This is particularly important in cases of malaria treatment failure. Using a previously well-characterized case of malaria treatment failure, we show the utility of using next-generation sequencing for early detection of the rise and selection of a previously reported atovaquone-proguanil (malarone) drug resistance-associated mutation. JF - Antimicrobial Agents & Chemotherapy AU - Talundzic, Eldin AU - Plucinski, Mateusz M AU - Biliya, Shweta AU - Silva-Flannery, Luciana M AU - Arguin, Paul M AU - Halsey, Eric S AU - Barnwell, John W AU - Vannberg, Fredrik AU - Udhayakumar, Venkatachalam AD - << + $0, etalundzic@cdc.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3821 EP - 3823 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 6 SN - 0066-4804, 0066-4804 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Parasites KW - Human diseases KW - Mutations KW - Drug resistance KW - Disease control KW - Malaria KW - Infection KW - Public health KW - Mutation KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808723406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Advanced+Molecular+Detection+of+Malarone+Resistance&rft.au=Talundzic%2C+Eldin%3BPlucinski%2C+Mateusz+M%3BBiliya%2C+Shweta%3BSilva-Flannery%2C+Luciana+M%3BArguin%2C+Paul+M%3BHalsey%2C+Eric+S%3BBarnwell%2C+John+W%3BVannberg%2C+Fredrik%3BUdhayakumar%2C+Venkatachalam&rft.aulast=Talundzic&rft.aufirst=Eldin&rft.date=2016-06-01&rft.volume=60&rft.issue=6&rft.spage=3821&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00171-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Mutations; Disease control; Malaria; Drugs; Public health; Drug resistance; Infection; Mutation DO - http://dx.doi.org/10.1128/AAC.00171-16 ER - TY - JOUR T1 - Persistence of Influenza A (H1N1) Virus on Stainless Steel Surfaces AN - 1808721756; PQ0003229838 AB - As annual influenza epidemics continue to cause significant morbidity and economic burden, an understanding of viral persistence and transmission is critical for public health officials and health care workers to better protect patients and their family members from infection. The infectivity and persistence of two influenza A (H1N1) virus strains (A/New Caledonia/20/1999 and A/Brisbane/59/2007) on stainless steel (SS) surfaces were evaluated using three different surface matrices (2% fetal bovine serum, 5 mg/ml mucin, and viral medium) under various absolute humidity conditions (4.1 105 mPa, 6.5 105 mPa, 7.1 105 mPa, 11.4 105 mPa, 11.2 105 mPa, and 17.9 105 mPa) for up to 7 days. Influenza A virus was deposited onto SS coupons (7.07 cm2) and recovered by agitation and sonication in viral medium. Viral persistence was quantified using a tissue culture-based enzyme-linked immunosorbent assay (ELISA) to determine the median (50%) tissue culture infective dose (TCID50) of infectious virus per coupon. Overall, both strains of influenza A virus remained infectious on SS coupons, with an approximate 2 log10 loss over 7 days. Factors that influenced viral persistence included absolute humidity, strain-absolute humidity interaction, and time (P less than or equal to 0.01). Further studies on the transfer of influenza A virus from fomites by hand and the impact of inanimate surface contamination on transmission should be performed, as this study demonstrates prolonged persistence on nonporous surfaces. IMPORTANCE This study tested the ability of two influenza A (H1N1) virus strains to persist and remain infectious on stainless steel surfaces under various environmental conditions. It demonstrated that influenza A (H1N1) viruses can persist and remain infectious on stainless steel surfaces for 7 days. Additional studies should be conducted to assess the role played by contaminated surfaces in the transmission of influenza A virus. JF - Antimicrobial Agents & Chemotherapy AU - Perry, K A AU - Coulliette, A D AU - Rose, L J AU - Shams, A M AU - Edwards, J R AU - Noble-Wang, J A AD - << + $0, KPerry@cdc.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3239 EP - 3245 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 11 SN - 0099-2240, 0099-2240 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Contamination KW - Influenza A KW - Viruses KW - Absolute humidity KW - Infection KW - Medical personnel KW - Morbidity KW - Public health KW - Mucins KW - Influenza KW - Influenza A virus KW - Economics KW - mucin KW - Steel KW - Enzyme-linked immunosorbent assay KW - Epidemics KW - Hand KW - Humidity KW - Tissue culture KW - Sonication KW - Fomites KW - Infectivity KW - ISEW, Pacific, New Caledonia KW - Environmental conditions KW - Immunoassays KW - Australia, Queensland, Brisbane KW - stainless steel KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808721756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Persistence+of+Influenza+A+%28H1N1%29+Virus+on+Stainless+Steel+Surfaces&rft.au=Perry%2C+K+A%3BCoulliette%2C+A+D%3BRose%2C+L+J%3BShams%2C+A+M%3BEdwards%2C+J+R%3BNoble-Wang%2C+J+A&rft.aulast=Perry&rft.aufirst=K&rft.date=2016-06-01&rft.volume=82&rft.issue=11&rft.spage=3239&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.04046-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 39 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Epidemics; Contamination; Influenza A; Humidity; Hand; Tissue culture; Infection; Morbidity; Medical personnel; Public health; Fomites; Sonication; Infectivity; Economics; mucin; Environmental conditions; stainless steel; Viruses; Absolute humidity; Influenza; Mucins; Steel; Immunoassays; Influenza A virus; ISEW, Pacific, New Caledonia; Australia, Queensland, Brisbane DO - http://dx.doi.org/10.1128/AEM.04046-15 ER - TY - JOUR T1 - Genomic Resolution of Outbreak-Associated Legionella pneumophila Serogroup 1 Isolates from New York State AN - 1808713594; PQ0003229849 AB - A total of 30 Legionella pneumophila serogroup 1 isolates representing 10 separate legionellosis laboratory investigations ("outbreaks") that occurred in New York State between 2004 and 2012 were selected for evaluation of whole-genome sequencing (WGS) approaches for molecular subtyping of this organism. Clinical and environmental isolates were available for each outbreak and were initially examined by pulsed-field gel electrophoresis (PFGE). Sequence-based typing alleles were extracted from WGS data yielding complete sequence types (ST) for isolates representing 8 out of the 10 outbreaks evaluated in this study. Isolates from separate outbreaks sharing the same ST also contained the fewest differences in core genome single nucleotide polymorphisms (SNPs) and the greatest proportion of identical allele sequences in a whole-genome multilocus sequence typing (wgMLST) scheme. Both core SNP and wgMLST analyses distinguished isolates from separate outbreaks, including those from two outbreaks sharing indistinguishable PFGE profiles. Isolates from a hospital-associated outbreak spanning multiple years shared indistinguishable PFGE profiles but displayed differences in their genome sequences, suggesting the presence of multiple environmental sources. Finally, the rtx gene demonstrated differences in the repeat region sequence among ST1 isolates from different outbreaks, suggesting that variation in this gene may be useful for targeted molecular subtyping approaches for L. pneumophila. This study demonstrates the utility of various genome sequence analysis approaches for L. pneumophila for environmental source attribution studies while furthering the understanding of Legionella ecology. IMPORTANCE We demonstrate that whole-genome sequencing helps to improve resolution of Legionella pneumophila isolated during laboratory investigations of legionellosis compared to traditional subtyping methods. These data can be important in confirming the environmental sources of legionellosis outbreaks. Moreover, we evaluated various methods to analyze genome sequence data to help resolve outbreak-related isolates. JF - Antimicrobial Agents & Chemotherapy AU - Raphael, Brian H AU - Baker, Deborah J AU - Nazarian, Elizabeth AU - Lapierre, Pascal AU - Bopp, Dianna AU - Kozak-Muiznieks, Natalia A AU - Morrison, Shatavia S AU - Lucas, Claressa E AU - Mercante, Jeffrey W AU - Musser, Kimberlee A AD - << + $0, jwinchell@cdc.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3582 EP - 3590 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 12 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Legionella pneumophila KW - Data processing KW - Typing KW - Single-nucleotide polymorphism KW - Nucleotide sequence KW - Pulsed-field gel electrophoresis KW - genomics KW - multilocus sequence typing KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808713594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Genomic+Resolution+of+Outbreak-Associated+Legionella+pneumophila+Serogroup+1+Isolates+from+New+York+State&rft.au=Raphael%2C+Brian+H%3BBaker%2C+Deborah+J%3BNazarian%2C+Elizabeth%3BLapierre%2C+Pascal%3BBopp%2C+Dianna%3BKozak-Muiznieks%2C+Natalia+A%3BMorrison%2C+Shatavia+S%3BLucas%2C+Claressa+E%3BMercante%2C+Jeffrey+W%3BMusser%2C+Kimberlee+A&rft.aulast=Raphael&rft.aufirst=Brian&rft.date=2016-06-01&rft.volume=82&rft.issue=12&rft.spage=3582&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 28 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Genomes; Typing; Data processing; Single-nucleotide polymorphism; Nucleotide sequence; Pulsed-field gel electrophoresis; genomics; multilocus sequence typing; Legionella pneumophila DO - http://dx.doi.org/10.1128/AEM.00362-16 ER - TY - JOUR T1 - Improving Capture of Vaccine History: Case Study from an Evaluation of 10-Valent Pneumococcal Conjugate Vaccine Introduction in Kenya AN - 1808639784; PQ0003290542 AB - With the accelerated introduction of new vaccines in low-income settings, understanding immunization program performance is critical. We sought to improve immunization history acquisition from Ministry of Health vaccination cards during a vaccine impact study of 10-valent pneumococcal conjugate vaccine on pneumococcal carriage among young children in Kenya in 2012 and 2013. We captured immunization history in a low proportion of study participants in 2012 using vaccination cards. To overcome this challenge, we implemented a household-based reminder system in 2013 using community health workers (CHWs), and increased the retrieval of vaccine cards from 62% in 2012 to 89% in 2013 (P< 0.001). The home-based reminder system using CHWs is an example of an approach that improved immunization history data quality in a resource-poor setting. JF - American Journal of Tropical Medicine and Hygiene AU - Harris, Aaron M AU - Aol, George AU - Ouma, Dominic AU - Bigogo, Godfrey AU - Montgomery, Joel M AU - Whitney, Cynthia G AU - Breiman, Robert F AU - Kim, Lindsay AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, ieo9@cdc.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1400 EP - 1402 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 94 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Historical account KW - Data processing KW - Disease control KW - Socioeconomics KW - Children KW - Vaccination KW - Immunization KW - Workers KW - Streptococcus pneumoniae KW - Kenya KW - Case studies KW - Reminder KW - Vaccines KW - Hygiene KW - K 03400:Human Diseases KW - Q5 08504:Effects on organisms KW - J 02350:Immunology KW - Q1 08604:Stock assessment and management KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808639784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Improving+Capture+of+Vaccine+History%3A+Case+Study+from+an+Evaluation+of+10-Valent+Pneumococcal+Conjugate+Vaccine+Introduction+in+Kenya&rft.au=Harris%2C+Aaron+M%3BAol%2C+George%3BOuma%2C+Dominic%3BBigogo%2C+Godfrey%3BMontgomery%2C+Joel+M%3BWhitney%2C+Cynthia+G%3BBreiman%2C+Robert+F%3BKim%2C+Lindsay&rft.aulast=Harris&rft.aufirst=Aaron&rft.date=2016-06-01&rft.volume=94&rft.issue=6&rft.spage=1400&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0783 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disease control; Vaccines; Hygiene; Vaccination; Immunization; Workers; Data processing; Reminder; Children; Historical account; Case studies; Socioeconomics; Streptococcus pneumoniae; Kenya DO - http://dx.doi.org/10.4269/ajtmh.15-0783 ER - TY - JOUR T1 - Chikungunya and Dengue Virus Infections Among United States Community Service Volunteers Returning from the Dominican Republic, 2014 AN - 1808615664; PQ0003290532 AB - Chikungunya spread throughout the Dominican Republic (DR) after the first identified laboratory-confirmed cases were reported in April 2014. In June 2014, a U.S.-based service organization operating in the DR reported chikungunya-like illnesses among several staff. We assessed the incidence of chikungunya virus (CHIKV) and dengue virus (DENV) infection and illnesses and evaluated adherence to mosquito avoidance measures among volunteers/staff deployed in the DR who returned to the United States during July-August 2014. Investigation participants completed a questionnaire that collected information on demographics, medical history, self-reported illnesses, and mosquito exposures and avoidance behaviors and provided serum for CHIKV and DENV diagnostic testing by reverse transcription polymerase chain reaction and IgM enzyme-linked immunosorbent assay. Of 102 participants, 42 (41%) had evidence of recent CHIKV infection and two (2%) had evidence of recent DENV infection. Of the 41 participants with evidence of recent CHIKV infection only, 39 (95%) reported fever, 37 (90%) reported rash, and 37 (90%) reported joint pain during their assignment. All attended the organization's health trainings, and 89 (87%) sought a pretravel health consultation. Most (~95%) used insect repellent; however, only 30% applied it multiple times daily and < 5% stayed in housing with window/door screens. In sum, CHIKV infections were common among these volunteers during the 2014 chikungunya epidemic in the DR. Despite high levels of preparation, reported adherence to mosquito avoidance measures were inconsistent. Clinicians should discuss chikungunya with travelers visiting areas with ongoing CHIKV outbreaks and should consider chikungunya when diagnosing febrile illnesses in travelers returning from affected areas. JF - American Journal of Tropical Medicine and Hygiene AU - Millman, Alexander J AU - Esposito, Douglas H AU - Biggs, Holly M AU - Decenteceo, Michelle AU - Klevos, Andrew AU - Hunsperger, Elizabeth AU - Munoz-Jordan, Jorge AU - Kosoy, Olga I AU - McPherson, Heidi AU - Sullivan, Carmen AD - Centers for Disease Control and Prevention, Atlanta, Georgia, irm6@cdc.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1336 EP - 1341 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 94 IS - 6 SN - 0002-9637, 0002-9637 KW - Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Dengue virus KW - Historical account KW - Human diseases KW - Housing KW - Nucleotide sequence KW - Viruses KW - Avoidance reactions KW - Pain KW - Infection KW - Reverse transcription KW - Public health KW - Demography KW - Fever KW - Exanthema KW - Repellents KW - Polymerase chain reaction KW - Biological surveys KW - Inventories KW - Enzyme-linked immunosorbent assay KW - Chikungunya virus KW - Epidemics KW - Training KW - Avoidance behavior KW - Transcription KW - Pest control KW - Pest outbreaks KW - Insects KW - Joints KW - USA KW - Dominican Republic KW - Outbreaks KW - Hygiene KW - Immunoassays KW - Immunoglobulin M KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 0500:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808615664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Chikungunya+and+Dengue+Virus+Infections+Among+United+States+Community+Service+Volunteers+Returning+from+the+Dominican+Republic%2C+2014&rft.au=Millman%2C+Alexander+J%3BEsposito%2C+Douglas+H%3BBiggs%2C+Holly+M%3BDecenteceo%2C+Michelle%3BKlevos%2C+Andrew%3BHunsperger%2C+Elizabeth%3BMunoz-Jordan%2C+Jorge%3BKosoy%2C+Olga+I%3BMcPherson%2C+Heidi%3BSullivan%2C+Carmen&rft.aulast=Millman&rft.aufirst=Alexander&rft.date=2016-06-01&rft.volume=94&rft.issue=6&rft.spage=1336&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0815 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Epidemics; Nucleotide sequence; Transcription; Avoidance reactions; Pest control; Hygiene; Public health; Inventories; Enzyme-linked immunosorbent assay; Housing; Avoidance behavior; Pain; Infection; Pest outbreaks; Reverse transcription; Joints; Fever; Demography; Exanthema; Repellents; Polymerase chain reaction; Immunoglobulin M; Historical account; Training; Viruses; Outbreaks; Immunoassays; Insects; Dengue virus; Chikungunya virus; USA; Dominican Republic DO - http://dx.doi.org/10.4269/ajtmh.15-0815 ER - TY - JOUR T1 - Molecular Characterizations of Surface Proteins Hemagglutinin and Neuraminidase from Recent H5Nx Avian Influenza Viruses AN - 1808612563; PQ0003247020 AB - During 2014, a subclade 2.3.4.4 highly pathogenic avian influenza (HPAI) A(H5N8) virus caused poultry outbreaks around the world. In late 2014/early 2015, the virus was detected in wild birds in Canada and the United States, and these viruses also gave rise to reassortant progeny, composed of viral RNA segments (vRNAs) from both Eurasian and North American lineages. In particular, viruses were found with N1, N2, and N8 neuraminidase vRNAs, and these are collectively referred to as H5Nx viruses. In the United States, more than 48 million domestic birds have been affected. Here we present a detailed structural and biochemical analysis of the surface antigens of H5N1, H5N2, and H5N8 viruses in addition to those of a recent human H5N6 virus. Our results with recombinant hemagglutinin reveal that these viruses have a strict avian receptor binding preference, while recombinantly expressed neuraminidases are sensitive to FDA-approved and investigational antivirals. Although H5Nx viruses currently pose a low risk to humans, it is important to maintain surveillance of these circulating viruses and to continually assess future changes that may increase their pandemic potential. IMPORTANCE The H5Nx viruses emerging in North America, Europe, and Asia pose a great public health concern. Here we report a molecular and structural study of the major surface proteins of several H5Nx influenza viruses. Our results improve the understanding of these new viruses and provide important information on their receptor preferences and susceptibilities to antivirals, which are central to pandemic risk assessment. JF - Journal of Virology AU - Yang, Hua AU - Carney, Paul J AU - Mishin, Vasiliy P AU - Guo, Zhu AU - Chang, Jessie C AU - Wentworth, David E AU - Gubareva, Larisa V AU - Stevens, James Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 5770 EP - 5784 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 90 IS - 12 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - Poultry KW - Hemagglutinins KW - Viruses KW - Biochemical analysis KW - Public health KW - Influenza KW - pandemics KW - ANE, Europe KW - Risk factors KW - Exo- alpha -sialidase KW - Asia KW - ANW, Canada KW - Fowl plague KW - USA KW - RNA KW - surface antigens KW - Proteins KW - Progeny KW - Outbreaks KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808612563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Molecular+Characterizations+of+Surface+Proteins+Hemagglutinin+and+Neuraminidase+from+Recent+H5Nx+Avian+Influenza+Viruses&rft.au=Yang%2C+Hua%3BCarney%2C+Paul+J%3BMishin%2C+Vasiliy+P%3BGuo%2C+Zhu%3BChang%2C+Jessie+C%3BWentworth%2C+David+E%3BGubareva%2C+Larisa+V%3BStevens%2C+James&rft.aulast=Yang&rft.aufirst=Hua&rft.date=2016-06-01&rft.volume=90&rft.issue=12&rft.spage=5770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00180-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 75 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Risk assessment; Fowl plague; Poultry; pandemics; RNA; surface antigens; Risk factors; Hemagglutinins; Biochemical analysis; Progeny; Exo- alpha -sialidase; Public health; Influenza; Viruses; Proteins; Outbreaks; USA; ANE, Europe; ANW, Canada; Asia DO - http://dx.doi.org/10.1128/JVI.00180-16 ER - TY - JOUR T1 - Cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women AN - 1808610060; PQ0003264670 AB - Objective To evaluate the cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women using data from three recent influenza seasons in the United States. Design, setting, and participants We developed a decision-analytic model following a cohort of 5.2 million pregnant women and their infants aged <6 months to evaluate the cost-effectiveness of vaccinating women against seasonal influenza during pregnancy from a societal perspective. The main outcome measures were quality-adjusted life-year (QALY) gained and cost-effectiveness ratios. Data sources included surveillance data, epidemiological studies, and published vaccine cost data. Sensitivity analyses were also performed. All costs and outcomes were discounted at 3% annually. Main outcome measures Total costs (direct and indirect), effects (QALY gains, averted case numbers), and incremental cost-effectiveness of seasonal inactivated influenza vaccination among pregnant women (cost per QALY gained). Results Using a recent benchmark of 52.2% vaccination coverage among pregnant women, we studied a hypothetical cohort of 2,753,015 vaccinated pregnant women. With an estimated vaccine effectiveness of 73% among pregnant women and 63% among infants <6 months, QALY gains for each season were 305 (2010-2011), 123 (2011-2012), and 610 (2012-2013). Compared with no vaccination, seasonal influenza vaccination during pregnancy was cost-saving when using data from the 2010-2011 and 2012-2013 influenza seasons. The cost-effectiveness ratio was greater than $100,000/QALY with the 2011-2012 influenza season data, when CDC reported a low attack rate compared to other recent seasons. Conclusions Influenza vaccination for pregnant women can reduce morbidity from influenza in both pregnant women and their infants aged <6 months. Seasonal influenza vaccination during pregnancy is cost-saving during moderate to severe influenza seasons. JF - Vaccine AU - Xu, Jing AU - Zhou, Fangjun AU - Reed, Carrie AU - Chaves, Sandra S AU - Messonnier, Mark AU - Kim, Inkyu K AD - Immunization Service Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, USA Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3149 EP - 3155 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 27 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Seasonal influenza vaccination KW - Cost-effectiveness analysis KW - Pregnancy KW - Data processing KW - Vaccination KW - Cost benefit analysis KW - Morbidity KW - Models KW - Influenza KW - USA KW - Sulfur dioxide KW - Sensitivity analysis KW - Females KW - Vaccines KW - Benchmarks KW - Seasonal variations KW - Infants KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Cost-effectiveness+of+seasonal+inactivated+influenza+vaccination+among+pregnant+women&rft.au=Xu%2C+Jing%3BZhou%2C+Fangjun%3BReed%2C+Carrie%3BChaves%2C+Sandra+S%3BMessonnier%2C+Mark%3BKim%2C+Inkyu+K&rft.aulast=Xu&rft.aufirst=Jing&rft.date=2016-06-01&rft.volume=34&rft.issue=27&rft.spage=3149&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2016.04.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 43 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Influenza; Data processing; Vaccines; Vaccination; Morbidity; Models; Infants; Pregnancy; Sulfur dioxide; Sensitivity analysis; Females; Benchmarks; Seasonal variations; Cost benefit analysis; USA DO - http://dx.doi.org/10.1016/j.vaccine.2016.04.057 ER - TY - JOUR T1 - The Use of Economic Evaluation to Inform Newborn Screening Policy Decisions: The Washington State Experience AN - 1794162500 AB - Policy Points: Newborn screening not only saves lives but can also yield net societal economic benefit, in addition to benefits such as improved quality of life to affected individuals and families. Calculations of net economic benefit from newborn screening include the monetary equivalent of avoided deaths and reductions in costs of care for complications associated with late-diagnosed individuals minus the additional costs of screening, diagnosis, and treatment associated with prompt diagnosis. Since 2001 the Washington State Department of Health has successfully implemented an approach to conducting evidence-based economic evaluations of disorders proposed for addition to the state-mandated newborn screening panel. Context Economic evaluations can inform policy decisions on the expansion of newborn screening panels. This article documents the use of cost-benefit models in Washington State as part of the rule-making process that resulted in the implementation of screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency and 4 other metabolic disorders in 2004, cystic fibrosis (CF) in 2006, 15 other metabolic disorders in 2008, and severe combined immune deficiency (SCID) in 2014. Methods We reviewed Washington State Department of Health internal reports and spreadsheet models of expected net societal benefit of adding disorders to the state newborn screening panel. We summarize the assumptions and findings for 2 models (MCAD and CF) and discuss them in relation to findings in the peer-reviewed literature. Findings The MCAD model projected a benefit-cost ratio of 3.4 to 1 based on assumptions of a 20.0 percentage point reduction in infant mortality and a 13.9 percentage point reduction in serious developmental disability. The CF model projected a benefit-cost ratio of 4.0-5.4 to 1 for a discount rate of 3%-4% and a plausible range of 1-2 percentage point reductions in deaths up to age 10 years. Conclusions The Washington State cost-benefit models of newborn screening were broadly consistent with peer-reviewed literature, and their findings of net benefit appear to be robust to uncertainty in parameters. Public health newborn screening programs can develop their own capacity to project expected costs and benefits of expansion of newborn screening panels, although it would be most efficient if this capacity were shared among programs. JF - The Milbank Quarterly AU - Grosse, SCOTT D AU - Thompson, JOHN D AU - Ding, YAO AU - Glass, MICHAEL AD - Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities ; Washington State Department of Health, Office of Newborn Screening ; Association of Public Health Laboratories ; Washington State Department of Health, Office of Newborn Screening; Deceased Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 366 EP - 391 CY - Oxford PB - Wiley Subscription Services, Inc. VL - 94 IS - 2 SN - 0887-378X KW - Political Science KW - Medical screening KW - Costs KW - Cystic fibrosis KW - Metabolic disorders KW - Cystic KW - Uncertainty KW - Parameters KW - Mortality KW - Infant mortality KW - Cost benefit analysis KW - Quality of life KW - Disability KW - Screening KW - Health costs KW - Diagnosis KW - Cost analysis KW - Evidence based medicine KW - Public health KW - Public health policy KW - Public Health KW - Infant Mortality KW - Family Life KW - Cost-Benefit Analysis KW - Disorders KW - Health Care Services Policy KW - Quality of Life KW - Maternal and Infant Welfare KW - Handicapped KW - Rules and Practice KW - Implementation KW - Disability Recipients UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794162500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Milbank+Quarterly&rft.atitle=The+Use+of+Economic+Evaluation+to+Inform+Newborn+Screening+Policy+Decisions%3A+The+Washington+State+Experience&rft.au=Grosse%2C+SCOTT+D%3BThompson%2C+JOHN+D%3BDing%2C+YAO%3BGlass%2C+MICHAEL&rft.aulast=Grosse&rft.aufirst=SCOTT&rft.date=2016-06-01&rft.volume=94&rft.issue=2&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=The+Milbank+Quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2F1468-0009.12196 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Copyright - Copyright© 2016 Milbank Memorial Fund N1 - Last updated - 2016-06-21 DO - http://dx.doi.org/10.1111/1468-0009.12196 ER - TY - JOUR T1 - Impact and Cost-effectiveness of 3 Doses of 9-Valent Human Papillomavirus (HPV) Vaccine Among US Females Previously Vaccinated With 4-Valent HPV Vaccine AN - 1790950034; PQ0003120231 AB - Background.We estimated the potential impact and cost-effectiveness of providing 3-doses of nonavalent human papillomavirus (HPV) vaccine (9vHPV) to females aged 13-18 years who had previously completed a series of quadrivalent HPV vaccine (4vHPV), a strategy we refer to as "additional 9vHPV vaccination." Methods.We used 2 distinct models: (1) the simplified model, which is among the most basic of the published dynamic HPV models, and (2) the US HPV-ADVISE model, a complex, stochastic, individual-based transmission-dynamic model. Results.When assuming no 4vHPV cross-protection, the incremental cost per quality-adjusted life-year (QALY) gained by additional 9vHPV vaccination was $146 200 in the simplified model and $108 200 in the US HPV-ADVISE model ($191 800 when assuming 4vHPV cross-protection). In 1-way sensitivity analyses in the scenario of no 4vHPV cross-protection, the simplified model results ranged from $70 300 to $182 000, and the US HPV-ADVISE model results ranged from $97 600 to $118 900. Conclusions.The average cost per QALY gained by additional 9vHPV vaccination exceeded $100 000 in both models. However, the results varied considerably in sensitivity and uncertainty analyses. Additional 9vHPV vaccination is likely not as efficient as many other potential HPV vaccination strategies, such as increasing primary 9vHPV vaccine coverage. JF - Journal of Infectious Diseases AU - Chesson, Harrell W AU - Laprise, Jean-Francois AU - Brisson, Marc AU - Markowitz, Lauri E AD - Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, hChesson@cdc.gov Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 1694 EP - 1700 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 11 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - human papillomavirus KW - vaccine KW - cost-effectiveness analysis KW - vaccine impact KW - disease transmission models KW - Sensitivity KW - Cross-protection KW - Vaccination KW - Stochasticity KW - Cost benefit analysis KW - Models KW - Stochastic models KW - Sensitivity analysis KW - Infectious diseases KW - Females KW - Vaccines KW - Human papillomavirus KW - V 22490:Miscellaneous KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790950034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Impact+and+Cost-effectiveness+of+3+Doses+of+9-Valent+Human+Papillomavirus+%28HPV%29+Vaccine+Among+US+Females+Previously+Vaccinated+With+4-Valent+HPV+Vaccine&rft.au=Chesson%2C+Harrell+W%3BLaprise%2C+Jean-Francois%3BBrisson%2C+Marc%3BMarkowitz%2C+Lauri+E&rft.aulast=Chesson&rft.aufirst=Harrell&rft.date=2016-06-01&rft.volume=213&rft.issue=11&rft.spage=1694&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Cross-protection; Vaccines; Stochasticity; Vaccination; Models; Sensitivity; Stochastic models; Infectious diseases; Sensitivity analysis; Females; Cost benefit analysis; Human papillomavirus DO - http://dx.doi.org/10.1093/infdis/jiw046 ER - TY - JOUR T1 - In vitro antiviral activity of adenosine analog NITD008 against tick-borne flaviviruses. AN - 1786126486; 27016316 AB - There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study, we describe the in vitro antiviral activity of adenosine analog NITD008 against KFDV, AHFV, OHFV, as well as Tick-borne Encephalitis virus (TBEV). Alongside the well-established activity of NITD008 against mosquito-borne flaviviruses, our results have demonstrated the feasibility of identifying nucleoside analog inhibitors that have pan-flavivirus activity. Published by Elsevier B.V. JF - Antiviral research AU - Lo, Michael K AU - Shi, Pei-Yong AU - Chen, Yen-Liang AU - Flint, Mike AU - Spiropoulou, Christina F AD - Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: mko2@cdc.gov. ; Department of Biochemistry and Molecular Biology, Department of Phamarcology and Toxicology, Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Novartis Institute for Tropical Diseases, Singapore. Electronic address: peshi@utmb.edu. ; Novartis Institute for Tropical Diseases, Singapore. ; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: ccs8@cdc.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 46 EP - 49 VL - 130 KW - Index Medicus KW - Antiviral KW - Tick-borne KW - NITD008 KW - Nucleoside analog KW - Flavivirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786126486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+research&rft.atitle=In%C2%A0vitro+antiviral+activity+of+adenosine+analog+NITD008+against+tick-borne+flaviviruses.&rft.au=Lo%2C+Michael+K%3BShi%2C+Pei-Yong%3BChen%2C+Yen-Liang%3BFlint%2C+Mike%3BSpiropoulou%2C+Christina+F&rft.aulast=Lo&rft.aufirst=Michael&rft.date=2016-06-01&rft.volume=130&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Antiviral+research&rft.issn=1872-9096&rft_id=info:doi/10.1016%2Fj.antiviral.2016.03.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.antiviral.2016.03.013 ER - TY - JOUR T1 - Zika Virus and Birth Defects--Reviewing the Evidence for Causality. AN - 1790465432; 27074377 JF - The New England journal of medicine AU - Rasmussen, Sonja A AU - Jamieson, Denise J AU - Honein, Margaret A AU - Petersen, Lyle R AD - From the Division of Public Health Information Dissemination, Center for Surveillance, Epidemiology, and Laboratory Services (S.A.R.), Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion (D.J.J.), and Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities (M.A.H.), Centers for Disease Control and Prevention, Atlanta; and the Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO (L.R.P.). Y1 - 2016/05/19/ PY - 2016 DA - 2016 May 19 SP - 1981 EP - 1987 VL - 374 IS - 20 KW - Abridged Index Medicus KW - Index Medicus KW - Causality KW - Humans KW - Brazil -- epidemiology KW - Zika Virus KW - Microcephaly -- epidemiology KW - Zika Virus Infection -- complications KW - Microcephaly -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790465432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Zika+Virus+and+Birth+Defects--Reviewing+the+Evidence+for+Causality.&rft.au=Rasmussen%2C+Sonja+A%3BJamieson%2C+Denise+J%3BHonein%2C+Margaret+A%3BPetersen%2C+Lyle+R&rft.aulast=Rasmussen&rft.aufirst=Sonja&rft.date=2016-05-19&rft.volume=374&rft.issue=20&rft.spage=1981&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMsr1604338 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-03 N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMsr1604338 ER - TY - JOUR T1 - Meningococcal vaccination for international travellers from Greece visiting developing countries AN - 1808634776; PQ0003320996 AB - Background Meningococcal meningitis is a serious disease. Travel-associated infection for the general traveller is low; however regular epidemics in indigenous population, particularly in sub-Saharan Africa are responsible for significant morbidity and mortality. Our aim was to assess meningococcal vaccination for international travellers from Greece. Methods A prospective questionnaire-based study was conducted during 2009-2013. Results A total of 5283 travellers were studied (median age: 39.2 years); Meningococcal tetravalent vaccine (A,C,W135,Y) was delivered to 1150 (21.8%) of them. Of those who travelled to the Middle East and sub-Saharan Africa, 73.1% and 21.2% received meningococcal vaccine, respectively. Of those travellers who travelled to sub-Saharan Africa from November to June and from July to October, 22.1% and 20.6% were vaccinated with meningococcal vaccine, respectively. Of all travellers who travelled for <1 month and greater than or equal to 1 month, 23.3%, and 20.5%, were vaccinated, respectively. Meningococcal vaccine was administered to 95.3% of pilgrims, 17.4% of those visiting friends and relatives (VFRs), 16.7% of those who travelled for recreation, and 13.8% of those who travelled for work. Of travellers who stayed in urban, in rural, and in urban and rural areas, 32%, 11.6% and 12.7% were vaccinated, respectively. Meningococcal vaccine was delivered to 29.2%, 21.1%, 19.4% and 5.1% of those who stayed in hotels, at local people's home, in camps, and on ships, respectively. The association of meningococcal vaccine administration with the destination, duration and purpose of travel, area of stay and type of accommodation was statistically significant. Conclusion There is a need to improve meningococcal vaccine recommendations for travellers from Greece, particularly for high risk populations, such as VFRs, business travellers and those visiting sub-Saharan Africa especially during the dry season. JF - Travel Medicine and Infectious Disease AU - Pavli, Androula AU - Katerelos, Panagiotis AU - Smeti, Paraskevi AU - Maltezou, Helena C AD - Travel Medicine Office, Hellenic Center for Disease Control and Prevention, Athens, Greece Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 261 EP - 266 PB - Elsevier VL - 14 IS - 3 SN - 1477-8939, 1477-8939 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Pre-travel KW - Meningitis KW - Vaccination KW - Travellers KW - Travel KW - Mortality KW - Age KW - Epidemics KW - Cyclic AMP KW - Statistical analysis KW - Neisseria meningitidis KW - Infection KW - Morbidity KW - Recreation KW - Risk factors KW - Vaccines KW - Developing countries KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808634776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Contribution+of+the+BacT%2FAlert+MB+Mycobacterium+Bottle+to+Bloodstream+Infection+Surveillance+in+Thailand%3A+Added+Yield+for+Burkholderia+pseudomallei&rft.au=Jorakate%2C+Possawat%3BHigdon%2C+Melissa%3BKaewpan%2C+Anek%3BMakprasert%2C+Sirirat%3BYuenprakhon%2C+Somkhit%3BTawisaid%2C+Kittisak%3BDejsirilert%2C+Surang%3BWhistler%2C+Toni%3BBaggett%2C+Henry+C&rft.aulast=Jorakate&rft.aufirst=Possawat&rft.date=2015-03-01&rft.volume=53&rft.issue=3&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02008-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 20 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Travel; Mortality; Age; Epidemics; Cyclic AMP; Travellers; Statistical analysis; Infection; Vaccination; Morbidity; Meningitis; Recreation; Risk factors; Vaccines; Developing countries; Neisseria meningitidis DO - http://dx.doi.org/10.1016/j.tmaid.2016.03.001 ER - TY - JOUR T1 - Changes in the medical management of patients on opioid analgesics following a diagnosis of substance abuse AN - 1805493576; PQ0003007119 AB - Purpose When providers recognize that patients are abusing prescription drugs, review of the drugs they are prescribed and attempts to treat the substance use disorder are warranted. However, little is known about whether prescribing patterns change following such a diagnosis. Methods We used national longitudinal health claims data from the Market Scan registered commercial claims database for January 2010-June 2011. We used a cohort of 1.85 million adults 18-64years old prescribed opioid analgesics but without abuse diagnoses during a 6-month "preabuse" period. We identified a subset of 9009 patients receiving diagnoses of abuse of non-illicit drugs (abuse group) during a 6-month "abuse" period and compared them with patients without such a diagnosis (nonabuse group) during both the abuse period and a subsequent 6-month "postabuse" period. Results During the abuse period 5.78% of the abuse group and 0.14% of the nonabuse group overdosed. Overdose rates declined to 2.12% in the abuse group in the postabuse period. Opioid prescribing rates declined 13.5%, and benzodiazepine rates declined 12.3% in the abuse group in the post-abuse period. Antidepressants and gabapentin were prescribed to roughly one half and one quarter of the abuse group, respectively, during all three periods. Daily opioid dosage did not decline in the abuse group following diagnosis. Conclusions Prescribing to people who abuse drugs changes little after their abuse is documented. Actions such as tapering opioid and benzodiazepine prescriptions, maximizing alternative treatments for pain, and greater use of medication-assisted treatment such as buprenorphine could help reduce risk in this population. JF - Pharmacoepidemiology and Drug Safety AU - Paulozzi, Leonard J AU - Zhou, Chao AU - Jones, Christopher M AU - Xu, Likang AU - Florence, Curtis S AD - National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 545 EP - 552 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 5 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - gabapentin KW - Antidepressants KW - Databases KW - Overdose KW - Buprenorphine KW - Data processing KW - Benzodiazepine KW - Opioids KW - Pain KW - Analgesics KW - Drug abuse KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805493576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Changes+in+the+medical+management+of+patients+on+opioid+analgesics+following+a+diagnosis+of+substance+abuse&rft.au=Paulozzi%2C+Leonard+J%3BZhou%2C+Chao%3BJones%2C+Christopher+M%3BXu%2C+Likang%3BFlorence%2C+Curtis+S&rft.aulast=Paulozzi&rft.aufirst=Leonard&rft.date=2016-05-01&rft.volume=25&rft.issue=5&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.3980 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - gabapentin; Databases; Antidepressants; Buprenorphine; Overdose; Data processing; Benzodiazepine; Pain; Opioids; Analgesics; Drug abuse DO - http://dx.doi.org/10.1002/pds.3980 ER - TY - JOUR T1 - Multicenter Evaluation of Clinical Diagnostic Methods for Detection and Isolation of Campylobacter spp. from Stool AN - 1794495707; PQ0003096682 AB - The use of culture-independent diagnostic tests (CIDTs), such as stool antigen tests, as standalone tests for the detection of Campylobacter in stool is increasing. We conducted a prospective, multicenter study to evaluate the performance of stool antigen CIDTs compared to culture and PCR for Campylobacter detection. Between July and October 2010, we tested 2,767 stool specimens from patients with gastrointestinal illness with the following methods: four types of Campylobacter selective media, four commercial stool antigen assays, and a commercial PCR assay. Illnesses from which specimens were positive by one or more culture media or at least one CIDT and PCR were designated "cases." A total of 95 specimens (3.4%) met the case definition. The stool antigen CIDTs ranged from 79.6% to 87.6% in sensitivity, 95.9 to 99.5% in specificity, and 41.3 to 84.3% in positive predictive value. Culture alone detected 80/89 (89.9% sensitivity) Campylobacter jejuni/Campylobacter coli-positive cases. Of the 209 noncases that were positive by at least one CIDT, only one (0.48%) was positive by all four stool antigen tests, and 73% were positive by just one stool antigen test. The questionable relevance of unconfirmed positive stool antigen CIDT results was supported by the finding that noncases were less likely than cases to have gastrointestinal symptoms. Thus, while the tests were convenient to use, the sensitivity, specificity, and positive predictive value of Campylobacter stool antigen tests were highly variable. Given the relatively low incidence of Campylobacter disease and the generally poor diagnostic test characteristics, this study calls into question the use of commercially available stool antigen CIDTs as standalone tests for direct detection of Campylobacter in stool. JF - Journal of Clinical Microbiology AU - Fitzgerald, Collette AU - Patrick, Mary AU - Gonzalez, Anthony AU - Akin, Joshua AU - Polage, Christopher R AU - Wymore, Kate AU - Gillim-Ross, Laura AU - Xavier, Karen AU - Sadlowski, Jennifer AU - Monahan, Jan AD - << + $0, chf3@cdc.gov. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1209 EP - 1215 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 54 IS - 5 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Campylobacter jejuni KW - Polymerase chain reaction KW - Feces KW - Media (selective) KW - Media (culture) KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794495707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Multicenter+Evaluation+of+Clinical+Diagnostic+Methods+for+Detection+and+Isolation+of+Campylobacter+spp.+from+Stool&rft.au=Fitzgerald%2C+Collette%3BPatrick%2C+Mary%3BGonzalez%2C+Anthony%3BAkin%2C+Joshua%3BPolage%2C+Christopher+R%3BWymore%2C+Kate%3BGillim-Ross%2C+Laura%3BXavier%2C+Karen%3BSadlowski%2C+Jennifer%3BMonahan%2C+Jan&rft.aulast=Fitzgerald&rft.aufirst=Collette&rft.date=2016-05-01&rft.volume=54&rft.issue=5&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01925-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Number of references - 26 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Polymerase chain reaction; Feces; Media (selective); Media (culture); Campylobacter jejuni DO - http://dx.doi.org/10.1128/JCM.01925-15 ER - TY - JOUR T1 - Identification of Antigenic Glycans from Schistosoma mansoni by Using a Shotgun Egg Glycan Microarray AN - 1790971878; PQ0003049566 AB - Infection of mammals by the parasitic helminth Schistosoma mansoni induces antibodies to glycan antigens in worms and eggs, but the differential nature of the immune response among infected mammals is poorly understood. To better define these responses, we used a shotgun glycomics approach in which N-glycans from schistosome egg glycoproteins were prepared, derivatized, separated, and used to generate an egg shotgun glycan microarray. This array was interrogated with sera from infected mice, rhesus monkeys, and humans and with glycan-binding proteins and antibodies to gather information about the structures of antigenic glycans, which also were analyzed by mass spectrometry. A major glycan antigen targeted by IgG from different infected species is the FLDNF epitope [Fuc alpha 3GalNAc beta 4(Fuc alpha 3)GlcNAc-R], which is also recognized by the IgG monoclonal antibody F2D2. The FLDNF antigen is expressed by all life stages of the parasite in mammalian hosts, and F2D2 can kill schistosomula in vitro in a complement-dependent manner. Different antisera also recognized other glycan determinants, including core beta -xylose and highly fucosylated glycans. Thus, the natural shotgun glycan microarray of schistosome eggs is useful in identifying antigenic glycans and in developing new anti-glycan reagents that may have diagnostic applications and contribute to developing new vaccines against schistosomiasis. JF - Infection and Immunity AU - Mickum, Megan L AU - Prasanphanich, Nina Salinger AU - Song, Xuezheng AU - Dorabawila, Nelum AU - Mandalasi, Msano AU - Lasanajak, Yi AU - Luyai, Anthony AU - Secor, W Evan AU - Wilkins, Patricia P AU - Die, Irma Van AD - << + $0, kex9@cdc.gov. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1371 EP - 1386 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 84 IS - 5 SN - 0019-9567, 0019-9567 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Schistosoma mansoni KW - Parasites KW - Monoclonal antibodies KW - Developmental stages KW - Schistosomiasis KW - Polysaccharides KW - Infection KW - Mass spectroscopy KW - Eggs KW - Antisera KW - N-glycans KW - Immunoglobulin G KW - Macaca mulatta KW - Immune response KW - Vaccines KW - Glycoproteins KW - Epitopes KW - F 06905:Vaccines KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790971878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+of+Antigenic+Glycans+from+Schistosoma+mansoni+by+Using+a+Shotgun+Egg+Glycan+Microarray&rft.au=Mickum%2C+Megan+L%3BPrasanphanich%2C+Nina+Salinger%3BSong%2C+Xuezheng%3BDorabawila%2C+Nelum%3BMandalasi%2C+Msano%3BLasanajak%2C+Yi%3BLuyai%2C+Anthony%3BSecor%2C+W+Evan%3BWilkins%2C+Patricia+P%3BDie%2C+Irma+Van&rft.aulast=Mickum&rft.aufirst=Megan&rft.date=2016-05-01&rft.volume=84&rft.issue=5&rft.spage=1371&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01349-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 84 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Parasites; Monoclonal antibodies; Schistosomiasis; Developmental stages; Infection; Polysaccharides; Eggs; Mass spectroscopy; Antisera; N-glycans; Immunoglobulin G; Glycoproteins; Vaccines; Immune response; Epitopes; Schistosoma mansoni; Macaca mulatta DO - http://dx.doi.org/10.1128/IAI.01349-15 ER - TY - JOUR T1 - Vaccination with 2014-15 Seasonal Inactivated Influenza Vaccine Elicits Cross-Reactive Anti-HA Antibodies with Strong ADCC Against Antigenically Drifted Circulating H3N2 Virus in Humans AN - 1790956482; PQ0003049688 AB - It is well established that virus neutralizing (VN) antibodies to hemagglutinin (HA) antigens of influenza A viruses provide optimal protection against antigenically matched strains of influenza A viruses. In contrast, little is known about the potential role of HA-specific, non-neutralizing antibodies in protection against human influenza illness at present. In this study, we show that individuals vaccinated with the 2014-15 seasonal inactivated influenza vaccine displayed strong A/H3N2 HA-specific antibody-dependent cell-mediated cytotoxicity (ADCC) activities against an antigenically drifted H3N2 virus, despite poor induction of cross-reactive neutralizing antibodies against the antigenic variant. Given that passive transfer of influenza HA-monospecific immune sera with negligible levels of HA-specific VN antibodies can often confer considerable cross protection against lethal challenge with heterologous influenza viruses in animal models, it is conceivable that HA-specific, non-neutralizing antibodies may provide certain degree of cross protection against antigenically drifted influenza A viruses through ADCC in case of influenza vaccine mismatches. This may have important implications for public health. JF - Viral Immunology AU - Zhong, Weimin AU - Gross, FLiaini AU - Holiday, Crystal AU - Jefferson, Stacie N AU - Bai, Yaohui AU - Liu, Feng AU - Katz, Jacqueline M AU - Levine, Min Z AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 259 EP - 262 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538 United States VL - 29 IS - 4 SN - 0882-8245, 0882-8245 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Antigenic variants KW - Immunology KW - Influenza A KW - Hemagglutinins KW - Viruses KW - Animal models KW - Vaccination KW - Public health KW - Influenza KW - Cytotoxicity KW - Antibodies KW - Sulfur dioxide KW - Antibody-dependent cell-mediated cytotoxicity KW - Vaccines KW - Seasonal variations KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790956482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Viral+Immunology&rft.atitle=Vaccination+with+2014-15+Seasonal+Inactivated+Influenza+Vaccine+Elicits+Cross-Reactive+Anti-HA+Antibodies+with+Strong+ADCC+Against+Antigenically+Drifted+Circulating+H3N2+Virus+in+Humans&rft.au=Zhong%2C+Weimin%3BGross%2C+FLiaini%3BHoliday%2C+Crystal%3BJefferson%2C+Stacie+N%3BBai%2C+Yaohui%3BLiu%2C+Feng%3BKatz%2C+Jacqueline+M%3BLevine%2C+Min+Z&rft.aulast=Zhong&rft.aufirst=Weimin&rft.date=2016-05-01&rft.volume=29&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Viral+Immunology&rft.issn=08828245&rft_id=info:doi/10.1089%2Fvim.2016.0003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 23 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Antigenic variants; Antibodies; Hemagglutinins; Influenza A; Animal models; Antibody-dependent cell-mediated cytotoxicity; Vaccines; Vaccination; Public health; Influenza; Cytotoxicity; Sulfur dioxide; Immunology; Viruses; Seasonal variations DO - http://dx.doi.org/10.1089/vim.2016.0003 ER - TY - JOUR T1 - Mammalian Pathogenesis and Transmission of H7N9 Influenza Viruses from Three Waves, 2013-2015 AN - 1790955484; PQ0003096748 AB - Three waves of human infection with H7N9 influenza viruses have concluded to date, but only viruses within the first wave (isolated between March and September 2013) have been extensively studied in mammalian models. While second- and third-wave viruses remain closely linked phylogenetically and antigenically, even subtle molecular changes can impart critical shifts in mammalian virulence. To determine if H7N9 viruses isolated from humans during 2013 to 2015 have maintained the phenotype first identified among 2013 isolates, we assessed the ability of first-, second-, and third-wave H7N9 viruses isolated from humans to cause disease in mice and ferrets and to transmit among ferrets. Similar to first-wave viruses, H7N9 viruses from 2013 to 2015 were highly infectious in mice, with lethality comparable to that of the well-studied A/Anhui/1/2013 virus. Second- and third-wave viruses caused moderate disease in ferrets, transmitted efficiently to cohoused, naive contact animals, and demonstrated limited transmissibility by respiratory droplets. All H7N9 viruses replicated efficiently in human bronchial epithelial cells, with subtle changes in pH fusion threshold identified between H7N9 viruses examined. Our results indicate that despite increased genetic diversity and geographical distribution since their initial detection in 2013, H7N9 viruses have maintained a pathogenic phenotype in mammals and continue to represent an immediate threat to public health. IMPORTANCE H7N9 influenza viruses, first isolated in 2013, continue to cause human infection and represent an ongoing public health threat. Now entering the fourth wave of human infection, H7N9 viruses continue to exhibit genetic diversity in avian hosts, necessitating continuous efforts to monitor their pandemic potential. However, viruses isolated post-2013 have not been extensively studied, limiting our understanding of potential changes in virus-host adaptation. In order to ensure that current research with first-wave H7N9 viruses still pertains to more recently isolated strains, we compared the relative virulence and transmissibility of H7N9 viruses isolated during the second and third waves, through 2015, in the mouse and ferret models. Our finding that second- and third-wave viruses generally exhibit disease in mammals comparable to that of first-wave viruses strengthens our ability to extrapolate research from the 2013 viruses to current public health efforts. These data further contribute to our understanding of molecular determinants of pathogenicity, transmissibility, and tropism. JF - Journal of Virology AU - Belser, Jessica A AU - Creager, Hannah M AU - Sun, Xiangjie AU - Gustin, Kortney M AU - Jones, Tara AU - Shieh, Wun-Ju AU - Maines, Taronna R AU - Tumpey, Terrence M AD - << + $0, tft9@cdc.gov. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 4647 EP - 4657 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 90 IS - 9 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Epithelial cells KW - Geographical distribution KW - Mammals KW - Viruses KW - Animal models KW - Genetic diversity KW - Infection KW - Public health KW - Disease transmission KW - Virulence KW - Influenza KW - pandemics KW - Mustela KW - Pathogenicity KW - Waves KW - pH effects KW - pH KW - Phylogeny KW - Data processing KW - Adaptations KW - Tropism KW - Mice KW - Adaptability KW - Lethality KW - Evolution KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790955484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Mammalian+Pathogenesis+and+Transmission+of+H7N9+Influenza+Viruses+from+Three+Waves%2C+2013-2015&rft.au=Belser%2C+Jessica+A%3BCreager%2C+Hannah+M%3BSun%2C+Xiangjie%3BGustin%2C+Kortney+M%3BJones%2C+Tara%3BShieh%2C+Wun-Ju%3BMaines%2C+Taronna+R%3BTumpey%2C+Terrence+M&rft.aulast=Belser&rft.aufirst=Jessica&rft.date=2016-05-01&rft.volume=90&rft.issue=9&rft.spage=4647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.00134-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 63 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Phylogeny; Epithelial cells; Geographical distribution; Adaptations; Data processing; Tropism; Animal models; Genetic diversity; Infection; Disease transmission; Public health; Influenza; Virulence; pandemics; Lethality; Pathogenicity; Waves; pH effects; Evolution; Adaptability; Mammals; Viruses; Mice; pH; Mustela DO - http://dx.doi.org/10.1128/JVI.00134-16 ER - TY - JOUR T1 - The Relationship Between Distance to Water Source and Moderate-to-Severe Diarrhea in the Global Enterics Multi-Center Study in Kenya, 2008-2011 AN - 1790947211; PQ0003120381 AB - In the developing world, fetching water for drinking and other household uses is a substantial burden that affects water quantity and quality in the household. We used logistic regression to examine whether reported household water fetching times were a risk factor for moderate-to-severe diarrhea (MSD) using case-control data of 3,359 households from the Global Enterics Multi-Center Study in Kenya in 2009-2011. We collected additional global positioning system (GPS) data for a subset of 254 randomly selected households and compared GPS-based straight line and actual travel path distances to fetching times reported by respondents. GPS-based data were highly correlated with respondent-provided times (Spearman correlation coefficient = 0.81, P 30 minutes was reported by 25% of cases versus 15% of controls and was significantly associated with MSD where rainwater was not used in the last 2 weeks (odds ratio = 1.97, 95% confidence interval = 1.56-2.49). These data support the United Nations definition of access to an improved water source being within 30 minutes total round-trip travel time. JF - American Journal of Tropical Medicine and Hygiene AU - Nygren, Benjamin L AU - O'Reilly, Ciara E AU - Rajasingham, Anangu AU - Omore, Richard AU - Ombok, Maurice AU - Awuor, Alex O AU - Jaron, Peter AU - Moke, Fenny AU - Vulule, John AU - Laserson, Kayla AD - National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, bnygren@cdc.gov Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 1143 EP - 1149 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 94 IS - 5 SN - 0002-9637, 0002-9637 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Travel KW - Data processing KW - Diarrhea KW - Positioning systems KW - Kenya KW - Depth perception KW - Households KW - Risk factors KW - International organizations KW - United Nations KW - Rain KW - Drinking water KW - Hygiene KW - Q5 08503:Characteristics, behavior and fate KW - K 03490:Miscellaneous KW - Q1 08563:Fishing gear and methods KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790947211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Relationship+Between+Distance+to+Water+Source+and+Moderate-to-Severe+Diarrhea+in+the+Global+Enterics+Multi-Center+Study+in+Kenya%2C+2008-2011&rft.au=Nygren%2C+Benjamin+L%3BO%27Reilly%2C+Ciara+E%3BRajasingham%2C+Anangu%3BOmore%2C+Richard%3BOmbok%2C+Maurice%3BAwuor%2C+Alex+O%3BJaron%2C+Peter%3BMoke%2C+Fenny%3BVulule%2C+John%3BLaserson%2C+Kayla&rft.aulast=Nygren&rft.aufirst=Benjamin&rft.date=2016-05-01&rft.volume=94&rft.issue=5&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Positioning systems; International organizations; Hygiene; Travel; Depth perception; Diarrhea; Data processing; Risk factors; Drinking water; Households; Rain; United Nations; Kenya DO - http://dx.doi.org/10.4269/ajtmh.15-0393 ER - TY - JOUR T1 - School Start Times, Sleep, Behavioral, Health, and Academic Outcomes: A Review of the Literature AN - 1777916387 AB - BACKGROUND Insufficient sleep in adolescents has been shown to be associated with a wide variety of adverse outcomes, from poor mental and physical health to behavioral problems and lower academic grades. However, most high school students do not get sufficient sleep. Delaying school start times for adolescents has been proposed as a policy change to address insufficient sleep in this population and potentially to improve students' academic performance, reduce engagement in risk behaviors, and improve health. METHODS This article reviews 38 reports examining the association between school start times, sleep, and other outcomes among adolescent students. RESULTS Most studies reviewed provide evidence that delaying school start time increases weeknight sleep duration among adolescents, primarily by delaying rise times. Most of the studies saw a significant increase in sleep duration even with relatively small delays in start times of half an hour or so. Later start times also generally correspond to improved attendance, less tardiness, less falling asleep in class, better grades, and fewer motor vehicle crashes. CONCLUSIONS Although additional research is necessary, research results that are already available should be disseminated to stakeholders to enable the development of evidence-based school policies. JF - The Journal of School Health AU - Wheaton, Anne G AU - Chapman, Daniel P AU - Croft, Janet B AD - Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy. NE, Mailstop F-78, Atlanta, GA ; Epidemiology and Surveillance Branch, Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy. NE Mailstop F-78, Atlanta, GA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 363 EP - 381 CY - Kent PB - Wiley Subscription Services, Inc. VL - 86 IS - 5 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Sleep KW - Academic achievement KW - Adolescents KW - Behavioural problems KW - Evidence based KW - Health behaviour KW - Health status KW - Literature reviews KW - Mental health KW - Policy making KW - Risk behaviour KW - Risk reduction KW - Stakeholders KW - Teenagers KW - Students KW - Behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777916387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=School+Start+Times%2C+Sleep%2C+Behavioral%2C+Health%2C+and+Academic+Outcomes%3A+A+Review+of+the+Literature&rft.au=Wheaton%2C+Anne+G%3BChapman%2C+Daniel+P%3BCroft%2C+Janet+B&rft.aulast=Wheaton&rft.aufirst=Anne&rft.date=2016-05-01&rft.volume=86&rft.issue=5&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12388 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016, American School Health Association N1 - Last updated - 2016-10-05 DO - http://dx.doi.org/10.1111/josh.12388 ER - TY - JOUR T1 - Measles Virus Neutralizing Antibody Response, Cell-Mediated Immunity, and Immunoglobulin G Antibody Avidity Before and After Receipt of a Third Dose of Measles, Mumps, and Rubella Vaccine in Young Adults AN - 1808729877; PQ0003170887 AB - Background.Two doses of measles, mumps, and rubella (MMR) vaccine are 97% effective against measles, but waning antibody immunity to measles and failure of the 2-dose vaccine occur. We administered a third MMR dose (MMR3) to young adults and assessed immunogenicity over 1 year. Methods.Measles virus (MeV) neutralizing antibody concentrations, cell-mediated immunity (CMI), and immunoglobulin G (IgG) antibody avidity were assessed at baseline and 1 month and 1 year after MMR3 receipt. Results.Of 662 subjects at baseline, 1 (0.2%) was seronegative for MeV-neutralizing antibodies (level, or =4-fold rise in neutralizing antibodies. One year after MMR3 receipt, no subject was seronegative, and 10 of 617 (1.6%) had low neutralizing antibody levels. CMI analyses showed low levels of spot-forming cells after stimulation, suggesting the presence of T-cell memory, but the response was minimal after MMR3 receipt. MeV IgG avidity did not correlate with findings of neutralization analyses. Conclusions.Most subjects were seropositive before MMR3 receipt, and very few had a secondary immune response after MMR3 receipt. Similarly, CMI and avidity analyses showed minimal qualitative improvements in immune response after MMR3 receipt. We did not find compelling data to support a routine third dose of MMR vaccine. JF - Journal of Infectious Diseases AU - Fiebelkorn, Amy Parker AU - Coleman, Laura A AU - Belongia, Edward A AU - Freeman, Sandra K AU - York, Daphne AU - Bi, Daoling AU - Kulkarni, Ashwin AU - Audet, Susette AU - Mercader, Sara AU - McGrew, Marcia AU - Hickman, Carole J AU - Bellini, William J AU - Shivakoti, Rupak AU - Griffin, Diane E AU - Beeler, Judith AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, afiebelkorn@cdc.gov Y1 - 2016/04/01/ PY - 2016 DA - 2016 Apr 01 SP - 1115 EP - 1123 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 7 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - measles KW - third dose of measles, mumps, rubella (MMR) vaccine KW - measles vaccine immunogenicity KW - vaccine-preventable disease KW - immunization KW - cell-mediated immunity KW - measles virus antibody avidity KW - Data processing KW - Measles KW - Immunological memory KW - Antibody response KW - Measles virus KW - Rubella KW - Infectious diseases KW - Immunity (cell-mediated) KW - Immunogenicity KW - Avidity KW - Lymphocytes T KW - Immunoglobulin G KW - Young adults KW - Immune response KW - Vaccines KW - Neutralization KW - Mumps KW - V 22350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808729877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Measles+Virus+Neutralizing+Antibody+Response%2C+Cell-Mediated+Immunity%2C+and+Immunoglobulin+G+Antibody+Avidity+Before+and+After+Receipt+of+a+Third+Dose+of+Measles%2C+Mumps%2C+and+Rubella+Vaccine+in+Young+Adults&rft.au=Fiebelkorn%2C+Amy+Parker%3BColeman%2C+Laura+A%3BBelongia%2C+Edward+A%3BFreeman%2C+Sandra+K%3BYork%2C+Daphne%3BBi%2C+Daoling%3BKulkarni%2C+Ashwin%3BAudet%2C+Susette%3BMercader%2C+Sara%3BMcGrew%2C+Marcia%3BHickman%2C+Carole+J%3BBellini%2C+William+J%3BShivakoti%2C+Rupak%3BGriffin%2C+Diane+E%3BBeeler%2C+Judith&rft.aulast=Fiebelkorn&rft.aufirst=Amy&rft.date=2016-04-01&rft.volume=213&rft.issue=7&rft.spage=1115&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv555 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Data processing; Measles; Immunological memory; Antibody response; Rubella; Immunity (cell-mediated); Avidity; Immunogenicity; Immunoglobulin G; Lymphocytes T; Vaccines; Immune response; Mumps; Infectious diseases; Young adults; Neutralization; Measles virus DO - http://dx.doi.org/10.1093/infdis/jiv555 ER - TY - JOUR T1 - Enhanced surveillance of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines in pregnancy in the Vaccine Adverse Event Reporting System (VAERS), 2011-2015 AN - 1787985767; PQ0002951534 AB - Background In October 2011, the Advisory Committee on Immunization Practices (ACIP) issued updated recommendations that all pregnant women routinely receive a dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine. Objectives We characterized reports to the Vaccine Adverse Event Reporting System (VAERS) in pregnant women who received Tdap after this updated recommendation (2011-2015) and compared the pattern of adverse events (AEs) with the period before the updated recommendation (2005-2010). Methods We searched the VAERS database for reports of AEs in pregnant women who received Tdap vaccine after the routine recommendation (11/01/2011-6/30/2015) and compared it to published data before the routine Tdap recommendation (01/01/2005-06/30/2010). We conducted clinical review of reports and available medical records. The clinical pattern of reports in the post-recommendation period was compared with the pattern before the routine Tdap recommendation. Results We found 392 reports of Tdap vaccination after the routine recommendation. One neonatal death but no maternal deaths were reported. No maternal or neonatal deaths were reported before the recommendation. We observed an increase in proportion of reports for stillbirths (1.5-2.8%) and injection site reactions/arm pain (4.5-11.9%) after the recommendation compared to the period before the routine recommendation for Tdap during pregnancy. We noted a decrease in reports of spontaneous abortion (16.7-1%). After the 2011 Tdap recommendation, in most reports, vaccination (79%) occurred during the third trimester compared to 4% before the 2011 Tdap recommendation. Twenty-six reports of repeat Tdap were received in VAERS; 13 did not report an AE. One medical facility accounted for 27% of all submitted reports. Conclusions No new or unexpected vaccine AEs were noted among pregnant women who received Tdap after routine recommendations for maternal Tdap vaccination. Changes in reporting patterns would be expected, given the broader use of Tdap in pregnant women in the third trimester. JF - Vaccine AU - Moro, Pedro L AU - Cragan, Janet AU - Tepper, Naomi AU - Zheteyeva, Yenlik AU - Museru, Oidda AU - Lewis, Paige AU - Broder, Karen AD - Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, MS D26, Atlanta, GA 30333, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 2349 EP - 2353 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 20 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Immunology Abstracts KW - Adverse events KW - Epidemiology KW - Tdap KW - Pregnancy KW - Surveillance KW - Vaccine safety KW - Pertussis KW - Abortion KW - Pain KW - Toxoids KW - Tetanus KW - Mortality KW - Data processing KW - medical records KW - Advisory committees KW - Diphtheria KW - Vaccination KW - Immunization KW - Databases KW - Reviews KW - Neonates KW - Vaccines KW - Side effects KW - F 06905:Vaccines KW - J 02350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787985767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhanced+surveillance+of+tetanus+toxoid%2C+reduced+diphtheria+toxoid%2C+and+acellular+pertussis+%28Tdap%29+vaccines+in+pregnancy+in+the+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%2C+2011-2015&rft.au=Moro%2C+Pedro+L%3BCragan%2C+Janet%3BTepper%2C+Naomi%3BZheteyeva%2C+Yenlik%3BMuseru%2C+Oidda%3BLewis%2C+Paige%3BBroder%2C+Karen&rft.aulast=Moro&rft.aufirst=Pedro&rft.date=2016-04-01&rft.volume=34&rft.issue=20&rft.spage=2349&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2016.03.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 16 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Pertussis; Data processing; medical records; Abortion; Pain; Toxoids; Diphtheria; Tetanus; Vaccination; Pregnancy; Databases; Reviews; Vaccines; Neonates; Mortality; Advisory committees; Immunization; Side effects DO - http://dx.doi.org/10.1016/j.vaccine.2016.03.049 ER - TY - JOUR T1 - Preventive malaria treatment for contacts of patients with Ebola virus disease in the context of the west Africa 2014-15 Ebola virus disease response: an economic analysis AN - 1785231345; PQ0002849097 AB - Background After the detection of an Ebola virus disease outbreak in west Africa in 2014, one of the elements of the response was to contact trace and isolate patients in specialised Ebola treatment units (ETUs) at onset of fever. We aimed to assess the economic feasibility of administering preventive malaria treatment to all contacts of patients with Ebola virus disease, to prevent the onset of febrile malaria and subsequent admission to ETUs. Methods We used a decision tree model to analyse the costs of preventive malaria treatment (artemisinin-based combination treatment [ACT]) for all contacts of patients with Ebola virus disease (in terms of administration and averted ETU-stay costs) and benefits (in terms of averted ETU admissions) in west Africa, from a health-care provider perspective. The period of analyses was 1 year, which is roughly similar to the duration of the 2014-15 west Africa Ebola outbreak response. We calculated the intervention's cost per ETU admission averted (average cost-effectiveness ratio) by season (wet and dry), country (Liberia, Sierra Leone, and Guinea), and age of contact (<5 years, 5-14 years, and greater than or equal to 15 years). We did sensitivity analyses to assess how results varied with malaria parasite prevalence (in children aged 2-10 years), daily cost of ETU stay (for Liberian malaria incidence levels), and compliance and effectiveness of preventive malaria treatment. Findings Administration of ACTs to contacts of patients with Ebola virus disease was cost saving for contacts of all ages in Liberia, Sierra Leone, and Guinea, in both seasons, from a health-care provider perspective. In the wet season, preventive malaria treatment was estimated to reduce the probability of a contact being admitted to an ETU by a maximum of 36% (in Guinea, for contacts aged <5 years), and a minimum of 10% (in Guinea and Sierra Leone, for those aged greater than or equal to 15 years). Assuming 85% compliance and taking into account the African population pyramid, the intervention is expected to be cost saving in contacts of all age groups in areas with malaria parasite prevalence in children aged 2-10 years as low as 10%. In Liberia during the wet season, malaria preventive treatment was cost saving even when average daily bed-stay costs were as low as US$5 for children younger than 5 years, $9 for those aged 5-14 years, and $22 for those aged 15 years or older. Interpretation Administration of preventive malaria treatment to contacts of patients with Ebola virus disease should be considered by public health officials when addressing Ebola virus disease outbreaks in countries and seasons where malaria reaches high levels of transmission. Funding Centers for Disease Control and Prevention. JF - Lancet Infectious Diseases AU - Carias, Cristina AU - Greening, Bradford Jr AU - Campbell, Caresse G AU - Meltzer, Martin I AU - Hamel, Mary J AD - National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 449 EP - 458 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 16 IS - 4 SN - 1473-3099, 1473-3099 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Age KW - Human diseases KW - Disease control KW - Ebola virus KW - Malaria KW - Models KW - Public health KW - Disease transmission KW - Liberia KW - Fever KW - Economic feasibility KW - Rainy season KW - Guinea KW - Economics KW - Sierra Leone KW - Age determination KW - Children KW - Africa KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785231345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Changes+in+Knowledge+of+Bat+Rabies+and+Human+Exposure+among+United+States+Cavers&rft.au=Mehal%2C+Jason+M%3BHolman%2C+Robert+C%3BBrass%2C+Danny+A%3BBlanton%2C+Jesse+D%3BPetersen%2C+Brett+W&rft.aulast=Mehal&rft.aufirst=Jason&rft.date=2014-02-01&rft.volume=90&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 27 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Economic feasibility; Human diseases; Rainy season; Disease control; Malaria; Age determination; Disease transmission; Public health; Fever; Age; Economics; Children; Models; Ebola virus; Liberia; Guinea; Africa; Sierra Leone DO - http://dx.doi.org/10.1016/S1473-3099(15)00465-X ER - TY - JOUR T1 - Use and effectiveness of quitlines versus Web-based tobacco cessation interventions among 4 state tobacco control programs AN - 1780526200; PQ0002846731 AB - BACKGROUND Comparative effectiveness studies of state tobacco quitlines and Web-based tobacco cessation interventions are limited. In 2009, the US Centers for Disease Control and Prevention undertook a study of the comparative effectiveness of state quitlines and Web-based tobacco cessation interventions. METHODS Standardized questionnaires were administered to smokers who enrolled exclusively in either quitlines or Web-based tobacco cessation services in 4 states in 2011-2012. The primary outcome was the 30-day point prevalence abstinence (PPA) rate at 7 months both between and within interventions. RESULTS A total of 4086 participants were included in the analysis. Quitline users were significantly older, more heterogeneous in terms of race and ethnicity, less educated, less likely to be employed, and more often single than Web-based users. The 7-month 30-day PPA rate was 32% for quitline users and 27% for Web-based users. Multivariate models comparing 30-day PPA rates between interventions indicated that significantly increased odds of quitting were associated with being partnered, not living with another smoker, low baseline cigarette use, and more interactions with the intervention. After adjustments for demographic and tobacco use characteristics, quitline users had 1.26 the odds of being abstinent in comparison with Web-based users (95% confidence interval, 1.00-1.58; P = .053). CONCLUSIONS This is one of the largest comparative effectiveness studies of state tobacco cessation interventions to date. These findings will help public health agencies develop and tailor evidence-based tobacco cessation programs. Further research should focus on users of Web-based cessation interventions sponsored by state health departments and their cost-effectiveness. Cancer 2016; 122:1126-1133. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Limited information exists for comparing state quitlines and Web-based tobacco cessation interventions. Exclusive users of quitlines and Web-based interventions are different with respect to demographics and tobacco use. The intervention type approaches but does not meet statistical significance as a factor associated with 30-day abstinence measured at 7 months' follow-up in a model adjusted for demographics and tobacco use. JF - Cancer AU - Neri, Antonio J AU - Momin, Behnoosh R AU - Thompson, Trevor D AU - Kahende, Jennifer AU - Zhang, Lei AU - Puckett, Mary C AU - Stewart, Sherri L AD - Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1126 EP - 1133 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 122 IS - 7 SN - 0008-543X, 0008-543X KW - Toxicology Abstracts KW - Inventories KW - Statistics KW - Cigarettes KW - Control programs KW - Disease control KW - Statistical analysis KW - Cancer KW - Public health KW - Models KW - Demography KW - Tobacco KW - Races KW - Ethnic groups KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780526200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Use+and+effectiveness+of+quitlines+versus+Web-based+tobacco+cessation+interventions+among+4+state+tobacco+control+programs&rft.au=Neri%2C+Antonio+J%3BMomin%2C+Behnoosh+R%3BThompson%2C+Trevor+D%3BKahende%2C+Jennifer%3BZhang%2C+Lei%3BPuckett%2C+Mary+C%3BStewart%2C+Sherri+L&rft.aulast=Neri&rft.aufirst=Antonio&rft.date=2016-04-01&rft.volume=77&rft.issue=5&rft.spage=1728&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Inventories; Statistics; Cigarettes; Control programs; Statistical analysis; Disease control; Cancer; Models; Public health; Demography; Tobacco; Ethnic groups; Races DO - http://dx.doi.org/10.1002/cncr.29739 ER - TY - JOUR T1 - Impact and cost-effectiveness of a second tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine dose to prevent pertussis in the United States AN - 1776670629; PQ0002810163 AB - Introduction The United States experienced a substantial increase in reported pertussis cases over the last decade. Since 2005, persons 11 years and older have been routinely recommended to receive a single dose of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis (Tdap) vaccine. The objective of this analysis was to evaluate the potential impact and cost-effectiveness of recommending a second dose of Tdap. Methods A static cohort model was used to calculate the epidemiologic and economic impact of adding a second dose of Tdap at age 16 or 21 years. Projected costs and outcomes were examined from a societal perspective over a 20-year period. Quality-adjusted Life Years (QALY) saved were calculated. Results Using baseline pertussis incidence from the National Notifiable Diseases Surveillance System, Tdap revaccination at either age 16 or 21 years would reduce outpatient visits by 433 (5%) and 285 (4%), and hospitalization cases by 7 (7%) and 5 (5%), respectively. The costs per QALY saved with a second dose of Tdap were approximately US $19.7 million (16 years) and $26.2 million (21 years). In sensitivity analyses, incidence most influenced the model; as incidence increased, the costs per QALY decreased. To a lesser degree, initial vaccine effectiveness and waning of effectiveness also affected cost outcomes. Multivariate sensitivity analyses showed that under a set of optimistic assumptions, the cost per QALY saved would be approximately $163,361 (16 years) and $204,556 (21 years). Conclusion A second dose of Tdap resulted in a slight decrease in the number of cases and other outcomes, and that trend is more apparent when revaccinating at age 16 years than at age 21 years. Both revaccination strategies had high dollar per QALY saved even under optimistic assumptions in a multivariate sensitivity analysis. JF - Vaccine AU - Kamiya, Hajime AU - Cho, Bo-Hyun AU - Messonnier, Mark L AU - Clark, Thomas A AU - Liang, Jennifer L AD - Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology and Laboratory Services, Centers for Disease Control and Prevention, 1600 Clifton Rd, N.E., Atlanta, GA 30329-4027, United States Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1832 EP - 1838 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 15 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Immunology Abstracts KW - Pertussis KW - Cost-effectiveness KW - Tdap KW - Revaccination KW - Adolescent KW - Adult KW - Age KW - Toxoids KW - Diphtheria KW - Tetanus KW - Cost benefit analysis KW - Models KW - USA KW - Sensitivity analysis KW - Economics KW - Vaccines KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776670629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Impact+and+cost-effectiveness+of+a+second+tetanus+toxoid%2C+reduced+diphtheria+toxoid%2C+and+acellular+pertussis+%28Tdap%29+vaccine+dose+to+prevent+pertussis+in+the+United+States&rft.au=Kamiya%2C+Hajime%3BCho%2C+Bo-Hyun%3BMessonnier%2C+Mark+L%3BClark%2C+Thomas+A%3BLiang%2C+Jennifer+L&rft.aulast=Kamiya&rft.aufirst=Hajime&rft.date=2016-04-01&rft.volume=34&rft.issue=15&rft.spage=1832&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2016.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 23 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Pertussis; Age; Economics; Diphtheria; Toxoids; Vaccines; Tetanus; Models; Sensitivity analysis; Cost benefit analysis; USA DO - http://dx.doi.org/10.1016/j.vaccine.2016.02.027 ER - TY - JOUR T1 - Beliefs, Behaviors, and Perceptions of Community-Led Total Sanitation and Their Relation to Improved Sanitation in Rural Zambia AN - 1787968999; PQ0002948309 AB - Inadequate hygiene and sanitation remain leading global contributors to morbidity and mortality in children and adults. One strategy for improving sanitation access is community-led total sanitation (CLTS), in which participants are guided into self-realization of the importance of sanitation through activities called "triggering." This qualitative study explored community members' and stakeholders' sanitation, knowledge, perceptions, and behaviors during early CLTS implementation in Zambia. We conducted 67 in-depth interviews and 24 focus group discussions in six districts in Zambia 12-18 months after CLTS implementation. Triggering activities elicited strong emotions, including shame, disgust, and peer pressure, which persuaded individuals and families to build and use latrines and handwashing stations. New sanitation behaviors were also encouraged by the hierarchical influences of traditional leaders and sanitation action groups and by children's opinions. Poor soil conditions were identified as barriers to latrine construction. Taboos, including prohibition of different generations of family members, in-laws, and opposite genders from using the same toilet, were barriers for using sanitation facilities. CLTS, through community empowerment and ownership, produced powerful responses that encouraged construction and use of latrines and handwashing practices. These qualitative data suggest that CLTS is effective for improving sanitation beliefs and behaviors in Zambia. JF - American Journal of Tropical Medicine and Hygiene AU - Lawrence, J Joseph AU - Yeboah-Antwi, Kojo AU - Biemba, Godfrey AU - Ram, Pavani K AU - Osbert, Nicolas AU - Sabin, Lora L AU - Hamer, Davidson H AD - Zambia Center for Applied Health Research and Development, Lusaka, Zambia, ymq1@cdc.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 553 EP - 562 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 94 IS - 3 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Stakeholders KW - Emotions KW - Barriers KW - Morbidity KW - Soil KW - Sanitation KW - Soils KW - Empowerment KW - Pressure KW - Sex KW - Mortality KW - Data processing KW - Toilets KW - Children KW - Zambia KW - Behavior KW - Perception KW - Gender KW - Property rights KW - Hygiene KW - Mortality causes KW - Rural areas KW - K 03400:Human Diseases KW - Q1 08442:Population dynamics KW - Q5 08504:Effects on organisms KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787968999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Beliefs%2C+Behaviors%2C+and+Perceptions+of+Community-Led+Total+Sanitation+and+Their+Relation+to+Improved+Sanitation+in+Rural+Zambia&rft.au=Lawrence%2C+J+Joseph%3BYeboah-Antwi%2C+Kojo%3BBiemba%2C+Godfrey%3BRam%2C+Pavani+K%3BOsbert%2C+Nicolas%3BSabin%2C+Lora+L%3BHamer%2C+Davidson+H&rft.aulast=Lawrence&rft.aufirst=J&rft.date=2016-03-01&rft.volume=94&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0335 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Barriers; Soils; Property rights; Hygiene; Mortality causes; Sex; Soil; Mortality; Emotions; Data processing; Sanitation; Toilets; Perception; Pressure; Children; Morbidity; Stakeholders; Behavior; Gender; Empowerment; Rural areas; Zambia DO - http://dx.doi.org/10.4269/ajtmh.15-0335 ER - TY - JOUR T1 - Humanized Mouse Model of Ebola Virus Disease Mimics the Immune Responses in Human Disease AN - 1780499309; PQ0002893205 AB - Animal models recapitulating human Ebola virus disease (EVD) are critical for insights into virus pathogenesis. Ebola virus (EBOV) isolates derived directly from human specimens do not, without adaptation, cause disease in immunocompetent adult rodents. Here, we describe EVD in mice engrafted with human immune cells (hu-BLT). hu-BLT mice developed EVD following wild-type EBOV infection. Infection with high-dose EBOV resulted in rapid, lethal EVD with high viral loads, alterations in key human antiviral immune cytokines and chemokines, and severe histopathologic findings similar to those shown in the limited human postmortem data available. A dose- and donor-dependent clinical course was observed in hu-BLT mice infected with lower doses of either Mayinga (1976) or Makona (2014) isolates derived from human EBOV cases. Engraftment of the human cellular immune system appeared to be essential for the observed virulence, as nonengrafted mice did not support productive EBOV replication or develop lethal disease. hu-BLT mice offer a unique model for investigating the human immune response in EVD and an alternative animal model for EVD pathogenesis studies and therapeutic screening. JF - Journal of Infectious Diseases AU - Bird, Brian H AU - Spengler, Jessica R AU - Chakrabarti, Ayan K AU - Khristova, Marina L AU - Sealy, Tara K AU - Coleman-Mccray, Joann D AU - Martin, Brock E AU - Dodd, Kimberly A AU - Goldsmith, Cynthia S AU - Sanders, Jeanine AU - Zaki, Sherif R AU - Nichol, Stuart T AU - Spiropoulou, Christina F AD - Viral Special Pathogens Branch, ccs8@cdc.gov Y1 - 2016/03/01/ PY - 2016 DA - 2016 Mar 01 SP - 703 EP - 711 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 5 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Ebola virus disease KW - animal model KW - viral hemorrhagic fever KW - humanized mice KW - cytokine profile KW - virus pathogenesis KW - Chemokines KW - Data processing KW - Adaptations KW - Replication KW - Immune system KW - Viruses KW - Animal models KW - Ebola virus KW - Mice KW - Infection KW - Virulence KW - Adaptability KW - Infectious diseases KW - Cytokines KW - Immune response KW - Rodents KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780499309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Humanized+Mouse+Model+of+Ebola+Virus+Disease+Mimics+the+Immune+Responses+in+Human+Disease&rft.au=Bird%2C+Brian+H%3BSpengler%2C+Jessica+R%3BChakrabarti%2C+Ayan+K%3BKhristova%2C+Marina+L%3BSealy%2C+Tara+K%3BColeman-Mccray%2C+Joann+D%3BMartin%2C+Brock+E%3BDodd%2C+Kimberly+A%3BGoldsmith%2C+Cynthia+S%3BSanders%2C+Jeanine%3BZaki%2C+Sherif+R%3BNichol%2C+Stuart+T%3BSpiropoulou%2C+Christina+F&rft.aulast=Bird&rft.aufirst=Brian&rft.date=2016-03-01&rft.volume=213&rft.issue=5&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv538 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Virulence; Chemokines; Adaptations; Data processing; Replication; Animal models; Cytokines; Immune response; Infection; Adaptability; Infectious diseases; Immune system; Viruses; Mice; Rodents; Ebola virus DO - http://dx.doi.org/10.1093/infdis/jiv538 ER - TY - JOUR T1 - HPV vaccination coverage of teen girls: The influence of health care providers AN - 1773849347; PQ0002717350 AB - Background Between 2010 and 2014, the percentage of 13-17 year-old girls administered greater than or equal to 3 doses of the human papilloma virus (HPV) vaccine ("fully vaccinated") increased by 7.7 percentage points to 39.7%, and the percentage not administered any doses of the HPV vaccine ("not immunized") decreased by 11.3 percentage points to 40.0%. Objective To evaluate the complex interactions between parents' vaccine-related beliefs, demographic factors, and HPV immunization status. Methods Vaccine-related parental beliefs and sociodemographic data collected by the 2010 National Immunization Survey-Teen among teen girls (n=8490) were analyzed. HPV vaccination status was determined from teens' health care provider (HCP) records. Results Among teen girls either unvaccinated or fully vaccinated against HPV, teen girls whose parent was positively influenced to vaccinate their teen daughter against HPV were 48.2 percentage points more likely to be fully vaccinated. Parents who reported being positively influenced to vaccinate against HPV were 28.9 percentage points more likely to report that their daughter's HCP talked about the HPV vaccine, 27.2 percentage points more likely to report that their daughter's HCP gave enough time to discuss the HPV shot, and 43.4 percentage points more likely to report that their daughter's HCP recommended the HPV vaccine (p<0.05). Among teen girls administered 1-2 doses of the HPV vaccine, 87.0% had missed opportunities for HPV vaccine administration. Conclusion Results suggest that an important pathway to achieving higher greater than or equal to 3 dose HPV vaccine coverage is by increasing HPV vaccination series initiation though HCP talking to parents about the HPV vaccine, giving parents time to discuss the vaccine, and by making a strong recommendation for the HPV. Also, HPV vaccination series completion rates may be increased by eliminating missed opportunities to vaccinate against HPV and scheduling additional follow-up visits to administer missing HPV vaccine doses. JF - Vaccine AU - Smith, Philip J AU - Stokley, Shannon AU - Bednarczyk, Robert A AU - Orenstein, Walter A AU - Omer, Saad B AD - Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Immunization Services Division, MS A-19, 1600 Clifton Road, NE, Atlanta, GA 30333, United States Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 1604 EP - 1610 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 13 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - HPV KW - Parental concerns KW - Provider influence KW - Attributable risk KW - Demography KW - Data processing KW - Health care KW - Vaccines KW - Vaccination KW - Immunization KW - Human papillomavirus KW - V 22350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773849347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=HPV+vaccination+coverage+of+teen+girls%3A+The+influence+of+health+care+providers&rft.au=Smith%2C+Philip+J%3BStokley%2C+Shannon%3BBednarczyk%2C+Robert+A%3BOrenstein%2C+Walter+A%3BOmer%2C+Saad+B&rft.aulast=Smith&rft.aufirst=Philip&rft.date=2016-03-01&rft.volume=34&rft.issue=13&rft.spage=1604&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2016.01.061 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 48 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Vaccines; Vaccination; Health care; Immunization; Human papillomavirus DO - http://dx.doi.org/10.1016/j.vaccine.2016.01.061 ER - TY - JOUR T1 - A simple procedure for estimating pseudo risk ratios from exposure to non-carcinogenic chemical mixtures. AN - 1765922383; 25667015 AB - Non-cancer risk assessment traditionally assumes a threshold of effect, below which there is a negligible risk of an adverse effect. The Agency for Toxic Substances and Disease Registry derives health-based guidance values known as Minimal Risk Levels (MRLs) as estimates of the toxicity threshold for non-carcinogens. Although the definition of an MRL, as well as EPA reference dose values (RfD and RfC), is a level that corresponds to "negligible risk," they represent daily exposure doses or concentrations, not risks. We present a new approach to calculate the risk at exposure to specific doses for chemical mixtures, the assumption in this approach is to assign de minimis risk at the MRL. The assigned risk enables the estimation of parameters in an exponential model, providing a complete dose-response curve for each compound from the chosen point of departure to zero. We estimated parameters for 27 chemicals. The value of k, which determines the shape of the dose-response curve, was moderately insensitive to the choice of the risk at the MRL. The approach presented here allows for the calculation of a risk from a single substance or the combined risk from multiple chemical exposures in a community. The methodology is applicable from point of departure data derived from quantal data, such as data from benchmark dose analyses or from data that can be transformed into probabilities, such as lowest-observed-adverse-effect level. The individual risks are used to calculate risk ratios that can facilitate comparison and cost-benefit analyses of environmental contamination control strategies. JF - Archives of toxicology AU - Scinicariello, Franco AU - Portier, Christopher AD - National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F57, Atlanta, GA, 30341, USA. fes6@cdc.gov. ; National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F57, Atlanta, GA, 30341, USA. cportier@mac.com. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 513 EP - 523 VL - 90 IS - 3 KW - Carcinogens KW - 0 KW - Complex Mixtures KW - Index Medicus KW - Risk assessment KW - Acceptable risk KW - Lowest-observed-adverse effect KW - Point of departure KW - Toxicological mixtures KW - Benchmark dose KW - Minimal Risk Levels KW - Probability KW - Reference Values KW - Humans KW - Carcinogens -- toxicity KW - Benchmarking KW - Models, Theoretical KW - Risk Assessment -- methods KW - Complex Mixtures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765922383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=A+simple+procedure+for+estimating+pseudo+risk+ratios+from+exposure+to+non-carcinogenic+chemical+mixtures.&rft.au=Scinicariello%2C+Franco%3BPortier%2C+Christopher&rft.aulast=Scinicariello&rft.aufirst=Franco&rft.date=2016-03-01&rft.volume=90&rft.issue=3&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-015-1467-z LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-02-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-015-1467-z ER - TY - JOUR T1 - Assessing arsenic exposure in households using bottled water or point-of-use treatment systems to mitigate well water contamination. AN - 1764342257; 26674699 AB - There is little published literature on the efficacy of strategies to reduce exposure to residential well water arsenic. The objectives of our study were to: 1) determine if water arsenic remained a significant exposure source in households using bottled water or point-of-use treatment systems; and 2) evaluate the major sources and routes of any remaining arsenic exposure. We conducted a cross-sectional study of 167 households in Maine using one of these two strategies to prevent exposure to arsenic. Most households included one adult and at least one child. Untreated well water arsenic concentrations ranged from <10 μg/L to 640 μg/L. Urine samples, water samples, daily diet and bathing diaries, and household dietary and water use habit surveys were collected. Generalized estimating equations were used to model the relationship between urinary arsenic and untreated well water arsenic concentration, while accounting for documented consumption of untreated water and dietary sources. If mitigation strategies were fully effective, there should be no relationship between urinary arsenic and well water arsenic. To the contrary, we found that untreated arsenic water concentration remained a significant (p ≤ 0.001) predictor of urinary arsenic levels. When untreated water arsenic concentrations were <40 μg/L, untreated water arsenic was no longer a significant predictor of urinary arsenic. Time spent bathing (alone or in combination with water arsenic concentration) was not associated with urinary arsenic. A predictive analysis of the average study participant suggested that when untreated water arsenic ranged from 100 to 500 μg/L, elimination of any untreated water use would result in an 8%-32% reduction in urinary arsenic for young children, and a 14%-59% reduction for adults. These results demonstrate the importance of complying with a point-of-use or bottled water exposure reduction strategy. However, there remained unexplained, water-related routes of exposure. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Smith, Andrew E AU - Lincoln, Rebecca A AU - Paulu, Chris AU - Simones, Thomas L AU - Caldwell, Kathleen L AU - Jones, Robert L AU - Backer, Lorraine C AD - Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. Electronic address: Andy.E.Smith@maine.gov. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA; University of Southern Maine, Muskie School of Public Service, PO Box 9300, Portland, ME 04104-9300, USA. ; Centers for Disease Control and Prevention, National Center for Environmental Health, Inorganic and Radiation Analytical Toxicology Branch, 4770 Buford Highway NE, MS F-18, Chamblee, GA 30341, USA. ; Centers for Disease Control and Prevention, National Center for Environmental Health, Health Studies Branch, 4770 Buford Highway NE, MS F-60, Chamblee, GA 30341, USA. Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 701 EP - 710 VL - 544 KW - Drinking Water KW - 0 KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Bottled water KW - Bathing KW - Well water KW - Point-of-use KW - Children KW - Family Characteristics KW - Environmental Monitoring KW - Humans KW - Water Purification KW - Maine KW - Arsenic -- analysis KW - Water Wells KW - Water Pollutants, Chemical -- analysis KW - Environmental Exposure -- statistics & numerical data KW - Drinking Water -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1764342257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Assessing+arsenic+exposure+in+households+using+bottled+water+or+point-of-use+treatment+systems+to+mitigate+well+water+contamination.&rft.au=Smith%2C+Andrew+E%3BLincoln%2C+Rebecca+A%3BPaulu%2C+Chris%3BSimones%2C+Thomas+L%3BCaldwell%2C+Kathleen+L%3BJones%2C+Robert+L%3BBacker%2C+Lorraine+C&rft.aulast=Smith&rft.aufirst=Andrew&rft.date=2016-02-15&rft.volume=544&rft.issue=&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.11.136 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-02-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Res. 2011 Jan;111(1):110-8 [21093857] Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60 [22143778] J Contam Hydrol. 2008 Jul 29;99(1-4):8-21 [18571283] J Health Popul Nutr. 2006 Sep;24(3):298-304 [17366771] Environ Health Perspect. 2005 Feb;113(2):192-200 [15687057] J Nutr. 1994 Nov;124(11 Suppl):2245S-2317S [7965210] Am J Epidemiol. 1991 Nov 15;134(10):1233-44 [1746532] Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Toxicol Lett. 2002 Jul 7;133(1):77-82 [12076512] Stat Med. 2000 Dec 15;19(23):3171-91 [11113952] Sci Total Environ. 2015 Feb 1;505:1282-90 [24726512] Sci Total Environ. 2015 Feb 1;505:1274-81 [24875279] J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):156-62 [23860400] Anal Bioanal Chem. 2009 Feb;393(3):939-47 [19082583] J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):182-90 [21878987] Environ Health Perspect. 2012 Oct;120(10):1418-24 [23008276] Environ Health Perspect. 2013 Mar;121(3):295-302 [23458756] J Expo Sci Environ Epidemiol. 2013 Jul;23(4):442-9 [23321855] Environ Health Perspect. 2013 Jul;121(7):818-24 [23694900] Sci Total Environ. 2015 Feb 1;505:1361-9 [24975493] PLoS One. 2014;9(9):e108098 [25251890] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.11.136 ER - TY - JOUR T1 - Vital Signs: Alcohol-Exposed Pregnancies--United States, 2011-2013. AN - 1762968643; 26845520 AB - Alcohol is a teratogen.* Prenatal alcohol exposure is associated with a range of adverse reproductive outcomes and can cause fetal alcohol spectrum disorders (FASDs) characterized by lifelong physical, behavioral, and intellectual disabilities. FASDs are completely preventable if a woman does not drink alcohol while pregnant. CDC analyzed data from the 2011-2013 National Survey of Family Growth to generate U.S. prevalence estimates of risk for an alcohol-exposed pregnancy for 4,303 nonpregnant, nonsterile women aged 15-44 years, by selected demographic and behavioral factors. A woman was considered at risk for an alcohol-exposed pregnancy during the past month if she had sex with a male, drank any alcohol, and did not (and her partner did not with her) use contraception in the past month; was not sterile; and had a partner (or partners) not known to be sterile. The weighted prevalence of alcohol-exposed pregnancy risk among U.S. women aged 15-44 years was 7.3%. During a 1-month period, approximately 3.3 million women in the United States were at risk for an alcohol-exposed pregnancy. Alcohol use in pregnancy is associated with low birthweight, preterm birth, birth defects, and developmental disabilities. Women of reproductive age should be informed of the risks of alcohol use during pregnancy, and contraception should be recommended, as appropriate, for women who do not want to become pregnant. Women wanting a pregnancy should be advised to stop drinking at the same time contraception is discontinued. Health care providers should advise women not to drink at all if they are pregnant or there is any chance they might be pregnant. Alcohol misuse screening and behavioral counseling (also known as alcohol screening and brief intervention) is recommended for all adults in primary care, including reproductive-aged and pregnant women, as an evidenced-based approach to reducing alcohol consumption among persons who consume alcohol in excess of the recommended guidelines. JF - MMWR. Morbidity and mortality weekly report AU - Green, Patricia P AU - McKnight-Eily, Lela R AU - Tan, Cheryl H AU - Mejia, Roberto AU - Denny, Clark H AD - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, CDC. Y1 - 2016/02/05/ PY - 2016 DA - 2016 Feb 05 SP - 91 EP - 97 VL - 65 IS - 4 KW - Index Medicus KW - Young Adult KW - Risk KW - Humans KW - Adult KW - Adolescent KW - United States -- epidemiology KW - Female KW - Prevalence KW - Pregnancy KW - Alcohol Drinking -- epidemiology KW - Fetal Alcohol Spectrum Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762968643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+mortality+weekly+report&rft.atitle=Vital+Signs%3A+Alcohol-Exposed+Pregnancies--United+States%2C+2011-2013.&rft.au=Green%2C+Patricia+P%3BMcKnight-Eily%2C+Lela+R%3BTan%2C+Cheryl+H%3BMejia%2C+Roberto%3BDenny%2C+Clark+H&rft.aulast=Green&rft.aufirst=Patricia&rft.date=2016-02-05&rft.volume=65&rft.issue=4&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+mortality+weekly+report&rft.issn=1545-861X&rft_id=info:doi/10.15585%2Fmmwr.mm6504a6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-07 N1 - Date created - 2016-02-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.15585/mmwr.mm6504a6 ER - TY - JOUR T1 - A Novel Botulinum Neurotoxin, Previously Reported as Serotype H, Has a Hybrid-Like Structure With Regions of Similarity to the Structures of Serotypes A and F and Is Neutralized With Serotype A Antitoxin AN - 1773835196; PQ0002694574 AB - Botulism is a potentially fatal paralytic disease caused by the action of botulinum neurotoxin (BoNT) on nerve cells. There are 7 known serotypes (A-G) of BoNT and up to 40 genetic variants. Clostridium botulinum strain IBCA10-7060 was recently reported to produce BoNT serotype B (BoNT/B) and a novel BoNT, designated as BoNT/H. The BoNT gene (bont) sequence of BoNT/H was compared to known bont sequences. Genetic analysis suggested that BoNT/H has a hybrid-like structure containing regions of similarity to the structures of BoNT/A1 and BoNT/F5. This novel BoNT was serologically characterized by the mouse neutralization assay and a neuronal cell-based assay. The toxic effects of this hybrid-like BoNT were completely eliminated by existing serotype A antitoxins, including those contained in multivalent therapeutic antitoxin products that are the mainstay of human botulism treatment. JF - Journal of Infectious Diseases AU - Maslanka, Susan E AU - Luquez, Carolina AU - Dykes, Janet K AU - Tepp, William H AU - Pier, Christina L AU - Pellett, Sabine AU - Raphael, Brian H AU - Kalb, Suzanne R AU - Barr, John R AU - Rao, Agam AU - Johnson, Eric A AD - Centers for Disease Control and Prevention, Atlanta, Georgia, smaslanka@cdc.gov Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 379 EP - 385 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 3 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts KW - botulinum toxin KW - Clostridium botulinum KW - serotype KW - botulism KW - neutralization KW - neuronal cell-based assay KW - Antitoxins KW - Infectious diseases KW - Toxicity KW - Neurotoxins KW - Food contamination KW - Neutralization KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773835196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Novel+Botulinum+Neurotoxin%2C+Previously+Reported+as+Serotype+H%2C+Has+a+Hybrid-Like+Structure+With+Regions+of+Similarity+to+the+Structures+of+Serotypes+A+and+F+and+Is+Neutralized+With+Serotype+A+Antitoxin&rft.au=Maslanka%2C+Susan+E%3BLuquez%2C+Carolina%3BDykes%2C+Janet+K%3BTepp%2C+William+H%3BPier%2C+Christina+L%3BPellett%2C+Sabine%3BRaphael%2C+Brian+H%3BKalb%2C+Suzanne+R%3BBarr%2C+John+R%3BRao%2C+Agam%3BJohnson%2C+Eric+A&rft.aulast=Maslanka&rft.aufirst=Susan&rft.date=2016-02-01&rft.volume=213&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Antitoxins; Infectious diseases; Toxicity; Food contamination; Neurotoxins; Neutralization; Clostridium botulinum DO - http://dx.doi.org/10.1093/infdis/jiv327 ER - TY - JOUR T1 - Determination of Evolutionary Relationships of Outbreak-Associated Listeria monocytogenes Strains of Serotypes 1/2a and 1/2b by Whole-Genome Sequencing AN - 1765986131; PQ0002637597 AB - We used whole-genome sequencing to determine evolutionary relationships among 20 outbreak-associated clinical isolates of Listeria monocytogenes serotypes 1/2a and 1/2b. Isolates from 6 of 11 outbreaks fell outside the clonal groups or "epidemic clones" that have been previously associated with outbreaks, suggesting that epidemic potential may be widespread in L. monocytogenes and is not limited to the recognized epidemic clones. Pairwise comparisons between epidemiologically related isolates within clonal complexes showed that genome-level variation differed by 2 orders of magnitude between different comparisons, and the distribution of point mutations (core versus accessory genome) also varied. In addition, genetic divergence between one closely related pair of isolates from a single outbreak was driven primarily by changes in phage regions. The evolutionary analysis showed that the changes could be attributed to horizontal gene transfer; members of the diverse bacterial community found in the production facility could have served as the source of novel genetic material at some point in the production chain. The results raise the question of how to best utilize information contained within the accessory genome in outbreak investigations. The full magnitude and complexity of genetic changes revealed by genome sequencing could not be discerned from traditional subtyping methods, and the results demonstrate the challenges of interpreting genetic variation among isolates recovered from a single outbreak. Epidemiological information remains critical for proper interpretation of nucleotide and structural diversity among isolates recovered during outbreaks and will remain so until we understand more about how various population histories influence genetic variation. JF - Antimicrobial Agents & Chemotherapy AU - Bergholz, Teresa M AU - den Bakker, Henk C AU - Katz, Lee S AU - Silk, Benjamin J AU - Jackson, Kelly A AU - Kucerova, Zuzana AU - Joseph, Lavin A AU - Turnsek, Maryann AU - Gladney, Lori M AU - Halpin, Jessica L AD - << + $0, ctarr@cdc.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 928 EP - 938 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 3 SN - 0099-2240, 0099-2240 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Clinical isolates KW - Phages KW - Listeria monocytogenes KW - Epidemics KW - Serotypes KW - Point mutation KW - Genetic diversity KW - Nucleotides KW - Population genetics KW - Gene transfer KW - Information processing KW - Evolution KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765986131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Determination+of+Evolutionary+Relationships+of+Outbreak-Associated+Listeria+monocytogenes+Strains+of+Serotypes+1%2F2a+and+1%2F2b+by+Whole-Genome+Sequencing&rft.au=Bergholz%2C+Teresa+M%3Bden+Bakker%2C+Henk+C%3BKatz%2C+Lee+S%3BSilk%2C+Benjamin+J%3BJackson%2C+Kelly+A%3BKucerova%2C+Zuzana%3BJoseph%2C+Lavin+A%3BTurnsek%2C+Maryann%3BGladney%2C+Lori+M%3BHalpin%2C+Jessica+L&rft.aulast=Bergholz&rft.aufirst=Teresa&rft.date=2016-02-01&rft.volume=82&rft.issue=3&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02440-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 54 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Phages; Clinical isolates; Genomes; Population genetics; Serotypes; Epidemics; Gene transfer; Information processing; Point mutation; Genetic diversity; Nucleotides; Evolution; Listeria monocytogenes DO - http://dx.doi.org/10.1128/AEM.02440-15 ER - TY - JOUR T1 - Arsenic and Gallium Arsenide Exposure Levels and Workers' Health Conditions in an Enterprise AN - 1780507149; PQ0002837803 AB - The objective of this paper is to evaluate workers' exposure to arsenic and gallium arsenide and health conditions in a gallium arsenide processing enterprise. Following the Specifications of Air Sampling for Hazardous Substances Monitoring in the Workplace (GBZ 159-2004), 147 arsenic and gallium arsenide air samples in 29 sampling points were collected. Occupational health examinations were conducted according to the Technical Specifications for Occupational Health Surveillance (GBZ 188-2007), and surveys included medical history, occupational history, and family history of diseases. SPSS 17.0 software was applied to analyze the workplace monitoring results and 327 workers' occupational health examination results through chi-square test and rank sum test In the enterprise investigated, most workers are exposed to low concentrations of arsenic and show skin damage and ALT abnormalities, and only a small part of workers performing specific tasks are exposed to relative high concentrations of arsenic. Therefore, the enterprise should pay attention to the health conditions of workers on key positions and high fluoride. JF - Huanjing yu Zhiye Yixue(Journal of Environmental & Occupational Medicine AU - Li, Qiu-hong AD - Department of Occupational Health, Tongzhou District Center for Disease Control and Prevention Y1 - 2016/01/25/ PY - 2016 DA - 2016 Jan 25 SP - 13 EP - 17 PB - Shanghai Shi Jibing Fangkongzhi Zhongxin, 1326 Yan'an Rd. Shanghai, 2000052 China VL - 33 IS - 1 SN - 2095-9982, 2095-9982 KW - Health & Safety Science Abstracts KW - arsenic KW - gallium arsenide KW - working environment KW - occupational exposure KW - health effect KW - Historical account KW - Genetics KW - Computer programs KW - Arsenic KW - Gallium KW - Skin KW - Fluoride KW - Air sampling KW - Occupational exposure KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780507149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Huanjing+yu+Zhiye+Yixue%28Journal+of+Environmental+%26+Occupational+Medicine&rft.atitle=Arsenic+and+Gallium+Arsenide+Exposure+Levels+and+Workers%27+Health+Conditions+in+an+Enterprise&rft.au=Li%2C+Qiu-hong&rft.aulast=Li&rft.aufirst=Qiu-hong&rft.date=2016-01-25&rft.volume=33&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Huanjing+yu+Zhiye+Yixue%28Journal+of+Environmental+%26+Occupational+Medicine&rft.issn=20959982&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Computer programs; Genetics; Historical account; Arsenic; Skin; Gallium; Fluoride; Air sampling; Occupational exposure; Occupational health ER - TY - JOUR T1 - Seroprevalence of 9 Human Papillomavirus Types in the United States, 2005-2006 AN - 1773839233; PQ0002694557 AB - Background. A 9-valent human papillomavirus (HPV) vaccine, licensed in 2014, prevents 4 HPV types targeted by the quadrivalent vaccine (6/11/16/18) and 5 additional high-risk (HR) types (31/33/45/52/58). Measuring seropositivity before vaccine introduction provides baseline data on exposure to types targeted by vaccines. Methods. We determined seroprevalence of HPV 6/11/16/18/31/33/45/52/58 among 4943 persons aged 14-59 years who participated in the National Health and Nutrition Examination Survey, 2005-2006. Results. Among females, seroprevalence was 40.5% for any of the 9 vaccine types, 30.0% for any 7 HR types (16/18/31/33/45/52/58), 19.0% for any 5 additional types (31/33/45/52/58), and 18.3% for 16/18. Compared with non-Hispanic whites, non-Hispanic blacks had higher seroprevalence of 31/33/45/52/58 (36.8% vs 15.9%) and 16/18 (30.1% vs 17.8%), while Mexican Americans had higher seroprevalence of 31/33/45/52/58 (23.6% vs 15.9%) (P or =1 of 9 HPV types. Seroprevalence of all type categories, especially HPV 31/33/45/52/58 among females, varied by race/ethnicity. JF - Journal of Infectious Diseases AU - Liu, Gui AU - Markowitz, Lauri E AU - Hariri, Susan AU - Panicker, Gitika AU - Unger, Elizabeth R AD - Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, wrf8@cdc.gov Y1 - 2016/01/15/ PY - 2016 DA - 2016 Jan 15 SP - 191 EP - 198 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 2 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - human papillomavirus KW - seroprevalence KW - racial differences KW - Age KW - Data processing KW - Nutrition KW - USA KW - Infectious diseases KW - Risk groups KW - Vaccines KW - Races KW - Ethnic groups KW - Human papillomavirus KW - Sex KW - V 22490:Miscellaneous KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773839233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Seroprevalence+of+9+Human+Papillomavirus+Types+in+the+United+States%2C+2005-2006&rft.au=Liu%2C+Gui%3BMarkowitz%2C+Lauri+E%3BHariri%2C+Susan%3BPanicker%2C+Gitika%3BUnger%2C+Elizabeth+R&rft.aulast=Liu&rft.aufirst=Gui&rft.date=2016-01-15&rft.volume=213&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv403 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Risk groups; Vaccines; Nutrition; Ethnic groups; Races; Sex; Infectious diseases; Human papillomavirus; USA DO - http://dx.doi.org/10.1093/infdis/jiv403 ER - TY - JOUR T1 - A Fatal Case Report on Occupational Subacute Dimethylformamide Poisoning AN - 1859472294; PQ0003969502 AB - In order to better prevent and treat dimethylformamide (DMF) poisoning and to provide cases on individual sensitivity to DMF and interpersonal variation,a special fatal DMF poisoning case who operated three roll mills in the grinding workshop of a color paste plant was reported and analyzed. The poisoning case might be sensitive to dimethylformamide. DMF individual sensitivity needs further study. JF - Huanjing yu Zhiye Yixue(Journal of Environmental & Occupational Medicine AU - Zheng, Shuang-lai AD - Public Health Surveillance Department , Hangzhou City Yuhang District Center for Disease Control and Prevention, Hangzhou, Zhejiang 311100 Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 1005 EP - 1007 PB - Shanghai Shi Jibing Fangkongzhi Zhongxin, 1326 Yan'an Rd. Shanghai, 2000052 China VL - 33 IS - 10 SN - 2095-9982, 2095-9982 KW - Health & Safety Science Abstracts KW - occupational KW - dimethylformamide KW - poisoning KW - death UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859472294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Q+Fever+is+Underestimated+in+the+United+States%3A+A+Comparison+of+Fatal+Q+Fever+Cases+from+Two+National+Reporting+Systems&rft.au=Dahlgren%2C+F+Scott%3BHaberling%2C+Dana+L%3BMcQuiston%2C+Jennifer+H&rft.aulast=Dahlgren&rft.aufirst=F&rft.date=2015-02-01&rft.volume=92&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.13213/j.cnki.jeom.2016.16190 ER - TY - JOUR T1 - Drug resistance and failure of virus inhibition after antiviral therapy among injecting drug users with HIV/AIDS AN - 1850769278; PQ0003905074 AB - Objective To understand the failure of virus inhibition and drug resistance among injecting drug users(IDU)with HIV/AIDS after antiretroviral therapy(ART)in China. Methods Data of basic demographic characteristics,ART information,CD4+cell count,viral load and drug resistance among IDUs with HIV/AIDS were retrieved from the Chinese HIV Drug Resistance(HIV DR)Monitoring Network,factors of viral inhibition failure and drug-resistance were evaluated. Results A total of 1 395 IDUs with HIV/AIDS were included in our study and the average ART month was 23.9.298(21.4%)subjects failed on the virus inhibition(VL> or =1 000copies/ml).The overall drug resistance rate was 8.4%(117/1 395)with 65.0%to NRTIs,69.2% to NNRTIs and 7.7% to PIs.Multivariate logistic regression analysis showed that the higher rates of virus inhibition failure occurred among IDUs with HIV/AIDS who were ethnic minorities(AOR=2.1,95% CI:1.6-2.9),recently received ART containing LPV/r(AOR=3.6,95% CI:2.4-5.4),did not take medicine in the most recent month(AOR=2.0,95% CI:1.4-3.0),started ART in 2011-2013(AOR=2.2,95% CI:1.5-3.2).While,IDUs aged over 35years(AOR=0.7,95% CI:0.6-1.0),were from Guangxi and Yunnan provinces(AOR=0.3,95% CI:0.2-0.5)had lower failure rate of virus inhibition. Conclusions The overall failure rate of virus inhibition among IDUs with HIV/AIDS remains in a higher level after ART,but it is relatively lower among those in Guangxi and Yunnan.The major influencing factor is found to be medication compliance. JF - Chinese Journal of Viral Diseases (Zhongguo Bingdubing Zazhi) AU - Teng, Tao AU - Leng, Xue-bing AU - Liang, Shu-jia AU - Ma, Yan-ling AU - Sun, Zhe-ya AU - Xu, Wei AU - Liao, Ling-jie AU - Xing, Hui AU - Ruan, Yu-hua AU - Shao, Yi-ming AD - State Key Laboratory for Infectious Disease Prevention and Control,National Center for AIDS/STD Control and Prevention,Chinese Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 PB - Periodical Editorial Department of Chinese Preventive Medicine Association, 154 Gulouxida Street, Xicheng District Beijing 100009 China VL - 6 IS - 2 SN - 2095-0136, 2095-0136 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Antiretroviral therapy KW - IDUs KW - HIV/AIDS KW - Virus inhibition failure KW - Drug resistance KW - Adherence KW - Demography KW - Acquired immune deficiency syndrome KW - Data processing KW - Lentivirus KW - Antiviral agents KW - Retroviridae KW - antiretroviral therapy KW - Regression analysis KW - Drug abuse KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850769278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Viral+Diseases+%28Zhongguo+Bingdubing+Zazhi%29&rft.atitle=Drug+resistance+and+failure+of+virus+inhibition+after+antiviral+therapy+among+injecting+drug+users+with+HIV%2FAIDS&rft.au=Teng%2C+Tao%3BLeng%2C+Xue-bing%3BLiang%2C+Shu-jia%3BMa%2C+Yan-ling%3BSun%2C+Zhe-ya%3BXu%2C+Wei%3BLiao%2C+Ling-jie%3BXing%2C+Hui%3BRuan%2C+Yu-hua%3BShao%2C+Yi-ming&rft.aulast=Teng&rft.aufirst=Tao&rft.date=2016-01-01&rft.volume=6&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Viral+Diseases+%28Zhongguo+Bingdubing+Zazhi%29&rft.issn=20950136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Demography; Acquired immune deficiency syndrome; Data processing; Antiviral agents; Drug resistance; antiretroviral therapy; Regression analysis; Drug abuse; Lentivirus; Retroviridae ER - TY - JOUR T1 - Association between gut microbiota of maternal obesity and children obesity AN - 1837307185; PQ0003808028 AB - With the rising of its incidence rate around the world,gestational obesity has become a public health problem affecting human health.The gut microbiota dysbiosis of obesity mother leads to abnormal colonization of infant at early stage,and the latter is closely related to the growth and development of infant in the future.Dysbiosis of gut microbiota is liable to cause adult diseases such as obesity,insulin resistance and metabolic syndrome et al.Hence,analyses of gut microbiota of obese pregnant women and infants,as well as the growth and development of babies,are of great significances for pregnancy management,health education and improvement of national physical quality. JF - Chinese Journal of Microecology AU - Zhang, Ye AU - Sui, Xuelin AU - Liu, Chengcheng AU - Yuan, Jieli AU - Guo, Yanjie AD - Center for Disease Control and Prevention of Shahekou District Dalian Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 1107 EP - 1109 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 9 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Obesity KW - Pregnant woman KW - Infant KW - Gut microbiota KW - Colonization KW - Digestive tract KW - Metabolic disorders KW - Children KW - Pregnancy KW - Infants KW - Public health KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837307185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Association+between+gut+microbiota+of+maternal+obesity+and+children+obesity&rft.au=Zhang%2C+Ye%3BSui%2C+Xuelin%3BLiu%2C+Chengcheng%3BYuan%2C+Jieli%3BGuo%2C+Yanjie&rft.aulast=Zhang&rft.aufirst=Ye&rft.date=2016-01-01&rft.volume=28&rft.issue=9&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Colonization; Obesity; Digestive tract; Metabolic disorders; Children; Public health; Infants; Pregnancy ER - TY - JOUR T1 - Characteristics of complete genome of an Oseltamivir-resistant influenza A(H1N1) pdm09 virus AN - 1837300878; PQ0003807972 AB - Objective To analyze the complete genetic characteristics of an Oseltamivir-resistant influenza A(H1N1)pdm09virus in order to provide a basis for treatment and prevention.Methods The viral RNA was extracted form chicken embryo culture inoculated with throat swab,and genome fragments were amplified by RT-PCR.The PCR products were sequenced and the complete genome sequence was obtained and analyzed via bioinformatics.Results Eight genome fragments of A/Fuzhou/SWL11609/2013(H1N1)were part of viruses cluster(2013-2014)and were closely related to those of A/California/07/2009(H1N1)vaccine strain,with the homologies> or = 97.4%.Nevertheless,its HA and NA genes were similar to the A/Hubei-Wuchang/SWL1322/2013(H1N1)(Oseltamivir-resistant influenza virus),with a similarity of100.0% and 99.6% respectively.Phylogenetic analysis showed initially that genetic reassortment had not occurred in the virus,neither had mutations at key pathogenic sites,so the virus strain was a low-pathogenic influenza virus.The H275 Ysubstitution was a typical feature of Oseltamivir-resistant genetic mutation.The N386 Ksubstitution resulted in the loss of a glycosylation site in the NA protein,which reduced the stability of gene structure in the presence of the V241 Iand N369Ksubstitutions,causing a negative effect on virus fitness.Conclusion The A/Fuzhou/SWL11609/2013(H1N1)virus was a low-pathogenic influenza virus,but still had the capability of human-to-human transmission,so more attention should be paid to the surveillance in order to control the increasing risk of wide spreading of Oseltamivir-resistant influenza virus. JF - Chinese Journal of Microecology AU - Xie, Jianfeng AU - Zhang, Yanhua AU - Zhao, Lin AU - Xiu, Wenqiong AU - Chen, Hongbin AU - Weng, Yuwei AU - Zheng, Kuicheng AD - Fujian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 884 EP - 888 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 8 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Influenza A(H1N1)pdm09 virus KW - Oseltamivir-resistant KW - Genetic characteristics KW - Genomes KW - Spreading KW - Pharynx KW - Nucleotide sequence KW - Glycosylation KW - Orthomyxoviridae KW - Influenza KW - Homology KW - RNA KW - Polymerase chain reaction KW - Embryos KW - Mutation KW - V 22410:Animal Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837300878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Characteristics+of+complete+genome+of+an+Oseltamivir-resistant+influenza+A%28H1N1%29+pdm09+virus&rft.au=Xie%2C+Jianfeng%3BZhang%2C+Yanhua%3BZhao%2C+Lin%3BXiu%2C+Wenqiong%3BChen%2C+Hongbin%3BWeng%2C+Yuwei%3BZheng%2C+Kuicheng&rft.aulast=Xie&rft.aufirst=Jianfeng&rft.date=2016-01-01&rft.volume=28&rft.issue=8&rft.spage=884&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Genomes; Influenza; Pharynx; Spreading; RNA; Homology; Nucleotide sequence; Polymerase chain reaction; Embryos; Glycosylation; Mutation; Orthomyxoviridae ER - TY - JOUR T1 - Detection and homological analysis of metallo- beta -lactamase genes,intI gene and ISCR1 in carbapenem-resistant Pseudomonas aeruginosa AN - 1827920011; PQ0003672900 AB - Objective To investigate the distribution of metallo-beta-lactamase,integron I and ISCR1,and analyze the characteristics of gene polymorphism in carbapenem resistant Pseudomonas aeruginosain Dalian.Methods 89 strains of clinical isolates of imipenem resistant Pseudomonas aeruginosa were collected.PCR was used to detect the resistant genes of metallo enzyme,integron I and ISCR1.Bacterial genotypes were detected by using Pulsed field gel electrophoresis(PFGE).Results Of the 89 strains of imipenem resistant Pseudomonas aeruginosa,25 strains carried ISCR1gene(25/89,28%),21isolates(21/25,84%)of which were multi-drug-resistant while 16 isolates were resistant to 5or more kinds of drugs.11 strains carried metallo-beta-lactamase gene(11/89,12%),8strains of which carried IMP-1gene and 3strains carried VIM-2gene.43 strains were integron I positive(43/89,48%).Strains carrying metallo-beta-lactamase gene were integron I negative and ISCR1 negative.PFGE showed 15 distinct PFGE genotypes(A-O),including 46 strains of type A,16 strains of type B,4strains of type C,5strains of type D,4strains of type E,3strains of type F,2strains of type G,2strains of type H,and 1strain each from type I to type O.Genotypes A to G were isolated from different hospitals and presented polymorphism; there were clones of each genotype.Conclusion The integron I and ISCR1 genes widely distributed among Pseudomonas aeruginosa in Dalian,which significantly correlated with bacterial multidrug resistance and extensively drug-resistance,especially the ISCR1 gene.The strains carrying integron I and ISCR1 did not carry metallo-beta-lactamase gene cassettes.Pseudomonas aeruginosain Dalian present genetic polymorphism,but there was dominant genotype. JF - Chinese Journal of Microecology AU - Wan, Qiang AU - Lyu, Qiuyue AU - Chen, Yang AD - Dalian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 786 EP - 790 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 7 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Carbapenem-resistant Pseudomonas aeruginosa KW - Integron KW - ISCR1 KW - PFGE KW - Clinical isolates KW - Gene polymorphism KW - Carbapenems KW - Multidrug resistance KW - Pseudomonas aeruginosa KW - Imipenem KW - Hospitals KW - J 02400:Human Diseases KW - A 01350:Microbial Resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827920011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Detection+and+homological+analysis+of+metallo-+beta+-lactamase+genes%2CintI+gene+and+ISCR1+in+carbapenem-resistant+Pseudomonas+aeruginosa&rft.au=Wan%2C+Qiang%3BLyu%2C+Qiuyue%3BChen%2C+Yang&rft.aulast=Wan&rft.aufirst=Qiang&rft.date=2016-01-01&rft.volume=28&rft.issue=7&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Gene polymorphism; Carbapenems; Multidrug resistance; Hospitals; Imipenem; Pseudomonas aeruginosa ER - TY - JOUR T1 - Virological characterization of influenza-like illness in Yuxi during 2009-2014 AN - 1808741479; PQ0003354823 AB - Objective To understand the epidemiologic characteristics of influenza and the changes of epidemic strains in Yuxi,and provide scientific basis for the disease control and prevention.Methods MDCK cells were used to culture the viruses,and the final influenza viruses were identified with influenza typing reagent.Results Among the total 3,248 cases monitored from 2009 to 2014,there were 489 positive specimens; the positive rate was 15.06%.New H1N1,H3N2 and influenza B accounted for 43.97%,28.22% and25.36%,respectively.Students and retirees accounted for 52.15% and 14.11% of the positive cases,respectively.The positive rate of influenza-like specimens from sentinel hospitals was significantly lower than that from flu outbreaks([chi]2=301.14,P<0.01).The peak flu season ran from October to March annually,with the predominant virus being new H1N1 from October 2009 to March 2011,influenza B from April2011 to March 2012,H3N2 from April 2012 to March 2013,and influenza B from April 2013 to March2014,respectively.Conclusion New H1N1,H3N2 and influenza B are the predominant virulent strains in Yuxi,which changed four times during 2009 and 2014,and may possibly keep changing in future.Therefore,it is necessary to strengthen the etiological monitoring of influenza-like cases and epidemic surveillance in priority crowds. JF - Chinese Journal of Microecology AU - Yang, Ru-song AU - Liu, Hong-yan AU - Ni, Zhao-lin AU - Zuo, Shun-wu AU - Wu, Qiang AU - Wang, Shu-kun AD - Center for Disease Control and Prevention of Yuxi Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 267 EP - 270 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 3 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Influenza KW - Influenza virus KW - Epidemiology KW - Prevention KW - Influenza B KW - Epidemics KW - Typing KW - Disease control KW - Cell culture KW - Hospitals KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808741479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Virological+characterization+of+influenza-like+illness+in+Yuxi+during+2009-2014&rft.au=Yang%2C+Ru-song%3BLiu%2C+Hong-yan%3BNi%2C+Zhao-lin%3BZuo%2C+Shun-wu%3BWu%2C+Qiang%3BWang%2C+Shu-kun&rft.aulast=Yang&rft.aufirst=Ru-song&rft.date=2016-01-01&rft.volume=28&rft.issue=3&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Influenza; Influenza B; Typing; Epidemics; Disease control; Cell culture; Hospitals ER - TY - JOUR T1 - Detection of Metallo-[beta]-lactamase gene and antibiotics resistance of Imipenem-resistant Pseudomonas aeruginosain Dalian area AN - 1808739472; PQ0003354858 AB - Objective To investigate the drug resistance of Carbapenem-resistant Pseudomonas aeruginosa(PA)in Dalian area,and provide reference for the prevention and control of nosocomial infections.Methods 400 clinical isolates of Pseudomonas aeruginosa were collected from four tertiary hospitals in Dalian during January 2013 to September 2014; Identification of isolates and antimicrobial susceptibility testing were performed.E-test(IPM/EDTA)method was used to detect MBL phenotype; PCR was applied to detect MBL genes(IMP-K,IMP-2,VIM-1,VIM-2,GIM,SPM,SIM and NDM).Results The 400 Pseudomonas aeruginosa were mainly isolated from respiratory tract secretion,accounting for 81.5%,most of which were from respiratory department(19.8%)and ICU ward(25.5%).89 strains were resistant to Imipenem and most of them were multidrug-resistant.17 strains of Imipenem-resistant isolates were MBL positive,accounting for 19.1%(17/89),while most of Imipenem sensitive strains were MBL negative.PCR amplification showed that 11 strains of Imipenem-resistant isolates carried MBL genes,among which 8strains carried IMP-1gene and 3strains carried VIM-2gene.IMP-2,VIM-1,GIM,SPM,SIM and NDM genes were not found.Conclusion The Imipenem-resistant PA in Dalian area are often multidrug resistant; The genes producing metallo-[beta]-lactamase and metallo-[beta]-lactamase are one of the main mechanisms of drug resistance of Pseudomonas aeruginosa to Imipenem,and the main genotypes are IMP-1and VIM-2. JF - Chinese Journal of Microecology AU - Wan, Qiang AU - Bo, Zhi-jian AU - Chen, Yang AD - Dalian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 405 EP - 408 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 4 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Pseudomonas aeruginosa KW - Drug-resistance KW - Metallo-[beta]-lactamase KW - Clinical isolates KW - Drug resistance KW - Genotypes KW - Antibiotic resistance KW - Imipenem KW - Hospitals KW - Antimicrobial agents KW - Respiratory tract KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808739472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Detection+of+Metallo-%5Bbeta%5D-lactamase+gene+and+antibiotics+resistance+of+Imipenem-resistant+Pseudomonas+aeruginosain+Dalian+area&rft.au=Wan%2C+Qiang%3BBo%2C+Zhi-jian%3BChen%2C+Yang&rft.aulast=Wan&rft.aufirst=Qiang&rft.date=2016-01-01&rft.volume=28&rft.issue=4&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Drug resistance; Genotypes; Antibiotic resistance; Respiratory tract; Antimicrobial agents; Hospitals; Imipenem; Pseudomonas aeruginosa ER - TY - JOUR T1 - The expression of inflammatory cytokines mRNA in blood of child patients with enterovirus 71 infection AN - 1808739271; PQ0003354791 AB - Objective To investigate the expression of inflammatory cytokines in blood of child patients with enterovirus 71(EV71)infection.Methods The expressions of Tumor necrosis factor-[alpha](TNF-[alpha]),Interferon-[alpha](IFN-[alpha]),IFN-[b e ta],Interleukin6(IL-6),IL-8and IL-12 mRNA in blood of children with mild or severe EV71 infection and healthy children were detected by Real-time PCR.Results The expressions of IFN-[alpha],IL-6,IL-8and IL-12 mRNA in blood increased in children with EV71infection(28+ or -182.07 vs 5.5+ or -0.79; 30+ or -103.30 vs 6+ or -4.21; 34+ or -169.60 vs 6.2+ or -4.16; 33.33+ or -229.7 vs 2.6+ or -0.92).The expressions of IFN-[alpha]and IL-12 mRNA were significantly higher in children with severe infection than those with mild EV71infection(40+ or -275.86 vs 28+ or -182.07; 46.67+ or -46.04 vs 33.33+ or -229.7).There was no significant difference in the expressions of IL-6and IL-8mRNA between children with mild and severe EV71infection(30+ or -103.3 vs 32+ or -110.5; 34+ or -169.6 vs 36.67+ or -195.4).Conclusion IFN-[alpha],IL-6,IL-8and IL-12 involve in the process of resistance to EV71 infection.IFN-[alpha]and IL-12 may be the key factors that contribute to the development of severe infection with EV71. JF - Chinese Journal of Microecology AU - Luan, Ming-chun AU - An, Yu AU - Chen, Yu-feng AU - Bo, Zhi-jian AU - Lyu, Qiu-yue AU - Liu, Dan-hong AD - Dalian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 138 EP - 140 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 2 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Enterovirus 71 KW - Hand-foot-and-mouth disease KW - Cytokines KW - Interleukin 6 KW - Interleukin 12 KW - Blood KW - Enterovirus KW - Children KW - Infection KW - mRNA KW - Inflammation KW - A 01490:Miscellaneous KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808739271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=The+expression+of+inflammatory+cytokines+mRNA+in+blood+of+child+patients+with+enterovirus+71+infection&rft.au=Luan%2C+Ming-chun%3BAn%2C+Yu%3BChen%2C+Yu-feng%3BBo%2C+Zhi-jian%3BLyu%2C+Qiu-yue%3BLiu%2C+Dan-hong&rft.aulast=Luan&rft.aufirst=Ming-chun&rft.date=2016-01-01&rft.volume=28&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Blood; Interleukin 12; Infection; Children; Inflammation; mRNA; Enterovirus ER - TY - JOUR T1 - The drug resistance and molecular typing of S.typhoidstrains in Dalian in 2014 AN - 1808739196; PQ0003354856 AB - Objective To investigate the antibiotic resistance and molecular types of Salmonella typhi isolated in Dalian,establish the background information of molecular characteristics of Salmonella typhi,and provide scientific evidences for future prevention and control.Methods Broth dilution technique was used to test the sensitivity of 46 strains of Salmonella typhi to 8antibiotics.Pulsed field gel-electrophoresis(PFGE)was used for molecular typing and cluster analysis of the 46 strains.Results All 46 strains of Salmonella typhi were sensitive to nalidixic acid.The drug resistance rates of the 46 strains of Salmonella typhi were 4.35%to chloramphenicol and trimethoprim/sulfamethoxazole respectively,and 47.83% to gentamycin.A multiple drug resistant strain was found.The 46 isolates were classified into 30 types by PFGE and only 7strains were classified into the same type.Conclusion Some Salmonella typhi strains in Dalian are resistant to gentamycin.PFGE result revealed that they present a genetic polymorphism,and there exist dominant strains. JF - Chinese Journal of Microecology AU - Hou, Jun AU - Chen, Yu-feng AU - Luan, Ming-chun AU - Wang, Xiao-wei AU - Li, Bo-sheng AU - Sun, Mao-li AU - Yu, Lei AU - Bo, Zhi-jian AU - Li, Rui AD - Dalian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 396 EP - 399 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 4 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella typhi KW - Antimicrobial resistance KW - Pulsed field gel-electrophoresis KW - Trimethoprim KW - Chloramphenicol KW - Typing KW - Sulfamethoxazole KW - Drug resistance KW - Antibiotic resistance KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808739196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Vermiculite+Worker+Mortality%3A+Estimated+Effects+of+Occupational+Exposure+to+Libby+Amphibole&rft.au=Larson%2C+T+C%3BAntao%2C+V+C%3BBove%2C+F+J&rft.aulast=Larson&rft.aufirst=T&rft.date=2010-05-01&rft.volume=52&rft.issue=5&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0b013e3181dc6d45 LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Chloramphenicol; Trimethoprim; Typing; Sulfamethoxazole; Drug resistance; Antibiotic resistance; Salmonella typhi ER - TY - JOUR T1 - Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA: Bacteriology AN - 1808691839; PQ0003310975 AB - The effect of second-generation pneumococcal conjugate vaccines on invasive pneumococcal disease (IPD) strain distributions have not yet been well described. We analysed IPD isolates recovered from children aged 95% for PI-2 and combined PI-1 + PI-2). beta -Lactam susceptibility phenotypes correlated consistently with transpeptidase region sequence combinations of the three major penicillin-binding proteins (PBPs) determined through WGS analysis. Other major resistance features were predictable by DNA signatures from WGS analysis. Multilocus sequence data combined with PBP combinations identified progeny, serotype donors and recipient strains in serotype switch events. PCV13 decreased the frequency of all PCV13 serotype clones and concurrently decreased the frequency of strain subsets with resistance and/or adherence features conducive to successful carriage. Our results serve as a reference describing key features of current paediatric IPD strains in the USA after PCV13 implementation. JF - Clinical Microbiology and Infection AU - Metcalf, B J AU - Gertz, RE Jr AU - Gladstone, R A AU - Walker, H AU - Sherwood, L K AU - Jackson, D AU - Li, Z AU - Law, C AU - Hawkins, P A AU - Chochua, S AU - Sheth, M AU - Rayamajhi, N AU - Bentley, S D AU - Kim, L AU - Whitney, C G AU - McGee, L AU - Beall, B AD - Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Atlanta, GA, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 60.e9 EP - 60.e29 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 22 IS - 1 SN - 1198-743X, 1198-743X KW - Microbiology Abstracts B: Bacteriology KW - Antimicrobial susceptibility KW - clonal complexes KW - pneumococcal conjugate vaccines KW - serotype distributions KW - whole genome sequence KW - Genomes KW - Bacteria KW - Data processing KW - Serotypes KW - Pediatrics KW - Nucleotide sequence KW - Drug resistance KW - penicillin-binding protein KW - Genotypes KW - Children KW - Mass spectroscopy KW - Streptococcus pneumoniae KW - Combined vaccines KW - beta -Lactam antibiotics KW - Polymerase chain reaction KW - Progeny KW - Vaccines KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808691839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences&rft.atitle=Use+of+reservoir+simulation+and+in-mine+ventilation+measurements+to+estimate+coal+seam+properties&rft.au=Erdogan%2C+S+S%3BKaracan%2C+COe%3BOkandan%2C+E&rft.aulast=Erdogan&rft.aufirst=S&rft.date=2013-10-01&rft.volume=63&rft.issue=&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences&rft.issn=13651609&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 29 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Genomes; Serotypes; Data processing; Pediatrics; Drug resistance; Nucleotide sequence; penicillin-binding protein; Genotypes; Children; Mass spectroscopy; Combined vaccines; beta -Lactam antibiotics; Polymerase chain reaction; Progeny; Vaccines; Bacteria; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.cmi.2015.08.027 ER - TY - JOUR T1 - Investigation of HIV Incidence Rates in a High-Risk, High-Prevalence Kenyan Population AN - 1808685988; PQ0003418565 AB - Cost-effective HIV prevention programs should target persons at high risk of HIV acquisition. We conducted an observational HIV incidence cohort study in Kisumu, Kenya, where HIV prevalence is triple that of the national rate. We used referral and venue-sampling approaches to enroll HIV-negative persons for a 12-month observational cohort, August 2010 to September 2011, collected data using computer-assisted interviews, and performed HIV testing quarterly. Among 1292 eligible persons, 648 (50%) were excluded for HIV positivity and other reasons. Of the 644 enrollees, 52% were women who were significantly older than men (P < .01). In all, 7 persons seroconverted (incidence rate [IR] per 100 person-years = 1.11; 95% confidence interval [CI] 0.45-2.30), 6 were women; 5 (IR = 3.14; 95% CI 1.02-7.34) of whom were less than or equal to 25 years. Most new infections occurred in young women, an observation consistent with other findings in sub-Saharan Africa that women aged less than or equal to 25 years are an important population for HIV intervention trials in Africa. JF - Journal of the International Association of Providers of AIDS Care (JIAPAC) AU - Mdodo, Rennatus AU - Gust, Deborah AU - Otieno, Fredrick O AU - McLellan-Lemal, Eleanor AU - Chen, Robert T AU - LeBaron, Charles AU - Hardnett, Felicia AU - Turner, Kyle AU - Ndivo, Richard AU - Zeh, Clement AU - Samandari, Taraz AU - Mills, Lisa A AD - Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA, cax6@cdc.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 42 EP - 50 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 15 IS - 1 SN - 2325-9574, 2325-9574 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - clinical trials KW - HIV incidence KW - risk factors KW - Kenya KW - Acquired immune deficiency syndrome KW - Data processing KW - Intervention KW - Infection KW - Prevention KW - Human immunodeficiency virus KW - Kenya, Nyanza, Kisumu KW - Risk factors KW - Economics KW - Africa KW - Risk groups KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808685988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.atitle=Investigation+of+HIV+Incidence+Rates+in+a+High-Risk%2C+High-Prevalence+Kenyan+Population&rft.au=Mdodo%2C+Rennatus%3BGust%2C+Deborah%3BOtieno%2C+Fredrick+O%3BMcLellan-Lemal%2C+Eleanor%3BChen%2C+Robert+T%3BLeBaron%2C+Charles%3BHardnett%2C+Felicia%3BTurner%2C+Kyle%3BNdivo%2C+Richard%3BZeh%2C+Clement%3BSamandari%2C+Taraz%3BMills%2C+Lisa+A&rft.aulast=Mdodo&rft.aufirst=Rennatus&rft.date=2016-01-01&rft.volume=15&rft.issue=1&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.issn=23259574&rft_id=info:doi/10.1177%2F2325957413511667 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Data processing; Risk factors; Risk groups; Infection; Prevention; Acquired immune deficiency syndrome; Economics; Intervention; Human immunodeficiency virus; Kenya; Kenya, Nyanza, Kisumu; Africa DO - http://dx.doi.org/10.1177/2325957413511667 ER - TY - JOUR T1 - Analysis on the prevalence of malaria cases in Dalian from 2011-2014 AN - 1808676837; PQ0003354910 AB - Objective To analyze the epidemiological characteristics and laboratory test results of malaria cases reported in Dalian from 2011-2014,explore the current prevalence and trend of malaria,and provide references for malaria control strategy and monitoring means.Methods Microscopic examination,RDT and Nested-PCR were used to detect malaria cases.Nested-PCR was used for the identification of Plasmodium species.Epidemiological analysis was conducted.Results There were 50 cases of malaria reported and identified in Dalian from 2011 to 2014,with 12,16,10 and 12cases in 2011-2014 respectively.Four species of Plasmodia were detected,including P.falciparum,P.vivax,P.ovale and P.malariae,as well as an undetined Plasmodium,which accounted for 82.0%(41/50),6.0%(3/50),6.0%(3/50),2.0%(1/50)and 4.0%(2/50)respectively.All the cases were imported ones from Africa except one from Dandong and one from India.Construction workers(40.0%)and fishermen(34.0%)were the major infected populations.Conclusion The natural environment in Dalian is prone to the prevalence of plasmodium infection.It is very important to monitor the local and imported malaria cases in order to prevent malaria from transmission and prevalence. JF - Chinese Journal of Microecology AU - Chen, Yu-feng AU - Yu, Gang-yin AU - Hou, Jun AU - Xu, Dan AU - Zheng, Li-li AU - Ren, Yi-xin AU - Qin, Yuan-hua AU - Wang, Xiao-wei AU - Cui, Yu AD - Dalian Center for Disease Control and Prevention Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 601 EP - 605 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 28 IS - 5 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Malaria KW - epidemiology KW - laboratory test KW - Biological surveys KW - China, People's Rep., Liaoning Prov., Dandong KW - Human diseases KW - Disease transmission KW - Public health KW - Plasmodium KW - Tests KW - Africa KW - China, People's Rep., Liaoning Prov., Dalian KW - Plasmodia KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808676837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=Analysis+on+the+prevalence+of+malaria+cases+in+Dalian+from+2011-2014&rft.au=Chen%2C+Yu-feng%3BYu%2C+Gang-yin%3BHou%2C+Jun%3BXu%2C+Dan%3BZheng%2C+Li-li%3BRen%2C+Yi-xin%3BQin%2C+Yuan-hua%3BWang%2C+Xiao-wei%3BCui%2C+Yu&rft.aulast=Chen&rft.aufirst=Yu-feng&rft.date=2016-01-01&rft.volume=28&rft.issue=5&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Tests; Malaria; Public health; Plasmodia; Disease transmission; Plasmodium; China, People's Rep., Liaoning Prov., Dandong; Africa; China, People's Rep., Liaoning Prov., Dalian ER - TY - JOUR T1 - Malaria Parasitemia among Febrile Patients Seeking Clinical Care at an Outpatient Health Facility in an Urban Informal Settlement Area in Nairobi, Kenya AN - 1765975470; PQ0002580207 AB - Nairobi is considered a low-risk area for malaria transmission, but travel can influence transmission of malaria. We investigated the demographic characteristics and travel history of patients with documented fever and malaria in a study clinic in a population-based surveillance system over a 5-year period, January 1, 2007 to December 31, 2011. During the study period, 11,480 (68%) febrile patients had a microscopy test performed for malaria, of which 2,553 (22%) were positive. Malaria was detected year-round with peaks in January, May, and September. Children aged 5-14 years had the highest proportion (28%) of positive results followed by children aged 1-4 years (23%). Almost two-thirds of patients with malaria reported traveling outside Nairobi; 79% of these traveled to three counties in western Kenya. History of recent travel (i.e., in past month) was associated with malaria parasitemia (odds ratio: 10.0, 95% confidence interval: 9.0-11.0). Malaria parasitemia was frequently observed among febrile patients at a health facility in the urban slum of Kibera, Nairobi. The majority of patients had traveled to western Kenya. However, 34% reported no travel history, which raises the possibility of local malaria transmission in this densely populated, urban setting. These findings have important implications for malaria control in large Nairobi settlements. JF - American Journal of Tropical Medicine and Hygiene AU - Njuguna, Henry N AU - Montgomery, Joel M AU - Cosmas, Leonard AU - Wamola, Newton AU - Oundo, Joseph O AU - Desai, Meghna AU - Buff, Ann M AU - Breiman, Robert F AD - Kenya Medical Research Institute (KEMRI), Nairobi, Kenya, hnjuguna@cdc.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 122 EP - 127 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 94 IS - 1 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Travel KW - Historical account KW - Human diseases KW - Population density KW - Malaria KW - Disease transmission KW - Public health KW - Demography KW - Fever KW - Risk groups KW - Slums KW - Urban areas KW - Biological surveys KW - Kenya, Nairobi KW - Children KW - parasitemia KW - Microscopy KW - Hygiene KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765975470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Malaria+Parasitemia+among+Febrile+Patients+Seeking+Clinical+Care+at+an+Outpatient+Health+Facility+in+an+Urban+Informal+Settlement+Area+in+Nairobi%2C+Kenya&rft.au=Njuguna%2C+Henry+N%3BMontgomery%2C+Joel+M%3BCosmas%2C+Leonard%3BWamola%2C+Newton%3BOundo%2C+Joseph+O%3BDesai%2C+Meghna%3BBuff%2C+Ann+M%3BBreiman%2C+Robert+F&rft.aulast=Njuguna&rft.aufirst=Henry&rft.date=2016-01-01&rft.volume=119&rft.issue=7&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1002725 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Human diseases; Malaria; Hygiene; Public health; Fever; Demography; Travel; parasitemia; Microscopy; Risk groups; Children; Historical account; Population density; Slums; Urban areas; Disease transmission; Kenya, Nairobi DO - http://dx.doi.org/10.4269/ajtmh.15-0293 ER - TY - JOUR T1 - Epidemiology of Invasive Group A Streptococcal Disease in Alaska, 2001 to 2013 AN - 1762381002; PQ0002453139 AB - The Arctic Investigations Program (AIP) began surveillance for invasive group A streptococcal (GAS) infections in Alaska in 2000 as part of the invasive bacterial diseases population-based laboratory surveillance program. Between 2001 and 2013, there were 516 cases of GAS infection reported, for an overall annual incidence of 5.8 cases per 100,000 persons with 56 deaths (case fatality rate, 10.7%). Of the 516 confirmed cases of invasive GAS infection, 422 (82%) had isolates available for laboratory analysis. All isolates were susceptible to penicillin, cefotaxime, and levofloxacin. Resistance to tetracycline, erythromycin, and clindamycin was seen in 11% (n = 8), 5.8% (n = 20), and 1.2% (n = 4) of the isolates, respectively. A total of 51 emm types were identified, of which emm1 (11.1%) was the most prevalent, followed by emm82 (8.8%), emm49 (7.8%), emm12 and emm3 (6.6% each), emm89 (6.2%), emm108 (5.5%), emm28 (4.7%), emm92 (4%), and emm41 (3.8%). The five most common emm types accounted for 41% of isolates. The emm types in the proposed 26-valent and 30-valent vaccines accounted for 56% and 78% of all cases, respectively. GAS remains an important cause of invasive bacterial disease in Alaska. Continued surveillance of GAS infections will help improve understanding of the epidemiology of invasive disease, with an impact on disease control, notification of outbreaks, and vaccine development. JF - Journal of Clinical Microbiology AU - Rudolph, Karen AU - Bruce, Michael G AU - Bruden, Dana AU - Zulz, Tammy AU - Reasonover, Alisa AU - Hurlburt, Debby AU - Hennessy, Thomas Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 134 EP - 141 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 54 IS - 1 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Clindamycin KW - Cefotaxime KW - Epidemiology KW - Levofloxacin KW - Disease control KW - Vaccines KW - Infection KW - Tetracyclines KW - Erythromycin KW - Penicillin KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762381002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Epidemiology+of+Invasive+Group+A+Streptococcal+Disease+in+Alaska%2C+2001+to+2013&rft.au=Rudolph%2C+Karen%3BBruce%2C+Michael+G%3BBruden%2C+Dana%3BZulz%2C+Tammy%3BReasonover%2C+Alisa%3BHurlburt%2C+Debby%3BHennessy%2C+Thomas&rft.aulast=Rudolph&rft.aufirst=Karen&rft.date=2016-01-01&rft.volume=54&rft.issue=1&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02122-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 46 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Clindamycin; Cefotaxime; Epidemiology; Levofloxacin; Disease control; Vaccines; Erythromycin; Tetracyclines; Infection; Penicillin; Streptococcus DO - http://dx.doi.org/10.1128/JCM.02122-15 ER - TY - JOUR T1 - The utility of population-based surveys to describe the continuum of HIV services for key and general populations AN - 1762377821; PQ0002525285 AB - Monitoring the cascade or continuum of HIV services - ranging from outreach services to anti-retroviral treatment - has become increasingly important as the focus in prevention moves toward biomedical interventions, in particular, 'Treatment as Prevention.' The HIV continuum typically utilises clinic-based care and treatment monitoring data and helps identify gaps and inform programme improvements. This paper discusses the merits of a population-based survey-informed continuum of services. Surveys provide individual-level, population-based data by sampling persons both in and outside the continuum, which facilitate the estimation of population fractions, such as the proportion of people living with HIV in care, as well as the examination of determinants for being in or outside the continuum. Survey-informed cascades of services may especially benefit key populations at increased risk for HIV infection for who social marginalisation, criminalisation, and stigma result in barriers to access and retention in services, a low social visibility, mobility, and outreach-based services can compromise clinic-based monitoring. Adding CD4+ T-cell count and viral load measurements to such surveys may provide population-level information on viral load suppression, stage of disease, treatment needs, and population-level transmission potential. While routine clinic-based reporting will remain the mainstay of monitoring, a survey-informed service cascade can address some of its limitations and offer additional insights. JF - International Journal of STD & AIDS AU - Hladik, Wolfgang AU - Benech, Irene AU - Bateganya, Moses AU - Hakim, Avi J Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 5 EP - 12 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 1 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Continuum of HIV services KW - cascade of services KW - care and treatment KW - population-based surveys KW - key populations KW - HIV KW - AIDS KW - treatment KW - antiretroviral therapy KW - Acquired immune deficiency syndrome KW - Data processing KW - Mobility KW - Intervention KW - Infection KW - Stigma KW - Health risks KW - Prevention KW - CD4 antigen KW - Human immunodeficiency virus KW - Lymphocytes T KW - Visibility KW - Sampling KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762377821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=The+utility+of+population-based+surveys+to+describe+the+continuum+of+HIV+services+for+key+and+general+populations&rft.au=Hladik%2C+Wolfgang%3BBenech%2C+Irene%3BBateganya%2C+Moses%3BHakim%2C+Avi+J&rft.aulast=Hladik&rft.aufirst=Wolfgang&rft.date=2016-01-01&rft.volume=16&rft.issue=3&rft.spage=2391&rft.isbn=&rft.btitle=&rft.title=Molecules+%28Basel%2C+Switzerland%29&rft.issn=1420-3049&rft_id=info:doi/10.3390%2Fmolecules16032391 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 45 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Data processing; Mobility; Lymphocytes T; Sampling; Infection; Stigma; Health risks; Acquired immune deficiency syndrome; Prevention; Human immunodeficiency virus; Intervention; Visibility; Sexually transmitted diseases DO - http://dx.doi.org/10.1177/0956462415581728 ER - TY - JOUR T1 - Prior infection with influenza virus but not vaccination leaves a long-term immunological imprint that intensifies the protective efficacy of antigenically drifted vaccine strains AN - 1762377708; PQ0002518801 AB - The role of pre-existing immunity for influenza vaccine responses is of great importance for public health, and thus has been studied in various contexts, yet the impact of differential priming on vaccine responses in the midst of antigenic drift remains to be elucidated. To address this with antigenically related viruses, mice were first primed by either infection or immunization with A/Puerto Rico/8/34 (PR8) virus, then immunized with whole-inactivated A/Fort Monmouth/1/47 (FM1) virus. The ensuing vaccine responses and the protective efficacy of FM1 were superior in PR8 infection-primed mice compared to PR8 immunization-primed or unprimed mice. Increased FM1-specific Ab responses of PR8 infection-primed mice also broadened cross-reactivity against contemporary as well as antigenically more drifted strains. Further, prior infection heightened the protective efficacy of antigenically distant strains, such as A/Brisbane/59/2006 infection followed by immunization with split pandemic H1N1 vaccine (A/California/07/2009). Therefore, influenza infection is a significant priming event that intensifies future vaccine responses against drift strains. JF - Vaccine AU - Kim, Jin Hyang AU - Liepkalns, Justine AU - Reber, Adrian J AU - Lu, Xiuhua AU - Music, Nedzad AU - Jacob, Joshy AU - Sambhara, Suryaprakash AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 495 EP - 502 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 34 IS - 4 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - HA hemagglutinin KW - NA neuraminidase KW - HI hemagglutination inhibition KW - HAU hemagglutination unit KW - MN microneutralization KW - LD50 50% lethal dose KW - PFU plaque forming unit KW - Influenza virus KW - Infection KW - Antigenic drift KW - Vaccine efficacy KW - Pandemic H1N1 KW - Cross-reactivity KW - Viruses KW - Leaves KW - Mice KW - Immunity KW - Vaccination KW - Immunization KW - Public health KW - Influenza KW - Antibodies KW - pandemics KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Drift KW - INE, USA, California KW - Vaccines KW - Australia, Queensland, Brisbane KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762377708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Prior+infection+with+influenza+virus+but+not+vaccination+leaves+a+long-term+immunological+imprint+that+intensifies+the+protective+efficacy+of+antigenically+drifted+vaccine+strains&rft.au=Kim%2C+Jin+Hyang%3BLiepkalns%2C+Justine%3BReber%2C+Adrian+J%3BLu%2C+Xiuhua%3BMusic%2C+Nedzad%3BJacob%2C+Joshy%3BSambhara%2C+Suryaprakash&rft.aulast=Kim&rft.aufirst=Jin&rft.date=2016-01-01&rft.volume=93&rft.issue=6&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0467 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 35 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Influenza; pandemics; Antibodies; Antigenic drift; Cross-reactivity; Drift; Leaves; Immunity; Vaccines; Infection; Vaccination; Public health; Viruses; Mice; Immunization; Influenza virus; ASW, Caribbean Sea, Greater Antilles, Puerto Rico; INE, USA, California; Australia, Queensland, Brisbane DO - http://dx.doi.org/10.1016/j.vaccine.2015.11.077 ER - TY - JOUR T1 - The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus AN - 1762373859; PQ0002487443 AB - Brincidofovir (BCV) is the 3-hexadecyloxy-1-propanol (HDP) lipid conjugate of the acyclic nucleoside phosphonate cidofovir (CDV). BCV has established broad-spectrum activity against double-stranded DNA (dsDNA) viruses; however, its activity against RNA viruses has been less thoroughly evaluated. Here, we report that BCV inhibited infection of Ebola virus in multiple human cell lines. Unlike the mechanism of action for BCV against cytomegalovirus and other dsDNA viruses, phosphorylation of CDV to the diphosphate form appeared unnecessary. Instead, antiviral activity required the lipid moiety and in vitro activity against EBOV was observed for several HDP-nucleotide conjugates. JF - Antiviral Research AU - McMullan, Laura K AU - Flint, Mike AU - Dyall, Julie AU - Albarino, Cesar AU - Olinger, Gene G AU - Foster, Scott AU - Sethna, Phiroze AU - Hensley, Lisa E AU - Nichol, Stuart T AU - Lanier, ERandall AU - Spiropoulou, Christina F AD - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 71 EP - 78 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 125 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Ebola KW - Antiviral therapy KW - In vitro screen KW - Brincidofovir KW - Cidofovir KW - phosphonates KW - Phosphorylation KW - Lipids KW - nucleosides KW - Ebola virus KW - RNA viruses KW - Antiviral activity KW - Infection KW - Cytomegalovirus KW - DNA viruses KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762373859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Trends+in+Disease+and+Complications+of+Hepatitis+A+Virus+Infection+in+the+United+States%2C+1999-2011%3A+A+New+Concern+for+Adults&rft.au=Ly%2C+Kathleen+N%3BKlevens%2C+R+Monina&rft.aulast=Ly&rft.aufirst=Kathleen&rft.date=2015-07-15&rft.volume=212&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu834 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Cidofovir; phosphonates; Phosphorylation; Lipids; nucleosides; RNA viruses; Infection; Antiviral activity; DNA viruses; Ebola virus; Cytomegalovirus DO - http://dx.doi.org/10.1016/j.antiviral.2015.10.010 ER - TY - JOUR T1 - The CDC Injury Center's Response to the Growing Public Health Problem of Falls Among Older Adults AN - 1762364501; PQ0002485909 AB - Background . Older adult falls are a significant cause of morbidity and mortality in the United States. This leading cause of injury in adults aged 65 and older results in $35 billion in direct medical costs. Objective. To project the number of older adult falls by 2030 and the associated lifetime medical cost. A secondary objective is to review what clinicians can do to incorporate falls screening and prevention into their practice for community-dwelling older adults. Methods . Using the Centers for Disease Control and Prevention's Web-based Injury Statistics Query and Reporting System and the US Census Bureau data, the number of older adults in 2030, fatal falls, and medical costs associated with fall injuries was projected. In addition, evidence-based interventions that can be integrated into clinical practice were reviewed. Results . The number of older adult fatal falls is projected to reach 100000 per year by 2030 with an associated cost of $100 billion. By integrating screening for falls risk into clinical practice, reviewing and modifying medications, and recommending vitamin D supplementation, physicians can reduce future falls by nearly 25%. Conclusion . Falls in older adults will continue to rise substantially and become a significant cost to our health care system if we do not begin to focus on prevention in the clinical setting. JF - American Journal of Lifestyle Medicine AU - Houry, Debra AU - Florence, Curtis AU - Baldwin, Grant AU - Stevens, Judy AU - McClure, Rod AD - National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, Vjz7@cdc.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 74 EP - 77 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 10 IS - 1 SN - 1559-8276, 1559-8276 KW - Health & Safety Science Abstracts KW - falls KW - prevention KW - older adults KW - STEADI KW - Mortality KW - Injuries KW - Disease control KW - Intervention KW - Morbidity KW - Public health KW - USA KW - Prevention KW - Vitamin D KW - Health care KW - Reviews KW - Census KW - Drugs KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762364501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Lifestyle+Medicine&rft.atitle=The+CDC+Injury+Center%27s+Response+to+the+Growing+Public+Health+Problem+of+Falls+Among+Older+Adults&rft.au=Houry%2C+Debra%3BFlorence%2C+Curtis%3BBaldwin%2C+Grant%3BStevens%2C+Judy%3BMcClure%2C+Rod&rft.aulast=Houry&rft.aufirst=Debra&rft.date=2016-01-01&rft.volume=10&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Lifestyle+Medicine&rft.issn=15598276&rft_id=info:doi/10.1177%2F1559827615600137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 22 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Mortality; Prevention; Vitamin D; Health care; Injuries; Reviews; Disease control; Intervention; Census; Drugs; Morbidity; Public health; USA DO - http://dx.doi.org/10.1177/1559827615600137 ER - TY - JOUR T1 - Characterization of Bacterial Communities in Selected Smokeless Tobacco Products Using 16S rDNA Analysis. AN - 1760886079; 26784944 AB - The bacterial communities present in smokeless tobacco (ST) products have not previously reported. In this study, we used Next Generation Sequencing to study the bacteria present in U.S.-made dry snuff, moist snuff and Sudanese toombak. Sample diversity and taxonomic abundances were investigated in these products. A total of 33 bacterial families from four phyla, Actinobacteria, Firmicutes, Proteobacteria and Bacteroidetes, were identified. U.S.-produced dry snuff products contained a diverse distribution of all four phyla. Moist snuff products were dominated by Firmicutes. Toombak samples contained mainly Actinobacteria and Firmicutes (Aerococcaceae, Enterococcaceae, and Staphylococcaceae). The program PICRUSt (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States) was used to impute the prevalence of genes encoding selected bacterial toxins, antibiotic resistance genes and other pro-inflammatory molecules. PICRUSt also predicted the presence of specific nitrate reductase genes, whose products can contribute to the formation of carcinogenic nitrosamines. Characterization of microbial community abundances and their associated genomes gives us an indication of the presence or absence of pathways of interest and can be used as a foundation for further investigation into the unique microbiological and chemical environments of smokeless tobacco products. JF - PloS one AU - Tyx, Robert E AU - Stanfill, Stephen B AU - Keong, Lisa M AU - Rivera, Angel J AU - Satten, Glen A AU - Watson, Clifford H AD - Division of Laboratory Sciences at the Centers for Disease Control and Prevention, Atlanta, GA, United States of America. ; Division of Reproductive Health, Center for Disease Control and Prevention, Atlanta, GA, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 1 KW - Bacterial Toxins KW - 0 KW - DNA, Bacterial KW - DNA, Ribosomal KW - RNA, Ribosomal, 16S KW - Index Medicus KW - United States KW - Phylogeny KW - Bacterial Toxins -- genetics KW - Software KW - Drug Resistance, Bacterial KW - Metagenome KW - High-Throughput Nucleotide Sequencing KW - Bacteria -- genetics KW - RNA, Ribosomal, 16S -- analysis KW - Tobacco, Smokeless -- classification KW - Bacteria -- classification KW - DNA, Ribosomal -- analysis KW - DNA, Bacterial -- analysis KW - Tobacco, Smokeless -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760886079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Characterization+of+Bacterial+Communities+in+Selected+Smokeless+Tobacco+Products+Using+16S+rDNA+Analysis.&rft.au=Tyx%2C+Robert+E%3BStanfill%2C+Stephen+B%3BKeong%2C+Lisa+M%3BRivera%2C+Angel+J%3BSatten%2C+Glen+A%3BWatson%2C+Clifford+H&rft.aulast=Tyx&rft.aufirst=Robert&rft.date=2016-01-01&rft.volume=11&rft.issue=1&rft.spage=e0146939&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0146939 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-28 N1 - Date created - 2016-01-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Bacteriol. 1999 Nov;181(21):6573-84 [10542156] Nature. 2013 May 30;497(7451):647-51 [23665960] J Bacteriol. 2002 Mar;184(5):1314-23 [11844760] Clin Diagn Lab Immunol. 2002 Sep;9(5):1057-60 [12204959] J Bacteriol. 2003 Dec;185(24):7247-56 [14645286] Carcinogenesis. 1991 Jun;12(6):1115-8 [2044192] Mol Microbiol. 1994 May;12(4):579-86 [7934881] Arch Microbiol. 1996 Dec;166(6):361-7 [9082911] Nucleic Acids Res. 1999 Jan 1;27(1):29-34 [9847135] Oral Oncol. 1998 Nov;34(6):558-66 [9930371] Nucleic Acids Res. 2014 Jan;42(Database issue):D199-205 [24214961] Nucleic Acids Res. 2014 Jan;42(Database issue):D643-8 [24293649] Int J Food Microbiol. 2015 Nov 6;212:60-6 [25805616] J Agric Food Chem. 2015 Oct 21;63(41):9131-8 [26452144] J Bacteriol. 1999 Jun;181(12):3658-65 [10368138] Appl Environ Microbiol. 2007 Feb;73(3):825-37 [17142368] Appl Microbiol Biotechnol. 2007 Jun;75(3):633-45 [17318539] Appl Microbiol Biotechnol. 2007 Jun;75(4):889-97 [17347820] Nucleic Acids Res. 2007;35(21):7188-96 [17947321] Nicotine Tob Res. 2008 Nov;10(11):1645-52 [18988077] Nicotine Tob Res. 2008 Dec;10(12):1773-82 [19023828] Regul Toxicol Pharmacol. 2009 Mar;53(2):121-33 [19135498] Environ Health Perspect. 2010 Mar;118(3):351-6 [20064769] Int J Syst Evol Microbiol. 2010 Apr;60(Pt 4):874-9 [19661509] Nat Methods. 2010 May;7(5):335-6 [20383131] Appl Microbiol Biotechnol. 2010 Sep;88(2):553-62 [20645083] Tob Control. 2011 May;20(3):e2 [21109685] Nucleic Acids Res. 2000 Jan 1;28(1):27-30 [10592173] Appl Microbiol Biotechnol. 2011 Dec;92(5):1033-44 [21660545] Biochem Soc Trans. 2011 Dec;39(6):1838-43 [22103536] Nucleic Acids Res. 2012 Jan;40(Database issue):D115-22 [22194640] Food Chem Toxicol. 2012 Mar;50(3-4):942-8 [22142690] PLoS One. 2012;7(5):e36357 [22563494] Tob Control. 2012 Jul;21(4):396-401 [21642445] Regul Toxicol Pharmacol. 2012 Dec;64(3):367-87 [23000415] Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6 [23193283] Nucleic Acids Res. 2013 Jan 7;41(1):e1 [22933715] Food Chem Toxicol. 2013 Jul;57:380-6 [23517910] Nat Biotechnol. 2013 Sep;31(9):814-21 [23975157] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0146939 ER - TY - JOUR T1 - Increases in Drug and Opioid Overdose Deaths--United States, 2000-2014. AN - 1753007256; 26720857 AB - The United States is experiencing an epidemic of drug overdose (poisoning) deaths. Since 2000, the rate of deaths from drug overdoses has increased 137%, including a 200% increase in the rate of overdose deaths involving opioids (opioid pain relievers and heroin). CDC analyzed recent multiple cause-of-death mortality data to examine current trends and characteristics of drug overdose deaths, including the types of opioids associated with drug overdose deaths. During 2014, a total of 47,055 drug overdose deaths occurred in the United States, representing a 1-year increase of 6.5%, from 13.8 per 100,000 persons in 2013 to 14.7 per 100,000 persons in 2014. The rate of drug overdose deaths increased significantly for both sexes, persons aged 25-44 years and ≥55 years, non-Hispanic whites and non-Hispanic blacks, and in the Northeastern, Midwestern, and Southern regions of the United States. Rates of opioid overdose deaths also increased significantly, from 7.9 per 100,000 in 2013 to 9.0 per 100,000 in 2014, a 14% increase. Historically, CDC has programmatically characterized all opioid pain reliever deaths (natural and semisynthetic opioids, methadone, and other synthetic opioids) as "prescription" opioid overdoses (1). Between 2013 and 2014, the age-adjusted rate of death involving methadone remained unchanged; however, the age-adjusted rate of death involving natural and semisynthetic opioid pain relievers, heroin, and synthetic opioids, other than methadone (e.g., fentanyl) increased 9%, 26%, and 80%, respectively. The sharp increase in deaths involving synthetic opioids, other than methadone, in 2014 coincided with law enforcement reports of increased availability of illicitly manufactured fentanyl, a synthetic opioid; however, illicitly manufactured fentanyl cannot be distinguished from prescription fentanyl in death certificate data. These findings indicate that the opioid overdose epidemic is worsening. There is a need for continued action to prevent opioid abuse, dependence, and death, improve treatment capacity for opioid use disorders, and reduce the supply of illicit opioids, particularly heroin and illicit fentanyl. JF - MMWR. Morbidity and mortality weekly report AU - Rudd, Rose A AU - Aleshire, Noah AU - Zibbell, Jon E AU - Gladden, R Matthew AD - Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC. Y1 - 2016/01/01/ PY - 2016 DA - 2016 Jan 01 SP - 1378 EP - 1382 VL - 64 IS - 50-51 KW - Analgesics, Opioid KW - 0 KW - Index Medicus KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Infant, Newborn KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Child, Preschool KW - Analgesics, Opioid -- poisoning KW - Drug Overdose -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753007256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+mortality+weekly+report&rft.atitle=Increases+in+Drug+and+Opioid+Overdose+Deaths--United+States%2C+2000-2014.&rft.au=Rudd%2C+Rose+A%3BAleshire%2C+Noah%3BZibbell%2C+Jon+E%3BGladden%2C+R+Matthew&rft.aulast=Rudd&rft.aufirst=Rose&rft.date=2016-01-01&rft.volume=64&rft.issue=50-51&rft.spage=1378&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+mortality+weekly+report&rft.issn=1545-861X&rft_id=info:doi/10.15585%2Fmmwr.mm6450a3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-26 N1 - Date created - 2016-01-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.15585/mmwr.mm6450a3 ER - TY - JOUR T1 - Communitywide cryptosporidiosis outbreak associated with a surface water-supplied municipal water system - Baker City, Oregon, 2013 AN - 1751229127; PQ0002409331 AB - Cryptosporidium, a parasite known to cause large drinking and recreational water outbreaks, is tolerant of chlorine concentrations used for drinking water treatment. Human laboratory-based surveillance for enteric pathogens detected a cryptosporidiosis outbreak in Baker City, Oregon during July 2013 associated with municipal drinking water. Objectives of the investigation were to confirm the outbreak source and assess outbreak extent. The watershed was inspected and city water was tested for contamination. To determine the community attack rate, a standardized questionnaire was administered to randomly sampled households. Weighted attack rates and confidence intervals (CIs) were calculated. Water samples tested positive for Cryptosporidium species; a Cryptosporidium parvum subtype common in cattle was detected in human stool specimens. Cattle were observed grazing along watershed borders; cattle faeces were observed within watershed barriers. The city water treatment facility chlorinated, but did not filter, water. The community attack rate was 28.3% (95% CI 22.1-33.6), sickening an estimated 2780 persons. Watershed contamination by cattle probably caused this outbreak; water treatments effective against Cryptosporidium were not in place. This outbreak highlights vulnerability of drinking water systems to pathogen contamination and underscores the need for communities to invest in system improvements to maintain multiple barriers to drinking water contamination. JF - Epidemiology and Infection AU - DeSILVA, M B AU - Schafer, S AU - Kendall Scott, M AU - Robinson, B AU - Hills, A AU - Buser, G L AU - Salis, K AU - Gargano, J AU - Yoder, J AU - Hill, V AU - Xiao, L AU - Roellig, D AU - Hedberg, K AD - Epidemic Intelligence Service, Division of Scientific Education and Professional Development, Center for Surveillance, Epidemiology, and Laboratory Services, CDC, Atlanta, GA, USA, xdh8@cdc.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 274 EP - 284 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 144 IS - 2 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts KW - Water sampling KW - Grazing KW - Pathogens KW - Watersheds KW - Cryptosporidium parvum KW - INE, USA, Oregon KW - Cryptosporidiosis KW - Cattle KW - Water treatment KW - Households KW - Water-borne diseases KW - Standards KW - Vulnerability KW - Outbreaks KW - Drinking water KW - Urban areas KW - H 3000:Environment and Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751229127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Communitywide+cryptosporidiosis+outbreak+associated+with+a+surface+water-supplied+municipal+water+system+-+Baker+City%2C+Oregon%2C+2013&rft.au=DeSILVA%2C+M+B%3BSchafer%2C+S%3BKendall+Scott%2C+M%3BRobinson%2C+B%3BHills%2C+A%3BBuser%2C+G+L%3BSalis%2C+K%3BGargano%2C+J%3BYoder%2C+J%3BHill%2C+V%3BXiao%2C+L%3BRoellig%2C+D%3BHedberg%2C+K&rft.aulast=DeSILVA&rft.aufirst=M&rft.date=2016-01-01&rft.volume=144&rft.issue=2&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815001831 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 34 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Water sampling; Grazing; Pathogens; Watersheds; Cattle; Cryptosporidiosis; Water treatment; Households; Water-borne diseases; Standards; Outbreaks; Vulnerability; Drinking water; Urban areas; Cryptosporidium parvum; INE, USA, Oregon DO - http://dx.doi.org/10.1017/S0950268815001831 ER - TY - JOUR T1 - A case-control study of risk factors for death from 2009 pandemic influenza A(H1N1): is American Indian racial status an independent risk factor? AN - 1751228821; PQ0002409324 AB - Historically, American Indian/Alaska Native (AI/AN) populations have suffered excess morbidity and mortality from influenza. We investigated the risk factors for death from 2009 pandemic influenza A(H1N1) in persons residing in five states with substantial AI/AN populations. We conducted a case-control investigation using pandemic influenza fatalities from 2009 in Alaska, Arizona, New Mexico, Oklahoma and Wyoming. Controls were outpatients with influenza. We reviewed medical records and interviewed case proxies and controls. We used multiple imputation to predict missing data and multivariable conditional logistic regression to determine risk factors. We included 145 fatal cases and 236 controls; 22% of cases were AI/AN. Risk factors (P 45 years vs. <18 years], pre-existing medical conditions (mOR 7.1), smoking (mOR 3.0), delayed receipt of antivirals (mOR 6.5), and barriers to healthcare access (mOR 5.3). AI/AN race was not significantly associated with death. The increased influenza mortality in AI/AN individuals was due to factors other than racial status. Prevention of influenza deaths should focus on modifiable factors (smoking, early antiviral use, access to care) and identifying high-risk persons for immunization and prompt medical attention. JF - Epidemiology and Infection AU - Hennessy, T W AU - BRUDEN, D AU - Castrodale, L AU - Komatsu, K AU - Erhart, L M AU - Thompson, D AU - Bradley, K AU - O'Leary AU - McLAUGHLIN, J AU - Landen, M AD - Arctic Investigations Program, US Centers for Disease Control and Prevention (CDC), Anchorage, AK, USA, Tbh0@cdc.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 315 EP - 324 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 144 IS - 2 SN - 0950-2688, 0950-2688 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Age KW - Morbidity KW - USA, Oklahoma KW - Influenza KW - Smoking KW - pandemics KW - Risk factors KW - Geriatrics KW - Risk groups KW - Ethnic groups KW - Races KW - Mortality KW - USA, New Mexico KW - USA, Wyoming KW - Data processing KW - medical records KW - INE, USA, Alaska KW - Immunization KW - Prevention KW - Health care KW - Reviews KW - USA, Arizona KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751228821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=A+case-control+study+of+risk+factors+for+death+from+2009+pandemic+influenza+A%28H1N1%29%3A+is+American+Indian+racial+status+an+independent+risk+factor%3F&rft.au=Hennessy%2C+T+W%3BBRUDEN%2C+D%3BCastrodale%2C+L%3BKomatsu%2C+K%3BErhart%2C+L+M%3BThompson%2C+D%3BBradley%2C+K%3BO%27Leary%3BMcLAUGHLIN%2C+J%3BLanden%2C+M&rft.aulast=Hennessy&rft.aufirst=T&rft.date=2016-01-01&rft.volume=144&rft.issue=2&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815001211 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 32 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; medical records; Morbidity; Immunization; Influenza; Smoking; pandemics; Risk factors; Reviews; Geriatrics; Risk groups; Races; Historical account; Age; Prevention; Health care; Ethnic groups; USA, Oklahoma; USA, New Mexico; USA, Wyoming; USA, Arizona; INE, USA, Alaska DO - http://dx.doi.org/10.1017/S0950268815001211 ER - TY - JOUR T1 - Evaluating the effectiveness of state specific lead-based paint hazard risk reduction laws in preventing recurring incidences of lead poisoning in children. AN - 1735330787; 26472219 AB - Despite significant progress made in recent decades in preventing childhood lead poisoning in the United States through the control or elimination of lead sources in the environment, it continues to be an issue in many communities, primarily in low-income communities with a large percentage of deteriorating housing built before the elimination of lead in residential paint. The purpose of this study is to determine whether state laws aimed at preventing childhood lead poisoning are also effective in preventing recurring lead poisoning among children previously poisoned. An evaluation was conducted to determine whether laws in two representative states, Massachusetts and Ohio, have been effective in preventing recurrent lead poisoning among children less than 72 months of age previously poisoned, compared to a representative state (Mississippi) which at the time of the study had yet to develop legislation to prevent childhood lead poisoning. Compared to no legislation, unadjusted estimates showed children less than 72 months old, living in Massachusetts, previously identified as being lead poisoned, were 73% less likely to develop recurrent lead poisoning. However, this statistically significant association did not remain after controlling for other confounding variables. We did not find such a significant association when analyzing data from Ohio. While findings from unadjusted estimates indicated that state lead laws such as those in Massachusetts may be effective at preventing recurrent lead poisoning among young children, small numbers may have attenuated the power to obtain statistical significance during multivariate analysis. Our findings did not provide evidence that state lead laws, such as those in Ohio, were effective in preventing recurrent lead poisoning among young children. Further studies may be needed to confirm these findings. Published by Elsevier GmbH. JF - International journal of hygiene and environmental health AU - Kennedy, Chinaro AU - Lordo, Robert AU - Sucosky, Marissa Scalia AU - Boehm, Rona AU - Brown, Mary Jean AD - Centers for Disease Control and Prevention, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. Electronic address: gjn5@cdc.gov. ; Battelle Memorial Institute, Columbus, OH, USA. ; Centers for Disease Control and Prevention, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 110 EP - 117 VL - 219 IS - 1 KW - Hazardous Substances KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Lead law KW - Blood lead levels KW - Childhood lead poisoning KW - Housing KW - Humans KW - Child KW - Recurrence KW - Child, Preschool KW - Infant KW - State Government KW - Risk Reduction Behavior KW - Massachusetts KW - Incidence KW - Female KW - Male KW - Ohio KW - Lead -- adverse effects KW - Lead Poisoning -- prevention & control KW - Government Regulation KW - Paint KW - Environmental Exposure -- legislation & jurisprudence KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735330787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Evaluating+the+effectiveness+of+state+specific+lead-based+paint+hazard+risk+reduction+laws+in+preventing+recurring+incidences+of+lead+poisoning+in+children.&rft.au=Kennedy%2C+Chinaro%3BLordo%2C+Robert%3BSucosky%2C+Marissa+Scalia%3BBoehm%2C+Rona%3BBrown%2C+Mary+Jean&rft.aulast=Kennedy&rft.aufirst=Chinaro&rft.date=2016-01-01&rft.volume=219&rft.issue=1&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=1618-131X&rft_id=info:doi/10.1016%2Fj.ijheh.2015.09.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-01 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijheh.2015.09.009 ER - TY - JOUR T1 - Reduction in Human Papillomavirus Vaccine Type Prevalence Among Young Women Screened for Cervical Cancer in an Integrated US Healthcare Delivery System in 2007 and 2012-2013 AN - 1780527252; PQ0002879753 AB - Background. In the United States, human papillomavirus (HPV) vaccine is recommended for 11- or 12-year-olds, and for young adults not previously vaccinated. Early vaccine impact can be measured by reductions in vaccine-type (VT) HPV prevalence. Methods. Consecutive residual cervical specimens were retained from women aged 20-29 years at Kaiser Permanente Northwest in 2007, 2012, and 2013. HPV genotypes were determined using L1 consensus polymerase chain reaction with type-specific hybridization to detect 37 types, including VT HPV (HPV type 6, 11, 16, and 18). We compared HPV prevalence in 2007 and 2012-2013, and we evaluated predictors of VT HPV and any-HPV prevalence in 2012-2013. Results. In 2012-2013, 31.9% of 4181 women had initiated HPV vaccination. VT HPV prevalence decreased from 10.6% in 2007 to 6.2% in 2012-2013 (P < .001). In 2012-2013, VT HPV prevalence was significantly lower among those who initiated vaccination <19 years (adjusted prevalence ratio, 0.1; 95% confidence interval, .1-.3) than among those who were not vaccinated, and higher among those who had chlamydia, human immunodeficiency virus, or pregnancy testing in the past year than among those who did not (adjusted prevalence ratio, 1.4; 95% confidence interval, 1.1-1.8). Conclusions. Reduction in VT HPV was found in young women in an integrated healthcare delivery system within 6 years of vaccine introduction, indicating early HPV vaccine impact. JF - Journal of Infectious Diseases AU - Dunne, Eileen F AU - Naleway, Allison AU - Smith, Ning AU - Crane, Bradley AU - Weinmann, Sheila AU - Braxton, Jim AU - Steinau, Martin AU - Unger, Elizabeth R AU - Markowitz, Lauri E AD - Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 1970 EP - 1975 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 12 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - impact KW - HPV KW - HPV type prevalence KW - vaccine KW - Cervical cancer KW - Genotypes KW - Vaccination KW - Cancer KW - Pregnancy KW - USA KW - Health care KW - Infectious diseases KW - Human immunodeficiency virus KW - Polymerase chain reaction KW - Females KW - Young adults KW - Vaccines KW - Cervix KW - Sexually transmitted diseases KW - Chlamydia KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780527252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Reduction+in+Human+Papillomavirus+Vaccine+Type+Prevalence+Among+Young+Women+Screened+for+Cervical+Cancer+in+an+Integrated+US+Healthcare+Delivery+System+in+2007+and+2012-2013&rft.au=Dunne%2C+Eileen+F%3BNaleway%2C+Allison%3BSmith%2C+Ning%3BCrane%2C+Bradley%3BWeinmann%2C+Sheila%3BBraxton%2C+Jim%3BSteinau%2C+Martin%3BUnger%2C+Elizabeth+R%3BMarkowitz%2C+Lauri+E&rft.aulast=Dunne&rft.aufirst=Eileen&rft.date=2015-12-15&rft.volume=212&rft.issue=12&rft.spage=1970&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv342 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Cervical cancer; Polymerase chain reaction; Genotypes; Vaccines; Cervix; Vaccination; Pregnancy; Infectious diseases; Health care; Human immunodeficiency virus; Young adults; Females; Cancer; Sexually transmitted diseases; Human papillomavirus; Chlamydia; USA DO - http://dx.doi.org/10.1093/infdis/jiv342 ER - TY - JOUR T1 - A Newly Emerged Swine-Origin Influenza A(H3N2) Variant Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation AN - 1780498420; PQ0002879747 AB - We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts. JF - Journal of Infectious Diseases AU - Cao, Weiping AU - Mishina, Margarita AU - Ranjan, Priya AU - De La Cruz, Juan A AU - Kim, Jin Hyang AU - Garten, Rebecca AU - Kumar, Amrita AU - Garcia-Sastre, Adolfo AU - Katz, Jacqueline M AU - Gangappa, Shivaprakash AU - Sambhara, Suryaprakash AD - Immunology and Pathogenesis Branch, wcao@cdc.gov Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 1923 EP - 1929 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 12 SN - 0022-1899, 0022-1899 KW - Immunology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - A(H3N2)vpM KW - myeloid dendritic cell KW - proinflammatory cytokines KW - type I IFN KW - ROS KW - inflammasome activation KW - Viruses KW - M gene KW - Immunity KW - Infection KW - Inflammation KW - Cell activation KW - Influenza KW - Interferon KW - Dendritic cells KW - pandemics KW - Sulfur dioxide KW - Infectious diseases KW - Immune response KW - Seasonal variations KW - V 22350:Immunology KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780498420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=A+Newly+Emerged+Swine-Origin+Influenza+A%28H3N2%29+Variant+Dampens+Host+Antiviral+Immunity+but+Induces+Potent+Inflammasome+Activation&rft.au=Cao%2C+Weiping%3BMishina%2C+Margarita%3BRanjan%2C+Priya%3BDe+La+Cruz%2C+Juan+A%3BKim%2C+Jin+Hyang%3BGarten%2C+Rebecca%3BKumar%2C+Amrita%3BGarcia-Sastre%2C+Adolfo%3BKatz%2C+Jacqueline+M%3BGangappa%2C+Shivaprakash%3BSambhara%2C+Suryaprakash&rft.aulast=Cao&rft.aufirst=Weiping&rft.date=2015-12-15&rft.volume=212&rft.issue=12&rft.spage=1923&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv330 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Influenza; Dendritic cells; Interferon; pandemics; M gene; Immunity; Infection; Cell activation; Inflammation; Sulfur dioxide; Infectious diseases; Viruses; Immune response; Seasonal variations DO - http://dx.doi.org/10.1093/infdis/jiv330 ER - TY - JOUR T1 - In Vitro Efficacy of Antiviral Compounds against Enterovirus D68 AN - 1832245312; PQ0002380841 AB - In 2014, the United States experienced a large outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68). We used a homogeneous, cell-based assay to assess the antiviral activity of compounds developed for EV/rhinovirus infection or other indications. Three of 15 compounds were highly active against all four strains tested (the prototype and three 2014 strains), with 50% effective concentrations of 0.0012 to 0.027 mu M. Additional studies are needed to assess their in vivo efficacy against EV-D68. JF - Antimicrobial Agents & Chemotherapy AU - Rhoden, Eric AU - Zhang, Mingyu AU - Nix, W Allan AU - Oberste, M Steven AD - << + $0, soberste@cdc.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 7779 EP - 7781 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 12 SN - 0066-4804, 0066-4804 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Enterovirus KW - Picornaviridae KW - Antiviral activity KW - Infection KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832245312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Efficacy+of+Antiviral+Compounds+against+Enterovirus+D68&rft.au=Rhoden%2C+Eric%3BZhang%2C+Mingyu%3BNix%2C+W+Allan%3BOberste%2C+M+Steven&rft.aulast=Rhoden&rft.aufirst=Eric&rft.date=2015-12-01&rft.volume=59&rft.issue=12&rft.spage=7779&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.00766-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 30 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Infection; Antiviral activity; Enterovirus; Picornaviridae DO - http://dx.doi.org/10.1128/AAC.00766-15 ER - TY - JOUR T1 - Predictive Value of School-Aged Children's Schistosomiasis Prevalence and Egg Intensity for Other Age Groups in Western Kenya AN - 1787965170; PQ0002931885 AB - World Health Organization recommendations for the timing and target population for mass drug administration (MDA) for schistosomiasis are based on the prevalence of infection in school children within a given community. In a large study comparing MDA approaches for Schistosoma mansoni control, we evaluated whether prevalence of infection and egg burdens in 9- to 12-year-old students reflected infection levels in young children and adults in the same community. Cross-sectional surveys of preadolescents (9-12 years old) were compared with those of first year students (5-8 years old) in 225 villages and adults (20-55 years old) in 150 villages along the Kenyan shores of Lake Victoria. Village schistosomiasis prevalence and intensity levels in preadolescents strongly correlated (P< 0.0001) with prevalence and infection intensity for other age groups in the community. Our findings suggest that S. mansoni prevalence and intensity among 9- to 12-year-olds are valid for community sampling purposes in mapping for MDAs. JF - American Journal of Tropical Medicine and Hygiene AU - Mwinzi, Pauline N M AU - Muchiri, Geoffrey AU - Wiegand, Ryan E AU - Omedo, Martin AU - Abudho, Bernard AU - Karanja, Diana M S AU - Montgomery, Susan P AU - Secor, W Evan AD - Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya, was4@cdc.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1311 EP - 1317 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Schistosoma mansoni KW - Prediction KW - Parasites KW - Age KW - Organizations KW - Shores KW - Infection KW - Eggs KW - Public health KW - Lakes KW - Sampling KW - Mapping KW - Drugs KW - Schistosomiasis KW - Children KW - Education establishments KW - Africa, Victoria L. KW - Villages KW - Age groups KW - Hygiene KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - H 0500:General KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787965170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Predictive+Value+of+School-Aged+Children%27s+Schistosomiasis+Prevalence+and+Egg+Intensity+for+Other+Age+Groups+in+Western+Kenya&rft.au=Mwinzi%2C+Pauline+N+M%3BMuchiri%2C+Geoffrey%3BWiegand%2C+Ryan+E%3BOmedo%2C+Martin%3BAbudho%2C+Bernard%3BKaranja%2C+Diana+M+S%3BMontgomery%2C+Susan+P%3BSecor%2C+W+Evan&rft.aulast=Mwinzi&rft.aufirst=Pauline+N&rft.date=2015-12-01&rft.volume=93&rft.issue=6&rft.spage=1311&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0467 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Prediction; Parasites; Organizations; Schistosomiasis; Age groups; Hygiene; Education establishments; Eggs; Public health; Lakes; Age; Shores; Mapping; Sampling; Children; Infection; Drugs; Villages; Schistosoma mansoni; Africa, Victoria L. DO - http://dx.doi.org/10.4269/ajtmh.15-0467 ER - TY - JOUR T1 - A Review of Melioidosis Cases in the Americas AN - 1787961738; PQ0002931858 AB - Melioidosis is a bacterial infection caused by Burkholderia pseudomallei, a gram-negative saprophytic bacillus. Cases occur sporadically in the Americas with an increasing number of cases observed among people with no travel history to endemic countries. To better understand the incidence of the disease in the Americas, we reviewed the literature, including unpublished cases reported to the Centers for Disease Control and Prevention. Of 120 identified human cases, occurring between 1947 and June 2015, 95 cases (79%) were likely acquired in the Americas; the mortality rate was 39%. Burkholderia pseudomallei appears to be widespread in South, Central, and North America. JF - American Journal of Tropical Medicine and Hygiene AU - Benoit, Tina J AU - Blaney, David D AU - Doker, Thomas J AU - Gee, Jay E AU - Elrod, Mindy G AU - Rolim, Dionne B AU - Inglis, Timothy J J AU - Hoffmaster, Alex R AU - Bower, William A AU - Walke, Henry T AD - Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, dblaney@cdc.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1134 EP - 1139 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Burkholderia pseudomallei KW - Travel KW - North America KW - Historical account KW - Mortality KW - Melioidosis KW - Disease control KW - Infection KW - Prevention KW - Endemic species KW - Literature reviews KW - Reviews KW - Hygiene KW - Bacillus KW - Mortality causes KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - K 03400:Human Diseases KW - J 02400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787961738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=A+Review+of+Melioidosis+Cases+in+the+Americas&rft.au=Benoit%2C+Tina+J%3BBlaney%2C+David+D%3BDoker%2C+Thomas+J%3BGee%2C+Jay+E%3BElrod%2C+Mindy+G%3BRolim%2C+Dionne+B%3BInglis%2C+Timothy+J+J%3BHoffmaster%2C+Alex+R%3BBower%2C+William+A%3BWalke%2C+Henry+T&rft.aulast=Benoit&rft.aufirst=Tina&rft.date=2015-12-01&rft.volume=93&rft.issue=6&rft.spage=1134&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0405 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Endemic species; Literature reviews; Disease control; Hygiene; Mortality causes; Travel; Mortality; Reviews; Melioidosis; Infection; Historical account; Prevention; Burkholderia pseudomallei; Bacillus; North America DO - http://dx.doi.org/10.4269/ajtmh.15-0405 ER - TY - JOUR T1 - Effect of nitrite on the formation of halonitromethanes during chlorination of organic matter from different origin AN - 1784735502; 2016-035818 AB - Occurrence of halonitromethanes (HNMs) in drinking water has been a public concern due to the potential risks to human health. Though quite a lot of work has been carried out to understand the formation of HNMs, the relationship between HNMs formation and the nitrite remains unclear. In this study, the effects of nitrite on the formation of HNMs during chlorination of organic matter from different origin were assessed. Organic matter (OM) derived from phoenix tree (fallen leaves: FLOM; green leaves: GLOM) and Microcystis aeruginosa (intracellular organic matter: IOM) were used to mimic the allochthonous and autochthonous organic matter in surface water, respectively. Results showed that HNMs yields were significantly enhanced with the addition of nitrite, and the highest enhancement was observed for FLOM, successively followed by GLOM and IOM, suggesting that the contribution of nitrite to HNMs formation was positively related with SUVA (an indicator for aromaticity) of OM. Therefore, the nitrite contamination should be strictly controlled for the source water dominated by allochthonous OM, which may significantly reduce the formation of HNMs during chlorination. Moreover, given a certain nitrite level, the higher pH resulted in higher stimulation of HNM formation, yet the chlorine dose (always added in excess resulting in residual reactive chlorine), reaction time and temperature did not show obvious influence. Abstract Copyright (2015) Elsevier, B.V. JF - Journal of Hydrology AU - Hong, Huachang AU - Qian, Lingya AU - Xiao, Zhuoqun AU - Zhang, Jianqing AU - Chen, Jianrong AU - Lin, Hongjun AU - Yu, Haiying AU - Shen, Liguo AU - Liang, Yan Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 802 EP - 809 PB - Elsevier, Amsterdam VL - 531 IS - Part 3 SN - 0022-1694, 0022-1694 KW - chlorinated hydrocarbons KW - water quality KW - aliphatic hydrocarbons KW - vegetation KW - drinking water KW - environmental effects KW - statistical distribution KW - colorimetry KW - ultraviolet spectra KW - halogenated hydrocarbons KW - spectra KW - chemical composition KW - water pollution KW - nitrite ion KW - chemical analysis KW - methane KW - pollutants KW - biochemistry KW - physicochemical properties KW - pollution KW - alkanes KW - organic compounds KW - halonitromethane KW - hydrocarbons KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1784735502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hydrology&rft.atitle=Effect+of+nitrite+on+the+formation+of+halonitromethanes+during+chlorination+of+organic+matter+from+different+origin&rft.au=Hong%2C+Huachang%3BQian%2C+Lingya%3BXiao%2C+Zhuoqun%3BZhang%2C+Jianqing%3BChen%2C+Jianrong%3BLin%2C+Hongjun%3BYu%2C+Haiying%3BShen%2C+Liguo%3BLiang%2C+Yan&rft.aulast=Hong&rft.aufirst=Huachang&rft.date=2015-12-01&rft.volume=531&rft.issue=Part+3&rft.spage=802&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hydrology&rft.issn=00221694&rft_id=info:doi/10.1016%2Fj.jhydrol.2015.10.046 L2 - http://www.sciencedirect.com/science/journal/00221694 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 30 N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Includes appendices N1 - Last updated - 2016-04-28 N1 - CODEN - JHYDA7 N1 - SubjectsTermNotLitGenreText - aliphatic hydrocarbons; alkanes; biochemistry; chemical analysis; chemical composition; chlorinated hydrocarbons; colorimetry; drinking water; environmental effects; halogenated hydrocarbons; halonitromethane; hydrocarbons; methane; nitrite ion; organic compounds; physicochemical properties; pollutants; pollution; spectra; statistical distribution; ultraviolet spectra; vegetation; water pollution; water quality DO - http://dx.doi.org/10.1016/j.jhydrol.2015.10.046 ER - TY - JOUR T1 - Preventing community-wide transmission of Cryptosporidium: a proactive public health response to a swimming pool-associated outbreak - Auglaize County, Ohio, USA AN - 1762382822; PQ0002459167 AB - The incidence of recreational water-associated outbreaks in the United States has significantly increased, driven, at least in part, by outbreaks both caused by Cryptosporidium and associated with treated recreational water venues. Because of the parasite's extreme chlorine tolerance, transmission can occur even in well-maintained treated recreational water venues (e.g. pools) and a focal cryptosporidiosis outbreak can evolve into a community-wide outbreak associated with multiple recreational water venues and settings (e.g. childcare facilities). In August 2004 in Auglaize County, Ohio, multiple cryptosporidiosis cases were identified and anecdotally linked to pool A. Within 5 days of the first case being reported, pool A was hyperchlorinated to achieve 99.9% Cryptosporidium inactivition. A case-control study was launched to epidemiologically ascertain the outbreak source 11 days later. A total of 150 confirmed and probable cases were identified; the temporal distribution of illness onset was peaked, indicating a point-source exposure. Cryptosporidiosis was significantly associated with swimming in pool A (matched odds ratio 121.7, 95% confidence interval 27.4- infinity ) but not with another venue or setting. The findings of this investigation suggest that proactive implementation of control measures, when increased Cryptosporidium transmission is detected but before an outbreak source is epidemiologically ascertained, might prevent a focal cryptosporidiosis outbreak from evolving into a community-wide outbreak. JF - Epidemiology and Infection AU - Cope, J R AU - Prosser, A AU - Nowicki, S AU - Roberts, M W AU - Roberts, J M AU - Scheer, D AU - Anderson, C AU - Longsworth, A AU - Parsons, C AU - Goldschmidt, D AU - Johnston, S AU - Bishop, H AU - Xiao, L AU - Hill, V AU - Beach, M AU - Hlavsa, M C AD - Centres for Disease Control and Prevention, Atlanta, GA, USA, jcope@cdc.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 3459 EP - 3467 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 16 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts KW - Daycare KW - Swimming KW - Temporal distribution KW - Chlorine KW - Disease transmission KW - Public health KW - Cryptosporidiosis KW - Recreation areas KW - Cryptosporidium KW - Outbreaks KW - USA, Ohio KW - K 03400:Human Diseases KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762382822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Preventing+community-wide+transmission+of+Cryptosporidium%3A+a+proactive+public+health+response+to+a+swimming+pool-associated+outbreak+-+Auglaize+County%2C+Ohio%2C+USA&rft.au=Cope%2C+J+R%3BProsser%2C+A%3BNowicki%2C+S%3BRoberts%2C+M+W%3BRoberts%2C+J+M%3BScheer%2C+D%3BAnderson%2C+C%3BLongsworth%2C+A%3BParsons%2C+C%3BGoldschmidt%2C+D%3BJohnston%2C+S%3BBishop%2C+H%3BXiao%2C+L%3BHill%2C+V%3BBeach%2C+M%3BHlavsa%2C+M+C&rft.aulast=Cope&rft.aufirst=J&rft.date=2015-12-01&rft.volume=143&rft.issue=16&rft.spage=3459&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815000813 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 32 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Swimming; Cryptosporidiosis; Chlorine; Public health; Disease transmission; Daycare; Temporal distribution; Recreation areas; Outbreaks; Cryptosporidium; USA, Ohio DO - http://dx.doi.org/10.1017/S0950268815000813 ER - TY - JOUR T1 - A Mixed-Methods Assessment of a Brief Smoking Cessation Intervention Implemented in Ohio Public Health Clinics, 2013 AN - 1762362395; PQ0002364492 AB - In 2006, the state of Ohio initiated the implementation of a brief smoking cessation intervention (5As: Ask, Advise, Assess, Assist, and Arrange) in select public health clinics that serve low-income pregnant and post-partum women. Funds later became available to expand the program statewide by 2015. However, close to half of the clinics initially trained stopped implementation of the 5As. To help guide the proposed statewide expansion plan for implementation of the 5As, this study assessed barriers and facilitators related to 5As implementation among clinics that had ever received training. Methods: A mixed-methods approach was used, comprising semi-structured interviews with clinic program directors (n = 21) and a survey of clinic staff members (n = 120), to assess implementation-related barriers, facilitators, training needs, and staff confidence in delivering the 5As. Results: Semi-structured interviews of program directors elucidated implementation barriers including time constraints, low self-efficacy in engaging resistant clients, and paperwork-related documentation challenges. Facilitators included availability of community referral resources, and integration of cessation interventions into the clinic workflow. Program directors believed they would benefit from more hands-on training in delivering the 5As. The survey results showed that a majority of staff felt confident advising (61 %) or referring clients for tobacco dependence treatment (74 %), but fewer felt confident about discussing treatment options with clients (29 %) or providing support to clients who had relapsed (30 %). Conclusions: Time constraints and documentation issues were major barriers to implementing the 5As. Simplified documentation processes and training enhancements, coupled with systems change, may enhance delivery of evidence-based smoking cessation interventions. JF - Maternal and Child Health Journal AU - Agaku, Israel T AU - Olaiya, Oluwatosin AU - Quinn, Celia AU - Tong, Van T AU - Kuiper, Nicole M AU - Conrey, Elizabeth J AU - Sharma, Andrea J AU - Mullen, Sierra AU - Dee, Deborah AD - Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA, iagaku@cdc.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 2654 EP - 2662 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 19 IS - 12 SN - 1092-7875, 1092-7875 KW - Health & Safety Science Abstracts KW - Smoking KW - Funds KW - Training KW - Tobacco KW - Intervention KW - Socioeconomics KW - USA, Ohio KW - Public health KW - Pregnancy KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762362395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+Child+Health+Journal&rft.atitle=A+Mixed-Methods+Assessment+of+a+Brief+Smoking+Cessation+Intervention+Implemented+in+Ohio+Public+Health+Clinics%2C+2013&rft.au=Agaku%2C+Israel+T%3BOlaiya%2C+Oluwatosin%3BQuinn%2C+Celia%3BTong%2C+Van+T%3BKuiper%2C+Nicole+M%3BConrey%2C+Elizabeth+J%3BSharma%2C+Andrea+J%3BMullen%2C+Sierra%3BDee%2C+Deborah&rft.aulast=Agaku&rft.aufirst=Israel&rft.date=2015-12-01&rft.volume=19&rft.issue=12&rft.spage=2654&rft.isbn=&rft.btitle=&rft.title=Maternal+and+Child+Health+Journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-015-1786-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 24 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Smoking; Funds; Training; Tobacco; Socioeconomics; Intervention; Pregnancy; Public health; USA, Ohio DO - http://dx.doi.org/10.1007/s10995-015-1786-y ER - TY - JOUR T1 - In Vitro and Molecular Surveillance for Antimalarial Drug Resistance in Plasmodium falciparum Parasites in Western Kenya Reveals Sustained Artemisinin Sensitivity and Increased Chloroquine Sensitivity AN - 1758245004; PQ0002380925 AB - Malaria control is hindered by the evolution and spread of resistance to antimalarials, necessitating multiple changes to drug policies over time. A comprehensive antimalarial drug resistance surveillance program is vital for detecting the potential emergence of resistance to antimalarials, including current artemisinin-based combination therapies. An antimalarial drug resistance surveillance study involving 203 Plasmodium falciparum malaria-positive children was conducted in western Kenya between 2010 and 2013. Specimens from enrolled children were analyzed in vitro for sensitivity to chloroquine (CQ), amodiaquine (AQ), mefloquine (MQ), lumefantrine, and artemisinin derivatives (artesunate and dihydroartemisinin) and for drug resistance allele polymorphisms in P. falciparum crt (Pfcrt), Pfmdr-1, and the K13 propeller domain (K13). We observed a significant increase in the proportion of samples with the Pfcrt wild-type (CVMNK) genotype, from 61.2% in 2010 to 93.0% in 2013 (P < 0.0001), and higher proportions of parasites with elevated sensitivity to CQ in vitro. The majority of isolates harbored the wild-type N allele in Pfmdr-1 codon 86 (93.5%), with only 7 (3.50%) samples with the N86Y mutant allele (the mutant nucleotide is underlined). Likewise, most isolates harbored the wild-type Pfmdr-1 D1246 allele (79.8%), with only 12 (6.38%) specimens with the D1246Y mutant allele and 26 (13.8%) with mixed alleles. All the samples had a single copy of the Pfmdr-1 gene (mean of 0.907 plus or minus 0.141 copies). None of the sequenced parasites had mutations in K13. Our results suggest that artemisinin is likely to remain highly efficacious and that CQ sensitivity appears to be on the rise in western Kenya. JF - Antimicrobial Agents & Chemotherapy AU - Lucchi, Naomi W AU - Komino, Franklin AU - Okoth, Sheila Akinyi AU - Goldman, Ira AU - Onyona, Philip AU - Wiegand, Ryan E AU - Juma, Elizabeth AU - Shi, Ya Ping AU - Barnwell, John W AU - Udhayakumar, Venkatachalam AD - << + $0, NLucchi@cdc.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 7540 EP - 7547 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 12 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Parasites KW - Human diseases KW - Allelles KW - Drug resistance KW - Nucleotide sequence KW - Malaria KW - Public health KW - Kenya KW - Mefloquine KW - artesunate KW - Amodiaquine KW - Mutations KW - Chloroquine KW - Plasmodium falciparum KW - Children KW - Nucleotides KW - Codons KW - Dihydroartemisinin KW - artemisinin KW - Mutation KW - Evolution KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758245004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+and+Molecular+Surveillance+for+Antimalarial+Drug+Resistance+in+Plasmodium+falciparum+Parasites+in+Western+Kenya+Reveals+Sustained+Artemisinin+Sensitivity+and+Increased+Chloroquine+Sensitivity&rft.au=Lucchi%2C+Naomi+W%3BKomino%2C+Franklin%3BOkoth%2C+Sheila+Akinyi%3BGoldman%2C+Ira%3BOnyona%2C+Philip%3BWiegand%2C+Ryan+E%3BJuma%2C+Elizabeth%3BShi%2C+Ya+Ping%3BBarnwell%2C+John+W%3BUdhayakumar%2C+Venkatachalam&rft.aulast=Lucchi&rft.aufirst=Naomi&rft.date=2015-12-01&rft.volume=59&rft.issue=12&rft.spage=7540&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01894-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Number of references - 51 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Mutations; Allelles; Nucleotide sequence; Drug resistance; Malaria; Nucleotides; Public health; Amodiaquine; Chloroquine; Children; Codons; artemisinin; Dihydroartemisinin; Mefloquine; artesunate; Mutation; Evolution; Plasmodium falciparum; Kenya DO - http://dx.doi.org/10.1128/AAC.01894-15 ER - TY - JOUR T1 - Trends in Exposure to Chemicals in Personal Care and Consumer Products. AN - 1728258448; 26342608 AB - Synthetic organic chemicals can be used in personal care and consumer products. Data on potential human health effects of these chemicals are limited-sometimes even contradictory-but because several of these chemicals are toxic in experimental animals, alternative compounds are entering consumer markets. Nevertheless, limited information exists on consequent exposure trends to both the original chemicals and their replacements. Biomonitoring (measuring concentrations of chemicals or their metabolites in people) provides invaluable information for exposure assessment. We use phthalates and bisphenol A-known industrial chemicals-and organophosphate insecticides as case studies to show exposure trends to these chemicals and their replacements (e.g., other phthalates, non-phthalate plasticizers, various bisphenols, pyrethroid insecticides) among the US general population. We compare US trends to national trends from Canada and Germany. Exposure to the original compounds is still prevalent among these general populations, but exposures to alternative chemicals may be increasing. JF - Current environmental health reports AU - Calafat, Antonia M AU - Valentin-Blasini, Liza AU - Ye, Xiaoyun AD - Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F17, Atlanta, GA, 30341, USA. aic7@cdc.gov. ; Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F19, Atlanta, GA, 30341, USA. lbv5@cdc.gov. ; Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F53, Atlanta, GA, 30341, USA. xay5@cdc.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 348 EP - 355 VL - 2 IS - 4 KW - Benzhydryl Compounds KW - 0 KW - Cosmetics KW - Endocrine Disruptors KW - Insecticides KW - Organophosphates KW - Parabens KW - Phenols KW - Phthalic Acids KW - Plasticizers KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Phthalates KW - Exposure KW - Endocrine disruptors KW - Pesticides KW - Biomonitoring KW - DINCH KW - Bisphenol KW - United States KW - Animals KW - Consumer Product Safety -- standards KW - Canada KW - Humans KW - Surveys and Questionnaires KW - Parabens -- analysis KW - Endocrine Disruptors -- analysis KW - Germany KW - Insecticides -- analysis KW - Plasticizers -- analysis KW - Environmental Monitoring -- methods KW - Household Products -- analysis KW - Environmental Exposure -- analysis KW - Household Products -- adverse effects KW - Organophosphates -- analysis KW - Cosmetics -- adverse effects KW - Phthalic Acids -- analysis KW - Phenols -- analysis KW - Cosmetics -- chemistry KW - Benzhydryl Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728258448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+environmental+health+reports&rft.atitle=Trends+in+Exposure+to+Chemicals+in+Personal+Care+and+Consumer+Products.&rft.au=Calafat%2C+Antonia+M%3BValentin-Blasini%2C+Liza%3BYe%2C+Xiaoyun&rft.aulast=Calafat&rft.aufirst=Antonia&rft.date=2015-12-01&rft.volume=2&rft.issue=4&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Current+environmental+health+reports&rft.issn=2196-5412&rft_id=info:doi/10.1007%2Fs40572-015-0065-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-11 N1 - Date created - 2015-10-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40572-015-0065-9 ER - TY - JOUR T1 - Assessment of blood-brain barrier penetration of miltefosine used to treat a fatal case of granulomatous amebic encephalitis possibly caused by an unusual Balamuthia mandrillaris strain. AN - 1722185893; 26329128 AB - Balamuthia mandrillaris, a free-living ameba, causes rare but frequently fatal granulomatous amebic encephalitis (GAE). Few patients have survived after receiving experimental drug combinations, with or without brain lesion excisions. Some GAE survivors have been treated with a multi-drug regimen including miltefosine, an investigational anti-leishmanial agent with in vitro amebacidal activity. Miltefosine dosing for GAE has been based on leishmaniasis dosing because no data exist in humans concerning its pharmacologic distribution in the central nervous system. We describe results of limited cerebrospinal fluid (CSF) and serum drug level testing performed during clinical management of a child with fatal GAE who was treated with a multiple drug regimen including miltefosine. Brain biopsy specimens, CSF, and sera were tested for B. mandrillaris using multiple techniques, including culture, real-time polymerase chain reaction, immunohistochemical techniques, and serology. CSF and serum miltefosine levels were determined using a liquid chromatography method coupled to tandem mass spectrometry. The CSF miltefosine concentration on hospital admission day 12 was 0.4 μg/mL. The serum miltefosine concentration on day 37, about 80 h post-miltefosine treatment, was 15.3 μg/mL. These are the first results confirming some blood-brain barrier penetration by miltefosine in a human, although with low-level CSF accumulation. Further evaluation of brain parenchyma penetration is required to determine optimal miltefosine dosing for Balamuthia GAE, balanced with the drug's toxicity profile. Additionally, the Balamuthia isolate was evaluated by real-time polymerase chain reaction (PCR), demonstrating genetic variability in 18S ribosomal RNA (18S rRNA) sequences and possibly signaling the first identification of multiple Balamuthia strains with varying pathogenicities. JF - Parasitology research AU - Roy, Sharon L AU - Atkins, Jane T AU - Gennuso, Rosemaria AU - Kofos, Danny AU - Sriram, Rama R AU - Dorlo, Thomas P C AU - Hayes, Teresa AU - Qvarnstrom, Yvonne AU - Kucerova, Zuzana AU - Guglielmo, B Joseph AU - Visvesvara, Govinda S AD - Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA. str2@cdc.gov. ; Methodist Children's Hospital, San Antonio, TX, 78229, USA. ; Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA. ; Department of Pharmacy and Pharmacology, Slotervaart Hospital-The Netherlands Cancer Institute, 1066 EC, Amsterdam, The Netherlands. ; Department of Pathology, Methodist Hospital, San Antonio, TX, 78229, USA. ; Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA. ; Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, San Francisco, CA, 94143, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 4431 EP - 4439 VL - 114 IS - 12 KW - Amebicides KW - 0 KW - Phosphorylcholine KW - 107-73-3 KW - miltefosine KW - 53EY29W7EC KW - Index Medicus KW - Miltefosine KW - Granulomatous KW - Balamuthia KW - Encephalitis KW - Fatal Outcome KW - Humans KW - Brain -- pathology KW - Child KW - Brain -- parasitology KW - Male KW - Blood-Brain Barrier -- drug effects KW - Amebiasis -- parasitology KW - Phosphorylcholine -- administration & dosage KW - Balamuthia mandrillaris -- drug effects KW - Amebiasis -- drug therapy KW - Amebicides -- pharmacokinetics KW - Encephalitis -- drug therapy KW - Blood-Brain Barrier -- parasitology KW - Phosphorylcholine -- pharmacokinetics KW - Balamuthia mandrillaris -- isolation & purification KW - Amebicides -- administration & dosage KW - Encephalitis -- parasitology KW - Phosphorylcholine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722185893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Parasitology+research&rft.atitle=Assessment+of+blood-brain+barrier+penetration+of+miltefosine+used+to+treat+a+fatal+case+of+granulomatous+amebic+encephalitis+possibly+caused+by+an+unusual+Balamuthia+mandrillaris+strain.&rft.au=Roy%2C+Sharon+L%3BAtkins%2C+Jane+T%3BGennuso%2C+Rosemaria%3BKofos%2C+Danny%3BSriram%2C+Rama+R%3BDorlo%2C+Thomas+P+C%3BHayes%2C+Teresa%3BQvarnstrom%2C+Yvonne%3BKucerova%2C+Zuzana%3BGuglielmo%2C+B+Joseph%3BVisvesvara%2C+Govinda+S&rft.aulast=Roy&rft.aufirst=Sharon&rft.date=2015-12-01&rft.volume=114&rft.issue=12&rft.spage=4431&rft.isbn=&rft.btitle=&rft.title=Parasitology+research&rft.issn=1432-1955&rft_id=info:doi/10.1007%2Fs00436-015-4684-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-24 N1 - Date created - 2015-10-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Microbiol. 2003 Jul;41(7):3175-80 [12843060] Clin Infect Dis. 2003 Nov 15;37(10):1304-12 [14583863] Arch Pathol Lab Med. 2004 Apr;128(4):466-8 [15043486] Microbiology. 2004 Sep;150(Pt 9):2837-42 [15347743] Vet Pathol. 2004 Sep;41(5):506-10 [15347823] Emerg Infect Dis. 2004 Aug;10(8):1510-2 [15503402] Cancer Treat Rev. 1990 Sep;17(2-3):233-42 [2272038] J Clin Microbiol. 1990 Dec;28(12):2750-6 [2280005] Cancer Chemother Pharmacol. 1992;31(1):18-22 [1458555] J Eukaryot Microbiol. 1993 Jul-Aug;40(4):504-14 [8330028] J Clin Microbiol. 1996 Feb;34(2):385-8 [8789020] Antimicrob Agents Chemother. 1996 Mar;40(3):825-6 [8851625] Med J Aust. 1997 Jul 21;167(2):82-4 [9251693] J Infect Dis. 1999 May;179(5):1305-8 [10191243] J Eukaryot Microbiol. 2006 Mar-Apr;53(2):121-6 [16579814] Clin Infect Dis. 2006 May 1;42(9):1260-5 [16586385] J Clin Microbiol. 2006 Oct;44(10):3589-95 [17021087] Parasitol Res. 2007 Jan;100(2):423-6 [17033842] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Apr 1;865(1-2):55-62 [18325856] Antimicrob Agents Chemother. 2008 Aug;52(8):2855-60 [18519729] Parasitol Res. 2009 Feb;104(3):663-70 [19039606] Clin Infect Dis. 2009 Apr 1;48(7):879-87 [19236272] J Immunol. 2009 Jun 1;182(11):7146-54 [19454711] Parasitol Res. 2009 Dec;106(1):279-81 [19685076] Pediatrics. 2010 Mar;125(3):e699-703 [20123772] Clin Infect Dis. 2010 Jul 15;51(2):e7-11 [20550438] MMWR Morb Mortal Wkly Rep. 2010 Sep 17;59(36):1165-70 [20847719] Clin Microbiol Rev. 2010 Oct;23(4):858-83 [20930076] Curr Opin Infect Dis. 2011 Apr;24(2):112-7 [21192259] J Eukaryot Microbiol. 2011 May-Jun;58(3):269-71 [21435080] Clin Vaccine Immunol. 2011 Aug;18(8):1297-301 [21653740] Antimicrob Agents Chemother. 2012 Jul;56(7):3864-72 [22585212] J Antimicrob Chemother. 2012 Nov;67(11):2576-97 [22833634] MMWR Morb Mortal Wkly Rep. 2013 Aug 23;62(33):666 [23965830] J Eukaryot Microbiol. 2013 Nov-Dec;60(6):626-33 [23879685] J Clin Microbiol. 2003 Jan;41(1):453-5 [12517892] Am J Trop Med Hyg. 2003 Jan;68(1):65-9 [12556151] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00436-015-4684-8 ER - TY - JOUR T1 - What Is the Added Benefit of Oropharyngeal Swabs Compared to Nasal Swabs Alone for Respiratory Virus Detection in Hospitalized Children Aged <10 Years? AN - 1776653913; PQ0002734363 AB - We evaluated the added value of collecting both nasal and oropharyngeal swabs, compared with collection of nasal swabs alone, for detection of common respiratory viruses by reverse transcription-polymerase chain reaction in hospitalized children aged <10 years. Nasal swabs had equal or greater sensitivity than oropharyngeal swabs for detection of respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus, and influenza virus but not parainfluenza virus. The addition of an oropharyngeal swab, compared with use of a nasal swab alone, increased the frequency of detection of each respiratory virus by no more than 10% in children aged <10 years. JF - Journal of Infectious Diseases AU - Dawood, Fatimah S AU - Jara, Jorge AU - Estripeaut, Dora AU - Vergara, Ofelina AU - Luciani, Kathia AU - Corro, Mary AU - de Leon, Tirza AU - Saldana, Ricardo AU - Baires, Juan Miguel Castillo AU - Flores, Rafael Rauda AD - Influenza Division, fdawood@cdc.gov Y1 - 2015/11/15/ PY - 2015 DA - 2015 Nov 15 SP - 1600 EP - 1603 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 10 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - influenza, human KW - respiratory syncytial virus infections KW - parainfluenza KW - human metapneumovirus KW - children, hospitalized KW - Sensitivity KW - Viruses KW - Adenovirus KW - Children KW - Parainfluenza virus KW - Parainfluenza KW - Respiratory syncytial virus KW - Influenza KW - Influenza virus KW - Infectious diseases KW - Human metapneumovirus KW - Rhinovirus KW - Hospitals KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776653913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=What+Is+the+Added+Benefit+of+Oropharyngeal+Swabs+Compared+to+Nasal+Swabs+Alone+for+Respiratory+Virus+Detection+in+Hospitalized+Children+Aged+%26lt%3B10+Years%3F&rft.au=Dawood%2C+Fatimah+S%3BJara%2C+Jorge%3BEstripeaut%2C+Dora%3BVergara%2C+Ofelina%3BLuciani%2C+Kathia%3BCorro%2C+Mary%3Bde+Leon%2C+Tirza%3BSaldana%2C+Ricardo%3BBaires%2C+Juan+Miguel+Castillo%3BFlores%2C+Rafael+Rauda&rft.aulast=Dawood&rft.aufirst=Fatimah&rft.date=2015-11-15&rft.volume=212&rft.issue=10&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv265 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Influenza; Children; Parainfluenza; Sensitivity; Infectious diseases; Viruses; Hospitals; Respiratory syncytial virus; Influenza virus; Human metapneumovirus; Adenovirus; Rhinovirus; Parainfluenza virus DO - http://dx.doi.org/10.1093/infdis/jiv265 ER - TY - JOUR T1 - Mortality Risk After AIDS-Defining Opportunistic Illness Among HIV-Infected Persons-San Francisco, 1981-2012 AN - 1776654352; PQ0002734349 AB - Objective. To examine whether improved human immunodeficiency virus (HIV) treatment was associated with better survival after diagnosis of AIDS-defining opportunistic illnesses (AIDS-OIs) and how survival differed by AIDS-OI. Design. We used HIV surveillance data to conduct a survival analysis. Methods. We estimated survival probabilities after first AIDS-OI diagnosis among adult patients with AIDS in San Francisco during 3 treatment eras: 1981-1986; 1987-1996; and 1997-2012. We used Cox proportional hazards models to determine adjusted mortality risk by AIDS-OI in the years 1997-2012. Results. Among 20 858 patients with AIDS, the most frequently diagnosed AIDS-OIs were Pneumocystis pneumonia (39.1%) and Kaposi sarcoma (20.1%). Overall 5-year survival probability increased from 7% in 1981-1986 to 65% in 1997-2012. In 1997-2012, after adjustment for known confounders and using Pneumocystis pneumonia as the referent category, mortality rates after first AIDS-OI were highest for brain lymphoma (hazard ratio [HR], 5.14; 95% confidence interval [CI], 2.98-8.87) and progressive multifocal leukoencephalopathy (HR, 4.22; 95% CI, 2.49-7.17). Conclusions. Survival after first AIDS-OI diagnosis has improved markedly since 1981. Some AIDS-OIs remain associated with substantially higher mortality risk than others, even after adjustment for known confounders. Better prevention and treatment strategies are still needed for AIDS-OIs occurring in the current HIV treatment era. JF - Journal of Infectious Diseases AU - Djawe, Kpandja AU - Buchacz, Kate AU - Hsu, Ling AU - Chen, Miao-Jung AU - Selik, Richard M AU - Rose, Charles AU - Williams, Tiffany AU - Brooks, John T AU - Schwarcz, Sandra AD - Division of HIV/AIDS Prevention, kdjawe@cdc.gov Y1 - 2015/11/01/ PY - 2015 DA - 2015 Nov 01 SP - 1366 EP - 1375 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 9 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - AIDS KW - AIDS-defining illness KW - mortality KW - HIV KW - survival KW - Mortality KW - Acquired immune deficiency syndrome KW - Data processing KW - Pneumocystis KW - Brain KW - Survival KW - Progressive multifocal leukoencephalopathy KW - Models KW - Prevention KW - Infectious diseases KW - Human immunodeficiency virus KW - Risk factors KW - Sarcoma KW - INE, USA, California, San Francisco KW - Lymphoma KW - Pneumonia KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776654352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Mortality+Risk+After+AIDS-Defining+Opportunistic+Illness+Among+HIV-Infected+Persons-San+Francisco%2C+1981-2012&rft.au=Djawe%2C+Kpandja%3BBuchacz%2C+Kate%3BHsu%2C+Ling%3BChen%2C+Miao-Jung%3BSelik%2C+Richard+M%3BRose%2C+Charles%3BWilliams%2C+Tiffany%3BBrooks%2C+John+T%3BSchwarcz%2C+Sandra&rft.aulast=Djawe&rft.aufirst=Kpandja&rft.date=2015-11-01&rft.volume=212&rft.issue=9&rft.spage=1366&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv235 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Mortality; Acquired immune deficiency syndrome; Data processing; Risk factors; Sarcoma; Brain; Survival; Progressive multifocal leukoencephalopathy; Lymphoma; Pneumonia; Models; Prevention; Infectious diseases; Human immunodeficiency virus; Pneumocystis; INE, USA, California, San Francisco DO - http://dx.doi.org/10.1093/infdis/jiv235 ER - TY - JOUR T1 - Staphylococcus aureus Colonization and Strain Type at Various Body Sites among Patients with a Closed Abscess and Uninfected Controls at U.S. Emergency Departments AN - 1751215332; PQ0002308805 AB - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a prevalent cause of skin and soft tissue infections (SSTI), but the association between CA-MRSA colonization and infection remains uncertain. We studied the carriage frequency at several body sites and the diversity of S. aureus strains from patients with and without SSTI. Specimens from the nares, throat, rectum, and groin of case subjects with a closed skin abscess (i.e., without drainage) and matched control subjects without a skin infection (n = 147 each) presenting to 10 U.S. emergency departments were cultured using broth enrichment; wound specimens were cultured from abscess cases. Methicillin resistance testing and spa typing were performed for all S. aureus isolates. S. aureus was found in 85/147 (57.8%) of abscesses; 49 isolates were MRSA, and 36 were methicillin-susceptible S. aureus (MSSA). MRSA colonization was more common among cases (59/147; 40.1%) than among controls (27/147; 18.4%) overall (P < 0.001) and at each body site; no differences were observed for MSSA. S. aureus-infected subjects were usually (75/85) colonized with the infecting strain; among MRSA-infected subjects, this was most common in the groin. The CC8 lineage accounted for most of both infecting and colonizing isolates, although more than 16 distinct strains were identified. Nearly all MRSA infections were inferred to be USA300. There was more diversity among colonizing than infecting isolates and among those isolated from controls versus cases. CC8 S. aureus is a common colonizer of persons with and without skin infections. Detection of S. aureus colonization, and especially MRSA, may be enhanced by extranasal site culture. JF - Journal of Clinical Microbiology AU - Albrecht, Valerie S AU - Limbago, Brandi M AU - Moran, Gregory J AU - Krishnadasan, Anusha AU - Gorwitz, Rachel J AU - McDougal, Linda K AU - Talan, David A AD - << + $0, BBL7@cdc.gov. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 3478 EP - 3484 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 11 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Skin KW - Rectum KW - Pharynx KW - Drug resistance KW - Drainage KW - Infection KW - Abscesses KW - Wounds KW - Colonization KW - Typing KW - Methicillin KW - Staphylococcus aureus KW - Soft tissues KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751215332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Staphylococcus+aureus+Colonization+and+Strain+Type+at+Various+Body+Sites+among+Patients+with+a+Closed+Abscess+and+Uninfected+Controls+at+U.S.+Emergency+Departments&rft.au=Albrecht%2C+Valerie+S%3BLimbago%2C+Brandi+M%3BMoran%2C+Gregory+J%3BKrishnadasan%2C+Anusha%3BGorwitz%2C+Rachel+J%3BMcDougal%2C+Linda+K%3BTalan%2C+David+A&rft.aulast=Albrecht&rft.aufirst=Valerie&rft.date=2015-11-01&rft.volume=53&rft.issue=11&rft.spage=3478&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01371-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 31 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Colonization; Pharynx; Methicillin; Rectum; Typing; Skin; Drainage; Drug resistance; Abscesses; Infection; Soft tissues; Wounds; Staphylococcus aureus DO - http://dx.doi.org/10.1128/JCM.01371-15 ER - TY - GEN T1 - Editorial utility of population-based birth defects surveillance for monitoring the health of infants and as a foundation for etiologic research. AN - 1737477655; 26458078 JF - Birth defects research. Part A, Clinical and molecular teratology AU - Moore, Cynthia A AU - McCabe, Edward R B Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 895 EP - 898 VL - 103 IS - 11 KW - Index Medicus KW - Infant KW - Humans KW - United States -- epidemiology KW - Biomedical Research KW - Health Status KW - Congenital Abnormalities -- epidemiology KW - Congenital Abnormalities -- etiology KW - Population Surveillance -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737477655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Editorial+utility+of+population-based+birth+defects+surveillance+for+monitoring+the+health+of+infants+and+as+a+foundation+for+etiologic+research.&rft.au=Moore%2C+Cynthia+A%3BMcCabe%2C+Edward+R+B&rft.aulast=Moore&rft.aufirst=Cynthia&rft.date=2015-11-01&rft.volume=103&rft.issue=11&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23421 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-13 N1 - Date created - 2015-11-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Public Health. 2005 Nov;95(11):1884-6 [16195507] Birth Defects Res A Clin Mol Teratol. 2007 Feb;79(2):65-186 [17278144] PLoS One. 2013;8(7):e69077 [23874873] Pediatrics. 2013 Jan;131(1):e27-36 [23248222] MMWR Suppl. 2012 Jul 27;61(3):20-4 [22832993] MMWR Suppl. 2012 Jul 27;61(3):3-9 [22832990] Neurology. 2012 Jun 5;78(23):1886-91 [22665145] J Pediatr. 2012 Jun;160(6):978-83 [22244463] Arch Pediatr Adolesc Med. 2012 Feb;166(2):121-6 [21969361] Am J Prev Med. 2011 May;40(5 Suppl 2):S154-8 [21521589] Am J Obstet Gynecol. 2011 Apr;204(4):314.e1-11 [21345403] Birth Defects Res A Clin Mol Teratol. 2009 Nov;85(11):925-34 [19830851] Birth Defects Res A Clin Mol Teratol. 2015 Aug;103(8):656-69 [26033852] Birth Defects Res A Clin Mol Teratol. 2015 Aug;103(8):733-40 [25846741] J Epidemiol Community Health. 2015 Jul;69(7):693-9 [25805603] J Pediatr. 2015 Apr;166(4):819-26.e1-2 [25641238] Birth Defects Res A Clin Mol Teratol. 2015 Feb;103(2):127-43 [25721952] Am J Emerg Med. 2014 Nov;32(11):1417 [25200509] Birth Defects Res A Clin Mol Teratol. 2014 Nov;100(11):837-47 [25200965] Milbank Q. 2014 Mar;92(1):7-33 [24597553] Birth Defects Res A Clin Mol Teratol. 2013 Oct;97(10):685-95 [24039055] J Med Internet Res. 2013;15(7):e147 [23896182] Arch Pediatr Adolesc Med. 2007 Aug;161(8):745-50 [17679655] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23421 ER - TY - CPAPER T1 - Clinical presentation of pregnant women at isolation centers for Ebola Virus Disease in Sierra Leone, 2014 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771059; 6365487 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Johnson, Jonetta AU - Callaghan, William AU - Elamin, Hayfa AU - Ellington, Sascha AU - Kargbo, Samuel AU - Koroma, Alimamy AU - Lyman, Meghan AU - Morof, Diane AU - Soud, Fatma Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Viruses KW - Sierra Leone KW - Pregnancy KW - Ebola virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Use+of+expedited+partner+therapy+among+chlamydia+cases+diagnosed+at+an+urban+Indian+health+centre%2C+Arizona&rft.au=Taylor%2C+M+M%3BReilley%2C+B%3BYellowman%2C+M%3BAnderson%2C+L%3Bde+Ravello%2C+L%3BTulloch%2C+S&rft.aulast=Taylor&rft.aufirst=M&rft.date=2013-05-01&rft.volume=24&rft.issue=5&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462412472825 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Strategic Risk Communication in a Black Swan Event T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731770918; 6365386 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Telfer, Jana AU - Said, Jonathan AU - Olivares, Dagny Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Communication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731770918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Strategic+Risk+Communication+in+a+Black+Swan+Event&rft.au=Telfer%2C+Jana%3BSaid%2C+Jonathan%3BOlivares%2C+Dagny&rft.aulast=Telfer&rft.aufirst=Jana&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Order amid Chaos: Structuring communication functions to amplify effectiveness in Ebola Time T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731770731; 6365383 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Telfer, Jana AU - Olivares, Dagny Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Viruses KW - Communication KW - Chaos theory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731770731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Order+amid+Chaos%3A+Structuring+communication+functions+to+amplify+effectiveness+in+Ebola+Time&rft.au=Telfer%2C+Jana%3BOlivares%2C+Dagny&rft.aulast=Telfer&rft.aufirst=Jana&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Assessment of ICD-9-CM Codes included in the CDC's Definition of a Traumatic Brain Injury T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768221; 6366568 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Haarbauer-Krupa, Juliet AU - Hirsch, Shawn AU - Coronado, Victor AU - Valdes, Raydel AU - Lowe, Brooks AU - Register-Mihalik, Johna Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Brain KW - Traumatic brain injury UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Assessment+of+ICD-9-CM+Codes+included+in+the+CDC%27s+Definition+of+a+Traumatic+Brain+Injury&rft.au=Haarbauer-Krupa%2C+Juliet%3BHirsch%2C+Shawn%3BCoronado%2C+Victor%3BValdes%2C+Raydel%3BLowe%2C+Brooks%3BRegister-Mihalik%2C+Johna&rft.aulast=Haarbauer-Krupa&rft.aufirst=Juliet&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Ebola Must GO: Stopping Ebola is Everybody's Business T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764861; 6367738 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Telfer, Jana AU - Harrington, Peter AU - Douglas, Stephen AU - Huebner, Nathan AU - Warren, Felicia Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Viruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Ebola+Must+GO%3A+Stopping+Ebola+is+Everybody%27s+Business&rft.au=Telfer%2C+Jana%3BHarrington%2C+Peter%3BDouglas%2C+Stephen%3BHuebner%2C+Nathan%3BWarren%2C+Felicia&rft.aulast=Telfer&rft.aufirst=Jana&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Sandbox Play: CDC's Prevention Research Centers' partnerships with health agencies in the context of core research project types and CDC's National Center for Chronic Disease Prevention and Health Promotion's priority domains T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764686; 6367729 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Croston, Merriah Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Prevention KW - Priorities KW - Governments KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Persistence+of+deposited+metals+in+the+lungs+after+stainless+steel+and+mild+steel+welding+fume+inhalation+in+rats.&rft.au=Antonini%2C+James+M%3BRoberts%2C+Jenny+R%3BStone%2C+Samuel%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BChapman%2C+Rebecca%3BZeidler-Erdely%2C+Patti+C%3BAndrews%2C+Ronnee+N%3BFrazer%2C+David+G&rft.aulast=Antonini&rft.aufirst=James&rft.date=2011-05-01&rft.volume=85&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-010-0601-1 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Oral Health Status of Adults aged >= 40 years with Vision Impairment or Eye Diseases: Findings from the National Health Interview Survey, 2008 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731763772; 6366003 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Crews, John AU - Chou, Chiu-Fang AU - Saaddine, Jinan AU - Naavaal, Shillpa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Vision KW - Eye diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Oral+Health+Status+of+Adults+aged+%26gt%3B%3D+40+years+with+Vision+Impairment+or+Eye+Diseases%3A+Findings+from+the+National+Health+Interview+Survey%2C+2008&rft.au=Crews%2C+John%3BChou%2C+Chiu-Fang%3BSaaddine%2C+Jinan%3BNaavaal%2C+Shillpa&rft.aulast=Crews&rft.aufirst=John&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Are the Associations between Adverse Childhood Experiences and Chronic Diseases Stronger in Women than in Men? T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760381; 6367175 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Cunningham, Timothy AU - Ford, Earl AU - Wheaton, Anne AU - Merrick, Melissa AU - Croft, Janet AU - Giles, Wayne Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Children UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Are+the+Associations+between+Adverse+Childhood+Experiences+and+Chronic+Diseases+Stronger+in+Women+than+in+Men%3F&rft.au=Cunningham%2C+Timothy%3BFord%2C+Earl%3BWheaton%2C+Anne%3BMerrick%2C+Melissa%3BCroft%2C+Janet%3BGiles%2C+Wayne&rft.aulast=Cunningham&rft.aufirst=Timothy&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Causes of Death among Patients with Bleeding Disorders Receiving Care at US Hemophilia Treatment Centers, October 2011-December 2014 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760371; 6366758 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Oakley, Meredith Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mortality KW - Bleeding KW - Hemophilia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Causes+of+Death+among+Patients+with+Bleeding+Disorders+Receiving+Care+at+US+Hemophilia+Treatment+Centers%2C+October+2011-December+2014&rft.au=Oakley%2C+Meredith&rft.aulast=Oakley&rft.aufirst=Meredith&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Knowledge, Attitudes, and Beliefs Related to Hypertension and High Cholesterol Self-Management among African American Men living in the Southeastern United States T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760302; 6366913 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Long, Everett AU - Ponder, Monica AU - Bernard, Stephanie AU - Lane, Rashon Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Attitudes KW - Cholesterol KW - USA, Southeast KW - Ethnic groups KW - Hypertension UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Knowledge%2C+Attitudes%2C+and+Beliefs+Related+to+Hypertension+and+High+Cholesterol+Self-Management+among+African+American+Men+living+in+the+Southeastern+United+States&rft.au=Long%2C+Everett%3BPonder%2C+Monica%3BBernard%2C+Stephanie%3BLane%2C+Rashon&rft.aulast=Long&rft.aufirst=Everett&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Integrating Pharmacies into Pandemic Influenza Vaccine Response Planning T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760021; 6364727 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Fitzgerald, Thomas AU - Graitcer, Samuel AU - Kang, Yoonjae Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Influenza KW - pandemics KW - Disease control KW - Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Clam-associated+vibriosis%2C+USA%2C+1988-2010&rft.au=Slayton%2C+R+B%3BNewton%2C+A+E%3BDepaola%2C+A%3BJones%2C+J+L%3BMahon%2C+B+E&rft.aulast=Slayton&rft.aufirst=R&rft.date=2014-05-01&rft.volume=142&rft.issue=5&rft.spage=1083&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268813001830 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - Emergence of Multidrug-Resistant Influenza A(H1N1)pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir AN - 1773859747; PQ0002721034 AB - Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by 4 NA inhibitors: oseltamivir, zanamivir, peramivir, and laninamivir. JF - Journal of Infectious Diseases AU - Tamura, Daisuke AU - Debiasi, Roberta L AU - Okomo-Adhiambo, Margaret AU - Mishin, Vasiliy P AU - Campbell, Angela P AU - Loechelt, Brett AU - Wiedermann, Bernhard L AU - Fry, Alicia M AU - Gubareva, Larisa V AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, lgubareva@cdc.gov Y1 - 2015/10/15/ PY - 2015 DA - 2015 Oct 15 SP - 1209 EP - 1213 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 8 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - neuraminidase KW - drug resistance KW - pyrosequencing KW - oseltamivir KW - zanamivir KW - Influenza KW - Infectious diseases KW - Drug resistance KW - Viruses KW - Exo- alpha -sialidase KW - Infection KW - Zanamivir KW - Oseltamivir KW - H 0500:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773859747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Emergence+of+Multidrug-Resistant+Influenza+A%28H1N1%29pdm09+Virus+Variants+in+an+Immunocompromised+Child+Treated+With+Oseltamivir+and+Zanamivir&rft.au=Tamura%2C+Daisuke%3BDebiasi%2C+Roberta+L%3BOkomo-Adhiambo%2C+Margaret%3BMishin%2C+Vasiliy+P%3BCampbell%2C+Angela+P%3BLoechelt%2C+Brett%3BWiedermann%2C+Bernhard+L%3BFry%2C+Alicia+M%3BGubareva%2C+Larisa+V&rft.aulast=Tamura&rft.aufirst=Daisuke&rft.date=2015-10-15&rft.volume=212&rft.issue=8&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Influenza; Drug resistance; Exo- alpha -sialidase; Infection; Zanamivir; Oseltamivir; Infectious diseases; Viruses DO - http://dx.doi.org/10.1093/infdis/jiv245 ER - TY - JOUR T1 - Relationship Between Ebola Virus Real-Time Quantitative Polymerase Chain Reaction-Based Threshold Cycle Value and Virus Isolation From Human Plasma AN - 1780502787; PQ0002879716 AB - We performed a longitudinal analysis of plasma samples obtained from 4 patients with Ebola virus (EBOV) disease (EVD) to determine the relationship between the real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR)-based threshold cycle (Ct) value and the presence of infectious EBOV. EBOV was not isolated from plasma samples with a Ct value of >35.5 or >12 days after onset of symptoms. EBOV was not isolated from plasma samples in which anti-EBOV nucleoprotein immunoglobulin G was detected. These data demonstrate the utility of interpreting qRT-PCR results in the context of the course of EBOV infection and associated serological responses for patient-management decisions. JF - Journal of Infectious Diseases AU - Spengler, Jessica R AU - McElroy, Anita K AU - Harmon, Jessica R AU - Stroher, Ute AU - Nichol, Stuart T AU - Spiropoulou, Christina F AD - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, ccs8@cdc.gov Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - S346 EP - S349 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Ebola KW - qRT-PCR KW - virus isolation KW - Data processing KW - Infectious diseases KW - Viruses KW - Nucleoproteins KW - Immunoglobulin G KW - RNA-directed DNA polymerase KW - Polymerase chain reaction KW - Ebola virus KW - Infection KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780502787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Relationship+Between+Ebola+Virus+Real-Time+Quantitative+Polymerase+Chain+Reaction-Based+Threshold+Cycle+Value+and+Virus+Isolation+From+Human+Plasma&rft.au=Spengler%2C+Jessica+R%3BMcElroy%2C+Anita+K%3BHarmon%2C+Jessica+R%3BStroher%2C+Ute%3BNichol%2C+Stuart+T%3BSpiropoulou%2C+Christina+F&rft.aulast=Spengler&rft.aufirst=Jessica&rft.date=2015-10-01&rft.volume=212&rft.issue=&rft.spage=S346&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv187 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Data processing; Nucleoproteins; Immunoglobulin G; Polymerase chain reaction; RNA-directed DNA polymerase; Infection; Infectious diseases; Viruses; Ebola virus DO - http://dx.doi.org/10.1093/infdis/jiv187 ER - TY - JOUR T1 - Multidistrict Outbreak of Marburg Virus DiseaseemdashUganda, 2012 AN - 1780498458; PQ0002879689 AB - In October 2012, a cluster of illnesses and deaths was reported in Uganda and was confirmed to be an outbreak of Marburg virus disease (MVD). Patients meeting the case criteria were interviewed using a standard investigation form, and blood specimens were tested for evidence of acute or recent Marburg virus infection by reverse transcription-polymerase chain reaction (RT-PCR) and antibody enzyme-linked immunosorbent assay. The total count of confirmed and probable MVD cases was 26, of which 15 (58%) were fatal. Four of 15 laboratory-confirmed cases (27%) were fatal. Case patients were located in 4 different districts in Uganda, although all chains of transmission originated in Ibanda District, and the earliest case detected had an onset in July 2012. No zoonotic exposures were identified. Symptoms significantly associated with being a MVD case included hiccups, anorexia, fatigue, vomiting, sore throat, and difficulty swallowing. Contact with a case patient and attending a funeral were also significantly associated with being a case. Average RT-PCR cycle threshold values for fatal cases during the acute phase of illness were significantly lower than those for nonfatal cases. Following the institution of contact tracing, active case surveillance, care of patients with isolation precautions, community mobilization, and rapid diagnostic testing, the outbreak was successfully contained 14 days after its initial detection. JF - Journal of Infectious Diseases AU - Knust, Barbara AU - Schafer, Ilana J AU - Wamala, Joseph AU - Nyakarahuka, Luke AU - Okot, Charles AU - Shoemaker, Trevor AU - Dodd, Kimberly AU - Gibbons, Aridth AU - Balinandi, Stephen AU - Tumusiime, Alex AD - Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, bknust@cdc.gov Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - S119 EP - S128 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Marburg virus KW - filoviruses KW - hemorrhagic fever KW - zoonotic disease KW - outbreak response KW - Mortality KW - swallowing KW - Enzyme-linked immunosorbent assay KW - Fatigue KW - Vomiting KW - Uganda KW - Pharyngitis KW - Infection KW - Contact tracing KW - Disease transmission KW - Blood KW - Antibodies KW - Infectious diseases KW - anorexia KW - Polymerase chain reaction KW - Outbreaks KW - Immunoassays KW - H 0500:General KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780498458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Multidistrict+Outbreak+of+Marburg+Virus+DiseaseemdashUganda%2C+2012&rft.au=Knust%2C+Barbara%3BSchafer%2C+Ilana+J%3BWamala%2C+Joseph%3BNyakarahuka%2C+Luke%3BOkot%2C+Charles%3BShoemaker%2C+Trevor%3BDodd%2C+Kimberly%3BGibbons%2C+Aridth%3BBalinandi%2C+Stephen%3BTumusiime%2C+Alex&rft.aulast=Knust&rft.aufirst=Barbara&rft.date=2015-10-01&rft.volume=212&rft.issue=&rft.spage=S119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - swallowing; Blood; Antibodies; Enzyme-linked immunosorbent assay; Vomiting; Fatigue; anorexia; Polymerase chain reaction; Pharyngitis; Contact tracing; Infection; Disease transmission; Mortality; Infectious diseases; Outbreaks; Immunoassays; Marburg virus; Uganda DO - http://dx.doi.org/10.1093/infdis/jiv351 ER - TY - JOUR T1 - Human Monkeypox in the Kivus, a Conflict Region of the Democratic Republic of the Congo AN - 1765987643; PQ0002617708 AB - Monkeypox (MPX) is a zoonotic Orthopoxvirus infection endemic in central and western Africa. Human MPX cases occur in the central and northern regions of the Democratic Republic of the Congo (DRC), and this is the first report of confirmed MPX cases in the forested areas of North and South Kivu Provinces, with a detailed epidemiological investigation for one case. The location of each case is within areas predicted to be suitable for MPX virus transmission based on an ecological niche model. Phylogenetic analysis places these viruses in the Congo Basin clade. JF - American Journal of Tropical Medicine and Hygiene AU - McCollum, Andrea M AU - Nakazawa, Yoshinori AU - Ndongala, Guy Mutombo AU - Pukuta, Elisabeth AU - Karhemere, Stomy AU - Lushima, Robert Shongo AU - Ilunga, Benoit Kebela AU - Kabamba, Joelle AU - Wilkins, Kimberly AU - Gao, Jinxin AD - Poxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, azv4@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 718 EP - 721 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Phylogeny KW - New records KW - Orthopoxvirus KW - Monkeypox KW - Ecological distribution KW - Niches KW - Viruses KW - Basins KW - Infection KW - Models KW - Disease transmission KW - Endemic species KW - Africa KW - Conflicts KW - Hygiene KW - Phylogenetics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765987643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Human+Monkeypox+in+the+Kivus%2C+a+Conflict+Region+of+the+Democratic+Republic+of+the+Congo&rft.au=McCollum%2C+Andrea+M%3BNakazawa%2C+Yoshinori%3BNdongala%2C+Guy+Mutombo%3BPukuta%2C+Elisabeth%3BKarhemere%2C+Stomy%3BLushima%2C+Robert+Shongo%3BIlunga%2C+Benoit+Kebela%3BKabamba%2C+Joelle%3BWilkins%2C+Kimberly%3BGao%2C+Jinxin&rft.aulast=McCollum&rft.aufirst=Andrea&rft.date=2015-10-01&rft.volume=93&rft.issue=4&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0095 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - New records; Endemic species; Niches; Ecological distribution; Viruses; Hygiene; Phylogenetics; Disease transmission; Phylogeny; Monkeypox; Basins; Infection; Models; Conflicts; Orthopoxvirus; Africa DO - http://dx.doi.org/10.4269/ajtmh.15-0095 ER - TY - JOUR T1 - Border Lookout: Enhancing Tuberculosis Control on the United States-Mexico Border AN - 1765987445; PQ0002617713 AB - We evaluated the use of federal public health intervention tools known as the Do Not Board and Border Lookout (BL) for detecting and referring infectious or potentially infectious land border travelers with tuberculosis (TB) back to treatment. We used data about the issuance of BL from April 2007 to September 2013 to examine demographics and TB laboratory results for persons on the list (N = 66) and time on the list before being located and achieving noninfectious status. The majority of case-patients were Hispanic and male, with a median age of 39 years. Most were citizens of the United States or Mexico, and 30.3% were undocumented migrants. One-fifth had multidrug-resistant TB. Nearly two-thirds of case-patients were located and treated as a result of being placed on the list. However, 25.8% of case-patients, primarily undocumented migrants, remain lost to follow-up and remain on the list. For this highly mobile patient population, the use of this novel federal travel intervention tool facilitated the detection and treatment of infectious TB cases that were lost to follow-up. JF - American Journal of Tropical Medicine and Hygiene AU - DeSisto, Carla AU - Broussard, Kelly AU - Escobedo, Miguel AU - Borntrager, Denise AU - Alvarado-Ramy, Francisco AU - Waterman, Stephen AD - Division of Global Migration and Quarantine, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, carla.desisto@gmail.com Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 747 EP - 751 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Health & Safety Science Abstracts KW - Travel KW - Age KW - Data processing KW - Mycobacterium KW - Drug resistance KW - Disease control KW - Intervention KW - Public health KW - Demography KW - USA KW - Mexico KW - Tuberculosis KW - Hygiene KW - International boundaries KW - Migrants KW - Ethnic groups KW - K 03400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - J 02400:Human Diseases KW - H 12000:Epidemiology and Public Health KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765987445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Border+Lookout%3A+Enhancing+Tuberculosis+Control+on+the+United+States-Mexico+Border&rft.au=DeSisto%2C+Carla%3BBroussard%2C+Kelly%3BEscobedo%2C+Miguel%3BBorntrager%2C+Denise%3BAlvarado-Ramy%2C+Francisco%3BWaterman%2C+Stephen&rft.aulast=DeSisto&rft.aufirst=Carla&rft.date=2015-10-01&rft.volume=93&rft.issue=4&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0300 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Disease control; Tuberculosis; Hygiene; Public health; Travel; Demography; Age; Data processing; Drug resistance; Intervention; International boundaries; Ethnic groups; Migrants; Mycobacterium; USA; Mexico DO - http://dx.doi.org/10.4269/ajtmh.15-0300 ER - TY - JOUR T1 - A farewell to didanosine: harm reduction and cost savings by eliminating use of didanosine AN - 1765981547; PQ0002583996 AB - Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor associated with adverse events and public health concerns which have diminished its place in HIV clinical practice, particularly in resource-rich settings. While international guidelines do not contain ddI-containing regimens in preferred first- or second-line antiretroviral therapy (ART), there is no guidance for management of patients currently on ddI. In 2012 at least 20 countries purchased a total of $1-2 million of ddI. Drug purchase data in that year show 3.2-10.3 times higher costs for ddI compared to lamivudine (3TC). Given issues of multiple toxicities, monitoring, drug interactions, inconvenience, and virologic efficacy, as well as cost and formulary concerns, national (including resource-limited setting) ART programmes should consider complete phase-out of ddI. JF - International Journal of STD & AIDS AU - Dziuban, Eric J AU - Raizes, Elliot AU - Koumans, Emilia H Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 903 EP - 906 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 26 IS - 12 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Didanosine KW - HIV KW - AIDS KW - treatment KW - antiretroviral therapy KW - reverse transcriptase inhibitors KW - drug toxicity KW - drug interactions KW - Drug interaction KW - Acquired immune deficiency syndrome KW - Data processing KW - Guidelines KW - Lamivudine KW - Risk reduction KW - Toxicity KW - Antiretroviral agents KW - Public health KW - Human immunodeficiency virus KW - Drugs KW - Side effects KW - Sexually transmitted diseases KW - nucleoside reverse transcriptase inhibitors KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765981547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=A+farewell+to+didanosine%3A+harm+reduction+and+cost+savings+by+eliminating+use+of+didanosine&rft.au=Dziuban%2C+Eric+J%3BRaizes%2C+Elliot%3BKoumans%2C+Emilia+H&rft.aulast=Dziuban&rft.aufirst=Eric&rft.date=2015-10-01&rft.volume=26&rft.issue=12&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462414554433 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 28 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Drug interaction; Data processing; Didanosine; antiretroviral therapy; Lamivudine; Toxicity; Drugs; nucleoside reverse transcriptase inhibitors; Public health; Acquired immune deficiency syndrome; Human immunodeficiency virus; Guidelines; Risk reduction; Antiretroviral agents; Sexually transmitted diseases; Side effects DO - http://dx.doi.org/10.1177/0956462414554433 ER - TY - JOUR T1 - Use of random forest to estimate population attributable fractions from a case-control study of Salmonella enterica serotype Enteritidis infections AN - 1727687549; PQ0002023236 AB - To design effective food safety programmes we need to estimate how many sporadic foodborne illnesses are caused by specific food sources based on case-control studies. Logistic regression has substantive limitations for analysing structured questionnaire data with numerous exposures and missing values. We adapted random forest to analyse data of a case-control study of Salmonella enterica serotype Enteritidis illness for source attribution. For estimation of summary population attributable fractions (PAFs) of exposures grouped into transmission routes, we devised a counterfactual estimator to predict reductions in illness associated with removing grouped exposures. For the purpose of comparison, we fitted the data using logistic regression models with stepwise forward and backward variable selection. Our results show that the forward and backward variable selection of logistic regression models were not consistent for parameter estimation, with different significant exposures identified. By contrast, the random forest model produced estimated PAFs of grouped exposures consistent in rank order with results obtained from outbreak data, with egg-related exposures having the highest estimated PAF (22.1%, 95% confidence interval 8.5-31.8). Random forest might be structurally more coherent and efficient than logistic regression models for attributing Salmonella illnesses to sources involving many causal pathways. JF - Epidemiology and Infection AU - GU, W AU - Vieira, A R AU - Hoekstra, R M AU - Griffin, P M AU - Cole, D AD - Centers for Disease Control and Prevention, Enteric Diseases Epidemiology Branch, Atlanta, GA, USA, vhg8@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 2786 EP - 2794 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 13 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Inventories KW - Data processing KW - Serotypes KW - Food KW - Forests KW - Food contamination KW - Pest outbreaks KW - Infection KW - Food-borne diseases KW - Models KW - Disease transmission KW - Platelet-activating factor KW - Salmonella enterica KW - Food sources KW - Regression analysis KW - Outbreaks KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727687549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Use+of+random+forest+to+estimate+population+attributable+fractions+from+a+case-control+study+of+Salmonella+enterica+serotype+Enteritidis+infections&rft.au=GU%2C+W%3BVieira%2C+A+R%3BHoekstra%2C+R+M%3BGriffin%2C+P+M%3BCole%2C+D&rft.aulast=GU&rft.aufirst=W&rft.date=2015-10-01&rft.volume=143&rft.issue=13&rft.spage=2786&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS095026881500014X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 26 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Platelet-activating factor; Inventories; Serotypes; Data processing; Food; Food sources; Regression analysis; Forests; Infection; Pest outbreaks; Disease transmission; Models; Outbreaks; Food contamination; Food-borne diseases; Salmonella enterica DO - http://dx.doi.org/10.1017/S095026881500014X ER - TY - JOUR T1 - Pneumococcal vaccination coverage among persons greater than or equal to 65 years-United States, 2013 AN - 1727674728; PQ0002170063 AB - Background Invasive pneumococcal disease is a major cause of illness in the United States, and rates are higher among persons greater than or equal to 65 years. Pneumococcal vaccination has been recommended to adults greater than or equal to 65 years since 1997. Methods Data from the 2005-2013 Behavioral Risk Factor Surveillance System were analyzed. Weighted estimates of pneumococcal vaccination coverage were calculated by state and race/ethnicity and tests for linear trend were performed. Results In 2013, the median state vaccination coverage among adults greater than or equal to 65 years was 69.5%, and coverage ranged from 61.9% in New Jersey to 75.6% in Oregon. Coverage overall among non-Hispanic whites (71.1%) was higher than coverage for non-Hispanic blacks (57.7%), Hispanics (51.9%), and non-Hispanic persons of other race (65.4%). Coverage increased from 2005 to 2013 overall and by racial/ethnic subgroups. Conclusion Although pneumococcal vaccination coverage has improved in the past several years, coverage remains below the Healthy People 2020 target of 90% and racial/ethnic disparities exist. JF - Vaccine AU - O'Halloran, Alissa C AU - Lu, Peng-jun AU - Pilishvili, Tamara AD - Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC, 1600 Clifton Road, NE, Mail Stop A 19, Atlanta, GA 30329, United States Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 5503 EP - 5506 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 33 IS - 42 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Pneumococcal vaccination KW - Streptococcus pneumoniae KW - Data processing KW - Risk factors KW - Vaccination KW - Races KW - Ethnic groups KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727674728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupational+lung+cancer+in+US+women%2C+1984-1998.&rft.au=Robinson%2C+Cynthia+F%3BSullivan%2C+Patricia+A%3BLi%2C+Jia%3BWalker%2C+James+T&rft.aulast=Robinson&rft.aufirst=Cynthia&rft.date=2011-02-01&rft.volume=54&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.20905 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 20 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Data processing; Risk factors; Vaccination; Ethnic groups; Races; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/j.vaccine.2015.09.002 ER - TY - JOUR T1 - Network stigma towards people living with HIV/AIDS and their caregivers: an egocentric network study AN - 1721358545; 4713751 AB - HIV stigma occurs among peers in social networks. However, the features of social networks that drive HIV stigma are not well understood. The objective of this study is to investigate anticipated HIV stigma within the social networks of people living with HIV/AIDS (PLWHA) (N = 147) and the social networks of PLWHA's caregivers (N = 148). The egocentric social network data were collected in Guangxi, China. More than half of PLWHA (58%) and their caregivers (53%) anticipated HIV stigma from their network peers. Both PLWHA and their caregivers anticipated that spouses or other family members were less likely to stigmatise them, compared to friend peers or other relationships. Married network peers were believed to stigmatise caregivers more than unmarried peers. The association between frequent contacts and anticipated stigma was negative among caregivers. Being in a close relationship with PLWHA or caregivers (e.g., a spouse or other family member) was associated with less anticipated stigma. Lower network density was associated with higher anticipated stigma among PLWHA's alters, but not among caregivers' alters. Findings may shed light on innovative stigma reduction interventions at the social network level and therefore improve HIV/AIDS treatment utilisation. Reprinted by permission of Taylor & Francis Ltd. JF - Global public health AU - Wu, Fei AU - He, Xin AU - Guida, Jennifer AU - Xu, Yongfang AU - Liu, Hongjie AD - University of Maryland, College Park ; Nanning Center for Disease Control and Prevention Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1032 EP - 1045 VL - 10 IS - 9 SN - 1744-1692, 1744-1692 KW - Sociology KW - Social networks KW - Health care KW - Marital status KW - AIDS KW - Networks KW - HIV KW - Ego KW - Stigma KW - China KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721358545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Global+public+health&rft.atitle=Network+stigma+towards+people+living+with+HIV%2FAIDS+and+their+caregivers%3A+an+egocentric+network+study&rft.au=Wu%2C+Fei%3BHe%2C+Xin%3BGuida%2C+Jennifer%3BXu%2C+Yongfang%3BLiu%2C+Hongjie&rft.aulast=Wu&rft.aufirst=Fei&rft.date=2015-10-01&rft.volume=10&rft.issue=9&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=Global+public+health&rft.issn=17441692&rft_id=info:doi/10.1080%2F17441692.2014.1003572 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-10-12 N1 - Last updated - 2015-10-12 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 12258 11762 11859 11856; 482 3617 6220; 4115; 8634; 7699 7748 6823; 11873 8634; 10449 5772; 5775 13521; 93 116 30 DO - http://dx.doi.org/10.1080/17441692.2014.1003572 ER - TY - JOUR T1 - Severe Acute Respiratory Illness Deaths in Sub-Saharan Africa and the Role of Influenza: A Case Series From 8 Countries AN - 1773833534; PQ0002695538 AB - Background. Data on causes of death due to respiratory illness in Africa are limited. Methods. From January to April 2013, 28 African countries were invited to participate in a review of severe acute respiratory illness (SARI)-associated deaths identified from influenza surveillance during 2009-2012. Results. Twenty-three countries (82%) responded, 11 (48%) collect mortality data, and 8 provided data. Data were collected from 37 714 SARI cases, and 3091 (8.2%; range by country, 5.1%-25.9%) tested positive for influenza virus. There were 1073 deaths (2.8%; range by country, 0.1%-5.3%) reported, among which influenza virus was detected in 57 (5.3%). Case-fatality proportion (CFP) was higher among countries with systematic death reporting than among those with sporadic reporting. The influenza-associated CFP was 1.8% (57 of 3091), compared with 2.9% (1016 of 34 623) for influenza virus-negative cases (P or =50 years. Conclusions. Few African countries systematically collect data on outcomes of people hospitalized with respiratory illness. Stronger surveillance for deaths due to respiratory illness may identify risk groups for targeted vaccine use and other prevention strategies. JF - Journal of Infectious Diseases AU - McMorrow, Meredith L AU - Wemakoy, Emile Okitolonda AU - Tshilobo, Joelle Kabamba AU - Emukule, Gideon O AU - Mott, Joshua A AU - Njuguna, Henry AU - Waiboci, Lilian AU - Heraud, Jean-Michel AU - Rajatonirina, Soatianana AU - Razanajatovo, Norosoa H AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, mmcmorrow@cdc.gov Y1 - 2015/09/15/ PY - 2015 DA - 2015 Sep 15 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 6 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - influenza KW - human KW - mortality KW - Africa South of the Sahara KW - Mortality KW - Data processing KW - Influenza A KW - Adenovirus KW - Pathogens KW - Respiratory syncytial virus KW - Influenza KW - Streptococcus pneumoniae KW - Prevention KW - Influenza virus KW - Infectious diseases KW - Reviews KW - Africa KW - Risk groups KW - Rhinovirus KW - Vaccines KW - Hospitals KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773833534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Severe+Acute+Respiratory+Illness+Deaths+in+Sub-Saharan+Africa+and+the+Role+of+Influenza%3A+A+Case+Series+From+8+Countries&rft.au=McMorrow%2C+Meredith+L%3BWemakoy%2C+Emile+Okitolonda%3BTshilobo%2C+Joelle+Kabamba%3BEmukule%2C+Gideon+O%3BMott%2C+Joshua+A%3BNjuguna%2C+Henry%3BWaiboci%2C+Lilian%3BHeraud%2C+Jean-Michel%3BRajatonirina%2C+Soatianana%3BRazanajatovo%2C+Norosoa+H&rft.aulast=McMorrow&rft.aufirst=Meredith&rft.date=2015-09-15&rft.volume=212&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Influenza A; Risk groups; Pathogens; Vaccines; Influenza; Prevention; Infectious diseases; Reviews; Hospitals; Respiratory syncytial virus; Streptococcus pneumoniae; Influenza virus; Adenovirus; Rhinovirus; Africa DO - http://dx.doi.org/10.1093/infdis/jiv100 ER - TY - JOUR T1 - Multinational Disease Surveillance Programs: Promoting Global Information Exchange for Infectious Diseases AN - 1827924434; PQ0003669087 AB - Cross-border surveillance for emerging diseases such as Ebola and other infectious diseases requires effective international collaboration. We surveyed representatives from 12 multinational disease surveillance programs between January 2013 and April 2014. Our survey identified programmatic similarities despite variation in health priorities, geography, and socioeconomic context, providing a contemporary perspective on infectious disease surveillance networks. JF - American Journal of Tropical Medicine and Hygiene AU - Varan, Aiden K AU - Bruniera-Oliveira, Robson AU - Peter, Christopher R AU - Fonseca-Ford, Maureen AU - Waterman, Stephen H AD - CDC/CSTE Applied Epidemiology Fellowship, Council of State and Territorial Epidemiologists, Atlanta, Georgia, shw2@cdc.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 668 EP - 671 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 3 SN - 0002-9637, 0002-9637 KW - Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Socio-economic aspects KW - Infectious diseases KW - Viruses KW - Socioeconomics KW - Priorities KW - Geography KW - International agreements KW - Information exchange KW - K 03490:Miscellaneous KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827924434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Multinational+Disease+Surveillance+Programs%3A+Promoting+Global+Information+Exchange+for+Infectious+Diseases&rft.au=Varan%2C+Aiden+K%3BBruniera-Oliveira%2C+Robson%3BPeter%2C+Christopher+R%3BFonseca-Ford%2C+Maureen%3BWaterman%2C+Stephen+H&rft.aulast=Varan&rft.aufirst=Aiden&rft.date=2015-09-01&rft.volume=93&rft.issue=3&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Socio-economic aspects; Infectious diseases; Geography; Viruses; Priorities; Socioeconomics; International agreements; Information exchange DO - http://dx.doi.org/10.4269/ajtmh.15-0097 ER - TY - JOUR T1 - Medical and Indirect Costs Associated with a Rocky Mountain Spotted Fever Epidemic in Arizona, 2002-2011 AN - 1827886906; PQ0003669070 AB - Rocky Mountain spotted fever (RMSF) is an emerging public health issue on some American Indian reservations in Arizona. RMSF causes an acute febrile illness that, if untreated, can cause severe illness, permanent sequelae requiring lifelong medical support, and death. We describe costs associated with medical care, loss of productivity, and death among cases of RMSF on two American Indian reservations (estimated population 20,000) between 2002 and 2011. Acute medical costs totaled more than $1.3 million. This study further estimated $181,100 in acute productivity lost due to illness, and $11.6 million in lifetime productivity lost from premature death. Aggregate costs of RMSF cases in Arizona 2002-2011 amounted to $13.2 million. We believe this to be a significant underestimate of the cost of the epidemic, but it underlines the severity of the disease and need for a more comprehensive study. JF - American Journal of Tropical Medicine and Hygiene AU - Drexler, Naomi A AU - Traeger, Marc S AU - McQuiston, Jennifer H AU - Williams, Velda AU - Hamilton, Charlene AU - Regan, Joanna J AD - Rickettsial Zoonoses Branch, Division of Vector-borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, isj3@cdc.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 549 EP - 551 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 3 SN - 0002-9637, 0002-9637 KW - Health & Safety Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - North America, Rocky Mts. KW - Mountains KW - Mortality KW - Rocky Mountain spotted fever KW - Epidemics KW - Complications KW - USA, Arizona KW - Public health KW - K 03400:Human Diseases KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Medical+and+Indirect+Costs+Associated+with+a+Rocky+Mountain+Spotted+Fever+Epidemic+in+Arizona%2C+2002-2011&rft.au=Drexler%2C+Naomi+A%3BTraeger%2C+Marc+S%3BMcQuiston%2C+Jennifer+H%3BWilliams%2C+Velda%3BHamilton%2C+Charlene%3BRegan%2C+Joanna+J&rft.aulast=Drexler&rft.aufirst=Naomi&rft.date=2015-09-01&rft.volume=93&rft.issue=3&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Rocky Mountain spotted fever; Epidemics; Complications; Public health; Mountains; Mortality; North America, Rocky Mts.; USA, Arizona DO - http://dx.doi.org/10.4269/ajtmh.15-0104 ER - TY - JOUR T1 - Three months of weekly rifapentine plus isoniazid is less hepatotoxic than nine months of daily isoniazid for LTBI AN - 1732810219; PQ0002041452 AB - SETTING: Nine months of daily isoniazid (9H) and 3 months of once-weekly rifapentine plus isoniazid (3HP) are recommended treatments for latent tuberculous infection (LTBI). The risk profile for 3HP and the contribution of hepatitis C virus (HCV) infection to hepatotoxicity are unclear. OBJECTIVES: To evaluate the hepatotoxicity risk associated with 3HP compared to 9H, and factors associated with hepatotoxicity DESIGN: Hepatotoxicity was defined as aspartate aminotransferase (AST) >3 times the upper limit of normal (ULN) with symptoms (nausea, vomiting, jaundice, or fatigue), or AST >5 x ULN. We analyzed risk factors among adults who took at least 1 dose of their assigned treatment. A nested case-control study assessed the role of HCV. RESULTS: Of 6862 participants, 77 (1.1%) developed hepatotoxicity; 52 (0.8%) were symptomatic; 1.8% (61/3317) were on 9H and 0.4% (15/3545) were on 3HP (P < 0.0001). Risk factors for hepatotoxicity were age, female sex, white race, non-Hispanic ethnicity, decreased body mass index, elevated baseline AST, and 9H. In the case-control study, HCV infection was associated with hepatotoxicity when controlling for other factors. CONCLUSION: The risk of hepatotoxicity during LTBI treatment with 3HP was lower than the risk with 9H. HCV and elevated baseline AST were risk factors for hepatotoxicity. For persons with these risk factors, 3HP may be preferred. JF - International Journal of Tuberculosis and Lung Disease AU - Bliven-Sizemore, E E AU - Sterling, T R AU - Shang, N AU - Benator, D AU - Schwartzman, K AU - Reves, R AU - Drobeniuc, J AU - Bock, N AU - Villarino, M E AD - Division of Tuberculosis Elimination, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, esizemore@cdc.gov PY - 2015 SP - 1039 EP - 1044 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 9 SN - 1027-3719, 1027-3719 KW - Health & Safety Science Abstracts; Risk Abstracts KW - isoniazid KW - hepatitis C KW - aspartate aminotransferases KW - Risk assessment KW - Age KW - Fatigue KW - Mycobacterium KW - Body mass KW - Infection KW - Lung KW - Risk factors KW - Tuberculosis KW - Hepatitis C KW - Hepatotoxicity KW - Ethnic groups KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732810219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Three+months+of+weekly+rifapentine+plus+isoniazid+is+less+hepatotoxic+than+nine+months+of+daily+isoniazid+for+LTBI&rft.au=Bliven-Sizemore%2C+E+E%3BSterling%2C+T+R%3BShang%2C+N%3BBenator%2C+D%3BSchwartzman%2C+K%3BReves%2C+R%3BDrobeniuc%2C+J%3BBock%2C+N%3BVillarino%2C+M+E&rft.aulast=Bliven-Sizemore&rft.aufirst=E&rft.date=2015-09-01&rft.volume=19&rft.issue=9&rft.spage=1039&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0829 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Risk assessment; Age; Fatigue; Lung; Body mass; Risk factors; Tuberculosis; Hepatitis C; Infection; Hepatotoxicity; Ethnic groups; Mycobacterium DO - http://dx.doi.org/10.5588/ijtld.14.0829 ER - TY - JOUR T1 - Comparison of the deratization effect between two methods of poison bait box and scattered poison bait AN - 1842511740; PQ0002658850 AB - The objective of this paper is to compare the deratization effect between two methods of poison bait box and scattered poison bait. The field tests were carried out in Sujia, Guo jia, Xicaishi, Guoheitun and Liuheitun village of Linyi city and Jinan city. In Sujia villageone box with 0.05% diphacine-Na bait was placed in every two rooms; while in Guojia village, the bait was scattered in every room. In Xicaishi village, one box with 0.05% diphacine-Na wheat was placed in every room. In Guoheitun and Liuhei tun villages, 3-5 piles of 0.05% diphacine-Na mixed poison baits poison bait weighted 5-10 g were scattered in every room for four days. The powder p late method was employed to evaluate the deratization effect. The method of poison bait box is an important technical means on the sustainable control of population density of rodents. JF - Chinese Journal of Hygienic Insecticides & Equipment AU - Gong, Xue-shi AU - Liu, Yong AU - Qu, Bao-quan AU - Zhang, Shi-shui AU - Jing, Xiao AU - Wang, Xue-jun AU - Liu, Feng AU - Zhao, Zhi-gang AU - Fu, Ying AU - Zhang, Kui-wei AD - Shandong Provincial Center for Disease Control and Prevention Y1 - 2015/08// PY - 2015 DA - August 2015 PB - Editorial Department of the Chinese Journal of Hygienic Insecticides & Equipment, 293 Zhongshan East Road Nanjing, Jiangsu Province, 210002 China VL - 21 IS - 4 SN - 1671-2781, 1671-2781 KW - Toxicology Abstracts KW - poison bait box method KW - scattered poison bai method KW - diphacine-Na KW - deratization effect KW - Triticum aestivum KW - Powder KW - Insecticides KW - Population density KW - Hygiene KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842511740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.atitle=Comparison+of+the+deratization+effect+between+two+methods+of+poison+bait+box+and+scattered+poison+bait&rft.au=Gong%2C+Xue-shi%3BLiu%2C+Yong%3BQu%2C+Bao-quan%3BZhang%2C+Shi-shui%3BJing%2C+Xiao%3BWang%2C+Xue-jun%3BLiu%2C+Feng%3BZhao%2C+Zhi-gang%3BFu%2C+Ying%3BZhang%2C+Kui-wei&rft.aulast=Gong&rft.aufirst=Xue-shi&rft.date=2015-08-01&rft.volume=21&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.issn=16712781&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Powder; Insecticides; Population density; Hygiene; Triticum aestivum ER - TY - JOUR T1 - Investigation and analysis of important medical vectors and vector-borne diseases in military camps in Shandong AN - 1768577370; PQ0002658873 AB - Objective To investigate the population density of important medical vectors and the potential of vectorborne diseases in military camps in Shandong. Methods Population density investigating of rodent, mosquitoes, flies and cockroaches was carried out based on the book "Disinsection and Deratization". Risk evaluation of vectorborne diseases was carried out according to investigating results. Results The captured rodentia belonged to 9 species, 5 genus, 3 families; mosquitoes 19 species, 5 genus; flies 122 species, 50 genus, 4 families; cockroaches 3 species. Rattus Norvegicus was the dominant species of rodent. The highest rodent density appeared in the hotels. Anopheles sinensis, Culex pipiens pallens and Aedes Albopictus existed in all camps investigated. Blattela germanica was the dominant cockroach species. Seven vector-borne diseases occured from 2005, and hemorrhagic fever with renal syndrome, malaria and inundation fever were the top three. Conclusion The risk of hemorrhagic fever with renal syndrome is high in camps of rural. JF - Chinese Journal of Hygienic Insecticides & Equipment AU - Zhou, Guang-zhi AU - Wen, Yu AU - Liu, Yuan-dong AU - Huang, Wei-chu AU - Wang, Zhi AU - He, Ying AU - Yin, Guang-qing AD - Center for Disease Control and Prevention of Jinan Command Y1 - 2015/08// PY - 2015 DA - August 2015 PB - Editorial Department of the Chinese Journal of Hygienic Insecticides & Equipment, 293 Zhongshan East Road Nanjing, Jiangsu Province, 210002 China VL - 21 IS - 4 SN - 1671-2781, 1671-2781 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - military camp KW - vector KW - vector-borne diseases KW - risk evaluation KW - Symptoms KW - Hemorrhagic fever with renal syndrome KW - Culex pipiens pallens KW - Vector-borne diseases KW - Population density KW - Malaria KW - Hosts KW - Public health KW - Disease transmission KW - Fever KW - Insecticides KW - Aquatic insects KW - Cyclic AMP KW - Vectors KW - Aedes albopictus KW - Rattus norvegicus KW - Dominant species KW - Books KW - Anopheles sinensis KW - Rodentia KW - Hygiene KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768577370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.atitle=Investigation+and+analysis+of+important+medical+vectors+and+vector-borne+diseases+in+military+camps+in+Shandong&rft.au=Zhou%2C+Guang-zhi%3BWen%2C+Yu%3BLiu%2C+Yuan-dong%3BHuang%2C+Wei-chu%3BWang%2C+Zhi%3BHe%2C+Ying%3BYin%2C+Guang-qing&rft.aulast=Zhou&rft.aufirst=Guang-zhi&rft.date=2015-08-01&rft.volume=21&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.issn=16712781&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Dominant species; Symptoms; Insecticides; Population density; Vectors; Hosts; Aquatic insects; Disease transmission; Public health; Fever; Hemorrhagic fever with renal syndrome; Books; Vector-borne diseases; Cyclic AMP; Malaria; Hygiene; Culex pipiens pallens; Anopheles sinensis; Rodentia; Aedes albopictus; Rattus norvegicus ER - TY - JOUR T1 - RE-TESTING AND SEROCONVERSION AMONG HIV TESTING AND COUNSELING CLIENTS IN LESOTHO AN - 1727696188; PQ0002160750 AB - HIV testing and counseling (HTC) is an essential component of comprehensive HIV programs. Retrospective HTC program data from 2006 to 2010 were examined to determine patterns of re-testing and seroconversion in Lesotho. Among 104,662 initially negative clients, 6,777 (6.5%) were re-testers. Predictors of re-testing included being male, age [> or =] 25 years, divorced/separated, having more than a high school education, being tested as a couple, testing in the year 2006, testing in the capital city, and awareness of partner's recent testing behavior. Among re-testers who seroconverted (N = 259), predictors included being female and having less than a high school education. There is a critical need for more effectively targeting HIV re-testing messages to align with WHO (2010) guidelines and identify persons at highest risk for HIV, to increase timely diagnoses and link persons to appropriate HIV prevention, care, and treatment services. JF - AIDS Education and Prevention AU - Grabbe, Kristina L AU - Courtenay-Quirk, Cari AU - Baughman, Andrew L AU - Djomand, Gaston AU - Pedersen, Brian AU - Lerotholi, Mankhala AU - Nkonyana, John AU - Ramphalla-Phatela, Puleng AU - Marum, Elizabeth AD - Division of Global HIV/AIDS, Centers for Disease Control and Prevention, Atlanta, Georgia, ccourtenayquirk@cdc.gov Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 350 EP - 361 PB - Guilford Publications, Inc., 72 Spring Street, 4th Floor New York NY 10012 United States VL - 27 IS - 4 SN - 0899-9546, 0899-9546 KW - Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Age KW - Data processing KW - Guidelines KW - Lesotho KW - Education KW - Prevention KW - Behavior KW - Human immunodeficiency virus KW - Risk factors KW - Seroconversion KW - Urban areas KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727696188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Education+and+Prevention&rft.atitle=RE-TESTING+AND+SEROCONVERSION+AMONG+HIV+TESTING+AND+COUNSELING+CLIENTS+IN+LESOTHO&rft.au=Grabbe%2C+Kristina+L%3BCourtenay-Quirk%2C+Cari%3BBaughman%2C+Andrew+L%3BDjomand%2C+Gaston%3BPedersen%2C+Brian%3BLerotholi%2C+Mankhala%3BNkonyana%2C+John%3BRamphalla-Phatela%2C+Puleng%3BMarum%2C+Elizabeth&rft.aulast=Grabbe&rft.aufirst=Kristina&rft.date=2015-08-01&rft.volume=27&rft.issue=4&rft.spage=350&rft.isbn=&rft.btitle=&rft.title=AIDS+Education+and+Prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Risk factors; Seroconversion; Acquired immune deficiency syndrome; Prevention; Education; Behavior; Human immunodeficiency virus; Guidelines; Urban areas; Lesotho ER - TY - JOUR T1 - Population Size Estimates for Men who Have Sex with Men and Persons who Inject Drugs AN - 1712771368; PQ0001920715 AB - Understanding geographic variation in the numbers of men who have sex with men (MSM) and persons who inject drugs (PWID) is critical to targeting and scaling up HIV prevention programs, but population size estimates are not available at generalizable sub-national levels. We analyzed 1999-2010 National Health and Nutrition Examination Survey data on persons aged 18-59 years. We estimated weighted prevalence of recent (past 12 month) male-male sex and injection drug use by urbanicity (the degree to which a geographic area is urban) and US census region and calculated population sizes. Large metro areas (population greater than or equal to 1,000,000) had higher prevalence of male-male sex (central areas, 4.4 % of men; fringe areas, 2.5 %) compared with medium/small metro areas (1.4 %) and nonmetro areas (1.1 %). Injection drug use did not vary by urbanicity and neither varied by census region. Three-quarters of MSM, but only half of PWID, resided in large metro areas. Two-thirds of MSM and two-thirds of PWID resided in the South and West. Efforts to reach MSM would benefit from being focused in large metro areas, while efforts to reach PWID should be delivered more broadly. These data allow for more effective allocation of funds for prevention programs. JF - Journal of Urban Health AU - Oster, Alexandra M AU - Sternberg, Maya AU - Lansky, Amy AU - Broz, Dita AU - Wejnert, Cyprian AU - Paz-Bailey, Gabriela AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Centers for Disease Control and Prevention, Atlanta, GA, USA, aoster@cdc.gov Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 733 EP - 743 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 92 IS - 4 SN - 1099-3460, 1099-3460 KW - Health & Safety Science Abstracts KW - Prevention KW - Funds KW - Human immunodeficiency virus KW - Census KW - Homosexuality KW - Drug abuse KW - Drugs KW - Nutrition KW - Scaling KW - Population number KW - Urban areas KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712771368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urban+Health&rft.atitle=Population+Size+Estimates+for+Men+who+Have+Sex+with+Men+and+Persons+who+Inject+Drugs&rft.au=Oster%2C+Alexandra+M%3BSternberg%2C+Maya%3BLansky%2C+Amy%3BBroz%2C+Dita%3BWejnert%2C+Cyprian%3BPaz-Bailey%2C+Gabriela&rft.aulast=Oster&rft.aufirst=Alexandra&rft.date=2015-08-01&rft.volume=92&rft.issue=4&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urban+Health&rft.issn=10993460&rft_id=info:doi/10.1007%2Fs11524-015-9970-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 15 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Funds; Prevention; Human immunodeficiency virus; Census; Homosexuality; Drug abuse; Scaling; Nutrition; Drugs; Urban areas; Population number DO - http://dx.doi.org/10.1007/s11524-015-9970-3 ER - TY - JOUR T1 - Trends in use of genotypic resistance testing and frequency of major drug resistance among antiretroviral-naive persons in the HIV Outpatient Study, 1999-2011 AN - 1712563949; PQ0001944576 AB - Background Monitoring antiretroviral drug resistance can inform treatment recommendations; however, there are few such data from US patients before they initiate ART. Methods We analysed data from HIV Outpatient Study (HOPS) participants from nine US HIV clinics who were diagnosed with HIV infection during 1999-2011. Using the IAS-USA December 2010 guidelines, we assessed the frequency of major drug resistance mutations (mDRMs) related to antiretroviral agents in viral isolates from patients who underwent commercial genotypic testing (GT) for resistance before initiating ART. We employed general linear regression models to assess factors associated with having undergone GT, and then factors associated with having mDRM. Results Among 1531 eligible patients, 758 (49.5%) underwent GT before first ART, increasing from 15.5% in 1999-2002 to 75.9% in 2009-11 (P5.0 log sub(10) copies/mL and those with a first HOPS visit in 2006 or later were significantly (P<0.05) more likely to have undergone GT. Of the 758 patients, 114 (15.0%) had mDRMs; mutations relating to NRTIs, NNRTIs and PIs were present in 8.0%, 7.1% and 2.6%, respectively. There was no temporal change in the frequency of mDRM, and mDRMs were associated with an HIV RNA level <4.0 log sub(10) copies/mL. Conclusions During 1999-2011, GT use among antiretroviral-naive patients became more common, but a quarter of patients in recent years remained untested. The frequency of mDRMs remained stable over time at about 15%. JF - Journal of Antimicrobial Chemotherapy AU - Buchacz, Kate AU - Young, Benjamin AU - Palella, Frank J AU - Armon, Carl AU - Brooks, John T Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2337 EP - 2346 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 8 SN - 0305-7453, 0305-7453 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - HIV infection KW - genotype KW - mutation KW - epidemiology KW - primary KW - transmitted KW - Data processing KW - Drug resistance KW - antiretroviral therapy KW - Infection KW - hops KW - CD4 antigen KW - RNA KW - Antiviral agents KW - Human immunodeficiency virus KW - antiretroviral agents KW - Regression analysis KW - Lymphocytes T KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712563949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Trends+in+use+of+genotypic+resistance+testing+and+frequency+of+major+drug+resistance+among+antiretroviral-naive+persons+in+the+HIV+Outpatient+Study%2C+1999-2011&rft.au=Buchacz%2C+Kate%3BYoung%2C+Benjamin%3BPalella%2C+Frank+J%3BArmon%2C+Carl%3BBrooks%2C+John+T&rft.aulast=Buchacz&rft.aufirst=Kate&rft.date=2015-08-01&rft.volume=70&rft.issue=8&rft.spage=2337&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Data processing; Antiviral agents; RNA; Drug resistance; antiretroviral agents; antiretroviral therapy; Lymphocytes T; Regression analysis; Infection; Mutation; hops; Human immunodeficiency virus DO - http://dx.doi.org/10.1093/jac/dkv120 ER - TY - JOUR T1 - Maternal exposures in the National Birth Defects Prevention Study: Time trends of selected exposures AN - 1709189610; PQ0001901227 AB - Background Our objective was to describe time trends in selected pregnancy exposures in the National Birth Defects Prevention Study (NBDPS). Methods We analyzed data from the NBDPS, a multi-site case-control study of major birth defects, for mothers of live-born infants without birth defects (controls), with an expected date of delivery (EDD) from 1998 to 2011. Mothers from the 10 participating centers across the United States were interviewed by phone between 6 weeks and 2 years after the EDD. We focused on maternal race/ethnicity and five maternal risk factors: obesity, use of folic acid-containing multivitamins, opioid analgesics, selective serotonin reuptake inhibitors, and loratadine because of their prevalence of use and some reports of associations with major birth defects. Prevalence time trends were examined using the Kendall's tau sub( beta ) test statistic. Results The exposure trend analysis included 11,724 control mothers with EDDs from 1998 to 2011. We observed a significant increase in obesity prevalence among control mothers, as well as use of selective serotonin reuptake inhibitors and loratadine. We also observed an increase in periconceptional use of folic acid-containing multivitamins. Some of the time trends varied by race/ethnicity. No remarkable trend in the overall use of opioid analgesics was observed. The racial/ethnic distribution of mothers changed slightly during the study period. Conclusion Long-term, population-based case-control studies continue to be an effective way to assess exposure-birth defects associations and provide guidance to health care providers. However, investigators examining rare outcomes covering many years of data collection need to be cognizant of time trends in exposures. Birth Defects Research (Part A) 103:703-712, 2015. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Dawson, April L AU - Razzaghi, Hilda AU - Arth, Annelise AU - Canfield, Mark A AU - Parker, Samantha E AU - Reefhuis, Jennita AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 703 EP - 712 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 8 SN - 1542-0752, 1542-0752 KW - Toxicology Abstracts KW - Obesity KW - Data processing KW - Serotonin uptake inhibitors KW - Data collections KW - Pregnancy KW - Risk factors KW - Congenital defects KW - Opioids KW - Analgesics KW - Ethnic groups KW - Races KW - Infants KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709189610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Maternal+exposures+in+the+National+Birth+Defects+Prevention+Study%3A+Time+trends+of+selected+exposures&rft.au=Dawson%2C+April+L%3BRazzaghi%2C+Hilda%3BArth%2C+Annelise%3BCanfield%2C+Mark+A%3BParker%2C+Samantha+E%3BReefhuis%2C+Jennita&rft.aulast=Dawson&rft.aufirst=April&rft.date=2015-08-01&rft.volume=103&rft.issue=8&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Obesity; Data processing; Risk factors; Serotonin uptake inhibitors; Congenital defects; Opioids; Data collections; Analgesics; Races; Ethnic groups; Pregnancy; Infants DO - http://dx.doi.org/10.1002/bdra.23377 ER - TY - JOUR T1 - Injury Prevention Practices as Depicted in G- and PG-Rated Movies, 2008-2012 AN - 1709179071; PQ0001870527 AB - Unintentional injuries are the leading cause of death among children in the United States. The use of recommended safety practices can reduce injuries. Children often learn behaviors from media exposure. Children's movies released in 1995-2007 infrequently depicted appropriate injury prevention practices. The aim of this study was to determine if injury prevention practices in children's movies have improved. The top grossing 25 G- and PG-rated movies in the United States per year for 2008-2012 were eligible for inclusion in the study. Movies or scenes were excluded if they were animated, not set in the present day, fantasy, documentary, or not in English. Injury prevention practices involving riding in a motor vehicle, walking, boating, bicycling, and four other activities were recorded for characters with speaking roles. Fifty-six (45 %) of the 125 movies met the inclusion criteria. A total of 603 person-scenes were examined involving 175 (29 %) children and 428 (71 %) adults. Thirty-eight person-scenes involved crashes or falls, resulting in four injuries and no deaths. Overall, 59 % (353/603) of person-scenes showed appropriate injury prevention practices. This included 313 (70 %) of 445 motor-vehicle passengers who were belted; 15 (30 %) of 50 pedestrians who used a crosswalk, 2 (7 %) of 30 boaters who wore personal flotation devices, and 8 (29 %) of 28 bicyclists who wore helmets. In comparison with previous studies, there were significant increases in usage of seat belts, crosswalks, personal flotation devices, and bicycle helmets. However, 41 % of person-scenes still showed unsafe practices and the consequences of those behaviors were infrequently depicted. JF - Journal of Community Health AU - Pelletier, Andrew R AU - Tongren, JEric AU - Gilchrist, Julie AD - Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA, arp1@cdc.gov Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 613 EP - 618 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 4 SN - 0094-5145, 0094-5145 KW - Health & Safety Science Abstracts KW - Mortality KW - Seat belts KW - Injuries KW - Helmets KW - Pedestrians KW - Motor vehicles KW - Safety KW - Children KW - Protective equipment KW - USA KW - Accidents KW - Prevention KW - Bicycles KW - Behavior KW - Flotation KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709179071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Injury+Prevention+Practices+as+Depicted+in+G-+and+PG-Rated+Movies%2C+2008-2012&rft.au=Pelletier%2C+Andrew+R%3BTongren%2C+JEric%3BGilchrist%2C+Julie&rft.aulast=Pelletier&rft.aufirst=Andrew&rft.date=2015-08-01&rft.volume=40&rft.issue=4&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-014-9974-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 31 N1 - Last updated - 2015-09-17 N1 - SubjectsTermNotLitGenreText - Mortality; Seat belts; Injuries; Helmets; Motor vehicles; Pedestrians; Safety; Children; Protective equipment; Prevention; Accidents; Bicycles; Behavior; Flotation; USA DO - http://dx.doi.org/10.1007/s10900-014-9974-z ER - TY - JOUR T1 - Next steps for birth defects research and prevention: The birth defects study to evaluate pregnancy exposures (BD-STEPS) AN - 1709176513; PQ0001901226 AB - Background The Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS) is a population-based, multi-Center case-control study of modifiable risk factors for selected birth defects in the United States. BD-STEPS is the second major research effort of the Centers for Birth Defects Research and Prevention, which extends and expands the initial research effort, the National Birth Defects Prevention Study (NBDPS). Methods BD-STEPS focuses on 17 categories of structural birth defects selected based on severity, prevalence, consistent ascertainment, and previous findings that warrant additional research. Cases are identified through existing birth defects surveillance programs; controls are from vital records or birth hospital logs from the same catchment area. BD-STEPS uses a standardized computer-assisted telephone interview to collect information from case and control mothers on topics including demographics, health conditions, and medication use. Following the maternal interview, selected Centers request permission to sample residual newborn screening blood spots from state repositories for genetic analyses. New components planned for BD-STEPS include linkages with external datasets and use of online questionnaires to collect in-depth information on selected exposures. Results BD-STEPS extends NBDPS by continuing to collect data on many exposures that were assessed in NBDPS, allowing data from both studies to be combined and providing an unprecedented sample size to analyze rare exposures. BD-STEPS expands upon NBDPS by collecting more detailed information on existing exposures as well as new exposures. Conclusion The goal of BD-STEPS is to provide women and healthcare providers with information they need to make decisions to promote the healthiest pregnancy possible. Birth Defects Research (Part A) 103:733-740, 2015. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Tinker, Sarah C AU - Carmichael, Suzan L AU - Anderka, Marlene AU - Browne, Marilyn L AU - Caspers Conway, Kristin M AU - Meyer, Robert E AU - Nembhard, Wendy N AU - Olney, Richard S AU - Reefhuis, Jennita AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 733 EP - 740 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 8 SN - 1542-0752, 1542-0752 KW - Toxicology Abstracts KW - Inventories KW - Data processing KW - Genetic analysis KW - Pregnancy KW - Birth KW - Demography KW - Decision making KW - Blood KW - Catchment areas KW - Risk factors KW - Congenital defects KW - Neonates KW - Internet KW - Hospitals KW - X 24500:Reviews, Legislation, Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709176513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Next+steps+for+birth+defects+research+and+prevention%3A+The+birth+defects+study+to+evaluate+pregnancy+exposures+%28BD-STEPS%29&rft.au=Tinker%2C+Sarah+C%3BCarmichael%2C+Suzan+L%3BAnderka%2C+Marlene%3BBrowne%2C+Marilyn+L%3BCaspers+Conway%2C+Kristin+M%3BMeyer%2C+Robert+E%3BNembhard%2C+Wendy+N%3BOlney%2C+Richard+S%3BReefhuis%2C+Jennita&rft.aulast=Tinker&rft.aufirst=Sarah&rft.date=2015-08-01&rft.volume=103&rft.issue=8&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23373 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Inventories; Data processing; Genetic analysis; Pregnancy; Demography; Birth; Blood; Decision making; Catchment areas; Risk factors; Congenital defects; Neonates; Internet; Hospitals DO - http://dx.doi.org/10.1002/bdra.23373 ER - TY - JOUR T1 - Nicotine and the Developing Human: A Neglected Element in the Electronic Cigarette Debate. AN - 1697751740; 25794473 AB - The elimination of cigarettes and other combusted tobacco products in the U.S. would prevent tens of millions of tobacco-related deaths. It has been suggested that the introduction of less harmful nicotine delivery devices, such as electronic cigarettes or other electronic nicotine delivery systems, will accelerate progress toward ending combustible cigarette use. However, careful consideration of the potential adverse health effects from nicotine itself is often absent from public health debates. Human and animal data support that nicotine exposure during periods of developmental vulnerability (fetal through adolescent stages) has multiple adverse health consequences, including impaired fetal brain and lung development, and altered development of cerebral cortex and hippocampus in adolescents. Measures to protect the health of pregnant women and children are needed and could include (1) strong prohibitions on marketing that increase youth uptake; (2) youth access laws similar to those in effect for other tobacco products; (3) appropriate health warnings for vulnerable populations; (4) packaging to prevent accidental poisonings; (5) protection of non-users from exposure to secondhand electronic cigarette aerosol; (6) pricing that helps minimize youth initiation and use; (7) regulations to reduce product addiction potential and appeal for youth; and (8) the age of legal sale. Published by Elsevier Inc. JF - American journal of preventive medicine AU - England, Lucinda J AU - Bunnell, Rebecca E AU - Pechacek, Terry F AU - Tong, Van T AU - McAfee, Tim A AD - Office on Smoking and Health. Electronic address: lbe9@cdc.gov. ; Office on Smoking and Health. ; Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 286 EP - 293 VL - 49 IS - 2 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - United States KW - Animals KW - Public Health KW - Commerce -- legislation & jurisprudence KW - Tobacco Products -- supply & distribution KW - Humans KW - Child KW - Tobacco Products -- adverse effects KW - Adolescent KW - Female KW - Pregnancy KW - Nicotine -- adverse effects KW - Electronic Cigarettes -- adverse effects KW - Smoking -- adverse effects KW - Smoking -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697751740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=Nicotine+and+the+Developing+Human%3A+A+Neglected+Element+in+the+Electronic+Cigarette+Debate.&rft.au=England%2C+Lucinda+J%3BBunnell%2C+Rebecca+E%3BPechacek%2C+Terry+F%3BTong%2C+Van+T%3BMcAfee%2C+Tim+A&rft.aulast=England&rft.aufirst=Lucinda&rft.date=2015-08-01&rft.volume=49&rft.issue=2&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=1873-2607&rft_id=info:doi/10.1016%2Fj.amepre.2015.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2005 Jan;113(1):98-103 [15626655] Toxicology. 2005 May 5;209(3):245-61 [15795061] Chest. 2005 Apr;127(4):1232-41 [15821200] Epidemiology. 2006 Jan;17(1):47-51 [16357594] Paediatr Perinat Epidemiol. 2006 Mar;20(2):90-9 [16466427] AAPS J. 2005;7(4):E885-94 [16594641] J Health Psychol. 2007 Mar;12(2):215-24 [17284486] Psychopharmacology (Berl). 2007 Mar;191(1):159-69 [16937098] Obstet Gynecol. 2011 Sep;118(3):746-50 [21860316] Neurobiol Learn Mem. 2014 Jan;107:108-32 [23973448] JAMA. 2014 Jan 8;311(2):135-6 [24399548] Behav Neurosci. 2007 Dec;121(6):1342-52 [18085887] Environ Health Perspect. 2011 Sep;119(9):1218-26 [21628107] Tob Control. 2011 Nov;20(6):425-6 [21659450] Pediatrics. 2011 Sep;128(3):503-9 [21873701] MMWR Morb Mortal Wkly Rep. 2014 Sep 5;63(35):765-9 [25188494] J Adolesc Health. 2014 Nov;55(5):713-5 [25344033] MMWR Morb Mortal Wkly Rep. 2014 Nov 14;63(45):1021-6 [25393220] Environ Res. 2014 Nov;135:76-80 [25262078] Nicotine Tob Res. 2015 Feb;17(2):228-35 [25143298] Nicotine Tob Res. 2015 Feb;17(2):256-8 [25173774] Nicotine Tob Res. 2015 Feb;17(2):219-27 [25239961] Neurotoxicol Teratol. 2008 Jan-Feb;30(1):1-19 [18380035] Birth Defects Res C Embryo Today. 2008 Mar;84(1):30-44 [18383130] Br J Pharmacol. 2008 Aug;154(8):1558-71 [18500366] Eur J Epidemiol. 2012 Apr;27(4):297-304 [22430122] Cold Spring Harb Perspect Med. 2012 Dec;2(12):a012120 [22983224] Inhal Toxicol. 2013 Feb;25(2):91-101 [23363041] BMC Med. 2012;10:129 [23106849] BMC Med. 2013;11:27 [23379695] Public Health Rep. 2013 May-Jun;128(3):179-88 [23633733] Prev Chronic Dis. 2013;10:E79 [23680508] MMWR Morb Mortal Wkly Rep. 2013 Sep 6;62(35):729-30 [24005229] Ann Epidemiol. 2013 Oct;23(10):652-61 [23969303] Harm Reduct J. 2013;10:19 [24090432] PLoS One. 2013;8(10):e79332 [24250756] Addict Behav. 2014 Mar;39(3):507-11 [24290207] Am J Public Health. 2014 Feb;104 Suppl 1:S43-8 [24354819] MMWR Morb Mortal Wkly Rep. 2014 Apr 4;63(13):292-3 [24699766] Circulation. 2014 May 13;129(19):1972-86 [24821826] Int J Hyg Environ Health. 2014 Jul;217(6):628-37 [24373737] Pediatrics. 2014 Jul;134(1):e29-36 [24918224] N Engl J Med. 2014 Sep 4;371(10):932-43 [25184865] Am J Prev Med. 2008 Oct;35(4):327-33 [18779027] Neuropharmacology. 2009;56 Suppl 1:263-78 [18723034] Physiol Rev. 2009 Jan;89(1):73-120 [19126755] Neurosci Biobehav Rev. 2009 Mar;33(3):367-82 [19028521] Nat Rev Neurosci. 2009 Apr;10(4):303-12 [19277053] Pharmacol Ther. 2009 May;122(2):125-39 [19268688] Biochem Pharmacol. 2009 Oct 1;78(7):668-76 [19426718] Am J Prev Med. 2010 Jul;39(1):45-52 [20547278] Epidemiology. 2010 Nov;21(6):772-8 [20805750] Neuropsychopharmacology. 2011 Jan;36(1):356-7 [21116249] Int J Environ Res Public Health. 2011 Mar;8(3):875-98 [21556184] Brain Res. 2000 Oct 13;880(1-2):167-72 [11033001] Brain Res. 2001 Apr 27;899(1-2):94-100 [11311869] J Am Acad Child Adolesc Psychiatry. 2001 Sep;40(9):1012-20 [11556624] Am J Respir Crit Care Med. 2001 Sep 15;164(6):989-94 [11587984] Am J Respir Cell Mol Biol. 2002 Jan;26(1):31-41 [11751201] Respirology. 2003 Sep;8(3):266-85 [14528876] Behav Brain Res. 2004 Apr 2;150(1-2):159-70 [15033289] BMJ. 2004 Jun 26;328(7455):1538 [15198947] Ann N Y Acad Sci. 2004 Jun;1021:77-85 [15251877] Int J Dev Neurosci. 2004 Aug-Oct;22(5-6):329-37 [15380832] Brain Res Bull. 1987 May;18(5):601-11 [3607529] Am Rev Respir Dis. 1992 May;145(5):1129-35 [1586058] Am J Respir Crit Care Med. 1995 Sep;152(3):977-83 [7663813] Brain Res Dev Brain Res. 1996 Dec 23;97(2):207-15 [8997505] Eur Respir J. 1997 Aug;10(8):1774-9 [9272918] J Pharmacol Exp Ther. 1998 Jun;285(3):931-45 [9618392] Brain Res Dev Brain Res. 1998 Jun 15;108(1-2):147-60 [9693793] J Clin Invest. 1999 Mar;103(5):637-47 [10074480] Biol Psychiatry. 2005 Jan 1;57(1):56-66 [15607301] Neuropsychopharmacology. 2005 Jan;30(1):129-44 [15316571] Comment In: Am J Prev Med. 2016 Jan;50(1):e27 [26706256] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.amepre.2015.01.015 ER - TY - JOUR T1 - Trends in Disease and Complications of Hepatitis A Virus Infection in the United States, 1999-2011: A New Concern for Adults AN - 1768577893; PQ0002673955 AB - Background. In recent years, few US adults have had exposure and resultant immunity to hepatitis A virus (HAV). Further, persons with liver disease have an increased risk of adverse consequences if they are infected with HAV. Methods. This study used 1999-2011 National Notifiable Diseases Surveillance System and Multiple Cause of Death data to assess trends in the incidence of HAV infection, HAV-related hospitalization, and HAV-related mortality. Results. During 1999-2011, the incidence of HAV infection declined from 6.0 cases/100 000 to 0.4 cases/100 000. Similar declines were seen by sex and age, but persons aged > or =80 years had the highest incidence of HAV infection in 2011 (0.8 cases/100 000). HAV-related hospitalizations increased from 7.3% in 1999 to 24.5% in 2011. The mean age of hospitalized cases increased from 36.0 years in 1999 to 45.1 years in 2011. While HAV-related mortality declined, the mean age at death among decedents with HAV infection increased from 48.0 years in 1999 to 76.2 years in 2011. The median age range of decedents who had HAV infection and a liver-related condition was 51.0 to 68.0 years. Conclusions. Although vaccine-preventable, HAV-related hospitalizations increased greatly, mostly among adults, and liver-related conditions were frequently reported among HAV-infected individuals who died. Public health efforts should focus on the need to assess protection from hepatitis A among adults, including those with liver disease. JF - Journal of Infectious Diseases AU - Ly, Kathleen N AU - Klevens, R Monina AD - Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, kathleenly@cdc.gov Y1 - 2015/07/15/ PY - 2015 DA - 2015 Jul 15 SP - 176 EP - 182 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 212 IS - 2 SN - 0022-1899, 0022-1899 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - hepatitis A virus KW - hepatitis A hospitalizations KW - hepatitis A mortality KW - hepatitis A complications KW - hepatitis A trends KW - Risk assessment KW - Mortality KW - Age KW - Liver diseases KW - Data processing KW - Complications KW - Hepatitis A virus KW - Immunity KW - Infection KW - Public health KW - USA KW - Infectious diseases KW - Liver KW - Hepatitis A KW - Vaccines KW - Hospitals KW - Sex KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768577893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Trends+in+Disease+and+Complications+of+Hepatitis+A+Virus+Infection+in+the+United+States%2C+1999-2011%3A+A+New+Concern+for+Adults&rft.au=Ly%2C+Kathleen+N%3BKlevens%2C+R+Monina&rft.aulast=Ly&rft.aufirst=Kathleen&rft.date=2015-07-15&rft.volume=212&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu834 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Data processing; Liver diseases; Hepatitis A; Immunity; Infection; Sex; Public health; Risk assessment; Infectious diseases; Complications; Liver; Vaccines; Hospitals; Hepatitis A virus; USA DO - http://dx.doi.org/10.1093/infdis/jiu834 ER - TY - JOUR T1 - Validation of Multilevel Regression and Poststratification Methodology for Small Area Estimation of Health Indicators From the Behavioral Risk Factor Surveillance System AN - 1732835040; PQ0001938033 AB - Small area estimation is a statistical technique used to produce reliable estimates for smaller geographic areas than those for which the original surveys were designed. Such small area estimates (SAEs) often lack rigorous external validation. In this study, we validated our multilevel regression and poststratification SAEs from 2011 Behavioral Risk Factor Surveillance System data using direct estimates from 2011 Missouri County-Level Study and American Community Survey data at both the state and county levels. Coefficients for correlation between model-based SAEs and Missouri County-Level Study direct estimates for 115 counties in Missouri were all significantly positive (0.28 for obesity and no health-care coverage, 0.40 for current smoking, 0.51 for diabetes, and 0.69 for chronic obstructive pulmonary disease). Coefficients for correlation between model-based SAEs and American Community Survey direct estimates of no health-care coverage were 0.85 at the county level (811 counties) and 0.95 at the state level. Unweighted and weighted model-based SAEs were compared with direct estimates; unweighted models performed better. External validation results suggest that multilevel regression and poststratification model-based SAEs using single-year Behavioral Risk Factor Surveillance System data are valid and could be used to characterize geographic variations in health indictors at local levels (such as counties) when high-quality local survey data are not available. JF - American Journal of Epidemiology AU - Zhang, Xingyou AU - Holt, James B AU - Yun, Shumei AU - Lu, Hua AU - Greenlund, Kurt J AU - Croft, Janet B AD - Correspondence to Dr. Xingyou Zhang, Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F78, Atlanta, GA 30341, gyx8@cdc.gov PY - 2015 SP - 127 EP - 137 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 182 IS - 2 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - American Community Survey KW - Behavioral Risk Factor Surveillance System KW - external validation KW - Missouri County-Level Study KW - multilevel regression and poststratification KW - small area estimation KW - Diabetes mellitus KW - Obesity KW - Smoking KW - Risk factors KW - USA, Missouri KW - Chronic obstructive pulmonary disease KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732835040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Validation+of+Multilevel+Regression+and+Poststratification+Methodology+for+Small+Area+Estimation+of+Health+Indicators+From+the+Behavioral+Risk+Factor+Surveillance+System&rft.au=Zhang%2C+Xingyou%3BHolt%2C+James+B%3BYun%2C+Shumei%3BLu%2C+Hua%3BGreenlund%2C+Kurt+J%3BCroft%2C+Janet+B&rft.aulast=Zhang&rft.aufirst=Xingyou&rft.date=2015-07-05&rft.volume=182&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwv002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Smoking; Obesity; Risk factors; Chronic obstructive pulmonary disease; USA, Missouri DO - http://dx.doi.org/10.1093/aje/kwv002 ER - TY - JOUR T1 - Association between current asthma and secondhand smoke exposure in vehicles among adults living in four US states AN - 1808637198; PQ0003436060 AB - ObjectiveMany states have implemented laws prohibiting tobacco smoking in indoor public places. However, private settings remain a major source of secondhand smoke (SHS) exposure for many people. We assessed the association between current asthma and SHS exposure in vehicles among adult never-smokers in Indiana, Kentucky, Louisiana and Mississippi.MethodsData came from the 2011 Behavioral Risk Factor Surveillance System, a state-based telephone survey of US adults aged greater than or equal to 18years. Analyses were restricted to states (n=4) that administered an optional SHS module. Prevalence of self-reported asthma and past 7-day SHS exposure in vehicles was calculated by demographics, voluntary smoke-free vehicle rules and SHS exposure in homes, public places and workplaces. Logistic regression was used to assess the adjusted association between asthma and SHS exposure in vehicles.ResultsAmong 17863 never-smoking adults, 7.4% reported having current asthma, whereas 12.3% reported past 7-day SHS exposure in vehicles. Among adults with asthma, SHS exposure in vehicles was lower among those with voluntary smoke-free rules compared with those without voluntary smoke-free rules (9.5% vs 56.7%, p<0.0001). Following adjustment, adults exposed to SHS in a vehicle had a higher odds of having current asthma compared with unexposed adults (OR=2.01, 95% CI 1.18 to 3.40).ConclusionsNever-smoking adults recently exposed to SHS in a vehicle had higher odds of having current asthma compared with unexposed adults. Efforts are warranted to warn about the dangers of SHS and to encourage voluntary smoke-free rules in vehicles, especially among adults with asthma. JF - Tobacco Control AU - Nguyen, Kimberly H AU - King, Brian A AU - Dube, Shanta R AD - Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, , Atlanta, Georgia, USA Y1 - 2015/07/02/ PY - 2015 DA - 2015 Jul 02 SP - 376 EP - 381 PB - BMJ Publishing Group Ltd. VL - 24 IS - 4 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Surveillance and monitoring KW - Secondhand smoke KW - Public policy KW - Smoke KW - Demography KW - Tobacco smoking KW - Risk factors KW - Asthma KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808637198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Association+between+current+asthma+and+secondhand+smoke+exposure+in+vehicles+among+adults+living+in+four+US+states&rft.au=Nguyen%2C+Kimberly+H%3BKing%2C+Brian+A%3BDube%2C+Shanta+R&rft.aulast=Nguyen&rft.aufirst=Kimberly&rft.date=2015-07-02&rft.volume=24&rft.issue=4&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2013-051526 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Demography; Smoke; Tobacco smoking; Risk factors; Asthma DO - http://dx.doi.org/10.1136/tobaccocontrol-2013-051526 ER - TY - JOUR T1 - A Recently Discovered Pathogenic Paramyxovirus, Sosuga Virus, is Present in Rousettus aegyptiacus Fruit Bats at Multiple Locations in Uganda AN - 1837336402; PQ0003751839 AB - In August 2012, a wildlife biologist became ill immediately following a 6-wk field trip to collect bats and rodents in South Sudan and Uganda. After returning to the US, the biologist was admitted to the hospital with multiple symptoms including fever, malaise, headache, generalized myalgia and arthralgia, stiffness in the neck, and sore throat. Soon after admission, the patient developed a maculopapular rash and oropharynx ulcerations. The patient remained hospitalized for 14 d. Several suspect pathogens, including viral hemorrhagic fever viruses such as Ebola viruses and Marburg viruses, were ruled out through standard diagnostic testing. However, deep sequencing and metagenomic analyses identified a novel paramyxovirus, later named Sosuga virus, in the patient's blood. To determine the potential source, bat tissues collected during the 3-wk period just prior to the onset of symptoms were tested for Sosuga virus, and several Egyptian rousette bats (Rousettus aegyptiacus) were found to be positive. Further analysis of archived Egyptian rousette tissues collected at other localities in Uganda found additional Sosuga virus-positive bats, suggesting this species could be a potential natural reservoir for this novel paramyxovirus. JF - Journal of Wildlife Diseases AU - Amman, Brian R AU - Albarino, Cesar G AU - Bird, Brian H AU - Nyakarahuka, Luke AU - Sealy, Tara K AU - Balinandi, Stephen AU - Schuh, Amy J AU - Campbell, Shelly M AU - Stroher, Ute AU - Jones, Megan E B AD - Centers for Disease Control and Prevention, Viral Special Pathogens Branch, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 774 EP - 779 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 United States VL - 51 IS - 3 SN - 0090-3558, 0090-3558 KW - Virology & AIDS Abstracts; Ecology Abstracts KW - Bats KW - paramyxovirus KW - Rousettus aegyptiacus KW - Sosuga virus KW - spillover KW - wildlife biologist KW - Fruits KW - Oropharynx KW - Ebolavirus KW - Wildlife KW - Paramyxovirus KW - Pharyngitis KW - Pathogens KW - Neck KW - Fever KW - Blood KW - Exanthema KW - Headache KW - Hemorrhagic fever KW - Marburgvirus KW - Arthralgia KW - Myalgia KW - Hospitals KW - D 04040:Ecosystem and Ecology Studies KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837336402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Diseases&rft.atitle=A+Recently+Discovered+Pathogenic+Paramyxovirus%2C+Sosuga+Virus%2C+is+Present+in+Rousettus+aegyptiacus+Fruit+Bats+at+Multiple+Locations+in+Uganda&rft.au=Amman%2C+Brian+R%3BAlbarino%2C+Cesar+G%3BBird%2C+Brian+H%3BNyakarahuka%2C+Luke%3BSealy%2C+Tara+K%3BBalinandi%2C+Stephen%3BSchuh%2C+Amy+J%3BCampbell%2C+Shelly+M%3BStroher%2C+Ute%3BJones%2C+Megan+E+B&rft.aulast=Amman&rft.aufirst=Brian&rft.date=2015-07-01&rft.volume=51&rft.issue=3&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Diseases&rft.issn=00903558&rft_id=info:doi/10.7589%2F2015-02-044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Fruits; Oropharynx; Wildlife; Pathogens; Pharyngitis; Neck; Fever; Exanthema; Blood; Headache; Hemorrhagic fever; Myalgia; Arthralgia; Hospitals; Ebolavirus; Paramyxovirus; Marburgvirus DO - http://dx.doi.org/10.7589/2015-02-044 ER - TY - JOUR T1 - Collection and Utilization of Animal Carcasses Associated with zoonotic Disease in Tshuapa District, the Democratic Republic of the Congo, 2012 AN - 1837329272; PQ0003751831 AB - The collection and consumption of animal carcasses is a common activity in forested areas of the Congo River basin and creates sustainability, conservation, and health concerns. Residents of the Tshuapa District reported collecting the remains of 5,878 animals from >30 species when surveyed about their wildlife consumption habits. Carcasses were discovered in varying degrees of decomposition and were often consumed at home or sold in local markets. The most commonly collected animals were Cricetomys gambianus(Northern giant pouched rat), Cercopithecus ascanius(red-tailed monkey), and Heliosciurus rufobrachium(red-legged sun squirrel). Many of the species recorded may be hosts of zoonotic pathogens, creating concern for spillover events. JF - Journal of Wildlife Diseases AU - Monroe, Benjamin P AU - Doty, Jeffrey B AU - Moses, Cynthia AU - Ibata, Saturnin AU - Reynolds, Mary AU - Carroll, Darin AD - Poxvirus and Rabies Program, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Mailstop A-30, 1600 Clifton Road, Atlanta Georgia, USA, BMonroe@cdc.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 734 EP - 738 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 United States VL - 51 IS - 3 SN - 0090-3558, 0090-3558 KW - Ecology Abstracts KW - Bushmeat KW - carcass KW - Ebola KW - monkeypox KW - primate KW - rodent KW - spillover KW - Carcasses KW - Sun KW - Wildlife KW - Cercopithecus KW - Conservation KW - River basins KW - Pathogens KW - Decomposition KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837329272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Diseases&rft.atitle=Collection+and+Utilization+of+Animal+Carcasses+Associated+with+zoonotic+Disease+in+Tshuapa+District%2C+the+Democratic+Republic+of+the+Congo%2C+2012&rft.au=Monroe%2C+Benjamin+P%3BDoty%2C+Jeffrey+B%3BMoses%2C+Cynthia%3BIbata%2C+Saturnin%3BReynolds%2C+Mary%3BCarroll%2C+Darin&rft.aulast=Monroe&rft.aufirst=Benjamin&rft.date=2015-07-01&rft.volume=51&rft.issue=3&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Diseases&rft.issn=00903558&rft_id=info:doi/10.7589%2F2014-05-140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Carcasses; Wildlife; Sun; Conservation; River basins; Pathogens; Decomposition; Cercopithecus DO - http://dx.doi.org/10.7589/2014-05-140 ER - TY - JOUR T1 - Body mass index, respiratory conditions, asthma, and chronic obstructive pulmonary disease AN - 1827917951; PQ0001902535 AB - Background This study aims to assess the relationship of body mass index (BMI) status with respiratory conditions, asthma, and chronic obstructive pulmonary disease (COPD) in a state population. Methods Self-reported data from 11,868 adults aged greater than or equal to 18 years in the 2012 South Carolina Behavioral Risk Factor Surveillance System telephone survey were analyzed using multivariable logistic regression that accounted for the complex sampling design and adjusted for sex, age, race/ethnicity, education, smoking status, physical inactivity, and cancer history. Results The distribution of BMI (kg/m2) was 1.5% for underweight (<18.5), 32.3% for normal weight (18.5-24.9), 34.6% for overweight (25.0-29.9), 26.5% for obese (30.0-39.9), and 5.1% for morbidly obese ( greater than or equal to 40.0). Among respondents, 10.0% had frequent productive cough, 4.3% had frequent shortness of breath (SOB), 7.3% strongly agreed that SOB affected physical activity, 8.4% had current asthma, and 7.4% had COPD. Adults at extremes of body weight were more likely to report having asthma or COPD, and to report respiratory conditions. Age-adjusted U-shaped relationships of BMI categories with current asthma and strongly agreeing that SOB affected physical activity, but not U-shaped relationship with COPD, persisted after controlling for the covariates (p < 0.001). Morbidly obese but not underweight or obese respondents were significantly more likely to have frequent productive cough and frequent SOB than normal weight adults after adjustment. Conclusion Our data confirm that both underweight and obesity are associated with current asthma and obesity with COPD. Increased emphasis on exercise and nutrition may improve respiratory conditions. JF - Respiratory Medicine AU - Liu, Yong AU - Pleasants, Roy A AU - Croft, Janet B AU - Lugogo, Njira AU - Ohar, Jill AU - Heidari, Khosrow AU - Strange, Charlie AU - Wheaton, Anne G AU - Mannino, David M AU - Kraft, Monica AD - Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 851 EP - 859 PB - Elsevier B.V., Radarweg 29 Amsterdam 1043 NX Netherlands VL - 109 IS - 7 SN - 0954-6111, 0954-6111 KW - Toxicology Abstracts KW - Body mass index KW - Chronic obstructive pulmonary disease KW - Asthma KW - Respiratory conditions KW - Population-based study KW - COPD chronic obstructive pulmonary disease KW - BRFSS Behavioral Risk Factor Surveillance System KW - SOB shortness of breath KW - BMI body mass index KW - Obesity KW - Data processing KW - Physical activity KW - Cough KW - Underweight KW - Nutrition KW - Cancer KW - Physical training KW - Smoking KW - Body weight KW - Risk factors KW - Sampling KW - Ethnic groups KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827917951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Respiratory+Medicine&rft.atitle=Body+mass+index%2C+respiratory+conditions%2C+asthma%2C+and+chronic+obstructive+pulmonary+disease&rft.au=Liu%2C+Yong%3BPleasants%2C+Roy+A%3BCroft%2C+Janet+B%3BLugogo%2C+Njira%3BOhar%2C+Jill%3BHeidari%2C+Khosrow%3BStrange%2C+Charlie%3BWheaton%2C+Anne+G%3BMannino%2C+David+M%3BKraft%2C+Monica&rft.aulast=Liu&rft.aufirst=Yong&rft.date=2015-07-01&rft.volume=109&rft.issue=7&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Respiratory+Medicine&rft.issn=09546111&rft_id=info:doi/10.1016%2Fj.rmed.2015.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 49 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Data processing; Physical activity; Asthma; Cough; Underweight; Nutrition; Cancer; Physical training; Chronic obstructive pulmonary disease; Smoking; Body weight; Risk factors; Sampling; Body mass index; Ethnic groups DO - http://dx.doi.org/10.1016/j.rmed.2015.05.006 ER - TY - JOUR T1 - Rotavirus Group A Genotypes Detected Through Diarrheal Disease Surveillance in Haiti, 2012 AN - 1722168468; PQ0002060601 AB - Samples collected in 2012 through diarrheal disease surveillance in Haiti were tested for rotavirus by enzyme immunoassay and real time RT-PCR and positive samples were genotyped. The predominant genotypes were G1P[8] (29% prevalence) and G9P[8] (21%). The observed genotype prevalence was similar to that reported previously for other Caribbean countries. JF - American Journal of Tropical Medicine and Hygiene AU - Esona, Mathew D AU - Buteau, Josiane AU - Lucien, Mentor Ali Ber AU - Joseph, Gerard A AU - Leshem, Eyal AU - Boncy, Jacques AU - Katz, Mark A AU - Bowen, Michael D AU - Balajee, S Arunmozhi AD - Centers for Disease Control and Prevention, Atlanta, Georgia, mkb6@cdc.gov Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 54 EP - 56 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 93 IS - 1 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Rotavirus KW - Diarrhea KW - Surveillance and enforcement KW - Genotypes KW - Enzyme immunoassay KW - Polymerase chain reaction KW - Disease detection KW - Hygiene KW - Immunoassays KW - ASW, Caribbean Sea, Greater Antilles, Haiti KW - K 03330:Biochemistry KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22310:Genetics, Taxonomy & Structure KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Rotavirus+Group+A+Genotypes+Detected+Through+Diarrheal+Disease+Surveillance+in+Haiti%2C+2012&rft.au=Esona%2C+Mathew+D%3BButeau%2C+Josiane%3BLucien%2C+Mentor+Ali+Ber%3BJoseph%2C+Gerard+A%3BLeshem%2C+Eyal%3BBoncy%2C+Jacques%3BKatz%2C+Mark+A%3BBowen%2C+Michael+D%3BBalajee%2C+S+Arunmozhi&rft.aulast=Esona&rft.aufirst=Mathew&rft.date=2015-07-01&rft.volume=93&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0403 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Surveillance and enforcement; Polymerase chain reaction; Disease detection; Genotypes; Hygiene; Immunoassays; Diarrhea; Enzyme immunoassay; Rotavirus; ASW, Caribbean Sea, Greater Antilles, Haiti DO - http://dx.doi.org/10.4269/ajtmh.14-0403 ER - TY - JOUR T1 - Social support and condom use among female sex workers in China AN - 1704341620; 4694346 AB - While the relationship between social support and psychological well-being has been well established, limited studies have explored how social support might affect condom use among female sex workers (FSWs). Using cross-sectional data from 1,022 FSWs in Guangxi, China, we examined how different forms of support from diverse sources may influence condom use among FSWs. Friends, coworkers, and stable partners were FSWs' main sources of social support. Social support from diverse sources differently impacts FSWs' condom use. Policymakers need to consider the complicated profile of social support received by FSWs and create supportive environment for FSWs to protect themselves from HIV risks. Reprinted by permission of Taylor & Francis Ltd. JF - Health care for women international AU - Qiao, Shan AU - Li, Xiaoming AU - Zhang, Chen AU - Zhou, Yuejiao AU - Shen, Zhiyong AU - Tang, Zhenzhu AD - Wayne State University ; Vanderbilt University ; Guangxi Center for Disease Control and Prevention Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 834 EP - 850 VL - 36 IS - 7 SN - 0739-9332, 0739-9332 KW - Sociology KW - Condoms KW - Sex workers KW - Social support KW - Well-being KW - Policy making KW - HIV KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704341620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+for+women+international&rft.atitle=Social+support+and+condom+use+among+female+sex+workers+in+China&rft.au=Qiao%2C+Shan%3BLi%2C+Xiaoming%3BZhang%2C+Chen%3BZhou%2C+Yuejiao%3BShen%2C+Zhiyong%3BTang%2C+Zhenzhu&rft.aulast=Qiao&rft.aufirst=Shan&rft.date=2015-07-01&rft.volume=36&rft.issue=7&rft.spage=834&rft.isbn=&rft.btitle=&rft.title=Health+care+for+women+international&rft.issn=07399332&rft_id=info:doi/10.1080%2F07399332.2014.971952 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 11938 11949 13521; 5703 3617 6220; Condoms; 11556 13682; 13530 13521; 9625 9628; 93 116 30 DO - http://dx.doi.org/10.1080/07399332.2014.971952 ER - TY - JOUR T1 - Violence against Chinese female sex workers from their stable partners: a hierarchical multiple regression analysis AN - 1704341473; 4694344 AB - Limited data are available regarding risk factors that are related to intimate partner violence (IPV) against female sex workers (FSWs) in the context of stable partnerships. Out of the 1,022 FSWs, 743 reported ever having a stable partnership and 430 (more than half) of those reported experiencing IPV. Hierarchical multivariate regression revealed that some characteristics of stable partners (e.g., low education, alcohol use) and relationship stressors (e.g., frequent friction, concurrent partnerships) were independently predictive of IPV against FSWs. Public health professionals who design future violence prevention interventions targeting FSWs need to consider the influence of their stable partners. Reprinted by permission of Taylor & Francis Ltd. JF - Health care for women international AU - Zhang, Chen AU - Li, Xiaoming AU - Su, Shaobing AU - Hong, Yan AU - Zhou, Yuejiao AU - Tang, Zhenzhu AU - Shen, Zhiyong AD - Vanderbilt University ; Wayne State University ; Texas A&M University ; Guangxi Center for Disease Control and Prevention Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 797 EP - 815 VL - 36 IS - 7 SN - 0739-9332, 0739-9332 KW - Sociology KW - Sex workers KW - Health care KW - Mental stress KW - Domestic violence KW - China KW - Medical personnel KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704341473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+for+women+international&rft.atitle=Violence+against+Chinese+female+sex+workers+from+their+stable+partners%3A+a+hierarchical+multiple+regression+analysis&rft.au=Zhang%2C+Chen%3BLi%2C+Xiaoming%3BSu%2C+Shaobing%3BHong%2C+Yan%3BZhou%2C+Yuejiao%3BTang%2C+Zhenzhu%3BShen%2C+Zhiyong&rft.aulast=Zhang&rft.aufirst=Chen&rft.date=2015-07-01&rft.volume=36&rft.issue=7&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Health+care+for+women+international&rft.issn=07399332&rft_id=info:doi/10.1080%2F07399332.2014.909432 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 11556 13682; 3708 13325; 10449 5772; 7884 13682; 5775 13521; 7953 7954; 93 116 30 DO - http://dx.doi.org/10.1080/07399332.2014.909432 ER - TY - JOUR T1 - Predictors of consistent condom use among Chinese female Sex workers: an application of the protection motivation theory AN - 1704339771; 4694345 AB - We utilized Protection Motivation Theory to assess predictors of intention and behavior of consistent condom use among Chinese female sex workers (FSWs). A self-administered questionnaire was used in a cross-sectional survey among 700 FSWs in Guangxi, China. Multivariate logistic regression analysis indicated that extrinsic and intrinsic rewards, self-efficacy, and response costs predicted consistent condom use intention and behavior among FSWs. Sexually transmitted infection/ HIV prevention programs need to reduce FSWs' perceptions of positive extrinsic rewards and intrinsic rewards for engaging in consistent condom use, reduce FSWs' perception of response costs for using a condom, and increase condom use self-efficacy among FSWs. Reprinted by permission of Taylor & Francis Ltd. JF - Health care for women international AU - Zhang, Liying AU - Li, Xiaoming AU - Zhou, Yuejiao AU - Lin, Danhua AU - Su, Shaobing AU - Zhang, Chen AU - Stanton, Bonita AD - Wayne State University ; Guangxi Center for Disease Control and Prevention ; Beijing Normal University ; Vanderbilt University Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 816 EP - 833 VL - 36 IS - 7 SN - 0739-9332, 0739-9332 KW - Sociology KW - Sexuality KW - Condoms KW - Sex workers KW - Regression analysis KW - Females KW - HIV KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704339771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+for+women+international&rft.atitle=Predictors+of+consistent+condom+use+among+Chinese+female+Sex+workers%3A+an+application+of+the+protection+motivation+theory&rft.au=Zhang%2C+Liying%3BLi%2C+Xiaoming%3BZhou%2C+Yuejiao%3BLin%2C+Danhua%3BSu%2C+Shaobing%3BZhang%2C+Chen%3BStanton%2C+Bonita&rft.aulast=Zhang&rft.aufirst=Liying&rft.date=2015-07-01&rft.volume=36&rft.issue=7&rft.spage=816&rft.isbn=&rft.btitle=&rft.title=Health+care+for+women+international&rft.issn=07399332&rft_id=info:doi/10.1080%2F07399332.2014.942902 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - Condoms; 11556 13682; 4865 11538; 5703 3617 6220; 10739 12228 10919; 11579 11538; 93 116 30 DO - http://dx.doi.org/10.1080/07399332.2014.942902 ER - TY - JOUR T1 - Psychological stressors in the context of commercial sex among female sex workers in China AN - 1704339750; 4694342 AB - Because of the illegality and stigma associated with female sex workers (FSWs) in China, data were limited regarding their psychological stressors examined through the lens of occupational health. Analyzing qualitative data from 16 gatekeepers and 38 FSWs, we explored these stressors in the context of commercial sex in China. We found that FSWs faced a continuum of stressors that resulted from poverty, limited employment, lack of social protection, violence perpetrated by clients, and limited social support from peers and stable partners. We call for empowerment and a structural approach to address the needs of FSWs to improve their psychological well-being. Reprinted by permission of Taylor & Francis Ltd. JF - Health care for women international AU - Zhang, Chen AU - Hong, Yan AU - Li, Xiaoming AU - Qiao, Shan AU - Zhou, Yuejiao AU - Su, Shaobing AD - Vanderbilt University ; Texas A&M University ; Wayne State University ; Guangxi Center for Disease Control and Prevention Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 753 EP - 767 VL - 36 IS - 7 SN - 0739-9332, 0739-9332 KW - Sociology KW - Sex workers KW - Social support KW - Poverty KW - Feminism KW - Commercial workers KW - Violence KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704339750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+for+women+international&rft.atitle=Psychological+stressors+in+the+context+of+commercial+sex+among+female+sex+workers+in+China&rft.au=Zhang%2C+Chen%3BHong%2C+Yan%3BLi%2C+Xiaoming%3BQiao%2C+Shan%3BZhou%2C+Yuejiao%3BSu%2C+Shaobing&rft.aulast=Zhang&rft.aufirst=Chen&rft.date=2015-07-01&rft.volume=36&rft.issue=7&rft.spage=753&rft.isbn=&rft.btitle=&rft.title=Health+care+for+women+international&rft.issn=07399332&rft_id=info:doi/10.1080%2F07399332.2013.838247 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 11556 13682; 2540 13682; 11938 11949 13521; 4867 6203; 9962; 13325; 93 116 30 DO - http://dx.doi.org/10.1080/07399332.2013.838247 ER - TY - JOUR T1 - Primary Care Providersʼ Recommendations for Hypertension Prevention, DocStyles Survey, 2012 AN - 1701262442 AB - Healthy behaviors, including maintaining an ideal body weight, eating a healthy diet, being physically active, limiting alcohol intake, and not smoking, can help prevent hypertension. The objective of this study was to determine the prevalence of recommending these behaviors to patients by primary care providers (PCPs) and to assess what PCP characteristics, if any, were associated with making the recommendations. DocStyles 2012, a Web based panel survey, was used to assess PCPsʼ demographic characteristics, health-related behaviors, practice setting, and prevalence of making selected recommendations to prevent hypertension. Logistic regression was used to calculate the odds of making all 6 recommendations, by demographic, professional, or personal health behavior characteristics. Most PCPs recommended healthy behaviors to their adult patients to prevent hypertension. PCPsʼ own healthy behaviors were associated with their recommendations. Preventing hypertension is a multifactorial effort, and in the clinical environment, PCPs have frequent opportunities to model and promote healthy lifestyles to their patients. JF - Journal of Primary Care & Community Health AU - Ayala, Carma AU - Loustalot, Fleetwood AD - National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Fang, Jing; National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 170 EP - 176 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 6 IS - 3 SN - 2150-1319 KW - Medical Sciences KW - primary care providers KW - hypertension (high blood pressure) KW - prevention KW - healthy behaviors KW - Blood pressure KW - Healthy habits KW - Hypertension KW - Patient care KW - Primary health care KW - Smoking KW - Body weight KW - Characteristics KW - Clinical guidelines KW - Demographic aspects KW - Diet KW - Eating KW - Health behaviour KW - Health professionals KW - Healthy food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701262442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Care+%26+Community+Health&rft.atitle=Primary+Care+Providers%CA%BC+Recommendations+for+Hypertension+Prevention%2C+DocStyles+Survey%2C+2012&rft.au=Fang%2C+Jing%3BAyala%2C+Carma%3BLoustalot%2C+Fleetwood&rft.aulast=Fang&rft.aufirst=Jing&rft.date=2015-07-01&rft.volume=6&rft.issue=3&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Care+%26+Community+Health&rft.issn=21501319&rft_id=info:doi/10.1177%2F2150131915568997 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1177/2150131915568997 ER - TY - JOUR T1 - What we don't know can hurt us: Nonresponse bias assessment in birth defects research. AN - 1698034261; 26173046 AB - Nonresponse bias assessment is an important and underutilized tool in survey research to assess potential bias due to incomplete participation. This study illustrates a nonresponse bias sensitivity assessment using a survey on perceived barriers to care for children with orofacial clefts in North Carolina. Children born in North Carolina between 2001 and 2004 with an orofacial cleft were eligible for inclusion. Vital statistics data, including maternal and child characteristics, were available on all eligible subjects. Missing 'responses' from nonparticipants were imputed using assumptions based on the distribution of responses, survey method (mail or phone), and participant maternal demographics. Overall, 245 of 475 subjects (51.6%) responded to either a mail or phone survey. Cost as a barrier to care was reported by 25.0% of participants. When stratified by survey type, 28.3% of mail respondents and 17.2% of phone respondents reported cost as a barrier. Under various assumptions, the bias-adjusted estimated prevalence of cost as barrier to care ranged from 16.1% to 30.0%. Maternal age, education, race, and marital status at time of birth were not associated with subjects reporting cost as a barrier. As survey response rates continue to decline, the importance of assessing the potential impact of nonresponse bias has become more critical. Birth defects research is particularly conducive to nonresponse bias analysis, especially when birth defect registries and birth certificate records are used. Future birth defect studies which use population-based surveillance data and have incomplete participation could benefit from this type of nonresponse bias assessment. Birth Defects Research (Part A) 103:603-609, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Strassle, Paula D AU - Cassell, Cynthia H AU - Shapira, Stuart K AU - Tinker, Sarah C AU - Meyer, Robert E AU - Grosse, Scott D AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. ; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia. ; North Carolina Birth Defects Monitoring Program, State Center for Health Statistics, North Carolina Division of Public Health, Raleigh, North Carolina. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 603 EP - 609 VL - 103 IS - 7 KW - Index Medicus KW - nonresponse bias KW - response rates KW - barriers to care KW - orofacial clefts KW - Humans KW - North Carolina KW - Cleft Palate KW - Cleft Lip KW - Bias (Epidemiology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698034261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=What+we+don%27t+know+can+hurt+us%3A+Nonresponse+bias+assessment+in+birth+defects+research.&rft.au=Strassle%2C+Paula+D%3BCassell%2C+Cynthia+H%3BShapira%2C+Stuart+K%3BTinker%2C+Sarah+C%3BMeyer%2C+Robert+E%3BGrosse%2C+Scott+D&rft.aulast=Strassle&rft.aufirst=Paula&rft.date=2015-07-01&rft.volume=103&rft.issue=7&rft.spage=603&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23408 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-15 N1 - Date created - 2015-07-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Med Care. 2002 Mar;40(3):190-200 [11880792] Epidemiology. 2009 Nov;20(6):872-9 [19704374] JAMA. 2012 May 2;307(17):1805-6 [22550194] Cleft Palate Craniofac J. 2012 May;49(3):262-9 [21740175] Health Serv Res. 2013 Jun;48(3):913-30 [23046097] Health Serv Res. 2013 Jun;48(3):905-12 [23656501] Birth Defects Res A Clin Mol Teratol. 2013 Oct;97(10):685-95 [24039055] Birth Defects Res A Clin Mol Teratol. 2014 Nov;100(11):837-47 [25200965] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23408 ER - TY - JOUR T1 - Factors associated with inpatient hospitalizations among patients aged 1 to 64 years with congenital heart defects, Arkansas 2006 to 2011. AN - 1698030957; 26172576 AB - Individuals with congenital heart defects (CHDs) have high hospital resource use. We sought to identify factors associated with hospital costs and multiple hospitalizations among individuals with CHDs. Data from the 2006 to 2011 Healthcare Cost and Utilization Project Arkansas State Inpatient Databases were linked across encrypted patient identifiers to develop a cohort of Arkansas residents aged 1 to 64 years who were hospitalized at least once with a CHD during this time period. Infants were excluded because patient identifiers were missing for 18 to 52% each year. CHDs were identified using principal and secondary International Classification of Diseases, Ninth Revision, Clinical Modification diagnoses codes. All hospitalizations of individuals ever admitted with a CHD were included. Mean and median patient-level costs were estimated; the association of hospital costs and patient readmissions were examined with linear and logistic regression. There were 1,185,868 inpatient hospitalizations of Arkansas residents aged 1 to 64 years between 2006 and 2011; these were accrued by 603,925 patients. Of those, 2542 patients (0.42%) had at least one hospitalization with a CHD diagnosis. Total costs for these 2542 patients were $126,999,837 and they accumulated 7898 hospitalizations. Factors associated with increased costs included patient age, CHD type, cardiac procedures, and comorbidities. Factors associated with hospital readmission within 1 year included age, CHD type, expected payer, and comorbidities. Individuals with CHDs in Arkansas experience variation in hospital use and costs by patient characteristics. Future research should investigate factors associated with readmissions, cardiac procedures, and comorbidities, as these are strongly associated with hospital costs. Birth Defects Research (Part A) 103:589-596, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Simeone, Regina M AU - Oster, Matthew E AU - Hobbs, Charlotte A AU - Robbins, James M AU - Thomas Collins, R AU - Honein, Margaret A AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 589 EP - 596 VL - 103 IS - 7 KW - Index Medicus KW - Healthcare Cost and Utilization Project KW - One-year readmission KW - Congenital heart defects KW - Person-level KW - Arkansas KW - hospital costs KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Middle Aged KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Hospitalization KW - Heart Defects, Congenital -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698030957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Factors+associated+with+inpatient+hospitalizations+among+patients+aged+1+to+64+years+with+congenital+heart+defects%2C+Arkansas+2006+to+2011.&rft.au=Simeone%2C+Regina+M%3BOster%2C+Matthew+E%3BHobbs%2C+Charlotte+A%3BRobbins%2C+James+M%3BThomas+Collins%2C+R%3BHonein%2C+Margaret+A&rft.aulast=Simeone&rft.aufirst=Regina&rft.date=2015-07-01&rft.volume=103&rft.issue=7&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23402 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-15 N1 - Date created - 2015-07-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2009 Jul 28;54(5):460-7 [19628123] Pediatrics. 1998 Jul;102(1 Pt 1):35-43 [9651411] Circ Cardiovasc Qual Outcomes. 2011 May;4(3):306-12 [21505154] Pediatrics. 2011 Jun;127(6):e1482-9 [21576309] Pediatrics. 2011 Nov;128(5):e1259-67 [21987707] Vital Health Stat 2. 2012 Jan;(154):1-65 [22783637] Birth Defects Res A Clin Mol Teratol. 2013 Feb;97(2):87-94 [23404870] Pediatrics. 2013 May;131(5):e1502-8 [23610203] Pediatrics. 2014 Mar;133(3):e553-60 [24567024] Circulation. 2014 Aug 26;130(9):749-56 [24944314] Birth Defects Res A Clin Mol Teratol. 2014 Dec;100(12):934-43 [24975483] J Am Coll Cardiol. 2001 Apr;37(5):1170-5 [11300418] Med Care. 1998 Jan;36(1):8-27 [9431328] Birth Defects Res A Clin Mol Teratol. 2015 Sep;103(9):814-20 [26069215] Pediatrics. 2005 Sep;116(3):689-95 [16140709] J Perinatol. 2005 Nov;25(11):737-42 [16163368] Circulation. 2007 Jan 16;115(2):163-72 [17210844] Am J Cardiol. 2007 Mar 15;99(6):839-43 [17350378] Congenit Heart Dis. 2007 Sep-Oct;2(5):319-26 [18377447] J Pediatr. 2008 Dec;153(6):807-13 [18657826] Cardiol Young. 2008 Dec;18 Suppl 2:92-100 [19063779] Acta Paediatr. 2009 Mar;98(3):472-7 [19046347] Circulation. 2009 Aug 4;120(5):447-58 [19581492] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23402 ER - TY - JOUR T1 - Immunity to polio, measles and rubella in women of child-bearing age and estimated congenital rubella syndrome incidence, Cambodia, 2012 AN - 1694984149; PQ0001623352 AB - Significant gaps in immunity to polio, measles, and rubella may exist in adults in Cambodia and threaten vaccine-preventable disease (VPD) elimination and control goals, despite high childhood vaccination coverage. We conducted a nationwide serological survey during November-December 2012 of 2154 women aged 15-39 years to assess immunity to polio, measles, and rubella and to estimate congenital rubella syndrome (CRS) incidence. Measles and rubella antibodies were detected by IgG ELISA and polio antibodies by microneutralization testing. Age-structured catalytic models were fitted to rubella serological data to predict CRS cases. Overall, 29.8% of women lacked immunity to at least one poliovirus (PV); seroprevalence to PV1, PV2 and PV3 was 85.9%, 93.4% and 83.3%, respectively. Rubella and measles antibody seroprevalence was 73.3% and 95.9%, respectively. In the 15-19 years age group, 48.2% [95% confidence interval (CI) 42.4-54.1] were susceptible to either PV1 or PV3, and 40.3% (95% CI 33.0-47.5) to rubella virus. Based on rubella antibody seroprevalence, we estimate that >600 infants are born with CRS in Cambodia annually. Significant numbers of Cambodian women are still susceptible to polio and rubella, especially those aged 15-19 years, emphasizing the need to include adults in VPD surveillance and a potential role for vaccination strategies targeted at adults. JF - Epidemiology and Infection AU - Mao, B AU - CHHENG, K AU - Wannemuehler, K AU - VYNNYCKY, E AU - Buth, S AU - SOEUNG, S C AU - Reef, S AU - Weldon, W AU - Quick, L AU - Gregory, C J AD - University of Health Sciences, Phnom Penh, Cambodia, hgk4@cdc.gov PY - 2015 SP - 1858 EP - 1867 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 9 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Poliovirus KW - Enzyme-linked immunosorbent assay KW - Age KW - Data processing KW - Measles KW - Immunity KW - Children KW - Vaccination KW - Rubella KW - Models KW - Rubella virus KW - Serological surveys KW - Cambodia KW - Congenital rubella KW - Immunoglobulin G KW - Age groups KW - Vaccines KW - Females KW - Infants KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694984149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Immunity+to+polio%2C+measles+and+rubella+in+women+of+child-bearing+age+and+estimated+congenital+rubella+syndrome+incidence%2C+Cambodia%2C+2012&rft.au=Mao%2C+B%3BCHHENG%2C+K%3BWannemuehler%2C+K%3BVYNNYCKY%2C+E%3BButh%2C+S%3BSOEUNG%2C+S+C%3BReef%2C+S%3BWeldon%2C+W%3BQuick%2C+L%3BGregory%2C+C+J&rft.aulast=Mao&rft.aufirst=B&rft.date=2015-07-01&rft.volume=143&rft.issue=9&rft.spage=1858&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268814002817 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Number of references - 32 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Age; Enzyme-linked immunosorbent assay; Data processing; Measles; Immunity; Children; Rubella; Vaccination; Models; Serological surveys; Congenital rubella; Immunoglobulin G; Infants; Poliovirus; Age groups; Females; Vaccines; Rubella virus; Cambodia DO - http://dx.doi.org/10.1017/S0950268814002817 ER - TY - JOUR T1 - Trends and characteristics of heroin overdoses in Wisconsin, 2003-2012. AN - 1686414308; 25935735 AB - Heroin abuse has increased substantially during the past decade in the United States. This study describes trends and demographic shifts of heroin overdoses and heroin-related fatalities in Wisconsin and contrasts these with prescription opioid overdoses. This study was cross-sectional using databases of emergency department (ED) visits, hospital admissions, and death certificates in Wisconsin, United States, during 2003-2012. Cases were Wisconsin residents treated for heroin or prescription opioid overdose, and residents who died of heroin-related drug poisoning. Primary measurements were rates over time and by geographic region, and rates and rate ratios for selected demographic characteristics. During 2003-2012, age-adjusted rates of heroin overdoses treated in EDs increased from 1.0 to 7.9/100,000 persons; hospitalized heroin overdoses increased from 0.7 to 3.5/100,000. Whites accounted for 68% of hospitalized heroin overdoses during 2003-2007 but 80% during 2008-2012. Heroin-related deaths were predominantly among urban residents; however, rural fatalities accounted for zero deaths in 2003 but 31 (17%) deaths in 2012. Among patients aged 18-34 years, those hospitalized with heroin overdose were more often men (73.0% versus 54.9%), uninsured (44.2% versus 29.9%), and urban (84.3% versus 73.2%) than those with prescription opioid overdose. Rates of ED visits for heroin overdose in this age group exceeded rates for prescription opioid overdose in 2012 (26.1/100,000 versus 12.6/100,000 persons, respectively). An epidemic of heroin abuse is characterized by demographic shifts toward whites and rural residents. Rates of heroin overdose in younger persons now exceed rates of prescription opioid overdose. Published by Elsevier Ireland Ltd. JF - Drug and alcohol dependence AU - Meiman, Jon AU - Tomasallo, Carrie AU - Paulozzi, Leonard AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Wisconsin Division of Public Health, 1 West Wilson Street, Room 150, Madison, WI 53703, United States. Electronic address: xdf5@cdc.gov. ; Wisconsin Division of Public Health, 1 West Wilson Street, Room 150, Madison, WI 53703, United States. Electronic address: Carrie.Tomasallo@dhs.wisconsin.gov. ; National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, CDC El Paso Quarantine Station, 601 Sunland Park Drive, Suite 200, El Paso, TX 79912, United States. Electronic address: LBP4@cdc.gov. Y1 - 2015/07/01/ PY - 2015 DA - 2015 Jul 01 SP - 177 EP - 184 VL - 152 KW - Analgesics, Opioid KW - 0 KW - Heroin KW - 70D95007SX KW - Index Medicus KW - Mortality KW - Prescription opioids KW - Overdose KW - Wisconsin KW - Young Adult KW - Age Factors KW - Urban Population -- statistics & numerical data KW - Sex Factors KW - Humans KW - Rural Population -- statistics & numerical data KW - Aged KW - Cross-Sectional Studies KW - Heroin Dependence -- epidemiology KW - Wisconsin -- epidemiology KW - Adult KW - Emergency Service, Hospital -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Analgesics, Opioid -- poisoning KW - Drug Overdose -- mortality KW - Heroin -- poisoning KW - Drug Overdose -- epidemiology KW - Hospitalization -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686414308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Trends+and+characteristics+of+heroin+overdoses+in+Wisconsin%2C+2003-2012.&rft.au=Meiman%2C+Jon%3BTomasallo%2C+Carrie%3BPaulozzi%2C+Leonard&rft.aulast=Meiman&rft.aufirst=Jon&rft.date=2015-07-01&rft.volume=152&rft.issue=8&rft.spage=623&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2011.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-08 N1 - Date created - 2015-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.drugalcdep.2015.04.002 ER - TY - JOUR T1 - Using Behavioral Risk Factor Surveillance System Data to Estimate the Percentage of the Population Meeting US Department of Agriculture Food Patterns Fruit and Vegetable Intake Recommendations AN - 1701475699; PQ0001732767 AB - Most Americans do not eat enough fruits and vegetables with significant variation by state. State-level self-reported frequency of fruit and vegetable consumption is available from the Centers for Disease Control and Prevention's Behavioral Risk Factor Surveillance System (BRFSS). However, BRFSS cannot be used to directly compare states' progress toward national goals because of incongruence in units used to measure intake and because distributions from frequency data are not reflective of usual intake. To help states track progress, we developed scoring algorithms from external data and applied them to BRFSS 2011 data to estimate the percentage of each state's adult population meeting US Department of Agriculture Food Patterns fruit and vegetable intake recommendations. We used 24-hour dietary recall data from the National Health and Nutrition Examination Survey, 2007-2010, to fit sex- and age-specific models that estimate probabilities of meeting recommendations as functions of reported consumption frequency, race/ethnicity, and poverty-income ratio adjusting for intraindividual variation. Regression parameters derived from these models were applied to BRFSS to estimate the percentage meeting recommendations. We estimate that 7%-18% of state populations met fruit recommendations and 5%-12% met vegetable recommendations. Our method provides a new tool for states to track progress toward meeting dietary recommendations. JF - American Journal of Epidemiology AU - Moore, Latetia V AU - Dodd, Kevin W AU - Thompson, Frances E AU - Grimm, Kirsten A AU - Kim, Sonia A AU - Scanlon, Kelley S AD - Correspondence to Dr. Latetia V. Moore, Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F77, Atlanta, GA 30341, lvmoore@cdc.gov Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 979 EP - 988 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 181 IS - 12 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - fruits KW - recommended intake KW - states KW - vegetables KW - Diets KW - Agriculture KW - Fruits KW - Prevention KW - Risk factors KW - Disease control KW - Nutrition KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701475699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Using+Behavioral+Risk+Factor+Surveillance+System+Data+to+Estimate+the+Percentage+of+the+Population+Meeting+US+Department+of+Agriculture+Food+Patterns+Fruit+and+Vegetable+Intake+Recommendations&rft.au=Moore%2C+Latetia+V%3BDodd%2C+Kevin+W%3BThompson%2C+Frances+E%3BGrimm%2C+Kirsten+A%3BKim%2C+Sonia+A%3BScanlon%2C+Kelley+S&rft.aulast=Moore&rft.aufirst=Latetia&rft.date=2015-06-15&rft.volume=181&rft.issue=12&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu461 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Agriculture; Diets; Fruits; Prevention; Risk factors; Disease control; Nutrition; Ethnic groups DO - http://dx.doi.org/10.1093/aje/kwu461 ER - TY - JOUR T1 - Integration of Novel Low-Cost Colorimetric, Laser Photometric, and Visual Fluorescent Techniques for Rapid Identification of Falsified Medicines in Resource-Poor Areas: Application to Artemether-Lumefantrine AN - 1727682899; PQ0002197809 AB - The availability of falsified antimalarial drugs can be reduced with effective drug regulatory agencies and proper enforcement. Fundamental to these agencies taking action, rapid identification must be made as soon as they appear in the market place. Since falsified antimalarials occur mostly in developing countries, performing drug analysis presents itself with unique challenges. A fundamental factor in choosing a useful technique is affordability and simplicity. Therefore, we suggest a three-tiered drug evaluation strategy for identifying a falsified drug in resource-poor areas. Tier I is a simple comparison of a tablet's weight and dimensions with official specifications. Tier II uses inexpensive photometric devices (laser and fluorescence) to evaluate a tablet. Suspicious samples from Tier I and II assessments are then subjected to a colorimetric assay for active ingredients identification and quantification. In this article, we evaluate a novel colorimetric assay for the simultaneous assessment of both lumefantrine and artemether in co-formulated Coartem " tablets, and integrate the method with two novel, low-cost, fluorescence and laser photometric devices. Image analysis software is used for the assessments. Although artemether-lumefantrine is used as an example, the strategy may be adapted to other medicines. JF - American Journal of Tropical Medicine and Hygiene AU - Green, Michael D AU - Hostetler, Dana M AU - Nettey, Henry AU - Swamidoss, Isabel AU - Ranieri, Nicola AU - Newton, Paul N AD - Division of Parasitic Diseases and Malaria, Center for Disease Control, Atlanta, Georgia, mgreen@cdc.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 8 EP - 16 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Fluorescence KW - Tablets KW - Surveillance and enforcement KW - Colorimetry KW - Image processing KW - Drug development KW - Artemether KW - Computer programs KW - Integration KW - software KW - Medicine KW - Lasers KW - Governments KW - Hygiene KW - Drugs KW - Developing countries KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727682899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Integration+of+Novel+Low-Cost+Colorimetric%2C+Laser+Photometric%2C+and+Visual+Fluorescent+Techniques+for+Rapid+Identification+of+Falsified+Medicines+in+Resource-Poor+Areas%3A+Application+to+Artemether-Lumefantrine&rft.au=Green%2C+Michael+D%3BHostetler%2C+Dana+M%3BNettey%2C+Henry%3BSwamidoss%2C+Isabel%3BRanieri%2C+Nicola%3BNewton%2C+Paul+N&rft.aulast=Green&rft.aufirst=Michael&rft.date=2015-06-01&rft.volume=92&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0832 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Surveillance and enforcement; Governments; Lasers; Medicine; Hygiene; Developing countries; Drugs; Integration; Computer programs; software; Fluorescence; Tablets; Image processing; Colorimetry; Drug development; Artemether DO - http://dx.doi.org/10.4269/ajtmh.14-0832 ER - TY - JOUR T1 - Real-Time PCR and Sequencing Assays for Rapid Detection and Identification of Avian Schistosomes in Environmental Samples AN - 1701482478; PQ0001679616 AB - Cercarial dermatitis, also known as swimmer's itch, is an allergenic skin reaction followed by intense itching caused by schistosome cercariae penetrating human skin. Cercarial dermatitis outbreaks occur globally and are frequently associated with freshwater lakes and are occasionally associated with marine or estuarine waters where birds reside year-round or where migratory birds reside. In this study, a broadly reactive TaqMan assay targeting 18S rRNA gene (ribosomal DNA [rDNA]) sequences that was based on a genetically diverse panel of schistosome isolates representing 13 genera and 20 species (the 18S rDNA TaqMan assay) was developed. A PCR assay was also developed to amplify a 28S rDNA region for subsequent sequencing to identify schistosomes. When applied to surface water samples seeded with Schistosoma mansoni cercariae, the 18S rDNA TaqMan assay enabled detection at a level of 5 S. mansoni cercariae in 100 liters of lake water. The 18S rDNA TaqMan and 28S rDNA PCR sequencing assays were also applied to 100-liter water samples collected from lakes in Nebraska and Wisconsin where there were reported dermatitis outbreaks. Avian schistosome DNA was detected in 11 of 34 lake water samples using the TaqMan assay. Further 28S rDNA sequence analysis of positive samples confirmed the presence of avian schistosome DNA and provided a preliminary identification of the avian schistosomes in 10 of the 11 samples. These data indicate that the broadly schistosome-reactive TaqMan assay can be effective for rapid screening of large-volume water samples for detection of avian schistosomes, thereby facilitating timely response actions to mitigate or prevent dermatitis outbreaks. Additionally, samples positive by the 18S rDNA TaqMan assay can be further assayed using the 28S rDNA sequencing assay to both confirm the presence of schistosomes and contribute to their identification. JF - Applied and Environmental Microbiology AU - Jothikumar, Narayanan AU - Mull, Bonnie J AU - Brant, Sara V AU - Loker, Eric S AU - Collinson, Jeremy AU - Secor, W Evan AU - Hill, Vincent R AD - Waterborne Disease Prevention Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, jin2@cdc.gov. PY - 2015 SP - 4207 EP - 4215 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 12 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Schistosoma mansoni KW - rRNA 18S KW - Lakes KW - Skin KW - Data processing KW - Freshwater environments KW - Surface water KW - Nucleotide sequence KW - Recruitment KW - Polymerase chain reaction KW - Dermatitis KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701482478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Real-Time+PCR+and+Sequencing+Assays+for+Rapid+Detection+and+Identification+of+Avian+Schistosomes+in+Environmental+Samples&rft.au=Jothikumar%2C+Narayanan%3BMull%2C+Bonnie+J%3BBrant%2C+Sara+V%3BLoker%2C+Eric+S%3BCollinson%2C+Jeremy%3BSecor%2C+W+Evan%3BHill%2C+Vincent+R&rft.aulast=Jothikumar&rft.aufirst=Narayanan&rft.date=2015-06-01&rft.volume=81&rft.issue=12&rft.spage=4207&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00750-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 31 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - rRNA 18S; Lakes; Data processing; Skin; Surface water; Freshwater environments; Nucleotide sequence; Recruitment; Polymerase chain reaction; Dermatitis; Schistosoma mansoni DO - http://dx.doi.org/10.1128/AEM.00750-15 ER - TY - JOUR T1 - Decreasing Trend in Tobacco-Related Cancer Incidence, United States 2005-2009 AN - 1691295869; PQ0001590970 AB - More than 1 in 3 cancer-related deaths are associated with tobacco use; these include cancers of the lung and bronchus, oral cavity and pharynx, larynx, esophagus, stomach, pancreas, kidney and renal pelvis, urinary bladder, and cervix, and acute myeloid leukemia. In order to characterize the current cancer burden due to tobacco use, this study provides recent trends in tobacco-related cancer incidence across the US. We analyzed data from CDC's National Program of Cancer Registries and NCI's Surveillance, Epidemiology and End Results Program, covering 100 % of the US population during 2005-2009. Age-adjusted incidence rates, 95 % confidence intervals and annual percent change were calculated for each state, the District of Columbia, and the US. Tobacco-related cancer incidence in the US decreased significantly from 152.9 (per 100,000 persons) in 2005 to 145.8 in 2009. Men had higher incidence rates, but a greater decrease in tobacco-related cancers per year over the 5-year time period (-1.4 % in men, compared to -0.8 % in women). Incidence rates decreased the most per year for larynx (-2.4 %), lung and bronchus (-1.9 %) and stomach (-1.5 %) cancers during the study period. Tobacco-related cancer incidence trends varied by state. While tobacco-related cancer incidence in the United States decreased overall from 2005 to 2009, tobacco continued to account for a large cancer burden. Our findings suggest that continued efforts in tobacco prevention and control are needed to further reduce tobacco-related cancer burden in general and among targeted sub-populations in the US. JF - Journal of Community Health AU - Underwood, JMichael AU - Richards, Thomas B AU - Henley, SJane AU - Momin, Behnoosh AU - Houston, Keisha AU - Rolle, Italia AU - Holmes, Carissa AU - Stewart, Sherri L AD - Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, N.E., Atlanta, GA, 30341, USA, jmunderwood@cdc.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 414 EP - 418 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 3 SN - 0094-5145, 0094-5145 KW - Health & Safety Science Abstracts KW - Renal KW - Mortality KW - Leukemia KW - USA KW - Prevention KW - Lung KW - Urinary bladder KW - Tobacco KW - Kidney KW - Cancer KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691295869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Decreasing+Trend+in+Tobacco-Related+Cancer+Incidence%2C+United+States+2005-2009&rft.au=Underwood%2C+JMichael%3BRichards%2C+Thomas+B%3BHenley%2C+SJane%3BMomin%2C+Behnoosh%3BHouston%2C+Keisha%3BRolle%2C+Italia%3BHolmes%2C+Carissa%3BStewart%2C+Sherri+L&rft.aulast=Underwood&rft.aufirst=JMichael&rft.date=2015-06-01&rft.volume=40&rft.issue=3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-014-9951-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 20 N1 - Last updated - 2015-07-23 N1 - SubjectsTermNotLitGenreText - Renal; Leukemia; Mortality; Prevention; Urinary bladder; Lung; Kidney; Tobacco; Cancer; USA DO - http://dx.doi.org/10.1007/s10900-014-9951-6 ER - TY - JOUR T1 - U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. AN - 1690652440; 25884850 AB - Red blood cell (RBC) folate concentrations are a potential biomarker of folate-sensitive neural tube defect (NTD) risk in the population. The purpose of this analysis was to describe women in the U.S. population with RBC folate concentrations below those associated with optimal NTD prevention. We used data from the 2007 to 2012 National Health and Nutrition Examination Survey (NHANES) to assess the RBC folate status of U.S. women of childbearing age relative to risk categories for NTD risk based on RBC folate concentrations. We defined suboptimal RBC folate concentrations as those associated with a prevalence of ≥9 NTDs per 10,000 live births. Among nonpregnant women age 12 to 49 years, 22.8% (95% Confidence Interval: 21.1, 24.6) had suboptimal RBC folate concentrations. Women had greater odds of having a suboptimal RBC folate concentration if they did not use dietary supplements containing folic acid; had mandatorily fortified enriched cereal grain products as their only source of folic acid; were non-Hispanic black or Hispanic; or were current smokers. Based on RBC folate concentrations, we would predict that the majority of U.S. women of reproductive age are not at increased risk for folate sensitive NTDs in the presence of mandatory folic acid fortification. Prevention policies and programs can be aimed at population subgroups identified as having higher predicted risk for folate-sensitive NTDs based on RBC folate concentrations. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Tinker, Sarah C AU - Hamner, Heather C AU - Qi, Yan Ping AU - Crider, Krista S AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia. ; National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 517 EP - 526 VL - 103 IS - 6 KW - Biomarkers KW - 0 KW - Folic Acid KW - 935E97BOY8 KW - Index Medicus KW - folic acid KW - neural tube defects KW - fortification KW - NHANES KW - optimal RBC folate concentration KW - Humans KW - Adult KW - Adolescent KW - United States -- epidemiology KW - Female KW - Pregnancy KW - Erythrocytes -- chemistry KW - Folic Acid -- blood KW - Risk Assessment -- statistics & numerical data KW - Risk Assessment -- methods KW - Biomarkers -- blood KW - Neural Tube Defects -- epidemiology KW - Folic Acid -- analysis KW - Nutrition Surveys -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1690652440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+and+Youth+Care+Forum&rft.atitle=The+Good+Enough+Home%3F+Home+Environment+and+Outcomes+of+Young+Maltreated+Children&rft.au=Robinson%2C+Lara+R%3BBoris%2C+Neil+W%3BHeller%2C+Sherryl+Scott%3BRice%2C+Janet%3BZeanah%2C+Charles+H%3BClark%2C+Cinda%3BHawkins%2C+Shantice&rft.aulast=Robinson&rft.aufirst=Lara&rft.date=2012-02-01&rft.volume=41&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Child+and+Youth+Care+Forum&rft.issn=10531890&rft_id=info:doi/10.1007%2Fs10566-011-9157-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-17 N1 - Date created - 2015-06-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet. 1991 Jul 20;338(8760):131-7 [1677062] MMWR Recomm Rep. 1992 Sep 11;41(RR-14):1-7 [1522835] N Engl J Med. 1992 Dec 24;327(26):1832-5 [1307234] JAMA. 1995 Dec 6;274(21):1698-702 [7474275] JAMA. 1996 Apr 24;275(16):1233-40 [8601954] Pediatrics. 2005 Sep;116(3):580-6 [16140696] Birth Defects Res A Clin Mol Teratol. 2006 Nov;76(11):747-56 [17051527] Birth Defects Res A Clin Mol Teratol. 2008 Apr;82(4):211-6 [18338391] Am J Clin Nutr. 2008 Jul;88(1):232-46 [18614746] Am J Epidemiol. 2009 Jan 1;169(1):9-17 [18953063] Ann Intern Med. 2009 May 5;150(9):626-31 [19414842] Am J Clin Nutr. 2010 Jan;91(1):64-72 [19828716] Am J Prev Med. 2010 May;38(5):534-42 [20347553] Birth Defects Res A Clin Mol Teratol. 2010 Dec;88(12):1008-16 [20878909] J Nutr. 2011 Jul;141(7):1402-9 [21613453] Epidemiology. 2011 Sep;22(5):731-7 [21659881] J Nutr. 2012 May;142(5):886-93 [22437563] J Nutr. 2013 Jun;143(6):948S-56S [23596165] BMJ. 2014;349:g4554 [25073783] Vital Health Stat 2. 2013 Sep;(161):1-24 [25090154] MMWR Morb Mortal Wkly Rep. 2015 Jan 16;64(1):1-5 [25590678] N Engl J Med. 2007 Jul 12;357(2):135-42 [17625125] N Engl J Med. 1999 Nov 11;341(20):1485-90 [10559448] MMWR Morb Mortal Wkly Rep. 2004 May 7;53(17):362-5 [15129193] Comment In: Birth Defects Res A Clin Mol Teratol. 2015 Jun;103(6):469-70 [25884960] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23378 ER - TY - JOUR T1 - HIV, Chlamydia, Gonorrhea, and Primary and Secondary Syphilis among American Indians and Alaska Natives Within Indian Health Service Areas in the United States, 2007-2010 AN - 1687668419; PQ0001590980 AB - National rates from human immunodeficiency virus (HIV) and sexually transmitted disease (STD) surveillance may not effectively convey the impact of HIV and STDs on American Indian/Alaska Native (AI/AN) communities. Instead, we compared average annual diagnosis rates per 100,000 population of HIV, chlamydia (CT), gonorrhea (GC), and primary and secondary (P&S) syphilis, from 2007 to 2010, among AI/AN aged greater than or equal to 13 years residing in 625 counties in the 12 Indian Health Service Areas, all AI/AN, and all races/ethnicities to address this gap. AI/AN comprised persons reported as AI/AN only, with or without Hispanic ethnicity. Out of 12 IHS Areas, 10 had higher case rates for CT, 3 for GC, and 4 for P&S syphilis compared to rates for all races/ethnicities. Eight Areas had higher HIV diagnosis rates than for all AI/AN, but HIV rates for all IHS Areas were lower than national rates for all races/ethnicities. Two IHS Areas ranking highest in rates of CT and GC and four Areas with highest P&S syphilis also had high HIV rates. STD and HIV rates among AI/AN were greater in certain IHS Areas than expected from observing national rates for AI/AN. Integrated surveillance of overlapping trends in STDs and HIV may be useful in guiding prevention efforts for AI/AN populations. JF - Journal of Community Health AU - Walker, Frances J AU - Llata, Eloisa AU - Doshani, Mona AU - Taylor, Melanie M AU - Bertolli, Jeanne AU - Weinstock, Hillard S AU - Hall, HIrene AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA, gge3@cdc.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 484 EP - 492 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 3 SN - 0094-5145, 0094-5145 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Guanylate cyclase KW - Sexually-transmitted diseases KW - Human immunodeficiency virus KW - Treponema pallidum KW - Gonorrhea KW - Syphilis KW - Ethnic groups KW - Races KW - Chlamydia KW - J 02410:Animal Diseases KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687668419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=HIV%2C+Chlamydia%2C+Gonorrhea%2C+and+Primary+and+Secondary+Syphilis+among+American+Indians+and+Alaska+Natives+Within+Indian+Health+Service+Areas+in+the+United+States%2C+2007-2010&rft.au=Walker%2C+Frances+J%3BLlata%2C+Eloisa%3BDoshani%2C+Mona%3BTaylor%2C+Melanie+M%3BBertolli%2C+Jeanne%3BWeinstock%2C+Hillard+S%3BHall%2C+HIrene&rft.aulast=Walker&rft.aufirst=Frances&rft.date=2015-06-01&rft.volume=40&rft.issue=3&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-014-9961-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Number of references - 44 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Guanylate cyclase; Sexually-transmitted diseases; Gonorrhea; Syphilis; Races; Ethnic groups; Human immunodeficiency virus; Treponema pallidum; Chlamydia DO - http://dx.doi.org/10.1007/s10900-014-9961-4 ER - TY - JOUR T1 - Clinical interventions to reduce secondhand smoke exposure among pregnant women: a systematic review AN - 1808712765; PQ0003431015 AB - ObjectiveTo conduct a systematic review of clinical interventions to reduce secondhand smoke (SHS) exposure among non-smoking pregnant women.Data sourcesWe searched 16 databases for publications from 1990 to January 2013, with no language restrictions.Study selectionPapers were included if they met the following criteria: (1) the study population included non-smoking pregnant women exposed to SHS, (2) the clinical interventions were intended to reduce SHS exposure at home, (3) the study included a control group and (4) outcomes included either reduced SHS exposure of non-smoking pregnant women at home or quit rates among smoking partners during the pregnancy of the woman.Data extractionTwo coders independently reviewed each abstract or full text to identify eligible papers. Two abstractors independently coded papers based on US Preventive Services Task Force criteria for study quality (good, fair, poor), and studies without biochemically-verified outcome measures were considered poor quality.Data synthesisFrom 4670 papers, we identified five studies that met our inclusion criteria: four focused on reducing SHS exposure among non-smoking pregnant women, and one focused on providing cessation support for smoking partners of pregnant women. All were randomised controlled trials, and all reported positive findings. Three studies were judged poor quality because outcome measures were not biochemically-verified, and two were considered fair quality.ConclusionsClinical interventions delivered in prenatal care settings appear to reduce SHS exposure, but study weaknesses limit our ability to draw firm conclusions. More rigorous studies, using biochemical validation, are needed to identify strategies for reducing SHS exposure in pregnant women. JF - Tobacco Control AU - Tong, Van T AU - Dietz, Patricia M AU - Rolle, Italia V AU - Kennedy, Sara M AU - Thomas, William AU - England, Lucinda J AD - Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, , Atlanta, Georgia, USA Y1 - 2015/05/30/ PY - 2015 DA - 2015 May 30 SP - 217 EP - 223 PB - BMJ Publishing Group Ltd. VL - 24 IS - 3 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Environmental tobacco smoke KW - secondhand smoke KW - non-smoking pregnant women KW - pregnancy KW - partner cessation KW - clinical interventions KW - Smoke KW - Smoking KW - Databases KW - Prenatal experience KW - Reviews KW - Tobacco KW - Population studies KW - Language KW - Clinical trials KW - Pregnancy KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808712765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Clinical+interventions+to+reduce+secondhand+smoke+exposure+among+pregnant+women%3A+a+systematic+review&rft.au=Tong%2C+Van+T%3BDietz%2C+Patricia+M%3BRolle%2C+Italia+V%3BKennedy%2C+Sara+M%3BThomas%2C+William%3BEngland%2C+Lucinda+J&rft.aulast=Tong&rft.aufirst=Van&rft.date=2015-05-30&rft.volume=24&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2013-051200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Smoke; Databases; Smoking; Prenatal experience; Reviews; Tobacco; Population studies; Language; Clinical trials; Pregnancy DO - http://dx.doi.org/10.1136/tobaccocontrol-2013-051200 ER - TY - CPAPER T1 - Use of Smartphone Sound Measurement Apps for Occupational Noise Assessments T2 - 169th Meeting of the Acoustical Society of America AN - 1669823919; 6341645 JF - 169th Meeting of the Acoustical Society of America AU - Kardous, Chucri AU - Celestina, Metod Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Sound measurement KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Use+of+Smartphone+Sound+Measurement+Apps+for+Occupational+Noise+Assessments&rft.au=Dave%2C+Dhaval+M%3BDecker%2C+Sandra+L%3BKaestner%2C+Robert%3BSimon%2C+Kosali+Ilayperuma&rft.aulast=Dave&rft.aufirst=Dhaval&rft.date=2010-01-01&rft.volume=47&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Inquiry+%28Rochester%29&rft.issn=00469580&rft_id=info:doi/10.5034%2Finquiryjrnl_47.04.315 L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Epidemiology of imported malaria in Quanzhou in 2002-2013 AN - 1776641830; PQ0002740072 AB - Objective To discuss the epidemiological characteristics of imported malaria in Quanzhou from 2002 to 2013. Methods Data of patients with imported malaria were analyzed by SPSS 18.0,and chi-square test was used for statistical analysis. Results A total of 64 cases with imported malaria were reported during a12 year period,including 23 cases of plasmodium falciparum,35 cases of plasmodium vivax and 6unknown type of plasmodium.76.56% of cases were 20 to 49years old,and male to female ratio was 6.11:1.Farmers accounted for 37.50% of total cases,followed by migrant workers(21.88%)and commercial service individuals(10.93%).Plasmodium vivaxand Plasmodium falciparum were predominant among patients with malaria diagnosed in 2002-2008 and in 2010-2013,respectively.Imported malaria cases from mainland and Asia were mainly infected with Plasmodium vivax,while patients from Africa were infected with Plasmodium falciparum,the difference was significant. Conclusions No patient with malaria has been found locally infected during 12 year period in Quanzhou,however,imported cases are reported each year.Therefore,it is critical to strengthen the prevention and control of imported malaria. JF - Zhongguo Yufang Yixue Zazhi - Chinese Preventive Medicine AU - Chen, Hai-yan AD - Quanzhou Center for Disease Control and Prevention Y1 - 2015/05// PY - 2015 DA - May 2015 PB - Zhonghua Yufang Yixuehui VL - 16 IS - 5 SN - 1009-6639, 1009-6639 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Health & Safety Science Abstracts KW - Malaria KW - Imported case KW - Epidemiology KW - Parasites KW - Human diseases KW - Data processing KW - Statistical analysis KW - Plasmodium vivax KW - Plasmodium falciparum KW - Public health KW - Methodology KW - Prevention KW - Africa KW - Asia KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - H 12000:Epidemiology and Public Health KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776641830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Yufang+Yixue+Zazhi+-+Chinese+Preventive+Medicine&rft.atitle=Epidemiology+of+imported+malaria+in+Quanzhou+in+2002-2013&rft.au=Chen%2C+Hai-yan&rft.aulast=Chen&rft.aufirst=Hai-yan&rft.date=2015-05-01&rft.volume=16&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Yufang+Yixue+Zazhi+-+Chinese+Preventive+Medicine&rft.issn=10096639&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Epidemiology; Malaria; Methodology; Public health; Data processing; Statistical analysis; Prevention; Plasmodium vivax; Plasmodium falciparum; Africa; Asia ER - TY - JOUR T1 - Tuberculosis and vitamin D: what's the rest of the story? AN - 1773825175; PQ0001709365 JF - Lancet Infectious Diseases AU - Cegielski, Peter AU - Vernon, Andrew AD - Division of Tuberculosis Elimination, The National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, US Centers for Disease Control and Prevention, Atlanta, GA 30329, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 489 EP - 490 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 15 IS - 5 SN - 1473-3099, 1473-3099 KW - Microbiology Abstracts B: Bacteriology KW - Vitamin D KW - Mycobacterium KW - Tuberculosis KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773825175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+Infectious+Diseases&rft.atitle=Tuberculosis+and+vitamin+D%3A+what%27s+the+rest+of+the+story%3F&rft.au=Cegielski%2C+Peter%3BVernon%2C+Andrew&rft.aulast=Cegielski&rft.aufirst=Peter&rft.date=2015-05-01&rft.volume=15&rft.issue=5&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Lancet+Infectious+Diseases&rft.issn=14733099&rft_id=info:doi/10.1016%2FS1473-3099%2815%2970163-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 14 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Vitamin D; Tuberculosis; Mycobacterium DO - http://dx.doi.org/10.1016/S1473-3099(15)70163-5 ER - TY - JOUR T1 - The Influence of Diet on the Use of Near-Infrared Spectroscopy to Determine the Age of Female Aedes aegypti Mosquitoes AN - 1727684723; PQ0002118770 AB - Interventions targeting adult mosquitoes are used to combat transmission of vector-borne diseases, including dengue. Without available vaccines, targeting the primary vector, Aedes aegypti, is essential to prevent transmission. Older mosquitoes (> or = 7 days) are of greatest epidemiological significance due to the 7-day extrinsic incubation period of the virus. Age-grading of female mosquitoes is necessary to identify post-intervention changes in mosquito population age structure. We developed models using near-infrared spectroscopy (NIRS) to age-grade adult female Ae. aegypti. To determine if diet affects the ability of NIRS models to predict age, two identical larval groups were fed either fish food or Infant cereal. Adult females were separated and fed sugar water + or - blood, resulting in four experimental groups. Females were killed 1, 4, 7, 10, 13, or 16 days postemergence. The head/thorax of each mosquito was scanned using a near-infrared spectrometer. Scans from each group were analyzed, and multiple models were developed using partial least squares regression. The best model included all experimental groups, and positively predicted the age group ( or = 7 days) of 90.2% mosquitoes. These results suggest both larval and adult diets can affect the ability of NIRS models to accurately assign age categories to female Ae. aegypti. JF - American Journal of Tropical Medicine and Hygiene AU - Liebman, Kelly AU - Swamidoss, Isabel AU - Vizcaino, Lucrecia AU - Lenhart, Audrey AU - Dowell, Floyd AU - Wirtz, Robert AD - Centers for Disease Control and Prevention, Atlanta, Georgia, wuq4@cdc.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1070 EP - 1075 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Entomology Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Aedes aegypti KW - Age KW - Food KW - Vector-borne diseases KW - Larval development KW - Models KW - Public health KW - Disease transmission KW - Cereals KW - Dengue KW - I.R. spectroscopy KW - Regression analysis KW - Thorax KW - Aquatic insects KW - Diets KW - Sugar KW - Age composition KW - I.R. radiation KW - Head KW - Vectors KW - Age determination KW - Blood KW - Feeding experiments KW - Vaccines KW - Hygiene KW - Infants KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - J 02400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727684723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Influence+of+Diet+on+the+Use+of+Near-Infrared+Spectroscopy+to+Determine+the+Age+of+Female+Aedes+aegypti+Mosquitoes&rft.au=Liebman%2C+Kelly%3BSwamidoss%2C+Isabel%3BVizcaino%2C+Lucrecia%3BLenhart%2C+Audrey%3BDowell%2C+Floyd%3BWirtz%2C+Robert&rft.aulast=Liebman&rft.aufirst=Kelly&rft.date=2015-05-01&rft.volume=92&rft.issue=5&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Diets; Feeding experiments; Vaccines; Age determination; Hygiene; Larval development; Aquatic insects; Disease transmission; Public health; Sugar; Age composition; Age; I.R. radiation; Head; Food; Vector-borne diseases; Vectors; Models; Blood; Cereals; I.R. spectroscopy; Dengue; Thorax; Regression analysis; Infants; Aedes aegypti DO - http://dx.doi.org/10.4269/ajtmh.14-0790 ER - TY - JOUR T1 - Meteorological Conditions Associated with Increased Incidence of West Nile Virus Disease in the United States, 2004-2012 AN - 1727684409; PQ0002118762 AB - West Nile virus (WNV) is a leading cause of mosquito-borne disease in the United States. Annual seasonal outbreaks vary in size and location. Predicting where and when higher than normal WNV transmission will occur can help direct limited public health resources. We developed models for the contiguous United States to identify meteorological anomalies associated with above average incidence of WNV neuroinvasive disease from 2004 to 2012. We used county-level WNV data reported to ArboNET and meteorological data from the North American Land Data Assimilation System. As a result of geographic differences in WNV transmission, we divided the United States into East and West, and 10 climate regions. Above average annual temperature was associated with increased likelihood of higher than normal WNV disease incidence, nationally and in most regions. Lower than average annual total precipitation was associated with higher disease incidence in the eastern United States, but the opposite was true in most western regions. Although multiple factors influence WNV transmission, these findings show that anomalies in temperature and precipitation are associated with above average WNV disease incidence. Readily accessible meteorological data may be used to develop predictive models to forecast geographic areas with elevated WNV disease risk before the coming season. JF - American Journal of Tropical Medicine and Hygiene AU - Hahn, Micah B AU - Monaghan, Andrew J AU - Hayden, Mary H AU - Eisen, Rebecca J AU - Delorey, Mark J AU - Lindsey, Nicole P AU - Nasci, Roger S AU - Fischer, Marc AD - National Center for Atmospheric Research, Boulder, Colorado, mfischer@cdc.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1013 EP - 1022 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 5 SN - 0002-9637, 0002-9637 KW - Meteorological & Geoastrophysical Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Prediction KW - Temperature effects KW - Meteorological data KW - Invasiveness KW - Data processing KW - Climate KW - Precipitation KW - Data assimilation KW - Disease transmission KW - Public health KW - USA KW - Seasonal variability KW - Hygiene KW - Meteorological conditions KW - Aquatic insects KW - West Nile virus KW - K 03410:Animal Diseases KW - J 02400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - M2 551.509.1/.5:Forecasting (551.509.1/.5) KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727684409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Meteorological+Conditions+Associated+with+Increased+Incidence+of+West+Nile+Virus+Disease+in+the+United+States%2C+2004-2012&rft.au=Hahn%2C+Micah+B%3BMonaghan%2C+Andrew+J%3BHayden%2C+Mary+H%3BEisen%2C+Rebecca+J%3BDelorey%2C+Mark+J%3BLindsey%2C+Nicole+P%3BNasci%2C+Roger+S%3BFischer%2C+Marc&rft.aulast=Hahn&rft.aufirst=Micah&rft.date=2015-05-01&rft.volume=92&rft.issue=5&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0737 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Temperature effects; Prediction; Meteorological data; Climate; Hygiene; Aquatic insects; Public health; Disease transmission; Invasiveness; Data processing; Seasonal variability; Precipitation; Data assimilation; Meteorological conditions; West Nile virus; USA DO - http://dx.doi.org/10.4269/ajtmh.14-0737 ER - TY - JOUR T1 - Comparison of Antimicrobial Susceptibilities of Pharyngeal, Rectal, and Urethral Neisseria gonorrhoeae Isolates among Men Who Have Sex with Men AN - 1683352524; PQ0001539696 AB - U.S. surveillance for Neisseria gonorrhoeae antimicrobial susceptibilities is based exclusively on male urethral isolates. These data inform gonorrhea treatment guidelines, including recommendations for the treatment of extragenital infections, but data on the susceptibilities of extragenital isolates are limited. We compared the antimicrobial susceptibilities of pharyngeal, rectal, and urethral gonococcal isolates collected from men who have sex with men (MSM), at five sentinel sites throughout the United States. MICs were determined by the agar dilution method. Generalized linear models were used to compare (i) the proportions of isolates with elevated MICs and (ii) geometric mean MICs according to anatomic site, adjusted for city. In December 2011 to September 2013, totals of 205 pharyngeal, 261 rectal, and 976 urethral isolates were obtained. The proportions of isolates with elevated ceftriaxone MICs ( greater than or equal to 0.125 mu g/ml) did not differ according to anatomic site (0.5% of pharyngeal isolates, 1.5% of rectal isolates, and 1.7% of urethral isolates, with a city-adjusted odds ratio [aOR] of 0.4 [95% confidence interval {CI}, 0.0 to 3.9] for pharyngeal versus urethral isolates and an aOR of 0.9 [95% CI, 0.2 to 4.2] for rectal versus urethral isolates). The city-adjusted geometric mean ceftriaxone MICs of pharyngeal (0.0153 mu g/ml) and rectal (0.0157 mu g/ml) isolates did not differ from that of urethral isolates (0.0150 mu g/ml) (ratios of geometric mean MICs of 1.02 [95% CI, 0.90 to 1.17] and 1.05 [95% CI, 0.93 to 1.19], respectively). Similar results were observed for other antimicrobials, including cefixime and azithromycin. These findings suggest that, at the population level, gonococcal antimicrobial susceptibility surveillance based on urethral isolates from MSM adequately reflects the susceptibilities of N. gonorrhoeae strains circulating among MSM. JF - Antimicrobial Agents & Chemotherapy AU - Kidd, Sarah AU - Zaidi, Akbar AU - Asbel, Lenore AU - Baldwin, Tamara AU - Gratzer, Beau AU - Guerry, Sarah AU - Kerani, Roxanne P AU - Pathela, Preeti AU - Pettus, Kevin AU - Soge, Olusegun O AD - Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, skidd@cdc.gov. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 2588 EP - 2595 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 5 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Data processing KW - Pharynx KW - Rectum KW - Ceftriaxone KW - Infection KW - Minimum inhibitory concentration KW - Neisseria gonorrhoeae KW - Models KW - Antimicrobial agents KW - Azithromycin KW - Cefixime KW - Gonorrhea KW - Population levels KW - Sex KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683352524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Comparison+of+Antimicrobial+Susceptibilities+of+Pharyngeal%2C+Rectal%2C+and+Urethral+Neisseria+gonorrhoeae+Isolates+among+Men+Who+Have+Sex+with+Men&rft.au=Kidd%2C+Sarah%3BZaidi%2C+Akbar%3BAsbel%2C+Lenore%3BBaldwin%2C+Tamara%3BGratzer%2C+Beau%3BGuerry%2C+Sarah%3BKerani%2C+Roxanne+P%3BPathela%2C+Preeti%3BPettus%2C+Kevin%3BSoge%2C+Olusegun+O&rft.aulast=Kidd&rft.aufirst=Sarah&rft.date=2015-05-01&rft.volume=59&rft.issue=5&rft.spage=2588&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04476-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 38 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Agar; Rectum; Pharynx; Data processing; Ceftriaxone; Infection; Minimum inhibitory concentration; Antimicrobial agents; Models; Azithromycin; Cefixime; Population levels; Gonorrhea; Sex; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.04476-14 ER - TY - JOUR T1 - Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses AN - 1683350072; PQ0001540013 AB - Human infections by avian influenza A(H7N9) virus entail substantial morbidity and mortality. Treatment of infected patients with the neuraminidase (NA) inhibitor oseltamivir was associated with emergence of viruses carrying NA substitutions. In the NA inhibition (NI) assay, R292K conferred highly reduced inhibition by oseltamivir, while E119V and I222K each caused reduced inhibition. To facilitate establishment of laboratory correlates of clinically relevant resistance, experiments were conducted in ferrets infected with virus carrying wild-type or variant NA genes recovered from the A/Taiwan/1/2013 isolate. Oseltamivir treatment (5 or 25 mg/kg of body weight/dose) was given 4 h postinfection, followed by twice-daily treatment for 5 days. Treatment of ferrets infected with wild-type virus resulted in a modest dose-dependent reduction (0.7 to 1.5 log10 50% tissue culture infectious dose [TCID50]) in nasal wash viral titers and inflammation response. Conversely, treatment failed to significantly inhibit the replication of R292K or E119V virus. A small reduction of viral titers was detected on day 5 in ferrets infected with the I222K virus. The propensity for oseltamivir resistance emergence was assessed in oseltamivir-treated animals infected with wild-type virus; emergence of R292K virus was detected in 3 of 6 ferrets within 5 to 7 days postinfection. Collectively, we demonstrate that R292K, E119V, and I222K reduced the inhibitory activity of oseltamivir, not only in the NI assay, but also in infected ferrets, judged particularly by viral loads in nasal washes, and may signal the need for alternative therapeutics. Thus, these clinical outcomes measured in the ferret model may correlate with clinically relevant oseltamivir resistance in humans. IMPORTANCE This report provides more evidence for using the ferret model to assess the susceptibility of influenza A(H7N9) viruses to oseltamivir, the most prescribed anti-influenza virus drug. The information gained can be used to assist in the establishment of laboratory correlates of human disease and drug therapy. The rapid emergence of viruses with R292K in treated ferrets correlates well with the multiple reports on this NA variant in treated human patients. Our findings highlight the importance of the discovery and characterization of new antiviral drugs with different mechanisms of action and the use of combination treatment strategies against emerging viruses with pandemic potential, such as avian H7N9 virus, particularly against those carrying drug resistance markers. JF - Journal of Virology AU - Marjuki, Henju AU - Mishin, Vasiliy P AU - Chesnokov, Anton P AU - De La Cruz, Juan A AU - Davis, Charles T AU - Villanueva, Julie M AU - Fry, Alicia M AU - Gubareva, Larisa V AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, lgubareva@cdc.gov. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 5419 EP - 5426 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 10 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Drug resistance KW - Viruses KW - Disease resistance KW - Infection KW - Morbidity KW - Models KW - Influenza KW - pandemics KW - Mustela KW - Antiviral agents KW - Body weight KW - Exo- alpha -sialidase KW - Drugs KW - Mortality KW - Laboratory testing KW - Replication KW - Tissue culture KW - Inflammation KW - Oseltamivir KW - Fowl plague KW - ISEW, Taiwan KW - Mutation KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683350072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Neuraminidase+Mutations+Conferring+Resistance+to+Oseltamivir+in+Influenza+A%28H7N9%29+Viruses&rft.au=Marjuki%2C+Henju%3BMishin%2C+Vasiliy+P%3BChesnokov%2C+Anton+P%3BDe+La+Cruz%2C+Juan+A%3BDavis%2C+Charles+T%3BVillanueva%2C+Julie+M%3BFry%2C+Alicia+M%3BGubareva%2C+Larisa+V&rft.aulast=Marjuki&rft.aufirst=Henju&rft.date=2015-05-01&rft.volume=89&rft.issue=10&rft.spage=5419&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03513-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 40 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mortality; Replication; Drug resistance; Disease resistance; Tissue culture; Infection; Morbidity; Oseltamivir; Models; Inflammation; Influenza; Fowl plague; pandemics; Body weight; Antiviral agents; Exo- alpha -sialidase; Mutation; Laboratory testing; Viruses; Drugs; Mustela; ISEW, Taiwan DO - http://dx.doi.org/10.1128/JVI.03513-14 ER - TY - JOUR T1 - The impact of adherence to preexposure prophylaxis on the risk of HIV infection among people who inject drugs AN - 1808693039; PQ0003241730 AB - Objective: To describe participant adherence to daily oral tenofovir in an HIV preexposure prophylaxis (PrEP) trial, examine factors associated with adherence, and assess the impact of adherence on the risk of HIV infection. Design: The Bangkok Tenofovir Study was a randomized, double-blind, placebo-controlled trial conducted among people who inject drugs, 2005-2012. Methods: Participants chose daily visits or monthly visits. Study nurses observed participants swallow study drug and both initialed a diary. We assessed adherence using the diary. We examined adherence by age group and sex and used logistic regression to evaluate demographics and risk behaviors as predictors of adherence and Cox regression to assess the impact of adherence on the risk of HIV infection. Results: A total of 2413 people enrolled and contributed 9665 person-years of follow-up (mean 4.0 years, maximum 6.9 years). The risk of HIV infection decreased as adherence improved, from 48.9% overall to 83.5% for those with at least 97.5% adherence. In multivariable analysis, men were less adherent than women (P=0.006) and participants 20-29 years old (P<0.001) and 30-39 years old (P=0.01) were less adherent than older participants. Other factors associated with poor adherence included incarceration (P=0.02) and injecting methamphetamine (P=0.04). Conclusion: In this HIV PrEP trial among people who inject drugs, improved adherence to daily tenofovir was associated with a lower risk of HIV infection. This is consistent with trials among MSM and HIV-discordant heterosexual couples and suggests that HIV PrEP can provide a high level of protection from HIV infection. JF - AIDS AU - Martin, Michael AU - Vanichseni, Suphak AU - Suntharasamai, Pravan AU - Sangkum, Udomsak AU - Mock, Philip A AU - Leethochawalit, Manoj AU - Chiamwongpaet, Sithisat AU - Curlin, Marcel E AU - Na-pompet, Supawadee AU - Warapronmongkholkul, Anchalee AD - Thailand MOPH - US CDC Collaboration, Nonthaburi, Thailand, Znd9@cdc.gov Y1 - 2015/04/24/ PY - 2015 DA - 2015 Apr 24 SP - 819 EP - 824 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 29 IS - 7 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - adherence KW - HIV KW - people who inject drugs KW - preexposure prophylaxis KW - tenofovir KW - Risk assessment KW - Acquired immune deficiency syndrome KW - Age KW - Risk taking KW - Thailand, Chacoengsao Prov., Bangkok KW - Infection KW - Drug abuse KW - Clinical trials KW - Medical personnel KW - Demography KW - Nursing KW - Risk factors KW - Drugs KW - Sex KW - Drug development KW - Health risks KW - Methamphetamine KW - Human immunodeficiency virus KW - Prophylaxis KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808693039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=The+impact+of+adherence+to+preexposure+prophylaxis+on+the+risk+of+HIV+infection+among+people+who+inject+drugs&rft.au=Martin%2C+Michael%3BVanichseni%2C+Suphak%3BSuntharasamai%2C+Pravan%3BSangkum%2C+Udomsak%3BMock%2C+Philip+A%3BLeethochawalit%2C+Manoj%3BChiamwongpaet%2C+Sithisat%3BCurlin%2C+Marcel+E%3BNa-pompet%2C+Supawadee%3BWarapronmongkholkul%2C+Anchalee&rft.aulast=Martin&rft.aufirst=Michael&rft.date=2015-04-24&rft.volume=29&rft.issue=7&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000613 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Demography; Age; Methamphetamine; Risk factors; Prophylaxis; Drug development; tenofovir; Drug abuse; Infection; Sex; Risk assessment; Acquired immune deficiency syndrome; Risk taking; Clinical trials; Medical personnel; Health risks; Human immunodeficiency virus; Nursing; Drugs; Thailand, Chacoengsao Prov., Bangkok DO - http://dx.doi.org/10.1097/QAD.0000000000000613 ER - TY - JOUR T1 - Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F/A). AN - 1671217933; 25731972 AB - A unique strain of Clostridium botulinum (IBCA10-7060) was recently discovered which produces two toxins: botulinum neurotoxin (BoNT) serotype B and a novel BoNT reported as serotype H. Previous molecular assessment showed that the light chain (LC) of the novel BoNT most resembled the bont of the light chain of known subtype F5, while the C-terminus of the heavy chain (HC) most resembled the binding domain of serotype A. We evaluated the functionality of both toxins produced in culture by first incorporating an immunoaffinity step using monoclonal antibodies to purify BoNT from culture supernatants and tested each immune-captured neurotoxin with full-length substrates vesicle-associated membrane protein 2 (VAMP-2), synaptosomal-associated protein 25 (SNAP-25), syntaxin, and shortened peptides representing the substrates. The BoNT/B produced by this strain behaved as a typical BoNT/B, having immunoaffinity for anti-B monoclonal antibodies and cleaving both full length VAMP-2 and a peptide based on the sequence of VAMP-2 in the expected location. As expected, there was no activity toward SNAP-25 or syntaxin. The novel BoNT demonstrated immunoaffinity for anti-A monoclonal antibodies but did not cleave SNAP-25 as expected for BoNT/A. Instead, the novel BoNT cleaved VAMP-2 and VAMP-2-based peptides in the same location as BoNT/F5. This is the first discovery of a single botulinum neurotoxin with BoNT/A antigenicity and BoNT/F light chain function. This work suggests that the newly reported serotype H may actually be a hybrid of previously known BoNT serotype A and serotype F, specifically subtype F5. JF - Analytical chemistry AU - Kalb, Suzanne R AU - Baudys, Jakub AU - Raphael, Brian H AU - Dykes, Janet K AU - Lúquez, Carolina AU - Maslanka, Susan E AU - Barr, John R AD - †Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Hwy NE, Atlanta, Georgia 30341, United States. ; ‡Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Enteric Diseases Laboratory Branch, 1600 Clifton Road, Atlanta, Georgia 30329, United States. Y1 - 2015/04/07/ PY - 2015 DA - 2015 Apr 07 SP - 3911 EP - 3917 VL - 87 IS - 7 KW - botulinum toxin type F KW - 0 KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Mass Spectrometry KW - Chromatography, Liquid KW - Botulinum Toxins, Type A -- metabolism KW - Clostridium botulinum -- metabolism KW - Botulinum Toxins -- chemistry KW - Botulinum Toxins -- metabolism KW - Clostridium botulinum -- chemistry KW - Botulinum Toxins, Type A -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671217933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Functional+characterization+of+botulinum+neurotoxin+serotype+H+as+a+hybrid+of+known+serotypes+F+and+A+%28BoNT+F%2FA%29.&rft.au=Kalb%2C+Suzanne+R%3BBaudys%2C+Jakub%3BRaphael%2C+Brian+H%3BDykes%2C+Janet+K%3BL%C3%BAquez%2C+Carolina%3BMaslanka%2C+Susan+E%3BBarr%2C+John+R&rft.aulast=Kalb&rft.aufirst=Suzanne&rft.date=2015-04-07&rft.volume=87&rft.issue=7&rft.spage=3911&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac504716v LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-09 N1 - Date created - 2015-04-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Emerg Infect Dis. 2005 Oct;11(10):1578-83 [16318699] Biochim Biophys Acta. 1996 Jun 7;1307(2):123-6 [8679691] J Biol Chem. 1996 Mar 29;271(13):7694-9 [8631808] Biochemistry. 1996 Feb 27;35(8):2630-6 [8611567] J Biol Chem. 1995 May 5;270(18):10566-70 [7737992] J Biol Chem. 1994 Aug 12;269(32):20213-6 [8051110] Biochem Biophys Res Commun. 1994 Apr 29;200(2):829-35 [7910017] J Biol Chem. 1994 Apr 29;269(17):12764-72 [8175689] J Biol Chem. 1994 Jan 21;269(3):1617-20 [8294407] FEBS Lett. 1993 Nov 29;335(1):99-103 [8243676] J Biol Chem. 1993 Nov 15;268(32):23784-7 [8226912] EMBO J. 1993 Dec;12(12):4821-8 [7901002] Nature. 1993 Sep 9;365(6442):160-3 [8103915] J Biol Chem. 1993 Jun 5;268(16):11516-9 [8505288] Nature. 1992 Oct 29;359(6398):832-5 [1331807] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11346-50 [12177434] Anal Chem. 2014 Apr 1;86(7):3254-62 [24605815] J Infect Dis. 2014 Jan 15;209(2):183-91 [24106296] FEBS Lett. 2012 Jan 20;586(2):109-15 [22172278] FEMS Immunol Med Microbiol. 2011 Apr;61(3):288-300 [21205003] Appl Environ Microbiol. 2011 Feb;77(4):1301-8 [21169446] Appl Environ Microbiol. 2010 Jul;76(14):4805-12 [20511432] Nat Biotechnol. 2007 Jan;25(1):107-16 [17173035] J Bacteriol. 2007 Feb;189(3):818-32 [17114256] PLoS One. 2009;4(4):e5355 [19399171] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ac504716v ER - TY - JOUR T1 - The composition of intestinal microbiota in women with perimenopausal syndrome AN - 1805508825; PQ0002897606 AB - Objective To detect qualitatively and quantitatively the intestinal microbiota in women with perimenopausal syntrome in order to learn the microecological status and characteristics of the intestinal microbiota and provide data for researches on novel ways of treating and preventing perimenopausal syndrome. Methods An experimental group including women with perimenopausal syndrome and a control group including similar-aged healthy female volunteers were set. Mitsuoka method was used for detection of intestinal microbiota,including Bifidobcteria,Lactobacilli,Bacteriodes,C. perfringens,Peptostreptococci,Enterobacteriaceae,Enterococci and Yeasts,and the ratio of Bifidobcteria to Enterobacteriaceae( B/E ratio) was calculated. Results Compared with the control group,the number of Bifidobcteria in subjects with perimenopausal syndrome markedly reduced( P < 0. 01) and the B/E ratio was also significantly lower( P < 0. 01),while the numbers of Enterobacteriaceae,Enterococci and Peptostreptococci significantly increased( P < 0. 01,P < 0. 01,P < 0. 05 respectively). Conclusion The composition of intesninal microbiota in women with perimenopausal syndrome significantly changed,with the number of Bifidobcteria markedly declining while Enterobacteriaceae and Peptostreptococci increasing; the reason might be the intestinal microbiota dysbiosis resulted from neuroendocrine disorders in women with perimenopausal syndrome. JF - Chinese Journal of Microecology AU - Guo, Zai-qing AD - Center for Disease Control of Huangmei County Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 477 EP - 479 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 27 IS - 4 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Microbiota KW - Perimenoparsal syndrome KW - Bifidobacteria KW - Enterobacteriaceae KW - Dysbiosis KW - Intestinal microflora KW - Data processing KW - Intestine KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805508825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Microecology&rft.atitle=The+composition+of+intestinal+microbiota+in+women+with+perimenopausal+syndrome&rft.au=Guo%2C+Zai-qing&rft.aulast=Guo&rft.aufirst=Zai-qing&rft.date=2015-04-01&rft.volume=27&rft.issue=4&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Microecology&rft.issn=1005376X&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Intestinal microflora; Data processing; Intestine; Enterobacteriaceae ER - TY - JOUR T1 - High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures AN - 1680448256; PQ0001483290 AB - Inhalation anthrax has a rapid progression and high fatality rate. Pathology and death from inhalation of Bacillus anthracis spores are attributed to the actions of secreted protein toxins. Protective antigen (PA) binds and imports the catalytic component lethal factor (LF), a zinc endoprotease, and edema factor (EF), an adenylyl cyclase, into susceptible cells. PA-LF is termed lethal toxin (LTx) and PA-EF, edema toxin. As the universal transporter for both toxins, PA is an important target for vaccination and immunotherapeutic intervention. However, its quantification has been limited to methods of relatively low analytic sensitivity. Quantification of LTx may be more clinically relevant than LF or PA alone because LTx is the toxic form that acts on cells. A method was developed for LTx-specific quantification in plasma using anti-PA IgG magnetic immunoprecipitation of PA and quantification of LF activity that co-purified with PA. The method was fast (<4 h total time to detection), sensitive at 0.033 ng/mL LTx in plasma for the fast analysis (0.0075 ng/mL LTx in plasma for an 18 h reaction), precise (6.3-9.9 % coefficient of variation), and accurate (0.1-12.7 %error; n greater than or equal to 25). Diagnostic sensitivity was 100 % (n=27 animal/clinical cases). Diagnostic specificity was 100 % (n=141). LTx was detected post-antibiotic treatment in 6/6 treated rhesus macaques and 3/3 clinical cases of inhalation anthrax and as long as 8 days post-treatment. Over the course of infection in two rhesus macaques, LTx was first detected at 0.101 and 0.237 ng/mL at 36 h post-exposure and increased to 1147 and 12,107 ng/mL in late-stage anthrax. This demonstrated the importance of LTx as a diagnostic and therapeutic target. This method provides a sensitive, accurate tool for anthrax toxin detection and evaluation of PA-directed therapeutics. [Figure not available: see fulltext.] JF - Analytical and Bioanalytical Chemistry AU - Boyer, Anne E AU - Gallegos-Candela, Maribel AU - Quinn, Conrad P AU - Woolfitt, Adrian R AU - Brumlow, Judith O AU - Isbell, Katherine AU - Hoffmaster, Alex R AU - Lins, Renato C AU - Barr, John R AD - Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA, jbarr@cdc.gov PY - 2015 SP - 2847 EP - 2858 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 10 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; Toxicology Abstracts KW - Inhalation KW - Import KW - Pathology KW - Lethal factor KW - Edema KW - Bacillus anthracis KW - Infection KW - Evaluation KW - Bacteria (bacillaceae) (bacillus) KW - Zinc KW - Anthrax KW - Macaca mulatta KW - Adenylate cyclase KW - Anthrax lethal toxin KW - protective antigen KW - Immunoprecipitation KW - Vaccination KW - Toxins KW - Immunoglobulin G KW - Proteins KW - Spores KW - AQ 00001:Water Resources and Supplies KW - X 24390:Radioactive Materials KW - SW 5080:Evaluation, processing and publication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680448256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=High-sensitivity+MALDI-TOF+MS+quantification+of+anthrax+lethal+toxin+for+diagnostics+and+evaluation+of+medical+countermeasures&rft.au=Boyer%2C+Anne+E%3BGallegos-Candela%2C+Maribel%3BQuinn%2C+Conrad+P%3BWoolfitt%2C+Adrian+R%3BBrumlow%2C+Judith+O%3BIsbell%2C+Katherine%3BHoffmaster%2C+Alex+R%3BLins%2C+Renato+C%3BBarr%2C+John+R&rft.aulast=Boyer&rft.aufirst=Anne&rft.date=2015-04-01&rft.volume=407&rft.issue=10&rft.spage=2847&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-8509-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 36 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Inhalation; Anthrax lethal toxin; Lethal factor; protective antigen; Immunoprecipitation; Edema; Infection; Vaccination; Toxins; Zinc; Immunoglobulin G; Anthrax; Spores; Adenylate cyclase; Evaluation; Import; Pathology; Bacteria (bacillaceae) (bacillus); Proteins; Macaca mulatta; Bacillus anthracis DO - http://dx.doi.org/10.1007/s00216-015-8509-5 ER - TY - JOUR T1 - Structure and Receptor Binding Preferences of Recombinant Hemagglutinins from Avian and Human H6 and H10 Influenza A Virus Subtypes AN - 1676354592; PQ0001421939 AB - During 2013, three new avian influenza A virus subtypes, A(H7N9), A(H6N1), and A(H10N8), resulted in human infections. While the A(H7N9) virus resulted in a significant epidemic in China across 19 provinces and municipalities, both A(H6N1) and A(H10N8) viruses resulted in only a few human infections. This study focuses on the major surface glycoprotein hemagglutinins from both of these novel human viruses. The detailed structural and glycan microarray analyses presented here highlight the idea that both A(H6N1) and A(H10N8) virus hemagglutinins retain a strong avian receptor binding preference and thus currently pose a low risk for sustained human infections. IMPORTANCE Human infections with zoonotic influenza virus subtypes continue to be a great public health concern. We report detailed structural analysis and glycan microarray data for recombinant hemagglutinins from A(H6N1) and A(H10N8) viruses, isolated from human infections in 2013, and compare them with hemagglutinins of avian origin. This is the first structural report of an H6 hemagglutinin, and our results should further the understanding of these viruses and provide useful information to aid in the continuous surveillance of these zoonotic influenza viruses. JF - Journal of Virology AU - Yang, Hua AU - Carney, Paul J AU - Chang, Jessie C AU - Villanueva, Julie M AU - Stevens, James Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 4612 EP - 4623 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 8 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Epidemics KW - Hemagglutinins KW - Viruses KW - Structural analysis KW - Infection KW - Polysaccharides KW - Public health KW - Influenza KW - Fowl plague KW - Influenza A virus KW - Risk factors KW - China, People's Rep. KW - Glycoproteins KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676354592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Structure+and+Receptor+Binding+Preferences+of+Recombinant+Hemagglutinins+from+Avian+and+Human+H6+and+H10+Influenza+A+Virus+Subtypes&rft.au=Yang%2C+Hua%3BCarney%2C+Paul+J%3BChang%2C+Jessie+C%3BVillanueva%2C+Julie+M%3BStevens%2C+James&rft.aulast=Yang&rft.aufirst=Hua&rft.date=2015-04-01&rft.volume=89&rft.issue=8&rft.spage=4612&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03456-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 71 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Fowl plague; Epidemics; Data processing; Risk factors; Hemagglutinins; Glycoproteins; Polysaccharides; Infection; Public health; Influenza; Structural analysis; Viruses; Influenza A virus; China, People's Rep. DO - http://dx.doi.org/10.1128/JVI.03456-14 ER - TY - JOUR T1 - In Vitro Assessment of Dual Drug Combinations To Inhibit Growth of Neisseria gonorrhoeae AN - 1676353534; PQ0001421523 AB - The development of resistance to first-line antimicrobial therapies has led to recommendations for combination therapies for the treatment of gonorrhea infection. Recent studies have shown the success of combination therapies in treating patients, but few have reported on the in vitro activities of these drug combinations. An in vitro assessment of azithromycin in combination with gentamicin demonstrated inhibition of growth and suggests that clinical trials may be warranted to assess the utility of this combination in treating gonorrhea infections. JF - Antimicrobial Agents & Chemotherapy AU - Pettus, Kevin AU - Sharpe, Samera AU - Papp, John R Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 2443 EP - 2445 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 4 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Gentamicin KW - Azithromycin KW - Gonorrhea KW - Infection KW - Drug screening KW - Clinical trials KW - Neisseria gonorrhoeae KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676353534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Assessment+of+Dual+Drug+Combinations+To+Inhibit+Growth+of+Neisseria+gonorrhoeae&rft.au=Pettus%2C+Kevin%3BSharpe%2C+Samera%3BPapp%2C+John+R&rft.aulast=Pettus&rft.aufirst=Kevin&rft.date=2015-04-01&rft.volume=59&rft.issue=4&rft.spage=2443&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04127-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 8 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Gentamicin; Azithromycin; Gonorrhea; Drug screening; Infection; Clinical trials; Antimicrobial agents; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.04127-14 ER - TY - JOUR T1 - Variola Virus-Specific Diagnostic Assays: Characterization, Sensitivity, and Specificity AN - 1676352238; PQ0001421846 AB - A public health response relies upon rapid and reliable confirmation of disease by diagnostic assays. Here, we detail the design and validation of two variola virus-specific real-time PCR assays, since previous assays cross-reacted with newly identified cowpox viruses. The assay specificity must continually be reassessed as other closely related viruses are identified. JF - Journal of Clinical Microbiology AU - Kondas, Ashley V AU - Olson, Victoria A AU - Li, Yu AU - Abel, Jason AU - Laker, Miriam AU - Rose, Laura AU - Wilkins, Kimberly AU - Turner, Jonathan AU - Kline, Richard AU - Damon, Inger K Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 1406 EP - 1410 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 4 SN - 0095-1137, 0095-1137 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Smallpox KW - Sensitivity KW - Viruses KW - Variola KW - Assays KW - Polymerase chain reaction KW - Cowpox KW - Public health KW - H 12000:Epidemiology and Public Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676352238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Variola+Virus-Specific+Diagnostic+Assays%3A+Characterization%2C+Sensitivity%2C+and+Specificity&rft.au=Kondas%2C+Ashley+V%3BOlson%2C+Victoria+A%3BLi%2C+Yu%3BAbel%2C+Jason%3BLaker%2C+Miriam%3BRose%2C+Laura%3BWilkins%2C+Kimberly%3BTurner%2C+Jonathan%3BKline%2C+Richard%3BDamon%2C+Inger+K&rft.aulast=Kondas&rft.aufirst=Ashley&rft.date=2015-04-01&rft.volume=53&rft.issue=4&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.03613-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 13 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Smallpox; Polymerase chain reaction; Cowpox; Public health; Sensitivity; Viruses; Assays; Variola DO - http://dx.doi.org/10.1128/JCM.03613-14 ER - TY - JOUR T1 - Application of a Seven-Target Pyrosequencing Assay To Improve the Detection of Neuraminidase Inhibitor-Resistant Influenza A(H3N2) Viruses AN - 1676347835; PQ0001421581 AB - National U.S. influenza antiviral surveillance incorporates data generated by neuraminidase (NA) inhibition (NI) testing of isolates supplemented with NA sequence analysis and pyrosequencing analysis of clinical specimens. A lack of established correlates for clinically relevant resistance to NA inhibitors (NAIs) hinders interpretation of NI assay data. Nonetheless, A(H3N2) viruses are commonly monitored for moderately or highly reduced inhibition in the NI assay and/or for the presence of NA markers E119V, R292K, and N294S. In 2012 to 2013, three drug-resistant A(H3N2) viruses were detected by NI assay among isolates (n = 1,424); all showed highly reduced inhibition by oseltamivir and had E119V. In addition, one R292K variant was detected among clinical samples (n = 1,024) by a 3-target pyrosequencing assay. Overall, the frequency of NAI resistance was low (0.16% [4 of 2,448]). To screen for additional NA markers previously identified in viruses from NAI-treated patients, the pyrosequencing assay was modified to include Q136K, I222V, and deletions encompassing residues 245 to 248 (del245-248) and residues 247 to 250 (del247-250). The 7-target pyrosequencing assay detected NA variants carrying E119V, Q136, and del245-248 in an isolate from an oseltamivir-treated patient. Next, this assay was applied to clinical specimens collected from hospitalized patients and submitted for NI testing but failed cell culture propagation. Of the 27 clinical specimens tested, 4 (15%) contained NA changes: R292K (n = 2), E119V (n = 1), and del247-250 (n = 1). Recombinant NAs with del247-250 or del245-248 conferred highly reduced inhibition by oseltamivir, reduced inhibition by zanamivir, and normal inhibition by peramivir and laninamivir. Our results demonstrated the benefits of the 7-target pyrosequencing assay in conducting A(H3N2) antiviral surveillance and testing for clinical care. JF - Antimicrobial Agents & Chemotherapy AU - Tamura, Daisuke AU - Okomo-Adhiambo, Margaret AU - Mishin, Vasiliy P AU - Guo, Zhu AU - Xu, Xiyan AU - Villanueva, Julie AU - Fry, Alicia M AU - Stevens, James AU - Gubareva, Larisa V AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, lqg3@cdc.gov. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 2374 EP - 2379 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 4 SN - 0066-4804, 0066-4804 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - Residues KW - Chemotherapy KW - Drug resistance KW - Viruses KW - Assays KW - Cell culture KW - Zanamivir KW - Antimicrobial agents KW - Oseltamivir KW - Influenza KW - Exo- alpha -sialidase KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - H 13000:Medical Safety KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676347835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Application+of+a+Seven-Target+Pyrosequencing+Assay+To+Improve+the+Detection+of+Neuraminidase+Inhibitor-Resistant+Influenza+A%28H3N2%29+Viruses&rft.au=Tamura%2C+Daisuke%3BOkomo-Adhiambo%2C+Margaret%3BMishin%2C+Vasiliy+P%3BGuo%2C+Zhu%3BXu%2C+Xiyan%3BVillanueva%2C+Julie%3BFry%2C+Alicia+M%3BStevens%2C+James%3BGubareva%2C+Larisa+V&rft.aulast=Tamura&rft.aufirst=Daisuke&rft.date=2015-04-01&rft.volume=59&rft.issue=4&rft.spage=2374&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04939-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 30 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Influenza; Data processing; Drug resistance; Cell culture; Exo- alpha -sialidase; Zanamivir; Oseltamivir; Residues; Chemotherapy; Viruses; Assays; Hospitals; Antimicrobial agents DO - http://dx.doi.org/10.1128/AAC.04939-14 ER - TY - JOUR T1 - A(H7N9) Virus Results in Early Induction of Proinflammatory Cytokine Responses in both Human Lung Epithelial and Endothelial Cells and Shows Increased Human Adaptation Compared with Avian H5N1 Virus AN - 1676346024; PQ0001421927 AB - Similar to H5N1 viruses, A(H7N9) influenza viruses have been associated with severe respiratory disease and fatal outcomes in humans. While high viral load, hypercytokinemia, and pulmonary endothelial cell involvement are known to be hallmarks of H5N1 virus infection, the pathogenic mechanism of the A(H7N9) virus in humans is largely unknown. In this study, we assessed the ability of A(H7N9) virus to infect, replicate, and elicit innate immune responses in both human bronchial epithelial cells and pulmonary microvascular endothelial cells, compared with the abilities of seasonal H3N2, avian H7N9, and H5N1 viruses. In epithelial cells, A(H7N9) virus replicated efficiently but did not elicit robust induction of cytokines like that observed for H5N1 virus. In pulmonary endothelial cells, A(H7N9) virus efficiently initiated infection; however, no released infectious virus was detected. The magnitudes of induction of host cytokine responses were comparable between A(H7N9) and H5N1 virus infection. Additionally, we utilized differentiated human primary bronchial and tracheal epithelial cells to investigate cellular tropism using transmission electron microscopy and the impact of temperature on virus replication. Interestingly, A(H7N9) virus budded from the surfaces of both ciliated and mucin-secretory cells. Furthermore, A(H7N9) virus replicated to a significantly higher titer at 37 degree C than at 33 degree C, with improved replication capacity at 33 degree C compared to that of H5N1 virus. These findings suggest that a high viral load from lung epithelial cells coupled with induction of host responses in endothelial cells may contribute to the severe pulmonary disease observed following H7N9 virus infection. Improved adaptation of A(H7N9) virus to human upper airway poses an important threat to public health. IMPORTANCE A(H7N9) influenza viruses have caused over 450 documented human infections with a 30% fatality rate since early 2013. However, these novel viruses lack many molecular determinants previously identified with mammalian pathogenicity, necessitating a closer examination of how these viruses elicit host responses which could be detrimental. This study provides greater insight into the interaction of this virus with host lung epithelial cells and endothelial cells, which results in high viral load, epithelial cell death, and elevated immune response in the lungs, revealing the mechanism of pathogenesis and disease development among A(H7N9)-infected patients. In particular, we characterized the involvement of pulmonary endothelial cells, a cell type in the human lung accessible to influenza virus following damage of the epithelial monolayer, and its potential role in the development of severe pneumonia caused by A(H7N9) infection in humans. JF - Journal of Virology AU - Zeng, Hui AU - Belser, Jessica A AU - Goldsmith, Cynthia S AU - Gustin, Kortney M AU - Veguilla, Vic AU - Katz, Jacqueline M AU - Tumpey, Terrence M AD - Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, tft9@cdc.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 4655 EP - 4667 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 8 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Epithelial cells KW - Transmission electron microscopy KW - Viruses KW - Respiratory diseases KW - Infection KW - Public health KW - Influenza KW - Endothelial cells KW - Sulfur dioxide KW - Pathogenicity KW - Cytokines KW - Seasonal variations KW - Respiratory tract KW - Temperature effects KW - Mortality KW - Microvasculature KW - Adaptations KW - Replication KW - Tropism KW - Temperature KW - Lung diseases KW - Inflammation KW - Adaptability KW - Influenza virus KW - Lung KW - Microscopy KW - Immune response KW - Pneumonia KW - V 22350:Immunology KW - H 1000:Occupational Safety and Health KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676346024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A%28H7N9%29+Virus+Results+in+Early+Induction+of+Proinflammatory+Cytokine+Responses+in+both+Human+Lung+Epithelial+and+Endothelial+Cells+and+Shows+Increased+Human+Adaptation+Compared+with+Avian+H5N1+Virus&rft.au=Zeng%2C+Hui%3BBelser%2C+Jessica+A%3BGoldsmith%2C+Cynthia+S%3BGustin%2C+Kortney+M%3BVeguilla%2C+Vic%3BKatz%2C+Jacqueline+M%3BTumpey%2C+Terrence+M&rft.aulast=Zeng&rft.aufirst=Hui&rft.date=2015-04-01&rft.volume=89&rft.issue=8&rft.spage=4655&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03095-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 52 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Temperature effects; Microvasculature; Epithelial cells; Adaptations; Replication; Transmission electron microscopy; Tropism; Lung diseases; Infection; Inflammation; Public health; Endothelial cells; Influenza; Pathogenicity; Lung; Cytokines; Immune response; Pneumonia; Respiratory tract; Mortality; Viruses; Temperature; Respiratory diseases; Adaptability; Sulfur dioxide; Microscopy; Seasonal variations; Influenza virus DO - http://dx.doi.org/10.1128/JVI.03095-14 ER - TY - JOUR T1 - HIV-1 vaccines based on replication-competent Tiantan vaccinia protected Chinese rhesus macaques from simian HIV infection AN - 1808629405; PQ0003241713 AB - Objective: To assess the efficacy of HIV vaccines constructed from replication-competent Tiantan vaccinia virus (rTV) alone or combined with DNA in protecting Chinese rhesus macaques from homologous Simian/Human Immunodeficiency Virus (SHIV)-CN97001 challenge. Methods: The nef, gag, pol, and gp140 genes from strain CRF07_BC HIV-1 CN54 were selected to construct an HIV vaccine using the rTV or rTV/DNA vaccine. After vaccination, the vaccine and control groups were intravenously challenged with SHIV-CN97001 (32 MID sub(50)). HIV-specific antibodies and neutralizing antibodies, gp70 V1V2 binding antibodies, and cytotoxic T-lymphocyte responses were measured prospectively after vaccination with an ELISA, a virus infectivity assay in TZM-bl cells, and ELISPOT assays, respectively. Viral RNA was quantified after challenge with real-time reverse transcriptase-PCR (RT-PCR), and protection efficacy was determined with an analysis of CD8 super(+) lymphocyte depletion in vivo. Results: Both rTV and DNA/rTV vaccine groups developed strong cellular and humoral responses against HIV-1 CN54 antigens, including Gag and Env, and also developed significant and persistent anti-Env antibodies and neutralizing antibodies after immunization. Both the rTV and DNA/rTV groups were significantly protected against SHIV-CN97001 or displayed lower viremia than the controls. After CD8 super(+) lymphocyte depletion, no viremia was detectable in the vaccinated monkeys, but rebounded rapidly in the control animals. Protection against infection correlated with vaccine-elicited neutralizing antibodies specific for homologous HIV-1 viruses. Conclusion: An rTV-based HIV-1 vaccine, with or without a DNA primer, provided protection from SHIV challenge in a macaque model. Replication-competent Tiantan vaccinia is a promising vector and should enable advances in HIV-1 vaccine development JF - AIDS AU - Liu, Qiang AU - Li, Yue AU - Luo, Zhenwu AU - Yang, Guibo AU - Liu, Yong AU - Liu, Ying AU - Sun, Maosheng AU - Dai, Jiejie AU - Li, Qihan AU - Qin, Chuan AU - Shao, Yiming AD - State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, yshao08@gmail.com Y1 - 2015/03/27/ PY - 2015 DA - 2015 Mar 27 SP - 649 EP - 658 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 29 IS - 6 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - HIV-1 KW - replication Tiantan vaccinia KW - simian HIV KW - vaccine KW - Acquired immune deficiency syndrome KW - Viruses KW - Simian/human immunodeficiency virus KW - Lymphocytes KW - Infection KW - DNA vaccines KW - Combined vaccines KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Polymerase chain reaction KW - Macaca mulatta KW - Enzyme-linked immunosorbent assay KW - Vaccinia KW - CD8 antigen KW - Nef protein KW - Immunization KW - Gag protein KW - Cytotoxicity KW - Infectivity KW - Antibodies KW - Vaccinia virus KW - RNA KW - Human immunodeficiency virus KW - DNA KW - Primers KW - Vaccines KW - Viremia KW - Corticotropin-releasing hormone KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808629405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=HIV-1+vaccines+based+on+replication-competent+Tiantan+vaccinia+protected+Chinese+rhesus+macaques+from+simian+HIV+infection&rft.au=Liu%2C+Qiang%3BLi%2C+Yue%3BLuo%2C+Zhenwu%3BYang%2C+Guibo%3BLiu%2C+Yong%3BLiu%2C+Ying%3BSun%2C+Maosheng%3BDai%2C+Jiejie%3BLi%2C+Qihan%3BQin%2C+Chuan%3BShao%2C+Yiming&rft.aulast=Liu&rft.aufirst=Qiang&rft.date=2015-03-27&rft.volume=29&rft.issue=6&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000595 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Vaccinia; CD8 antigen; Nef protein; Infection; Gag protein; Antibodies; Infectivity; Cytotoxicity; RNA; DNA vaccines; Combined vaccines; Lymphocytes T; Polymerase chain reaction; Primers; Viremia; Corticotropin-releasing hormone; Acquired immune deficiency syndrome; Human immunodeficiency virus; Viruses; DNA; Lymphocytes; Vaccines; Immunization; Vaccinia virus; Human immunodeficiency virus 1; Simian/human immunodeficiency virus; Macaca mulatta DO - http://dx.doi.org/10.1097/QAD.0000000000000595 ER - TY - JOUR T1 - Computational framework for next-generation sequencing of heterogeneous viral populations using combinatorial pooling AN - 1701474626; PQ0001733169 AB - Motivation: Next-generation sequencing (NGS) allows for analyzing a large number of viral sequences from infected patients, providing an opportunity to implement large-scale molecular surveillance of viral diseases. However, despite improvements in technology, traditional protocols for NGS of large numbers of samples are still highly cost and labor intensive. One of the possible cost-effective alternatives is combinatorial pooling. Although a number of pooling strategies for consensus sequencing of DNA samples and detection of SNPs have been proposed, these strategies cannot be applied to sequencing of highly heterogeneous viral populations.Results: We developed a cost-effective and reliable protocol for sequencing of viral samples, that combines NGS using barcoding and combinatorial pooling and a computational framework including algorithms for optimal virus-specific pools design and deconvolution of individual samples from sequenced pools. Evaluation of the framework on experimental and simulated data for hepatitis C virus showed that it substantially reduces the sequencing costs and allows deconvolution of viral populations with a high accuracy.Availability and implementation: The source code and experimental data sets are available at http://alan.cs.gsu.edu/NGS/?q=content/pooling Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Skums, Pavel AU - Artyomenko, Alexander AU - Glebova, Olga AU - Ramachandran, Sumathi AU - Mandoiu, Ion AU - Campo, David S AU - Dimitrova, Zoya AU - Zelikovsky, Alex AU - Khudyakov, Yury AD - *To whom correspondence should be addressed., kki8@cdc.gov Y1 - 2015/03/01/ PY - 2015 DA - 2015 Mar 01 SP - 682 EP - 690 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 31 IS - 5 SN - 1367-4803, 1367-4803 KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - DNA sequencing KW - Data processing KW - Hepatitis C virus KW - Single-nucleotide polymorphism KW - Nucleotide sequence KW - Algorithms KW - DNA KW - Bioinformatics KW - Computer applications KW - Internet KW - N 14810:Methods KW - V 22400:Human Diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701474626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Computational+framework+for+next-generation+sequencing+of+heterogeneous+viral+populations+using+combinatorial+pooling&rft.au=Skums%2C+Pavel%3BArtyomenko%2C+Alexander%3BGlebova%2C+Olga%3BRamachandran%2C+Sumathi%3BMandoiu%2C+Ion%3BCampo%2C+David+S%3BDimitrova%2C+Zoya%3BZelikovsky%2C+Alex%3BKhudyakov%2C+Yury&rft.aulast=Skums&rft.aufirst=Pavel&rft.date=2015-03-01&rft.volume=31&rft.issue=5&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/10.1093%2Fbioinformatics%2Fbtu726 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - DNA sequencing; Data processing; Single-nucleotide polymorphism; Nucleotide sequence; DNA; Algorithms; Bioinformatics; Computer applications; Internet; Hepatitis C virus DO - http://dx.doi.org/10.1093/bioinformatics/btu726 ER - TY - JOUR T1 - Demographic Trends of Sick Leave Absenteeism Among Civil Service Employees at a Federal Agency From 2004 to 2012 AN - 1680447849; PQ0001516813 AB - Objective: To investigate the associations between demographic variables and sick leave use. Methods: We analyzed sick leave use among civil servants at a federal agency (FA) from 2004 to 2012 by demographic and FA-specific variables. We used a mixed methods approach and type III analysis to build a descriptive model of sick leave proportions and demographic variables. Results: Sick absenteeism usage varied significantly (variation of greater than one sick day per year) by sex, Emergency Operations Center response tier, length of service at the FA, age, and general schedule pay grade level. Our final descriptive model contained age, sex, response tier and an interaction term between age and sex. Conclusions: Future studies should examine these associations on smaller time scales, perhaps breaking the data down by month or day of the week. JF - Journal of Occupational and Environmental Medicine AU - Gajewski, Kim AU - Burris, Dara AU - Spears, D Ross AU - Sullivan, Kevin AU - Oyinloye, Oluremi AU - McNeil, Carrie AU - Meechan, Paul AU - Warnock, Eli AU - Trapp, Jonathan AU - Decker, K C AU - Chapman, Sandy AD - Environment, Safety, and Health Compliance Office, ava3@cdc.gov PY - 2015 SP - 277 EP - 283 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 3 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Demography KW - Age KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680447849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Demographic+Trends+of+Sick+Leave+Absenteeism+Among+Civil+Service+Employees+at+a+Federal+Agency+From+2004+to+2012&rft.au=Gajewski%2C+Kim%3BBurris%2C+Dara%3BSpears%2C+D+Ross%3BSullivan%2C+Kevin%3BOyinloye%2C+Oluremi%3BMcNeil%2C+Carrie%3BMeechan%2C+Paul%3BWarnock%2C+Eli%3BTrapp%2C+Jonathan%3BDecker%2C+K+C%3BChapman%2C+Sandy&rft.aulast=Gajewski&rft.aufirst=Kim&rft.date=2015-03-01&rft.volume=57&rft.issue=3&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000347 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Demography; Age DO - http://dx.doi.org/10.1097/JOM.0000000000000347 ER - TY - JOUR T1 - NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection AN - 1668259115; PQ0001249016 AB - The NLR protein, NLRC5 is an important regulator of MHC class I gene expression, however, the role of NLRC5 in other innate immune responses is less well defined. In the present study, we report that NLRC5 binds RIG-I and that this interaction is critical for robust antiviral responses against influenza virus. Overexpression of NLRC5 in the human lung epithelial cell line, A549, and normal human bronchial epithelial cells resulted in impaired replication of influenza virus A/Puerto Rico/8/34 virus (PR8) and enhanced IFN- beta expression. Influenza virus leads to induction of IFN- beta that drives RIG-I and NLRC5 expression in host cells. Our results suggest that NLRC5 extends and stabilizes influenza virus induced RIG-I expression and delays expression of the viral inhibitor protein NS1. We show that NS1 binds to NLRC5 to suppress its function. Interaction domain mapping revealed that NLRC5 interacts with RIG-I via its N-terminal death domain and that NLRC5 enhanced antiviral activity in an leucine-rich repeat domain independent manner. Taken together, our findings identify a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. JF - European Journal of Immunology AU - Ranjan, Priya AU - Singh, Neetu AU - Kumar, Amrita AU - Neerincx, Andreas AU - Kremmer, Elisabeth AU - Cao, Weiping AU - Davis, William G AU - Katz, Jacqueline M AU - Gangappa, Shivaprakash AU - Lin, Rongtuan AU - Kufer, Thomas A AU - Sambhara, Suryaprakash AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 758 EP - 772 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 45 IS - 3 SN - 0014-2980, 0014-2980 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - beta -Interferon KW - Mortality KW - Epithelial cells KW - Replication KW - Immunology KW - Major histocompatibility complex KW - Infection KW - Antiviral activity KW - Influenza KW - Nlr protein KW - Influenza virus KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Lung KW - Influenza A virus KW - Proteins KW - Mapping KW - Immune response KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668259115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=NLRC5+interacts+with+RIG-I+to+induce+a+robust+antiviral+response+against+influenza+virus+infection&rft.au=Ranjan%2C+Priya%3BSingh%2C+Neetu%3BKumar%2C+Amrita%3BNeerincx%2C+Andreas%3BKremmer%2C+Elisabeth%3BCao%2C+Weiping%3BDavis%2C+William+G%3BKatz%2C+Jacqueline+M%3BGangappa%2C+Shivaprakash%3BLin%2C+Rongtuan%3BKufer%2C+Thomas+A%3BSambhara%2C+Suryaprakash&rft.aulast=Ranjan&rft.aufirst=Priya&rft.date=2015-03-01&rft.volume=45&rft.issue=3&rft.spage=758&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Influenza; Nlr protein; Epithelial cells; Lung; Replication; Major histocompatibility complex; Immune response; Antiviral activity; Infection; Mortality; Immunology; Proteins; Mapping; Influenza virus; Influenza A virus; ASW, Caribbean Sea, Greater Antilles, Puerto Rico DO - http://dx.doi.org/10.1002/eji.201344412 ER - TY - JOUR T1 - Contribution of the BacT/Alert MB Mycobacterium Bottle to Bloodstream Infection Surveillance in Thailand: Added Yield for Burkholderia pseudomallei AN - 1668252057; PQ0001232693 AB - Community-acquired bloodstream infections cause substantial morbidity and mortality worldwide, but microbiology capacity and surveillance limitations have challenged good descriptions of pathogen distribution in many regions, including Southeast Asia. Active surveillance for bloodstream infections has been conducted in two rural Thailand provinces for >7 years. Blood specimens were divided into two culture bottles, one optimized for aerobic growth (F bottle) and a second for enhanced growth of mycobacteria (MB bottle), and processed with the BactT/Alert 3D system. Because the routine use of MB culture bottles is resource intensive (expensive and requires prolonged incubation), we assessed the added yield of MB bottles by comparing the proportion of pathogens detected by MB versus that by F bottles from 2005 to 2012. Of 63,066 blood cultures, 7,296 (12%) were positive for at least one pathogen; the most common pathogens were Escherichia coli (28%), Burkholderia pseudomallei (11%), Klebsiella pneumoniae (9%), and Staphylococcus aureus (6%). Two bottles improved the yield overall, but the added yield attributable to the MB bottles was limited to a few pathogens. In addition to the detection of mycobacteria and some fungi, MB bottles improved the detection of B. pseudomallei (27% [MB] versus 8% [F]; P < 0.0001), with added benefit if therapy was initiated prior to the blood culture. The targeted use of MB bottles is warranted for patients at risk for mycobacterial and fungal infections and for infection with B. pseudomallei, a common cause of septicemia in Thailand. JF - Journal of Clinical Microbiology AU - Jorakate, Possawat AU - Higdon, Melissa AU - Kaewpan, Anek AU - Makprasert, Sirirat AU - Yuenprakhon, Somkhit AU - Tawisaid, Kittisak AU - Dejsirilert, Surang AU - Whistler, Toni AU - Baggett, Henry C AD - Global Disease Detection, Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention (CDC) Collaboration, Nonthaburi, Thailand, hqg0@cdc.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 910 EP - 914 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 3 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Burkholderia pseudomallei KW - Blood culture KW - Mortality KW - Septicemia KW - Mycobacterium KW - Fungi KW - Pathogens KW - Infection KW - Morbidity KW - Escherichia coli KW - Staphylococcus aureus KW - Klebsiella pneumoniae KW - J 02400:Human Diseases KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668252057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Contribution+of+the+BacT%2FAlert+MB+Mycobacterium+Bottle+to+Bloodstream+Infection+Surveillance+in+Thailand%3A+Added+Yield+for+Burkholderia+pseudomallei&rft.au=Jorakate%2C+Possawat%3BHigdon%2C+Melissa%3BKaewpan%2C+Anek%3BMakprasert%2C+Sirirat%3BYuenprakhon%2C+Somkhit%3BTawisaid%2C+Kittisak%3BDejsirilert%2C+Surang%3BWhistler%2C+Toni%3BBaggett%2C+Henry+C&rft.aulast=Jorakate&rft.aufirst=Possawat&rft.date=2015-03-01&rft.volume=53&rft.issue=3&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02008-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 20 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Blood culture; Mortality; Septicemia; Fungi; Pathogens; Infection; Morbidity; Burkholderia pseudomallei; Mycobacterium; Escherichia coli; Staphylococcus aureus; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/JCM.02008-14 ER - TY - JOUR T1 - Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance AN - 1668250828; PQ0001205004 AB - Background In 2000, seven-valent pneumococcal conjugate vaccine (PCV7) was introduced in the USA and resulted in dramatic reductions in invasive pneumococcal disease (IPD) and moderate increases in non-PCV7 type IPD. In 2010, PCV13 replaced PCV7 in the US immunisation schedule. We aimed to assess the effect of use of PCV13 in children on IPD in children and adults in the USA. Methods We used laboratory-based and population-based data on incidence of IPD from the Active Bacterial Core surveillance (part of the Centers for Disease Control and Prevention's Emerging Infections Program) in a time-series model to compare rates of IPD before and after the introduction of PCV13. Cases of IPD between July 1, 2004, and June 30, 2013, were classified as being caused by the PCV13 serotypes against which PCV7 has no effect (PCV13 minus PCV7). In a time-series model, we used an expected outcomes approach to compare the reported incidence of IPD to that which would have been expected if PCV13 had not replaced PCV7. Findings Compared with incidence expected among children younger than 5 years if PCV7 alone had been continued, incidence of IPD overall declined by 64% (95% interval estimate [95% IE] 59-68) and IPD caused by PCV13 minus PCV7 serotypes declined by 93% (91-94), by July, 2012, to June, 2013. Among adults, incidence of IPD overall also declined by 12-32% and IPD caused by PCV13 minus PCV7 type IPD declined by 58-72%, depending on age. We estimated that over 30000 cases of IPD and 3000 deaths were averted in the first 3 years after the introduction of PCV13. Interpretation PCV13 reduced IPD across all age groups when used routinely in children in the USA. These findings provide reassurance that, similar to PCV7, PCVs with additional serotypes can also prevent transmission to unvaccinated populations. Funding Centers for Disease Control and Prevention. JF - Lancet Infectious Diseases AU - Moore, Matthew R AU - Link-Gelles, Ruth AU - Schaffner, William AU - Lynfield, Ruth AU - Lexau, Catherine AU - Bennett, Nancy M AU - Petit, Susan AU - Zansky, Shelley M AU - Harrison, Lee H AU - Reingold, Arthur AU - Miller, Lisa AU - Scherzinger, Karen AU - Thomas, Ann AU - Farley, Monica M AU - Zell, Elizabeth R AU - Taylor, Thomas H, Jr AU - Pondo, Tracy AU - Rodgers, Loren AU - McGee, Lesley AU - Beall, Bernard AU - Jorgensen, James H AU - Whitney, Cynthia G AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 301 EP - 309 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 15 IS - 3 SN - 1473-3099, 1473-3099 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus pneumoniae KW - Age KW - Serotypes KW - Data processing KW - Disease control KW - Vaccines KW - Children KW - Infection KW - Immunization KW - Models KW - Disease transmission KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668250828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+Infectious+Diseases&rft.atitle=Effect+of+use+of+13-valent+pneumococcal+conjugate+vaccine+in+children+on+invasive+pneumococcal+disease+in+children+and+adults+in+the+USA%3A+analysis+of+multisite%2C+population-based+surveillance&rft.au=Moore%2C+Matthew+R%3BLink-Gelles%2C+Ruth%3BSchaffner%2C+William%3BLynfield%2C+Ruth%3BLexau%2C+Catherine%3BBennett%2C+Nancy+M%3BPetit%2C+Susan%3BZansky%2C+Shelley+M%3BHarrison%2C+Lee+H%3BReingold%2C+Arthur%3BMiller%2C+Lisa%3BScherzinger%2C+Karen%3BThomas%2C+Ann%3BFarley%2C+Monica+M%3BZell%2C+Elizabeth+R%3BTaylor%2C+Thomas+H%2C+Jr%3BPondo%2C+Tracy%3BRodgers%2C+Loren%3BMcGee%2C+Lesley%3BBeall%2C+Bernard%3BJorgensen%2C+James+H%3BWhitney%2C+Cynthia+G&rft.aulast=Moore&rft.aufirst=Matthew&rft.date=2015-03-01&rft.volume=15&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Lancet+Infectious+Diseases&rft.issn=14733099&rft_id=info:doi/10.1016%2FS1473-3099%2814%2971081-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 24 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Serotypes; Disease control; Vaccines; Infection; Children; Immunization; Disease transmission; Models; Streptococcus pneumoniae DO - http://dx.doi.org/10.1016/S1473-3099(14)71081-3 ER - TY - JOUR T1 - Methods for surveillance of fetal alcohol syndrome: The Fetal Alcohol Syndrome Surveillance Network II (FASSNetII) - Arizona, Colorado, New York, 2009 - 2014. AN - 1666726036; 25761572 AB - Surveillance of fetal alcohol syndrome (FAS) is important for monitoring the effects of prenatal alcohol exposure and describing the public health burden of this preventable disorder. Building on the infrastructure of the Fetal Alcohol Syndrome Surveillance Network (FASSNet, 1997-2002), in 2009 the Centers for Disease Control and Prevention awarded 5-year cooperative agreements to three states, Arizona, Colorado, and New York, to conduct population-based surveillance of FAS. The Fetal Alcohol Syndrome Surveillance Network II (FASSNetII, 2009-2014) developed a surveillance case definition based on three clinical criteria: characteristic facial features, central nervous system abnormalities, and growth deficiency. FASSNetII modified the FASSNet methods in three important ways: (1) estimation of a period prevalence rather than birth prevalence; (2) surveillance of FAS among school-age children (ages 7-9 years) to better document the central nervous system abnormalities that are not apparent at birth or during infancy; and (3) implementation of an expert clinical review of abstracted data for probable and confirmed cases classified through a computerized algorithm. FASSNetII abstracted data from multiple sources including birth records, medical records from child development centers or other specialty clinics, and administrative databases such as hospital discharge and Medicaid. One challenge of FASSNetII was its limited access to non-medical records. The FAS prevalence that could be estimated was that of the population identified through an encounter with the healthcare system. Clinical and public health programs that identify children affected by FAS provide critical information for targeting preventive, medical and educational services in this vulnerable population. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - O'Leary, Leslie A AU - Ortiz, Linnette AU - Montgomery, April AU - Fox, Deborah J AU - Cunniff, Christopher AU - Ruttenber, Margaret AU - Breen, April AU - Pettygrove, Sydney AU - Klumb, Don AU - Druschel, Charlotte AU - Frías, Jaime L AU - Robinson, Luther K AU - Bertrand, Jacquelyn AU - Ferrara, Kelly AU - Kelly, Maureen AU - Gilboa, Suzanne M AU - Meaney, F John AU - FASSNetII AD - Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia. ; FASSNetII Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 196 EP - 202 VL - 103 IS - 3 KW - Index Medicus KW - population-based surveillance KW - birth defects KW - clinical review KW - developmental disabilities KW - fetal alcohol syndrome KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Retrospective Studies KW - Child KW - Community Networks KW - United States -- epidemiology KW - Male KW - Female KW - Child, Preschool KW - Epidemiological Monitoring KW - Fetal Alcohol Spectrum Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666726036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Methods+for+surveillance+of+fetal+alcohol+syndrome%3A+The+Fetal+Alcohol+Syndrome+Surveillance+Network+II+%28FASSNetII%29+-+Arizona%2C+Colorado%2C+New+York%2C+2009+-+2014.&rft.au=O%27Leary%2C+Leslie+A%3BOrtiz%2C+Linnette%3BMontgomery%2C+April%3BFox%2C+Deborah+J%3BCunniff%2C+Christopher%3BRuttenber%2C+Margaret%3BBreen%2C+April%3BPettygrove%2C+Sydney%3BKlumb%2C+Don%3BDruschel%2C+Charlotte%3BFr%C3%ADas%2C+Jaime+L%3BRobinson%2C+Luther+K%3BBertrand%2C+Jacquelyn%3BFerrara%2C+Kelly%3BKelly%2C+Maureen%3BGilboa%2C+Suzanne+M%3BMeaney%2C+F+John%3BFASSNetII&rft.aulast=O%27Leary&rft.aufirst=Leslie&rft.date=2015-03-01&rft.volume=103&rft.issue=3&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23335 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-07 N1 - Date created - 2015-03-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Pediatr. 2010 Jun;156(6):907-13, 913.e1-2 [20304425] Dev Disabil Res Rev. 2009;15(3):176-92 [19731384] Birth Defects Res A Clin Mol Teratol. 2014 Feb;100(2):67-78 [24591358] Vital Health Stat 11. 2002 May;(246):1-190 [12043359] Pediatrics. 1966 Mar;37(3):403-8 [5906365] Teratology. 2002;66 Suppl 1:S41-9 [12239744] MMWR Morb Mortal Wkly Rep. 2002 May 24;51(20):433-5 [12056499] Lancet. 1973 Jun 9;1(7815):1267-71 [4126070] J Pediatr. 1987 Aug;111(2):267-8 [3612403] MMWR Morb Mortal Wkly Rep. 1993 May 7;42(17):339-41 [8479418] MMWR Morb Mortal Wkly Rep. 1995 Apr 7;44(13):249-51 [7898419] Obstet Gynecol. 1996 Feb;87(2):163-8 [8559516] Alcohol Clin Exp Res. 1995 Dec;19(6):1565-71 [8749828] MMWR Morb Mortal Wkly Rep. 1997 Nov 28;46(47):1118-20 [9393658] Birth Defects Res A Clin Mol Teratol. 2006 Nov;76(11):793-7 [17036307] Paediatr Perinat Epidemiol. 2007 Mar;21(2):179-90 [17302648] Neurotoxicol Teratol. 2011 Mar-Apr;33(2):322-4 [21073947] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23335 ER - TY - JOUR T1 - Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals AN - 1664197744; PQ0001232755 AB - In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference (S. J. Anthony, J. A. St Leger, K. Pugliares, H. S. Ip, J. M. Chan, Z. W. Carpenter, I. Navarrete-Macias, M. Sanchez-Leon, J. T. Saliki, J. Pedersen, W. Karesh, P. Daszak, R. Rabadan, T. Rowles, W. I. Lipkin, MBio 3:e00166-00112, 2012, http://dx.doi.org/10.1128/mBio.00166-12). Here, we present a detailed structural and biochemical analysis of the surface antigens of the virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for cross-species transmission, our results indicate that the A(H3N8) virus currently poses a low risk to humans. IMPORTANCE Cross-species transmission of zoonotic influenza viruses increases public health concerns. Here, we report a molecular and structural study of the major surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals. The results improve our understanding of these viruses as they evolve and provide important information to aid ongoing risk assessment analyses as these zoonotic influenza viruses continue to circulate and adapt to new hosts. JF - Journal of Virology AU - Yang, Hua AU - Nguyen, Ha T AU - Carney, Paul J AU - Guo, Zhu AU - Chang, Jessie C AU - Jones, Joyce AU - Davis, Charles T AU - Villanueva, Julie M AU - Gubareva, Larisa V AU - Stevens, James AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, fwb4@cdc.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 2801 EP - 2812 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 5 SN - 0022-538X, 0022-538X KW - Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - Risk assessment KW - Hemagglutinins KW - Nucleotide sequence KW - Viruses KW - Biochemical analysis KW - Infection KW - Disease transmission KW - Public health KW - Influenza KW - Antigens KW - USA, New England KW - Structure-function relationships KW - Risk factors KW - Exo- alpha -sialidase KW - Mortality KW - Adaptations KW - Receptors KW - Seals KW - Functional analysis KW - Recombinants KW - Adaptability KW - Influenza virus KW - surface antigens KW - Marine mammals KW - Proteins KW - New species KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - O 1050:Vertebrates, Urochordates and Cephalochordates KW - Q1 08604:Stock assessment and management KW - R2 23060:Medical and environmental health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664197744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Structural+and+Functional+Analysis+of+Surface+Proteins+from+an+A%28H3N8%29+Influenza+Virus+Isolated+from+New+England+Harbor+Seals&rft.au=Yang%2C+Hua%3BNguyen%2C+Ha+T%3BCarney%2C+Paul+J%3BGuo%2C+Zhu%3BChang%2C+Jessie+C%3BJones%2C+Joyce%3BDavis%2C+Charles+T%3BVillanueva%2C+Julie+M%3BGubareva%2C+Larisa+V%3BStevens%2C+James&rft.aulast=Yang&rft.aufirst=Hua&rft.date=2015-03-01&rft.volume=89&rft.issue=5&rft.spage=2801&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.02723-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 85 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Recombinants; Antigens; Nucleotide sequence; Marine mammals; Viruses; Receptors; Biochemical analysis; Public health; Disease transmission; Risk assessment; Influenza; Adaptations; surface antigens; Structure-function relationships; Risk factors; Hemagglutinins; Exo- alpha -sialidase; Infection; New species; Mortality; Adaptability; Proteins; Seals; Functional analysis; Influenza virus; USA, New England DO - http://dx.doi.org/10.1128/JVI.02723-14 ER - TY - JOUR T1 - Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry. AN - 1652434672; 25576235 AB - The seeds of the Ricinus communis (Castor bean) plant are the source of the economically important commodity castor oil. Castor seeds also contain the proteins ricin and R. communis agglutinin (RCA), two toxic lectins that are hazardous to human health. Radial immunodiffusion (RID) and the enzyme linked immunosorbent assay (ELISA) are two antibody-based methods commonly used to quantify ricin and RCA; however, antibodies currently used in these methods cannot distinguish between ricin and RCA due to the high sequence homology of the respective proteins. In this study, a technique combining antibody-based affinity capture with liquid chromatography and multiple reaction monitoring (MRM) mass spectrometry (MS) was used to quantify the amounts of ricin and RCA independently in extracts prepared from the seeds of eighteen representative cultivars of R. communis which were propagated under identical conditions. Additionally, liquid chromatography and MRM-MS was used to determine rRNA N-glycosidase activity for each cultivar and the overall activity in these cultivars was compared to a purified ricin standard. Of the cultivars studied, the average ricin content was 9.3 mg/g seed, the average RCA content was 9.9 mg/g seed, and the enzymatic activity agreed with the activity of a purified ricin reference within 35% relative activity. Published by Elsevier Ltd. JF - Toxicon : official journal of the International Society on Toxinology AU - Schieltz, David M AU - McWilliams, Lisa G AU - Kuklenyik, Zsuzsanna AU - Prezioso, Samantha M AU - Carter, Andrew J AU - Williamson, Yulanda M AU - McGrath, Sara C AU - Morse, Stephen A AU - Barr, John R AD - Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway N.E., MS-F50, Atlanta, GA 30341, USA. ; Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Center for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. ; Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway N.E., MS-F50, Atlanta, GA 30341, USA. Electronic address: jbarr@cdc.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 72 EP - 83 VL - 95 KW - Plant Extracts KW - 0 KW - Plant Lectins KW - Ricinus communis agglutinin-1 KW - Ricin KW - 9009-86-3 KW - Glycoside Hydrolases KW - EC 3.2.1.- KW - Index Medicus KW - Cultivar KW - RCA KW - Mass spectrometry KW - Quantification KW - Ricinus communis KW - Seeds -- chemistry KW - Glycoside Hydrolases -- metabolism KW - Electrophoresis, Polyacrylamide Gel KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Plant Extracts -- chemistry KW - Immunoassay KW - Castor Bean -- chemistry KW - Castor Bean -- enzymology KW - Ricin -- chemistry KW - Plant Lectins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652434672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Quantification+of+ricin%2C+RCA+and+comparison+of+enzymatic+activity+in+18+Ricinus+communis+cultivars+by+isotope+dilution+mass+spectrometry.&rft.au=Schieltz%2C+David+M%3BMcWilliams%2C+Lisa+G%3BKuklenyik%2C+Zsuzsanna%3BPrezioso%2C+Samantha+M%3BCarter%2C+Andrew+J%3BWilliamson%2C+Yulanda+M%3BMcGrath%2C+Sara+C%3BMorse%2C+Stephen+A%3BBarr%2C+John+R&rft.aulast=Schieltz&rft.aufirst=David&rft.date=2015-03-01&rft.volume=95&rft.issue=&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=1879-3150&rft_id=info:doi/10.1016%2Fj.toxicon.2015.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-14 N1 - Date created - 2015-02-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxicon.2015.01.003 ER - TY - JOUR T1 - The Childhood Obesity Research Demonstration Project: A Team Approach for Supporting a Multisite, Multisector Intervention AN - 1780513970; PQ0002687393 AB - Background: Comprehensive multisector, multilevel approaches are needed to address childhood obesity. This article introduces the structure of a multidisciplinary team approach used to support and guide the multisite, multisector interventions implemented as part of the Childhood Obesity Research Demonstration (CORD) project. This article will describe the function, roles, and lessons learned from the CDC-CORD approach to project management. Methods: The CORD project works across multisectors and multilevels in three demonstration communities. Working with principal investigators and their research teams who are engaging multiple stakeholder groups, including community organizations, schools and child care centers, health departments, and healthcare providers, can be a complex endeavor. To best support the community-based research project, scientific and programmatic expertise in a wide range of areas was required. The team was configured based on the skill sets needed to interact with the various levels of staff working with the project. Conclusions: By thoughtful development of the team and processes, an efficient system for supporting the multisite, multisector intervention project sites was developed. The team approach will be formally evaluated at the end of the project period. JF - Childhood Obesity AU - Williams, Nancy AU - Dooyema, Carrie A AU - Foltz, Jennifer L AU - Belay, Brook AU - Blanck, Heidi M AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 104 EP - 108 PB - Mary Ann Liebert, Inc. Publishers, 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 11 IS - 1 SN - 2153-2168, 2153-2168 KW - Physical Education Index KW - Obesity KW - Management KW - Day care centers KW - Community health KW - Team sports KW - Associations KW - Work KW - Expertise KW - School health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780513970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Childhood+Obesity&rft.atitle=The+Childhood+Obesity+Research+Demonstration+Project%3A+A+Team+Approach+for+Supporting+a+Multisite%2C+Multisector+Intervention&rft.au=Williams%2C+Nancy%3BDooyema%2C+Carrie+A%3BFoltz%2C+Jennifer+L%3BBelay%2C+Brook%3BBlanck%2C+Heidi+M&rft.aulast=Williams&rft.aufirst=Nancy&rft.date=2015-02-01&rft.volume=11&rft.issue=1&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Childhood+Obesity&rft.issn=21532168&rft_id=info:doi/10.1089%2Fchi.2014.0063 LA - English DB - Physical Education Index N1 - Date revised - 2016-04-01 N1 - Number of references - 12 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Obesity; Day care centers; Management; Community health; Associations; Team sports; Expertise; Work; School health DO - http://dx.doi.org/10.1089/chi.2014.0063 ER - TY - JOUR T1 - Childhood Obesity Research Demonstration (CORD): The Cross-Site Overview and Opportunities for Interventions Addressing Obesity Community-Wide AN - 1780512333; PQ0002687394 AB - Background: This is the first of a set of articles in this issue on the Childhood Obesity Research Demonstration (CORD) project and provides an overview of the multisite approach and community-wide interventions. Innovative multisetting, multilevel approaches that integrate primary healthcare and public health interventions to improve outcomes for children with obesity need to be evaluated. The CORD project aims to improve BMI and obesity-related behaviors among underserved 2- to 12-year-old children by utilizing these approaches. Methods: The CORD consortium, structure, model terminology and key components, and common measures were solidified in year 1 of the CORD project. Demonstration sites applied the CORD model across communities in years 2 and 3. Evaluation plans for year 4 include site-specific analyses as well as cross-site impact, process, and sustainability evaluations. Results: The CORD approach resulted in commonalities and differences in participant, intervention, comparison, and outcome elements across sites. Products are to include analytic results as well as cost assessment, lessons learned, tools, and materials. Discussion: Foreseen opportunities and challenges arise from the similarities and unique aspects across sites. Communities adapted interventions to fit their local context and build on strengths, but, in turn, this flexibility makes cross-site evaluation challenging. Conclusion: The CORD project represents an evidence-based approach that integrates primary care and public health strategies and evaluates multisetting multilevel interventions, thus adding to the limited research in this field. CORD products will be disseminated to a variety of stakeholders to aid the understanding, prevention, and management of childhood obesity. JF - Childhood Obesity AU - Foltz, Jennifer L AU - Belay, Brook AU - Dooyema, Carrie A AU - Williams, Nancy AU - Blanck, Heidi M AD - Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 4 EP - 10 PB - Mary Ann Liebert, Inc. Publishers, 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 11 IS - 1 SN - 2153-2168, 2153-2168 KW - Physical Education Index KW - Evaluation KW - Obesity KW - Preventive health KW - Objectives KW - Flexibility KW - Analysis KW - Strategy KW - Children KW - Public health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780512333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Childhood+Obesity&rft.atitle=Childhood+Obesity+Research+Demonstration+%28CORD%29%3A+The+Cross-Site+Overview+and+Opportunities+for+Interventions+Addressing+Obesity+Community-Wide&rft.au=Foltz%2C+Jennifer+L%3BBelay%2C+Brook%3BDooyema%2C+Carrie+A%3BWilliams%2C+Nancy%3BBlanck%2C+Heidi+M&rft.aulast=Foltz&rft.aufirst=Jennifer&rft.date=2015-02-01&rft.volume=11&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Childhood+Obesity&rft.issn=21532168&rft_id=info:doi/10.1089%2Fchi.2014.0159 LA - English DB - Physical Education Index N1 - Date revised - 2016-04-01 N1 - Number of references - 28 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Preventive health; Analysis; Flexibility; Objectives; Strategy; Children; Public health DO - http://dx.doi.org/10.1089/chi.2014.0159 ER - TY - JOUR T1 - HIV STIGMA EXPERIENCED BY YOUNG MEN WHO HAVE SEX WITH MEN (MSM) LIVING WITH HIV INFECTION AN - 1752993587; 201600087 AB - Stigma can compromise the health of persons living with HIV. Although HIV is increasingly affecting young men who have sex with men (MSM), little is known about their experiences with HIV stigma. We used narrative data to examine HIV stigma experienced by young MSM living with HIV. Data came from 28 qualitative interviews with young MSM. We used inductive content analysis to identify themes across these interviews. Participants commonly discussed negative perceptions and treatment of persons living with HIV. Stigma could result in nondisclosure of HIV status, internalized stigma, and avoidance of HIV-related things. Some men discussed strategies that might combat stigma. Findings suggest that HIV stigma might challenge young MSM's health by undermining health-conducive resources (e.g., social support) and contributing to HIV vulnerability. Interventions that counteract HIV stigma may help to create environments that promote well-being among young MSM living with HIV. Adapted from the source document. JF - AIDS Education and Prevention AU - Jeffries, William L AU - Townsend, Ebony Symone AU - Gelaude, Deborah J AU - Torrone, Elizabeth A AU - Gasiorowicz, Mari AU - Bertolli, Jeanne AD - Centers for Disease Control and Prevention, 1600 Clifton Rd., MS E37, Atlanta, GA 30333; Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention wjeffries@cdc.gov Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 58 EP - 71 PB - Guilford Publications, New York NY VL - 27 IS - 1 SN - 0899-9546, 0899-9546 KW - Well Being KW - Males KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Social Support KW - Health KW - Vulnerability KW - Homosexuality KW - Stigma KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752993587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Education+and+Prevention&rft.atitle=HIV+STIGMA+EXPERIENCED+BY+YOUNG+MEN+WHO+HAVE+SEX+WITH+MEN+%28MSM%29+LIVING+WITH+HIV+INFECTION&rft.au=Jeffries%2C+William+L%3BTownsend%2C+Ebony+Symone%3BGelaude%2C+Deborah+J%3BTorrone%2C+Elizabeth+A%3BGasiorowicz%2C+Mari%3BBertolli%2C+Jeanne&rft.aulast=Jeffries&rft.aufirst=William&rft.date=2015-02-01&rft.volume=27&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=AIDS+Education+and+Prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2016-01-01 N1 - Number of references - 28 N1 - Last updated - 2016-09-28 N1 - CODEN - AEPREO N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Stigma; Homosexuality; Health; Well Being; Vulnerability; Intervention; Males; Social Support ER - TY - JOUR T1 - Q Fever is Underestimated in the United States: A Comparison of Fatal Q Fever Cases from Two National Reporting Systems AN - 1722168218; PQ0002108414 AB - Two national surveillance systems capturing reports of fatal Q fever were compared with obtained estimates of Q fever underreporting in the United States using capture-recapture methods. During 2000-2011, a total of 33 unique fatal Q fever cases were reported through case report forms submitted to the Centers for Disease Control and Prevention and through U.S. death certificate data. A single case matched between both data sets, yielding an estimated 129 fatal cases (95% confidence interval [CI] = 62-1,250) during 2000-2011. Fatal cases of Q fever were underreported through case report forms by an estimated factor of 14 and through death certificates by an estimated factor of 5.2. JF - American Journal of Tropical Medicine and Hygiene AU - Dahlgren, F Scott AU - Haberling, Dana L AU - McQuiston, Jennifer H AD - Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, iot0@cdc.gov Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 244 EP - 246 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 2 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Comparative studies KW - USA KW - Data processing KW - Case reports KW - Surveillance and enforcement KW - Disease control KW - Hygiene KW - Q fever KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Q+Fever+is+Underestimated+in+the+United+States%3A+A+Comparison+of+Fatal+Q+Fever+Cases+from+Two+National+Reporting+Systems&rft.au=Dahlgren%2C+F+Scott%3BHaberling%2C+Dana+L%3BMcQuiston%2C+Jennifer+H&rft.aulast=Dahlgren&rft.aufirst=F&rft.date=2015-02-01&rft.volume=92&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Comparative studies; Disease control; Surveillance and enforcement; Hygiene; Data processing; Case reports; Q fever; USA DO - http://dx.doi.org/10.4269/ajtmh.14-0502 ER - TY - JOUR T1 - Incrimination of Aedes (Stegomyia) hensilli Farner as an Epidemic Vector of Chikungunya Virus on Yap Island, Federated States of Micronesia, 2013 AN - 1722166840; PQ0002108443 AB - Two species of Aedes (Stegomyia) were collected in response to the first Chikungunya virus (CHIKV) outbreak on Yap Island: the native species Ae. hensilli Farner and the introduced species Ae. aegypti (L.). Fourteen CHIKV-positive mosquito pools were detected. Six pools were composed of female Ae. hensilli, six pools were composed of female Ae. aegypti, one pool was composed of male Ae. hensilli, and one pool contained female specimens identified as Ae. (Stg.) spp. Infection rates were not significantly different between female Ae. hensilli and Ae. aegypti. The occurrence of human cases in all areas of Yap Island and the greater number of sites that yielded virus from Ae. hensilli combined with the ubiquitous distribution of this species incriminate Ae. hensilli as the most important vector of CHIKV during the outbreak. Phylogenic analysis shows that virus strains on Yap are members of the Asia lineage and closely related to strains currently circulating in the Caribbean. JF - American Journal of Tropical Medicine and Hygiene AU - Savage, Harry M AU - Ledermann, Jeremy P AU - Yug, Laurence AU - Burkhalter, Kristen L AU - Marfel, Maria AU - Hancock, W Thane AD - Centers for Disease Control and Prevention, Fort Collins, Colorado, hms1@cdc.gov Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 429 EP - 436 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 2 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Virology & AIDS Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Marine KW - Aedes KW - Chikungunya virus KW - Epidemics KW - Caroline I., Micronesia KW - Vectors KW - Hosts KW - Infection KW - Strains KW - Public health KW - Disease transmission KW - Ocean currents KW - Indigenous species KW - ASW, Caribbean Sea KW - Islands KW - ISEW, Caroline Is., Micronesia, Yap I. KW - Micronesia, Fed. States KW - Asia KW - Hygiene KW - Introduced species KW - Aquatic insects KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722166840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Incrimination+of+Aedes+%28Stegomyia%29+hensilli+Farner+as+an+Epidemic+Vector+of+Chikungunya+Virus+on+Yap+Island%2C+Federated+States+of+Micronesia%2C+2013&rft.au=Savage%2C+Harry+M%3BLedermann%2C+Jeremy+P%3BYug%2C+Laurence%3BBurkhalter%2C+Kristen+L%3BMarfel%2C+Maria%3BHancock%2C+W+Thane&rft.aulast=Savage&rft.aufirst=Harry&rft.date=2015-02-01&rft.volume=92&rft.issue=2&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0374 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Ocean currents; Epidemics; Hosts; Introduced species; Hygiene; Strains; Aquatic insects; Disease transmission; Public health; Indigenous species; Islands; Vectors; Infection; Aedes; Chikungunya virus; ASW, Caribbean Sea; Caroline I., Micronesia; ISEW, Caroline Is., Micronesia, Yap I.; Micronesia, Fed. States; Asia; Marine DO - http://dx.doi.org/10.4269/ajtmh.14-0374 ER - TY - JOUR T1 - The occupational hazards in field operation and the protection measures for epidemic prevention workers AN - 1705067069; PQ0001823485 AB - This article introduces the occupational hazards in field operation for epidemic prevention workers and discusses the principles for protection. Some effective protective measures are put forward. JF - Chinese Journal of Hygienic Insecticides & Equipment AU - DENG, Bing AU - YANG, Hui AU - YANG, Hui-suo AU - WANG, Zheng AD - Center for Disease Control and Prevention of Beijing Command, Beijing 100042, Chirm Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 96 EP - 97 PB - Editorial Department of the Chinese Journal of Hygienic Insecticides & Equipment, 293 Zhongshan East Road Nanjing, Jiangsu Province, 210002 China VL - 21 IS - 1 SN - 1671-2781, 1671-2781 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - epidemic prevention workers KW - occupational hazards KW - protective measures KW - Hazards KW - Workers KW - Prevention KW - Epidemics KW - Insecticides KW - Occupational hazards KW - Hygiene KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705067069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.atitle=The+occupational+hazards+in+field+operation+and+the+protection+measures+for+epidemic+prevention+workers&rft.au=DENG%2C+Bing%3BYANG%2C+Hui%3BYANG%2C+Hui-suo%3BWANG%2C+Zheng&rft.aulast=DENG&rft.aufirst=Bing&rft.date=2015-02-01&rft.volume=21&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Chinese+Journal+of+Hygienic+Insecticides+%26+Equipment&rft.issn=16712781&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Workers; Insecticides; Epidemics; Occupational hazards; Hygiene; Hazards; Prevention ER - TY - JOUR T1 - Detection of type III secretion system in Vibrio parahaemolyticus from food poison cases and clinical diarrhea patients AN - 1680441787; PQ0001384328 AB - Objective: To investigate the distribution of type III secretion system and antimicrobial resistance of Vibiro parahemolyticus. Methods: The strains were isolated from food poison cases and clinical diarrhea patients. 21 strains were examined for the tdh, trh, T3SS1, T3SS2 alpha , T3SS2 beta and toxR by PCR. The VITEK system was adopted for the detection of antimicrobial resistance. Results: 19 (90.48%) isolates were tdh(+)/trh(-), 1 (4.76%) isolate from clinical diarrhea was tdh(-)/trh(+) and 1(4.76%) strain from food poison cases was tdh(+)/trh(-). T3SS1 existed ubiquitously in the 21 isolates. T3SS2 alpha was shown to be associated with tdh(+)/trh(-), and was found in all the 19 tdh(+)/trh(-) strains. T3SS2 beta was present in tdh(-)/trh(+) strains. The tdh(-)/trh(-) isolate was negative for T3SS2 alpha and T3SS2 beta . All the 21 isolates were sensitive to amoxicillin, cefepime, amikacin, gentamicin, ciprofloxacin and trimethoprim, while resistant to ampicillin. Conclusion: The isolates from different origins were mostly (90.48%) tdh(+). The tdh was associated with T3SS2 alpha and trh with T3SS2 beta . The tdh(-)/trh(-)/T3SS2 alpha (-)/T3SS2 beta (-) isolate indicated that there are other virulence factors remained to be identified. JF - Chinese Journal of Microecology AU - Shao, Zhan-Tao AU - Li, Ying AU - Wang, Yuan-Yuan AU - Zhu, Mei-Juan AU - Wang, Yan-Bo AD - Shunyi District Center for Disease Control and Prevention, Beijing 101300, shaozhantao@hotmail.com PY - 2015 SP - 159 EP - 162 PB - Editorial Department of Chinese Journal of Microecology, 465 Zhongshan Road Dalian 116027 China VL - 27 IS - 2 SN - 1005-376X, 1005-376X KW - Microbiology Abstracts B: Bacteriology KW - Amoxicillin KW - Trimethoprim KW - Diarrhea KW - Amikacin KW - virulence factors KW - Secretion KW - Drug resistance KW - Ampicillin KW - Food poisoning KW - Gentamicin KW - Ciprofloxacin KW - Cefepime KW - Vibrio parahaemolyticus KW - Polymerase chain reaction KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680441787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Family+Practice&rft.atitle=Effects+of+educational+outreach+visits+on+prescribing+of+benzodiazepines+and+antipsychotic+drugs+to+elderly+patients+in+primary+health+care+in+southern+Sweden&rft.au=Midl%C3%B6v%2C+Patrik%3BBondesson%2C+%C3%85sa%3BEriksson%2C+Tommy%3BNerbrand%2C+Christina%3BH%C3%B6glund%2C+Peter&rft.aulast=Midl%C3%B6v&rft.aufirst=Patrik&rft.date=2006-02-01&rft.volume=23&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Family+Practice&rft.issn=02632136&rft_id=info:doi/10.1093%2Ffampra%2Fcmi105 LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Trimethoprim; Amoxicillin; Diarrhea; virulence factors; Amikacin; Drug resistance; Secretion; Food poisoning; Ampicillin; Gentamicin; Ciprofloxacin; Cefepime; Polymerase chain reaction; Vibrio parahaemolyticus DO - http://dx.doi.org/10.13381/j.cnki.cjm.201502009 ER - TY - JOUR T1 - Epidemiology of twinning in the National Birth Defects Prevention Study, 1997 to 2007. AN - 1669835855; 25359509 AB - Our objective was to evaluate associations between twinning and maternal demographic factors and periconceptional exposures among infants with and without orofacial clefts. We used data from the National Birth Defects Prevention Study; 228 twins and 8242 singletons without birth defects (controls), and 117 twins and 2859 singletons with orofacial clefts, born 1997 to 2007, were included in the analyses. Because of the occurrence of twinning due to the use of assisted reproductive technologies, logistic regression models were computed to estimate odds ratios and 95% confidence intervals for each exposure, stratified by fertility treatment use. To evaluate factors by zygosity, we used sex-pairing data and a simulation approach to estimate the zygosity of like-sex twin pairs for unassisted conceptions. Among control mothers who did not use fertility treatments, predictors of twinning included non-Hispanic black maternal race (adjusted odds ratio, 1.6; 95% confidence interval, 1.0-2.4), and tobacco smoking (adjusted odds ratio, 1.6; 95% confidence interval, 1.1-2.4). Among control mothers who used fertility treatments, older maternal age, higher income, and state of residence were associated with twinning. Associations were generally stronger among mothers of dizygotic (estimated) twins than monozygotic (estimated) twins. Results for mothers of infants with isolated orofacial clefts were similar to those of controls. We observed an increased twinning frequency with increasing maternal age, but factors such as maternal race/ethnicity and socioeconomic status may also contribute. Among women receiving fertility treatments, factors associated with twinning suggested a relation with treatment specifics (e.g., treatment type and number of embryos implanted) and availability of insurance coverage. © 2014 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Dawson, April L AU - Tinker, Sarah C AU - Jamieson, Denise J AU - Hobbs, Charlotte A AU - Rasmussen, Sonja A AU - Reefhuis, Jennita AU - National Birth Defects Prevention Study AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia; Oak Ridge Institute for Science and Education, Oak Ridge, Tennessee. ; National Birth Defects Prevention Study Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 85 EP - 99 VL - 103 IS - 2 KW - Index Medicus KW - ART KW - IVF KW - clomiphene citrate KW - twinning KW - orofacial clefts KW - Odds Ratio KW - Insurance, Health -- statistics & numerical data KW - Humans KW - Retrospective Studies KW - African Americans KW - Pregnancy KW - Smoking -- physiopathology KW - Hispanic Americans KW - Logistic Models KW - Maternal Age KW - European Continental Ancestry Group KW - Adult KW - Health Surveys KW - Income -- statistics & numerical data KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Male KW - Cleft Lip -- pathology KW - Cleft Lip -- epidemiology KW - Brain -- abnormalities KW - Cleft Palate -- pathology KW - Reproductive Techniques, Assisted -- statistics & numerical data KW - Cleft Palate -- epidemiology KW - Cleft Lip -- ethnology KW - Brain -- pathology KW - Twins, Dizygotic -- statistics & numerical data KW - Cleft Palate -- ethnology KW - Twins, Monozygotic -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669835855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Epidemiology+of+twinning+in+the+National+Birth+Defects+Prevention+Study%2C+1997+to+2007.&rft.au=Dawson%2C+April+L%3BTinker%2C+Sarah+C%3BJamieson%2C+Denise+J%3BHobbs%2C+Charlotte+A%3BRasmussen%2C+Sonja+A%3BReefhuis%2C+Jennita%3BNational+Birth+Defects+Prevention+Study&rft.aulast=Dawson&rft.aufirst=April&rft.date=2015-02-01&rft.volume=103&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23325 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-02-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hum Reprod Update. 1999 Mar-Apr;5(2):179-87 [10336022] Am J Med Genet. 1999 Mar 12;83(2):117-24 [10190482] Paediatr Perinat Epidemiol. 2005 Jan;19 Suppl 1:8-9 [15670115] Obstet Gynecol. 2005 Mar;105(3):593-7 [15738030] Matern Child Health J. 2006 Jan;10(1):75-81 [16240077] Med J Aust. 2007 Mar 5;186(5):243-8 [17391087] Hum Reprod. 2008 Aug;23(8):1941-8 [18487216] Reproduction. 2008 Oct;136(4):377-86 [18577552] Twin Res Hum Genet. 2009 Feb;12(1):79-85 [19210182] Fertil Steril. 2010 Feb;93(3):885-93 [19061995] Am J Obstet Gynecol. 2010 Oct;203(4):305-15 [20728073] Eur J Obstet Gynecol Reprod Biol. 2010 Dec;153(2):138-42 [20674134] Birth Defects Res A Clin Mol Teratol. 2011 Jan;91(1):34-8 [20890935] Twin Res Hum Genet. 2011 Feb;14(1):98-103 [21314262] Fertil Steril. 2011 Mar 1;95(3):964-9 [20688327] Hum Reprod. 2011 Aug;26(8):2247-52 [21669967] MMWR Surveill Summ. 2012 Nov 2;61(7):1-23 [23114281] N Engl J Med. 2013 Dec 5;369(23):2218-25 [24304051] Natl Vital Stat Rep. 2013 Jun 28;62(1):1-69, 72 [24974591] Public Health Rep. 2001;116 Suppl 1:32-40 [11889273] Obstet Gynecol. 2000 Jun;95(6 Pt 1):899-904 [10831988] Fertil Steril. 2011 Jul;96(1):95-101 [21616487] Natl Vital Stat Rep. 1999 Sep 14;47(24):1-16 [11968567] Lancet. 2003 Feb 1;361(9355):380-4 [12573374] Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):193-201 [12797461] Birth Defects Res A Clin Mol Teratol. 2003 Oct;67(10):879-85 [14745942] BMJ. 2004 Jan 31;328(7434):261 [14742347] JAMA. 2004 Apr 7;291(13):1564-6 [15069042] N Engl J Med. 1977 Sep 1;297(9):468-71 [887128] Vital Health Stat 2. 1980;(83):1-44 [7395112] Acta Genet Med Gemellol (Roma). 1981;30(3):189-202 [6805197] Ann Hum Biol. 1983 Sep-Oct;10(5):409-15 [6638936] Acta Med Scand. 1988;224(5):491-4 [3264449] Acta Genet Med Gemellol (Roma). 1990;39(3):317-28 [2085067] Vital Health Stat 2. 1993 Mar;(116):1-19 [8328134] N Engl J Med. 1994 Jun 9;330(23):1687-8 [8177283] Am J Med Genet. 1997 Jul 11;71(1):93-6 [9215776] N Engl J Med. 1998 Aug 27;339(9):573-7 [9718375] Epidemiology. 1999 Jan;10(1):37-48 [9888278] Behav Genet. 1999 Mar;29(2):115-23 [10405460] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23325 ER - TY - JOUR T1 - A Multicomponent School‐Based Asthma Management Program: Enhancing Connections to Clinical Care AN - 1665155560 JF - The Journal of School Health AU - Cheung, Karen AU - Rasberry, Catherine N AU - Dunville, Richard L AU - Buckley, Rebekah AU - Cook, Deborah AU - Daniels, Brandy AU - Robin, Leah AD - ICF International karen.cheung@icfi.com Brandy.Daniels@icfi.com; Centers for Disease Control and Prevention, National Center for HIV/AIDS. Viral Hepatitis, STD, and TB Prevention, Division of Adolescent Health RDunville@cdc.gov RDunville@cdc.gov RDunville@cdc.gov; Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion, Division of Population Health eut9@cdc.gov; Kennett Public Schools ; ICF International Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 135 EP - 140 CY - Kent PB - Wiley Subscription Services, Inc. VL - 85 IS - 2 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Asthma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665155560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=A+Multicomponent+School%E2%80%90Based+Asthma+Management+Program%3A+Enhancing+Connections+to+Clinical+Care&rft.au=Cheung%2C+Karen%3BRasberry%2C+Catherine+N%3BDunville%2C+Richard+L%3BBuckley%2C+Rebekah%3BCook%2C+Deborah%3BDaniels%2C+Brandy%3BRobin%2C+Leah&rft.aulast=Cheung&rft.aufirst=Karen&rft.date=2015-02-01&rft.volume=85&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12226 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-13 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1111/josh.12226 ER - TY - JOUR T1 - Molecular Mechanisms of Fluconazole Resistance in Candida parapsilosis Isolates from a U.S. Surveillance System AN - 1660441678; PQ0001092240 AB - Candida parapsilosis is the second or third most common cause of candidemia in many countries. The Infectious Diseases Society of America recommends fluconazole as the primary therapy for C. parapsilosis candidemia. Although the rate of fluconazole resistance among C. parapsilosis isolates is low in most U.S. institutions, the resistance rate can be as high as 7.5%. This study was designed to assess the mechanisms of fluconazole resistance in 706 incident bloodstream isolates from U.S. hospitals. We sequenced the ERG11 and MRR1 genes of 122 C. parapsilosis isolates with resistant (30 isolates; 4.2%), susceptible dose-dependent (37 isolates; 5.2%), and susceptible (55 isolates) fluconazole MIC values and used real-time PCR of RNA from 17 isolates to investigate the regulation of MDR1. By comparing these isolates to fully fluconazole-susceptible isolates, we detected at least two mechanisms of fluconazole resistance: an amino acid substitution in the 14- alpha -demethylase gene ERG11 and overexpression of the efflux pump MDR1, possibly due to point mutations in the MRR1 transcription factor that regulates MDR1. The ERG11 single nucleotide polymorphism (SNP) was found in 57% of the fluconazole-resistant isolates and in no susceptible isolates. The MRR1 SNPs were more difficult to characterize, as not all resulted in overexpression of MDR1 and not all MDR1 overexpression was associated with an SNP in MRR1. Further work to characterize the MRR1 SNPs and search for overexpression of other efflux pumps is needed. JF - Antimicrobial Agents & Chemotherapy AU - Grossman, Nina T AU - Pham, Cau D AU - Cleveland, Angela A AU - Lockhart, Shawn R Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 1030 EP - 1037 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Molecular modelling KW - Amino acid substitution KW - Candidemia KW - Point mutation KW - MDR1 protein KW - Minimum inhibitory concentration KW - fluconazole KW - RNA KW - Infectious diseases KW - Single-nucleotide polymorphism KW - Transcription factors KW - Polymerase chain reaction KW - Candida parapsilosis KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660441678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Molecular+Mechanisms+of+Fluconazole+Resistance+in+Candida+parapsilosis+Isolates+from+a+U.S.+Surveillance+System&rft.au=Grossman%2C+Nina+T%3BPham%2C+Cau+D%3BCleveland%2C+Angela+A%3BLockhart%2C+Shawn+R&rft.aulast=Grossman&rft.aufirst=Nina&rft.date=2015-02-01&rft.volume=59&rft.issue=2&rft.spage=1030&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04613-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 29 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Amino acid substitution; Candidemia; Point mutation; MDR1 protein; Minimum inhibitory concentration; fluconazole; Infectious diseases; RNA; Single-nucleotide polymorphism; Transcription factors; Polymerase chain reaction; Hospitals; Candida parapsilosis DO - http://dx.doi.org/10.1128/AAC.04613-14 ER - TY - JOUR T1 - First Report of an Infant Botulism Case Due to Clostridium botulinum Type Af AN - 1660439354; PQ0001092476 AB - Most infant botulism cases worldwide are due to botulinum toxin types A and B. Rarely, Clostridium botulinum strains that produce two serotypes (Ab, Ba, and Bf) have also been isolated from infant botulism cases. This is the first reported case of infant botulism due to C. botulinum type Af worldwide. JF - Journal of Clinical Microbiology AU - de Jong, Laura IT AU - Fernandez, Rafael A AU - Pareja, Virtudes AU - Giaroli, Gabriel AU - Guidarelli, Sergio R AU - Dykes, Janet K AU - Luquez, Carolina AD - Area Microbiologia, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina, CLuquez@cdc.gov. PY - 2015 SP - 740 EP - 742 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 2 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Antibodies KW - Serotypes KW - Botulism KW - Clostridium botulinum KW - Botulinum toxin KW - Infants KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660439354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=First+Report+of+an+Infant+Botulism+Case+Due+to+Clostridium+botulinum+Type+Af&rft.au=de+Jong%2C+Laura+IT%3BFernandez%2C+Rafael+A%3BPareja%2C+Virtudes%3BGiaroli%2C+Gabriel%3BGuidarelli%2C+Sergio+R%3BDykes%2C+Janet+K%3BLuquez%2C+Carolina&rft.aulast=de+Jong&rft.aufirst=Laura&rft.date=2015-02-01&rft.volume=53&rft.issue=2&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02894-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 16 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Antibodies; Serotypes; Botulism; Botulinum toxin; Infants; Clostridium botulinum DO - http://dx.doi.org/10.1128/JCM.02894-14 ER - TY - JOUR T1 - Bacteriophage-Mediated Control of a Two-Species Biofilm Formed by Microorganisms Causing Catheter-Associated Urinary Tract Infections in an In Vitro Urinary Catheter Model AN - 1660438578; PQ0001092180 AB - Microorganisms from a patient or their environment may colonize indwelling urinary catheters, forming biofilm communities on catheter surfaces and increasing patient morbidity and mortality. This study investigated the effect of pretreating hydrogel-coated silicone catheters with mixtures of Pseudomonas aeruginosa and Proteus mirabilis bacteriophages on the development of single- and two-species biofilms in a multiday continuous-flow in vitro model using artificial urine. Novel phages were purified from sewage, characterized, and screened for their abilities to reduce biofilm development by clinical isolates of their respective hosts. Our screening data showed that artificial urine medium (AUM) is a valid substitute for human urine for the purpose of evaluating uropathogen biofilm control by these bacteriophages. Defined phage cocktails targeting P. aeruginosa and P. mirabilis were designed based on the biofilm inhibition screens. Hydrogel-coated catheters were pretreated with one or both cocktails and challenged with approximately 1 103 CFU/ml of the corresponding pathogen(s). The biofilm growth on the catheter surfaces in AUM was monitored over 72 to 96 h. Phage pretreatment reduced P. aeruginosa biofilm counts by 4 log10 CFU/cm2 (P less than or equal to 0.01) and P. mirabilis biofilm counts by >2 log10 CFU/cm2 (P less than or equal to 0.01) over 48 h. The presence of P. mirabilis was always associated with an increase in lumen pH from 7.5 to 9.5 and with eventual blockage of the reactor lines. The results of this study suggest that pretreatment of a hydrogel urinary catheter with a phage cocktail can significantly reduce mixed-species biofilm formation by clinically relevant bacteria. JF - Antimicrobial Agents & Chemotherapy AU - Lehman, Susan M AU - Donlan, Rodney M Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 1127 EP - 1137 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 2 SN - 0066-4804, 0066-4804 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Phages KW - Bacteria KW - Mortality KW - Data processing KW - Silicones KW - Urinary tract KW - Infection KW - Proteus mirabilis KW - Morbidity KW - Models KW - hydrogels KW - Sewage KW - Urine KW - Bioreactors KW - Colony-forming cells KW - Microorganisms KW - Catheters KW - Biofilms KW - Pseudomonas aeruginosa KW - pH effects KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660438578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Bacteriophage-Mediated+Control+of+a+Two-Species+Biofilm+Formed+by+Microorganisms+Causing+Catheter-Associated+Urinary+Tract+Infections+in+an+In+Vitro+Urinary+Catheter+Model&rft.au=Lehman%2C+Susan+M%3BDonlan%2C+Rodney+M&rft.aulast=Lehman&rft.aufirst=Susan&rft.date=2015-02-01&rft.volume=59&rft.issue=2&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.03786-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 70 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Phages; Clinical isolates; Mortality; Data processing; Silicones; Urinary tract; Infection; Morbidity; Models; Sewage; hydrogels; Urine; Colony-forming cells; Bioreactors; Catheters; Microorganisms; Biofilms; pH effects; Bacteria; Pseudomonas aeruginosa; Proteus mirabilis DO - http://dx.doi.org/10.1128/AAC.03786-14 ER - TY - JOUR T1 - Correlates of Sexual Risk for HIV Among US-Born and Foreign-Born Latino Men Who Have Sex with Men (MSM): An Analysis from the Brothers y Hermanos Study AN - 1660405512; PQ0001017019 AB - Little research has been conducted to examine whether correlates of sexual risk vary by nativity among Latino men who have sex with men (MSM). We used cross sectional data collected from 870 Latino MSM recruited with respondent-driven sampling techniques. For each sub-sample (US-born and foreign-born), we assessed the association between each of the potential correlates (substance use, acculturation, social support, and social discrimination) and sexual risk behavior. Illicit drug use was associated with increased odds of sexual risk behavior in both US-born (OR = 2.17, 95 % CI 1.17-4.03) and foreign-born (OR = 1.86, 1.14-3.05) subgroups. Multivariate correlates specific to foreign-born men included binge drinking (OR = 1.91, 1.17-3.14), 15 years or longer spent in the US (OR = 1.79, 1.06-3.03) and exposure to social discrimination (OR = 2.02, 1.03-3.99). Given the diversity of Latino MSM, information from research that identifies both common and different HIV risk factors across subgroups of Latino MSM may help better tailor HIV prevention programs. JF - Journal of Immigrant and Minority Health AU - Mizuno, Yuko AU - Borkowf, Craig B AU - Ayala, George AU - Carballo-Dieguez, Alex AU - Millett, Gregorio A AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, NE Mail Stop E37, Atlanta, GA, 30333, USA, ymizuno@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 47 EP - 55 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 1 SN - 1557-1912, 1557-1912 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Binge drinking KW - Immigrants KW - Discrimination KW - Homosexuality KW - Drug abuse KW - Substance use KW - Sexual behavior KW - Health risks KW - Prevention KW - Human immunodeficiency virus KW - Risk factors KW - Ethnic groups KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660405512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Correlates+of+Sexual+Risk+for+HIV+Among+US-Born+and+Foreign-Born+Latino+Men+Who+Have+Sex+with+Men+%28MSM%29%3A+An+Analysis+from+the+Brothers+y+Hermanos+Study&rft.au=Mizuno%2C+Yuko%3BBorkowf%2C+Craig+B%3BAyala%2C+George%3BCarballo-Dieguez%2C+Alex%3BMillett%2C+Gregorio+A&rft.aulast=Mizuno&rft.aufirst=Yuko&rft.date=2015-02-01&rft.volume=17&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-013-9894-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 35 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Risk assessment; Binge drinking; Immigrants; Discrimination; Homosexuality; Drug abuse; Sexual behavior; Substance use; Health risks; Prevention; Human immunodeficiency virus; Risk factors; Ethnic groups DO - http://dx.doi.org/10.1007/s10903-013-9894-5 ER - TY - JOUR T1 - Hypothesis On The Source, Transmission and Characteristics of Infection of Avian Influenza A (H7N9) Virus - Based On Analysis of Field Epidemiological Investigation and Gene Sequence Analysis AN - 1654674074; PQ0001032060 AB - On 31 March 2013, the National Health and Family Planning Commission announced that human infections with influenza A (H7N9) virus had occurred in Shanghai and Anhui provinces, China. H7N9 cases were later detected in Jiangsu and Zhejiang provinces. It was estimated that the virus first spread northward along the route taken by migratory birds and then spread to neighbouring provinces with the sale of poultry. Epidemiological studies were carried out on samples from the external environment of infected cases, transmission routes, farmers markets and live poultry markets. Phylogenetic study of viral sequences from human and avian infections in Zhejiang showed that those from Shanghai and Jiangsu provinces along Taihu Lake were highly homologous with those from the external environment. This suggests that avian viruses carried by waterfowl combined with the virus carried by migratory birds, giving rise to avian influenza virus H7N9, which is highly pathogenic to humans. It is possible that the virus was transmitted by local wildfowl to domestic poultry and then to humans, or spread further by means of trading in wholesale poultry markets. As the weather has turned warm, and with measures adopted to terminate poultry trade and facilitate health communication, the epidemic in the first half of the year has been kept under control. However, the infection source in the triangular area around Taihu Lake still remains. The H7N9 epidemic will probably hit the area later in the year and next spring when the migratory birds return and may even spread to other areas. Great importance should therefore be attached to the wildfowl in Taihu Lake as the repository and disseminator of the virus: investigation and study of this population is essential. JF - Zoonoses and Public Health AU - Ling, F AU - Chen, E AU - Liu, Q AU - Miao, Z AU - Gong, Z AD - Zhejiang Provincial Center for Disease Control and Prevention Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 29 EP - 37 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 1 SN - 1863-1959, 1863-1959 KW - Genetics Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Poultry KW - Avian influenza virus KW - Trade KW - Viruses KW - Communication KW - Infection KW - Disease transmission KW - Public health KW - Influenza KW - Lakes KW - China, People's Rep., Jiangsu KW - China, People's Rep., Tai Hu L. KW - Family planning KW - Phylogeny KW - Waterfowl KW - Weather KW - Epidemics KW - Recruitment KW - Population studies KW - Migratory birds KW - Fowl plague KW - Zoonoses KW - Communications KW - Commissions KW - China, People's Rep., Shanghai KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - G 07880:Human Genetics KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654674074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zoonoses+and+Public+Health&rft.atitle=Hypothesis+On+The+Source%2C+Transmission+and+Characteristics+of+Infection+of+Avian+Influenza+A+%28H7N9%29+Virus+-+Based+On+Analysis+of+Field+Epidemiological+Investigation+and+Gene+Sequence+Analysis&rft.au=Ling%2C+F%3BChen%2C+E%3BLiu%2C+Q%3BMiao%2C+Z%3BGong%2C+Z&rft.aulast=Ling&rft.aufirst=F&rft.date=2015-02-01&rft.volume=62&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Zoonoses+and+Public+Health&rft.issn=18631959&rft_id=info:doi/10.1111%2Fzph.12110 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Phylogeny; Weather; Poultry; Epidemics; Recruitment; Communication; Population studies; Infection; Public health; Disease transmission; Fowl plague; Lakes; Zoonoses; Family planning; Waterfowl; Trade; Viruses; Migratory birds; Influenza; Communications; Commissions; Avian influenza virus; China, People's Rep., Jiangsu; China, People's Rep., Tai Hu L.; China, People's Rep., Shanghai DO - http://dx.doi.org/10.1111/zph.12110 ER - TY - JOUR T1 - Tuberculosis incidence after 36 months' isoniazid prophylaxis in HIV-infected adults in Botswana: a posttrial observational analysis AN - 1808688689; PQ0003241686 AB - Objective: Thirty-six months of isoniazid preventive therapy (36IPT) was superior to 6 months of IPT (6IPT) in preventing tuberculosis (TB) among HIV-infected adults in Botswana. We assessed the posttrial durability of this benefit. Design: A 36-month double-blind placebo controlled trial (1:1 randomization) with recruitment between November 2004 and July 2006 and observation until June 2011. Methods: One thousand, nine hundred and ninety-five participants were followed in eight public health clinics. Twenty-four percent had a tuberculin skin test > or =5mm (TST-positive). A minimum CD4 super(+) lymphocyte count was not required for enrolment. Antiretroviral therapy (ART) was provided in accordance with Botswana guidelines; 72% of participants retained by June 2011 had initiated ART. Multivariable analysis using Cox regression analysis included treatment arm, TST status, ART as a time-dependent variable and CD4 super(+) cell count at baseline and updated at 36 months. Results: In the posttrial period, 2.13 and 2.14 per 100 person-years accumulated, whereas 0.93 and 1.13% TB incidence rates were observed in the 36IPT and 6IPT arms, respectively (P=0.52). The crude hazard ratio of TB during the trial and posttrial was 0.57 [95% confidence intervals (CI) 0.33, 0.99] and 0.82 (95% CI 0.46, 1.49), and when restricted to TST-positive participants was 0.26 (95% CI 0.08, 0.80) and 0.40 (95% CI 0.15, 1.08), respectively. Multivariable analysis showed that ART use was associated with reduced death (adjusted hazard ratio 0.36, 95% CI 0.17-0.75) but not TB (0.92, 95% CI 0.55-1.53) in the posttrial period. Conclusion: The benefit of 36IPT for TB prevention declined posttrial in this cohort. Adjunctive measures are warranted to prevent TB among HIV-infected persons receiving long-term ART in TB-endemic settings. JF - AIDS AU - Samandari, Taraz AU - Agizew, Tefera B AU - Nyirenda, Samba AU - Tedla, Zegabriel AU - Sibanda, Thabisa AU - Mosimaneotsile, Barudi AU - Motsamai I, Oaitse AU - Shang, Nong AU - Rose, Charles E AU - Shepherd, James AD - Centers for Disease Control and Prevention Botswana, Gaborone and Francistown, Botswana, tts0@cdc.gov Y1 - 2015/01/28/ PY - 2015 DA - 2015 Jan 28 SP - 351 EP - 359 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 29 IS - 3 SN - 0269-9370, 0269-9370 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - antiretroviral therapy KW - HIV KW - isoniazid KW - preventive therapy KW - tuberculin KW - tuberculosis KW - Acquired immune deficiency syndrome KW - Mycobacterium KW - Lymphocytes KW - Clinical trials KW - Public health KW - CD4 antigen KW - Regression analysis KW - Tuberculosis KW - Isoniazid KW - Mortality KW - Cell number KW - Guidelines KW - Recruitment KW - Antiretroviral agents KW - Skin tests KW - Prevention KW - Human immunodeficiency virus KW - Prophylaxis KW - Botswana KW - Tuberculin KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808688689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Tuberculosis+incidence+after+36+months%27+isoniazid+prophylaxis+in+HIV-infected+adults+in+Botswana%3A+a+posttrial+observational+analysis&rft.au=Samandari%2C+Taraz%3BAgizew%2C+Tefera+B%3BNyirenda%2C+Samba%3BTedla%2C+Zegabriel%3BSibanda%2C+Thabisa%3BMosimaneotsile%2C+Barudi%3BMotsamai+I%2C+Oaitse%3BShang%2C+Nong%3BRose%2C+Charles+E%3BShepherd%2C+James&rft.aulast=Samandari&rft.aufirst=Taraz&rft.date=2015-01-28&rft.volume=29&rft.issue=3&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000535 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Cell number; antiretroviral therapy; Regression analysis; Prophylaxis; Tuberculin; Tuberculosis; Skin tests; Public health; Isoniazid; Mortality; Prevention; Acquired immune deficiency syndrome; Recruitment; Guidelines; Lymphocytes; Clinical trials; Antiretroviral agents; Mycobacterium; Human immunodeficiency virus; Botswana DO - http://dx.doi.org/10.1097/QAD.0000000000000535 ER - TY - JOUR T1 - Characterization of Drug-Resistant Influenza A(H7N9) Variants Isolated From an Oseltamivir-Treated Patient in Taiwan AN - 1687690892; PQ0001568789 AB - Background Patients contracting influenza A(H7N9) infection often developed severe disease causing respiratory failure. Neuraminidase (NA) inhibitors (NAIs) are the primary option for treatment, but information on drug-resistance markers for influenza A(H7N9) is limited. Methods Four NA variants of A/Taiwan/1/2013(H7N9) virus containing a single substitution (NA-E119V, NA-I222K, NA-I222R, or NA-R292K) recovered from an oseltamivir-treated patient were tested for NAI susceptibility in vitro; their replicative fitness was evaluated in cell culture, mice, and ferrets. Results NA-R292K led to highly reduced inhibition by oseltamivir and peramivir, while NA-E119V, NA-I222K, and NA-I222R caused reduced inhibition by oseltamivir. Mice infected with any virus showed severe clinical signs with high mortality rates. NA-I222K virus was the most virulent in mice, whereas virus lacking NA change (NA-WT) and NA-R292K virus seemed the least virulent. Sequence analysis suggests that PB2-S714N increased virulence of NA-I222K virus in mice; NS1-K126R, alone or in combination with PB2-V227M, produced contrasting effects in NA-WT and NA-R292K viruses. In ferrets, all viruses replicated to high titers in the upper respiratory tract but produced only mild illness. NA-R292K virus, showed reduced replicative fitness in this animal model. Conclusions Our data highlight challenges in assessment of the replicative fitness of H7N9 NA variants that emerged in NAI-treated patients. JF - Journal of Infectious Diseases AU - Marjuki, Henju AU - Mishin, Vasiliy P AU - Chesnokov, Anton P AU - Jones, Joyce AU - De La Cruz, Juan A AU - Sleeman, Katrina AU - Tamura, Daisuke AU - Nguyen, Ha T AU - Wu, Ho-Sheng AU - Chang, Feng-Yee AD - Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 249 EP - 257 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 2 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - influenza virus KW - H7N9 KW - oseltamivir KW - peramivir KW - R292K KW - E119V KW - I222K KW - I222R KW - mice KW - ferrets KW - Fitness KW - Mortality KW - Data processing KW - Drug resistance KW - Viruses KW - Animal models KW - Mice KW - Cell culture KW - Infection KW - Oseltamivir KW - Influenza KW - Virulence KW - ISEW, Taiwan KW - Mustela KW - Infectious diseases KW - Exo- alpha -sialidase KW - Respiratory tract KW - V 22410:Animal Diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687690892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Characterization+of+Drug-Resistant+Influenza+A%28H7N9%29+Variants+Isolated+From+an+Oseltamivir-Treated+Patient+in+Taiwan&rft.au=Marjuki%2C+Henju%3BMishin%2C+Vasiliy+P%3BChesnokov%2C+Anton+P%3BJones%2C+Joyce%3BDe+La+Cruz%2C+Juan+A%3BSleeman%2C+Katrina%3BTamura%2C+Daisuke%3BNguyen%2C+Ha+T%3BWu%2C+Ho-Sheng%3BChang%2C+Feng-Yee&rft.aulast=Marjuki&rft.aufirst=Henju&rft.date=2015-01-15&rft.volume=211&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu447 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Virulence; Fitness; Influenza; Mortality; Data processing; Drug resistance; Animal models; Cell culture; Exo- alpha -sialidase; Infection; Respiratory tract; Oseltamivir; Infectious diseases; Viruses; Mice; Mustela; ISEW, Taiwan DO - http://dx.doi.org/10.1093/infdis/jiu447 ER - TY - JOUR T1 - ORAL SHEDDING OF MARBURG VIRUS IN EXPERIMENTALLY INFECTED EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS) AN - 1837336482; PQ0003751748 AB - Marburg virus (Marburg marburgvirus; MARV) causes sporadic outbreaks of Marburg hemorrhagic fever (MHF) in Africa. The Egyptian fruit bat (Rousettus aegyptiacus) has been identified as a natural reservoir based most-recently on the repeated isolation of MARV directly from bats caught at two locations in southwestern Uganda where miners and tourists separately contracted MHF from 2007-08. Despite learning much about the ecology of MARV through extensive field investigations, there remained unanswered questions such as determining the primary routes of virus shedding and the severity of disease, if any, caused by MARV in infected bats. To answer these questions and others, we experimentally infected captive-bred R. aegyptiacus with MARV under high (biosafety level 4) containment. These experiments have shown infection profiles consistent with R. aegyptiacus being a bona fide natural reservoir host for MARV and demonstrated routes of viral shedding capable of infecting humans and other animals. JF - Journal of Wildlife Diseases AU - Amman, Brian R AU - Jones, Megan E B AU - Sealy, Tara K AU - Uebelhoer, Luke S AU - Schuh, Amy J AU - Bird, Brian H AU - Coleman-Mccray, Joann D AU - Martin, Brock E AU - Nichol, Stuart T AU - Towner, Jonathan S AD - Centers for Disease Control and Prevention, Viral Special Pathogens Branch, 1600 Clifton Rd. NE, Atlanta, Georgia 30333, USA, jit8@cdc.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 113 EP - 124 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 United States VL - 51 IS - 1 SN - 0090-3558, 0090-3558 KW - Virology & AIDS Abstracts; Ecology Abstracts KW - Experimental infection KW - Marburg virus KW - Rousettus aegyptiacus KW - shedding KW - transmission KW - Fruits KW - Learning KW - Hemorrhagic fever KW - Infection KW - Marburgvirus KW - V 22410:Animal Diseases KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837336482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Wildlife+Diseases&rft.atitle=ORAL+SHEDDING+OF+MARBURG+VIRUS+IN+EXPERIMENTALLY+INFECTED+EGYPTIAN+FRUIT+BATS+%28ROUSETTUS+AEGYPTIACUS%29&rft.au=Amman%2C+Brian+R%3BJones%2C+Megan+E+B%3BSealy%2C+Tara+K%3BUebelhoer%2C+Luke+S%3BSchuh%2C+Amy+J%3BBird%2C+Brian+H%3BColeman-Mccray%2C+Joann+D%3BMartin%2C+Brock+E%3BNichol%2C+Stuart+T%3BTowner%2C+Jonathan+S&rft.aulast=Amman&rft.aufirst=Brian&rft.date=2015-01-01&rft.volume=51&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Journal+of+Wildlife+Diseases&rft.issn=00903558&rft_id=info:doi/10.7589%2F2014-08-198 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-09 N1 - SubjectsTermNotLitGenreText - Fruits; Learning; Hemorrhagic fever; Infection; Marburgvirus DO - http://dx.doi.org/10.7589/2014-08-198 ER - TY - JOUR T1 - Genetic characterazation of influenza A H3N2 and H7N9 viruses in a mixed infection case in Nanjing, 2013 AN - 1811891381; PQ0003526816 AB - [Objective] To analysis the molecular genetic characteristics of influenza A virus H3N2 and N7N9 viruses in one case of mixed infection. [Methods] Using a set of primers and probes for influenza virus genotyping, specimens were detected by real-time quantitative PCR method. Whole-genome sequences of virus isolates were obtained by second-generation sequencing technology. [Results] In April 2013, one mixed infection with seasonal H3N2 influenza virus and avian influenza H7N9 virus were confirmed in Nanjing, and two mixed viruses were isolated, which named A/Nanjing/M1/2013(H3N2)(M1-H3N2) and A/Nanjing/M2/2013(H7N9)(M2-H7N9), respectively. Some important molecular markers associated with host adaptation and virulence were identified in M2-H7N9 virus. M2-H7N9 virus had substitution Q226L(H3 numbering) in the receptor-binding site of hemagglutinin, which may facilitate the viruses to bind to sialic acid(SA)-2,6-Gal-terminated saccharides that are abundant in human upper respiratory epithelium. There was substitution at position 627(E arrow right K) in the PB2 protein, which enhances the ability of the virus infection on the human. [Conclusion] This study provided a direct evidence for human as "mix vessel" of influenza virus, and the reassortment of seasonal influenza viruses and avian H7N9 viruses should be concerned. JF - Microbiology/Weishengwuxue Tongbao AU - Du, Xue-Fei AU - Ding, Jie AU - Qi, Xian AU - Cui, Lun-Biao AU - Shi, Li-Min AD - Nanjing Center for Disease Control and Prevention Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 1788 EP - 1794 PB - Kexue Chubanshe, 16 Donghuang Cheng Genbei Jie Beijing 100717 China VL - 42 IS - 9 SN - 0253-2654, 0253-2654 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Influenza A virus KW - Mixed infection KW - H3N2 subtype KW - H7N9 subtype KW - Adaptations KW - Influenza A KW - Hemagglutinins KW - Genotyping KW - Probes KW - Virulence KW - Fowl plague KW - Polymerase chain reaction KW - Primers KW - Respiratory tract KW - V 22410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811891381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology%2FWeishengwuxue+Tongbao&rft.atitle=Genetic+characterazation+of+influenza+A+H3N2+and+H7N9+viruses+in+a+mixed+infection+case+in+Nanjing%2C+2013&rft.au=Du%2C+Xue-Fei%3BDing%2C+Jie%3BQi%2C+Xian%3BCui%2C+Lun-Biao%3BShi%2C+Li-Min&rft.aulast=Du&rft.aufirst=Xue-Fei&rft.date=2015-01-01&rft.volume=42&rft.issue=9&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Microbiology%2FWeishengwuxue+Tongbao&rft.issn=02532654&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Virulence; Fowl plague; Adaptations; Genotyping; Hemagglutinins; Influenza A; Probes; Polymerase chain reaction; Primers; Respiratory tract; Mixed infection; Influenza A virus ER - TY - JOUR T1 - Current and Emerging Legionella Diagnostics for Laboratory and Outbreak Investigations AN - 1753503086; 21328222 JF - Clinical Microbiology Reviews AU - Mercante, Jeffrey W AU - Winchell, Jonas M PY - 2015 SP - 95 EP - 133 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 28 IS - 1 SN - 0893-8512, 0893-8512 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753503086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Current+and+Emerging+Legionella+Diagnostics+for+Laboratory+and+Outbreak+Investigations&rft.au=Mercante%2C+Jeffrey+W%3BWinchell%2C+Jonas+M&rft.aulast=Mercante&rft.aufirst=Jeffrey&rft.date=2015-01-01&rft.volume=28&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/10.1128%2FCMR.00029-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Number of references - 595 N1 - Last updated - 2016-01-06 DO - http://dx.doi.org/10.1128/CMR.00029-14 ER - TY - JOUR T1 - HIV epidemic among drug users in China: 1995-2011 AN - 1752989979; 2011-896175 AB - To describe trends in the HIV epidemic among drug users (DUs) in China from 1995 to 2011. Data sets from China's national HIV/AIDS case reporting and sentinel surveillance systems as of December 2011 were used separately for descriptive analysis. Changes in the geographic distribution of the number of HIV cases and HIV prevalence among injecting drug users (IDUs) and non-IDUs were examined. We also analysed changes in HIV prevalence among the broader DU population, and drug use-related behaviours including types of drugs used, recent injecting and recent needle sharing in the context of the rapid scale-up of DU sentinel sites and national harm reduction programmes. The HIV epidemic among China's DUs is still highly concentrated in five provinces. Here, HIV prevalence peaked at 30.3% [95% confidence interval (CI) = 28.6, 32.1] among IDUs in 1999, and then gradually decreased to 10.9% (95% CI = 10.6, 11.2) by 2011. We observed a rapid increase in the use of 'nightclub drugs' among DUs from 1.3% in 2004 to 24.4% in 2011. A decline in recent needle sharing among current IDU from 19.5% (95% CI = 19.4, 19.6) in 2006 to 11.3% (95% CI = 11.2, 11.4) in 2011 was found to be correlated with the rapid scale-up of methadone maintenance treatment (MMT; r(4) = -0.94, P = 0.003) harm reduction efforts. While HIV prevalence and needle sharing among current injecting drug users in China have declined dramatically and are correlated with the scale-up of national harm reduction efforts, the recent, rapid increased use of 'nightclub drugs' presents a new challenge. Adapted from the source document. JF - Addiction AU - Wang, Lan AU - Guo, Wei AU - Li, Dongmin AU - Ding, Zhengwei AU - McGoogan, Jennifer M AU - Wang, Ning AU - Wu, Zunyou AU - Wang, Lu AD - National Center for AIDS/STD Control and Prevention. Chinese Center for Disease Control and Prevention Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 20 EP - 28 PB - Blackwell Publishing, Oxford UK VL - 110 IS - s1 SN - 0965-2140, 0965-2140 KW - Human immunodeficiency virus KW - Population KW - China (People's Republic) KW - Drugs KW - Surveillance KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752989979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=HIV+epidemic+among+drug+users+in+China%3A+1995-2011&rft.au=Wang%2C+Lan%3BGuo%2C+Wei%3BLi%2C+Dongmin%3BDing%2C+Zhengwei%3BMcGoogan%2C+Jennifer+M%3BWang%2C+Ning%3BWu%2C+Zunyou%3BWang%2C+Lu&rft.aulast=Wang&rft.aufirst=Lan&rft.date=2015-01-01&rft.volume=110&rft.issue=s1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12779 LA - English DB - PAIS Index N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Drugs; China (People's Republic); Population; Surveillance DO - http://dx.doi.org/10.1111/add.12779 ER - TY - JOUR T1 - Who uses methadone services in China? Monitoring the world's largest methadone programme AN - 1752989936; 2011-896176 AB - To describe the data collected by the Chinese methadone maintenance treatment (MMT) system and the characteristics of clients entering the programme. Descriptive study using routinely collected data from the MMT data management system for the period March 2004 and March 2010. Clients who enrolled for services between March 2004 and March 2010. Routinely collected data included: demographic information; drug use, sexual and criminal behaviours; status of infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV) and syphilis; random urine-opiate test results; and the daily methadone dose received. Differences among clients by year were examined. During the period examined, there were 251 974 clients attending 684 clinics in 27 provinces. Overall, the mean age was 34.4 years, 83.8% were male, 70.2% were unemployed, 75% had ever injected drugs, 17% had shared needles and 7.4% were HIV-positive. The profile of clients changed over time, with fewer HIV-positive individuals, fewer injecting drug users, fewer needle-sharers, fewer females and fewer unemployed. Half the clients dropped out within 6 months. The average final dose received was 49.4 mg. The estimated probability of interrupting treatment before 6 months was 52.5%. The profile of clients enrolling in methadone maintenance treatment in China is continually changing and appears to be associated with reduced risk of HIV. High dropout in the programme may limit its effectiveness. The availability of a centralized, real-time data system was extremely useful for monitoring the progress of the Chinese methadone maintenance treatment programme. Adapted from the source document. JF - Addiction AU - Sullivan, Sheena G AU - Wu, Zunyou AU - Rou, Keming AU - Pang, Lin AU - Luo, Wei AU - Wang, Changhe AU - Cao, Xiaobin AU - Yin, Wenyuan AU - Liu, Enwu AU - Mi, Guodong AD - National Center for AIDS/STD Control and Prevention. Chinese Center for Disease Control and Prevention Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 29 EP - 39 PB - Blackwell Publishing, Oxford UK VL - 110 IS - s1 SN - 0965-2140, 0965-2140 KW - Hepatitis KW - Risk KW - Unemployment KW - Human immunodeficiency virus KW - Clinics KW - Syphilis KW - China (People's Republic) KW - Drugs KW - Demographics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752989936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Who+uses+methadone+services+in+China%3F+Monitoring+the+world%27s+largest+methadone+programme&rft.au=Sullivan%2C+Sheena+G%3BWu%2C+Zunyou%3BRou%2C+Keming%3BPang%2C+Lin%3BLuo%2C+Wei%3BWang%2C+Changhe%3BCao%2C+Xiaobin%3BYin%2C+Wenyuan%3BLiu%2C+Enwu%3BMi%2C+Guodong&rft.aulast=Sullivan&rft.aufirst=Sheena&rft.date=2015-01-01&rft.volume=110&rft.issue=s1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12781 LA - English DB - PAIS Index N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Drugs; Unemployment; China (People's Republic); Clinics; Demographics; Syphilis; Hepatitis; Risk DO - http://dx.doi.org/10.1111/add.12781 ER - TY - JOUR T1 - Needle and syringe exchange programmes and prevalence of HIV infection among intravenous drug users in China AN - 1752989898; 2011-896180 AB - To examine the association between needle and syringe exchange programme (NSEP) participation and human immunodeficiency virus (HIV) infection among intravenous drug users (IDUs) in China. Six counties with active NSEP were selected from each of the seven provinces with active NSEP sampled, resulting in a sample of 42 counties in China. Subjects were aged more than 18 years and had injected drugs in the past month before the survey, but were excluded if they were currently enrolled in methadone maintenance treatment in order to avoid mixed effects. HIV prevalence was the primary measure. Odds ratios (ORs), 95% confidence intervals (CIs) and P-values were calculated to evaluate associations between HIV infection and NSEP participation. A total of 3494 IDUs were interviewed, of whom 1928 (55.2%) were NSEP attendees (meaning they had attended NSEP at least once in their life-time). The unadjusted HIV prevalence was 13.9% among NSEP attendees and 16.5% among NSEP non-attendees (meaning IDUs who had never used NSEP services). After adjusting for potential confounders and taking into account the variation between counties, NSEP non-attendees were 1.67 times more likely to be HIV-positive compared to NSEP attendees (OR = 1.67, CI = 1.19-2.32, P = 0.0031). Participation in needle and syringe exchange programmes was associated with a substantially lower risk of HIV infection among intravenous drug users in China. Needle and syringe exchange programmes should be expanded to include those who are needle and syringe exchange programme non-attendees. Adapted from the source document. JF - Addiction AU - Luo, Wei AU - Wu, Zunyou AU - Poundstone, Katharine AU - McGoogan, Jennifer M AU - Dong, Willa AU - Pang, Lin AU - Rou, Keming AU - Wang, Changhe AU - Cao, Xiaobin AD - National Center for AIDS/STD Control and Prevention. Chinese Center for Disease Control and Prevention Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 61 EP - 67 PB - Blackwell Publishing, Oxford UK VL - 110 IS - s1 SN - 0965-2140, 0965-2140 KW - Risk KW - Human immunodeficiency virus KW - Associations KW - Surveys KW - Drugs KW - China (People's Republic) KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752989898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Needle+and+syringe+exchange+programmes+and+prevalence+of+HIV+infection+among+intravenous+drug+users+in+China&rft.au=Luo%2C+Wei%3BWu%2C+Zunyou%3BPoundstone%2C+Katharine%3BMcGoogan%2C+Jennifer+M%3BDong%2C+Willa%3BPang%2C+Lin%3BRou%2C+Keming%3BWang%2C+Changhe%3BCao%2C+Xiaobin&rft.aulast=Luo&rft.aufirst=Wei&rft.date=2015-01-01&rft.volume=110&rft.issue=s1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12783 LA - English DB - PAIS Index N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; China (People's Republic); Drugs; Associations; Risk; Surveys DO - http://dx.doi.org/10.1111/add.12783 ER - TY - JOUR T1 - Evaluation of Selected Borrelia burgdorferi lp54 Plasmid-Encoded Gene Products Expressed during Mammalian Infection as Antigens To Improve Serodiagnostic Testing for Early Lyme Disease AN - 1746893584; PQ0002295838 AB - Laboratory testing for the diagnosis of Lyme disease is performed primarily by serologic assays and is accurate for detection beyond the acute stage of the infection. Serodiagnostic assays to detect the early stages of infection, however, are limited in their sensitivity, and improvement is warranted. We analyzed a series of Borrelia burgdorferi proteins known to be induced within feeding ticks and/or during mammalian infection for their utility as serodiagnostic markers against a comprehensive panel of Lyme disease patient serum samples. The antigens were assayed for IgM and IgG reactivity in line immunoblots and separately by enzyme-linked immunosorbent assay (ELISA), with a focus on reactivity against early Lyme disease with erythema migrans (EM), early disseminated Lyme neuroborreliosis, and early Lyme carditis patient serum samples. By IgM immunoblotting, we found that recombinant proteins BBA65, BBA70, and BBA73 reacted with early Lyme EM samples at levels comparable to those of the OspC antigen used in the current IgM blotting criteria. Additionally, these proteins reacted with serum samples from patients with early neuroborreliosis and early carditis, suggesting value in detecting early stages of this disease progression. We also found serological reactivity against recombinant proteins BBA69 and BBA73 with early-Lyme-disease samples using IgG immunoblotting and ELISA. Significantly, some samples that had been scored negative by the Centers for Disease Control and Prevention-recommended 2-tiered testing algorithm demonstrated positive reactivity to one or more of the antigens by IgM/IgG immunoblot and ELISA. These results suggest that incorporating additional in vivo-expressed antigens into the current IgM/IgG immunoblotting tier in a recombinant protein platform assay may improve the performance of early-Lyme-disease serologic testing. JF - Clinical and Vaccine Immunology AU - Weiner, Zachary P AU - Crew, Rebecca M AU - Brandt, Kevin S AU - Ullmann, Amy J AU - Schriefer, Martin E AU - Molins, Claudia R AU - Gilmore, Robert D PY - 2015 SP - 1176 EP - 1186 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 22 IS - 11 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746893584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Evaluation+of+Selected+Borrelia+burgdorferi+lp54+Plasmid-Encoded+Gene+Products+Expressed+during+Mammalian+Infection+as+Antigens+To+Improve+Serodiagnostic+Testing+for+Early+Lyme+Disease&rft.au=Weiner%2C+Zachary+P%3BCrew%2C+Rebecca+M%3BBrandt%2C+Kevin+S%3BUllmann%2C+Amy+J%3BSchriefer%2C+Martin+E%3BMolins%2C+Claudia+R%3BGilmore%2C+Robert+D&rft.aulast=Weiner&rft.aufirst=Zachary&rft.date=2015-01-01&rft.volume=22&rft.issue=11&rft.spage=1176&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00399-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 40 N1 - Last updated - 2015-12-23 DO - http://dx.doi.org/10.1128/CVI.00399-15 ER - TY - JOUR T1 - Indirect cohort analysis of 10-valent pneumococcal conjugate vaccine effectiveness against vaccine-type and vaccine-related invasive pneumococcal disease AN - 1746889459; PQ0002312874 AB - We applied the indirect cohort method to estimate effectiveness of 10-valent pneumococcal conjugate vaccine (PCV10) among young children in Brazil. Cases of invasive pneumococcal disease (IPD), i.e., Streptococcus pneumoniae, detected in normally sterile fluid identified through laboratory-based surveillance and previously enrolled in a matched case-control effectiveness study are included. We estimated PCV10 effectiveness using multivariable logistic regression comparing PCV10 vaccination among children with vaccine-type or vaccine-related IPD vs. children with non-vaccine-type disease. The adjusted effectiveness of greater than or equal to 1 doses against vaccine-type (72.8%, 95% confidence interval [CI] [44.1, 86.7]) and vaccine-related (61.3%, 95%CI [14.5, 82.5]) IPD were similar to the effectiveness observed in the original case-control study (which required enrollment >1200 controls). We also found significant protection of greater than or equal to 1 dose against individual vaccine serotypes (14, 6B, 23F, 18C) and against vaccine-related serotype 19A. The indirect cohort methods leverages existing surveillance is a feasible approach for evaluating pneumococcal conjugate vaccines, particularly in resource-limited settings. JF - Vaccine AU - Verani, Jennifer R AU - Domingues, Carla Magda ASantos AU - Moraes, Jose Cassio de AD - National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia PY - 2015 SP - 6145 EP - 6148 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 33 IS - 46 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Pneumococcal conjugate vaccine (PCV) KW - Invasive pneumococcal disease (IPD) KW - Vaccine effectiveness KW - Brazil KW - Case-control studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746889459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Indirect+cohort+analysis+of+10-valent+pneumococcal+conjugate+vaccine+effectiveness+against+vaccine-type+and+vaccine-related+invasive+pneumococcal+disease&rft.au=Verani%2C+Jennifer+R%3BDomingues%2C+Carla+Magda+ASantos%3BMoraes%2C+Jose+Cassio+de&rft.aulast=Verani&rft.aufirst=Jennifer&rft.date=2015-01-01&rft.volume=33&rft.issue=46&rft.spage=6145&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2015.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 12 N1 - Last updated - 2015-12-23 DO - http://dx.doi.org/10.1016/j.vaccine.2015.10.007 ER - TY - JOUR T1 - Reduced Sexual Risk Behaviors Among Young Men of Color Who Have Sex with Men: Findings from the Community-Based Organization Behavioral Outcomes of Many Men, Many Voices (CBOP-3MV) Project AN - 1732839235; PQ0002250243 AB - In 2006, the Centers for Disease Control and Prevention (CDC) funded community-based organizations (CBOs) to deliver Many Men, Many Voices (3MV) to young men of color who have sex with men. Although 3MV, a group-level behavioral intervention designed to reduce human immunodeficiency virus (HIV) risk behaviors of black men who have sex with men (MSM), has shown effectiveness when delivered in a controlled research environment, there is limited evidence that the intervention is associated with similar outcomes in "real world" settings. For the current project, CDC funded three CBOs to conduct outcome monitoring of the 3MV intervention to determine if young MSM of color report changes in HIV risk behaviors postintervention. Using a repeated measures design, risk behaviors were collected at baseline and again at 3 and 6 months postintervention. Changes in risk behaviors were assessed using generalized estimating equations. Participants (n=337) reported decreases in sexual risk behaviors at both follow-up time points, such as sex without a condom, sex without a condom and multiple partners, and sex without a condom with serodiscordant or status unknown partners. Results suggest that 3MV may be an effective tool for reducing HIV risk behaviors in this critical target population. JF - Prevention Science AU - Stein, Renee AU - Shapatava, Ekaterine AU - Williams, Weston AU - Griffin, Tanesha AU - Bell, Kelly AU - Lyons, Bridget AU - Uhl, Gary AD - Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS-E59, Atlanta, GA, 30333, USA, arf7@cdc.gov PY - 2015 SP - 1147 EP - 1158 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 16 IS - 8 SN - 1389-4986, 1389-4986 KW - Risk Abstracts KW - Risk assessment KW - Community involvement KW - Males KW - Disease control KW - Risk taking KW - Intervention KW - Homosexuality KW - Sexual behavior KW - Condoms KW - Currents KW - Prevention KW - Behavior KW - Human immunodeficiency virus KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732839235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prevention+Science&rft.atitle=Reduced+Sexual+Risk+Behaviors+Among+Young+Men+of+Color+Who+Have+Sex+with+Men%3A+Findings+from+the+Community-Based+Organization+Behavioral+Outcomes+of+Many+Men%2C+Many+Voices+%28CBOP-3MV%29+Project&rft.au=Stein%2C+Renee%3BShapatava%2C+Ekaterine%3BWilliams%2C+Weston%3BGriffin%2C+Tanesha%3BBell%2C+Kelly%3BLyons%2C+Bridget%3BUhl%2C+Gary&rft.aulast=Stein&rft.aufirst=Renee&rft.date=2015-01-01&rft.volume=16&rft.issue=8&rft.spage=1147&rft.isbn=&rft.btitle=&rft.title=Prevention+Science&rft.issn=13894986&rft_id=info:doi/10.1007%2Fs11121-015-0565-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 20 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Risk assessment; Males; Community involvement; Disease control; Intervention; Risk taking; Homosexuality; Sexual behavior; Condoms; Prevention; Currents; Behavior; Human immunodeficiency virus DO - http://dx.doi.org/10.1007/s11121-015-0565-8 ER - TY - JOUR T1 - Epidemic characteristics of public health emergencies of infectious diseases in schools in Henan Province, 2013 AN - 1732813214; PQ0002133029 AB - To analyze the characteristics of public health emergencies of infectious diseases in schools in Henan Province, 2013, in order to provide the evidences for making preventive and control strategies. Descriptive epidemiological method was used to analyze the characteristics of public health emergencies of infectious diseases in schools in Henan Province, 2013. Software PHGIS 1.7.0 was applied to make the regional distribution map of the events. Kruskal-Wallis test was utilized to compare the duration for different categories of infectious diseases and the investigation time for health departments. Fifteen infectious diseases emergency events were reported in Henan Province, 2013, among which, 13 events were respiratory infectious diseases, and 2 events were intestinal diseases. A total of 17 170 people were affected, and there were 308 patients, but no patients died, and the attack rate was 1.79%. All the events were distributed in 14 counties of 9 cities. JF - Zhengzhou Daxue Xuebao (Yixue Ban) - Journal of Zhengzhou University. Medical sciences AU - You, Aiguo AU - Yang, Jianhua AU - Zhao, Xiaojing AU - Pan, Jingjing AU - Su, Jia AD - Institute for Infectious Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, youaiguo11@126.com PY - 2015 SP - 347 EP - 350 PB - Zhengzhou Daxue VL - 50 IS - 3 SN - 1671-6825, 1671-6825 KW - Health & Safety Science Abstracts KW - infectious disease KW - public health emergency KW - epidemic characteristic KW - school health KW - health emergency KW - Henan Province KW - Cities KW - Computer programs KW - Schools KW - Infectious diseases KW - Public health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732813214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhengzhou+Daxue+Xuebao+%28Yixue+Ban%29+-+Journal+of+Zhengzhou+University.+Medical+sciences&rft.atitle=Epidemic+characteristics+of+public+health+emergencies+of+infectious+diseases+in+schools+in+Henan+Province%2C+2013&rft.au=You%2C+Aiguo%3BYang%2C+Jianhua%3BZhao%2C+Xiaojing%3BPan%2C+Jingjing%3BSu%2C+Jia&rft.aulast=You&rft.aufirst=Aiguo&rft.date=2015-01-01&rft.volume=50&rft.issue=3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Zhengzhou+Daxue+Xuebao+%28Yixue+Ban%29+-+Journal+of+Zhengzhou+University.+Medical+sciences&rft.issn=16716825&rft_id=info:doi/10.13705%2Fj.issn.1671-6825.2015.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Computer programs; Cities; Schools; Infectious diseases; Public health DO - http://dx.doi.org/10.13705/j.issn.1671-6825.2015.03.010 ER - TY - JOUR T1 - Environmental Surveillance for Toxigenic Vibrio cholerae in Surface Waters of Haiti AN - 1722164907; PQ0002059453 AB - Epidemic cholera was reported in Haiti in 2010, with no information available on the occurrence or geographic distribution of toxigenic Vibrio cholerae in Haitian waters. In a series of field visits conducted in Haiti between 2011 and 2013, water and plankton samples were collected at 19 sites. Vibrio cholerae was detected using culture, polymerase chain reaction, and direct viable count methods (DFA-DVC). Cholera toxin genes were detected by polymerase chain reaction in broth enrichments of samples collected in all visits except March 2012. Toxigenic V. cholerae was isolated from river water in 2011 and 2013. Whole genome sequencing revealed that these isolates were a match to the outbreak strain. The DFA-DVC tests were positive for V. cholerae O1 in plankton samples collected from multiple sites. Results of this survey show that toxigenic V. cholerae could be recovered from surface waters in Haiti more than 2 years after the onset of the epidemic. JF - American Journal of Tropical Medicine and Hygiene AU - Kahler, Amy M AU - Haley, Bradd J AU - Chen, Arlene AU - Mull, Bonnie J AU - Tarr, Cheryl L AU - Turnsek, Maryann AU - Katz, Lee S AU - Humphrys, Michael S AU - Derado, Gordana AU - Freeman, Nicole AU - Boncy, Jacques AU - Colwell, Rita R AU - Huq, Anwar AU - Hill, Vincent R AD - Centers for Disease Control and Prevention, Atlanta, Georgia, vhill@cdc.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 118 EP - 125 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 1 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Genomes KW - Rivers KW - Geographical distribution KW - Epidemics KW - Pathogenic bacteria KW - Toxicants KW - Surface water KW - Nucleotide sequence KW - Bacterial diseases KW - Vibrio cholerae KW - Cholera toxin KW - Polymerase chain reaction KW - Cholera KW - Disease detection KW - Hygiene KW - Plankton KW - ASW, Caribbean Sea, Greater Antilles, Haiti KW - Q1 08604:Stock assessment and management KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Environmental+Surveillance+for+Toxigenic+Vibrio+cholerae+in+Surface+Waters+of+Haiti&rft.au=Kahler%2C+Amy+M%3BHaley%2C+Bradd+J%3BChen%2C+Arlene%3BMull%2C+Bonnie+J%3BTarr%2C+Cheryl+L%3BTurnsek%2C+Maryann%3BKatz%2C+Lee+S%3BHumphrys%2C+Michael+S%3BDerado%2C+Gordana%3BFreeman%2C+Nicole%3BBoncy%2C+Jacques%3BColwell%2C+Rita+R%3BHuq%2C+Anwar%3BHill%2C+Vincent+R&rft.aulast=Kahler&rft.aufirst=Amy&rft.date=2015-01-01&rft.volume=92&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0601 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Epidemics; Toxicants; Pathogenic bacteria; Nucleotide sequence; Bacterial diseases; Polymerase chain reaction; Disease detection; Hygiene; Rivers; Genomes; Cholera toxin; Surface water; Cholera; Plankton; Vibrio cholerae; ASW, Caribbean Sea, Greater Antilles, Haiti DO - http://dx.doi.org/10.4269/ajtmh.13-0601 ER - TY - JOUR T1 - Virological Surveillance and Analysis on the Characteristics of HA1 Gene of Influenza a Virus H1N1, Case study of Xinyu City from 2013 to 2014 AN - 1676363320; PQ0001405574 AB - Due to head heavy chain region (HA1) of the HA gene are antigenic sites and receptor binding sites of influenza virus. To understand the characteristics of HA1 genes of influenza virus that can evaluate the preventive effect of the current vaccine strain recommend by WHO. 12 strains of influenza A virus H1N1 isolated in Xinyu from 2013 to 2014 were cultured in MDCK cell in this article. Viral RNA were extracted and HA1 gene were amplified by using RT-PCR. The nucleotide sequences were determined and analyzed. The results showed that there was high homology of HA1 between influenza A virus H1N1 isolates from Xinyu City from 2013 to 2014 and the vaccine strain recommended by WHO, the identity were 97.9% similar to 98.5% in nucleotides sequence. Between 6 strains of influenza A virus H1N1 isolated in Xinyu from 2013 and vaccine strain, 7 similar to 11 amino acids changed, 2 mutated sites of 3 strains in different antigenic determinant sites. The strains from 2014 existed in a branch of the evolutionary tree. The above prompted that the vaccine produced by influenza a virus H1N1 vaccine strain recommended by WHO had protective effect to H1N1 of 2014, had terminate protective effect to part of influenza H1N1 in 2013. The outbreak of influenza H1N1 is possible. We should strengthen prevention and control. JF - Jiyinzuxue yu Yingyong Shengwuxue / Genomics And Applied Biology AU - Pan, Hong AU - Liu, Ruihong AU - Wen, Qi AU - Liu, Qin AU - Zhou, Yingu AU - Xiong, Ying AD - Xinyu Center for Disease Control and Prevention, Xinyu, 338000, meihuayu90@163.com Y1 - 2015 PY - 2015 DA - 2015 SP - 247 EP - 251 PB - Genomics and Applied Biology, Room 111, Editorial office of Genomics and Applied Biology No. 100 Daxue East Road, Nanning City, Guangxi China VL - 34 IS - 2 SN - 1674-568X, 1674-568X KW - Genetics Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Influenza H1N1 virus |a MeSH KW - Hemagglutinin gene |a MeSH KW - Phylogenetic analysis |a MeSH KW - Amino acids KW - Trees KW - Nucleotide sequence KW - Influenza KW - HA1 gene KW - Prevention KW - Case studies KW - Homology KW - RNA KW - Branches KW - Influenza A virus KW - Antigenic determinants KW - Polymerase chain reaction KW - Outbreaks KW - Vaccines KW - Evolution KW - Urban areas KW - G 07760:Viruses & Phages KW - H 4000:Food and Drugs KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676363320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Jiyinzuxue+yu+Yingyong+Shengwuxue+%2F+Genomics+And+Applied+Biology&rft.atitle=Virological+Surveillance+and+Analysis+on+the+Characteristics+of+HA1+Gene+of+Influenza+a+Virus+H1N1%2C+Case+study+of+Xinyu+City+from+2013+to+2014&rft.au=Pan%2C+Hong%3BLiu%2C+Ruihong%3BWen%2C+Qi%3BLiu%2C+Qin%3BZhou%2C+Yingu%3BXiong%2C+Ying&rft.aulast=Pan&rft.aufirst=Hong&rft.date=2015-01-01&rft.volume=34&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Jiyinzuxue+yu+Yingyong+Shengwuxue+%2F+Genomics+And+Applied+Biology&rft.issn=1674568X&rft_id=info:doi/10.13417%2Fj.gab.034.000247 LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - HA1 gene; Amino acids; Branches; RNA; Homology; Nucleotide sequence; Antigenic determinants; Polymerase chain reaction; Vaccines; Evolution; Influenza; Prevention; Case studies; Trees; Outbreaks; Urban areas; Influenza A virus DO - http://dx.doi.org/10.13417/j.gab.034.000247 ER - TY - JOUR T1 - Effect of levofloxacin combining with capreomycin on immune function and liver function of patients with multidrug-resistant tuberculosis AN - 1668259920; PQ0001301252 AB - Objective: To study the effect of levofloxacin combining with capreomycin on immune function and liver function of patients with multidrug-resistant tuberculosis. Methods: 90 patients with multidrug-resistant tuberculosis in our hospital were enrolled and randomly divided into observation group and control group. The observation group received levofloxacin, capreomycin combining with conventional chemotherapy, control group received conventional chemotherapy. Then sputum negative conversion, immune function and liver function index were compared. Results: After treatment, observation group sputum negative conversion rate was significantly higher than control group; CD4 super(+) T cells and IgA, IgG, IgM contents were significantly higher than those of control group; CD8 super(+) T cells was significantly lower than that of control group. No significant differences in serum ALP, ALT, AST, STB, total protein levels were found between two groups. Conclusion: Levofloxacin combining with capreomycin treatment is helpful to kill Mycobacterium tuberculosis, improve immune function and will not increase the burden of liver; it's an ideal method in treating multidrug-resistant tuberculosis. JF - Journal of Hainan Medical University AU - LIU, Jun AU - ZHOU, Rong-zhong AD - Emergency Department, Hubei Provincial Center for Disease Control and Prevention Zaoyang 441200, liujunjzk@163.com Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 38 EP - 40 PB - Editorial Board of Journal of Hainan Medical College, Xueyuan Road Haikou Hainan 571101 China VL - 21 IS - 1 SN - 1007-1237, 1007-1237 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Multidrug-resistant tuberculosis KW - Levofloxacin KW - Capreomycin KW - Immune function KW - Liver function KW - Chemotherapy KW - Drug resistance KW - CD8 antigen KW - CD4 antigen KW - Immunoglobulin A KW - Lymphocytes T KW - Liver KW - Immunoglobulin G KW - Tuberculosis KW - Sputum KW - Immune response KW - Immunoglobulin M KW - Mycobacterium tuberculosis KW - Hospitals KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668259920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hainan+Medical+University&rft.atitle=Effect+of+levofloxacin+combining+with+capreomycin+on+immune+function+and+liver+function+of+patients+with+multidrug-resistant+tuberculosis&rft.au=LIU%2C+Jun%3BZHOU%2C+Rong-zhong&rft.aulast=LIU&rft.aufirst=Jun&rft.date=2015-01-01&rft.volume=21&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hainan+Medical+University&rft.issn=10071237&rft_id=info:doi/10.13210%2Fj.cnki.jhmu.20141028.013 LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Levofloxacin; Drug resistance; Chemotherapy; CD8 antigen; Immunoglobulin A; CD4 antigen; Capreomycin; Immunoglobulin G; Liver; Lymphocytes T; Tuberculosis; Immune response; Sputum; Immunoglobulin M; Hospitals; Mycobacterium tuberculosis DO - http://dx.doi.org/10.13210/j.cnki.jhmu.20141028.013 ER - TY - JOUR T1 - Prevalence and risk factors for stunting and severe stunting among children under three years old in mid‐western rural areas of China AN - 1665150927 AB - Adequate nutrition is needed to ensure optimum growth and development of infants and young children. Although the national economy has developed rapidly during recent decades in China, malnutrition continues to be a major public health problem. The aim of the present study was undertaken to assess the prevalence and risk factors associated with stunting and severe stunting under 3 years old in mid‐western rural areas in China. A community‐based cross‐sectional survey was carried out in 84 villages in mid‐western provinces of China in 2010. A total of 1260 children were selected for nutritional assessment in terms of stunting and severe stunting using the new World Health Organization growth standards. Hierarchical logistic regression was used to examine the risk factors for adverse nutritional status. The prevalence of stunting and severe stunting was 27.0% and 13.2% respectively. Hierarchical logistic regression analysis showed that the risk factors for stunted children were province of residence, caregiver's education, child's gender, low birthweight and duration of exclusive breastfeeding (<6 months). The risk factors for severe stunting in children aged 0–36 months were province of residence, caregiver's education and child's gender. These results indicate that malnutrition is still a major public health problem among children under 3 years old. The government should implement appropriate nutritional intervention strategies to help reduce the prevalence of malnutrition in children. JF - Child Care, Health and Development AU - Jiang, Y AU - Su, X AU - Wang, C AU - Zhang, L AU - Zhang, X AU - Wang, L AU - Cui, Y AD - National Management Center of 12320 Health Hotline. Chinese Center for Disease Control and Prevention ; National Management Center of 12320 Health Hotline. Chinese Center for Disease Control and Prevention Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 45 EP - 51 CY - Oxford PB - Wiley Subscription Services, Inc. VL - 41 IS - 1 SN - 0305-1862 KW - Medical Sciences--Pediatrics KW - Breastfeeding KW - Carers KW - Children KW - Gender KW - Health problems KW - Infants KW - Low birth weight KW - Malnutrition KW - Nutrition KW - Nutritional status KW - Provinces KW - Public health KW - Residence KW - Risk assessment KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665150927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Care%2C+Health+and+Development&rft.atitle=Prevalence+and+risk+factors+for+stunting+and+severe+stunting+among+children+under+three+years+old+in+mid%E2%80%90western+rural+areas+of+China&rft.au=Jiang%2C+Y%3BSu%2C+X%3BWang%2C+C%3BZhang%2C+L%3BZhang%2C+X%3BWang%2C+L%3BCui%2C+Y&rft.aulast=Jiang&rft.aufirst=Y&rft.date=2015-01-01&rft.volume=41&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Child+Care%2C+Health+and+Development&rft.issn=03051862&rft_id=info:doi/10.1111%2Fcch.12148 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2015-12-14 DO - http://dx.doi.org/10.1111/cch.12148 ER - TY - JOUR T1 - Investigations of Mycoplasma pneumoniae Infections in the United States: Trends in Molecular Typing and Macrolide Resistance from 2006 to 2013 AN - 1660389035; 21328480 AB - Mycoplasma pneumoniae is a leading cause of respiratory infections, including community-acquired pneumonia (CAP). Currently, pathogen-specific testing is not routinely performed in the primary care setting, and the United States lacks a systematic surveillance program for M. pneumoniae. Documentation of individual cases and clusters typically occurs only when severe illness and/or failure to improve with empirical antibiotic therapy is observed. Outbreaks, some lasting for extended periods and involving a large number of cases, occur regularly. However, many more likely go unrecognized due to the lack of diagnostic testing and structured reporting. We reviewed data from 17 investigations of cases, small clusters, and outbreaks of M. pneumoniae infections that were supported by the Centers for Disease Control and Prevention (CDC) between 2006 and 2013. We examined 199 M. pneumoniae-positive specimens collected during this time period in order to identify trends in antimicrobial resistance and circulating types. Overall, macrolide resistance was identified in approximately 10% of M. pneumoniae infections occurring during this time period. Typing of strains revealed cocirculation of multiple multilocus variable-number tandem-repeat analysis (MLVA) and P1 types throughout this period, including diversity in types detected within individual outbreaks. Three MLVA types (4572, 3562, and 3662) accounted for 97% of the infections during the study period. A systematic surveillance program is necessary to understand the burden of M. pneumoniae disease in the United States, facilitate case and outbreak identification, and inform appropriate therapeutic and infection control strategies. JF - Journal of Clinical Microbiology AU - Diaz, Maureen H AU - Benitez, Alvaro J AU - Winchell, Jonas M Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 124 EP - 130 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 1 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Typing KW - Data processing KW - Reviews KW - Drug resistance KW - Disease control KW - Antibiotics KW - Mycoplasma pneumoniae KW - Infection KW - Pneumonia KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660389035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Investigations+of+Mycoplasma+pneumoniae+Infections+in+the+United+States%3A+Trends+in+Molecular+Typing+and+Macrolide+Resistance+from+2006+to+2013&rft.au=Thompson%2C+Britta+M.%3BKnight%2C+Stephanie+L.&rft.aulast=Thompson&rft.aufirst=Britta&rft.date=2006-01-01&rft.volume=38&rft.issue=1&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition+Education+and+Behavior&rft.issn=14994046&rft_id=info:doi/10.1016%2Fj.jneb.2005.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 34 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Data processing; Typing; Drug resistance; Reviews; Disease control; Antibiotics; Infection; Pneumonia; Mycoplasma pneumoniae DO - http://dx.doi.org/10.1128/JCM.02597-14 ER - TY - JOUR T1 - Harmonization of Bordetella pertussis Real-Time PCR Diagnostics in the United States in 2012 AN - 1660385584; 21328465 AB - Real-time PCR (rt-PCR) is an important diagnostic tool for the identification of Bordetella pertussis, Bordetella holmesii, and Bordetella parapertussis. Most U.S. public health laboratories (USPHLs) target IS481, present in 218 to 238 copies in the B. pertussis genome and 32 to 65 copies in B. holmesii. The CDC developed a multitarget PCR assay to differentiate B. pertussis, B. holmesii, and B. parapertussis and provided protocols and training to 19 USPHLs. The 2012 performance exercise (PE) assessed the capability of USPHLs to detect these three Bordetella species in clinical samples. Laboratories were recruited by the Wisconsin State Proficiency Testing program through the Association of Public Health Laboratories, in partnership with the CDC. Spring and fall PE panels contained 12 samples each of viable Bordetella and non-Bordetella species in saline. Fifty and 53 USPHLs participated in the spring and fall PEs, respectively, using a variety of nucleic acid extraction methods, PCR platforms, and assays. Ninety-six percent and 94% of laboratories targeted IS481 in spring and fall, respectively, in either singleplex or multiplex assays. In spring and fall, respectively, 72% and 79% of USPHLs differentiated B. pertussis and B. holmesii and 68% and 72% identified B. parapertussis. IS481 cycle threshold (CT) values for B. pertussis samples had coefficients of variation (CV) ranging from 10% to 28%. Of the USPHLs that differentiated B. pertussis and B. holmesii, sensitivity was 96% and specificity was 95% for the combined panels. The 2012 PE demonstrated increased harmonization of rt-PCR Bordetella diagnostic protocols in USPHLs compared to that of the previous survey. JF - Journal of Clinical Microbiology AU - Williams, Margaret M AU - Taylor, Thomas H, Jr AU - Warshauer, David M AU - Martin, Monte D AU - Valley, Ann M AU - Tondella, M Lucia AD - Centers for Disease Control and Prevention, Atlanta, Georgia, USA, mwilliams7@cdc.gov. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 118 EP - 123 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 1 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Pertussis KW - Bordetella pertussis KW - nucleic acids KW - Bordetella KW - Bordetella holmesii KW - Bordetella parapertussis KW - Polymerase chain reaction KW - Public health KW - Physical training KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660385584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Harmonization+of+Bordetella+pertussis+Real-Time+PCR+Diagnostics+in+the+United+States+in+2012&rft.au=Williams%2C+Margaret+M%3BTaylor%2C+Thomas+H%2C+Jr%3BWarshauer%2C+David+M%3BMartin%2C+Monte+D%3BValley%2C+Ann+M%3BTondella%2C+M+Lucia&rft.aulast=Williams&rft.aufirst=Margaret&rft.date=2015-01-01&rft.volume=53&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02368-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 15 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Genomes; Pertussis; nucleic acids; Polymerase chain reaction; Physical training; Public health; Bordetella pertussis; Bordetella; Bordetella holmesii; Bordetella parapertussis DO - http://dx.doi.org/10.1128/JCM.02368-14 ER - TY - JOUR T1 - Annual risk of tuberculous infection measured using serial skin testing, Orel Oblast, Russia, 1991-2005 AN - 1655746503; PQ0001064051 AB - OBJECTIVE: To compare trends in direct annual risk of tuberculous infection (ARTI) during 1991-2005 in relation to tuberculosis (TB) incidence and to indirect estimates of ARTI derived from the prevalence of tuberculin skin test (TST) positivity in schoolchildren in Orel Oblast, Russia. DESIGN: In 2005, we abstracted annual TST results and vaccination histories from a representative sample of schoolchildren in Orel Oblast, Russia, where bacille Calmette-Guerin (BCG) vaccination and annual TST of children are nearly universal. We calculated direct ARTI based on the percentage of children tested with TST conversions each year, excluding conversions following BCG vaccination. RESULTS: We analysed records from 13 206 children, with a median of 10 recorded TST results per child. The ARTI increased from 0.2% in 1991 to 1.6% in 2000, paralleling trends in TB incidence. Similar results were observed when the ARTI was estimated based on prevalence of infection among children aged 3-5 years using a 12 mm cut-off to define TST positivity. Results differed substantially when 10 or 15 mm cut-offs were used or when prevalence was determined among children aged 6-8 years. CONCLUSION: ARTI measured through TST conversion increased as TB incidence increased in Orel Oblast. ARTI measured through serial TSTs can thus provide an indicator of changing trends in TB incidence. JF - International Journal of Tuberculosis and Lung Disease AU - Yuen, C M AU - Krapivina, T M AU - Kazennyy, B Y AU - Kiryanova, E V AU - Aksenova, V A AU - Gordina, A AU - Finlay, A M AU - Cegielski, J P AD - Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, pcegielski@cdc.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 39 EP - 43 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 1 SN - 1027-3719, 1027-3719 KW - Health & Safety Science Abstracts; Risk Abstracts KW - tuberculous infection KW - tuberculin test KW - Russia KW - Health risks KW - Historical account KW - INW, Russia KW - Mycobacterium KW - Lung KW - Tuberculosis KW - Vaccines KW - Children KW - Infection KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1655746503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Annual+risk+of+tuberculous+infection+measured+using+serial+skin+testing%2C+Orel+Oblast%2C+Russia%2C+1991-2005&rft.au=Yuen%2C+C+M%3BKrapivina%2C+T+M%3BKazennyy%2C+B+Y%3BKiryanova%2C+E+V%3BAksenova%2C+V+A%3BGordina%2C+A%3BFinlay%2C+A+M%3BCegielski%2C+J+P&rft.aulast=Yuen&rft.aufirst=C&rft.date=2015-01-01&rft.volume=19&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0445 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Historical account; Health risks; Lung; Tuberculosis; Vaccines; Infection; Children; Mycobacterium; INW, Russia; Russia DO - http://dx.doi.org/10.5588/ijtld.14.0445 ER - TY - JOUR T1 - Disparities in Capreomycin Resistance Levels Associated with the rrs A1401G Mutation in Clinical Isolates of Mycobacterium tuberculosis AN - 1654696836; 21328212 AB - As the prevalence of multidrug-resistant and extensively drug-resistant tuberculosis strains continues to rise, so does the need to develop accurate and rapid molecular tests to complement time-consuming growth-based drug susceptibility testing. Performance of molecular methods relies on the association of specific mutations with phenotypic drug resistance and while considerable progress has been made for resistance detection of first-line antituberculosis drugs, rapid detection of resistance for second-line drugs lags behind. The rrs A1401G allele is considered a strong predictor of cross-resistance between the three second-line injectable drugs, capreomycin (CAP), kanamycin, and amikacin. However, discordance is often observed between the rrs A1401G mutation and CAP resistance, with up to 40% of rrs A1401G mutants being classified as CAP susceptible. We measured the MICs to CAP in 53 clinical isolates harboring the rrs A1401G mutation and found that the CAP MICs ranged from 8 mu g/ml to 40 mu g/ml. These results were drastically different from engineered A1401G mutants generated in isogenic Mycobacterium tuberculosis, which exclusively exhibited high-level CAP MICs of 40 mu g/ml. These data support the results of prior studies, which suggest that the critical concentration of CAP (10 mu g/ml) used to determine resistance by indirect agar proportion may be too high to detect all CAP-resistant strains and suggest that a larger percentage of resistant isolates could be identified by lowering the critical concentration. These data also suggest that differences in resistance levels among clinical isolates are possibly due to second site or compensatory mutations located elsewhere in the genome. JF - Antimicrobial Agents & Chemotherapy AU - Reeves, Analise Z AU - Campbell, Patricia J AU - Willby, Melisa J AU - Posey, James E AD - Division of TB Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, jposey@cdc.gov. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 444 EP - 449 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Clinical isolates KW - Agar KW - Data processing KW - Amikacin KW - Drug resistance KW - Kanamycin KW - Minimum inhibitory concentration KW - Capreomycin KW - Discordance KW - Tuberculosis KW - Cross-resistance KW - Mutation KW - Mycobacterium tuberculosis KW - A 01350:Microbial Resistance KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654696836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Disparities+in+Capreomycin+Resistance+Levels+Associated+with+the+rrs+A1401G+Mutation+in+Clinical+Isolates+of+Mycobacterium+tuberculosis&rft.au=Reeves%2C+Analise+Z%3BCampbell%2C+Patricia+J%3BWillby%2C+Melisa+J%3BPosey%2C+James+E&rft.aulast=Reeves&rft.aufirst=Analise&rft.date=2015-01-01&rft.volume=59&rft.issue=1&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04438-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 31 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Genomes; Agar; Data processing; Amikacin; Drug resistance; Kanamycin; Minimum inhibitory concentration; Capreomycin; Discordance; Tuberculosis; Mutation; Cross-resistance; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/AAC.04438-14 ER - TY - JOUR T1 - Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses AN - 1654668676; 21169919 AB - Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with case fatality rates in the range 25-90%. The diagnosis of filovirus using formalin-fixed tissues from fatal cases poses a significant challenge. The most characteristic histopathological findings are seen in the liver; however, the findings overlap with many other viral and non-viral haemorrhagic diseases. The need to distinguish filovirus infections from other haemorrhagic fevers, particularly in areas with multiple endemic viral haemorrhagic agents, is of paramount importance. In this review we discuss the current state of knowledge of filovirus infections and their pathogenesis, including histopathological findings, epidemiology, modes of transmission and filovirus entry and spread within host organisms. The pathogenesis of filovirus infections is complex and involves activation of the mononuclear phagocytic system, with release of pro-inflammatory cytokines, chemokines and growth factors, endothelial dysfunction, alterations of the innate and adaptive immune systems, direct organ and endothelial damage from unrestricted viral replication late in infection, and coagulopathy. Although our understanding of the pathogenesis of filovirus infections has rapidly increased in the past few years, many questions remain unanswered. Copyright copyright 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. JF - Journal of Pathology AU - Martines, Roosecelis Brasil AU - Ng, Dianna L AU - Greer, Patricia W AU - Rollin, Pierre E AU - Zaki, Sherif R AD - Infectious Diseases Pathology Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA, USA. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 153 EP - 174 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 235 IS - 2 SN - 0022-3417, 0022-3417 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Tissues KW - Marburg virus KW - Chemokines KW - Pathology KW - Immune system KW - Viruses KW - Histopathology KW - Ebola virus KW - Infection KW - Phagocytes KW - Filovirus KW - Cytokines KW - Growth factors KW - Mortality KW - Replication KW - ANE, Eire KW - Tropism KW - Pathogens KW - Organs KW - Inflammation KW - Epidemiology KW - Reviews KW - Liver KW - Hemorrhagic fever KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654668676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pathology&rft.atitle=Tissue+and+cellular+tropism%2C+pathology+and+pathogenesis+of+Ebola+and+Marburg+viruses&rft.au=Martines%2C+Roosecelis+Brasil%3BNg%2C+Dianna+L%3BGreer%2C+Patricia+W%3BRollin%2C+Pierre+E%3BZaki%2C+Sherif+R&rft.aulast=Martines&rft.aufirst=Roosecelis&rft.date=2015-01-01&rft.volume=235&rft.issue=2&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pathology&rft.issn=00223417&rft_id=info:doi/10.1002%2Fpath.4456 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Chemokines; Replication; Immune system; Tropism; Pathogens; Infection; Inflammation; Epidemiology; Phagocytes; Liver; Hemorrhagic fever; Cytokines; Growth factors; Mortality; Tissues; Pathology; Reviews; Viruses; Histopathology; Organs; Marburg virus; Filovirus; Ebola virus; ANE, Eire DO - http://dx.doi.org/10.1002/path.4456 ER - TY - JOUR T1 - Outcomes of pediatric severe traumatic brain injury patients treated in adult trauma centers with and without added qualifications in pediatrics - United States, 2009 AN - 1855073181; PQ0001930683 AB - Background: Pediatric traumatic brain injury (TBI) is an important public health problem and little is known about site of care and outcomes of children with severe TBI. Across the country, most injured children are treated in adult trauma centers (ATCs). Recent literature suggests that ATCs with added qualifications in pediatrics (ATC-AQs) can have improved outcomes for pediatric trauma patients overall. This study characterizes the population of pediatric severe TBI patients treated at ATCs and investigates the effect of treatment at ATC-AQs versus ATCs on mortality. Methods: Using the 2009 National Trauma Data Bank, pediatric (age 0-17 years old) severe TBI (head Abbreviated Injury Scale score greater than or equal to 3) patient visits at level I and II ATCs and ATC-AQs were analyzed for patient and hospital characteristics. The primary outcome was in-patient mortality. Multivariate analysis was performed on propensity score weighted populations to investigate effect of treatment at ATC-AQs versus ATCs on survival. Results: A total of 7,057 pediatric severe TBI patient visits in 398 level I and II trauma centers were observed, with 3,496 (49.5%) at ATC-AQs and 3,561 (50.5%) at ATCs. The mortality rate was 8.6% at ATC-AQs versus 10.3% at ATCs (p =0.0144). After adjusting for differences in case mix, patient, and hospital characteristics, mortality was not significantly different for patients treated in ATC-AQs versus ATCs (aOR=0.896, 95% CI=0.629-1.277). Mortality was significantly associated with age, length of hospital stay, firearm injury, GCS score, and head AIS (p <0.0001). Higher mortality odds were also associated with being uninsured (aOR=2.102, 95% CI=1.159-3.813), and the presence of additional non-TBI severe injuries (aOR=1.936 95% CI=1.175-3.188). Conclusions: After defining comparable populations, this study demonstrated no significant difference in mortality for pediatric severe TBI patients treated at ATC-AQs versus ATCs. Being younger, uninsured, and having severe injuries was associated with increased mortality. This study is limited by the exclusion of transferred patients and potentially underestimates differences in outcomes. Further research is needed to clarify the role of ATC additional pediatric qualifications in the treatment of severe TBI. JF - Injury Epidemiology AU - Ovalle, Fernando AU - Xu, Likang AU - Pearson, William S AU - Spelke, Bridget AU - Sugerman, David E AD - Division of Injury Response, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4470 Buford Highway NE, MS-F62, Atlanta, GA, 30341, USA, ggi4@cdc.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1 EP - 10 PB - Springer Science & Business Media, Cham VL - 1 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Mortality KW - Age KW - Injuries KW - Head KW - Pediatrics KW - Survival KW - Population studies KW - Children KW - Public health KW - Data banks KW - Multivariate analysis KW - Geriatrics KW - Traumatic brain injury KW - Hospitals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855073181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Epidemiology&rft.atitle=Outcomes+of+pediatric+severe+traumatic+brain+injury+patients+treated+in+adult+trauma+centers+with+and+without+added+qualifications+in+pediatrics+-+United+States%2C+2009&rft.au=Ovalle%2C+Fernando%3BXu%2C+Likang%3BPearson%2C+William+S%3BSpelke%2C+Bridget%3BSugerman%2C+David+E&rft.aulast=Ovalle&rft.aufirst=Fernando&rft.date=2014-12-01&rft.volume=1&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Injury+Epidemiology&rft.issn=2197-1714&rft_id=info:doi/10.1186%2F2197-1714-1-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 39 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Head; Injuries; Pediatrics; Population studies; Survival; Children; Public health; Data banks; Multivariate analysis; Geriatrics; Traumatic brain injury; Hospitals DO - http://dx.doi.org/10.1186/2197-1714-1-15 ER - TY - JOUR T1 - Co-Infection of Rickettsia rickettsii and Streptococcus pyogenes: Is Fatal Rocky Mountain Spotted Fever Underdiagnosed? AN - 1727697583; PQ0002140042 AB - Rocky Mountain spotted fever, a tick-borne disease caused by Rickettsia rickettsii, is challenging to diagnose and rapidly fatal if not treated. We describe a decedent who was co-infected with group A [beta]-hemolytic streptococcus and R. rickettsii. Fatal cases of Rocky Mountain spotted fever may be underreported because they present as difficult to diagnose co-infections. JF - American Journal of Tropical Medicine and Hygiene AU - Raczniak, Gregory A AU - Kato, Cecilia AU - Chung, Ida H AU - Austin, Amy AU - McQuiston, Jennifer H AU - Weis, Erica AU - Levy, Craig AU - Carvalho, Maria da Gloria S AU - Mitchell, Audrey AU - Bjork, Adam AU - Regan, Joanna J AD - Epidemic Intelligence Service, Center for Surveillance, Epidemiology and Laboratory Services, Rickettsial Zoonoses Branch, National Center for Emerging and Zoonotic Infectious Diseases, Streptococcus Laboratory, National Center for Immunization and Respiratory Diseases, HIV Prevention Branch, Division of Global HIV/AIDS, Center for Global Health, Border Health Services Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, vih5@cdc.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1154 EP - 1155 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 6 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - North America, Rocky Mts. KW - Rocky Mountain spotted fever KW - tick-borne diseases KW - Rickettsia rickettsii KW - Hygiene KW - Streptococcus pyogenes KW - K 03490:Miscellaneous KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727697583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Co-Infection+of+Rickettsia+rickettsii+and+Streptococcus+pyogenes%3A+Is+Fatal+Rocky+Mountain+Spotted+Fever+Underdiagnosed%3F&rft.au=Raczniak%2C+Gregory+A%3BKato%2C+Cecilia%3BChung%2C+Ida+H%3BAustin%2C+Amy%3BMcQuiston%2C+Jennifer+H%3BWeis%2C+Erica%3BLevy%2C+Craig%3BCarvalho%2C+Maria+da+Gloria+S%3BMitchell%2C+Audrey%3BBjork%2C+Adam%3BRegan%2C+Joanna+J&rft.aulast=Raczniak&rft.aufirst=Gregory&rft.date=2014-12-01&rft.volume=91&rft.issue=6&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Hygiene; Rocky Mountain spotted fever; tick-borne diseases; Rickettsia rickettsii; Streptococcus pyogenes; North America, Rocky Mts. DO - http://dx.doi.org/10.4269/ajtmh.14-0437 ER - TY - JOUR T1 - Integrating active tuberculosis case finding in antenatal services in Zambia AN - 1654680496; 21194774 AB - SETTING: Three out-patient antenatal care (ANC) clinics in Lusaka, Zambia. OBJECTIVE: To estimate tuberculosis (TB) prevalence in human immunodeficiency virus (HIV) infected and symptomatic, non-HIV-infected pregnant women and explore the feasibility of routine TB screening in ANC settings. DESIGN: Peer educators administered TB symptom questionnaires to pregnant women attending their first ANC clinic visit. Presumptive TB patients were defined as all HTV-infected women and symptomatic non-HIV-infected women. Sputum samples were tested using smear microscopy and culture to estimate TB prevalence. RESULTS: All 5033 (100%) women invited to participate in the study agreed, and 17% reported one or more TB symptoms. Among 1152 presumed TB patients, 17 (1.5%) had previously undiagnosed culture-confirmed TB; 2 (12%) were smear-positive. Stratified by HIV status, TB prevalence was 10/664 (1.5%, 95%CI 0.7-2.8) among HIV-infected women and 7/488 (1.4%, 95%CI 0.6-2.9) among symptomatic non-HIV-infected women. In HIV-infected women, the only symptom significantly associated with TB was productive cough; symptom screening was only 50% sensitive. CONCLUSION: There is a sizable burden of TB in pregnant women in Zambia, which may lead to adverse maternal and infant outcomes. TB screening in ANC settings in Zambia is acceptable and feasible. More sensitive diagnostics are needed. JF - International Journal of Tuberculosis and Lung Disease AU - Kancheya, N AU - Luhanga, D AU - Harris, J B AU - Morse, J AU - Kapata, N AU - Bweupe, M AU - Henostroza, G AU - Reid, S E AD - Centre for Infectious Disease Research in Zambia, Lusaka, Zambia; Centers for Disease Control and Prevention (CDC), 351 Independence Avenue, US Embassy/CDC, PO Box 31617, Lusaka, Zambia, yde3@cdc.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1466 EP - 1472 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 18 IS - 12 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - pregnancy KW - tuberculosis screening KW - ante-natal clinics KW - Zambia KW - Inventories KW - Human immunodeficiency virus KW - Mycobacterium KW - Microscopy KW - Lung diseases KW - Cough KW - Tuberculosis KW - Sputum KW - Pregnancy KW - Infants KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654680496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Integrating+active+tuberculosis+case+finding+in+antenatal+services+in+Zambia&rft.au=Kancheya%2C+N%3BLuhanga%2C+D%3BHarris%2C+J+B%3BMorse%2C+J%3BKapata%2C+N%3BBweupe%2C+M%3BHenostroza%2C+G%3BReid%2C+S+E&rft.aulast=Kancheya&rft.aufirst=N&rft.date=2014-12-01&rft.volume=18&rft.issue=12&rft.spage=1466&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0920 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Inventories; Microscopy; Lung diseases; Cough; Tuberculosis; Sputum; Infants; Pregnancy; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.5588/ijtld.14.0920 ER - TY - JOUR T1 - Bedbug Complaints among Public Housing Residents-New York City, 2010-2011 AN - 1642626443; 21151059 AB - Few studies have evaluated population-level risk factors for having a bedbug infestation. We describe characteristics associated with bedbug complaints among New York City Housing Authority (NYCHA) residents. Unique households receiving bedbug extermination services in response to a complaint during January 1, 2010 to December 31, 2011 were identified from NYCHA's central facilities work order database. We examined associations between household characteristics and having a bedbug complaint using a generalized estimating equation Poisson regression model, accounting for clustering by housing development. Of the 176,327 NYCHA households, 11,660 (6.6 %) registered a bedbug complaint during 2010-2011. Bedbug complaints were independently associated with households having five or more children versus no children (prevalence ratio [PR]=2.0), five or more adults versus one adult (PR=1.6), a head of household (HOH) with impaired mobility (PR=1.3), a household member receiving public assistance (PR=1.2), a household income below poverty level (PR=1.1), and a female HOH (PR=1.1). Infestations were less likely to be reported by households with employed members (PR=0.9), and an HOH aged 30-44 years (PR=0.9) or 45-61 years (PR=0.9), compared with an HOH aged 18-29 years. These results indicate that bedbug control efforts in public housing should be targeted toward households with low income and high occupancy. JF - Journal of Urban Health AU - Gounder, Prabhu AU - Ralph, Nancy AU - Maroko, Andrew AU - Thorpe, Lorna AD - Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK, USA, iym4@cdc.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1076 EP - 1086 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 91 IS - 6 SN - 1099-3460, 1099-3460 KW - Risk Abstracts; Health & Safety Science Abstracts KW - USA, New York, New York City KW - Housing developments KW - Housing KW - Mobility KW - Households KW - Risk factors KW - Poverty KW - Children KW - Income KW - Urban areas KW - H 0500:General KW - R2 23070:Economics, organization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642626443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urban+Health&rft.atitle=Bedbug+Complaints+among+Public+Housing+Residents-New+York+City%2C+2010-2011&rft.au=Gounder%2C+Prabhu%3BRalph%2C+Nancy%3BMaroko%2C+Andrew%3BThorpe%2C+Lorna&rft.aulast=Gounder&rft.aufirst=Prabhu&rft.date=2014-12-01&rft.volume=91&rft.issue=6&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urban+Health&rft.issn=10993460&rft_id=info:doi/10.1007%2Fs11524-013-9859-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 28 N1 - Last updated - 2015-02-18 N1 - SubjectsTermNotLitGenreText - Housing developments; Mobility; Housing; Poverty; Risk factors; Households; Children; Urban areas; Income; USA, New York, New York City DO - http://dx.doi.org/10.1007/s11524-013-9859-y ER - TY - JOUR T1 - pncA and bptA Are Not Sufficient To Complement Ixodes scapularis Colonization and Persistence by Borrelia burgdorferi in a Linear Plasmid lp25-Deficient Background AN - 1642614142; 21154669 AB - The complex segmented genome of Borrelia burgdorferi is comprised of a linear chromosome along with numerous linear and circular plasmids essential for tick and/or mammalian infectivity. The pathogenic necessity for specific borrelial plasmids has been identified; most notably, infections of the tick vector and mammalian host both require linear plasmid 25 (lp25). Genes carried on lp25, specifically bptA and pncA, are postulated to play a role for B. burgdorferi to infect and persist in Ixodes ticks. In this study, we complemented an lp25-deficient borrelial strain with pncA alone or pncA accompanied by bptA to evaluate the ability of the complemented strains to restore larval colonization and persistence through transstadial transmission relative to that of wild-type B. burgdorferi. The acquisition of the complemented strains by tick larvae from infected mice and/or the survival of these strains was significantly decreased when assayed by cultivation and quantitative PCR (qPCR). Only 10% of the pncA-complemented strain organisms were found by culture to survive 17 days following larval feeding, while 45% of the pncA- and bptA-complemented strain organisms survived, with similar results by PCR. However, neither of the complemented B. burgdorferi strains was capable of persisting through the molt to the nymphal stage as analyzed by culture. qPCR analyses of unfed nymphs detected B. burgdorferi genomes in several nymphs at low copy numbers, likely indicating the presence of DNA from dead or dying cells. Overall, the data indicate that pncA and bptA cannot independently support infection, suggesting that lp25 carries additional gene(s) or regulatory elements critical for B. burgdorferi survival and pathogenesis in the Ixodes vector. JF - Infection and Immunity AU - Gilmore, Robert D AU - Brandt, Kevin S AU - Hyde, Jenny A AD - National Center for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA, jshyde@medicine.tamhsc.edu. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 5110 EP - 5116 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 12 SN - 0019-9567, 0019-9567 KW - Entomology Abstracts; Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Ixodes KW - Genomes KW - Feeding KW - Data processing KW - Borrelia burgdorferi KW - Ixodidae KW - Regulatory sequences KW - Larvae KW - Survival KW - Vectors KW - Cell culture KW - Ixodes scapularis KW - Molting KW - Infection KW - Plasmids KW - copy number KW - Disease transmission KW - Colonization KW - Chromosomes KW - Infectivity KW - Polymerase chain reaction KW - Z 05360:Genetics and Evolution KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642614142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=pncA+and+bptA+Are+Not+Sufficient+To+Complement+Ixodes+scapularis+Colonization+and+Persistence+by+Borrelia+burgdorferi+in+a+Linear+Plasmid+lp25-Deficient+Background&rft.au=Gilmore%2C+Robert+D%3BBrandt%2C+Kevin+S%3BHyde%2C+Jenny+A&rft.aulast=Gilmore&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=82&rft.issue=12&rft.spage=5110&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.02613-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 44 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Genomes; Feeding; Data processing; Regulatory sequences; Larvae; Vectors; Survival; Cell culture; Plasmids; Infection; Molting; Disease transmission; copy number; Colonization; Infectivity; Chromosomes; Polymerase chain reaction; Ixodes; Borrelia burgdorferi; Ixodidae; Ixodes scapularis DO - http://dx.doi.org/10.1128/IAI.02613-14 ER - TY - JOUR T1 - Complications of cesarean deliveries among HIV-infected women in the United States AN - 1765971965; PQ0002559503 AB - Objective: To compare rates of complications associated with cesarean delivery in HIV-infected and HIV-uninfected women in the United States and to investigate trends in such complications across four study cycles spanning the implementation of HAART in the United States (1995-1996, 2000-2001, 2005-2006, 2010-2011). Design: The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project is the largest all-payer hospital inpatient care database in the United States; when weighted to account for the complex sampling design, nationally representative estimates are derived. After restricting the study sample to women aged 15-49 years, our study sample consisted of approximately 1 090 000 cesarean delivery hospitalizations annually. Methods: Complications associated with cesarean deliveries were categorized as infection, hemorrhage, or surgical trauma, based on groups of specific International Classification of Diseases 9th revision codes. Length of hospitalization, hospital charges, and in-hospital deaths were also examined. Results: The rate of complications significantly decreased during the study periods for HIV-infected and HIV-uninfected women. However, rates of infectious complications and surgical trauma associated with cesarean deliveries remained higher among HIV-infected, compared with HIV-uninfected women in 2010-2011, as did prolonged hospital stay and in-hospital deaths. Length of hospitalization decreased over time for cesarean deliveries of HIV-infected women to a greater extent compared with HIV-uninfected women. Conclusion: In the United States, rates of cesarean delivery complications decreased from 1995 to 2011. However, rates of infection, surgical trauma, hospital deaths, and prolonged hospitalization are still higher among HIV-infected women. Clinicians should remain alert to this persistently increased risk of cesarean delivery complications among HIV-infected women. JF - AIDS AU - Kourtis, Athena P AU - Ellington, Sascha AU - Pazol, Karen AU - Flowers, Lisa AU - Haddad, Lisa AU - Jamieson, Denise J AD - Women's Health and Fertility Branch, Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, apk3@cdc.gov Y1 - 2014/11/13/ PY - 2014 DA - 2014 Nov 13 SP - 2609 EP - 2618 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 28 IS - 17 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - AIDS KW - cesarean section KW - HAART KW - HIV KW - obstetric labor complications KW - Mortality KW - Acquired immune deficiency syndrome KW - Complications KW - Infection KW - Hemorrhage KW - Trauma KW - Databases KW - USA KW - Health care KW - Classification KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - Surgery KW - Cesarean section KW - Females KW - Sampling KW - Hospitals KW - V 22360:AIDS and HIV KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765971965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Complications+of+cesarean+deliveries+among+HIV-infected+women+in+the+United+States&rft.au=Kourtis%2C+Athena+P%3BEllington%2C+Sascha%3BPazol%2C+Karen%3BFlowers%2C+Lisa%3BHaddad%2C+Lisa%3BJamieson%2C+Denise+J&rft.aulast=Kourtis&rft.aufirst=Athena&rft.date=2014-11-13&rft.volume=28&rft.issue=17&rft.spage=2609&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Databases; Classification; highly active antiretroviral therapy; Cesarean section; Sampling; Hemorrhage; Infection; Trauma; Hospitals; Mortality; Acquired immune deficiency syndrome; Health care; Complications; Surgery; Females; Human immunodeficiency virus; USA DO - http://dx.doi.org/10.1097/QAD.0000000000000474 ER - TY - JOUR T1 - Narcolepsy and influenza A(H1N1) pandemic 2009 vaccination in the United States AN - 1687672295; PQ0001546665 AB - Objective: To assess the occurrence of narcolepsy after influenza vaccines used in the United States that contained the influenza A(H1N1)pdm09 virus strain. Methods: A population-based cohort study in the Vaccine Safety Datalink with an annual population of more than 8.5 million people. All persons younger than 30 years who received a 2009 pandemic or a 2010-2011 seasonal influenza vaccine were identified. Their medical visit history was searched for a first-ever occurrence of an ICD-9 narcolepsy diagnosis code through the end of 2011. Chart review was done to confirm the diagnosis and determine the date of symptom onset. Cases were patients who met the International Classification of Sleep Disorders, 2nd edition, narcolepsy diagnostic criteria. We compared the observed number of cases after vaccination to the number expected to occur by chance alone. Results: The number vaccinated with 2009 pandemic vaccine was 650,995 and with 2010-2011 seasonal vaccine was 870,530. Among these patients, 70 had a first-ever narcolepsy diagnosis code after vaccination, of which 16 had a chart-confirmed incident diagnosis of narcolepsy. None had their symptom onset during the 180 days after receipt of a 2009 pandemic vaccine compared with 6.52 expected, and 2 had onset after a 2010-2011 seasonal vaccine compared with 8.83 expected. Conclusions: Influenza vaccines containing the A(H1N1)pdm09 virus strain used in the United States were not associated with an increased risk of narcolepsy. Vaccination with the influenza A(H1N1)pdm09 vaccine viral antigens does not appear to be sufficient by itself to increase the incidence of narcolepsy in a population. JF - Neurology AU - Duffy, Jonathan AU - Weintraub, Eric AU - Vellozzi, Claudia AU - DeStefano, Frank AD - Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, GA, jduffy@cdc.gov Y1 - 2014/11/11/ PY - 2014 DA - 2014 Nov 11 SP - 1823 EP - 1830 PB - Lippincott Williams & Wilkins, 16522 Hunters Green Parkway Hagerstown MD 21740-2116 United States VL - 83 IS - 20 SN - 0028-3878, 0028-3878 KW - Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - Historical account KW - Sleep disorders KW - Safety KW - Influenza KW - USA KW - pandemics KW - Sulfur dioxide KW - Classification KW - Narcolepsy KW - Reviews KW - Vaccines KW - Seasonal variations KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687672295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Narcolepsy+and+influenza+A%28H1N1%29+pandemic+2009+vaccination+in+the+United+States&rft.au=Duffy%2C+Jonathan%3BWeintraub%2C+Eric%3BVellozzi%2C+Claudia%3BDeStefano%2C+Frank&rft.aulast=Duffy&rft.aufirst=Jonathan&rft.date=2014-11-11&rft.volume=83&rft.issue=20&rft.spage=1823&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/10.1212%2FWNL.0000000000000987 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-08-19 N1 - SubjectsTermNotLitGenreText - Influenza; pandemics; Classification; Sleep disorders; Narcolepsy; Vaccines; Risk assessment; Historical account; Sulfur dioxide; Reviews; Safety; Seasonal variations; USA DO - http://dx.doi.org/10.1212/WNL.0000000000000987 ER - TY - JOUR T1 - Primary prevention of lead poisoning in children: a cross-sectional study to evaluate state specific lead-based paint risk reduction laws in preventing lead poisoning in children. AN - 1627071895; 25380793 AB - Children younger than 72 months are most at risk of environmental exposure to lead from ingestion through normal mouthing behavior. Young children are more vulnerable to lead poisoning than adults because lead is absorbed more readily in a child's gastrointestinal tract. Our focus in this study was to determine the extent to which state mandated lead laws have helped decrease the number of new cases of elevated blood-lead levels (EBLL) in homes where an index case had been identified. A cross-sectional study was conducted to compare 682 residential addresses, identified between 2000 and 2009, in two states with and one state without laws to prevent childhood lead poisoning among children younger than 72 months, to determine whether the laws were effective in preventing subsequent cases of lead poisoning detected in residential addresses after the identification of an index case. In this study, childhood lead poisoning was defined as the blood lead level (BLL) that would have triggered an environmental investigation in the residence. The two states with lead laws, Massachusetts (MA) and Ohio (OH), had trigger levels of ≥25 μg/dL and ≥15 μg/dL respectively. In Mississippi (MS), the state without legislation, the trigger level was ≥15 μg/dL. The two states with lead laws, MA and OH, were 79% less likely than the one without legislation, MS, to have residential addresses with subsequent lead poisoning cases among children younger than 72 months, adjusted OR = 0.21, 95% CI (0.08-0.54). For the three states studied, the evidence suggests that lead laws such as those studied herein effectively reduced primary exposure to lead among young children living in residential addresses that may have had lead contaminants. JF - Environmental health : a global access science source AU - Kennedy, Chinaro AU - Lordo, Robert AU - Sucosky, Marissa Scalia AU - Boehm, Rona AU - Brown, Mary Jean AD - Centers for Disease Control and Prevention, National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, 4770 Buford Highway, Atlanta, GA 30341, USA. gjn5@cdc.gov. Y1 - 2014/11/07/ PY - 2014 DA - 2014 Nov 07 SP - 93 VL - 13 KW - Index Medicus KW - Infant KW - Cross-Sectional Studies KW - Housing KW - Massachusetts KW - Humans KW - Mississippi KW - Infant, Newborn KW - Male KW - Female KW - Ohio KW - Child, Preschool KW - Lead Poisoning -- prevention & control KW - Primary Prevention -- legislation & jurisprudence KW - Environmental Exposure -- legislation & jurisprudence KW - Paint -- poisoning KW - Environmental Exposure -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627071895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+%3A+a+global+access+science+source&rft.atitle=Primary+prevention+of+lead+poisoning+in+children%3A+a+cross-sectional+study+to+evaluate+state+specific+lead-based+paint+risk+reduction+laws+in+preventing+lead+poisoning+in+children.&rft.au=Kennedy%2C+Chinaro%3BLordo%2C+Robert%3BSucosky%2C+Marissa+Scalia%3BBoehm%2C+Rona%3BBrown%2C+Mary+Jean&rft.aulast=Kennedy&rft.aufirst=Chinaro&rft.date=2014-11-07&rft.volume=13&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Environmental+health+%3A+a+global+access+science+source&rft.issn=1476-069X&rft_id=info:doi/10.1186%2F1476-069X-13-93 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-04 N1 - Date created - 2014-11-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Public Health. 2001 Apr;91(4):621-4 [11291376] Public Health Rep. 2000 Nov-Dec;115(6):521-9 [11354334] WMJ. 2001;100(8):48-54 [12685297] N Engl J Med. 2003 Apr 17;348(16):1517-26 [12700371] Arch Environ Health. 1980 Jan-Feb;35(1):53-8 [7362271] MMWR Morb Mortal Wkly Rep. 1985 Feb 8;34(5):66-8, 73 [2982087] J Health Polit Policy Law. 2013 Aug;38(4):757-813 [23645870] Pediatrics. 1996 Jul;98(1):35-40 [8668409] Environ Health Perspect. 2005 Jul;113(7):894-9 [16002379] Pediatrics. 2006 Jan;117(1):147-53 [16396872] Environ Health Perspect. 2008 Feb;116(2):243-8 [18288325] MMWR Morb Mortal Wkly Rep. 2009 Jan 30;58(3):55-8 [19177040] Public Health Rep. 2011 May-Jun;126 Suppl 1:76-88 [21563715] N Engl J Med. 1990 Jan 11;322(2):83-8 [2294437] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/1476-069X-13-93 ER - TY - JOUR T1 - Prevalence of Strongyloides stercoralis Antibodies among a Rural Appalachian Population-Kentucky, 2013 AN - 1722180406; PQ0002099262 AB - We investigated whether Strongyloides infection remains endemic in rural Kentucky's Appalachian regions; 7 of 378 (1.9%) participants tested positive for Strongyloides antibodies. We identified no statistically significant association between a positive test and travel to a known endemic country (P = 0.58), indicating that transmission in rural Kentucky might be ongoing. Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. JF - American Journal of Tropical Medicine and Hygiene AU - Russell, Elizabeth S AU - Gray, Elizabeth B AU - Marshall, Rebekah E AU - Davis, Stephanie AU - Beaudoin, Amanda AU - Handali, Sukwan AU - McAuliffe, Isabel AU - Davis, Cheryl AU - Woodhall, Dana AD - Kentucky Department for Public Health, Frankfort, Kentucky, EBGray@cdc.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1000 EP - 1001 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Travel KW - Statistical analysis KW - Disease control KW - Infection KW - Strongyloides KW - Antibodies KW - Endemic species KW - USA, Kentucky KW - Strongyloides stercoralis KW - Hygiene KW - K 03300:Methods KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722180406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Prevalence+of+Strongyloides+stercoralis+Antibodies+among+a+Rural+Appalachian+Population-Kentucky%2C+2013&rft.au=Russell%2C+Elizabeth+S%3BGray%2C+Elizabeth+B%3BMarshall%2C+Rebekah+E%3BDavis%2C+Stephanie%3BBeaudoin%2C+Amanda%3BHandali%2C+Sukwan%3BMcAuliffe%2C+Isabel%3BDavis%2C+Cheryl%3BWoodhall%2C+Dana&rft.aulast=Russell&rft.aufirst=Elizabeth&rft.date=2014-11-01&rft.volume=91&rft.issue=5&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0310 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Endemic species; Antibodies; Disease control; Hygiene; Travel; Statistical analysis; Infection; Strongyloides; Strongyloides stercoralis; USA, Kentucky DO - http://dx.doi.org/10.4269/ajtmh.14-0310 ER - TY - JOUR T1 - Soil-Transmitted Helminths in Pre-School-Aged and School-Aged Children in an Urban Slum: A Cross-Sectional Study of Prevalence, Distribution, and Associated Exposures AN - 1722172947; PQ0002099263 AB - Soil-transmitted helminths (STHs) are controlled by regular mass drug administration. Current practice targets school-age children (SAC) preferentially over pre-school age children (PSAC) and treats large areas as having uniform prevalence. We assessed infection prevalence in SAC and PSAC and spatial infection heterogeneity, using a cross-sectional study in two slum villages in Kibera, Nairobi. Nairobi has low reported STH prevalence. The SAC and PSAC were randomly selected from the International Emerging Infections Program's surveillance platform. Data included residence location and three stools tested by Kato-Katz for STHs. Prevalences among 692 analyzable children were any STH: PSAC 40.5%, SAC 40.7%; Ascaris: PSAC 24.1%, SAC 22.7%; Trichuris: PSAC 24.0%, SAC 28.8%; hookworm < 0.1%. The STH infection prevalence ranged from 22% to 71% between sub-village sectors. The PSAC have similar STH prevalences to SAC and should receive deworming. Small areas can contain heterogeneous prevalences; determinants of STH infection should be characterized and slums should be assessed separately in STH mapping. JF - American Journal of Tropical Medicine and Hygiene AU - Davis, Stephanie M AU - Worrell, Caitlin M AU - Wiegand, Ryan E AU - Odero, Kennedy O AU - Suchdev, Parminder S AU - Ruth, Laird J AU - Lopez, Gerard AU - Cosmas, Leonard AU - Neatherlin, John AU - Njenga, Sammy M AU - Montgomery, Joel M AU - Fox, LeAnne M AD - Parasitic Diseases Branch, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, Vic6@cdc.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1002 EP - 1010 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Age KW - Data processing KW - Surveillance and enforcement KW - Kenya, Nairobi KW - Infection KW - Children KW - Ascaris KW - Mapping KW - Feces KW - Hygiene KW - Drugs KW - K 03400:Human Diseases KW - J 02400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722172947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Soil-Transmitted+Helminths+in+Pre-School-Aged+and+School-Aged+Children+in+an+Urban+Slum%3A+A+Cross-Sectional+Study+of+Prevalence%2C+Distribution%2C+and+Associated+Exposures&rft.au=Davis%2C+Stephanie+M%3BWorrell%2C+Caitlin+M%3BWiegand%2C+Ryan+E%3BOdero%2C+Kennedy+O%3BSuchdev%2C+Parminder+S%3BRuth%2C+Laird+J%3BLopez%2C+Gerard%3BCosmas%2C+Leonard%3BNeatherlin%2C+John%3BNjenga%2C+Sammy+M%3BMontgomery%2C+Joel+M%3BFox%2C+LeAnne+M&rft.aulast=Davis&rft.aufirst=Stephanie&rft.date=2014-11-01&rft.volume=91&rft.issue=5&rft.spage=1002&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Surveillance and enforcement; Hygiene; Drugs; Age; Data processing; Mapping; Feces; Children; Infection; Ascaris; Kenya, Nairobi DO - http://dx.doi.org/10.4269/ajtmh.14-0060 ER - TY - JOUR T1 - Viability of Leptospira Isolates from a Human Outbreak in Thailand in Various Water Types, pH, and Temperature Conditions AN - 1722169725; PQ0002099266 AB - Leptospira spp. isolated from patients during a multiyear outbreak in Thailand were genotyped using multilocus sequence typing and a majority were identified as ST34, especially in earlier years. We tested whether ST34 isolates were better adapted to survive in various pH levels, temperatures, and water sources. Motility and growth were monitored over a 1 2-week period. Early year ST34 isolates did not appear to have a significant fitness advantage over non-ST34, however, this may have been because a majority of the isolates survived to the termination of the study, with the exception being at high temperature (37[degrees]C) and/or basic pH (8.65). Failure to detect a significant fitness advantage of ST34 may be a result of the length of the study or the small sample size. Lengthening the study and looking at virulence and maintenance in the host could yield additional information about this outbreak. JF - American Journal of Tropical Medicine and Hygiene AU - Stoddard, Robyn A AU - Bui, Duy AU - Haberling, Dana L AU - Wuthiekanun, Vanaporn AU - Thaipadungpanit, Janjira AU - Hoffmaster, Alex R AD - Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, RAStoddard@cdc.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1020 EP - 1022 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Fitness KW - Temperature effects KW - Leptospira KW - Water temperature KW - multilocus sequence typing KW - Virulence KW - Motility KW - Growth KW - ISEW, Thailand KW - Hygiene KW - pH effects KW - pH KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722169725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Viability+of+Leptospira+Isolates+from+a+Human+Outbreak+in+Thailand+in+Various+Water+Types%2C+pH%2C+and+Temperature+Conditions&rft.au=Stoddard%2C+Robyn+A%3BBui%2C+Duy%3BHaberling%2C+Dana+L%3BWuthiekanun%2C+Vanaporn%3BThaipadungpanit%2C+Janjira%3BHoffmaster%2C+Alex+R&rft.aulast=Stoddard&rft.aufirst=Robyn&rft.date=2014-11-01&rft.volume=91&rft.issue=5&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Temperature effects; Virulence; Growth; Hygiene; pH; Fitness; Motility; Water temperature; pH effects; multilocus sequence typing; Leptospira; ISEW, Thailand DO - http://dx.doi.org/10.4269/ajtmh.13-0748 ER - TY - JOUR T1 - Vaccine-Derived Polioviruses AN - 1687678188; PQ0001574039 AB - The attenuated oral poliovirus vaccine (OPV) has many properties favoring its use in polio eradication: ease of administration, efficient induction of intestinal immunity, induction of durable humoral immunity, and low cost. Despite these advantages, OPV has the disadvantage of genetic instability, resulting in rare and sporadic cases of vaccine-associated paralytic poliomyelitis (VAPP) and the emergence of genetically divergent vaccine-derived polioviruses (VDPVs). Whereas VAPP is an adverse event following exposure to OPV, VDPVs are polioviruses whose genetic properties indicate prolonged replication or transmission. Three categories of VDPVs are recognized: (1) circulating VDPVs (cVDPVs) from outbreaks in settings of low OPV coverage, (2) immunodeficiency-associated VDPVs (iVDPVs) from individuals with primary immunodeficiencies, and (3) ambiguous VDPVs (aVDPVs), which cannot be definitively assigned to either of the first 2 categories. Because most VDPVs are type 2, the World Health Organization's plans call for coordinated worldwide replacement of trivalent OPV with bivalent OPV containing poliovirus types 1 and 3. JF - Journal of Infectious Diseases AU - Burns, Cara C AU - Diop, Ousmane M AU - Sutter, Roland W AU - Kew, Olen M AD - Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, cburns@cdc.gov Y1 - 2014/11/01/ PY - 2014 DA - 2014 Nov 01 SP - S283 EP - S293 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 210 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - poliovirus KW - vaccine-derived poliovirus KW - VDPV KW - oral poliovirus vaccine KW - OPV KW - poliomyelitis KW - Poliovirus KW - Replication KW - Immunodeficiency KW - vaccine-associated paralytic poliomyelitis KW - Disease transmission KW - Immunity (humoral) KW - Infectious diseases KW - Intestine KW - Outbreaks KW - Vaccines KW - Side effects KW - V 22320:Replication KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687678188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Vaccine-Derived+Polioviruses&rft.au=Burns%2C+Cara+C%3BDiop%2C+Ousmane+M%3BSutter%2C+Roland+W%3BKew%2C+Olen+M&rft.aulast=Burns&rft.aufirst=Cara&rft.date=2014-11-01&rft.volume=210&rft.issue=&rft.spage=S283&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu295 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Immunity (humoral); Replication; Immunodeficiency; Intestine; Vaccines; vaccine-associated paralytic poliomyelitis; Disease transmission; Poliovirus; Infectious diseases; Outbreaks; Side effects DO - http://dx.doi.org/10.1093/infdis/jiu295 ER - TY - JOUR T1 - Post-licensure surveillance of trivalent live attenuated influenza vaccine in adults, United States, Vaccine Adverse Event Reporting System (VAERS), July 2005-June 2013 AN - 1664206158; PQ0001196985 AB - Background Trivalent live attenuated influenza vaccine (LAIV3) was licensed and recommended for use in 2003 in children and adults 2-49 years of age. Post-licensure safety data have been limited, particularly in adults. Methods We searched Vaccine Adverse Event Reporting System (VAERS) for US reports after LAIV3 from July 1, 2005-June 30, 2013 (eight influenza seasons) in adults aged greater than or equal to 18 years old. We conducted descriptive analyses and clinically reviewed serious reports (i.e., death, life-threatening illness, hospitalization, prolonged hospitalization, or permanent disability) and reports of selected conditions of interest. We used empirical Bayesian data mining to identify adverse events (AEs) that were reported more frequently than expected. We calculated crude AE reporting rates to VAERS by influenza season. Results During the study period, VAERS received 1207 LAIV3 reports in adults aged 18-49 years old; 107 (8.9%) were serious, including four death reports. The most commonly reported events were expired drug administered (n=207, 17%), headache (n=192, 16%), and fever (n=133, 11%). The most common diagnostic categories for non-fatal serious reports were neurological (n=40, 39%), cardiovascular (n=14, 14%), and other non-infectious conditions (n=20, 19%). We noted a higher proportion of Guillain-Barre syndrome (GBS) and cardiovascular reports in the Department of Defense (DoD) population compared to the civilian population. Data mining detected disproportional reporting of ataxia (n=15); clinical review revealed that ataxia was a component of diverse clinical entities including GBS. Conclusions Review of VAERS reports are reassuring, the only unexpected safety concern for LAIV3 identified was a higher than expected number of GBS reports in the DoD population, which is being investigated. Reports of administration of expired LAIV3 represent administration errors and indicate the need for education, training and screening regarding the approved indications. JF - Vaccine AU - Haber, Penina AU - Moro, Pedro L AU - McNeil, Michael M AU - Lewis, Paige AU - Woo, Emily Jane AU - Hughes, Hayley AU - Shimabukuro, Tom T AD - Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention (CDC), 1600 Clifton Rd NE, Atlanta, GA 30333, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 6499 EP - 6504 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 32 IS - 48 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Vaccine safety KW - Post-licensure surveillance KW - Live attenuated influenza vaccine KW - Age KW - Bayesian analysis KW - Influenza KW - Fever KW - Guillain-Barre syndrome KW - Disabilities KW - Headache KW - Ataxia KW - Drugs KW - Mortality KW - Data processing KW - Training KW - Safety KW - Children KW - USA KW - Education KW - Reviews KW - Vaccines KW - Side effects KW - F 06905:Vaccines KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664206158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Post-licensure+surveillance+of+trivalent+live+attenuated+influenza+vaccine+in+adults%2C+United+States%2C+Vaccine+Adverse+Event+Reporting+System+%28VAERS%29%2C+July+2005-June+2013&rft.au=Haber%2C+Penina%3BMoro%2C+Pedro+L%3BMcNeil%2C+Michael+M%3BLewis%2C+Paige%3BWoo%2C+Emily+Jane%3BHughes%2C+Hayley%3BShimabukuro%2C+Tom+T&rft.aulast=Haber&rft.aufirst=Penina&rft.date=2014-11-01&rft.volume=32&rft.issue=48&rft.spage=6499&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2014.09.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 28 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Fever; Influenza; Age; Data processing; Guillain-Barre syndrome; Bayesian analysis; Reviews; Headache; Ataxia; Vaccines; Children; Drugs; Mortality; Education; Training; Disabilities; Safety; Side effects; USA DO - http://dx.doi.org/10.1016/j.vaccine.2014.09.018 ER - TY - JOUR T1 - Integrating antiretroviral therapy in methadone maintenance therapy clinics: service provider perceptions AN - 1652366448; 4644482 AB - Background: Using methadone maintenance therapy (MMT) clinics to deliver antiretroviral therapy (ART) is an effective strategy to promote treatment initiation and adherence for HIV-positive drug users. This paper describes the implementation barriers perceived by service providers for an intervention pilot designed to integrate ART services in MMT clinics. Methods: The study was conducted in six MMT clinics in Sichuan province, China. Two service providers selected from each of the six clinics underwent training in administering ART. The trained providers delivered ART-related services in their clinics. A focus group was conducted among the service providers to assess their experiences and perceived challenges in delivering integrated services. Results: Barriers at policy, institutional, provider, and client levels were identified. Policy level barriers included household registration restrictions and a lack of insurance coverage for testing expenses. Inefficient coordination between treatment sites and MMT clinics was an obstacle at the institutional level. Insufficient training and added workload were barriers at the provider level. Finally, conflict with daily dosing habits was identified as the primary reason that clients did not accept ART. Conclusion: Although integrating ART into MMT clinics is beneficial, multilevel barriers to implementation need to be addressed. This study documents the need for treatment transferability and insurance coverage, protection of client confidentiality, proper provider training, coordination with treatment sites, and individualized ART service for MMT clients. Reprinted by permission of Elsevier Science Inc. JF - International journal of drug policy AU - Li, Li AU - Lin, Chunqing AU - Cao, Xiaobin AD - aUniversity of California, Los Angeles ; Chinese Center for Disease Control and Prevention Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1066 EP - 1070 VL - 25 IS - 6 SN - 0955-3959, 0955-3959 KW - Sociology KW - Medical care KW - Health care KW - Perception KW - Training KW - Patients KW - Medical treatment KW - China KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652366448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+drug+policy&rft.atitle=Integrating+antiretroviral+therapy+in+methadone+maintenance+therapy+clinics%3A+service+provider+perceptions&rft.au=Li%2C+Li%3BLin%2C+Chunqing%3BCao%2C+Xiaobin&rft.aulast=Li&rft.aufirst=Li&rft.date=2014-11-01&rft.volume=25&rft.issue=6&rft.spage=1066&rft.isbn=&rft.btitle=&rft.title=International+journal+of+drug+policy&rft.issn=09553959&rft_id=info:doi/10.1016%2Fj.drugpo.2014.04.021 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-02-09 N1 - Last updated - 2015-02-09 N1 - SubjectsTermNotLitGenreText - 12894; 5775 13521; 7875 5775 13521; 7890 5792 10484; 9271 7890 5792 10484; 9382; 6013 6590; 93 116 30 DO - http://dx.doi.org/10.1016/j.drugpo.2014.04.021 ER - TY - GEN T1 - Leveraging birth defects surveillance data for health services research. AN - 1628527949; 25369783 JF - Birth defects research. Part A, Clinical and molecular teratology AU - Cassell, Cynthia H AU - Grosse, Scott D AU - Kirby, Russell S Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 815 EP - 821 VL - 100 IS - 11 KW - Index Medicus KW - Humans KW - Health Surveys KW - Databases, Factual KW - United States -- epidemiology KW - Health Services Research -- statistics & numerical data KW - Health Services Needs and Demand -- statistics & numerical data KW - Health Services Research -- economics KW - Congenital Abnormalities -- epidemiology KW - Epidemiological Monitoring KW - Health Services Research -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628527949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Leveraging+birth+defects+surveillance+data+for+health+services+research.&rft.au=Cassell%2C+Cynthia+H%3BGrosse%2C+Scott+D%3BKirby%2C+Russell+S&rft.aulast=Cassell&rft.aufirst=Cynthia&rft.date=2014-11-01&rft.volume=100&rft.issue=11&rft.spage=815&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23330 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-07 N1 - Date created - 2014-11-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23330 ER - TY - JOUR T1 - Effect of living conditions on biochemical and hematological parameters of the cynomolgus monkey AN - 1627699704; 4619757 AB - The cynomolgus monkey (Macaca fascicularis) has been increasingly used in biomedical research. Although living conditions affect behavioral and physiological characteristics in macaques, little data is available on how living conditions influence blood-based parameters in the cynomolgus monkey. We hypothesize that there are significant differences in serum biochemical and hematological parameters in single-caged versus socially housed cynomolgus monkeys, and that age and sex influence the effect of living conditions on these parameters. Sixty single-caged and 60 socially housed cynomolgus monkeys were segregated by age group (juvenile, adult) and sex. The effects of living condition, age, sex, and the interactions between these factors on commonly reported serum biochemical and hematological parameters were analyzed by a three-way analysis of variance (ANOVA). Then, the differences between single-caged and socially housed subjects were tested in each parameter by Student's t-test. Creatinine, glucose, triglyceride, alanine aminotransferase, red blood cell volume distribution width (SD, CV), median fluorescence reticulocyte percentage, white blood cell and basophil counts, and monocyte (count, %) were lower in single-caged subjects. Blood urea nitrogen and globulin were lower in single-caged juveniles and adults, respectively. Red blood cell count, hemoglobin, hematocrit, and neutrophil (count, %) were higher, and reticulocyte and lymphocyte (counts, %) were lower, in single-caged juveniles. Mean corpuscular hemoglobin concentration was higher in single-caged subjects (but more pronounced in adults). Total protein was higher in single-caged juvenile males and lower in single-caged adult females. Alkaline phosphatase was lower in single-caged juvenile females. Mean corpuscular hemoglobin was higher, and high fluorescence reticulocyte percentage was lower, in single-caged adult males. In conclusion, living conditions significantly affect several serum biochemical and hematological parameters in the cynomolgus monkey, and these effects vary by age and sex. As this macaque is commonly housed under different living conditions, these findings should aid researchers in avoiding inaccurate conclusions concerning this species. Am. J. Primatol. 76:1011-1024, 2014. 2014 Wiley Periodicals, Inc. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Gong, Wei AU - Ji, Yongjia AU - Fang, Liang AU - Li, Leilei AU - Melgiri, Narayan D AU - Xie, Peng AU - Xie, Liang AU - Zhou, Qinming AU - Liu, Shigang AU - Xu, Fan AU - Shively, Carol A AU - Wu, Qingyuan AD - Chongqing Medical University ; Wake Forest University ; Chinese Center For Disease Control And Prevention Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1011 EP - 1024 VL - 76 IS - 11 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Blood KW - Primatology KW - Living conditions KW - Primate behaviour KW - Females KW - Old World monkeys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627699704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Effect+of+living+conditions+on+biochemical+and+hematological+parameters+of+the+cynomolgus+monkey&rft.au=Gong%2C+Wei%3BJi%2C+Yongjia%3BFang%2C+Liang%3BLi%2C+Leilei%3BMelgiri%2C+Narayan+D%3BXie%2C+Peng%3BXie%2C+Liang%3BZhou%2C+Qinming%3BLiu%2C+Shigang%3BXu%2C+Fan%3BShively%2C+Carol+A%3BWu%2C+Qingyuan&rft.aulast=Gong&rft.aufirst=Wei&rft.date=2014-11-01&rft.volume=76&rft.issue=11&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.22285 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-11-24 N1 - Last updated - 2014-11-25 N1 - SubjectsTermNotLitGenreText - 10149; 8910 10148; 10144 10148 10149 1542 11325; 1665 1678; 7480 12162 3898; 4865 11538 DO - http://dx.doi.org/10.1002/ajp.22285 ER - TY - JOUR T1 - Antimicrobial resistance in eight US hospitals along the US-Mexico border, 2000-2006 AN - 1622605716; 20811024 AB - Antimicrobial resistance (AR) is a growing problem worldwide and international travel, cross-border migration, and antimicrobial use may contribute to the introduction or emergence of AR. We examined AR rates and trends along the US-Mexico border by analysing microbiology data from eight US hospitals in three states bordering Mexico. Microbiology data were ascertained for the years 2000-2006 and for select healthcare and community pathogens including, three Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) and three Gram-positive (Staphylococcus aureus, Enterococcus, Streptococcus pneumoniae) pathogens and 10 antimicrobial-pathogen combinations. Resistance was highest in S. aureus (oxacillin resistance 45.7%), P. aeruginosa (quinolone resistance 22.3%), and E. coli (quinolone resistance 15.6%); six (60%) of the 10 antimicrobial-pathogen combinations studied had a significantly increasing trend in resistance over the study period. Potential contributing factors in the hospital and community such as infection control practices and antimicrobial use (prescription and non-prescription) should be explored further in the US-Mexico border region. JF - Epidemiology and Infection AU - Benoit AU - Ellingson, K D AU - Waterman, Sh AU - Pearson, M L AD - Division of Healthcare Quality Promotion, National Center For Emerging & Zoonotic Infectious Diseases, CDC, Atlanta, GA, USA, bvy8@cdc.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 2378 EP - 2387 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 142 IS - 11 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts KW - Travel KW - Drug resistance KW - Quinolones KW - Infection KW - Migration KW - Escherichia coli KW - Pseudomonas aeruginosa KW - Staphylococcus aureus KW - Data processing KW - Oxacillin KW - Pathogens KW - Antimicrobial agents KW - Streptococcus pneumoniae KW - Mexico KW - Health care KW - Enterococcus KW - Klebsiella pneumoniae KW - Hospitals KW - H 12000:Epidemiology and Public Health KW - A 01350:Microbial Resistance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622605716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Antimicrobial+resistance+in+eight+US+hospitals+along+the+US-Mexico+border%2C+2000-2006&rft.au=Benoit%3BEllingson%2C+K+D%3BWaterman%2C+Sh%3BPearson%2C+M+L&rft.aulast=Benoit&rft.aufirst=&rft.date=2014-11-01&rft.volume=142&rft.issue=11&rft.spage=2378&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS095026881300318X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Number of references - 31 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Travel; Data processing; Drug resistance; Quinolones; Oxacillin; Pathogens; Infection; Migration; Antimicrobial agents; Hospitals; Health care; Streptococcus pneumoniae; Enterococcus; Escherichia coli; Staphylococcus aureus; Pseudomonas aeruginosa; Klebsiella pneumoniae; Mexico DO - http://dx.doi.org/10.1017/S095026881300318X ER - TY - JOUR T1 - Physician Survey to Determine How Dengue Is Diagnosed, Treated and Reported in Puerto Rico AN - 1622611316; 20868873 AB - Dengue is a major cause of morbidity in Puerto Rico and is well-known to its physicians. Early case identification and timely initiation of treatment for patients with severe dengue can reduce medical complications and mortality. To determine clinical management and reporting practices, and assess knowledge of dengue and its management, a survey was sent to 2,512 physicians with a medical license in Puerto Rico. Of the 2,313 physicians who received the survey, 817 (35%) completed the questionnaire. Of the respondents, 708 were currently practicing medicine; 138 were board certified (Group 1), 282 were board eligible (Group 2), and 288 had not finished residency (Group 3). Although respondents clinically diagnosed, on average, 12 cases of dengue in the preceding three months, 31% did not report any suspected cases to public health officials while about half (56%) reported all cases. Overall, 29% of respondents correctly identified early signs of shock and 48% identified severe abdominal pain and persistent vomiting as warning signs for severe dengue with the proportion of correct respondents highest in Group 1. Reportedly about sixty percent (57%) appropriately never give corticosteroids or prophylactic platelet transfusions to dengue patients. One third (30%) of respondents correctly identified administration of intravenous colloid solution as the best treatment option for dengue patients with refractory shock and elevated hematocrit after an initial trial of intravenous crystalloids, and nearly one half (46%) correctly identified administration of a blood transfusion as the best option for dengue patients with refractory shock and decreased hematocrit after a trial of intravenous crystalloids. Even though dengue has been endemic in Puerto Rico for nearly 4 decades, knowledge of dengue management is still limited, compliance with WHO treatment guidelines is suboptimal, and underreporting is significant. These findings were used to design a post graduate training course to improve the clinical management of dengue. Dengue is a major cause of morbidity in Puerto Rico and is well-known to its physicians. Early case identification and timely initiation of treatment for patients with severe dengue can reduce medical complications and mortality. We conducted a survey among physicians who practice in Puerto Rico to determine clinical management and reporting practices and assess knowledge of dengue and its management. We found that although respondents clinically diagnosed, on average, 12 cases of dengue in the preceding three months, one third did not report any suspected cases to public health officials while about half reported all cases. We found that knowledge of dengue management was limited and compliance with WHO treatment guidelines was not optimal. As other dengue endemic countries have reported similar findings, a sustained continuing medical education training initiative may be necessary to improve case detection and clinical management even in countries where the disease is common. Our findings were used to design a postgraduate training course to improve the clinical management of dengue. JF - PLoS Neglected Tropical Diseases AU - Tomashek, Kay M AU - Biggerstaff, Brad J AU - Ramos, Mary M AU - Perez-Guerra, Carmen L AU - Garcia Rivera, Enid J AU - Sun, Wellington AD - Dengue Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico Y1 - 2014/10/09/ PY - 2014 DA - 2014 Oct 09 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 8 IS - 10 SN - 1935-2727, 1935-2727 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Human diseases KW - Vomiting KW - Colloids KW - Compliance KW - Disease control KW - Pain KW - Transfusion KW - Clinical trials KW - Morbidity KW - Public health KW - Endemic species KW - Dengue KW - Hematocrit KW - Disease detection KW - Inventories KW - Mortality KW - Intravenous administration KW - Complications KW - Training KW - Guidelines KW - Corticoids KW - Education KW - Blood transfusion KW - Shock KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Platelets KW - Mortality causes KW - Q1 08604:Stock assessment and management KW - H 12000:Epidemiology and Public Health KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622611316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Physician+Survey+to+Determine+How+Dengue+Is+Diagnosed%2C+Treated+and+Reported+in+Puerto+Rico&rft.au=Tomashek%2C+Kay+M%3BBiggerstaff%2C+Brad+J%3BRamos%2C+Mary+M%3BPerez-Guerra%2C+Carmen+L%3BGarcia+Rivera%2C+Enid+J%3BSun%2C+Wellington&rft.aulast=Tomashek&rft.aufirst=Kay&rft.date=2014-10-09&rft.volume=8&rft.issue=10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003192 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Education; Endemic species; Human diseases; Colloids; Disease control; Disease detection; Mortality causes; Public health; Mortality; Inventories; Intravenous administration; Vomiting; Pain; Clinical trials; Morbidity; Corticoids; Blood transfusion; Shock; Dengue; Platelets; Hematocrit; Training; Complications; Guidelines; Compliance; Transfusion; ASW, Caribbean Sea, Greater Antilles, Puerto Rico DO - http://dx.doi.org/10.1371/journal.pntd.0003192 ER - TY - JOUR T1 - Fatal Burkholderia pseudomallei Infection Initially Reported as a Bacillus Species, Ohio, 2013 AN - 1753472890; PQ0002164933 AB - A fatal case of melioidosis was diagnosed in Ohio one month after culture results were initially reported as a Bacillus species. To identify a source of infection and assess risk in patient contacts, we abstracted patient charts; interviewed physicians and contacts; genetically characterized the isolate; performed a Burkholderia pseudomallei antibody indirect hemagglutination assay on household contacts and pets to assess seropositivity; and collected household plant, soil, liquid, and insect samples for culturing and real-time polymerase chain reaction testing. Family members and pets tested were seronegative for B. pseudomallei. Environmental samples were negative by real-time polymerase chain reaction and culture. Although the patient never traveled internationally, the isolate genotype was consistent with an isolate that originated in Southeast Asia. This investigation identified the fifth reported locally acquired non-laboratory melioidosis case in the contiguous United States. Physicians and laboratories should be aware of this potentially emerging disease and refer positive cultures to a Laboratory Response Network laboratory. JF - American Journal of Tropical Medicine and Hygiene AU - Doker, Thomas J AU - Quinn, Celia L AU - Salehi, Ellen D AU - Sherwood, Joshua J AU - Benoit, Tina J AU - Elrod, Mindy Glass AU - Gee, Jay E AU - Shadomy, Sean V AU - Bower, William A AU - Hoffmaster, Alex R AU - Walke, Henry T AU - Blaney, David D AU - DiOrio, Mary S AD - Epidemic Intelligence Service, and Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, thomas.doker@gmail.com Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 743 EP - 746 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Burkholderia pseudomallei KW - Soil KW - Pets KW - Antibodies KW - Melioidosis KW - Polymerase chain reaction KW - Genotypes KW - Infection KW - Bacillus KW - Indirect hemagglutination KW - J 02400:Human Diseases KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753472890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Fatal+Burkholderia+pseudomallei+Infection+Initially+Reported+as+a+Bacillus+Species%2C+Ohio%2C+2013&rft.au=Doker%2C+Thomas+J%3BQuinn%2C+Celia+L%3BSalehi%2C+Ellen+D%3BSherwood%2C+Joshua+J%3BBenoit%2C+Tina+J%3BElrod%2C+Mindy+Glass%3BGee%2C+Jay+E%3BShadomy%2C+Sean+V%3BBower%2C+William+A%3BHoffmaster%2C+Alex+R%3BWalke%2C+Henry+T%3BBlaney%2C+David+D%3BDiOrio%2C+Mary+S&rft.aulast=Doker&rft.aufirst=Thomas&rft.date=2014-10-01&rft.volume=91&rft.issue=4&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0172 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Soil; Antibodies; Pets; Melioidosis; Polymerase chain reaction; Genotypes; Infection; Indirect hemagglutination; Burkholderia pseudomallei; Bacillus DO - http://dx.doi.org/10.4269/ajtmh.14-0172 ER - TY - JOUR T1 - Formative Investigation of Acceptability of Typhoid Vaccine During a Typhoid Fever Outbreak in Neno District, Malawi AN - 1727695010; PQ0002164931 AB - Typhoid fever affects an estimated 22 million people annually and causes 216,000 deaths worldwide. We conducted an investigation in August and September 2010 to examine the acceptability of typhoid vaccine in Neno District, Malawi where a typhoid outbreak was ongoing. We used qualitative methods, including freelisting exercises, key informant and in-depth interviews, and group discussions. Respondents associated illness with exposure to "bad wind," and transmission was believed to be airborne. Typhoid was considered extremely dangerous because of its rapid spread, the debilitating conditions it produced, the number of related fatalities, and the perception that it was highly contagious. Respondents were skeptical about the effectiveness of water, sanitation, and hygiene (WaSH) interventions. The perceived severity of typhoid and fear of exposure, uncertainty about the effectiveness of WaSH measures, and widespread belief in the efficacy of vaccines in preventing disease resulted in an overwhelming interest in receiving typhoid vaccine during an outbreak. JF - American Journal of Tropical Medicine and Hygiene AU - Blum, Lauren S AU - Dentz, Holly AU - Chingoli, Felix AU - Chilima, Benson AU - Warne, Thomas AU - Lee, Carla AU - Hyde, Terri AU - Gindler, Jacqueline AU - Sejvar, James AU - Mintz, Eric D AD - Waterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, (NCEZID), CDC, Atlanta, Georgia, laurensblum@yahoo.com Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 729 EP - 737 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Fear KW - Disease control KW - Physical training KW - Disease transmission KW - Sanitation KW - Perception KW - Malawi KW - Vaccines KW - Typhoid fever KW - Hygiene KW - Wind KW - K 03400:Human Diseases KW - J 02400:Human Diseases KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727695010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Formative+Investigation+of+Acceptability+of+Typhoid+Vaccine+During+a+Typhoid+Fever+Outbreak+in+Neno+District%2C+Malawi&rft.au=Blum%2C+Lauren+S%3BDentz%2C+Holly%3BChingoli%2C+Felix%3BChilima%2C+Benson%3BWarne%2C+Thomas%3BLee%2C+Carla%3BHyde%2C+Terri%3BGindler%2C+Jacqueline%3BSejvar%2C+James%3BMintz%2C+Eric+D&rft.aulast=Blum&rft.aufirst=Lauren&rft.date=2014-10-01&rft.volume=91&rft.issue=4&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Disease control; Vaccines; Hygiene; Sanitation; Fear; Perception; Typhoid fever; Wind; Disease transmission; Physical training; Malawi DO - http://dx.doi.org/10.4269/ajtmh.14-0067 ER - TY - JOUR T1 - Validation of Self-Reported Smokeless Tobacco Use by Measurement of Serum Cotinine Concentration Among US Adults AN - 1701487035; PQ0001756132 AB - Although investigators have assessed the relationship between self-reported cigarette smoking and biomarker levels, the validity of self-reported information on smokeless tobacco (SLT) use is uncertain. We used aggregated data from the 2003-2004, 2005-2006, 2007-2008, and 2009-2010 administrations of the National Health and Nutrition Examination Survey (NHANES) to compare self-reported SLT use with serum concentrations of cotinine, a metabolite of nicotine, among US adults aged greater than or equal to 18 years. Receiver operating characteristic analysis was used to determine the optimal serum cotinine cutpoint for discriminating SLT users from nonusers of tobacco, and concordance analysis was used to compare self-reported SLT use with cotinine levels. Among the 30,298 adult respondents who completed the NHANES during 2003-2010, 418 reported having exclusively used SLT and no other type of tobacco (cigarettes, cigars, or pipes) during the past 5 days, while 23,457 reported not using any tobacco. The optimal cotinine cutpoint for discriminating SLT users from non-tobacco users was 3.0 ng/mL (sensitivity = 97.0%, specificity = 93.0%), which was comparable to a revised cutpoint recommended for identifying adult cigarette smokers. Concordance with cotinine was 96.4% and 93.7% for self-reported SLT use and tobacco nonuse, respectively. These findings indicate that self-reported SLT use among adults correlates highly with serum cotinine levels and that the optimal cutpoint for minimizing misclassification of self-reported use is a serum cotinine concentration of 3.0 ng/mL. JF - American Journal of Epidemiology AU - Agaku, Israel T AU - King, Brian A AD - Correspondence to Dr. Israel T. Agaku, Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS F-79, Atlanta, GA 30341., iagaku@cdc.gov Y1 - 2014/10/01/ PY - 2014 DA - 2014 Oct 01 SP - 749 EP - 754 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 180 IS - 7 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts KW - biomarkers KW - cotinine KW - epidemiologic methods KW - smokeless tobacco KW - smoking KW - snuff KW - tobacco KW - Cotinine KW - Data processing KW - Nicotine KW - Cigarette smoking KW - Tobacco KW - Metabolites KW - Nutrition KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701487035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Validation+of+Self-Reported+Smokeless+Tobacco+Use+by+Measurement+of+Serum+Cotinine+Concentration+Among+US+Adults&rft.au=Agaku%2C+Israel+T%3BKing%2C+Brian+A&rft.aulast=Agaku&rft.aufirst=Israel&rft.date=2014-10-01&rft.volume=180&rft.issue=7&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Data processing; Cotinine; Nicotine; Cigarette smoking; Tobacco; Metabolites; biomarkers; Nutrition DO - http://dx.doi.org/10.1093/aje/kwu182 ER - TY - JOUR T1 - Does every US smoker bear the same cigarette tax? AN - 1660014466; 2011-731195 AB - To evaluate state cigarette excise tax pass-through rates for selected price-minimizing strategies. Multivariate regression analysis of current smokers from a stratified, national, dual-frame telephone survey. A total of 16 542 adult current smokers aged 18 years or older. Cigarette per pack prices paid with and without coupons were obtained for pack versus carton purchase, use of generic brands versus premium brands, and purchase from Indian reservations versus outside Indian reservations. The average per pack prices paid differed substantially by price-minimizing strategy. Smokers who used any type of price-minimizing strategies paid substantially less than those who did not use these strategies (P < 0.05). Premium brand users who purchased by pack in places outside Indian reservations paid the entire amount of the excise tax, together with an additional premium of 7-10 cents per pack for every $1 increase in excise tax (pass-through rate of 1.07-1.10, P < 0.05). In contrast, carton purchasers, generic brand users or those who were likely to make their purchases on Indian reservations paid only 30-83 cents per pack for every $1 tax increase (pass-through rate of 0.30-0.83, P < 0.05). Many smokers in the United States are able to avoid the full impact of state excise tax on cost of smoking by buying cartons, using generic brands and buying from Indian reservations. Adapted from the source document. JF - Addiction AU - Xu, Xin AU - Malarcher, Ann AU - O'Halloran, Alissa AU - Kruger, Judy AD - Office on Smoking and Health National Center for Chronic Disease Prevention and Health Promotion. Centers for Disease Control and Prevention Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 1741 EP - 1749 PB - Blackwell Publishing, Oxford UK VL - 109 IS - 10 SN - 0965-2140, 0965-2140 KW - Banking and public and private finance - Taxation and tax policy KW - Business and service sector - Business finance KW - Population groups, population policy, and demographics - Demography and census KW - Social conditions and policy - Drinking, smoking, and drug addiction KW - Education and education policy - Statistics, research, research methods, and research support KW - Economic conditions and policy - Economic theory KW - Cost KW - United States KW - Taxation KW - Smoking KW - Indians Reservations KW - Prices KW - Telephone surveys KW - Adults KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660014466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Does+every+US+smoker+bear+the+same+cigarette+tax%3F&rft.au=Xu%2C+Xin%3BMalarcher%2C+Ann%3BO%27Halloran%2C+Alissa%3BKruger%2C+Judy&rft.aulast=Xu&rft.aufirst=Xin&rft.date=2014-10-01&rft.volume=109&rft.issue=10&rft.spage=1741&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12630 LA - English DB - PAIS Index N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Indians Reservations; Taxation; United States; Prices; Adults; Smoking; Telephone surveys; Cost DO - http://dx.doi.org/10.1111/add.12630 ER - TY - JOUR T1 - Molecular Epidemiology of the Pertussis Epidemic in Washington State in 2012 AN - 1622600620; 20856328 AB - Although pertussis disease is vaccine preventable, Washington State experienced a substantial rise in pertussis incidence beginning in 2011. By June 2012, the reported cases reached 2,520 (37.5 cases per 100,000 residents), a 1,300% increase compared with the same period in 2011. We assessed the molecular epidemiology of this statewide epidemic using 240 isolates collected from case patients reported from 19 of 39 Washington counties during 2012 to 2013. The typing methods included pulsed-field gel electrophoresis (PFGE), multilocus variable number tandem repeat analysis (MLVA), multilocus sequence typing (MLST), and pertactin gene (prn) mutational analysis. Using the scheme PFGE-MLVA-MLST-prn mutations-Prn deficiency, the 240 isolates comprised 65 distinct typing profiles. Thirty-one PFGE types were found, with the most common types, CDC013 (n = 51), CDC237 (n = 44), and CDC002 (n = 42), accounting for 57% of them. Eleven MLVA types were observed, mainly comprising type 27 (n = 183, 76%). Seven MLST types were identified, with the majority of the isolates typing as prn2-ptxP3-ptxA1-fim3-1 (n = 157, 65%). Four different prn mutations accounted for the 76% of isolates exhibiting pertactin deficiency. PFGE provided the highest discriminatory power (D = 0.87) and was found to be a more powerful typing method than MLVA and MLST combined (D = 0.67). This study provides evidence for the continued predominance of MLVA 27 and prn2-ptxP3-ptxA1 alleles, along with the reemergence of the fim3-1 allele. Our results indicate that the Bordetella pertussis population causing this epidemic was diverse, with a few molecular types predominating. The PFGE, MLVA, and MLST profiles were consistent with the predominate types circulating in the United States and other countries. For prn, several mutations were present in multiple molecular types. JF - Journal of Clinical Microbiology AU - Bowden, Katherine E AU - Williams, Margaret M AU - Cassiday, Pamela K AU - Milton, Andrea AU - Pawloski, Lucia AU - Harrison, Marsenia AU - Martin, Stacey W AU - Meyer, Sarah AU - Qin, Xuan AU - DeBolt, Chas AD - Centers for Disease Control and Prevention, Atlanta, Georgia, USA, mlt5@cdc.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 3549 EP - 3557 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 10 SN - 0095-1137, 0095-1137 KW - Health & Safety Science Abstracts KW - USA, Washington KW - Bordetella pertussis KW - Electrophoresis KW - Epidemiology KW - Vaccines KW - Mutation KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622600620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Molecular+Epidemiology+of+the+Pertussis+Epidemic+in+Washington+State+in+2012&rft.au=Bowden%2C+Katherine+E%3BWilliams%2C+Margaret+M%3BCassiday%2C+Pamela+K%3BMilton%2C+Andrea%3BPawloski%2C+Lucia%3BHarrison%2C+Marsenia%3BMartin%2C+Stacey+W%3BMeyer%2C+Sarah%3BQin%2C+Xuan%3BDeBolt%2C+Chas&rft.aulast=Bowden&rft.aufirst=Katherine&rft.date=2014-10-01&rft.volume=52&rft.issue=10&rft.spage=3549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01189-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Number of references - 42 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Electrophoresis; Epidemiology; Vaccines; Mutation; Bordetella pertussis; USA, Washington DO - http://dx.doi.org/10.1128/JCM.01189-14 ER - TY - RPRT T1 - CENTERS FOR DISEASE CONTROL AND PREVENTION ROYBAL CAMPUS 2025 MASTER PLAN, DEKALB COUNTY, GEORGIA. AN - 1672869421; 16245 AB - PURPOSE: A master plan to guide the future physical development of the CDCs Edward R. Roybal Campus for the planning horizon of 2015 to 2015 is proposed. The Roybal Campus is situated on 46.7 acres, just outside the city limits of the City of Atlanta in DeKalb County, Georgia. The campus is located between Interstate 85 and 20 and is located within the Clifton Corridor, which is a transportation corridor that extends along Clifton Road and includes a mix of neighborhoods, activity centers and thoroughfares within unincorporated DeKalb County, the City of Atlanta, and the City of Decatur. The Clifton Corridor represents one of the largest employment centers within the metro Atlanta area and is home to several major employers including the CDC, Emory University, Emory Healthcare, and the Veterans Affairs Medical Center. The Hartsfield-Jackson International Airport is located approximately 16 miles southwest of the campus. The Roybal Campus is located adjacent to Emory University and is surrounded by a mix of residential and institutional uses. Decatur Station, the closest MARTA station, is located approximately 2 miles southwest of the campus. The following eight Master Plan conceptual alternatives were evaluated for this final EIS: (1) No Action, (2) Increase Space Efficiency, (3a) Lab-Office Mix Moderate, (3b) Lab-Office Full-Build, (4) Office Focus, (5a) Lab Focus Moderate, (5b) Lab Focus Full-Build, and (6) Relocation. Of the eight alternatives, two alternatives were deemed viable to be carried forward in the final EIS for detailed analysis, the No Action and Lab Focus Moderate alternatives. The Lab Focus Moderate alternative, also the CDCs Preferred Alternative, includes new laboratory construction, building renovation, parking expansion, and additional improvements to campus infrastructure. The new laboratory building would measure approximately 350,000 to 450,000 gsf which would include approximately 60,000 gsf of below grade space. The new 1,600 space parking deck would be constructed in the southeastern portion of the campus, which currently consists of a surface parking lot and an existing transshipping facility. As part of the new parking deck construction, a new chilled water storage unit would be constructed in order to meet water usage reduction, energy reduction, and efficiency objectives. The No Action Alternative represented continued operation of the existing facilities at the Roybal Campus without any new construction of any major renovations of interiors or building additions over the ten-year planning period from 2015 to 2025. POSITIVE IMPACTS: Physical development of the Roybal Campus would: (1) accommodate current and future multi-program needs; (2) promote a collaborative research environment; (3) balance future development needs with site constraints and opportunities; and (4) promote overall visual and aesthetic continuity of the 2000-2009 Master Plan through the application of design guidelines for buildings. Implementation of the Preferred Alternative would increase the employee population by approximately 1,485 new occupants, from the current total of 5,308 to 6,793 in 2025. NEGATIVE IMPACTS: The Preferred Alternative would contribute to increased traffic within the Study Area which may affect fire and emergency response times. The Preferred Alternative would result in an increase in electricity, domestic water, natural gas consumption and sewage generation on campus, as well as increase the demand for steam and chilled water. JF - EPA number: 140250, Final EIS Volume I--286 pages, Volume II--612 pages, September 5, 2014 PY - 2014 KW - Urban and Social Programs KW - Air Quality KW - Biologic Assessments KW - Demolition KW - Land Use KW - Buildings KW - Cultural Resources KW - Floodplains KW - Traffic Analyses KW - Noise KW - Parking KW - Public Health KW - Research Facilities KW - Safety KW - Visual Resources KW - Water Resources KW - Wetlands KW - Georgia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1672869421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2014-09-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=CENTERS+FOR+DISEASE+CONTROL+AND+PREVENTION+ROYBAL+CAMPUS+2025+MASTER+PLAN%2C+DEKALB+COUNTY%2C+GEORGIA.&rft.title=CENTERS+FOR+DISEASE+CONTROL+AND+PREVENTION+ROYBAL+CAMPUS+2025+MASTER+PLAN%2C+DEKALB+COUNTY%2C+GEORGIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, Center for Disease Control and Prevention, Atlanta, Georgia; HHS N1 - Date revised - 2015-04-01 N1 - SuppNotes - Final. Preparation date: September 5, 2014 N1 - Last updated - 2015-04-14 ER - TY - JOUR T1 - Relationship Between Frequency and Intensity of Cigarette Smoking and TTFC/C Among Students of the GYTS in Select Countries, 2007‐2009 AN - 1748687953 AB - This study assessed the construct validity of a measure of nicotine dependence that was used in the Global Youth Tobacco Survey (GYTS). Using 2007‐2009 data from the GYTS, subjects from 6 countries were used to assess current smokers' odds of reporting time to first cigarette or craving positive (TTFC/C+) by the number of cigarette smoking days per month (DPM) and the number of cigarettes smoked per day (CPD). The percentage of GYTS smokers who reported TTFC/C+ ranged from 58.0% to 69.7%. Compared with students who smoked on 1‐2 DPM, those who smoked on 3‐9 DPM had 3 times the adjusted odds of reporting TTFC/C+. The adjusted odds of reporting TTFC/C+ were 3 to 7 times higher among those who smoked 10‐29 DPM and 6 to 20 times higher among daily smokers. Similarly, the adjusted odds of TTFC/C+ were 3‐6 times higher among those who smoked 2‐5 CPD and 6 to 20 times higher among those who smoked > 6 CPD, compared to those who smoked < 1 CPD. Associations of TTFC/C+ prevalence with both frequency and intensity of cigarette smoking provide a construct validation of the GYTS question used to assess respondents' TTFC/C status. JF - The Journal of School Health AU - Lam, Eugene AU - Giovino, Gary A AU - Shin, Mikyong AU - Lee, Kyung A AU - Rolle, Italia AU - Asma, Samira AD - Epidemic Intelligence Service, Office of Surveillance. Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention elam@cdc.gov; Department of Community Health and Health Behavior, School of Public Health and Health Professions. University at Buffalo, State University of New York ggiovino@buffalo.edu; Global Tobacco Control Branch, Office on Smoking and Health. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention fqx6@cdc.gov itr2@cdc.gov sea5@cdc.gov; Northrup Grumman Information Systems inx6@cdc.gov; Epidemic Intelligence Service, Office of Surveillance. Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 549 EP - 558 CY - Kent PB - Wiley Subscription Services, Inc. VL - 84 IS - 9 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Cigarettes KW - Construct validity KW - Craving KW - Drug dependency KW - Nicotine KW - Prevalence KW - Smokers KW - Smoking KW - Tobacco KW - Validation KW - Young people UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1748687953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=Relationship+Between+Frequency+and+Intensity+of+Cigarette+Smoking+and+TTFC%2FC+Among+Students+of+the+GYTS+in+Select+Countries%2C+2007%E2%80%902009&rft.au=Lam%2C+Eugene%3BGiovino%2C+Gary+A%3BShin%2C+Mikyong%3BLee%2C+Kyung+A%3BRolle%2C+Italia%3BAsma%2C+Samira&rft.aulast=Lam&rft.aufirst=Eugene&rft.date=2014-09-01&rft.volume=84&rft.issue=9&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12185 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-14 N1 - Last updated - 2016-05-24 DO - http://dx.doi.org/10.1111/josh.12185 ER - TY - JOUR T1 - Phylogeography of Rickettsia rickettsii Genotypes Associated with Fatal Rocky Mountain Spotted Fever AN - 1722179600; PQ0002099231 AB - Rocky Mountain spotted fever (RMSF), a tick-borne zoonosis caused by Rickettsia rickettsii, is among the deadliest of all infectious diseases. To identify the distribution of various genotypes of R. rickettsii associated with fatal RMSF, we applied molecular typing methods to samples of DNA extracted from formalin-fixed, paraffin-embedded tissue specimens obtained at autopsy from 103 case-patients from seven countries who died of RMSF. Complete sequences of one or more intergenic regions were amplified from tissues of 30 (29%) case-patients and revealed a distribution of genotypes consisting of four distinct clades, including the Flip clade, regarded previously as a non-pathogenic strain of R. rickettsii. Distinct phylogeographic patterns were identified when composite case-patient and reference strain data were mapped to the state and country of origin. The phylogeography of R. rickettsii is likely determined by ecological and environmental factors that exist independently of the distribution of a particular tick vector. JF - American Journal of Tropical Medicine and Hygiene AU - Paddock, Christopher D AU - Denison, Amy M AU - Lash, R Ryan AU - Liu, Lindy AU - Bollweg, Brigid C AU - Dahlgren, F Scott AU - Kanamura, Cristina T AU - Angerami, Rodrigo N AU - Pereira, Fabiana C AU - Martines, Roosecelis Brasil AU - Karpathy, Sandor E AD - Infectious Diseases Pathology Branch and Rickettsial Zoonoses Branch, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, cdp9@cdc.gov Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 589 EP - 597 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 3 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Autopsy KW - Data processing KW - Ixodidae KW - Nucleotide sequence KW - Ecological distribution KW - Vectors KW - Genotypes KW - Hosts KW - Environmental factors KW - North America, Rocky Mts. KW - Rocky Mountain spotted fever KW - Infectious diseases KW - DNA KW - Rickettsia rickettsii KW - Hygiene KW - Q1 08422:Environmental effects KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722179600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Phylogeography+of+Rickettsia+rickettsii+Genotypes+Associated+with+Fatal+Rocky+Mountain+Spotted+Fever&rft.au=Paddock%2C+Christopher+D%3BDenison%2C+Amy+M%3BLash%2C+R+Ryan%3BLiu%2C+Lindy%3BBollweg%2C+Brigid+C%3BDahlgren%2C+F+Scott%3BKanamura%2C+Cristina+T%3BAngerami%2C+Rodrigo+N%3BPereira%2C+Fabiana+C%3BMartines%2C+Roosecelis+Brasil%3BKarpathy%2C+Sandor+E&rft.aulast=Paddock&rft.aufirst=Christopher&rft.date=2014-09-01&rft.volume=91&rft.issue=3&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.14-0146 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Infectious diseases; Ecological distribution; Nucleotide sequence; DNA; Hosts; Genotypes; Hygiene; Environmental factors; Autopsy; Rocky Mountain spotted fever; Data processing; Vectors; Ixodidae; Rickettsia rickettsii; North America, Rocky Mts. DO - http://dx.doi.org/10.4269/ajtmh.14-0146 ER - TY - JOUR T1 - Correlates of syphilis seropositivity and risk for syphilis-associated adverse pregnancy outcomes among women attending antenatal care clinics in the Democratic Republic of Congo AN - 1717493181; PQ0002006193 AB - Screening and treatment for syphilis among pregnant women is the primary means of prevention of congenital syphilis. Sentinel surveillance for syphilis can inform these prevention efforts. We reviewed antenatal syphilis screening results to assess trends and to identify correlates of seropositivity among women attending antenatal care clinics in the Democratic Republic of Congo during 2011. Syphilis seropositivity among the 17,669 women attending the antenatal care clinics during 2011 was 4.2% (range 0.4%-16.9%). Syphilis seropositivity was significantly higher among women attending rural clinics (5.0%) as compared to urban clinics (3.0%) and those tested in antenatal care clinics in the provinces of Equateur (7.6%) and Orientale (7.7%) as compared to other provinces (p < 0.001). Based on the antenatal care syphilis seroprevalence and national pregnancy estimates, we estimate that approximately 128,591 pregnant women countrywide would have tested seropositive for syphilis during 2011. Over 85,000 adverse pregnancy outcomes would have resulted from these maternal infections, assuming prenatal syphilis diagnosis and treatment were not available. The prevalence of syphilis was highest in rural areas, but exceeded 1% in every area, indicating a need to assure screening and treatment throughout Democratic Republic of Congo. These sentinel surveillance estimates can be used to guide national congenital syphilis prevention efforts. JF - International Journal of STD & AIDS AU - Taylor, Melanie M AU - Ebrahim, Shahul AU - Abiola, Nadine AU - Kinkodi, Didine Kaba AU - Mpingulu, Minlangu AU - Kabuayi, Jean Pierre AU - Ekofo, Felly AU - Newman, Daniel R AU - Peterman, Thomas A AU - Kamb, Mary L AU - Sidibe, Kassim AD - Centers for Disease Control and Prevention, Division of STD Prevention, Atlanta, GA, USA, MDT7@CDC.GOV PY - 2014 SP - 716 EP - 725 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 25 IS - 10 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Microbiology Abstracts B: Bacteriology; Risk Abstracts; Virology & AIDS Abstracts KW - Syphilis KW - congenital syphilis KW - antenatal care KW - Democratic Republic of Congo KW - STD KW - STI KW - screening KW - prevention KW - seroprevalence KW - Risk assessment KW - Acquired immune deficiency syndrome KW - Prenatal experience KW - Infection KW - Pregnancy KW - Prevention KW - Reviews KW - Treponema pallidum KW - Females KW - Sexually transmitted diseases KW - Rural areas KW - V 22360:AIDS and HIV KW - R2 23060:Medical and environmental health KW - J 02400:Human Diseases KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717493181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Correlates+of+syphilis+seropositivity+and+risk+for+syphilis-associated+adverse+pregnancy+outcomes+among+women+attending+antenatal+care+clinics+in+the+Democratic+Republic+of+Congo&rft.au=Taylor%2C+Melanie+M%3BEbrahim%2C+Shahul%3BAbiola%2C+Nadine%3BKinkodi%2C+Didine+Kaba%3BMpingulu%2C+Minlangu%3BKabuayi%2C+Jean+Pierre%3BEkofo%2C+Felly%3BNewman%2C+Daniel+R%3BPeterman%2C+Thomas+A%3BKamb%2C+Mary+L%3BSidibe%2C+Kassim&rft.aulast=Taylor&rft.aufirst=Melanie&rft.date=2014-09-01&rft.volume=25&rft.issue=10&rft.spage=716&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462413518194 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Reviews; Infection; Syphilis; Pregnancy; Risk assessment; Acquired immune deficiency syndrome; Prevention; Prenatal experience; Females; Sexually transmitted diseases; Rural areas; Treponema pallidum DO - http://dx.doi.org/10.1177/0956462413518194 ER - TY - JOUR T1 - Fall Prevention Research and Practice: A Total Worker Safety Approach AN - 1627956581; 20906967 AB - Slips, trips, and falls (STF) represent a serious hazard to workers and occupants in many industries, homes, and communities. Often, the cause of a STF incident is multifactorial, encompassing human, environmental, and task risk factors. A STF-related disability can greatly diminish the occupational capability and quality of life of individuals in both the workplace and the home. Countering STF hazards and risks both on and off the job and on all aspects of control measures is a "total worker safety" matter, a challenging yet tangible undertaking. As the federal organization responsible for conducting research for the prevention of work-related injuries in the United States, the National Institute for Occupational Safety and Health (NIOSH) has been conducting research on STF controls for some decades. Many NIOSH research outcomes have been utilized for STF prevention in workplaces, with potential for prevention in homes as well. This paper summarizes the concept of total worker safety for STF control, NIOSH priority research goals, major activities, and accomplishments, and some emerging issues on STF. The strategic planning process for the NIOSH research goals and some identified research focuses are applicable to the development and implementation of global STF research goals. JF - Industrial Health AU - HSIAO, Hongwei AD - National Institute for Occupational Safety and Health, USA, hxh4@cdc.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 381 EP - 392 PB - National Institute of Industrial Health. Japan., 21-1 Nagao 6-chome Kawasaki-shi 214-0023 Kanagawa-ken Japan VL - 52 IS - 5 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Falls KW - Construction KW - Healthcare KW - Trade KW - Human characteristics KW - Public safety KW - Control measure KW - USA KW - Prevention KW - Injuries KW - Risk factors KW - Disabilities KW - Occupational safety KW - Safety KW - Priorities KW - Quality of life KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627956581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Fall+Prevention+Research+and+Practice%3A+A+Total+Worker+Safety+Approach&rft.au=HSIAO%2C+Hongwei&rft.aulast=HSIAO&rft.aufirst=Hongwei&rft.date=2014-09-01&rft.volume=52&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Disabilities; Risk factors; Safety; Occupational safety; Priorities; Quality of life; USA ER - TY - JOUR T1 - Increase in anti-tuberculosis drug resistance in Botswana: results from the fourth National Drug Resistance Survey AN - 1566859538; 20756810 AB - SETTING: Although approximately 0.5 million cases of multidrug-resistant tuberculosis (MDR-TB) occur globally each year, surveillance data are limited. Botswana is one of the few high TB burden countries to have carried out multiple anti-tuberculosis drug resistance surveys (in 1995-1996,1999 and 2002). OBJECTIVE: In 2007-2008, we conducted the fourth national survey of anti-tuberculosis drug resistance in Botswana to assess anti-tuberculosis drug resistance, including trends over time. In the previous survey, 0.8% (95%CI 0.4-1.5) of new patients and 10.4% (95%CI 5.6-17.3) of previously treated patients had MDR-TB. DESIGN: During the survey period, eligible specimens from all new sputum-smear positive TB patients and from all TB patients with history of previous anti-tuberculosis treatment underwent mycobacterial culture and anti-tuberculosis drug susceptibility testing (DST). RESULTS: Of 924 new TB patients and 137 with previous anti-tuberculosis treatment with DST results, respectively 23 (2.5%, 95%CI 1.6-3.7) and 9 (6.6%, 95%CI 3.3-11.7) had MDR-TB. The proportion of new TB patients with MDR-TB has tripled in Botswana since the previous survey. CONCLUSION: Combatting drug-resistant TB will require the scale-up of MDR-TB diagnosis and treatment to prevent the transmission of MDR-TB and strengthening of general TB control to prevent the emergence of resistance. JF - International Journal of Tuberculosis and Lung Disease AU - Menzies, H J AU - Moalosi, G AU - Anisimova, V AU - Gammino, V AU - Sentie, C AU - Bachhuber, M A AU - Bile, E AU - Radisowa, K AU - Kachuwaire, O AU - Basotli, J AD - US Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, hmenzies@cdc.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1026 EP - 1033 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 18 IS - 9 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - tuberculosis KW - drug resistance KW - surveillance KW - Data processing KW - Mycobacterium KW - Drug resistance KW - Lung diseases KW - Tuberculosis KW - Drug development KW - Drugs KW - Disease transmission KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566859538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Increase+in+anti-tuberculosis+drug+resistance+in+Botswana%3A+results+from+the+fourth+National+Drug+Resistance+Survey&rft.au=Menzies%2C+H+J%3BMoalosi%2C+G%3BAnisimova%2C+V%3BGammino%2C+V%3BSentie%2C+C%3BBachhuber%2C+M+A%3BBile%2C+E%3BRadisowa%2C+K%3BKachuwaire%2C+O%3BBasotli%2C+J&rft.aulast=Menzies&rft.aufirst=H&rft.date=2014-09-01&rft.volume=18&rft.issue=9&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.13.0749 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Data processing; Drug resistance; Lung diseases; Drug development; Tuberculosis; Drugs; Disease transmission; Mycobacterium DO - http://dx.doi.org/10.5588/ijtld.13.0749 ER - TY - JOUR T1 - In Vitro Efficacy of Brincidofovir against Variola Virus AN - 1566849374; 20698191 AB - Brincidofovir (CMX001), a lipid conjugate of the acyclic nucleotide phosphonate cidofovir, is under development for smallpox treatment using "the Animal Rule," established by the FDA in 2002. Brincidofovir reduces mortality caused by orthopoxvirus infection in animal models. Compared to cidofovir, brincidofovir has increased potency, is administered orally, and shows no evidence of nephrotoxicity. Here we report that the brincidofovir half-maximal effective concentration (EC50) against five variola virus strains in vitro averaged 0.11 mu M and that brincidofovir was therefore nearly 100-fold more potent than cidofovir. JF - Antimicrobial Agents & Chemotherapy AU - Olson, Victoria A AU - Smith, Scott K AU - Foster, Scott AU - Li, Yu AU - Lanier, E Randall AU - Gates, Irina AU - Trost, Lawrence C AU - Damon, Inger K AD - Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Poxvirus and Rabies Branch, Atlanta, Georgia, USA, iad7@cdc.gov. Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 5570 EP - 5571 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 9 SN - 0066-4804, 0066-4804 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cidofovir KW - Smallpox KW - Orthopoxvirus KW - Mortality KW - phosphonates KW - Lipids KW - Animal models KW - Infection KW - Nucleotides KW - Variola virus KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566849374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=In+Vitro+Efficacy+of+Brincidofovir+against+Variola+Virus&rft.au=Olson%2C+Victoria+A%3BSmith%2C+Scott+K%3BFoster%2C+Scott%3BLi%2C+Yu%3BLanier%2C+E+Randall%3BGates%2C+Irina%3BTrost%2C+Lawrence+C%3BDamon%2C+Inger+K&rft.aulast=Olson&rft.aufirst=Victoria&rft.date=2014-09-01&rft.volume=58&rft.issue=9&rft.spage=5570&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02814-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 13 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Smallpox; Cidofovir; Mortality; phosphonates; Lipids; Animal models; Infection; Nucleotides; Orthopoxvirus; Variola virus DO - http://dx.doi.org/10.1128/AAC.02814-14 ER - TY - JOUR T1 - Comprehensive Comparison of Cultivable Norovirus Surrogates in Response to Different Inactivation and Disinfection Treatments AN - 1566848933; 20698331 AB - Human norovirus is the leading cause of epidemic and sporadic acute gastroenteritis. Since no cell culture method for human norovirus exists, cultivable surrogate viruses (CSV), including feline calicivirus (FCV), murine norovirus (MNV), porcine enteric calicivirus (PEC), and Tulane virus (TuV), have been used to study responses to inactivation and disinfection methods. We compared the levels of reduction in infectivities of CSV and Aichi virus (AiV) after exposure to extreme pHs, 56 degree C heating, alcohols, chlorine on surfaces, and high hydrostatic pressure (HHP), using the same matrix and identical test parameters for all viruses, as well as the reduction of human norovirus RNA levels under these conditions. At pH 2, FCV was inactivated by 6 log10 units, whereas MNV, TuV, and AiV were resistant. All CSV were completely inactivated at 56 degree C within 20 min. MNV was inactivated 5 log10 units by alcohols, in contrast to 2 and 3 log10 units for FCV and PEC, respectively. TuV and AiV were relatively insensitive to alcohols. FCV was reduced 5 log10 units by 1,000 ppm chlorine, in contrast to 1 log10 unit for the other CSV. All CSV except FCV, when dried on stainless steel surfaces, were insensitive to 200 ppm chlorine. HHP completely inactivated FCV, MNV, and PEC at greater than or equal to 300 MPa, and TuV at 600 MPa, while AiV was completely resistant to HHP up to 800 MPa. By reverse transcription-quantitative PCR (RT-qPCR), genogroup I (GI) noroviruses were more sensitive than GII noroviruses to alcohols, chlorine, and HHP. Although inactivation profiles were variable for each treatment, TuV and MNV were the most resistant CSV overall and therefore are the best candidates for studying the public health outcomes of norovirus infections. JF - Applied and Environmental Microbiology AU - Cromeans, Theresa AU - Park, Geun Woo AU - Costantini, Veronica AU - Lee, David AU - Wang, Qiuhong AU - Farkas, Tibor AU - Lee, Alvin AU - Vinje, Jan AD - Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA, jvinje@cdc.gov. PY - 2014 SP - 5743 EP - 5751 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 18 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Disinfection KW - Aichi virus KW - Porcine enteric calicivirus KW - Epidemics KW - Chlorine KW - Norovirus KW - Cell culture KW - Infection KW - Public health KW - Infectivity KW - RNA KW - Feline calicivirus KW - alcohols KW - Polymerase chain reaction KW - Gastroenteritis KW - Pressure KW - pH effects KW - stainless steel KW - A 01340:Antibiotics & Antimicrobials KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566848933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Comprehensive+Comparison+of+Cultivable+Norovirus+Surrogates+in+Response+to+Different+Inactivation+and+Disinfection+Treatments&rft.au=Cromeans%2C+Theresa%3BPark%2C+Geun+Woo%3BCostantini%2C+Veronica%3BLee%2C+David%3BWang%2C+Qiuhong%3BFarkas%2C+Tibor%3BLee%2C+Alvin%3BVinje%2C+Jan&rft.aulast=Cromeans&rft.aufirst=Theresa&rft.date=2014-09-01&rft.volume=80&rft.issue=18&rft.spage=5743&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01532-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 72 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Disinfection; Epidemics; Chlorine; Cell culture; Infection; Public health; Infectivity; RNA; alcohols; Polymerase chain reaction; Pressure; Gastroenteritis; pH effects; stainless steel; Aichi virus; Porcine enteric calicivirus; Feline calicivirus; Norovirus DO - http://dx.doi.org/10.1128/AEM.01532-14 ER - TY - JOUR T1 - Influenza Virus Infectivity and Virulence following Ocular-Only Aerosol Inoculation of Ferrets AN - 1566847462; 20698537 AB - Respiratory pathogens have traditionally been studied by examining the exposure and infection of respiratory tract tissues. However, these studies typically overlook the role of ocular surfaces, which represent both a potential site of virus replication and a portal of entry for the establishment of a respiratory infection. To model transocular virus entry in a mammalian species, we established a novel inoculation method that delivers an aerosol inoculum exclusively to the ferret ocular surface. Using influenza virus as a representative respiratory pathogen, we found that both human and avian viruses mounted productive respiratory infections in ferrets following ocular-only aerosol inoculation, and we demonstrated that H5N1 virus can result in a fatal infection at doses below 10 PFU or with exposure times as short as 2 min. Ferrets inoculated by the ocular aerosol route with an avian (H7N7, H7N9) or human (H1N1, H3N2v) virus were capable of transmitting the virus to naive animals in direct-contact or respiratory-droplet models, respectively. Our results reveal that ocular-only exposure to virus-containing aerosols constitutes a valid exposure route for a potentially fatal respiratory infection, even for viruses that do not demonstrate an ocular tropism, underscoring the public health implications of ocular exposure in clinical or occupational settings. IMPORTANCE In the absence of eye protection, the human ocular surface remains vulnerable to infection with aerosolized respiratory viruses. In this study, we present a way to inoculate laboratory mammals that excludes respiratory exposure, infecting ferrets only by ocular exposure to influenza virus-containing aerosols. This study demonstrates that the use of respiratory protection alone does not fully protect against influenza virus exposure, infection, and severe disease. JF - Journal of Virology AU - Belser, Jessica A AU - Gustin, Kortney M AU - Katz, Jacqueline M AU - Maines, Taronna R AU - Tumpey, Terrence M Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 9647 EP - 9654 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 88 IS - 17 SN - 0022-538X, 0022-538X KW - Ermines KW - Ferrets KW - Minks KW - Weasels KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Mammals KW - Eye KW - Viruses KW - Infection KW - Models KW - Public health KW - Virulence KW - Influenza KW - Mustela KW - Inoculum KW - Vulnerability KW - Occupational exposure KW - Respiratory tract KW - Aerosols KW - Replication KW - Tropism KW - Pathogens KW - Respiratory tract diseases KW - Infectivity KW - Influenza virus KW - Inoculation KW - V 22320:Replication KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566847462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Influenza+Virus+Infectivity+and+Virulence+following+Ocular-Only+Aerosol+Inoculation+of+Ferrets&rft.au=Belser%2C+Jessica+A%3BGustin%2C+Kortney+M%3BKatz%2C+Jacqueline+M%3BMaines%2C+Taronna+R%3BTumpey%2C+Terrence+M&rft.aulast=Belser&rft.aufirst=Jessica&rft.date=2014-09-01&rft.volume=88&rft.issue=17&rft.spage=9647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01067-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 27 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Aerosols; Eye; Replication; Tropism; Pathogens; Infection; Public health; Models; Influenza; Virulence; Respiratory tract diseases; Infectivity; Inoculation; Inoculum; Occupational exposure; Mammals; Viruses; Vulnerability; Respiratory tract; Influenza virus; Mustela DO - http://dx.doi.org/10.1128/JVI.01067-14 ER - TY - JOUR T1 - Evaluation of the Effect of Host Immune Status on Short-Term Yersinia pestis Infection in Fleas With Implications for the Enzootic Host Model for Maintenance of Y. pestis During Interepizootic Periods AN - 1566838193; 20736299 AB - Plague, a primarily flea-borne disease caused by Yersinia pestis, is characterized by rapidly spreading epizootics separated by periods of quiescence. Little is known about how and where Y. pestis persists between epizootics. It is commonly proposed, however, that Y. pestis is maintained during interepizootic periods in enzootic cycles involving flea vectors and relatively resistant host populations. According to this model, while susceptible individuals serve as infectious sources for feeding fleas and subsequently die of infection, resistant hosts survive infection, develop antibodies to the plague bacterium, and continue to provide bloodmeals to infected fleas. For Y. pestis to persist under this scenario, fleas must remain infected after feeding on hosts carrying antibodies to Y. pestis. Studies of other vector-borne pathogens suggest that host immunity may negatively impact pathogen survival in the vector. Here, we report infection rates and bacterial loads for fleas (both Xenopsylla cheopis (Rothschild) and Oropsylla montana (Baker)) that consumed an infectious bloodmeal and subsequently fed on an immunized or age-matched naive mouse. We demonstrate that neither the proportion of infected fleas nor the bacterial loads in infected fleas were significantly lower within 3 d of feeding on immunized versus naive mice. Our findings thus provide support for one assumption underlying the enzootic host model of interepizootic maintenance of Y. Pestis. JF - Journal of Medical Entomology AU - Graham, Christine B AU - Woods, Michael E AU - Vetter, Sara M AU - Petersen, Jeannine M AU - Montenieri, John A AU - Holmes, Jennifer L AU - Maes, Sarah E AU - Bearden, Scott W AU - Gage, kenneth L AU - Eisen, Rebecca J AD - Bacterial Diseases Branch, Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, hyb4@cdc.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1079 EP - 1086 PB - Entomological Society of America, 9301 Annapolis Rd. Lanham MD 20706 United States VL - 51 IS - 5 SN - 0022-2585, 0022-2585 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts KW - Yersinia pestis KW - plague KW - flea KW - enzootic KW - Immune status KW - Feeding KW - Spreading KW - Animal models KW - Survival KW - Vectors KW - Epizootics KW - Immunity KW - Pathogens KW - Infection KW - Models KW - Xenopsylla cheopis KW - Antibodies KW - Plague KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566838193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Entomology&rft.atitle=Evaluation+of+the+Effect+of+Host+Immune+Status+on+Short-Term+Yersinia+pestis+Infection+in+Fleas+With+Implications+for+the+Enzootic+Host+Model+for+Maintenance+of+Y.+pestis+During+Interepizootic+Periods&rft.au=Graham%2C+Christine+B%3BWoods%2C+Michael+E%3BVetter%2C+Sara+M%3BPetersen%2C+Jeannine+M%3BMontenieri%2C+John+A%3BHolmes%2C+Jennifer+L%3BMaes%2C+Sarah+E%3BBearden%2C+Scott+W%3BGage%2C+kenneth+L%3BEisen%2C+Rebecca+J&rft.aulast=Graham&rft.aufirst=Christine&rft.date=2014-09-01&rft.volume=51&rft.issue=5&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Entomology&rft.issn=00222585&rft_id=info:doi/10.1603%2FME12236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 54 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Immune status; Feeding; Spreading; Animal models; Vectors; Survival; Epizootics; Pathogens; Immunity; Infection; Models; Antibodies; Plague; Xenopsylla cheopis; Yersinia pestis DO - http://dx.doi.org/10.1603/ME12236 ER - TY - JOUR T1 - CDC Pregnancy Flu Line: Monitoring Severe Illness Among Pregnant Women with Influenza AN - 1566831045; 20672283 AB - The Centers for Disease Control and Prevention implemented the Pregnancy Flu Line (PFL) during the influenza A(H1N1)pdm09 (pH1N1) pandemic and continued operation through the 2010-2011 influenza season to collect reports of intensive care unit (ICU) admissions and deaths among pregnant women with influenza. The system documented the severe impact of influenza on pregnant women during both seasons with 181 ICU/survivals and 37 deaths reported during the 2009 fall pandemic wave and 69 ICU/survivals and ten deaths reported in the subsequent influenza season (2010-2011). A health department survey suggests PFL participants perceived public health benefits and minimum time burdens. JF - Maternal and Child Health Journal AU - Ailes, Elizabeth C AU - Newsome, Kimberly AU - Williams, Jennifer L AU - McIntyre, Anne F AU - Jamieson, Denise J AU - Finelli, Lyn AU - Honein, Margaret A AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, MS E-86, Atlanta, GA, 30333, USA, kan3@cdc.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1578 EP - 1582 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 18 IS - 7 SN - 1092-7875, 1092-7875 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Mortality KW - Disease control KW - Survival KW - Pregnancy KW - Public health KW - Influenza KW - Prevention KW - pandemics KW - Intensive care units KW - Perception KW - Waves KW - Females KW - H 12000:Epidemiology and Public Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566831045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+Child+Health+Journal&rft.atitle=CDC+Pregnancy+Flu+Line%3A+Monitoring+Severe+Illness+Among+Pregnant+Women+with+Influenza&rft.au=Ailes%2C+Elizabeth+C%3BNewsome%2C+Kimberly%3BWilliams%2C+Jennifer+L%3BMcIntyre%2C+Anne+F%3BJamieson%2C+Denise+J%3BFinelli%2C+Lyn%3BHonein%2C+Margaret+A&rft.aulast=Ailes&rft.aufirst=Elizabeth&rft.date=2014-09-01&rft.volume=18&rft.issue=7&rft.spage=1578&rft.isbn=&rft.btitle=&rft.title=Maternal+and+Child+Health+Journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-013-1415-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 12 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Influenza; pandemics; Intensive care units; Disease control; Survival; Waves; Public health; Pregnancy; Mortality; Prevention; Perception; Females DO - http://dx.doi.org/10.1007/s10995-013-1415-6 ER - TY - JOUR T1 - Differences in risk factors for second and third degree hypospadias in the national birth defects prevention study. AN - 1563993339; 25181604 AB - Hypospadias is a frequent birth defect with three phenotypic subtypes. With data from the National Birth Defects Prevention Study, a large, multi-state, population-based, case-control study, we compared risk factors for second and third degree hypospadias. A wide variety of data on maternal and pregnancy-related risk factors for isolated second and third degree hypospadias was collected by means of computer-assisted telephone interviews to identify potential etiological differences between the two phenotypes. Logistic regression was used to calculate odds ratios including a random effect by study center. In total, 1547 second degree cases, 389 third degree cases, and 5183 male controls were included in our study. Third degree cases were more likely to have a non-Hispanic black or Asian/Pacific Islander mother, be delivered preterm, have a low birth weight, be small for gestational age, and be conceived with fertility treatments than second degree cases and controls. Associations with both second and third degree hypospadias were observed for maternal age, family history, parity, plurality, and hypertension during pregnancy. Risk estimates were generally higher for third degree hypospadias except for family history. Most risk factors were associated with both or neither phenotype. Therefore, it is likely that the underlying mechanism is at least partly similar for both phenotypes. However, some associations were different between second and third degree hypospadias, and went in opposite directions for second and third degree hypospadias for Asian/Pacific Islander mothers. Effect estimates for subtypes of hypospadias may be over- or underestimated in studies without stratification by phenotype. © 2014 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Woud, Sander Groen In 't AU - van Rooij, Iris A L M AU - van Gelder, Marleen M H J AU - Olney, Richard S AU - Carmichael, Suzan L AU - Roeleveld, Nel AU - Reefhuis, Jennita AU - National Birth Defects Prevention Study AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia; Department for Health Evidence, Radboud university medical center, Nijmegen, The Netherlands. ; National Birth Defects Prevention Study Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 703 EP - 711 VL - 100 IS - 9 KW - Index Medicus KW - pregnancy KW - birth defects KW - hypospadias KW - risk factors KW - Netherlands -- epidemiology KW - Odds Ratio KW - Infant, Low Birth Weight KW - Humans KW - Oceanic Ancestry Group KW - Infant, Newborn KW - Infant, Premature KW - Pregnancy KW - Phenotype KW - Asian Continental Ancestry Group KW - Logistic Models KW - Risk Factors KW - Adult KW - Health Surveys KW - Case-Control Studies KW - United States -- epidemiology KW - Female KW - Male KW - Hypospadias -- classification KW - Hypertension, Pregnancy-Induced -- ethnology KW - Hypospadias -- ethnology KW - Hypertension, Pregnancy-Induced -- epidemiology KW - Hypospadias -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1563993339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Differences+in+risk+factors+for+second+and+third+degree+hypospadias+in+the+national+birth+defects+prevention+study.&rft.au=Woud%2C+Sander+Groen+In+%27t%3Bvan+Rooij%2C+Iris+A+L+M%3Bvan+Gelder%2C+Marleen+M+H+J%3BOlney%2C+Richard+S%3BCarmichael%2C+Suzan+L%3BRoeleveld%2C+Nel%3BReefhuis%2C+Jennita%3BNational+Birth+Defects+Prevention+Study&rft.aulast=Woud&rft.aufirst=Sander+Groen+In&rft.date=2014-09-01&rft.volume=100&rft.issue=9&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23296 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-21 N1 - Date created - 2014-09-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Birth Defects Res A Clin Mol Teratol. 2012 Jul;94(7):499-510 [22678668] Public Health Rep. 2001;116 Suppl 1:32-40 [11889273] J Urol. 2002 Mar;167(3):1423-7 [11832761] BJU Int. 2013 Jul;112(1):121-8 [23305310] Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):193-201 [12797461] Epidemiology. 2003 Nov;14(6):701-6 [14569186] Placenta. 2004 Feb-Mar;25(2-3):127-39 [14972445] J Urol. 1979 Apr;121(4):474-7 [439223] J Med Genet. 1990 Sep;27(9):559-63 [2231648] Epidemiol Rev. 1990;12:29-40 [2286224] Obstet Gynecol. 1996 Feb;87(2):163-8 [8559516] Pediatrics. 1997 Nov;100(5):831-4 [9346983] J Urol. 1998 Dec;160(6 Pt 1):2197-9 [9817368] Environ Health Perspect. 1999 Apr;107(4):297-302 [10090709] J Androl. 2005 Mar-Apr;26(2):163-8 [15713818] Pediatrics. 2005 Apr;115(4):e495-9 [15741350] J Urol. 2005 Oct;174(4 Pt 2):1544-8; discussion 1548 [16148649] Birth Defects Res A Clin Mol Teratol. 2006 Apr;76(4):249-52 [16586447] Paediatr Perinat Epidemiol. 2007 May;21(3):210-8 [17439529] Eur J Pediatr. 2007 Jul;166(7):671-8 [17103190] Birth Defects Res A Clin Mol Teratol. 2008 Jan;82(1):34-40 [18022875] Am J Epidemiol. 2008 Feb 1;167(3):251-6 [18042671] J Pediatr Psychol. 2008 Jun;33(5):520-35 [18056145] Environ Health Perspect. 2008 Aug;116(8):1071-6 [18709149] Birth Defects Res A Clin Mol Teratol. 2009 Jul;85(7):621-8 [19215015] Am J Med Genet A. 2010 Jan;152A(1):75-83 [20014131] BJU Int. 2010 Jan;105(2):254-62 [19751252] Hum Reprod. 2011 Feb;26(2):451-7 [21112952] Urology. 2011 Mar;77(3):716-20 [20970827] Hum Reprod Update. 2012 May-Jun;18(3):260-83 [22371315] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23296 ER - TY - JOUR T1 - Nocardia vulneris sp. nov., isolated from wounds of human patients in North America AN - 1560120013; 20528095 AB - Nocardia species are ubiquitous in the environment with an increasing number of species isolated from clinical sources. From 2005 to 2009, eight isolates (W9042, W9247, W9290, W9319, W9846, W9851 super(T), W9865, and W9908) were obtained from eight patients from three states in the United States and Canada; all were from males ranging in age from 47 to 81 years old; and all were obtained from finger (n = 5) or leg (n = 3) wounds. Isolates were characterized by polyphasic analysis using molecular, phenotypic, morphologic and chemotaxonomic methods. Sequence analysis of 16S rRNA gene sequences showed the eight isolates are 100 % identical to each other and belong in the genus Nocardia. The nearest phylogenetically related neighbours were found to be the type strains for Nocardia altamirensis (99.33 % sequence similarity), Nocardia brasiliensis (99.37 %), Nocardia iowensis (98.95 %) and Nocardia tenerifensis (98.44 %). The G+C content of isolate W9851 super(T) was determined to be 68.4 mol %. The DNA-DNA relatedness between strain W9851 super(T) and the N. brasiliensis type strain was 72.8 % and 65.8 % when measured in the laboratory and in silico from genome sequences, respectively, and 95.6 % ANI. Whole-cell peptidoglycan was found to contain meso-diaminopimelic acid; MK-8-(H sub(4)) sub( omega -cyc) was identified as the major menaquinone; the major fatty acids were identified as C sub(16:0), 10 Me C sub(18:0), and C sub(18:1 w9c), the predominant phospholipids were found to include diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol and phosphatidylinositol mannosides; whole-cell sugars detected were arabinose and galactose; and mycolic acids ranging from 38 to 60 carbon atoms were found to be present. These chemotaxonomic analyses are consistent with assignment of the isolates to the genus Nocardia. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectra of the clinical isolates showed genus and species level profiles that were different from other Nocardia species. All isolates were resistant to ciprofloxacin, clarithromycin and imipenem but were susceptible to amikacin, amoxicillin/clavulanate, linezolid and trimethoprim/sulfamethoxazole. The results of our polyphasic analysis suggest the new isolates obtained from wound infections represent a novel species within the genus Nocardia, for which the name Nocardia vulneris sp. nov. is proposed, with strain W9851 super(T) (= DSM 45737 super(T) = CCUG 62683 super(T) = NBRC 108936 super(T)) as the type strain. JF - Antonie Van Leeuwenhoek AU - Lasker, Brent A AU - Bell, Melissa AU - Klenk, Hans-Peter AU - Sproer, Cathrin AU - Schumann, Peter AU - Brown, June M AD - Bacterial Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Disease, Centers for Disease Control and Prevention, Building 17, Room 2025, Mailstop G-11, 1600 Clifton Road, Atlanta, GA, 30333, USA, blasker@cdc.gov Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 543 EP - 553 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 106 IS - 3 SN - 0003-6072, 0003-6072 KW - Microbiology Abstracts B: Bacteriology KW - Galactose KW - Trimethoprim KW - Age KW - Amikacin KW - phosphatidylinositol KW - Diphosphatidylglycerol KW - peptidoglycans KW - Mycolic acids KW - Flight KW - Ciprofloxacin KW - Clarithromycin KW - Carbon KW - Linezolid KW - Phospholipids KW - Clinical isolates KW - Phylogeny KW - Sugar KW - Amoxicillin KW - Sulfamethoxazole KW - Nocardia brasiliensis KW - Wounds KW - Finger KW - Imipenem KW - Leg KW - Menaquinones KW - Wound infection KW - Fatty acids KW - Lasers KW - phosphatidylethanolamine KW - rRNA 16S KW - New species KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560120013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antonie+Van+Leeuwenhoek&rft.atitle=Nocardia+vulneris+sp.+nov.%2C+isolated+from+wounds+of+human+patients+in+North+America&rft.au=Lasker%2C+Brent+A%3BBell%2C+Melissa%3BKlenk%2C+Hans-Peter%3BSproer%2C+Cathrin%3BSchumann%2C+Peter%3BBrown%2C+June+M&rft.aulast=Lasker&rft.aufirst=Brent&rft.date=2014-09-01&rft.volume=106&rft.issue=3&rft.spage=543&rft.isbn=&rft.btitle=&rft.title=Antonie+Van+Leeuwenhoek&rft.issn=00036072&rft_id=info:doi/10.1007%2Fs10482-014-0226-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 40 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Galactose; Age; Trimethoprim; Amikacin; phosphatidylinositol; Diphosphatidylglycerol; peptidoglycans; Mycolic acids; Flight; Clarithromycin; Ciprofloxacin; Carbon; Linezolid; Phospholipids; Phylogeny; Clinical isolates; Sugar; Amoxicillin; Sulfamethoxazole; Imipenem; Finger; Wounds; Leg; Wound infection; Menaquinones; Fatty acids; Lasers; phosphatidylethanolamine; rRNA 16S; New species; Nocardia brasiliensis DO - http://dx.doi.org/10.1007/s10482-014-0226-0 ER - TY - JOUR T1 - Developing a systematic approach to safer medication use during pregnancy: summary of a Centers for Disease Control and Prevention--convened meeting. AN - 1558526278; 24881821 AB - To address information gaps that limit informed clinical decisions on medication use in pregnancy, the Centers for Disease Control and Prevention (CDC) solicited expert input on a draft prototype outlining a systematic approach to evaluating the quality and strength of existing evidence for associated risks. The draft prototype outlined a process for the systematic review of available evidence and deliberations by a panel of experts to inform clinical decision making for managing health conditions in pregnancy. At an expert meeting convened by the CDC in January 2013, participants divided into working groups discussed decision points within the prototype. This report summarizes their discussions of best practices for formulating an expert review process, developing evidence summaries and treatment guidance, and disseminating information. There is clear recognition of current knowledge gaps and a strong collaboration of federal partners, academic experts, and professional organizations willing to work together toward safer medication use during pregnancy. Published by Elsevier Inc. JF - American journal of obstetrics and gynecology AU - Broussard, Cheryl S AU - Frey, Meghan T AU - Hernandez-Diaz, Sonia AU - Greene, Michael F AU - Chambers, Christina D AU - Sahin, Leyla AU - Collins Sharp, Beth A AU - Honein, Margaret A AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: cbroussard@cdc.gov. ; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA; Oak Ridge Institute for Science and Education, Oak Ridge, TN. ; Harvard School of Public Health, Boston, MA. ; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School and Massachusetts General Hospital, Boston, MA. ; Departments of Pediatrics and Family and Preventive Medicine, University of California, San Diego, La Jolla, CA. ; Pediatric and Maternal Health Staff, Maternal Health Team, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD. ; Agency for Healthcare Research and Quality, Rockville, MD. ; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 208 EP - 214.e1 VL - 211 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - teratogens KW - medications KW - Centers for Disease Control and Prevention KW - pregnancy KW - expert review KW - United States KW - Animals KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Safety KW - Practice Guidelines as Topic KW - Female KW - Pregnancy KW - Fetus -- drug effects KW - Pregnancy Complications -- drug therapy KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558526278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Developing+a+systematic+approach+to+safer+medication+use+during+pregnancy%3A+summary+of+a+Centers+for+Disease+Control+and+Prevention--convened+meeting.&rft.au=Broussard%2C+Cheryl+S%3BFrey%2C+Meghan+T%3BHernandez-Diaz%2C+Sonia%3BGreene%2C+Michael+F%3BChambers%2C+Christina+D%3BSahin%2C+Leyla%3BCollins+Sharp%2C+Beth+A%3BHonein%2C+Margaret+A&rft.aulast=Broussard&rft.aufirst=Cheryl&rft.date=2014-09-01&rft.volume=211&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2014.05.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-22 N1 - Date created - 2014-08-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Teratology. 1994 Jun;49(6):446-7 [7747265] J Womens Health (Larchmt). 2005 Mar;14(2):104-9 [15775727] Clin Perinatol. 2005 Sep;32(3):523-59 [16085019] Best Pract Res Clin Gastroenterol. 2007;21(5):755-69 [17889806] MMWR Surveill Summ. 2007 Dec 14;56(10):1-35 [18075488] Clin Pharmacol Ther. 2008 Jan;83(1):181-3 [18073777] BMJ. 2008 Apr 26;336(7650):924-6 [18436948] Med Ref Serv Q. 2008 Spring;27(1):73-80 [18689204] Ann Intern Med. 2009 Jan 6;150(1):45-9 [19124820] Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):137-50 [19161158] Birth Defects Res A Clin Mol Teratol. 2009 Mar;85(3):193-201 [19086018] Curr Pain Headache Rep. 2009 Oct;13(5):392-8 [19728967] Ann Pharmacother. 2010 Mar;44(3):456-61 [20164469] Birth. 2010 Jun;37(2):106-15 [20557533] MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36 [21088663] MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110 [21160459] Obstet Gynecol. 2011 Apr;117(4):1019-27 [21422882] Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):175-82 [21766440] Vaccine. 2011 Nov 15;29(49):9171-6 [21839794] Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8 [21514558] Pediatrics. 2011 Sep;128(3):611-6 [21807694] Hum Reprod Update. 2012 Jul;18(4):360-73 [22431565] J Womens Health (Larchmt). 2012 Aug;21(8):830-6 [22691031] Birth Defects Res A Clin Mol Teratol. 2012 Aug;94(8):670-6 [22786781] Pharmacoepidemiol Drug Saf. 2013 Sep;22(9):1013-8 [23893932] Fed Regist. 2014 Dec 4;79(233):72063-103 [25509060] Comment In: Am J Obstet Gynecol. 2015 Jul;213(1):116 [25557207] Am J Obstet Gynecol. 2015 Jul;213(1):115-6 [25555661] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ajog.2014.05.040 ER - TY - JOUR T1 - Attrition of MSM with HIV/AIDS along the continuum of care from screening to CD4 testing in China AN - 1548778387; 4583148 AB - The aim of this study is to describe attrition of newly diagnosed men who have sex with men (MSM) living with HIV/AIDS from screening to CD4 testing and provide suggestions to improve HIV case management in China. Data from 15 China-Gates Program project cities were collected on number of MSM who underwent each step from HIV screening to CD4 testing. Descriptive statistics were calculated. A total of 76,628 HIV screening tests were performed among MSM, of which 4563 were HIV-positive. Most attrition occurred at confirmatory and CD4 testing. Within the same year, 21% (1065/4063) of MSM who screened HIV-positive did not receive confirmatory testing and 34% (1025/3024) of MSM newly diagnosed with HIV/AIDS did not receive CD4 testing. Marked differences were observed between project areas in attrition at these points of the care continuum. Marked differences were also observed across areas in the rate of CD4 counts <350 cells/mcl, ranging from 23% to 87%. In the current process for diagnosis and management of HIV infection in China, many MSM are lost to follow-up at HIV confirmation and CD4 testing. Actions should be taken to reduce complexity and time lag from screening to CD4 test and emphasize the importance of remaining in care during posttest counseling. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Zhang, Dapeng AU - Li, Chengmei AU - Meng, Sining AU - Qi, Jinlei AU - Fu, Xiaojing AU - Sun, Jiangping AD - Chinese Center for Disease Control and Prevention Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1118 EP - 1121 VL - 26 IS - 9 SN - 0954-0121, 0954-0121 KW - Sociology KW - Sexual behaviour KW - Health care KW - AIDS KW - China KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548778387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Attrition+of+MSM+with+HIV%2FAIDS+along+the+continuum+of+care+from+screening+to+CD4+testing+in+China&rft.au=Zhang%2C+Dapeng%3BLi%2C+Chengmei%3BMeng%2C+Sining%3BQi%2C+Jinlei%3BFu%2C+Xiaojing%3BSun%2C+Jiangping&rft.aulast=Zhang&rft.aufirst=Dapeng&rft.date=2014-09-01&rft.volume=26&rft.issue=9&rft.spage=1118&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2014.902420 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-07-28 N1 - Last updated - 2014-07-29 N1 - SubjectsTermNotLitGenreText - 482 3617 6220; 11563 1025 1542 11325 6071; 10449 5772; 5775 13521; 93 116 30 DO - http://dx.doi.org/10.1080/09540121.2014.902420 ER - TY - JOUR T1 - Incidence and associated factors of pulmonary tuberculosis in HIV-infected children after highly active antiretroviral therapy (HAART) in China: a retrospective study AN - 1548775883; 4583137 AB - China is a country with high tuberculosis (TB) incidence but relatively low HIV prevalence. However, due to difficulties in diagnosis and reporting, true burden of HIV-associated TB in children is unknown. The objective of this study was to describe the incidence of pulmonary TB (PTB) after antiretroviral therapy (ART) and to study risk factors. A retrospective study was performed based on routinely collected data from China national pediatric free antiretroviral treatment database. A total of 3365 children under 15 years on ART from July 2005 to October 2012 were included. Multivariable logistic regression was used to detect associated factors. Two thousand nine hundred and ninety (89%) children got infected from HIV-positive mother, with median age of 6.7 (4.1, 10.0) years at highly active antiretroviral therapy (HAART) initiation in this program. Seventy-seven (2.3%) children were diagnosed with PTB after ART during 7.3 years cohort observation. Median time of occurrence was 212 (30-514) days. Overall incidence was 0.83 (0.65-1.01)/100 person-years (py), with the peak of 3.6/100 py in the first 3 months after antiretroviral treatment. WHO stage IV at baseline showed 2 (95% CI 1.0-6.8) times more risk for developing TB. Late clinical stage at ART initiation was shown to relate with TB incidence. PTB coinfection leads to higher mortality. Early diagnosis and treatment of HIV are highly required to reduce HIV-associated morbidity and mortality due to TB. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Mu, Weiwei AU - Zhao, Yan AU - Sun, Xin AU - Ma, Ye AU - Yu, Lan AU - Liu, Xia AU - Zhao, Decai AU - Dou, Zhihui AU - Fang, Hua AU - Zhang, Fujie AD - Chinese Center For Disease Control And Prevention Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1127 EP - 1135 VL - 26 IS - 9 SN - 0954-0121, 0954-0121 KW - Sociology KW - Risk KW - Mortality KW - Medical treatment KW - Tuberculosis KW - HIV KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548775883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Incidence+and+associated+factors+of+pulmonary+tuberculosis+in+HIV-infected+children+after+highly+active+antiretroviral+therapy+%28HAART%29+in+China%3A+a+retrospective+study&rft.au=Mu%2C+Weiwei%3BZhao%2C+Yan%3BSun%2C+Xin%3BMa%2C+Ye%3BYu%2C+Lan%3BLiu%2C+Xia%3BZhao%2C+Decai%3BDou%2C+Zhihui%3BFang%2C+Hua%3BZhang%2C+Fujie&rft.aulast=Mu&rft.aufirst=Weiwei&rft.date=2014-09-01&rft.volume=26&rft.issue=9&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2014.882492 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-07-28 N1 - Last updated - 2014-07-29 N1 - SubjectsTermNotLitGenreText - 13020 3617 6220; 8291 3409 6306; 5703 3617 6220; 7890 5792 10484; 11035; 93 116 30 DO - http://dx.doi.org/10.1080/09540121.2014.882492 ER - TY - JOUR T1 - Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats. AN - 1560095504; 25123171 AB - Welding fume is an exposure that consists of a mixture of metal-rich particulate matter with gases (ozone, carbon monoxide) and/or vapors (VOCs). Data suggests that welders are immune compromised. Given the inability of pulmonary leukocytes to properly respond to a secondary infection in animal models, the question arose whether the dysfunction persisted systemically. Our aim was to evaluate the circulating leukocyte population in terms of cellular activation, presence of oxidative stress, and functionality after a secondary challenge, following welding fume exposure. Rats were intratracheally instilled (ITI) with PBS or 2 mg of welding fume collected from a stainless steel weld. Rats were sacrificed 4 and 24 h post-exposure and whole blood was collected. Whole blood was used for cellular differential counts, RNA isolation with subsequent microarray and Ingenuity Pathway Analysis, and secondary stimulation with LPS utilizing TruCulture technology. In addition, mononuclear cells were isolated 24 h post-exposure to measure oxidative stress by flow cytometry and confocal microscopy. Welding fume exposure had rapid effects on the circulating leukocyte population as identified by relative mRNA expression changes. Instillation of welding fume reduced inflammatory protein production of circulating leukocytes when challenged with the secondary stimulus LPS. The effects were not related to transcription, but were observed in conjunction with oxidative stress. These findings support previous studies of an inadequate pulmonary immune response following a metal-rich exposure and extend those findings showing leukocyte dysfunction occurs systemically. JF - Particle and fibre toxicology AU - Erdely, Aaron AU - Antonini, James M AU - Young, Shih-Houng AU - Kashon, Michael L AU - Gu, Ja K AU - Hulderman, Tracy AU - Salmen, Rebecca AU - Meighan, Terence AU - Roberts, Jenny R AU - Zeidler-Erdely, Patti C AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 26505, WV, USA. efi4@cdc.gov. Y1 - 2014/08/15/ PY - 2014 DA - 2014 Aug 15 SP - 34 VL - 11 KW - Inflammation Mediators KW - 0 KW - Lipopolysaccharides KW - Particulate Matter KW - RNA, Messenger KW - Stainless Steel KW - 12597-68-1 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Lipopolysaccharides -- pharmacology KW - Transcription, Genetic KW - Gene Expression Profiling -- methods KW - Inflammation Mediators -- metabolism KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Cells, Cultured KW - Gene Expression Regulation KW - Immunocompromised Host KW - Time Factors KW - Male KW - Particulate Matter -- toxicity KW - Leukocytes -- metabolism KW - Leukocytes -- immunology KW - Stainless Steel -- toxicity KW - Oxidative Stress -- drug effects KW - Welding KW - Leukocytes -- drug effects KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560095504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ato