TY - CPAPER T1 - Electron Transfer Mechanisms: Evolving Theoretical Probes and Contact with Experiment T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39244651; 4358794 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Newton, Marshall D Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Probes KW - Electron transfer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39244651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Electron+Transfer+Mechanisms%3A+Evolving+Theoretical+Probes+and+Contact+with+Experiment&rft.au=Newton%2C+Marshall+D&rft.aulast=Newton&rft.aufirst=Marshall&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aqueous High Oxidation State Iron: Generation and Reactivity T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39240693; 4358154 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Cabelli, Diane E AU - Sharma, Virender K Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Oxidation KW - Iron KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Aqueous+High+Oxidation+State+Iron%3A+Generation+and+Reactivity&rft.au=Cabelli%2C+Diane+E%3BSharma%2C+Virender+K&rft.aulast=Cabelli&rft.aufirst=Diane&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiotracer Development for Imaging Studies in Addiction T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39237573; 4359795 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Fowler, Joanna S AU - Logan, Jean AU - Wang, Gene-Jack AU - Volkow, Nora D Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Addiction KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39237573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Radiotracer+Development+for+Imaging+Studies+in+Addiction&rft.au=Fowler%2C+Joanna+S%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BVolkow%2C+Nora+D&rft.aulast=Fowler&rft.aufirst=Joanna&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Energies Governing Electron Transfer: What we Know, what we Need to Learn T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39235664; 4358808 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Miller, John R Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Energy KW - Electron transfer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39235664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Energies+Governing+Electron+Transfer%3A+What+we+Know%2C+what+we+Need+to+Learn&rft.au=Miller%2C+John+R&rft.aulast=Miller&rft.aufirst=John&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Situ Time-Resolved Characterization of Novel Cu-MoO sub(2) Catalysts during the Water Gas Shift Reaction T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39225721; 4357611 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Wen, Wen AU - Liu, Jing AU - White, Michael G AU - Hanson, Jonathan C AU - Rodriguez, Jose A Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Catalysts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39225721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=In+Situ+Time-Resolved+Characterization+of+Novel+Cu-MoO+sub%282%29+Catalysts+during+the+Water+Gas+Shift+Reaction&rft.au=Wen%2C+Wen%3BLiu%2C+Jing%3BWhite%2C+Michael+G%3BHanson%2C+Jonathan+C%3BRodriguez%2C+Jose+A&rft.aulast=Wen&rft.aufirst=Wen&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Chemistry of Criticality-Safe Borated Ionic Liquids T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39219814; 4362694 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Szreder, Tomasz AU - Funston, Alison M AU - Wishart, James F AU - Reed, Christopher A AU - Kim, Kee-Chan Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Radiation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39219814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Radiation+Chemistry+of+Criticality-Safe+Borated+Ionic+Liquids&rft.au=Szreder%2C+Tomasz%3BFunston%2C+Alison+M%3BWishart%2C+James+F%3BReed%2C+Christopher+A%3BKim%2C+Kee-Chan&rft.aulast=Szreder&rft.aufirst=Tomasz&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improving Cold Flow Properties of Biodiesel T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39210366; 4358977 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Krishna, C R AU - Butcher, Thomas AU - Mahajan, Devinder Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Biomass KW - Fuels KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39210366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Improving+Cold+Flow+Properties+of+Biodiesel&rft.au=Krishna%2C+C+R%3BButcher%2C+Thomas%3BMahajan%2C+Devinder&rft.aulast=Krishna&rft.aufirst=C&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Proton-HZE-particle sequential dual-beam exposures increase anchorage-independent growth frequencies in primary human fibroblasts. AN - 68838187; 16953667 AB - The radiation field in deep space contains high levels of high-energy protons and substantially lower levels of high-atomic-number, high-energy (HZE) particles. Calculations indicate that cellular nuclei of human space travelers will be hit during a 3-year Mars mission by approximately 400 protons and approximately 0.4 HZE particles. Thus most cells in astronauts will be hit by a proton(s) before being hit by an HZE particle. To investigate effects of dual ion irradiations on human cells, we irradiated primary human neonatal fibroblasts with protons (1 GeV/nucleon, 20 cGy) followed from 2.5 min to 48 h later by iron or titanium ions (1 GeV/nucleon, 20 cGy) and then measured clonogenic survival and frequency of anchorage-independent growth. This frequency depends on the interval between hydrogen- and iron-ion irradiation, with a critical window between 2.5 min and 1 h producing about three times more anchorage-independent colonies per survivor than expected from simple addition of the two ions separately. The hydrogen-titanium-ion dual-beam irradiation produced similar increases that persisted to approximately 6 h. At longer intervals, anchorage-independent growth frequencies were similar to those expected for additivity. However, irradiation of cells with either an iron or a titanium particle first followed by protons produced only additive levels. JF - Radiation research AU - Zhou, Guangming AU - Bennett, Paula V AU - Cutter, Noelle C AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 488 EP - 494 VL - 166 IS - 3 SN - 0033-7587, 0033-7587 KW - Protons KW - 0 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Cell Proliferation -- radiation effects KW - Cells, Cultured KW - Humans KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Cell Adhesion -- radiation effects KW - Heavy Ions KW - Cosmic Radiation KW - Environmental Exposure KW - Fibroblasts -- radiation effects KW - Fibroblasts -- cytology KW - Fibroblasts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68838187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Proton-HZE-particle+sequential+dual-beam+exposures+increase+anchorage-independent+growth+frequencies+in+primary+human+fibroblasts.&rft.au=Zhou%2C+Guangming%3BBennett%2C+Paula+V%3BCutter%2C+Noelle+C%3BSutherland%2C+Betsy+M&rft.aulast=Zhou&rft.aufirst=Guangming&rft.date=2006-09-01&rft.volume=166&rft.issue=3&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Late effects of radiation on the central nervous system: role of vascular endothelial damage and glial stem cell survival. AN - 68834700; 16953668 AB - Selective irradiation of the vasculature of the rat spinal cord was used in this study, which was designed specifically to address the question as to whether it is the endothelial cell or the glial progenitor cell that is the target responsible for late white matter necrosis in the CNS. Selective irradiation of the vascular endothelium was achieved by the intraperitoneal (ip) administration of a boron compound known as BSH (Na(2)B(12)H(11)SH), followed by local irradiation with thermal neutrons. The blood-brain barrier is known to exclude BSH from the CNS parenchyma. Thirty minutes after the ip injection of BSH, the boron concentration in blood was 100 microg (10)B/ g, while that in the CNS parenchyma was below the detection limit of the boron analysis system, <1 microg (10)B/g. An ex vivo clonogenic assay of the O2A (oligodendrocyte-type 2 astrocyte) glial progenitor cell survival was performed 1 week after irradiation and at various times during the latent period before white matter necrosis in the spinal cord resulted in myelopathy. One week after 4.5 Gy of thermal neutron irradiation alone (approximately one-third of the dose required to produce a 50% incidence of radiation myelopathy), the average glial progenitor cell surviving fraction was 0.03. The surviving fraction of glial progenitor cells after a thermal neutron irradiation with BSH for a comparable effect was 0.46. The high level of glial progenitor cell survival after irradiation in the presence of BSH clearly reflects the lower dose delivered to the parenchyma due to the complete exclusion of BSH by the blood-brain barrier. The intermediate response of glial progenitor cells after irradiation with thermal neutrons in the presence of a boron compound known as BPA (p-dihydroxyboryl-phenylalanine), again for a dose that represents one-third the ED(50) for radiation-induced myelopathy, reflects the differential partition of boron-10 between blood and CNS parenchyma for this compound, which crosses the blood-brain barrier, at the time of irradiation. The large differences in glial progenitor survival seen 1 week after irradiation were also maintained during the 4-5-month latent period before the development of radiation myelopathy, due to selective white matter necrosis, after irradiation with doses that would produce a high incidence of radiation myelopathy. Glial progenitor survival was similar to control values at 100 days after irradiation with a dose of thermal neutrons in the presence of BSH, significantly greater than the ED(100), shortly before the normal time of onset of myelopathy. In contrast, glial progenitor survival was less than 1% of control levels after irradiation with 15 Gy of thermal neutrons alone. This dose of thermal neutrons represents the approximate ED(90-100) for myelopathy. The response to irradiation with an equivalent dose of X rays (ED(90): 23 Gy) was intermediate between these extremes as it was to thermal neutrons in the presence of BPA at a slightly lower dose equivalent to the approximate ED(60) for radiation myelopathy. The conclusions from these studies, performed at dose levels approximately iso-effective for radiation-induced myelopathy as a consequence of white matter necrosis, were that the large differences observed in glial progenitor survival were directly related to the dose distribution in the parenchyma. These observations clearly indicate the relative importance of the dose to the vascular endothelium as the primary event leading to white matter necrosis. JF - Radiation research AU - Coderre, Jeffrey A AU - Morris, Gerard M AU - Micca, Peggy L AU - Hopewell, John W AU - Verhagen, Ilja AU - Kleiboer, Bert J AU - van der Kogel, Albert J AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 495 EP - 503 VL - 166 IS - 3 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Rats KW - Radiation Dosage KW - Animals KW - Rats, Inbred F344 KW - Cells, Cultured KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Male KW - Endothelium, Vascular -- radiation effects KW - Spinal Cord -- radiation effects KW - Neuroglia -- radiation effects KW - Neuroglia -- pathology KW - Endothelium, Vascular -- pathology KW - Spinal Cord Diseases -- pathology KW - Spinal Cord Diseases -- etiology KW - Radiation Injuries -- pathology KW - Spinal Cord -- blood supply KW - Radiation Injuries -- etiology KW - Endothelium, Vascular -- injuries UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68834700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Late+effects+of+radiation+on+the+central+nervous+system%3A+role+of+vascular+endothelial+damage+and+glial+stem+cell+survival.&rft.au=Coderre%2C+Jeffrey+A%3BMorris%2C+Gerard+M%3BMicca%2C+Peggy+L%3BHopewell%2C+John+W%3BVerhagen%2C+Ilja%3BKleiboer%2C+Bert+J%3Bvan+der+Kogel%2C+Albert+J&rft.aulast=Coderre&rft.aufirst=Jeffrey&rft.date=2006-09-01&rft.volume=166&rft.issue=3&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-12 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Tropical dendrochemistry; a novel approach to estimate age and growth from ringless trees AN - 51461693; 2007-038702 JF - Geophysical Research Letters AU - Poussart, P M AU - Myneni, S C B AU - Lanzirotti, A Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5 EP - 5, L17711 PB - American Geophysical Union, Washington, DC VL - 33 IS - 17 SN - 0094-8276, 0094-8276 KW - tropical environment KW - calcium KW - Far East KW - oxygen KW - ion probe data KW - isotopes KW - Thailand KW - archives KW - mass spectra KW - paleoclimatology KW - Holocene KW - stable isotopes KW - Cenozoic KW - radioactive isotopes KW - geochronology KW - dates KW - carbon KW - absolute age KW - spectra KW - Asia KW - forests KW - alkaline earth metals KW - ringless trees KW - Quaternary KW - isotope ratios KW - global KW - C-13/C-12 KW - Miliusa velutina KW - O-18/O-16 KW - X-ray spectra KW - geochemical cycle KW - tree rings KW - metals KW - trees KW - seasonal variations KW - carbon cycle KW - C-14 KW - 03:Geochronology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51461693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Tropical+dendrochemistry%3B+a+novel+approach+to+estimate+age+and+growth+from+ringless+trees&rft.au=Poussart%2C+P+M%3BMyneni%2C+S+C+B%3BLanzirotti%2C+A&rft.aulast=Poussart&rft.aufirst=P&rft.date=2006-09-01&rft.volume=33&rft.issue=17&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F2006GL026929 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - absolute age; alkaline earth metals; archives; Asia; C-13/C-12; C-14; calcium; carbon; carbon cycle; Cenozoic; dates; Far East; forests; geochemical cycle; geochronology; global; Holocene; ion probe data; isotope ratios; isotopes; mass spectra; metals; Miliusa velutina; O-18/O-16; oxygen; paleoclimatology; Quaternary; radioactive isotopes; ringless trees; seasonal variations; spectra; stable isotopes; Thailand; tree rings; trees; tropical environment; X-ray spectra DO - http://dx.doi.org/10.1029/2006GL026929 ER - TY - JOUR T1 - Zinc coordination to multiple ligand atoms in organic-rich surface soils AN - 51367655; 2007-110260 JF - Environmental Science & Technology, ES & T AU - Martinez, Carmen Enid AU - Bazilevskaya, Katya A AU - Lanzirotti, Antonio Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 5688 EP - 5695 PB - American Chemical Society, Washington, DC VL - 40 IS - 18 SN - 0013-936X, 0013-936X KW - soils KW - zinc KW - toxic materials KW - sorption KW - X-ray diffraction data KW - pollutants KW - pollution KW - bioavailability KW - X-ray spectra KW - XANES spectra KW - spatial distribution KW - organic compounds KW - ligands KW - chemical reactions KW - wetlands KW - soil pollution KW - metals KW - X-ray fluorescence spectra KW - spectra KW - heterogeneity KW - chemical composition KW - geochemistry KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51367655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Zinc+coordination+to+multiple+ligand+atoms+in+organic-rich+surface+soils&rft.au=Martinez%2C+Carmen+Enid%3BBazilevskaya%2C+Katya+A%3BLanzirotti%2C+Antonio&rft.aulast=Martinez&rft.aufirst=Carmen&rft.date=2006-09-01&rft.volume=40&rft.issue=18&rft.spage=5688&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes0608343 L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 34 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - bioavailability; chemical composition; chemical fractionation; chemical reactions; geochemistry; heterogeneity; ligands; metals; organic compounds; pollutants; pollution; soil pollution; soils; sorption; spatial distribution; spectra; toxic materials; wetlands; X-ray diffraction data; X-ray fluorescence spectra; X-ray spectra; XANES spectra; zinc DO - http://dx.doi.org/10.1021/es0608343 ER - TY - JOUR T1 - Synchrotron mu -XRF mapping of elemental distributions across coral skeleton micro-architecture AN - 50988426; 2008-092522 JF - Geochimica et Cosmochimica Acta AU - Hendy, E AU - Lanzirotti, A AU - Rasbury, T AU - Lough, J AU - Anonymous Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1 PB - Elsevier, New York, NY VL - 70 IS - 18S SN - 0016-7037, 0016-7037 KW - calcium KW - Southwest Pacific KW - halogens KW - Sr/Ca KW - West Pacific KW - XANES spectra KW - synchrotron radiation KW - modern KW - partitioning KW - laboratory studies KW - Zoantharia KW - Coral Sea KW - Anthozoa KW - X-ray fluorescence spectra KW - Invertebrata KW - ecology KW - spectra KW - trace elements KW - geochemistry KW - Porites KW - alkaline earth metals KW - experimental studies KW - reef environment KW - aragonite KW - living taxa KW - biochemistry KW - Great Barrier Reef KW - South Pacific KW - Coelenterata KW - bromine KW - X-ray spectra KW - Scleractinia KW - metals KW - Pandora Reef KW - Pacific Ocean KW - Cnidaria KW - carbonates KW - strontium KW - growth KW - 10:Invertebrate paleontology KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50988426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Synchrotron+mu+-XRF+mapping+of+elemental+distributions+across+coral+skeleton+micro-architecture&rft.au=Hendy%2C+E%3BLanzirotti%2C+A%3BRasbury%2C+T%3BLough%2C+J%3BAnonymous&rft.aulast=Hendy&rft.aufirst=E&rft.date=2006-09-01&rft.volume=70&rft.issue=18S&rft.spage=A246&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2006.06.1591 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 16th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - alkaline earth metals; Anthozoa; aragonite; biochemistry; bromine; calcium; carbonates; Cnidaria; Coelenterata; Coral Sea; ecology; experimental studies; geochemistry; Great Barrier Reef; growth; halogens; Invertebrata; laboratory studies; living taxa; metals; modern; Pacific Ocean; Pandora Reef; partitioning; Porites; reef environment; Scleractinia; South Pacific; Southwest Pacific; spectra; Sr/Ca; strontium; synchrotron radiation; trace elements; West Pacific; X-ray fluorescence spectra; X-ray spectra; XANES spectra; Zoantharia DO - http://dx.doi.org/10.1016/j.gca.2006.06.1591 ER - TY - JOUR T1 - The next generation of synchrotron fluorescence imaging for geological applications AN - 50859473; 2008-099030 JF - Geochimica et Cosmochimica Acta AU - Ryan, Chris G AU - Siddons, D P AU - Moorhead, G AU - Dunn, P AU - Kirkham, R AU - Dragone, A AU - De Geronimo, G AU - Hough, Robert M AU - Etschmann, B E AU - Anonymous Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1 PB - Elsevier, New York, NY VL - 70 IS - 18S SN - 0016-7037, 0016-7037 KW - X-ray fluorescence KW - data processing KW - techniques KW - HYMOD KW - synchrotron radiation KW - GeoPIXE KW - computer programs KW - computers KW - X-ray analysis KW - synchrotrons KW - applications KW - algorithms KW - geochemistry KW - instruments KW - image analysis KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50859473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=The+next+generation+of+synchrotron+fluorescence+imaging+for+geological+applications&rft.au=Ryan%2C+Chris+G%3BSiddons%2C+D+P%3BMoorhead%2C+G%3BDunn%2C+P%3BKirkham%2C+R%3BDragone%2C+A%3BDe+Geronimo%2C+G%3BHough%2C+Robert+M%3BEtschmann%2C+B+E%3BAnonymous&rft.aulast=Ryan&rft.aufirst=Chris&rft.date=2006-09-01&rft.volume=70&rft.issue=18S&rft.spage=A550&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2006.06.1016 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 16th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 4 N1 - PubXState - NY N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - algorithms; applications; computer programs; computers; data processing; geochemistry; GeoPIXE; HYMOD; image analysis; instruments; synchrotron radiation; synchrotrons; techniques; X-ray analysis; X-ray fluorescence DO - http://dx.doi.org/10.1016/j.gca.2006.06.1016 ER - TY - CPAPER T1 - Image-Guided Localization of Positron Emitting Nanoparticles using Small Animal PET: Applications for Toxicokinetics and Toxicology T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40193967; 4334003 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Schiffer, Wynne AU - Shea, Colleen AU - Panessa-Warren, Barbara AU - Gang, Oleg AU - Van der Lelie, Daniel AU - Maye, Matthew AU - Ferrieri, Richard AU - Fowler, Joanna Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Nanoparticles KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Image-Guided+Localization+of+Positron+Emitting+Nanoparticles+using+Small+Animal+PET%3A+Applications+for+Toxicokinetics+and+Toxicology&rft.au=Schiffer%2C+Wynne%3BShea%2C+Colleen%3BPanessa-Warren%2C+Barbara%3BGang%2C+Oleg%3BVan+der+Lelie%2C+Daniel%3BMaye%2C+Matthew%3BFerrieri%2C+Richard%3BFowler%2C+Joanna&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RuBisCO without the Calvin Cycle Improves the Carbon Efficiency of Developing Green Seeds T2 - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AN - 40193456; 4330298 JF - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AU - Schwender, Joerg AU - Goffman, Fernando AU - Ohlrogge, John AU - Shachar-Hill, Yair Y1 - 2006/08/05/ PY - 2006 DA - 2006 Aug 05 KW - Calvin cycle KW - Ribulose-bisphosphate carboxylase KW - Seeds KW - Carbon cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.atitle=RuBisCO+without+the+Calvin+Cycle+Improves+the+Carbon+Efficiency+of+Developing+Green+Seeds&rft.au=Schwender%2C+Joerg%3BGoffman%2C+Fernando%3BOhlrogge%2C+John%3BShachar-Hill%2C+Yair&rft.aulast=Schwender&rft.aufirst=Joerg&rft.date=2006-08-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.aspb.org/pb2006/public/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding the Linkages between Gene, Enzyme and Metabolite T2 - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AN - 40188943; 4330911 JF - 2006 Joint Annual Meeting of the American Society of Plant Biologists and the Canadian Society of Plant Physiologists (Plant Biology 2006) AU - Rogers, Alistair AU - Weston, David AU - Tschaplinski, Timothy J AU - Wullschleger, Stan D Y1 - 2006/08/05/ PY - 2006 DA - 2006 Aug 05 KW - Metabolites KW - Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40188943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.atitle=Understanding+the+Linkages+between+Gene%2C+Enzyme+and+Metabolite&rft.au=Rogers%2C+Alistair%3BWeston%2C+David%3BTschaplinski%2C+Timothy+J%3BWullschleger%2C+Stan+D&rft.aulast=Rogers&rft.aufirst=Alistair&rft.date=2006-08-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Joint+Annual+Meeting+of+the+American+Society+of+Plant+Biologists+and+the+Canadian+Society+of+Plant+Physiologists+%28Plant+Biology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.aspb.org/pb2006/public/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Total syntheses of three copper (II) tetracarboranylphenylporphyrins containing 40 or 80 boron atoms and their biological properties in EMT-6 tumor-bearing mice. AN - 68095652; 16651000 AB - Three carboranyltetraphenylporphyrins containing 40 or 80 boron atoms were synthesized and evaluated for their biodistribution and toxicity in EMT-6 tumor-bearing mice. Copper (II) meso-5,10,15,20-tetrakis[3-methoxy-4-(o-carboranylmethoxy)phenyl]porphyrin, 6, and copper (II) meso-5,10,15,20-tetrakis[3-hydroxy-4-(o-carboranylmethoxy)phenyl]porphyrin, 8, are B40 congeners with different lipophilicities, each less than their B80 congener, copper (II) meso-5,10,15,20-tetrakis[m-(3,5-di-o-carboranylmethoxybenzyloxy)phenyl]porphyrin, 18. Two days after the last of a series of i.p. injections in BALB/c mice bearing EMT-6 mammary tumors, a dose of 185 mg/kg 6 (54 mg/kg B) delivered over 3.5 times the concentration of boron to tumor (169 microg/g B) than did 118 mg/kg 8 (36 mg/kg B), which delivered 35 microg/g B, or 87 mg/kg 18 (30 mg/kg B), which delivered 46 microg/g B. The tumor-to-blood and tumor-to-brain boron concentration ratios at that time for all three porphyrins exceeded 80:1. Two days after the last injection, there resulted moderate thrombocytopenia that essentially disappeared two days later from 6 and 18, and mild leukocytosis from 6, 8, and 18, all of which were clinically inconsequential. Thus, 6 may rank among the most clinically promising carboranyl porphyrins ever made to deliver 10B to tumors for boron neutron-capture therapy (BNCT) that has also been tested for its toxicity in vivo. JF - Bioorganic & medicinal chemistry AU - Wu, Haitao AU - Micca, Peggy L AU - Makar, Michael S AU - Miura, Michiko AD - Medical Department, Building 490, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 5083 EP - 5092 VL - 14 IS - 15 SN - 0968-0896, 0968-0896 KW - Antineoplastic Agents KW - 0 KW - Boron Compounds KW - Metalloporphyrins KW - copper (II) meso-5,10,15,20-tetrakis(3-methoxy-4-(o-carboranylmethoxy)phenyl)porphyrin KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Molecular Structure KW - Drug Screening Assays, Antitumor KW - Animals KW - Stereoisomerism KW - Transplantation, Heterologous KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Metalloporphyrins -- toxicity KW - Antineoplastic Agents -- pharmacokinetics KW - Mammary Neoplasms, Experimental -- blood supply KW - Antineoplastic Agents -- toxicity KW - Mammary Neoplasms, Experimental -- drug therapy KW - Antineoplastic Agents -- chemical synthesis KW - Boron Compounds -- chemical synthesis KW - Mammary Neoplasms, Experimental -- metabolism KW - Metalloporphyrins -- chemical synthesis KW - Copper -- chemistry KW - Metalloporphyrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68095652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Total+syntheses+of+three+copper+%28II%29+tetracarboranylphenylporphyrins+containing+40+or+80+boron+atoms+and+their+biological+properties+in+EMT-6+tumor-bearing+mice.&rft.au=Wu%2C+Haitao%3BMicca%2C+Peggy+L%3BMakar%2C+Michael+S%3BMiura%2C+Michiko&rft.aulast=Wu&rft.aufirst=Haitao&rft.date=2006-08-01&rft.volume=14&rft.issue=15&rft.spage=5083&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-22 N1 - Date created - 2006-06-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233. AN - 68076963; 16715483 AB - G-protein coupled receptors exist in both high and low agonist affinity conformations, with tracer levels of agonist radioligands preferentially binding to the former. The goal of the present study was to characterize the in vivo binding of the aminoalkyindole-based, CB1 receptor agonist, R-[125/131I]AM2233 ((2-[125/131I]iodo-phenyl)-[1-(1-methyl-piperidin-2-yl-methyl)-1H-indol-3-yl]-methanone), and to use this radiotracer to selectively measure the receptor occupancy by the related CB1 receptor agonist, WIN55212-2, to the agonist-preferring affinity state of the receptor. In mouse locomotor assays, both WIN55212-2 and AM2233 (racemic) produced an approximately 60% reduction in activity at 1 mg/kg, (i.v.) and completely inhibited activity at 3 mg/kg, confirming their agonist nature. In ex vivo autoradiography, preferential uptake of R-[131I]AM2233 was apparent in CB1 receptor-rich areas, including globus pallidus, substantia nigra, striatum, cerebellum, and hippocampus. Overall brain uptake of R-[131I]AM2233 was 1.3% injected activity/g at 5 min in mice. Coinjection of 3 mg/kg (i.v.) SR141716A, a CB1 receptor antagonist, with R-[125I]AM2233 inhibited the radiotracer binding almost to nonspecific levels in the striatum, globus pallidus, and substantia nigra, although residual binding to a non-CB1 receptor remained in the hippocampus. In contrast to the effect of SR141716A, coinjection of 10 mg/kg (i.v.) WIN55212-2, a high dose that produced an immediate and profound immobility and catalepsy in the mice, reduced CB1 receptor-specific binding of R-[125I]AM2233 in CB1 receptor-rich areas by only 21-43%. These observations suggest that the behavioral effects of CB1 receptor agonists are manifested with a relatively small fraction of the agonist-preferring affinity state of the receptor occupied. JF - Synapse (New York, N.Y.) AU - Dhawan, Jasbeer AU - Deng, Hongfeng AU - Gatley, S John AU - Makriyannis, Alexandros AU - Akinfeleye, Tolulope AU - Bruneus, Magalie AU - Dimaio, Alexis A AU - Gifford, Andrew N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 93 EP - 101 VL - 60 IS - 2 SN - 0887-4476, 0887-4476 KW - 2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone KW - 0 KW - Benzoxazines KW - Cannabinoids KW - Indoles KW - Iodine Radioisotopes KW - Morpholines KW - Naphthalenes KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Win 55212-2 KW - 5H31GI9502 KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Animals KW - Drug Interactions KW - Motor Activity -- physiology KW - Radioligand Assay KW - Piperidines -- metabolism KW - Rats KW - Indoles -- metabolism KW - Motor Activity -- drug effects KW - Morpholines -- metabolism KW - Male KW - Dose-Response Relationship, Drug KW - Binding, Competitive -- physiology KW - Morpholines -- pharmacology KW - Binding, Competitive -- drug effects KW - Mice KW - Protein Conformation -- drug effects KW - Binding Sites -- physiology KW - Piperidines -- pharmacology KW - Naphthalenes -- metabolism KW - Pyrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Binding Sites -- drug effects KW - Indoles -- pharmacology KW - Iodine Radioisotopes -- metabolism KW - Behavior, Animal -- drug effects KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Receptor, Cannabinoid, CB1 -- agonists KW - Neurons -- metabolism KW - Cannabinoids -- metabolism KW - Neurons -- drug effects KW - Brain -- drug effects KW - Brain -- anatomy & histology KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Behavior, Animal -- physiology KW - Brain -- metabolism KW - Cannabinoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68076963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Evaluation+of+the+in+vivo+receptor+occupancy+for+the+behavioral+effects+of+cannabinoids+using+a+radiolabeled+cannabinoid+receptor+agonist%2C+R-%5B125%2F131I%5DAM2233.&rft.au=Dhawan%2C+Jasbeer%3BDeng%2C+Hongfeng%3BGatley%2C+S+John%3BMakriyannis%2C+Alexandros%3BAkinfeleye%2C+Tolulope%3BBruneus%2C+Magalie%3BDimaio%2C+Alexis+A%3BGifford%2C+Andrew+N&rft.aulast=Dhawan&rft.aufirst=Jasbeer&rft.date=2006-08-01&rft.volume=60&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Mineralogy and petrology of comet Wild-2 nucleus samples; final results of the preliminary examination team AN - 50652194; 2008-086202 JF - Meteoritics & Planetary Science AU - Zolensky, Michael E AU - Bland, Phil AU - Bradley, John AU - Brearley, Adrian J AU - Brennan, Sean AU - Bridges, John AU - Brownlee, Donald E AU - Butterworth, Anna L AU - Dai, Zurong AU - Ebel, Denton S AU - Genge, Matt AU - Gounelle, Matthieu AU - Graham, Giles AU - Grossman, Jeff AU - Grossman, Lawrence AU - Harvey, Ralph AU - Ishii, Hope A AU - Kearsley, Anton T AU - Keller, Lindsay AU - Krot, Alexander AU - Langenhorst, Falko AU - Lanzirotti, Antonio AU - Leroux, Hugues AU - Matrajt, Graciela AU - Messenger, Keiko AU - Mikouchi, Takashi AU - Nakamura, Tomoki AU - Ohsumi, Kazumasa AU - Okudaira, Kyoko AU - Perronnet, Murielle AU - Rietmeijer, Frans AU - Simon, Steven AU - Stephan, Thomas AU - Stroud, Rhonda M AU - Taheri, Mitra AU - Tomeoka, Kazu AU - Toppani, Alice AU - Tsou, Peter AU - Tsuchiyama, Akira AU - Velbel, Michael AU - Weber, Iris AU - Weisberg, Mike AU - Westphal, Andrew J AU - Yano, Hajime AU - Zega, Thomas J AU - Anonymous Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1 PB - Meteoritical Society, Fayetteville, AR VL - 41, Supplement SN - 1086-9379, 1086-9379 KW - alteration KW - physical properties KW - mineral composition KW - comets KW - Stardust Mission KW - Wild Comet KW - petrography KW - cometary dust KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50652194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics+%26+Planetary+Science&rft.atitle=Mineralogy+and+petrology+of+comet+Wild-2+nucleus+samples%3B+final+results+of+the+preliminary+examination+team&rft.au=Zolensky%2C+Michael+E%3BBland%2C+Phil%3BBradley%2C+John%3BBrearley%2C+Adrian+J%3BBrennan%2C+Sean%3BBridges%2C+John%3BBrownlee%2C+Donald+E%3BButterworth%2C+Anna+L%3BDai%2C+Zurong%3BEbel%2C+Denton+S%3BGenge%2C+Matt%3BGounelle%2C+Matthieu%3BGraham%2C+Giles%3BGrossman%2C+Jeff%3BGrossman%2C+Lawrence%3BHarvey%2C+Ralph%3BIshii%2C+Hope+A%3BKearsley%2C+Anton+T%3BKeller%2C+Lindsay%3BKrot%2C+Alexander%3BLangenhorst%2C+Falko%3BLanzirotti%2C+Antonio%3BLeroux%2C+Hugues%3BMatrajt%2C+Graciela%3BMessenger%2C+Keiko%3BMikouchi%2C+Takashi%3BNakamura%2C+Tomoki%3BOhsumi%2C+Kazumasa%3BOkudaira%2C+Kyoko%3BPerronnet%2C+Murielle%3BRietmeijer%2C+Frans%3BSimon%2C+Steven%3BStephan%2C+Thomas%3BStroud%2C+Rhonda+M%3BTaheri%2C+Mitra%3BTomeoka%2C+Kazu%3BToppani%2C+Alice%3BTsou%2C+Peter%3BTsuchiyama%2C+Akira%3BVelbel%2C+Michael%3BWeber%2C+Iris%3BWeisberg%2C+Mike%3BWestphal%2C+Andrew+J%3BYano%2C+Hajime%3BZega%2C+Thomas+J%3BAnonymous&rft.aulast=Zolensky&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=41%2C+Supplement&rft.issue=&rft.spage=A167&rft.isbn=&rft.btitle=&rft.title=Meteoritics+%26+Planetary+Science&rft.issn=10869379&rft_id=info:doi/ L2 - http://cavern.uark.edu/~meteor/ LA - English DB - GeoRef N1 - Conference title - 69th annual meeting of the Meteoritical Society N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - AR N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - alteration; cometary dust; comets; mineral composition; petrography; physical properties; Stardust Mission; Wild Comet ER - TY - JOUR T1 - Binding and Transport of Metal Ions at the Dimer Interface of the Escherichia coli Metal Transporter YiiP AN - 19322365; 7061597 AB - YiiP is a representative member of the cation diffusion facilitator (CDF) family, a class of ubiquitous metal transporters that play an essential role in metal homeostasis. Recently, a pair of Zn super(2+)/Cd super(2+)-selective binding sites has been localized to two highly conserved aspartyl residues (Asp super(157)), each in a 2-fold-symmetry-related transmembrane segment 5 (TM5) of a YiiP homodimer. Here we report the functional and structural interactions between Asp super(157) and yet another highly conserved Asp super(49) in the TM2. Calorimetric binding analysis indicated that Asp super(49) and Asp super(157) contribute to a common Cd super(2+) binding site in each subunit. Copper phenanthroline oxidation of YiiP sub(D49C), YiiP sub(D157C), and YiiP sub(D49C/D157C) yielded inter- and intra-subunit cross-links among Cys super(49) and Cys super(157), consistent with the spatial proximity of two (Asp super(49)-Asp super(157)) sites at the dimer interface. Hg super(2+) binding to YiiP sub(D49C) or YiiP sub(D49C/D157C) also yielded a Cys super(49)-Hg super(2+)-Cys super(49) biscysteinate complex across the dimer interface, further establishing the interfacial location of a (Asp super(49)-Asp super(157)) sub(2) bimetal binding center. Two bound Cd super(2+) ions were found transported cooperatively with a sigmoidal dependence on the Cd super(2+) concentration (n = 1.4). The binding affinity, transport cooperativity, and rate were modestly reduced by either a D49C or D157C mutation, but greatly diminished when all the bidentate aspartate O-ligands in (Asp super(49)-Asp super(157)) sub(2) were replaced by the monodentate cysteine S-ligands. The functional significance of these findings is discussed based on the unique coordination chemistry of aspartyl residues and a model for the translocation pathway of metal ions at the YiiP dimer interface. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 23492 EP - 23502 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 33 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Ions KW - Metals KW - Copper KW - Homeostasis KW - Models KW - Cations KW - Cysteine KW - Structure-function relationships KW - Oxidation KW - Zinc KW - Escherichia coli KW - Diffusion KW - Translocation KW - Mutation KW - Cooperativity KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19322365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Binding+and+Transport+of+Metal+Ions+at+the+Dimer+Interface+of+the+Escherichia+coli+Metal+Transporter+YiiP&rft.au=Wei%2C+Yinan%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Yinan&rft.date=2006-08-01&rft.volume=281&rft.issue=33&rft.spage=23492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Ions; Homeostasis; Copper; Models; Cations; Structure-function relationships; Cysteine; Zinc; Oxidation; Diffusion; Mutation; Translocation; Cooperativity; Escherichia coli ER - TY - CPAPER T1 - On-farm Units to Produce Liquid and Easily Transportable Fuels T2 - 2006 Annual Conference of the Soil and Water Conservation Society (SWCS 2006) AN - 40232880; 4348575 JF - 2006 Annual Conference of the Soil and Water Conservation Society (SWCS 2006) AU - Mahajan, Devinder Y1 - 2006/07/22/ PY - 2006 DA - 2006 Jul 22 KW - Fuels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40232880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Soil+and+Water+Conservation+Society+%28SWCS+2006%29&rft.atitle=On-farm+Units+to+Produce+Liquid+and+Easily+Transportable+Fuels&rft.au=Mahajan%2C+Devinder&rft.aulast=Mahajan&rft.aufirst=Devinder&rft.date=2006-07-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Soil+and+Water+Conservation+Society+%28SWCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.swcs.org/documents/06_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characteristic Response Time of Global Mean Surface Temperature T2 - 2006 Second International Conference on Global Warming and the Next Ice Age AN - 40198482; 4335616 JF - 2006 Second International Conference on Global Warming and the Next Ice Age AU - Schwartz, Stephen E Y1 - 2006/07/17/ PY - 2006 DA - 2006 Jul 17 KW - Temperature effects KW - Response time UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40198482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Second+International+Conference+on+Global+Warming+and+the+Next+Ice+Age&rft.atitle=Characteristic+Response+Time+of+Global+Mean+Surface+Temperature&rft.au=Schwartz%2C+Stephen+E&rft.aulast=Schwartz&rft.aufirst=Stephen&rft.date=2006-07-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Second+International+Conference+on+Global+Warming+and+the+Next+Ice+Age&rft.issn=&rft_id=info:doi/ L2 - http://aerosols.lanl.gov/conf2006/LANLClimateConfAbstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plant Uptake and Release of Cesium-137: Application to Phytoremediation. T2 - 18th World Congress of Soil Science (WCSS 2006) AN - 40058458; 4248498 JF - 18th World Congress of Soil Science (WCSS 2006) AU - Fuhrmann, Mark Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Phytoremediation KW - Bioremediation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40058458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+World+Congress+of+Soil+Science+%28WCSS+2006%29&rft.atitle=Plant+Uptake+and+Release+of+Cesium-137%3A+Application+to+Phytoremediation.&rft.au=Fuhrmann%2C+Mark&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+World+Congress+of+Soil+Science+%28WCSS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://crops.confex.com/crops/wc2006/techprogram/AAG.HTM LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Crystal Structure of Escherichia coliL-Arabinose Isomerase (ECAI), The Putative Target of Biological Tagatose Production AN - 19456502; 6999971 AB - Escherichia coliL-arabinose isomerase (ECAI; EC 5.3.1.4) catalyzes the isomerization of L-arabinose to L-ribulose in vivo. This enzyme is also of commercial interest as it catalyzes the conversion of D-galactose to D-tagatose in vitro. The crystal structure of ECAI was solved and refined at 2.6 A resolution. The subunit structure of ECAI is organised into three domains: an N-terminal, a central and a C-terminal domain. It forms a crystallographic trimeric architecture in the asymmetric unit. Packing within the crystal suggests the idea that ECAI can form a hexameric assembly. Previous electron microscopic and biochemical studies supports that ECAI is hexameric in solution. A comparison with other known structures reveals that ECAI adopts a protein fold most similar to E. coli fucose isomerase (ECFI) despite very low sequence identity 9.7%. The structural similarity between ECAI and ECFI with regard to number of domains, overall fold, biological assembly, and active site architecture strongly suggests that the enzymes have functional similarities. Further, the crystal structure of ECAI forms a basis for indentifying molecular determinants responsible for isomerization of arabinose to ribulose in vivo and galactose to tagatose in vitro. JF - Journal of Molecular Biology AU - Manjasetty, BA AU - Chance, M R AD - Center for Synchrotron Biosciences, National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY 11973, USA, mark.chance@case.edu Y1 - 2006/07/07/ PY - 2006 DA - 2006 Jul 07 SP - 297 EP - 309 PB - Elsevier Ltd VL - 360 IS - 2 SN - 0022-2836, 0022-2836 KW - fucose isomerase KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Galactose KW - L-Arabinose KW - D-Galactose KW - L-Arabinose isomerase KW - Isomerization KW - D-tagatose KW - Subunit structure KW - Protein structure KW - Protein folding KW - Escherichia coli KW - Crystal structure KW - Active sites KW - Structure-activity relationships KW - L-ribulose KW - G 07320:Bacterial genetics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Crystal+Structure+of+Escherichia+coliL-Arabinose+Isomerase+%28ECAI%29%2C+The+Putative+Target+of+Biological+Tagatose+Production&rft.au=Manjasetty%2C+BA%3BChance%2C+M+R&rft.aulast=Manjasetty&rft.aufirst=BA&rft.date=2006-07-07&rft.volume=360&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.04.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Galactose; L-Arabinose; D-Galactose; L-Arabinose isomerase; Isomerization; D-tagatose; Protein structure; Subunit structure; Protein folding; Crystal structure; Active sites; L-ribulose; Structure-activity relationships; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2006.04.040 ER - TY - JOUR T1 - Crystal structure of trehalose-6-phosphate phosphatase-related protein: Biochemical and biological implications AN - 21345670; 6999062 AB - We report here the crystal structure of a trehalose-6-phosphate phosphatase-related protein (T6PP) from Thermoplasma acidophilum, TA1209, determined by the dual-wavelength anomalous diffraction (DAD) method. T6PP is a member of the haloacid dehalogenase (HAD) superfamily with significant sequence homology with trehalose-6-phosphate phosphatase, phosphoserine phosphatase, P-type ATPases and other members of the family. T6PP possesses a core domain of known a/b-hydrolase fold, characteristic of the HAD family, and a cap domain, with a tertiary fold consisting of a four-stranded b-sheet with two a-helices on one side of the sheet. An active-site magnesium ion and a glycerol molecule bound at the interface between the two domains provide insight into the mode of substrate binding by T6PP. A trehalose-6-phosphate molecule modeled into a cage formed by the two domains makes favorable interactions with the protein molecule. We have confirmed that T6PP is a trehalose phosphatase from amino acid sequence, three-dimensional structure, and biochemical assays. JF - Protein Science AU - Rao, Krishnamurthy N AU - Kumaran, Desigan AU - Seetharaman, Jayaraman AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. New York Structural Biology Center, New York, New York 10027, USA. SGX Pharmaceuticals, Inc., San Diego, California 92121, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1735 EP - 1744 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 15 IS - 7 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Adenosinetriphosphatase KW - Thermoplasma acidophilum KW - trehalose-6-phosphate phosphatase KW - Trehalose KW - trehalose-6-phosphate KW - Glycerol KW - Homology KW - Crystal structure KW - Diffraction KW - Magnesium KW - Phosphoserine phosphatase KW - Amino acid sequence KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structure+of+trehalose-6-phosphate+phosphatase-related+protein%3A+Biochemical+and+biological+implications&rft.au=Rao%2C+Krishnamurthy+N%3BKumaran%2C+Desigan%3BSeetharaman%2C+Jayaraman%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Rao&rft.aufirst=Krishnamurthy&rft.date=2006-07-01&rft.volume=15&rft.issue=7&rft.spage=1735&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Glycerol; Adenosinetriphosphatase; trehalose-6-phosphate; Homology; Crystal structure; Trehalose; trehalose-6-phosphate phosphatase; Diffraction; Magnesium; Phosphoserine phosphatase; Amino acid sequence; Thermoplasma acidophilum ER - TY - JOUR T1 - Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals. AN - 67975473; 16703400 AB - RATIONALEChildren and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism.OBJECTIVEUsing an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the adolescent rodent brain. Small animal PET (microPET), in combination with the glucose analog radiotracer, (18)FDG, were used to evaluate the metabolic consequences of inhaled toluene.METHODSThe exposure protocol paralleled our previously established method for assessing the conditioned reinforcing effects of toluene (5,000 ppm) using the conditioned place preference (CPP) paradigm. Animals were scanned at baseline and 2 h after the last exposure. Follow-up (18)FDG scans occurred 1 day, 3 weeks, and 2 months later.RESULTSAfter six pairings, 38% of the animals preferred the toluene paired chamber and 25% were averse. The immediate metabolic effect in toluene-exposed animals was a 20% decline in whole brain (18)FDG uptake. Twenty-four hours following the last exposure, the whole brain decline was 40%, and 2 months later, the decline was 30% of pretoluene levels. A region-by-region analysis demonstrated significant additional decreases in the pons, cerebellum, striatum, midbrain, temporal cortex, and hippocampus. Two months after toluene cessation, regions of complete metabolic recovery were the thalamus and cerebellum; however, the temporal cortex did not recover.CONCLUSIONSBrain uptake of (18)FDG appears to be a useful tool for examining the metabolic impact of toluene abuse, which include a profound decline followed by region-specific recovery after cessation. JF - Psychopharmacology AU - Schiffer, Wynne K AU - Lee, Dianne E AU - Alexoff, David L AU - Ferrieri, Rich AU - Brodie, Jonathan D AU - Dewey, Stephen L AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. wynne@bnl.gov Y1 - 2006/06// PY - 2006 DA - June 2006 SP - 159 EP - 167 VL - 186 IS - 2 SN - 0033-3158, 0033-3158 KW - Solvents KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Toluene KW - 3FPU23BG52 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Brain Mapping KW - Reinforcement (Psychology) KW - Tomography, Emission-Computed KW - Disease Models, Animal KW - Male KW - Solvents -- toxicity KW - Brain -- drug effects KW - Substance-Related Disorders -- etiology KW - Brain -- metabolism KW - Toluene -- toxicity KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology KW - Brain -- diagnostic imaging KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67975473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Metabolic+correlates+of+toluene+abuse%3A+decline+and+recovery+of+function+in+adolescent+animals.&rft.au=Schiffer%2C+Wynne+K%3BLee%2C+Dianne+E%3BAlexoff%2C+David+L%3BFerrieri%2C+Rich%3BBrodie%2C+Jonathan+D%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2006-06-01&rft.volume=186&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-20 N1 - Date created - 2006-05-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Expression of the E. coli fpg protein in CHO cells lowers endogenous oxypurine clustered damage levels and decreases accumulation of endogenous Hprt mutations AN - 19805077; 7422679 AB - Endogenous DNA damage clusters - two or more oxidized bases, abasic sites, or strand breaks within about 20 base pairs on opposing strands - can accumulate in unirradiated mammalian cells, and may be significant origins of spontaneous detrimental biological effects. Factors determining the levels of such endogenous clusters are largely unknown. To determine if cellular repair genotype can affect endogenous cluster levels in mammalian cells, the authors examined cluster levels, growth rates, and mutant frequencies in Chinese hamster ovary cells expressing the Escherichia coli glycosylase fpg protein, whose principal substrates are oxidized purines. In cells expressing high levels of fpg protein, the levels of oxypurine clustered damages were decreased while those of oxypyrimidine clusters and abasic clusters were unchanged. Furthermore, in these cells, the growth rates were increased and the level of spontaneous background mutants in the hypoxanthine guanine phosphoribosyl transferase gene was decreased. These results suggest that endogenous clusters are potentially detrimental DNA damages, and that their levels - as well as the detrimental consequences of their presence - can be effectively reduced by increased cellular activity of specific DNA repair proteins. Environ. Mol. Mutagen., 2006. Published 2006 Wiley-Liss, Inc. JF - Environmental and Molecular Mutagenesis AU - Paul, S AU - Gros, L AU - Laval, J AU - Sutherland, B M AD - Biology Department, Bldg. 463, 50 Bell Avenue, Brookhaven National Laboratory, Upton, NY 11973, USA, bms@bnl.gov Y1 - 2006/06// PY - 2006 DA - Jun 2006 SP - 311 EP - 319 VL - 47 IS - 5 SN - 0893-6692, 0893-6692 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Growth rate KW - Mutagens KW - Mutant frequency KW - DNA-formamidopyrimidine glycosylase KW - Genotypes KW - DNA repair KW - purines KW - Mutagenesis KW - DNA damage KW - Guanine KW - Mammalian cells KW - Escherichia coli KW - Hypoxanthine KW - Mutation KW - Fpg protein KW - Base pairs KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19805077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Expression+of+the+E.+coli+fpg+protein+in+CHO+cells+lowers+endogenous+oxypurine+clustered+damage+levels+and+decreases+accumulation+of+endogenous+Hprt+mutations&rft.au=Paul%2C+S%3BGros%2C+L%3BLaval%2C+J%3BSutherland%2C+B+M&rft.aulast=Paul&rft.aufirst=S&rft.date=2006-06-01&rft.volume=47&rft.issue=5&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20208 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Growth rate; Mutagens; DNA-formamidopyrimidine glycosylase; Mutant frequency; Genotypes; DNA repair; purines; Mutagenesis; DNA damage; Guanine; Mammalian cells; Hypoxanthine; Mutation; Fpg protein; Base pairs; Escherichia coli DO - http://dx.doi.org/10.1002/em.20208 ER - TY - CPAPER T1 - Magnetic Resonance Microscopy of a Mouse Model of Attention-Deficit-Hyperactivity Disorder: Role of D4 Dopamine Receptors T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40057221; 4245814 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Ma, Yu AU - Hof, Patrick R AU - Grant, Samuel Colles AU - Blackband, Stephen J AU - Lee, Hai-Dee AU - Marcelo, Rubinstein AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Microscopy KW - N.M.R. KW - Dopamine D4 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40057221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Magnetic+Resonance+Microscopy+of+a+Mouse+Model+of+Attention-Deficit-Hyperactivity+Disorder%3A+Role+of+D4+Dopamine+Receptors&rft.au=Ma%2C+Yu%3BHof%2C+Patrick+R%3BGrant%2C+Samuel+Colles%3BBlackband%2C+Stephen+J%3BLee%2C+Hai-Dee%3BMarcelo%2C+Rubinstein%3BBenveniste%2C+Helene&rft.aulast=Ma&rft.aufirst=Yu&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Slotted Surface Coil for Magnetic Resonance Imaging at 4T T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40047487; 4245718 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Solis, Sergio AU - Wang, Ruiliang AU - Tomasi, Dardo AU - Rodriguez, Alfredo Odon Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Magnetic resonance imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40047487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Slotted+Surface+Coil+for+Magnetic+Resonance+Imaging+at+4T&rft.au=Solis%2C+Sergio%3BWang%2C+Ruiliang%3BTomasi%2C+Dardo%3BRodriguez%2C+Alfredo+Odon&rft.aulast=Solis&rft.aufirst=Sergio&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 'More' may be 'Less': Deficient Dichotic Listening Performance in Autism is Associated with Hyperactivation of Bilateral Language Brain Regions T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40045773; 4243788 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Bentwich, Jonathan AU - Maletic-Savatich, Mirjiana AU - Caparelli, Elisabeth AU - Anshul, Airen AU - Foerster, Bernd AU - Cohen, Michael AU - Pradhan, Kith AU - Ma, Jim AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Brain KW - Language KW - Autism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40045773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=%27More%27+may+be+%27Less%27%3A+Deficient+Dichotic+Listening+Performance+in+Autism+is+Associated+with+Hyperactivation+of+Bilateral+Language+Brain+Regions&rft.au=Bentwich%2C+Jonathan%3BMaletic-Savatich%2C+Mirjiana%3BCaparelli%2C+Elisabeth%3BAnshul%2C+Airen%3BFoerster%2C+Bernd%3BCohen%2C+Michael%3BPradhan%2C+Kith%3BMa%2C+Jim%3BBenveniste%2C+Helene&rft.aulast=Bentwich&rft.aufirst=Jonathan&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Cocaine on the Rat Brain Apparent Diffusion Coefficient, Cerebral Blood Volume and Mean Arterial Blood Pressure T2 - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AN - 40019642; 4243774 JF - 14th Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006) AU - Du, Congwu AU - Ma, Yu AU - Forester, Bernd AU - Yu, Mei AU - Benveniste, Helene Y1 - 2006/05/06/ PY - 2006 DA - 2006 May 06 KW - Blood KW - Blood pressure KW - Diffusion coefficients KW - Brain KW - Cocaine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40019642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=The+Effect+of+Cocaine+on+the+Rat+Brain+Apparent+Diffusion+Coefficient%2C+Cerebral+Blood+Volume+and+Mean+Arterial+Blood+Pressure&rft.au=Du%2C+Congwu%3BMa%2C+Yu%3BForester%2C+Bernd%3BYu%2C+Mei%3BBenveniste%2C+Helene&rft.aulast=Du&rft.aufirst=Congwu&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ismrm.org/06/2006_program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. AN - 67932462; 16636269 AB - Gamma-secretase is an intramembrane-cleaving aspartyl protease required for the normal development of metazoans because it processes Notch within cellular membranes to release its signaling domain. More than two dozen additional substrates of diverse functions have been reported, including the Notch ligands Delta and Jagged, N- and E-cadherins, and a sodium channel subunit. The protease is causally implicated in Alzheimer's disease because it releases the neurotoxic amyloid beta-peptide (Abeta) from its precursor, APP. Gamma-secretase occurs as a large complex containing presenilin (bearing the active site aspartates), nicastrin, Aph-1, and Pen-2. Because the complex contains at least 18 transmembrane domains, crystallographic approaches to its structure are difficult and remote. We recently purified the human complex essentially to homogeneity from stably expressing mammalian cells. Here, we use EM and single-particle image analysis on the purified enzyme, which produces physiological ratios of Abeta40 and Abeta42, to obtain structural information on an intramembrane protease. The 3D EM structure revealed a large, cylindrical interior chamber of approximately 20-40 A in length, consistent with a proteinaceous proteolytic site that is occluded from the hydrophobic environment of the lipid bilayer. Lectin tagging of the nicastrin ectodomain enabled proper orientation of the globular, approximately 120-A-long complex within the membrane and revealed approximately 20-A pores at the top and bottom that provide potential exit ports for cleavage products to the extra- and intracellular compartments. Our reconstructed 3D map provides a physical basis for hydrolysis of transmembrane substrates within a lipid bilayer and release of the products into distinct subcellular compartments. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lazarov, Vlado K AU - Fraering, Patrick C AU - Ye, Wenjuan AU - Wolfe, Michael S AU - Selkoe, Dennis J AU - Li, Huilin AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2006/05/02/ PY - 2006 DA - 2006 May 02 SP - 6889 EP - 6894 VL - 103 IS - 18 SN - 0027-8424, 0027-8424 KW - Multiprotein Complexes KW - 0 KW - Concanavalin A KW - 11028-71-0 KW - Amyloid Precursor Protein Secretases KW - EC 3.4.- KW - Endopeptidases KW - Aspartic Acid Endopeptidases KW - EC 3.4.23.- KW - BACE1 protein, human KW - EC 3.4.23.46 KW - Index Medicus KW - Animals KW - Concanavalin A -- metabolism KW - Models, Molecular KW - Humans KW - Microscopy, Electron KW - Image Processing, Computer-Assisted KW - Endopeptidases -- isolation & purification KW - Endopeptidases -- ultrastructure KW - Endopeptidases -- metabolism KW - Protein Structure, Tertiary KW - Endopeptidases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67932462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Electron+microscopic+structure+of+purified%2C+active+gamma-secretase+reveals+an+aqueous+intramembrane+chamber+and+two+pores.&rft.au=Lazarov%2C+Vlado+K%3BFraering%2C+Patrick+C%3BYe%2C+Wenjuan%3BWolfe%2C+Michael+S%3BSelkoe%2C+Dennis+J%3BLi%2C+Huilin&rft.aulast=Lazarov&rft.aufirst=Vlado&rft.date=2006-05-02&rft.volume=103&rft.issue=18&rft.spage=6889&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-05 N1 - Date created - 2006-05-03 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Science. 1999 Dec 10;286(5447):2153-6 [10591646] J Struct Biol. 1999 Dec 1;128(1):82-97 [10600563] Annu Rev Biochem. 1999;68:1015-68 [10872471] Mol Cell. 2000 Sep;6(3):625-36 [11030342] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2720-5 [11867728] Nat Cell Biol. 2002 May;4(5):E110-1; author reply E111-2 [11988746] Biochemistry. 2003 Jan 14;42(1):137-44 [12515548] Nature. 2003 Mar 27;422(6930):438-41 [12660785] Science. 2003 May 9;300(5621):980-4 [12738865] J Biol Chem. 2003 Sep 26;278(39):37213-22 [12857757] Science. 2003 Oct 31;302(5646):814-8 [14593165] Nature. 2004 Jan 1;427(6969):36-44 [14661030] Biochemistry. 2004 Jan 20;43(2):323-33 [14717586] Nat Rev Mol Cell Biol. 2004 Mar;5(3):177-87 [14990998] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Biochemistry. 2004 Aug 3;43(30):9774-89 [15274632] Nature. 2004 Aug 12;430(7001):806-10 [15306816] J Microsc. 1987 May;146(Pt 2):113-36 [3302267] Biochemistry. 1995 Aug 15;34(32):10272-8 [7640283] Nat Med. 1996 Aug;2(8):864-70 [8705854] J Struct Biol. 1996 Jan-Feb;116(1):190-9 [8742743] Cell. 1998 Feb 6;92(3):367-80 [9476896] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7109-14 [9618547] Biochemistry. 1998 Nov 24;37(47):16465-71 [9843412] Curr Opin Struct Biol. 1999 Oct;9(5):572-7 [10508764] Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5 [15563588] J Biol Chem. 2005 Feb 11;280(6):4383-92 [15569674] Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3230-5 [15722417] J Mol Biol. 2005 Jun 10;349(3):659-69 [15890365] Nat Struct Mol Biol. 2005 Jun;12(6):552-3 [15880121] FEBS J. 2005 Jun;272(11):2727-33 [15943807] Cell. 2005 Aug 12;122(3):435-47 [16096062] J Biol Chem. 2005 Oct 21;280(42):35352-60 [16046406] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Enzymatic activity of the SARS coronavirus main proteinase dimer AN - 19784156; 7494476 AB - The enzymatic activity of the SARS coronavirus main proteinase dimer was characterized by a sensitive, quantitative assay. The new, fluorogenic substrate, (Ala-Arg-Leu-Gln-NH)2-Rhodamine, contained a severe acute respiratory syndrome coronavirus (SARS CoV) main proteinase consensus cleavage sequence and Rhodamine 110, one of the most detectable compounds known, as the reporter group. The gene for the enzyme was cloned in the absence of purification tags, expressed in Escherichia coli and the enzyme purified. Enzyme activity from the SARS CoV main proteinase dimer could readily be detected at low pM concentrations. The enzyme exhibited a high Km, and is unusually sensitive to ionic strength and reducing agents. JF - FEBS Letters AU - Graziano, Vito AU - McGrath, William J AU - Degruccio, Ann Marie AU - Dunn, John J AU - Mangel, Walter F AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA, mangel@bnl.gov Y1 - 2006/05// PY - 2006 DA - May 2006 SP - 2577 EP - 2583 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 580 IS - 11 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Antiviral agents KW - Fluorogenic substrate KW - High throughput screening KW - Proteinase KW - Rhodamine KW - SARS KW - Ionic strength KW - Severe acute respiratory syndrome KW - Reducing agents KW - Escherichia coli KW - Conserved sequence KW - Enzymatic activity KW - rhodamine KW - SARS coronavirus KW - J 02320:Cell Biology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19784156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Enzymatic+activity+of+the+SARS+coronavirus+main+proteinase+dimer&rft.au=Graziano%2C+Vito%3BMcGrath%2C+William+J%3BDegruccio%2C+Ann+Marie%3BDunn%2C+John+J%3BMangel%2C+Walter+F&rft.aulast=Graziano&rft.aufirst=Vito&rft.date=2006-05-01&rft.volume=580&rft.issue=11&rft.spage=2577&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ionic strength; Reducing agents; Severe acute respiratory syndrome; Conserved sequence; Proteinase; Enzymatic activity; rhodamine; Escherichia coli; SARS coronavirus DO - http://dx.doi.org/10.1016/j.febslet.2006.04.004 ER - TY - CPAPER T1 - Variability of Deep Convective Cloud Characteristics Across the Tropical Pacific T2 - 27th Conference on Hurricanes and Tropical Meteorology AN - 39885604; 4167972 JF - 27th Conference on Hurricanes and Tropical Meteorology AU - Jensen, Michael P Y1 - 2006/04/24/ PY - 2006 DA - 2006 Apr 24 KW - Tropical Pacific KW - Clouds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.atitle=Variability+of+Deep+Convective+Cloud+Characteristics+Across+the+Tropical+Pacific&rft.au=Jensen%2C+Michael+P&rft.aulast=Jensen&rft.aufirst=Michael&rft.date=2006-04-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.issn=&rft_id=info:doi/ L2 - http://ams.confex.com/ams/27Hurricanes/techprogram/program_339.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Knock-out of SO1377 gene, which encodes the member of a conserved hypothetical bacterial protein family COG2268, results in alteration of iron metabolism, increased spontaneous mutation and hydrogen peroxide sensitivity in Shewanella oneidensis MR-1. AN - 68006947; 16600046 AB - BACKGROUNDShewanella oneidensis MR-1 is a facultative, gram-negative bacterium capable of coupling the oxidation of organic carbon to a wide range of electron acceptors such as oxygen, nitrate and metals, and has potential for bioremediation of heavy metal contaminated sites. The complete 5-Mb genome of S. oneidensis MR-1 was sequenced and standard sequence-comparison methods revealed approximately 42% of the MR-1 genome encodes proteins of unknown function. Defining the functions of hypothetical proteins is a great challenge and may need a systems approach. In this study, by using integrated approaches including whole genomic microarray and proteomics, we examined knockout effects of the gene encoding SO1377 (gi24372955), a member of the conserved, hypothetical, bacterial protein family COG2268 (Clusters of Orthologous Group) in bacterium Shewanella oneidensis MR-1, under various physiological conditions.RESULTSCompared with the wild-type strain, growth assays showed that the deletion mutant had a decreased growth rate when cultured aerobically, but not affected under anaerobic conditions. Whole-genome expression (RNA and protein) profiles revealed numerous gene and protein expression changes relative to the wild-type control, including some involved in iron metabolism, oxidative damage protection and respiratory electron transfer, e. g. complex IV of the respiration chain. Although total intracellular iron levels remained unchanged, whole-cell electron paramagnetic resonance (EPR) demonstrated that the level of free iron in mutant cells was 3 times less than that of the wild-type strain. Siderophore excretion in the mutant also decreased in iron-depleted medium. The mutant was more sensitive to hydrogen peroxide and gave rise to 100 times more colonies resistant to gentamicin or kanamycin.CONCLUSIONOur results showed that the knock-out of SO1377 gene had pleiotropic effects and suggested that SO1377 may play a role in iron homeostasis and oxidative damage protection in S. oneidensis MR-1. JF - BMC genomics AU - Gao, Weimin AU - Liu, Yongqing AU - Giometti, Carol S AU - Tollaksen, Sandra L AU - Khare, Tripti AU - Wu, Liyou AU - Klingeman, Dawn M AU - Fields, Matthew W AU - Zhou, Jizhong AD - Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. wgao@bnl.gov Y1 - 2006/04/06/ PY - 2006 DA - 2006 Apr 06 SP - 76 VL - 7 KW - Bacterial Proteins KW - 0 KW - Siderophores KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Phenotype KW - Gene Expression Regulation, Bacterial KW - Cells, Cultured KW - Models, Genetic KW - Electron Spin Resonance Spectroscopy KW - Proteomics KW - Transcription, Genetic KW - Siderophores -- biosynthesis KW - Cell Survival KW - Shewanella -- drug effects KW - Conserved Sequence -- genetics KW - Bacterial Proteins -- genetics KW - Hydrogen Peroxide -- pharmacology KW - Genes, Bacterial -- genetics KW - Shewanella -- growth & development KW - Mutagenesis -- genetics KW - Bacterial Proteins -- classification KW - Shewanella -- cytology KW - Iron -- metabolism KW - Shewanella -- genetics KW - Gene Deletion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68006947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Knock-out+of+SO1377+gene%2C+which+encodes+the+member+of+a+conserved+hypothetical+bacterial+protein+family+COG2268%2C+results+in+alteration+of+iron+metabolism%2C+increased+spontaneous+mutation+and+hydrogen+peroxide+sensitivity+in+Shewanella+oneidensis+MR-1.&rft.au=Gao%2C+Weimin%3BLiu%2C+Yongqing%3BGiometti%2C+Carol+S%3BTollaksen%2C+Sandra+L%3BKhare%2C+Tripti%3BWu%2C+Liyou%3BKlingeman%2C+Dawn+M%3BFields%2C+Matthew+W%3BZhou%2C+Jizhong&rft.aulast=Gao&rft.aufirst=Weimin&rft.date=2006-04-06&rft.volume=7&rft.issue=&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-05-25 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Gene. 1995 Jul 4;160(1):63-7 [7628718] J Bacteriol. 1995 May;177(9):2305-14 [7730258] Exp Gerontol. 1995 Mar-Apr;30(2):99-124 [8591812] Anal Chem. 1996 Mar 1;68(5):850-8 [8779443] Mol Cell Biol. 1996 Nov;16(11):6303-12 [8887660] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13635-40 [8942986] EMBO J. 1996 Nov 15;15(22):6122-31 [8947034] Gene. 1997 Mar 25;188(1):69-75 [9099861] Int J Biochem Cell Biol. 1997 Feb;29(2):271-4 [9147127] J Biol Chem. 1997 May 23;272(21):13793-802 [9153235] J Bacteriol. 1997 Oct;179(20):6228-37 [9335267] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15189-93 [9860944] Curr Opin Microbiol. 1999 Apr;2(2):188-94 [10322176] FEBS Lett. 1999 Jul 30;456(1):13-6 [10452520] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2099-104 [15684069] EMBO J. 2000 Jun 1;19(11):2444-51 [10835343] Ann N Y Acad Sci. 1999;893:13-8 [10672226] J Bacteriol. 2005 Apr;187(7):2501-7 [15774893] FEMS Microbiol Rev. 2001 Aug;25(4):405-24 [11524131] Respir Physiol. 2001 Nov 15;128(3):393-401 [11718766] Appl Environ Microbiol. 2002 Feb;68(2):881-92 [11823232] J Bacteriol. 2002 Aug;184(16):4612-6 [12142431] Biotechnol Bioeng. 2002 Dec 20;80(6):637-49 [12378605] Nat Biotechnol. 2002 Nov;20(11):1118-23 [12368813] Nat Biotechnol. 2002 Nov;20(11):1093-4 [12410251] J Proteome Res. 2002 May-Jun;1(3):211-5 [12645897] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4191-6 [12651953] FEMS Microbiol Rev. 2003 Jun;27(2-3):239-61 [12829270] OMICS. 2003 Summer;7(2):177-91 [14506847] Proteomics. 2004 Jan;4(1):59-77 [14730672] J Biol Chem. 1975 May 25;250(10):4007-21 [236308] Anal Biochem. 1978 Apr;85(2):331-40 [646092] Anal Biochem. 1987 Jan;160(1):47-56 [2952030] Electrophoresis. 1991 Jul-Aug;12(7-8):536-43 [1717251] Infect Immun. 1991 Dec;59(12):4310-7 [1937792] Appl Environ Microbiol. 1994 Aug;60(8):2802-10 [8085824] FEBS Lett. 1995 Jan 30;358(3):273-7 [7843414] FEBS Lett. 1995 Oct 2;373(1):13-8 [7589424] N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Improved Representation of Cloud Droplet Activation and Autoconversion and their Implications for Estimating Aerosol Indirect Effects T2 - 2006 European Geosciences Union General Assembly (EGU 2006) AN - 39891686; 4172732 JF - 2006 European Geosciences Union General Assembly (EGU 2006) AU - Liu, Y AU - Daum, P AU - Mcgraw, R AU - Miller, M Y1 - 2006/04/02/ PY - 2006 DA - 2006 Apr 02 KW - Aerosols KW - Clouds UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.atitle=Improved+Representation+of+Cloud+Droplet+Activation+and+Autoconversion+and+their+Implications+for+Estimating+Aerosol+Indirect+Effects&rft.au=Liu%2C+Y%3BDaum%2C+P%3BMcgraw%2C+R%3BMiller%2C+M&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cosis.net/members/meetings/programme/session_programme.php? m_id=29 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Emergency response guidance for the first 48 hours after the outdoor detonation of an explosive radiological dispersal device AN - 17172652; 6832327 AB - Strategies and decisions to protect emergency responders, the public, and critical infrastructure against the effects of a radiological dispersal device detonated outdoors must be made in the planning stage, not in the early period just after an attack. This contrasts with planning for small-scale types of radiological or nuclear emergencies, or for a large-scale nuclear-power-type accident that evolves over many hours or days before radioactivity is released to the environment, such that its effects can be prospectively modeled and analyzed. By the time it is known an attack has occurred, most likely there will have been casualties, all the radioactive material will have been released, plume growth will be progressing, and there will be no time left for evaluating possible countermeasures. This paper offers guidance to planners, first responders, and senior decision makers to assist them in developing strategies for protective actions and operational procedures for the first 48 hours after an explosive radiological dispersal device has been detonated. JF - Health Physics AU - Musolino, S V AU - Harper, F T AD - Brookhaven National Laboratory, Nonproliferation and National Security Department, P.O. Box 5000, Upton, NY 11973-5000, USA, musolino@bnl.gov Y1 - 2006/04// PY - 2006 DA - Apr 2006 SP - 377 EP - 385 VL - 90 IS - 4 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Accidents KW - Radioactive fallout KW - Emergency preparedness KW - Explosives KW - Plumes KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17172652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Emergency+response+guidance+for+the+first+48+hours+after+the+outdoor+detonation+of+an+explosive+radiological+dispersal+device&rft.au=Musolino%2C+S+V%3BHarper%2C+F+T&rft.aulast=Musolino&rft.aufirst=S&rft.date=2006-04-01&rft.volume=90&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Accidents; Radioactive fallout; Emergency preparedness; Explosives; Plumes ER - TY - CPAPER T1 - Gadolinium-Doped Liquid Scintillator for New Reactor Antineutrino Experiments T2 - 231st National Meeting of the American Chemical Society AN - 40098783; 4115463 JF - 231st National Meeting of the American Chemical Society AU - Yeh, Minfang Y1 - 2006/03/26/ PY - 2006 DA - 2006 Mar 26 KW - Nuclear reactors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40098783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=231st+National+Meeting+of+the+American+Chemical+Society&rft.atitle=Gadolinium-Doped+Liquid+Scintillator+for+New+Reactor+Antineutrino+Experiments&rft.au=Yeh%2C+Minfang&rft.aulast=Yeh&rft.aufirst=Minfang&rft.date=2006-03-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=231st+National+Meeting+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/231nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quasiparticle breakdown in a quantum spin liquid AN - 19974279; 6736717 AB - Much of modern condensed matter physics is understood in terms of elementary excitations, or quasiparticles-fundamental quanta of energy and momentum. Various strongly interacting atomic systems are successfully treated as a collection of quasiparticles with weak or no interactions. However, there are interesting limitations to this description: in some systems the very existence of quasiparticles cannot be taken for granted. Like unstable elementary particles, quasiparticles cannot survive beyond a threshold where certain decay channels become allowed by conservation laws; their spectrum terminates at this threshold. Such quasiparticle breakdown was first predicted for an exotic state of matter-super-fluid super(4)He at temperatures close to absolute zero, a quantum Bose liquid where zero-point atomic motion precludes crystallization. Here we show, using neutron scattering, that quasiparticle breakdown can also occur in a quantum magnet and, by implication, in other systems with Bose quasiparticles. We have measured spin excitations in a two-dimensional quantum magnet, piperazinium hexachlorodicuprate (PHCC), in which spin-1/2 copper ions form a non-magnetic quantum spin liquid, and find remarkable similarities with excitations in superfluid super(4)He. We observe a threshold momentum beyond which the quasiparticle peak merges with the two-quasiparticle continuum. It then acquires a finite energy width and becomes indistinguishable from a leading-edge singularity, so that excited states are no longer quasiparticles but occupy a wide band of energy. Our findings have important ramifications for understanding excitations with gapped spectra in many condensed matter systems, ranging from band insulators to high-transition-temperature superconductors. JF - Nature AU - Stone, Matthew B AU - Zaliznyak, Igor A AU - Hong, Tao AU - Broholm, Collin L AU - Reich, Daniel H AD - Condensed Matter Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA, zaliznyak@bnl.gov Y1 - 2006/03/09/ PY - 2006 DA - 2006 Mar 09 SP - 187 EP - 190 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 440 IS - 7081 SN - 0028-0836, 0028-0836 KW - Sustainability Science Abstracts KW - Channels KW - Ions KW - Temperature KW - Conservation KW - Copper KW - Decay KW - Particulates KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Quasiparticle+breakdown+in+a+quantum+spin+liquid&rft.au=Stone%2C+Matthew+B%3BZaliznyak%2C+Igor+A%3BHong%2C+Tao%3BBroholm%2C+Collin+L%3BReich%2C+Daniel+H&rft.aulast=Stone&rft.aufirst=Matthew&rft.date=2006-03-09&rft.volume=440&rft.issue=7081&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04593 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Channels; Ions; Temperature; Conservation; Particulates; Decay; Copper DO - http://dx.doi.org/10.1038/nature04593 ER - TY - JOUR T1 - Recent progress in the syntheses and biological evaluation of boronated porphyrins for boron neutron-capture therapy. AN - 67736134; 16529537 AB - Boronated porphyrins are an important class of tumor-localizing agents in two bimodal therapies for cancer currently under study experimentally and clinically; boron neutron-capture therapy (BNCT) and photodynamic therapy (PDT). The desirable properties for the boronated porphyrins are that they are easily synthesized, pure and well-characterized drugs, and that in vivo, they are stable, tumor-specific, with high tumor:blood and tumor:normal tissue boron concentration ratios, and cause minimal toxicity. A large number of new porphyrins and their syntheses are presented herein. The focus is primarily on porphyrins published within the past 5 years, but the implications and trends from porphyrins studied in vivo over the past 15 years are also reviewed. Many possess quite unusual, novel structures and others have appended cell-targeting moieties for greater tumor specificity. Besides the commonly used closo- and nido-o-carboranes other boron cages and modes of attachment are presented. These boron cages can selectively alter the lipophilic, hydrophilic and amphiphilic properties of the porphyrins as well as their boron content. New delivery modalities have also greatly improved the targeting potential of compounds previously deemed unsuitable for applications in BNCT. JF - Anti-cancer agents in medicinal chemistry AU - Renner, M W AU - Miura, M AU - Easson, M W AU - Vicente, M G H AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 145 EP - 157 VL - 6 IS - 2 SN - 1871-5206, 1871-5206 KW - Antineoplastic Agents KW - 0 KW - Boron Compounds KW - Porphyrins KW - Index Medicus KW - Animals KW - Humans KW - Photochemotherapy -- methods KW - Porphyrins -- chemical synthesis KW - Antineoplastic Agents -- chemical synthesis KW - Boron Neutron Capture Therapy -- methods KW - Boron Compounds -- chemical synthesis KW - Boron Compounds -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Porphyrins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67736134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+agents+in+medicinal+chemistry&rft.atitle=Recent+progress+in+the+syntheses+and+biological+evaluation+of+boronated+porphyrins+for+boron+neutron-capture+therapy.&rft.au=Renner%2C+M+W%3BMiura%2C+M%3BEasson%2C+M+W%3BVicente%2C+M+G+H&rft.aulast=Renner&rft.aufirst=M&rft.date=2006-03-01&rft.volume=6&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+agents+in+medicinal+chemistry&rft.issn=18715206&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression. AN - 67646454; 16465372 AB - Multiple genetic alterations are common in cancers including those of the breast. The mechanisms leading to these alterations such as point mutations, gene amplifications, deletions and replication error are often associated with frequent and consistent loss of heterozygosity (LOH) or microsatellite instability (MSI). Several cytological and molecular studies have shown high frequency loss of genetic information on the long arm of chromosome 11 (i.e., 11q) in various primary breast cancers. In the present study allelic alterations in a refined position on the long arm of chromosome 11 were studied to identify the spectrum of induced damage at different stages of malignant transformation of MCF-10F cell lines after exposure to high-LET radiation using alpha-particles and exposure to estradiol by using PCR-single strand conformation polymorphism (SSCP) and fluorescence in situ hybridization (FISH) analysis. Microsatellite markers were selected from chromosome 11 (11q23-q24 loci) and it was found that frequency of allelic imbalance occurs at different stages of tumor progression with a range of 15-45% depending on the marker studied. These results strongly suggested the presence of several tumor suppressor genes in this critical region of chromosome 11 (11q23-q24). It also represents the first indication of allele loss at these loci in human breast epithelial cells induced by radiation and estrogen treatment suggesting a potential interventional target in breast carcinogenesis. JF - International journal of oncology AU - Roy, D AU - Calaf, G M AU - Hande, M P AU - Hei, T K AD - Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 11973, USA. droy@bnl.gov Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 667 EP - 674 VL - 28 IS - 3 SN - 1019-6439, 1019-6439 KW - Estrogens KW - 0 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Microsatellite Repeats -- genetics KW - Breast Neoplasms -- pathology KW - Humans KW - In Situ Hybridization, Fluorescence -- methods KW - Alpha Particles KW - Cell Line, Tumor KW - Cell Line, Transformed KW - Female KW - Loss of Heterozygosity KW - Estrogens -- pharmacology KW - Cell Transformation, Neoplastic -- radiation effects KW - Chromosomes, Human, Pair 11 -- genetics KW - Cell Transformation, Neoplastic -- drug effects KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67646454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Allelic+imbalance+at+11q23-q24+chromosome+associated+with+estrogen+and+radiation-induced+breast+cancer+progression.&rft.au=Roy%2C+D%3BCalaf%2C+G+M%3BHande%2C+M+P%3BHei%2C+T+K&rft.aulast=Roy&rft.aufirst=D&rft.date=2006-03-01&rft.volume=28&rft.issue=3&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-28 N1 - Date created - 2006-02-08 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The relationship between Cambrian-Ordovician high-TOC source rock development and paleoenvironment variations in the Tarim Basin, western China; carbon and oxygen isotope evidence AN - 50055182; 2010-031592 AB - Sedimentary elemental and isotopic records of seawater and its isotopic composition are the most promising recorders of the history of this planet on a geological time scale. The Tarim Basin of northwestern China contains thick marine Cambrian-Ordovician sediments. Stable carbon and oxygen isotope values of these sediments show that dramatic changes occurred in the Early Paleozoic. A drastic positive shift in carbon and oxygen isotopes at the boundary of the Precambrian and Cambrian suggests a remarkable cooling and drop in sea level occurred right before the transition. Then the beginning of the Cambrian or Paleozoic is marked by a rapid negative shift in both carbon and oxygen isotope values, suggesting a rapid warming of climate and large-scale rise in sea level. Drastic input of meteoric water is perhaps the major cause of the decrease in isotope values in these sediments. The optimal climate conditions of the Early Cambrian provide ideal conditions for the biological exploration of the Early Cambrian. Enhanced bioproduction in the Cambrian is shown also by the significantly higher TOC data. Severe fluctuations in climate and sea-level change as well as high TOC values marked the Early and Middle Cambrian. The later Cambrian and early Ordovician was probably a rather stable period of time in terms of climate and sea level in the region. By the end of the early Ordovician and the transition of the Early to Middle Ordovician, isotope signals were characterized by a severe negative shift. TOC reached a new high in the Middle Ordovician (from <0.5% to-5%), suggesting elevated bioproduction (and preservation). These lines of evidence all suggest enhanced climate conditions. The large volume of melted water from the nearby ice sheet brought in not only fresh water, but also nutrients, thus providing an optimal environment for another bioexplosion and optimal conditions for oil source formation. JF - Dizhixue Bao = Acta Geologica Sinica AU - Zhang, Shuichang AU - Wang, Ruiliang AU - Jin, Zhijun AU - Zhang, Baomin AU - Wang, Darui AU - Bian, Lizeng Y1 - 2006/03// PY - 2006 DA - March 2006 SP - 459 EP - 466 PB - Science Press, Beijing VL - 80 IS - 3 SN - 0001-5717, 0001-5717 KW - petroleum exploration KW - Far East KW - oxygen KW - isotopes KW - source rocks KW - stratigraphic traps KW - Xinjiang China KW - petroleum KW - paleoclimatology KW - stable isotopes KW - Cambrian KW - geochemical indicators KW - Ordovician KW - total organic carbon KW - carbon KW - depositional environment KW - Asia KW - geochemistry KW - China KW - Paleozoic KW - isotope ratios KW - C-13/C-12 KW - O-18/O-16 KW - Tarim Basin KW - organic compounds KW - paleoenvironment KW - productive capacity KW - marine environment KW - traps KW - 29A:Economic geology, geology of energy sources KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50055182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.atitle=The+relationship+between+Cambrian-Ordovician+high-TOC+source+rock+development+and+paleoenvironment+variations+in+the+Tarim+Basin%2C+western+China%3B+carbon+and+oxygen+isotope+evidence&rft.au=Zhang%2C+Shuichang%3BWang%2C+Ruiliang%3BJin%2C+Zhijun%3BZhang%2C+Baomin%3BWang%2C+Darui%3BBian%2C+Lizeng&rft.aulast=Zhang&rft.aufirst=Shuichang&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.issn=00015717&rft_id=info:doi/ LA - Chinese DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 22 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - TCHPAX N1 - SubjectsTermNotLitGenreText - Asia; C-13/C-12; Cambrian; carbon; China; depositional environment; Far East; geochemical indicators; geochemistry; isotope ratios; isotopes; marine environment; O-18/O-16; Ordovician; organic compounds; oxygen; paleoclimatology; paleoenvironment; Paleozoic; petroleum; petroleum exploration; productive capacity; source rocks; stable isotopes; stratigraphic traps; Tarim Basin; total organic carbon; traps; Xinjiang China ER - TY - JOUR T1 - Use of Single-Point Genome Signature Tags as a Universal Tagging Method for Microbial Genome Surveys AN - 19972858; 6750662 AB - We developed single-point genome signature tags (SP-GSTs), a generally applicable, high-throughput sequencing-based method that targets specific genes to generate identifier tags from well-defined points in a genome. The technique yields identifier tags that can distinguish between closely related bacterial strains and allow for the identification of microbial community members. SP-GSTs are determined by three parameters: (i) the primer designed to recognize a conserved gene sequence, (ii) the anchoring enzyme recognition sequence, and (iii) the type IIS restriction enzyme which defines the tag length. We evaluated the SP-GST method in silico for bacterial identification using the genes rpoC, uvrB, and recA and the 16S rRNA gene. The best distinguishing tags were obtained with the restriction enzyme Csp6I upstream of the 16S rRNA gene, which discriminated all organisms in our data set to at least the genus level and most organisms to the species level. The method was successfully used to generate Csp6I-based tags upstream of the 16S rRNA gene and allowed us to discriminate between closely related strains of Bacillus cereus and Bacillus anthracis. This concept was further used successfully to identify the individual members of a defined microbial community. JF - Applied and Environmental Microbiology AU - van der Lelie, Daniel AU - Lesaulnier, Celine AU - McCorkle, Sean AU - Geets, Joke AU - Taghavi, Safiyh AU - Dunn, John AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, New York 11973. IRD, UR 101, IFR-BAIM, Universite de Provence, ESIL, F-13288 Marseille Cedex 09, France. and Universiteit Hasselt, Environmental Sciences, Building D, Universitaire Campus, Diepenbeek B3590, Belgium Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 2092 EP - 2101 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 72 IS - 3 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Data processing KW - Bacillus cereus KW - Conserved sequence KW - Enzymes KW - Primers KW - Bacillus anthracis KW - rRNA 16S KW - RecA protein KW - A 01450:Environmental Pollution & Waste Treatment KW - W 30965:Miscellaneous, Reviews KW - G 07770:Bacteria KW - W2 32243:Molecular methods KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19972858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Use+of+Single-Point+Genome+Signature+Tags+as+a+Universal+Tagging+Method+for+Microbial+Genome+Surveys&rft.au=van+der+Lelie%2C+Daniel%3BLesaulnier%2C+Celine%3BMcCorkle%2C+Sean%3BGeets%2C+Joke%3BTaghavi%2C+Safiyh%3BDunn%2C+John&rft.aulast=van+der+Lelie&rft.aufirst=Daniel&rft.date=2006-03-01&rft.volume=72&rft.issue=3&rft.spage=2092&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Enzymes; Conserved sequence; Primers; rRNA 16S; RecA protein; Bacillus cereus; Bacillus anthracis ER - TY - JOUR T1 - Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate AN - 17156854; 6765765 AB - Mycobacterium tuberculosis (Mtb) has the remarkable ability to resist killing by human macrophages. The 750 kDa proteasome, not available in most eubacteria except Actinomycetes, appears to contribute to Mtb's resistance. The crystal structure of the Mtb proteasome at 3.0 Aa resolution reveals a substrate-binding pocket with composite features of the distinct beta 1, beta 2 and beta 5 substrate binding sites of eukaryotic proteasomes, accounting for the broad specificity of the Mtb proteasome towards oligopeptides described in the companion article [Lin et al. (2006), Mol Microbiol doi:10.1111-j.1365-2958.2005.05035.x]. The substrate entrance at the end of the cylindrical proteasome appears open in the crystal structure due to partial disorder of the alpha -subunit N-terminal residues. However, cryo-electron microscopy of the core particle reveals a closed end, compatible with the density observed in negative-staining electron microscopy that depended on the presence of the N-terminal octapetides of the alpha -subunits in the companion article, suggesting that the Mtb proteasome has a gated structure. We determine for the first time the proteasomal inhibition mechanism of the dipeptidyl boronate N-(4-morpholine)carbonyl- beta -(1-naphthyl) -l-alanine-l-leucine boronic acid (MLN-273), an analogue of the antimyeloma drug bortezomib. The structure improves prospects for designing Mtb-specific proteasomal inhibitors as a novel approach to chemotherapy of tuberculosis. JF - Molecular Microbiology AU - Hu, Guiqing AU - Lin, Gang AU - Wang, Ming AU - Dick, Lawrence AU - Xu, Rui-Ming AU - Nathan, Carl AU - Li, Huilin AD - Biology Department, Brookhaven National Laboratory, 50 Bell Avenue, Upton, NY 11973, USA, hli@bnl.gov Y1 - 2006/03// PY - 2006 DA - Mar 2006 SP - 1417 EP - 1428 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 59 IS - 5 SN - 0950-382X, 0950-382X KW - peptidyl boronate KW - Microbiology Abstracts B: Bacteriology KW - Eubacterium KW - Macrophages KW - Core particles KW - Chemotherapy KW - proteasomes KW - Crystal structure KW - Oligopeptides KW - Drugs KW - Electron microscopy KW - Actinomycetes KW - Mycobacterium tuberculosis KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17156854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure+of+the+Mycobacterium+tuberculosis+proteasome+and+mechanism+of+inhibition+by+a+peptidyl+boronate&rft.au=Hu%2C+Guiqing%3BLin%2C+Gang%3BWang%2C+Ming%3BDick%2C+Lawrence%3BXu%2C+Rui-Ming%3BNathan%2C+Carl%3BLi%2C+Huilin&rft.aulast=Hu&rft.aufirst=Guiqing&rft.date=2006-03-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - SuppNotes - Figures, 6; tables, 2; references, 42. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Chemotherapy; Core particles; Crystal structure; proteasomes; Drugs; Oligopeptides; Actinomycetes; Electron microscopy; Eubacterium; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1111/j.1365-2958.2005.05036.x ER - TY - CPAPER T1 - Behavior of Radionuclides and RCRA Elements in Tank Backfill Grouts T2 - 32nd annual Waste Management Symposia: HLW, TRU, LLW/ILW, Mixed, Hazardous Wastes and Environmental Management (WM 06) AN - 39891129; 4143476 JF - 32nd annual Waste Management Symposia: HLW, TRU, LLW/ILW, Mixed, Hazardous Wastes and Environmental Management (WM 06) AU - Fuhrmann, Mark AU - Gillow, Jeffrey AU - Westcott, Daniel Y1 - 2006/02/26/ PY - 2006 DA - 2006 Feb 26 KW - Waste management KW - Environmental regulations KW - RCRA KW - Government regulations KW - Hazardous wastes KW - Legislation KW - Federal regulations KW - Radioisotopes KW - U 4300:Environmental Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=32nd+annual+Waste+Management+Symposia%3A+HLW%2C+TRU%2C+LLW%2FILW%2C+Mixed%2C+Hazardous+Wastes+and+Environmental+Management+%28WM+06%29&rft.atitle=Behavior+of+Radionuclides+and+RCRA+Elements+in+Tank+Backfill+Grouts&rft.au=Fuhrmann%2C+Mark%3BGillow%2C+Jeffrey%3BWestcott%2C+Daniel&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2006-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=32nd+annual+Waste+Management+Symposia%3A+HLW%2C+TRU%2C+LLW%2FILW%2C+Mixed%2C+Hazardous+Wastes+and+Environmental+Management+%28WM+06%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wmsym.org/pdf/WM06_Preliminary_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Using Lidar to Measure Perfluorocarbon Tracers for the Verification and Monitoring of Cap and Cover Systems AN - 877599065; 13727166 AB - Waste site cover systems used to prevent rainfall from reaching the waste need to remain intact throughout the lifetime of the waste site. Monitoring of these covers is needed to ascertain the performance and to determine if any degradation has occurred. Researchers at Brookhaven National Laboratory have used gaseous perfluorocarbon tracers (PFTs) to monitor the integrity of caps and covers for waste disposal sites. Detection of the PFTs currently uses gas chromatography techniques developed at BNL. This paper presents a potential approach to this wide-area screening problem by replacing conventional gas chromatography analysis with laser-based, lidar (Light Detection and Ranging) detection of the PFTs. Lidar can be used to scan the surface of the cover system, looking for fugitive PFTs. If successful this would enable the departure from soil gas analysis and instead look for PFTs in the air just above the soil surface. The advantages of using a lidar platform are multi-fold and include the elimination of soil monitoring ports. Benchtop and pilot-scale indoor experiments using an a continuous wave, line-tunable infrared CO sub(2) laser were used to detect PMCH (perfluoromethylcyclohexane, one of a group of PFTs used at BNL). Laboratory measurements of the absorption cross-section were the same order of magnitude compared to literature values for similar perfluorocarbon compounds. Initial benchtop, fixed cell length experiments were successful in detecting PMCH to levels of 10 ppb-m. To improve the lower limit of detection, a HgCdTe detector was purchased that was more specific to the lasing region of interest and hence had a higher sensitivity at this spectral region Using a pilot-scale lidar system in a 40m indoor hallway air concentrations of PMCH were then measured down to 1 ppb-m. These results are very promising and show great potential for monitoring the integrity of cover systems using lidar and PFTs. JF - Water, Air, & Soil Pollution AU - Heiser, John H AU - Sedlacek, Arthur J AD - Brookhaven National Laboratory, New York, USA, heiser@bnl.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 345 EP - 357 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 170 IS - 1-4 SN - 0049-6979, 0049-6979 KW - Environment Abstracts; Pollution Abstracts KW - Absorption KW - Lidar KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877599065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Using+Lidar+to+Measure+Perfluorocarbon+Tracers+for+the+Verification+and+Monitoring+of+Cap+and+Cover+Systems&rft.au=Heiser%2C+John+H%3BSedlacek%2C+Arthur+J&rft.aulast=Heiser&rft.aufirst=John&rft.date=2006-02-01&rft.volume=170&rft.issue=1-4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-005-9007-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Lidar DO - http://dx.doi.org/10.1007/s11270-005-9007-8 ER - TY - JOUR T1 - ALARA considerations for the whole body neutron irradiation facility source removal project at Brookhaven National Laboratory. AN - 70684729; 16404183 AB - This paper describes the activities that were involved with the safe removal of fourteen PuBe sources from the Brookhaven National Laboratory (BNL) Whole Body Neutron Irradiation Facility (WBNIF). As part of a Department of Energy and BNL effort to reduce the radiological inventory, the WBNIF was identified as having no future use. In order to deactivate the facility and eliminate the need for nuclear safety management and long-term surveillance, it was decided to remove the neutron sources and dismantle the facility. In addition, the sources did not have DOT Special Form documentation so they would need to be encapsulated once removed for offsite storage or disposal. The planning and the administrative as well as engineering controls put in place enabled personnel to safely remove and encapsulate the sources while keeping exposure as low as reasonably achievable (ALARA). JF - Health physics AU - Sullivan, Patrick T AD - Brookhaven National Laboratory, PO Box 5000, Building 860, Upton, NY 11973, USA. sulli@bnl.gov Y1 - 2006/02// PY - 2006 DA - February 2006 SP - S18 EP - S23 VL - 90 IS - 2 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - Whole-Body Irradiation KW - Humans KW - Environmental Pollution -- prevention & control KW - Decontamination -- methods KW - Radiation Dosage KW - Radiation Monitoring -- standards KW - Radiation Monitoring -- methods KW - Safety Management -- methods KW - Health Facility Closure -- methods KW - Laboratories KW - Radioactive Waste -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70684729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=ALARA+considerations+for+the+whole+body+neutron+irradiation+facility+source+removal+project+at+Brookhaven+National+Laboratory.&rft.au=Sullivan%2C+Patrick+T&rft.aulast=Sullivan&rft.aufirst=Patrick&rft.date=2006-02-01&rft.volume=90&rft.issue=2+Suppl&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Structures of wild-type and mutant human spermidine/spermine N super(1)-acetyltransferase, a potential therapeutic drug target AN - 19766981; 6715033 AB - Spermidine/spermine N super(1)-acetyltransferase (SSAT) is a key enzyme in the control of polyamine levels in human cells, as acetylation of spermidine and spermine triggers export or degradation. Increased intracellular polyamine levels accompany several types of cancers as well as other human diseases, and compounds that affect the expression, activity, or stability of SSAT are being explored as potential therapeutic drugs. We have expressed human SSAT from the cloned cDNA in Escherichia coli and have determined high-resolution structures of wild-type and mutant SSAT, as the free dimer and in binary and ternary complexes with CoA, acetyl-CoA (AcCoA), spermine, and the inhibitor N super(1),N super(11)-bis-(ethyl)-norspermine (BE-3-3-3). These structures show details of binding sites for cofactor, substrates, and inhibitor and provide a framework to understand enzymatic activity, mutations, and the action of potential drugs. Two dimer conformations were observed: a symmetric form with two open surface channels capable of binding substrate or cofactor, and an asymmetric form in which only one of the surface channels appears capable of binding and acetylating polyamines. SSAT was found to self-acetylate lysine-26 in the presence of AcCoA and absence of substrate, a reaction apparently catalzyed by AcCoA bound in the second channel of the asymmetric dimer. These unexpected and intriguing complexities seem likely to have some as yet undefined role in regulating SSAT activity or stability as a part of polyamine homeostasis. Sequence signatures group SSAT with proteins that appear to have thialysine N super( epsilon )-acetyltransferase activity. JF - Proceedings of the National Academy of Sciences, USA AU - Bewley, Maria C AU - Graziano, Vito AU - Jiang, Jiangsheng AU - Matz, Eileen AU - Studier, FWilliam AU - Pegg, Anthony E AU - Coleman, Catherine S AU - Flanagan, John M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 2063 EP - 2068 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 7 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Spermine KW - Enzymes KW - Homeostasis KW - Cancer KW - Acetylation KW - Cofactors KW - Spermidine KW - polyamines KW - Escherichia coli KW - N1-acetyltransferase KW - Enzymatic activity KW - Mutation KW - Drugs KW - Conformation KW - J 02310:Genetics & Taxonomy KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Structures+of+wild-type+and+mutant+human+spermidine%2Fspermine+N+super%281%29-acetyltransferase%2C+a+potential+therapeutic+drug+target&rft.au=Bewley%2C+Maria+C%3BGraziano%2C+Vito%3BJiang%2C+Jiangsheng%3BMatz%2C+Eileen%3BStudier%2C+FWilliam%3BPegg%2C+Anthony+E%3BColeman%2C+Catherine+S%3BFlanagan%2C+John+M&rft.aulast=Bewley&rft.aufirst=Maria&rft.date=2006-02-01&rft.volume=103&rft.issue=7&rft.spage=2063&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Spermine; Enzymes; Homeostasis; Cancer; Acetylation; Cofactors; Spermidine; polyamines; N1-acetyltransferase; Enzymatic activity; Drugs; Mutation; Conformation; Escherichia coli ER - TY - JOUR T1 - Spectrum of Complex DNA Damages Depends on the Incident Radiation AN - 17476568; 6658391 AB - Ionizing radiation induces bistranded clustered damages- two or more abasic sites, oxidized bases and strand breaks on opposite DNA strands within a few helical turns. Since clusters are refractory to repair and are potential sources of double-strand breaks (DSBs), they are potentially lethal and mutagenic. Although induction of single-strand breaks (SSBs) and isolated lesions has been studied extensively, little is known about the factors affecting induction of clusters other than DSBs. To determine whether the type of incident radiation could affect the yields or spectra of specific clusters, we irradiated genomic T7 DNA, a simple 40-kbp linear, blunt-ended molecule, with ion beams [iron (970 MeV/nucleon), carbon (293 MeV/nucleon), titanium (980 MeV/nucleon), silicon (586 MeV/nucleon), protons (1 GeV/nucleon)] or 100 kVp X rays and then quantified DSBs, Fpg-oxypurine clusters and Nfo-abasic clusters using gel electrophoresis, electronic imaging and number average length analysis. The yields (damages/Mbp Gy super(-1)) of all damages decreased with increasing linear energy transfer (LET) of the radiation. The relative frequencies of DSBs compared to abasic and oxybase clusters were higher for the charged particles-including the high-energy, low-LET protons-than for the ionizing photons. JF - Radiation Research AU - Hada, M AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000 Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 223 EP - 230 PB - The Radiation Research Society VL - 165 IS - 2 SN - 0033-7587, 0033-7587 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Silicon KW - Titanium KW - Photons KW - Protons KW - Double-strand break repair KW - imaging KW - Gel electrophoresis KW - DNA damage KW - Carbon KW - Ionizing radiation KW - genomics KW - Iron KW - X 24210:Radiation & radioactive materials KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17476568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Spectrum+of+Complex+DNA+Damages+Depends+on+the+Incident+Radiation&rft.au=Hada%2C+M%3BSutherland%2C+B+M&rft.aulast=Hada&rft.aufirst=M&rft.date=2006-02-01&rft.volume=165&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282006%291652.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=165&issue=2&page=223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA damage; Titanium; Silicon; Carbon; Photons; Protons; Ionizing radiation; genomics; Double-strand break repair; Iron; imaging; Gel electrophoresis DO - http://dx.doi.org/10.1043/0033-7587(2006)165[223:SOCDDD]2.0.CO;2 ER - TY - JOUR T1 - A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies AN - 17457446; 6647401 AB - Using positron emission tomography (PET) with a specific and selective radioligand targeting nicotinic acetylcholine receptor (nAChR) would allow us to better understand various nAChR related CNS disorders. The use of radiolabeled nAChR antagonists would provide a much safer pharmacological profile, avoiding most peripheral side effects that might be generated from radiolabeled nAChR agonists even at the tracer level; thus, PET imaging with nAChR antagonists would facilitate clinical application. A potent and selective nAChR antagonist was labeled and characterized with PET in non-human primates. Its high brain uptake, high signal-to-noise ratio, and high specific binding strongly suggest a great potential to carry out imaging studies in humans. In addition, the use of a C-11 radiotracer would allow us to perform multiple PET studies in the same individual within a short time frame. The presence of an iodine atom in the molecule also allows the possibility to label with radioiodine for SPECT studies. JF - Bioorganic and Medicinal Chemistry Letters AU - Ding, Yu-Shin AU - Kil, Kun-Eek AU - Lin, Kuo-Shyan AU - Ma, Wei AU - Yokota, Yasuno AU - Carroll, Ivy F AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA, ding@bnl.gov Y1 - 2006/02// PY - 2006 DA - Feb 2006 SP - 1049 EP - 1053 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 4 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Tracers KW - Central nervous system KW - Neuroimaging KW - Brain KW - Positron emission tomography KW - Iodine KW - Side effects KW - Acetylcholine receptors (nicotinic) KW - Single photon emission computed tomography KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17457446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=A+novel+nicotinic+acetylcholine+receptor+antagonist+radioligand+for+PET+studies&rft.au=Ding%2C+Yu-Shin%3BKil%2C+Kun-Eek%3BLin%2C+Kuo-Shyan%3BMa%2C+Wei%3BYokota%2C+Yasuno%3BCarroll%2C+Ivy+F&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2006-02-01&rft.volume=16&rft.issue=4&rft.spage=1049&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2005.10.075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Acetylcholine receptors (nicotinic); Positron emission tomography; Neuroimaging; Central nervous system; Side effects; Brain; Single photon emission computed tomography; Tracers; Iodine DO - http://dx.doi.org/10.1016/j.bmcl.2005.10.075 ER - TY - CPAPER T1 - Regional and Seasonal Variations in Marine Stratus Cloud Properties from MODIS Observations T2 - 14th Conference on Satellite Meteorology and Oceanography AN - 39764455; 4057016 JF - 14th Conference on Satellite Meteorology and Oceanography AU - Jensen, Michael P AU - Andrew, V D AU - Collins, W D AU - Zhang, G J AU - Luke, E Y1 - 2006/01/29/ PY - 2006 DA - 2006 Jan 29 KW - Seasonal variations KW - Clouds KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Conference+on+Satellite+Meteorology+and+Oceanography&rft.atitle=Regional+and+Seasonal+Variations+in+Marine+Stratus+Cloud+Properties+from+MODIS+Observations&rft.au=Jensen%2C+Michael+P%3BAndrew%2C+V+D%3BCollins%2C+W+D%3BZhang%2C+G+J%3BLuke%2C+E&rft.aulast=Jensen&rft.aufirst=Michael&rft.date=2006-01-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Conference+on+Satellite+Meteorology+and+Oceanography&rft.issn=&rft_id=info:doi/ L2 - http://ams.confex.com/ams/Annual2006/techprogram/program_312.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Crystal Structure of AqpZ Tetramer Reveals Two Distinct Arg-189 Conformations Associated with Water Permeation through the Narrowest Constriction of the Water-conducting Channel AN - 17468049; 6661144 AB - AqpZ is a homotetramer of four water-conducting channels that facilitate rapid water movements across the plasma membrane of Escherichia coli. Here we report a 3.2 Aa crystal structure of the tetrameric AqpZ (tAqpZ). All channel-lining residues in the four monomeric channels are found orientated in nearly identical positions with one marked exception at the narrowest channel constriction, where the side chain of a highly conserved Arg-189 adopts two distinct conformational orientations. In one of the four monomers, the guanidino group of Arg-189 points toward the periplasmic vestibule, opening up the constriction to accommodate the binding of a water molecule through a tridentate H-bond. In the other three monomers, the Arg-189 guanidino group bends over to form an H-bond with carbonyl oxygen of the Thr-183, thus occluding the channel. Therefore, the tAqpZ structure reveals two distinct Arg-189 confirmations associated with water permeation through the channel constrictions. Alternation between the two Arg-189 conformations disrupts continuous flow of water, thus regulating the open probability of the water pore. Further, the difference in Arg-189 displacements is correlated with a strong electron density found between the first transmembrane helices of two open channels, suggesting that the observed Arg-189 conformations are stabilized by asymmetrical subunit interactions in tAqpZ. JF - Journal of Biological Chemistry AU - Jiang, Jiansheng AU - Daniels, Brenda V AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2006/01/06/ PY - 2006 DA - 2006 Jan 06 SP - 454 EP - 460 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 1 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Monomers KW - Oxygen KW - AqpZ protein KW - Plasma membranes KW - Channel pores KW - Channel opening KW - Escherichia coli KW - Crystal structure KW - carbonyls KW - Water KW - Conformational analysis KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17468049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Crystal+Structure+of+AqpZ+Tetramer+Reveals+Two+Distinct+Arg-189+Conformations+Associated+with+Water+Permeation+through+the+Narrowest+Constriction+of+the+Water-conducting+Channel&rft.au=Jiang%2C+Jiansheng%3BDaniels%2C+Brenda+V%3BFu%2C+Dax&rft.aulast=Jiang&rft.aufirst=Jiansheng&rft.date=2006-01-06&rft.volume=281&rft.issue=1&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Monomers; Oxygen; AqpZ protein; Plasma membranes; Channel pores; Channel opening; Crystal structure; carbonyls; Water; Conformational analysis; Escherichia coli ER - TY - JOUR T1 - DNA damage quantitation by alkaline gel electrophoresis. AN - 67930543; 16673887 AB - Quantifying DNA lesions provides a powerful way to assess the level of endogenous damage or the damage level induced by radiation, chemical or other agents, as well as the ability of cells to repair such damages. Quantitative gel electrophoresis of experimental DNAs along with DNA length standards, imaging the resulting dispersed DNA and calculating the population average length allows accurate measurement of lesion frequencies. Number average length analysis provides high sensitivity and does not require any specific distribution of lesions within the DNA molecules. These methods are readily applicable to strand breaks and ultraviolet radiation induced pyrimidine dimers, but can also be used-with appropriate modifications-for ionizing radiation-induced lesions such as oxidized bases and abasic sites. JF - Methods in molecular biology (Clifton, N.J.) AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Sutherland, John C AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2006 PY - 2006 DA - 2006 SP - 251 EP - 273 VL - 314 SN - 1064-3745, 1064-3745 KW - Pyrimidine Dimers KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Ultraviolet Rays KW - Cells, Cultured KW - Humans KW - Pyrimidine Dimers -- analysis KW - DNA Damage KW - Electrophoresis, Agar Gel -- standards KW - DNA -- chemistry KW - DNA -- radiation effects KW - Comet Assay -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67930543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.atitle=DNA+damage+quantitation+by+alkaline+gel+electrophoresis.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BSutherland%2C+John+C&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2006-01-01&rft.volume=314&rft.issue=&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Methods+in+molecular+biology+%28Clifton%2C+N.J.%29&rft.issn=10643745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-06 N1 - Date created - 2006-05-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - An FTIR study of hydrogen in anorthoclase and associated melt inclusions AN - 51619032; 2006-022851 AB - High-resolution Fourier transform infrared (FTIR) spectroscopy has been used to document the presence of hydrogen, to estimate its concentration, and to document its oxygen speciation in anorthoclase crystals and associated melt inclusions from Mount Erebus, Antarctica. Synchrotron-generated infrared radiation, 100 to 1000 times brighter than globar-generated infrared radiation, permits rapid collection of maps that depict relative intensities of a chosen FTIR band across the mapped area. Spectra and/or compositional maps showing variations in water concentration were collected from anorthoclase megacrysts and melt inclusions in the megacrysts. Studies of anorthoclase megacrysts involved collection of spectra from three mutually perpendicular sections cut from the crystals. FTIR spectra of anorthoclase crystals are characterized by a broad absorption band at approximately 3200 cm (super -1) in the mid-IR range. The universal mass absorption coefficient for mid-IR range feldspar spectra, established by Johnson and Rossman (2003), was used for quantitative estimates of water concentrations in the feldspar crystals based on integrated area under the 3200 cm (super -1) band. Water concentration in the anorthoclase sample was approximately 126 ppm, with an overall error of approximately + or -30%. FTIR spectra of melt inclusions are characterized by a broad asymmetric absorption band at approximately 3550 cm (super -1) that was used to calculate total water concentration. The absence of a band at 1630 cm (super -1) suggests that water in the melt inclusions occurs as OH (super -) rather than as molecular H (sub 2) O. Absorption coefficients established by Mandeville et al. (2002) for H species in glass were used to calculate water concentrations in the melt inclusions. Melt inclusions in the Mt. Erebus anorthoclase have water concentrations ranging from 0.12 to 0.39 wt%, with an overall error of approximately + or -15%. The ratio of water in anorthoclase crystals to water in the melt from which the crystals formed, based on this study, and at these low melt water concentrations, is approximately 1:10. However, water concentration varies significantly from one melt inclusion to another, possibly suggesting initial melt water heterogeneity. Maps of water concentration show that variations in water concentration within melt inclusions are associated with fractures that cut the melt inclusions and in some cases do not extend out into surrounding crystals or into crystal inclusions. Thin (approximately 50 mu m thick) zones of elevated water concentrations on the boundaries of the crystals in contact with melt inclusions suggest that water has diffused into the crystals from the melt inclusions. JF - American Mineralogist AU - Seaman, Sheila J AU - Dyar, M Darby AU - Marinkovic, Nebojsa AU - Dunbar, Nelia W Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 12 EP - 20 PB - Mineralogical Society of America, Washington, DC VL - 91 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - volcanic rocks KW - igneous rocks KW - anorthoclase KW - phonolites KW - melt inclusions KW - infrared spectra KW - FTIR spectra KW - Antarctica KW - alkali feldspar KW - hydrogen KW - inclusions KW - framework silicates KW - fluid inclusions KW - spectra KW - feldspar group KW - phenocrysts KW - megacrysts KW - Mount Erebus KW - 01B:Mineralogy of silicates KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51619032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=An+FTIR+study+of+hydrogen+in+anorthoclase+and+associated+melt+inclusions&rft.au=Seaman%2C+Sheila+J%3BDyar%2C+M+Darby%3BMarinkovic%2C+Nebojsa%3BDunbar%2C+Nelia+W&rft.aulast=Seaman&rft.aufirst=Sheila&rft.date=2006-01-01&rft.volume=91&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2006.1765 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Abstract, copyright, Mineralogical Society of America | Reference includes data from GeoScienceWorld, Alexandria, VA, United States N1 - Date revised - 2006-01-01 N1 - Number of references - 48 N1 - PubXState - DC N1 - Document feature - illus. incl. table N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - alkali feldspar; anorthoclase; Antarctica; feldspar group; fluid inclusions; framework silicates; FTIR spectra; hydrogen; igneous rocks; inclusions; infrared spectra; megacrysts; melt inclusions; Mount Erebus; phenocrysts; phonolites; silicates; spectra; volcanic rocks DO - http://dx.doi.org/10.2138/am.2006.1765 ER - TY - JOUR T1 - A climatologically significant aerosol longwave indirect effect in the Arctic AN - 51251933; 2008-067052 JF - Nature (London) AU - Lubin, D AU - Vogelmann, A M Y1 - 2006/01// PY - 2006 DA - January 2006 SP - 453 EP - 456 PB - Macmillan Journals, London VL - 439 IS - 7075 SN - 0028-0836, 0028-0836 KW - clouds KW - albedo KW - monitoring KW - pollutants KW - human activity KW - Arctic region KW - sea ice KW - pollution KW - atmosphere KW - global change KW - environmental effects KW - climate change KW - temperature KW - air pollution KW - ice KW - solar radiation KW - aerosols KW - greenhouse effect KW - climate KW - meltwater KW - global warming KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51251933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+%28London%29&rft.atitle=A+climatologically+significant+aerosol+longwave+indirect+effect+in+the+Arctic&rft.au=Lubin%2C+D%3BVogelmann%2C+A+M&rft.aulast=Lubin&rft.aufirst=D&rft.date=2006-01-01&rft.volume=439&rft.issue=7075&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Nature+%28London%29&rft.issn=00280836&rft_id=info:doi/ L2 - http://www.nature.com/nature/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 27 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - NATUAS N1 - SubjectsTermNotLitGenreText - aerosols; air pollution; albedo; Arctic region; atmosphere; climate; climate change; clouds; environmental effects; global change; global warming; greenhouse effect; human activity; ice; meltwater; monitoring; pollutants; pollution; sea ice; solar radiation; temperature ER - TY - JOUR T1 - Mineralogy and petrology of comet Wild2 nucleus samples AN - 50274063; 2007-046373 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Zolensky, Michael AU - Bland, Phil AU - Bradley, John AU - Brearley, Adrian J AU - Brennan, Sean AU - Bridges, John AU - Brownlee, Donald AU - Butterworth, Anna L AU - Dai, Zurong AU - Ebel, Denton AU - Genge, Matt AU - Gounelle, Matthieu AU - Graham, Giles AU - Grossman, Lawrence AU - Harvey, Ralph P AU - Ishii, Hope AU - Kearsley, Anton AU - Keller, Lindsay AU - Krot, Alexander N AU - Lanzirotti, Antonio AU - Leroux, Hugues AU - Messenger, Keiko AU - Mikouchi, Takashi AU - Nakamura, Tomoki AU - Ohsumi, Kazumasa AU - Okudaira, Kyoko AU - Perronnet, Murielle AU - Rietmeijer, Frans AU - Simon, Steven AU - Stephan, Thomas AU - Stroud, Rhonda AU - Taheri, Mitra AU - Tomeoka, Kazu AU - Toppani, Alice AU - Tsou, Peter AU - Tsuchiyama, Akira AU - Webber, Iris AU - Weisberg, Mike AU - Westphal, Andrew J AU - Yano, Hajime AU - Zega, Thomas AU - Anonymous Y1 - 2006 PY - 2006 DA - 2006 EP - unpaginated PB - Lunar and Planetary Science Conference, Houston, TX VL - 37 KW - methods KW - laboratory studies KW - mineral composition KW - comets KW - Stardust Mission KW - Wild Comet KW - nucleus KW - interplanetary dust KW - samples KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50274063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Mineralogy+and+petrology+of+comet+Wild2+nucleus+samples&rft.au=Zolensky%2C+Michael%3BBland%2C+Phil%3BBradley%2C+John%3BBrearley%2C+Adrian+J%3BBrennan%2C+Sean%3BBridges%2C+John%3BBrownlee%2C+Donald%3BButterworth%2C+Anna+L%3BDai%2C+Zurong%3BEbel%2C+Denton%3BGenge%2C+Matt%3BGounelle%2C+Matthieu%3BGraham%2C+Giles%3BGrossman%2C+Lawrence%3BHarvey%2C+Ralph+P%3BIshii%2C+Hope%3BKearsley%2C+Anton%3BKeller%2C+Lindsay%3BKrot%2C+Alexander+N%3BLanzirotti%2C+Antonio%3BLeroux%2C+Hugues%3BMessenger%2C+Keiko%3BMikouchi%2C+Takashi%3BNakamura%2C+Tomoki%3BOhsumi%2C+Kazumasa%3BOkudaira%2C+Kyoko%3BPerronnet%2C+Murielle%3BRietmeijer%2C+Frans%3BSimon%2C+Steven%3BStephan%2C+Thomas%3BStroud%2C+Rhonda%3BTaheri%2C+Mitra%3BTomeoka%2C+Kazu%3BToppani%2C+Alice%3BTsou%2C+Peter%3BTsuchiyama%2C+Akira%3BWebber%2C+Iris%3BWeisberg%2C+Mike%3BWestphal%2C+Andrew+J%3BYano%2C+Hajime%3BZega%2C+Thomas%3BAnonymous&rft.aulast=Zolensky&rft.aufirst=Michael&rft.date=2006-01-01&rft.volume=37&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.lpi.usra.edu/meetings/lpsc2006/pdf/1203.pdf LA - English DB - GeoRef N1 - Conference title - Thirty-seventh lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 2 N1 - PubXState - TX N1 - SuppNotes - Accessed on Dec. 8, 2006 N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - comets; interplanetary dust; laboratory studies; methods; mineral composition; nucleus; samples; Stardust Mission; Wild Comet ER - TY - JOUR T1 - Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires" AN - 21345633; 7014035 AB - Phosphatidylglycerophosphatase (PGPase), an enzyme involved in lipid metabolism, catalyzes formation of phosphatidylglycerol from phosphatidylglycerophosphate. Phosphatidylglycerol is a multifunctional phospholipid, found in the biological membranes of many organisms. Here, we report the crystal structure of Listeria monocytogenes PGPase at 1.8 Aa resolution. PGPase, an all-helical molecule, forms a homotetramer. Each protomer contains an independent active site with two metal ions, Ca super(2+) and Mg super(2+), forming a hetero-binuclear center located in a hydrophilic cavity near the surface of the molecule. The binuclear center, conserved ligands, metal-bound water molecules, and an Asp-His dyad form the active site. The catalytic mechanism of this enzyme is likely to proceed via binuclear metal activated nucleophilic water. The binuclear metal-binding active-site environment of this structure should provide insights into substrate binding and metal-dependent catalysis. A long channel with inter-linked linear water chains, termed "proton wires," is observed at the tetramer interface. Comparison of similar water chain structures in photosynthetic reaction centers (RCs), Cytochrome f, gramicidin, and bacteriorhodopsin, suggests that PGPase may conduct protons via proton wires. Proteins 2006. JF - Proteins: Structure, Function and Bioinformatics AU - Kumaran, Desigan AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 851 EP - 862 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 64 IS - 4 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology KW - binuclear metal site lipid metabolism phosphatase proton wires PGPase KW - Phosphatidylglycerophosphatase KW - Listeria monocytogenes KW - Cytochromes KW - Ions KW - Metals KW - Gramicidin KW - Calcium KW - Protons KW - phosphatidylglycerol KW - Enzymes KW - Lipid metabolism KW - Protein structure KW - Bacteriorhodopsin KW - Crystal structure KW - Bioinformatics KW - Magnesium KW - Phospholipids KW - Catalysis KW - Reaction centers KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.atitle=Crystal+structure+of+phosphatidylglycerophosphatase+%28PGPase%29%2C+a+putative+membrane-bound+lipid+phosphatase%2C+reveals+a+novel+binuclear+metal+binding+site+and+two+%22proton+wires%22&rft.au=Kumaran%2C+Desigan%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Kumaran&rft.aufirst=Desigan&rft.date=2006-01-01&rft.volume=64&rft.issue=4&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+and+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.21039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Phosphatidylglycerophosphatase; Metals; Ions; Cytochromes; Gramicidin; Calcium; Protons; phosphatidylglycerol; Enzymes; Lipid metabolism; Protein structure; Bacteriorhodopsin; Crystal structure; Bioinformatics; Magnesium; Reaction centers; Catalysis; Phospholipids; Listeria monocytogenes DO - http://dx.doi.org/10.1002/prot.21039 ER - TY - JOUR T1 - MicroPET investigation of chronic long-term neurotoxicity from heavy ion irradiation AN - 21213711; 11177686 AB - Positron emission tomography (PET) permits imaging of the regional biodistribution and pharmacokinetics of compounds labeled with short-lived positron-emitting isotopes. It has enabled evaluation of neurochemical systems in the living human brain, including effects of toxic substances. MicroPET devices allos studies of the rat brain with a spatial resolution of ~2 mm. This is much poorer resolution than obtained using ex vivo autoradiography. However, animals need not be euthanized before imaging, so repeat studies are possible. This in principle allows the effects of toxic insults to be followed over the lifetime of an individual animal. We used microPET to evaluate brain metabolic effects of irradiation with high-energy heavy ions (HZE radiation), a component of the space radiation environment, on regional glucose metabolism. A significant fraction of neurons would be traversed by these densely ionizing particles during a Mars mission, and there is a need to estimate human neurological risks of prolonged voyages beyond the geomagnetosphere. Rats were irradiated withFe (600 MeV/n) ions at doses up to 240 cGy. At 9 months post-irradiation we did not detect alterations in regional accumulation of the glucose analog [F]2-deoxy-2-fluoro-D-glucose. This may indicate that damage to the brain from HZE particles is less severe than feared. However, because radiation-induced alterations in some behaviors have been documented, it may reflect insensitivity of baseline cerebral glucose metabolism to HZE radiation. These studies will facilitate design of future studies of chronic, long-term exposure to both therapeutic and abused drugs using microPET. JF - AAPS Journal AU - Rice, Onarae AU - Saintvictor, Sandra AU - Michaelides, Michael AU - Thanos, Panayotis AU - Gatley, Samuel John AD - Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY, s.gatley@neu.edu Y1 - 2006 PY - 2006 DA - 2006 SP - E508 EP - E514 PB - American Association of Pharmaceutical Scientists VL - 8 IS - 3 SN - 1550-7416, 1550-7416 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Ions KW - Isotopes KW - Neuroimaging KW - Brain injury KW - Brain KW - spatial discrimination KW - Glucose metabolism KW - Post-irradiation KW - Drug abuse KW - Autoradiography KW - Pharmacokinetics KW - Heavy ion radiation KW - Neurons KW - Neurotoxicity KW - Positron emission tomography KW - X 24390:Radioactive Materials KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21213711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AAPS+Journal&rft.atitle=MicroPET+investigation+of+chronic+long-term+neurotoxicity+from+heavy+ion+irradiation&rft.au=Rice%2C+Onarae%3BSaintvictor%2C+Sandra%3BMichaelides%2C+Michael%3BThanos%2C+Panayotis%3BGatley%2C+Samuel+John&rft.aulast=Rice&rft.aufirst=Onarae&rft.date=2006-01-01&rft.volume=8&rft.issue=3&rft.spage=E508&rft.isbn=&rft.btitle=&rft.title=AAPS+Journal&rft.issn=15507416&rft_id=info:doi/10.1208%2Faapsj080360 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ions; Neuroimaging; Isotopes; Brain injury; Brain; spatial discrimination; Glucose metabolism; Autoradiography; Drug abuse; Post-irradiation; Pharmacokinetics; Heavy ion radiation; Neurons; Neurotoxicity; Positron emission tomography DO - http://dx.doi.org/10.1208/aapsj080360 ER - TY - JOUR T1 - Attribution of modeled atmospheric sulfate and SO sub(2) in the Northern Hemisphere for June-July 1997 AN - 20741294; 7260455 AB - Anthropogenic sulfate aerosol is a major contributor to shortwave radiative forcing of climate change by direct light scattering and by perturbing cloud properties and to local concentrations of atmospheric particulate matter. Here we analyze results from previously published calculations with an Eulerian transport model for atmospheric sulfur species in the Northern Hemisphere in June-July, 1997 to quantify the absolute and relative contributions of specific source regions (North America, Europe, and Asia) and SO sub(2)-to-sulfate conversion mechanisms (gas-phase, aqueous-phase and primary sulfate) to sulfate and SO sub(2) column burdens as a function of location and time. Although material emitted within a given region dominates the sulfate and SO sub(2) column burden in that region, examination of time series at specific locations shows that material imported from outside can make a substantial and occasionally dominant contribution. Frequently the major fraction of these exogenous contributions to the sulfate column burden was present aloft, thus minimally impacting air quality at the surface, but contributing substantially to the burden and, by implication, to radiative forcing and diminution of surface irradiance. Although the dominant sulfate formation pathway in the domain as a whole is aqueous-phase reaction in clouds (62%), in regions with minimum opportunity for aqueous-phase reaction gas-phase oxidation is dominant, albeit with considerable temporal variability depending on meteorological conditions. These calculations highlight the importance of transoceanic transport of sulfate, especially at the western margins of continents under the influence of predominantly westerly transport winds. JF - Atmospheric Chemistry and Physics AU - Benkovitz, C M AU - Schwartz, SE AU - Jensen, M P AU - Miller, MA AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA Y1 - 2006 PY - 2006 DA - 2006 SP - 4723 EP - 4738 PB - European Geophysical Society, Max-Planck-Str. 13 37191 Katlenburg-Lindau Germany, [mailto:egs@copernicus.org], [URL:http://www.copernicus.org/] VL - 6 IS - 12 SN - 1680-7316, 1680-7316 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Sulfates KW - Sulfur KW - Atmospheric pollution models KW - Sulfur in atmosphere KW - Climatic changes KW - Climate change KW - Westerlies KW - Light scattering KW - Europe KW - Air quality KW - Time series analysis KW - Sulfur dioxide KW - Radiative forcing KW - Cloud properties KW - Asia KW - Meteorological conditions KW - North America KW - Aerosols KW - Atmospheric pollution KW - Climate models KW - time series analysis KW - Sulfate formation KW - Sulfate aerosols KW - Clouds KW - Atmospheric chemistry KW - Oxidation KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20741294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Chemistry+and+Physics&rft.atitle=Attribution+of+modeled+atmospheric+sulfate+and+SO+sub%282%29+in+the+Northern+Hemisphere+for+June-July+1997&rft.au=Benkovitz%2C+C+M%3BSchwartz%2C+SE%3BJensen%2C+M+P%3BMiller%2C+MA&rft.aulast=Benkovitz&rft.aufirst=C&rft.date=2006-01-01&rft.volume=6&rft.issue=12&rft.spage=4723&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Chemistry+and+Physics&rft.issn=16807316&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution models; Climate models; Atmospheric pollution; Sulfur in atmosphere; Climate change; Light scattering; Westerlies; Sulfate formation; Air quality; Sulfate aerosols; Time series analysis; Clouds; Radiative forcing; Oxidation; Atmospheric chemistry; Cloud properties; Meteorological conditions; Sulfur; Sulfates; Aerosols; Sulfur dioxide; time series analysis; Climatic changes; North America; Europe; Asia ER - TY - JOUR T1 - Comment on "size distribution of sea-salt emissions as a function of relative humidity" AN - 19573983; 6929801 AB - Tropospheric NO sub(2) column densities over China simulated with a regional model using different emission inventory input are compared with Global Ozone Monitoring Experiment (GOME) satellite data. These emission inventories include (i) emission estimates for the year 1995 from the Emission Database for Global Atmospheric Research (EDGAR), (ii) regional emission inventory used in the Transport and Chemical Evolution over the Pacific (TRACE-P) program with emission estimates for the year 2000 and (iii) national emission inventory used in the Chinese Ozone Research Programme (CORP) with emission estimates for the year 1995. Model simulations were performed for a summertime period and the results under clear-sky conditions were selected for comparison with GOME data of the years 1996 and 2000. The model generally reproduces high tropospheric NO sub(2) column densities in polluted areas of China that have been observed by GOME. However, the model simulations do not agree with the GOME measurements in a quantitative sense for some regions. Region-to-region comparisons show that with all the emission inventories the model underestimates the tropospheric NO sub(2) column density in remote and rural areas of China. It is found that TRACE-P underestimates the tropospheric NO sub(2) column density in all the regions with respect to the GOME measurements (by more than 50%). CORP and EDGAR appear to behave well for the model simulations in the North of China (within 15% deviations), but poorer for the model simulations in other regions (within 30-80% deviations). Linear regressions were performed with the NO sub(2) column densities available from GOME, Y, and the model, X, of each grid cell in selected regions. For all the region of China, comparison statistics are Y=0.361xX+0.935 with r super(2)=0.360 and bias=-41% for EDGAR, Y=1.124xX+0.920 with r super(2)=0.472 and bias=-67% for TRACE-P, and Y=0.431xX+0.835 with r super(2)=0.509 and bias=-31% for CORP. JF - Atmospheric Environment AU - Lewis, Ernie R AU - Schwartz, Stephen E AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY 11973-5000, USA, Elewis@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 588 EP - 590 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 40 IS - 3 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Tropospheric NO sub(2) KW - Emission inventory KW - Regional model KW - Satellite data KW - Gome KW - China KW - Relative humidity KW - Pollution monitoring KW - Sea salt particle size distribution KW - Atmospheric pollution models KW - Nitrogen dioxide in troposphere KW - Humidity effects on aerosols KW - Remote sensing KW - Statistical analysis KW - Emission inventories KW - Project TRACE KW - Emissions KW - Emission measurements KW - Regression analysis KW - Ozone KW - Ozone research KW - Simulation KW - Troposphere KW - Humidity KW - Satellites KW - Global Ozone Monitoring Experiment (GOME) KW - Sea salt particles-atmospheric interaction KW - Numerical simulations KW - Regional-scale models KW - China, People's Rep. KW - Evolution KW - Rural areas KW - M2 551.571:Humidity (551.571) KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19573983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Comment+on+%22size+distribution+of+sea-salt+emissions+as+a+function+of+relative+humidity%22&rft.au=Lewis%2C+Ernie+R%3BSchwartz%2C+Stephen+E&rft.aulast=Lewis&rft.aufirst=Ernie&rft.date=2006-01-01&rft.volume=40&rft.issue=3&rft.spage=588&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2005.08.043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Relative humidity; Sea salt particle size distribution; Nitrogen dioxide in troposphere; Atmospheric pollution models; Humidity effects on aerosols; Ozone research; Statistical analysis; Global Ozone Monitoring Experiment (GOME); Satellite data; Sea salt particles-atmospheric interaction; Numerical simulations; Regional-scale models; Project TRACE; Regression analysis; Evolution; Rural areas; Pollution monitoring; Emission inventories; Remote sensing; Emission measurements; Emissions; Humidity; Troposphere; Simulation; Satellites; Ozone; China, People's Rep. DO - http://dx.doi.org/10.1016/j.atmosenv.2005.08.043 ER - TY - JOUR T1 - Identification of amino acid residues involved in substrate specificity of plant acyl-ACP thioesterases using a bioinformatics-guided approach AN - 19449688; 7248491 AB - The large amount of available sequence information for the plant acyl-ACP thioesterases (TEs) made it possible to use a bioinformatics-guided approach to identify amino acid residues involved in substrate specificity. The Conserved Property Difference Locator (CPDL) program allowed the identification of putative specificity-determining residues that differ between the FatA and FatB te classes. Six of the FatA residue differences identified by CPDL were incorporated into the FatB-like parent via site-directed mutagenesis and the effect of each on te activity was determined. Variants were expressed in E. coli strain K27 that allows determination of enzyme activity by GCMS analysis of fatty acids released into the medium. Results Substitutions at four of the positions (74, 86, 141, and 174) changed substrate specificity to varying degrees while changes at the remaining two positions, 110 and 221, essentially inactivated the thioesterase. The effects of substitutions at positions 74, 141, and 174 (3-MUT) or 74, 86, 141, 174 (4-MUT) were not additive with respect to specificity. Conclusion Four of six putative specificity determining positions in plant TEs, identified with the use of CPDL, were validated experimentally; a novel colorimetric screen that discriminates between active and inactive TEs is also presented. JF - BMC Plant Biology AU - Mayer, Kimberly M AU - Shanklin, John AD - Brookhaven National Laboratory, Department of Biology, Upton, NY 11973 USA, mayerk@uncw.edu Y1 - 2006 PY - 2006 DA - 2006 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 1 KW - Site-directed mutagenesis KW - Amino acids KW - thioesterase KW - Escherichia coli KW - Fatty acids KW - Substrate specificity KW - Colorimetry KW - Enzymes KW - Amino acid sequence KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19449688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Plant+Biology&rft.atitle=Identification+of+amino+acid+residues+involved+in+substrate+specificity+of+plant+acyl-ACP+thioesterases+using+a+bioinformatics-guided+approach&rft.au=Mayer%2C+Kimberly+M%3BShanklin%2C+John&rft.aulast=Mayer&rft.aufirst=Kimberly&rft.date=2006-01-01&rft.volume=6&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Plant+Biology&rft.issn=1471-2229&rft_id=info:doi/10.1186%2F1471-2229-7-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Amino acids; thioesterase; Fatty acids; Enzymes; Colorimetry; Substrate specificity; Amino acid sequence; Escherichia coli DO - http://dx.doi.org/10.1186/1471-2229-7-1 ER - TY - JOUR T1 - Crystal structure of a putative HTH-type transcriptional regulator yxaF from Bacillus subtilis AN - 17170738; 6838764 JF - Proteins: Structure, Function & Bioinformatics AU - Seetharaman, Jayaraman AU - Kumaran, Desigan AU - Bonanno, Jeffrey B AU - Burley, Stephen K AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2006 PY - 2006 DA - 2006 SP - 1087 EP - 1091 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 63 IS - 4 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology KW - Protein structure KW - Bacillus subtilis KW - Crystal structure KW - Transcription KW - Bioinformatics KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17170738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=Crystal+structure+of+a+putative+HTH-type+transcriptional+regulator+yxaF+from+Bacillus+subtilis&rft.au=Seetharaman%2C+Jayaraman%3BKumaran%2C+Desigan%3BBonanno%2C+Jeffrey+B%3BBurley%2C+Stephen+K%3BSwaminathan%2C+Subramanyam&rft.aulast=Seetharaman&rft.aufirst=Jayaraman&rft.date=2006-01-01&rft.volume=63&rft.issue=4&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Bacillus subtilis; Transcription; Protein structure; Bioinformatics; Crystal structure DO - http://dx.doi.org/10.1002/prot.20924 ER - TY - CPAPER T1 - Novel Radiolabeled Ligands Based on Adenoviral Sub-Unit Proteins for Molecular Imaging T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39816172; 4067555 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Srivastava, S C AU - Awasthi, V AU - Meinken, G AU - Springer, K AU - Freimuth, P Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Imaging techniques KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Novel+Radiolabeled+Ligands+Based+on+Adenoviral+Sub-Unit+Proteins+for+Molecular+Imaging&rft.au=Srivastava%2C+S+C%3BAwasthi%2C+V%3BMeinken%2C+G%3BSpringer%2C+K%3BFreimuth%2C+P&rft.aulast=Srivastava&rft.aufirst=S&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bone-Localizing Electron-Emitting Therapeutic Radiopharmaceuticals T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39807913; 4067390 DE: JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Srivastava, S C Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Bone-Localizing+Electron-Emitting+Therapeutic+Radiopharmaceuticals&rft.au=Srivastava%2C+S+C&rft.aulast=Srivastava&rft.aufirst=S&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon-to-Metal Hydrogen Atom Transfers in the Formation of Metal Hydrides T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806154; 4067386 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bullock, M AU - Zhang, J AU - Grills, D C AU - Huang, K AU - Fujita, E Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Hydrogen KW - Metals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Carbon-to-Metal+Hydrogen+Atom+Transfers+in+the+Formation+of+Metal+Hydrides&rft.au=Bullock%2C+M%3BZhang%2C+J%3BGrills%2C+D+C%3BHuang%2C+K%3BFujita%2C+E&rft.aulast=Bullock&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preparation of @@u88@Y from the Niobium Cladding of Proton Irradiated Gallium Target T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806094; 4067366 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Mausner, L AU - Kurczak, S AU - Meinken, G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Gallium KW - Niobium KW - Protons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Preparation+of+%40%40u88%40Y+from+the+Niobium+Cladding+of+Proton+Irradiated+Gallium+Target&rft.au=Mausner%2C+L%3BKurczak%2C+S%3BMeinken%2C+G&rft.aulast=Mausner&rft.aufirst=L&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Desulfurization Reactions on Metal Carbides and Phosphides: Complex Role of the Carbon and Phosphorus Sites T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39774261; 4062319 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Rodriguez, J A Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Phosphorus KW - Metals KW - Desulfurization KW - Carbon KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Desulfurization+Reactions+on+Metal+Carbides+and+Phosphides%3A+Complex+Role+of+the+Carbon+and+Phosphorus+Sites&rft.au=Rodriguez%2C+J+A&rft.aulast=Rodriguez&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical Imaging of Biological Tissues Using a Combination of Synchrotron-Based Infrared and X-Ray Microscopy T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39764747; 4065734 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Miller, L AU - Smith, R AU - Wang, A AU - Lanzirotti, A AU - Warren, J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Microscopy KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chemical+Imaging+of+Biological+Tissues+Using+a+Combination+of+Synchrotron-Based+Infrared+and+X-Ray+Microscopy&rft.au=Miller%2C+L%3BSmith%2C+R%3BWang%2C+A%3BLanzirotti%2C+A%3BWarren%2C+J&rft.aulast=Miller&rft.aufirst=L&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photochemical Properties of Functionalized Polypyridylruthenium Complexes with a NAD+/NADH Model Ligand T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39760950; 4067145 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Fujita, E AU - Koizumi, T AU - Tanaka, K Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Photochemicals KW - Models KW - NADH KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Photochemical+Properties+of+Functionalized+Polypyridylruthenium+Complexes+with+a+NAD%2B%2FNADH+Model+Ligand&rft.au=Fujita%2C+E%3BKoizumi%2C+T%3BTanaka%2C+K&rft.aulast=Fujita&rft.aufirst=E&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Horizontal gene transfer to endogenous endophytic bacteria from poplar improves phytoremediation of toluene. AN - 68876308; 16332840 AB - Poplar, a plant species frequently used for phytoremediation of groundwater contaminated with organic solvents, was inoculated with the endophyte Burkholderia cepacia VM1468. This strain, whose natural host is yellow lupine, contains the pTOM-Bu61 plasmid coding for constitutively expressed toluene degradation. Noninoculated plants or plants inoculated with the soil bacterium B. cepacia Bu61(pTOM-Bu61) were used as controls. Inoculation of poplar had a positive effect on plant growth in the presence of toluene and reduced the amount of toluene released via evapotranspiration. These effects were more dramatic for VM1468, the endophytic strain, than for Bu61. Remarkably, none of the strains became established at detectable levels in the endophytic community, but there was horizontal gene transfer of pTOM-Bu61 to different members of the endogenous endophytic community, both in the presence and in the absence of toluene. This work is the first report of in planta horizontal gene transfer among plant-associated endophytic bacteria and demonstrates that such transfer could be used to change natural endophytic microbial communities in order to improve the remediation of environmental insults. JF - Applied and environmental microbiology AU - Taghavi, Safiyh AU - Barac, Tanja AU - Greenberg, Bill AU - Borremans, Brigitte AU - Vangronsveld, Jaco AU - van der Lelie, Daniel AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, NY 11973-5000. vdlelied@bnl.gov. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 8500 EP - 8505 VL - 71 IS - 12 SN - 0099-2240, 0099-2240 KW - DNA Primers KW - 0 KW - Toluene KW - 3FPU23BG52 KW - Index Medicus KW - Soil Microbiology KW - Polymerase Chain Reaction KW - Plant Stems -- microbiology KW - Plant Roots -- microbiology KW - Plant Leaves -- microbiology KW - Burkholderia cepacia -- metabolism KW - Burkholderia cepacia -- genetics KW - Toluene -- pharmacokinetics KW - Gene Transfer, Horizontal KW - Biodegradation, Environmental KW - Populus -- growth & development KW - Populus -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68876308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Horizontal+gene+transfer+to+endogenous+endophytic+bacteria+from+poplar+improves+phytoremediation+of+toluene.&rft.au=Taghavi%2C+Safiyh%3BBarac%2C+Tanja%3BGreenberg%2C+Bill%3BBorremans%2C+Brigitte%3BVangronsveld%2C+Jaco%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Taghavi&rft.aufirst=Safiyh&rft.date=2005-12-01&rft.volume=71&rft.issue=12&rft.spage=8500&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-07 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Environ Microbiol. 2000 Jun;2(3):319-23 [11200433] Appl Environ Microbiol. 2001 Feb;67(2):1015-9 [11157282] Environ Sci Technol. 2001 Nov 1;35(21):446A-452A [11718366] Microbiology. 2002 Feb;148(Pt 2):341-3 [11832496] Environ Microbiol. 2002 Dec;4(12):799-808 [12534463] Nat Biotechnol. 2004 May;22(5):583-8 [15077119] Trends Biotechnol. 2005 Jan;23(1):6-8; discussion 8-9 [15629849] Appl Environ Microbiol. 1992 Dec;58(12):3977-83 [1282314] Microbiol Rev. 1995 Mar;59(1):143-69 [7535888] Appl Environ Microbiol. 1995 Apr;61(4):1352-6 [7538275] Appl Environ Microbiol. 1998 Jun;64(6):2096-104 [9603820] Environ Microbiol. 2004 Dec;6(12):1244-51 [15560822] Adv Appl Microbiol. 2004;56:291-312 [15566983] J Bacteriol. 1985 Apr;162(1):328-34 [3884593] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Effect of water on compressibility of San Carlos Olivine and its implications AN - 50458382; 2009-073500 JF - Eos, Transactions, American Geophysical Union AU - Chen, J AU - Liu, H AU - Yu, T AU - Hu, J AU - Anonymous Y1 - 2005/12// PY - 2005 DA - December 2005 SP - Abstract MR41A EP - 0897 PB - American Geophysical Union, Washington, DC VL - 86 IS - 52, SUPPL. SN - 0096-3941, 0096-3941 KW - water KW - silicates KW - upper mantle KW - experimental studies KW - mantle KW - olivine group KW - elastic constants KW - bulk modulus KW - San Carlos Olivine KW - nesosilicates KW - physical properties KW - wadsleyite KW - orthosilicates KW - equations of state KW - anvil cells KW - P-T conditions KW - compressibility KW - 17B:Geophysics of minerals and rocks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50458382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Effect+of+water+on+compressibility+of+San+Carlos+Olivine+and+its+implications&rft.au=Chen%2C+J%3BLiu%2C+H%3BYu%2C+T%3BHu%2C+J%3BAnonymous&rft.aulast=Chen&rft.aufirst=J&rft.date=2005-12-01&rft.volume=86&rft.issue=52%2C+SUPPL.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2005 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; bulk modulus; compressibility; elastic constants; equations of state; experimental studies; mantle; nesosilicates; olivine group; orthosilicates; P-T conditions; physical properties; San Carlos Olivine; silicates; upper mantle; wadsleyite; water ER - TY - JOUR T1 - Flow banding in rhyolites; a manifestation of water concentration heterogeneity in the melt? AN - 50429743; 2009-043300 JF - Eos, Transactions, American Geophysical Union AU - Seaman, S J AU - Dyar, D AU - Marinkovic, N AU - Anonymous Y1 - 2005/12// PY - 2005 DA - December 2005 SP - Abstract V41I EP - 05 PB - American Geophysical Union, Washington, DC VL - 86 IS - 52, SUPPL. SN - 0096-3941, 0096-3941 KW - water KW - United States KW - silicates KW - concentration KW - rhyolites KW - volcanic rocks KW - lava flows KW - gaseous phase KW - igneous rocks KW - Atascosa Mountains KW - southern Arizona KW - melts KW - infrared spectra KW - FTIR spectra KW - mineral composition KW - magmas KW - spherulites KW - Arizona KW - crystallization KW - framework silicates KW - spectra KW - heterogeneity KW - feldspar group KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50429743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Melanoma&rft.atitle=Data+Supporting+an+Important+Role+for+Wavelengths+Greater+than+UVB+in+Inducing+Melanomas&rft.au=Setlow%2C+R&rft.aulast=Setlow&rft.aufirst=R&rft.date=2005-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Melanoma&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2005 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - Arizona; Atascosa Mountains; concentration; crystallization; feldspar group; framework silicates; FTIR spectra; gaseous phase; heterogeneity; igneous rocks; infrared spectra; lava flows; magmas; melts; mineral composition; rhyolites; silicates; southern Arizona; spectra; spherulites; United States; volcanic rocks; water ER - TY - CPAPER T1 - Effects of Anesthesia on NMDA Receptor Open - Channel Density in Amyloid - b Overproducing and Wild - Type Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39998712; 4133950 JF - 35th Annual Meeting of the Society for Neuroscience AU - Biegon, A AU - Pareto, D AU - Guol, J AU - Kofke, W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Mice KW - Anesthesia KW - Glutamic acid receptors KW - B-Amyloid KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Anesthesia+on+NMDA+Receptor+Open+-+Channel+Density+in+Amyloid+-+b+Overproducing+and+Wild+-+Type+Mice&rft.au=Biegon%2C+A%3BPareto%2C+D%3BGuol%2C+J%3BKofke%2C+W&rft.aulast=Biegon&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Food Restriction in Female Rats Increased Conditioned Place Preference for Food Compared to Cocaine T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39992302; 4121742 JF - 35th Annual Meeting of the Society for Neuroscience AU - Barbarich-Marsteller, N C AU - Marsteller, D A AU - Fowler, J S AU - Dewey, S L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Food preferences KW - Cocaine KW - Food availability KW - Place preferences KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39992302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Chronic+Food+Restriction+in+Female+Rats+Increased+Conditioned+Place+Preference+for+Food+Compared+to+Cocaine&rft.au=Barbarich-Marsteller%2C+N+C%3BMarsteller%2C+D+A%3BFowler%2C+J+S%3BDewey%2C+S+L&rft.aulast=Barbarich-Marsteller&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Morris Water Maze Data from HVS Running Systems Using Microsoft Excel and Sigma Stat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39983507; 4130335 JF - 35th Annual Meeting of the Society for Neuroscience AU - Flavin, N J AU - Neill, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Running KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Analysis+of+Morris+Water+Maze+Data+from+HVS+Running+Systems+Using+Microsoft+Excel+and+Sigma+Stat&rft.au=Flavin%2C+N+J%3BNeill%2C+J+C&rft.aulast=Flavin&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optical Brain Monitoring of Cerebrovascular and Intracellular Calcium Effects Induced by Acute Cocaine Exposure in the Living Rat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39980307; 4133704 JF - 35th Annual Meeting of the Society for Neuroscience AU - Du, C. AU - Thanos, P K AU - Yu, M. AU - Rivera, S AU - Benveniste, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium (intracellular) KW - Brain KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39980307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Optical+Brain+Monitoring+of+Cerebrovascular+and+Intracellular+Calcium+Effects+Induced+by+Acute+Cocaine+Exposure+in+the+Living+Rat&rft.au=Du%2C+C.%3BThanos%2C+P+K%3BYu%2C+M.%3BRivera%2C+S%3BBenveniste%2C+H&rft.aulast=Du&rft.aufirst=C.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Changes in NMDA Receptor Activation Following Intracranial Surgery: [11C]CNS5161 microPET Studies T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39925460; 4133953 JF - 35th Annual Meeting of the Society for Neuroscience AU - Schiffer, W K AU - Alexoff, D AU - Dewey, S L AU - Ding, Y AU - Gibbs, A R AU - Lin, K AU - Pareto, D AU - Wu, H. AU - Biegon, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Surgery KW - Glutamic acid receptors KW - Receptor mechanisms KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamic+Changes+in+NMDA+Receptor+Activation+Following+Intracranial+Surgery%3A+%5B11C%5DCNS5161+microPET+Studies&rft.au=Schiffer%2C+W+K%3BAlexoff%2C+D%3BDewey%2C+S+L%3BDing%2C+Y%3BGibbs%2C+A+R%3BLin%2C+K%3BPareto%2C+D%3BWu%2C+H.%3BBiegon%2C+A&rft.aulast=Schiffer&rft.aufirst=W&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute Administration of Cocaine in DAT Mice: Effect on Cerebral Glucose Metabolism Using mPET T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923210; 4132012 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rivera, S N AU - Caron, M G AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glucose metabolism KW - Mice KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Acute+Administration+of+Cocaine+in+DAT+Mice%3A+Effect+on+Cerebral+Glucose+Metabolism+Using+mPET&rft.au=Rivera%2C+S+N%3BCaron%2C+M+G%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Rivera&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Monetary Reward on Event - Related Potentials in Cocaine Addiction T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39895977; 4128110 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cottone, L A AU - Maloney, T AU - Delosh, D AU - Leskovjan, A AU - Alia-Klein, N AU - Telang, F AU - Squires, N K AU - Fowler, J S AU - Volkow, N D AU - Goldstein, R Z Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Economics KW - Addiction KW - Reinforcement KW - Cocaine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39895977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effect+of+Monetary+Reward+on+Event+-+Related+Potentials+in+Cocaine+Addiction&rft.au=Cottone%2C+L+A%3BMaloney%2C+T%3BDelosh%2C+D%3BLeskovjan%2C+A%3BAlia-Klein%2C+N%3BTelang%2C+F%3BSquires%2C+N+K%3BFowler%2C+J+S%3BVolkow%2C+N+D%3BGoldstein%2C+R+Z&rft.aulast=Cottone&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracranial Surgery Results in Long Term Changes in NMDA and Peripheral Benzodiazepine Receptor Density in Rat Brain T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39890143; 4133952 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tsabari, R AU - Schiffer, W K AU - Biegon, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Surgery KW - Brain KW - Benzodiazepine receptors KW - Receptor density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39890143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Fabric+and+uranyl+retention+of+neomorphosed+aragonite+botryoids%3B+constraints+on+the+diagenetic+process&rft.au=Rasbury%2C+E+Troy%3BWard%2C+W+Bruce%3BNorthrup%2C+Paul+A%3BAnonymous&rft.aulast=Rasbury&rft.aufirst=E&rft.date=2005-10-01&rft.volume=37&rft.issue=7&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Functional Neural Pathways in the Rat Brain Using [18F]Fluorodeoxyglucose and Intracranial Electrical Stimulation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39884401; 4126951 JF - 35th Annual Meeting of the Society for Neuroscience AU - Dhawan, J AU - Kandrapa, S AU - Gifford, A N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain mapping KW - Electrical stimuli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mapping+Functional+Neural+Pathways+in+the+Rat+Brain+Using+%5B18F%5DFluorodeoxyglucose+and+Intracranial+Electrical+Stimulation&rft.au=Dhawan%2C+J%3BKandrapa%2C+S%3BGifford%2C+A+N&rft.aulast=Dhawan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age - Related Changes of Striatal Dopamine D@@d2@ Receptor (D@@d2@R) Binding in Obese (fa/fa) and Lean (Le) Zucker Rats Revealed by Positron Emission Tomography (PET) T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883885; 4126828 JF - 35th Annual Meeting of the Society for Neuroscience AU - Michaelides, M E AU - Thanos, P K AU - Rivera, S N AU - Wang, G AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Positron emission tomography KW - Neostriatum KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Age+-+Related+Changes+of+Striatal+Dopamine+D%40%40d2%40+Receptor+%28D%40%40d2%40R%29+Binding+in+Obese+%28fa%2Ffa%29+and+Lean+%28Le%29+Zucker+Rats+Revealed+by+Positron+Emission+Tomography+%28PET%29&rft.au=Michaelides%2C+M+E%3BThanos%2C+P+K%3BRivera%2C+S+N%3BWang%2C+G%3BVolkow%2C+N+D&rft.aulast=Michaelides&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measure of Induced Changes in Neurotransmitter and Glucose Metabolism During Chronic Citalopram Infusion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39874733; 4126758 JF - 35th Annual Meeting of the Society for Neuroscience AU - Marsteller, D A AU - Patel, V D AU - Barbarich-Marsteller, N C AU - Dewey, S L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glucose metabolism KW - Neurotransmitters KW - Citalopram KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measure+of+Induced+Changes+in+Neurotransmitter+and+Glucose+Metabolism+During+Chronic+Citalopram+Infusion&rft.au=Marsteller%2C+D+A%3BPatel%2C+V+D%3BBarbarich-Marsteller%2C+N+C%3BDewey%2C+S+L&rft.aulast=Marsteller&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time - Course Changes of Dopamine D@@d2@ and CB1 Cannabinoid Receptors During Cocaine Self - Administration T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872810; 4128482 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Soria, L AU - Michaelides, M E AU - Piyis, Y K AU - Pappas, G P AU - Maldonado, R AU - Valverde, O AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cocaine KW - Cannabinoid CB1 receptors KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Time+-+Course+Changes+of+Dopamine+D%40%40d2%40+and+CB1+Cannabinoid+Receptors+During+Cocaine+Self+-+Administration&rft.au=Thanos%2C+P+K%3BSoria%2C+L%3BMichaelides%2C+M+E%3BPiyis%2C+Y+K%3BPappas%2C+G+P%3BMaldonado%2C+R%3BValverde%2C+O%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long - term Effects of Whole - brain Irradiation on Auditory Discrimination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39870042; 4129068 JF - 35th Annual Meeting of the Society for Neuroscience AU - Aubele, T M AU - Kristiansen, R AU - Murphy, M AU - Rice, O AU - Gately, S J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Irradiation KW - Radiation KW - Auditory discrimination KW - Abiotic factors KW - Light effects KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Long+-+term+Effects+of+Whole+-+brain+Irradiation+on+Auditory+Discrimination&rft.au=Aubele%2C+T+M%3BKristiansen%2C+R%3BMurphy%2C+M%3BRice%2C+O%3BGately%2C+S+J&rft.aulast=Aubele&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Aging and Seizures on Auditory Discrimination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39860955; 4119073 JF - 35th Annual Meeting of the Society for Neuroscience AU - Neill, J C AU - Holmes, G L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Aging KW - Auditory discrimination KW - Seizures KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Aging+and+Seizures+on+Auditory+Discrimination&rft.au=Neill%2C+J+C%3BHolmes%2C+G+L&rft.aulast=Neill&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Methylphenidate and Amphetamineon Locomotor Activity and Conditioned Place Preference in Dopamine D@@d4R@ Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39827089; 4123479 JF - 35th Annual Meeting of the Society for Neuroscience AU - Vavilis, G N AU - Grandy, D AU - Suchland, K AU - Rubinstein, M AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Methylphenidate KW - Dopamine D4 receptors KW - Locomotor activity KW - Place preferences KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Methylphenidate+and+Amphetamineon+Locomotor+Activity+and+Conditioned+Place+Preference+in+Dopamine+D%40%40d4R%40+Mice&rft.au=Vavilis%2C+G+N%3BGrandy%2C+D%3BSuchland%2C+K%3BRubinstein%2C+M%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Vavilis&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Cognitive Functioning and Recent Cocaine Use: Evidence from Neuropsychological Testing and Urine Toxicology T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39817688; 4126795 JF - 35th Annual Meeting of the Society for Neuroscience AU - Goldstein, R Z AU - Delosh, D AU - Cottone, L A AU - Leskovjan, A AU - Alia-Klein, N AU - Fowler, J S AU - Wang, G AU - Telang, F AU - Maloney, T AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Urine KW - Cocaine KW - Cognitive ability KW - Toxicology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39817688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Relationship+between+Cognitive+Functioning+and+Recent+Cocaine+Use%3A+Evidence+from+Neuropsychological+Testing+and+Urine+Toxicology&rft.au=Goldstein%2C+R+Z%3BDelosh%2C+D%3BCottone%2C+L+A%3BLeskovjan%2C+A%3BAlia-Klein%2C+N%3BFowler%2C+J+S%3BWang%2C+G%3BTelang%2C+F%3BMaloney%2C+T%3BVolkow%2C+N+D&rft.aulast=Goldstein&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Acute Methylphenidate on Condition Position Responding ( Visual Position Discrimination ) in SHR and WKY Rats T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39797679; 4131934 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pena, L A AU - Reiszel, C AU - Drepanis, A D AU - Volkow, N D AU - Thanos, P K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Methylphenidate KW - Visual discrimination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39797679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Acute+Methylphenidate+on+Condition+Position+Responding+%28+Visual+Position+Discrimination+%29+in+SHR+and+WKY+Rats&rft.au=Pena%2C+L+A%3BReiszel%2C+C%3BDrepanis%2C+A+D%3BVolkow%2C+N+D%3BThanos%2C+P+K&rft.aulast=Pena&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mechanisms of uranium mineralization by the yeast Saccharomyces cerevisiae AN - 51602645; 2006-030861 AB - We determined the association of uranium in yeast cells S. cerevisiae grown in medium containing high (1 g.L (super -1) ) or low (0.2 g.L (super -1) ) concentrations of phosphate after exposure for 96 h to a 4 X 10 (super -4) mol.L (super -1) U(VI) solution at pH 3.2 or 4.7. The analysis was made using a field emission scanning electron microscope equipped with energy dispersive spectroscopy (FESEM-EDS), transmission electron microscopy (TEM), and visible diffuse reflectance spectrometry. Cells grown in the high-phosphate medium rapidly accumulated U(VI) from solution at pH 3.2 over the first 24 h, followed by a slow uptake until 96 h, whereas in cells grown in low-phosphate medium, U(VI) accumulation reached a steady state within 24 h. FESEM-EDS analyses revealed the formation of a U(VI)-bearing precipitate on the yeast cells grown in high-phosphate medium after only 48 h exposure; no precipitate was detected on cells grown in low-phosphate medium up to 96 h. These results suggest that sorption onto the cell surfaces was the dominant process initially. Analysis of the U(VI)-bearing precipitates by all three methods demonstrated the presence of H-autunite, HUO (sub 2) PO (sub 4) .4H (sub 2) O. Thermodynamic calculations suggest that the chemical compositions of the solutions containing yeast grown in high-phosphate medium were undersaturated with respect to H-autunite, but were supersaturated with ten times more U(VI) and P than were actually observed. Apparently, the sorbed U(VI) on the cell surfaces reacts with P released from the yeast to form H-autunite by local saturation. The U(VI) uptake by yeast cells grown in high phosphate medium at pH 4.7, along with the thermodynamic calculation, indicated that more H-autunite is precipitated in neutral pH solution than in acid solution. Thus, U(VI)-phosphate mineralization on the cells of microorganisms should be taken into account for predicting U(VI) mobility in the environment. JF - Geochimica et Cosmochimica Acta AU - Ohnuki, Toshihiko AU - Ozaki, T AU - Yoshida, T AU - Sakamoto, F AU - Kozai, N AU - Wakai, E AU - Francis, A J AU - Iefuji, H Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 5307 EP - 5316 PB - Pergamon, Oxford VL - 69 IS - 22 SN - 0016-7037, 0016-7037 KW - mineral deposits, genesis KW - autunite KW - mass spectra KW - aqueous solutions KW - metallogeny KW - mineralization KW - acidic composition KW - spectra KW - thermodynamic properties KW - geochemistry KW - Bacillus KW - pH KW - phosphates KW - TEM data KW - Saccharomyces cerevisiae KW - ICP mass spectra KW - uranium ores KW - biogenic processes KW - precipitation KW - bacteria KW - metal ores KW - mobilization KW - SEM data KW - microorganisms KW - 02C:Geochemistry of rocks, soils, and sediments KW - 27A:Economic geology, geology of ore deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51602645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Mechanisms+of+uranium+mineralization+by+the+yeast+Saccharomyces+cerevisiae&rft.au=Ohnuki%2C+Toshihiko%3BOzaki%2C+T%3BYoshida%2C+T%3BSakamoto%2C+F%3BKozai%2C+N%3BWakai%2C+E%3BFrancis%2C+A+J%3BIefuji%2C+H&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2005-11-01&rft.volume=69&rft.issue=22&rft.spage=5307&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2005.06.023 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2006-01-01 N1 - Number of references - 39 N1 - Document feature - illus. incl. 1 plate N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - acidic composition; aqueous solutions; autunite; Bacillus; bacteria; biogenic processes; geochemistry; ICP mass spectra; mass spectra; metal ores; metallogeny; microorganisms; mineral deposits, genesis; mineralization; mobilization; pH; phosphates; precipitation; Saccharomyces cerevisiae; SEM data; spectra; TEM data; thermodynamic properties; uranium ores DO - http://dx.doi.org/10.1016/j.gca.2005.06.023 ER - TY - JOUR T1 - Magnetic field shift due to mechanical vibration in functional magnetic resonance imaging AN - 20859656; 8367947 AB - Mechanical vibrations of the gradient coil system during readout in echo-planar imaging (EPI) can increase the temperature of the gradient system and alter the magnetic field distribution during functional magnetic resonance imaging (fMRI). This effect is enhanced by resonant modes of vibrations and results in apparent motion along the phase encoding direction in fMRI studies. The magnetic field drift was quantified during EPI by monitoring the resonance frequency interleaved with the EPI acquisition, and a novel method is proposed to correct the apparent motion. The knowledge on the frequency drift over time was used to correct the phase of the k-space EPI dataset. Since the resonance frequency changes very slowly over time, two measurements of the resonance frequency, immediately before and after the EPI acquisition, are sufficient to remove the field drift effects from fMRI time series. The frequency drift correction method was tested in vivo and compared to the standard image realignment method. The proposed method efficiently corrects spurious motion due to magnetic field drifts during fMRI. JF - Magnetic Resonance in Medicine AU - Foerster, Bernd U AU - Tomasi, Dardo AU - Caparelli, Elisabeth C AD - Medical Department, Brookhaven National Laboratory, Upton, New York, USA, bfoerster@bnl.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1261 EP - 1267 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Vibrations KW - Magnetic fields KW - Drift KW - Functional magnetic resonance imaging KW - Magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Magnetic+field+shift+due+to+mechanical+vibration+in+functional+magnetic+resonance+imaging&rft.au=Foerster%2C+Bernd+U%3BTomasi%2C+Dardo%3BCaparelli%2C+Elisabeth+C&rft.aulast=Foerster&rft.aufirst=Bernd&rft.date=2005-11-01&rft.volume=54&rft.issue=5&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20695 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Drift; Magnetic fields; Vibrations; Temperature effects; Magnetic resonance imaging DO - http://dx.doi.org/10.1002/mrm.20695 ER - TY - JOUR T1 - Can Motion Artifacts be Completely Removed from fMRI-Activation Maps? AN - 20642166; 7724341 AB - Most functional magnetic resonance imaging (fMRI) studies are based on the detection of small timedependent signal variation induced by changes in blood oxygenation during brain activation. However, since this signal change is very small (typically 1-5%; even under optimal conditions and high magnetic field strengths), head motion as small as 1 mm translation or 1 degree rotation, can also produce spurious activation, if correlated with the stimulus paradigm. Several methods have been proposed to retrospectively (during image post-processing) or prospectively (in real time) correct for motion, however these techniques generally correct only for geometric rigid- body effects. Head motion can also change the magnetic field homogeneity, altering the effective relaxation rates of tissues (R2'), and producing timedependent geometrical distortions in fMRI studies. Unfortunately these non-linear motion-related artifacts become worse at high field strengths and cannot be corrected by standard image realignment methods; therefore, the range of motion is restricted for in vivo fMRI studies, especially at high field strengths. Real-time motion monitoring during fMRI can provide highly accurate information on whether subject motion during an fMRI scan was acceptable or excessive, and whether repeat scans with excessive motion are necessary. JF - Current Medical Imaging Reviews AU - Caparelli, Elisabeth DC AD - Brookhaven National Laboratory, Medical Dept., Bldg. 490, Upton, NY 11973, USA. Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 253 EP - 264 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 1 IS - 3 SN - 1573-4056, 1573-4056 KW - Biotechnology and Bioengineering Abstracts KW - fmri KW - brain movement KW - motion detector KW - motion artifacts KW - motion correction KW - spurious activation KW - Magnetic fields KW - Translation KW - Blood KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20642166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medical+Imaging+Reviews&rft.atitle=Can+Motion+Artifacts+be+Completely+Removed+from+fMRI-Activation+Maps%3F&rft.au=Caparelli%2C+Elisabeth+DC&rft.aulast=Caparelli&rft.aufirst=Elisabeth&rft.date=2005-11-01&rft.volume=1&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Current+Medical+Imaging+Reviews&rft.issn=15734056&rft_id=info:doi/10.2174%2F157340505774574727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain mapping; Blood; Translation; Magnetic fields; Neuroimaging; Functional magnetic resonance imaging DO - http://dx.doi.org/10.2174/157340505774574727 ER - TY - JOUR T1 - Translational Neuroimaging: Positron Emission Tomography Studies of Monoamine Oxidase AN - 17107384; 6737092 AB - Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs. JF - Molecular Imaging and Biology AU - Fowler, J S AU - Logan, J AU - Volkow, N D AU - Wang, G-J AD - Brookhaven National Laboratory, Upton, NY 11973, USA, fowler@bnl.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 377 EP - 387 VL - 7 IS - 6 SN - 1536-1632, 1536-1632 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Translation KW - Neuroimaging KW - L-deprenyl KW - Amine oxidase (flavin-containing) KW - Enzymes KW - Serotonin KW - amines KW - Dopamine KW - Norepinephrine KW - Positron emission tomography KW - Neurotransmitters KW - tyramine KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17107384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Imaging+and+Biology&rft.atitle=Translational+Neuroimaging%3A+Positron+Emission+Tomography+Studies+of+Monoamine+Oxidase&rft.au=Fowler%2C+J+S%3BLogan%2C+J%3BVolkow%2C+N+D%3BWang%2C+G-J&rft.aulast=Fowler&rft.aufirst=J&rft.date=2005-11-01&rft.volume=7&rft.issue=6&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Molecular+Imaging+and+Biology&rft.issn=15361632&rft_id=info:doi/10.1007%2Fs11307-005-0016-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Amine oxidase (flavin-containing); Positron emission tomography; Translation; Neuroimaging; tyramine; Norepinephrine; Serotonin; Neurotransmitters; Dopamine; L-deprenyl; amines; Enzymes DO - http://dx.doi.org/10.1007/s11307-005-0016-1 ER - TY - JOUR T1 - Catalysts for hydrogen evolution from the [NiFe] hydrogenase to the Ni2P(001) surface: the importance of ensemble effect. AN - 68701791; 16231942 AB - Density functional theory (DFT) was employed to investigate the behavior of a series of catalysts used in the hydrogen evolution reaction (HER, 2H(+) + 2e(-) --> H(2)). The kinetics of the HER was studied on the [NiFe] hydrogenase, the [Ni(PS3*)(CO)](1)(-) and [Ni(PNP)(2)](2+) complexes, and surfaces such as Ni(111), Pt(111), or Ni(2)P(001). Our results show that the [NiFe] hydrogenase exhibits the highest activity toward the HER, followed by [Ni(PNP)(2)](2+) > Ni(2)P > [Ni(PS3*)(CO)](1)(-) > Pt > Ni in a decreasing sequence. The slow kinetics of the HER on the surfaces is due to the fact that the metal hollow sites bond hydrogen too strongly to allow the facile removal of H(2). In fact, the strong H-Ni interaction on Ni(2)P(001) can lead to poisoning of the highly active sites of the surface, which enhances the rate of the HER and makes it comparable to that of the [NiFe] hydrogenase. In contrast, the promotional effect of H-poisoning on the HER on Pt and Ni surfaces is relatively small. Our calculations suggest that among all of the systems investigated, Ni(2)P should be the best practical catalyst for the HER, combining the high thermostability of the surfaces and high catalytic activity of the [NiFe] hydrogenase. The good behavior of Ni(2)P(001) toward the HER is found to be associated with an ensemble effect, where the number of active Ni sites is decreased due to presence of P, which leads to moderate bonding of the intermediates and products with the surface. In addition, the P sites are not simple spectators and directly participate in the HER. JF - Journal of the American Chemical Society AU - Liu, Ping AU - Rodriguez, José A AD - Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/10/26/ PY - 2005 DA - 2005 Oct 26 SP - 14871 EP - 14878 VL - 127 IS - 42 SN - 0002-7863, 0002-7863 KW - Organometallic Compounds KW - 0 KW - Nickel KW - 7OV03QG267 KW - Hydrogen KW - 7YNJ3PO35Z KW - nickel-iron hydrogenase KW - EC 1.12.- KW - Hydrogenase KW - EC 1.12.7.2 KW - Index Medicus KW - Kinetics KW - Models, Chemical KW - Surface Properties KW - Organometallic Compounds -- chemistry KW - Catalysis KW - Hydrogen -- chemistry KW - Nickel -- chemistry KW - Hydrogenase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68701791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Catalysts+for+hydrogen+evolution+from+the+%5BNiFe%5D+hydrogenase+to+the+Ni2P%28001%29+surface%3A+the+importance+of+ensemble+effect.&rft.au=Liu%2C+Ping%3BRodriguez%2C+Jos%C3%A9+A&rft.aulast=Liu&rft.aufirst=Ping&rft.date=2005-10-26&rft.volume=127&rft.issue=42&rft.spage=14871&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Selective Metal Binding to a Membrane-embedded Aspartate in the Escherichia coli Metal Transporter YiiP (FieF) AN - 17665736; 6503318 AB - The cation diffusion facilitators (CDF) are a ubiquitous family of metal transporters that play important roles in homeostasis of a wide range of divalent metal cations. Molecular identities of substrate-binding sites and their metal selectivity in the CDF family are thus far unknown. By using isothermal titration calorimetry and stopped-flow spectrofluorometry, we directly examined metal binding to a highly conserved aspartate in the Escherichia coli CDF transporter YiiP (FieF). A D157A mutation abolished a Cd super(2+)-binding site and impaired the corresponding Cd super(2+) transport. In contrast, substitution of Asp-157 with a cysteinyl coordination residue resulted in intact Cd super(2+) binding as well as full transport activity. A similar correlation was found for Zn super(2+) binding and transport, suggesting that Asp-157 is a metal coordination residue required for binding and transport of Cd super(2+) and Zn super(2+). The location of Asp-157 was mapped topologically to the hydrophobic core of transmembrane segment 5 (TM-5) where D157C was found partially accessible to thiol-specific labeling of maleimide polyethylene-oxide biotin. Binding of Zn super(2+) and Cd super(2+), but not Fe super(2+), Hg super(2+), Co super(2+), Ni super(2+), Mn super(2+), Ca super(2+), and Mg super(2+), protected D157C from maleimide polyethylene-oxide biotin labeling in a concentration-dependent manner. Furthermore, isothermal titration calorimetry analysis of YiiP sub(D157A) showed no detectable change in Fe super(2+) and Hg super(2+) calorimetric titrations, indicating that Asp-157 is not a coordination residue for Fe super(2+) and Hg super(2+) binding. Our results provided direct evidence for selective binding of Zn super(2+) and Cd super(2+) for to the highly conserved Asp-157 and defined its functional role in metal transport. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2005/10/07/ PY - 2005 DA - 2005 Oct 07 SP - 33716 EP - 33724 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 40 SN - 0021-9258, 0021-9258 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - G 07320:Bacterial genetics KW - J 02723:Photosynthesis, electron transport and related phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17665736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Selective+Metal+Binding+to+a+Membrane-embedded+Aspartate+in+the+Escherichia+coli+Metal+Transporter+YiiP+%28FieF%29&rft.au=Wei%2C+Yinan%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Elisabeth&rft.date=2005-11-01&rft.volume=1&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Current+Medical+Imaging+Reviews&rft.issn=15734056&rft_id=info:doi/10.2174%2F157340505774574727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Induction of anchorage-independent growth in primary human cells exposed to protons or HZE ions separately or in dual exposures. AN - 68634651; 16187755 AB - Travelers on space missions will be exposed to a complex radiation environment that includes protons and heavy charged particles. Since protons are present at much higher levels than are heavy ions, the most likely scenario for cellular radiation exposure will be proton exposure followed by a hit by a heavy ion. Although the effects of individual ion species on human cells are being investigated extensively, little is known about the effects of exposure to both radiation types. One useful measure of mammalian cell damage is induction of the ability to grow in a semi-solid agar medium highly inhibitory to the growth of normal human cells, termed neoplastic transformation. Using primary human cells, we evaluated induction of soft-agar growth and survival of cells exposed to protons only or to heavy charged particles (600 MeV/nucleon silicon) only as well as of cells exposed to protons followed after a 4-day interval by silicon ions. Both ions alone efficiently transformed the human cells to anchorage-independent growth. Initial experiments indicate that the dose responses for neoplastic transformation of cells exposed to protons and then after 4 days to silicon ions appear similar to that of cells exposed to silicon ions alone. JF - Radiation research AU - Sutherland, B M AU - Cuomo, N C AU - Bennett, P V AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 493 EP - 496 VL - 164 IS - 4 Pt 2 SN - 0033-7587, 0033-7587 KW - Protons KW - 0 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Cells, Cultured KW - Humans KW - Fibroblasts -- radiation effects KW - Dose-Response Relationship, Radiation KW - Protons -- adverse effects KW - Cell Proliferation -- radiation effects KW - Space Flight KW - Cosmic Radiation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68634651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Induction+of+anchorage-independent+growth+in+primary+human+cells+exposed+to+protons+or+HZE+ions+separately+or+in+dual+exposures.&rft.au=Sutherland%2C+B+M%3BCuomo%2C+N+C%3BBennett%2C+P+V&rft.aulast=Sutherland&rft.aufirst=B&rft.date=2005-10-01&rft.volume=164&rft.issue=4+Pt+2&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-10 N1 - Date created - 2005-09-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Effect of A-site cation radius on ordering of BX (sub 6) octahedra in (K,Na)MgF (sub 3) perovskite AN - 51642778; 2006-007997 AB - We present a structural model for (K,Na)MgF (sub 3) perovskite using results from high-resolution synchrotron X-ray powder diffraction and nuclear magnetic resonance (NMR) spectroscopy. (K,Na)MgF (sub 3) perovskite is found to transition from orthorhombic (Pbnm) to tetragonal (P4/mbm) to cubic (Pm[Formula: see text]m) as potassium concentration is increased. These phase transitions are not accompanied by a discontinuity in pseudo-cubic unit-cell volume and occur close to compositions (K (sub 0.37) Na (sub 0.63) )MgF (sub 3) and (K (sub 0.47) Na (sub 0.53) )MgF (sub 3) , respectively. (super 19) F NMR spectra indicate that the Na (super +) and K (super +) cations do not occupy the A cation site at random and end-member local environments are favored for all compositions. Based on results from both X-ray diffraction and NMR, we propose that diffuse diffraction is the result of strain between coexisting regions of different octahedra (MgF (sub 6) ) tilts brought about by the ionic radius mismatch of Na (super +) and K (super +) cations. We suggest A-site cations group with like cations as neighbors to reduce excess volume and total strain. JF - American Mineralogist AU - Martin, C David AU - Chaudhuri, Santanu AU - Grey, Clare P AU - Parise, John B Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1522 EP - 1533 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 10 SN - 0003-004X, 0003-004X KW - synchrotron radiation KW - X-ray diffraction data KW - perovskite KW - oxides KW - cations KW - crystal structure KW - spectra KW - powder method KW - synthetic materials KW - NMR spectra KW - order-disorder KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51642778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Effect+of+A-site+cation+radius+on+ordering+of+BX+%28sub+6%29+octahedra+in+%28K%2CNa%29MgF+%28sub+3%29+perovskite&rft.au=Martin%2C+C+David%3BChaudhuri%2C+Santanu%3BGrey%2C+Clare+P%3BParise%2C+John+B&rft.aulast=Martin&rft.aufirst=Bernd&rft.date=2005-11-01&rft.volume=54&rft.issue=5&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20695 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Abstract, copyright, Mineralogical Society of America | Reference includes data from GeoScienceWorld, Alexandria, VA, United States N1 - Date revised - 2006-01-01 N1 - Number of references - 72 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - cations; crystal structure; NMR spectra; order-disorder; oxides; perovskite; powder method; spectra; synchrotron radiation; synthetic materials; X-ray diffraction data DO - http://dx.doi.org/10.2138/am.2005.1693 ER - TY - JOUR T1 - Effects of in situ remediation on the speciation and bioavailability of zinc in a smelter contaminated soil AN - 51630916; 2006-017026 AB - We report results from an extensive study on the speciation of zinc (Zn) and its relation to the mobility and bioavailablity of this element in a smelter contaminated soil and an in situ remediated area of this soil 12 yr after the application of cyclonic ash and compost. Emphasis was placed on the role of neoformed precipitates in controlling Zn speciation, mobility and bioavailability under different environmental conditions. Twelve years after remediation, the pH of the treated and non-treated soil differed by only 0.5 pH unit. Using state-of-the-art electron and X-ray microscopies in combination with micro-focused extended X-ray absorption fine structure (mu -EXAFS) spectroscopy, no major differences in Zn speciation were found between samples of the treated and non-treated soil. In both soils, 30% to 50% of Zn was present in smelter related minerals (willemite, hemimorphite or gahnite), while 50% to 70% of Zn was incorporated into newly formed Zn precipitates. Contrary to the non-treated soil, the treated soil did not contain gahnite or sphalerite; it is possible that these minerals were dissolved under the higher pH conditions at the time of treatment. Desorption experiments, using a stirred flow technique with a 0.1 mol/L CaCl (sub 2) (pH 6.5) and a HNO (sub 3) (pH 4.0) solution were employed to determine the exchangeable Zn fraction and the Zn fraction which will be mobilized under more extreme weathering conditions, respectively. No significant differences were found in desorption behavior between the treated vs. non-treated soil. Bioavailability tests, using the R. metallidurans AE1433 biosensor showed that approximately 8% of total Zn was bioavailable in both the treated and non-treated soils. It was concluded that the incorporation of Zn into newly formed precipitates in both the treated and non treated soils leads to a significant natural attenuation of the exchangeable/bioavailable Zn fraction at near neutral pH conditions. At lower pHs, conditions not favorable to the formation of Zn precipitates, the pool of Zn associated with the secondary Zn precipitates is potentially more bioavailable. JF - Geochimica et Cosmochimica Acta AU - Nachtegaal, Maarten AU - Marcus, M A AU - Sonke, J E AU - Vangronsveld, Jaco AU - Livi, K J T AU - van der Lelie, Daniel AU - Sparks, D L Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 4649 EP - 4664 PB - Pergamon, Oxford VL - 69 IS - 19 SN - 0016-7037, 0016-7037 KW - solute transport KW - silicates KW - zinc KW - desorption KW - Ralstonia metallidurans KW - mass spectra KW - bioavailability KW - remediation KW - electron probe data KW - mineral composition KW - orthosilicates KW - X-ray fluorescence spectra KW - spectra KW - chemical composition KW - geochemistry KW - smelting KW - pH KW - soils KW - mines KW - in situ KW - pollutants KW - pollution KW - nesosilicates KW - ICP mass spectra KW - biogenic processes KW - Ralstonia KW - willemite KW - phenakite group KW - precipitation KW - metals KW - bacteria KW - EXAFS data KW - mobilization KW - microorganisms KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51630916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Effects+of+in+situ+remediation+on+the+speciation+and+bioavailability+of+zinc+in+a+smelter+contaminated+soil&rft.au=Nachtegaal%2C+Maarten%3BMarcus%2C+M+A%3BSonke%2C+J+E%3BVangronsveld%2C+Jaco%3BLivi%2C+K+J+T%3Bvan+der+Lelie%2C+Daniel%3BSparks%2C+D+L&rft.aulast=Nachtegaal&rft.aufirst=Maarten&rft.date=2005-10-01&rft.volume=69&rft.issue=19&rft.spage=4649&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/10.1016%2Fj.gca.2005.05.019 L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2006-01-01 N1 - Number of references - 72 N1 - Document feature - illus. incl. 3 tables, 2 plates N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - bacteria; bioavailability; biogenic processes; chemical composition; chemical fractionation; desorption; electron probe data; EXAFS data; geochemistry; ICP mass spectra; in situ; mass spectra; metals; microorganisms; mineral composition; mines; mobilization; nesosilicates; orthosilicates; pH; phenakite group; pollutants; pollution; precipitation; Ralstonia; Ralstonia metallidurans; remediation; silicates; smelting; soils; solute transport; spectra; willemite; X-ray fluorescence spectra; zinc DO - http://dx.doi.org/10.1016/j.gca.2005.05.019 ER - TY - JOUR T1 - Fabric and uranyl retention of neomorphosed aragonite botryoids; constraints on the diagenetic process AN - 51558596; 2006-062146 AB - Folk pioneered the recognition of aragonite precursors, speculation on elemental interactions with carbonates, and utilization of his white-card technique to reveal relict fabric and distribution of organics. We propose that the degree of fabric retention and trace-element behavior can be used to gain insight into processes of neomorphism of aragonite to calcite. Our examples are relict botryoidal aragonite cement fabrics preserved in mosaic calcites of the Upper Carboniferous Laborcita algal mounds (Sacramento Mts, N.M.). Their brown color and pleochroism have been attributed to ubiquitous fine-scale organic inclusions. The white-card technique reveals that the better the fabric preservation, the more uniform and brown the color. The fibrous fabric is mainly preserved by solid opaque organic and other non-carbonate inclusions. Inclusions of relict aragonite are oriented with growth direction. The calcite with the relict aragonite fabric has 4.1-4.6 ppm U and 1000-2000 ppm Sr. Preliminary synchrotron X-ray analyses of the intermediate energy U-M5 edge shows U is mainly in the oxidized state (uranyl ion). Modern marine aragonite cements have approximately 4 ppm U and 8,000-10,000 ppm Sr. If the Carboniferous aragonite had concentrations similar to the modern, then U was largely retained while Sr was decreased up to 90%. Paradoxically, based on distribution coefficients (Kd's), more U than Sr should have been lost during the replacement of aragonite by calcite (Kd for Sr+2 in calcite is 0.05 to 0.14; Kd for U+6 is 0.002-0.05). We propose that in the reaction zone during replacement U was either physically trapped or sequestered by another phase. It is unlikely that the uranyl ion alone was trapped because it is similar in size to CO3. However, if a uranyl-organic-matter complex was originally incorporated into the aragonite, then such a molecule may have been larger than the "sieve size" of the reaction zone. This scenario predicts homogeneous distribution of U. Alternatively, the uranyl ion may have been sequestered by the organics or oxides defining the relict fabric. This predicts a heterogeneous distribution with U concentrated in opaque inclusions. Both scenarios are consistent with U retention coupled with fabric preservation. JF - Abstracts with Programs - Geological Society of America AU - Rasbury, E Troy AU - Ward, W Bruce AU - Northrup, Paul A AU - Anonymous Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 254 PB - Geological Society of America (GSA), Boulder, CO VL - 37 IS - 7 SN - 0016-7592, 0016-7592 KW - United States KW - processes KW - Sacramento Mountains KW - aragonite KW - Paleozoic KW - Carboniferous KW - uranyl ion KW - crystal growth KW - New Mexico KW - Upper Carboniferous KW - calcite KW - pleochroism KW - partition coefficients KW - X-ray data KW - metals KW - diagenesis KW - uranium KW - trace elements KW - fabric KW - carbonates KW - actinides KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51558596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Fabric+and+uranyl+retention+of+neomorphosed+aragonite+botryoids%3B+constraints+on+the+diagenetic+process&rft.au=Rasbury%2C+E+Troy%3BWard%2C+W+Bruce%3BNorthrup%2C+Paul+A%3BAnonymous&rft.aulast=Rasbury&rft.aufirst=E&rft.date=2005-10-01&rft.volume=37&rft.issue=7&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2005 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2006-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - actinides; aragonite; calcite; carbonates; Carboniferous; crystal growth; diagenesis; fabric; metals; New Mexico; Paleozoic; partition coefficients; pleochroism; processes; Sacramento Mountains; trace elements; United States; Upper Carboniferous; uranium; uranyl ion; X-ray data ER - TY - JOUR T1 - Kinetics study on separation of cadmium from tellurium in acidic solution media using ion-exchange resins AN - 19672333; 6691643 AB - The feasibility of using ion-exchange resins to separate cadmium from tellurium in acidic solutions of the two metals was investigated. We studied the competitive adsorption of cadmium and tellurium in such resins under varying acid strengths and contact time. We found that low sulfuric acid strength (i.e., 0.5 M) was most effective in removing cadmium from solutions. Different ion- exchange resins were tested for their affinity for cadmium and tellurium ions. In the selected systems, the ion-exchange rate of cadmium was rapid in the first 20 min, and reached equilibrium within 2 h. The Lagergren first-order model described the kinetic data with high coefficient of determination and correlation values. At room temperatures the ion-exchange for cadmium onto the resin followed the Freundlich isotherm model. The maximum removal of cadmium obtained from batch studies using resin A was 91%. Column studies with the same resin showed a removal of cadmium of 99.99% or higher. JF - Journal of Hazardous Materials AU - Wang, Wenming AU - Fthenakis, Vasilis AD - National Photovoltaic Environmental Health and Safety Research Center, Brookhaven National Laboratory, Upton, NY 11973, USA, vmf@bnl.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 80 EP - 88 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 125 IS - 1-3 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts KW - Cadmium KW - Tellurium KW - Waste management KW - Ion-exchange KW - Recycling KW - Photovoltaics KW - Feasibility studies KW - Heavy metals KW - tellurium KW - Models KW - Sulfuric acid KW - Isotherms KW - Ion exchange KW - Temperature effects KW - Metals KW - Ions KW - Resins KW - Data processing KW - Temperature KW - affinity KW - Kinetics KW - Adsorption KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19672333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Kinetics+study+on+separation+of+cadmium+from+tellurium+in+acidic+solution+media+using+ion-exchange+resins&rft.au=Wang%2C+Wenming%3BFthenakis%2C+Vasilis&rft.aulast=Wang&rft.aufirst=Wenming&rft.date=2005-10-01&rft.volume=125&rft.issue=1-3&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2005.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ions; Resins; Data processing; Heavy metals; Kinetics; tellurium; Adsorption; Sulfuric acid; Cadmium; Isotherms; Models; Feasibility studies; Metals; Tellurium; Temperature; Ion exchange; affinity DO - http://dx.doi.org/10.1016/j.jhazmat.2005.02.013 ER - TY - JOUR T1 - Cytotoxic Effects of Low- and High-LET Radiation on Human Neuronal Progenitor Cells: Induction of Apoptosis and TP53 Gene Expression AN - 17384149; 6485791 AB - The induction of apoptosis, TP53 expression, caspase activation and cell toxicity were investigated after exposure of cells of the human neuronal progenitor cell line Ntera2 (NT2) to low-LET radiation ( gamma and X rays). The data indicates that irradiation of NT2 cells quickly induced TP53 expression, which was followed in time by an increase in caspase activity, and ultimately resulted in the induction of apoptosis. Induction of apoptosis was dependent on dose, and the highest levels were measured 48 h after exposure. For comparison, the level of apoptosis induced by high-LET particle radiation (1 GeV/nucleon iron ions) was also determined and was found to be dependent on dose. The relative biological effectiveness (RBE) was estimated from the slopes of the dose-response curves for the induction of apoptosis. The RBE sub(max) for apoptosis 48 h after exposure was at least 3.4. In short, exposure to high-LET radiation results in a more efficient and greater induction of apoptosis in human neuronal progenitor cells than low-LET radiation. JF - Radiation Research AU - Guida, P AU - Vazquez, ME AU - Otto, S AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973 Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 545 EP - 551 PB - Radiation Research Society VL - 164 IS - 4 SN - 0033-7587, 0033-7587 KW - Genetics Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Ions KW - X radiation KW - alpha Radiation KW - Apoptosis KW - Data processing KW - Toxicity KW - p53 protein KW - Cell activation KW - Gene expression KW - Stem cells KW - Cytotoxicity KW - Radiation KW - gamma Radiation KW - Neurotrophin 2 KW - Caspase KW - Iron KW - Neural stem cells KW - X 24210:Radiation & radioactive materials KW - N3 11101:General KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17384149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Cytotoxic+Effects+of+Low-+and+High-LET+Radiation+on+Human+Neuronal+Progenitor+Cells%3A+Induction+of+Apoptosis+and+TP53+Gene+Expression&rft.au=Guida%2C+P%3BVazquez%2C+ME%3BOtto%2C+S&rft.aulast=Guida&rft.aufirst=P&rft.date=2005-10-01&rft.volume=164&rft.issue=4&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1043%2F0033-7587%282005%291642.0.CO%3B2 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=164&issue=4&page=545 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ions; alpha Radiation; X radiation; Data processing; Apoptosis; Toxicity; Cell activation; p53 protein; Gene expression; Cytotoxicity; Stem cells; Radiation; Neurotrophin 2; gamma Radiation; Caspase; Neural stem cells; Iron DO - http://dx.doi.org/10.1043/0033-7587(2005)164[0545:CEOLAH]2.0.CO;2 ER - TY - JOUR T1 - Endogenous DNA damage clusters in human skin, 3-D model, and cultured skin cells. AN - 68497076; 16109312 AB - Clustered damages-two or more oxidized bases, abasic sites, or strand breaks on opposing DNA strands within a few helical turns-are formed in DNA by ionizing radiation. Clusters are difficult for cells to repair and thus pose significant challenges to genomic integrity. Although endogenous clusters were found in some permanent human cell lines, it was not known if clusters accumulated in human tissues or primary cells. Using high-sensitivity gel electrophoresis, electronic imaging, and number average length analysis, we determined endogenous cluster levels in DNA from human skin, a 3-D skin model, and primary cultured skin cells. DNA from dermis and epidermis of human skin contained extremely low levels of endogenous clusters (a few per gigabase). However, cultured skin fibroblasts and keratinocytes-whether in monolayer cultures or in 3-D model skin cultures-accumulated oxidized pyrimidine, oxidized purine, and abasic clusters. The levels of endogenous clusters were decreased by growing cells in the presence of selenium or by increasing cellular levels of Fpg protein, presumably by increasing processing of clustered damages. These results imply that the levels of endogenous clusters can be affected by the cells' external environment and their ability to deal with DNA damage. JF - Free radical biology & medicine AU - Bennett, Paula V AU - Cuomo, Noelle L AU - Paul, Sunirmal AU - Tafrov, Stefan T AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 832 EP - 839 VL - 39 IS - 6 SN - 0891-5849, 0891-5849 KW - Purines KW - 0 KW - Pyrimidines KW - DNA KW - 9007-49-2 KW - pyrimidine KW - K8CXK5Q32L KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - DNA Repair KW - Dermis -- cytology KW - Oxygen -- metabolism KW - Epidermis -- cytology KW - Humans KW - Pyrimidines -- pharmacology KW - Dose-Response Relationship, Radiation KW - Fibroblasts -- metabolism KW - Cells, Cultured KW - Electrophoresis, Agar Gel KW - Purines -- pharmacology KW - CHO Cells KW - Keratinocytes -- cytology KW - Purines -- chemistry KW - Radiation, Ionizing KW - Cricetinae KW - Skin -- radiation effects KW - DNA Damage KW - Skin -- metabolism KW - DNA -- metabolism KW - Skin -- pathology KW - Skin -- cytology KW - DNA -- chemistry KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68497076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Analysis+of+Morris+Water+Maze+Data+from+HVS+Running+Systems+Using+Microsoft+Excel+and+Sigma+Stat&rft.au=Flavin%2C+N+J%3BNeill%2C+J+C&rft.aulast=Flavin&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-20 N1 - Date created - 2005-08-19 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Mutat Res. 2002 Nov 30;509(1-2):23-34 [12427529] Oncogene. 2002 Dec 16;21(58):8926-34 [12483509] Free Radic Biol Med. 2002 Jun 1;32(11):1102-15 [12031895] Radiat Res. 2002 Jun;157(6):611-6 [12005538] Acta Biochim Pol. 2000;47(4):1197-8 [11996110] J Inherit Metab Dis. 2002 May;25(3):215-22 [12137230] Nucleic Acids Res. 2002 Jul 1;30(13):2800-8 [12087163] Biol Chem. 2002 Mar-Apr;383(3-4):467-75 [12033436] J Biol Chem. 2003 Mar 14;278(11):9005-12 [12519758] Biochemistry. 2003 Mar 25;42(11):3375-84 [12641470] Free Radic Biol Med. 2003 Sep 1;35(5):495-503 [12927599] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12871-6 [14566050] Free Radic Biol Med. 2004 Jan 15;36(2):259-66 [14744637] Nucleic Acids Res. 2004;32(4):1602-9 [15004247] Free Radic Biol Med. 2004 Aug 15;37(4):488-99 [15256220] DNA Repair (Amst). 2004 Oct 5;3(10):1323-34 [15336627] Semin Cancer Biol. 2004 Dec;14(6):441-8 [15489137] Nucleic Acids Res. 2004;32(18):5609-20 [15494449] Photochem Photobiol. 1975 May;21(5):373-5 [1208665] Somat Cell Mol Genet. 1986 Mar;12(2):185-95 [3008351] Anal Biochem. 1986 Oct;158(1):119-29 [3799960] Anal Biochem. 1987 Jun;163(2):446-57 [3661993] Radiat Res. 1993 Jun;134(3):307-15 [8316623] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22 [8367443] Int J Radiat Biol. 1994 Jan;65(1):7-17 [7905912] Int J Radiat Biol. 1994 Nov;66(5):427-32 [7983426] Nucleic Acids Res. 1994 Nov 25;22(23):4943-6 [7800484] J Mol Biol. 1995 Jun 23;249(5):914-22 [7791217] Cancer Res. 1997 Feb 1;57(3):420-5 [9012468] J Biol Chem. 1997 Jun 20;272(25):15650-5 [9188454] Carcinogenesis. 1997 Nov;18(11):2225-31 [9395225] Nucleic Acids Res. 1998 Feb 15;26(4):932-41 [9461450] Radiat Res. 1998 Nov;150(5 Suppl):S60-79 [9806610] EMBO J. 2004 Nov 10;23(22):4484-94 [15496986] J Mol Biol. 2005 Jan 28;345(4):731-43 [15588822] Tissue Eng. 2004 Sep-Oct;10(9-10):1332-45 [15588394] FASEB J. 2005 Jan;19(1):82-4 [15533950] Nucleic Acids Res. 2005;33(1):260-71 [15647508] Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5 [10557315] J Biol Chem. 2000 Apr 21;275(16):11865-73 [10766813] Biochemistry. 2000 Jul 11;39(27):8026-31 [10891084] Curr Opin Cell Biol. 2001 Apr;13(2):225-31 [11248557] Mutat Res. 2001 Apr 18;475(1-2):7-20 [11295149] Electrophoresis. 2001 Mar;22(5):843-54 [11332751] Free Radic Biol Med. 2001 Jun 15;30(12):1418-25 [11390187] N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Biotransformation of Uranium Complexed with Organic Ligands T2 - 4th International Conference on Uranium Mining and Hydrogeology (UMH IV) AN - 39649096; 3980286 JF - 4th International Conference on Uranium Mining and Hydrogeology (UMH IV) AU - Francis, A J Y1 - 2005/09/11/ PY - 2005 DA - 2005 Sep 11 KW - Uranium KW - Biotransformation KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39649096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Aging+and+Seizures+on+Auditory+Discrimination&rft.au=Neill%2C+J+C%3BHolmes%2C+G+L&rft.aulast=Neill&rft.aufirst=J&rft.date=2005-11-12&rft.volume=27&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+Criminal+Justice+Education&rft.issn=10511253&rft_id=info:doi/10.1080%2F10511253.2015.1078387 L2 - http://www.geo.tu-freiberg.de/umh/Accepted%20Papers.htm#Topic1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Data Supporting an Important Role for Wavelengths Greater than UVB in Inducing Melanomas T2 - 6th World Congress on Melanoma AN - 40029906; 3994387 JF - 6th World Congress on Melanoma AU - Setlow, R Y1 - 2005/09/06/ PY - 2005 DA - 2005 Sep 06 KW - Melanoma KW - Wavelength KW - U.V. radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40029906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Melanoma&rft.atitle=Data+Supporting+an+Important+Role+for+Wavelengths+Greater+than+UVB+in+Inducing+Melanomas&rft.au=Setlow%2C+R&rft.aulast=Setlow&rft.aufirst=R&rft.date=2005-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Melanoma&rft.issn=&rft_id=info:doi/ L2 - http://www.venuewest.com/worldmelanoma/images/6th_Melanoma_Web_Final.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural Analysis of Botulinum Neurotoxin Serotype F Light Chain: Implications on Substrate Binding and Inhibitor Design AN - 19847615; 6757725 AB - The seven serologically distinct Clostridium botulinum neurotoxins (BoNTs A-G) are zinc endopeptidases which block the neurotransmitter release by cleaving one of the three proteins of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor complex (SNARE complex) essential for the fusion of vesicles containing neurotransmitters with target membranes. These metallopeptidases exhibit unique specificity for the substrates and peptide bonds they cleave. Development of countermeasures and therapeutics for BoNTs is a priority because of their extreme toxicity and potential misuse as biowarfare agents. Though they share sequence homology and structural similarity, the structural information on each one of them is required to understand the mechanism of action of all of them because of their specificity. Unraveling the mechanism will help in the ultimate goal of developing inhibitors as antibotulinum drugs for the toxins. Here, we report the high-resolution structure of active BoNT/F catalytic domain in two crystal forms. The structure was exploited for modeling the substrate binding and identifying the S1' subsite and the putative exosites which are different from BoNT/A or BoNT/B. The orientation of docking of the substrate at the active site is consistent with the experimental BoNT/A-LC:SNAP-25 peptide model and our proposed model for BoNT/E-LC:SNAP-25. JF - Biochemistry (Washington) AU - Agarwal, R AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2005/09/06/ PY - 2005 DA - 2005 Sep 06 SP - 11758 EP - 11765 VL - 44 IS - 35 SN - 0006-2960, 0006-2960 KW - botulinum toxin type F KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Light chains KW - Serotypes KW - zinc endopeptidase KW - Clostridium botulinum KW - Crystals KW - Toxicity KW - SNAP receptors KW - Toxins KW - Metalloproteinase KW - Homology KW - SNAP-25 protein KW - Crystal structure KW - Neurotransmitters KW - Botulinum toxin KW - Neurotoxins KW - Drugs KW - Neurotransmitter release KW - Vesicle fusion KW - J 02822:Biosynthesis and physicochemical properties KW - X 24360:Metals KW - N3 11070:Neurochemistry and cellular biology KW - A 01023:Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Optical+Brain+Monitoring+of+Cerebrovascular+and+Intracellular+Calcium+Effects+Induced+by+Acute+Cocaine+Exposure+in+the+Living+Rat&rft.au=Du%2C+C.%3BThanos%2C+P+K%3BYu%2C+M.%3BRivera%2C+S%3BBenveniste%2C+H&rft.aulast=Du&rft.aufirst=C.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Light chains; Serotypes; zinc endopeptidase; Toxicity; Crystals; Toxins; SNAP receptors; Metalloproteinase; Homology; SNAP-25 protein; Crystal structure; Botulinum toxin; Neurotransmitters; Neurotoxins; Drugs; Neurotransmitter release; Vesicle fusion; Clostridium botulinum DO - http://dx.doi.org/10.1021/bi0510072 ER - TY - JOUR T1 - My early days in photobiology with Philip Hanawalt AN - 19821164; 6513056 AB - Phil and I started our careers on somewhat similar scientific paths. I had an undergraduate degree in physics from Swarthmore College and a Ph.D. degree in physics from Yale for research in the field for ultraviolet spectroscopy. Phil received an undergraduate degree in Physics from Oberlin College, joined the Yale Physics Department in 1954, and transferred to the new Biophysics Department in 1955. We began our interactions then by virtue of the fact that Phil had to take a Laboratory Course in Experimental Physics, one part of which was spectroscopy in which I was the instructor. One of my principal interests was in the effects of different wavelengths of ultraviolet (UV) radiation on proteins, viruses and bacterial cells. So what was more natural than for Phil to dream up a Ph.D. research project to investigate the effects of different wavelengths of UV on macromolecular synthesis in Escherichia coli. I became his mentor with expertise in UV, whereas he did most of the microbiological/biochemical work. Thus began a collaboration and a communicating friendship, the latter going on for 50 years. That communication was essential in elucidating some of the important steps in nucleotide excision repair-a field in which Phil is a pre-eminent scholar and investigator. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Setlow, R B AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA, setlow@bnl.gov Y1 - 2005/09/04/ PY - 2005 DA - 2005 Sep 04 SP - 4 EP - 8 VL - 577 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Dreams KW - Macromolecules KW - U.V. radiation KW - Escherichia coli KW - Communication KW - Wavelength KW - Spectroscopy KW - Nucleotides KW - Biophysics KW - Mutagenesis KW - N 14025:RNA/DNA role in infection & immune response KW - J 02320:Cell Biology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19821164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Long+-+term+Effects+of+Whole+-+brain+Irradiation+on+Auditory+Discrimination&rft.au=Aubele%2C+T+M%3BKristiansen%2C+R%3BMurphy%2C+M%3BRice%2C+O%3BGately%2C+S+J&rft.aulast=Aubele&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Macromolecules; Dreams; U.V. radiation; Communication; Wavelength; Spectroscopy; Nucleotides; Mutagenesis; Biophysics; Escherichia coli DO - http://dx.doi.org/10.1016/j.mrfmmm.2005.01.031 ER - TY - JOUR T1 - Hierarchical approach to model multilayer colloidal deposition in porous media. AN - 68633299; 16190188 AB - Particle deposition is important in many environmental systems such as water and wastewater filtration, air pollution control, subsurface transport, biofilm formation and fouling, and thin film synthesis for use in remediation technologies. While continuum-level models have been developed to predict deposition dynamics in these systems, these models fail to explain transient dynamics of multilayer deposition from a mechanistic viewpoint. In this work, a multiscale approach has been developed to predict multiple layer irreversible colloidal deposition in the presence of interparticle electrostatic and van der Waals interactions in porous media. The approach combines the kinetic information obtained from the mesoscopic stochastic simulations of particle deposition with the macroscopic conservation equation describing colloidal transport. Sequential Brownian dynamics simulations are first performed by accounting for particle-particle (P-P) and particle-surface (P-S) interactions, and multilayered particle deposits are obtained. The available surface function quantifying the deposition kinetics is then obtained from the deposit microstructure. Deposition dynamics are studied at different ionic strengths and particle potentials that control the range and magnitude of interparticle interactions. Simulation results showed that the microstructure of the particle deposits formed under the influence of P-P and P-S electrostatic interactions exhibited significant variations with respect to ionic strength and could be qualitatively explained bythe interplay between the repulsive and attractive P-P and P-S interaction forces. The available surface function also varied significantly as a function of ionic strength. This basic understanding of the deposition dynamics at the mesoscale was then combined with the continuum-level transport equations to predict particle breakthrough curves in porous media. The approach is capable of capturing transient features of deposition dynamics, as demonstrated by the good agreement between the model predictions and the experimental observations. JF - Environmental science & technology AU - Kulkarni, Pramod AU - Sureshkumar, R AU - Biswas, Pratim AD - Brookhaven National Laboratory, P.O. Box 5000, Building 815E, Upton, New York 11973, USA. Y1 - 2005/09/01/ PY - 2005 DA - 2005 Sep 01 SP - 6361 EP - 6370 VL - 39 IS - 17 SN - 0013-936X, 0013-936X KW - Colloids KW - 0 KW - Water Pollutants KW - Index Medicus KW - Static Electricity KW - Osmolar Concentration KW - Kinetics KW - Porosity KW - Adsorption KW - Surface Properties KW - Nanostructures KW - Models, Theoretical KW - Water Pollutants -- analysis KW - Colloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68633299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harvard+Law+Review&rft.atitle=Systemic+Facts%3A+Toward+Institutional+Awareness+in+Criminal+Courts&rft.au=Crespo%2C+Andrew+Manuel&rft.aulast=Crespo&rft.aufirst=Andrew&rft.date=2016-06-01&rft.volume=129&rft.issue=8&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Harvard+Law+Review&rft.issn=0017811X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-09-29 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A Multifunctional Acyl-Acyl Carrier Protein Desaturase from Hedera helix L. (English Ivy) Can Synthesize 16- and 18-Carbon Monoene and Diene Products AN - 19766414; 6414838 AB - A desaturase with 83% sequence identity to the coriander Delta super(4)-16:0-ACP desaturase was isolated from developing seeds of Hedera helix (English ivy). Expression of the ivy desaturase in Arabidopsis resulted in the accumulation of 16:1 Delta super(4) and its expected elongation product 18:1 Delta super(6) (petroselinic acid). Expression in Escherichia coli resulted in the accumulation of soluble, active protein that was purified to apparent homogeneity. In vitro assays confirmed Delta super(4) desaturation with 16:0-ACP; however, with 18:0-acyl acyl carrier protein (ACP) desaturation occurred at the Delta super(9) position. The ivy desaturase also converted 16:1 Delta super(9)-ACP and 18:1 Delta super(9)-ACP to the corresponding Delta super(4,9) dienes. These data suggest at least two distinct substrate binding modes, one placing C4 at the diiron active site and the other placing C9 at the active site. In the latter case, 18:0 would likely bind in an extended conformation as described for the castor desaturase with 9-carbons accommodated in the cavity beyond the dirron site. However, Delta super(4) desaturation would require the accommodation of 12 carbons for C16 substrates or 14 carbons for C18 substrates. The amino acids lining the substrate binding cavity of ivy and castor desaturases are conserved except for T117R and P179I (castor/ivy). Paradoxically, both substitutions, when introduced into the castor desaturase, favored the binding of shorter acyl chains. Thus, it seems likely that Delta super(4) desaturation would require a non-extended, perhaps U-shaped, substrate conformation. A cis double bond may facilitate the initiation of such a non-extended conformation in the monounsaturated substrates. The multifunctional properties of the ivy desaturase make it well suited for further dissection of the determinants of regiospecificity. JF - Journal of Biological Chemistry AU - Whittle, Edward AU - Cahoon, Edgar B AU - Subrahmanyam, Satyam AU - Shanklin, John AD - Biology Department, Brookhaven National Laboratory, Upton, New York, 11973 and United States Department of Agriculture-Agricultural Research Service Plant Genetics Research Unit, Donald Danforth Plant Science Center, St. Louis, Missouri 63132 Y1 - 2005/08/05/ PY - 2005 DA - 2005 Aug 05 SP - 28169 EP - 28176 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 31 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Cavities KW - Seeds KW - Data processing KW - Amino acids KW - Hedera helix KW - Elongation KW - Carbon KW - Escherichia coli KW - Castor KW - Arabidopsis KW - desaturase KW - Acyl carrier protein KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Multifunctional+Acyl-Acyl+Carrier+Protein+Desaturase+from+Hedera+helix+L.+%28English+Ivy%29+Can+Synthesize+16-+and+18-Carbon+Monoene+and+Diene+Products&rft.au=Whittle%2C+Edward%3BCahoon%2C+Edgar+B%3BSubrahmanyam%2C+Satyam%3BShanklin%2C+John&rft.aulast=Whittle&rft.aufirst=Edward&rft.date=2005-08-05&rft.volume=280&rft.issue=31&rft.spage=28169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Elongation; Cavities; Seeds; Amino acids; Data processing; Carbon; desaturase; Acyl carrier protein; Hedera helix; Escherichia coli; Castor; Arabidopsis ER - TY - JOUR T1 - Interactions of uranium with bacteria and kaolinite clay AN - 51678255; 2005-062511 AB - We assessed the accumulation of uranium (VI) by a bacterium, Bacillus subtilis, suspended in a slurry of kaolinite clay, to elucidate the role of microbes on the mobility of U(VI). Various mixtures of bacteria and the kaolinite were exposed to solutions of 8X10 (super -6) M- and 4X10 (super -4) M-U(VI) in 0.01 M NaCl at pH 4.7. After 48 h, the mixtures were separated from the solutions by centrifugation, and treated with a 1 M CH (sub 3) COOK for 24 h to determine the associations of U within the mixture. The mixture exposed to 4X10 (super -4) M U was analyzed by transmission electron microscope (TEM) equipped with EDS. The accumulation of U by the mixture increased with an increase in the amount of B. subtilis cells present at both U concentrations. Treatment of kaolinite with CH (sub 3) COOK, removed approximately 80% of the associated uranium. However, in the presence of B. subtilis the amount of U removed was much less. TEM-EDS analysis confirmed that most of the U removed from solution was associated with B. subtilis. XANES analysis of the oxidation state of uranium associated with B. subtilis, kaolinite, and with the mixture containing both revealed that it was present as U(VI). These results suggest that the bacteria have a higher affinity for U than the kaolinite clay mineral under the experimental conditions tested, and that they can immobilize significant amount of uranium. JF - Chemical Geology AU - Ohnuki, Toshihiko AU - Yoshida, T AU - Ozaki, T AU - Samadfam, M AU - Kozai, N AU - Yubuta, K AU - Mitsugashira, T AU - Kasama, T AU - Francis, A J Y1 - 2005/08// PY - 2005 DA - August 2005 SP - 237 EP - 243 PB - Elsevier, Amsterdam VL - 220 IS - 3-4 SN - 0009-2541, 0009-2541 KW - silicates KW - kaolinite KW - solution KW - X-ray spectra KW - TEM data KW - energy dispersive X-ray spectra KW - clay minerals KW - XANES spectra KW - biogenic processes KW - water-rock interaction KW - metals KW - bacteria KW - sheet silicates KW - uranium KW - spectra KW - mobilization KW - chemical composition KW - geochemistry KW - Bacillus KW - actinides KW - microorganisms KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51678255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Interactions+of+uranium+with+bacteria+and+kaolinite+clay&rft.au=Biegon%2C+A%3BPareto%2C+D%3BGuol%2C+J%3BKofke%2C+W&rft.aulast=Biegon&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 26 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - actinides; Bacillus; bacteria; biogenic processes; chemical composition; clay minerals; energy dispersive X-ray spectra; geochemistry; kaolinite; metals; microorganisms; mobilization; sheet silicates; silicates; solution; spectra; TEM data; uranium; water-rock interaction; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2005.03.008 ER - TY - JOUR T1 - Comparative evaluation of positron emission tomography radiotracers for imaging the norepinephrine transporter: (S,S) and (R,R) enantiomers of reboxetine analogs ([11C]methylreboxetine, 3-Cl-[11C]methylreboxetine and [18F]fluororeboxetine), (R)-[11C]nisoxetine, [11C]oxaprotiline and [11C]lortalamine. AN - 68011882; 15998285 AB - We have synthesized and evaluated several new ligands for imaging the norepinephrine transporter (NET) system in baboons with positron emission tomography (PET). Ligands possessing high brain penetration, high affinity and selectivity, appropriate lipophilicity (log P = 1.0-3.5), high plasma free fraction and reasonable stability in plasma were selected for further studies. Based on our characterization studies in baboons, including 11C-labeled (R)-nisoxetine (Nis), oxaprotiline (Oxap), lortalamine (Lort) and new analogs of methylreboxetine (MRB), in conjunction with our earlier evaluation of 11C and 18F derivatives of reboxetine, MRB and their individual (R,R) and (S,S) enantiomers, we have identified the superiority of (S,S)-[11C]MRB and the suitability of MRB analogs [(S,S)-[11C]MRB > (S,S)-[11C]3-Cl-MRB > (S,S)-[18F]fluororeboxetine] as potential NET ligands for PET. In contrast, Nis, Oxap and Lort displayed high uptake in striatum (higher than in thalamus). The use of these ligands is further limited by high non-specific binding and relatively low specific signal, as is characteristic of many earlier NET ligands. Thus, to our knowledge (S,S)-[11C]MRB remains by far the most promising NET ligand for PET studies. JF - Journal of neurochemistry AU - Ding, Yu-Shin AU - Lin, Kuo-Shyan AU - Logan, Jean AU - Benveniste, Helene AU - Carter, Pauline AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. ding@bnl.gov Y1 - 2005/07// PY - 2005 DA - July 2005 SP - 337 EP - 351 VL - 94 IS - 2 SN - 0022-3042, 0022-3042 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Benzopyrans KW - Carbon Radioisotopes KW - Fluorine Radioisotopes KW - Morpholines KW - Norepinephrine Plasma Membrane Transport Proteins KW - Slc6a2 protein, mouse KW - Symporters KW - Fluoxetine KW - 01K63SUP8D KW - nisoxetine KW - 17NV064B2D KW - Maprotiline KW - 2U1W68TROF KW - hydroxymaprotilin KW - 3V3Z2HK4LS KW - reboxetine KW - 947S0YZ36I KW - lortalamine KW - 9GIR4SV22T KW - Nordefrin KW - R81X549E70 KW - Index Medicus KW - Papio KW - Animals KW - Drug Interactions KW - Fluorine Radioisotopes -- pharmacokinetics KW - Dose-Response Relationship, Drug KW - Brain Chemistry KW - Adrenergic Uptake Inhibitors -- pharmacokinetics KW - Binding, Competitive -- drug effects KW - Mice KW - Tissue Distribution KW - Adrenergic Uptake Inhibitors -- blood KW - Image Processing, Computer-Assisted -- methods KW - Carbon Radioisotopes -- pharmacokinetics KW - Evaluation Studies as Topic KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Protein Binding -- drug effects KW - Nordefrin -- antagonists & inhibitors KW - Chromatography, High Pressure Liquid -- methods KW - Autoradiography -- methods KW - Time Factors KW - Radioligand Assay -- methods KW - Maprotiline -- analogs & derivatives KW - Morpholines -- pharmacokinetics KW - Fluoxetine -- analogs & derivatives KW - Maprotiline -- pharmacokinetics KW - Positron-Emission Tomography KW - Symporters -- metabolism KW - Fluoxetine -- blood KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Morpholines -- blood KW - Fluoxetine -- pharmacokinetics KW - Benzopyrans -- pharmacokinetics KW - Benzopyrans -- blood KW - Maprotiline -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68011882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Comparative+evaluation+of+positron+emission+tomography+radiotracers+for+imaging+the+norepinephrine+transporter%3A+%28S%2CS%29+and+%28R%2CR%29+enantiomers+of+reboxetine+analogs+%28%5B11C%5Dmethylreboxetine%2C+3-Cl-%5B11C%5Dmethylreboxetine+and+%5B18F%5Dfluororeboxetine%29%2C+%28R%29-%5B11C%5Dnisoxetine%2C+%5B11C%5Doxaprotiline+and+%5B11C%5Dlortalamine.&rft.au=Ding%2C+Yu-Shin%3BLin%2C+Kuo-Shyan%3BLogan%2C+Jean%3BBenveniste%2C+Helene%3BCarter%2C+Pauline&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2005-07-01&rft.volume=94&rft.issue=2&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-07 N1 - Date created - 2005-07-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Decontamination of Uranium-Contaminated Steel Surfaces by Hydroxycarboxylic Acid with Uranium Recovery AN - 19812140; 6433740 AB - We developed a simple, safe method to remove uranium from contaminated metallic surfaces so that the materials can be recycled or disposed of as low-level radioactive or nonradioactive waste. Surface analysis of rusted uranium-contaminated plain carbon-steel coupons by X-ray photoelectron spectroscopy and Rutherford backscattering spectroscopy showed that uranium was predominantly associated with ferrihydrite, lepidocrocite, and magnetite, or occluded in the matrix of the corrosion product as uranyl hydroxide and schoepite (UO sub(3) times 2H sub(2)O). Citric acid formulations, consisting of oxalic acid-hydrogen peroxide-citric acid (OPC) or citric acid-hydrogen peroxide-citric acid (CPC), were used to remove uranium from the coupons. The efficiency of uranium removal varied from 68% to 94% depending on the extent of corrosion, the association of uranium with the iron oxide matrix, and the accessibility of the occluded contaminant. Decontaminated coupons clearly showed evidence of the extensive removal of rust and uranium. The waste solutions containing uranium and iron from decontamination by OPC and CPC were treated first by subjecting them to biodegradation followed by photodegradation. Biodegradation of a CPC solution by Pseudomonas fluorescens resulted in the degradation of the citric acid with concomitant precipitation of Fe (>96%), whereas U that remained in solution was recovered (>99%) by photodegradation as schoepite. In contrast, in an OPC solution citric acid was biodegraded but not oxalic acid, and both Fe and U remained in solution. Photodegradation of this OPC solution resulted in the precipitation of iron as ferrihydrite and uranium as uranyl hydroxide. JF - Environmental Science & Technology AU - Francis, A J AU - Dodge, C J AU - McDonald, JA AU - Halada, G P AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA, francis1@bnl.gov Y1 - 2005/07/01/ PY - 2005 DA - 2005 Jul 01 SP - 5015 EP - 5021 VL - 39 IS - 13 SN - 0013-936X, 0013-936X KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Biodegradation KW - iron oxides KW - Wastes KW - Decontamination KW - Precipitation KW - Spectroscopy KW - Rust KW - Pseudomonas fluorescens KW - Photodegradation KW - Uranium KW - Ionizing radiation KW - Corrosion KW - Steel KW - Contaminants KW - Photoelectron spectroscopy KW - Iron KW - Oxalic acid KW - magnetite KW - Citric acid KW - A 01056:Mineral microbiology KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19812140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Decontamination+of+Uranium-Contaminated+Steel+Surfaces+by+Hydroxycarboxylic+Acid+with+Uranium+Recovery&rft.au=Francis%2C+A+J%3BDodge%2C+C+J%3BMcDonald%2C+JA%3BHalada%2C+G+P&rft.aulast=Francis&rft.aufirst=A&rft.date=2005-07-01&rft.volume=39&rft.issue=13&rft.spage=5015&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/10.1021%2Fes048887c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Biodegradation; iron oxides; Wastes; Decontamination; Precipitation; Spectroscopy; Rust; Photodegradation; Ionizing radiation; Uranium; Corrosion; Steel; Contaminants; Iron; Photoelectron spectroscopy; Oxalic acid; Citric acid; magnetite; Pseudomonas fluorescens DO - http://dx.doi.org/10.1021/es048887c ER - TY - JOUR T1 - Record of redox status in laminated sediments from Lake Titicaca; a sulfur K-edge X-ray absorption near edge structure (XANES) study AN - 51701620; 2005-047901 AB - Laminated sediments are commonly used to examine limnological and ecological processes on short time scales. Here, we examine changes in sulfur speciation of lamination couplets from Lake Titicaca, South America using X-ray absorption near edge structure (XANES) spectroscopy. The dark-colored layer of each lamination couplet contains a significant fraction of reduced organic sulfides, with smaller fractions of iron sulfides and sulfate. In contrast, the light-colored layer of each couplet is primarily composed of sulfate. In all laminae, the sulfate is present as inorganic sulfate substituted in calcite. The differences in speciation likely reflect changes in productivity during sediment deposition. During the warm, productive summer months, micritic calcite precipitation was induced in oxidized surface waters due to pH changes induced by consumption of dissolved CO (sub 2) --this calcite incorporates dissolved sulfate and forms the light-colored layers. This pulse of productivity creates organic matter that partially decomposes during the austral winter months, consuming oxygen and delivering organic-rich sediment to the lake bottom. This decomposition, and the possible presence of a halocline, kept bottom waters low in oxygen, and lead to the production of organic matter rich in reduced sulfur. These data suggest that these laminations are deposited annually and illustrate the utility of S K-edge XANES for the analysis of laminated sediments. Abstract Copyright (2005) Elsevier, B.V. JF - Chemical Geology AU - Bostick, Benjamin C AU - Theissen, K M AU - Dunbar, R B AU - Vairavamurthy, M A Y1 - 2005/06/15/ PY - 2005 DA - 2005 Jun 15 SP - 163 EP - 174 PB - Elsevier, Amsterdam VL - 219 IS - 1-4 SN - 0009-2541, 0009-2541 KW - X-ray diffraction data KW - isotopes KW - Lake Titicaca KW - Holocene KW - environmental analysis KW - carbon dioxide KW - Bolivia KW - XANES spectra KW - Cenozoic KW - radioactive isotopes KW - dates KW - carbon KW - sediments KW - absolute age KW - Peru KW - spectra KW - depositional environment KW - chemical composition KW - sedimentary structures KW - geochemistry KW - pH KW - Eh KW - monitoring KW - Quaternary KW - sulfates KW - laminations KW - sedimentation KW - solutes KW - X-ray spectra KW - South America KW - planar bedding structures KW - organic compounds KW - lacustrine environment KW - sulfur KW - seasonal variations KW - C-14 KW - SEM data KW - lake sediments KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51701620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Record+of+redox+status+in+laminated+sediments+from+Lake+Titicaca%3B+a+sulfur+K-edge+X-ray+absorption+near+edge+structure+%28XANES%29+study&rft.au=Bostick%2C+Benjamin+C%3BTheissen%2C+K+M%3BDunbar%2C+R+B%3BVairavamurthy%2C+M+A&rft.aulast=Bostick&rft.aufirst=Benjamin&rft.date=2005-06-15&rft.volume=219&rft.issue=1-4&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2005.02.004 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 42 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2014-03-14 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - absolute age; Bolivia; C-14; carbon; carbon dioxide; Cenozoic; chemical composition; chemical fractionation; dates; depositional environment; Eh; environmental analysis; geochemistry; Holocene; isotopes; lacustrine environment; lake sediments; Lake Titicaca; laminations; monitoring; organic compounds; Peru; pH; planar bedding structures; Quaternary; radioactive isotopes; seasonal variations; sedimentary structures; sedimentation; sediments; SEM data; solutes; South America; spectra; sulfates; sulfur; X-ray diffraction data; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2005.02.004 ER - TY - JOUR T1 - Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme AN - 17545960; 6407241 AB - Clostridial neurotoxins comprising the seven serotypes of botulinum neurotoxins and tetanus neurotoxin are the most potent toxins known to humans. Their potency coupled with their specificity and selectivity underscores the importance in understanding their mechanism of action in order to develop a strategy for designing counter measures against them. To develop an effective vaccine against the toxin, it is imperative to achieve an inactive form of the protein which preserves the overall conformation and immunogenicity. Inactive mutants can be achieved either by targeting active site residues or by modifying the surface charges farther away from the active site. The latter affects the long-range forces such as electrostatic potentials in a subtle way without disturbing the structural integrity of the toxin causing some drastic changes in the activity/environment. Here we report structural and biochemical analysis on several mutations on Clostridium botulinum neurotoxin type E light chain with at least two producing dramatic effects: Glu335Gln causes the toxin to transform into a persistent apoenzyme devoid of zinc, and Tyr350Ala has no hydrolytic activity. The structural analysis of several mutants has led to a better understanding of the catalytic mechanism of this family of proteins. The residues forming the S1' subsite have been identified by comparing this structure with a thermolysin-inhibitor complex structure. JF - Biochemistry (Washington) AU - Agarwal, R AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2005/06/14/ PY - 2005 DA - 2005 Jun 14 SP - 8291 EP - 8302 VL - 44 IS - 23 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Light chains KW - Serotypes KW - Apoenzymes KW - Biochemical analysis KW - Clostridium botulinum KW - Tetanus KW - Toxins KW - Structure-function relationships KW - Immunogenicity KW - Zinc KW - Vaccines KW - Neurotoxins KW - Mutation KW - J 02822:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17545960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Analysis+of+Active+Site+Residues+of+Botulinum+Neurotoxin+E+by+Mutational%2C+Functional%2C+and+Structural+Studies%3A+Glu335Gln+Is+an+Apoenzyme&rft.au=Agarwal%2C+R%3BBinz%2C+T%3BSwaminathan%2C+S&rft.aulast=Agarwal&rft.aufirst=R&rft.date=2005-06-14&rft.volume=44&rft.issue=23&rft.spage=8291&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi050253a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clostridium botulinum; Neurotoxins; Toxins; Apoenzymes; Immunogenicity; Structure-function relationships; Serotypes; Light chains; Biochemical analysis; Vaccines; Tetanus; Zinc; Mutation DO - http://dx.doi.org/10.1021/bi050253a ER - TY - JOUR T1 - Structural analysis of the catalytic domain of tetanus neurotoxin AN - 19957483; 6658931 AB - Clostridium neurotoxins, comprising the tetanus neurotoxin and the seven antigenically distinct botulinum neurotoxins (BoNT/A-G), are among the known most potent bacterial protein toxins to humans. Although they have similar function, sequences and three-dimensional structures, the substrate specificity and the selectivity of peptide bond cleavage are different and unique. Tetanus and botulinum type B neurotoxins enzymatically cleave the same substrate, vesicle-associated membrane protein, at the same peptide bond though the optimum length of substrate peptide required for cleavage by them is different. Here, we present the first experimentally determined three-dimensional structure of the catalytic domain of tetanus neurotoxin and analyze its active site. The structure provides insight into the active site of tetanus toxin's proteolytic activity and the importance of the nucleophilic water and the role of the zinc ion. The probable reason for different modes of binding of vesicle-associated membrane protein to botulinum neurotoxin type B and the tetanus toxin is discussed. The structure provides a basis for designing a novel recombinant vaccine or structure-based drugs for tetanus. JF - Toxicon AU - Rao, Krishnamurthy N AU - Kumaran, Desigan AU - Binz, Thomas AU - Swaminathan, Subramanyam AD - Brookhaven National Laboratory, Biology Department, 50 Bell Avenue, Upton, NY 11973, USA, swami@bnl.gov Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 929 EP - 939 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 45 IS - 7 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Clostridium neurotoxin KW - Tetanus neurotoxin KW - Botulinum neurotoxin KW - Zinc KW - Metalloprotease KW - Dual-wavelength anomalous diffraction (DAD) KW - X-ray structure KW - Proteolysis KW - Clostridium KW - Substrate specificity KW - Membrane proteins KW - tetanus toxin KW - Vaccines KW - Botulinum toxin KW - Neurotoxins KW - Tetanus KW - Drugs KW - X 24171:Microbial KW - N3 11028:Neuropharmacology & toxicology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19957483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Structural+analysis+of+the+catalytic+domain+of+tetanus+neurotoxin&rft.au=Rao%2C+Krishnamurthy+N%3BKumaran%2C+Desigan%3BBinz%2C+Thomas%3BSwaminathan%2C+Subramanyam&rft.aulast=Rao&rft.aufirst=Krishnamurthy&rft.date=2005-06-01&rft.volume=45&rft.issue=7&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2005.02.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Zinc; Substrate specificity; Botulinum toxin; Vaccines; tetanus toxin; Membrane proteins; Tetanus; Neurotoxins; Drugs; Clostridium DO - http://dx.doi.org/10.1016/j.toxicon.2005.02.032 ER - TY - JOUR T1 - Chemical evolution of an isolated power plant plume during the TexAQS 2000 study AN - 16200456; 6451621 AB - Stack emissions from a coal-burning power plant were measured during a research flight of the DOE G-1 during the Texas Air Quality Study (TexAQS 2000) on 10 September 2000. Clean upstream air and an isolated location allowed the plume to be unambiguously sampled during 12 successive downwind transects to a distance of 63 km; corresponding to a processing time of 4.6 h. The chemical transformation rates of sulfur and nitrogen primary pollutants into aerosol SO, and HNO, sub(3), yield independent values of OH concentration (8.0 and, 11x10, cm, super(-3), respectively) that are consistent within experimental uncertainty and qualitatively agree with constrained steady-state (CSS) box model calculations. Ozone production efficiency increases with plume age as expected. Primary aerosol emissions with, D sub(p)>5, , mu , m were sampled near the stack. As the plume ages, aerosol size distributions adjusted for dilution show constant number concentrations of aerosols, D sub(p)>10, nm and a marked increase in accumulation-mode particles (, D sub(p)>0.1, , mu , m) as gas-to-particle-conversion causes smaller particles to grow. JF - Atmospheric Environment AU - Springston AU - Kleinman, LI AU - Brechtel, F AU - Lee, Y-N AU - Nunnermacker, L J AU - Wang, J AD - Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 3431 EP - 3443 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 19 SN - 1352-2310, 1352-2310 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Power-plant plume KW - Texas 2000 Air Quality Study KW - Aerosol growth KW - Airborne measurements KW - Sulfur KW - Aerosols KW - Atmospheric pollution models KW - Sulfur in aerosols KW - Air quality KW - Particulates KW - Stack emissions KW - Plume models KW - Ozone production KW - Aerosol size distribution KW - Atmospheric chemistry KW - Power plants KW - Chemical transformation KW - USA, Texas KW - Plumes KW - Wind KW - Evolution KW - Nitrogen KW - Ozone KW - Plume dispersion KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16200456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Chemical+evolution+of+an+isolated+power+plant+plume+during+the+TexAQS+2000+study&rft.au=Springston%3BKleinman%2C+LI%3BBrechtel%2C+F%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BWang%2C+J&rft.aulast=Chen&rft.aufirst=J&rft.date=2005-12-01&rft.volume=86&rft.issue=52%2C+SUPPL.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Plume models; Ozone production; Sulfur in aerosols; Atmospheric pollution models; Aerosol size distribution; Atmospheric chemistry; Chemical transformation; Air quality; Evolution; Plume dispersion; Sulfur; Aerosols; Power plants; Particulates; Stack emissions; Plumes; Wind; Ozone; Nitrogen; USA, Texas DO - http://dx.doi.org/10.1016/j.atmosenv.2005.01.060 ER - TY - JOUR T1 - Long-Term Verification of Cover Systems Using Perfluorocarbon Tracers AN - 16188161; 6248807 AB - The expanded use of caps and cover systems is an important aspect of the U.S. Department of Energy Environmental Management's strategy for restoration and long-term stewardship of sites throughout the complex. However, very little is available in terms of long-term monitoring of covers other than downstream groundwater or surface water monitoring. A novel methodology for verifying and monitoring subsurface barriers and cover systems has been developed. Gaseous perfluorocarbon tracers (PFTs) are injected on one side of the barrier and searched for on the opposite side of the barrier. The capability for leak detection in subsurface barriers using PFTs has been proven at multiple demonstrations. Adaptation of this concept to covers is a necessary step prior to full-scale demonstration. This paper discusses the PFT technology and a successful proof-of-principle test of the PFT technology as a leak detection tool for cover verification and monitoring. JF - Journal of Environmental Engineering AU - Heiser, J AU - Sullivan, T AU - Serrato, M AD - Environmental Sciences Dept., Environmental Research and Technology Division, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA Y1 - 2005/06// PY - 2005 DA - Jun 2005 SP - 952 EP - 960 VL - 131 IS - 6 SN - 0733-9372, 0733-9372 KW - perfluorocarbons KW - subsurface KW - Pollution Abstracts KW - Environmental monitoring KW - Disposal sites KW - Tracers KW - Permeability KW - USA KW - Leak detection KW - Gases KW - Containment KW - Environment management KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16188161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Flow+banding+in+rhyolites%3B+a+manifestation+of+water+concentration+heterogeneity+in+the+melt%3F&rft.au=Seaman%2C+S+J%3BDyar%2C+D%3BMarinkovic%2C+N%3BAnonymous&rft.aulast=Levine&rft.aufirst=Kate&rft.date=2016-06-01&rft.volume=116&rft.issue=5&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Columbia+Law+Review&rft.issn=00101958&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-08-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Disposal sites; Environmental monitoring; Permeability; Tracers; Gases; Leak detection; Containment; Environment management; USA DO - http://dx.doi.org/10.1061/(ASCE)0733-9372(2005)131:6(952) ER - TY - JOUR T1 - Crystal Structure of the N-terminal Domain of the Group B Streptococcus Alpha C Protein AN - 17498386; 6274661 AB - Group B Streptococcus (GBS) is the leading cause of bacterial pneumonia, sepsis, and meningitis among neonates and an important cause of morbidity among pregnant women and immunocompromised adults. Invasive diseases due to GBS are attributed to the ability of the pathogen to translocate across human epithelial surfaces. The alpha C protein (ACP) has been identified as an invasin that plays a role in internalization and translocation of GBS across epithelial cells. The soluble N-terminal domain of ACP (NtACP) blocks the internalization of GBS. We determined the 1.86-Aa resolution crystal structure of NtACP comprising residues Ser super(52) through Leu super(225) of the full-length ACP. NtACP has two domains, an N-terminal beta -sandwich and a C-terminal three-helix bundle. Structural and topological alignments reveal that the beta -sandwich shares structural elements with the type III fibronectin fold (FnIII), but includes structural elaborations that make it unique. We have identified a potential integrin-binding motif consisting of Lys-Thr-Asp super(146), Arg super(110), and Asp super(118). A similar arrangement of charged residues has been described in other invasins. ACP shows a heparin binding activity that requires NtACP. We propose a possible heparin-binding site, including one surface of the three-helix bundle, and nearby portions of the sandwich and repeat domains. We have validated this prediction using assays of the heparin binding and cell-adhesion properties of engineered fragments of ACP. This is the first crystal structure of a member of the highly conserved Gram-positive surface alpha-like protein family, and it will enable the internalization mechanism of GBS to be dissected at the atomic level. JF - Journal of Biological Chemistry AU - Auperin, Thierry C AU - Bolduc, Gilles R AU - Baron, Miriam J AU - Heroux, Annie AU - Filman, David J AU - Madoff, Lawrence C AU - Hogle, James M AD - Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, the Brigham and Women's Hospital, Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, and the Biology Department, 463, Brookhaven National Laboratory, Upton, New York 11973-5000 Y1 - 2005/05/06/ PY - 2005 DA - 2005 May 06 SP - 18245 EP - 18252 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 18 SN - 0021-9258, 0021-9258 KW - streptococci KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Epithelial cells KW - Fibronectin KW - protein families KW - Pathogens KW - Morbidity KW - Meningitis KW - Sepsis KW - Crystal structure KW - double prime C protein KW - Neonates KW - Translocation KW - Heparin KW - Pneumonia KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17498386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Crystal+Structure+of+the+N-terminal+Domain+of+the+Group+B+Streptococcus+Alpha+C+Protein&rft.au=Auperin%2C+Thierry+C%3BBolduc%2C+Gilles+R%3BBaron%2C+Miriam+J%3BHeroux%2C+Annie%3BFilman%2C+David+J%3BMadoff%2C+Lawrence+C%3BHogle%2C+James+M&rft.aulast=Auperin&rft.aufirst=Thierry&rft.date=2005-05-06&rft.volume=280&rft.issue=18&rft.spage=18245&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Fibronectin; protein families; Pathogens; Morbidity; Meningitis; Sepsis; Crystal structure; double prime C protein; Neonates; Heparin; Translocation; Pneumonia; Streptococcus ER - TY - JOUR T1 - Health physics challenges involved with opening a "seventeen-inch" concrete waste vault. AN - 67734344; 15824590 AB - This paper describes the various activities involved with opening a sealed legacy "Seventeen-inch" concrete vault and the health physics challenges and solutions employed. As part of a legacy waste stream that was removed from the former Hazardous Waste Management Facility at Brookhaven National Laboratory, the "Seventeen-inch" concrete vault labeled 1-95 was moved to the new Waste Management Facility for ultimate disposal. Because the vault contained 239Pu foils with a total activity in excess of the transuranic waste limits, the foils needed to be removed and repackaged for disposal. Conventional diamond wire saws could not be used because of facility constraints, so this project relied mainly on manual techniques. The planning and engineering controls put in place enabled personnel to open the vault and remove the waste while keeping dose as low as reasonably achievable. JF - Health physics AU - Sullivan, Patrick T AU - Pizzulli, Michelle AD - Radiological Control Division, Brookhaven National Laboratory, PO Box 5000, Building 860, Upton, NY 11973, USA. sulli@bnl.gov Y1 - 2005/05// PY - 2005 DA - May 2005 SP - S97 EP - S103 VL - 88 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Radioactive Waste KW - 0 KW - Index Medicus KW - United States KW - Environmental Pollution -- prevention & control KW - Radiation Dosage KW - Risk Factors KW - Equipment Failure Analysis -- methods KW - Risk Assessment -- standards KW - Risk Assessment -- methods KW - Radiation Monitoring -- methods KW - Safety Management -- standards KW - Radioactive Waste -- prevention & control KW - Radiation Protection -- instrumentation KW - Radiation Protection -- standards KW - Decontamination -- methods KW - Radiation Monitoring -- standards KW - Radiation Protection -- methods KW - Decontamination -- instrumentation KW - Safety Management -- methods KW - Waste Management -- instrumentation KW - Health Physics -- methods KW - Health Physics -- instrumentation KW - Waste Management -- methods KW - Waste Management -- standards KW - Decontamination -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67734344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Health+physics+challenges+involved+with+opening+a+%22seventeen-inch%22+concrete+waste+vault.&rft.au=Sullivan%2C+Patrick+T%3BPizzulli%2C+Michelle&rft.aulast=Sullivan&rft.aufirst=Patrick&rft.date=2005-05-01&rft.volume=88&rft.issue=5+Suppl&rft.spage=S97&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-10 N1 - Date created - 2005-04-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Temperature-resolved synchrotron X-ray diffraction study of dehydration of birnessite-like phases AN - 51613077; 2006-024323 JF - Geochimica et Cosmochimica Acta AU - Post, Jeffrey E AU - Heaney, P J AU - Hanson, J AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 627 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - mineral interlayer KW - experimental studies KW - X-ray diffraction data KW - crystal structure KW - Rietveld refinement KW - temperature KW - synchrotron radiation KW - laboratory studies KW - birnessite KW - oxides KW - cations KW - dehydration KW - synthesis KW - crystal chemistry KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51613077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Temperature-resolved+synchrotron+X-ray+diffraction+study+of+dehydration+of+birnessite-like+phases&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+P+J%3BHanson%2C+J%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - birnessite; cations; crystal chemistry; crystal structure; dehydration; experimental studies; laboratory studies; mineral interlayer; oxides; Rietveld refinement; synchrotron radiation; synthesis; temperature; X-ray diffraction data ER - TY - JOUR T1 - Speciation and surface complexation of As on hydrous ferric oxide in soils modified by in situ chemical fixation AN - 51610338; 2006-024301 JF - Geochimica et Cosmochimica Acta AU - Donahoe, R J AU - Yang, L AU - Lanzirotti, A AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 616 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - hydrates KW - iron oxides KW - X-ray diffraction data KW - complexing KW - iron KW - soil sampling KW - XANES spectra KW - synchrotron radiation KW - ferric iron KW - oxides KW - spectra KW - geochemistry KW - soils KW - toxic materials KW - fixation KW - experimental studies KW - herbicides KW - arsenic KW - soil treatment KW - pollution KW - X-ray spectra KW - sample preparation KW - soil pollution KW - metals KW - EXAFS data KW - pesticides KW - leaching KW - SEM data KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51610338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Speciation+and+surface+complexation+of+As+on+hydrous+ferric+oxide+in+soils+modified+by+in+situ+chemical+fixation&rft.au=Donahoe%2C+R+J%3BYang%2C+L%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Donahoe&rft.aufirst=R&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - arsenic; chemical fractionation; complexing; EXAFS data; experimental studies; ferric iron; fixation; geochemistry; herbicides; hydrates; iron; iron oxides; leaching; metals; oxides; pesticides; pollution; sample preparation; SEM data; soil pollution; soil sampling; soil treatment; soils; spectra; synchrotron radiation; toxic materials; X-ray diffraction data; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Transformation of arsenic species in solids and porewaters from Yellowknife Bay, NWT, Canada AN - 51609990; 2006-024302 JF - Geochimica et Cosmochimica Acta AU - Andrade, C F AU - Jamieson, H E AU - Walker, S R AU - Lanzirotti, A AU - Praharaj, T AU - Fortin, D AU - Anonymous Y1 - 2005/05// PY - 2005 DA - May 2005 SP - 616 PB - Pergamon, Oxford VL - 69 IS - 10, Suppl. SN - 0016-7037, 0016-7037 KW - Great Slave Lake KW - XANES spectra KW - Yellowknife Northwest Territories KW - sediments KW - X-ray fluorescence spectra KW - spectra KW - geochemistry KW - Eh KW - Yellowknife Bay KW - liquid phase KW - hydrology KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - geochemical cycle KW - solid phase KW - limnology KW - Canada KW - metals KW - lacustrine environment KW - Western Canada KW - seasonal variations KW - transformations KW - aquatic environment KW - pore water KW - microorganisms KW - lake sediments KW - chemical fractionation KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51609990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Transformation+of+arsenic+species+in+solids+and+porewaters+from+Yellowknife+Bay%2C+NWT%2C+Canada&rft.au=Andrade%2C+C+F%3BJamieson%2C+H+E%3BWalker%2C+S+R%3BLanzirotti%2C+A%3BPraharaj%2C+T%3BFortin%2C+D%3BAnonymous&rft.aulast=Andrade&rft.aufirst=C&rft.date=2005-05-01&rft.volume=69&rft.issue=10%2C+Suppl.&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 15th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - aquatic environment; arsenic; Canada; chemical fractionation; Eh; geochemical cycle; geochemistry; Great Slave Lake; hydrology; lacustrine environment; lake sediments; limnology; liquid phase; metals; microorganisms; Northwest Territories; pollution; pore water; seasonal variations; sediments; solid phase; spectra; transformations; Western Canada; X-ray fluorescence spectra; X-ray spectra; XANES spectra; Yellowknife Bay; Yellowknife Northwest Territories ER - TY - JOUR T1 - N-terminal helix reorients in recombinant C-fragment of Clostridium botulinum type B. AN - 67529524; 15781237 AB - Botulinum neurotoxins comprise seven distinct serotypes (A-G) produced by Clostridium botulinum. The crystal structure of the binding domain of the botulinum neurotoxin type B (BBHc) has been determined to 2A resolution. The overall structure of BBHc is well ordered and similar to that of the binding domain of the holotoxin. However, significant structural changes occur at what would be the interface of translocation and binding domains of the holotoxin. The loop 911-924 shows a maximum displacement of 14.8A at the farthest point. The N-terminal helix reorients and moves by 19.5A from its original position. BBHc is compared with the binding domain of the holotoxin of botulinum type A and B, and the tetanus C-fragment to characterize the heavy chain-carbohydrate interactions. The probable reasons for different binding affinity of botulinum and tetanus toxins are discussed. JF - Biochemical and biophysical research communications AU - Jayaraman, Seetharaman AU - Eswaramoorthy, Subramaniam AU - Ahmed, S Ashraf AU - Smith, Leonard A AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2005/04/29/ PY - 2005 DA - 2005 Apr 29 SP - 97 EP - 103 VL - 330 IS - 1 SN - 0006-291X, 0006-291X KW - Carbohydrates KW - 0 KW - Recombinant Proteins KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Models, Molecular KW - Carbohydrates -- chemistry KW - Crystallography, X-Ray KW - Recombinant Proteins -- chemistry KW - Protein Conformation KW - Botulinum Toxins -- chemistry KW - Clostridium botulinum -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67529524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=N-terminal+helix+reorients+in+recombinant+C-fragment+of+Clostridium+botulinum+type+B.&rft.au=Jayaraman%2C+Seetharaman%3BEswaramoorthy%2C+Subramaniam%3BAhmed%2C+S+Ashraf%3BSmith%2C+Leonard+A%3BSwaminathan%2C+Subramanyam&rft.aulast=Jayaraman&rft.aufirst=Seetharaman&rft.date=2005-04-29&rft.volume=330&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-05-26 N1 - Date created - 2005-03-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Imaging addiction with PET: is insight in sight? AN - 67752038; 15837598 AB - Neurochemical imaging studies can identify molecular targets of abused drugs and link them to the underlying pathology associated with behaviors such as drug dependence, addiction and withdrawal. positron emission tomography (PET) is opening new avenues for the investigation of the neurochemical disturbances underlying drug abuse and addiction and the in vivo mechanisms by which medications might ameliorate these conditions. PET can identify vulnerable human populations, treatment strategies and monitor treatment efficacy. Thus, with this tool and the knowledge it provides, the potential for developing novel drugs and treatment strategies for drug addiction is now close at hand. JF - Drug discovery today AU - Schiffer, Wynne K AU - Lee, Dianne E AU - Brodie, Jonathan D AU - Dewey, Stephen L AD - Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY 11794, USA. wynne@bnl.gov Y1 - 2005/04/15/ PY - 2005 DA - 2005 Apr 15 SP - 547 EP - 562 VL - 10 IS - 8 SN - 1359-6446, 1359-6446 KW - Index Medicus KW - Animals KW - Humans KW - Forecasting KW - Terminology as Topic KW - Substance-Related Disorders -- diagnosis KW - Positron-Emission Tomography -- instrumentation KW - Positron-Emission Tomography -- utilization KW - Positron-Emission Tomography -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67752038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+discovery+today&rft.atitle=Imaging+addiction+with+PET%3A+is+insight+in+sight%3F&rft.au=Schiffer%2C+Wynne+K%3BLee%2C+Dianne+E%3BBrodie%2C+Jonathan+D%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2005-04-15&rft.volume=10&rft.issue=8&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-29 N1 - Date created - 2005-04-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Methylmercury, fish consumption, and the precautionary principle. AN - 67822943; 15887881 AB - This paper considers several broad issues in the context of probabilistic assessment of the benefits of curtailing mercury (Hg) emissions from U.S. coal-fired power plants, based on information developed from recent literature and epidemiology studies of health effects of methylmercury. Exposure of the U.S. population is considered on the national scale, in large part because of recent questions arising from survey and experimental data about the relative importance of local deposition of airborne Hg. Although epidemiological studies have provided useful information, safe levels of Hg exposure remain uncertain, in part because of other dietary considerations in the populations that were studied. For example, much of the seafood consumed in one of the major studies was also contaminated with polychlorinated biphenyls, as are fish taken from some U.S. fresh waters. The primary epidemiological approach involves cross-study comparisons in relation to mean exposures, rather than detailed critiques of individual effects reported in each study. U.S. exposures are seen to be well below the levels at which adverse health effects are reported. This analysis supports the conclusion that unilateral reduction of Hg emissions from U.S. coal-fired power plants alone is unlikely to realize significant public health benefits. JF - Journal of the Air & Waste Management Association (1995) AU - Lipfert, Fred AU - Morris, Sam AU - Sullivan, Terry AU - Moskowitz, Paul AU - Renninger, Scott AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 388 EP - 398 VL - 55 IS - 4 SN - 1096-2247, 1096-2247 KW - Coal KW - 0 KW - Methylmercury Compounds KW - Index Medicus KW - Animals KW - Incineration KW - Public Health KW - Air Pollution -- prevention & control KW - Power Plants KW - Humans KW - Fishes KW - Diet KW - Risk Assessment KW - Methylmercury Compounds -- poisoning KW - Food Contamination KW - Seafood KW - Methylmercury Compounds -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67822943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association+%281995%29&rft.atitle=Methylmercury%2C+fish+consumption%2C+and+the+precautionary+principle.&rft.au=Lipfert%2C+Fred%3BMorris%2C+Sam%3BSullivan%2C+Terry%3BMoskowitz%2C+Paul%3BRenninger%2C+Scott&rft.aulast=Lipfert&rft.aufirst=Fred&rft.date=2005-04-01&rft.volume=55&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association+%281995%29&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-06-03 N1 - Date created - 2005-05-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Multidomain synthetic peptide B2A2 synergistically enhances BMP-2 in vitro. AN - 67507987; 15765189 AB - UNLABELLEDA multidomain, synthetic peptide designated B2A2 synergizes the activity of BMP-2. B2A2 interacts with BMP receptor isoforms, potentiating the action of BMP-2 in activating alkaline phosphatase and triggering Smad and MAPK signaling. B2A2's design permits its delivery as a local surface coating as well as a soluble co-factor, thus broadening potential bioengineering applications.INTRODUCTIONBMP-2 induces osteogenic differentiation and accelerates bone repair. Although BMP-2 inhibitors have been discovered, no BMP-2 mimetics or enhancers that function in the physiological range have yet been found. Here we report that a synthetic peptide designated B2A2, consisting of (1) a BMP receptor-targeting sequence, (2) a hydrophobic spacer, and (3) a heparin-binding sequence, is a positive modulator of recombinant BMP-2.MATERIALS AND METHODSCultures of mesenchymal cell lines C2C12 and C3H10T1/2 were given B2A2, recombinant BMP-2, or both. Alkaline phosphatase (ALP) activity was assayed by conversion of paranitrophenol phosphate (PNPP). Signaling through Smad and MAP kinase pathways was monitored by Western blot. Receptor binding was assessed by incubating immobilized B2A2 with soluble recombinant receptor-Fc chimeras and detecting bound receptor by anti-Fc antibody ELISA. Surface coating of medical device materials was done by first dip-coating with silyl-heparin, followed by B2A2.RESULTS AND CONCLUSIONSTreatment of cells with B2A2 alone marginally increased ALP activity. However, B2A2 plus BMP-2 resulted in 5- to 40-fold augmentation of ALP compared with BMP-2 alone in C3H10T1/2 or C2C12 cells, respectively. This synergistic enhancement was observed over a broad concentration range (4-1000 ng/ml BMP-2). B2A2 interacted directly with BMP receptor isoforms (preferentially to BMPR-Ib and ActivinR-II). In cells, B2A2 + BMP-2 led to a repression of MAP kinase and an increase of Smad activation, consistent with known activation pathways of BMP-2. B2A2 was ineffective when paired with other cytokine/growth factors (basic fibroblast growth factor [FGF-2], TGF-beta1, vascular endothelial growth factor [VEGF]). Simultaneous co-administration was not strictly required. Pulse-chase experiments revealed that temporal separations up to 1 h were still effective. B2A2 was also effective when delivered in a polystyrene- or stainless steel-coated surface through a heparin platform (silyl-heparin) while BMP-2 was added exogenously in solution. These results suggest that B2A2 might promote aggregation of receptor subunits, enabling BMP-2 to activate signaling pathways at effectively lower concentrations. Synthetic multidomain constructs like B2A2 may be useful to accelerate bone repair/deposition through augmentation of endogenous levels of BMP-2 or through local BMP-2 contained in artificial or engineered matrices. JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research AU - Lin, Xinhua AU - Zamora, Paul O AU - Albright, Sarah AU - Glass, John D AU - Peña, Louis A AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 693 EP - 703 VL - 20 IS - 4 SN - 0884-0431, 0884-0431 KW - B2A2 peptide KW - 0 KW - BMP2 protein, human KW - Bmp2 protein, mouse KW - Bone Morphogenetic Protein 2 KW - Bone Morphogenetic Proteins KW - Peptides KW - Protein Isoforms KW - Transforming Growth Factor beta KW - Mitogen-Activated Protein Kinase 3 KW - EC 2.7.11.24 KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Index Medicus KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Animals KW - Down-Regulation KW - Cells, Cultured KW - Humans KW - Mice KW - Alkaline Phosphatase -- metabolism KW - Protein Isoforms -- pharmacology KW - Drug Synergism KW - Cricetinae KW - Transforming Growth Factor beta -- pharmacology KW - Bone Morphogenetic Proteins -- pharmacology KW - Peptides -- chemistry KW - Peptides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67507987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.atitle=Multidomain+synthetic+peptide+B2A2+synergistically+enhances+BMP-2+in+vitro.&rft.au=Lin%2C+Xinhua%3BZamora%2C+Paul+O%3BAlbright%2C+Sarah%3BGlass%2C+John+D%3BPe%C3%B1a%2C+Louis+A&rft.aulast=Lin&rft.aufirst=Xinhua&rft.date=2005-04-01&rft.volume=20&rft.issue=4&rft.spage=693&rft.isbn=&rft.btitle=&rft.title=Journal+of+bone+and+mineral+research+%3A+the+official+journal+of+the+American+Society+for+Bone+and+Mineral+Research&rft.issn=08840431&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-03-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Soil manganese oxides and trace metals; competitive sorption and microfocused synchrotron-X-ray fluorescence mapping AN - 51614633; 2006-027325 AB - Trace metal accumulation by Mn in synthetic oxides and soil nodules has been attributed to specific adsorption and oxidation at Mn oxide surfaces, yet little is known about trace metal interactions with Mn in bulk soil. We investigated competitive effects of trace metal pretreatment on Cr oxidation in well-aerated, high-Mn soils, as well as accumulation of added Pb, Co, and Cu by soil Mn using microfocused synchrotron x-ray fluorescence (mu SXRF). Short-term equilibrations of divalent Mn, Co, Pb, Cu, and Ni with soil samples weighed to contain equivalent amounts of NH (sub 2) OH.HCl-extractable Mn resulted in substantial interference in Cr oxidation, confirming metal interactions with Cr-oxidizing sites on Mn oxide surfaces. Interference by Cu and Pb was greatest in samples likely to be low in competing sorbents, that is, low-pH soils and smaller samples of higher Mn soils, respectively. Strongest interference in Cr oxidation resulted from Mn and Co addition, suggesting specific affinity for soil Mn oxide surfaces, and was greatest in high-pH, high-Mn-valence soils previously shown to have the greatest Cr oxidation capacity. Nickel showed the weakest effect. Micro-SXRF scans revealed substantial spatial correlation of soil Mn with added Co and Pb, but Pb microdistribution was equally correlated with soil Fe. Only modest overlap of soil Mn with added Cu was observed. Our data suggest that specific affinity of Pb, Cu, and Ni for soil Mn oxides was weaker than that of Mn and Co. Higher Mn oxide valence may enhance sorption and subsequent oxidation of these oxidizable metals. JF - Soil Science Society of America Journal (Internet) AU - Negra, Christine AU - Ross, Donald S AU - Lanzirotti, Antonio Y1 - 2005/04// PY - 2005 DA - April 2005 SP - 353 EP - 361 PB - Soil Science Society of America, Madison, WI VL - 69 IS - 2 SN - 0361-5995, 0361-5995 KW - United States KW - sorption KW - secondary structures KW - cobalt KW - copper KW - lead KW - mapping KW - manganese KW - spatial distribution KW - Eutrudepts KW - northwestern Vermont KW - chemical reactions KW - manganese oxides KW - X-ray analysis KW - oxides KW - applications KW - valency KW - sedimentary structures KW - geochemistry KW - synthetic materials KW - pH KW - chromium KW - soils KW - chemical analysis KW - X-ray fluorescence KW - oxidation KW - Vermont KW - concretions KW - Inceptisols KW - metals KW - X-ray spectroscopy KW - nickel KW - synchrotrons KW - trace metals KW - spectroscopy KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51614633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal+%28Internet%29&rft.atitle=Soil+manganese+oxides+and+trace+metals%3B+competitive+sorption+and+microfocused+synchrotron-X-ray+fluorescence+mapping&rft.au=Negra%2C+Christine%3BRoss%2C+Donald+S%3BLanzirotti%2C+Antonio&rft.aulast=Negra&rft.aufirst=Christine&rft.date=2005-04-01&rft.volume=69&rft.issue=2&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal+%28Internet%29&rft.issn=03615995&rft_id=info:doi/ L2 - http://soil.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 48 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - SuppNotes - Accessed on March 21, 2005 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - applications; chemical analysis; chemical reactions; chromium; cobalt; concretions; copper; Eutrudepts; geochemistry; Inceptisols; lead; manganese; manganese oxides; mapping; metals; nickel; northwestern Vermont; oxidation; oxides; pH; secondary structures; sedimentary structures; soils; sorption; spatial distribution; spectroscopy; synchrotrons; synthetic materials; trace metals; United States; valency; Vermont; X-ray analysis; X-ray fluorescence; X-ray spectroscopy ER - TY - JOUR T1 - The crystal structures of synthetics Fe (sub 2) (SO (sub 4) ) (sub 3) (H (sub 2) O) (sub 5) and the type specimen of lausenite AN - 51722925; 2005-030915 AB - An iron sulphate of nominal composition Fe (sub 2) (SO (sub 4) ) (sub 3) (H (sub 2) O) (sub 5 ) was synthesized and its structure determined and refined by high-resolution synchrotron powder XRD. The structure consists of corrugated slabs in which iron octahedra are linked by sulphate tetrahedra in the monoclinic space group P2 (sub 1) /m, with a 10.711, b 11.085, c 5.5747 Aa, beta 98.853 degrees , V 654.0 Aa (super 3) , Z = 2. These results are compared with those for the type specimen of lausenite from Jerome, Arizona, which has a 10.679, b 11.053, c 5.567 Aa, beta 98.89 degrees . TG and DTA curves show that it is a pentahydrate, despite earlier reports that lausenite is a hexahydrate. It is considered that the synthetic material provides a structure determination for lausenite. JF - American Mineralogist AU - Majzlan, Juraj AU - Botez, Cristian AU - Stephens, Peter W Y1 - 2005/03// PY - 2005 DA - March 2005 SP - 411 EP - 416 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 2-3 SN - 0003-004X, 0003-004X KW - United States KW - hydrates KW - Yavapai County Arizona KW - X-ray diffraction data KW - thermogravimetric analysis KW - sulfates KW - crystal systems KW - crystal structure KW - powder method KW - Jerome Arizona KW - iron KW - synchrotron radiation KW - metals KW - lausenite KW - Arizona KW - monoclinic system KW - lattice parameters KW - DTA data KW - crystallography KW - TGA data KW - synthetic materials KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51722925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=The+crystal+structures+of+synthetics+Fe+%28sub+2%29+%28SO+%28sub+4%29+%29+%28sub+3%29+%28H+%28sub+2%29+O%29+%28sub+5%29+and+the+type+specimen+of+lausenite&rft.au=Majzlan%2C+Juraj%3BBotez%2C+Cristian%3BStephens%2C+Peter+W&rft.aulast=Majzlan&rft.aufirst=Juraj&rft.date=2005-03-01&rft.volume=90&rft.issue=2-3&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2005.1701 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2005-01-01 N1 - Number of references - 17 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - Arizona; crystal structure; crystal systems; crystallography; DTA data; hydrates; iron; Jerome Arizona; lattice parameters; lausenite; metals; monoclinic system; powder method; sulfates; synchrotron radiation; synthetic materials; TGA data; thermogravimetric analysis; United States; X-ray diffraction data; Yavapai County Arizona DO - http://dx.doi.org/10.2138/am.2005.1701 ER - TY - JOUR T1 - Crystal Structures of the BlaI Repressor from Staphylococcus aureus and Its Complex with DNA: Insights into Transcriptional Regulation of the bla and mec Operons AN - 17835300; 6169447 AB - The 14-kDa BlaI protein represses the transcription of blaZ, the gene encoding beta -lactamase. It is homologous to MecI, which regulates the expression of mecA, the gene encoding the penicillin binding protein PBP2a. These genes mediate resistance to beta -lactam antibiotics in staphylococci. Both repressors can bind either bla or mec DNA promoter-operator sequences. Regulated resistance genes are activated via receptor-mediated cleavage of the repressors. Cleavage is induced when beta -lactam antibiotics bind the extramembrane sensor of the sensor-transducer signaling molecules, BlaR1 or MecR1. The crystal structures of BlaI from Staphylococcus aureus, both in free form and in complex with 32 bp of DNA of the mec operator, have been determined to 2.0-and 2.7-Aa resolutions, respectively. The structure of MecI, also in free form and in complex with the bla operator, has been previously reported. Both repressors form homodimers, with each monomer composed of an N-terminal DNA binding domain of winged helix-turn-helix topology and a C- terminal dimerization domain. The structure of BlaI in complex with the mec operator shows a protein-DNA interface that is conserved between both mec and bla targets. The recognition helix alpha 3 interacts specifically with the conserved TACA/TGTA DNA binding motif. BlaI and, probably, MecI dimers bind to opposite faces of the mec DNA double helix in an up-and-down arrangement, whereas MecI and, probably, BlaI dimers bind to the same DNA face of bla promoter-operator DNA. This is due to the different spacing of mec and bla DNA binding sites. Furthermore, the flexibility of the dimeric proteins may make the C-terminal proteolytic cleavage site more accessible when the repressors are bound to DNA than when they are in solution, suggesting that the induction cascade involves bound rather than free repressor. JF - Journal of Bacteriology AU - Safo, Martin K AU - Zhao, Qixun AU - Ko, Tzu-Ping AU - Musayev, Faik N AU - Robinson, Howard AU - Scarsdale, Neel AU - Wang, Andrew H-J AU - Archer, Gordon L AD - Department of Medicinal Chemistry, School of Pharmacy and Institute for Structural Biology and Drug Discovery. Departments of Medicine and Microbiology/Immunology, Virginia Commonwealth University, Richmond, Virginia. Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei, Taiwan. Department of Biology, Brookhaven National Laboratory, Upton, New York Y1 - 2005/03/01/ PY - 2005 DA - 2005 Mar 01 SP - 1833 EP - 1844 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 5 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Proteolysis KW - Nucleotide sequence KW - Antibiotics KW - Operators KW - Crystal structure KW - Staphylococcus aureus KW - b-Lactam antibiotics KW - Transcription KW - Penicillin KW - ^b-Lactam antibiotics KW - Gene regulation KW - DNA KW - Operons KW - Repressors KW - BlaI protein KW - Signal transduction KW - J 02725:DNA KW - N 14045:Transcriptional regulation KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17835300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Crystal+Structures+of+the+BlaI+Repressor+from+Staphylococcus+aureus+and+Its+Complex+with+DNA%3A+Insights+into+Transcriptional+Regulation+of+the+bla+and+mec+Operons&rft.au=Safo%2C+Martin+K%3BZhao%2C+Qixun%3BKo%2C+Tzu-Ping%3BMusayev%2C+Faik+N%3BRobinson%2C+Howard%3BScarsdale%2C+Neel%3BWang%2C+Andrew+H-J%3BArcher%2C+Gordon+L&rft.aulast=Safo&rft.aufirst=Martin&rft.date=2005-03-01&rft.volume=187&rft.issue=5&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; DNA; Repressors; Transcription; Operators; Crystal structure; Antibiotics; Gene regulation; b-Lactam antibiotics; Proteolysis; BlaI protein; Signal transduction; Nucleotide sequence; Operons; Penicillin; ^b-Lactam antibiotics ER - TY - JOUR T1 - Oxidizing behavior of soil manganese; interactions among abundance, oxidation state, and pH AN - 51752211; 2005-015456 AB - Due to their high degree of reactivity, Mn oxides in soil systems may exert a greater influence on trace metal chemistry than that suggested by their relatively low abundance. In particular, Mn is the only known oxidizer of trivalent Cr in soils. We investigated soil properties that influence the Cr oxidizing capacity of Mn oxides in eight well-aerated high Mn soils. Total and easily reducible Mn abundance were quantified by extraction with 1.5 M NH (sub 2) OH degrees HCl and 0.02 M hydroquinone. Relativeaverage Mn oxidation state in soil samples was determined by x-ray absorption near edge structure spectroscopy (Mn-XANES) main edge energy position. Soils ranged in percentage of NH (sub 2) OH.HCl-extractable Mn between 0.14 and 1.27, pH between 4.4 and 7.2, and percentage of C between 9.0 and 27.2. Manganese-XANES spectra showed that most of the study soils had a high Mn(IV)/Mn(III) ratio with edge energy position intermediate to that of a synthetic birnessite and a synthetic pyrolusite. In these high Mn soils, Mn-XANES edge energy was positively correlated with soil pH, suggesting a linear increase, over the normal range of soil pH, in the Mn(IV)/Mn(III) ratio of soil oxides. Soils with more total reducible Mn generally demonstrated greater net Cr(VI) production, but this pattern was moderated by soil pH and relative Mn oxidation state. High Mn soils with low pH and Mn oxidation state were weaker Cr oxidizers than their Mn abundance would suggest. Our data provide evidence that greater Mn abundance and greater Mn(IV)/Mn(III) ratio in soil Mn oxides enhances Cr oxidation. JF - Soil Science Society of America Journal AU - Negra, Christine AU - Ross, Donald S AU - Lanzirotti, Antonio Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 87 EP - 95 PB - Soil Science Society of America, Madison, WI VL - 69 IS - 1 SN - 0361-5995, 0361-5995 KW - United States KW - soils KW - experimental studies KW - oxidation KW - manganese KW - X-ray spectra KW - Vermont KW - XANES spectra KW - Eutrudepts KW - northwestern Vermont KW - Inceptisols KW - chemical reactions KW - quantitative analysis KW - metals KW - manganese oxides KW - oxides KW - spectra KW - geochemistry KW - pH KW - Eh KW - chromium KW - 02C:Geochemistry of rocks, soils, and sediments KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51752211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Science+Society+of+America+Journal&rft.atitle=Oxidizing+behavior+of+soil+manganese%3B+interactions+among+abundance%2C+oxidation+state%2C+and+pH&rft.au=Negra%2C+Christine%3BRoss%2C+Donald+S%3BLanzirotti%2C+Antonio&rft.aulast=Negra&rft.aufirst=Christine&rft.date=2005-02-01&rft.volume=69&rft.issue=1&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Soil+Science+Society+of+America+Journal&rft.issn=03615995&rft_id=info:doi/ L2 - http://soil.scijournals.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 56 N1 - PubXState - WI N1 - Document feature - illus. incl. 3 tables N1 - SuppNotes - Accessed on February 2, 2005 N1 - Last updated - 2012-06-07 N1 - CODEN - SSSJD4 N1 - SubjectsTermNotLitGenreText - chemical reactions; chromium; Eh; Eutrudepts; experimental studies; geochemistry; Inceptisols; manganese; manganese oxides; metals; northwestern Vermont; oxidation; oxides; pH; quantitative analysis; soils; spectra; United States; Vermont; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Internal structure of type I deep-sea spherules by X-ray computed microtomography AN - 51691270; 2005-049748 AB - The internal structures of type I spherules (melted micrometeorites rich in iron) have been investigated using synchrotron-based computed microtomography. Variations from sphericity are small--the average ratio of the largest to the smallest semimajor axis is 1.07+ or -0.06. The X-ray tomographs reveal interior cavities, four spherules with metal cores with diameters ranging from 57 to 143 mu m and, in two spherules, high attenuation features thought to be nuggets rich in platinum-group elements. Bulk densities range from 4.2 to 5.9 g/cm (super 3) and average grain densities from 4.5 to 6.5 (g/cm (super 3) ) with uncertainties of 10-15%. The average grain densities are those expected for materials containing mostly oxides of iron and nickel. The tomographic density measurements indicate an average void space of 5 (super +8) (sub -5) %. The void spaces may be contraction features or the skeletons of bubbles that formed in the molten precursors during atmospheric passage. JF - Meteoritics & Planetary Science AU - Feng, H AU - Jones, K W AU - Tomov, S AU - Stewart, B AU - Herzog, G F AU - Schnabel, C AU - Brownlee, D E Y1 - 2005/02// PY - 2005 DA - February 2005 SP - 195 EP - 206 PB - Meteoritical Society, Fayetteville, AR VL - 40 IS - 2 SN - 1086-9379, 1086-9379 KW - tomography KW - nuggets KW - iron oxides KW - density KW - iron-rich composition KW - deep-sea environment KW - platinum group KW - melts KW - iridium KW - synchrotron radiation KW - mass KW - meteorites KW - hematite KW - Pacific Basin KW - X-ray analysis KW - oxides KW - dimensions KW - spectra KW - wustite KW - spherules KW - bulk density KW - bubbles KW - X-ray spectra KW - porosity KW - micrometeorites KW - physical properties KW - contraction KW - computed tomography KW - microscope methods KW - metals KW - marine environment KW - Pacific Ocean KW - volume KW - scanning electron microscopy KW - magnetite KW - 05B:Petrology of meteorites and tektites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51691270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meteoritics+%26+Planetary+Science&rft.atitle=Internal+structure+of+type+I+deep-sea+spherules+by+X-ray+computed+microtomography&rft.au=Feng%2C+H%3BJones%2C+K+W%3BTomov%2C+S%3BStewart%2C+B%3BHerzog%2C+G+F%3BSchnabel%2C+C%3BBrownlee%2C+D+E&rft.aulast=Feng&rft.aufirst=H&rft.date=2005-02-01&rft.volume=40&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Meteoritics+%26+Planetary+Science&rft.issn=10869379&rft_id=info:doi/ L2 - http://cavern.uark.edu/~meteor/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 36 N1 - PubXState - AR N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - MERTAW N1 - SubjectsTermNotLitGenreText - bubbles; bulk density; computed tomography; contraction; deep-sea environment; density; dimensions; hematite; iridium; iron oxides; iron-rich composition; magnetite; marine environment; mass; melts; metals; meteorites; micrometeorites; microscope methods; nuggets; oxides; Pacific Basin; Pacific Ocean; physical properties; platinum group; porosity; scanning electron microscopy; spectra; spherules; synchrotron radiation; tomography; volume; wustite; X-ray analysis; X-ray spectra ER - TY - JOUR T1 - LcrV Capture Enzyme-Linked Immunosorbent Assay for Detection of Yersinia pestis from Human Samples AN - 17774421; 6167137 AB - In the United States, there is currently a major gap in the diagnostic capabilities with regard to plague. To address this, we developed an antigen capture assay using an essential virulence factor secreted by Yersinia spp., LcrV, as the target antigen. We generated anti-LcrV monoclonal antibodies (MAbs) and screened them for the ability to bind bacterially secreted native Yersinia pestis LcrV. Anti-LcrV MAb 19.31 was used as a capture antibody, and biotinylated MAb 40.1 was used for detection. The detection limit of this highly sensitive Yersinia LcrV capture enzyme-linked immunosorbent assay is 0.1 ng/ml. The assay detected LcrV from human sputum and blood samples treated with concentrations as low as 0.5 ng/ml of bacterially secreted native Y. pestis LcrV. This assay could be used as a tool to help confirm the diagnosis of plague in patients presenting with pneumonia. JF - Clinical and Diagnostic Laboratory Immunology AU - Gomes-Solecki, Maria JC AU - Savitt, Anne G AU - Rowehl, Rebecca AU - Glass, John D AU - Bliska, James B AU - Dattwyler, Raymond J AD - Center for Infectious Diseases. Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook. Brookhaven National Laboratory, Upton, New York Y1 - 2005/02// PY - 2005 DA - Feb 2005 SP - 339 EP - 346 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 12 IS - 2 SN - 1071-412X, 1071-412X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - virulence factors KW - Monoclonal antibodies KW - LcrV protein KW - Yersinia pestis KW - Sputum KW - Plague KW - Pneumonia KW - J 02831:Techniques and reagents KW - F 06720:ELISA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17774421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Diagnostic+Laboratory+Immunology&rft.atitle=LcrV+Capture+Enzyme-Linked+Immunosorbent+Assay+for+Detection+of+Yersinia+pestis+from+Human+Samples&rft.au=Gomes-Solecki%2C+Maria+JC%3BSavitt%2C+Anne+G%3BRowehl%2C+Rebecca%3BGlass%2C+John+D%3BBliska%2C+James+B%3BDattwyler%2C+Raymond+J&rft.aulast=Gomes-Solecki&rft.aufirst=Maria&rft.date=2005-02-01&rft.volume=12&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Diagnostic+Laboratory+Immunology&rft.issn=1071412X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Yersinia pestis; LcrV protein; Monoclonal antibodies; Enzyme-linked immunosorbent assay; Plague; Pneumonia; virulence factors; Sputum ER - TY - JOUR T1 - Anger and depression in cocaine addiction: association with the orbitofrontal cortex. AN - 67427296; 15708297 AB - The high prevalence of anger, impulsivity and violence in cocaine addiction implicates chronic cocaine use in the compromise of higher-order inhibitory control neurocognitive processes. We used the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) anger content scale as a personality measure of inhibitory control and examined its association with glucose metabolism in the lateral orbitofrontal gyrus (LOFG) at rest as measured by positron emission tomography with 2-deoxy-2[(18)F]fluoro-D-glucose (PET (18)FDG) in 17 recently abstinent cocaine-dependent subjects and 16 comparison subjects. Three additional variables--the MMPI-2 depression content scale, metabolism in the medial orbitofrontal gyrus (MOFG) and the anterior cingulate (AC) gyrus--were inspected. When level of education was statistically controlled for, the LOFG was significantly associated with anger within the cocaine group. No other region was associated with anger within the cocaine-dependent group, and the LOFG did not correlate with depression within any of the study groups. The present study confirms earlier reports in demonstrating a positive association between relative metabolism at rest in the LOFG and cognitive-behavioral and personality measures of inhibitory control in drug addiction: the higher the metabolism, the better the inhibitory control. JF - Psychiatry research AU - Goldstein, Rita Z AU - Alia-Klein, Nelly AU - Leskovjan, Andreana C AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Gur, Ruben C AU - Hitzemann, Robert AU - Volkow, Nora D AD - Medical Research, Brookhaven National Laboratory, Bldg. 490, 30 Bell Ave, Upton, NY, 11973-5000, USA. rgoldstein@bnl.gov Y1 - 2005/01/30/ PY - 2005 DA - 2005 Jan 30 SP - 13 EP - 22 VL - 138 IS - 1 SN - 0165-1781, 0165-1781 KW - Radiopharmaceuticals KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Severity of Illness Index KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- metabolism KW - Positron-Emission Tomography KW - Cognition Disorders -- epidemiology KW - Mental Disorders -- epidemiology KW - Glucose -- metabolism KW - Gyrus Cinguli -- diagnostic imaging KW - Humans KW - Personality Disorders -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- metabolism KW - Mental Disorders -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Personality Disorders -- epidemiology KW - Personality Disorders -- diagnosis KW - Mental Disorders -- diagnosis KW - MMPI KW - Adult KW - Gyrus Cinguli -- metabolism KW - Chronic Disease KW - Inhibition (Psychology) KW - Prefrontal Cortex -- diagnostic imaging KW - Prefrontal Cortex -- metabolism KW - Depression -- metabolism KW - Depression -- epidemiology KW - Cocaine-Related Disorders -- epidemiology KW - Cocaine-Related Disorders -- metabolism KW - Anger UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67427296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Anger+and+depression+in+cocaine+addiction%3A+association+with+the+orbitofrontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BAlia-Klein%2C+Nelly%3BLeskovjan%2C+Andreana+C%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BGur%2C+Ruben+C%3BHitzemann%2C+Robert%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2005-01-30&rft.volume=138&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-26 N1 - Date created - 2005-02-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - PET imaging in clinical drug abuse research. AN - 68736070; 16250850 AB - Over the last two decades, SPECT (single photon emission computed tomography) and especially PET (positron emission tomography) have proven increasingly effective imaging modalities in the study of human psychopharmacology. Abusing populations can be studied at multiple times after abstinence begins, to give information about neurochemical and physiological adaptations of the brain during recovery from addiction. Individual human subjects can be studied using multiple positron labeled radiotracers, so as to probe more than one facet of brain function. PET and SPECT have been used to help our understanding of many aspects of the pharmacokinetics and pharmacodynamics of abused drugs, and have made valuable contributions in terms of drug mechanisms, drug interactions (e.g. cocaine and alcohol) and drug toxicities. They have also been employed to study the acute effects of drugs on populations of active drug abusers and of normal controls, and to evaluate the neurochemical consequences of candidate therapies for drug abuse. A particularly productive strategy has been the use of PET in conjunction with neuropsychological testing of subjects, to allow correlation of imaging data with uniquely human aspects of the effects of drugs, such as euphoria and craving. JF - Current pharmaceutical design AU - Gatley, S John AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Logan, Jean AU - Ding, Yu-Shin AU - Gerasimov, Madina AD - Center for Translational Neuroimaging, Brookhaven National Laboratory, Upton, NY 11973, USA. gatley@neu.edu Y1 - 2005 PY - 2005 DA - 2005 SP - 3203 EP - 3219 VL - 11 IS - 25 SN - 1381-6128, 1381-6128 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Morphine Dependence -- diagnostic imaging KW - Alcoholism -- diagnostic imaging KW - Tobacco Use Disorder -- diagnostic imaging KW - Nicotine -- metabolism KW - Humans KW - Cocaine-Related Disorders -- diagnostic imaging KW - Tomography, Emission-Computed, Single-Photon KW - Positron-Emission Tomography KW - Brain -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68736070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+pharmaceutical+design&rft.atitle=PET+imaging+in+clinical+drug+abuse+research.&rft.au=Gatley%2C+S+John%3BVolkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BDing%2C+Yu-Shin%3BGerasimov%2C+Madina&rft.aulast=Gatley&rft.aufirst=S&rft.date=2005-01-01&rft.volume=11&rft.issue=25&rft.spage=3203&rft.isbn=&rft.btitle=&rft.title=Current+pharmaceutical+design&rft.issn=13816128&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - 241Am, 137Cs, Sr and Pb uptake by tobacco as influenced by application of Fe chelators to soil. AN - 67742545; 15829335 AB - To determine the potential for phytoextraction of 241Am and other contaminants from soil, accumulation of 241Am, 137Cs, Sr, Fe, Al, Pb, and Mg by tobacco was determined for soil applications of two concentrations of ethylenediaminetetraacetic acid (EDTA), citric acid, and ascorbic acid. In tobacco receiving EDTA at 3.1 mmol/kg of soil, 241Am content of plants averaged 15 Bq/kg (ranging up to 26 Bq/kg) while Fe concentrations became constant at 4.5 mmol/kg. Soil treatment with 18.8 mmol/kg EDTA resulted in average 241Am concentrations of 29 Bq/kg (19 times higher than controls). Uptake of Pb was similar to 241Am. In these samples, Fe increased to a maximum of almost 18 mmol/kg and 241Am content increased linearly with both Fe and Al. Plants receiving ascorbic and citric acids took up smaller quantities of 241Am, Pb, and Fe, even though these reagents were able to elute about as much Fe from the soil as EDTA. Synchrotron microbeam X-ray fluorescence (SXRF) was used to determine radial distributions of elements in roots and stems with and without EDTA treatment. SXRF maps indicate differences in behavior between Fe and Pb that are consistent with the bulk plant observations and provide insight into changes in metal content of the roots in the presence of EDTA. JF - Journal of environmental radioactivity AU - Fuhrmann, Mark AU - Lanzirotti, Antonio AD - Environmental Sciences Department, Brookhaven National Laboratory, Building 830, P.O. Box 5000, Upton, NY 11973, USA. fuhrmann@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 33 EP - 50 VL - 82 IS - 1 SN - 0265-931X, 0265-931X KW - Cesium Radioisotopes KW - 0 KW - Iron Chelating Agents KW - Metals, Heavy KW - Soil KW - Soil Pollutants KW - Soil Pollutants, Radioactive KW - Quartz KW - 14808-60-7 KW - Citric Acid KW - 2968PHW8QP KW - Edetic Acid KW - 9G34HU7RV0 KW - Iron KW - E1UOL152H7 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Americium KW - VW92PHU2UY KW - Index Medicus KW - Citric Acid -- pharmacology KW - Cesium Radioisotopes -- analysis KW - Spectrometry, X-Ray Emission KW - Iron -- chemistry KW - Cesium Radioisotopes -- metabolism KW - Plant Stems -- chemistry KW - Plant Roots -- chemistry KW - Ascorbic Acid -- pharmacology KW - Iron -- metabolism KW - Edetic Acid -- pharmacology KW - Edetic Acid -- chemistry KW - Metals, Heavy -- metabolism KW - Tobacco -- drug effects KW - Tobacco -- chemistry KW - Soil Pollutants -- metabolism KW - Americium -- metabolism KW - Americium -- analysis KW - Tobacco -- metabolism KW - Iron Chelating Agents -- pharmacology KW - Soil Pollutants, Radioactive -- metabolism KW - Soil Pollutants, Radioactive -- analysis KW - Soil Pollutants -- analysis KW - Metals, Heavy -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67742545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+radioactivity&rft.atitle=241Am%2C+137Cs%2C+Sr+and+Pb+uptake+by+tobacco+as+influenced+by+application+of+Fe+chelators+to+soil.&rft.au=Fuhrmann%2C+Mark%3BLanzirotti%2C+Antonio&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2005-01-01&rft.volume=82&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+radioactivity&rft.issn=0265931X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-01 N1 - Date created - 2005-04-14 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Porphyrin-mediated boron neutron capture therapy: a preclinical evaluation of the response of the oral mucosa. AN - 67340483; 15606309 AB - Preclinical studies are in progress to determine the potential of boron neutron capture therapy (BNCT) for the treatment of carcinomas of the head and neck. Recently, it has been demonstrated that various boronated porphyrins can target a variety of tumor types. Of the porphyrins evaluated so far, copper tetracarboranylphenyl porphyrin (CuTCPH) is potentially a strong candidate for clinical use. In the present investigation, the response of the oral mucosa to CuTCPH-mediated boron neutron capture (BNC) irradiation was assessed using the ventral surface of the tongue of adult male Fischer 344 rats, a standard rodent model. CuTCPH was administered by intravenous infusion, at a dose of 200 mg/kg body weight, over a 48-h period. Three days after the end of the administration of CuTCPH, biodistribution studies indicated very low levels of boron (<2 microg/g) in the blood. Levels of boron in tongue tissue were 39.0 +/- 3.8 microg/g at this time. This was the time selected for irradiation with single doses of thermal neutrons from the Brookhaven Medical Research Reactor. The estimated level of boron-10 in the oral mucosa was used in the calculation of the physical radiation doses from the 10B(n,alpha)7Li reaction. This differs from the approach using the present generation of clinical boron carriers, where boron levels in blood at the time of irradiation are used for this calculation. Dose-response curves for the incidence of mucosal ulceration were fitted using probit analysis, and the doses required to produce a 50% incidence of the effect (ED50 +/- SE) were calculated. Analysis of the dose-effect data for CuTCPH-mediated BNC irradiation, compared with those for X rays and thermal neutrons alone, gave a compound biological effectiveness (CBE) factor of approximately 0.04. This very low CBE factor would suggest that there was relatively low accumulation of boron in the key target epithelial stem cells of the oral mucosa. As a consequence, with low levels of boron (<2 microg/g) in the blood, the response of the oral mucosa to CuTCPH-mediated BNCT will be governed primarily by the radiation effects of the thermal neutron beam and not from the boron neutron capture reaction [10B(n,alpha)7Li]. JF - Radiation research AU - Morris, G M AU - Coderre, J A AU - Micca, P L AU - Nawrocky, M M AU - Hopewell, J W AU - Miura, M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 72 EP - 78 VL - 163 IS - 1 SN - 0033-7587, 0033-7587 KW - Metalloporphyrins KW - 0 KW - copper tetracarboranyltetraphenylporphyrin KW - Index Medicus KW - Space life sciences KW - Rats KW - Animals KW - Relative Biological Effectiveness KW - Rats, Inbred F344 KW - Radiotherapy Dosage KW - Body Burden KW - Treatment Outcome KW - Lethal Dose 50 KW - Tissue Distribution KW - Dose-Response Relationship, Radiation KW - Drug Evaluation, Preclinical KW - Female KW - Oral Ulcer -- pathology KW - Mouth Mucosa -- pathology KW - Boron Neutron Capture Therapy -- adverse effects KW - Mouth Mucosa -- radiation effects KW - Metalloporphyrins -- adverse effects KW - Metalloporphyrins -- therapeutic use KW - Boron Neutron Capture Therapy -- methods KW - Oral Ulcer -- etiology KW - Radiation Injuries -- pathology KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67340483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Porphyrin-mediated+boron+neutron+capture+therapy%3A+a+preclinical+evaluation+of+the+response+of+the+oral+mucosa.&rft.au=Morris%2C+G+M%3BCoderre%2C+J+A%3BMicca%2C+P+L%3BNawrocky%2C+M+M%3BHopewell%2C+J+W%3BMiura%2C+M&rft.aulast=Morris&rft.aufirst=G&rft.date=2005-01-01&rft.volume=163&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-03-08 N1 - Date created - 2004-12-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Variable-temperature structural studies of tetranatrolite from Mt. Saint-Hilaire; synchrotron X-ray powder diffraction and Rietveld analysis AN - 51734230; 2005-023546 AB - The temperature-dependent evolution of the crystal structure of natural tetranatrolite (Mt. Saint-Hilaire, approximate formula Na (sub 5.85) Ca (sub 1.90) Al (sub 9.25) Si (sub 10.75) O (sub 40) .11H (sub 2) O) was investigated using monochromatic synchrotron X-ray powder diffraction and Rietveld analysis. The room-temperature structural model reveals characteristic Al/Si and Na/Ca disordering over the framework tetrahedral and nonframework cation sites, respectively. Water molecules at the OW4 and OW5 sites along the elliptical channels surround the nonframework cations with full and partial occupancies, respectively, similar to what was observed in previous single crystal studies. As the temperature increases up to 300 degrees C, the partially occupied OW5 site is gradually dehydrated whereas the fully occupied OW4 site and the disordered Na/Ca site remain fully occupied. Upon complete dehydration of the OW5 site at 300 degrees C, another phase appears with approximately 1.8% expansion and approximately 6.7% reduction of the a- and c-axis parameters, respectively, leading to an overall volume reduction of approximately 3.3%. In this new phase, the Na and Ca atoms migrate to occupy two closely separated sites along the channels, and 80% of the OW4 water is lost with the remaining water molecules occupying a site close to the previously empty OW5 site. The material decomposes upon full dehydration near 400 degrees C and becomes X-ray amorphous. The temperature-dependent variations of the T-O-T angles and the chain rotation angle are indicative of the framework relaxation occurring during the selective dehydration and subsequent cation-water migration phase transition. JF - American Mineralogist AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Vogt, Thomas Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 247 EP - 251 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - X-ray diffraction data KW - Quebec KW - phase transitions KW - crystal structure KW - Rietveld refinement KW - natrolite KW - Mont-Saint-Hilaire Quebec KW - order-disorder KW - Canada KW - tetranatrolite KW - zeolite group KW - Rouville County Quebec KW - framework silicates KW - Eastern Canada KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51734230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water%2C+Air%2C+%26+Soil+Pollution&rft.atitle=Using+Lidar+to+Measure+Perfluorocarbon+Tracers+for+the+Verification+and+Monitoring+of+Cap+and+Cover+Systems&rft.au=Heiser%2C+John+H%3BSedlacek%2C+Arthur+J&rft.aulast=Heiser&rft.aufirst=John&rft.date=2006-02-01&rft.volume=170&rft.issue=1-4&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Water%2C+Air%2C+%26+Soil+Pollution&rft.issn=00496979&rft_id=info:doi/10.1007%2Fs11270-005-9007-8 L2 - http://www.minsocam.org/MSA/AmMin/TOC/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 20 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2014-03-14 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - Canada; crystal structure; Eastern Canada; framework silicates; Mont-Saint-Hilaire Quebec; natrolite; order-disorder; phase transitions; Quebec; Rietveld refinement; Rouville County Quebec; silicates; tetranatrolite; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.2138/am.2005.1696 ER - TY - JOUR T1 - Pressure-induced stabilization of ordered paranatrolite; a new insight into the paranatrolite controversy AN - 51733412; 2005-023547 AB - The origin and stability of paranatrolite (approximate formula Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) .4H (sub 2) O), a naturally occurring zeolite with the natrolite topology, has long been debated, with its detailed structure unknown. When taken from an aqueous environment and exposed to the atmosphere, paranatrolite is reported to irreversibly lose water and transform to gonnardite/tetranatrolite, Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) .nH (sub 2) O. Since the latter has a disordered Al/Si distribution over the framework tetrahedral sites, it is believed the same is true for paranatrolite. Natrolite itself (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) .16H (sub 2) O) has Al/Si ordering, and as recently shown, undergoes a reversible volume expansion ( approximately 2.5%) due to pressure-induced hydration (PIH) above 1.2 GPa to a superhydrated phase (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) .32H (sub 2) O). During this process, an intermediate phase with an even larger volume expansion of approximately 7.0% has been detected in a narrow pressure range near 1.0 GPa. We report here that this intermediate phase has a unit-cell compatible with the one reported for paranatrolite at ambient conditions with the same 24 water molecules per formula unit and propose that it is paranatrolite with an ordered Al/Si distribution. An unusual water-sodium chain is observed in the ordered paranatrolite structure: a sevenfold coordination of sodium cations provided by alternating two water bridges along the expanded elliptical channels. The density of the ordered paranatrolite is lower than those of the 16 and 32 water phases, with its channel openings far more circular than in the low-and high-pressure analogs. The atomistic details of the ordered paranatrolite provide a structural model for the naturally occurring paranatrolite and a complete understanding of this intriguing pressure-volume-hydration mechanism in natrolite, demonstrating the unique role of pressure in controlling the chemistry of microporous materials. JF - American Mineralogist AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Parise, John B AU - Vogt, Thomas Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 252 EP - 257 PB - Mineralogical Society of America, Washington, DC VL - 90 IS - 1 SN - 0003-004X, 0003-004X KW - silicates KW - cell dimensions KW - experimental studies KW - pressure KW - stability KW - crystal structure KW - natrolite KW - order-disorder KW - laboratory studies KW - paranatrolite KW - zeolite group KW - framework silicates KW - crystal chemistry KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51733412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Pressure-induced+stabilization+of+ordered+paranatrolite%3B+a+new+insight+into+the+paranatrolite+controversy&rft.au=Lee%2C+Yongjae%3BHriljac%2C+Joseph+A%3BParise%2C+John+B%3BVogt%2C+Thomas&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2005-01-01&rft.volume=90&rft.issue=1&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/10.2138%2Fam.2005.1588 L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - cell dimensions; crystal chemistry; crystal structure; experimental studies; framework silicates; laboratory studies; natrolite; order-disorder; paranatrolite; pressure; silicates; stability; zeolite group DO - http://dx.doi.org/10.2138/am.2005.1588 ER - TY - JOUR T1 - Molecular monitoring of SRB community structure and dynamics in batch experiments to examine the applicability of in situ precipitation of heavy metals for groundwater remediation AN - 51654473; 2006-001398 AB - Background, Aims and Scope. Sulfate-reducing bacteria (SRB) are known for their capacity to reduce and precipitate heavy metals (HM) as metal sulfides, offering the opportunity to create an in situ reactive zone for the treatment of heavy metal-contaminated groundwater, a process called in situ metal precipitation (ISMP). The applicability of the ISMP technology first has to be investigated at a laboratory scale before going into an on site application. The evaluation and optimization of the ISMP process is facilitated when physical/chemical analysis techniques are combined with molecular tools that specifically monitor the abundance, diversity and dynamics of the indigenous sulfate reducing microbial community. In this study, batch experiments were conducted in order to investigate the feasibility of ISMP as a groundwater remediation strategy for an industrial site contaminated with elevated levels of Zn, Cd, Co and Ni. Methods. The potential of different types of carbon source/electron donor (lactate, acetate, methanol, ethanol, Hydrogen Release Compound (super R) , molasses) to stimulate the sulfate reduction and metal precipitation activity of the naturally present (or indigenous) SRB community was explored. In addition, the effect of amending vitamin B12 and yeast extract was evaluated. The ISMP process was monitored by combining analytical analyzes of process parameters (SO (sub 4) (super 2-) -concentration, heavy metal concentrations, pH, E (sub h) ) with molecular tools such as SRB subgroup and genus specific PCR, denaturing gradient gel electrophoresis (DGGE), and phylogenetic analysis of clone sequences, based on either the 16S rRNA or the dsr (dissimilatory sulfite reductase) gene. Results and Discussion. The efficiency of different carbon-sources to stimulate the ISMP process followed the order HRC > molasses > methanol > lactate > ethanol > acetate. Within 10 weeks, the highest sulfate and metal removal efficiencies ranged from 85% to 99%. Addition of yeast extract boosted the ISMP process, whereas vitamin B12 negligibly affected SRB activity. Analysis of the sulfate reducing population by SRB subgroup and genus specific PCR demonstrated that members of the genus Desulfosporosinus dominated in all batch tests, while 16S rDNA DGGE profiles additionally revealed the presence in the microbial communities of non-sulfate reducing bacteria within the family Clostridium and the epsilon -proteobacteria. The dsrB-based DGGE profiles allowed us to assess the diversity and dynamics of the sulfate reducing community and added to a better understanding of the effects of different batch conditions on the ISMP process. Remarkably, all dsrB sequences affiliated with the dsrB gene sequence cluster found in Desulfotomaculum, which received their xenologous dsrB gene from the delta -proteobacteria. Conclusions. The batch experiments, which aimed at stimulating the activities of the indigenous SRB communities, demonstrated that these communities were present and that their activities could be used to obtain efficient in situ precipitation of the contaminating heavy metals. This opens the possibility to test this concept in the future as an on site demonstration as part of the groundwater strategy for the heavy metal contaminated site. Although batch setups are suitable for preliminary feasibility studies for ISMP, they do not reflect the in situ situation where sulfate and heavy metal and metalloid polluted groundwater are supplied continuously. A sulfate reducing strain JG32A was isolated from whose 16S rRNA gene affiliated with the genus Desulfosporosinus, while its dsrB gene sequence clustered with Desulfotomaculum dsrB gene sequences, which received their xenologous dsr genes from delta -proteobacteria. Therefore we hypothesize that the batch experiments enrich members of the Desulfosporosinus genus that possess a non-orthologous dsrB gene. Recommendation and Perspective. The next step towards an on site pilot test for ISMP will be the setup of a series of column experiments, with process conditions that are selected based on the above mentioned results. This will allow to define optimal ISMP process conditions and to test its long-term efficacy and sustainability before going into an on site bioremediation application. By applying the described molecular tools together with physical-chemical analyzes, it can be investigated whether the same SRB community is enriched and which type of C-source is most effective in promoting and sustaining its growth and sulfate-reduction activity. JF - Journal of Soils and Sediments AU - Geets, Joke AU - Borremans, Brigitte AU - Vangronsveld, Jaco AU - Diels, Ludo AU - van der Lelie, Daniel Y1 - 2005 PY - 2005 DA - 2005 SP - 149 EP - 163 PB - Ecomed Publishers, Landsberg VL - 5 IS - 3 SN - 1439-0108, 1439-0108 KW - experimental studies KW - monitoring KW - Western Europe KW - in situ KW - sulfates KW - pollutants KW - Kempen Belgium KW - pollution KW - Europe KW - bioremediation KW - remediation KW - ground water KW - aquifers KW - case studies KW - laboratory studies KW - precipitation KW - Belgium KW - bacteria KW - DNA KW - reduction KW - sulfides KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51654473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=Molecular+monitoring+of+SRB+community+structure+and+dynamics+in+batch+experiments+to+examine+the+applicability+of+in+situ+precipitation+of+heavy+metals+for+groundwater+remediation&rft.au=Geets%2C+Joke%3BBorremans%2C+Brigitte%3BVangronsveld%2C+Jaco%3BDiels%2C+Ludo%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Geets&rft.aufirst=Joke&rft.date=2005-01-01&rft.volume=5&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/10.1065%2Fjss2004.12.125 L2 - http://www.springerlink.com/(kugcki55vur4xmjtv2myls45)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:112850,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 37 N1 - Document feature - illus. incl. 6 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aquifers; bacteria; Belgium; bioremediation; case studies; DNA; Europe; experimental studies; ground water; heavy metals; in situ; Kempen Belgium; laboratory studies; monitoring; pollutants; pollution; precipitation; reduction; remediation; sulfates; sulfides; Western Europe DO - http://dx.doi.org/10.1065/jss2004.12.125 ER - TY - JOUR T1 - Basic considerations for Monte Carlo calculations in soil AN - 51512887; 2007-005308 JF - Applied Radiation and Isotopes AU - Hanson, Albert L AU - Song, Zhiguang AU - Orion, Itzhak AU - Hendrey, George Y1 - 2005/01// PY - 2005 DA - January 2005 SP - 97 EP - 107 PB - Elsevier, Oxford VL - 62 IS - 1 SN - 0969-8043, 0969-8043 KW - soils KW - silicates KW - neutron methods KW - secondary minerals KW - moisture KW - Monte Carlo analysis KW - grain size KW - statistical analysis KW - data processing KW - weathering KW - porosity KW - physical properties KW - neutrons KW - gamma rays KW - sensitivity analysis KW - digital simulation KW - probability KW - chemical composition KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51512887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Radiation+and+Isotopes&rft.atitle=Basic+considerations+for+Monte+Carlo+calculations+in+soil&rft.au=Hanson%2C+Albert+L%3BSong%2C+Zhiguang%3BOrion%2C+Itzhak%3BHendrey%2C+George&rft.aulast=Hanson&rft.aufirst=Albert&rft.date=2005-01-01&rft.volume=62&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Applied+Radiation+and+Isotopes&rft.issn=09698043&rft_id=info:doi/10.1016%2Fj.apradiso.2004.06.003 L2 - http://www.sciencedirect.com/science/journal/09698043 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 24 N1 - Document feature - illus. incl. 5 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - chemical composition; data processing; digital simulation; gamma rays; grain size; moisture; Monte Carlo analysis; neutron methods; neutrons; physical properties; porosity; probability; secondary minerals; sensitivity analysis; silicates; soils; statistical analysis; weathering DO - http://dx.doi.org/10.1016/j.apradiso.2004.06.003 ER - TY - JOUR T1 - Response to Newman: New uses of endophytic bacteria to improve phytoremediation AN - 20848101; 6185210 JF - Trends in Biotechnology AU - van der Lelie, D AU - Barac, T AU - Taghavi, S AU - Vangronsveld, J Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 8 EP - 9 VL - 23 IS - 1 SN - 0167-7799, 0167-7799 KW - Pollution Abstracts; Biotechnology and Bioengineering Abstracts KW - Phytoremediation KW - Endophytes KW - Reviews KW - phytoremediation KW - Biotechnology KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biotechnology&rft.atitle=Response+to+Newman%3A+New+uses+of+endophytic+bacteria+to+improve+phytoremediation&rft.au=van+der+Lelie%2C+D%3BBarac%2C+T%3BTaghavi%2C+S%3BVangronsveld%2C+J&rft.aulast=van+der+Lelie&rft.aufirst=D&rft.date=2005-01-01&rft.volume=23&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biotechnology&rft.issn=01677799&rft_id=info:doi/10.1016%2Fj.tibtech.2004.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Endophytes; Reviews; phytoremediation; Phytoremediation; Biotechnology DO - http://dx.doi.org/10.1016/j.tibtech.2004.11.008 ER - TY - JOUR T1 - Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin AN - 19930525; 6463438 AB - Clostridial neurotoxins are comprised of botulinum (BoNT) and tetanus (TeNT), which share significant structural and functional similarity. Crystal structures of the binding domain of TeNT complexed with disialyllactose (DiSia) and a tri-peptide Tyr-Glu-Trp (YEW) have been determined to 2.3 and 2.2 Aa, respectively. Both DiSia and YEW bind in a shallow cleft region on the surface of the molecule in the beta -trefoil domain, interacting with a set of common residues, Asp1147, Asp1214, Asn1216, and Arg1226. DiSia and YEW binding at the same site in tetanus toxin provides a putative site that could be occupied either by a ganglioside moiety or a peptide. Soaking experiments with a mixture of YEW and DiSia show that YEW competes with DiSia, suggesting that YEW can be used to block ganglioside binding. A comparison with the TeNT binding domain in complex with small molecules, BoNT/A and /B, provides insight into the different modes of ganglioside binding. Proteins 2005. Published 2005 Wiley-Liss, Inc. JF - Proteins: Structure, Function & Bioinformatics AU - Jayaraman, Seetharaman AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York, swami@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 288 EP - 295 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 61 IS - 2 SN - 0887-3585, 0887-3585 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - tetanus neurotoxin KW - GD3 KW - ganglioside KW - X-ray crystallography KW - [beta]-trefoil KW - inhibitors KW - Protein structure KW - Structure-function relationships KW - Crystal structure KW - Gangliosides KW - tetanus toxin KW - Bioinformatics KW - Neurotoxins KW - Tetanus KW - N3 11007:Neurobiology KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19930525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.atitle=Common+binding+site+for+disialyllactose+and+tri-peptide+in+C-fragment+of+tetanus+neurotoxin&rft.au=Jayaraman%2C+Seetharaman%3BEswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BSwaminathan%2C+Subramanyam&rft.aulast=Jayaraman&rft.aufirst=Seetharaman&rft.date=2005-01-01&rft.volume=61&rft.issue=2&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Proteins%3A+Structure%2C+Function+%26+Bioinformatics&rft.issn=08873585&rft_id=info:doi/10.1002%2Fprot.20595 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein structure; Structure-function relationships; Crystal structure; Bioinformatics; tetanus toxin; Gangliosides; Tetanus; Neurotoxins DO - http://dx.doi.org/10.1002/prot.20595 ER - TY - JOUR T1 - Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region AN - 19671830; 7436469 AB - The development of positron emission tomography (PET) ligands for the norepinephrine transporter (NET) has been slow compared to the development of radiotracers for others systems, such as the dopamine (DAT) or the serotonin transporters (SERT). The main reason for this appears to be the high nonspecific (non-NET) binding exhibited by many of these tracers, which makes the identification of a reference region difficult. With other PET ligands the use of a reference region increases the reproducibility of the outcome measure in test/retest studies. The focus of this work is to identify a suitable reference region or means of normalizing data for the NET ligands investigated. Methods: We have analyzed the results of PET studies in the baboon brain with labeled reboxetine derivatives (S, S)-[ super(11)C]O-methyl reboxetine (SS-MRB), (S, S)-[ super(18)F]fluororeboxetine (SS-FRB) as well as O-[ super(11)C]nisoxetine and N-[ super(11)C]nisoxetme (NIS), and, for comparison, the less active (R, R) enantiomers (RR-MRB, RR-FRB) in terms of the distribution volume (DV) using measured arterial input functions. Results: (1) For a given subject, a large variation in DV for successive baseline studies was observed in regions with both high and low NET density. (2) The occipital cortex and the basal ganglia were found to be the regions with the smallest change between baseline (SS-MRB) and pretreatment with cocaine, and were therefore used as a composite reference region for calculation of a distribution volume ratio (DVR). (3) The variability [as measured by the coefficient of variation (CV)=standard deviation/mean] in the distribution volume ratio (DVR) of thalamus (to reference region) was considerably reduced over that of the DV using this composite reference region. (4) Pretreatment with nisoxetine (1.0 mg/kg 10 min prior to tracer) in one study produced (in decreasing order) reductions in thalamus, cerebellum, cingulate and frontal cortex consistent with known NET densities. (5) [ super(11)C]Nisoxetine had a higher background non-NET binding (DV) than the other tracers reported here with basal ganglia (a non-NET region) higher than thalamus. Conclusions: The reboxetine derivatives show a lot of promise as tracers for human PET studies of the norepinephrine system. We have identified a strategy for normalizing DVs to a reference region with the understanding that the DVR for these tracers may not be related to the binding potential in the same way as, for example, for the dopamine tracers, since the non-NET binding may differ between the target and nontarget regions. From our baboon studies the average DVR for thalamus (n = 18) for SS-MRB is 1.8; however, the lower limit is most likely less than 1 due to this difference in non-NET binding. JF - Nuclear Medicine and Biology AU - Logan, J AU - Ding, Y-S AU - Lin, K-S AU - Pareto, D AU - Fowler, J AU - Biegon, A AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA, logan@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 531 EP - 542 VL - 32 IS - 5 SN - 0969-8051, 0969-8051 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Cerebellum KW - reboxetine KW - Thalamus KW - Tracers KW - Baseline studies KW - Dopamine transporter KW - Dopamine KW - Norepinephrine transporter KW - Positron emission tomography KW - Cocaine KW - Papio KW - Cortex (occipital) KW - Brain KW - Cortex (frontal) KW - Cortex (cingulate) KW - Enantiomers KW - Norepinephrine KW - Serotonin transporter KW - Basal ganglia KW - W 30950:Waste Treatment & Pollution Clean-up KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19671830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.atitle=The+relationship+between+Cambrian-Ordovician+high-TOC+source+rock+development+and+paleoenvironment+variations+in+the+Tarim+Basin%2C+western+China%3B+carbon+and+oxygen+isotope+evidence&rft.au=Zhang%2C+Shuichang%3BWang%2C+Ruiliang%3BJin%2C+Zhijun%3BZhang%2C+Baomin%3BWang%2C+Darui%3BBian%2C+Lizeng&rft.aulast=Zhang&rft.aufirst=Shuichang&rft.date=2006-03-01&rft.volume=80&rft.issue=3&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Dizhixue+Bao+%3D+Acta+Geologica+Sinica&rft.issn=00015717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Papio; Positron emission tomography; Tracers; Thalamus; reboxetine; Serotonin transporter; Basal ganglia; Dopamine transporter; Norepinephrine transporter; Cerebellum; Cocaine; Dopamine; Enantiomers; Baseline studies; Cortex (cingulate); Cortex (frontal); Cortex (occipital); Brain; Norepinephrine DO - http://dx.doi.org/10.1016/j.nucmedbio.2005.04.005 ER - TY - JOUR T1 - fMRI-acoustic noise alters brain activation during working memory tasks AN - 19450387; 6965399 AB - Scanner noise during functional magnetic resonance imaging (fMRI) may interfere with brain function and change blood oxygenation level dependent (BOLD) signals, a problem that generally worsens at the higher field strengths. Therefore, we studied the effect of increased acoustic noise on fMRI during verbal working memory (WM) processing. The sound pressure level of scanner noise was increased by 12 dBA from "Quiet" to "Loud" echo planar imaging (EPI) scans by utilizing resonant vibration modes of the gradient coil. A WM paradigm with graded levels of task difficulty was used to further access WM load. Increased scanner noise produced increased BOLD responses (percent signal change) bilaterally in the cerebellum, inferior (IFG), medial (medFG), and superior (SFG) frontal, fusiform (FusG), and the lingual (LG) gyri, and decreased BOLD responses bilaterally in the anterior cingulate gyrus (ACG) and the putamen. This finding suggests greater recruitment of attention resources in these brain regions, probably to compensate for interference due to louder scanner noise. Increased working memory load increased the BOLD signals in IFG and the cerebellum, but decreased the BOLD signals in the putamen and the LG. These findings also support the idea that brain function requires additional attention resources under noisier conditions. Load- and acoustic-noise-related changes in BOLD responses correlated negatively in the WM network. This study demonstrates that MR noise affects brain activation pattern. Future comparisons between studies performed under different acoustic conditions (due to differing magnetic field strengths, pulse sequences, or scanner manufacturers) might require knowledge of the sound pressure level of acoustic noise during fMRI. JF - NeuroImage AU - Tomasi, D AU - Caparelli, E C AU - Chang, L AU - Ernst, T AD - Medical Department, Bldg. 490, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA, tomasi@bnl.gov Y1 - 2005 PY - 2005 DA - 2005 SP - 377 EP - 386 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Cerebellum KW - Short term memory KW - Putamen KW - Sound KW - Pressure KW - Acoustics KW - Recruitment KW - Brain KW - Vibrations KW - Magnetic fields KW - Language KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19450387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=fMRI-acoustic+noise+alters+brain+activation+during+working+memory+tasks&rft.au=Tomasi%2C+D%3BCaparelli%2C+E+C%3BChang%2C+L%3BErnst%2C+T&rft.aulast=Tomasi&rft.aufirst=D&rft.date=2005-01-01&rft.volume=27&rft.issue=2&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.04.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Functional magnetic resonance imaging; Short term memory; Acoustics; Putamen; Sound; Cerebellum; Pressure; Vibrations; Language; Magnetic fields; Neuroimaging; Recruitment DO - http://dx.doi.org/10.1016/j.neuroimage.2005.04.010 ER - TY - JOUR T1 - A comparative study of ozone production in five U.S. metropolitan areas AN - 19428843; 6133558 AB - We present observations of O sub(3) and O sub(3) precursors measured at mid boundary layer altitude during field campaigns in Nashville, Tennessee (1995), New York City, New York (1996), Phoenix, Arizona (1998), Philadelphia, Pennsylvania (1999), and Houston, Texas (2000). Ozone production rates P(O sub(3)) and their sensitivity to NO sub( x ) and volatile organic carbons (VOCs) are calculated using observed concentrations as inputs to a steady state box model. City to city comparisons are made to illustrate common features of urban photochemistry and features that are unique to specific cities. Ozone production rates vary from nearly zero to 155 ppb h super(-1). Differences in P(O sub(3)) depend on precursor concentrations, namely, radical sources, NO sub( x ) and VOCs. Under conditions where P(O sub(3)) is greater than 25 ppb h super(-1), there is a potential to produce enough same-day O sub(3) to transform a typical regional background into a severe O sub(3) episode. Six such cases were observed, in Nashville, Philadelphia, and Houston, with elevated O sub(3) concentrations in the afternoon (130-211 ppb) following a morning in which P(O sub(3)) was 25-140 ppb h super(-1). High P(O sub(3)) occurs when NO sub( x ) concentrations are 5-25 ppb and OH-VOC reactivity is above 5 s super(-1). These conditions are infrequent, and aside from a common dependence on calm winds, reasons vary from city to city. In Nashville, high P(O sub(3)) was observed during a stagnation event over downtown and under the circumstance that an air mass with a high concentration of isoprene encountered a NO sub( x ) source. In Houston, NO sub( x ) and light olefins are coemitted from petrochemical facilities leading to the highest P(O sub(3))s of the five cities studied. High values of P(O sub(3)) did not occur in Phoenix because of low radical production, caused mainly by a dry atmosphere, and a low VOC to NO sub( x ) ratio. The sensitivity of P(O sub(3)) to its precursors varied from NO sub( x ) limited in rural samples to VOC limited near emission sources. In Philadelphia, and especially Phoenix, the highest O sub(3) production rates occurred under VOC-limited conditions. In Nashville, New York City, and Houston the high-P(O sub(3)) samples were near the ridge line where P(O sub(3)) responds somewhat to VOC reductions but is insensitive to NO sub( x ) changes. JF - Journal of Geophysical Research. D. Atmospheres AU - Kleinman, LI AU - Daum, PH AU - Lee, Y-N AU - Nunnermacker, L J AU - Springston AU - Weinstein-Lloyd, J AU - Rudolph, J AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2005/01// PY - 2005 DA - Jan 2005 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 110 IS - D2 SN - 0148-0227, 0148-0227 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Citation No. D02301 KW - photochemistry KW - ozone production rate KW - ozone precursors KW - 0365 Atmospheric Composition and Structure: Troposphere: composition and chemistry KW - 0345 Atmospheric Composition and Structure: Pollution: urban and regional (0305, 0478, 4251) KW - 0317 Atmospheric Composition and Structure: Chemical kinetic and photochemical properties. KW - Photochemistry KW - Photochemistry of atmospheric pollution KW - USA, Pennsylvania, Philadelphia KW - Air quality KW - USA, New York KW - Ozone-volatile organic compounds relationships KW - Air quality models KW - USA, New York, New York KW - USA, Tennessee KW - Ozone production KW - Ozone-nitrogen oxides relationships KW - Boundary layers KW - Ozone in urban air KW - USA, Pennsylvania KW - Atmospheric chemistry KW - USA, Arizona KW - USA, Texas, Houston KW - Volatile organic compounds KW - USA, Arizona, Phoenix KW - USA, Tennessee, Nashville KW - Urban areas KW - Ozone KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=A+comparative+study+of+ozone+production+in+five+U.S.+metropolitan+areas&rft.au=Kleinman%2C+LI%3BDaum%2C+PH%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BSpringston%3BWeinstein-Lloyd%2C+J%3BRudolph%2C+J&rft.aulast=Kleinman&rft.aufirst=LI&rft.date=2005-01-01&rft.volume=110&rft.issue=D2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2004JD005096 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-03-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Ozone-nitrogen oxides relationships; Ozone production; Photochemistry of atmospheric pollution; Ozone in urban air; Air quality models; Ozone-volatile organic compounds relationships; Photochemistry; Boundary layers; Atmospheric chemistry; Air quality; Volatile organic compounds; Ozone; Urban areas; USA, New York, New York; USA, Tennessee; USA, Pennsylvania, Philadelphia; USA, Pennsylvania; USA, Arizona; USA, Texas, Houston; USA, Tennessee, Nashville; USA, New York; USA, Arizona, Phoenix DO - http://dx.doi.org/10.1029/2004JD005096 ER - TY - JOUR T1 - Linking enzyme sequence to function using conserved property difference AN - 19421049; 6644031 AB - Families of homologous enzymes evolved from common progenitors. The JF - BMC Bioinformatics AU - Mayer, Kimberly M AU - McCorkle, Sean R AU - Shanklin, John AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005 PY - 2005 DA - 2005 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 IS - 1 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 284 KW - Stem cells KW - Conserved sequence KW - Enzymes KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19421049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Linking+enzyme+sequence+to+function+using+conserved+property+difference&rft.au=Mayer%2C+Kimberly+M%3BMcCorkle%2C+Sean+R%3BShanklin%2C+John&rft.aulast=Mayer&rft.aufirst=Kimberly&rft.date=2005-01-01&rft.volume=6&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-6-284 L2 - http://www.biomedcentral.com/1471-2105/6/284 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enzymes; Conserved sequence; Bioinformatics; Stem cells DO - http://dx.doi.org/10.1186/1471-2105-6-284 ER - TY - JOUR T1 - The dependence of tropospheric ozone production rate on ozone precursors AN - 16188727; 6137043 AB - An analytic formula is derived expressing the tropospheric O sub(3) production rate, P(O sub(3)), as a power law function of radical production rate, NO sub(x) concentration, and VOC-OH reactivity. Power law exponents depend on a single parameter, L sub(N)/Q, which is the fraction of free radicals removed by reactions with NO sub(x). The formula reproduces the functional form of P(O sub(3)) obtained from photochemical box model calculations. Ozone production rates are shown to have a smooth transition between previously derived low and high NO sub(x) limits. Potential applications of this formula include analysis of day to day and place to place variations in P(O sub(3)), with P(O sub(3)) either obtained from measurements collected during field campaigns or produced as output from chemical-transport models. JF - Atmospheric Environment AU - Kleinman, LI AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2005/01// PY - 2005 DA - Jan 2005 SP - 575 EP - 586 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone production rate KW - Tropospheric photochemistry KW - Ozone sensitivity KW - Low and high NO sub(x) KW - Ozone precursors KW - Troposphere KW - Nitrogen oxides KW - Tropospheric chemistry KW - Ozone in troposphere KW - Ozone production KW - Photochemicals KW - Chemical reactions KW - Atmospheric chemistry KW - Nitrogen oxides in troposphere KW - Photochemical models KW - Volatile organic compounds KW - Ozone KW - P 0000:AIR POLLUTION KW - M2 551.510.3/.4:Physical Properties/Composition (551.510.3/.4) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16188727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure+of+the+Mycobacterium+tuberculosis+proteasome+and+mechanism+of+inhibition+by+a+peptidyl+boronate&rft.au=Hu%2C+Guiqing%3BLin%2C+Gang%3BWang%2C+Ming%3BDick%2C+Lawrence%3BXu%2C+Rui-Ming%3BNathan%2C+Carl%3BLi%2C+Huilin&rft.aulast=Hu&rft.aufirst=Guiqing&rft.date=2006-03-01&rft.volume=59&rft.issue=5&rft.spage=1417&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.05036.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-04-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Ozone in troposphere; Ozone production; Nitrogen oxides in troposphere; Photochemical models; Ozone; Tropospheric chemistry; Photochemicals; Chemical reactions; Atmospheric chemistry; Troposphere; Nitrogen oxides; Volatile organic compounds DO - http://dx.doi.org/10.1016/j.atmosenv.2004.08.047 ER - TY - JOUR T1 - Residential radon exposure and lung cancer risk: commentary on Cohen's county-based study. AN - 67070905; 15545771 AB - The large United States county-based study () in which an inverse relationship has been suggested between residential low-dose radon levels and lung cancer mortality has been reviewed. While this study has been used to evaluate the validity of the linear nonthreshold theory, the grouped nature of its data limits the usefulness of this application. Our assessment of the study's approach, including a reanalysis of its data, also indicates that the likelihood of strong, undetected confounding effects by cigarette smoking, coupled with approximations of data values and uncertainties in accuracy of data sources regarding levels of radon exposure and intensity of smoking, compromises the study's analytic power. The most clear data for estimating lung cancer risk from low levels of radon exposure continue to rest with higher-dose studies of miner populations in which projections to zero dose are consistent with estimates arising from most case-control studies regarding residential exposure. JF - Health physics AU - Heath, C W AU - Bond, P D AU - Hoel, D G AU - Meinhold, C B AD - Physics Department, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 647 EP - 55; discussion 656-8 VL - 87 IS - 6 SN - 0017-9078, 0017-9078 KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - Risk KW - Humans KW - Smoking -- adverse effects KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- etiology KW - Radon -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67070905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Residential+radon+exposure+and+lung+cancer+risk%3A+commentary+on+Cohen%27s+county-based+study.&rft.au=Heath%2C+C+W%3BBond%2C+P+D%3BHoel%2C+D+G%3BMeinhold%2C+C+B&rft.aulast=Heath&rft.aufirst=C&rft.date=2004-12-01&rft.volume=440&rft.issue=7081&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04593 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-09 N1 - Date created - 2004-11-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Adsorption of rare earth elements by gamma -Al (sub 2) O (sub 3) and Pseudomonas fluorescens cells in the presence of desferrioxamine B; implication of siderophores for the Ce anomaly AN - 51736400; 2005-026370 AB - We investigated the influence of siderophore desferrioxamine B (DFO) on the adsorption behavior of 11 rare-earth elements (REEs), La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, and Er, on gamma -Al (sub 2) O (sub 3) and Pseudomonas fluorescens cells at neutral pH. In the presence of DFO, the adsorption of REEs on gamma -Al (sub 2) O (sub 3) and P. fluorescens cells showed a tendency to decrease with an increase of their atomic number, except for Ce. The adsorption of Ce was significantly lower than those of the neighboring REEs, La and Pr. X-ray absorption near edge structure (XANES) analysis of the Ce-DFO complex showed that Ce was in the tetravalent state. Adding hydroxylammonium reduced the tetravalent Ce in the complex to its trivalent form with the disappearance of the Ce anomaly. These results show that DFO can oxidize Ce(III) to Ce(IV), which was supported by electrochemical experiments. Cyclic voltammetry (CV) revealed that the redox potential of the Ce(IV)/Ce(III) couple in the DFO complex was much lower than the standard redox potential, and that the stability of Ce(IV)-DFO is much higher than that of Ce(III)-DFO. These findings suggest that the Ce anomaly we observed is due to the oxidation of Ce(III)-DFO complex to the more stable Ce(IV)-DFO complex, and that naturally occurring organic ligands can contribute to Ce anomaly observed in the natural environment. JF - Chemical Geology AU - Yoshida, Takahiro AU - Ozaki, Takuo AU - Ohnuki, Toshihiko AU - Francis, Arokiasamy J A2 - Fortin, Danielle A2 - Takahashi, Yoshio A2 - Feriis, F. Grant Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 239 EP - 246 PB - Elsevier, Amsterdam VL - 212 IS - 3-4 SN - 0009-2541, 0009-2541 KW - mass spectra KW - Pseudomonas KW - electrochemical properties KW - remediation KW - cerium KW - XANES spectra KW - siderophores KW - aluminum oxides KW - oxides KW - valency KW - spectra KW - rare earths KW - trace elements KW - Eh KW - voltammetry KW - pollution KW - anomalies KW - adsorption KW - bioremediation KW - X-ray spectra KW - ICP mass spectra KW - desferrioxamine B KW - metals KW - bacteria KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51736400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Adsorption+of+rare+earth+elements+by+gamma+-Al+%28sub+2%29+O+%28sub+3%29+and+Pseudomonas+fluorescens+cells+in+the+presence+of+desferrioxamine+B%3B+implication+of+siderophores+for+the+Ce+anomaly&rft.au=Yoshida%2C+Takahiro%3BOzaki%2C+Takuo%3BOhnuki%2C+Toshihiko%3BFrancis%2C+Arokiasamy+J&rft.aulast=Yoshida&rft.aufirst=Takahiro&rft.date=2004-12-01&rft.volume=212&rft.issue=3-4&rft.spage=239&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2004.08.046 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 37 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - adsorption; aluminum oxides; anomalies; bacteria; bioremediation; cerium; desferrioxamine B; Eh; electrochemical properties; ICP mass spectra; mass spectra; metals; oxides; pollution; Pseudomonas; rare earths; remediation; siderophores; spectra; trace elements; valency; voltammetry; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2004.08.046 ER - TY - JOUR T1 - Mechanisms of arsenic immobilization in a biomat from mine discharge water AN - 51731816; 2005-026374 AB - We studied the mechanism of uptake of arsenic (As) in a bacterial microhabitat, a biomat, from discharged arsenic mine water at pH 4.7 in field and laboratory experiments. The mine water contained a yellowish biomat composed mainly of Fe-bearing compounds and associated microorganisms. Concentrations of As and Fe in the water decreased with increasing distance from the location of the discharge position. The spatial distributions of elements in the biomat collected at 0.3 m downstream from the discharge position, determined by scanning-particle-induced X-ray emission analysis (S-PIXE), indicated that As was co-located with Fe and S in the precipitates. Analyses of the precipitates by X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) revealed the presence of Fe-S-bearing minerals, such as schwertmannite and an unknown one, having a d-spacing of 3.3 Aa. X-ray absorption near edge structure (XANES) analysis of the precipitates indicated that the oxidation states of As and Fe were V and III, respectively, whereas their corresponding oxidation states in the discharged mine water were V and II. After storing fresh mine water, collected 0.3 m downstream of the discharge position, for 17 days there was a decrease in As and Fe concentrations from 1.2X10 (super -6) and 1.8X10 (super -4) mol L (super -1) to 3.6X10 (super -7) and 2.0X10 (super -5) mol L (super -1) , respectively, with the concomitant formation of a yellowish precipitate. In contrast, in filter-sterilized (0.2 mu m) mine water there was no change in their concentrations. Molecular analysis, based on the 16S rDNA fragment extracted from the discharged mine water, indicated that Gallionella sp. was the predominant microorganism present. It is known to form stalk-like and sheath-like compounds that were distinguished in the precipitates by TEM observation. These results demonstrate that As(V) in the discharged mine water is co-precipitated with and/or adsorbed on Fe-S-bearing minerals in the biomat. JF - Chemical Geology AU - Ohnuki, Toshihiko AU - Sakamoto, Fuminori AU - Kozai, Naofumi AU - Ozaki, Takuo AU - Yoshida, Takahiro AU - Narumi, Issay AU - Wakai, Eiichi AU - Sakai, Takuro AU - Francis, Arokiasamy J A2 - Fortin, Danielle A2 - Takahashi, Yoshio A2 - Feriis, F. Grant Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 279 EP - 290 PB - Elsevier, Amsterdam VL - 212 IS - 3-4 SN - 0009-2541, 0009-2541 KW - Far East KW - X-ray diffraction data KW - Gallionella KW - mass spectra KW - PIXE spectra KW - iron KW - remediation KW - emission spectra KW - XANES spectra KW - spectra KW - discharge KW - chemical composition KW - Asia KW - geochemistry KW - pH KW - abandoned mines KW - mines KW - acid mine drainage KW - pollutants KW - Gumma Japan KW - arsenic KW - pollution KW - adsorption KW - bioremediation KW - hydrochemistry KW - X-ray spectra KW - TEM data KW - biota KW - ICP mass spectra KW - precipitation KW - metals KW - bacteria KW - mobilization KW - Honshu KW - Japan KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51731816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Geology&rft.atitle=Mechanisms+of+arsenic+immobilization+in+a+biomat+from+mine+discharge+water&rft.au=Ohnuki%2C+Toshihiko%3BSakamoto%2C+Fuminori%3BKozai%2C+Naofumi%3BOzaki%2C+Takuo%3BYoshida%2C+Takahiro%3BNarumi%2C+Issay%3BWakai%2C+Eiichi%3BSakai%2C+Takuro%3BFrancis%2C+Arokiasamy+J&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2004-12-01&rft.volume=212&rft.issue=3-4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Chemical+Geology&rft.issn=00092541&rft_id=info:doi/10.1016%2Fj.chemgeo.2004.08.018 L2 - http://www.sciencedirect.com/science/journal/00092541 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 43 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - CHGEAD N1 - SubjectsTermNotLitGenreText - abandoned mines; acid mine drainage; adsorption; arsenic; Asia; bacteria; bioremediation; biota; chemical composition; discharge; emission spectra; Far East; Gallionella; geochemistry; Gumma Japan; Honshu; hydrochemistry; ICP mass spectra; iron; Japan; mass spectra; metals; mines; mobilization; pH; PIXE spectra; pollutants; pollution; precipitation; remediation; spectra; TEM data; X-ray diffraction data; X-ray spectra; XANES spectra DO - http://dx.doi.org/10.1016/j.chemgeo.2004.08.018 ER - TY - JOUR T1 - Carbon cycling in soil AN - 51707502; 2005-044453 AB - As yet, nobody knows what effects climate change will have on soil carbon reserves, or how those changes will affect the global carbon cycle. Soils are the primary terrestrial repository for carbon, so minor changes in the balance between belowground carbon storage and release could have major impacts on greenhouse gases. Soil fauna, roots, fungi, and microbes interact with mineral and organic matter to process soil carbon. Studies have been hampered by the difficulty of observing processes beneath the earth's surface, but advances in science and technology are improving our ability to understand belowground ecosystems. JF - Frontiers in Ecology and the Environment AU - Johnston, Carol A AU - Groffman, Peter AU - Breshears, David D AU - Cardon, Zoe G AU - Currie, William AU - Emanuel, William AU - Gaudinski, Julia AU - Jackson, Robert B AU - Lajtha, Kate AU - Nadelhoffer, Knute AU - Nelson, David, Jr AU - Post, W Marc AU - Retallack, Gregory AU - Wielopolski, Lucian Y1 - 2004/12// PY - 2004 DA - December 2004 SP - 522 EP - 528 PB - Ecological Society of America, Washington, DC VL - 2 IS - 10 SN - 1540-9295, 1540-9295 KW - climatic controls KW - technology KW - data acquisition KW - data processing KW - aliphatic hydrocarbons KW - rhizosphere KW - ecosystems KW - vegetation KW - climate change KW - carbon dioxide KW - carbon KW - retention KW - ecology KW - greenhouse effect KW - soils KW - concentration KW - soil profiles KW - methane KW - bulk density KW - roots KW - nitrous oxide KW - agriculture KW - pollution KW - alkanes KW - measurement KW - geochemical cycle KW - habitat KW - carbon monoxide KW - organic compounds KW - hydrocarbons KW - carbon cycle KW - land use KW - instruments KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51707502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Ecology+and+the+Environment&rft.atitle=Carbon+cycling+in+soil&rft.au=Johnston%2C+Carol+A%3BGroffman%2C+Peter%3BBreshears%2C+David+D%3BCardon%2C+Zoe+G%3BCurrie%2C+William%3BEmanuel%2C+William%3BGaudinski%2C+Julia%3BJackson%2C+Robert+B%3BLajtha%2C+Kate%3BNadelhoffer%2C+Knute%3BNelson%2C+David%2C+Jr%3BPost%2C+W+Marc%3BRetallack%2C+Gregory%3BWielopolski%2C+Lucian&rft.aulast=Johnston&rft.aufirst=Carol&rft.date=2004-12-01&rft.volume=2&rft.issue=10&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Ecology+and+the+Environment&rft.issn=15409295&rft_id=info:doi/ L2 - http://www.frontiersinecology.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - agriculture; aliphatic hydrocarbons; alkanes; bulk density; carbon; carbon cycle; carbon dioxide; carbon monoxide; climate change; climatic controls; concentration; data acquisition; data processing; ecology; ecosystems; geochemical cycle; greenhouse effect; habitat; hydrocarbons; instruments; land use; measurement; methane; microorganisms; nitrous oxide; organic compounds; pollution; retention; rhizosphere; roots; soil profiles; soils; technology; vegetation ER - TY - JOUR T1 - Dosimetry and risk from low- versus high-LET radiation of Auger events and the role of nuclide carriers. AN - 67261019; 15764388 AB - PURPOSETo analyse the lethality to mammalian cells of (125)I-decays in DNA, in antipyrine in the whole cell and in oligodeoxynucleotides in the nucleus outside DNA as a function of Auger event-site and number.MATERIALS AND METHODSAuger events cause both low- and high-linear energy transfer energy depositions including charge neutralization at the daughter nuclide. Microdosimetry allows the expression of absorbed dose to a defined micromass and the number of such events at given sites. Published data were used to relate micromass dose and event number to the dose to reduce survival to 37% of the initial survival (D37).RESULTSThe D37 of (125)I-decays in DNA was 0.1 Gy in terms of absorbed dose to the cell nucleus and about 30 in terms of average decays per nucleus or whole cell. The D37 of (125)I-decays in antipyrine was 1.5 Gy for absorbed dose to the cell nucleus, about 250 in terms of average decays per nucleus and about 2 x 10(3) for average decays per whole cell. (125)I-decays in oligodeoxynucleotides were much less toxic than (125)I-decays in antipyrine by a factor of about 25 in terms of average absorbed dose to the cell nucleus, by a factor or about 40 in terms of average decays per cell nucleus and by a factor of six in terms of average decays per whole cell.CONCLUSIONThe unexpected low toxicity of (125)I-decays in nuclear oligodeoxynucleotides outside the DNA in comparison with (125)I-decays in antipyrine in the nucleus or the whole cell demands further attention on the role of oligodeoxynucleotides in altering cellular radiation sensitivity. JF - International journal of radiation biology AU - Feinendegen, L E AU - Neumann, R D AD - Brookhaven National Laboratory, Upton, NY, USA. PY - 2004 SP - 813 EP - 822 VL - 80 IS - 11-12 SN - 0955-3002, 0955-3002 KW - Iodine Radioisotopes KW - 0 KW - Oligonucleotides KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Animals KW - Electrons KW - Risk Factors KW - Humans KW - Apoptosis -- radiation effects KW - Dose-Response Relationship, Radiation KW - Cell Survival -- radiation effects KW - Cell Nucleus -- radiation effects KW - Cell Physiological Phenomena -- radiation effects KW - Iodine Radioisotopes -- adverse effects KW - Oligonucleotides -- radiation effects KW - Linear Energy Transfer -- physiology KW - Risk Assessment -- methods KW - Radiometry -- methods KW - Oligonucleotides -- metabolism KW - DNA -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/67261019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.atitle=Improved+Representation+of+Cloud+Droplet+Activation+and+Autoconversion+and+their+Implications+for+Estimating+Aerosol+Indirect+Effects&rft.au=Liu%2C+Y%3BDaum%2C+P%3BMcgraw%2C+R%3BMiller%2C+M&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-04-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+European+Geosciences+Union+General+Assembly+%28EGU+2006%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-04-06 N1 - Date created - 2005-03-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Decreased brain dopaminergic transporters in HIV-associated dementia patients. AN - 66984998; 15319273 AB - HIV has a propensity to invade subcortical regions of the brain, which may lead to a subcortical dementia termed HIV-cognitive motor complex. Therefore, we aimed to assess whether dopamine (DA) D2 receptors and transporters (DAT) are affected in the basal ganglia of subjects with HIV, and how these changes relate to dementia status. Fifteen HIV subjects (age 44.5 +/- 11 years; CD4 185 +/- 130/mm3)) and 13 seronegative controls (42 +/- 12 years) were evaluated with PET to assess availability of DAT ([11C]cocaine) and DA D2 receptor ([11C]raclopride). HIV patients with associated dementia (HAD), but not those without dementia (ND) had significantly lower DAT availability in putamen (-19.3%, P = 0.009) and ventral striatum (-13.6%, P = 0.03) compared with seronegative controls. Higher plasma viral load in the HIV dementia patients correlated with lower DAT in the caudate (r = -0.7, P = 0.02) and putamen (r = -0.69, P = 0.03). DA D2 receptor availability, however, showed mild and non-significant decreases in HIV patients. These results provide the first evidence of DA terminal injury in HIV dementia patients, and suggest that decreased DAT may contribute to the pathogenesis of HIV dementia. The greater DAT decrease in the putamen than in the caudate parallels that observed in Parkinson's disease. The inverse relationship between viral burden and DAT availability further supports HIV-mediated neurotoxicity to dopaminergic terminals. JF - Brain : a journal of neurology AU - Wang, Gene-Jack AU - Chang, Linda AU - Volkow, Nora D AU - Telang, Frank AU - Logan, Jean AU - Ernst, Thomas AU - Fowler, Joanna S AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, NY, USA. Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 2452 EP - 2458 VL - 127 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - RNA, Viral KW - Receptors, Dopamine D2 KW - SLC6A3 protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Positron-Emission Tomography KW - Humans KW - Adult KW - HIV -- isolation & purification KW - Aged KW - Middle Aged KW - Male KW - Female KW - Receptors, Dopamine D2 -- metabolism KW - RNA, Viral -- blood KW - AIDS Dementia Complex -- diagnostic imaging KW - AIDS Dementia Complex -- metabolism KW - AIDS Dementia Complex -- virology KW - Nerve Tissue Proteins -- metabolism KW - Brain -- metabolism KW - Membrane Transport Proteins -- metabolism KW - Brain -- diagnostic imaging KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66984998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%3A+a+journal+of+neurology&rft.atitle=Decreased+brain+dopaminergic+transporters+in+HIV-associated+dementia+patients.&rft.au=Wang%2C+Gene-Jack%3BChang%2C+Linda%3BVolkow%2C+Nora+D%3BTelang%2C+Frank%3BLogan%2C+Jean%3BErnst%2C+Thomas%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-11-01&rft.volume=127&rft.issue=&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=Brain+%3A+a+journal+of+neurology&rft.issn=1460-2156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-18 N1 - Date created - 2004-10-19 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Pressure-induced stabilization of ordered paranatrolite; a possible solution to the paranatrolite controversy AN - 51692557; 2005-053573 AB - The origin and stability of paranatrolite (approximate formula Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) . 24H (sub 2) O), a naturally occurring zeolite with the natrolite topology, has long been debated, with its detailed structure unknown. When taken from an aqueous environment and exposed to the atmosphere, paranatrolite is reported to irreversibly lose water and transform to gonnardite/tetranatrolite, Na (sub 16-x) Ca (sub x) Al (sub 16+x) Si (sub 24-x) O (sub 80) . nH (sub 2) O. Since the latter has a disordered Al/Si distribution over the framework tetrahedral sites, it is believed the same is true for paranatrolite. Natrolite itself (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) . 16H (sub 2) O) has Al/Si ordering, and as recently shown, undergoes a reversible volume expansion ( approximately 2.5%) due to pressure-induced hydration (PIH) above 1.2 GPa to a superhydrated phase (Na (sub 16) Al (sub 16) Si (sub 24) O (sub 80) . 32H (sub 2) O). During this process, an intermediate phase with an even larger volume expansion of approximately 7.0% has been detected in a narrow pressure range near 1.0 GPa. We report here that this intermediate phase has a unit cell compatible with the one reported for paranatrolite at ambient conditions with the same 24 water molecules per formula unit and propose that it is paranatrolite with an ordered Al/Si distribution. An unusual water-sodium chain is observed in the ordered paranatrolite: a seven-fold coordination of sodium cations provided by alternating two water bridges along the expanded elliptical channels. The density of the ordered paranatrolite is lower than those of the 16 and 32 water phases, with its channel openings far more circular than its low and high pressure analogs. The atomistic details of the ordered paranatrolite provide a structural model for the naturally occurring paranatrolite and a complete understanding of this intriguing pressure-volume-hydration mechanism in natrolite, demonstrating the unique role of pressure in controlling the chemistry of microporous materials. JF - Abstracts with Programs - Geological Society of America AU - Lee, Yongjae AU - Hriljac, Joseph A AU - Parise, John B AU - Vogt, Thomas AU - Anonymous Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 113 PB - Geological Society of America (GSA), Boulder, CO VL - 36 IS - 5 SN - 0016-7592, 0016-7592 KW - silicates KW - pressure KW - crystal structure KW - natrolite KW - order-disorder KW - hydration KW - controls KW - paranatrolite KW - zeolite group KW - topology KW - framework silicates KW - crystal chemistry KW - formula KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51692557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Pressure-induced+stabilization+of+ordered+paranatrolite%3B+a+possible+solution+to+the+paranatrolite+controversy&rft.au=Lee%2C+Yongjae%3BHriljac%2C+Joseph+A%3BParise%2C+John+B%3BVogt%2C+Thomas%3BAnonymous&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2004-11-01&rft.volume=36&rft.issue=5&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2004 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - controls; crystal chemistry; crystal structure; formula; framework silicates; hydration; natrolite; order-disorder; paranatrolite; pressure; silicates; topology; zeolite group ER - TY - JOUR T1 - High-temperature synchrotron XRD studies of Zn/Mn-oxides; a comparison of dehydration mechanisms in chalcophanite and woodruffite AN - 51692336; 2005-053572 AB - Chalcophanite (ZnMn (sub 3) O (sub 7) . 3H (sub 2) O) and woodruffite (Zn (sub 0.7) Mn (sub 3.45) O (sub 7) . 2.4H (sub 2) O) form in oxidizing zones of Zn- and Mn-bearing deposits. Chalcophanite is constructed of sheets of Mn (super 4+) -O octahedra with Zn and H (sub 2) O between the layers. One of seven octahedral sites in the Mn-O sheet is vacant, and the Zn cations sit above and below the vacancies (Post and Appleman 1988). Among the birnessite-like layer Mn oxides, chalcophanite is unique in its tendency to form crystals suitable for detailed structural analysis, thereby providing special insight into this environmentally important mineral group. Post et al (2003) recently determined that the woodruffite structure consists of large tunnels that measure 3 and 4 octahedra on a side, the largest of any yet reported in natural or synthetic Mn oxides. The woodruffite structure may serve as a model for a new class of octahedral molecular sieves with enhanced capabilities as catalysts and selective cation-exchange agents. We have used in situ, temperature-resolved synchrotron powder X-ray diffraction to investigate the thermal stability and dehydration behaviors of chalcophanite and woodruffite. The data were collected at the National Synchrotron Light Source using an imaging plate. Samples of chalcophanite and woodruffite were each heated in glass capillaries in air from 26 to 800 degrees C. Our results revealed that as chalcophanite loses interlayer H (sub 2) O between approximately 175 and 200 degrees C, the interlayer spacing collapses from 7.3 to 4.8, forming the anhydrous phase ZnMn (sub 3) O (sub 7) . The interlayer Zn changes from octahedral coordination (to 3O and 3H (sub 2) O) in chalcophanite to tetrahedral coordination in the anhydrous phase. Above approximately 500 degrees C, the Mn-O distances increase and exhibit Jahn-Teller type distortions indicating reduction of some Mn (super 4+) to Mn (super 3+) on the octahedral sites. Also above approximately 500 degrees C, the anhydrous chalcophanite phase starts transforming into the Zn/Mn spinel, hetearolite [(Zn (sub .75) Mn (sub .25) )Mn (sub 2) O (sub 4) ]. By approximately 700 degrees C, this conversion is complete. Dehydration in woodruffite also leads to a spinel-like phase, but the reaction sequence is similar to that of todorokite, which has a 3X3 tunnel topology. The collapse of the woodruffite structure and loss of H (sub 2) O at approximately 300 degrees C is triggered by the loss of O atoms from the octahedral framework and the consequent reduction of Mn, followed by the appearance of a Zn/Mn spinel. JF - Abstracts with Programs - Geological Society of America AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan C AU - Anonymous Y1 - 2004/11// PY - 2004 DA - November 2004 SP - 112 EP - 113 PB - Geological Society of America (GSA), Boulder, CO VL - 36 IS - 5 SN - 0016-7592, 0016-7592 KW - X-ray data KW - manganese oxides KW - oxides KW - chalcophanite KW - dehydration KW - high temperature KW - zinc oxides KW - woodruffite KW - temperature KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51692336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=High-temperature+synchrotron+XRD+studies+of+Zn%2FMn-oxides%3B+a+comparison+of+dehydration+mechanisms+in+chalcophanite+and+woodruffite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2004-11-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Conference+on+Hurricanes+and+Tropical+Meteorology&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2004 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - chalcophanite; dehydration; high temperature; manganese oxides; oxides; temperature; woodruffite; X-ray data; zinc oxides ER - TY - JOUR T1 - Uncertainty Requirements in Radiative Forcing of Climate Change AN - 20631402; 6248447 AB - The continuing increase in atmospheric carbon dioxide (CO2) makes it essential that climate sensitivity, the equilibrium change in global mean surface temperature that would result from a given radiative forcing, be quantified with known uncertainty. Present estimates are quite uncertain, 3 +- 1.5 K for doubling of CO2. Model studies examining climate response to forcing by greenhouse gases and aerosols exhibit large differences in sensitivities and imposed aerosol forcings that raise questions regarding claims of their having reproduced observed large-scale changes in surface temperature over the 20th century. Present uncertainty in forcing, caused largely by uncertainty in forcing by aerosols, precludes meaningful model evaluation by comparison with observed global temperature change or empirical determination of climate sensitivity. Uncertainty in aerosol forcing must be reduced at least three-fold for uncertainty in climate sensitivity to be meaningfully reduced and bounded. JF - Journal of the Air & Waste Management Association AU - Schwartz, SE AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, NY, USA Y1 - 2004/11// PY - 2004 DA - Nov 2004 VL - 54 IS - 11 SN - 1096-2247, 1096-2247 KW - radiative forcing KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Surface temperatures KW - Aerosols KW - Climate models KW - Climatic changes KW - Climate change KW - Temperature KW - Radiative forcing KW - Climate sensitivity KW - Global temperature changes KW - Atmospheric chemistry KW - Carbon dioxide KW - Atmospheric aerosols KW - Greenhouse gases KW - M2 551.583:Variations (551.583) KW - P 0000:AIR POLLUTION KW - M2 551.521.1/.18:Solar (551.521.1/.18) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20631402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Uncertainty+Requirements+in+Radiative+Forcing+of+Climate+Change&rft.au=Schwartz%2C+SE&rft.aulast=Schwartz&rft.aufirst=SE&rft.date=2004-11-01&rft.volume=54&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-07-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Surface temperatures; Radiative forcing; Climate models; Global temperature changes; Climate sensitivity; Climate change; Greenhouse gases; Atmospheric aerosols; Carbon dioxide; Aerosols; Climatic changes; Atmospheric chemistry; Temperature ER - TY - JOUR T1 - Analysis of temperature and pressure changes in liquefied natural gas (LNG) cryogenic tanks AN - 20978940; 6074707 AB - Liquefied natural gas (LNG) is being developed as a transportation fuel for heavy vehicles such as trucks and transit buses, to lessen the dependency on oil and to reduce greenhouse gas emissions. The LNG stations are properly designed to prevent the venting of natural gas (NG) from LNG tanks, which can cause evaporative greenhouse gas emissions and result in fluctuations of fuel flow and changes of fuel composition. Boil-off is caused by the heat added into the LNG fuel during the storage and fueling. Heat can leak into the LNG fuel through the shell of tank during the storage and through hoses and dispensers during the fueling. Gas from tanks onboard vehicles, when returned to LNG tanks, can add additional heat into the LNG fuel. A thermodynamic and heat transfer model has been developed to analyze different mechanisms of heat leak into the LNG fuel. The evolving of properties and compositions of LNG fuel inside LNG tanks is simulated. The effect of a number of buses fueled each day on the possible total fuel loss rate has been analyzed. It is found that by increasing the number of buses, fueled each day, the total fuel loss rate can be reduced significantly. It is proposed that an electric generator be used to consume the boil-off gas or a liquefier be used to re-liquefy the boil-off gas to reduce the tank pressure and eliminate fuel losses. These approaches can prevent boil-off of natural gas emissions, and reduce the costs of LNG as transportation fuel. JF - Cryogenics AU - Chen, Q-S AU - Wegrzyn, J AU - Prasad, V AD - Institute of Mechanics, Chinese Academy of Sciences 15 Bei Si Huan Xi Road, Beijing 100080, China, jwegrzyn@bnl.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 701 EP - 709 PB - Butterworth Scientific Ltd. VL - 44 IS - 10 SN - 0011-2275, 0011-2275 KW - Pollution Abstracts KW - Liquefied natural gas KW - Transportation fuel KW - Cryogenics KW - Thermodynamics KW - Heat transfer , Nomenclature KW - buses KW - Motor vehicles KW - Fuels KW - Temperature KW - Natural gas KW - Storage KW - Oil KW - Transportation KW - electric generators KW - Emissions KW - heat transfer KW - Trucks KW - Greenhouse gases KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20978940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cryogenics&rft.atitle=Analysis+of+temperature+and+pressure+changes+in+liquefied+natural+gas+%28LNG%29+cryogenic+tanks&rft.au=Chen%2C+Q-S%3BWegrzyn%2C+J%3BPrasad%2C+V&rft.aulast=Chen&rft.aufirst=Q-S&rft.date=2004-10-01&rft.volume=44&rft.issue=10&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Cryogenics&rft.issn=00112275&rft_id=info:doi/10.1016%2Fj.cryogenics.2004.03.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - buses; Thermodynamics; Fuels; Motor vehicles; Temperature; Natural gas; Oil; Storage; Liquefied natural gas; Transportation; electric generators; Emissions; heat transfer; Trucks; Greenhouse gases DO - http://dx.doi.org/10.1016/j.cryogenics.2004.03.020 ER - TY - JOUR T1 - Phasing in iodine for structure determination AN - 17701292; 6088819 AB - A new method for solving X-ray crystal structures relies on the introduction of iodine into proteins in the form of p-iodophenylalanine. JF - Nature Biotechnology AU - Dauter, Z AD - Synchrotron Radiation Research Section of the National Cancer Institute, Brookhaven National Laboratory Bldg 725A, Upton, NY 11973, USA, dauter@bnl.gov Y1 - 2004/10// PY - 2004 DA - Oct 2004 SP - 1239 EP - 1240 VL - 22 IS - 10 SN - 1087-0156, 1087-0156 KW - p-iodophenylalanine KW - Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Reviews KW - Crystal structure KW - Iodine KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17701292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Phasing+in+iodine+for+structure+determination&rft.au=Dauter%2C+Z&rft.aulast=Dauter&rft.aufirst=Z&rft.date=2004-10-01&rft.volume=22&rft.issue=10&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews; Iodine; Crystal structure ER - TY - JOUR T1 - Oligomeric State of the Escherichia coli Metal Transporter YiiP AN - 17827475; 6029988 AB - YiiP is a 32.9-kDa metal transporter found in the plasma membrane of Escherichia coli (Chao, Y., and Fu, D. (2004) J. Biol. Chem. 279, 17173-17180). Here we report the determination of the YiiP oligomeric state in detergent-lipid micelles and in membranes. Molecular masses of YiiP solubilized with dodecyl-, undecyl-, decyl-, or nonyl-beta-D-maltoside were measured directly using size- exclusion chromatography coupled with laser light-scattering photometry, yielding a mass distribution of YiiP homo-oligomers within a narrow range (68.0- 68.8 kDa) that equals the predicted mass of a YiiP dimer within experimental error. The detergent-lipid masses associated with YiiP in the mixed micelles were found to increase from 135.5 to 232.6 kDa, with an apparent correlation with the alkyl chain length of the maltoside detergents. Cross-linking the detergent-solubilized YiiP with 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) resulted in a dimeric cross-linked product in an EDC concentration-dependent manner. The oligomeric state of the purified YiiP in reconstituted membranes was determined by electron microscopic analysis of two- dimensional YiiP crystals in negative stain. A projection structure calculated from measurable optical diffractions to 25 Aa revealed a pseudo-2-fold symmetry within a molecular boundary of -75 x 40 Aa, indicative of the presence of YiiP dimers in membranes. These data provide direct structural evidence for a dimeric association of YiiP both in detergent-lipid micelles and in the reconstituted lipid bilayer. The functional relevance of the dimeric association in YiiP is discussed. JF - Journal of Biological Chemistry AU - Wei, Yinan AU - Li, Huilin AU - Fu, Dax AD - Department of Biology, Brookhaven National Laboratory, Upton, New York Y1 - 2004/09/17/ PY - 2004 DA - 2004 Sep 17 SP - 39251 EP - 39259 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 38 SN - 0021-9258, 0021-9258 KW - YiiP protein KW - Microbiology Abstracts B: Bacteriology KW - Metals KW - Lipid bilayers KW - Chromatography KW - Detergents KW - carbodiimide KW - Crystals KW - Plasma membranes KW - Micelles KW - Photometry KW - Cross-linking KW - Escherichia coli KW - Lasers KW - Diffraction KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17827475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Oligomeric+State+of+the+Escherichia+coli+Metal+Transporter+YiiP&rft.au=Wei%2C+Yinan%3BLi%2C+Huilin%3BFu%2C+Dax&rft.aulast=Wei&rft.aufirst=Yinan&rft.date=2004-09-17&rft.volume=279&rft.issue=38&rft.spage=39251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Metals; Lipid bilayers; Plasma membranes; Detergents; Cross-linking; Chromatography; Photometry; Micelles; carbodiimide; Lasers; Crystals; Diffraction; Escherichia coli ER - TY - JOUR T1 - Adsorption of trace metals on glass fiber filters. AN - 66859357; 15356258 AB - Filters, containing glass-fiber (GF) filter material, are commonly used as the primary filter or as the prefilter in sampling natural waters and laboratory experiments with high concentrations of suspended solids. We observed that GF filter material removed substantial quantities of trace metals from solutions of low ionic strength at near neutral and slightly acidic pH. The GF material sorbed essentially all Pb and Ag from 5-mL aliquots of solutions containing 0.054 and 0.093 mM, respectively. Somewhat less Ni was sorbed from a 0.099 mM solution. This material retained about 43 micromol of Ag per gram of GF material (4600 microg/g). The Ag and Ni sorption was highest at low KNO(3) concentrations (as background electrolyte) and decreased to a constant concentration of sorbed metal at approximately 10 mM KNO(3). Glass-fiber filter material should only be used with careful testing for the elements of concern under conditions that closely match expected environmental or experimental conditions. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Fitts, Jeffrey P AD - Environmental Sciences Department, Building 830, Brookhaven National Laboratory, Upton, NY 11973, USA. fuhrmann@bnl.gov PY - 2004 SP - 1943 EP - 1944 VL - 33 IS - 5 SN - 0047-2425, 0047-2425 KW - Metals KW - 0 KW - Water Pollutants KW - fiberglass KW - Index Medicus KW - Filtration KW - Adsorption KW - Glass KW - Water Purification -- methods KW - Metals -- isolation & purification KW - Water Pollutants -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66859357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Adsorption+of+trace+metals+on+glass+fiber+filters.&rft.au=Fuhrmann%2C+Mark%3BFitts%2C+Jeffrey+P&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2004-09-01&rft.volume=33&rft.issue=5&rft.spage=1943&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-07 N1 - Date created - 2004-09-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Lauriston S. Taylor Lecture: The evolution of radiation protection--from erythema to genetic risks to risks of cancer to...? AN - 66774128; 15303059 AB - Radiation Protection has evolved and will continue to evolve as new information becomes available, as the result of changes in public perception and concern and, perhaps in the future, as a result of enormous expenditures on reducing small risks. In the early part of the last century it was a sense of real danger among medical Practitioners that prompted the first set of exposure limiting suggestions. Addressing medical concerns continued to be the basis of guidance until after the Second World War. An array of new sources and applications led to new approaches, which modified many of the technical issues but didn't result in substantial changes in the dose limits. Fallout from the first generation of thermonuclear weapons in the 1950's resulted in focusing attention on genetic effects, which continued until the middle 1970's. Data from the Japanese Survivor Studies provided the information for risk based recommendations beginning in 1977 and continue to do so today. Both the ICRP and the NCRP are heavily criticized by both those groups of individuals which believe the risk estimates are underestimated and by those which believe the risks are greatly overestimated. Perhaps both organizations can take some comfort in Saint Thomas Aquinas' suggestion, "In medio virtus." JF - Health physics AU - Meinhold, Charles B Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 9 EP - 248 KW - Radium KW - W90AYD6R3Q KW - Index Medicus KW - United States KW - Erythema -- etiology KW - Radiation Dosage KW - Age Factors KW - History, 20th Century KW - History, 21st Century KW - Humans KW - Congresses as Topic -- history KW - Europe KW - X-Rays KW - International Cooperation KW - Neoplasms -- prevention & control KW - Neoplasms -- etiology KW - Radiation Protection -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66774128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Meinhold%2C+Charles+B&rft.aulast=Meinhold&rft.aufirst=Charles&rft.date=2004-09-01&rft.volume=&rft.issue=&rft.spage=240&rft.isbn=&rft.btitle=Lauriston+S.+Taylor+Lecture%3A+The+evolution+of+radiation+protection--from+erythema+to+genetic+risks+to+risks+of+cancer+to...%3F&rft.title=Lauriston+S.+Taylor+Lecture%3A+The+evolution+of+radiation+protection--from+erythema+to+genetic+risks+to+risks+of+cancer+to...%3F&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-14 N1 - Date created - 2004-08-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration. AN - 66680130; 15236349 AB - Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in the d-isomer. A recent report that intraperitoneally (i.p.) administered l-threo-MP displayed potent, dose-dependent inhibition of cocaine- or apomorphine-induced locomotion in rats, raises the question of whether l-threo-MP has a similar effect when given orally. It has been speculated that l-threo-MP is poorly absorbed in humans when it is given orally because of rapid presystemic metabolism. To investigate whether l-threo-MP or its metabolites can be delivered to the brain when it is given orally, and whether l-threo-MP is pharmacologically active. PET and MicroPET studies were carried out in baboons and rats using orally delivered C-11-labeled d- and l-threo-MP ([methyl-(11)C]d-threo-MP and [methyl-(11)C]l-threo-MP). In addition, we assessed the effects of i.p. l-threo-MP on spontaneous and cocaine-stimulated locomotor activity in mice. There was a higher global uptake of carbon-11 in both baboon and rat brain for oral [(11)C]l-threo-MP than for oral [(11)C]d-threo-MP. Analysis of the chemical form of radioactivity in rat brain after [(11)C]d-threo-MP indicated mainly unchanged tracer, whereas with [(11)C]l-threo-MP, it was mainly a labeled metabolite. The possibility that this labeled metabolite might be [(11)C]methanol or [(11)C]CO(2), derived from demethylation, was excluded by ex vivo studies in rats. When l-threo-MP was given i.p. to mice at a dose of 3 mg/kg, it neither stimulated locomotor activity nor inhibited the increased locomotor activity due to cocaine administration. These results suggest that, in animal models, l-threo-MP or its metabolite(s) is (are) absorbed from the gastrointestinal tract and enters the brain after oral administration, but that l-threo-MP may not be pharmacologically active. These results are pertinent to the question of whether l-threo-MP contributes to the behavioral and side effect profile of MP during treatment of ADHD. JF - Synapse (New York, N.Y.) AU - Ding, Yu-Shin AU - Gatley, S John AU - Thanos, Panayotis K AU - Shea, Colleen AU - Garza, Victor AU - Xu, Youwen AU - Carter, Pauline AU - King, Payton AU - Warner, Don AU - Taintor, Nicholas B AU - Park, Daniel J AU - Pyatt, Bea AU - Fowler, Joanna S AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. ding@bnl.gov Y1 - 2004/09/01/ PY - 2004 DA - 2004 Sep 01 SP - 168 EP - 175 VL - 53 IS - 3 SN - 0887-4476, 0887-4476 KW - Carbon Radioisotopes KW - 0 KW - Central Nervous System Stimulants KW - Dopamine Uptake Inhibitors KW - Methylphenidate KW - 207ZZ9QZ49 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Papio KW - Administration, Oral KW - Animals KW - Central Nervous System Stimulants -- pharmacology KW - Motor Activity -- physiology KW - Mice KW - Rats KW - Rats, Sprague-Dawley KW - Adsorption -- drug effects KW - Isomerism KW - Tomography, Emission-Computed KW - Motor Activity -- drug effects KW - Cocaine -- pharmacology KW - Drug Synergism KW - Female KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Brain -- drug effects KW - Methylphenidate -- pharmacokinetics KW - Brain -- metabolism KW - Methylphenidate -- analogs & derivatives KW - Brain -- diagnostic imaging KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66680130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Brain+kinetics+of+methylphenidate+%28Ritalin%29+enantiomers+after+oral+administration.&rft.au=Ding%2C+Yu-Shin%3BGatley%2C+S+John%3BThanos%2C+Panayotis+K%3BShea%2C+Colleen%3BGarza%2C+Victor%3BXu%2C+Youwen%3BCarter%2C+Pauline%3BKing%2C+Payton%3BWarner%2C+Don%3BTaintor%2C+Nicholas+B%3BPark%2C+Daniel+J%3BPyatt%2C+Bea%3BFowler%2C+Joanna+S%3BVolkow%2C+Nora+D&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2004-09-01&rft.volume=53&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-09 N1 - Date created - 2004-07-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Pressure-induced migration of zeolitic water in laumontite AN - 51743820; 2005-021863 JF - Physics and Chemistry of Minerals AU - Lee, Y AU - Hriljac, J A AU - Vogt, T Y1 - 2004/09// PY - 2004 DA - September 2004 SP - 421 EP - 428 PB - Springer-Verlag, Berlin-New York VL - 31 IS - 7 SN - 0342-1791, 0342-1791 KW - water KW - United States KW - silicates KW - laumontite KW - experimental studies KW - pressure KW - X-ray diffraction data KW - natural materials KW - Litchfield County Connecticut KW - crystal structure KW - Rietveld refinement KW - powder method KW - high pressure KW - Connecticut KW - order-disorder KW - sample preparation KW - Pleasant Valley Connecticut KW - phase equilibria KW - zeolite group KW - framework silicates KW - hydrostatic pressure KW - geophysics KW - 01B:Mineralogy of silicates KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51743820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.atitle=Slotted+Surface+Coil+for+Magnetic+Resonance+Imaging+at+4T&rft.au=Solis%2C+Sergio%3BWang%2C+Ruiliang%3BTomasi%2C+Dardo%3BRodriguez%2C+Alfredo+Odon&rft.aulast=Solis&rft.aufirst=Sergio&rft.date=2006-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Scientific+Meeting+and+Exhibition+of+the+International+Society+for+Magnetic+Resonance+in+Medicine+%28ISMRM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.springerlink.com/content/100449/?p=e597e977f1914094b3810f7e67f0a453&pi=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - PCMIDU N1 - SubjectsTermNotLitGenreText - Connecticut; crystal structure; experimental studies; framework silicates; geophysics; high pressure; hydrostatic pressure; laumontite; Litchfield County Connecticut; natural materials; order-disorder; phase equilibria; Pleasant Valley Connecticut; powder method; pressure; Rietveld refinement; sample preparation; silicates; United States; water; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.1007/s00269-004-0414-y ER - TY - JOUR T1 - Ground-based and aircraft measurements of trace gases in Phoenix, Arizona (1998) AN - 16187832; 5999329 AB - In May and June of 1998, an extensive measurement campaign was fielded in the city of Phoenix and its environs. Measurements were made at ground sites and aboard the Department of Energy's G-1 research aircraft in an effort to understand the production of O sub(3) in this area. Diurnal variations in O sub(3) differed at the upwind Palo Verde, downtown Phoenix Super Site, and downwind Usery Pass surface stations. Air masses entering the metropolitan area had O sub(3) concentrations greater than 40 ppbv. Maximum O sub(3) concentrations near 100 ppbv were observed downtown at 14:00 local standard time; similar concentrations occurred much later in the day at the downwind site. One aircraft case study on 5 June, 1998 is presented to illustrate ozone production in the region. Calculated ozone production rate and efficiency varied from 1 to 7 ppbv h super(-1), and 1-3 molecules of O sub(3) per molecule of NO sub(z), respectively, for this flight. Hydrocarbon apportionment, based upon ground site and aircraft measurements, establishes that biogenic species are not significant contributors to O sub(3) production in the Phoenix area. Therefore, carbon monoxide becomes a major contributor to OH reactivity as the more reactive anthropogenic hydrocarbons become depleted. The relatively low ozone production observed in this study is attributed to a low rate of radical production in the dry atmosphere. JF - Atmospheric Environment AU - Nunnermacker, L J AU - Weinstein-Lloyd, J AU - Kleinman, L AU - Daum, PH AU - Lee, Y N AU - Springston AU - Klotz, P AU - Newman, L AU - Neuroth, G AU - Hyde, P AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Bldg. 815E, Rutherford St. Upton, NY 11973, USA, lindan@bnl.gov Y1 - 2004/09// PY - 2004 DA - Sep 2004 SP - 4941 EP - 4956 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 38 IS - 29 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Ozone KW - Ozone production efficiency KW - Biogenic hydrocarbons KW - Isoprene KW - Carbon monoxide KW - Nitrogen oxides KW - Diurnal variations KW - Hydrocarbons KW - Aircraft observations KW - Atmosphere KW - Trace gases in atmosphere KW - Ozone production KW - Gases KW - Photochemicals KW - Aircraft KW - Atmospheric chemistry KW - Emission standards KW - Urban atmospheric pollution KW - USA, Arizona, Phoenix KW - Urban areas KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16187832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Ground-based+and+aircraft+measurements+of+trace+gases+in+Phoenix%2C+Arizona+%281998%29&rft.au=Nunnermacker%2C+L+J%3BWeinstein-Lloyd%2C+J%3BKleinman%2C+L%3BDaum%2C+PH%3BLee%2C+Y+N%3BSpringston%3BKlotz%2C+P%3BNewman%2C+L%3BNeuroth%2C+G%3BHyde%2C+P&rft.aulast=Nunnermacker&rft.aufirst=L&rft.date=2004-09-01&rft.volume=38&rft.issue=29&rft.spage=4941&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2004.04.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Diurnal variations; Ozone production; Trace gases in atmosphere; Atmospheric chemistry; Aircraft observations; Urban atmospheric pollution; Ozone; Carbon monoxide; Photochemicals; Gases; Aircraft; Hydrocarbons; Emission standards; Nitrogen oxides; Atmosphere; Urban areas; USA, Arizona, Phoenix DO - http://dx.doi.org/10.1016/j.atmosenv.2004.04.033 ER - TY - JOUR T1 - Are endogenous clustered DNA damages induced in human cells? AN - 66716861; 15256220 AB - Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found that two radiosensitive human cell lines (TK6 and WI-L2-NS) accumulated Fpg-oxidized purine clusters and Nth-oxidized pyrimidine clusters but not Nfo-abasic clusters. However, four repair-proficient human lines (MOLT 4, HL-60, WTK1, and 28SC) did not contain significant levels (<5/Gbp) of any cluster type. Cluster levels were independent of p53 status. Measurement of glycosylase levels in 28SC, TK6, and WI-L2-NS cells suggested that depressed hOGG1 and hNth activities in TK6 and WI-L2-NS could be related to oxybase cluster accumulation. Thus, individuals with DNA repair enzyme deficiencies could accumulate potentially cytotoxic and mutagenic clustered DNA damages. The absence of Nfo-detected endogenous clusters in any cells examined suggests that abasic clusters could be a signature of cellular ionizing radiation exposure. JF - Free radical biology & medicine AU - Bennett, Paula V AU - Cintron, Nela S AU - Gros, Laurent AU - Laval, Jacques AU - Sutherland, Betsy M AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2004/08/15/ PY - 2004 DA - 2004 Aug 15 SP - 488 EP - 499 VL - 37 IS - 4 SN - 0891-5849, 0891-5849 KW - Mutagens KW - 0 KW - Oligonucleotides KW - Purines KW - Pyrimidines KW - Tumor Suppressor Protein p53 KW - DNA KW - 9007-49-2 KW - Pyruvate Kinase KW - EC 2.7.1.40 KW - DNA Glycosylases KW - EC 3.2.2.- KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Sensitivity and Specificity KW - Pyrimidines -- chemistry KW - Escherichia coli -- metabolism KW - DNA Repair KW - Electrophoresis KW - HL-60 Cells KW - DNA -- metabolism KW - Humans KW - Cell Line, Tumor KW - Tumor Suppressor Protein p53 -- metabolism KW - Oxidation-Reduction KW - Oligonucleotides -- chemistry KW - DNA Glycosylases -- metabolism KW - Oxidative Stress KW - Purines -- chemistry KW - Cell Line KW - Radiation, Ionizing KW - Pyruvate Kinase -- metabolism KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66716861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Are+endogenous+clustered+DNA+damages+induced+in+human+cells%3F&rft.au=Bennett%2C+Paula+V%3BCintron%2C+Nela+S%3BGros%2C+Laurent%3BLaval%2C+Jacques%3BSutherland%2C+Betsy+M&rft.aulast=Bennett&rft.aufirst=Paula&rft.date=2004-08-15&rft.volume=37&rft.issue=4&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-31 N1 - Date created - 2004-07-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Responses to low doses of ionizing radiation in biological systems. AN - 733324343; 19330141 AB - Biological tissues operate through cells that act together within signaling networks. These assure coordinated cell function in the face of constant exposure to an array of potentially toxic agents, externally from the environment and endogenously from metabolism. Living tissues are indeed complex adaptive systems.To examine tissue effects specific for low-dose radiation, (1) absorbed dose in tissue is replaced by the sum of the energies deposited by each track event, or hit, in a cell-equivalent tissue micromass (1 ng) in all micromasses exposed, that is, by the mean energy delivered by all microdose hits in the exposed micromasses, with cell dose expressing the total energy per micromass from multiple microdoses; and (2) tissue effects are related to cell damage and protective cellular responses per average microdose hit from a given radiation quality for all such hits in the exposed micromasses.The probability of immediate DNA damage per low-linear-energy-transfer (LET) average micro-dose hit is extremely small, increasing over a certain dose range in proportion to the number of hits. Delayed temporary adaptive protection (AP) involves (a) induced detoxification of reactive oxygen species, (b) enhanced rate of DNA repair, (c) induced removal of damaged cells by apoptosis followed by normal cell replacement and by cell differentiation, and (d) stimulated immune response, all with corresponding changes in gene expression. These AP categories may last from less than a day to weeks and be tested by cell responses against renewed irradiation. They operate physiologically against nonradiogenic, largely endogenous DNA damage, which occurs abundantly and continually. Background radiation damage caused by rare microdose hits per micromass is many orders of magnitude less frequent. Except for apoptosis, AP increasingly fails above about 200 mGy of low-LET radiation, corresponding to about 200 microdose hits per exposed micromass. This ratio appears to exceed approximately 1 per day for protracted exposure. The balance between damage and protection favors protection at low cell doses and damage at high cell doses. Bystander effects from high-dosed cells to nonirradiated neighboring cells appear to include both damage and protection.Regarding oncogenesis, a model based on the aforementioned dual response pattern at low doses and dose rates is consistant with the nonlinear reponse data and contradicts the linear no-threshold dose-risk hypothesis for radiation-induced cancer. Indeed, a dose-cancer risk function should include both linear and nonlinear terms. JF - Nonlinearity in biology, toxicology, medicine AU - Feinendegen, Ludwig E AU - Pollycove, Myron AU - Sondhaus, Charles A AD - Nuclear Medicine, Heinrich-Heine-University Düsseldorf, Germany; and Medical Department, Brookhaven National Laboratory, Upton, New York. Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 143 EP - 171 VL - 2 IS - 3 SN - 1540-1421, 1540-1421 KW - radiation low-dose effects KW - hormesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733324343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nonlinearity+in+biology%2C+toxicology%2C+medicine&rft.atitle=Responses+to+low+doses+of+ionizing+radiation+in+biological+systems.&rft.au=Feinendegen%2C+Ludwig+E%3BPollycove%2C+Myron%3BSondhaus%2C+Charles+A&rft.aulast=Feinendegen&rft.aufirst=Ludwig&rft.date=2004-07-01&rft.volume=2&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Nonlinearity+in+biology%2C+toxicology%2C+medicine&rft.issn=15401421&rft_id=info:doi/10.1080%2F15401420490507431 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2009-03-30 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Radiat Prot Dosimetry. 2002;99(1-4):249-51 [12194297] Cancer Res. 1992 Nov 15;52(22):6394-6 [1423287] Science. 1972 Jan 14;175(4018):200-2 [5008441] Int J Radiat Biol. 1999 Jul;75(7):865-73 [10489898] Radiat Environ Biophys. 2000 Jun;39(2):79-87 [10929376] J Nucl Med. 2001 Sep;42(9):26N-32N, 37N [11554390] Science. 1984 Feb 10;223(4636):594-7 [6695170] J Gerontol. 1956 Jul;11(3):298-300 [13332224] Radiat Res. 1998 Mar;149(3):256-62 [9496888] Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):39-47 [3257477] Radiat Res. 1974 Sep;59(3):693-709 [4428016] Adv Biol Med Phys. 1967;11:27-85 [4860235] Int J Radiat Biol. 2002 Oct;78(10):913-21 [12465656] C R Acad Sci III. 1999 Feb-Mar;322(2-3):245-51 [10196680] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5057-62 [12679524] Mutat Res. 1995 Mar;336(2):101-13 [7885381] Mutat Res. 1996 Nov 4;358(2):193-8 [8946024] Hum Exp Toxicol. 1999 Jul;18(7):426-32 [10454071] Environ Health Perspect. 1998 Feb;106 Suppl 1:277-83 [9539019] Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jan;39(1):83-93 [6971822] Radiat Res. 2003 Mar;159(3):320-7 [12600234] Radiat Res. 1992 Jul;131(1):66-71 [1626050] Int J Radiat Biol. 1992 Aug;62(2):177-86 [1355511] Hum Exp Toxicol. 2002 Feb;21(2):65-9 [12102498] Nat Med. 1996 May;2(5):577-80 [8616719] Int J Radiat Biol. 1989 Jul;56(1):107-18 [2569006] Int J Radiat Biol. 2003 Feb;79(2):99-105 [12569013] Int J Radiat Biol. 1997 Apr;71(4):421-7 [9154145] Stem Cells. 1995 May;13 Suppl 1:7-20 [7488971] Int J Radiat Biol. 1998 May;73(5):535-41 [9652811] J Nucl Med. 2001 Jan;42(1):17-20 [11197970] Hum Exp Toxicol. 2002 Feb;21(2):85-90 [12102502] Radiat Res. 1998 May;149(5):517-20 [9588363] J Nucl Med. 2003 Jan;44(1):125; author reply 125-6 [12515886] Nature. 2000 Nov 9;408(6809):239-47 [11089981] Radiat Res. 2001 Aug;156(2):177-80 [11448238] Br J Cancer. 2000 Nov;83(9):1223-30 [11027437] Mutat Res. 1996 Nov 4;358(2):171-83 [8946022] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5061-6 [9560228] Radiat Prot Dosimetry. 2003;105(1-4):39-42 [14526924] Int J Radiat Biol. 1999 Jun;75(6):681-90 [10404997] Radiat Res. 1998 Nov;150(5):497-504 [9806590] Radiat Environ Biophys. 1997 Jun;36(2):85-8 [9271795] Free Radic Biol Med. 1991;11(3):299-306 [1937147] Nature. 1977 Oct 6;269(5628):518-21 [909602] Philos Trans R Soc Lond B Biol Sci. 1996 Nov 29;351(1347):1529-38 [8962440] Radiat Res. 1998 Nov;150(5 Suppl):S60-79 [9806610] Int J Radiat Biol Relat Stud Phys Chem Med. 1988 Jan;53(1):95-102 [3123411] Anticancer Res. 2000 Nov-Dec;20(6B):4115-39 [11205238] Int J Radiat Biol. 2001 May;77(5):541-51 [11382332] Radiat Res. 2002 Nov;158(5):626-33 [12385640] C R Acad Sci III. 1999 Feb-Mar;322(2-3):167-75 [10196669] Radiat Res. 2001 Nov;156(5 Pt 2):618-27 [11604083] Science. 2001 Feb 16;291(5507):1284-9 [11181991] Carcinogenesis. 2000 Mar;21(3):397-404 [10688860] J ICRU. 2011 Apr;11(1):1-31 [24174259] Radiat Environ Biophys. 1999 May;38(1):57-71 [10384956] Radiat Res. 1999 Jun;151(6):717-24 [10360792] Radiat Environ Biophys. 1990;29(4):273-92 [2281134] Radiat Res. 2002 Aug;158(2):181-6 [12105988] Prog Nucleic Acid Res Mol Biol. 1988;35:95-125 [3065826] Health Phys. 1987 May;52(5):663-9 [3570805] Hum Exp Toxicol. 2003 Jun;22(6):290-306; discussion 307, 315-7, 319-23 [12856953] Int J Radiat Biol. 1995 Jul;68(1):47-54 [7629437] Radiat Res. 1998 Dec;150(6):656-62 [9840185] Radiat Res. 1999 Sep;152(3):225-31 [10453082] Free Radic Biol Med. 2000 Aug;29(3-4):323-33 [11035261] Physiol Rev. 1998 Apr;78(2):547-81 [9562038] Radiat Res. 2001 Mar;155(3):397-401 [11182789] Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Mar;45(3):205-15 [6370884] Radiat Res. 2001 Dec;156(6):700-7 [11741493] Radiat Res. 2001 Mar;155(3):402-8 [11182790] Nucleic Acids Res. 1996 Apr 15;24(8):1389-94 [8628669] Mutat Res. 1996 Nov 4;358(2):143-53 [8946019] Radiat Res. 2001 Mar;155(3):387-96 [11182788] Mutat Res. 1992 Sep;275(3-6):257-66 [1383768] Mutat Res. 1996 Nov 4;358(2):185-91 [8946023] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5381-6 [10792040] Biol Pharm Bull. 2003 Jan;26(1):19-23 [12520165] Biochim Biophys Acta. 1998 Aug 24;1381(3):312-8 [9729439] Radiat Res. 2002 Mar;157(3):275-80 [11839089] Health Phys. 1995 Jun;68(6):786-92 [7759256] Eur J Nucl Med. 1991;18(9):740-51 [1936050] Radiat Res. 1996 Oct;146(4):369-73 [8927708] Health Phys. 1990 Jul;59(1):29-34 [2358357] Science. 1998 May 15;280(5366):1066-9 [9582118] J Nucl Med. 2001 Jul;42(7):17N-27N [11441881] Radiat Res. 2003 Sep;160(3):376-9 [12926996] Drug Metab Rev. 1998 May;30(2):225-43 [9606602] Radiat Res. 2003 Jan;159(1):102-8 [12492373] Int J Radiat Biol. 2002 Oct;78(10):931-6 [12465658] N1 - Last updated - 2017-02-22 DO - http://dx.doi.org/10.1080/15401420490507431 ER - TY - JOUR T1 - Synthesis of copper octabromotetracarboranylphenylporphyrin for boron neutron capture therapy and its toxicity and biodistribution in tumour-bearing mice. AN - 66682583; 15238404 AB - Copper tetracarboranyltetraphenylporphyrin (CuTCPH) is a minimally toxic carborane-containing porphyrin that has safely delivered high concentrations of boron for experimental boron neutron capture therapy (BNCT). Copper octabromotetracarboranylphenylporphyrin (CuTCPBr), synthesized by bromination of CuTCPH, is one of several new minimally toxic analogues of CuTCPH being studied in our laboratory, which could possess comparable or better tumour-targeting properties with enhanced tumour cytotoxicity. Its biodistribution, biokinetics and toxicity in mice with subcutaneous EMT-6 (mammary) or SCCVII (squamous cell) carcinomas were compared with those of CuTCPH. The administration of approximately 200 mg kg(-1) of either porphyrin in six intraperitoneal injections over 2 days had no apparent effect, but administration of approximately 400 mg kg(-1) slightly lowered body weights, elevated alanine and aspartate transaminase activities in blood plasma, and depressed blood platelet counts for several days. Enzymes and platelets returned to normal within 5 days after those injections and body weights returned to normal within 2 weeks. High average concentrations of boron from either porphyrin were achieved in the two tumour models from a total dose of approximately 200 mg kg(-1). The high tumour boron concentration decreased slowly while concentrations in blood decreased rapidly. Boron concentrations in brain and skin were consistently lower than in tumour by a factor of 10 or more. Although either CuTCPH or CuTCPBr can be labelled with (64)Cu for imaging by positron emission tomography (PET), CuTCPBr can also be labelled by (76)Br, another PET-imageable nuclide. JF - The British journal of radiology AU - Miura, M AU - Morris, G M AU - Micca, P L AU - Nawrocky, M M AU - Makar, M S AU - Cook, S P AU - Slatkin, D N AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 573 EP - 580 VL - 77 IS - 919 SN - 0007-1285, 0007-1285 KW - Metalloporphyrins KW - 0 KW - copper tetracarboranyltetraphenylporphyrin KW - Boron KW - N9E3X5056Q KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Transplantation KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C3H KW - Mice KW - Tissue Distribution KW - Mice, Inbred BALB C KW - Boron -- pharmacokinetics KW - Female KW - Boron Neutron Capture Therapy -- adverse effects KW - Mammary Neoplasms, Experimental -- radiotherapy KW - Carcinoma, Squamous Cell -- metabolism KW - Boron Neutron Capture Therapy -- methods KW - Mammary Neoplasms, Experimental -- metabolism KW - Carcinoma, Squamous Cell -- radiotherapy KW - Metalloporphyrins -- chemical synthesis KW - Metalloporphyrins -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66682583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+journal+of+radiology&rft.atitle=Synthesis+of+copper+octabromotetracarboranylphenylporphyrin+for+boron+neutron+capture+therapy+and+its+toxicity+and+biodistribution+in+tumour-bearing+mice.&rft.au=Miura%2C+M%3BMorris%2C+G+M%3BMicca%2C+P+L%3BNawrocky%2C+M+M%3BMakar%2C+M+S%3BCook%2C+S+P%3BSlatkin%2C+D+N&rft.aulast=Miura&rft.aufirst=M&rft.date=2004-07-01&rft.volume=77&rft.issue=919&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=The+British+journal+of+radiology&rft.issn=00071285&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-30 N1 - Date created - 2004-07-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Saharan dust aerosol radiative forcing measured from space AN - 51503020; 2007-007033 JF - Journal of Climate AU - Li, F AU - Vogelmann, A M AU - Ramanathan, V Y1 - 2004/07// PY - 2004 DA - July 2004 SP - 2558 EP - 2571 PB - American Meteorological Society, Boston, MA VL - 17 IS - 13 SN - 0894-8755, 0894-8755 KW - monthly variations KW - clastic sediments KW - CERES KW - environmental analysis KW - physical properties KW - atmospheric transport KW - dust KW - sediments KW - Africa KW - aerosols KW - Sahara KW - diurnal variations KW - wind transport KW - chemical composition KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51503020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Climate&rft.atitle=Saharan+dust+aerosol+radiative+forcing+measured+from+space&rft.au=Li%2C+F%3BVogelmann%2C+A+M%3BRamanathan%2C+V&rft.aulast=Li&rft.aufirst=F&rft.date=2004-07-01&rft.volume=17&rft.issue=13&rft.spage=2558&rft.isbn=&rft.btitle=&rft.title=Journal+of+Climate&rft.issn=08948755&rft_id=info:doi/ L2 - http://journals.ametsoc.org/loi/clim LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 34 N1 - PubXState - MA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; Africa; atmospheric transport; CERES; chemical composition; clastic sediments; diurnal variations; dust; environmental analysis; monthly variations; physical properties; Sahara; sediments; wind transport ER - TY - JOUR T1 - Structural effects of radiation damage and its potential for phasing. AN - 71936402; 15159568 AB - A detailed analysis of radiation-damage-induced structural and intensity changes is presented on the model protein thaumatin. Changes in reflection intensities induced by irradiation display a parabolic character. The most pronounced structural changes observed were disulfide-bond breakage and associated main-chain and side-chain movements as well as decarboxylation of aspartate and glutamate residues. The structural changes induced on the sulfur atoms were successfully used to obtain high-quality phase estimates via an RIP procedure. Results obtained with ACORN suggest that the contribution originating from the partial structure may play an important role in phasing even at less than atomic resolution. JF - Acta crystallographica. Section D, Biological crystallography AU - Banumathi, Sankaran AU - Zwart, Petrus H AU - Ramagopal, Udupi A AU - Dauter, Miroslawa AU - Dauter, Zbigniew AD - Synchotron Radiation Research Section, MCL, National Cancer Institute, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2004/06// PY - 2004 DA - June 2004 SP - 1085 EP - 1093 VL - 60 SN - 0907-4449, 0907-4449 KW - Plant Proteins KW - 0 KW - Aspartic Acid KW - 30KYC7MIAI KW - Glutamic Acid KW - 3KX376GY7L KW - thaumatin protein, plant KW - 53850-34-3 KW - Sulfur KW - 70FD1KFU70 KW - Index Medicus KW - X-Ray Diffraction KW - Models, Molecular KW - Glutamic Acid -- chemistry KW - Models, Statistical KW - Sulfur -- chemistry KW - Aspartic Acid -- chemistry KW - Protein Conformation KW - Models, Theoretical KW - Plant Proteins -- chemistry KW - Radiation Effects KW - Crystallography, X-Ray -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71936402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Structural+effects+of+radiation+damage+and+its+potential+for+phasing.&rft.au=Banumathi%2C+Sankaran%3BZwart%2C+Petrus+H%3BRamagopal%2C+Udupi+A%3BDauter%2C+Miroslawa%3BDauter%2C+Zbigniew&rft.aulast=Banumathi&rft.aufirst=Sankaran&rft.date=2004-06-01&rft.volume=60&rft.issue=&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-01-31 N1 - Date created - 2004-05-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Biodistribution of Radioiodinated Adenovirus Fiber Protein Knob Domain after Intravenous Injection in Mice AN - 17978181; 5917797 AB - The knob domains from the fiber proteins of adenovirus serotypes 2 and 12 were labeled with radioiodine and then injected into the bloodstreams of mice. Knob proteins with functional binding sites for the coxsackie and adenovirus receptor (CAR) were cleared rapidly from the circulation, with radioactivity appearing predominantly in the stomach, while knob mutants unable to bind to CAR remained in the blood circulation for a prolonged period. The clearance of radiolabeled wild-type knob from the blood was slowed by coinjecting an excess of unlabeled wild-type knob protein. An earlier study showed that super(99m)Tc- labeled knob protein with intact CAR-binding activity also cleared rapidly from the blood circulation of mice, with radioactivity accumulating predominantly in the liver (K. R. Zinn et al., Gene Ther. 5:798-808, 1998). Together these results suggest that rapid clearance of knob protein from the blood results from specific binding to CAR in the liver and that the bound knob then enters a degradative pathway. The elevated levels of radioiodine in the stomach observed in our experiments are consistent with deiodination of labeled knob by dehalogenases in hepatocyte microsomes and uptake of the resultant free radioiodine by Na/I symporters in the gastric mucosa. Although CAR has been shown to localize in tight junctions of polarized epithelial cells, where it functions in intercellular adhesion, the results of our study suggest that a subset of CAR molecules in the liver is highly accessible to ligands in the blood and able to rapidly deliver bound ligand to an intracellular degradative compartment. JF - Journal of Virology AU - Awasthi, V AU - Meinken, G AU - Springer, K AU - Srivastava, S C AU - Freimuth, P AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, freimuth@bnl.gov Y1 - 2004/06// PY - 2004 DA - Jun 2004 SP - 6431 EP - 6438 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 78 IS - 12 SN - 0022-538X, 0022-538X KW - knob proteins KW - fiber proteins KW - intravenous administration KW - mice KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Radioiodination KW - Adenovirus KW - V 22150:Animal models & experimentally-induced viral infections KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17978181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Biodistribution+of+Radioiodinated+Adenovirus+Fiber+Protein+Knob+Domain+after+Intravenous+Injection+in+Mice&rft.au=Awasthi%2C+V%3BMeinken%2C+G%3BSpringer%2C+K%3BSrivastava%2C+S+C%3BFreimuth%2C+P&rft.aulast=Awasthi&rft.aufirst=V&rft.date=2004-06-01&rft.volume=78&rft.issue=12&rft.spage=6431&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.78.12.6431-6438.2004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adenovirus; Radioiodination DO - http://dx.doi.org/10.1128/JVI.78.12.6431-6438.2004 ER - TY - JOUR T1 - Structural Analysis of Botulinum Neurotoxin Type E Catalytic Domain and Its Mutant Glu212 arrow right Gln Reveals the Pivotal Role of the Glu212 Carboxylate in the Catalytic Pathway AN - 17820225; 5936596 AB - The seven serotypes of botulinum neurotoxins (A-G) produced by Clostridium botulinum share significant sequence homology and structural similarity. The functions of their individual domains and the modes of action are also similar. However, the substrate specificity and the peptide bond cleavage selectivity of their catalytic domains are different. The reason for this unique specificity of botulinum neurotoxins is still baffling. If an inhibitor leading to a therapeutic drug common to all serotypes is to be developed, it is essential to understand the differences in their three-dimensional structures that empower them with this unique characteristic. Accordingly, high-resolution structures of all serotypes are required, and toward achieving this goal the crystal structure of the catalytic domain of C. botulinum neurotoxin type E has been determined to 2.1 AA resolution. The crystal structure of the inactive mutant Glu212 arrow right Gln of this protein has also been determined. While the overall conformation is unaltered in the active site, the position of the nucleophilic water changes in the mutant, thereby causing it to lose its ability to activate the catalytic reaction. The structure explains the importance of the nucleophilic water and the charge on Glu212. The structural differences responsible for the loss of activity of the mutant provide a common model for the catalytic pathway of Clostridium neurotoxins since Glu212 is conserved and has a similar role in all serotypes. This or a more nonconservative mutant (e.g., Glu212 arrow right Ala) could provide a novel, genetically modified protein vaccine for botulinum. JF - Biochemistry (Washington) AU - Agarwal, R AU - Eswaramoorthy, S AU - Kumaran, D AU - Binz, T AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA Y1 - 2004/06/01/ PY - 2004 DA - 2004 Jun 01 SP - 6637 EP - 6644 VL - 43 IS - 21 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - Serotypes KW - Crystal structure KW - Substrate specificity KW - Vaccines KW - Clostridium botulinum KW - Neurotoxins KW - Drugs KW - Models KW - J 02822:Biosynthesis and physicochemical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17820225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+Analysis+of+Botulinum+Neurotoxin+Type+E+Catalytic+Domain+and+Its+Mutant+Glu212+arrow+right+Gln+Reveals+the+Pivotal+Role+of+the+Glu212+Carboxylate+in+the+Catalytic+Pathway&rft.au=Agarwal%2C+R%3BEswaramoorthy%2C+S%3BKumaran%2C+D%3BBinz%2C+T%3BSwaminathan%2C+S&rft.aulast=Agarwal&rft.aufirst=R&rft.date=2004-06-01&rft.volume=43&rft.issue=21&rft.spage=6637&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi036278w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clostridium botulinum; Neurotoxins; Serotypes; Crystal structure; Vaccines; Drugs; Substrate specificity; Models DO - http://dx.doi.org/10.1021/bi036278w ER - TY - JOUR T1 - Radiation dosimetry of a graphite moderated radium-beryllium source. AN - 71804080; 15069300 AB - The Brookhaven National Laboratory Sigma Pile is a radium-beryllium neutron source imbedded in a cube of graphite blocks. The pile is approximately 2.13 m on four sides and is 3.07 m high. Thermoluminescent dosimeters were used to determine the neutron and gamma-ray dose rates in the pile. Gamma-ray dose rate measurements have also been made in the air outside of the pile, while the radium-beryllium neutron source was being withdrawn from the pile. The Monte Carlo code has been used to calculate the coupled neutron-photon transport. Measured dose rates at various locations agreed with the calculated values within 5% to 15%. JF - Health physics AU - Holden, Norman E AU - Reciniello, Richard N AU - Hu, Jih-Perng AD - National Nuclear Data Center, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. holden@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - S110 EP - S112 VL - 86 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Radioisotopes KW - 0 KW - Graphite KW - 7782-42-5 KW - Beryllium KW - OW5102UV6N KW - Radium KW - W90AYD6R3Q KW - Index Medicus KW - Neutrons KW - Radiation Dosage KW - Radiometry -- instrumentation KW - Gamma Rays KW - Body Burden KW - Radioisotopes -- analysis KW - Radiometry -- methods KW - Thermoluminescent Dosimetry -- methods KW - Thermoluminescent Dosimetry -- instrumentation KW - Radiation Protection -- methods KW - Algorithms KW - Radium -- analysis KW - Risk Assessment -- methods KW - Beryllium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71804080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Radiation+dosimetry+of+a+graphite+moderated+radium-beryllium+source.&rft.au=Holden%2C+Norman+E%3BReciniello%2C+Richard+N%3BHu%2C+Jih-Perng&rft.aulast=Holden&rft.aufirst=Norman&rft.date=2004-05-01&rft.volume=86&rft.issue=5+Suppl&rft.spage=S110&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-21 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Optimization of the epithermal neutron beam for Boron Neutron Capture Therapy at the Brookhaven Medical Research Reactor. AN - 71802751; 15069299 AB - The use of epithermal neutron beam in clinical trials of Boron Neutron Capture Therapy for patients with malignant brain tumors had been carried out for half a decade at the Brookhaven's Medical Reactor. The decision to permanently close this reactor in 2000 cut short the efforts to implement a new conceptual design to optimize this beam in preparation for use with possible new BNCT protocols. Details of the conceptual design to produce a highly intensified and focused neutron beam with less gamma and neutron contamination in tissues are presented here for their potential applicability to other reactor facilities. Neutron-photon coupled Monte Carlo calculations were used to predict the flux, current, heating, and absorbed dose produced by the proposed design. The results were benchmarked by the dose rate and flux measurements taken at the facility then in use. JF - Health physics AU - Hu, Jih-Perng AU - Reciniello, Richard N AU - Holden, Norman E AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA. hu1@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - S103 EP - S109 VL - 86 IS - 5 Suppl SN - 0017-9078, 0017-9078 KW - Index Medicus KW - New York KW - Computer Simulation KW - Radiotherapy Dosage KW - Humans KW - Academies and Institutes KW - Models, Statistical KW - Computer-Aided Design KW - Quality Control KW - Boron Neutron Capture Therapy -- instrumentation KW - Radiation Protection -- methods KW - Neoplasms -- radiotherapy KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Equipment Failure Analysis -- methods KW - Boron Neutron Capture Therapy -- methods KW - Radiometry -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71802751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Optimization+of+the+epithermal+neutron+beam+for+Boron+Neutron+Capture+Therapy+at+the+Brookhaven+Medical+Research+Reactor.&rft.au=Hu%2C+Jih-Perng%3BReciniello%2C+Richard+N%3BHolden%2C+Norman+E&rft.aulast=Hu&rft.aufirst=Jih-Perng&rft.date=2004-05-01&rft.volume=86&rft.issue=5+Suppl&rft.spage=S103&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-21 N1 - Date created - 2004-04-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Engineered endophytic bacteria improve phytoremediation of water-soluble, volatile, organic pollutants AN - 18051779; 5916953 AB - Phytoremediation of highly water soluble and volatile organic xenobiotics is often inefficient because plants do not completely degrade these compounds through their rhizospheres. This results in phytotoxicity and/or volatilization of chemicals through the leaves, which can cause additional environmental problems. We demonstrate that endophytic bacteria equipped with the appropriate degradation pathway improve the in planta degradation of toluene. We introduced the pTOM toluene-degradation plasmid of Burkholderia cepacia G4 into B. cepacia L.S.2.4, a natural endophyte of yellow lupine. After surface-sterilized lupine seeds were successfully inoculated with the recombinant strain, the engineered endophytic bacteria strongly degraded toluene, resulting in a marked decrease in its phytotoxicity, and a 50-70% reduction of its evapotranspiration through the leaves. This strategy promises to improve the efficiency of phytoremediating volatile organic contaminants. JF - Nature Biotechnology AU - Barac, T AU - Taghavi, S AU - Borremans, B AU - Provoost, A AU - Oeyen, L AU - Colpaert, J V AU - Vangronsveld, J AU - van der Lelie, D AD - Flemish Institute for Technological Research (VITO), Environmental Technology Expertise Center, Boeretang 200, B-2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2004/05// PY - 2004 DA - May 2004 SP - 583 EP - 588 VL - 22 IS - 5 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Biodegradation KW - Toluene KW - Rhizosphere KW - Xenobiotics KW - Burkholderia cepacia KW - Pollutants KW - phytoremediation KW - Seeds KW - Endophytes KW - Leaves KW - Volatilization KW - Evapotranspiration KW - Plasmids KW - Volatiles KW - Phytotoxicity KW - Contaminants KW - W2 32510:Waste treatment, environment, pollution KW - W 30965:Miscellaneous, Reviews KW - W4 210:Bioremediation, Bioreactors & BioCycling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18051779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Engineered+endophytic+bacteria+improve+phytoremediation+of+water-soluble%2C+volatile%2C+organic+pollutants&rft.au=Barac%2C+T%3BTaghavi%2C+S%3BBorremans%2C+B%3BProvoost%2C+A%3BOeyen%2C+L%3BColpaert%2C+J+V%3BVangronsveld%2C+J%3Bvan+der+Lelie%2C+D&rft.aulast=Barac&rft.aufirst=T&rft.date=2004-05-01&rft.volume=22&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Burkholderia cepacia; Rhizosphere; Endophytes; Volatiles; Phytotoxicity; Biodegradation; phytoremediation; Leaves; Toluene; Seeds; Volatilization; Xenobiotics; Evapotranspiration; Pollutants; Plasmids; Contaminants DO - http://dx.doi.org/10.1038/nbt960 ER - TY - JOUR T1 - Thermodynamic Studies of the Mechanism of Metal Binding to the Escherichia coli Zinc Transporter YiiP AN - 18048225; 5881055 AB - Sequence homology of the Escherichia coli YiiP places it within the family of cation diffusion facilitators, a family of membrane transporters that play a central role in regulating cellular zinc homeostasis. Here we describe the first thermodynamic and mechanistic studies of metal binding to a cation diffusion facilitator. Isothermal titration calorimetric analyses of the purified YiiP and binding competitions among Zn super(2+), Cd super(2+), and Hg super(2+) revealed a mutually competitive binding site common to three metal ions and a set of noncompetitive binding sites, including one Cd super(2+) site, one Hg super(2+) site, and at least one Zn super(2+) site, to which the binding of Zn super(2+) exhibited partial inhibitions of both Cd super(2+) and Hg super(2+) bindings. Lowering the pH from 7.0 to 5.5 inhibited binding of Zn super(2+) and Cd super(2+) to the common site. Further, the enthalpy change of the Cd super(2+) binding to the common site was found to be related linearly to the ionization enthalpy of the pH buffer with a slope corresponding to the release of 1.23 H super(+) for each Cd super(2+) binding. These H super(+) effects are consistent with a coupled deprotonation process upon binding of Zn super(2+) and Cd super(2+). Modification of histidine residues by diethyl pyrocarbonate specifically inhibited Zn super(2+) binding to the common binding site, indicating that the mechanism of binding-deprotonation coupling involves a histidine residue(s). JF - Journal of Biological Chemistry AU - Chao, Y AU - Fu, D AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, dax@bnl.gov Y1 - 2004/04/23/ PY - 2004 DA - 2004 Apr 23 SP - 17173 EP - 17180 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 17 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Membranes KW - Thermodynamics KW - Transport KW - Zinc KW - Escherichia coli KW - Mercury KW - Homeostasis KW - Copper KW - Mechanisms KW - Modification KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18048225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Thermodynamic+Studies+of+the+Mechanism+of+Metal+Binding+to+the+Escherichia+coli+Zinc+Transporter+YiiP&rft.au=Chao%2C+Y%3BFu%2C+D&rft.aulast=Chao&rft.aufirst=Y&rft.date=2004-04-23&rft.volume=279&rft.issue=17&rft.spage=17173&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M400208200 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Membranes; Thermodynamics; Transport; Zinc; Mercury; Copper; Homeostasis; Mechanisms; Modification; Escherichia coli DO - http://dx.doi.org/10.1074/jbc.M400208200 ER - TY - JOUR T1 - A second life in science--working after the age of 65. AN - 71723123; 15010320 AB - I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuations of ones begun before the age of 65 (1986) and several new ones were based on both previous interests and ideas and some on new ideas. A number of the ideas arose from participation on Committees of the US National Research Council. I was able to extend my earlier interests in DNA repair to include experiments on the variations in DNA repair among apparently normal humans. In collaborations with other researchers we showed that the repair abilities following exposures to chemicals or to ionizing or ultraviolet (UV) radiation did not follow Poisson distributions. I participated in experiments, using a fish model to estimate the wavelength ranges in sunlight responsible for inducing melanoma and another fish model to estimate the germ cell mutations that might arise from exposures to the heavily ionizing particles in cosmic rays beyond low Earth orbit. A transgenic fish model was used to investigate the possibilities of using the fish to assay for mutagens in sediments in Long Island Sound. These Reflections summarize the atmosphere necessary for a second life and the scientific results of this life. JF - DNA repair AU - Setlow, Richard B AD - Biology Department, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA. setlow@bnl.gov Y1 - 2004/04/01/ PY - 2004 DA - 2004 Apr 01 SP - 441 EP - 449 VL - 3 IS - 4 SN - 1568-7864, 1568-7864 KW - Index Medicus KW - United States KW - Animals KW - History, 20th Century KW - DNA Repair KW - Melanoma -- etiology KW - Humans KW - Neoplasms, Radiation-Induced KW - Radiation Tolerance KW - Aged KW - Biology KW - Employment -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71723123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=A+second+life+in+science--working+after+the+age+of+65.&rft.au=Setlow%2C+Richard+B&rft.aulast=Setlow&rft.aufirst=Richard&rft.date=2004-04-01&rft.volume=3&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-12-08 N1 - Date created - 2004-03-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sunlight transmission through desert dust and marine aerosols; diffuse light corrections to Sun photometry and pyrheliometry AN - 51808679; 2004-064188 JF - Journal of Geophysical Research AU - Russell, P B AU - Livingston, J M AU - Dubovik, O AU - Ramirez, S A AU - Wang, J AU - Redemann, J AU - Schmid, B AU - Box, M AU - Holben, B N Y1 - 2004/04// PY - 2004 DA - April 2004 SP - 13 PB - American Geophysical Union, Washington, DC VL - 109 IS - D8 SN - 0148-0227, 0148-0227 KW - terrestrial environment KW - clastic sediments KW - pyrheliometry KW - equations KW - photometry KW - optical properties KW - marine environment KW - mathematical methods KW - dust KW - solar radiation KW - sediments KW - aerosols KW - propagation KW - corrections KW - light KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51808679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Sunlight+transmission+through+desert+dust+and+marine+aerosols%3B+diffuse+light+corrections+to+Sun+photometry+and+pyrheliometry&rft.au=Russell%2C+P+B%3BLivingston%2C+J+M%3BDubovik%2C+O%3BRamirez%2C+S+A%3BWang%2C+J%3BRedemann%2C+J%3BSchmid%2C+B%3BBox%2C+M%3BHolben%2C+B+N&rft.aulast=Russell&rft.aufirst=P&rft.date=2004-04-01&rft.volume=109&rft.issue=D8&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2003JD004292 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 56 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - SuppNotes - Includes appendix N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; clastic sediments; corrections; dust; equations; light; marine environment; mathematical methods; optical properties; photometry; propagation; pyrheliometry; sediments; solar radiation; terrestrial environment DO - http://dx.doi.org/10.1029/2003JD004292 ER - TY - JOUR T1 - Kinetic Study of the Antiport Mechanism of an Escherichia coli Zinc Transporter, ZitB AN - 18035646; 5860678 AB - ZitB is a member of the cation diffusion facilitator (CDF) family that mediates efflux of zinc across the plasma membrane of Escherichia coli. We describe the first kinetic study of the purified and reconstituted ZitB by stopped-flow measurements of transmembrane fluxes of metal ions using a metal- sensitive fluorescent indicator encapsulated in proteoliposomes. Metal ion filling experiments showed that the initial rate of Zn super(2+) influx was a linear function of the molar ratio of ZitB to lipid and was related to the concentration of Zn super(2+) or Cd super(2+) by a hyperbola with a Michaelis-Menten constant (K sub(m)) of 104.9 plus or minus 5.4 mu M and 90.1 plus or minus 3.7 mu M, respectively. Depletion of proton stalled Cd super(2+) transport down its diffusion gradient, whereas tetraethylammonium ion substitution for K super(+) did not affect Cd super(2+) transport, indicating that Cd super(2+) transport is coupled to H super(+) rather than to K super(+). H super(+) transport was inferred by the H super(+) dependence of Cd super(2+) transport, showing a hyperbolic relationship with a K sub(m) of 19.9 nM for H super(+). Applying H super(+) diffusion gradients across the membrane caused Cd super(2+) fluxes both into and out of proteoliposomes against the imposed H super(+) gradients. Likewise, applying outwardly oriented membrane electrical potential resulted in Cd super(2+) efflux, demonstrating the electrogenic effect of ZitB transport. Taken together, these results indicate that ZitB is an antiporter catalyzing the obligatory exchange of Zn super(2+) or Cd super(2+) for H super(+). The exchange stoichiometry of metal ion for proton is likely to be 1:1. JF - Journal of Biological Chemistry AU - Chao, Y AU - Fu, D AD - Department of Biology, Brookhaven National Laboratory, Upton, New York 11973, dax@bnl.gov Y1 - 2004/03/26/ PY - 2004 DA - 2004 Mar 26 SP - 12043 EP - 12050 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 279 IS - 13 SN - 0021-9258, 0021-9258 KW - proteoliposomes KW - Microbiology Abstracts B: Bacteriology KW - Fluorescence KW - Metal ions KW - Depletion KW - Protons KW - Efflux KW - Lipids KW - Gradients KW - Encapsulation KW - Plasma membranes KW - Flux KW - Zinc KW - Escherichia coli KW - Stoichiometry KW - Tetraethylammonium KW - J 02721:Cell cycle, morphology and motility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18035646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Kinetic+Study+of+the+Antiport+Mechanism+of+an+Escherichia+coli+Zinc+Transporter%2C+ZitB&rft.au=Chao%2C+Y%3BFu%2C+D&rft.aulast=Chao&rft.aufirst=Y&rft.date=2004-03-26&rft.volume=279&rft.issue=13&rft.spage=12043&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/10.1074%2Fjbc.M313510200 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Fluorescence; Metal ions; Protons; Depletion; Lipids; Efflux; Gradients; Encapsulation; Plasma membranes; Flux; Zinc; Stoichiometry; Tetraethylammonium; Escherichia coli DO - http://dx.doi.org/10.1074/jbc.M313510200 ER - TY - JOUR T1 - Role of metals in the biological activity of Clostridium botulinum neurotoxins. AN - 80181038; 14979717 AB - Clostridium botulinum neurotoxins are the most potent toxins to humans and cause paralysis by blocking neurotransmitter release at the presynaptic nerve terminals. The toxicity involves four steps, viz., binding to neuronal cells, internalization, translocation, and catalytic activity. While the catalytic activity is a zinc endopeptidase activity on the SNARE complex proteins, the translocation is believed to be a pH-dependent process allowing the translocation domain to change its conformation to penetrate the endosomal membrane. Here, we report the crystal structures of botulinum neurotoxin type B at various pHs and of an apo form of the neurotoxin, and discuss the role of metal ions and the effect of pH variation in the biological activity. Except for the perturbation of a few side chains, the conformation of the catalytic domain is unchanged in the zinc-depleted apotoxin, suggesting that zinc's role is catalytic. We have also identified two calcium ions in the molecule and present biochemical evidence to show that they play a role in the translocation of the light chain through the membrane. JF - Biochemistry AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Keller, James AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2004/03/02/ PY - 2004 DA - 2004 Mar 02 SP - 2209 EP - 2216 VL - 43 IS - 8 SN - 0006-2960, 0006-2960 KW - Apoproteins KW - 0 KW - Cations, Divalent KW - Membrane Proteins KW - Metals, Heavy KW - Nerve Tissue Proteins KW - Snap25 protein, mouse KW - Synaptosomal-Associated Protein 25 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Zinc KW - J41CSQ7QDS KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Cytosol -- metabolism KW - Protein Structure, Secondary KW - Apoproteins -- chemistry KW - Calcium -- chemistry KW - Hydrogen-Ion Concentration KW - Membrane Proteins -- metabolism KW - Catalytic Domain KW - Mice KW - Zinc -- chemistry KW - Binding Sites KW - Cells, Cultured KW - Nerve Tissue Proteins -- metabolism KW - Crystallography, X-Ray KW - Cytosol -- microbiology KW - Cations, Divalent -- chemistry KW - Protein Transport KW - Protein Conformation KW - Botulinum Toxins, Type A -- metabolism KW - Botulinum Toxins -- chemistry KW - Metals, Heavy -- chemistry KW - Botulinum Toxins -- metabolism KW - Botulinum Toxins, Type A -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80181038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Role+of+metals+in+the+biological+activity+of+Clostridium+botulinum+neurotoxins.&rft.au=Eswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BKeller%2C+James%3BSwaminathan%2C+Subramanyam&rft.aulast=Eswaramoorthy&rft.aufirst=Subramaniam&rft.date=2004-03-02&rft.volume=43&rft.issue=8&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-06-29 N1 - Date created - 2004-02-24 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1S0D; PDB; 1S0E; 1S0B; 1S0C; 1S0F; 1S0G N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Structure and enzymatic activity of botulinum neurotoxins. AN - 85376708; pmid-15027050 AB - The structure of botulinum neurotoxin type B (BoNT/B) is analyzed, and it is demonstrated that the carbonyl oxygen of the scissile bond comes close to the zinc ion to form a Michaelis complex. The hydrated carbonyl is activated by the nucleophilic water, which moves closer to Glu 230 to form hydrogen bonds to side-chain carboxylate. This process frees up the lone pair, which forms a bond with carbonyl carbon, corresponding to the tetrahedral transition state. The hydrated peptide oxygen is stabilized by a zinc ion and a water molecule close by. The proton from the nucleophile moves to NH of the scissile bond. The other proton is shuttled by Glu 230 to the NH2 group to make it NH3+ and allows it to leave. This mechanism is consistent with that proposed for thermolysin and BoNT/A. On the basis of these studies, we have shown that Tyr372 or Arg369 may not have any significant role in catalytic activity except for a secondary role such as stabilizing the transition state. Thus, the sulfate ion mimics the transition state of the scissile carbonyl carbon atom. However, the sulfate ion by itself does not inhibit the toxicity. JF - Movement disorders : official journal of the Movement Disorder Society AU - Swaminathan, Subramanyam AU - Eswaramoorthy, Subramanian AU - Kumaran, Desigan AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. swami@bnl.gov Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - S17 EP - S22 VL - 19 Suppl 8 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - *Botulinum Toxins: chemistry KW - *Botulinum Toxins: metabolism KW - Crystallography, X-Ray: methods KW - *Hydrogen Bonding KW - Molecular Structure KW - Protein Conformation KW - Structure-Activity Relationship KW - Zinc: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85376708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Structure+and+enzymatic+activity+of+botulinum+neurotoxins.&rft.au=Swaminathan%2C+Subramanyam%3BEswaramoorthy%2C+Subramanian%3BKumaran%2C+Desigan&rft.aulast=Swaminathan&rft.aufirst=Subramanyam&rft.date=2004-03-01&rft.volume=19+Suppl+8&rft.issue=&rft.spage=S17&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cloning, high level expression, purification, and crystallization of the full length Clostridium botulinum neurotoxin type E light chain. AN - 80152535; 14766304 AB - The catalytic activity of the highly potent botulinum neurotoxins are confined to their N-terminal light chains ( approximately 50kDa). A full-length light chain for the type E neurotoxin with a C-terminal 6x His-tag, BoNT/E-LC, has been cloned in a pET-9c vector and over-expressed in BL21 (DE3) cells. BoNT/E-LC was purified to homogeneity by affinity chromatography on Ni-NTA agarose followed by exclusion chromatography using a Superdex-75 sizing column. The purified protein has very good solubility and can be stored stably at -20 degrees C; however, it seems to undergo auto-proteolysis when stored at temperature #10878;4-10 degrees C. BoNT/E-LC is active on its natural substrate, the synaptosomal associated 25kDa protein, SNAP-25, indicating that it retains a native-like conformation and therefore can be considered as a useful tool in studying the structure/function of the catalytic light chain. Recombinant BoNT/E-LC has been crystallized under five different conditions and at various pHs. Crystals diffract to better than 2.1A. JF - Protein expression and purification AU - Agarwal, Rakhi AU - Eswaramoorthy, Subramaniam AU - Kumaran, Desigan AU - Dunn, John J AU - Swaminathan, Subramanyam AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 95 EP - 102 VL - 34 IS - 1 SN - 1046-5928, 1046-5928 KW - Membrane Proteins KW - 0 KW - Nerve Tissue Proteins KW - Protein Subunits KW - Recombinant Fusion Proteins KW - Synaptosomal-Associated Protein 25 KW - Histidine KW - 4QD397987E KW - Botulinum Toxins KW - EC 3.4.24.69 KW - botulinum toxin type E KW - T579M564JY KW - Index Medicus KW - Recombinant Fusion Proteins -- biosynthesis KW - Electrophoresis, Polyacrylamide Gel KW - Recombinant Fusion Proteins -- isolation & purification KW - Escherichia coli -- genetics KW - Nerve Tissue Proteins -- biosynthesis KW - Membrane Proteins -- genetics KW - Clostridium botulinum -- enzymology KW - Recombinant Fusion Proteins -- chemistry KW - Chromatography, Gel KW - Membrane Proteins -- biosynthesis KW - Time Factors KW - Crystallization KW - Solubility KW - Membrane Proteins -- metabolism KW - Temperature KW - Nerve Tissue Proteins -- genetics KW - Cloning, Molecular KW - Chromatography, Affinity KW - Histidine -- genetics KW - Enzyme Stability KW - Kinetics KW - Nerve Tissue Proteins -- metabolism KW - Genetic Vectors -- genetics KW - Clostridium botulinum -- genetics KW - Catalysis KW - Protein Subunits -- genetics KW - Gene Expression -- genetics KW - Protein Subunits -- biosynthesis KW - Botulinum Toxins -- genetics KW - Botulinum Toxins -- biosynthesis KW - Protein Subunits -- metabolism KW - Botulinum Toxins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80152535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+expression+and+purification&rft.atitle=Cloning%2C+high+level+expression%2C+purification%2C+and+crystallization+of+the+full+length+Clostridium+botulinum+neurotoxin+type+E+light+chain.&rft.au=Agarwal%2C+Rakhi%3BEswaramoorthy%2C+Subramaniam%3BKumaran%2C+Desigan%3BDunn%2C+John+J%3BSwaminathan%2C+Subramanyam&rft.aulast=Agarwal&rft.aufirst=Rakhi&rft.date=2004-03-01&rft.volume=34&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Protein+expression+and+purification&rft.issn=10465928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-10-26 N1 - Date created - 2004-02-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Hydrolase activity, microbial biomass and community structure in long-term Cd-contaminated soils AN - 51828909; 2004-051259 JF - Soil Biology & Biochemistry AU - Renella, G AU - Mench, M AU - van der Lelie, D AU - Pietramellara, G AU - Ascher, J AU - Ceccherini, M T AU - Landi, L AU - Nannipieri, P Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 443 EP - 451 PB - Pergamon, Oxford VL - 36 IS - 3 SN - 0038-0717, 0038-0717 KW - soils KW - concentration KW - toxic materials KW - yields KW - biomass KW - pollutants KW - metabolism KW - electrophoresis KW - pollution KW - bioavailability KW - solubility KW - hydrolases KW - habitat KW - detection KW - metals KW - bacteria KW - cadmium KW - land use KW - activity KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51828909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soil+Biology+%26+Biochemistry&rft.atitle=Hydrolase+activity%2C+microbial+biomass+and+community+structure+in+long-term+Cd-contaminated+soils&rft.au=Renella%2C+G%3BMench%2C+M%3Bvan+der+Lelie%2C+D%3BPietramellara%2C+G%3BAscher%2C+J%3BCeccherini%2C+M+T%3BLandi%2C+L%3BNannipieri%2C+P&rft.aulast=Renella&rft.aufirst=G&rft.date=2004-03-01&rft.volume=36&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Soil+Biology+%26+Biochemistry&rft.issn=00380717&rft_id=info:doi/10.1016%2Fj.soilbio.2003.10.022 L2 - http://www.sciencedirect.com/science/journal/00380717 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 51 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - activity; bacteria; bioavailability; biomass; cadmium; concentration; detection; electrophoresis; habitat; hydrolases; land use; metabolism; metals; microorganisms; pollutants; pollution; soils; solubility; toxic materials; yields DO - http://dx.doi.org/10.1016/j.soilbio.2003.10.022 ER - TY - JOUR T1 - Ancient water on 4 Vesta Asteroid; evidence from a quartz veinlet in the Serra de Mage eucrite meteorite AN - 50272064; 2005-071173 AB - The meteorite Serra de Mage, a eucrite inferred to be from the asteroid 4 Vesta, contains quartz veinlets. They are identical to antitaxial or "crack-seal" quartz veinlets in terrestrial rocks, and are extraterrestrial and ancient because they pre-date a 4.40 Ga metamorphism. The quartz was likely deposited from liquid water solutions (as are terrestrial veins); other potential solvents or transport mechanisms are inadequate or unlikely. Because there is no indication of internal (magmatic) water in the eucrite meteorites and thus in Vesta, the water from which the veinlet was deposited probably came from outside Vesta. By analogy with water ice deposits on the Moon and Mercury, Vesta and similar asteroids may have had (or now have) polar ice deposits, possibly derived from comet impacts. JF - Earth and Planetary Science Letters AU - Treiman, Allan H AU - Lanzirotti, Antonio AU - Xirouchakis, Dimitrios Y1 - 2004/03// PY - 2004 DA - March 2004 SP - 189 EP - 199 PB - Elsevier, Amsterdam VL - 219 IS - 3-4 SN - 0012-821X, 0012-821X KW - silicates KW - stony meteorites KW - asteroids KW - X-ray diffraction data KW - electron probe data KW - meteorites KW - mineral composition KW - ice KW - Mercury Planet KW - Archean KW - chemical composition KW - geochemistry KW - Precambrian KW - Vesta Asteroid KW - Moon KW - textures KW - cosmochemistry KW - impacts KW - veins KW - metamorphism KW - achondrites KW - terrestrial planets KW - quartz veins KW - planets KW - Serra de Mage Meteorite KW - comets KW - petrography KW - eucrite KW - 05B:Petrology of meteorites and tektites KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50272064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+and+Planetary+Science+Letters&rft.atitle=Ancient+water+on+4+Vesta+Asteroid%3B+evidence+from+a+quartz+veinlet+in+the+Serra+de+Mage+eucrite+meteorite&rft.au=Treiman%2C+Allan+H%3BLanzirotti%2C+Antonio%3BXirouchakis%2C+Dimitrios&rft.aulast=Treiman&rft.aufirst=Allan&rft.date=2004-03-01&rft.volume=219&rft.issue=3-4&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Earth+and+Planetary+Science+Letters&rft.issn=0012821X&rft_id=info:doi/10.1016%2FS0012-821X%2804%2900004-4 L2 - http://www.sciencedirect.com/science/journal/0012821X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2005-01-01 N1 - Number of references - 50 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - CODEN - EPSLA2 N1 - SubjectsTermNotLitGenreText - achondrites; Archean; asteroids; chemical composition; comets; cosmochemistry; electron probe data; eucrite; geochemistry; ice; impacts; Mercury Planet; metamorphism; meteorites; mineral composition; Moon; petrography; planets; Precambrian; quartz veins; Serra de Mage Meteorite; silicates; stony meteorites; terrestrial planets; textures; veins; Vesta Asteroid; X-ray diffraction data DO - http://dx.doi.org/10.1016/S0012-821X(04)00004-4 ER - TY - JOUR T1 - A NRC-BNL benchmark evaluation of seismic analysis methods for non-classically damped coupled systems AN - 17994455; 5934753 AB - Under the auspices of the U.S. Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a comprehensive program to evaluate state-of-the-art methods and computer programs for seismic analysis of typical coupled nuclear power plant (NPP) systems with non-classical damping. In this program, four benchmark models of coupled building-piping/equipment systems with different damping characteristics were developed and analyzed by BNL for a suite of earthquakes. The BNL analysis was carried out by the Wilson- theta time domain integration method with the system-damping matrix computed using a synthesis formulation as presented in a companion paper [Nucl. Eng. Des. (2002)]. These benchmark problems were subsequently distributed to and analyzed by program participants applying their uniquely developed methods and computer programs. This paper is intended to offer a glimpse at the program, and provide a summary of major findings and principle conclusions with some representative results. The participant's analysis results established using complex modal time history methods showed good comparison with the BNL solutions, while the analyses produced with either complex-mode response spectrum methods or classical normal-mode response spectrum method, in general, produced more conservative results, when averaged over a suite of earthquakes. However, when coupling due to damping is significant, complex-mode response spectrum methods performed better than the classical normal-mode response spectrum method. Furthermore, as part of the program objectives, a parametric assessment is also presented in this paper, aimed at evaluation of the applicability of various analysis methods to problems with different dynamic characteristics unique to coupled NPP systems. It is believed that the findings and insights learned from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving license applications of these alternate methods to coupled systems. JF - Nuclear Engineering and Design AU - Xu, J AU - DeGrassi, G AU - Chokshi, N AD - Brookhaven National Laboratory, Upton, NY 11973-5000, USA Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 345 EP - 366 VL - 228 IS - 1-3 SN - 0029-5493, 0029-5493 KW - damping KW - Health & Safety Science Abstracts KW - Earthquakes KW - Nuclear power plants KW - Structural analysis KW - Seismic activity KW - Computer applications KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17994455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=A+NRC-BNL+benchmark+evaluation+of+seismic+analysis+methods+for+non-classically+damped+coupled+systems&rft.au=Xu%2C+J%3BDeGrassi%2C+G%3BChokshi%2C+N&rft.aulast=Xu&rft.aufirst=J&rft.date=2004-03-01&rft.volume=228&rft.issue=1-3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/10.1016%2Fj.nucengdes.2003.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Computer applications; Structural analysis; Nuclear power plants; Earthquakes; Seismic activity DO - http://dx.doi.org/10.1016/j.nucengdes.2003.06.019 ER - TY - JOUR T1 - Degradation assessment of structures and passive components at nuclear power plants AN - 17986258; 5934750 AB - This paper describes a multi-year research program to assess age-related degradation of structures and passive components important to the safe operation of nuclear power plants (NPPs). The purpose of the research effort is to develop the technical basis for the validation and improvement of analytical methods and acceptance criteria which can be used to make risk-informed decisions and to address technical issues related to degradation of structures and passive components. The approach adopted for this research program consists of two phases. In Phase I, specific degradation occurrences at plants were collected and evaluated, existing technical information on aging was reviewed, and a scoping study was performed to identify which structures and components should be studied in the subsequent phases of the research program. Based on the results of the Phase I effort, selected structures and passive components are evaluated in Phase II to assess the effects of age-related degradation using existing and enhanced analytical methods. Fragility analyses are performed for undegraded and degraded structures and passive components. These results can then be used to assess the potential impact of degradation on overall plant risk. The Phase II effort also utilizes the results of the analyses to develop probabilistic degradation acceptance criteria for the structures and passive components studied. These research activities provide useful tools to support the current goals of developing risk-informed and performance-based regulation in the nuclear industry. JF - Nuclear Engineering and Design AU - Braverman, JI AU - Miller, CA AU - Hofmayer, CH AU - Ellingwood, B R AU - Naus, D J AU - Chang, TY AD - Brookhaven National Laboratory, Building 130, P.O. Box 5000, Upton, NY, USA Y1 - 2004/03// PY - 2004 DA - Mar 2004 SP - 283 EP - 304 VL - 228 IS - 1-3 SN - 0029-5493, 0029-5493 KW - Health & Safety Science Abstracts; Risk Abstracts KW - decision making KW - Nuclear power plants KW - service life KW - aging KW - R2 23020:Technological risks KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17986258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Engineering+and+Design&rft.atitle=Degradation+assessment+of+structures+and+passive+components+at+nuclear+power+plants&rft.au=Braverman%2C+JI%3BMiller%2C+CA%3BHofmayer%2C+CH%3BEllingwood%2C+B+R%3BNaus%2C+D+J%3BChang%2C+TY&rft.aulast=Braverman&rft.aufirst=JI&rft.date=2004-03-01&rft.volume=228&rft.issue=1-3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Nuclear+Engineering+and+Design&rft.issn=00295493&rft_id=info:doi/10.1016%2Fj.nucengdes.2003.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - aging; service life; Nuclear power plants; decision making DO - http://dx.doi.org/10.1016/j.nucengdes.2003.06.012 ER - TY - JOUR T1 - Partial recovery of brain metabolism in methamphetamine abusers after protracted abstinence. AN - 80140719; 14754772 AB - OBJECTIVEMethamphetamine is a highly addictive drug of abuse that is neurotoxic to dopamine terminals. The authors recently reported that decreases in dopamine transporters (used as markers of dopamine terminals) in the striatum of methamphetamine abusers recover with protracted abstinence and that relative to comparison subjects, recently detoxified methamphetamine abusers have lower metabolism in the striatum and thalamus. In this study, the authors assessed whether metabolism recovers with protracted abstinence.METHODBrain glucose metabolism was measured with positron emission tomography and [18F]fluorodeoxyglucose in five methamphetamine abusers who were evaluated after both a short (<6 months) and protracted (12-17 months) abstinence interval, eight methamphetamine abusers tested only after protracted abstinence, and 11 comparison subjects who were not drug users.RESULTSSignificantly greater thalamic, but not striatal, metabolism was seen following protracted abstinence relative to metabolism assessed after a short abstinence interval, and this increase was associated with improved performance in motor and verbal memory tests. Relative to the comparison subjects, the methamphetamine abusers tested after protracted abstinence had lower metabolism in the striatum (most accentuated in the caudate and nucleus accumbens) but not in the thalamus.CONCLUSIONSThe persistent decreases in striatal metabolism in methamphetamine abusers could reflect long-lasting changes in dopamine cell activity, and decreases in the nucleus accumbens could account for the persistence of amotivation and anhedonia in detoxified methamphetamine abusers. The recovery of thalamic metabolism could reflect adaptation responses to compensate for the dopamine deficits, and the associated improvement in neuropsychological performance further indicates its functional significance. These results suggest that while protracted abstinence may reverse some of the methamphetamine-induced alterations in brain function, other deficits persist. JF - The American journal of psychiatry AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Chang, Linda AU - Miller, Eric AU - Sedler, Mark AU - Hitzemann, Robert AU - Zhu, Wei AU - Logan, Jean AU - Ma, Yeming AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 242 EP - 248 VL - 161 IS - 2 SN - 0002-953X, 0002-953X KW - Radiopharmaceuticals KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Cognition Disorders -- diagnosis KW - Corpus Striatum -- metabolism KW - Humans KW - Thalamus -- metabolism KW - Corpus Striatum -- physiopathology KW - Adult KW - Tomography, Emission-Computed KW - Thalamus -- physiopathology KW - Adaptation, Physiological KW - Neuropsychological Tests KW - Time Factors KW - Female KW - Male KW - Brain -- physiopathology KW - Amphetamine-Related Disorders -- prevention & control KW - Amphetamine-Related Disorders -- metabolism KW - Recovery of Function KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Presynaptic Terminals -- metabolism KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/80140719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Partial+recovery+of+brain+metabolism+in+methamphetamine+abusers+after+protracted+abstinence.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BChang%2C+Linda%3BMiller%2C+Eric%3BSedler%2C+Mark%3BHitzemann%2C+Robert%3BZhu%2C+Wei%3BLogan%2C+Jean%3BMa%2C+Yeming%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-02-01&rft.volume=161&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-04-01 N1 - Date created - 2004-02-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment In: Am J Psychiatry. 2004 Feb;161(2):193-4 [14754764] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Anisotropic compression of edingtonite and thomsonite to 6 GPa at room temperature AN - 51499569; 2007-007280 JF - Physics and Chemistry of Minerals AU - Lee, Y AU - Hriljac, J A AU - Studer, A AU - Vogt, T Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 22 EP - 27 PB - Springer-Verlag, Berlin - New York VL - 31 IS - 1 SN - 0342-1791, 0342-1791 KW - silicates KW - pressure KW - X-ray diffraction data KW - statistical analysis KW - unit cell KW - crystal structure KW - elastic constants KW - edingtonite KW - bulk modulus KW - high pressure KW - least-squares analysis KW - thomsonite KW - zeolite group KW - framework silicates KW - compression KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51499569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physics+and+Chemistry+of+Minerals&rft.atitle=Anisotropic+compression+of+edingtonite+and+thomsonite+to+6+GPa+at+room+temperature&rft.au=Lee%2C+Y%3BHriljac%2C+J+A%3BStuder%2C+A%3BVogt%2C+T&rft.aulast=Lee&rft.aufirst=Y&rft.date=2004-02-01&rft.volume=31&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Physics+and+Chemistry+of+Minerals&rft.issn=03421791&rft_id=info:doi/10.1007%2Fs00269-003-0330-6 L2 - http://www.springerlink.com/content/100449/?p=e597e977f1914094b3810f7e67f0a453&pi=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 31 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - PCMIDU N1 - SubjectsTermNotLitGenreText - bulk modulus; compression; crystal structure; edingtonite; elastic constants; framework silicates; high pressure; least-squares analysis; pressure; silicates; statistical analysis; thomsonite; unit cell; X-ray diffraction data; zeolite group DO - http://dx.doi.org/10.1007/s00269-003-0330-6 ER - TY - JOUR T1 - Steroids in sediments from Zabuye salt lake, western Tibet; diagenetic, ecological or climatic signals? AN - 50293834; 2004-056164 AB - A 45 cm long core from Zabuye Salt Lake (Tibetan Plateau, S.W China) was studied to reveal the possible interference between diagenesis and climate signals. Steroids, including sterols and sterenes, dominate the soluble organic matter in these cores. The relative abundance of C (sub 27) sterol to the C (sub 29) sterols decreases with depth, resulting in a predominance of C (sub 29) sterols at the bottom section of this core. This change in the relative molecular distribution could be attributed to both environmental/ecological change and diagenetic complication of molecular signals. Sterols in the shallow sediments are relatively enriched in (super 13) C compared to those from lower within the core. This enrichment is possibly associated either with environmental/climatic change (e.g., increase of salinity and global pCO (sub 2) level change etc.) or it could be attributed to the biogeochemical change of organic matter during early diagenesis. 4,4-dimethyl spirosterenes and their possible precursors, 4,4-dimethyl sterenes, constitute a major component of the apolar fraction of organic matter. delta (super 13) C values of the 4,4-dimethyl sterenes indicate that they are derived from phytoplanktonic algae rather than from bacteria. The delta (super 13) C values of the regular and spiro steroids differ by >2 per mil suggesting either backbone arrangement of steroids might have involved isotopic fractionation or that these steroids are derived separately from different biological sources. JF - Organic Geochemistry AU - Wang, R L AU - Brassell, S C AU - Scarpitta, S C AU - Zheng, M P AU - Zhang, S C AU - Hayde, P R AU - Muench, L M Y1 - 2004/02// PY - 2004 DA - February 2004 SP - 157 EP - 168 PB - Pergamon, Oxford-New York VL - 35 IS - 2 SN - 0146-6380, 0146-6380 KW - Far East KW - isotopes KW - mass spectra KW - steroids KW - bonding KW - salinity KW - environmental analysis KW - stable isotopes KW - cores KW - climate change KW - carbon dioxide KW - gas chromatography KW - sampling KW - Xizang China KW - carbon KW - Tibetan Plateau KW - sediments KW - ecology KW - spectra KW - chemical composition KW - Asia KW - geochemistry KW - climate KW - China KW - salt lakes KW - isotope ratios KW - C-13/C-12 KW - sedimentation KW - molecular structure KW - organic compounds KW - Zabuye Lake KW - diagenesis KW - bacteria KW - lacustrine environment KW - microorganisms KW - lake sediments KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50293834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+Geochemistry&rft.atitle=Steroids+in+sediments+from+Zabuye+salt+lake%2C+western+Tibet%3B+diagenetic%2C+ecological+or+climatic+signals%3F&rft.au=Wang%2C+R+L%3BBrassell%2C+S+C%3BScarpitta%2C+S+C%3BZheng%2C+M+P%3BZhang%2C+S+C%3BHayde%2C+P+R%3BMuench%2C+L+M&rft.aulast=Wang&rft.aufirst=R&rft.date=2004-02-01&rft.volume=35&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Organic+Geochemistry&rft.issn=01466380&rft_id=info:doi/10.1016%2Fj.orggeochem.2003.10.003 L2 - http://www.sciencedirect.com/science/journal/01466380 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2004-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Asia; bacteria; bonding; C-13/C-12; carbon; carbon dioxide; chemical composition; China; climate; climate change; cores; diagenesis; ecology; environmental analysis; Far East; gas chromatography; geochemistry; isotope ratios; isotopes; lacustrine environment; lake sediments; mass spectra; microorganisms; molecular structure; organic compounds; salinity; salt lakes; sampling; sedimentation; sediments; spectra; stable isotopes; steroids; Tibetan Plateau; Xizang China; Zabuye Lake DO - http://dx.doi.org/10.1016/j.orggeochem.2003.10.003 ER - TY - JOUR T1 - Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells. AN - 66988419; 15494449 AB - Clustered DNA damages--two or more lesions on opposing strands and within one or two helical turns--are formed in cells by ionizing radiation or radiomimetic antitumor drugs. They are hypothesized to be difficult to repair, and thus are critical biological damages. Since individual abasic sites can be cytotoxic or mutagenic, abasic DNA clusters are likely to have significant cellular impact. Using a novel approach for distinguishing abasic clusters that are very closely spaced (putrescine cleavage) or less closely spaced (Nfo protein cleavage), we measured induction and processing of abasic clusters in 28SC human monocytes that were exposed to ionizing radiation. gamma-rays induced approximately 1 double-strand break: 1.3 putrescine-detected abasic clusters: 0.8 Nfo-detected abasic clusters. After irradiation, the 28SC cells rejoined double-strand breaks efficiently within 24 h. In contrast, in these cells, the levels of abasic clusters decreased very slowly over 14 days to background levels. In vitro repair experiments that used 28SC cell extracts further support the idea of slow processing of specific, closely spaced abasic clusters. Although some clusters were removed by active cellular repair, a substantial number was apparently decreased by 'splitting' during DNA replication and subsequent cell division. The existence of abasic clusters in 28SC monocytes, several days after irradiation suggests that they constitute persistent damages that could lead to mutation or cell killing. JF - Nucleic acids research AU - Georgakilas, Alexandros G AU - Bennett, Paula V AU - Wilson, David M AU - Sutherland, Betsy M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2004 PY - 2004 DA - 2004 SP - 5609 EP - 5620 VL - 32 IS - 18 KW - Escherichia coli Proteins KW - 0 KW - Deoxyribonuclease IV (Phage T4-Induced) KW - EC 3.1.21.2 KW - endonuclease IV, E coli KW - Putrescine KW - V10TVZ52E4 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Escherichia coli Proteins -- metabolism KW - Monocytes -- radiation effects KW - Humans KW - Monocytes -- metabolism KW - Putrescine -- metabolism KW - Cell Line KW - Deoxyribonuclease IV (Phage T4-Induced) -- metabolism KW - DNA Repair KW - Gamma Rays KW - DNA Damage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66988419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Processing+of+bistranded+abasic+DNA+clusters+in+gamma-irradiated+human+hematopoietic+cells.&rft.au=Georgakilas%2C+Alexandros+G%3BBennett%2C+Paula+V%3BWilson%2C+David+M%3BSutherland%2C+Betsy+M&rft.aulast=Georgakilas&rft.aufirst=Alexandros&rft.date=2004-01-01&rft.volume=32&rft.issue=18&rft.spage=5609&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-02 N1 - Date created - 2004-10-20 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Jun;41(6):671-6 [6288603] Mutat Res. 2003 Oct 29;531(1-2):93-107 [14637248] Photodermatol. 1985 Jun;2(3):186-91 [4022820] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):103-8 [10618378] Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):686-91 [10639140] J Biol Chem. 2000 Feb 25;275(8):5323-8 [10681505] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Annu Rev Biochem. 1999;68:255-85 [10872450] Electrophoresis. 2001 Mar;22(5):843-54 [11332751] Nucleic Acids Res. 2001 Jun 15;29(12):2558-66 [11410664] Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7426-30 [11404468] Mutat Res. 2001 May 10;485(4):283-307 [11585362] Biochemistry. 2001 Nov 6;40(44):13254-61 [11683634] Biochemistry. 2002 Jan 15;41(2):634-42 [11781104] Radiat Res. 2002 Jun;157(6):611-6 [12005538] Nucleic Acids Res. 2002 Jul 1;30(13):2800-8 [12087163] Free Radic Biol Med. 2004 Aug 15;37(4):488-99 [15256220] DNA Repair (Amst). 2004 Oct 5;3(10):1323-34 [15336627] Biochemistry. 1972 Sep 12;11(19):3618-23 [4559796] J Bacteriol. 1975 Feb;121(2):511-7 [1089633] Proc Natl Acad Sci U S A. 1976 Mar;73(3):809-12 [1062792] J Biol Chem. 1977 May 10;252(9):2808-14 [16002] Radiat Res. 1981 May;86(2):185-95 [7015409] Biochemistry. 1988 May 17;27(10):3850-7 [2457392] Biochem J. 1988 Jul 15;253(2):553-9 [2460081] Annu Rev Immunol. 1992;10:267-93 [1590988] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6601-5 [8341674] Int J Radiat Biol. 1994 Jan;65(1):7-17 [7905912] Nucleic Acids Res. 1994 Jun 11;22(11):2010-5 [7518077] J Biol Chem. 1995 Jul 7;270(27):16002-7 [7608159] J Biol Chem. 1997 Jun 20;272(25):15650-5 [9188454] EMBO J. 1997 Jun 2;16(11):3341-8 [9214649] Oncogene. 1997 Nov 20;15(21):2597-607 [9399647] Nucleic Acids Res. 1998 Jun 1;26(11):2771-8 [9592167] Cancer Res. 1999 Jan 1;59(1):14-8 [9892176] Mol Cell. 1999 Jan;3(1):33-42 [10024877] Cancer Res. 1999 Jun 1;59(11):2522-6 [10363965] J Mol Biol. 1999 Jul 16;290(3):667-84 [10395822] Nucleic Acids Res. 2002 Aug 1;30(15):3464-72 [12140332] Mutat Res. 2002 Nov 30;509(1-2):23-34 [12427529] Mol Cell Biol. 2003 Jan;23(1):382-8 [12482989] Oncogene. 2002 Dec 16;21(58):8926-34 [12483509] J Biol Chem. 2003 Mar 14;278(11):9378-81 [12519757] J Biol Chem. 2003 Mar 14;278(11):9005-12 [12519758] Nucleic Acids Res. 1982 Oct 25;10(20):6305-18 [6294597] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review. AN - 66712426; 15256343 AB - Overeating in obese individuals shares similarities with the loss of control and compulsive drug taking behavior observed in drug-addicted subjects. The mechanism of these behaviors is not well understood. Our prior studies with positron emission tomography (PET) in drug-addicted subjects documented reductions in striatal dopamine (DA) D2 receptors. In pathologically obese subjects, we found reductions in striatal DA D2 receptors similar to that in drug-addicted subjects. Moreover, DA D2 receptor levels were found to have an inverse relationship to the body mass index of the obese subjects. We postulated that decreased levels of DA D2 receptors predisposed subjects to search for reinforcers; in the case of drug-addicted subjects for the drug and in the case of the obese subjects for food as a means to temporarily compensate for a decreased sensitivity of DA D2 regulated reward circuits. Understanding the mechanism in food intake will help to suggest strategies for the treatment of obesity. JF - Journal of addictive diseases AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Thanos, Panayotis K AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, PO Box 5000, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 39 EP - 53 VL - 23 IS - 3 SN - 1055-0887, 1055-0887 KW - Receptors, Dopamine D2 KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Methamphetamine -- metabolism KW - Humans KW - Cocaine -- metabolism KW - Receptors, Dopamine D2 -- metabolism KW - Substance-Related Disorders -- diagnosis KW - Obesity -- diagnosis KW - Obesity -- metabolism KW - Positron-Emission Tomography KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66712426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Similarity+between+obesity+and+drug+addiction+as+assessed+by+neurofunctional+imaging%3A+a+concept+review.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BThanos%2C+Panayotis+K%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2004-01-01&rft.volume=23&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-19 N1 - Date created - 2004-07-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Severity of neuropsychological impairment in cocaine and alcohol addiction: association with metabolism in the prefrontal cortex. AN - 66699103; 15246283 AB - We used exploratory and confirmatory statistical approaches to study the severity of neuropsychological (NP) impairment in 42 crack/cocaine addicted subjects and in 112 comparison subjects (40 alcoholics and 72 controls). Twenty neuropsychological test indices most reliably defining predetermined cognitive domains were submitted to exploratory factor analysis. A four-dimensional model of neurocognitive function was derived: Verbal Knowledge, Visual Memory, Verbal Memory, and Attention/Executive functioning accounted for 63% of the variance. We then examined this model's association with resting glucose metabolism in the brain reward circuit measured with 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography. Results revealed that (1) cocaine addicted individuals had a generalized mild level of neurocognitive impairment (<1 S.D. below control mean); and (2) controlling for age and education, relative metabolism in the dorsolateral prefrontal cortex significantly predicted the Visual Memory and Verbal Memory factors and relative metabolism in the anterior cingulate gyrus significantly predicted the Attention/Executive factor. Nevertheless, it remains to be determined whether metabolic changes in these regions are associated with addiction. Our results also suggest that compared to cocaine, alcohol has a more detrimental effect on Attention/Executive functioning, as assessed with traditional NP measures. We conclude that relative to other psychopathological disorders (such as schizophrenia), the severity of neuropsychological impairment in cocaine addiction is modest, albeit not indicative of the absence of neurocognitive dysfunction. The impact of such small differences in performance on quality of life, and possibly on craving and relapse, may be substantial. Tasks that simulate real-life decision-making or that target specific putative cognitive-behavioral or motivational-emotional mechanisms might offer greater sensitivity in characterizing the changes that accompany addiction to drugs. Obtaining valid estimates of alcohol use in cocaine addicted subjects is essential in characterizing neurocognitive functioning in individuals addicted to drugs. JF - Neuropsychologia AU - Goldstein, Rita Z AU - Leskovjan, Andreana C AU - Hoff, Anne L AU - Hitzemann, Robert AU - Bashan, Francine AU - Khalsa, Sahib Singh AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Volkow, Nora D AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA. rgoldstein@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 1447 EP - 1458 VL - 42 IS - 11 SN - 0028-3932, 0028-3932 KW - Blood Glucose KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Index Medicus KW - Nerve Net -- diagnostic imaging KW - Blood Glucose -- metabolism KW - Gyrus Cinguli -- diagnostic imaging KW - Humans KW - Psychometrics -- statistics & numerical data KW - Models, Statistical KW - Gyrus Cinguli -- drug effects KW - Brain Mapping KW - Reward KW - Adult KW - Nerve Net -- drug effects KW - Middle Aged KW - Female KW - Male KW - Prefrontal Cortex -- diagnostic imaging KW - Neuropsychological Tests -- statistics & numerical data KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnostic imaging KW - Energy Metabolism -- drug effects KW - Tomography, Emission-Computed KW - Prefrontal Cortex -- drug effects KW - Cocaine-Related Disorders -- rehabilitation KW - Cocaine-Related Disorders -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/66699103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychologia&rft.atitle=Severity+of+neuropsychological+impairment+in+cocaine+and+alcohol+addiction%3A+association+with+metabolism+in+the+prefrontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BLeskovjan%2C+Andreana+C%3BHoff%2C+Anne+L%3BHitzemann%2C+Robert%3BBashan%2C+Francine%3BKhalsa%2C+Sahib+Singh%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2004-01-01&rft.volume=42&rft.issue=11&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Neuropsychologia&rft.issn=00283932&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-09-17 N1 - Date created - 2004-07-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Deployment of a colloidal silica barrier at Brookhaven National Laboratory AN - 51781248; 2004-072457 AB - A colloidal silica (CS) barrier was deployed at Brookhaven National Laboratory (BNL) on Long Island, New York. Contamination including tritium ( (super 3) H) and sodium-22 ( (super 22) Na) was detected downgradient of the Brookhaven Linear Accelerator Isotope Producer (BLIP) during routine groundwater monitoring. An investigation was performed to confirm the BLIP was the source of the groundwater contamination and to determine the extent of the contamination. (CDM 1999) BNL then completed an Engineering Evaluation and Cost Analysis for the remediation/containment of the contaminated soils. The analysis recommended the emplacement of a CS barrier to encapsulate the contaminated soils beneath the BLIP building to prevent further migration of the contaminants to the groundwater. The CS barrier was emplaced in 2000 via downstage permeation grouting. The grout was injected from approximately 6 meters below ground surface (bgs) down to 10 meters bgs, encapsulating approximately 73 cubic meters of contaminated soil. In situ permeameter testing was conducted on a test panel adjacent to the barrier, so the integrity of the barrier would not be compromised. Using the measurements from the field permeameter testing and correlations previously developed from modeling and laboratory sand tank testing, it was determined that the flux through the test panel (and thus the barrier) met the BNL requirement. JF - Proceedings of the Symposium on Engineering Geology and Geotechnical Engineering AU - North-Abbott, Mary A AU - Manchester, Kenneth R AU - Trudnowski, John AU - Moe, Martin AU - Bickford, Jody AU - Zaluski, Marek H AU - Heiser, John H A2 - MacLaughlin, Mary M. A2 - McNearny, Richard L. Y1 - 2004 PY - 2004 DA - 2004 SP - 65 EP - 68 PB - [publisher varies], [location varies] VL - 39 KW - United States KW - colloidal materials KW - monitoring KW - isotopes KW - Brookhaven National Laboratory KW - alkali metals KW - waste disposal sites KW - pollution KW - tritium KW - sodium KW - ground water KW - Suffolk County New York KW - New York KW - radioactive isotopes KW - metals KW - infiltration KW - hydrogen KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51781248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Symposium+on+Engineering+Geology+and+Geotechnical+Engineering&rft.atitle=Deployment+of+a+colloidal+silica+barrier+at+Brookhaven+National+Laboratory&rft.au=North-Abbott%2C+Mary+A%3BManchester%2C+Kenneth+R%3BTrudnowski%2C+John%3BMoe%2C+Martin%3BBickford%2C+Jody%3BZaluski%2C+Marek+H%3BHeiser%2C+John+H&rft.aulast=North-Abbott&rft.aufirst=Mary&rft.date=2004-01-01&rft.volume=39&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Symposium+on+Engineering+Geology+and+Geotechnical+Engineering&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 39th symposium on Engineering geology and geotechnical engineering N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 3 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - CODEN - #02957 N1 - SubjectsTermNotLitGenreText - alkali metals; Brookhaven National Laboratory; colloidal materials; ground water; hydrogen; infiltration; isotopes; metals; monitoring; New York; pollution; radioactive isotopes; sodium; Suffolk County New York; tritium; United States; waste disposal sites ER - TY - JOUR T1 - Synchrotron X-ray diffraction analysis of meteorites in thin section; preliminary results AN - 50540351; 2009-009387 JF - Abstracts of Papers Submitted to the Lunar and Planetary Science Conference AU - Treiman, A H AU - Lanzirotti, A AU - Xirouchakis, D AU - Anonymous Y1 - 2004 PY - 2004 DA - 2004 EP - unpaginated PB - Lunar and Planetary Science Conference, Houston, TX VL - 35 KW - silicates KW - Yamato Meteorites KW - chemical analysis KW - stony meteorites KW - iddingsite KW - X-ray diffraction data KW - Lafayette Meteorite KW - smectite KW - thin sections KW - synchrotron X-ray diffraction analysis KW - achondrites KW - clay minerals KW - meteorites KW - Serra de Mage Meteorite KW - Y 000749 KW - mineral composition KW - silica KW - eucrite KW - synchrotrons KW - sheet silicates KW - 05B:Petrology of meteorites and tektites KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50540351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.atitle=Synchrotron+X-ray+diffraction+analysis+of+meteorites+in+thin+section%3B+preliminary+results&rft.au=Treiman%2C+A+H%3BLanzirotti%2C+A%3BXirouchakis%2C+D%3BAnonymous&rft.aulast=Treiman&rft.aufirst=A&rft.date=2004-01-01&rft.volume=35&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+Papers+Submitted+to+the+Lunar+and+Planetary+Science+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.lpi.usra.edu/meetings/lpsc2004/pdf/1172.pdf LA - English DB - GeoRef N1 - Conference title - Thirty-fifth lunar and planetary science conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - Number of references - 17 N1 - PubXState - TX N1 - Document feature - illus. N1 - SuppNotes - Accessed on June 22, 2007 N1 - Last updated - 2012-06-07 N1 - CODEN - #02179 N1 - SubjectsTermNotLitGenreText - achondrites; chemical analysis; clay minerals; eucrite; iddingsite; Lafayette Meteorite; meteorites; mineral composition; Serra de Mage Meteorite; sheet silicates; silica; silicates; smectite; stony meteorites; synchrotron X-ray diffraction analysis; synchrotrons; thin sections; X-ray diffraction data; Y 000749; Yamato Meteorites ER - TY - JOUR T1 - Solid-phase As speciation in roaster-derived Au mine tailings AN - 50119094; 2010-003015 JF - Proceedings - International Symposium on Water-Rock Interaction AU - Walker, S R AU - Jamieson, H E AU - Andrade, C F AU - Lanzirotti, A A2 - Wanty, Richard B. A2 - Seal, Robert R., II Y1 - 2004 PY - 2004 DA - 2004 SP - 641 EP - 645 PB - Taylor & Francis VL - 11 SN - 0258-7610, 0258-7610 KW - mining KW - X-ray diffraction data KW - techniques KW - environmental analysis KW - electron probe data KW - XANES spectra KW - Yellowknife Northwest Territories KW - water-rock interaction KW - sediments KW - oxides KW - gold ores KW - spectra KW - geochemistry KW - smelting KW - soils KW - mines KW - waste rock KW - pollutants KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - solid phase KW - Canada KW - dissolved materials KW - metals KW - metal ores KW - Western Canada KW - waste disposal KW - tailings KW - sulfides KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments KW - 27A:Economic geology, geology of ore deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50119094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.atitle=Solid-phase+As+speciation+in+roaster-derived+Au+mine+tailings&rft.au=Walker%2C+S+R%3BJamieson%2C+H+E%3BAndrade%2C+C+F%3BLanzirotti%2C+A&rft.aulast=Walker&rft.aufirst=S&rft.date=2004-01-01&rft.volume=11&rft.issue=&rft.spage=641&rft.isbn=9058096416&rft.btitle=&rft.title=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.issn=02587610&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international symposium on Water-rock interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 5 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; chemical fractionation; dissolved materials; electron probe data; environmental analysis; geochemistry; gold ores; metal ores; metals; mines; mining; Northwest Territories; oxides; pollutants; pollution; sediments; smelting; soils; solid phase; spectra; sulfides; tailings; techniques; waste disposal; waste rock; water-rock interaction; Western Canada; X-ray diffraction data; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Remobilization of precipitated and cell-associated uranium in brines AN - 50118256; 2010-003022 JF - Proceedings - International Symposium on Water-Rock Interaction AU - Dodge, C J AU - Gillow, J B AU - Francis, A J A2 - Wanty, Richard B. A2 - Seal, Robert R., II Y1 - 2004 PY - 2004 DA - 2004 SP - 679 EP - 682 PB - Taylor & Francis VL - 11 SN - 0258-7610, 0258-7610 KW - United States KW - Eddy County New Mexico KW - New Mexico KW - environmental analysis KW - ground water KW - carbon dioxide KW - absorption KW - chemical reactions KW - water-rock interaction KW - transport KW - Waste Isolation Pilot Plant KW - chemical composition KW - geochemistry KW - experimental studies KW - assemblages KW - pollution KW - migration of elements KW - hydrochemistry KW - biogenic processes KW - X-ray data KW - precipitation KW - metals KW - brines KW - bacteria KW - EXAFS data KW - dissolution KW - uranium KW - mobilization KW - transformations KW - actinides KW - microorganisms KW - 02B:Hydrochemistry KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50118256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.atitle=Remobilization+of+precipitated+and+cell-associated+uranium+in+brines&rft.au=Dodge%2C+C+J%3BGillow%2C+J+B%3BFrancis%2C+A+J&rft.aulast=Dodge&rft.aufirst=C&rft.date=2004-01-01&rft.volume=11&rft.issue=&rft.spage=679&rft.isbn=9058096416&rft.btitle=&rft.title=Proceedings+-+International+Symposium+on+Water-Rock+Interaction&rft.issn=02587610&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Eleventh international symposium on Water-rock interaction N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 10 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absorption; actinides; assemblages; bacteria; biogenic processes; brines; carbon dioxide; chemical composition; chemical reactions; dissolution; Eddy County New Mexico; environmental analysis; EXAFS data; experimental studies; geochemistry; ground water; hydrochemistry; metals; microorganisms; migration of elements; mobilization; New Mexico; pollution; precipitation; transformations; transport; United States; uranium; Waste Isolation Pilot Plant; water-rock interaction; X-ray data ER - TY - JOUR T1 - Upstream plasticity and downstream robustness in evolution of molecular networks AN - 19815788; 6044832 AB - Gene duplication followed by the functional divergence of the resulting pair of paralogous proteins is a major force shaping molecular networks in living organisms. Recent species-wide data for protein-protein interactions and transcriptional regulations allow us to assess the effect of gene duplication on robustness and plasticity of these molecular networks. We demonstrate that the transcriptional regulation of duplicated genes in baker's yeast Saccharomyces cerevisiae diverges fast so that on average they lose 3% of common transcription factors for every 1% divergence of their amino acid sequences. The set of protein-protein interaction partners of their protein products changes at a slower rate exhibiting a broad plateau for amino acid sequence similarity above 70%. The stability of functional roles of duplicated genes at such relatively low sequence similarity is further corroborated by their ability to substitute for each other in single gene knockout experiments in yeast and RNAi experiments in a nematode worm Caenorhabditis elegans. We also quantified the divergence rate of physical interaction neighborhoods of paralogous proteins in a bacterium Helicobacter pylori and a fly Drosophila melanogaster. However, in the absence of system-wide data on transcription factors' binding in these organisms we could not compare this rate to that of transcriptional regulation of duplicated genes. For all molecular networks studied in this work we found that even the most distantly related paralogous proteins with amino acid sequence identities around 20% on average have more similar positions within a network than a randomly selected pair of proteins. For yeast we also found that the upstream regulation of genes evolves more rapidly than downstream functions of their protein products. This is in accordance with a view which puts regulatory changes as one of the main driving forces of the evolution. In this context a very important open question is to what extent our results obtained for homologous genes within a single species (paralogs) carries over to homologous proteins in different species (orthologs). JF - BMC Evolutionary Biology AU - Maslov, Sergei AU - Sneppen, Kim AU - Eriksen, Kasper Astrup AU - Yan, Koon-Kiu AD - Department of Physics, Brookhaven National Laboratory, Upton, New York 11973, USA, maslov@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 4 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Helicobacter pylori KW - Data processing KW - Transcription KW - Saccharomyces cerevisiae KW - gene duplication KW - Gene regulation KW - Transcription factors KW - Caenorhabditis elegans KW - Drosophila melanogaster KW - RNA-mediated interference KW - Nematoda KW - Evolution KW - Protein interaction KW - Amino acid sequence KW - J 02410:Animal Diseases KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19815788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Evolutionary+Biology&rft.atitle=Upstream+plasticity+and+downstream+robustness+in+evolution+of+molecular+networks&rft.au=Maslov%2C+Sergei%3BSneppen%2C+Kim%3BEriksen%2C+Kasper+Astrup%3BYan%2C+Koon-Kiu&rft.aulast=Maslov&rft.aufirst=Sergei&rft.date=2004-01-01&rft.volume=4&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Evolutionary+Biology&rft.issn=1471-2148&rft_id=info:doi/10.1186%2F1471-2148-4-9 L2 - http://www.biomedcentral.com/content/pdf/1471-2148-4-9.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Transcription factors; Gene regulation; RNA-mediated interference; Transcription; Protein interaction; Evolution; Amino acid sequence; gene duplication; Helicobacter pylori; Drosophila melanogaster; Caenorhabditis elegans; Nematoda; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1186/1471-2148-4-9 ER - TY - JOUR T1 - How Much Is Enough: Real-Time Detection and Identification of Biological Weapon Agents AN - 18035511; 5997621 AB - Winning the war against terrorism will require adoption of new strategies for decision-making, communication, and research and development. This is particularly true with respect to real-time detection and identification (DI) of Biological Weapons (BW). Real-time bio-sensors presently used by the military do not satisfy the requirements for a civilian environment. More sophisticated BW sensors are needed with false positives and false negatives minimized and addressed. Expert first responders and health professionals in a few cities are becoming familiar with Polymerase Chain Reaction (PCR)-based sensors, but are mostly unaware of other real-time BW DI possibilities in the R&D pipeline. The aim of this paper is to provide individuals outside of the BW research community with an overview of the current status and future prospects for real-time BW detection and identification. It is expected that the Dept. of Homeland Security will play an essential role in establishing incentive systems so that the most appropriate research is conducted and evaluated with peer review using both scientists and first responders. This type of overall strategy has the potential to finally produce real-time biosensors with required properties and keep our BW preparedness ahead of our terrorist enemies' emerging capabilities. JF - Journal of Homeland Security and Emergency Management AU - Graham, T W AU - Sabelnikov, A G AD - Brookhaven National Laboratory Y1 - 2004 PY - 2004 DA - 2004 VL - 1 IS - 3 SN - 1547-7355, 1547-7355 KW - Health & Safety Science Abstracts; Risk Abstracts KW - bioterrorism KW - decision making KW - Biosensors KW - Communications KW - Emergency preparedness KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18035511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Homeland+Security+and+Emergency+Management&rft.atitle=How+Much+Is+Enough%3A+Real-Time+Detection+and+Identification+of+Biological+Weapon+Agents&rft.au=Graham%2C+T+W%3BSabelnikov%2C+A+G&rft.aulast=Graham&rft.aufirst=T&rft.date=2004-01-01&rft.volume=1&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Homeland+Security+and+Emergency+Management&rft.issn=15477355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Emergency preparedness; Biosensors; decision making; Communications; bioterrorism ER - TY - JOUR T1 - Chlorophyll Chemistry Before and After Crystals of Photosynthetic Reaction Centers AN - 17823788; 6023485 AB - The experimental, theoretical and structural research leading to the identification and characterization of the (bacterio) chlorophyll species that mediate the primary events of solar energy transduction and dynamics is reviewed and examined from the author's perspective. JF - Photosynthesis Research AU - Fajer, J AD - Materials Science Department, Brookhaven National Laboratory, Building 555, Upton, NY 11973-5000, USA, fajerj@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 165 EP - 172 PB - Kluwer Academic Publishers VL - 80 IS - 1-3 SN - 0166-8595, 0166-8595 KW - Microbiology Abstracts B: Bacteriology KW - Chlorophyll KW - Photosynthesis KW - Reviews KW - Energy transduction KW - Crystals KW - Reaction centers KW - J 02723:Photosynthesis, electron transport and related phenomena UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17823788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photosynthesis+Research&rft.atitle=Chlorophyll+Chemistry+Before+and+After+Crystals+of+Photosynthetic+Reaction+Centers&rft.au=Fajer%2C+J&rft.aulast=Fajer&rft.aufirst=J&rft.date=2004-01-01&rft.volume=80&rft.issue=1-3&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Photosynthesis+Research&rft.issn=01668595&rft_id=info:doi/10.1023%2FB%3APRES.0000030422.69367.db LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chlorophyll; Reaction centers; Reviews; Crystals; Energy transduction; Photosynthesis DO - http://dx.doi.org/10.1023/B:PRES.0000030422.69367.db ER - TY - JOUR T1 - Molecular orientation of ultrahigh molecular weight polyethylene induced by various sliding motions AN - 17588753; 6026156 AB - Wear and wear debris of ultrahigh molecular weight polyethylene (UHMWPE) in joint replacements have been recognized as one of the major contributors to the failure of orthopedic implants. The detailed wear mechanism of polyethylene under biomechanic motions is not well understood. In simulation wear bench tests, it was found that unidirectional sliding produces the least amount of wear, reciprocating motion increases wear significantly, and cross-shear motion (similar to hip and knee joint motion in the human body) produces the highest amount of wear. Conventional wear theories are inadequate to explain this observation. This study utilizes resonant absorption of linearly polarized soft X-rays at a synchrotron radiation beam line to measure the molecular orientation of a UHMWPE surface layer subjected to different wear motions. Carbon-K-edge partial-electron-yield X-ray absorption measurements were done on the worn UHMWPE samples. X-ray absorption measurements show conclusively that the molecular chains of UHMWPE align preferentially parallel to the direction of sliding. Examination under various wear motions showed that unidirectional shear produced the maximum chain orientation, whereas cross-shear wear motions produced the least amount of orientation. When polymeric chains align, the surface layer tends to be more brittle and hard, thus resisting wear. When they do not align, loose chains may be subjected to both Mode I and Mode II fracture, hence increasing the wear rate. This molecular alignment observation may offer an explanation of why different wear motions have different wear characteristics. JF - Journal of Biomedical Materials Research, Part B: Applied Biomaterials AU - Sambasivan, Sharadha AU - Fischer, Daniel A AU - Shen, Ming C AU - Hsu, Stephen M AD - Ceramics Division, MSEL, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, sharadha@bnl.gov Y1 - 2004 PY - 2004 DA - 2004 SP - 278 EP - 285 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 70B IS - 2 SN - 0021-9304, 0021-9304 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - ^a Radiation KW - Molecular weight KW - Polyethylene KW - Orthopedics KW - Particulate matter KW - Fractures KW - Biomaterials KW - Knee KW - Biomechanics KW - Joints KW - Hip KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17588753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.atitle=Molecular+orientation+of+ultrahigh+molecular+weight+polyethylene+induced+by+various+sliding+motions&rft.au=Sambasivan%2C+Sharadha%3BFischer%2C+Daniel+A%3BShen%2C+Ming+C%3BHsu%2C+Stephen+M&rft.aulast=Sambasivan&rft.aufirst=Sharadha&rft.date=2004-01-01&rft.volume=70B&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Materials+Research%2C+Part+B%3A+Applied+Biomaterials&rft.issn=00219304&rft_id=info:doi/10.1002%2Fjbm.b.30043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Polyethylene; Hip; Molecular weight; ^a Radiation; Joints; Biomechanics; Biomaterials; Particulate matter; Orthopedics; Knee; Fractures DO - http://dx.doi.org/10.1002/jbm.b.30043 ER - TY - JOUR T1 - Expectation enhances the regional brain metabolic and the reinforcing effects of stimulants in cocaine abusers. AN - 71471524; 14673011 AB - The reinforcing effects of drugs of abuse result from the complex interaction between pharmacological effects and conditioned responses. Here we evaluate how expectation affects the response to the stimulant drug methylphenidate in 25 cocaine abusers. The effects of methylphenidate (0.5 mg/kg, i.v.) on brain glucose metabolism (measured by [18F]deoxyglucose-positron emission tomography) and on its reinforcing effects (self-reports of drug effects) were evaluated in four conditions: (1) expecting placebo and receiving placebo; (2) expecting placebo and receiving methylphenidate; (3) expecting methylphenidate and receiving methylphenidate; (4) expecting methylphenidate and receiving placebo. Methylphenidate increased brain glucose metabolism, and the largest changes were in cerebellum, occipital cortex, and thalamus. The increases in metabolism were approximately 50% larger when methylphenidate was expected than when it was not, and these differences were significant in cerebellum (vermis) and thalamus. In contrast, unexpected methylphenidate induced greater increases in left lateral orbitofrontal cortex than when it was expected. Methylphenidate-induced increases in self-reports of "high" were also approximately 50% greater when subjects expected to receive it than when they did not and were significantly correlated with the metabolic increases in thalamus but not in cerebellum. These findings provide evidence that expectation amplifies the effects of methylphenidate in brain and its reinforcing effects. They also suggest that the thalamus, a region involved with conditioned responses, may mediate the enhancement of the reinforcing effects of methylphenidate by expectation and that the orbitofrontal cortex mediates the response to unexpected reinforcement. The enhanced cerebellar activation with expectation may reflect conditioned responses that are not linked to conscious responses. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Ma, Yemin AU - Fowler, Joanna S AU - Zhu, Wei AU - Maynard, Laurence AU - Telang, Frank AU - Vaska, Paul AU - Ding, Yu-Shin AU - Wong, Christopher AU - Swanson, James M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. nvolkow@nida.nih.gov Y1 - 2003/12/10/ PY - 2003 DA - 2003 Dec 10 SP - 11461 EP - 11468 VL - 23 IS - 36 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Humans KW - Glucose -- metabolism KW - Adult KW - Tomography, Emission-Computed KW - Male KW - Female KW - Central Nervous System Stimulants -- pharmacology KW - Conditioning (Psychology) KW - Methylphenidate -- pharmacology KW - Brain -- drug effects KW - Reinforcement (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Brain -- metabolism KW - Cocaine-Related Disorders -- metabolism KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71471524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Expectation+enhances+the+regional+brain+metabolic+and+the+reinforcing+effects+of+stimulants+in+cocaine+abusers.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMa%2C+Yemin%3BFowler%2C+Joanna+S%3BZhu%2C+Wei%3BMaynard%2C+Laurence%3BTelang%2C+Frank%3BVaska%2C+Paul%3BDing%2C+Yu-Shin%3BWong%2C+Christopher%3BSwanson%2C+James+M&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-12-10&rft.volume=23&rft.issue=36&rft.spage=11461&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-16 N1 - Date created - 2003-12-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Positron emission tomography studies of potential mechanisms underlying phencyclidine-induced alterations in striatal dopamine. AN - 71413718; 12888780 AB - Positron emission tomography (PET), in combination with (11)C-raclopride, was used to examine the effects of phencyclidine (PCP) on dopamine (DA) in the primate striatum. In addition, we explored the hypotheses that GABAergic pathways as well as molecular targets beyond the N-methyl-D-aspartate (NMDA) receptor complex (ie dopamine transporter proteins, DAT) contribute to PCP's effects. In the first series of experiments, (11)C-raclopride was administered at baseline and 30 min following intravenous PCP administration. In the second series of studies, gamma-vinyl GABA (GVG) was used to assess whether enhanced GABAergic tone altered NMDA antagonist-induced changes in DA. Animals received an initial PET scan followed by pretreatment with GVG (300 mg/kg), then PCP 30 min prior to a second scan. Finally, we explored the possible contributions of DAT blockade to PCP-induced increases in DA. By examining (11)C-cocaine binding a paradigm in which PCP was coadministered with the radiotracer, we assessed the direct competition between these two compounds for the DAT. At 0.1, 0.5, and 1.0 mg/kg, PCP decreased (11)C-raclopride binding by 2.1, 14.9+/-2.2 and 8.18+/-1.1%, respectively. These effects were completely attenuated by GVG (3.38+/-3.1% decrease in (11)C-raclopride binding). Finally, PCP (0.5 mg/kg) decreased (11)C-cocaine binding by 25.5+/-4.3%, while at 1.0 mg/kg this decrease was 13.5%, consistent with a competitive interaction at the DAT. These results suggest that PCP may be exerting some direct effects through the DAT and that GABA partially modulates NMDA-antagonist-induced increases in striatal DA. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Schiffer, Wynne K AU - Logan, Jean AU - Dewey, Stephen L AD - SUNY Stony Brook, Department of Neurobiology and Behavior, Stony Brook, NY 11973, USA. wynne@bnl.gov Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 2192 EP - 2198 VL - 28 IS - 12 SN - 0893-133X, 0893-133X KW - Anticonvulsants KW - 0 KW - Antipsychotic Agents KW - Carbon Isotopes KW - Excitatory Amino Acid Antagonists KW - Raclopride KW - 430K3SOZ7G KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Phencyclidine KW - J1DOI7UV76 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Papio KW - Animals KW - Cerebellum -- diagnostic imaging KW - Vigabatrin -- pharmacology KW - Analysis of Variance KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Cerebellum -- metabolism KW - Anticonvulsants -- pharmacology KW - Antipsychotic Agents -- pharmacokinetics KW - Cerebellum -- drug effects KW - Carbon Isotopes -- pharmacokinetics KW - Cocaine -- pharmacokinetics KW - Time Factors KW - Raclopride -- pharmacokinetics KW - Female KW - Corpus Striatum -- diagnostic imaging KW - Corpus Striatum -- metabolism KW - Phencyclidine -- pharmacology KW - Tomography, Emission-Computed KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71413718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Positron+emission+tomography+studies+of+potential+mechanisms+underlying+phencyclidine-induced+alterations+in+striatal+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BLogan%2C+Jean%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-12-01&rft.volume=28&rft.issue=12&rft.spage=2192&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-10 N1 - Date created - 2003-11-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Dr. Mow Lin (1941-2003) AN - 51532152; 2006-086340 JF - Bulletin - Geothermal Resources Council AU - Seubert, Liz AU - Berndt, Marita Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 245 PB - Geothermal Resources Council, Davis, CA VL - 32 IS - 6 SN - 0160-7782, 0160-7782 KW - energy sources KW - Lin, Mow KW - biography KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51532152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+-+Geothermal+Resources+Council&rft.atitle=Dr.+Mow+Lin+%281941-2003%29&rft.au=Seubert%2C+Liz%3BBerndt%2C+Marita&rft.aulast=Seubert&rft.aufirst=Liz&rft.date=2003-12-01&rft.volume=32&rft.issue=6&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Bulletin+-+Geothermal+Resources+Council&rft.issn=01607782&rft_id=info:doi/ L2 - http://geothermal.org/bulletin.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2013-06-13 N1 - CODEN - BGRCDD N1 - SubjectsTermNotLitGenreText - biography; energy sources; Lin, Mow ER - TY - JOUR T1 - In situ high pressure angle dispersive X-ray diffraction experiments; with sagittally-bent double Laue monochomator AN - 51380764; 2007-105517 JF - Eos, Transactions, American Geophysical Union AU - Hu, Jingzhu AU - Zhong, Zhong AU - Liu, Hauzhe AU - Guo, Quanzhong AU - Mao, Ho-kwang AU - Hemley, Russell J AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - F1590 EP - F1591 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - physical properties KW - experimental studies KW - pressure KW - in situ KW - X-ray diffraction data KW - techniques KW - anvil cells KW - high pressure KW - minerals KW - instruments KW - measurement KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51380764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=In+situ+high+pressure+angle+dispersive+X-ray+diffraction+experiments%3B+with+sagittally-bent+double+Laue+monochomator&rft.au=Hu%2C+Jingzhu%3BZhong%2C+Zhong%3BLiu%2C+Hauzhe%3BGuo%2C+Quanzhong%3BMao%2C+Ho-kwang%3BHemley%2C+Russell+J%3BAnonymous&rft.aulast=Hu&rft.aufirst=Jingzhu&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=F1590&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - anvil cells; experimental studies; high pressure; in situ; instruments; measurement; minerals; physical properties; pressure; techniques; X-ray diffraction data ER - TY - JOUR T1 - Biotransformation of Pu(VI) by microorganisms AN - 51010454; 2008-093545 JF - Eos, Transactions, American Geophysical Union AU - Ohnuki, Toshihiko AU - Yoshida, Takahiro AU - Ozaki, Takuo AU - Francis, Arokiasamy J AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - 1 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - silicates KW - high-level waste KW - sorption KW - experimental studies KW - Bacillus subtilis KW - plutonium KW - oxidation KW - kaolinite KW - bioremediation KW - remediation KW - radioactive waste KW - clay minerals KW - biogenic processes KW - transport KW - metals KW - bacteria KW - sheet silicates KW - waste disposal KW - transformations KW - Bacillus KW - actinides KW - pH KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51010454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Biotransformation+of+Pu%28VI%29+by+microorganisms&rft.au=Ohnuki%2C+Toshihiko%3BYoshida%2C+Takahiro%3BOzaki%2C+Takuo%3BFrancis%2C+Arokiasamy+J%3BAnonymous&rft.aulast=Ohnuki&rft.aufirst=Toshihiko&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=F308&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - actinides; Bacillus; Bacillus subtilis; bacteria; biogenic processes; bioremediation; clay minerals; experimental studies; high-level waste; kaolinite; metals; microorganisms; oxidation; pH; plutonium; radioactive waste; remediation; sheet silicates; silicates; sorption; transformations; transport; waste disposal ER - TY - JOUR T1 - Organic sulfur associated with aquatic humic substances AN - 50419749; 2009-054913 JF - Eos, Transactions, American Geophysical Union AU - Aiken, George AU - Vairavamurthy, Murthy A AU - Ravichandran, Mahalingham AU - Anonymous Y1 - 2003/12// PY - 2003 DA - December 2003 SP - Abstract B52F EP - 06 PB - American Geophysical Union, Washington, DC VL - 84 IS - 46, Suppl. SN - 0096-3941, 0096-3941 KW - United States KW - thiophenes KW - Everglades KW - oxidation KW - Florida KW - X-ray spectra KW - XANES spectra KW - reactivity KW - organic compounds KW - humic substances KW - quantitative analysis KW - dissolved materials KW - metals KW - Pacific Ocean KW - thiols KW - sulfur KW - spectra KW - aquatic environment KW - organic sulfur KW - Eh KW - mercury KW - chemical fractionation KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50419749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Organic+sulfur+associated+with+aquatic+humic+substances&rft.au=Aiken%2C+George%3BVairavamurthy%2C+Murthy+A%3BRavichandran%2C+Mahalingham%3BAnonymous&rft.aulast=Aiken&rft.aufirst=George&rft.date=2003-12-01&rft.volume=84&rft.issue=46%2C+Suppl.&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2003 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2009-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - aquatic environment; chemical fractionation; dissolved materials; Eh; Everglades; Florida; humic substances; mercury; metals; organic compounds; organic sulfur; oxidation; Pacific Ocean; quantitative analysis; reactivity; spectra; sulfur; thiols; thiophenes; United States; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Airborne measurement of inorganic ionic components of fine aerosol particles using the particle-into-liquid sampler coupled to ion chromatography technique during ACE-Asia and TRACE-P AN - 1654672792; 21161019 AB - Eight inorganic ions in fine aerosol particles (D sub(p) 1 ppbv only in the top 1% sample population. During TRACE-P, NH sub(4) super(+) dominated, followed by SO sub(4) super(2-), Cl super(-), Na super(+), NO sub(3) super(-), Ca super(2+), and K super(+), in decreasing order of importance. In addition to a sea-salt origin, Cl super(-) showed a source in urban emissions possibly related to biofuel combustion. Both sea salt and dust contributed to Mg super(2+). In both experiments, NH sub(4) super(+), SO sub(4) super(2-), NO sub(3) super(-), and CO were strongly correlated, indicating that combustion was the dominant source of these species and that NH sub(3) and other alkaline materials were in sufficient supply to neutralize H sub(2)SO sub(4). The [NH sub(4) super(+)] to ([NO sub(3) super(-)] + 2[SO sub(4) super(2-)]) ratio was 0.70 in the two campaigns, with deviations found only in volcano plumes, whereby SO sub(4) super(2-) was found to correlate with SO sub(2). Charge balance of the ions showed both positive and negative deviations whose magnitudes, 30%, provide estimates of the lower limits of unmeasured ions. Elevated NO sub(3) super(-) and Ca super(2+) coexist mainly under polluted conditions, suggesting the importance of sequestering HNO sub(3) by mineral dust. JF - Journal of Geophysical Research: Atmospheres AU - Lee, Y-N AU - Weber, R AU - Ma, Y AU - Orsini, D AU - Maxwell-Meier, K AU - Blake, D AU - Meinardi, S AU - Sachse, G AU - Harward, C AU - Chen, T-Y AU - Thornton, D AU - Tu, F-H AU - Bandy, A AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA. Y1 - 2003/12// PY - 2003 DA - Dec 2003 SP - [np] VL - 108 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts KW - Fuel technology KW - Ions KW - Aerosols KW - Chromatography KW - Volcanoes KW - Particulates KW - Dust KW - Combustion KW - Salts KW - Sulfur dioxide KW - Aircraft KW - Emissions KW - Plumes KW - Biofuels KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654672792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research%3A+Atmospheres&rft.atitle=Airborne+measurement+of+inorganic+ionic+components+of+fine+aerosol+particles+using+the+particle-into-liquid+sampler+coupled+to+ion+chromatography+technique+during+ACE-Asia+and+TRACE-P&rft.au=Lee%2C+Y-N%3BWeber%2C+R%3BMa%2C+Y%3BOrsini%2C+D%3BMaxwell-Meier%2C+K%3BBlake%2C+D%3BMeinardi%2C+S%3BSachse%2C+G%3BHarward%2C+C%3BChen%2C+T-Y%3BThornton%2C+D%3BTu%2C+F-H%3BBandy%2C+A&rft.aulast=Lee&rft.aufirst=Y-N&rft.date=2003-12-01&rft.volume=108&rft.issue=D23&rft.spage=%5Bnp%5D&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research%3A+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2002JD003265 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-02-12 N1 - SubjectsTermNotLitGenreText - Ions; Fuel technology; Aerosols; Chromatography; Volcanoes; Particulates; Dust; Combustion; Salts; Sulfur dioxide; Aircraft; Emissions; Plumes; Biofuels DO - http://dx.doi.org/10.1029/2002JD003265 ER - TY - JOUR T1 - A comparative study of O sub(3) formation in the Houston urban and industrial plumes during the 2000 Texas Air Quality Study AN - 16163880; 5821841 AB - Ozone formation in the Houston area during a period of high ozone concentrations that occurred on 29 August 2000 during the TexAQS 2000 study is examined to understand differences in the sources of O sub(3) precursors and the rate and efficiency of ozone formation over the city of Houston and the industrialized Ship Channel region to the east of Houston. From late morning through late afternoon on 29 August, a period of stagnation occurred, allowing accumulation of O sub(3) and product species separately over downtown Houston and the Houston Ship Channel. Three aircraft flights were made in the region, starting from about 0900 CST and extending to about 1700 CST. A localized plume of high O sub(3) ranging between 120 and 200 ppb was observed over the Ship Channel on all of these aircraft flights. Over the same time period, O sub(3) concentrations over the city were much lower ranging between 40 and 90 ppb. NO sub(x) concentrations measured in the two regions in the late morning were roughly the same, but hydrocarbon reactivities over the industrial area were much higher, by as much as a factor of 10. Photochemical box model calculations constrained by observations of NO sub(x), hydrocarbons, O sub(3), and other stable species indicated that the instantaneous ozone formation rate was much lower (3- 18 ppb/h) over downtown Houston than it was over the Ship Channel (3-80 ppb/h). The much faster O sub(3) formation rates and higher concentrations observed over the Ship Channel are attributed to the much higher hydrocarbon reactivity, the majority of which was contributed by low molecular weight alkenes. These high hydrocarbon reactivities also caused O sub(3) over the Ship Channel to be produced with much higher efficiency than over urban Houston. Comparison of photochemical product distributions suggests that O sub(3) formation in the urban area is much more hydrocarbon limited than in the Ship Channel, consistent with the geographic distribution of major hydrocarbon sources in the area. JF - Journal of Geophysical Research. D. Atmospheres AU - Daum, PH AU - Kleinman, LI AU - Springston AU - Nunnermacker, L J AU - Lee, Y-N AU - Weinstein-Lloyd, J AU - Zheng, J AU - Berkowitz, C M AD - Environmental Sciences Department, Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2003/12// PY - 2003 DA - Dec 2003 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 108 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - Citation No. 4715 KW - urban pollution KW - ozone formation KW - industrial hydrocarbons KW - 0345 Atmospheric Composition and Structure: Pollution KW - urban and regional (0305) KW - 0365 Atmospheric Composition and Structure: Troposphere KW - composition and chemistry KW - 0368 Atmospheric Composition and Structure: Troposphere KW - constituent transport and chemistry KW - Ships KW - Air quality measurements KW - Photochemical ozone production KW - Hydrocarbons KW - Nitrogen oxides KW - Atmosphere KW - Ozone formation KW - Air quality models KW - Airplane observation of ozone KW - Industrial areas KW - Plumes KW - USA, Texas, Houston KW - Marine transportation KW - Industrial atmospheric pollution KW - Ozone KW - Urban areas KW - Plume dispersion KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - M2 551.556.42:Short-range: plumes (551.556.42) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16163880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=A+comparative+study+of+O+sub%283%29+formation+in+the+Houston+urban+and+industrial+plumes+during+the+2000+Texas+Air+Quality+Study&rft.au=Daum%2C+PH%3BKleinman%2C+LI%3BSpringston%3BNunnermacker%2C+L+J%3BLee%2C+Y-N%3BWeinstein-Lloyd%2C+J%3BZheng%2C+J%3BBerkowitz%2C+C+M&rft.aulast=Daum&rft.aufirst=PH&rft.date=2003-12-01&rft.volume=108&rft.issue=D23&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2003JD003552 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-06-01 N1 - SuppNotes - Publication date refers to online version. N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Photochemical ozone production; Airplane observation of ozone; Industrial atmospheric pollution; Ozone formation; Air quality models; Plume dispersion; Ships; Air quality measurements; Hydrocarbons; Industrial areas; Nitrogen oxides; Atmosphere; Plumes; Marine transportation; Urban areas; Ozone; USA, Texas, Houston DO - http://dx.doi.org/10.1029/2003JD003552 ER - TY - JOUR T1 - The structure of the S127P mutant of cytochrome b5 reductase that causes methemoglobinemia shows the AMP moiety of the flavin occupying the substrate binding site. AN - 71361309; 14609324 AB - Methemoglobinemia, the first hereditary disease to be identified that involved an enzyme deficiency, has been ascribed to mutations in the enzyme cytochrome b(5) reductase. A variety of defects in either the erythrocytic or microsomal forms of the enzyme have been identified that give rise to the type I or type II variant of the disease, respectively. The positions of the methemoglobinemia-causing mutations are scattered throughout the protein sequence, but the majority of the nontruncated mutants that produce type II symptoms occur close to the flavin adenine dinucleotide (FAD) cofactor binding site. While X-ray structures have been determined for the soluble, flavin-containing diaphorase domains of the rat and pig enzymes, no X-ray or NMR structure has been described for the human enzyme or any of the methemoglobinemia variants. S127P, a mutant that causes type II methemoglobinemia, was the first to be positively identified and have its spectroscopic and kinetic properties characterized that revealed altered nicotinamide adenine dinucleotide hydride (NADH) substrate binding behavior. To understand these changes at a structural level, we have determined the structure of the S127P mutant of rat cytochrome b(5) reductase to 1.8 A resolution, providing the first structural snapshot of a cytochrome b(5) reductase mutant that causes methemoglobinemia. The high-resolution structure revealed that the adenosine diphosphate (ADP) moiety of the FAD prosthetic group is displaced into the corresponding ADP binding site of the physiological substrate, NADH, thus acting as a substrate inhibitor which is consistent with both the spectroscopic and kinetic data. JF - Biochemistry AU - Bewley, Maria C AU - Davis, C Ainsley AU - Marohnic, Christopher C AU - Taormina, David AU - Barber, Michael J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. mcb21@psu.edu Y1 - 2003/11/18/ PY - 2003 DA - 2003 Nov 18 SP - 13145 EP - 13151 VL - 42 IS - 45 SN - 0006-2960, 0006-2960 KW - Recombinant Proteins KW - 0 KW - NAD KW - 0U46U6E8UK KW - Flavin-Adenine Dinucleotide KW - 146-14-5 KW - Adenosine Monophosphate KW - 415SHH325A KW - Serine KW - 452VLY9402 KW - Proline KW - 9DLQ4CIU6V KW - Cytochrome-B(5) Reductase KW - EC 1.6.2.2 KW - Index Medicus KW - Animals KW - Recombinant Proteins -- chemical synthesis KW - Humans KW - Spectrophotometry, Ultraviolet KW - Substrate Specificity -- genetics KW - Recombinant Proteins -- genetics KW - Serine -- genetics KW - Proline -- genetics KW - Rats KW - NAD -- metabolism KW - Kinetics KW - Crystallography, X-Ray KW - Binding Sites -- genetics KW - Protein Conformation KW - Mutagenesis, Site-Directed KW - Cytochrome-B(5) Reductase -- metabolism KW - Cytochrome-B(5) Reductase -- genetics KW - Cytochrome-B(5) Reductase -- chemistry KW - Amino Acid Substitution -- genetics KW - Adenosine Monophosphate -- metabolism KW - Methemoglobinemia -- genetics KW - Flavin-Adenine Dinucleotide -- chemistry KW - Adenosine Monophosphate -- chemistry KW - Methemoglobinemia -- enzymology KW - Flavin-Adenine Dinucleotide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71361309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+structure+of+the+S127P+mutant+of+cytochrome+b5+reductase+that+causes+methemoglobinemia+shows+the+AMP+moiety+of+the+flavin+occupying+the+substrate+binding+site.&rft.au=Bewley%2C+Maria+C%3BDavis%2C+C+Ainsley%3BMarohnic%2C+Christopher+C%3BTaormina%2C+David%3BBarber%2C+Michael+J&rft.aulast=Bewley&rft.aufirst=Maria&rft.date=2003-11-18&rft.volume=42&rft.issue=45&rft.spage=13145&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-03-04 N1 - Date created - 2003-11-11 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Uptake and release of cesium-137 by five plant species as influenced by soil amendments in field experiments. AN - 71468923; 14674551 AB - Phytoextraction field experiments were conducted on soil contaminated with 0.39 to 8.7 Bq/g of 137Cs to determine the capacity of five plant species to accumulate 137Cs and the effects of three soil treatments on uptake. The plants tested were redroot pigweed (Amaranthus retroflexus L. var. aureus); a mixture of redroot pigweed and spreading pigweed (A. graecizans L.); purple amaranth (A. cruteus L.) x Powell's amaranth (A. powellii S. Watson), referred to here as the amaranth hybrid; Indian mustard [Brassica juncea (L.) Czern.]; and cabbage (Brassica oleracea L. var. capitata). For control plants, the concentration ratios (CR) of 137Cs were greatest for redroot pigweed and the amaranth hybrid, with average CR values of 1.0 +/- 0.24 and 0.95 +/- 0.14, respectively. The lowest value was for Indian mustard at 0.36 +/- 0.10. The soil treatments included (i) application of NH4NO3 solution to the soil after plants had matured, (ii) addition of composted manure to increase organic matter content of the soil, (iii) combination of the manure and ammonium solution treatments, and (iv) controls. The ammonium solution gave little overall increase in accumulation of 137Cs. The use of composted manure also had little influence, but the combination of the composted manure with application of ammonium solutions had a distinctly negative effect on plant uptake of 137Cs. On average the fraction of 137Cs taken up from the soil was reduced by 57.4 +/- 1.2% compared with controls. This was the result of release of competing ions, primarily Ca, from the manure and was observed across all five plant species tested. The application of ammonium solution took place in the last two weeks before harvest. The reduction of plant 137Cs content, by addition of the ammonium solution, as it interacted with the manure, indicates that substantial quantities 137Cs can be released from the shoots of plants as a result of sudden changes in soil solution chemistry. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Lasat, Mitch AU - Ebbs, Stephen AU - Cornish, Jay AU - Kochian, Leon AD - Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973-5000, USA. fuhrmann@bnl.gov PY - 2003 SP - 2272 EP - 2279 VL - 32 IS - 6 SN - 0047-2425, 0047-2425 KW - Cesium Radioisotopes KW - 0 KW - Manure KW - Nitrates KW - Soil Pollutants, Radioactive KW - ammonium nitrate KW - T8YA51M7Y6 KW - Index Medicus KW - Humans KW - Nitrates -- pharmacology KW - Conservation of Natural Resources KW - Cesium Radioisotopes -- pharmacokinetics KW - Amaranthus -- metabolism KW - Brassica -- metabolism KW - Soil Pollutants, Radioactive -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71468923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Uptake+and+release+of+cesium-137+by+five+plant+species+as+influenced+by+soil+amendments+in+field+experiments.&rft.au=Fuhrmann%2C+Mark%3BLasat%2C+Mitch%3BEbbs%2C+Stephen%3BCornish%2C+Jay%3BKochian%2C+Leon&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2003-11-01&rft.volume=32&rft.issue=6&rft.spage=2272&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-29 N1 - Date created - 2003-12-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - In situ high-pressure synchrotron X-ray powder diffraction study of tunnel manganese oxide minerals AN - 51812714; 2004-065455 AB - Microporous Mn oxides are valued for their catalytic, ion exchange, electrochemical, and adsorption properties. Of particular interest have been Mn-oxide catalysts with large tunnel structures; they exhibit a range of tunnel shapes and sizes that offer potential for complementary catalytic or cation-exchange applications. We used synchrotron powder X-ray diffraction to study structural changes with increasing pressure for three tunnel Mn oxide minerals. Experiments were performed using a Diamond Anvil Cell (DAC) at beamline X7A at the National Synchrotron Light Source, Brookhaven National Laboratory. Powdered samples of hollandite [(Ba (sub .75) ,Pb (sub .16) Na (sub .10) K (sub .04) )(Mn,Fe) (sub 8) O (sub 16) ], romanechite (Ba (sub .66) Mn (sub 5) O (sub 10) . 1.34H (sub 2) O), and todorokite [(Mg (sub .45) ,Na (sub .42) ,Ca (sub .15) )Mn (sub 6) O (sub 12) . 4H (sub 2) O] were, in turn, loaded into the DAC at ambient pressure and room temperature along with a few small ruby chips. A mixture of methanol:ethanol:water was used as a pressure transmitting fluid. The pressure at the sample was measured using the shift in the R1 emission line of the included ruby chips. Data were collected with a gas-proportional position-sensitive detector and radiation wavelength of 0.6839(1) Aa. Powder X-ray diffraction data were measured at pressure increments of 0.5-1.0 GPa between ambient pressure and 7 GPa; the samples were equilibrated for about 15 minutes or more at each measured pressure. A second set of measurements was made for each sample as the pressure was released. Unit-cell parameters were determined by whole pattern fitting using the LeBail method. The hollandite structure (I2/m) has tunnels with square cross-sections measuring 2 octahedra on an edge (2 X 2), and as pressure increased to approximately 3 GPa, the a-axis lengthened, b and c and unit-cell volume decreased, and beta increased. Above approximately 3 GPa, a started to decrease, and the slopes of the changes for the other parameters changed, suggesting a phase transition at about 3 GPa. Romanechite (C2/m) has 2 X 3 tunnels, and with increasing pressure all axial parameters and volume decreased and beta increased, exhibiting a slight change in slope at approximately 2 GPa. For the todorokite structure (P2/m), with 3 X 3 tunnels, the c-axis increased slightly below 1 GPa, but at higher pressures all of the axial parameters and unit-cell volume decreased and beta increased, consistent with a steady collapse of the tunnels. JF - Abstracts with Programs - Geological Society of America AU - Lee, Yongjae AU - Post, Jeffrey E AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 536 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - pressure KW - in situ KW - X-ray diffraction data KW - tunnel structures KW - phase transitions KW - crystal structure KW - powder method KW - high pressure KW - todorokite KW - laboratory studies KW - romanechite KW - manganese oxides KW - oxides KW - synchrotrons KW - anvil cells KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51812714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=In+situ+high-pressure+synchrotron+X-ray+powder+diffraction+study+of+tunnel+manganese+oxide+minerals&rft.au=Lee%2C+Yongjae%3BPost%2C+Jeffrey+E%3BAnonymous&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - anvil cells; crystal structure; experimental studies; high pressure; in situ; laboratory studies; manganese oxides; oxides; phase transitions; powder method; pressure; romanechite; synchrotrons; todorokite; tunnel structures; X-ray diffraction data ER - TY - JOUR T1 - Applications of crystal chemistry to mineral surface geochemistry AN - 51812274; 2004-065459 AB - Mineral surface geochemistry deals with the interaction of biological organisms and chemical species, including water, with mineral surfaces. The interaction of mineral surfaces with heavy metals and metalloids in aqueous solutions is of major interest because of the possibility they can sorb on mineral surfaces, which can effectively sequester them in specific pH ranges. XAFS spectroscopy studies have yielded quantitative information about the structures and modes of binding of cations and oxoanions at mineral/water interfaces. However, what is not known in most cases is the structure of the mineral surface in contact with water and how protons contribute to the stability of metal sorption complexes. Crystal chemical principles, including Pauling's bond valence principle, can be used to help constrain the types of surface sites to which metal(loid)s can bind, as well as the number of protons that can bind to a surface oxygen that is also bonded to a metal(loid) ion. In an extension of this approach, we have carried out grazing-incidence EXAFS studies of Pb(II) sorption on single crystal hematite surfaces in contact with water. Pb(II) was found to bind dominantly in an inner-sphere, bidentate fashion to FeO6 octahedra on the a-Fe2O3 (0001) and (1-102) surfaces, which is consistent with our earlier study of Pb(II) binding to a-Al2O3 (1-102) (J. Colloid Interface Sci. 1997, 85, 473). In contrast, we found that Pb(II) forms dominantly outer sphere complexes at the a-Al2O3 (0001)/water interface (Geochim. Cosmochim. Acta 1996, 60, 3541). In order to understand these differences in reactivity, we have recently carried out crystal truncation rod diffraction studies of these hydrated surfaces. This CTR work found significant structural differences between the (0001) surfaces of a-Fe2O3 and a-Al2O3, which helps explain their differences in reactivity to Pb(II). Application of crystal chemical principles to these metal/metal oxide systems, as well as to those in which AsO43- and SeO42- are aqueous sorbents, helps constrain their sorption behavior as well as proton release. JF - Abstracts with Programs - Geological Society of America AU - Brown, Gordon E AU - Bargar, John R AU - Trainor, Thomas P AU - Eng, Peter J AU - Fitts, Jeffrey P AU - Waychunas, Glenn A AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 536 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - colloidal materials KW - mineral-water interface KW - lead KW - crystal structure KW - bonding KW - hydration KW - chemical reactions KW - hematite KW - metals KW - EXAFS data KW - oxides KW - valency KW - crystal chemistry KW - mineral surface KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51812274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Applications+of+crystal+chemistry+to+mineral+surface+geochemistry&rft.au=Brown%2C+Gordon+E%3BBargar%2C+John+R%3BTrainor%2C+Thomas+P%3BEng%2C+Peter+J%3BFitts%2C+Jeffrey+P%3BWaychunas%2C+Glenn+A%3BAnonymous&rft.aulast=Brown&rft.aufirst=Gordon&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - bonding; chemical reactions; colloidal materials; crystal chemistry; crystal structure; EXAFS data; experimental studies; hematite; hydration; lead; metals; mineral surface; mineral-water interface; oxides; valency ER - TY - JOUR T1 - Inelastic X-ray scattering and X-ray diffraction study of graphite at high pressure AN - 51796191; 2004-073781 AB - Near K-edge features measured by x-ray absorption or electron energy loss spectroscopy provide rich information about the chemical bonding and have been used as quantitative tools to investigate a variety of carbon bonding in organic and inorganic materials. However, the low-energy x-ray and electron probes require vacuum environment, and are completely inaccessible, blocked by the pressure vessels for high-pressure studies, as the soft x-ray and electron beams. Synchrotron inelastic x-ray scattering (IXS) (also called x-ray Raman) spectroscopy, is capable of penetrating high pressure vessels and probing the bonding of samples at high-pressure in-situ. Although this technique was demonstrated almost forty years ago, it has only recently been successfully applied to ambient pressure studies. Compressed under ambient temperature, graphite undergoes a transition at approximately 17 GPa. The near K-edge spectroscopy of carbon using synchrotron x-ray inelastic scattering reveals that half of the pi-bonds between graphite layers convert to sigma-bonds while the other half remain as pi-bonds in the high-pressure form. The x-ray diffraction pattern of the high-pressure form, using He as a pressure transmitting medium, is consistent with a distorted graphite structure in which bridging carbon atoms between graphite layers pair and form sigma-bonds, while the non-bridging carbon atoms remain unpaired with dangling pi-bonds. The high-pressure form is superhard, capable of indenting cubic diamond single crystals. JF - Abstracts with Programs - Geological Society of America AU - Mao, Wendy L AU - Mao, Ho-kwang AU - Eng, Peter J AU - Trainor, Thomas P AU - Newville, Matthew AU - Kao, Chi-chang AU - Heinz, Dion L AU - Shu, Jinfu AU - Hemley, Russell J AU - Meng, Yue AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 622 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - pressure KW - X-ray diffraction data KW - crystal structure KW - native elements KW - high pressure KW - X-ray spectra KW - temperature KW - synchrotron radiation KW - laboratory studies KW - graphite KW - Raman spectra KW - spectra KW - compression KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51796191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Inelastic+X-ray+scattering+and+X-ray+diffraction+study+of+graphite+at+high+pressure&rft.au=Mao%2C+Wendy+L%3BMao%2C+Ho-kwang%3BEng%2C+Peter+J%3BTrainor%2C+Thomas+P%3BNewville%2C+Matthew%3BKao%2C+Chi-chang%3BHeinz%2C+Dion+L%3BShu%2C+Jinfu%3BHemley%2C+Russell+J%3BMeng%2C+Yue%3BAnonymous&rft.aulast=Mao&rft.aufirst=Wendy&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - compression; crystal structure; experimental studies; graphite; high pressure; laboratory studies; native elements; pressure; Raman spectra; spectra; synchrotron radiation; temperature; X-ray diffraction data; X-ray spectra ER - TY - JOUR T1 - Hydrogen exchange in Na-birnessite; a time-resolved synchrotron X-ray diffraction analysis AN - 51794639; 2004-073772 AB - Manganese oxide minerals having the birnessite-type layer structure occur in a wide variety of geological settings, including soils, Mn nodules, and rock varnishes. Mn oxides readily participate in cation-exchange and oxidation-reduction reactions, and because they typically form as coatings and fine-grained aggregates with large surface areas, even small quantities can significantly affect the chemical composition and behavior of sediments and associated aqueous systems. Additionally, because of their great chemical activity, synthetic birnessite-like phases are being extensively studied as possible catalysts, cation-exchange agents and battery materials. Of critical importance to the possible usage of birnessite as a cathodic material in solid-state batteries is its capacity to incorporate H ions during battery discharge. In this study, we examined the exchange of H for Na in birnessite in real time through synchrotron X-ray diffraction. Na-birnessite powders were exposed to HCl solutions (pH 3) at room temperature in a quartz capillary flow-through cell for approximately 1 hr, by which time H exchange was complete. Data were collected with an imaging plate, which allowed full-pattern diffraction patterns to be obtained every 2 minutes. Rietveld analyses of these time-resolved diffraction experiments confirm the proposition that endmember hexagonal H-birnessite appears and grows concomitant with the replacement of Na by H in the triclinic starting material (Drits et al. 1997). Hexagonal H-birnessite first was observed after 20 minutes of solution flow and increased in abundance (as revealed by refined weight fractions) linearly with time at the expense of the triclinic birnessite, which was not discernible after 60 minutes. Substitution of H into triclinic Na-birnessite was manifested by systematic decreases in the a, b, c, and beta lattice values beginning 10 minutes after fluid flow was initiated, contributing to a volume decrease of approximately 1%. Refined occupancies of the octahedral Mn in the hexagonal H-birnessite suggest that some Mn cations occupy the interlayer. JF - Abstracts with Programs - Geological Society of America AU - Heaney, Peter J AU - Post, Jeffrey E AU - Lopano, Christina L AU - Hanson, Jonathan C AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 620 EP - 621 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - experimental studies KW - X-ray diffraction data KW - Rietveld refinement KW - synchrotron radiation KW - birnessite KW - hydrogen KW - oxides KW - applications KW - Na-birnessite KW - ion exchange KW - crystal chemistry KW - industrial minerals KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51794639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Hydrogen+exchange+in+Na-birnessite%3B+a+time-resolved+synchrotron+X-ray+diffraction+analysis&rft.au=Heaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BLopano%2C+Christina+L%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Heaney&rft.aufirst=Peter&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - applications; birnessite; crystal chemistry; experimental studies; hydrogen; industrial minerals; ion exchange; Na-birnessite; oxides; Rietveld refinement; synchrotron radiation; X-ray diffraction data ER - TY - JOUR T1 - Scotian Shelf crossovers during winter/spring 1999 AN - 51771843; 2005-002103 JF - Journal of Geophysical Research AU - Smith, Peter C AU - Flagg, Charles N AU - Limeburner, Richard AU - Fuentes-Yaco, Cesar AU - Hannah, Charles AU - Beardsley, Robert C AU - Irish, James D AU - Lee, Craig M Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 31 PB - American Geophysical Union, Washington, DC VL - 108 IS - C11 SN - 0148-0227, 0148-0227 KW - currents KW - Browns Bank KW - ocean circulation KW - statistical analysis KW - salinity KW - satellite methods KW - ocean currents KW - tidal currents KW - measurement KW - tides KW - Georges Bank KW - Northeast Channel KW - seasonal variations KW - acoustic Doppler current profiler data KW - North Atlantic KW - Atlantic Ocean KW - Scotian Shelf KW - remote sensing KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51771843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Scotian+Shelf+crossovers+during+winter%2Fspring+1999&rft.au=Smith%2C+Peter+C%3BFlagg%2C+Charles+N%3BLimeburner%2C+Richard%3BFuentes-Yaco%2C+Cesar%3BHannah%2C+Charles%3BBeardsley%2C+Robert+C%3BIrish%2C+James+D%3BLee%2C+Craig+M&rft.aulast=Smith&rft.aufirst=Peter&rft.date=2003-11-01&rft.volume=108&rft.issue=C11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JC001288 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. 5 tables, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustic Doppler current profiler data; Atlantic Ocean; Browns Bank; currents; Georges Bank; measurement; North Atlantic; Northeast Channel; ocean circulation; ocean currents; remote sensing; salinity; satellite methods; Scotian Shelf; seasonal variations; statistical analysis; tidal currents; tides DO - http://dx.doi.org/10.1029/2001JC001288 ER - TY - JOUR T1 - Characterization of the mean and seasonal flow regime on Georges Bank from shipboard acoustic Doppler current profiler data AN - 51769938; 2005-002092 JF - Journal of Geophysical Research AU - Flagg, Charles N AU - Dunn, Maureen AU - Beardsley, Robert C AU - Smith, Peter C AU - Lee, Craig M Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 20 PB - American Geophysical Union, Washington, DC VL - 108 IS - C11 SN - 0148-0227, 0148-0227 KW - currents KW - ocean circulation KW - anticyclones KW - statistical analysis KW - ocean currents KW - least-squares analysis KW - tides KW - Great South Channel KW - Georges Bank KW - seasonal variations KW - acoustic Doppler current profiler data KW - North Atlantic KW - Atlantic Ocean KW - 07:Oceanography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51769938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Characterization+of+the+mean+and+seasonal+flow+regime+on+Georges+Bank+from+shipboard+acoustic+Doppler+current+profiler+data&rft.au=Flagg%2C+Charles+N%3BDunn%2C+Maureen%3BBeardsley%2C+Robert+C%3BSmith%2C+Peter+C%3BLee%2C+Craig+M&rft.aulast=Flagg&rft.aufirst=Charles&rft.date=2003-11-01&rft.volume=108&rft.issue=C11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JC001257 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 27 N1 - PubXState - DC N1 - Document feature - illus. incl. sketch map, sect. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - acoustic Doppler current profiler data; anticyclones; Atlantic Ocean; currents; Georges Bank; Great South Channel; least-squares analysis; North Atlantic; ocean circulation; ocean currents; seasonal variations; statistical analysis; tides DO - http://dx.doi.org/10.1029/2001JC001257 ER - TY - JOUR T1 - FTIR study of the effects of heterogeneity in water concentration on the origin of flow banded rhyolites AN - 51766584; 2004-085488 AB - This study focuses on the origin of flow-banded rhyolites that consist of darker and lighter flow bands that are not compositionally distinct magmas, but contrast in texture and color. Synchrotron-generated infrared radiation was used to obtain Fourier transform infrared (FTIR) spectra from which water concentrations were calculated, and to map variations in water concentrations across zones of spherules and glass from the 23 million year old Bartolo Mountain lava flow of southern Arizona. Lighter-colored, thicker flow bands consist of tan glass and large (2.5 to 5 mm) spherules. Darker-colored, thinner flow bands consist of brown glass and smaller (0.1 to 0.3 mm) spherules. Zones of orange glass separate lighter and darker flow bands. The center of the spherules is occupied by either 1) a quartz or sanidine crystal, 2) a granophyric intergrowth, or 3) (in some larger spherules) a void, suggesting that the spherule nucleated on a vapor bubble. In large spherules in the lighter bands, typically two zones of quartz/feldspar intergrowth radiate from the center of the spherule. The two zones are separated by a concentric zone of glass. Sanidine crystals that make up the cores of large spherules contain up to 250 ppm water. Inner radiating quartz/feldspar zones typically contain less ( approximately 2500 ppm) water than outer radiating quartz/feldspar zones ( approximately 3800 ppm). The transitional glass zones that separate the inner and outer zones contain to 7500 ppm water. Small spherules in darker bands have only one generation of radiating crystal growth. Water concentrations in small spherules range from a few hundred to approximately 1800 ppm. The orange glass that separates darker and lighter bands typically contains 1000-2000 ppm water. Overall the coarser-spherule, lighter-colored bands are much more water-rich than the finer-spherule, darker-colored bands, consistent with abundant water facilitating the growth of large spherules, and supporting the work of Hausback (1987), who suggested that flow banding may consist of alternating layers of stretched lithophysae, within which vapor phase crystallization occurred, and original less water-rich magma. Differences in original water concentration in the alternating layers resulted in differences in undercooling textures in spherules in the two types of flow bands. JF - Abstracts with Programs - Geological Society of America AU - Seaman, Sheila J AU - Dyar, M Darby AU - Marinkovic, Nebojsa AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 183 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - water KW - United States KW - rhyolites KW - petrology KW - Bartolo Mountain KW - volcanic rocks KW - textures KW - igneous rocks KW - infrared spectra KW - banded structures KW - FTIR spectra KW - mineral composition KW - Arizona KW - petrography KW - spectra KW - mineral assemblages KW - heterogeneity KW - flow texture KW - 05A:Igneous and metamorphic petrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51766584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=FTIR+study+of+the+effects+of+heterogeneity+in+water+concentration+on+the+origin+of+flow+banded+rhyolites&rft.au=Seaman%2C+Sheila+J%3BDyar%2C+M+Darby%3BMarinkovic%2C+Nebojsa%3BAnonymous&rft.aulast=Seaman&rft.aufirst=Sheila&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2004-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Arizona; banded structures; Bartolo Mountain; flow texture; FTIR spectra; heterogeneity; igneous rocks; infrared spectra; mineral assemblages; mineral composition; petrography; petrology; rhyolites; spectra; textures; United States; volcanic rocks; water ER - TY - JOUR T1 - Effect of arsenic substitution on pyrite oxidation in bituminous coal samples; experiments and spectroscopic monitors AN - 51717143; 2005-039247 AB - Trace-constituent substitution in pyrite is an important factor that may affect its stability during oxidation of coal-bearing strata and waste from coal washing operations. Arsenic, the most abundant trace/minor constituent in pyrite, is thought to have a de-stabilizing effect, as indicated by previous XAFS studies showing oxidation of pyritic arsenic to arsenate in advance of significant iron oxidation. In this study, we exposed coal samples with differing amounts of pyrite and differing extents of arsenic substitution in pyrite, to controlled experimental conditions. Samples investigated include a Springfield coal from Indiana (whole coal pyritic S = 2.13 wt. %; As in pyrite=detection limit to 0.06 wt. %), two Pittsburgh coal samples from West Virginia (pyritic S = 1.32 to 1.58 wt. %; As in pyrite = d.l. to 0.34 wt. %), and two samples from the Warrior Basin, Alabama (pyritic S = 0.26 to 0.27 wt. %; As in pyrite = d.l. to 2.72 wt. %). Samples were collected from active mine faces and selected for expected differences in pyritic arsenic, confirmed by electron microprobe analysis. Splits of each sample are being exposed to four room-temperature experimental conditions over a period of 1-2 years, including: 1) dry argon atmosphere; 2) dry oxygen atmosphere; 3) room atmosphere (relative humidity approximately 20 to 60 %), and 4) room atmosphere with samples wetted periodically with double-distilled water. The extent of arsenic and iron oxidation is monitored by arsenic XAFS spectroscopy and iron Moessbauer spectroscopy. Arsenic XANES spectra for each coal sample, obtained after the first month of study, show major peaks for pyritic arsenic and minor peaks for arsenate forms. Least-squares fitting of the spectra shows little difference among equivalent samples stored under different atmospheres. However, the wetted samples showed significant formation of arsenate. Moessbauer spectroscopy also showed significant differences between samples stored under argon and those periodically wetted, but much less change with the other environments. The initial results show that arsenate formation can be induced and monitored, allowing comparison of oxidation progress in the test coal samples. JF - Abstracts with Programs - Geological Society of America AU - Kolker, Allan AU - Huggins, Frank E AU - Khalid, Syed AU - Fedorko, Nick AU - Mastalerz, Maria AU - Carroll, Richard E AU - Anonymous Y1 - 2003/11// PY - 2003 DA - November 2003 SP - 482 PB - Geological Society of America (GSA), Boulder, CO VL - 35 IS - 6 SN - 0016-7592, 0016-7592 KW - United States KW - Pittsburgh Coal KW - Pennsylvanian KW - coal fields KW - environmental analysis KW - Alabama KW - bituminous coal KW - electron probe data KW - sedimentary rocks KW - mineral composition KW - sampling KW - coal KW - spectra KW - chemical composition KW - geochemistry KW - West Virginia KW - Mossbauer spectra KW - experimental studies KW - monitoring KW - pollutants KW - Paleozoic KW - oxidation KW - Warrior coal field KW - Carboniferous KW - arsenic KW - XAFS spectra KW - pollution KW - X-ray spectra KW - metals KW - pyrite KW - sulfides KW - 06B:Petrology of coal KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51717143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Effect+of+arsenic+substitution+on+pyrite+oxidation+in+bituminous+coal+samples%3B+experiments+and+spectroscopic+monitors&rft.au=Kolker%2C+Allan%3BHuggins%2C+Frank+E%3BKhalid%2C+Syed%3BFedorko%2C+Nick%3BMastalerz%2C+Maria%3BCarroll%2C+Richard+E%3BAnonymous&rft.aulast=Kolker&rft.aufirst=Allan&rft.date=2003-11-01&rft.volume=35&rft.issue=6&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2005-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - Alabama; arsenic; bituminous coal; Carboniferous; chemical composition; coal; coal fields; electron probe data; environmental analysis; experimental studies; geochemistry; metals; mineral composition; monitoring; Mossbauer spectra; oxidation; Paleozoic; Pennsylvanian; Pittsburgh Coal; pollutants; pollution; pyrite; sampling; sedimentary rocks; spectra; sulfides; United States; Warrior coal field; West Virginia; X-ray spectra; XAFS spectra ER - TY - JOUR T1 - Neuroimaging in drug abuse. AN - 73664627; 13678555 AB - Neuroimaging techniques, including positron emission tomography (PET), are ideally suited for studies of addiction. These minimally invasive modalities yield information about acute and long-term drug-induced structural and functional changes in the brain over time. Changes can be observed in the brains of human and animal subjects during drug self-administration. Neuroimaging with PET allows precise quantification and visualization of the drug and its rates of movement in the body. In addition, imaging reveals recovery of function and reappearance of neuronal markers in abstinent drug users. Evidence that suggests that PET may have use in identifying individuals predisposed to become addicted is emerging. Finally, candidate pharmacotherapies for drug addiction can be critically evaluated. These unique assets clearly point to the use of these strategies for addiction studies. JF - Current psychiatry reports AU - Lindsey, Kimberly P AU - Gatley, S John AU - Volkow, Nora D AD - Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY 11973, USA. lindsey@bnl.gov Y1 - 2003/10// PY - 2003 DA - October 2003 SP - 355 EP - 361 VL - 5 IS - 5 SN - 1523-3812, 1523-3812 KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Tomography, Emission-Computed KW - Substance-Related Disorders -- therapy KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73664627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+psychiatry+reports&rft.atitle=Neuroimaging+in+drug+abuse.&rft.au=Lindsey%2C+Kimberly+P%3BGatley%2C+S+John%3BVolkow%2C+Nora+D&rft.aulast=Lindsey&rft.aufirst=Kimberly&rft.date=2003-10-01&rft.volume=5&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Current+psychiatry+reports&rft.issn=15233812&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-01-06 N1 - Date created - 2003-09-18 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Low monoamine oxidase B in peripheral organs in smokers AN - 18882611; 5738599 AB - One of the major mechanisms for terminating the actions of catecholamines and vasoactive dietary amines is oxidation by monoamine oxidase (MAO). Smokers have been shown to have reduced levels of brain MAO, leading to speculation that MAO inhibition by tobacco smoke may underlie some of the behavioral and epidemiological features of smoking. Because smoking exposes peripheral organs as well as the brain to MAO-inhibitory compounds, we questioned whether smokers would also have reduced MAO levels in peripheral organs. Here we compared MAO B in peripheral organs in nonsmokers and smokers by using positron emission tomography and serial scans with the MAO B-specific radiotracers,L- [ super(11)C]deprenyl and deuterium-substituted L-[ super(11)C]deprenyl (L- [ super(11)C]deprenyl-D2). Binding specificity was assessed by using the deuterium isotope effect. We found that smokers have significantly reduced MAO B in peripheral organs, particularly in the heart, lungs, and kidneys, when compared with nonsmokers. Reductions ranged from 33% to 46%. Because MAO B breaks down catecholamines and other physiologically active amines, including those released by nicotine, its inhibition may alter sympathetic tone as well as central neurotransmitter activity, which could contribute to the medical consequences of smoking. In addition, although most of the emphases on the carcinogenic properties of smoke have been placed on the lungs and the upper airways, this finding highlights the fact that multiple organs in the body are also exposed to pharmacologically significant quantities of chemical compounds in tobacco smoke. JF - Proceedings of the National Academy of Sciences, USA AU - Fowler, J S AU - Logan, J AU - Wang, G-J AU - Volkow, N D AU - Telang, F AU - Zhu, W AU - Franceschi, D AU - Pappas, N AU - Ferrieri, R AU - Shea, C AU - Garza, V AU - Xu, Y AU - Schlyer, D AU - Gatley, S J AU - Ding, Y-S AU - Alexoff, D AU - Warner, D AU - Netusil, N AU - Carter, P AU - Jayne, M AU - King, P AU - Vaska, P AD - Chemistry Department and Medical Department, Brookhaven National Laboratory, Upton, NY 11973, fowler@bnl.gov Y1 - 2003/09/30/ PY - 2003 DA - 2003 Sep 30 SP - 11600 EP - 11605 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 100 IS - 20 SN - 0027-8424, 0027-8424 KW - man KW - Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18882611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Low+monoamine+oxidase+B+in+peripheral+organs+in+smokers&rft.au=Fowler%2C+J+S%3BLogan%2C+J%3BWang%2C+G-J%3BVolkow%2C+N+D%3BTelang%2C+F%3BZhu%2C+W%3BFranceschi%2C+D%3BPappas%2C+N%3BFerrieri%2C+R%3BShea%2C+C%3BGarza%2C+V%3BXu%2C+Y%3BSchlyer%2C+D%3BGatley%2C+S+J%3BDing%2C+Y-S%3BAlexoff%2C+D%3BWarner%2C+D%3BNetusil%2C+N%3BCarter%2C+P%3BJayne%2C+M%3BKing%2C+P%3BVaska%2C+P&rft.aulast=Fowler&rft.aufirst=J&rft.date=2003-09-30&rft.volume=100&rft.issue=20&rft.spage=11600&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.1833106100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1073/pnas.1833106100 ER - TY - JOUR T1 - Role of Vitamin D receptor gene in radiation-induced neoplastic transformation of human breast epithelial cell. AN - 73622621; 12957667 AB - 1 Alpha,25-(OH)(2)-Vitamin D(3), the physiologically active metabolite of Vitamin D is known for its pro-differentiating and antiproliferative activity on various cancer cell lines. It exerts its growth-regulatory effects through binding to the Vitamin D recepter (VDR), a member of the steroid/thyroid/retinoic acid receptor family, which functions as a ligand-dependent transcription factor. There is accumulating evidence that Vitamin D may be an important determinant of both the occurrence and progression of breast cancer. Since radiation is an important etiological factor for breast cancer progression, it is important to study the role of VDR gene in radiation-induced breast carcinogenesis. This study is focused on a human breast tumor model developed by irradiating the spontaneously immortalized MCF-10F cell line with graded doses of high-linear energy transfer (LET) radiation followed by treatment with estrogen. Study of VDR gene by restriction digestion with ApaI, BsmI and TaqI detected no polymorphism but direct sequencing analyses identified few single-base mutations within intron 8 and exon 9 of the gene. Over-expression of the VDR gene was noticed in irradiated and tumorigenic cell lines compared with control. Likewise, immunohistochemical data indicated a significant increase in VDR intensity in irradiated and tumorigenic cell lines. Considering all these evidence, it is likely that VDR can be used as a prognostic marker of tumor progression in radiation- and estrogen-induced breast carcinogenesis. JF - Steroids AU - Roy, Debasish AU - Calaf, Gloria AU - Hei, Tom K AD - Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. droy@bnl.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 621 EP - 627 VL - 68 IS - 7-8 SN - 0039-128X, 0039-128X KW - Biomarkers, Tumor KW - 0 KW - Estrogens KW - Neoplasm Proteins KW - Receptors, Calcitriol KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - DNA Mutational Analysis KW - Humans KW - Prognosis KW - Mutation, Missense KW - Gene Expression Regulation, Neoplastic KW - Epithelial Cells -- chemistry KW - Estrogens -- pharmacology KW - Epithelial Cells -- pathology KW - Neoplasm Proteins -- genetics KW - Biomarkers, Tumor -- analysis KW - Cell Line, Transformed KW - Neoplasm Proteins -- analysis KW - Female KW - Receptors, Calcitriol -- genetics KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- diagnosis KW - Cell Transformation, Neoplastic -- radiation effects KW - Cell Transformation, Neoplastic -- chemistry KW - Receptors, Calcitriol -- analysis KW - Breast Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73622621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Steroids&rft.atitle=Role+of+Vitamin+D+receptor+gene+in+radiation-induced+neoplastic+transformation+of+human+breast+epithelial+cell.&rft.au=Roy%2C+Debasish%3BCalaf%2C+Gloria%3BHei%2C+Tom+K&rft.aulast=Roy&rft.aufirst=Debasish&rft.date=2003-09-01&rft.volume=68&rft.issue=7-8&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Steroids&rft.issn=0039128X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-05-26 N1 - Date created - 2003-09-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Security Risk Analysis for Chemical Process Facilities AN - 19140772; 5749743 AB - In response to the events of September 11, many companies stepped up security efforts in chemical process facilities and other installations. Since resources are limited, a system for ranking relative risk would be useful in establishing priorities for implementing physical-security infrastructure and programs. This paper presents the elements of a relative risk assessment that can augment conventional process hazard analysis (PHA). This assessment is based on categorizing threat, vulnerability, and the consequences of deliberate actions by terrorists, disgruntled employees, and others. JF - Process Safety Progress AU - Lemley, J R AU - Fthenakis, V M AU - Moskowitz, P D AD - Brookhaven National Laboratory, Building 830, P.O. Box 5000, Upton, NY 11973-5000, USA, vmf@bnl.gov Y1 - 2003/09// PY - 2003 DA - Sep 2003 SP - 153 EP - 162 VL - 22 IS - 3 SN - 0278-4513, 0278-4513 KW - security KW - terrorism KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Chemical process industry KW - Emergency preparedness KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19140772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+Progress&rft.atitle=Security+Risk+Analysis+for+Chemical+Process+Facilities&rft.au=Lemley%2C+J+R%3BFthenakis%2C+V+M%3BMoskowitz%2C+P+D&rft.aulast=Lemley&rft.aufirst=J&rft.date=2003-09-01&rft.volume=22&rft.issue=3&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Process+Safety+Progress&rft.issn=02784513&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chemical process industry; Emergency preparedness; Risk assessment ER - TY - JOUR T1 - Nesting Ecology and Predation of Diamondback Terrapins, Malaclemys terrapin, at Gateway National Recreation Area, New York AN - 18938205; 5712597 AB - We studied Diamondback terrapins, Malaclemys terrapin, at Gateway National Recreation Area, New York. We found evidence of nesting terrapins at three locations within the Recreation Area and focused our research on the islands of Jamaica Bay Wildlife Refuge. Female terrapins nested from early June through early August and oviposited at least two clutches per year. Mean clutch size was 10.9 eggs. Nesting activity increased with daily high temperature and high tide. The greatest number of terrapin nests was found in shrubland, dune, and mixed-grassland habitats, but nest densities were higher on a human-made sandy trail and on sandy beaches. We estimate that approximately 2053 nests were oviposited on the largest island in the refuge in 1999. In 1998 and 1999, we counted 1319 and 1840 depredated nests, respectively, throughout the refuge. Raccoons were introduced into Jamaica Bay Wildlife Refuge approximately 20 yr prior to this study. Raccoons depredated 92.2% of nests monitored on the largest island during the 1999 nesting season. We also found the carcasses of adult female terrapins that apparently were killed by raccoons as they came on land to nest. This terrapin population may be undergoing demographic changes as a result of the introduction of raccoons. JF - Journal of Herpetology AU - Feinberg, JA AU - Burke, R L AD - U.S. Fish and Wildlife Service, Brookhaven National Laboratory, 81 Cornell Avenue, Building 120, Upton, New York 11973, USA, jfeinberg@bnl.gov Y1 - 2003/09// PY - 2003 DA - September 2003 SP - 517 EP - 526 PB - The Society for the Study of Amphibians and Reptiles VL - 37 IS - 3 SN - 0022-1511, 0022-1511 KW - Diamondback terrapin KW - Raccoon KW - ASFA 1: Biological Sciences & Living Resources; Animal Behavior Abstracts; Ecology Abstracts KW - Nesting behavior KW - Beaches KW - Recreation sites KW - Predation KW - Aquatic reptiles KW - Predators KW - Freshwater KW - USA, New York, Long I., Jamaica Bay, Jamaica Bay Natl. Wildlife refuge KW - USA, New York KW - Islands KW - Malaclemys terrapin KW - Breeding sites KW - Nesting KW - Procyon lotor KW - Reproductive behaviour KW - Introduced species KW - USA, New York, Gateway Natl. Recreation area KW - Y 25424:Vertebrates (excluding fish, birds & mammals) KW - Q1 08423:Behaviour KW - D 04670:Reptiles KW - Q1 08324:Reproduction and development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18938205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Herpetology&rft.atitle=Nesting+Ecology+and+Predation+of+Diamondback+Terrapins%2C+Malaclemys+terrapin%2C+at+Gateway+National+Recreation+Area%2C+New+York&rft.au=Feinberg%2C+JA%3BBurke%2C+R+L&rft.aulast=Feinberg&rft.aufirst=JA&rft.date=2003-09-01&rft.volume=37&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+Herpetology&rft.issn=00221511&rft_id=info:doi/10.1043%2F0022-1511%282003%29037%280517%3ANEAPOD%292.0.CO%3B2 LA - English DB - ProQuest Environmental Science Collection N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Beaches; Islands; Breeding sites; Nesting; Aquatic reptiles; Predators; Reproductive behaviour; Introduced species; Nesting behavior; Recreation sites; Predation; Malaclemys terrapin; Procyon lotor; USA, New York, Long I., Jamaica Bay, Jamaica Bay Natl. Wildlife refuge; USA, New York, Gateway Natl. Recreation area; USA, New York; Freshwater DO - http://dx.doi.org/10.1043/0022-1511(2003)037(0517:NEAPOD)2.0.CO;2 ER - TY - JOUR T1 - Abnormal brain activation to visual stimulation in cocaine abusers. AN - 73537160; 12899920 AB - Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level dependent] responses to activation stimuli. Here, we used fMRI to compared the BOLD response to photic visual stimulation in neurologically intact active cocaine abusers to that in non-drug-using healthy controls. Cocaine abusers showed a significantly enhanced positive BOLD response to photic stimulation when compared to control subjects. The enhanced activation in the cocaine abusers could result from low resting cerebral blood flow secondary to increased vasoconstriction and/or from low oxidative metabolism during activation. Alternatively, the larger signal intensity in the cocaine abusers could result from inefficient neuronal processing as has been shown to occur in other conditions of cerebral pathology. These findings provide evidence of cerebral dysfunction with chronic cocaine abuse, which could reflect cerebral blood flow or neuronal changes. Further studies are required to determine if the cerebrovascular changes we observed in the cocaine abusers recover with detoxification and to assess their functional consequences. JF - Life sciences AU - Lee, Jing-Huei AU - Telang, Frank W AU - Springer, Charles S AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Y1 - 2003/08/29/ PY - 2003 DA - 2003 Aug 29 SP - 1953 EP - 1961 VL - 73 IS - 15 SN - 0024-3205, 0024-3205 KW - Narcotics KW - 0 KW - Cocaine KW - I5Y540LHVR KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Photic Stimulation KW - Brain Mapping KW - Visual Cortex -- physiology KW - Evoked Potentials, Visual KW - Oxygen -- blood KW - Humans KW - Blood Flow Velocity -- drug effects KW - Adult KW - Visual Cortex -- blood supply KW - Middle Aged KW - Magnetic Resonance Angiography -- methods KW - Image Processing, Computer-Assisted KW - Male KW - Cocaine-Related Disorders -- diagnosis KW - Cerebrovascular Circulation -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Narcotics -- adverse effects KW - Cocaine-Related Disorders -- blood KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73537160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Life+sciences&rft.atitle=Abnormal+brain+activation+to+visual+stimulation+in+cocaine+abusers.&rft.au=Lee%2C+Jing-Huei%3BTelang%2C+Frank+W%3BSpringer%2C+Charles+S%3BVolkow%2C+Nora+D&rft.aulast=Lee&rft.aufirst=Jing-Huei&rft.date=2003-08-29&rft.volume=73&rft.issue=15&rft.spage=1953&rft.isbn=&rft.btitle=&rft.title=Life+sciences&rft.issn=00243205&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-03 N1 - Date created - 2003-08-05 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Response of rat skin to high-dose unidirectional x-ray microbeams: a histological study. AN - 73479435; 12859223 AB - There is growing interest in evaluating microbeam radiation therapy as a potential clinical modality. Microbeam radiation therapy uses arrays of parallel, microscopically thin (<100 microm) planes of synchrotron-generated X rays (microplanar beams, or microbeams). Due to the relatively low beam energies involved in microbeam radiation therapy (a median beam energy of 120 keV was used in the present study), the dose penetration of microbeams in tissue is lower than that used in conventional radiotherapy. This lower energy necessitates using a significantly elevated dose to the skin's surface during clinical microbeam therapy to ensure an adequate dose distribution in the target tumor. The findings of the present study, using a rat skin model, indicated that the skin had an extremely high tolerance to microbeam radiation at doses considerably in excess of those that were therapeutically effective in preclinical studies. A histological study was undertaken to evaluate the biological mechanisms underlying this high tolerance. The irradiation configuration employed single-exposure, unidirectional microbeams 90 microm wide, with 300 microm beam spacing on-center. The in-beam skin-surface absorbed doses were in the range 835-1335 Gy. Monte Carlo simulations of the dose distribution indicated that the "valley" dose, i.e. the radiation leakage between adjacent microbeams, was about 2.5% of the in-beam dose. The high tolerance of the rats' skin to microbeams and the rapid regeneration of the damaged segments of skin were attributed to the surviving clonogenic cells situated between the adjacent microplanar beams. In the epidermis, clonogenic cells in the hair follicular epithelium appeared to play a key role in the regeneration process. JF - Radiation research AU - Zhong, Nan AU - Morris, Gerard M AU - Bacarian, Tigran AU - Rosen, Eliot M AU - Dilmanian, F Avraham AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 133 EP - 142 VL - 160 IS - 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Radiation Dosage KW - Reference Values KW - Hindlimb -- cytology KW - Epidermis -- cytology KW - Radiation Tolerance KW - Dose-Response Relationship, Radiation KW - Rats KW - X-Rays KW - Rats, Inbred F344 KW - Hair Follicle -- radiation effects KW - Hair Follicle -- cytology KW - Hindlimb -- radiation effects KW - Epidermis -- radiation effects KW - Male KW - Skin -- radiation effects KW - Skin -- pathology KW - Skin -- cytology KW - Radiometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73479435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Response+of+rat+skin+to+high-dose+unidirectional+x-ray+microbeams%3A+a+histological+study.&rft.au=Zhong%2C+Nan%3BMorris%2C+Gerard+M%3BBacarian%2C+Tigran%3BRosen%2C+Eliot+M%3BDilmanian%2C+F+Avraham&rft.aulast=Zhong&rft.aufirst=Nan&rft.date=2003-08-01&rft.volume=160&rft.issue=2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-08 N1 - Date created - 2003-07-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A crystal structure for the souzalite/gormanite series from synchrotron powder diffraction data AN - 51937472; 2003-070564 AB - In absence of suitable single crystal due to polysynthetic twinning, the crystal structure of a specimen in the souzalite/gormanite series (Fe,Mg) (sub 3) (Al,Fe) (sub 4) (PO (sub 4) ) (sub 4) (OH) (sub 6) .2H (sub 2) O is determined ab initio from synchrotron powder diffraction data. The crystals belong to space group P1, the cell is different from previously reported with a = 7.2223(1), b = 11.7801(1), c = 5.1169(1) Aa; alpha = 90.158(1), beta = 109.938(1), gamma = 81.330(1) degrees ; V = 404.02(1) Aa (super 3) ; Z = 1. The structure consists of infinite chains of alternating [FeO (sub 6) ], [MgO (sub 6) ] and [AlO (sub 6) ] octahedra sharing faces and/or edges. These chains are connected by corners with clusters of three corner-sharing [AlO (sub 6) ] octahedra, forming octahedral layers which are interconnected by [PO (sub 4) ] groups. A comparison with other minerals of similar composition and structure is made (dufrenite, burangaite). JF - European Journal of Mineralogy AU - Le Bail, Armel AU - Stephens, Peter W AU - Hubert, Francis Y1 - 2003/08// PY - 2003 DA - August 2003 SP - 719 EP - 723 PB - Schweizerbart'sche Verlagsbuchhandlung (Naegele u. Obermiller), Stuttgart VL - 15 IS - 4 SN - 0935-1221, 0935-1221 KW - X-ray diffraction data KW - unit cell KW - souzalite KW - crystal structure KW - phosphates KW - bonding KW - Yukon Territory KW - Rietveld refinement KW - gormanite KW - synchrotron radiation KW - hydroxyl ion KW - Canada KW - Rapid Creek Yukon Territory KW - Western Canada KW - lattice parameters KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51937472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Mineralogy&rft.atitle=A+crystal+structure+for+the+souzalite%2Fgormanite+series+from+synchrotron+powder+diffraction+data&rft.au=Le+Bail%2C+Armel%3BStephens%2C+Peter+W%3BHubert%2C+Francis&rft.aulast=Le+Bail&rft.aufirst=Armel&rft.date=2003-08-01&rft.volume=15&rft.issue=4&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Mineralogy&rft.issn=09351221&rft_id=info:doi/10.1127%2F0935-1221%2F2003%2F0015-0719 L2 - http://www.schweizerbart.de/j/ejm/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bonding; Canada; crystal structure; gormanite; hydroxyl ion; lattice parameters; phosphates; Rapid Creek Yukon Territory; Rietveld refinement; souzalite; synchrotron radiation; unit cell; Western Canada; X-ray diffraction data; Yukon Territory DO - http://dx.doi.org/10.1127/0935-1221/2003/0015-0719 ER - TY - JOUR T1 - Increased plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in lung and breast cancer are altered during chest radiotherapy. AN - 73418758; 12829155 AB - PURPOSEDoes the release of plasma matrix metalloproteinase-9 (MMP-9) by radiation-activated airway epithelial cells and infiltrating inflammatory cells play a role in the radiation damage or repair process in the lungs? We evaluated lung damage by ionizing radiation using plasma levels of MMP-9, tissue inhibitor of metalloproteinase-1 (TIMP-1), and MMP-3 as biologic markers of tissue damage, and also their relationship to changes in pulmonary epithelial permeability, clinical signs and symptoms, and lung structural changes.METHODS AND MATERIALSSeven serial studies were conducted in each of 8 patients undergoing chest radiotherapy (RT) for lung or breast cancer, beginning before the first treatment (baseline) and then biweekly to approximately 100 days during and after RT. Chest radiographs were monitored for each patient. Sandwich enzyme-linked immunoassays (ELISA) were used to measure plasma MMP-3, MMP-9, and TIMP-1 levels. Lung permeability was evaluated by measuring the rate of epithelial clearance of approximately 150 microCi ( approximately 5.6 MBq) inhaled (99m)Tc diethylenetriamine pentaacetate aerosol (DTPA).RESULTSLung and breast cancer resulted in very high plasma levels of MMP-9 (126-893 ng/mL) and TIMP-1 (496-8985 ng/mL) in all subjects studied before initiation of RT. This compares with plasma MMP-9 and TIMP-1 values in healthy volunteers of 29 +/- 11 ng/mL and 436 +/- 86 ng/mL, respectively. RT was followed by a sharp decrease in plasma MMP-9 within the first 2 weeks, but without a corresponding change in TIMP-1. In contrast, plasma MMP-3 levels, which are generally increased with inflammation, were elevated in only 1 of 5 subjects.CONCLUSIONLung and breast cancer are associated with high plasma levels of MMP-9 and TIMP-1. These high baseline plasma levels of MMP-9 were reduced in the first 2 weeks of RT in 7 of 8 subjects, and TIMP-1 plasma levels remained high in all subjects. The decrease in plasma MMP-9 after initiation of chest RT appears to reflect a suppressive effect on cancer-induced cellular responses rather than a primary role for MMP-9 in radiation-induced lung damage. Likewise, the lack of a rise in plasma MMP-3 levels does not support a role for MMP-3 in tissue injury or repair in the lung. It remains to be determined whether plasma MMP-9 measurements will serve as a useful parameter in predicting cancer relapse. JF - International journal of radiation oncology, biology, physics AU - Susskind, Herbert AU - Hymowitz, Michelle H AU - Lau, Yat Hong AU - Atkins, Harold L AU - Hurewitz, Adam N AU - Valentine, Edward S AU - Meek, Allen G AU - Zucker, Stanley AD - Clinical Research Center, Brookhaven National Laboratory, Upton, NY 11973, USA. Hssusski@optonline.net Y1 - 2003/07/15/ PY - 2003 DA - 2003 Jul 15 SP - 1161 EP - 1169 VL - 56 IS - 4 SN - 0360-3016, 0360-3016 KW - Tissue Inhibitor of Metalloproteinase-1 KW - 0 KW - Matrix Metalloproteinase 3 KW - EC 3.4.24.17 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Lung -- diagnostic imaging KW - Humans KW - Aged KW - Lung -- metabolism KW - Radiation Injuries -- blood KW - Radiotherapy -- adverse effects KW - Radionuclide Imaging KW - Epithelial Cells -- radiation effects KW - Epithelial Cells -- metabolism KW - Radiation Injuries -- diagnostic imaging KW - Technetium Tc 99m Pentetate -- pharmacokinetics KW - Cell Membrane Permeability -- radiation effects KW - Middle Aged KW - Radiography KW - Matrix Metalloproteinase 3 -- blood KW - Radiation Injuries -- enzymology KW - Female KW - Male KW - Lung -- radiation effects KW - Lung Neoplasms -- enzymology KW - Lung Neoplasms -- radiotherapy KW - Matrix Metalloproteinase 9 -- blood KW - Lung Neoplasms -- blood KW - Tissue Inhibitor of Metalloproteinase-1 -- blood KW - Breast Neoplasms -- enzymology KW - Breast Neoplasms -- radiotherapy KW - Breast Neoplasms -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73418758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Increased+plasma+levels+of+matrix+metalloproteinase-9+and+tissue+inhibitor+of+metalloproteinase-1+in+lung+and+breast+cancer+are+altered+during+chest+radiotherapy.&rft.au=Susskind%2C+Herbert%3BHymowitz%2C+Michelle+H%3BLau%2C+Yat+Hong%3BAtkins%2C+Harold+L%3BHurewitz%2C+Adam+N%3BValentine%2C+Edward+S%3BMeek%2C+Allen+G%3BZucker%2C+Stanley&rft.aulast=Susskind&rft.aufirst=Herbert&rft.date=2003-07-15&rft.volume=56&rft.issue=4&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-31 N1 - Date created - 2003-06-27 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sub-chronic low dose gamma-vinyl GABA (vigabatrin) inhibits cocaine-induced increases in nucleus accumbens dopamine. AN - 73508670; 12684739 AB - RATIONALEgamma-Vinyl GABA (GVG) irreversibly inhibits GABA-transaminase. This non-receptor mediated inhibition requires de novo synthesis for restoration of functional GABA catabolism.OBJECTIVESGiven its preclinical success for treating substance abuse and the increased risk of visual field defects (VFD) associated with cumulative lifetime exposure, we explored the effects of sub-chronic low dose GVG on cocaine-induced increases in nucleus accumbens (NAcc) dopamine (DA).METHODSUsing in vivo microdialysis, we compared acute exposure (450 mg/kg) to an identical sub-chronic exposure (150 mg/kg per day for 3 days), followed by 1- or 3-day washout. Finally, we examined the low dose of 150 mg/kg (50 mg/kg per day) using a similar washout period.RESULTSSub-chronic GVG exposure inhibited the effect of cocaine for 3 days, which exceeded in magnitude and duration the identical acute dose.CONCLUSIONSSub-chronic low dose GVG potentiates and extends the inhibition of cocaine-induced increases in dopamine, effectively reducing cumulative exposures and the risk for VFDS. JF - Psychopharmacology AU - Schiffer, Wynne K AU - Marsteller, Douglas AU - Dewey, Stephen L AD - Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794, USA. wynne@bnl.gov Y1 - 2003/07// PY - 2003 DA - July 2003 SP - 339 EP - 343 VL - 168 IS - 3 SN - 0033-3158, 0033-3158 KW - 4-Aminobutyrate Transaminase KW - EC 2.6.1.19 KW - Vigabatrin KW - GR120KRT6K KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Time Factors KW - Male KW - Vigabatrin -- pharmacology KW - Nucleus Accumbens -- drug effects KW - 4-Aminobutyrate Transaminase -- antagonists & inhibitors KW - Vigabatrin -- administration & dosage KW - Cocaine-Related Disorders -- drug therapy KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73508670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Sub-chronic+low+dose+gamma-vinyl+GABA+%28vigabatrin%29+inhibits+cocaine-induced+increases+in+nucleus+accumbens+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BMarsteller%2C+Douglas%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-07-01&rft.volume=168&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-02-10 N1 - Date created - 2003-07-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Could X-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery? AN - 71550505; 14984714 AB - BACKGROUNDParallel, thin (<100 microm) planes of synchrotron-generated X rays, have been shown to spare normal tissues and preferentially damage tumors in animal models. The aim of the present study was to assess the effect of such microbeams directed unidirectionally on angioplasted rat carotid arteries.METHODS AND MATERIALSThree groups of Sprague-Dawley rats were studied: (a) rats with normal, untreated arteries, (b) rats treated by balloon angioplasty, but not irradiated, and (c) rats treated with balloon angioplasty and exposed to single fraction, unidirectional, parallel, microbeams an hour after angioplasty. The microbeam array, 15 mm widex7.6 mm high, consisting of 27-microm-wide beam slices, spaced 200 microm center-to-center laterally traversed the damaged artery. The in-depth in-beam dose was 150 Gy, the "valley" dose (dose midway between microbeams resulting mainly from X-ray scattering) was 4.5 Gy on average, and the "integrated" (averaged) dose was 26 Gy.RESULTSMicrobeam irradiation, as given in the present study, was tolerated, but was insufficient to significantly suppress the neointimal hyperplasia.DISCUSSIONThe microbeam dose used is considered low. Dose escalation would be necessary to reach conclusive results regarding the X-ray microbeam efficacy to control restenosis. JF - Cardiovascular radiation medicine AU - Dilmanian, F A AU - Kalef-Ezra, J AU - Petersen, M J AU - Bozios, G AU - Vosswinkel, J AU - Giron, F AU - Ren, B AU - Yakupov, R AU - Antonakopoulos, G AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. PY - 2003 SP - 139 EP - 145 VL - 4 IS - 3 SN - 1522-1865, 1522-1865 KW - Index Medicus KW - Rats KW - Models, Cardiovascular KW - Animals KW - X-Rays KW - Rats, Sprague-Dawley KW - Tunica Intima -- radiation effects KW - Hyperplasia -- etiology KW - Disease Models, Animal KW - Dose-Response Relationship, Radiation KW - Tunica Intima -- pathology KW - Hyperplasia -- radiotherapy KW - Carotid Artery, Common -- radiation effects KW - Carotid Artery, Common -- pathology KW - Angioplasty, Balloon -- adverse effects KW - Carotid Stenosis -- therapy KW - Graft Occlusion, Vascular -- etiology KW - Carotid Artery, Common -- surgery KW - Graft Occlusion, Vascular -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71550505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+radiation+medicine&rft.atitle=Could+X-ray+microbeams+inhibit+angioplasty-induced+restenosis+in+the+rat+carotid+artery%3F&rft.au=Dilmanian%2C+F+A%3BKalef-Ezra%2C+J%3BPetersen%2C+M+J%3BBozios%2C+G%3BVosswinkel%2C+J%3BGiron%2C+F%3BRen%2C+B%3BYakupov%2C+R%3BAntonakopoulos%2C+G&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=2003-07-01&rft.volume=4&rft.issue=3&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+radiation+medicine&rft.issn=15221865&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2004-11-08 N1 - Date created - 2004-02-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Evidence linking the Pseudomonas oleovorans alkane omega-hydroxylase, an integral membrane diiron enzyme, and the fatty acid desaturase family. AN - 73376494; 12804773 AB - Pseudomonas oleovorans alkane omega-hydroxylase (AlkB) is an integral membrane diiron enzyme that shares a requirement for iron and oxygen for activity in a manner similar to that of the non-heme integral membrane desaturases, epoxidases, acetylenases, conjugases, ketolases, decarbonylase and methyl oxidases. No overall sequence similarity is detected between AlkB and these desaturase-like enzymes by computer algorithms; however, they do contain a series of histidine residues in a similar relative positioning with respect to hydrophobic regions thought to be transmembrane domains. To test whether these conserved histidine residues are functionally equivalent to those of the desaturase-like enzymes we used scanning alanine mutagenesis to test if they are essential for activity of AlkB. These experiments show that alanine substitution of any of the eight conserved histidines results in complete inactivation, whereas replacement of three non-conserved histidines in close proximity to the conserved residues, results in only partial inactivation. These data provide the first experimental support for the hypotheses: (i) that the histidine motif in AlkB is equivalent to that in the desaturase-like enzymes and (ii) that the conserved histidine residues play a vital role such as coordinating the Fe ions comprising the diiron active site. JF - FEBS letters AU - Shanklin, John AU - Whittle, Edward AD - Department of Biology, Brookhaven National Laboratory, Building 463, 50 Bell Ave., Upton, NY 11973, USA. shanklin@bnl.gov Y1 - 2003/06/19/ PY - 2003 DA - 2003 Jun 19 SP - 188 EP - 192 VL - 545 IS - 2-3 SN - 0014-5793, 0014-5793 KW - Bacterial Proteins KW - 0 KW - Membrane Proteins KW - Histidine KW - 4QD397987E KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Iron KW - E1UOL152H7 KW - Mixed Function Oxygenases KW - EC 1.- KW - Cytochrome P-450 CYP4A KW - EC 1.14.15.3 KW - Fatty Acid Desaturases KW - EC 1.14.19.- KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Histidine -- chemistry KW - Pseudomonas -- enzymology KW - Conserved Sequence KW - Amino Acid Motifs KW - Alanine -- metabolism KW - Histidine -- genetics KW - Point Mutation KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Amino Acid Substitution KW - Bacterial Proteins -- genetics KW - Mixed Function Oxygenases -- metabolism KW - Fatty Acid Desaturases -- chemistry KW - Fatty Acid Desaturases -- genetics KW - Bacterial Proteins -- chemistry KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Fatty Acid Desaturases -- metabolism KW - Bacterial Proteins -- metabolism KW - Iron -- chemistry KW - Cytochrome P-450 Enzyme System -- metabolism KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73376494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Evidence+linking+the+Pseudomonas+oleovorans+alkane+omega-hydroxylase%2C+an+integral+membrane+diiron+enzyme%2C+and+the+fatty+acid+desaturase+family.&rft.au=Shanklin%2C+John%3BWhittle%2C+Edward&rft.aulast=Shanklin&rft.aufirst=John&rft.date=2003-06-19&rft.volume=545&rft.issue=2-3&rft.spage=188&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-25 N1 - Date created - 2003-06-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Alcohol intoxication induces greater reductions in brain metabolism in male than in female subjects. AN - 73419104; 12824811 AB - BACKGROUNDThe mechanisms underlying the gender differences in alcohol drinking behavior and alcohol's effects are poorly understood and may reflect gender differences in brain neurochemistry. Alcohol decreases glucose metabolism in the human brain in a pattern that is consistent with its facilitation of GABAergic neurotransmission. We compared the regional changes in brain glucose metabolism during alcohol intoxication between female and male subjects.METHODSTen female and 10 male healthy controls were scanned with positron emission tomography and 2-deoxy-2[18F]fluoro-D-glucose twice: 40 min after placebo (diet soda) or alcohol (0.75 g/kg mixed with diet soda).RESULTSAlcohol significantly and consistently decreased whole-brain metabolism. The magnitude of these changes was significantly larger in male (-25 +/- 6%) than in female (-14 +/- 11%; p < 0.005) subjects. Half of the female subjects had reductions in metabolism during intoxication that were significantly lower than those in male subjects. This blunted response in the female subjects was not due to differences in alcohol concentration in plasma, because these did not differ between the genders. In contrast, the self-reports for the perception of intoxication were significantly greater in female than in male subjects. The cognitive deterioration during alcohol intoxication, although not significant, tended to be worse in female subjects.CONCLUSIONSThis study shows a markedly blunted sensitivity to the effects of acute alcohol on brain glucose metabolism in female subjects that may reflect gender differences in alcohol's modulation of GABAergic neurotransmission. The greater behavioral effects of alcohol in female subjects despite the blunted metabolic responses could reflect other effects of alcohol, for which the regional metabolic signal may be hidden within the large decrements in metabolism that occur during alcohol intoxication. JF - Alcoholism, clinical and experimental research AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Fowler, Joanna S AU - Franceschi, Dinko AU - Wong, Christopher T AU - Pappas, Naomi R AU - Netusil, Noelwah AU - Zhu, Wei AU - Felder, Christoph AU - Ma, Yeming AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 909 EP - 917 VL - 27 IS - 6 SN - 0145-6008, 0145-6008 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Analysis of Variance KW - Humans KW - Adult KW - Middle Aged KW - Statistics, Nonparametric KW - Male KW - Female KW - Tomography, Emission-Computed -- methods KW - Sex Characteristics KW - Brain -- drug effects KW - Brain -- metabolism KW - Alcoholic Intoxication -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73419104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Alcohol+intoxication+induces+greater+reductions+in+brain+metabolism+in+male+than+in+female+subjects.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BFranceschi%2C+Dinko%3BWong%2C+Christopher+T%3BPappas%2C+Naomi+R%3BNetusil%2C+Noelwah%3BZhu%2C+Wei%3BFelder%2C+Christoph%3BMa%2C+Yeming&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2003-06-01&rft.volume=27&rft.issue=6&rft.spage=909&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-10-21 N1 - Date created - 2003-06-25 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Neutron and temperature-resolved synchrotron X-ray powder diffraction study of akaganeite AN - 51961496; 2003-051817 AB - Rietveld refinements using neutron powder diffraction data were used to locate H atom positions and obtain a more precise crystal structure refinement for akaganeite [Fe (super 3+) (sub 7.6) Ni (super 2+) (sub 0.4) O (sub 6.35) (OH) (sub 9.65) Cl (sub 1.25) .nH (sub 2) O]. Difference Fourier maps clearly showed H atoms positions near those O atoms at the midpoints of the tunnel edges. The O-H vectors point toward the Cl sites at the center of the tunnel, and weak hydrogen bonds likely form between the framework O atoms and Cl. The Cl position is near the center of a prism defined by the eight hydroxy1 H atoms. The Cl atoms fill approximately 2/3 of the tunnel sites, suggesting an ordering scheme in a given tunnel with every third tunnel site vacant. Such an arrangement allows the Cl anions to increase their separation distance along a tunnel by displacing away from one another toward their respective adjacent vacancies. The Fe-O octahedra in akaganeite are distorted with Fe-(O, OH) distances ranging from 1.94 to 2.13 Aa and show three longer and three shorter Fe-O distances; as expected the longer distances are associated with the OH-anions. Temperature-resolved synchrotron X-ray powder diffraction data and Rietveld refinements were used to investigate changes in the akaganeite structure and its transformation into hematite as it was heated from 26 to 800 degrees C. Rietveld refinements revealed surprising consistency in all unit-cell parameters between room temperature and approximately 225 degrees C, resulting in nearly zero thermal expansion of the akaganeite structure over a 200 degrees C interval. Above approximately 225 degrees C, the unit-cell volume gradually decreased, primarily in response to decreases in c and b, and an increase in the beta angle. The a parameter remained nearly constant until approximately 225 degrees C and increased thereafter. Akaganeite started to transform to hematite in the temperature range 290 to 310 degrees C with no evidence for maghemite as an intermediate phase. JF - American Mineralogist AU - Post, Jeffrey E AU - Heaney, Peter J AU - Von Dreele, Robert B AU - Hanson, Jonathan C Y1 - 2003/06// PY - 2003 DA - June 2003 SP - 782 EP - 788 PB - Mineralogical Society of America, Washington, DC VL - 88 IS - 5-6 SN - 0003-004X, 0003-004X KW - refinement KW - X-ray diffraction data KW - akaganeite KW - unit cell KW - oxides KW - crystal structure KW - bonding KW - Rietveld refinement KW - P-T conditions KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51961496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Neutron+and+temperature-resolved+synchrotron+X-ray+powder+diffraction+study+of+akaganeite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BVon+Dreele%2C+Robert+B%3BHanson%2C+Jonathan+C&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2003-06-01&rft.volume=88&rft.issue=5-6&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 26 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - akaganeite; bonding; crystal structure; oxides; P-T conditions; refinement; Rietveld refinement; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Highlights of PET studies on chiral radiotracers and drugs at Brookhaven AN - 20641635; 7761733 AB - We review several PET studies of chiral molecules which have been carried out in our laboratory. In many cases the enantiomers behave differently, reflecting factors such as differential specificity for enzymes and transporters and binding to plasma proteins, as well as selective binding to receptors. These studies demonstrate that PET imaging is a suitable method to investigate the behavior of a chiral drug in the human body and is a powerful tool in drug development. It is important to emphasize the essential and pivotal role that organic synthesis has played in the development of PET during the last quarter century. PET is now an important tool in the neurosciences, cardiology, and oncology and is available in hundreds of institutions worldwide. However, PET is by no means mature in terms of the study of chiral drugs; hundreds of racemic drugs have been developed but only a few have been labeled with positron emitters to study their stereoselectivity. One reason is the complexity of rapid synthesis, including chiral synthesis and chiral purification. New developments in these areas are needed. Although PET is a challenging and expensive technology, it is exquisitely suited to functional and neurochemical studies of the human brain and other organs. Its use in drug research and development holds promise in understanding duration of action and stereoselectivity of drugs and in facilitating drug discovery and the introduction of new drugs into the practice of medicine. JF - Drug Development Research AU - Ding, Yu-Shin AU - Fowler, Joanna S AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York, ding@bnl.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 227 EP - 239 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0272-4391, 0272-4391 KW - Biotechnology Research Abstracts (through 1992) KW - Plasma proteins KW - Drug discovery KW - Neuroimaging KW - Enantiomers KW - Brain KW - Positron emission tomography KW - Enzymes KW - Oncology KW - Drug development KW - Stereoselectivity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20641635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Highlights+of+PET+studies+on+chiral+radiotracers+and+drugs+at+Brookhaven&rft.au=Ding%2C+Yu-Shin%3BFowler%2C+Joanna+S&rft.aulast=Ding&rft.aufirst=Yu-Shin&rft.date=2003-06-01&rft.volume=59&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.10221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Positron emission tomography; Drug development; Stereoselectivity; Drug discovery; Plasma proteins; Neuroimaging; Brain; Enzymes; Enantiomers; Oncology DO - http://dx.doi.org/10.1002/ddr.10221 ER - TY - JOUR T1 - Positron emission tomography and its use to image the occupancy of drug binding sites AN - 20416914; 7761731 AB - The development of positron emission tomography (PET) and the ability to synthesize compounds labeled with the short-lived positron emitters 11C and 18F has made possible the imaging and quantification of drug binding sites in the human body. By conducting PET studies with an appropriate radioligand iefore and after treatment with a drug, the fraction of the total number of binding sites that is occupied by the drug (the occupancy of the site) can often be determined. To the extent that occupancy is a good indicator of pharmacological activity, such PET experiments can aid the development of drug dosage regimens. Some of the general issues involved in PET studies of drug occupancy are discussed. There have been many such studies involving antipsychotic drugs and dopamine D2 receptor radioligands. Since neuroleptics have been extensively reviewed elsewhere, only the major findings are discussed here. Other binding sites (and drug classes) in the dopamine system to which this methodology has been applied include: the dopamine transporter (stimulant drugs) and monoamine oxidase A and B (antidepressant drugs). Occupancy studies are also possible for many drug targets beyond the dopamine system. JF - Drug Development Research AU - Gatley, S John AU - Volkow, Nora D AU - Fowler, Joanna S AU - Ding, Yu-Shin AU - Logan, Jean AU - Wang, Gene-Jack AU - Gifford, Andrew N AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York, gatley@bnl.gov Y1 - 2003/06// PY - 2003 DA - Jun 2003 SP - 194 EP - 207 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 59 IS - 2 SN - 0272-4391, 0272-4391 KW - Biotechnology Research Abstracts (through 1992); CSA Neurosciences Abstracts KW - Dopamine D2 receptors KW - Amine oxidase (flavin-containing) KW - Stimulants KW - Drug development KW - Antidepressants KW - Dopamine transporter KW - Reviews KW - Neuroleptics KW - Positron emission tomography KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20416914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Positron+emission+tomography+and+its+use+to+image+the+occupancy+of+drug+binding+sites&rft.au=Gatley%2C+S+John%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BDing%2C+Yu-Shin%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BGifford%2C+Andrew+N&rft.aulast=Gatley&rft.aufirst=S&rft.date=2003-06-01&rft.volume=59&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.10219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Positron emission tomography; Drug development; Dopamine D2 receptors; Neuroleptics; Stimulants; Antidepressants; Reviews; Dopamine transporter; Amine oxidase (flavin-containing) DO - http://dx.doi.org/10.1002/ddr.10219 ER - TY - JOUR T1 - The addicted human brain: insights from imaging studies. AN - 73282290; 12750391 JF - The Journal of clinical investigation AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AD - Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 1444 EP - 1451 VL - 111 IS - 10 SN - 0021-9738, 0021-9738 KW - Street Drugs KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Nerve Net -- physiopathology KW - Magnetic Resonance Imaging KW - Animals KW - Reward KW - Motivation KW - Disease Susceptibility KW - Memory -- drug effects KW - Humans KW - Nerve Net -- drug effects KW - Tomography, Emission-Computed KW - Learning -- drug effects KW - Primates KW - Substance-Related Disorders -- physiopathology KW - Brain -- physiopathology KW - Substance-Related Disorders -- diagnosis KW - Street Drugs -- pharmacology KW - Brain -- drug effects KW - Street Drugs -- adverse effects KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73282290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=The+addicted+human+brain%3A+insights+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-05-01&rft.volume=111&rft.issue=10&rft.spage=1444&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-06-04 N1 - Date created - 2003-05-16 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2787-8 [9096295] Behav Brain Res. 2002 Dec 2;137(1-2):75-114 [12445717] Science. 1997 Oct 3;278(5335):45-7 [9311924] Neuron. 1997 Sep;19(3):591-611 [9331351] Pharmacol Biochem Behav. 1998 Feb;59(2):287-93 [9476972] Am J Psychiatry. 1998 Aug;155(8):1009-15 [9699686] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] Life Sci. 1999;64(9):775-84 [10075110] Eur J Pharmacol. 1999 Jun 30;375(1-3):13-30 [10443561] Am J Psychiatry. 1999 Sep;156(9):1440-3 [10484959] J Pharmacol Exp Ther. 1999 Oct;291(1):409-15 [10490931] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Cereb Cortex. 2000 Mar;10(3):272-84 [10731222] Cereb Cortex. 2000 Mar;10(3):284-94 [10731223] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Life Sci. 2000 Feb 11;66(12):PL161-7 [10737368] Addiction. 2000 Aug;95 Suppl 2:S119-28 [11002907] Prog Brain Res. 2000;126:217-29 [11105649] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] Biol Psychiatry. 2001 Jan 15;49(2):81-96 [11164755] Synapse. 2001 Mar 1;39(3):257-66 [11169774] J Neurosci. 2001 Jan 15;21(2):RC121 [11160455] Brain Res Mol Brain Res. 2001 Feb 19;87(1):124-43 [11223167] Nat Rev Neurosci. 2001 Feb;2(2):119-28 [11252991] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] Am J Psychiatry. 2001 Mar;158(3):390-8 [11229979] Annu Rev Neurosci. 2001;24:167-202 [11283309] Arch Gen Psychiatry. 2001 Apr;58(4):334-41 [11296093] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4728-33 [11274349] J Neurosci. 2001 Apr 15;21(8):2799-807 [11306632] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5300-5 [11320258] J Neurosci. 2001 Jun 1;21(11):4090-103 [11356897] Biol Psychiatry. 2001 Jun 1;49(11):894-905 [11377407] Exp Brain Res. 2001 Aug;139(3):278-86 [11545466] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Nat Rev Neurosci. 2001 Oct;2(10):695-703 [11584307] J Addict Dis. 2001;20(3):43-54 [11681592] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Nat Neurosci. 2002 Feb;5(2):169-74 [11802171] Biol Psychiatry. 2002 Jan 15;51(2):134-42 [11822992] Neuropsychologia. 2002;40(10):1675-89 [11992656] J Neurosci. 2002 Jul 15;22(14):6247-53 [12122083] Nat Rev Drug Discov. 2002 Sep;1(9):710-26 [12209151] Synapse. 2002 Nov;46(2):79-82 [12211085] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] J Neurochem. 2002 Aug;82(4):721-35 [12358778] Neuron. 2002 Oct 10;36(2):229-40 [12383779] Synapse. 1993 Jun;14(2):169-77 [8101394] Psychopharmacology (Berl). 1994 Aug;115(4):441-6 [7871087] Arch Gen Psychiatry. 2002 Dec;59(12):1162-72 [12470133] Am J Psychiatry. 2003 Jan;160(1):33-40 [12505799] Science. 1988 Nov 4;242(4879):715-23 [2903550] Am J Psychiatry. 1991 May;148(5):621-6 [2018164] Synapse. 1992 Jul;11(3):184-90 [1636149] Arch Gen Psychiatry. 1992 Sep;49(9):739-44 [1514879] J Nucl Med. 1995 Jul;36(7):1182-90 [7790942] Nature. 1996 Feb 22;379(6567):733-6 [8602220] Addiction. 1996 Jul;91(7):921-49; discussion 951-65 [8688822] Behav Pharmacol. 2002 Sep;13(5-6):355-66 [12394411] J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):377-405 [12426407] Nature. 1997 Apr 24;386(6627):830-3 [9126741] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy. AN - 73250728; 12710874 AB - Microbeam radiation therapy is an experimental modality using parallel arrays of thin (<100 micro m) slices of synchrotron-generated X rays (microplanar beams, microbeams). We used EMT-6 murine mammary carcinoma subcutaneously inoculated in the hind legs of mice to compare the therapeutic efficacies of single-fraction, unidirectional (1) "co-planar" microbeams (an array of vertically oriented microplanar beams), (2) "cross-planar" microbeams (two arrays of parallel microbeams propagated in the same direction, one with vertically and the other with horizontally oriented microplanar beams), and (3) seamless (broad) beams from the same synchrotron source. The microbeams were 90 micro m wide and were spaced 300 micro m on center; the median energy in all beams was 100 or 118 keV. Tumor ablation rates were 4/8, 4/8 and 6/7 for a 410-, 520- and 650-Gy in-slice cross-planar microbeam dose, respectively, and 1/8, 3/8, 3/7 and 6/8 for a 23-, 30-, 38- and 45-Gy broad-beam dose, respectively. When the data were pooled from the three highest doses (same average tumor ablations of 50-60%), the incidences of normal-tissue acute toxicity (moist desquamation and epilation) and delayed toxicity (failure of hair regrowth) were significantly lower for cross-planar microbeams than broad beams (P < 0.025). Furthermore, for the highest doses in these two groups, which also had the same tumor ablation rate (>75%), not only were the above toxicities lower for the cross-planar microbeams than for the broad beams (P < 0.02), but severe leg dysfunction was also lower (P < 0.003). These findings suggest that single-fraction microbeams can ablate tumors at high rates with relatively little normal-tissue toxicity. JF - Radiation research AU - Dilmanian, F Avraham AU - Morris, Gerard M AU - Zhong, Nan AU - Bacarian, Tigran AU - Hainfeld, James F AU - Kalef-Ezra, John AU - Brewington, Laura J AU - Tammam, Jennifer AU - Rosen, Eliot M AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Dilmanian@bnl.gov Y1 - 2003/05// PY - 2003 DA - May 2003 SP - 632 EP - 641 VL - 159 IS - 5 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Animals KW - Synchrotrons KW - Radiotherapy Dosage KW - Radiation Tolerance KW - Mice KW - Mice, Inbred BALB C KW - Female KW - X-Ray Therapy -- adverse effects KW - X-Ray Therapy -- methods KW - Mammary Neoplasms, Experimental -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73250728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Murine+EMT-6+carcinoma%3A+high+therapeutic+efficacy+of+microbeam+radiation+therapy.&rft.au=Dilmanian%2C+F+Avraham%3BMorris%2C+Gerard+M%3BZhong%2C+Nan%3BBacarian%2C+Tigran%3BHainfeld%2C+James+F%3BKalef-Ezra%2C+John%3BBrewington%2C+Laura+J%3BTammam%2C+Jennifer%3BRosen%2C+Eliot+M&rft.aulast=Dilmanian&rft.aufirst=F&rft.date=2003-05-01&rft.volume=159&rft.issue=5&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-29 N1 - Date created - 2003-04-24 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Positron emission tomography and single-photon emission computed tomography in substance abuse research. AN - 73284943; 12756644 AB - Many advances in the conceptualization of addiction as a disease of the brain have come from the application of imaging technologies directly in the human drug abuser. New knowledge has been driven by advances in radiotracer design and chemistry and positron emission tomography (PET) and single-photon emission computed tomography (SPECT) instrumentation and the integration of these scientific tools with the tools of biochemistry, pharmacology, and medicine. This topic cuts across the medical specialties of neurology, psychiatry, oncology, and cardiology because of the high medical, social, and economic toll that drugs of abuse, including the legal drugs, cigarettes and alcohol, take on society. This article highlights recent advances in the use of PET and SPECT imaging to measure the pharmacokinetic and pharmacodynamic effects of drugs of abuse on the human brain. JF - Seminars in nuclear medicine AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AD - Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 114 EP - 128 VL - 33 IS - 2 SN - 0001-2998, 0001-2998 KW - Street Drugs KW - 0 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Tomography, Emission-Computed, Single-Photon -- methods KW - Humans KW - Brain -- drug effects KW - Brain -- metabolism KW - Brain -- diagnostic imaging KW - Street Drugs -- pharmacology KW - Substance-Related Disorders -- etiology KW - Street Drugs -- adverse effects KW - Dopamine -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Street Drugs -- metabolism KW - Tomography, Emission-Computed -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73284943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+nuclear+medicine&rft.atitle=Positron+emission+tomography+and+single-photon+emission+computed+tomography+in+substance+abuse+research.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2003-04-01&rft.volume=33&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Seminars+in+nuclear+medicine&rft.issn=00012998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-09-10 N1 - Date created - 2003-05-20 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Rapid analytical technique to identify alpha emitting isotopes in water, air-filters, urine, and solid matrices using a Frisch Grid detector. AN - 73204371; 12705448 AB - A 5-inch-diameter Frisch Grid gas-proportional ionization chamber was utilized at Brookhaven National Laboratory (BNL) to rapidly characterize and quantify alpha-emitting actinides in unprocessed water, soil, air-filter, urine, and solid matrices. Instrument calibrations for the various matrices were performed by spiking representative samples with National Institute of Standards and Technology traceable isotopes of 230Th, 232U, 236Pu, and 243Am. Detection efficiencies were typically 15-20% for solid matrices (soil, concrete, filters, dry urine) and 45% for mass-less water samples. Instrument background over a 512-channel alpha-energy range of 3-8 MeV is very low at 0.01 cps. At optimum efficiency, minimum detectable levels of 0.56 mBq Kg(-1), 74 mBq L(-1) and 14.8 mBq filter(-1) were achievable for 40 x 10(-6) Kg soil, 1 x 10(-3) L tap water (or urine), and 4.5 cm diameter air-filter samples, respectively, each counted for 60 min. Data and spectra are presented showing the quality of results obtained using untreated samples obtained from the BNL Graphite Research Reactor Decommissioning Project. These samples contained Bq to MBq per gram amounts of (239,240)Pu, 241Am, and/or (234,235/238)U (as well as other beta/gamma emitters). Data and spectra are also presented for a very finely pulverized and homogeneous U.S. DOE/RESL soil reference standard (spiked with 239Pu, 241Am, and 233U) that was used to assess precision, accuracy, and reproducibility. Although this technique has its limitations, the advantages are (1) minimal sample preparation, (2) no separation chemistry required, (3) no chemical or hazardous waste generated, and (4) ability to immediately characterize and quantify alpha-emitting nuclides in most matrices. The benefits of this technique to the BNL/DOE Project Managers were rapid (1-2 d) turn-around times coupled with significant cost savings, as compared to commercial off-site analyses. JF - Health physics AU - Scarpitta, Salvatore C AU - Miltenberger, Robert P AU - Gaschott, Robert AU - Carte, Nina AD - Brookhaven National Laboratory, Upton, NY 11973, USA. scarpitta@bnl.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 492 EP - 501 VL - 84 IS - 4 SN - 0017-9078, 0017-9078 KW - Air Pollutants, Radioactive KW - 0 KW - Dust KW - Radioactive Pollutants KW - Soil Pollutants, Radioactive KW - Water Pollutants, Radioactive KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Transducers KW - Dust -- analysis KW - Reference Standards KW - Water Pollutants, Radioactive -- analysis KW - Calibration -- standards KW - Background Radiation KW - Equipment Design KW - Chemistry Techniques, Analytical -- methods KW - Equipment Failure Analysis KW - Air Pollutants, Radioactive -- analysis KW - Chemistry Techniques, Analytical -- instrumentation KW - Quality Control KW - Urine -- chemistry KW - Soil Pollutants, Radioactive -- analysis KW - Radiometry -- instrumentation KW - Radioactive Pollutants -- analysis KW - Alpha Particles KW - Radiometry -- methods KW - Radiation Monitoring UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/73204371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Rapid+analytical+technique+to+identify+alpha+emitting+isotopes+in+water%2C+air-filters%2C+urine%2C+and+solid+matrices+using+a+Frisch+Grid+detector.&rft.au=Scarpitta%2C+Salvatore+C%3BMiltenberger%2C+Robert+P%3BGaschott%2C+Robert%3BCarte%2C+Nina&rft.aulast=Scarpitta&rft.aufirst=Salvatore&rft.date=2003-04-01&rft.volume=84&rft.issue=4&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-29 N1 - Date created - 2003-04-22 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Selegiline potentiates cocaine-induced increases in rodent nucleus accumbens dopamine. AN - 72985593; 12557270 AB - Selegiline has been proposed as a treatment for cocaine addiction and studies in humans suggest that it attenuates cocaine's reinforcing effects. Here we assessed the effects of selegiline treatment on cocaine-induced increases in nucleus accumbens (NAc) dopamine (DA) in freely moving rodents. Chronic treatment with selegiline (L-deprenyl, 0.25/mg/kg, 24 days) potentiated cocaine-induced increases in NAc DA from 350-600%. However, this enhanced response was abolished when animals were treated chronically with both cocaine and selegiline. Inasmuch as increases in NAc DA are associated with the reinforcing effects of cocaine, these results obtained in rodents suggest that MAO-A and -B inhibition may not be a suitable strategy to antagonize cocaine's reinforcing effects during cocaine detoxification. On the other hand, chronic selegiline treatment may improve DA deficits, which are thought to contribute to relapse through a decreased response to natural rewards. JF - Synapse (New York, N.Y.) AU - Schiffer, Wynne K AU - Azmoodeh, Manijeh AU - Gerasimov, Madina AU - Volkow, Nora D AU - Fowler, Joanna S AU - Dewey, Stephen L AD - Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA. wynne@bnl.gov Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 35 EP - 38 VL - 48 IS - 1 SN - 0887-4476, 0887-4476 KW - Dopamine Uptake Inhibitors KW - 0 KW - Neuroprotective Agents KW - Selegiline KW - 2K1V7GP655 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Drug Synergism KW - Time Factors KW - Male KW - Selegiline -- pharmacology KW - Dopamine -- metabolism KW - Dopamine -- analysis KW - Cocaine -- pharmacology KW - Neuroprotective Agents -- pharmacology KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72985593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Selegiline+potentiates+cocaine-induced+increases+in+rodent+nucleus+accumbens+dopamine.&rft.au=Schiffer%2C+Wynne+K%3BAzmoodeh%2C+Manijeh%3BGerasimov%2C+Madina%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BDewey%2C+Stephen+L&rft.aulast=Schiffer&rft.aufirst=Wynne&rft.date=2003-04-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-23 N1 - Date created - 2003-01-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - 3D GPR polarization analysis for imaging complex objects AN - 50871591; 2005-046627 JF - Proceedings of SAGEEP AU - Daniels, Jeffrey J AU - Wielopolski, Lucian AU - Radzevicius, Stan AU - Bookshar, Jess AU - Anonymous Y1 - 2003/04// PY - 2003 DA - April 2003 SP - 585 EP - 597 PB - Environmental and Engineering Geophysical Society, Wheat Ridge, CO VL - 2003 KW - polarization KW - imagery KW - three-dimensional models KW - ground-penetrating radar KW - geophysical methods KW - radar methods KW - mathematical models KW - detection KW - identification KW - electromagnetic methods KW - applications KW - buried features KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50871591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+SAGEEP&rft.atitle=3D+GPR+polarization+analysis+for+imaging+complex+objects&rft.au=Daniels%2C+Jeffrey+J%3BWielopolski%2C+Lucian%3BRadzevicius%2C+Stan%3BBookshar%2C+Jess%3BAnonymous&rft.aulast=Daniels&rft.aufirst=Jeffrey&rft.date=2003-04-01&rft.volume=2003&rft.issue=&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+SAGEEP&rft.issn=1554-8015&rft_id=info:doi/ L2 - http://scitation.aip.org/sageep/ LA - English DB - GeoRef N1 - Conference title - Symposium on The application of geophysics to engineering and environmental problems N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 6 N1 - PubXState - CO N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - applications; buried features; detection; electromagnetic methods; geophysical methods; ground-penetrating radar; identification; imagery; mathematical models; polarization; radar methods; three-dimensional models ER - TY - JOUR T1 - Synthesis of Structurally Identical Fluorine-18 and Iodine Isotope Labeling Compounds for Comparative Imaging AN - 18748766; 5621472 AB - The synthesis of a benzophenone-based labeling compound designed for comparative imaging studies with both in vivo positron emission tomograph (PET) and single-photon computed tomography (SPECT) and ex vivo autoradiography is described. The new compound can be labeled with either F-18 or iodine radioisotopes to give two different radioisotopmers: N-[2-fluoro-5-(3-[I-131]iodobenzoyl)benzyl]-2-bromoacetamide (1) and N-[2-[F-18]fluoro-5-(3-iodobenzoyl)benzyl]-2-bromoacetamide (2). Compound 1 and 2 have a 2-bromoacetyl group, which can be used to conjugate with biomolecules through a nucleophilic substitution reaction. Compound 1 was synthesized from the corresponding tributyltin derivatives via an oxidative destannylation reaction, and compound 2 was prepared via a four-step radiosynthesis (nucleophilic aromatic substitution, reduction, oxidation, and alkylation) starting from 4-(N,N,N-trimethylammonio)-3-cyano-3'-iodobenzophenone triflate. A remarkably high radiochemical yield (>90%) was achieved for the F-18 nucleophilic aromatic substitution under mild conditions (room temperature in less than 10 min), indicating the structural advantage of the designed molecule to facilitate the F-18 for trimethylammonium substitution in the presence of two electron-withdrawing groups (nitrile and carbonyl). The overall radiosynthesis time for compound 2 is less than 3 h after end of bombardment (EOB) with an unoptimized radiochemical yield of about 2% (not decay corrected) and specific activity of 0.8 Ci/ mu mol at EOB. The radiolabeling precursors for compound 1 and 2 were synthesized via a carbon-carbon bond-forming reaction between 2-substituted-5-lithiobenzonitrile and 3-substituted benzaldehyde derivatives. Compounds 1 and 2 should allow us to label biomolecules with F-18 or iodine isotopes and gives structurally identical products, which are expected to have identical biological properties and should be useful for comparative imaging studies. JF - Bioconjugate Chemistry AU - Li, Z AU - Ding, Y-S AU - Gifford, A AU - Fowler, J S AU - Gatley, J S AD - Medical Department and Chemistry Department, Brookhaven National Laboratory, Upton, New York 11978, USA Y1 - 2003/03// PY - 2003 DA - Mar 2003 SP - 287 EP - 294 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org], [URL:http://pubs.acs.org] VL - 14 IS - 2 SN - 1043-1802, 1043-1802 KW - benzophenone KW - comparative imaging KW - fluorine 18 KW - iodine KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18748766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Synthesis+of+Structurally+Identical+Fluorine-18+and+Iodine+Isotope+Labeling+Compounds+for+Comparative+Imaging&rft.au=Li%2C+Z%3BDing%2C+Y-S%3BGifford%2C+A%3BFowler%2C+J+S%3BGatley%2C+J+S&rft.aulast=Li&rft.aufirst=Z&rft.date=2003-03-01&rft.volume=14&rft.issue=2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc025616nS1043-1802%2802%2905616-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bc025616nS1043-1802(02)05616-1 ER - TY - JOUR T1 - A pseudo-force iterative method with separate scale factors for dynamic analysis of structures with non-proportional damping AN - 52020615; 2003-019549 AB - Dynamic equilibrium equations of structural systems with non-proportional damping are coupled through the damping terms. Such coupling invalidates application of the classical modal superposition method. In this paper, a mode-superposition pseudo-force method is proposed. The coupled equilibrium equations are solved by an iterative process in which the coupling terms are treated as pseudo-forces. A scale factor for each mode of the system is obtained by optimizing the iteration convergence. Through these uniquely solved scale factors, the modified modal equations not only converge much faster but also yield results with higher accuracy. A proof of the convergence of the iterative process is also presented. Abstract Copyright (2003), Wiley Periodicals, Inc. JF - Earthquake Engineering & Structural Dynamics AU - Lin, Feng-Bao AU - Wang, Yung-Kuo AU - Cho, Young S Y1 - 2003/02// PY - 2003 DA - February 2003 SP - 329 EP - 337 PB - Wiley & Sons, Chichester-New York VL - 32 IS - 2 SN - 0098-8847, 0098-8847 KW - scale factor KW - attenuation KW - Claret method KW - soil-structure interface KW - iterative methods KW - mathematical methods KW - equations KW - aseismic design KW - equilibrium KW - accuracy KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52020615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earthquake+Engineering+%26+Structural+Dynamics&rft.atitle=A+pseudo-force+iterative+method+with+separate+scale+factors+for+dynamic+analysis+of+structures+with+non-proportional+damping&rft.au=Lin%2C+Feng-Bao%3BWang%2C+Yung-Kuo%3BCho%2C+Young+S&rft.aulast=Lin&rft.aufirst=Feng-Bao&rft.date=2003-02-01&rft.volume=32&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Earthquake+Engineering+%26+Structural+Dynamics&rft.issn=00988847&rft_id=info:doi/10.1002%2Feqe.234 L2 - http://www3.interscience.wiley.com/journal/1922/home LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from John Wiley & Sons, Chichester, United Kingdom N1 - Date revised - 2003-01-01 N1 - Number of references - 8 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - accuracy; aseismic design; attenuation; Claret method; equations; equilibrium; iterative methods; mathematical methods; scale factor; soil-structure interface DO - http://dx.doi.org/10.1002/eqe.234 ER - TY - BOOK T1 - Tropospheric aerosols AN - 884411718; 2011-067499 JF - The atmosphere AU - Buseck, P R AU - Schwartz, S E A2 - Keeling, R. F. A2 - Holland, H. D. A2 - Turekian, K. K. Y1 - 2003 PY - 2003 DA - 2003 PB - Elsevier, Oxford SN - 0080437516 KW - pollution KW - troposphere KW - climate change KW - bibliography KW - urban environment KW - air pollution KW - spatial variations KW - optical properties KW - transport KW - rural environment KW - aerosols KW - geochemistry KW - review KW - particles KW - climate KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/884411718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Buseck%2C+P+R%3BSchwartz%2C+S+E&rft.aulast=Buseck&rft.aufirst=P&rft.date=2003-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0080437516&rft.btitle=Tropospheric+aerosols&rft.title=Tropospheric+aerosols&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 203 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Recent advances in the development and commercialization of geothermal silica products AN - 881457494; 2011-065435 AB - Systematic studies of the chemical and physical properties of geothermal silicas have shown that these properties vary to a significant extent and depend on their original source and its relative composition. However, under certain processing conditions, geothermal brines can cost-efficiently, yield a number of commercially attractive silica products. Co-production of such products can lower the cost of the overall geothermal energy production and simultaneously expands and enriches the usability of the geothermal resources. In this paper the production, economics and application of high quality silica from geothermal brines will be discussed in terms of several specific examples. JF - Transactions - Geothermal Resources Council AU - Lin, Mow S AU - Premuzic, Eugene T AU - Dong, Bin AU - Zhou, Wei M AU - Johnson, Stuart D AU - Gutierrez-Puente, Hector AU - Garg, Sabodh K Y1 - 2003 PY - 2003 DA - 2003 SP - 547 EP - 550 PB - GRC - Geothermal Resources Council, Davis, CA VL - 27 SN - 0193-5933, 0193-5933 KW - chromatography KW - markets KW - properties KW - salinity KW - byproducts KW - silicon KW - production KW - recovery KW - molecular structure KW - geothermal energy KW - geothermal fields KW - reagents KW - thin layer chromatography KW - silica KW - brines KW - nonmetal deposits KW - pilot plants KW - testing KW - economics KW - transformations KW - chemical composition KW - 26A:Economic geology, general, deposits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/881457494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Recent+advances+in+the+development+and+commercialization+of+geothermal+silica+products&rft.au=Lin%2C+Mow+S%3BPremuzic%2C+Eugene+T%3BDong%2C+Bin%3BZhou%2C+Wei+M%3BJohnson%2C+Stuart+D%3BGutierrez-Puente%2C+Hector%3BGarg%2C+Sabodh+K&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2003-01-01&rft.volume=27&rft.issue=&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal resources council, 2003 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - Number of references - 10 N1 - PubXState - CA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - brines; byproducts; chemical composition; chromatography; economics; geothermal energy; geothermal fields; markets; molecular structure; nonmetal deposits; pilot plants; production; properties; reagents; recovery; salinity; silica; silicon; testing; thin layer chromatography; transformations ER - TY - JOUR T1 - Monoamine oxidase and cigarette smoking. AN - 72999190; 12564384 AB - Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation. JF - Neurotoxicology AU - Fowler, Joanna S AU - Logan, Jean AU - Wang, Gene-Jack AU - Volkow, Nora D AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 75 EP - 82 VL - 24 IS - 1 SN - 0161-813X, 0161-813X KW - Monoamine Oxidase Inhibitors KW - 0 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Brain -- enzymology KW - Animals KW - Smoking Cessation -- psychology KW - Monoamine Oxidase Inhibitors -- metabolism KW - Humans KW - Mental Disorders -- enzymology KW - Mental Disorders -- psychology KW - Smoking -- metabolism KW - Smoking -- psychology KW - Monoamine Oxidase -- metabolism KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72999190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Monoamine+oxidase+and+cigarette+smoking.&rft.au=Fowler%2C+Joanna+S%3BLogan%2C+Jean%3BWang%2C+Gene-Jack%3BVolkow%2C+Nora+D&rft.aulast=Fowler&rft.aufirst=Joanna&rft.date=2003-01-01&rft.volume=24&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2003-02-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Synchrotron X-ray diffraction study of the structure and dehydration behavior of todorokite AN - 52013415; 2003-024310 AB - Real-time, temperature-resolved synchrotron powder X-ray diffraction data and Rietveld refinements were used to investigate the behavior of the todorokite structure from 100 to 820 K. At 298 K, the lower valence cations, such as Mn (super 3+) , occupy large octahedral sites at the edges of the triple chains, and four water/cation sites are in the tunnels. In our heating experiments in vacuum, todorokite began to break down at approximately 450 K and fully decomposed by 620 K, at which point hausmannite started to form. Our results suggest that the loss of O (sub 2) accompanied the reduction of Mn (super 4+) to Mn (super 3+) and Mn (super 2+) , and these reactions impelled a breakdown of the octahedral framework and the subsequent release of the tunnel water molecules. Rietveld refinements revealed a gradual thermal expansion of todorokite structure to approximately 450 K. At higher temperatures, the unit-cell volume gradually decreased, primarily as a result of a decrease in c, and the decline in beta with increasing temperature was accelerated. A mechanism for forming the inverse spinel hausmannite structure from todorokite is presented. JF - American Mineralogist AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan Y1 - 2003/01// PY - 2003 DA - January 2003 SP - 142 EP - 150 PB - Mineralogical Society of America, Washington, DC VL - 88 IS - 1 SN - 0003-004X, 0003-004X KW - experimental studies KW - X-ray diffraction data KW - unit cell KW - phase transitions KW - crystal structure KW - bonding KW - Rietveld refinement KW - temperature KW - todorokite KW - hausmannite KW - oxides KW - heating KW - synchrotrons KW - dehydration KW - high temperature KW - P-T conditions KW - 17A:General geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52013415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Synchrotron+X-ray+diffraction+study+of+the+structure+and+dehydration+behavior+of+todorokite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2003-01-01&rft.volume=88&rft.issue=1&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 33 N1 - PubXState - DC N1 - Document feature - illus. incl. 3 tables N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - bonding; crystal structure; dehydration; experimental studies; hausmannite; heating; high temperature; oxides; P-T conditions; phase transitions; Rietveld refinement; synchrotrons; temperature; todorokite; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Study of the microgeometry of porous materials using synchrotron computed microtomography AN - 51899625; 2004-011033 AB - A series of measurements of the structure of a variety of porous materials has been made using synchrotron computed microtomography (SCMT). The work was carried out at the Brookhaven National Synchrotron Light Source (NSLS), the Argonne Advanced Photon Source (APS) and the European Synchrotron Radiation Facility (ESRF). The experiments at Brookhaven and Argonne were carried out on bending magnet beam lines using area detectors to obtain CT images based on determination of X-ray absorption coefficients. The work at the ESRF used an undulator beam line, a 13 KeV pencil X-ray beam of 2 mu m and an energy dispersive X-ray detector to make tomographic sections of trace element distributions by X-ray fluorescence tomography. Most of the work was done with a pixel/voxel size ranging from 0.002 to 0.010 mm. We examined the structure of unconsolidated estuarine sediments, whose structure is relevant to transport of contaminants in rivers and estuaries. Fluorescent tomography with 2-3 mu m resolution was used to ascertain whether or not metals were concentrated on the surface or throughout the volume of a single sediment particle. Sandstone samples were investigated to obtain a set of values describing their microstructures that could be useful in fluid flow calculations relevant to petroleum recovery or transport of environmental contaminants. Measurements were also made on sandstone samples that had been subjected to high-pressure compression to investigate the relation between the microgeometry and the magnitude of the applied pressure. Finally, a Wood's metal-filled sample was scanned for demonstration of resolution enhancement and fluid flow studies. JF - Geological Society Special Publications AU - Jones, K W AU - Feng, H AU - Lindquist, W B AU - Adler, P M AU - Thovert, J F AU - Vekemans, B AU - Vincze, L AU - Szaloki, I AU - van Grieken, R AU - Adams, F AU - Riekel, C A2 - Mees, F. A2 - Swennen, R. A2 - van Geet, M. A2 - Jacobs, P. Y1 - 2003 PY - 2003 DA - 2003 SP - 39 EP - 49 PB - Geological Society of London, London VL - 215 SN - 0305-8719, 0305-8719 KW - United States KW - solute transport KW - New Jersey Harbor KW - chlorinated hydrocarbons KW - imagery KW - strain KW - PCBs KW - Europe KW - fluid dynamics KW - reservoir rocks KW - synchrotron radiation KW - France KW - visualization KW - laboratory studies KW - marine sediments KW - sedimentary rocks KW - sediments KW - X-ray analysis KW - halogenated hydrocarbons KW - applications KW - high-resolution methods KW - experimental studies KW - Western Europe KW - three-dimensional models KW - textures KW - pollutants KW - grain size KW - pollution KW - porous materials KW - porosity KW - geometry KW - compaction KW - case studies KW - Vosges France KW - organic compounds KW - metals KW - New Jersey KW - North Sea KW - North Atlantic KW - computed tomography data KW - Vosges Sandstone KW - instruments KW - Atlantic Ocean KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51899625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geological+Society+Special+Publications&rft.atitle=Study+of+the+microgeometry+of+porous+materials+using+synchrotron+computed+microtomography&rft.au=Jones%2C+K+W%3BFeng%2C+H%3BLindquist%2C+W+B%3BAdler%2C+P+M%3BThovert%2C+J+F%3BVekemans%2C+B%3BVincze%2C+L%3BSzaloki%2C+I%3Bvan+Grieken%2C+R%3BAdams%2C+F%3BRiekel%2C+C&rft.aulast=Jones&rft.aufirst=K&rft.date=2003-01-01&rft.volume=215&rft.issue=&rft.spage=39&rft.isbn=1862391394&rft.btitle=&rft.title=Geological+Society+Special+Publications&rft.issn=03058719&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 23 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GSLSBW N1 - SubjectsTermNotLitGenreText - applications; Atlantic Ocean; case studies; chlorinated hydrocarbons; compaction; computed tomography data; Europe; experimental studies; fluid dynamics; France; geometry; grain size; halogenated hydrocarbons; high-resolution methods; imagery; instruments; laboratory studies; marine sediments; metals; New Jersey; New Jersey Harbor; North Atlantic; North Sea; organic compounds; PCBs; pollutants; pollution; porosity; porous materials; reservoir rocks; sedimentary rocks; sediments; solute transport; strain; synchrotron radiation; textures; three-dimensional models; United States; visualization; Vosges France; Vosges Sandstone; Western Europe; X-ray analysis ER - TY - JOUR T1 - The use of alternative techniques for remediation of polluted sites and groundwater in Flanders; plant-based strategies AN - 51837518; 2004-045727 JF - Journal of Soils and Sediments AU - Vangronsveld, Jaco AU - van der Lelie, Daniel Y1 - 2003 PY - 2003 DA - 2003 SP - 250 EP - 251 PB - Ecomed Publishers, Landsberg VL - 3 IS - 4 SN - 1439-0108, 1439-0108 KW - soils KW - water quality KW - Western Europe KW - pollutants KW - pollution KW - Europe KW - bioremediation KW - Flanders Belgium KW - remediation KW - ground water KW - aquifers KW - Belgium KW - phytoremediation KW - discharge KW - smelting KW - heavy metals KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51837518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=The+use+of+alternative+techniques+for+remediation+of+polluted+sites+and+groundwater+in+Flanders%3B+plant-based+strategies&rft.au=Vangronsveld%2C+Jaco%3Bvan+der+Lelie%2C+Daniel&rft.aulast=Vangronsveld&rft.aufirst=Jaco&rft.date=2003-01-01&rft.volume=3&rft.issue=4&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 4 N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aquifers; Belgium; bioremediation; discharge; Europe; Flanders Belgium; ground water; heavy metals; microorganisms; phytoremediation; pollutants; pollution; remediation; smelting; soils; water quality; Western Europe ER - TY - JOUR T1 - Arsenic XAFS spectroscopy as a monitor for controlled pyrite oxidation in selected bituminous coal samples AN - 51580746; 2006-046404 JF - Programme & Abstracts - International Symposium on Environmental Geochemistry (ISEG) AU - Kolker, A AU - Huggins, F AU - Khalid, S AU - Farmer, John G Y1 - 2003 PY - 2003 DA - 2003 SP - 86 PB - [varies], [varies] VL - 6 KW - qualitative analysis KW - bituminous coal KW - sedimentary rocks KW - coal KW - X-ray analysis KW - applications KW - toxic materials KW - experimental studies KW - chemical analysis KW - monitoring KW - acid mine drainage KW - pollutants KW - oxidation KW - arsenic KW - pollution KW - weathering KW - sample preparation KW - metals KW - XANES KW - X-ray spectroscopy KW - pyrite KW - XAFS KW - sulfides KW - spectroscopy KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51580746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Programme+%26+Abstracts+-+International+Symposium+on+Environmental+Geochemistry+%28ISEG%29&rft.atitle=Arsenic+XAFS+spectroscopy+as+a+monitor+for+controlled+pyrite+oxidation+in+selected+bituminous+coal+samples&rft.au=Kolker%2C+A%3BHuggins%2C+F%3BKhalid%2C+S%3BFarmer%2C+John+G&rft.aulast=Kolker&rft.aufirst=A&rft.date=2003-01-01&rft.volume=6&rft.issue=&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Programme+%26+Abstracts+-+International+Symposium+on+Environmental+Geochemistry+%28ISEG%29&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 6th international symposium on Environmental geochemistry N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 1 N1 - Last updated - 2012-06-07 N1 - CODEN - #06649 N1 - SubjectsTermNotLitGenreText - acid mine drainage; applications; arsenic; bituminous coal; chemical analysis; coal; experimental studies; metals; monitoring; oxidation; pollutants; pollution; pyrite; qualitative analysis; sample preparation; sedimentary rocks; spectroscopy; sulfides; toxic materials; weathering; X-ray analysis; X-ray spectroscopy; XAFS; XANES ER - TY - JOUR T1 - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space AN - 51481651; 2007-022861 JF - Advances in Space Research A2 - Horneck, G. A2 - Vasquez, M. E. A2 - Porterfield, D. M. Y1 - 2003 PY - 2003 DA - 2003 SP - 272 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - planets KW - Plantae KW - symposia KW - planetology KW - astrobiology KW - Mars KW - research KW - life support systems KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51481651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Advances+in+Space+Research&rft.atitle=Thirty-third+COSPAR+scientific+assembly+on+Space+life+sciences%3B+missions+to+Mars%2C+radiation+biology%2C+and+plants+as+a+foundation+for+long-term+life+support+systems+in+space&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Document feature - illus. incl. tables N1 - SuppNotes - Individual papers within scope are cited separately N1 - Last updated - 2012-06-07 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - astrobiology; life support systems; Mars; planetology; planets; Plantae; research; symposia; terrestrial planets ER - TY - JOUR T1 - Sterilisation properties of the Mars surface and atmospheric environment AN - 51481281; 2007-022862 JF - Advances in Space Research AU - Moreau, Didier AU - Muller, Christian Y1 - 2003 PY - 2003 DA - 2003 SP - 97 EP - 102 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - models KW - surface properties KW - sterilization KW - planets KW - photochemistry KW - atmosphere KW - Mars KW - properties KW - geochemistry KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51481281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Sterilisation+properties+of+the+Mars+surface+and+atmospheric+environment&rft.au=Moreau%2C+Didier%3BMuller%2C+Christian&rft.aulast=Moreau&rft.aufirst=Didier&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 6 N1 - Document feature - illus. N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - atmosphere; exploration; geochemistry; Mars; models; photochemistry; planets; properties; sterilization; surface properties; terrestrial planets ER - TY - JOUR T1 - Biochemical treatment of produced water AN - 51437590; 2007-053968 JF - Abstracts - AAPG Mid-Continent Section Meeting AU - Lin, Mow AU - Anonymous Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - American Association of Petroleum Geologists, Mid-Continent Section, Tulsa, OK VL - 2003 KW - water KW - oil wells KW - biodegradation KW - fluid injection KW - pollutants KW - water treatment KW - purification KW - pollution KW - crude oil KW - water pollution KW - heavy metals KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51437590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+-+AAPG+Mid-Continent+Section+Meeting&rft.atitle=Biochemical+treatment+of+produced+water&rft.au=Lin%2C+Mow%3BAnonymous&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2003-01-01&rft.volume=2003&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Abstracts+-+AAPG+Mid-Continent+Section+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.searchanddiscovery.net/abstracts/pdf/2003/midcon/abs/ndx_lin.pdf LA - English DB - GeoRef N1 - Conference title - AAPG Mid-Continent Section meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - OK N1 - SuppNotes - Accessed on Aug. 25, 2006 N1 - Last updated - 2012-06-07 N1 - CODEN - #06711 N1 - SubjectsTermNotLitGenreText - biodegradation; crude oil; fluid injection; heavy metals; oil wells; pollutants; pollution; purification; water; water pollution; water treatment ER - TY - JOUR T1 - Synchrotron-based mu XRD and mu XANES on arsenic-bearing mine waste from Yellowknife AN - 51436822; 2007-053719 JF - Program with Abstracts - Geological Association of Canada; Mineralogical Association of Canada: Joint Annual Meeting AU - Walker, S R AU - Andrade, C F AU - Jamieson, H E AU - Lanzirotti, A AU - Anonymous Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - Geological Association of Canada, Waterloo, ON VL - 28 SN - 0701-8738, 0701-8738 KW - mines KW - experimental studies KW - chemical analysis KW - mine waste KW - X-ray diffraction data KW - waste rock KW - pollutants KW - arsenic KW - pollution KW - X-ray spectra KW - Northwest Territories KW - XANES spectra KW - synchrotron radiation KW - laboratory studies KW - Canada KW - Yellowknife Northwest Territories KW - metals KW - Western Canada KW - spectra KW - geochemistry KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51436822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.atitle=Synchrotron-based+mu+XRD+and+mu+XANES+on+arsenic-bearing+mine+waste+from+Yellowknife&rft.au=Walker%2C+S+R%3BAndrade%2C+C+F%3BJamieson%2C+H+E%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Walker&rft.aufirst=S&rft.date=2003-01-01&rft.volume=28&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.issn=07018738&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Association of Canada, Mineralogical Association of Canada; joint annual meeting--Association geologique du Canada, Association mineralogique du Canada; congres annuel conjoint N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - PubXState - ON N1 - SuppNotes - All meeting abstracts available at http://gac.esd.mun.ca/gac_2003/search_abs/program.htm N1 - Last updated - 2012-06-07 N1 - CODEN - PAACD6 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; chemical analysis; experimental studies; geochemistry; laboratory studies; metals; mine waste; mines; Northwest Territories; pollutants; pollution; spectra; synchrotron radiation; waste rock; Western Canada; X-ray diffraction data; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Comments from the point of view of chemical evolution and origins of life AN - 50252685; 2007-022864 JF - Advances in Space Research AU - Kobayashi, K Y1 - 2003 PY - 2003 DA - 2003 SP - 109 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - terrestrial planets KW - planets KW - organic compounds KW - Earth KW - biochemistry KW - planetology KW - Mars KW - concepts KW - life origin KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50252685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Comments+from+the+point+of+view+of+chemical+evolution+and+origins+of+life&rft.au=Kobayashi%2C+K&rft.aulast=Kobayashi&rft.aufirst=K&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 2 N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - biochemistry; concepts; Earth; exploration; life origin; Mars; organic compounds; planetology; planets; terrestrial planets ER - TY - JOUR T1 - Planetary protection and the search for life beneath the surface of Mars AN - 50248891; 2007-022863 JF - Advances in Space Research AU - Mancinelli, Rocco L Y1 - 2003 PY - 2003 DA - 2003 SP - 103 EP - 107 PB - Elsevier, Oxford-New York VL - 31 IS - 1 SN - 0273-1177, 0273-1177 KW - water KW - terrestrial planets KW - protection KW - surface properties KW - planets KW - sampling KW - planetology KW - Mars KW - life origin KW - exploration KW - 04:Extraterrestrial geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50248891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+Space+Research&rft.atitle=Planetary+protection+and+the+search+for+life+beneath+the+surface+of+Mars&rft.au=Mancinelli%2C+Rocco+L&rft.aulast=Mancinelli&rft.aufirst=Rocco&rft.date=2003-01-01&rft.volume=31&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Advances+in+Space+Research&rft.issn=02731177&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/02731177 LA - English DB - GeoRef N1 - Conference title - Thirty-third COSPAR scientific assembly on Space life sciences; missions to Mars, radiation biology, and plants as a foundation for long-term life support systems in space N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 13 N1 - Last updated - 2014-09-18 N1 - CODEN - ASRSDW N1 - SubjectsTermNotLitGenreText - exploration; life origin; Mars; planetology; planets; protection; sampling; surface properties; terrestrial planets; water ER - TY - JOUR T1 - The Application of Molecular Tools to Follow up Bioremediation AN - 19428772; 5915862 AB - During the last decades, major advances have been made in understanding the mechanisms of interactions between microorganisms and pollutants, and in the application of specialized microorganisms for the in situ and ex situ treatment of organic xenobiotics, heavy metal and radionuclide contaminated soils, wastes and groundwater. The efficiency of bioremediation depends on the presence and activities of the microorganisms involved which is, in turn, affected by environmental conditions, operational parameters and the local composition of the overall microbial community composition. Hence, when opting for a biological remediation strategy, important questions to be answered as part of the overall remediation strategy include: (i) are microorganisms with the desired characteristics and activities present at the contaminated site and at what densities, (ii) what is their activity, (iii) and how is the microbial community composition and functioning influenced by environmental parameters and process conditions? Recently, molecular and non-molecular methods for the identification and characterization of bacteria and their specific properties have been used to assess the composition and activity of microbial communities found at contaminated sites or in the rhizosphere of plants. For the future, these techniques contain the promise to be applied as complementary tools to classical chemical and physiological analytical methods (pollutant concentrations and speciation, redox potential, etc.) to monitor the spatial and temporary changes in microbial community composition and functioning during bioremediation processes. JF - Journal of Soils and Sediments AU - Geets, J AU - Vangronsveld, J AU - Diels, L AU - van der Lelie, D AD - Brookhaven National Laboratory, Biology Department, Building 463, Upton, NY11973-5000, USA, vdlelied@bnl.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 251 VL - 3 IS - 4 SN - 1439-0108, 1439-0108 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Pollution Abstracts KW - Bioremediation KW - Heavy metals KW - Rhizosphere KW - Wastes KW - Xenobiotics KW - Sediments KW - Soil microorganisms KW - Soil pollution KW - Community composition KW - Pollutants KW - Plant communities KW - Microorganisms KW - Ground water KW - Radioisotopes KW - Environmental conditions KW - Redox potential KW - A 01340:Antibiotics & Antimicrobials KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19428772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=The+Application+of+Molecular+Tools+to+Follow+up+Bioremediation&rft.au=Geets%2C+J%3BVangronsveld%2C+J%3BDiels%2C+L%3Bvan+der+Lelie%2C+D&rft.aulast=Geets&rft.aufirst=J&rft.date=2003-01-01&rft.volume=3&rft.issue=4&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2004-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Bioremediation; Heavy metals; Rhizosphere; Wastes; Xenobiotics; Sediments; Soil pollution; Community composition; Pollutants; Radioisotopes; Ground water; Microorganisms; Plant communities; Environmental conditions; Redox potential; Soil microorganisms ER - TY - JOUR T1 - Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape AN - 19219899; 5764632 AB - Contrast reagents (CRs) may enter the tissue interstitium for a period after a vascular bolus injection. As the amount of interstitial CR increases, the longitudinal relaxographic NMR "shutter-speed" (T super(-1)) for the equilibrium transcytolemmal water exchange process increases. The quantity T super(-1) is given by |r sub(1o)[CR sub(o)] + R sub(1o0)-R sub(1i)| (where r sub(1o) and [CR sub(o)] represent the interstitial (extracellular) CR relaxivity and concentration, respectively, and R sub(1o0) and R sub(1i) are the extra- and intracellular super(1)H sub(2)O relaxation rate constants, respectively, in the absence of exchange). The increase of T super(-1) with [CR sub(o)] causes the kinetics of the water exchange equilibrium to appear to decrease. Here, analytical theory for two-site-exchange processes is combined with that for pharmacokinetic CR delivery, extraction, and distribution in a method termed BOLus Enhanced Relaxation Overview (BOLERO super()). The shutter-speed effect alters the shape of the bolus-tracking (B-T) time- course. It is shown that this is mostly accounted for by the inclusion of only one additional parameter, which measures the mean intracellular lifetime of a water molecule. Simulated and real data demonstrate that the effect of shutter- speed variation on pharmacokinetic parameters can be very significant: neglecting this effect can lead to an underestimation of the parameter values by 50%. This phenomenon can be heterogeneous. Within a tiny gliosarcoma implanted in the rat brain, the interstitial CR in the tumor core never rises to a level sufficient to cause apparent slowing of the exchange process. However, within the few microns needed to reach the proliferating rim, this occurs to a significant degree. Thus, even relative pharmacokinetic quantities can be incorrectly represented in a parametric map that neglects this effect. The BOLERO analysis shows promise for in vivo vascular phenotyping in pathophysiology. It also includes a provision for approximating the separation of the perfusion and permeability contributions to CR extravasation. JF - Magnetic Resonance in Medicine AU - Yankeelov, TE AU - Rooney, W D AU - Li, X AU - Springer, CS Jr AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York, springer@ohsu.edu Y1 - 2003 PY - 2003 DA - 2003 SP - 1151 EP - 1169 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 50 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Water exchange KW - Pathophysiology KW - Relaxation KW - Magnetic resonance imaging KW - N.M.R. KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19219899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Variation+of+the+relaxographic+%22shutter-speed%22+for+transcytolemmal+water+exchange+affects+the+CR+bolus-tracking+curve+shape&rft.au=Yankeelov%2C+TE%3BRooney%2C+W+D%3BLi%2C+X%3BSpringer%2C+CS+Jr&rft.aulast=Yankeelov&rft.aufirst=TE&rft.date=2003-01-01&rft.volume=50&rft.issue=6&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.10624 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - N.M.R.; Magnetic resonance imaging; Water exchange; Relaxation; Pathophysiology DO - http://dx.doi.org/10.1002/mrm.10624 ER - TY - JOUR T1 - Echo planar imaging at 4 tesla with minimum acoustic noise AN - 18939802; 5685118 AB - To minimize the acoustic sound pressure levels of single-shot echo planar imaging (EPI) acquisitions on high magnetic field MRI scanners. The resonance frequencies of gradient coil vibrations, which depend on the coil length and the elastic properties of the materials in the coil assembly, were measured using piezoelectric transducers. The frequency of the EPI-readout train was adjusted to avoid the frequency ranges of mechanical resonances. Our MRI system exhibited two sharp mechanical resonances (at 720 and 1220 Hz) that can increase vibrational amplitudes up to six-fold. A small adjustment of the EPI-readout frequency made it possible to reduce the sound pressure level of EPI-based perfusion and functional MRI scans by 12 dB. Normal vibrational modes of MRI gradient coils can dramatically increase the sound pressure levels during echo planar imaging (EPI) scans. To minimize acoustic noise, the frequency of EPI- readout trains and the resonance frequencies of gradient coil vibrations need to be different. JF - Journal of Magnetic Resonance Imaging AU - Tomasi, D G AU - Ernst, T AD - Medical Department, Bldg 490, Brookhaven National Laboratory, 30 Bell Ave. Upton, NY, 11973, Tomasi@bnl.gov Y1 - 2003 PY - 2003 DA - 2003 SP - 128 EP - 130 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 18 IS - 1 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Vibrations KW - Piezoelectricity KW - Acoustics KW - Magnetic resonance imaging KW - Noise KW - Mechanical properties KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18939802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Echo+planar+imaging+at+4+tesla+with+minimum+acoustic+noise&rft.au=Tomasi%2C+D+G%3BErnst%2C+T&rft.aulast=Tomasi&rft.aufirst=D&rft.date=2003-01-01&rft.volume=18&rft.issue=1&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.10326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Noise; Acoustics; Mechanical properties; Piezoelectricity; Vibrations DO - http://dx.doi.org/10.1002/jmri.10326 ER - TY - JOUR T1 - Microanalysis of NY/NJ Harbor sediments using synchrotron X-ray beams AN - 1429845274; 2013-069649 JF - Proceedings - International Conference on Remediation of Contaminated Sediments AU - Jones, K W AU - Feng, H AU - Lanzirotti, A AU - Marinkovic, N AU - Neuhaeusler, U AU - Riekel, C AU - Vincze, L AU - Vekemans, B AU - Szaloki, I AU - Song, Z Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - [varies], [varies] VL - 2 KW - United States KW - pollutants KW - harbors KW - pollution KW - techniques KW - New York/New Jersey Harbor KW - infrared spectra KW - synchrotron radiation KW - FTIR spectra KW - New York KW - detection KW - transport KW - sediments KW - ecology KW - spectra KW - particulate materials KW - New Jersey KW - depositional environment KW - estuarine environment KW - chemical composition KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429845274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.atitle=Microanalysis+of+NY%2FNJ+Harbor+sediments+using+synchrotron+X-ray+beams&rft.au=Jones%2C+K+W%3BFeng%2C+H%3BLanzirotti%2C+A%3BMarinkovic%2C+N%3BNeuhaeusler%2C+U%3BRiekel%2C+C%3BVincze%2C+L%3BVekemans%2C+B%3BSzaloki%2C+I%3BSong%2C+Z&rft.aulast=Jones&rft.aufirst=K&rft.date=2003-01-01&rft.volume=2&rft.issue=&rft.spage=&rft.isbn=1574771434&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second international conference on Remediation of contaminated sediments N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 4 N1 - Document feature - illus. N1 - Last updated - 2013-09-05 N1 - CODEN - #06496 N1 - SubjectsTermNotLitGenreText - chemical composition; depositional environment; detection; ecology; estuarine environment; FTIR spectra; harbors; infrared spectra; New Jersey; New York; New York/New Jersey Harbor; particulate materials; pollutants; pollution; sediments; spectra; synchrotron radiation; techniques; transport; United States ER - TY - JOUR T1 - Natural attenuation for ecosystem restoration in the NY/NJ Harbor AN - 1429844655; 2013-069676 JF - Proceedings - International Conference on Remediation of Contaminated Sediments AU - van der Lelie, D AU - Jones, K W AU - Reid-Green, J D AU - Stern, E A Y1 - 2003 PY - 2003 DA - 2003 EP - unpaginated PB - [varies], [varies] VL - 2 KW - United States KW - reclamation KW - ecosystems KW - bioavailability KW - Passaic River KW - toxicity KW - sediments KW - natural attenuation KW - Gowanus Canal KW - heavy metals KW - soils KW - toxic materials KW - Newtown Creek KW - Newark Bay KW - harbors KW - pollution KW - New York/New Jersey Harbor KW - measurement KW - New York KW - detection KW - bacteria KW - New Jersey KW - Hudson River KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1429844655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.atitle=Natural+attenuation+for+ecosystem+restoration+in+the+NY%2FNJ+Harbor&rft.au=van+der+Lelie%2C+D%3BJones%2C+K+W%3BReid-Green%2C+J+D%3BStern%2C+E+A&rft.aulast=van+der+Lelie&rft.aufirst=D&rft.date=2003-01-01&rft.volume=2&rft.issue=&rft.spage=&rft.isbn=1574771434&rft.btitle=&rft.title=Proceedings+-+International+Conference+on+Remediation+of+Contaminated+Sediments&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Second international conference on Remediation of contaminated sediments N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. N1 - Date revised - 2013-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2013-09-05 N1 - CODEN - #06496 N1 - SubjectsTermNotLitGenreText - bacteria; bioavailability; detection; ecosystems; Gowanus Canal; harbors; heavy metals; Hudson River; measurement; microorganisms; natural attenuation; New Jersey; New York; New York/New Jersey Harbor; Newark Bay; Newtown Creek; Passaic River; pollution; reclamation; sediments; soils; toxic materials; toxicity; United States ER - TY - JOUR T1 - Effects of alcohol detoxification on dopamine D2 receptors in alcoholics: a preliminary study. AN - 72767859; 12477600 AB - Imaging studies in patients with Type II alcohol dependence have revealed significant reductions in dopamine (DA) D2 receptor availability. Here we assessed the effects of alcohol detoxification in DA D2 receptors in alcoholic subjects. We evaluated 14 patients with Type II alcohol dependence tested within 6 weeks of detoxification and then re-tested 1-4 months later while alcohol free. The comparison group comprised 11 healthy controls. PET was used with [11C]raclopride to measure DA D2 receptors. Eight alcoholics and all control subjects were tested with a CTI 931 PET scanner and six alcoholics with a Siemens HR+ PET scanner. Data were analyzed separately for the studies done in the different scanners. Comparisons between early and late alcohol detoxification showed no significant changes in DA D2 receptor availability (B(max)/K(d)) for the studies done with the CTI and the HR+ scanners. Comparison with controls showed lower DA D2 receptor levels in caudate and putamen in alcoholics tested during early detoxification and in caudate during late detoxification. These studies replicate previous findings of lower striatal DA D2 receptors in alcoholics than in controls and absence of significant recovery during alcohol detoxification. These findings suggest that low DA D2 receptor availability in alcoholics is not due to alcohol withdrawal and may reflect a predisposing factor. JF - Psychiatry research AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Maynard, Larry AU - Fowler, Joanna S AU - Jayne, Budd AU - Telang, Frank AU - Logan, Jean AU - Ding, Yu-Shin AU - Gatley, Samuel J AU - Hitzemann, Robert AU - Wong, Christopher AU - Pappas, Naome AD - Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2002/12/30/ PY - 2002 DA - 2002 Dec 30 SP - 163 EP - 172 VL - 116 IS - 3 SN - 0165-1781, 0165-1781 KW - Dopamine Antagonists KW - 0 KW - Receptors, Dopamine D2 KW - Raclopride KW - 430K3SOZ7G KW - Index Medicus KW - Humans KW - Adult KW - Tomography, Emission-Computed KW - Brain -- metabolism KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Inactivation, Metabolic -- physiology KW - Dopamine Antagonists -- pharmacokinetics KW - Raclopride -- pharmacokinetics KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72767859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Effects+of+alcohol+detoxification+on+dopamine+D2+receptors+in+alcoholics%3A+a+preliminary+study.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMaynard%2C+Larry%3BFowler%2C+Joanna+S%3BJayne%2C+Budd%3BTelang%2C+Frank%3BLogan%2C+Jean%3BDing%2C+Yu-Shin%3BGatley%2C+Samuel+J%3BHitzemann%2C+Robert%3BWong%2C+Christopher%3BPappas%2C+Naome&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-12-30&rft.volume=116&rft.issue=3&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-01 N1 - Date created - 2002-12-12 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Ozone production efficiency in an urban area AN - 18725193; 5606927 AB - Ozone production efficiency can be defined as the number of molecules of oxidant (O sub(3) + NO sub(2)) produced photochemically when a molecule of NO sub(x) (NO + NO sub(2)) is oxidized. It conveys information about the conditions under which O sub(3) is formed and is an important parameter to consider when evaluating impacts from NO sub(x) emission sources. We present calculational and observational results on ozone production efficiency based on measurements made from aircraft flights in the Phoenix metropolitan area in May and June of 1998. Constrained steady state box model calculations are used to relate a ratio of O sub(3) production rate to NO sub(x) consumption rate (i.e., P(O sub(3))/P(NO sub(z))) to a VOC to NO sub(2) ratio of OH reactivity. Lagrangian calculations show how this ratio generally increases with time due to oxidation chemistry and plume dilution. City to city differences in ozone production efficiency can be attributed to corresponding differences in VOC to NO sub(2) reactivity ratio which in turn reflect emission patterns. Ozone production efficiencies derived from aircraft measurements in 20 plumes show a dependence on NO sub(x) concentration similar to that calculated for P(O sub(3))/P(NO sub(z)). Calculations are based on data from a single location but are believed to be applicable to a wide range of plumes from different areas. JF - Journal of Geophysical Research. D. Atmospheres AU - Kleinman, LI AU - Daum, PH AU - Lee, Y-N AU - Nunnermacker, L J AU - Springston AU - Weinstein-Lloyd, J AU - Rudolph, J AD - Atmospheric Sciences Division, Brookhaven National Laboratory, Upton, New York, USA Y1 - 2002/12/16/ PY - 2002 DA - 2002 Dec 16 PB - American Geophysical Union, 2000 Florida Ave., N.W. Washington DC 20009 USA, [mailto:service@agu.org], [URL:http://www.agu.org] VL - 107 IS - D23 SN - 0148-0227, 0148-0227 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - M2 551.510.43:Photochemical Processes (551.510.43) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18725193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.atitle=Ozone+production+efficiency+in+an+urban+area&rft.au=Kleinman%2C+LI%3BDaum%2C+PH%3BLee%2C+Y-N%3BNunnermacker%2C+L+J%3BSpringston%3BWeinstein-Lloyd%2C+J%3BRudolph%2C+J&rft.aulast=Kleinman&rft.aufirst=LI&rft.date=2002-12-16&rft.volume=107&rft.issue=D23&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research.+D.+Atmospheres&rft.issn=01480227&rft_id=info:doi/10.1029%2F2002JD002529 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1029/2002JD002529 ER - TY - JOUR T1 - A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen-binding MSCRAMM, clumping factorA AN - 18634712; 5529181 AB - We report here the crystal structure of the minimal ligand-binding segment of the Staphylococcus aureus MSCRAMM, clumping factorA. This fibrinogen- binding segment contains two similarly folded domains. The fold observed is a new variant of the immunoglobulin motif that we have called DE-variant or the DEv-IgG fold. This subgroup includes the ligand-binding domain of the collagen- binding S.aureus MSCRAMM CNA, and many other structures previously classified as jelly rolls. Structure predictions suggest that the four fibrinogen-binding S.aureus MSCRAMMs identified so far would also contain the same DEv-IgG fold. A systematic docking search using the C-terminal region of the fibrinogen [gamma]-chain as a probe suggested that a hydrophobic pocket formed between the two DEv-IgG domains of the clumping factor as the ligand- binding site. Mutagenic substitution of residues Tyr256, Pro336, Tyr338 and Lys389 in the clumping factor, which are proposed to contact the terminal residues super(408)AGDV super(411) of the [gamma]-chain, resulted in proteins with no or markedly reduced affinity for fibrinogen. JF - EMBO Journal AU - Deivanayagam, CCS AU - Wann, E R AU - Chen, W AU - Carson, M AU - Rajashankar, K R AU - Hoeoek, M AU - Narayana, SVL AD - Center for Biophysical Sciences and Engineering, School of Optometry, 244 CBSE, 1025 18th Street South, University of Alabama at Birmingham, Birmingham, AL 35294-0005, Institute of Biosciences and Technology, Center for Extracellular Matrix Biology, 2121 West Holcombe Boulevard, Texas A&M University System Health Science Center, Houston, TX 77030-303 and Brookhaven National Laboratory, Building 725A-X9, Upton, NY 119773, USA, narayana@uab.edu Y1 - 2002/12/16/ PY - 2002 DA - 2002 Dec 16 SP - 6660 EP - 6672 VL - 21 IS - 24 SN - 0261-4189, 0261-4189 KW - Microbiology Abstracts B: Bacteriology KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18634712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=A+novel+variant+of+the+immunoglobulin+fold+in+surface+adhesins+of+Staphylococcus+aureus%3A+crystal+structure+of+the+fibrinogen-binding+MSCRAMM%2C+clumping+factorA&rft.au=Deivanayagam%2C+CCS%3BWann%2C+E+R%3BChen%2C+W%3BCarson%2C+M%3BRajashankar%2C+K+R%3BHoeoek%2C+M%3BNarayana%2C+SVL&rft.aulast=Deivanayagam&rft.aufirst=CCS&rft.date=2002-12-16&rft.volume=21&rft.issue=24&rft.spage=6660&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The orbitofrontal cortex in methamphetamine addiction: involvement in fear. AN - 72776964; 12488806 AB - We used Tellegen's Multidimensional Personality Questionnaire (MPQ) harm avoidance (fear) scale and the constraint superfactor as personality measures of inhibitory control and examined their association with glucose metabolism in the orbitofrontal gyrus at rest in 14 recently abstinent methamphetamine-dependent subjects and 22 comparison subjects. Higher MPQ scores were associated with higher relative orbitofrontal gyrus metabolism in the methamphetamine-dependent subjects. There was a tendency towards a negative association for the comparison subjects (test of coincidence of regression lines for the two subject groups: F = 3.3, df = 2,32; = 0.051). These results suggest that the role of the orbitofrontal cortex in inhibitory control can be manifested in stable personality predispositions and further implicate this region in the core characteristics of drug addiction. JF - Neuroreport AU - Goldstein, Rita Z AU - Volkow, Nora D AU - Chang, Linda AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Depue, Richard A AU - Gur, Ruben C AD - Department of Human Development, Laboratory of Neurobiology of Personality and Emotion, Cornell University, Ithaca, NY 14853, USA. rgoldstein@bnl.gov Y1 - 2002/12/03/ PY - 2002 DA - 2002 Dec 03 SP - 2253 EP - 2257 VL - 13 IS - 17 SN - 0959-4965, 0959-4965 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methamphetamine KW - 44RAL3456C KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Self-Injurious Behavior -- diagnostic imaging KW - Self-Injurious Behavior -- physiopathology KW - Age Factors KW - Avoidance Learning -- physiology KW - Sex Characteristics KW - Humans KW - Avoidance Learning -- drug effects KW - Self-Injurious Behavior -- metabolism KW - Brain Mapping KW - Exploratory Behavior -- drug effects KW - Adult KW - Tomography, Emission-Computed KW - Exploratory Behavior -- physiology KW - Middle Aged KW - Neuropsychological Tests KW - Female KW - Male KW - Prefrontal Cortex -- diagnostic imaging KW - Amphetamine-Related Disorders -- metabolism KW - Prefrontal Cortex -- metabolism KW - Energy Metabolism -- physiology KW - Glucose -- metabolism KW - Prefrontal Cortex -- physiopathology KW - Fear -- psychology KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Fear -- drug effects KW - Amphetamine-Related Disorders -- physiopathology KW - Energy Metabolism -- drug effects KW - Methamphetamine -- pharmacology KW - Fear -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72776964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroreport&rft.atitle=The+orbitofrontal+cortex+in+methamphetamine+addiction%3A+involvement+in+fear.&rft.au=Goldstein%2C+Rita+Z%3BVolkow%2C+Nora+D%3BChang%2C+Linda%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BDepue%2C+Richard+A%3BGur%2C+Ruben+C&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2002-12-03&rft.volume=13&rft.issue=17&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Neuroreport&rft.issn=09594965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-04-15 N1 - Date created - 2002-12-18 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: J Cereb Blood Flow Metab. 1986 Aug;6(4):441-6 [3488322] Radiology. 1993 Jan;186(1):59-65 [8416587] Synapse. 1993 Jun;14(2):169-77 [8101394] J Pharmacol Exp Ther. 1985 Dec;235(3):677-82 [4078729] Am J Psychiatry. 2002 Oct;159(10):1642-52 [12359667] Neurosci Lett. 2002 Aug 16;328(3):233-6 [12147314] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2450-4 [11842195] J Neurol Neurosurg Psychiatry. 1994 Dec;57(12):1518-24 [7798983] Rev Neurol (Paris). 1986;142(11):851-5 [2881340] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] J Addict Dis. 1996;15(4):55-71 [8943582] Br J Psychiatry Suppl. 1998;(35):26-37 [9829024] Am J Psychiatry. 1999 Mar;156(3):470-3 [10080567] Neuroreport. 2001 Aug 8;12(11):2595-9 [11496155] Behav Brain Sci. 1999 Jun;22(3):491-517; discussion 518-69 [11301519] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Clustered DNA damages induced in human hematopoietic cells by low doses of ionizing radiation. AN - 72901993; 12793749 AB - Ionizing radiation induces clusters of DNA damages--oxidized bases, abasic sites and strand breaks--on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human cells, DSB are about 30% of the total of complex damages, and the levels of DSBs and oxidized pyrimidine clusters are similar. The dose responses for cluster induction in cells can be described by a linear relationship, implying that even low doses of ionizing radiation can produce clustered damages. Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation. JF - Journal of radiation research AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Cintron-Torres, Nela AU - Hada, Megumi AU - Trunk, John AU - Monteleone, Denise AU - Sutherland, John C AU - Laval, Jacques AU - Stanislaus, Marisha AU - Gewirtz, Alan AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. bms@bnl.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - S149 EP - S152 VL - 43 Suppl SN - 0449-3060, 0449-3060 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - Humans KW - Dose-Response Relationship, Radiation KW - DNA -- radiation effects KW - Linear Energy Transfer KW - Cell Line KW - Multigene Family -- radiation effects KW - Monocytes -- physiology KW - DNA Damage KW - Monocytes -- radiation effects KW - Hematopoiesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72901993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+radiation+research&rft.atitle=Clustered+DNA+damages+induced+in+human+hematopoietic+cells+by+low+doses+of+ionizing+radiation.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BCintron-Torres%2C+Nela%3BHada%2C+Megumi%3BTrunk%2C+John%3BMonteleone%2C+Denise%3BSutherland%2C+John+C%3BLaval%2C+Jacques%3BStanislaus%2C+Marisha%3BGewirtz%2C+Alan&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2002-12-01&rft.volume=43+Suppl&rft.issue=&rft.spage=S149&rft.isbn=&rft.btitle=&rft.title=Journal+of+radiation+research&rft.issn=04493060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-07-15 N1 - Date created - 2003-06-09 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies. AN - 72745935; 12468018 AB - Methylphenidate is the most commonly prescribed drug for the treatment of ADHD. We have used positron emission tomography to assess the role that methylphenidate's effects in brain dopamine have on its therapeutic and reinforcing effects. We have documented that in the human brain therapeutic doses of methylphenidate block more than 50% of the dopamine transporters and significantly enhance extracellular DA, an effect that appears to be modulated by the rate of DA release. Thus, we postulate that methylphenidate's therapeutic effects are in part due to amplification of DA signals, that variability in responses is in part due to differences in DA tone and that methylphenidate's effects are context dependent. Methylphenidate-induced increases in DA are also associated with its reinforcing effects but only when this occurs rapidly, as with intravenous administration. Moreover, abuse of methylphenidate is constrained by its long half-life, which we postulate limits the frequency at which it can be administered. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene Jack AU - Ding, Yu Shin AU - Gatley, Samuel J AD - Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2002/12// PY - 2002 DA - December 2002 SP - 557 EP - 566 VL - 12 IS - 6 SN - 0924-977X, 0924-977X KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Dopamine Uptake Inhibitors KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Animals KW - Humans KW - Tomography, Emission-Computed KW - Attention Deficit Disorder with Hyperactivity -- diagnostic imaging KW - Substance-Related Disorders -- metabolism KW - Attention Deficit Disorder with Hyperactivity -- metabolism KW - Substance-Related Disorders -- psychology KW - Membrane Transport Proteins -- metabolism KW - Methylphenidate -- administration & dosage KW - Methylphenidate -- pharmacology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reinforcement (Psychology) KW - Methylphenidate -- pharmacokinetics KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacokinetics KW - Brain -- diagnostic imaging KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72745935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Role+of+dopamine+in+the+therapeutic+and+reinforcing+effects+of+methylphenidate+in+humans%3A+results+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene+Jack%3BDing%2C+Yu+Shin%3BGatley%2C+Samuel+J&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-12-01&rft.volume=12&rft.issue=6&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-25 N1 - Date created - 2002-12-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - CPAPER T1 - Neuroimaging in HIV-related brain disease AN - 39537201; 3712438 AU - Chang, L Y1 - 2002/11/21/ PY - 2002 DA - 2002 Nov 21 KW - CPI, Conference Papers Index KW - U 2000:Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=&rft.atitle=Neuroimaging+in+HIV-related+brain+disease&rft.au=Chang%2C+L&rft.aulast=Chang&rft.aufirst=L&rft.date=2002-11-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - SuppNotes - Availability: Neuroscience 2002, c/o AKM Congress Service GmbH, Rheinterrasse Dusseldorf, Joseph-Beuys-Ufer 33, 40479 Dusseldorf, Germany; phone: 49 (0) 211-49 77 712; fax: 49 (0) 211-49 77 743. Paper No. 106 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Thermodynamics of common atmospheric particles on the nanoscale AN - 821965391; 2011-008226 JF - Eos, Transactions, American Geophysical Union AU - Onasch, Timothy AU - Han, Jeong-ho AU - Oatis, Susan AU - Brechtel, Frederick AU - Imre, Dan G AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 106 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - water KW - atmosphere KW - adsorption KW - temperature KW - size KW - deliquescence KW - humidity KW - efflorescence KW - volume KW - aerosols KW - thermodynamic properties KW - particles KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/821965391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Thermodynamics+of+common+atmospheric+particles+on+the+nanoscale&rft.au=Onasch%2C+Timothy%3BHan%2C+Jeong-ho%3BOatis%2C+Susan%3BBrechtel%2C+Frederick%3BImre%2C+Dan+G%3BAnonymous&rft.aulast=Onasch&rft.aufirst=Timothy&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2011-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - adsorption; aerosols; atmosphere; deliquescence; efflorescence; humidity; particles; size; temperature; thermodynamic properties; volume; water ER - TY - JOUR T1 - Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies. AN - 72837057; 12559839 AB - Drug addiction is characterized by a set of recurring processes (intoxication, withdrawal, craving) that lead to the relapsing nature of the disorder. We have used positron emission tomography to investigate in humans the role of dopamine (DA) and the brain circuits it regulates in these processes. We have shown that increases in DA are associated with the subjective reports of drug reinforcement corroborating the relevance of drug-induced DA increases in the rewarding effects of drugs in humans. During withdrawal we have shown in drug abusers significant reductions in DA D2 receptors and in DA release. We postulate that this hypodopaminergic state would result in a decreased sensitivity to natural reinforcers perpetuating the use of the drug as a means to compensate for this deficit and contributing to the anhedonia and dysphoria seen during withdrawal. Because the D2 reductions are associated with decreased activity in the anterior cingulate gyrus and in the orbitofrontal cortex we postulate that this is one of the mechanisms by which DA disruption leads to compulsive drug administration and the lack of control over drug intake in the drug-addicted individual. This is supported by studies showing that during craving these frontal regions become hyperactive in proportion to the intensity of the craving. Craving is also associated with activation of memory circuits including the amygdala (implicated in conditioned learning), hippocampus (implicated in declarative learning), and dorsal striatum (implicated in habit learning) all of which receive DA innervation. We therefore postulate that dopamine contributes to addiction by disrupting the frontal cortical circuits that regulate motivation, drive, and self-control and by memory circuits that increase the motivational salience of the drug and drug-associated stimuli. JF - Neurobiology of learning and memory AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Goldstein, Rita Z AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 610 EP - 624 VL - 78 IS - 3 SN - 1074-7427, 1074-7427 KW - Narcotics KW - 0 KW - Receptors, Dopamine KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Amygdala -- metabolism KW - Substance Withdrawal Syndrome -- etiology KW - Neural Pathways -- metabolism KW - Humans KW - Corpus Striatum -- metabolism KW - Hippocampus -- metabolism KW - Tomography, Emission-Computed KW - Narcotics -- adverse effects KW - Frontal Lobe -- physiopathology KW - Memory Disorders -- physiopathology KW - Frontal Lobe -- metabolism KW - Dopamine -- metabolism KW - Substance-Related Disorders -- metabolism KW - Memory Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72837057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+learning+and+memory&rft.atitle=Role+of+dopamine%2C+the+frontal+cortex+and+memory+circuits+in+drug+addiction%3A+insight+from+imaging+studies.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BGoldstein%2C+Rita+Z&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2002-11-01&rft.volume=78&rft.issue=3&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+learning+and+memory&rft.issn=10747427&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-03-21 N1 - Date created - 2003-01-31 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Carbon K-edge scanning transmission X-ray spectromicroscopy (STXM) of uranium binding to bacterial cells AN - 51715508; 2005-042222 JF - Eos, Transactions, American Geophysical Union AU - Gillow, J AU - Wirick, S AU - Feser, M AU - Jacobsen, C AU - Francis, A AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - F1397 EP - F1398 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - XANES spectra KW - laboratory studies KW - sorption KW - experimental studies KW - metals KW - carbon KW - bacteria KW - uranium KW - spectra KW - actinides KW - X-ray spectra KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51715508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Carbon+K-edge+scanning+transmission+X-ray+spectromicroscopy+%28STXM%29+of+uranium+binding+to+bacterial+cells&rft.au=Gillow%2C+J%3BWirick%2C+S%3BFeser%2C+M%3BJacobsen%2C+C%3BFrancis%2C+A%3BAnonymous&rft.aulast=Gillow&rft.aufirst=J&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=F1397&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - actinides; bacteria; carbon; experimental studies; laboratory studies; metals; sorption; spectra; uranium; X-ray spectra; XANES spectra ER - TY - JOUR T1 - Time-resolved structural analysis of cation exchange reactions in birnessite using synchrotron XRD AN - 51689780; 2005-056162 JF - Eos, Transactions, American Geophysical Union AU - Lopano, Christina L AU - Heaney, Peter J AU - Post, Jeffrey E AU - Hanson, Jonathan C AU - Lee, Yongjae AU - Komarneni, Sridhar AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1425 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - soils KW - experimental studies KW - X-ray diffraction data KW - substitution KW - crystal structure KW - Rietveld refinement KW - ground water KW - synchrotron radiation KW - laboratory studies KW - birnessite KW - time factor KW - oxides KW - cations KW - applications KW - lattice parameters KW - ion exchange KW - crystal chemistry KW - industrial minerals KW - geochemistry KW - synthetic materials KW - 01A:General mineralogy KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51689780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Time-resolved+structural+analysis+of+cation+exchange+reactions+in+birnessite+using+synchrotron+XRD&rft.au=Lopano%2C+Christina+L%3BHeaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BHanson%2C+Jonathan+C%3BLee%2C+Yongjae%3BKomarneni%2C+Sridhar%3BAnonymous&rft.aulast=Lopano&rft.aufirst=Christina&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=1425&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - applications; birnessite; cations; crystal chemistry; crystal structure; experimental studies; geochemistry; ground water; industrial minerals; ion exchange; laboratory studies; lattice parameters; oxides; Rietveld refinement; soils; substitution; synchrotron radiation; synthetic materials; time factor; X-ray diffraction data ER - TY - JOUR T1 - Thermal analyses of magnesioferrite AN - 51526053; 2006-086195 JF - Eos, Transactions, American Geophysical Union AU - Antao, S M AU - Hanson, J AU - Hassan, I AU - Chen, J AU - Parise, J B AU - Anonymous Y1 - 2002/11// PY - 2002 DA - November 2002 SP - 1 PB - American Geophysical Union, Washington, DC VL - 83 IS - 47, Suppl. SN - 0096-3941, 0096-3941 KW - X-ray diffraction data KW - thermogravimetric analysis KW - thermal properties KW - spinel KW - Rietveld refinement KW - temperature KW - thermal analysis KW - reagents KW - magnesioferrite KW - oxides KW - synchrotrons KW - thermal analysis data KW - high temperature KW - P-T conditions KW - calorimetry KW - 17A:General geophysics KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51526053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.atitle=Thermal+analyses+of+magnesioferrite&rft.au=Antao%2C+S+M%3BHanson%2C+J%3BHassan%2C+I%3BChen%2C+J%3BParise%2C+J+B%3BAnonymous&rft.aulast=Antao&rft.aufirst=S&rft.date=2002-11-01&rft.volume=83&rft.issue=47%2C+Suppl.&rft.spage=F606&rft.isbn=&rft.btitle=&rft.title=Eos%2C+Transactions%2C+American+Geophysical+Union&rft.issn=00963941&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2002 fall meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - PubXState - DC N1 - Last updated - 2012-06-07 N1 - CODEN - EOSTAJ N1 - SubjectsTermNotLitGenreText - calorimetry; high temperature; magnesioferrite; oxides; P-T conditions; reagents; Rietveld refinement; spinel; synchrotrons; temperature; thermal analysis; thermal analysis data; thermal properties; thermogravimetric analysis; X-ray diffraction data ER - TY - JOUR T1 - Genomic Signature Tags (GSTs): A System for Profiling Genomic DNA AN - 18557231; 5522781 AB - Genomic signature tags (GSTs) are the products of a method we have developed for identifying and quantitatively analyzing genomic DNAs. The DNA is initially fragmented with a type II restriction enzyme. An oligonucleotide adaptor containing a recognition site for MmeI, a type IIS restriction enzyme, is then used to release 21-bp tags from fixed positions in the DNA relative to the sites recognized by the fragmenting enzyme. These tags are PCR-amplified, purified, concatenated, and then cloned and sequenced. The tag sequences and abundances are used to create a high-resolution GST sequence profile of the genomic DNA. GSTs are shown to be long enough for use as oligonucleotide primers to amplify adjacent segments of the DNA, which can then be sequenced to provide additional nucleotide information or used as probes to identify specific clones in metagenomic libraries. GST analysis of the 4.7-Mb Yersinia pestis EV766 genome using BamHI as the fragmenting enzyme and NlaIII as the tagging enzyme validated the precision of our approach. The GST profile predicts that this strain has several changes relative to the archetype CO92 strain, including deletion of a 57-kb region of the chromosome known to be an unstable pathogenicity island. JF - Genome Research AU - Dunn, J J AU - McCorkle AU - Praissman, LA AU - Hind, G AU - Van Der Lelie, D AU - Bahou, W F AU - Gnatenko, D V AU - Krause, M K AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA, jdunn@bnl.gov Y1 - 2002/11// PY - 2002 DA - Nov 2002 SP - 1756 EP - 1765 VL - 12 IS - 11 SN - 1054-9803, 1054-9803 KW - pathogenicity islands KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - N 14610:Occurrence, isolation & assay KW - G 07191:Analysis techniques KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18557231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Genomic+Signature+Tags+%28GSTs%29%3A+A+System+for+Profiling+Genomic+DNA&rft.au=Dunn%2C+J+J%3BMcCorkle%3BPraissman%2C+LA%3BHind%2C+G%3BVan+Der+Lelie%2C+D%3BBahou%2C+W+F%3BGnatenko%2C+D+V%3BKrause%2C+M+K&rft.aulast=Dunn&rft.aufirst=J&rft.date=2002-11-01&rft.volume=12&rft.issue=11&rft.spage=1756&rft.isbn=&rft.btitle=&rft.title=Genome+Research&rft.issn=10549803&rft_id=info:doi/10.1101%2Fgr.306102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1101/gr.306102 ER - TY - JOUR T1 - Anthropogenic aerosols: Indirect warming effect from dispersion forcing AN - 19923819; 5467235 AB - Anthropogenic aerosols enhance cloud reflectivity by increasing the number concentration of cloud droplets, leading to a cooling effect on climate that is referred to as the Twomey effect. Here we show that anthropogenic aerosols exert an additional effect on cloud properties that is derived from changes in the spectral shape of the size distribution of cloud droplets in polluted air and acts to diminish this cooling. This finding could help to improve our understanding of the indirect aerosol effect and its treatment in climate modelling. JF - Nature AU - Liu, Y AU - Daum, PH AD - Brookhaven National Laboratory, Upton, New York 11973, USA, lyg@bnl.gov Y1 - 2002/10/10/ PY - 2002 DA - 2002 Oct 10 SP - 580 EP - 581 PB - Macmillan Publishers Ltd. VL - 419 IS - 6907 SN - 0028-0836, 0028-0836 KW - Twomey effect KW - Sustainability Science Abstracts; Pollution Abstracts; Oceanic Abstracts; Human Population; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 2: Ocean Technology Policy & Non-Living Resources KW - Particle size KW - Atmospheric particulates KW - Aerosols KW - Reflectance KW - anthropogenic factors KW - Albedo KW - Climatic changes KW - Man-induced effects KW - Pollution effects KW - Cloud physics KW - Air pollution KW - Clouds KW - Global warming KW - Population-environment relations KW - Size distribution KW - Q2 09243:Structure, mechanics and thermodynamics KW - P 0000:AIR POLLUTION KW - M3 1010:Issues in Sustainable Development KW - O 2070:Meteorology KW - Q5 08521:Mechanical and natural changes KW - O 4060:Pollution - Environment KW - M1 110:Population-Environment Relations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19923819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Anthropogenic+aerosols%3A+Indirect+warming+effect+from+dispersion+forcing&rft.au=Liu%2C+Y%3BDaum%2C+PH&rft.aulast=Liu&rft.aufirst=Y&rft.date=2002-10-10&rft.volume=419&rft.issue=6907&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Clouds; Particle size; Air pollution; Atmospheric particulates; Aerosols; Reflectance; Albedo; Climatic changes; Pollution effects; Man-induced effects; Cloud physics; Size distribution; Global warming; Population-environment relations; anthropogenic factors ER - TY - JOUR T1 - The role of dopamine in motivation for food in humans: implications for obesity. AN - 72193095; 12387683 AB - Obesity is a major public health problem. The increasing number of obese individuals in the US adds urgency to the efforts to understand the mechanisms underlying pathological overeating. Imaging studies using positron emission tomography implicate the involvement of brain dopamine (DA) in normal and pathological food intake in humans. In normal body weight, fasting subjects, food presentation that could not be consumed was associated with increases in striatal extracellular DA, which provides evidence of an involvement of DA in non-hedonic motivational properties of food intake. In pathologically obese subjects, the authors showed reductions in striatal D2 receptor availability that were inversely associated with the weight of the subject. The involvement of the DA system in reward and reinforcement has led to the hypothesis that low brain DA activity in obese subjects predisposes them to excessive use of food. A better understanding of the role of the DA system in the motivation for food intake will help the development of better therapeutic interventions. JF - Expert opinion on therapeutic targets AU - Wang, Gene-Jack AU - Volkow, Nora D AU - Fowler, Joanna S AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. gjwang@bnl.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 601 EP - 609 VL - 6 IS - 5 KW - Dopamine Agonists KW - 0 KW - Dopamine Antagonists KW - Dopamine D2 Receptor Antagonists KW - Receptors, Dopamine KW - Receptors, Dopamine D2 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Receptors, Dopamine -- drug effects KW - Animals KW - Hypothalamus -- physiology KW - Feeding and Eating Disorders -- genetics KW - Limbic System -- physiology KW - Methylphenidate -- pharmacology KW - Brain Chemistry KW - Corpus Striatum -- metabolism KW - Humans KW - Receptors, Dopamine D2 -- physiology KW - Satiation -- physiology KW - Rats KW - Receptors, Dopamine -- physiology KW - Reward KW - Dopamine Agonists -- pharmacology KW - Feeding and Eating Disorders -- physiopathology KW - Dopamine Antagonists -- toxicity KW - Receptors, Dopamine D2 -- genetics KW - Substance-Related Disorders -- genetics KW - Obesity -- drug therapy KW - Obesity -- prevention & control KW - Obesity -- etiology KW - Feeding Behavior -- physiology KW - Dopamine -- physiology KW - Appetite -- drug effects KW - Obesity -- physiopathology KW - Obesity -- chemically induced KW - Feeding Behavior -- drug effects KW - Appetite -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72193095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+therapeutic+targets&rft.atitle=The+role+of+dopamine+in+motivation+for+food+in+humans%3A+implications+for+obesity.&rft.au=Wang%2C+Gene-Jack%3BVolkow%2C+Nora+D%3BFowler%2C+Joanna+S&rft.aulast=Wang&rft.aufirst=Gene-Jack&rft.date=2002-10-01&rft.volume=6&rft.issue=5&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+therapeutic+targets&rft.issn=1744-7631&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-08-25 N1 - Date created - 2002-10-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. AN - 72139389; 12359667 AB - OBJECTIVEStudies of the neurobiological processes underlying drug addiction primarily have focused on limbic subcortical structures. Here the authors evaluated the role of frontal cortical structures in drug addiction.METHODAn integrated model of drug addiction that encompasses intoxication, bingeing, withdrawal, and craving is proposed. This model and findings from neuroimaging studies on the behavioral, cognitive, and emotional processes that are at the core of drug addiction were used to analyze the involvement of frontal structures in drug addiction.RESULTSThe orbitofrontal cortex and the anterior cingulate gyrus, which are regions neuroanatomically connected with limbic structures, are the frontal cortical areas most frequently implicated in drug addiction. They are activated in addicted subjects during intoxication, craving, and bingeing, and they are deactivated during withdrawal. These regions are also involved in higher-order cognitive and motivational functions, such as the ability to track, update, and modulate the salience of a reinforcer as a function of context and expectation and the ability to control and inhibit prepotent responses.CONCLUSIONSThese results imply that addiction connotes cortically regulated cognitive and emotional processes, which result in the overvaluing of drug reinforcers, the undervaluing of alternative reinforcers, and deficits in inhibitory control for drug responses. These changes in addiction, which the authors call I-RISA (impaired response inhibition and salience attribution), expand the traditional concepts of drug dependence that emphasize limbic-regulated responses to pleasure and reward. JF - The American journal of psychiatry AU - Goldstein, Rita Z AU - Volkow, Nora D AD - Medical Research, Brookhaven National Laboratory, Bldg. 490, 30 Bell Avenue, Upton, NY 11973, USA. rgoldstein@bnl.gov Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 1642 EP - 1652 VL - 159 IS - 10 SN - 0002-953X, 0002-953X KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Limbic System -- physiopathology KW - Substance Withdrawal Syndrome -- physiopathology KW - Cerebral Cortex -- metabolism KW - Humans KW - Reinforcement (Psychology) KW - Dopamine -- physiology KW - Terminology as Topic KW - Behavior, Addictive -- physiopathology KW - Cerebral Cortex -- physiopathology KW - Compulsive Behavior -- physiopathology KW - Syndrome KW - Cocaine-Related Disorders -- physiopathology KW - Tomography, Emission-Computed KW - Cocaine-Related Disorders -- metabolism KW - Models, Theoretical KW - Substance-Related Disorders -- physiopathology KW - Frontal Lobe -- physiopathology KW - Frontal Lobe -- diagnostic imaging KW - Frontal Lobe -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72139389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Drug+addiction+and+its+underlying+neurobiological+basis%3A+neuroimaging+evidence+for+the+involvement+of+the+frontal+cortex.&rft.au=Goldstein%2C+Rita+Z%3BVolkow%2C+Nora+D&rft.aulast=Goldstein&rft.aufirst=Rita&rft.date=2002-10-01&rft.volume=159&rft.issue=10&rft.spage=1642&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-23 N1 - Date created - 2002-10-02 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Cited By: Am J Psychiatry. 2001 Mar;158(3):377-82 [11229977] J Psychoactive Drugs. 2000 Nov;32 Suppl:i-iv, 1-112 [11280926] Annu Rev Neurosci. 2001;24:167-202 [11283309] J Neurosci. 2001 Apr 15;21(8):2793-8 [11306631] J Neurosci. 2001 Jun 1;21(11):4090-103 [11356897] Neuron. 2001 May;30(2):619-39 [11395019] Neuroreport. 2001 Aug 8;12(11):2595-9 [11496155] J Neurochem. 2001 Sep;78(5):1094-103 [11553683] Am J Psychiatry. 2001 Dec;158(12):2015-21 [11729018] Biol Psychiatry. 2002 Jan 15;51(2):134-42 [11822992] Psychopharmacology (Berl). 1981;73(4):318-22 [6789351] J Pharmacol Exp Ther. 1985 Dec;235(3):677-82 [4078729] Pharmacol Biochem Behav. 1986 Jul;25(1):191-9 [3018792] Science. 1987 Sep 4;237(4819):1219-23 [2820058] Psychiatry Res. 1988 May;24(2):201-9 [3261427] Br J Psychiatry. 1988 May;152:641-8 [3262397] Synapse. 1989;3(1):48-54 [2537539] Pharmacol Rev. 1989 Mar;41(1):3-52 [2682679] Arch Gen Psychiatry. 1990 Jan;47(1):73-81 [2403775] Psychol Rev. 1990 Apr;97(2):147-68 [2186423] Am J Psychiatry. 1990 Jun;147(6):719-24 [2343913] Psychopharmacology (Berl). 1990;101(2):262-6 [2349367] Arch Gen Psychiatry. 1990 Jun;47(6):567-74 [2350209] Psychiatry Res. 1990 Apr;35(1):39-48 [2164230] Alcohol Clin Exp Res. 1990 Jun;14(3):482-9 [2198826] Am J Psychiatry. 1991 May;148(5):621-6 [2018164] Neuropsychopharmacology. 1991 May;4(3):175-86 [2064717] Alcohol Clin Exp Res. 1991 Jun;15(3):418-27 [1877728] Neuropsychopharmacology. 1998 Apr;18(4):243-52 [9509492] Science. 1998 May 1;280(5364):747-9 [9563953] J Stud Alcohol. 1998 May;59(3):258-69 [9598706] Pharmacol Biochem Behav. 1999 Nov;64(3):597-604 [10548277] Psychol Med. 1998 May;28(3):559-71 [9626713] Exp Brain Res. 1998 Jun;120(3):386-98 [9628425] Proc Biol Sci. 1998 Oct 22;265(1409):1927-31 [9821359] Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14494-9 [9826728] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] Am J Psychiatry. 1999 Jan;156(1):19-26 [9892293] J Nucl Med. 1999 Jan;40(1):19-24 [9935051] Psychopharmacology (Berl). 1999 Jan;141(1):99-106 [9952071] Life Sci. 1999;64(9):775-84 [10075110] Nat Neurosci. 1999 Jan;2(1):11-2 [10195173] Neuroreport. 1999 Feb 25;10(3):453-9 [10208571] Neuropsychologia. 1999 Apr;37(4):403-11 [10215087] Am J Psychiatry. 1999 May;156(5):675-82 [10327898] Brain. 1999 May;122 ( Pt 5):883-93 [10355673] Neuroimage. 1999 Jun;9(6 Pt 1):563-71 [10334900] Science. 1999 Jun 18;284(5422):1979-81 [10373114] Eur J Pharmacol. 1999 Jun 30;375(1-3):13-30 [10443561] Am J Psychiatry. 1999 Sep;156(9):1440-3 [10484959] Neuroscience. 1999;93(4):1359-67 [10501460] J Neurosci. 1999 Oct 15;19(20):9029-38 [10516320] Am J Psychiatry. 1998 Aug;155(8):1009-15 [9699686] J Neurosci. 1997 Apr 15;17(8):2796-806 [9092601] Nature. 1997 Apr 24;386(6627):830-3 [9126741] Alcohol Clin Exp Res. 1997 May;21(3):521-9 [9161613] Neuroreport. 1997 Mar 24;8(5):1225-8 [9175118] Science. 1997 Aug 15;277(5328):968-71 [9252330] Neuron. 1997 Sep;19(3):591-611 [9331351] Behav Brain Res. 1997 Sep;87(2):139-48 [9331482] Alcohol Clin Exp Res. 1997 Oct;21(7):1278-84 [9347090] Psychopharmacology (Berl). 1999 Oct;146(4):373-90 [10550488] J Neuropsychiatry Clin Neurosci. 1999 Fall;11(4):426-35 [10570754] Neurosci Biobehav Rev. 2000 Jan;24(1):13-9 [10654655] Psychiatry Res. 1999 Dec 20;92(2-3):75-81 [10674361] Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1944-8 [10677559] Cereb Cortex. 2000 Mar;10(3):272-84 [10731222] Cereb Cortex. 2000 Mar;10(3):318-25 [10731226] Psychophysiology. 2000 Mar;37(2):216-23 [10731771] Keio J Med. 2000 Feb;49 Suppl 1:A122-4 [10750360] Neuroreport. 2000 Jun 5;11(8):1739-44 [10852235] Eur J Neurosci. 2000 Jun;12(6):2097-106 [10886349] Am J Psychiatry. 2000 Nov;157(11):1789-98 [11058476] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] Am J Psychiatry. 2001 Jan;158(1):86-95 [11136638] Synapse. 2001 Mar 1;39(3):257-66 [11169774] Synapse. 1992 Jul;11(3):184-90 [1636149] Am J Psychiatry. 1992 Aug;149(8):1016-22 [1636801] J Cereb Blood Flow Metab. 1992 Sep;12(5):750-8 [1324250] Neurosci Biobehav Rev. 1992 Winter;16(4):525-34 [1480349] Am J Psychiatry. 1993 Mar;150(3):417-22 [8382010] Am J Psychiatry. 1993 May;150(5):713-9 [8480815] Synapse. 1993 Jun;14(2):169-77 [8101394] J Neuropsychiatry Clin Neurosci. 1993 Fall;5(4):384-94 [8286936] Am J Psychiatry. 1994 Feb;151(2):178-83 [8296885] Am J Psychiatry. 1994 Oct;151(10):1505-8 [8092344] Psychopharmacology (Berl). 1993;113(1):123-30 [7862818] J Consult Clin Psychol. 1995 Jun;63(3):400-7 [7608352] Neuroreport. 1995 Sep 11;6(13):1723-8 [8541468] J Neurochem. 1996 Feb;66(2):589-98 [8592128] NIDA Res Monogr. 1994;145:1-18 [8742805] Psychiatry Res. 1996 May 31;67(1):29-38 [8797240] J Neurophysiol. 1996 Jan;75(1):142-53 [8822548] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Psychopharmacology (Berl). 1996 Nov;128(1):17-20 [8944401] Alcohol Clin Exp Res. 1996 Dec;20(9):1594-8 [8986209] Neuropsychopharmacology. 1997 Feb;16(2):174-82 [9015800] Neuropsychologia. 1997 Oct;35(10):1395-404 [9347486] Am J Psychiatry. 1998 Jan;155(1):124-6 [9433350] Neuroreport. 1997 Dec 22;8(18):3969-72 [9462476] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Later Pleistocene/Holocene climate conditions of Qinghai-Xizhang Plateau (Tibet) based on carbon and oxygen stable isotopes of Zabuye Lake sediments AN - 52035049; 2003-006668 AB - We present a time series of carbon and oxygen stable isotope records of the last 30 000 (super 14) C years throughout the last glacial-postglacial cycle from western Qinghai-Xizhang (Tibet) Plateau. A 20-m core drilled in the south basin of Zabuye Salt Lake was analyzed for inorganic and organic carbon and total sulfur contents, delta (super 13) C and delta (super 18) O values of carbonates. Our results indicate that climatic changes have led to a drastic negative shift of stable isotope ratios at the transition between the Last Full Glacial and the postglacial phase during Later Pleistocene times ( approximately 16.2 kyr BP), and a rapid positive shift at the transition from Pleistocene to Holocene ( approximately 10.6 kyr BP). The first shift is marked by the drop of delta (super 18) O (sub carb) values of about 10 per mil (from +2 to -8 per mil) and delta (super 13) C (sub carb) values of about 3 per mil (from 5 to 2 per mil). The second shift which occurred at the transition from Pleistocene to Holocene was of similar magnitude but in the opposite direction. Isotope data, combined with total organic and inorganic carbon contents and the lithological composition of the core, suggest this lake was an alluvial pre-lake environment prior to ca. 28 (super 14) C kyr BP. During ca. 28-16.2 (super 14) C kyr BP, Zabuye Lake was likely a moderately deep lake with limited outflow. The cool and arid glacial climate led the lake level to drop drastically. Extended residence time overwhelmed the lower temperature and caused a steady increase of delta (super 13) C (sub carb) and delta (super 18) O (sub carb) values and total inorganic carbon content in the sediments. During ca. 16.2-10.6 (super 14) C kyr BP, this lake probably overflowed and received abundant recharge from melting glaciers when the deglaciation was in its full speed. A spike of markedly enhanced delta (super 13) C (sub carb) and delta (super 18) O (sub carb) is seen at approximately 11.5 kyr BP, probably due to the isotopic effects left behind by the short but severe Younger Dryas (YD) event. After ca. 10.6 (super 14) C kyr BP, Zabuye Lake probably closed its surface outflow, due to strong desiccation and drastic climate warming. The Early and Middle Holocene were characterized by unstable climatic conditions with alternating warmer/cooler episodes as indicated by the severe fluctuations of total organic carbon, delta (super 13) C and delta (super 18) O values. A hypersaline salt lake environment was finally formed at Zabuye after approximately 5 (super 14) C kyr BP when the mirabilite and halite concentrations steadily increased and became the dominant minerals in the sediments. Severe imbalance of inflow/outflow resulted in the drastic increase of total sulfur, delta (super 13) C (sub carb) and delta (super 18) O (sub carb) values and dominance of halite in the lake since ca. 3.8 kyr BP to present. JF - Earth and Planetary Science Letters AU - Wang, R L AU - Scarpitta, S C AU - Zhang, S C AU - Zheng, M P Y1 - 2002/10// PY - 2002 DA - October 2002 SP - 461 EP - 477 PB - Elsevier, Amsterdam VL - 203 IS - 1 SN - 0012-821X, 0012-821X KW - last glacial maximum KW - Far East KW - oxygen KW - glaciation KW - isotopes KW - postglacial environment KW - lakes KW - paleoclimatology KW - Holocene KW - stable isotopes KW - deglaciation KW - cores KW - climate change KW - upper Pleistocene KW - Cenozoic KW - radioactive isotopes KW - melting KW - paleolimnology KW - dates KW - Xizang China KW - total organic carbon KW - carbon KW - Tibetan Plateau KW - glacial environment KW - sediments KW - absolute age KW - organic carbon KW - Asia KW - geochemistry KW - China KW - salt lakes KW - Quaternary KW - paleohydrology KW - isotope ratios KW - C-13/C-12 KW - glaciers KW - O-18/O-16 KW - inorganic materials KW - organic compounds KW - Zabuye Lake KW - residence time KW - lacustrine environment KW - sulfur KW - Pleistocene KW - glacial geology KW - C-14 KW - lake sediments KW - 24:Quaternary geology KW - 02D:Isotope geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52035049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Earth+and+Planetary+Science+Letters&rft.atitle=Later+Pleistocene%2FHolocene+climate+conditions+of+Qinghai-Xizhang+Plateau+%28Tibet%29+based+on+carbon+and+oxygen+stable+isotopes+of+Zabuye+Lake+sediments&rft.au=Wang%2C+R+L%3BScarpitta%2C+S+C%3BZhang%2C+S+C%3BZheng%2C+M+P&rft.aulast=Wang&rft.aufirst=R&rft.date=2002-10-01&rft.volume=203&rft.issue=1&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Earth+and+Planetary+Science+Letters&rft.issn=0012821X&rft_id=info:doi/10.1016%2FS0012-821X%2802%2900829-4 L2 - http://www.sciencedirect.com/science/journal/0012821X LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2003-01-01 N1 - Number of references - 41 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - CODEN - EPSLA2 N1 - SubjectsTermNotLitGenreText - absolute age; Asia; C-13/C-12; C-14; carbon; Cenozoic; China; climate change; cores; dates; deglaciation; Far East; geochemistry; glacial environment; glacial geology; glaciation; glaciers; Holocene; inorganic materials; isotope ratios; isotopes; lacustrine environment; lake sediments; lakes; last glacial maximum; melting; O-18/O-16; organic carbon; organic compounds; oxygen; paleoclimatology; paleohydrology; paleolimnology; Pleistocene; postglacial environment; Quaternary; radioactive isotopes; residence time; salt lakes; sediments; stable isotopes; sulfur; Tibetan Plateau; total organic carbon; upper Pleistocene; Xizang China; Zabuye Lake DO - http://dx.doi.org/10.1016/S0012-821X(02)00829-4 ER - TY - BOOK T1 - A Scoping Study on the Core Damage Frequency Impact of Cable Failures Due to Harsh Environment in a PWR and a BWR AN - 21022459; 10882780 AB - The automatic and manual operation of safety systems in a nuclear power plant (NPP) rely on cables and related equipment, such as electrical penetration assemblies and terminations, for power, control, and instrumentation signals. During an accident that creates a harsh environment, the cables need to perform reliably to operate the electrical equipment to meet the system's performance requirements. The performance capability of cables during accidents is addressed through environmental qualification of electrical equipment. In this paper, we present a scoping study of the impact of cable failures on the NPP's risk using core damage frequency (CDF) as the risk measure. We assess the impact of cable failures due to the harsh environment using the probabilistic risk assessment (PRA) model of the internal initiators in a plant. However, in the PRA of NPPs, the cable reliability in a harsh environment is typically assumed to remain unaffected. Also, typically, cables are not explicitly modeled in a PRA, and the effect of their failure on hardware and operator's actions is not directly addressed. We use existing PRA models to evaluate the impact of cable failures through the modeled component's and operator's actions. Several assumptions are made. Sensitivity analyses are conducted to assess the impact of failures of cables providing different functions inside the containment. The impact on CDF and the accident sequences that become dominant contributors when cables fail are studied. The relative CDF significance of cables providing different functions is obtained. A pressurized water reactor (PWR) plant, Surry Nuclear Power Station, and a boiling water reactor (BWR) plant, Peach Bottom Station, are studied. JF - WIRE SYSTEM AGING. AU - Samanta, P K AU - Martinez-Guridi, G Y1 - 2002/10// PY - 2002 DA - Oct 2002 PB - U.S. Nuclear Regulatory Commission KW - Health & Safety Science Abstracts KW - Risk assessment KW - safety systems KW - Prunus KW - commissions KW - Accidents KW - sensitivity analysis KW - Power plants KW - Containment KW - aging KW - Conferences KW - Nuclear power plants KW - USA KW - Nuclear reactors KW - electrical equipment KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21022459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Health+%26+Safety+Science+Abstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Samanta%2C+P+K%3BMartinez-Guridi%2C+G&rft.aulast=Samanta&rft.aufirst=P&rft.date=2002-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+Scoping+Study+on+the+Core+Damage+Frequency+Impact+of+Cable+Failures+Due+to+Harsh+Environment+in+a+PWR+and+a+BWR&rft.title=A+Scoping+Study+on+the+Core+Damage+Frequency+Impact+of+Cable+Failures+Due+to+Harsh+Environment+in+a+PWR+and+a+BWR&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 ER - TY - JOUR T1 - Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies. AN - 72519977; 12394411 AB - The involvement of dopamine (DA) in drug reinforcement is well established, but much less in known about its contribution to addiction. We have used positron emission tomography to investigate in humans the role of DA in drug reinforcement, addiction and drug vulnerability. We have shown that during drug intoxication increases in striatal DA are associated with the drug's reinforcing effects only if the DA changes occur rapidly. These results corroborate the relevance of drug-induced DA increases and of pharmacokinetics in the rewarding effects of drugs in humans. During withdrawal, we have shown significant reductions in DA D(2) receptors and in DA release in drug abusers, which is likely to result in decreased sensitivity to non-drug-related reinforcing stimuli. The DA D(2) reductions were associated with decreased activity in the orbitofrontal cortex, which we postulate is one of the mechanisms underlying compulsive drug administration in the addict. In fact, during craving the orbitofrontal cortex becomes hyperactive in proportion to the desire for the drug. In non-drug-abusing subjects striatal DA D(2) receptors levels predicted the reinforcing responses to stimulant drugs, providing evidence that striatal DA D(2) receptors modulate reinforcing responses to stimulants in humans and may contribute to the predisposition for drug self-administration. JF - Behavioural pharmacology AU - Volkow, N D AU - Fowler, J S AU - Wang, G-J AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 355 EP - 366 VL - 13 IS - 5-6 SN - 0955-8810, 0955-8810 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Receptors, Dopamine D2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Neurons -- metabolism KW - Humans KW - Tomography, Emission-Computed KW - Membrane Transport Proteins -- drug effects KW - Membrane Transport Proteins -- metabolism KW - Receptors, Dopamine D2 -- metabolism KW - Substance-Related Disorders -- pathology KW - Reinforcement (Psychology) KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Substance-Related Disorders -- diagnostic imaging KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72519977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+pharmacology&rft.atitle=Role+of+dopamine+in+drug+reinforcement+and+addiction+in+humans%3A+results+from+imaging+studies.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G-J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2002-09-01&rft.volume=13&rft.issue=5-6&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Behavioural+pharmacology&rft.issn=09558810&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-12-23 N1 - Date created - 2002-10-23 N1 - Date revised - 2017-02-17 N1 - SuppNotes - Comment On: Behav Pharmacol. 2002 Sep;13(5-6):371-7 [12394413] Behav Pharmacol. 2002 Sep;13(5-6):367-70 [12394412] N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A temperature-resolved synchrotron X-ray diffraction study of thermal decomposition in end-member and cation-exchanged hydrotalcite AN - 51681339; 2005-063929 JF - Abstracts of the ... General Meeting of the International Mineralogical Association AU - Heaney, P J AU - Post, Jeffrey E AU - Hanson, J AU - Komarneni, S AU - Parsons, Ian Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 91 EP - 92 PB - International Mineralogical Association, [location varies] VL - 18 KW - zinc KW - alkaline earth metals KW - magnesium KW - hydrotalcite KW - experimental studies KW - X-ray diffraction data KW - thermal alteration KW - copper KW - Rietveld refinement KW - powder method KW - synchrotron radiation KW - laboratory studies KW - metals KW - cations KW - ion exchange KW - crystal chemistry KW - carbonates KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51681339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.atitle=A+temperature-resolved+synchrotron+X-ray+diffraction+study+of+thermal+decomposition+in+end-member+and+cation-exchanged+hydrotalcite&rft.au=Heaney%2C+P+J%3BPost%2C+Jeffrey+E%3BHanson%2C+J%3BKomarneni%2C+S%3BParsons%2C+Ian&rft.aulast=Heaney&rft.aufirst=P&rft.date=2002-09-01&rft.volume=18&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 18th general meeting of the International Mineralogical Association N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - #03852 N1 - SubjectsTermNotLitGenreText - alkaline earth metals; carbonates; cations; copper; crystal chemistry; experimental studies; hydrotalcite; ion exchange; laboratory studies; magnesium; metals; powder method; Rietveld refinement; synchrotron radiation; thermal alteration; X-ray diffraction data; zinc ER - TY - JOUR T1 - Neutron and temperature-resolved synchrotron X-ray powder diffraction study of akaganeite AN - 51679101; 2005-063917 JF - Abstracts of the ... General Meeting of the International Mineralogical Association AU - Post, Jeffrey E AU - Heaney, P J AU - Von Dreele, R B AU - Hanson, J AU - Parsons, Ian Y1 - 2002/09// PY - 2002 DA - September 2002 SP - 88 EP - 89 PB - International Mineralogical Association, [location varies] VL - 18 KW - chlorine KW - experimental studies KW - refinement KW - X-ray diffraction data KW - halogens KW - unit cell KW - crystal structure KW - Rietveld refinement KW - powder method KW - temperature KW - order-disorder KW - synchrotron radiation KW - laboratory studies KW - akaganeite KW - hydrogen KW - neutron diffraction data KW - oxides KW - crystal chemistry KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51679101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.atitle=Neutron+and+temperature-resolved+synchrotron+X-ray+powder+diffraction+study+of+akaganeite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+P+J%3BVon+Dreele%2C+R+B%3BHanson%2C+J%3BParsons%2C+Ian&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2002-09-01&rft.volume=18&rft.issue=&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Abstracts+of+the+...+General+Meeting+of+the+International+Mineralogical+Association&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 18th general meeting of the International Mineralogical Association N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - #03852 N1 - SubjectsTermNotLitGenreText - akaganeite; chlorine; crystal chemistry; crystal structure; experimental studies; halogens; hydrogen; laboratory studies; neutron diffraction data; order-disorder; oxides; powder method; refinement; Rietveld refinement; synchrotron radiation; temperature; unit cell; X-ray diffraction data ER - TY - JOUR T1 - Association of uranium with iron oxides typically formed on corroding steel surfaces. AN - 72067119; 12214641 AB - Decontamination of metal surfaces contaminated with low levels of radionuclides is a major concern at Department of Energy facilities. The development of an environmentally friendly and cost-effective decontamination process requires an understanding of their association with the corroding surfaces. We investigated the association of uranium with the amorphous and crystalline forms of iron oxides commonly formed on corroding steel surfaces. Uranium was incorporated with the oxide by addition during the formation of ferrihydrite, goethite, green rust II, lepidocrocite, maghemite, and magnetite. X-ray diffraction confirmed the mineralogical form of the oxide. EXAFS analysis at the U L(III) edge showed that uranium was present in hexavalent form as a uranyl oxyhydroxide species with goethite, maghemite, and magnetite and as a bidentate inner-sphere complex with ferrihydrite and lepidocrocite. Iron was present in the ferric form with ferrihydrite, goethite, lepidocrocite, and maghemite; whereas with magnetite and green rust II, both ferrous and ferric forms were present with characteristic ferrous:total iron ratios of 0.65 and 0.73, respectively. In the presence of the uranyl ion, green rust II was converted to magnetite with concomitantreduction of uranium to its tetravalent form. The rate and extent of uranium dissolution in dilute HCl depended on its association with the oxide: uranium present as oxyhydroxide species underwent rapid dissolution followed by a slow dissolution of iron; whereas uranium present as an inner-sphere complex with iron resulted in concomitant dissolution of the uranium and iron. JF - Environmental science & technology AU - Dodge, C J AU - Francis, A J AU - Gillow, J B AU - Halada, G P AU - Eng, C AU - Clayton, C R AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, New York 11973, USA. dodge1@bnl.gov Y1 - 2002/08/15/ PY - 2002 DA - 2002 Aug 15 SP - 3504 EP - 3511 VL - 36 IS - 16 SN - 0013-936X, 0013-936X KW - Ferric Compounds KW - 0 KW - Steel KW - 12597-69-2 KW - ferric oxide KW - 1K09F3G675 KW - Uranium KW - 4OC371KSTK KW - Index Medicus KW - Solubility KW - Corrosion KW - Environmental Pollution -- prevention & control KW - Steel -- chemistry KW - Ferric Compounds -- analysis KW - Ferric Compounds -- chemistry KW - Uranium -- chemistry KW - Uranium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72067119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Association+of+uranium+with+iron+oxides+typically+formed+on+corroding+steel+surfaces.&rft.au=Dodge%2C+C+J%3BFrancis%2C+A+J%3BGillow%2C+J+B%3BHalada%2C+G+P%3BEng%2C+C%3BClayton%2C+C+R&rft.aulast=Dodge&rft.aufirst=C&rft.date=2002-08-15&rft.volume=36&rft.issue=16&rft.spage=3504&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-29 N1 - Date created - 2002-09-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - A Novel Mechanism for Clostridium botulinum Neurotoxin Inhibition AN - 18698909; 5594428 AB - Clostridium botulinum neurotoxins are zinc endopeptidase proteins responsible for cleaving specific peptide bonds of proteins of neuroexocytosis apparatus. The ability of drugs to interfere with toxin's catalytic activity is being evaluated with zinc chelators and metalloprotease inhibitors. It is important to develop effective pharmacological treatment for the intact holotoxin before the catalytic domain separates and enters the cytosol. We present here evidence for a novel mechanism of an inhibitor binding to the holotoxin and for the chelation of zinc from our structural studies on Clostridium botulinum neurotoxin type B in complex with a potential metalloprotease inhibitor, bis(5-amidino-2-benzimidazolyl)methane, and provide snapshots of the reaction as it progresses. The binding and inhibition mechanism of this inhibitor to the neurotoxin seems to be unique for intact botulinum neurotoxins. The environment of the active site rearranges in the presence of the inhibitor, and the zinc ion is gradually removed from the active site and transported to a different site in the protein, probably causing loss of catalytic activity. JF - Biochemistry (Washington) AU - Eswaramoorthy, S AU - Kumaran, D AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA Y1 - 2002/08/06/ PY - 2002 DA - 2002 Aug 06 SP - 9795 EP - 9802 VL - 41 IS - 31 SN - 0006-2960, 0006-2960 KW - bis(5-amidino-2-benzimidazolyl)methane KW - inhibition KW - peptide bonds KW - zinc endopeptidase KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - J 02822:Biosynthesis and physicochemical properties KW - X 24171:Microbial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18698909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=A+Novel+Mechanism+for+Clostridium+botulinum+Neurotoxin+Inhibition&rft.au=Eswaramoorthy%2C+S%3BKumaran%2C+D%3BSwaminathan%2C+S&rft.aulast=Eswaramoorthy&rft.aufirst=S&rft.date=2002-08-06&rft.volume=41&rft.issue=31&rft.spage=9795&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi020060c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bi020060c ER - TY - JOUR T1 - Biological effects of polychromatic light. AN - 72023448; 12194212 AB - Predicting the effects of polychromatic light on biological systems is a central goal of environmental photobiology. If the dose-response function for a process is a linear function of the light incident on a system at each wavelength within the spectrum, the effect of a polychromatic spectrum is obtained by integrating the product of the cross section for the reaction at each wavelength and the spectral irradiance at that wavelength over both wavelength and time. This procedure cannot be used, however, if the dose-response functions for an effect are not linear functions of photon dose. Although many photochemical reactions are linear within the biologically relevant range of doses, many biological end points are not. I describe procedures for calculating the effects of polychromatic irradiations on systems that exhibit certain classes of dose-response functions, including power law responses typical of mutation induction and exponential dose-responses typical of cell survival. I also present an approach to predict the effects of polychromatic spectra on systems in which the ultraviolet components form pyrimidine dimers, and the longer-wavelength ultraviolet and visible components remove them by photoreactivation, thus generating complex dose-response functions for these coupled light-driven reactions. JF - Photochemistry and photobiology AU - Sutherland, John C AD - Biology Department, Brookhaven National Laboratory, Upton, NY, USA. sutherlandj@mail.ecu.edu Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 164 EP - 170 VL - 76 IS - 2 SN - 0031-8655, 0031-8655 KW - Pyrimidine Dimers KW - 0 KW - Index Medicus KW - DNA Damage KW - Pyrimidine Dimers -- radiation effects KW - Dose-Response Relationship, Radiation KW - Models, Biological KW - Photobiology KW - Light UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72023448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Biological+effects+of+polychromatic+light.&rft.au=Sutherland%2C+John+C&rft.aulast=Sutherland&rft.aufirst=John&rft.date=2002-08-01&rft.volume=76&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-10-04 N1 - Date created - 2002-08-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Aerosols; the colloids of the atmosphere AN - 51868741; 2004-025576 JF - Geochimica et Cosmochimica Acta AU - Buseck, Peter R AU - Schwartz, Stephen E AU - Anonymous Y1 - 2002/08// PY - 2002 DA - August 2002 SP - 111 PB - Pergamon, Oxford VL - 66 IS - 15A SN - 0016-7037, 0016-7037 KW - electron diffraction data KW - characterization KW - suspended materials KW - climate change KW - human ecology KW - sediments KW - ecology KW - spectra KW - particulate materials KW - nitrate ion KW - geochemistry KW - clouds KW - experimental studies KW - colloidal materials KW - sulfate ion KW - clastic sediments KW - human activity KW - atmosphere KW - X-ray spectra KW - TEM data KW - organic compounds KW - dust KW - solar radiation KW - sulfur KW - aerosols KW - public health KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51868741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geochimica+et+Cosmochimica+Acta&rft.atitle=Aerosols%3B+the+colloids+of+the+atmosphere&rft.au=Buseck%2C+Peter+R%3BSchwartz%2C+Stephen+E%3BAnonymous&rft.aulast=Buseck&rft.aufirst=Peter&rft.date=2002-08-01&rft.volume=66&rft.issue=15A&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Geochimica+et+Cosmochimica+Acta&rft.issn=00167037&rft_id=info:doi/ L2 - http://www.sciencedirect.com/science/journal/00167037 LA - English DB - GeoRef N1 - Conference title - 12th annual V. M. Goldschmidt conference N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Last updated - 2012-06-07 N1 - CODEN - GCACAK N1 - SubjectsTermNotLitGenreText - aerosols; atmosphere; characterization; clastic sediments; climate change; clouds; colloidal materials; dust; ecology; electron diffraction data; experimental studies; geochemistry; human activity; human ecology; nitrate ion; organic compounds; particulate materials; public health; sediments; solar radiation; spectra; sulfate ion; sulfur; suspended materials; TEM data; X-ray spectra ER - TY - JOUR T1 - Organic nitrogen in geomacromolecules: insights on speciation and transformation with K-edge XANES spectroscopy. AN - 71939869; 12141481 AB - Organic nitrogen incorporated into geomacromolecules (e.g., humic substances, kerogen) represents a major reservoir of nitrogen on the earth's surface, accounting for more than 90% of the total nitrogen in soils, sediments, and aquatic environments. Its primary source is biochemical nitrogen from dead plant and animal residues (predominantly proteinaceous substances), which undergo a complex series of transformations, mediated by microbes and abiotic processes, ultimately resulting in the incorporation of the nonmineralized fraction into geomacromolecules. Simultaneously,the biochemical N is thought to be extensively altered structurally, forming more stable structures (such as heterocyclic forms), although the type of changes in chemical speciation, their timing, and mechanisms are not clear. It is important to have this knowledge because the type of N formed influences not only its reactivity and fate (e.g., the release of bioavailable N in soils) but also the physical and chemical characteristics of the associated macromolecular organic matter. We used nitrogen K-edge XANES spectroscopy (a selective, sensitive, and nondestructive method) to gain new insights into the speciation of this macromolecular nitrogen. Our results verified amide N as being the dominant type in humic substances and sediments but revealed that pyridinic N also is a significant component of the total N (approximately 20-30%), with a subfraction consisting of its oxidized derivatives. An unidentified form of highly oxidized N was present mainly in sediments. While amide N represents residues of original biochemical molecules, pyridinic N probably is generated abiotically. Our results imply that the abiotic formation of pyridinic N sets in during the early stages of organic matter transformations thereby stabilizing organic N, although such processes generating heterocyclic structures may continue much longer. JF - Environmental science & technology AU - Vairavamurthy, A AU - Wang, S AD - Department of Energy Sciences and Technology, Brookhaven National Laboratory, Upton, New York 11973, USA. vmurthy@bnl.gov Y1 - 2002/07/15/ PY - 2002 DA - 2002 Jul 15 SP - 3050 EP - 3056 VL - 36 IS - 14 SN - 0013-936X, 0013-936X KW - Pyridines KW - 0 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Environmental Monitoring KW - Spectrum Analysis KW - Biotransformation KW - Nitrogen -- chemistry KW - Geologic Sediments -- chemistry KW - Pyridines -- chemistry KW - Nitrogen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71939869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Organic+nitrogen+in+geomacromolecules%3A+insights+on+speciation+and+transformation+with+K-edge+XANES+spectroscopy.&rft.au=Vairavamurthy%2C+A%3BWang%2C+S&rft.aulast=Vairavamurthy&rft.aufirst=A&rft.date=2002-07-15&rft.volume=36&rft.issue=14&rft.spage=3050&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-01-08 N1 - Date created - 2002-07-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Bistranded Oxidized Purine Damage Clusters: Induced in DNA by Long-Wavelength Ultraviolet (290-400 nm) Radiation? AN - 18704343; 5594536 AB - Bistranded clustered DNA damages involving oxidized bases, abasic sites, and strand breaks are produced by ionizing radiation and radiomimetic drugs, but it was not known whether they can be formed by other agents, e.g., nonionizing radiation. UV radiation produces clusters of cyclobutyl pyrimidine dimers, photoproducts that occur individually in high yield. Since long-wavelength UV (290-400 nm) radiation induces oxidized bases, abasic sites, and strand breaks at low yields, we tested whether it also produces clusters containing these lesions. We exposed supercoiled pUC18 DNA to UV radiation with wavelengths of >290 nm (UVB plus UVA radiation), and assessed the induction of bistranded clustered oxidized purine and abasic clusters, as recognized by Escherichia coli Fpg protein and E. coli Nfo protein (endonuclease IV), respectively, as well as double-strand breaks. These three classes of bistranded clusters were detected, albeit at very low yields (37 Fpg-OxyPurine clusters Gbp super(-1) kJ super(-1) m super(2), 8.1 double-strand breaks Gbp super(-1) kJ super(-1) m super(2), and 3.4 Nfo-abasic clusters Gbp super(-1) kJ super(-1) m super(2)). Thus, these bistranded OxyPurine clusters, abasic clusters, and double-strand breaks are not uniquely induced by ionizing radiation and radiomimetic drugs, but their level of production by UVB and UVA radiation is negligible compared to the levels of frequent photoproducts such as pyrimidine dimers. JF - Biochemistry (Washington) AU - Song, J M AU - Milligan, J R AU - Sutherland, B M AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA Y1 - 2002/07/09/ PY - 2002 DA - 2002 Jul 09 SP - 8683 EP - 8688 VL - 41 IS - 27 SN - 0006-2960, 0006-2960 KW - Fpg protein KW - Nfo protein KW - purines KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - N 14630:Chemical reactions & interactions, including effects of radiation KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18704343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Bistranded+Oxidized+Purine+Damage+Clusters%3A+Induced+in+DNA+by+Long-Wavelength+Ultraviolet+%28290-400+nm%29+Radiation%3F&rft.au=Song%2C+J+M%3BMilligan%2C+J+R%3BSutherland%2C+B+M&rft.aulast=Song&rft.aufirst=J&rft.date=2002-07-09&rft.volume=41&rft.issue=27&rft.spage=8683&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi020137x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1021/bi020137x ER - TY - JOUR T1 - Effect of vehicle on brain uptake of [11C]toluene. AN - 71866020; 12088732 AB - With the goal of investigating the pharmacokinetics of the abused solvent, toluene we have adapted the rapid coupling of methyl iodide with tributylphenylstannane mediated by palladium(0) complex to the synthesis of no-carrier-added [11C]toluene starting with 11CH(3)I. Two methods for purification and formulation of the tracer were developed. The first one yielded [11C]toluene dissolved in dimethylacetamide/saline solution, for the second one we adapted supercritical fluid technology where the tracer was purified using and conventional C(18) HPLC column and pure supercritical CO(2) fluid as a mobile phase operating at 2000 psi. Formulation of the tracer in cyclodextrin resulted in a significantly higher integrated uptake and distribution volume values. Additionally, we observed higher uptake and slower clearance of 11C-toluene in white matter, consistent with higher lipid content and neurotoxicological evidence indicating restricted and diffuse white matter changes in toluene abusers. This trend was observed when either DMA or cyclodextrin was used as a vehicle. It appears then, that the choice of a vehicle affected only the degree of bioavailability, but not the regional brain pharmacokinetics. Finally, we demonstrated the effect of a decreased percent difference between DV values for the studies performed on the same day, that is, test/retest variability was lower for all brain regions in beta-cyclodextrin experiments. Present results clearly demonstrate that the choice of a vehicle has a significant effect on tracer uptake and should be considered as a potential factor contributing to the pharmacokinetic measurements. JF - Nuclear medicine and biology AU - Gerasimov, Madina R AU - Logan, Jean AU - Ferrieri, Richard A AU - Muller, Ryan D AU - Alexoff, David AU - Dewey, Stephen L AD - Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11973, USA. madina@bnl.gov Y1 - 2002/07// PY - 2002 DA - July 2002 SP - 607 EP - 612 VL - 29 IS - 5 SN - 0969-8051, 0969-8051 KW - Acetamides KW - 0 KW - Carbon Radioisotopes KW - Cyclodextrins KW - Pharmaceutical Vehicles KW - Radiopharmaceuticals KW - Toluene KW - 3FPU23BG52 KW - dimethylacetamide KW - JCV5VDB3HY KW - Index Medicus KW - Pharmaceutical Vehicles -- pharmacology KW - Papio KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Acetamides -- pharmacology KW - Radiopharmaceuticals -- chemical synthesis KW - Tissue Distribution KW - Female KW - Radionuclide Imaging KW - Carbon Radioisotopes -- pharmacokinetics KW - Cyclodextrins -- pharmacology KW - Toluene -- pharmacokinetics KW - Isotope Labeling -- methods KW - Brain -- metabolism KW - Carbon Radioisotopes -- isolation & purification KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71866020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+and+biology&rft.atitle=Effect+of+vehicle+on+brain+uptake+of+%5B11C%5Dtoluene.&rft.au=Gerasimov%2C+Madina+R%3BLogan%2C+Jean%3BFerrieri%2C+Richard+A%3BMuller%2C+Ryan+D%3BAlexoff%2C+David%3BDewey%2C+Stephen+L&rft.aulast=Gerasimov&rft.aufirst=Madina&rft.date=2002-07-01&rft.volume=29&rft.issue=5&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+and+biology&rft.issn=09698051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-02-10 N1 - Date created - 2002-06-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. AN - 71752553; 12036507 AB - This study aims to determine possible persistent abnormalities in regional cerebral blood flow (relative rCBF) and cognitive function in abstinent methamphetamine (METH) users. Twenty METH-dependent subjects (abstinent for 8+/-2 months) and 20 age- and gender-matched controls were evaluated with perfusion magnetic resonance imaging (pMRI) and neuropsychological tests. METH users showed decreased relative rCBF bilaterally in putamen/insular cortices (right: -12%; left: -10%) and the right lateral parietal brain region (-11%), but increased relative rCBF bilaterally in the left temporoparietal white matter (+13%), the left occipital brain region: (+10%) and the right posterior parietal region (+24%). Interaction effects were observed between METH and gender in the right occipital cortex and a midline brain region; female METH users showed increased relative rCBF (+15% both regions) whereas the male METH users had decreased relative rCBF (-10% and -18%, respectively). METH users performed within normal ranges on standard neuropsychological tests; however, they were slower on several tasks on the California Computerized Assessment Package (CalCAP), especially tasks that required working memory. These findings suggest that METH abuse is associated with persistent physiologic changes in the brain, and these changes are accompanied by slower reaction times on computerized measures of cognitive function. JF - Psychiatry research AU - Chang, Linda AU - Ernst, Thomas AU - Speck, Oliver AU - Patel, Hetal AU - DeSilva, Menaka AU - Leonido-Yee, Maria AU - Miller, Eric N AD - Medical Department, Brookhaven National Laboratory, Building 490, Upton, NY, 11973-5000, USA. changl@bnl.gov Y1 - 2002/06/15/ PY - 2002 DA - 2002 Jun 15 SP - 65 EP - 79 VL - 114 IS - 2 SN - 0165-1781, 0165-1781 KW - Contrast Media KW - 0 KW - Heterocyclic Compounds KW - Organometallic Compounds KW - gadoteridol KW - 0199MV609F KW - Methamphetamine KW - 44RAL3456C KW - Gadolinium KW - AU0V1LM3JT KW - Index Medicus KW - Reaction Time -- drug effects KW - Reference Values KW - Humans KW - Adult KW - Regional Blood Flow -- drug effects KW - Image Enhancement KW - Male KW - Female KW - Substance-Related Disorders -- physiopathology KW - Echo-Planar Imaging KW - Substance-Related Disorders -- diagnosis KW - Substance Withdrawal Syndrome -- physiopathology KW - Substance Withdrawal Syndrome -- diagnosis KW - Methamphetamine -- adverse effects KW - Brain -- drug effects KW - Brain -- blood supply KW - Diagnosis, Computer-Assisted KW - Substance Withdrawal Syndrome -- psychology KW - Substance-Related Disorders -- rehabilitation KW - Neuropsychological Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71752553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Perfusion+MRI+and+computerized+cognitive+test+abnormalities+in+abstinent+methamphetamine+users.&rft.au=Chang%2C+Linda%3BErnst%2C+Thomas%3BSpeck%2C+Oliver%3BPatel%2C+Hetal%3BDeSilva%2C+Menaka%3BLeonido-Yee%2C+Maria%3BMiller%2C+Eric+N&rft.aulast=Chang&rft.aufirst=Linda&rft.date=2002-06-15&rft.volume=114&rft.issue=2&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Psychiatry+research&rft.issn=01651781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-07-31 N1 - Date created - 2002-05-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Clustered DNA damages induced by x rays in human cells. AN - 71690707; 12005538 AB - Although DNA DSBs are known to be important in producing the damaging effects of ionizing radiation in cells, bistranded clustered DNA damages-two or more oxidized bases, abasic sites or strand breaks on opposing DNA strands within a few helical turns-are postulated to be difficult to repair and thus to be critical radiation-induced lesions. Gamma rays can induce clustered damages in DNA in solution, and high-energy iron ions produce DSBs and oxidized pyrimidine clusters in human cells, but it was not known whether sparsely ionizing radiation can produce clustered damages in mammalian cells. We show here that X rays induce abasic clusters, oxidized pyrimidine clusters, and oxidized purine clusters in DNA in human cells. Non-DSB clustered damages comprise about 70% of the complex lesions produced in cells. The relative levels of specific cluster classes depend on the environment of the DNA. JF - Radiation research AU - Sutherland, Betsy M AU - Bennett, Paula V AU - Sutherland, John C AU - Laval, Jacques AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. bms@bnl.gov Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 611 EP - 616 VL - 157 IS - 6 SN - 0033-7587, 0033-7587 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Non-programmatic KW - X-Rays KW - Humans KW - Electrophoresis, Agar Gel KW - Dose-Response Relationship, Radiation KW - Molecular Weight KW - Cell Line KW - DNA -- metabolism KW - DNA -- genetics KW - DNA Damage -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71690707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Clustered+DNA+damages+induced+by+x+rays+in+human+cells.&rft.au=Sutherland%2C+Betsy+M%3BBennett%2C+Paula+V%3BSutherland%2C+John+C%3BLaval%2C+Jacques&rft.aulast=Sutherland&rft.aufirst=Betsy&rft.date=2002-06-01&rft.volume=157&rft.issue=6&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-19 N1 - Date created - 2002-05-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cesium adsorption on clay minerals; an EXAFS spectroscopic investigation AN - 51839199; 2004-044989 JF - Environmental Science & Technology, ES & T AU - Bostick, Benjamin C AU - Vairavamurthy, Murthy A AU - Karthikeyan, K G AU - Chorover, Jon Y1 - 2002/06// PY - 2002 DA - June 2002 SP - 2670 EP - 2676 PB - American Chemical Society, Washington, DC VL - 36 IS - 12 SN - 0013-936X, 0013-936X KW - silicates KW - isotopes KW - complexing KW - ground water KW - laboratory studies KW - radioactive isotopes KW - cesium KW - sediments KW - X-ray analysis KW - montmorillonite KW - soils KW - toxic materials KW - experimental studies KW - monitoring KW - underground storage KW - alkali metals KW - pollution KW - migration of elements KW - kaolinite KW - adsorption KW - clay minerals KW - Cs-137 KW - metals KW - X-ray spectroscopy KW - underground installations KW - sheet silicates KW - vermiculite KW - spectroscopy KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51839199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.atitle=Cesium+adsorption+on+clay+minerals%3B+an+EXAFS+spectroscopic+investigation&rft.au=Bostick%2C+Benjamin+C%3BVairavamurthy%2C+Murthy+A%3BKarthikeyan%2C+K+G%3BChorover%2C+Jon&rft.aulast=Bostick&rft.aufirst=Benjamin&rft.date=2002-06-01&rft.volume=36&rft.issue=12&rft.spage=2670&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology%2C+ES+%26+T&rft.issn=0013936X&rft_id=info:doi/ L2 - http://pubs.acs.org/journals/esthag/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2012-06-07 N1 - CODEN - ESTHAG N1 - SubjectsTermNotLitGenreText - adsorption; alkali metals; cesium; clay minerals; complexing; Cs-137; experimental studies; ground water; isotopes; kaolinite; laboratory studies; metals; migration of elements; monitoring; montmorillonite; pollution; radioactive isotopes; sediments; sheet silicates; silicates; soils; spectroscopy; toxic materials; underground installations; underground storage; vermiculite; X-ray analysis; X-ray spectroscopy ER - TY - JOUR T1 - Plant and Environment Interactions: Uptake of Cesium-137 and Strontium-90 from Contaminated Soil by Three Plant Species; Application to Phytoremediation AN - 20983562; 5411170 AB - A field test was conducted to determine the ability of three plant species to extract super(137)Cs and super(90)Sr from contaminated soil. Redroot pigweed (Amaranthus retroflexus L.), Indian mustard [Brassica juncea (L.) Czern.], and tepary bean (Phaseolus acutifolius A. Gray) were planted in a series of spatially randomized cells in soil that was contaminated in the 1950s and 1960s. We examined the potential for phytoextraction of super(90)Sr and super(137)Cs by these three species. Concentration ratios (CR) for super(137)Cs for redroot pigweed, Indian mustard, and tepary bean were 2.58, 0.46, and 0.17, respectively. For super(90)Sr they were substantially higher: 6.5, 8.2, and 15.2, respectively. The greatest accumulation of both radionuclides was obtained with redroot pigweed, even though its CR for super(90)Sr was the lowest, because of its relatively large biomass. There was a linear relationship between the super(137)Cs concentration in plants and its concentration in soil only for redroot pigweed. Uptake of super(90)Sr exhibits no relationship to super(90)Sr concentrations in the soil. Estimates of time required for removal of 50% of the two contaminants, assuming two crops of redroot pigweed per year, are 7 yr for super(90)Sr and 18 yr for super(137)Cs. JF - Journal of Environmental Quality AU - Fuhrmann, M AU - Lasat, M M AU - Ebbs, S D AU - Kochian, LV AU - Cornish, J AD - Environmental and Waste Technology Group, Brookhaven National Lab., Building 830, Upton, NY 11973-5000, USA, fuhrmann@bnl.gov Y1 - 2002/06// PY - 2002 DA - Jun 2002 SP - 904 EP - 909 VL - 31 IS - 3 SN - 0047-2425, 0047-2425 KW - Tepiary bean KW - Biotechnology and Bioengineering Abstracts; Pollution Abstracts KW - Cesium KW - Amaranthus retroflexus KW - Soil contamination KW - Biomass KW - Beans KW - Crops KW - Phaseolus acutifolius KW - Brassica juncea KW - Soil pollution KW - Soil KW - Phytoremediation KW - Plants KW - Radioisotopes KW - Environmental quality KW - Strontium KW - Plant extracts KW - Contaminants KW - phytoremediation KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 8000:RADIATION KW - P 5000:LAND POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20983562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Plant+and+Environment+Interactions%3A+Uptake+of+Cesium-137+and+Strontium-90+from+Contaminated+Soil+by+Three+Plant+Species%3B+Application+to+Phytoremediation&rft.au=Fuhrmann%2C+M%3BLasat%2C+M+M%3BEbbs%2C+S+D%3BKochian%2C+LV%3BCornish%2C+J&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=2002-06-01&rft.volume=31&rft.issue=3&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-10-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Soil; Soil pollution; Radioisotopes; Environmental quality; Strontium; Plant extracts; Biomass; phytoremediation; Contaminants; Crops; Beans; Cesium; Phytoremediation; Plants; Soil contamination; Brassica juncea; Amaranthus retroflexus; Phaseolus acutifolius ER - TY - JOUR T1 - Uptake of cesium-137 and strontium-90 from contaminated soil by three plant species; application to phytoremediation. AN - 71706776; 12026094 AB - A field test was conducted to determine the ability of three plant species to extract 137Cs and 90Sr from contaminated soil. Redroot pigweed (Amaranthus retroflexus L.), Indian mustard [Brassica juncea (L.) Czern.], and tepary bean (Phaseolus acutifolius A. Gray) were planted in a series of spatially randomized cells in soil that was contaminated in the 1950s and 1960s. We examined the potential for phytoextraction of 90Sr and 137Cs by these three species. Concentration ratios (CR) for 137Cs for redroot pigweed, Indian mustard, and tepary bean were 2.58, 0.46, and 0.17, respectively. For 90Sr they were substantially higher: 6.5, 8.2, and 15.2, respectively. The greatest accumulation of both radionuclides was obtained with redroot pigweed, even though its CR for 90Sr was the lowest, because of its relatively large biomass. There was a linear relationship between the 137Cs concentration in plants and its concentration in soil only for redroot pigweed. Uptake of 90Sr exhibits no relationship to 90Sr concentrations in the soil. Estimates of time required for removal of 50% of the two contaminants, assuming two crops of redroot pigweed per year, are 7 yr for 90Sr and 18 yr for 137Cs. JF - Journal of environmental quality AU - Fuhrmann, Mark AU - Lasat, Mitch M AU - Ebbs, Stephen D AU - Kochian, Leon V AU - Cornish, Jay AD - Environmental and Waste Technology Group, Brookhaven National Lab., Upton, NY 11973-5000, USA. fuhrmann@bnl.gov PY - 2002 SP - 904 EP - 909 VL - 31 IS - 3 SN - 0047-2425, 0047-2425 KW - Cesium Radioisotopes KW - 0 KW - Soil Pollutants, Radioactive KW - Strontium Radioisotopes KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Amaranthus -- metabolism KW - Phaseolus -- metabolism KW - Brassica -- metabolism KW - Conservation of Natural Resources KW - Soil Pollutants, Radioactive -- pharmacology KW - Strontium Radioisotopes -- pharmacology KW - Cesium Radioisotopes -- pharmacology KW - Soil Pollutants, Radioactive -- administration & dosage KW - Cesium Radioisotopes -- administration & dosage KW - Strontium Radioisotopes -- administration & dosage KW - Angiosperms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71706776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+quality&rft.atitle=Uptake+of+cesium-137+and+strontium-90+from+contaminated+soil+by+three+plant+species%3B+application+to+phytoremediation.&rft.au=Fuhrmann%2C+Mark%3BLasat%2C+Mitch+M%3BEbbs%2C+Stephen+D%3BKochian%2C+Leon+V%3BCornish%2C+Jay&rft.aulast=Fuhrmann&rft.aufirst=Mark&rft.date=2002-05-01&rft.volume=31&rft.issue=3&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+quality&rft.issn=00472425&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-11-07 N1 - Date created - 2002-05-23 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Size effect of hematite and corundum inclusions on the efflorescence relative humidities of aqueous ammonium nitrate particles AN - 52024965; 2003-010572 JF - Journal of Geophysical Research AU - Han, Jeong-Ho AU - Hung, Hui-Ming AU - Martin, Scot T Y1 - 2002/05// PY - 2002 DA - May 2002 SP - 10 PB - American Geophysical Union, Washington, DC VL - 107 IS - D9-10 SN - 0148-0227, 0148-0227 KW - silicates KW - sorption KW - aqueous solutions KW - corundum KW - infrared spectra KW - chemical reactions KW - hematite KW - sediments KW - orthosilicates KW - mullite KW - oxides KW - spectra KW - ammonium nitrate KW - clastic sediments KW - grain size KW - nitrates KW - atmosphere KW - nesosilicates KW - humidity KW - efflorescence KW - saturation KW - dust KW - aerosols KW - particles KW - minerals KW - 02C:Geochemistry of rocks, soils, and sediments UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52024965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Geophysical+Research&rft.atitle=Size+effect+of+hematite+and+corundum+inclusions+on+the+efflorescence+relative+humidities+of+aqueous+ammonium+nitrate+particles&rft.au=Han%2C+Jeong-Ho%3BHung%2C+Hui-Ming%3BMartin%2C+Scot+T&rft.aulast=Han&rft.aufirst=Jeong-Ho&rft.date=2002-05-01&rft.volume=107&rft.issue=D9-10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Geophysical+Research&rft.issn=01480227&rft_id=info:doi/10.1029%2F2001JD001054 L2 - http://www.agu.org/journals/jgr/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2003-01-01 N1 - Number of references - 39 N1 - PubXState - DC N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aerosols; ammonium nitrate; aqueous solutions; atmosphere; chemical reactions; clastic sediments; corundum; dust; efflorescence; grain size; hematite; humidity; infrared spectra; minerals; mullite; nesosilicates; nitrates; orthosilicates; oxides; particles; saturation; sediments; silicates; sorption; spectra DO - http://dx.doi.org/10.1029/2001JD001054 ER - TY - JOUR T1 - Photodegradation of a Ternary Iron(III)-Uranium(VI)-Citric Acid Complex AN - 16142661; 5467642 AB - The mechanisms of photodegradation of binary iron- and uranium-citrate and ternary iron-uranium-citrate complexes were elucidated. Citric acid degradation products were identified by HPLC and GC, and the metal precipitates were identified by XRD and EXAFS. Photodegradation of a binuclear iron-citrate complex occurred as a result of two one-electron oxidations of citric acid with the formation of 3-oxoglutarate and two ferrous ions. The ferrous ions were reoxidized by a photo-Fenton reaction, resulting in the precipitation of iron as two-line ferrihydrite Fe(OH) sub(3). The citric acid in the uranium-citrate complex underwent a two-electron oxidation to acetoacetate with the concomitant reduction of U(VI) to U(IV). The U(IV) was subsequently photooxidized in the presence of dioxygen with precipitation of uranium as the mineral schoepite (UO sub(3) times 2H sub(2)O). A two-step electron reduction of two ferric ions to two ferrous ions was the primary mechanism for photodegradation of the ternary iron-uranium-citrate complex with oxidation of citric acid to 3-oxoglutarate; reduction of uranium was not observed. The iron precipitated as ferrihydrite and the uranyl ion as a uranyl hydroxide species. These results show the potential application of photochemical treatment of wastewater and decontamination solutions containing binary and ternary iron- and uranium-citrate complexes. JF - Environmental Science & Technology AU - Dodge, C J AU - Francis, A J AD - Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973, USA, dodge1@bnl.gov Y1 - 2002/05/01/ PY - 2002 DA - 2002 May 01 SP - 2094 EP - 2100 VL - 36 IS - 9 SN - 0013-936X, 0013-936X KW - citric acid KW - Pollution Abstracts KW - Photochemistry KW - Photodegradation KW - Uranium KW - Oxidation KW - Iron KW - Wastewater treatment KW - P 3000:SEWAGE & WASTEWATER TREATMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16142661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Photodegradation+of+a+Ternary+Iron%28III%29-Uranium%28VI%29-Citric+Acid+Complex&rft.au=Dodge%2C+C+J%3BFrancis%2C+A+J&rft.aulast=Dodge&rft.aufirst=C&rft.date=2002-05-01&rft.volume=36&rft.issue=9&rft.spage=2094&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-11-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Photochemistry; Photodegradation; Uranium; Oxidation; Wastewater treatment; Iron ER - TY - JOUR T1 - Shedding light on proteins, nucleic acids, cells, humans and fish. AN - 71532864; 11906839 AB - I was trained as a physicist in graduate school. Hence, when I decided to go into the field of biophysics, it was natural that I concentrated on the effects of light on relatively simple biological systems, such as proteins. The wavelengths absorbed by the amino acid subunits of proteins are in the ultraviolet (UV). The wavelengths that affect the biological activities, the action spectra, also are in the UV, but are not necessarily parallel to the absorption spectra. Understanding these differences led me to investigate the action spectra for affecting nucleic acids, and the effects of UV on viruses and cells. The latter studies led me to the discovery of the important molecular nature of the damages affecting DNA (cyclobutane pyrimidine dimers) and to the discovery of nucleotide excision repair. Individuals with the genetic disease xeroderma pigmentosum (XP) are extraordinarily sensitive to sunlight-induced skin cancer. The finding, by James Cleaver, that their skin cells were defective in DNA repair strongly suggested that DNA damage was a key step in carcinogenesis. Such information was important for estimating the wavelengths in sunlight responsible for human skin cancer and for predicting the effects of ozone depletion on the incidence of non-melanoma skin cancer. It took experiments with backcross hybrid fish to call attention to the probable role of the longer UV wavelengths not absorbed by DNA in the induction of melanoma. These reflections trace the biophysicist's path from molecules to melanoma. JF - Mutation research AU - Setlow, Richard B AD - Biology Department, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA. setlow@bnl.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 1 EP - 14 VL - 511 IS - 1 SN - 0027-5107, 0027-5107 KW - PrPSc Proteins KW - 0 KW - Proteins KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Space life sciences KW - Setlow KW - NASA Discipline Radiation Health KW - Non-NASA Center KW - United States KW - Animals KW - History, 20th Century KW - PrPSc Proteins -- radiation effects KW - Melanoma -- history KW - Melanoma -- etiology KW - Humans KW - Fishes KW - Cells, Cultured -- radiation effects KW - Xeroderma Pigmentosum -- genetics KW - Poecilia -- physiology KW - Xeroderma Pigmentosum -- history KW - Ultraviolet Rays -- history KW - Proteins -- history KW - DNA -- radiation effects KW - Proteins -- radiation effects KW - DNA -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71532864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Shedding+light+on+proteins%2C+nucleic+acids%2C+cells%2C+humans+and+fish.&rft.au=Setlow%2C+Richard+B&rft.aulast=Setlow&rft.aufirst=Richard&rft.date=2002-03-01&rft.volume=511&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-19 N1 - Date created - 2002-03-21 N1 - Date revised - 2017-02-17 N1 - People - Setlow N1 - Last updated - 2017-02-22 N1 - SubjectsTermNotLitGenreText - Setlow ER - TY - JOUR T1 - Jolly SAD. AN - 71466174; 11856836 AB - Examples of phasing macromolecular crystal structures based on single-wavelength anomalous dispersion (SAD) show that this approach is more powerful and may have more general application in structural biology than was anticipated. Better data-collection facilities and cryogenic techniques, coupled with powerful programs for data processing, phasing, density modification and automatic model building, means that the SAD approach may gain wide popularity owing to its simplicity, less stringent wavelength requirements and faster data collection and phasing than the multi-wavelength (MAD) approach. It can be performed at any wavelength where anomalous scattering can be observed, in many cases using laboratory X-ray sources. JF - Acta crystallographica. Section D, Biological crystallography AU - Dauter, Zbigniew AU - Dauter, Miroslawa AU - Dodson, Eleanor AD - Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, NCI, Brookhaven National Laboratory, Building 725A-X9, Upton, NY 11973, USA. dauter@bnl.gov Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 494 EP - 506 VL - 58 SN - 0907-4449, 0907-4449 KW - Ferredoxins KW - 0 KW - Insulin KW - Lithium Compounds KW - Metals, Heavy KW - Oligopeptides KW - Rubredoxins KW - Sulfates KW - Phosphorus KW - 27YLU75U4W KW - Manganese KW - 42Z2K6ZL8P KW - Chlorine KW - 4R7X1O2820 KW - Sulfur KW - 70FD1KFU70 KW - DNA KW - 9007-49-2 KW - lithium sulfate KW - 919XA137JK KW - Selenomethionine KW - 964MRK2PEL KW - Iron KW - E1UOL152H7 KW - Thiolester Hydrolases KW - EC 3.1.2.- KW - Muramidase KW - EC 3.2.1.17 KW - Carboxypeptidases KW - EC 3.4.- KW - serine carboxypeptidase KW - EC 3.4.16.5 KW - Subtilisin KW - EC 3.4.21.62 KW - Pyrophosphatases KW - EC 3.6.1.- KW - dUTP pyrophosphatase KW - EC 3.6.1.23 KW - Aldose-Ketose Isomerases KW - EC 5.3.1.- KW - xylose isomerase KW - EC 5.3.1.5 KW - Zinc KW - J41CSQ7QDS KW - Bromine KW - SBV4XY874G KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calcium -- chemistry KW - Oligopeptides -- chemistry KW - Sulfur -- chemistry KW - Zinc -- chemistry KW - Molecular Weight KW - Phosphorus -- chemistry KW - Bromine -- chemistry KW - Carboxypeptidases -- chemistry KW - DNA -- chemistry KW - Protein Conformation KW - Pyrophosphatases -- chemistry KW - Selenomethionine -- chemistry KW - Aldose-Ketose Isomerases -- chemistry KW - Models, Molecular KW - Subtilisin -- chemistry KW - Lithium Compounds -- chemistry KW - Iron -- chemistry KW - Insulin -- chemistry KW - Ferredoxins -- chemistry KW - Sulfates -- chemistry KW - Muramidase -- chemistry KW - Thiolester Hydrolases -- chemistry KW - Manganese -- chemistry KW - Rubredoxins -- chemistry KW - Chlorine -- chemistry KW - Models, Chemical KW - Metals, Heavy -- chemistry KW - Crystallography, X-Ray -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71466174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Jolly+SAD.&rft.au=Dauter%2C+Zbigniew%3BDauter%2C+Miroslawa%3BDodson%2C+Eleanor&rft.aulast=Dauter&rft.aufirst=Zbigniew&rft.date=2002-03-01&rft.volume=58&rft.issue=&rft.spage=494&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-06-18 N1 - Date created - 2002-03-07 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Monoclinic nearly stoichiometric wustite at low temperatures AN - 51875565; 2004-020573 AB - The crystallographic and magnetic structures of Fe (sub 0.99) O at 10 K have been determined by high-resolution neutron powder diffraction. Fe (sub 0.99) O is found to be monoclinic, space group C2/m, with unit-cell dimensions a = 5.2615(1), b = 3.0334(1), c = 3.0602 (1) Aa, and beta = 124.649(2) degrees . The Fe-O distances in the distorted FeO (sub 6) octahedron are 2.154 AaX4 and 2.165 AaX2. The magnetic unit cell is obtained by doubling one of the crystallographic axes, a (magn) = a (sub m) , b (magn) = b (sub m) , and c (magn) = 2c (sub m) . The refined magnetic components at 8 K are M (sub x) = 2.7(1) mu B, M (sub y) = -0.9(2) mu B, and M (sub z) = 4.77(2)mu B, with resultant M = 4.03(2) mu B. JF - American Mineralogist AU - Fjellvag, Helmer AU - Hauback, Bjorn C AU - Vogt, Tom AU - Stolen, Svein Y1 - 2002/03// PY - 2002 DA - March 2002 SP - 347 EP - 349 PB - Mineralogical Society of America, Washington, DC VL - 87 IS - 2-3 SN - 0003-004X, 0003-004X KW - crystal systems KW - low temperature KW - unit cell KW - oxides KW - monoclinic system KW - crystallography KW - wustite KW - stoichiometry KW - temperature KW - order-disorder KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51875565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Mineralogist&rft.atitle=Monoclinic+nearly+stoichiometric+wustite+at+low+temperatures&rft.au=Fjellvag%2C+Helmer%3BHauback%2C+Bjorn+C%3BVogt%2C+Tom%3BStolen%2C+Svein&rft.aulast=Fjellvag&rft.aufirst=Helmer&rft.date=2002-03-01&rft.volume=87&rft.issue=2-3&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=American+Mineralogist&rft.issn=0003004X&rft_id=info:doi/ L2 - http://ammin.geoscienceworld.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2004-01-01 N1 - Number of references - 17 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - AMMIAY N1 - SubjectsTermNotLitGenreText - crystal systems; crystallography; low temperature; monoclinic system; order-disorder; oxides; stoichiometry; temperature; unit cell; wustite ER - TY - JOUR T1 - Toluene inhalation produces regionally specific changes in extracellular dopamine. AN - 71456049; 11841896 AB - The aim of the present study was to investigate the effect of toluene inhalation on dopaminergic transmission in two distinct brain areas presumably involved in mediating the reward processes important for toluene abuse. Extracellular dopamine (DA) levels were measured in prefrontal cortex (PFC) and nucleus accumbens (NACC) of freely moving rats using in vivo microdialysis. Inhalation of a behaviorally relevant concentration of toluene (3000 ppm) produced a significant increase in the PFC but not in the NACC. However, the odorant isoamyl acetate, increased PFC DA levels by only 37%, significantly less than the 96% increase observed following toluene exposure. When toluene inhalation was combined with cocaine administration (20 mg/kg i.p.), the response to the combined challenge was not different from the response to toluene alone in the PFC. However, the combination of these two drugs produced a supradditive response of 802% in the NACC, compared with the 450% increase observed following cocaine alone. Recent reports indicate that toluene influences the function of several ionotropic receptors in a subunit specific manner. As further evidence of specific effects, our results indicate regionally specific changes in dopaminergic transmission following toluene exposure. JF - Drug and alcohol dependence AU - Gerasimov, Madina R AU - Schiffer, Wynne K AU - Marstellar, Douglas AU - Ferrieri, Richard AU - Alexoff, David AU - Dewey, Stephen L AD - Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973, USA. madina@bnl.gov Y1 - 2002/02/01/ PY - 2002 DA - 2002 Feb 01 SP - 243 EP - 251 VL - 65 IS - 3 SN - 0376-8716, 0376-8716 KW - Dopamine Uptake Inhibitors KW - 0 KW - Pentanols KW - Toluene KW - 3FPU23BG52 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - isoamyl acetate KW - Z135787824 KW - Index Medicus KW - Rats KW - Pentanols -- pharmacology KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Drug Synergism KW - Cocaine -- pharmacology KW - Administration, Inhalation KW - Dopamine Uptake Inhibitors -- pharmacology KW - Toluene -- pharmacology KW - Prefrontal Cortex -- metabolism KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Prefrontal Cortex -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71456049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Toluene+inhalation+produces+regionally+specific+changes+in+extracellular+dopamine.&rft.au=Gerasimov%2C+Madina+R%3BSchiffer%2C+Wynne+K%3BMarstellar%2C+Douglas%3BFerrieri%2C+Richard%3BAlexoff%2C+David%3BDewey%2C+Stephen+L&rft.aulast=Gerasimov&rft.aufirst=Madina&rft.date=2002-02-01&rft.volume=65&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-04-23 N1 - Date created - 2002-02-13 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Reactive oxygen species in cell responses to toxic agents AN - 18446406; 5419095 AB - This review first summarizes experimental data on biological effects of different concentrations of ROS in mammalian cells and on their potential role in modifying cell responses to toxic agents. It then attempts to link the role of steadily produced metabolic ROS at various concentrations in mammalian cells to that of environmentally derived ROS bursts from exposure to ionizing radiation. The ROS from both sources are known to both cause biological damage and change cellular signaling, depending on their concentration at a given time. At low concentrations signaling effects of ROS appear to protect cellular survival and dominate over damage, and the reverse occurs at high ROS concentrations. Background radiation generates suprabasal ROS bursts along charged particle tracks several times a year in each nanogram of tissue, i.e., average mass of a mammalian cell. For instance, a burst of about 200 ROS occurs within less than a microsecond from low-LET irradiation such as X-rays along the track of a Compton electron (about 6 keV, ranging about 1 mu m). One such track per nanogram tissue gives about 1 mGy to this mass. The number of instantaneous ROS per burst along the track of a 4-meV alpha -particle in 1 ng tissue reaches some 70 000. The sizes, types and sites of these bursts, and the time intervals between them directly in and around cells appear essential for understanding low-dose and low dose-rate effects on top of effects from endogenous ROS. At background and low-dose radiation exposure, a major role of ROS bursts along particle tracks focuses on ROS-induced apoptosis of damage-carrying cells, and also on prevention and removal of DNA damage from endogenous sources by way of temporarily protective, i.e., adaptive, cellular responses. A conclusion is to consider low-dose radiation exposure as a provider of physiological mechanisms for tissue homoeostasis. JF - Human & Experimental Toxicology AU - Feinendegen, LE AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11073, USA, feinendegen@gmx.net Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 85 EP - 90 VL - 21 IS - 2 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - X 24210:Radiation & radioactive materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18446406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Reactive+oxygen+species+in+cell+responses+to+toxic+agents&rft.au=Feinendegen%2C+LE&rft.aulast=Feinendegen&rft.aufirst=LE&rft.date=2002-02-01&rft.volume=21&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Retrieval of aerosol properties from moments of the particle size distribution for kernels involving the step function: Cloud droplet activation AN - 18293315; 5347211 AB - Aerosol properties such as the number of particles that activate to form cloud drops and the mass contained within specified size ranges (as in the PM 2.5 and PM 10 regulatory standards) require integration over only part of the full size range of the particle distribution function (PDF) and may be formally expressed as integrals over kernels involving the Heaviside step function. Determination of these properties requires essentially that the size spectrum be partitioned into two (or more) portions, and poses a special challenge for aerosol modeling with the method of moments. To assess the ability of moment-based methods to treat kernels involving step functions, several algorithms for the estimation of aerosol properties associated with cloud activation have been evaluated. For 240 measured continental distributions employed here as test cases, the full size spectrum of the PDF was partitioned into three distinct portions based upon characteristic critical radii for activation in cumulus and stratiform clouds, and mass- and number-concentration metrics were evaluated for each portion. The first six radial moments yielded results accurate to within about 10% or better, on average, and the numbers of particles activated as cloud drops and the aerosol mass taken into cloud water were estimated to an accuracy of 5% or better. Of the moment-based approaches evaluated, the multiple isomomental distribution aerosol surrogate (MIDAS) (Wright, J. Aerosol Sci. 31 (2000) 1) technique performed best. Accurate results were also obtained with the randomized minimization search technique (RMST) (Yue et al., Geophys. Res. Lett. 24 (1997) 651; Heintzenberg et al., Appl. Opt. 20 (1981) 1308). JF - Journal of Aerosol Science AU - Wright, D L AU - Yu, Sh AU - Kasibhatla, P S AU - McGraw, R AU - Schwartz, SE AU - Saxena, V K AU - Yue, G K AD - Nicholas School of the Environment, Duke University, Durham, NC 27708, USA, dlw@bnl.gov Y1 - 2002/02// PY - 2002 DA - Feb 2002 SP - 319 EP - 337 VL - 33 IS - 2 SN - 0021-8502, 0021-8502 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Particle size KW - Aerosols KW - A 01118:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18293315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aerosol+Science&rft.atitle=Retrieval+of+aerosol+properties+from+moments+of+the+particle+size+distribution+for+kernels+involving+the+step+function%3A+Cloud+droplet+activation&rft.au=Wright%2C+D+L%3BYu%2C+Sh%3BKasibhatla%2C+P+S%3BMcGraw%2C+R%3BSchwartz%2C+SE%3BSaxena%2C+V+K%3BYue%2C+G+K&rft.aulast=Wright&rft.aufirst=D&rft.date=2002-02-01&rft.volume=33&rft.issue=2&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aerosol+Science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aerosols; Particle size ER - TY - JOUR T1 - Isolation, Characterization, and Identification of Bacteria Associated with the Zinc Hyperaccumulator Thlaspi caerulescens subsp. calaminaria AN - 744670334; 5435819 AB - We investigated bacterial populations associated with the Zn hyperaccumulator Thlaspi caerulescens subsp. calaminaria grown in a soil collected from an abandoned Zn-Pb mine and smelter in Plombieres, Belgium. The bacterial population of the nonrhizospheric soil consisted of typical soil bacteria, some exhibiting multiple heavy-metal resistance characteristics that often are associated with polluted substrates: 7.8% and 4% of the population survived in the presence of elevated levels of Zn (1 mM) and Cd (0.8 mM), respectively. For the bacterial population isolated from the rhizosphere, the comparable survival rates were 88 and 78%. This observation indicates a selective enrichment of the metal-resistant strains due to an increased availability of the metals in soils near the roots compared with nonrhizospheric soil. The endophytic inhabitants of the roots and shoots were isolated, identified, and characterized. Although similar endophytic species were isolated from both compartments, those from the rhizoplane and roots showed lower resistance to Zn and Cd than the endophytic bacteria isolated from the shoots. In addition, root endophytic bacteria had additional requirements. Contrary to the rootresiding inhabitants, the shoot represented a niche rich in metal-resistant bacteria and even seemed to contain species that were exclusively abundant there. These differences in the characteristics of the bacterial microflora associated with T. caerulescens might possibly reflect altered metal speciation in the different soils and plant compartments studied. JF - International Journal of Phytoremediation AU - Lodewyckx, C AU - Mergeay, M AU - Vangronsveld, J AU - Clijsters, H AU - Van Der Lelie, D AD - Vito, Environmental Technology, Boeretang 200, B-2400 Mol, Belgium, vdelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 101 EP - 115 PB - CRC Press LLC VL - 4 IS - 2 SN - 1522-6514, 1522-6514 KW - Microbiology Abstracts B: Bacteriology KW - Speciation KW - Heavy metals KW - Endophytes KW - Belgium KW - Rhizosphere KW - Zinc KW - Thlaspi caerulescens KW - Microflora KW - Cadmium KW - Smelters KW - Lead KW - J 02704:Enumeration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744670334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Phytoremediation&rft.atitle=Isolation%2C+Characterization%2C+and+Identification+of+Bacteria+Associated+with+the+Zinc+Hyperaccumulator+Thlaspi+caerulescens+subsp.+calaminaria&rft.au=Lodewyckx%2C+C%3BMergeay%2C+M%3BVangronsveld%2C+J%3BClijsters%2C+H%3BVan+Der+Lelie%2C+D&rft.aulast=Lodewyckx&rft.aufirst=C&rft.date=2002-01-01&rft.volume=4&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Phytoremediation&rft.issn=15226514&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Speciation; Endophytes; Heavy metals; Rhizosphere; Zinc; Microflora; Cadmium; Smelters; Lead; Thlaspi caerulescens; Belgium ER - TY - JOUR T1 - Mechanism of action of methylphenidate: insights from PET imaging studies. AN - 72873562; 12685517 AB - Methylphenidate (MPH) is the most commonly prescribed drug for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD). We have used Positron Emission Tomography (PET) to investigate the mechanism of action of MPH in the human brain. We have shown (a) that oral MPH reaches peak concentration in the brain 60-90 minutes after its administration, (b) that therapeutic doses of MPH block more than 50% of the dopamine transporters (DAT), and (c) that of the two enantiomers that compose MPH, it is d-threo-methylphenidate (d-MPH) and not l-threo-methylphenidate (l-MPH) that binds to the DAT. We have also shown that therapeutic doses of MPH significantly enhance extracellular dopamine (DA) in the basal ganglia, which is an effect that appears to be modulated by the rate of DA release and that is affected by age (older subjects show less effect). Thus, we postulate (a) that MPH's therapeutic effects are in part due to amplification of DA signals, (b) that variability in responses is in part due to differences in DA tone between subjects, and (c) that MPH's effects are context dependent. Because DA enhances task specific neuronal signaling and decreases noise, we also postulate that MPH-induced increases in DA could improve attention and decrease distractibility; and that since DA modulates motivation, the increases in DA would also enhance the saliency of the task facilitating the 'interest it elicits' and thus improving performance. JF - Journal of attention disorders AU - Volkow, N D AU - Fowler, J S AU - Wang, G AU - Ding, Y AU - Gatley, S J AD - Medical Department,Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - S31 EP - S43 VL - 6 Suppl 1 SN - 1087-0547, 1087-0547 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Membrane Glycoproteins KW - Membrane Transport Modulators KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - SLC6A3 protein, human KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Stereoisomerism KW - Humans KW - Dopamine -- metabolism KW - Child KW - Brain Mapping KW - Membrane Transport Proteins -- antagonists & inhibitors KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Basal Ganglia -- diagnostic imaging KW - Basal Ganglia -- drug effects KW - Membrane Transport Proteins -- metabolism KW - Brain -- drug effects KW - Central Nervous System Stimulants -- therapeutic use KW - Methylphenidate -- pharmacokinetics KW - Methylphenidate -- therapeutic use KW - Central Nervous System Stimulants -- adverse effects KW - Brain -- diagnostic imaging KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Methylphenidate -- adverse effects KW - Tomography, Emission-Computed KW - Attention Deficit Disorder with Hyperactivity -- diagnostic imaging KW - Central Nervous System Stimulants -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72873562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+attention+disorders&rft.atitle=Mechanism+of+action+of+methylphenidate%3A+insights+from+PET+imaging+studies.&rft.au=Volkow%2C+N+D%3BFowler%2C+J+S%3BWang%2C+G%3BDing%2C+Y%3BGatley%2C+S+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2002-01-01&rft.volume=6+Suppl+1&rft.issue=&rft.spage=S31&rft.isbn=&rft.btitle=&rft.title=Journal+of+attention+disorders&rft.issn=10870547&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2003-05-22 N1 - Date created - 2003-04-10 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Sulfur polymer solidification/stabilization of elemental mercury waste. AN - 71601917; 11952179 AB - Elemental mercury, contaminated with radionuclides, presents a waste disposal problem throughout the Department of Energy complex. In this paper we describe a new process to immobilize elemental mercury wastes, including those contaminated with radionuclides, in a form that is non-dispersible, will meet EPA leaching criteria, and has low mercury vapor pressure. In this stabilization and solidification process, elemental mercury is combined with an excess of powdered sulfur polymer cement (SPC) and sulfide additives in a mixing vessel and heated to approximately 40 degrees C for several hours, until all of the mercury is converted into mercuric sulfide (HgS). Additional SPC is then added and the temperature of the mixture raised to 135 degrees C, resulting in a molten liquid which is poured into a mold where it cools and solidifies. The final treated waste was characterized by powder X-ray diffraction and found to be a mixture of the hexagonal and orthorhombic forms of mercuric sulfide. The Toxicity Characteristic Leaching Procedure was used to assess mercury releases, which for the optimized process averaged 25.8 microg/l, with some samples being well below the new EPA Universal Treatment Standard of 25 microg/l. Longer term leach tests were also conducted, indicating that the leaching process was dominated by diffusion. Values for the effective diffusion coefficient averaged 7.6x10(-18) cm2/s. Concentrations of mercury vapor from treated waste in equilibrium static headspace tests averaged 0.6 mg/m3. JF - Waste management (New York, N.Y.) AU - Fuhrmann, M AU - Melamed, D AU - Kalb, P D AU - Adams, J W AU - Milian, L W AD - Environmental Research & Technology Division, Environmental Sciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. fuhrmann@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 327 EP - 333 VL - 22 IS - 3 SN - 0956-053X, 0956-053X KW - Polymers KW - 0 KW - Sulfur Compounds KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Environmental Pollution -- prevention & control KW - Temperature KW - Diffusion KW - Sulfur Compounds -- chemistry KW - Refuse Disposal KW - Polymers -- chemistry KW - Mercury -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71601917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Waste+management+%28New+York%2C+N.Y.%29&rft.atitle=Sulfur+polymer+solidification%2Fstabilization+of+elemental+mercury+waste.&rft.au=Fuhrmann%2C+M%3BMelamed%2C+D%3BKalb%2C+P+D%3BAdams%2C+J+W%3BMilian%2C+L+W&rft.aulast=Fuhrmann&rft.aufirst=M&rft.date=2002-01-01&rft.volume=22&rft.issue=3&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Waste+management+%28New+York%2C+N.Y.%29&rft.issn=0956053X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-09-17 N1 - Date created - 2002-04-15 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - BOOK T1 - Translating natural concentrations and fluxes into safety indicators for radioactive waste repositories AN - 51648232; 2006-005846 JF - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium AU - Lemos, Francisco AU - Sullivan, Terry AU - Friese, Kurt AU - Ross, Timothy AU - Barbosa, Maria A2 - Merkel, Broder J. A2 - Planer-Friedrich, Britta A2 - Wolkersdorfer, Christian Y1 - 2002 PY - 2002 DA - 2002 PB - Springer-Verlag, Berlin SN - 3540439277 KW - concentration KW - sorption KW - chemical dispersion KW - site exploration KW - waste disposal sites KW - radioactive waste KW - ground water KW - fuzzy logic KW - case studies KW - safety KW - mathematical methods KW - waste disposal KW - pH KW - Eh KW - 30:Engineering geology KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51648232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Lemos%2C+Francisco%3BSullivan%2C+Terry%3BFriese%2C+Kurt%3BRoss%2C+Timothy%3BBarbosa%2C+Maria&rft.aulast=Lemos&rft.aufirst=Francisco&rft.date=2002-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=3540439277&rft.btitle=Translating+natural+concentrations+and+fluxes+into+safety+indicators+for+radioactive+waste+repositories&rft.title=Translating+natural+concentrations+and+fluxes+into+safety+indicators+for+radioactive+waste+repositories&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 6 N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2012-06-07 ER - TY - BOOK T1 - Microbial transformations of uranium complexed with organic and inorganic ligands AN - 51643753; 2006-005881 JF - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium AU - Francis, Arokiasamy J A2 - Merkel, Broder J. A2 - Planer-Friedrich, Britta A2 - Wolkersdorfer, Christian Y1 - 2002 PY - 2002 DA - 2002 PB - Springer-Verlag, Berlin SN - 3540439277 KW - soils KW - sorption KW - metabolism KW - oxidation KW - pollution KW - solubility KW - bioremediation KW - environmental effects KW - remediation KW - waste management KW - metals KW - bacteria KW - uranium KW - actinides KW - microorganisms KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51643753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=conference&rft.jtitle=&rft.atitle=&rft.au=Francis%2C+Arokiasamy+J&rft.aulast=Francis&rft.aufirst=Arokiasamy&rft.date=2002-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=3540439277&rft.btitle=Microbial+transformations+of+uranium+complexed+with+organic+and+inorganic+ligands&rft.title=Microbial+transformations+of+uranium+complexed+with+organic+and+inorganic+ligands&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - International conference Uranium mining and hydrogeology III and the International Mine Water Association symposium N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 12 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 ER - TY - JOUR T1 - Phytoremediation; European and American trends; successes, obstacles and needs AN - 51633102; 2006-015932 AB - Phytoremediation is an emerging technology based on the use of green plants to remove, contain, inactivate or destroy harmful environmental pollutants. Recent developments in Europe and the USA show that the approach is somewhat different on both sides of the Atlantic. In Europe, phytoremediation has more basically been research driven and, based on the outcomes, applications have been envisaged. By contrast, the approach in the USA is more application and experience driven. In spite of a growing track record of commercial success, more demonstration projects are needed to prove that phytoremediation is effective in order to rigorously measure its underlying economics, and to expand its applications. More fundamental research is also required to better understand the complex interactions between pollutants, soil, plant roots and micro-organisms at the rhizosphere level, to increase the bioavailability of pollutants, to fully exploit the metabolic diversity of plants and, thus, to successfully implement this new green technology. JF - Journal of Soils and Sediments AU - Schwitzguebel, Jean-Paul AU - van der Lelie, Daniel AU - Baker, Alan AU - Glass, David J AU - Vangronsveld, Jaco Y1 - 2002 PY - 2002 DA - 2002 SP - 91 EP - 99 PB - Ecomed Publishers, Landsberg VL - 2 IS - 2 SN - 1439-0108, 1439-0108 KW - soils KW - toxic materials KW - technology KW - isotopes KW - pollutants KW - metabolism KW - soil treatment KW - pollution KW - biosurfactants KW - bioremediation KW - remediation KW - ground water KW - radioactive isotopes KW - surfactants KW - phytoremediation KW - microorganisms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51633102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Soils+and+Sediments&rft.atitle=Phytoremediation%3B+European+and+American+trends%3B+successes%2C+obstacles+and+needs&rft.au=Schwitzguebel%2C+Jean-Paul%3Bvan+der+Lelie%2C+Daniel%3BBaker%2C+Alan%3BGlass%2C+David+J%3BVangronsveld%2C+Jaco&rft.aulast=Schwitzguebel&rft.aufirst=Jean-Paul&rft.date=2002-01-01&rft.volume=2&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Soils+and+Sediments&rft.issn=14390108&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2006-01-01 N1 - Number of references - 76 N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - bioremediation; biosurfactants; ground water; isotopes; metabolism; microorganisms; phytoremediation; pollutants; pollution; radioactive isotopes; remediation; soil treatment; soils; surfactants; technology; toxic materials ER - TY - JOUR T1 - Silica recovery; a promising option to reduce geothermal power production costs AN - 51139240; 2005-009586 AB - In the development of geothermal resources, the co-production of minerals and chemicals is a promising cost-efficient strategy that would lower geothermal power production costs. The potential for commercial geothermal silica extraction from low salinity geothermal brine is enhanced due to a small chance of incorporation of other mineral species that are present at a low concentration. Selective extractions and subsequent purification are not complicated and are attractive in terms of an economically feasible recovery process. An economic assessment based on pilot plant tests is presented. JF - Transactions - Geothermal Resources Council AU - Lin, Mow S AU - Premuzic, Eugene T AU - Zhou, Wei M AU - Dong, Bin AU - DeRocher, Ted AU - Johnson, Stuart D AU - Bloomquist, R Gordon Y1 - 2002 PY - 2002 DA - 2002 SP - 149 EP - 152 PB - GRC - Geothermal Resources Council, Davis, CA VL - 26 SN - 0193-5933, 0193-5933 KW - geothermal energy KW - physical properties KW - silica KW - brines KW - chemical properties KW - purification KW - economics KW - byproducts KW - production KW - cost KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51139240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+-+Geothermal+Resources+Council&rft.atitle=Silica+recovery%3B+a+promising+option+to+reduce+geothermal+power+production+costs&rft.au=Lin%2C+Mow+S%3BPremuzic%2C+Eugene+T%3BZhou%2C+Wei+M%3BDong%2C+Bin%3BDeRocher%2C+Ted%3BJohnson%2C+Stuart+D%3BBloomquist%2C+R+Gordon&rft.aulast=Lin&rft.aufirst=Mow&rft.date=2002-01-01&rft.volume=26&rft.issue=&rft.spage=149&rft.isbn=0934412863&rft.btitle=&rft.title=Transactions+-+Geothermal+Resources+Council&rft.issn=01935933&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geothermal Resources Council 2002 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2005-01-01 N1 - Number of references - 16 N1 - PubXState - CA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - brines; byproducts; chemical properties; cost; economics; geothermal energy; physical properties; production; purification; silica ER - TY - JOUR T1 - Biological Remediation of Explosives and Related Nitroaromatic Compounds AN - 21144150; 8803996 AB - Nitroaromatics form an important group of recalcitrant xenobiotics. Only few aromatic compounds, bearing one nitro group as a substituent of the aromatic ring, are produced as secondary metabolites by microorganisms. The majority of nitroaromatic compounds in the biosphere are industrial chemicals such as explosives, dyes, polyurethane foams, herbicides, insecticides and solvents. These compounds are generally recalcitrant to biological treatment and remain in the biosphere, where they constitute a source of pollution due to both toxic and mutagenic effects on humans, fish, algae and microorganisms. However, relatively few microorganisms have been described as being able to use nitroaromatic compounds as nitrogen and/or carbon and energy source. The best-known nitroaromatic compound is the explosive TNT (2,4,6-trinitrotoluene). This article reviews the bioremediation strategies for TNT-contaminated soil and water. It comes to the following conclusion: The optimal remediation strategy for nitroaromatic compounds depends on many site-specific factors. Composting and the use of reactor systems lend themselves to treating soils contaminated with high levels of explosives (e.g. at former ammunition production facilities, where areas with a high contamination level are common). Compared to composting systems, bioreactors have the major advantage of a short treatment time, but the disadvantage of being more labour intensive and more expensive. Studies indicate that biological treatment systems, which are based on the activity of the fungus Phanerochaete chrysosporium or on Pseudomonas sp. ST53, might be used as effective methods for the remediation of highly contaminated soil and water. Phytoremediation, although not widely used now, has the potential to become an important strategy for the remediation of soil and water contaminated with explosives. It is best suited where contaminant levels are low (e.g. at military sites where pollution is rather diffuse) and where larger contaminated surfaces or volumes have to be treated. In addition, phytoremediation can be used as a polishing method after other remediation treatments, such as composting or bioslurry, have taken place. This in-situ treatment method has the advantage of lower treatment costs, but has the disadvantage of a considerable longer treatment time. In order to improve the cost-efficiency, phytoremediation of nitroaromatics (and other organic xenobiotics) could be combined with bio-energy production. This requires, however, detailed knowledge on the fate of the contaminants in the plants as well as the development of efficient treatment methods for the contaminated biomass that minimise the spreading of the contaminants into the environment during post harvest treatment. JF - Environmental Science and Pollution Research International AU - Snellinx, Z AU - Nepovim, A AU - Taghavi, S AU - Vangronsveld, J AU - Vanek, T AU - van der Lelie, D AD - Environmental Technology, Flemish Institute for Technological Research (Vito), Boeretang 200, 2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 48 EP - 61 VL - 9 IS - 1 SN - 0944-1344, 0944-1344 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Environment Abstracts KW - Bioremediation KW - Contamination KW - Xenobiotics KW - Toxicity tests KW - Biological treatment KW - Soil KW - Insecticides KW - Phytoremediation KW - Bioreactors KW - polyurethane KW - Composting KW - phytoremediation KW - Algae KW - Soil contamination KW - Biomass KW - Dyes KW - Energy resources KW - Microorganisms KW - Explosives KW - Contaminants KW - Aromatics KW - Nitrogen KW - Phanerochaete chrysosporium KW - Spreading KW - secondary metabolites KW - Pollution effects KW - Pseudomonas KW - Biosphere KW - Recycling KW - Waste management KW - Aromatic compounds KW - 2,4,6-Trinitrotoluene KW - Carbon KW - Military KW - water pollution KW - Pollution KW - Solvents KW - Herbicides KW - Pollution research KW - Foams KW - Water pollution KW - Soil pollution KW - Energy KW - Secondary metabolites KW - Pollution control KW - ENA 03:Energy KW - A 01340:Antibiotics & Antimicrobials KW - Q5 08504:Effects on organisms KW - K 03450:Ecology KW - J 02400:Human Diseases KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21144150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Pollution+Research+International&rft.atitle=Biological+Remediation+of+Explosives+and+Related+Nitroaromatic+Compounds&rft.au=Snellinx%2C+Z%3BNepovim%2C+A%3BTaghavi%2C+S%3BVangronsveld%2C+J%3BVanek%2C+T%3Bvan+der+Lelie%2C+D&rft.aulast=Snellinx&rft.aufirst=Z&rft.date=2002-01-01&rft.volume=9&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Pollution+Research+International&rft.issn=09441344&rft_id=info:doi/10.1065%2Fespr2001.09.084.2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Bioremediation; Energy resources; Solvents; Microorganisms; Pollution effects; Toxicity tests; Water pollution; Aromatics; Pollution control; Spreading; Contamination; Biosphere; Xenobiotics; Soil; Carbon; 2,4,6-Trinitrotoluene; Insecticides; Aromatic compounds; Bioreactors; polyurethane; phytoremediation; Composting; Pollution; Algae; Pollution research; Herbicides; Foams; Biomass; Soil pollution; Dyes; Energy; Secondary metabolites; Explosives; Contaminants; Nitrogen; secondary metabolites; Soil contamination; Recycling; Waste management; Biological treatment; Phytoremediation; Military; water pollution; Phanerochaete chrysosporium; Pseudomonas DO - http://dx.doi.org/10.1065/espr2001.09.084.2 ER - TY - JOUR T1 - Biological Remediation of Explosives and Related Nitroaromatic Compounds AN - 20193064; 5493882 AB - Nitroaromatics form an important group of recalcitrant xenobiotics. Only few aromatic compounds, bearing one nitro group as a substituent of the aromatic ring, are produced as secondary metabolites by microorganisms. The majority of nitroaromatic compounds in the biosphere are industrial chemicals such as explosives, dyes, polyurethane foams, herbicides, insecticides and solvents. These compounds are generally recalcitrant to biological treatment and remain in the biosphere, where they constitute a source of pollution due to both toxic and mutagenic effects on humans, fish, algae and microorganisms. However, relatively few microorganisms have been described as being able to use nitroaromatic compounds as nitrogen and/or carbon and energy source. The best-known nitroaromatic compound is the explosive TNT (2,4,6-trinitrotoluene). This article reviews the bioremediation strategies for TNT-contaminated soil and water. It comes to the following conclusion: The optimal remediation strategy for nitroaromatic compounds depends on many site-specific factors. Composting and the use of reactor systems lend themselves to treating soils contaminated with high levels of explosives (e.g. at former ammunition production facilities, where areas with a high contamination level are common). Compared to composting systems, bioreactors have the major advantage of a short treatment time, but the disadvantage of being more labour intensive and more expensive. JF - Environmental Science and Regulation International AU - Snellinx, Z AU - Nepovim, A AU - Taghavi, S AU - Vangronsveld, J AU - Vanek, T AU - van der Lelie, D AD - Environmental Technology, Flemish Institute for Technological Research (Vito), Boeretang 200, 2400 Mol, Belgium, vdlelied@bnl.gov Y1 - 2002 PY - 2002 DA - 2002 SP - 48 EP - 61 VL - 9 IS - 1 SN - 0944-1344, 0944-1344 KW - 2,4,6-trinitrotoluene KW - Bioremediation KW - Biosphere KW - Composting KW - Explosives KW - Soil remediation KW - Water purification KW - Xenobiotics KW - nitroaromatic compounds KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Pollution Abstracts KW - Contamination KW - Soil KW - Aromatic compounds KW - 2,4,6-Trinitrotoluene KW - Carbon KW - Insecticides KW - Bioreactors KW - polyurethane KW - Pollution KW - Algae KW - Solvents KW - Herbicides KW - Foams KW - Soil pollution KW - Dyes KW - Energy KW - Microorganisms KW - Secondary metabolites KW - Aromatics KW - Nitrogen KW - P 9000:ENVIRONMENTAL ACTION KW - A 01450:Environmental Pollution & Waste Treatment KW - K 03450:Ecology KW - W 30965:Miscellaneous, Reviews KW - W4 210:Bioremediation, Bioreactors & BioCycling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+and+Regulation+International&rft.atitle=Biological+Remediation+of+Explosives+and+Related+Nitroaromatic+Compounds&rft.au=Snellinx%2C+Z%3BNepovim%2C+A%3BTaghavi%2C+S%3BVangronsveld%2C+J%3BVanek%2C+T%3Bvan+der+Lelie%2C+D&rft.aulast=Snellinx&rft.aufirst=Z&rft.date=2002-01-01&rft.volume=9&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+and+Regulation+International&rft.issn=09441344&rft_id=info:doi/http%3A%2F%2Fdx.doi.org%2F10.1065%2Fespr2001.09.084.2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-12-01 N1 - Last updated - 2015-03-24 N1 - SubjectsTermNotLitGenreText - Bioremediation; Contamination; Biosphere; Xenobiotics; Soil; Insecticides; Carbon; 2,4,6-Trinitrotoluene; Aromatic compounds; Bioreactors; polyurethane; Composting; Pollution; Algae; Solvents; Herbicides; Foams; Soil pollution; Dyes; Energy; Microorganisms; Secondary metabolites; Explosives; Aromatics; Nitrogen; Soil remediation; Water purification DO - http://dx.doi.org/10.1065/espr2001.09.084.2 ER - TY - JOUR T1 - Non-framework cation migration and irreversible pressure-induced hydration in a zeolite AN - 1844921930; 2016-099816 AB - A synthetic zeolite analogue, K gallosilicate natrolite, shows irreversible P-induced (at < 1.29 GPa) hydration with retention of a high-P phase at ambient conditions. The structure of this high-P recovered phase is reported, and contrasted with the high-P phase of natrolite. The irreversible hydration behaviour is found to be associated with a rearrangement of the non-framework metal ions, which thus have an important role in mediating the overall properties of zeolites. JF - Nature (London) AU - Lee, Yongjae AU - Vogt, Thomas AU - Hriljac, Joseph A AU - Parisc, John B AU - Hanson, Jonathan C AU - Kim, Sun Jin Y1 - 2002 PY - 2002 DA - 2002 SP - 485 EP - 489 PB - Macmillan Journals, London VL - 420 IS - 6915 SN - 0028-0836, 0028-0836 KW - silicates KW - pressure KW - oxygen KW - three-dimensional models KW - tetrahedra KW - effects KW - crystal structure KW - high pressure KW - natrolite KW - hydration KW - polyhedra KW - aluminosilicates KW - zeolite group KW - cations KW - framework silicates KW - crystal chemistry KW - hydrostatic pressure KW - 01B:Mineralogy of silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844921930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+%28London%29&rft.atitle=Non-framework+cation+migration+and+irreversible+pressure-induced+hydration+in+a+zeolite&rft.au=Lee%2C+Yongjae%3BVogt%2C+Thomas%3BHriljac%2C+Joseph+A%3BParisc%2C+John+B%3BHanson%2C+Jonathan+C%3BKim%2C+Sun+Jin&rft.aulast=Lee&rft.aufirst=Yongjae&rft.date=2002-01-01&rft.volume=420&rft.issue=6915&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Nature+%28London%29&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature01265 L2 - http://www.nature.com/nature/index.html LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from Mineralogical Abstracts, United Kingdom, Twickenham, United Kingdom N1 - Date revised - 2016-01-01 N1 - SuppNotes - Based on Publisher-supplied data N1 - Last updated - 2016-12-01 N1 - CODEN - NATUAS N1 - SubjectsTermNotLitGenreText - aluminosilicates; cations; crystal chemistry; crystal structure; effects; framework silicates; high pressure; hydration; hydrostatic pressure; natrolite; oxygen; polyhedra; pressure; silicates; tetrahedra; three-dimensional models; zeolite group DO - http://dx.doi.org/10.1038/nature01265 ER - TY - JOUR T1 - Arsenic oxidation state heterogeneity and correlations with mineralogy in mine waste solids from Yellowknife AN - 1039339282; 2012-080511 JF - Program with Abstracts - Geological Association of Canada; Mineralogical Association of Canada: Joint Annual Meeting AU - Walker, S R AU - Jamieson, H E AU - Hall, G E M AU - Sutton, S R AU - Lanzirotti, A AU - Anonymous Y1 - 2002 PY - 2002 DA - 2002 SP - 121 PB - Geological Association of Canada, Waterloo, ON VL - 27 SN - 0701-8738, 0701-8738 KW - Giant Mine KW - mines KW - mine waste KW - waste rock KW - oxidation KW - arsenic KW - X-ray spectra KW - Northwest Territories KW - XANES spectra KW - synchrotron radiation KW - flotation KW - Canada KW - Yellowknife Northwest Territories KW - metals KW - Con Mine KW - Western Canada KW - spectra KW - tailings KW - sulfides KW - 02C:Geochemistry of rocks, soils, and sediments KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1039339282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.atitle=Arsenic+oxidation+state+heterogeneity+and+correlations+with+mineralogy+in+mine+waste+solids+from+Yellowknife&rft.au=Walker%2C+S+R%3BJamieson%2C+H+E%3BHall%2C+G+E+M%3BSutton%2C+S+R%3BLanzirotti%2C+A%3BAnonymous&rft.aulast=Walker&rft.aufirst=S&rft.date=2002-01-01&rft.volume=27&rft.issue=&rft.spage=121&rft.isbn=0919216811&rft.btitle=&rft.title=Program+with+Abstracts+-+Geological+Association+of+Canada%3B+Mineralogical+Association+of+Canada%3A+Joint+Annual+Meeting&rft.issn=07018738&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - MAC-GAC joint annual meeting, Saskatoon 2000; from plains to shield; the making of a continent's interior N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2012-01-01 N1 - PubXState - ON N1 - Last updated - 2012-09-14 N1 - CODEN - PAACD6 N1 - SubjectsTermNotLitGenreText - arsenic; Canada; Con Mine; flotation; Giant Mine; metals; mine waste; mines; Northwest Territories; oxidation; spectra; sulfides; synchrotron radiation; tailings; waste rock; Western Canada; X-ray spectra; XANES spectra; Yellowknife Northwest Territories ER - TY - JOUR T1 - Roles of two conserved cysteine residues in the activation of human adenovirus proteinase. AN - 72308072; 11724559 AB - The roles of two conserved cysteine residues involved in the activation of the adenovirus proteinase (AVP) were investigated. AVP requires two cofactors for maximal activity, the 11-amino acid peptide pVIc (GVQSLKRRRCF) and the viral DNA. In the AVP-pVIc crystal structure, conserved Cys104 of AVP has formed a disulfide bond with conserved Cys10 of pVIc. In this work, pVIc formed a homodimer via disulfide bond formation with a second-order rate constant of 0.12 M(-1) s(-1), and half of the homodimer could covalently bind to AVP via thiol-disulfide exchange. Alternatively, monomeric pVIc could form a disulfide bond with AVP via oxidation. Regardless of the mechanism by which AVP becomes covalently bound to pVIc, the kinetic constants for substrate hydrolysis were the same. The equilibrium dissociation constant, K(d), for the reversible binding of pVIc to AVP was 4.4 microM. The K(d) for the binding of the mutant C10A-pVIc was at least 100-fold higher. Surprisingly, the K(d) for the binding of the C10A-pVIc mutant to AVP decreased at least 60-fold, to 6.93 microM, in the presence of 12mer ssDNA. Furthermore, once the mutant C10A-pVIc was bound to an AVP-DNA complex, the macroscopic kinetic constants for substrate hydrolysis were the same as those exhibited by wild-type pVIc. Although the cysteine in pVIc is important in the binding of pVIc to AVP, formation of a disulfide bond between pVIc and AVP was not required for maximal stimulation of enzyme activity by pVIc. JF - Biochemistry AU - McGrath, W J AU - Baniecki, M L AU - Peters, E AU - Green, D T AU - Mangel, W F AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. Y1 - 2001/12/04/ PY - 2001 DA - 2001 Dec 04 SP - 14468 EP - 14474 VL - 40 IS - 48 SN - 0006-2960, 0006-2960 KW - DNA, Viral KW - 0 KW - Viral Proteins KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - adenain KW - EC 3.4.22.39 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Secondary KW - Models, Molecular KW - Enzyme Activation KW - Kinetics KW - Humans KW - In Vitro Techniques KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Statistics as Topic KW - DNA, Viral -- metabolism KW - Binding Sites KW - Viral Proteins -- genetics KW - Cysteine -- chemistry KW - Cysteine Endopeptidases -- metabolism KW - Cysteine Endopeptidases -- chemistry KW - Adenoviruses, Human -- genetics KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - Cysteine Endopeptidases -- genetics KW - Adenoviruses, Human -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72308072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Roles+of+two+conserved+cysteine+residues+in+the+activation+of+human+adenovirus+proteinase.&rft.au=McGrath%2C+W+J%3BBaniecki%2C+M+L%3BPeters%2C+E%3BGreen%2C+D+T%3BMangel%2C+W+F&rft.aulast=McGrath&rft.aufirst=W&rft.date=2001-12-04&rft.volume=40&rft.issue=48&rft.spage=14468&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-08 N1 - Date created - 2001-11-28 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Topiramate selectively attenuates nicotine-induced increases in monoamine release. AN - 72358237; 11746717 JF - Synapse (New York, N.Y.) AU - Schiffer, W K AU - Gerasimov, M R AU - Marsteller, D A AU - Geiger, J AU - Barnett, C AU - Alexoff, D L AU - Dewey, S L AD - Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. wynne@bnl.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 196 EP - 198 VL - 42 IS - 3 SN - 0887-4476, 0887-4476 KW - Anticonvulsants KW - 0 KW - Biogenic Monoamines KW - Nicotinic Agonists KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Serotonin KW - 333DO1RDJY KW - Nicotine KW - 6M3C89ZY6R KW - Dopamine KW - VTD58H1Z2X KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Microdialysis KW - Animals KW - Drug Interactions KW - Norepinephrine -- metabolism KW - Brain Chemistry -- drug effects KW - Dopamine -- metabolism KW - Serotonin -- metabolism KW - Anticonvulsants -- pharmacology KW - Fructose -- analogs & derivatives KW - Nicotine -- pharmacology KW - Nicotinic Agonists -- pharmacology KW - Biogenic Monoamines -- metabolism KW - Fructose -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72358237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=Topiramate+selectively+attenuates+nicotine-induced+increases+in+monoamine+release.&rft.au=Schiffer%2C+W+K%3BGerasimov%2C+M+R%3BMarsteller%2C+D+A%3BGeiger%2C+J%3BBarnett%2C+C%3BAlexoff%2C+D+L%3BDewey%2C+S+L&rft.aulast=Schiffer&rft.aufirst=W&rft.date=2001-12-01&rft.volume=42&rft.issue=3&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-02-05 N1 - Date created - 2001-12-17 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. AN - 72314604; 11729018 AB - OBJECTIVEThe role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the orbitofrontal cortex. Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers.METHODFifteen methamphetamine abusers and 20 non-drug-abusing comparison subjects were studied with positron emission tomography (PET) and [11C]raclopride to assess the availability of dopamine D2 receptors and with [18F]fluorodeoxyglucose to assess regional brain glucose metabolism, a marker of brain function.RESULTSMethamphetamine abusers had a significantly lower level of D2 receptor availability than comparison subjects (a difference of 16% in the caudate and 10% in the putamen). D2 receptor availability was associated with metabolic rate in the orbitofrontal cortex in abusers and in comparison subjects.CONCLUSIONSLower levels of dopamine D2 receptor availability have been previously reported in cocaine abusers, alcoholics, and heroine abusers. This study extends this finding to methamphetamine abusers. The association between level of dopamine D2 receptors and metabolism in the orbitofrontal cortex in methamphetamine abusers, which replicates previous findings in cocaine abusers, suggests that D2 receptor-mediated dysregulation of the orbitofrontal cortex could underlie a common mechanism for loss of control and compulsive drug intake in drug-addicted subjects. JF - The American journal of psychiatry AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Ding, Y S AU - Sedler, M AU - Logan, J AU - Franceschi, D AU - Gatley, J AU - Hitzemann, R AU - Gifford, A AU - Wong, C AU - Pappas, N AD - Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 2015 EP - 2021 VL - 158 IS - 12 SN - 0002-953X, 0002-953X KW - Receptors, Dopamine D2 KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Compulsive Behavior -- diagnostic imaging KW - Risk Factors KW - Humans KW - Adult KW - Male KW - Female KW - Compulsive Behavior -- physiopathology KW - Frontal Lobe -- physiopathology KW - Methamphetamine -- administration & dosage KW - Frontal Lobe -- drug effects KW - Methamphetamine -- adverse effects KW - Frontal Lobe -- diagnostic imaging KW - Energy Metabolism -- physiology KW - Energy Metabolism -- drug effects KW - Amphetamine-Related Disorders -- diagnostic imaging KW - Tomography, Emission-Computed KW - Receptors, Dopamine D2 -- drug effects KW - Receptors, Dopamine D2 -- physiology KW - Amphetamine-Related Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72314604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Low+level+of+brain+dopamine+D2+receptors+in+methamphetamine+abusers%3A+association+with+metabolism+in+the+orbitofrontal+cortex.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BDing%2C+Y+S%3BSedler%2C+M%3BLogan%2C+J%3BFranceschi%2C+D%3BGatley%2C+J%3BHitzemann%2C+R%3BGifford%2C+A%3BWong%2C+C%3BPappas%2C+N&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-12-01&rft.volume=158&rft.issue=12&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-02 N1 - Date created - 2001-11-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. AN - 72290737; 11717374 AB - Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [(11)C]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (<6 months) and then retested during protracted abstinence (12-17 months) showed significant increases with protracted abstinence (caudate, +19%; putamen, +16%). Although performance in some of the tests for which we observed an association with DA transporters showed some improvement, this effect was not significant. The DA transporter increases with abstinence could indicate that methamphetamine-induced DA transporter loss reflects temporary adaptive changes (i.e., downregulation), that the loss reflects DA terminal damage but that terminals can recover, or that remaining viable terminals increase synaptic arborization. Because neuropsychological tests did not improve to the same extent, this suggests that the increase of the DA transporters was not sufficient for complete function recovery. These findings have treatment implications because they suggest that protracted abstinence may reverse some of methamphetamine-induced alterations in brain DA terminals. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, N D AU - Chang, L AU - Wang, G J AU - Fowler, J S AU - Franceschi, D AU - Sedler, M AU - Gatley, S J AU - Miller, E AU - Hitzemann, R AU - Ding, Y S AU - Logan, J AD - Medical and Chemistry Departments, Brookhaven National Laboratory, Upton, New York 11973, USA. volkow@bnl.gov Y1 - 2001/12/01/ PY - 2001 DA - 2001 Dec 01 SP - 9414 EP - 9418 VL - 21 IS - 23 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Membrane Glycoproteins KW - Membrane Transport Proteins KW - Nerve Tissue Proteins KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Caudate Nucleus -- metabolism KW - Humans KW - Caudate Nucleus -- drug effects KW - Cerebellum -- metabolism KW - Cerebellum -- drug effects KW - Adult KW - Putamen -- metabolism KW - Tomography, Emission-Computed KW - Neuropsychological Tests KW - Time Factors KW - Female KW - Male KW - Putamen -- drug effects KW - Amphetamine-Related Disorders -- metabolism KW - Membrane Transport Proteins -- deficiency KW - Methamphetamine -- adverse effects KW - Amphetamine-Related Disorders -- rehabilitation KW - Membrane Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72290737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Loss+of+dopamine+transporters+in+methamphetamine+abusers+recovers+with+protracted+abstinence.&rft.au=Volkow%2C+N+D%3BChang%2C+L%3BWang%2C+G+J%3BFowler%2C+J+S%3BFranceschi%2C+D%3BSedler%2C+M%3BGatley%2C+S+J%3BMiller%2C+E%3BHitzemann%2C+R%3BDing%2C+Y+S%3BLogan%2C+J&rft.aulast=Volkow&rft.aufirst=N&rft.date=2001-12-01&rft.volume=21&rft.issue=23&rft.spage=9414&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-11 N1 - Date created - 2001-11-21 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - The WRDA program and emerging decontamination technologies for contaminated sediments AN - 50899968; 2002-065894 JF - AEHS Contaminated Soil Sediment & Water AU - Wenning, Richard J AU - Stern, Eric A AU - Jones, Keith W AU - Douglas, W Scott Y1 - 2001/12// PY - 2001 DA - December 2001 SP - 38 EP - 41 PB - Association for Environmental Health and Sciences (AEHS), Amherst, MA VL - 2001, December SN - 1533-4155, 1533-4155 KW - United States KW - regulations KW - techniques KW - remediation KW - waste management KW - decontamination KW - sediments KW - waterways KW - estuarine environment KW - discharge KW - heavy metals KW - programs KW - WRDA KW - monitoring KW - Water Resources Development Act KW - harbors KW - pollution KW - decision-making KW - dredged materials KW - organic compounds KW - New York KW - industrial waste KW - hydrocarbons KW - polycyclic aromatic hydrocarbons KW - coastal environment KW - policy KW - economics KW - New Jersey KW - waste disposal KW - pesticides KW - aromatic hydrocarbons KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50899968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AEHS+Contaminated+Soil+Sediment+%26+Water&rft.atitle=The+WRDA+program+and+emerging+decontamination+technologies+for+contaminated+sediments&rft.au=Wenning%2C+Richard+J%3BStern%2C+Eric+A%3BJones%2C+Keith+W%3BDouglas%2C+W+Scott&rft.aulast=Wenning&rft.aufirst=Richard&rft.date=2001-12-01&rft.volume=2001%2C+December&rft.issue=&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=AEHS+Contaminated+Soil+Sediment+%26+Water&rft.issn=15334155&rft_id=info:doi/ L2 - http://www.aehsmag.com/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - PubXState - MA N1 - Document feature - illus. N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - aromatic hydrocarbons; coastal environment; decision-making; decontamination; discharge; dredged materials; economics; estuarine environment; harbors; heavy metals; hydrocarbons; industrial waste; monitoring; New Jersey; New York; organic compounds; pesticides; policy; pollution; polycyclic aromatic hydrocarbons; programs; regulations; remediation; sediments; techniques; United States; waste disposal; waste management; Water Resources Development Act; waterways; WRDA ER - TY - JOUR T1 - The structure and biochemistry of NADH-dependent cytochrome b5 reductase are now consistent. AN - 72256966; 11695905 AB - Cytochrome b5 reductase (cb5r) (EC 1.6.6.2) catalyzes the reduction of two molecules of cytochrome b5 using NADH as the physiological electron donor. The structure of pig cb5r at 2.4 A resolution was previously reported in the literature, but it was inconsistent with the biochemistry; for example, K83 and C245 were both implicated in the mechanism, but were not located at the active site. To address this problem, we have determined the structures of cb5r from rat at 2.0 A resolution and in a complex with NAD+ at 2.3 A resolution. We found significant differences throughout the rat structure compared to that of pig, including the locations of the lysine and cysteine residues mentioned above. To test the structural models, we made single amino acid substitutions of this lysine and showed that all substitutions produced correctly folded proteins and exhibited normal flavin behavior. However, the apparent kcat(NADH) decreased, and the apparent K(m) for NADH increased; the K(m)'s for cytochrome b5 were unchanged relative to that of the wild type. The largest effect was for the glutamate-substituted protein, which was further characterized using a charge transfer assay and found to be less efficient at NADH utilization than the wild type. These results are consistent with a role for this lysine in stabilizing the NADH-bound form of cb5r. We have concluded that the pig structure was mistraced in several regions and have reinterpreted mutants in these regions that give rise to the hereditary disease methemoglobinemia. JF - Biochemistry AU - Bewley, M C AU - Marohnic, C C AU - Barber, M J AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. bewley@bnl.gov Y1 - 2001/11/13/ PY - 2001 DA - 2001 Nov 13 SP - 13574 EP - 13582 VL - 40 IS - 45 SN - 0006-2960, 0006-2960 KW - NAD KW - 0U46U6E8UK KW - Cytochrome Reductases KW - EC 1.6.2.- KW - Cytochrome-B(5) Reductase KW - EC 1.6.2.2 KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Swine KW - Crystallization KW - Animals KW - Models, Molecular KW - Humans KW - Methemoglobinemia -- genetics KW - Amino Acid Sequence KW - Lysine -- genetics KW - Rats KW - NAD -- chemistry KW - Mutagenesis, Site-Directed KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Methemoglobinemia -- enzymology KW - Protein Conformation KW - Cytochrome Reductases -- genetics KW - Cytochrome Reductases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72256966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+structure+and+biochemistry+of+NADH-dependent+cytochrome+b5+reductase+are+now+consistent.&rft.au=Bewley%2C+M+C%3BMarohnic%2C+C+C%3BBarber%2C+M+J&rft.aulast=Bewley&rft.aufirst=M&rft.date=2001-11-13&rft.volume=40&rft.issue=45&rft.spage=13574&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-11-06 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA. AN - 72236766; 11683632 AB - The interaction of the human adenovirus proteinase (AVP) with various DNAs was characterized. AVP requires two cofactors for maximal activity, the 11-amino acid residue peptide from the C-terminus of adenovirus precursor protein pVI (pVIc) and the viral DNA. DNA binding was monitored by changes in enzyme activity or by fluorescence anisotropy. The equilibrium dissociation constants for the binding of AVP and AVP-pVIc complexes to 12-mer double-stranded (ds) DNA were 63 and 2.9 nM, respectively. DNA binding was not sequence specific; the stoichiometry of binding was proportional to the length of the DNA. Three molecules of the AVP-pVIc complex bound to 18-mer dsDNA and six molecules to 36-mer dsDNA. When AVP-pVIc complexes bound to 12-mer dsDNA, two sodium ions were displaced from the DNA. A Delta of -4.6 kcal for the nonelectrostatic free energy of binding indicated that a substantial component of the binding free energy results from nonspecific interactions between the AVP-pVIc complex and DNA. The cofactors altered the interaction of the enzyme with the fluorogenic substrate (Leu-Arg-Gly-Gly-NH)2-rhodamine. In the absence of any cofactor, the Km was 94.8 microM and the kcat was 0.002 s(-1). In the presence of adenovirus DNA, the Km decreased 10-fold and the kcat increased 11-fold. In the presence of pVIc, the Km decreased 10-fold and the kcat increased 118-fold. With both cofactors present, the kcat/Km ratio increased 34000-fold, compared to that with AVP alone. Binding to DNA was coincident with stimulation of proteinase activity by DNA. Although other proteinases have been shown to bind to DNA, stimulation of proteinase activity by DNA is unprecedented. A model is presented suggesting that AVP moves along the viral DNA looking for precursor protein cleavage sites much like RNA polymerase moves along DNA looking for a promoter. JF - Biochemistry AU - McGrath, W J AU - Baniecki, M L AU - Li, C AU - McWhirter, S M AU - Brown, M T AU - Toledo, D L AU - Mangel, W F AD - Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA. Y1 - 2001/11/06/ PY - 2001 DA - 2001 Nov 06 SP - 13237 EP - 13245 VL - 40 IS - 44 SN - 0006-2960, 0006-2960 KW - DNA Primers KW - 0 KW - DNA, Viral KW - Ligands KW - Peptide Fragments KW - Viral Proteins KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Fluorescence Polarization KW - Models, Molecular KW - Enzyme Activation KW - Kinetics KW - Humans KW - Protein Conformation KW - DNA Primers -- chemistry KW - Binding Sites KW - Viral Proteins -- genetics KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Peptide Fragments -- genetics KW - Cysteine Endopeptidases -- metabolism KW - Cysteine Endopeptidases -- chemistry KW - Adenoviruses, Human -- genetics KW - Viral Proteins -- chemistry KW - Viral Proteins -- metabolism KW - Adenoviruses, Human -- enzymology KW - DNA, Viral -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72236766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Human+adenovirus+proteinase%3A+DNA+binding+and+stimulation+of+proteinase+activity+by+DNA.&rft.au=McGrath%2C+W+J%3BBaniecki%2C+M+L%3BLi%2C+C%3BMcWhirter%2C+S+M%3BBrown%2C+M+T%3BToledo%2C+D+L%3BMangel%2C+W+F&rft.aulast=McGrath&rft.aufirst=W&rft.date=2001-11-06&rft.volume=40&rft.issue=44&rft.spage=13237&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-07 N1 - Date created - 2001-10-30 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Crystallographic evidence for doxorubicin binding to the receptor-binding site in Clostridium botulinum neurotoxin B. AN - 72233921; 11679763 AB - The neurotoxins of Clostridium botulinum and tetanus bind to gangliosides as a first step of their toxin activity. Identifying suitable receptors that compete with gangliosides could prevent toxin binding to the neuronal cells. A possible ganglioside-binding site of the botulinum neurotoxin B (BoNT/B) has already been proposed and evidence is now presented for a drug binding to botulinum neurotoxin B from structural studies. Doxorubicin, a well known DNA intercalator, binds to the neurotoxin at the receptor-binding site proposed earlier. The structure of the BoNT/B-doxorubicin complex reveals that doxorubicin has interactions with the neurotoxin similar to those of sialyllactose. The aglycone moiety of the doxorubicin stacks with tryptophan 1261 and interacts with histidine 1240 of the binding domain. Here, the possibility is presented of designing a potential antagonist for these neurotoxins from crystallographic analysis of the neurotoxin-doxorubicin complex, which will be an excellent lead compound. JF - Acta crystallographica. Section D, Biological crystallography AU - Eswaramoorthy, S AU - Kumaran, D AU - Swaminathan, S AD - Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA. Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 1743 EP - 1746 VL - 57 SN - 0907-4449, 0907-4449 KW - Bacterial Proteins KW - 0 KW - rimabotulinumtoxinB KW - 0Y70779M1F KW - Doxorubicin KW - 80168379AG KW - Botulinum Toxins KW - EC 3.4.24.69 KW - Botulinum Toxins, Type A KW - Index Medicus KW - Crystallization KW - Models, Molecular KW - Crystallography, X-Ray KW - Protein Conformation KW - Binding Sites KW - Doxorubicin -- chemistry KW - Bacterial Proteins -- chemistry KW - Botulinum Toxins -- chemistry KW - Clostridium botulinum -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/72233921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.atitle=Crystallographic+evidence+for+doxorubicin+binding+to+the+receptor-binding+site+in+Clostridium+botulinum+neurotoxin+B.&rft.au=Eswaramoorthy%2C+S%3BKumaran%2C+D%3BSwaminathan%2C+S&rft.aulast=Eswaramoorthy&rft.aufirst=S&rft.date=2001-11-01&rft.volume=57&rft.issue=&rft.spage=1743&rft.isbn=&rft.btitle=&rft.title=Acta+crystallographica.+Section+D%2C+Biological+crystallography&rft.issn=09074449&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2001-12-20 N1 - Date created - 2001-10-26 N1 - Date revised - 2017-02-17 N1 - Genetic sequence - 1I1E; PDB N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Temperature-resolved synchrotron X-ray diffraction study of ramsdellite and groutite AN - 52035256; 2003-006487 AB - Ramsdellite is one of two naturally occurring polymorphs of MnO (sub 2) , and both natural and synthetic varieties are important battery materials. Ramsdellite has the diaspore structure, consisting of double chains of Mn-O octahedra that share corners to form a framework with rectangular-shaped tunnels. Post and Ross (1989) showed that most natural ramsdellite samples contain a second isostructural phase with unit-cell parameters intermediate between those of ramsdellite and groutite (MnOOH). We have refined the structure of the intermediate phase using the Rietveld method and synchrotron X-ray diffraction data that were collected at Beamline X7B, National Synchrotron Light Source, Brookhaven National Laboratory using a Mar345 imaging plate. The refinement shows longer mean Mn-O distances (1.93 Aa) relative to ramsdellite (1.89 Aa), and Jahn-Teller type distortion of the Mn-O octahedra. Both observations indicate substitution of Mn (super 3+) for about one-third of the Mn (super 4+) , presumably with coupled replacement of O (super 2-) with OH (super -) . Infra-red spectra from several samples confirm that the amount of OH (super -) is approximately proportional to the fraction of the intermediate phase. Temperature-resolved synchrotron diffraction experiments were performed for groutite and a sample with roughly equal amounts of ramsdellite and the intermediate phase. The fraction of the intermediate phase increased from approximately 50% to approximately 60% up to about 275 degrees C, and then decreased, until by 310 degrees C all of the intermediate phase had transformed to ramsdellite. A mass spectrometer monitoring effluents from the heated sample showed a water loss concurrent with the disappearance of the intermediate phase. From 310 to 450 degrees C, the ramsdellite gradually transformed to pyrolusite, but at the maximum temperature both phases remained. The groutite transformed to hausmannite and pyrolusite between approximately 250 and 290 degrees C. Between 400 and 460 degrees C the pyrolusite and hausmannite transformed to bixbyite. JF - Abstracts with Programs - Geological Society of America AU - Post, Jeffrey E AU - Heaney, Peter J AU - Hanson, Jonathan C AU - Anonymous Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 362 EP - 363 PB - Geological Society of America (GSA), Boulder, CO VL - 33 IS - 6 SN - 0016-7592, 0016-7592 KW - ramsdellite KW - experimental studies KW - X-ray diffraction data KW - crystal structure KW - Rietveld refinement KW - temperature KW - synchrotron radiation KW - laboratory studies KW - groutite KW - phase equilibria KW - oxides KW - transformations KW - industrial minerals KW - 28A:Economic geology, geology of nonmetal deposits KW - 01C:Mineralogy of non-silicates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52035256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Temperature-resolved+synchrotron+X-ray+diffraction+study+of+ramsdellite+and+groutite&rft.au=Post%2C+Jeffrey+E%3BHeaney%2C+Peter+J%3BHanson%2C+Jonathan+C%3BAnonymous&rft.aulast=Post&rft.aufirst=Jeffrey&rft.date=2001-11-01&rft.volume=33&rft.issue=6&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2001 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2003-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - crystal structure; experimental studies; groutite; industrial minerals; laboratory studies; oxides; phase equilibria; ramsdellite; Rietveld refinement; synchrotron radiation; temperature; transformations; X-ray diffraction data ER - TY - JOUR T1 - X-ray diffraction evidence for transition metal cation exchange in anionic clays in room-temperature aqueous fluids AN - 52034596; 2003-006486 AB - In anionic clays, trivalent cations within brucite-like octahedral sheets generate a net positive charge that is electrostatically balanced by anionic groups in the interlayer region. Many anionic clays exhibit a heightened ability to swap their interlayer anions with negatively charged species in solution, such as cyanide ions, pesticides, and radioactive wastes. Based on measurements of changes in fluid chemistry, Komarneni et al. (1998) have argued that hydrotalcite-like anionic clays can remove dissolved transition metal cations (e.g., Co (super 2+) , Ni (super 2+) , Zn (super 2+) , and Cu (super 2+) ) from solutions at room temperature by diadochic exchange reactions with octahedral Mg. We have examined the reaction products of hydrotalcite-like clays in the presence of dissolved transition metals using synchrotron X-ray powder diffraction, and our Rietveld analyses provide direct support for the proposed exchange model. Commercially prepared manasseite {[Mg (sub 6) (super 2+) Al (sub 2) (super 3+) (OH) (sub 16) ] (super 2+) . [CO (sub 3) .4H (sub 2) O] (super 2-) } powders (0.05 gm) were equilibrated at room temperature in 25 ml solutions at pH 4-5 with 0.01 M of CuCl (sub 2) and, separately, ZnCl (sub 2) for 24 hr at room temperature. Synchrotron X-ray diffraction data for the dried powders were collected at Beamline X7B, National Synchrotron Light Source, Brookhaven National Laboratory using a Mar345 imaging plate. Rietveld analyses of the starting and reacted powders were well-behaved with final weighted residuals below 0.04. The Cu-exchanged manasseite experiment generated a significant amount (57 wt%) of paratacamite [Cu (sub 2) Cl(OH) (sub 3) ] as a side-product with minor quantities of periclase. Occupancy factors for the octahedral sites in the cupric manasseite refined to 31% Cu and 69% Mg. Similarly, the Zn-exchanged manasseite yielded minor amounts of brucite, periclase, and zincite; octahedral occupancy factors for manasseite refined to 21% Zn and 79% Mg. Our analyses also have offered the first high-resolution structure refinement for endmember manasseite with a = 3.0534(1) Aa; and c = 22.964(2) Aa; in space group R-3m (R (sub wp) = 0.0285). Moreover, our temperature-resolved synchrotron heating experiments revealed that Cu-substituted manasseite exhibits a thermal stability that is very similar to the end-member composition, with both structures transforming reconstructively via dehydration reactions at approximately 150 degrees C. JF - Abstracts with Programs - Geological Society of America AU - Heaney, Peter J AU - Post, Jeffrey E AU - Hanson, Jonathan C AU - Komarneni, Sridhar AU - Anonymous Y1 - 2001/11// PY - 2001 DA - November 2001 SP - 362 PB - Geological Society of America (GSA), Boulder, CO VL - 33 IS - 6 SN - 0016-7592, 0016-7592 KW - mineral interlayer KW - zinc KW - high-resolution methods KW - hydrotalcite KW - experimental studies KW - cobalt KW - X-ray diffraction data KW - copper KW - octahedra KW - clay mineralogy KW - manasseite KW - aqueous solutions KW - Rietveld refinement KW - synchrotron radiation KW - laboratory studies KW - polyhedra KW - metals KW - nickel KW - ion exchange KW - geochemistry KW - carbonates KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52034596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=X-ray+diffraction+evidence+for+transition+metal+cation+exchange+in+anionic+clays+in+room-temperature+aqueous+fluids&rft.au=Heaney%2C+Peter+J%3BPost%2C+Jeffrey+E%3BHanson%2C+Jonathan+C%3BKomarneni%2C+Sridhar%3BAnonymous&rft.aulast=Heaney&rft.aufirst=Peter&rft.date=2001-11-01&rft.volume=33&rft.issue=6&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, 2001 annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2003-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - aqueous solutions; carbonates; clay mineralogy; cobalt; copper; experimental studies; geochemistry; high-resolution methods; hydrotalcite; ion exchange; laboratory studies; manasseite; metals; mineral interlayer; nickel; octahedra; polyhedra; Rietveld refinement; synchrotron radiation; X-ray diffraction data; zinc ER - TY - JOUR T1 - Assessing Phytoremediation's Progress in the United States and Europe AN - 19424233; 5323829 AB - Phytoremediation--using plants and trees to remove or neutralize contaminants--holds great promise for unobtrusively and cost-effectively treating soils, groundwater, and wastewaters contaminated with heavy metals, organic xenobiotics, and radionuclides. Although still an emerging technology, the phytoremediation market is fast-growing, especially in the United States and Europe. Like any other new approach, phytoremediation will only be accepted if its success is demonstrated. The key factors are low cost (compared to classical remediation techniques) and aesthetic aspects, making it suitable for remediating large contaminated sites in populated areas. JF - Environmental Science & Technology AU - Van Der Lelie, D AU - Schwitzguebel, J-P AU - Glass, D J AU - Vangronsveld, J AU - Baker, A AD - Brookhaven National Laboratory, Upton, NY, USA Y1 - 2001/11/01/ PY - 2001 DA - 2001 Nov 01 SP - 446 EP - 452A VL - 35 IS - 21 SN - 0013-936X, 0013-936X KW - Europe KW - USA KW - Biotechnology and Bioengineering Abstracts; Pollution Abstracts; Water Resources Abstracts; Aqualine Abstracts KW - Bioremediation KW - Phytoremediation KW - Pollution (Soil) KW - phytoremediation KW - W 30950:Waste Treatment & Pollution Clean-up KW - P 9000:ENVIRONMENTAL ACTION KW - SW 3070:Water quality control KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19424233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science+%26+Technology&rft.atitle=Assessing+Phytoremediation%27s+Progress+in+the+United+States+and+Europe&rft.au=Van+Der+Lelie%2C+D%3BSchwitzguebel%2C+J-P%3BGlass%2C+D+J%3BVangronsveld%2C+J%3BBaker%2C+A&rft.aulast=Van+Der+Lelie&rft.aufirst=D&rft.date=2001-11-01&rft.volume=35&rft.issue=21&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Environmental+Science+%26+Technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2002-08-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - phytoremediation; Phytoremediation; Pollution (Soil); Bioremediation; Europe ER - TY - JOUR T1 - Constitutive competence for genetic transformation in Streptococcus pneumoniae caused by mutation of a transmembrane histidine kinase AN - 18132239; 5277659 AB - Competence for DNA uptake and genetic transformation in Streptococcus pneumoniae is regulated by a quorum-sensing system. A competence-stimulating polypeptide (CSP) is secreted by the bacteria and acts back on the cells via a transmembrane histidine kinase. This enzyme phosphorylates a response regulator that activates synthesis of a SigH-like protein. The new sigma factor enables expression of a set of proteins transcribed from a novel promoter. A mutation called trt had been found that circumvented this regulation. The mutant cells are constitutively competent; that is, they can be transformed at low cell densities, in the presence of proteases that attack CSP, or during growth at low pH. In this work, cells containing trt were shown to be competent even in the presence of a comAB mutation that blocks secretion of CSP. The trt mutation was localized to comD, the gene encoding the transmembrane histidine kinase. A DNA segment of the trt mutant corresponding to comCDE was cloned, and it was shown to contain the trt mutation by its ability to confer constitutive competence. A two-step assay, which was based on transfer of trt to a wild strain and screening for transformability in the presence of trypsin, served to locate the trt mutation precisely. It corresponds to a GC arrow right AT transition, which changes Asp in the histidine kinase to Asn. This alteration in the carboxyl terminal half of the protein, which is cytoplasmically located and contains the phosphorylase activity, presumably alters the enzyme conformation so that it is permanently activated, independent of signals from the transmembrane domain. These results may help illuminate the mechanism by which external signals affect kinase action in two-component regulatory systems, and they may be of practical value in facilitating genetic studies by rendering pneumococcal strains permanently competent. JF - Molecular Microbiology AU - Lacks, SA AU - Greenberg, B AD - Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA., lacks@bnl.gov Y1 - 2001/11// PY - 2001 DA - Nov 2001 SP - 1035 EP - 1045 PB - Blackwell Science Ltd VL - 42 IS - 4 SN - 0950-382X, 0950-382X KW - cDNA KW - amino acid sequence prediction KW - SigH protein KW - comA gene KW - comB gene KW - competence-stimulating polypeptide KW - trt gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Transformation KW - Histidine kinase KW - Streptococcus pneumoniae KW - Nucleotide sequence KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/18132239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Constitutive+competence+for+genetic+transformation+in+Streptococcus+pneumoniae+caused+by+mutation+of+a+transmembrane+histidine+kinase&rft.au=Lacks%2C+SA%3BGreenberg%2C+B&rft.aulast=Lacks&rft.aufirst=SA&rft.date=2001-11-01&rft.volume=42&rft.issue=4&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1046%2Fj.1365-2958.2001.02697.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Streptococcus pneumoniae; Histidine kinase; Transformation; Nucleotide sequence DO - http://dx.doi.org/10.1046/j.1365-2958.2001.02697.x ER - TY - JOUR T1 - Chemistry of NO2 on oxide surfaces: formation of NO3 on TiO2(110) and NO2O vacancy interactions. AN - 71200544; 11572680 AB - Synchrotron-based high-resolution photoemission, X-ray absorption near-edge spectroscopy, and first-principles density functional (DF) slab calculations were used to study the interaction of NO(2) with a TiO(2)(110) single crystal and powders of titania. The main product of the adsorption of NO(2) on TiO(2)(110) is surface nitrate with a small amount of chemisorbed NO(2). A similar result is obtained after the reaction of NO(2) with polycrystalline powders of TiO(2) or other oxide powders. This trend, however, does not imply that the metal centers of the oxides are unreactive toward NO(2). An unexpected mechanism is seen for the formation of NO(3). Photoemission data and DF calculations indicate that the surface nitrate forms through the disproportionation of NO(2) on Ti sites (2NO(2,ads) --> NO(3,ads) + NO(gas)) rather than direct adsorption of NO(2) on O centers of titania. Complex interactions take place between NO(2) and O vacancies of TiO(2)(110). Electronic states associated with O vacancies play a predominant role in the bonding and surface chemistry of NO(2). The adsorbed NO(2), on its part, affects the thermochemical stability of O vacancies, facilitating their migration from the bulk to the surface of titania. The behavior of the NO(2)/titania system illustrates the importance of surface and subsurface defects when using an oxide for trapping or destroying NO(x)() species in the prevention of environmental pollution (DeNOx operations). JF - Journal of the American Chemical Society AU - Rodriguez, J A AU - Jirsak, T AU - Liu, G AU - Hrbek, J AU - Dvorak, J AU - Maiti, A AD - Department of Chemistry, Brookhaven National Laboratory, Upton, New York 11953, USA. rodrigez@bnl.gov Y1 - 2001/10/03/ PY - 2001 DA - 2001 Oct 03 SP - 9597 EP - 9605 VL - 123 IS - 39 SN - 0002-7863, 0002-7863 KW - Environmental Pollutants KW - 0 KW - Nitrogen Oxides KW - Oxides KW - titanium dioxide KW - 15FIX9V2JP KW - nitrogen trioxide KW - 16E0524PXI KW - Titanium KW - D1JT611TNE KW - Nitrogen Dioxide KW - S7G510RUBH KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Environmental Pollutants -- chemical synthesis KW - Surface Properties KW - Titanium -- chemistry KW - Nitrogen Dioxide -- chemistry KW - Nitrogen Oxides -- chemistry KW - Oxygen -- chemistry KW - Oxides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/71200544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Chemistry+of+NO2+on+oxide+surfaces%3A+formation+of+NO3+on+TiO2%28110%29+and+NO2%26lt%3B--%26gt%3BO+vacancy+interactions.&rft.au=Rodriguez%2C+J+A%3BJirsak%2C+T%3BLiu%2C+G%3BHrbek%2C+J%3BDvorak%2C+J%3BMaiti%2C+A&rft.aulast=Rodriguez&rft.aufirst=J&rft.date=2001-10-03&rft.volume=123&rft.issue=39&rft.spage=9597&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2002-01-02 N1 - Date created - 2001-09-26 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-22 ER - TY - JOUR T1 - Cerebral glucose transport implies individualized glial cell function. AN - 85274573; pmid-11598493 AB - Previous positron emission tomography (PET) measurements of cerebral glucose transport using [11C]-3-O-methylglucose (CMG) suggested an interindividual variation in the values of the rate constant of tracer outflow (k2) larger than that for the clearance rate of inflow (K1). These two parameters were examined in healthy cerebral cortex by dynamic PET in 4 men and 2 women (aged 24 to 73 years) without neurologic disease, and in 1 man (42 years) with a recent left hemispheric cerebral infarction under normoglycemia (average blood plasma d-glucose concentration, 5.44 +/- 1.94 micromol/mL) and again under hyperglycemia (average, 10.24 +/- 1.44 micromol/mL). Time-radioactivity curves were obtained from healthy cortex (grey matter) and plasma and analyzed for the values of K1 and k2 by two graphical approaches and two fitting procedures. Both K1 and k2 significantly declined with increasing plasma glucose levels. A highly significant interindividual but not intraindividual variability for k2 was found at normoglycemia and hyperglycemia. The interindividual variability of K1, although borderline significant, was less than that of k2. Accordingly variable were the distribution volumes K1/k2. These data suggest individualized glial cell function and may be relevant to pathogenesis of neuropsychiatric disease. JF - Journal of Cerebral Blood Flow and Metabolism AU - Feinendegen, L E AU - Herzog, H AU - Thompson, K H AD - Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA. PY - 2001 SP - 1160 EP - 1170 VL - 21 IS - 10 SN - 0271-678X, 0271-678X KW - Reference Values KW - Cerebral Infarction KW - Human KW - Glucose KW - Aged KW - Fasting KW - Brain Diseases KW - Infection KW - Blood Glucose KW - Neuroglia KW - Lung Neoplasms KW - Kinetics KW - Glucose Clamp Technique KW - Adult KW - Middle Age KW - Tomography, Emission-Computed KW - 3-O-Methylglucose KW - Female KW - Male KW - Blood-Brain Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85274573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.atitle=Cerebral+glucose+transport+implies+individualized+glial+cell+function.&rft.au=Feinendegen%2C+L+E%3BHerzog%2C+H%3BThompson%2C+K+H&rft.aulast=Feinendegen&rft.aufirst=L&rft.date=2001-10-01&rft.volume=21&rft.issue=10&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cerebral+Blood+Flow+and+Metabolism&rft.issn=0271678X&rft_id=info:doi/ LA - eng DB - ComDisDome N1 - Last updated - 2010-05-07 ER - TY - JOUR T1 - Synchrotron X-ray fluorescence and secondary ion mass spectrometry in tree ring microanalysis; applications to dendroanalysis AN - 52153360; 2002-005214 JF - X-Ray Spectrometry AU - Martin, R R AU - Sham, T K AU - Won, G Wong AU - Jones, K W AU - Feng, H Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 338 EP - 341 PB - Wiley, Chichester VL - 30 IS - 5 SN - 0049-8246, 0049-8246 KW - methods KW - mining KW - Spermatophyta KW - ion probe data KW - lakes KW - mass spectra KW - Coniferales KW - atmospheric precipitation KW - environmental analysis KW - Pinus KW - apparatus KW - Sudbury Ontario KW - spectra KW - rain KW - pH KW - heavy metals KW - water KW - soils KW - Plantae KW - Gymnospermae KW - pollution KW - Pinus resinosa KW - Ontario KW - acid rain KW - Canada KW - tree rings KW - Daisy Lake KW - Pinaceae KW - trees KW - seasonal variations KW - Eastern Canada KW - instruments KW - 22:Environmental geology KW - 02A:General geochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/52153360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=X-Ray+Spectrometry&rft.atitle=Synchrotron+X-ray+fluorescence+and+secondary+ion+mass+spectrometry+in+tree+ring+microanalysis%3B+applications+to+dendroanalysis&rft.au=Martin%2C+R+R%3BSham%2C+T+K%3BWon%2C+G+Wong%3BJones%2C+K+W%3BFeng%2C+H&rft.aulast=Martin&rft.aufirst=R&rft.date=2001-10-01&rft.volume=30&rft.issue=5&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=X-Ray+Spectrometry&rft.issn=00498246&rft_id=info:doi/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 13 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - XRSPAX N1 - SubjectsTermNotLitGenreText - acid rain; apparatus; atmospheric precipitation; Canada; Coniferales; Daisy Lake; Eastern Canada; environmental analysis; Gymnospermae; heavy metals; instruments; ion probe data; lakes; mass spectra; methods; mining; Ontario; pH; Pinaceae; Pinus; Pinus resinosa; Plantae; pollution; rain; seasonal variations; soils; spectra; Spermatophyta; Sudbury Ontario; tree rings; trees; water ER - TY - JOUR T1 - Birnessite catalysis of the Maillard reaction; its significance in natural humification AN - 50152116; 2002-045461 AB - Although mineral colloids are known to play a significant role in transforming organic matter in soils and sediments, there still are many gaps in our understanding of the mechanisms of organic-mineral interactions. In this study, we investigated the role of a major oxide-mineral birnessite (a form of Mn(IV) oxide) in catalyzing the condensation reaction between sugars and amino acids, the Maillard reaction, for forming humic substances. The Maillard reaction is perceived to be a major pathway in natural humification. Using a suite of spectroscopic methods (including ESR, XANES, EXAFS and (super 13) C NMR), our results show that Mn(IV) oxide markedly accelerates the Maillard reaction between glucose and glycine at ranges of temperatures and pH typical of natural environments. These results demonstrate the importance of manganese oxide catalysis in the Maillard reaction, and its significance in the natural abiotic formation of humic substances. JF - Geophysical Research Letters AU - Jokic, A AU - Frenkel, A I AU - Vairavamurthy, M A AU - Huang, P M Y1 - 2001/10// PY - 2001 DA - October 2001 SP - 3899 EP - 3902 PB - American Geophysical Union, Washington, DC VL - 28 IS - 20 SN - 0094-8276, 0094-8276 KW - soils KW - Maillard reaction KW - glycine KW - mechanism KW - humification KW - organic compounds KW - organic acids KW - chemical reactions KW - birnessite KW - amino acids KW - glucose KW - sediments KW - oxides KW - spectra KW - pH KW - 25:Soils UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50152116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Geophysical+Research+Letters&rft.atitle=Birnessite+catalysis+of+the+Maillard+reaction%3B+its+significance+in+natural+humification&rft.au=Jokic%2C+A%3BFrenkel%2C+A+I%3BVairavamurthy%2C+M+A%3BHuang%2C+P+M&rft.aulast=Jokic&rft.aufirst=A&rft.date=2001-10-01&rft.volume=28&rft.issue=20&rft.spage=3899&rft.isbn=&rft.btitle=&rft.title=Geophysical+Research+Letters&rft.issn=00948276&rft_id=info:doi/10.1029%2F2001GL013839 L2 - http://www.agu.org/journals/gl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2002-01-01 N1 - Number of references - 25 N1 - PubXState - DC N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - CODEN - GPRLAJ N1 - SubjectsTermNotLitGenreText - amino acids; birnessite; chemical reactions; glucose; glycine; humification; Maillard reaction; mechanism; organic acids; organic compounds; oxides; pH; sediments; soils; spectra DO - http://dx.doi.org/10.1029/2001GL013839 ER - TY - JOUR T1 - Cloning and Functional Analysis of the pbr Lead Resistance Determinant of Ralstonia metallidurans CH34 AN - 17907905; 5181570 AB - The lead resistance operon, pbr, of Ralstonia metallidurans (formerly Alcaligenes eutrophus) strain CH34 is unique, as it combines functions involved in uptake, efflux, and accumulation of Pb(II). The pbr lead resistance locus contains the following structural resistance genes: (i) pbrT, which encodes a Pb(II) uptake protein; (ii) pbrA, which encodes a P-type Pb(II) efflux ATPase; (iii) pbrB, which encodes a predicted integral membrane protein of unknown function; and (iv) pbrC, which encodes a predicted prolipoprotein signal peptidase. Downstream of pbrC, the pbrD gene, encoding a Pb(II)-binding protein, was identified in a region of DNA, which was essential for functional lead sequestration. Pb(II)-dependent inducible transcription of pbrABCD from the PpbrA promoter is regulated by PbrR, which belongs to the MerR family of metal ion-sensing regulatory proteins. This is the first report of a mechanism for specific lead resistance in any bacterial genus. JF - Journal of Bacteriology AU - Borremans, B AU - Hobman, J L AU - Provoost, A AU - Brown, N L AU - van der Lelie, D AD - Brookhaven National Laboratory (BNL), Biology Department, Upton, NY 11973-5000., vdlelied@bnl.gov Y1 - 2001/10// PY - 2001 DA - Oct 2001 SP - 5651 EP - 5658 VL - 183 IS - 19 SN - 0021-9193, 0021-9193 KW - cDNA KW - amino acid sequence prediction KW - MeerR protein KW - pbrA gene KW - pbrB gene KW - pbrC gene KW - pbrD gene KW - pbrT gene KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Adenosinetriphosphatase KW - Nucleotide sequence KW - Ralstonia metallidurans KW - Lead KW - G 07320:Bacterial genetics KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17907905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Cloning+and+Functional+Analysis+of+the+pbr+Lead+Resistance+Determinant+of+Ralstonia+metallidurans+CH34&rft.au=Borremans%2C+B%3BHobman%2C+J+L%3BProvoost%2C+A%3BBrown%2C+N+L%3Bvan+der+Lelie%2C+D&rft.aulast=Borremans&rft.aufirst=B&rft.date=2001-10-01&rft.volume=183&rft.issue=19&rft.spage=5651&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.183.19.5651-5658.2001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ralstonia metallidurans; Lead; Adenosinetriphosphatase; Nucleotide sequence DO - http://dx.doi.org/10.1128/JB.183.19.5651-5658.2001 ER - TY - JOUR T1 - Intercomparison of results for a PWR rod ejection accident AN - 18128389; 5224081 AB - This study is part of an overall program to understand the uncertainty in best-estimate calculations of the local fuel enthalpy during the rod ejection accident. Local fuel enthalpy is used as the acceptance criterion for this design-basis event and can also be used to estimate fue